Kornimate/medical-research-clean huggingface dataset:
modulation of csf amyloid-beta concentrations via behavioral sleep deprivation and pharmacological sleep induction

Conditions: Amyloid-beta

Summary: the purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (csf) through modulation of the sleep-wake cycle.

the purpose of this research study is to investigate whether or not increasing or decreasing duration of sleep over one night will change the concentration of amyloid-beta in cerebral spinal fluid (csf).

Eligibility criteria:
inclusion criteria: * cognitively normal or cdr 0 * negative for amyloid deposition by pet pittsburgh compound-b (pib) imaging or csf amyloid-beta-42 concentration * age 18-60 * average reported sleep time 6-10hrs exclusion criteria: * diagnosis of a sleep disorder such as sleep apnea, narcolepsy, or restless leg syndrome * positive ambulatory sleep study for obstructive sleep apnea (ahi \> 5 respiratory events per hour) that will be performed as part of initial screening prior to enrollment * clinical dementia rating (cdr) \> 0 * tremor or other neurologic injury in the non-dominant upper extremity (such as stroke or tremor) that would prevent the use of actigraphy * current sleep walking or other sleep parasomnia * diagnosis and treatment of stroke, myocardial infarction or heart attack, * coronary artery disease, atrial fibrillation, or congestive heart failure * diagnosis and treatment of asthma or chronic obstructive pulmonary disease (copd) * diagnosis and treatment of bipolar disorder, major depression, or schizophrenia * current urinary or fecal incontinence * currently on a low salt diet * diagnosis and treatment of a neurologic disorder such as parkinson's disease, epilepsy, multiple sclerosis * currently taking any blood thinner medications such as warfarin, plavix, or aspirin * kidney disease resulting in renal impairment * liver disease resulting in hepatic dysfunction * pregnancy * currently taking sedating medications such as benzodiazepines * alcohol use at bedtime * tobacco use * bmi \>40 * contraindication to lumbar puncture * diabetes * sleep schedule outside the range of bedtime: 8pm-12am and waketime 4am-8am * self reported difficulty sleeping in an unfamiliar environment * use of sedative-hypnotic medications * inability to get in and out of bed * history or presence of any clinically significant medical condition, behavioral or psychiatric disorder, or surgical history based on medical record or patient report * history of drug abuse within the past 6 months * positive score on 2 or more categories on the berlin questionnaire * participation in another investigational medicinal product or investigational device within the last 30 days
musculoskeletal ultrasound for diagnosis of shoulder dislocation reduction

Conditions: Ultrasound; Shoulder Dislocation; Musculoskeletal Injury

Summary: this study will compare the current standard of care post reduction plain film x ray for confirmation of shoulder reduction to point of care ultrasound. patients will receive both the current standard of care post reduction x ray and point of care ultrasound to act as their own comparators


Eligibility criteria:
inclusion criteria: * adults greater than or equal to 18 years * acute shoulder dislocation exclusion criteria: * associated fracture * associated neurovascular injury
tobramycin exposure from active calcium sulfate bone graft substitute

Conditions: Orthopedic Operations

Summary: this study aimed to assess the systemic absorption and disposition of tobramycin in patients treated with a tobramycin-laden bone graft substitute (osteoset® t).


Eligibility criteria:
inclusion criteria: * adult (\> or =18 years old) patients * treatment with osteoset® t exclusion criteria: * intravenous tobramycin

Keywords: tobramycin bone graft substitute pharmacokinetics renal failure
using baby books to promote maternal and child health

Conditions: Condition 1 - Educational Condition (Educational Book Group); Condition 2 - Non-educational Condition (Non-educational Book Group); Condition 3 - Control Condition (No-book Group)

Summary: the baby books project tests whether embedding educational information into baby books can improve the health and wellbeing of first-time mothers and their young children.

