Kornimate/medical-research-clean huggingface dataset:
satisfaction, pain and function outcomes of breast reduction patients

Conditions: Macromastia; Hypertrophy Breast

Summary: to explore the indications and benefits of breast reduction. the investigators suspect all of the patients in this population suffer from neck/back pain and limitations in function. the investigators also want to review the patients in this group to determine if the amount of breast tissue removed or previous breast size affects outcomes for these patients. patients will then be contacted for outcome data and satisfaction information. ultimately, this information may lead to improvements in management and education of patients with macromastia.


Eligibility criteria:
inclusion criteria: * females * ages 21-71 years-old * hypertropy of the breast * macromastia * post-surgical intervention for macromastia or hypertrophy of the breast exclusion criteria: * males * bmi\>40 * hypertrophy of the breast but without surgical intervention * macromastia but without surgical intervention
nordic study in newly diagnosed primary central nervous system (cns) lymphoma

Conditions: Central Nervous System Lymphoma

Summary: the purpose of the study is to test the efficacy and tolerability of a multiagent chemotherapy treatment regimen without radiotherapy in patients with newly diagnosed lymphoma in the brain.

the objective of the study is 1. to investigate the efficacy and safety of a high-dose methotrexate-based induction polychemotherapy regimen combined with rituximab and intraspinal depocyte followed by temozolomide maintenance treatment in newly diagnosed primary central nervous system lymphoma 2. to assess the long term outcome concerning neurotoxicity

Eligibility criteria:
inclusion criteria: * pathologically verified primary central nervous system lymphoma no prior pcnsl treatment. * patients treated with steroids alone are eligible * no signs of lymphoma outside the cns * ecog performance status 0-4 * age \> 17 and \< 76 years * written informed consent from the patient or guardian exclusion criteria: * cardiac failure \> 3 * pregnancy or lactation. women of childbearing potential are requested to use an effective method of contraception to avoid pregnancy for a period from entry to the study and at least 3 months after the last study medication * previous malignancy unless disease free for at least five years * active infection. * regarding tuberculosis, patients at risk should be tested for latent tb according local practice at each treating centre. * positive hiv status * organ transplantation * serious psychiatric illness * prior radiotherapy to the brain * concomitant anti-inflammatory medication that cannot be discontinued * creatinine clearance \< 60 ml/minute calculated by cockcroft and gault formula * peripheral blood count with granulocytes \<1.5 x 109l or platelets \< 100 x 109l * serum bilirubin \>1.5 times or asat and alkaline phosphatase \>2 times upper limits of normal. * known anaphylaxis or ige-mediated hypersensitivity to murine protein or any component of rituximab excludes patients from rituximab