this study tests the efficacy of embedding educational information (i.e., pediatric anticipatory guidance) into baby books that first-time mothers read to their infants. this 3-group longitudinal study recruited first-time mothers in their third trimester of pregnancy, randomly assigned them to conditions, and followed them until the child was 18 months of age. one group received educational baby books, another group was given the same illustrated books with non-educational text, and the third group was not given any books. thus, the effects of educational reading could be parsed from the effects of reading alone. the study aimed to test whether embedding pediatric anticipatory guidance in picture books is an effective method for increasing maternal knowledge of child development, parenting strategies, and safety practices, improving parenting beliefs and attitudes (e.g., parenting efficacy, importance of reading, use of corporal punishment), supporting optimal parenting practices (e.g., breastfeeding and nutrition, responsiveness, safety practices), improving maternal health (stress, depression), and supporting children's healthier development (injuries, illness, immunizations, and linguistic, social, and cognitive development). survey and observational data collection occurred in participants' homes during their third trimester of pregnancy and when their child was 2, 4, 6, 9, 12, and 18 months of age. twelve phone call interviews were conducted between these home visits. when children were 18 months, a retrospective medical chart audit was conducted.

Eligibility criteria:
inclusion criteria: * women who are pregnant with first child and able to read in english at a first grade reading level exclusion criteria: * women with other children, men, those not able to read in english at a first grade level

Keywords: anticipatory guidance baby books safety
efficacy and safety study of mk0359 in patients with arthritis (0359-017)

Conditions: Rheumatoid Arthritis

Summary: efficacy and safety study of mk0359 in patients with arthritis


Eligibility criteria:
inclusion criteria: * you are 18-65 years of age and have rheumatoid arthritis * you must be able to read and understand patient questionnaires exclusion criteria: * you have had certain types of surgery, certain types of cancer or history of tuberculosis (tb) or hiv.
a stitch in time may save lives: turning poor bednets into good ones

Conditions: Malaria

Summary: although the use of mosquito nets has increased in africa, many of the nets used are in a poor state, and not an effective barrier against mosquitoes. this pilot study examines whether subsistence farmers in rural africa can be encouraged to repair their mosquito nets and use their bednets appropriately. attitudes and practises on sewing and net use were examined in the gambia and an intervention developed to promote net repair. songs and posters were used to emphasise the importance of repairing nets and their correct use, and served as aural and visual reminders to repair nets now rather than postpone this household chore. the intervention was aimed at effectively and cheaply turning a poor net into a good one.

sleeping under an insecticide-treated net protects the sleeper from mosquito bites and is highly effective means of reducing the risk of malaria. recent studies in the gambia and kenya have shown that untreated bednets in good condition can also protect against malaria (51% protection against parasitaemia, 95% cis 34-64%). however, most children in rural gambia sleep under untreated nets in poor condition, often with a few holes, and do not close their nets properly at night. these children remain exposed to mosquito bites and the risk of malaria. this pilot study examines whether subsistence farmers in rural africa can be encouraged to repair their mosquito nets and use their bednets appropriately. attitudes and practises on sewing and net use were examined in rural gambia and an intervention developed to promote net repair. songs and posters were used to emphasise the importance of repairing nets and their correct use, and served as aural and visual reminders to repair nets now rather than postpone this household chore. the intervention was aimed at effectively and cheaply turning a poor net into a good one. the intervention was developed and implemented in two neighbouring villages in the gambia, with each village composing their own songs. there was no formal control village. an internal comparison group was used in which the nets of responders and non-responders living within the same village were compared.the success of the intervention was assessed by: recording the number of nets repaired and used correctly for malarial prevention before and after the intervention; by counts of mosquitoes entering the nets classified according to number of holes and degree of repair; as well as by canvassing participants' opinions.

Eligibility criteria:
inclusion criteria: * community consent * willingness to participate in study exclusion criteria: * none

Keywords: mosquito nets malaria prevention songs posters net repair bednets
influence of acetylsalicylic acid and low molecular weight heparins on the incidence of renal hematoma of shockwave lithotripsy

Conditions: Urolithiasis; Renal Hematoma

Summary: retrospective analysis of patients that received shockwave lithotripsy as treatment of ureteral or kidney stones. condition examinated is the effect of low molecular weight heparins and acetylsalicylic acid on the formation of renal hematoma after shockwave lithotripsy. primary outcome is documented hematoma in a postoperative ultrasound control. secondary outcomes are perioperative complication, need for erythrocyte tranfusion, interventions for bleeding control, readmission or death within 30 days.


Eligibility criteria:
inclusion criteria: * consent * stones in kidney and proximal ureter * treatment with shockwave lithotripsy for urolithiasis between january 2009 and september 2015 at kantonsspital winterthur exclusion criteria: * other position of ureteral stones * missing data in patient reports * refused consent * under age limit
methoxyflurane or virtual reality headset vs standard analgesic management for the reduction of anterior shoulder dislocation (hypnolux)

Conditions: Anterior Shoulder Dislocation

Summary: anterior shoulder dislocation is a pathology frequently encountered in emergency medicine. the success in reducing anterior shoulder dislocations depends on muscle relaxation, which is itself conditioned by the patient's pain and apprehension. however, there is no consensus on the optimal technique for reducing anterior shoulder dislocation or the analgesia associated with it. analgesia with methoxyflurane showed a greater reduction in post-traumatic pain compared to standard analgesic treatment and faster action of methoxyflurane. a retrospective study which has compared analgesia with methoxyflurane and analgesic sedation with propofol found a shoulder reduction success rate of 80% and a reduction in the average length of stay in the emergency department. finally, the use of virtual reality in pain management is emerging in our practices by allowing pre- and per-procedure hypno-sedation-analgesia. however, the use of virtual reality headsets has not been studied in the management of anterior shoulder dislocation. the use of these two techniques could therefore limit the use of procedural sedation in the context of shoulder dislocation reduction.


Eligibility criteria:
inclusion criteria: * pregnant and/or breastfeeding women and women of childbearing age who do not have effective contraception (hormonal, mechanical or surgical). * patients with difficulties in understanding or using the devices studied. * patients with a contraindication to the use of one of the studied devices. * patients with a history of relevant shoulder surgery * presence of other associated trauma, * previous inclusion in the same study exclusion criteria: * withdrawal of voluntary informed consent from the patient * violation of protocol * presence of a fracture associated with the dislocation (excluding malgaigne's notches) * posterior, inferior or erecta dislocation * presence of initial vascular and nerve complications * any indication for surgical management
lung protection strategy in open heart surgery: which tidal volume is better 8ml/kg or 6ml/kg

Conditions: Lung Injury, Acute; Ventilator-Induced Lung Injury; Ventilator Adverse Event

Summary: respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. there were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. these complications increase cost by prolonging morbidity and morbidity as well as hospital stay. intraoperative and postoperative mechanical ventilation strategies can prevent these complications. cpb stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. although coronary artery bypass graft surgery (cabg) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ards), mortality is quite high. lung-protective ventilation strategies commonly used for prevention of ards. ferrando et al. have proposed pulmonary ventilation with a tidal volume (tv) of less than 10 ml / kg as a pulmonary intraoperative protective ventilation strategy. investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg tv, which were recommended as lung protective ventilation strategies during anesthesia.


Eligibility criteria:
inclusion criteria: * undergoing cardiopulmonary bypass exclusion criteria: * severe copd * chronic anemia * active smoker * chronic kidney disease
anesthetic complication among acute ischemic stroke patients during endovascularization therapy

Conditions: Anesthetic Complication

Summary: retrospective descriptive study

retrospective chart review from january 2014 to december 2015

Eligibility criteria:
inclusion criteria: - acute ischemic stroke patients who received endovascular therapy from january 2015 to december 2016 exclusion criteria: - age less than 18 years old
long-term outcome following concomitant surgical ablation for atrial fibrillation at university hospital basel: a retrospective study

Conditions: Atrial Fibrillation; Maze Procedure

Summary: this retrospective single-centre study aims to examine the success rate of concomitant surgical ablation in patients with atrial fibrillation (af) with an up to eight years follow-up period. moreover, the focus of this study was to identify variables which predict freedom from af, such as the type of af, lesion set performed, energy source used and the patient's characteristics.


Eligibility criteria:
inclusion criteria: * concomitant surgical ablation for atrial fibrillation * performed between january 2011 and january 2017 at university hospital basel exclusion criteria: * stand-alone procedure * surgical ablation for atrial flutter

Keywords: surgical ablation cardiac surgery
the feasibility and efficacy of an immersive virtual reality software in parkinson's disease patients

Conditions: Parkinson Disease

Summary: the dolphin 2.0 is a platform that runs an immersive virtual reality software, based on an oceanic environment, where players control simulated creatures (dolphin, orca, axolotl). video games lead to high levels of motivation and arousal, provide immediate feedback and playback, provide explicit reward and implicit success, and titrate difficulty levels. this encourages the practice of exercise, being an important complement to physiotherapy sessions. the main goal of this study is to evaluate the feasibility, safety and efficacy of an immersive virtual reality software (dolphin, 2.0) in parkinson's disease symptomatic control, in a two-arm, randomized, single-blind (blind rater for primary and secondary outcomes), delayed-start feasibility and efficacy trial.


Eligibility criteria:
inclusion criteria: * patients diagnosed with parkinson's disease according to mds criteria; * hoehn and yahr stages between i-iii (med on); * ability to perform the time up and go test in normal pace and without assistance, in less than 11,5 seconds in on state; * stable medication for the past 1 month * ability to communicate with the investigator, to understand and comply with the requirements of the study; * willing and able to provide written informed consent to participate in the study. exclusion criteria: * history of falls (1 fall in the 3 previous months); * psychiatric major co-morbidity (e.g., major depressive disorder as determined by dsm iv criteria); * a montreal cognitive assessment (moca) score \< 21; * significant visual or visual-perceptual deficits or neuropsychological impairments that may limit participation in the protocol; * having any other neurological/orthopaedic disorders likely to affect gait or exercise capacity, e.g., history of stroke; * unstable medical condition including cardiovascular instability in the past 6 months * interfering activities performed at high level (sports); * inability to correctly respond to the assessment protocol according to the clinician's judgment or lack of support from caregiver for this effect.
effects of growth hormone releasing hormone in hiv

Conditions: HIV; HIV Lipodystrophy

Summary: hiv-infection and its treatment are often associated with an increase in belly fat, as well as abnormal cholesterol and problems metabolizing sugar. people with hiv infection and increased belly fat often have decreased growth hormone (gh) levels. low gh levels may contribute independently to increased belly fat and to increased cardiovascular risk through effects on sugar metabolism, inflammation, and other mechanisms. tesamorelin, a growth hormone releasing hormone (ghrh) analogue, has been shown to to reduce belly fat in patients with hiv-associated abdominal fat accumulation. however, the effects of tesamorelin on fat accumulation in the liver and muscle, sugar metabolism, and cardiovascular health are not yet known. the current study is designed to determine the effects of tesamorelin treatment on fat accumulation in the muscle and liver, insulin sensitivity and sugar metabolism, and markers of cardiovascular health including blood vessel thickness (carotid intima media thickness \[cimt\]) and markers of inflammation in the body. the investigators hypothesize that tesamorelin will decrease fat accumulation in the liver and muscle and will decrease markers of inflammation, with either neutral or beneficial effects on glucose metabolism.


Eligibility criteria:
inclusion criteria: 1. men and women age 18-65 2. previously diagnosed hiv infection 3. stable antiviral regimen for at least 12 weeks prior to enrollment 4. wc\>95 cm and whr\>0.94 for male, wc\>94 cm and whr\>0.88 for female occurring in the context of treatment for hiv disease 5. subjective evidence of at least one of the following recent changes, occurring during the treatment of hiv disease: increased abdominal girth, relative loss of fat in the extremities, or relative loss of fat in the face 6. for female subjects 40yo or older, negative mammogram within one year of baseline exclusion criteria: 1. use of anti-diabetic agents, megace, testosterone or any steroid use within 6 months of the study. stable use of testosterone (\> 6 mos) at dose equivalent to 200 mg im q 2 weeks or \< 10g/day to skin will be permitted. 2. use of gh or ghrh within the past 6 months 3. change in lipid lowering or antihypertensive regimen within 3 months of screening 4. fasting blood sugar \> 126 mg/dl, sgot \> 2.5 times uln, hgb \ 1.4 mg/dl, cd4 count \< 200 5. severe chronic illness or active malignancy or history of pituitary malignancy or history of colon cancer 6. for men, history of prostate cancer or evidence of prostate malignancy by psa \> 5 ng/ml 7. prior history of hypopituitarism, head irradiation or any other condition known to affect the gh axis 8. for women, positive urine hcg 9. oral contraceptives, depo provera or combined progesterone-estrogen injections, transdermal contraceptive patches, estrogen or progestin coated iud's within 6 months of the study. 10. routine mri exclusion criteria such as the presence of a pacemaker or cerebral aneurysm clip.

Keywords: hiv lipodystrophy tesamorelin egrifta growth hormone releasing hormone
efficacy and safety of new generation drug eluting stents associated with an ultra short duration of dual antiplatelet therapy. design of the short duration of dual antiplatelet therapy with synergy ii stent in patients older than 75 years undergoing percutaneous coronary revascularization.

Conditions: Stable Angina; Silent Myocardial Ischemia; Acute Coronary Syndrome

Summary: the main objective of the senior study is to establish the efficacy and safety of the everolimus eluting stent with a biodegradable abluminal polymer (synergy ii) associated with a short dual antiplatelet therapy (dapt) in patients ≥75 years old, suffering from stable angina, silent ischemia (1 month dapt) or acute coronary syndromes (6 months dapt) related to significant coronary artery disease and requiring percutaneous coronary intervention. the primary end point is to demonstrate that synergy ii in patients ≥75 years old is associated with a lower rate of the composite rate of major cardiovascular and cerebrovascular events (all-cause death, myocardial infarction, stroke, ischemia-driven target lesion revascularization) and a similar risk of stent thrombosis than bare metal stent at one year.


Eligibility criteria:
inclusion criteria: * 1- patient is ≥ 75 years old * 2- one or more significant coronary artery stenosis is/are present (defined as ≥70% by visual assessment or ≥50% with fractional flow reserve \<0.80) or a left main coronary stenosis ≥50% by visual assessment) suitable for pci with one of the following present: * a -silent ischemia, * stress-induced myocardial ischemia ≥ 10% of myocardium in a asymptomatic patient or * stress-induced myocardial ischemia \< 10% of myocardium and ffr (fractional flow reserve) ≤0.80 or * b - stable angina, in a patient with objective ischemia despite optimal medical therapy or * c - acute coronary syndrome including: unstable angina, non st- and st elevation myocardial infarction. * 3- all patients must also sign informed consent as per local law and comply with all study process during follow up for at least one year. exclusion criteria: * 1- the subject is not eligible for randomization if any of the following is present: * 2- indication for myocardial revascularization by coronary artery bypass grafting, * 3- subjects unable to tolerate, obtain or comply with dual antiplatelet therapy for at least one month (stable angina or silent ischemia) or at least six month (acute coronary syndrome), * 4- subjects requiring additional surgery (cardiac or non-cardiac) within one month, * 5- non cardiac co-morbidities with life expectancy less than 1 year, * 6- prior hemorrhagic stroke, * 7- known allergy to aspirin or p2y12 inhibitors, * 8- at least one contra indication to all the authorized p2y12 inhibitors at the requested dose (in case of contra indication to only one of two of the p2y12 inhibitors, the investigators are allowed to use the p2y12 inhibitors for which no allergy is known). * 9- silent ischemia \<10% of the myocardium with ffr ≥0.80. * 10- participation in another clinical trial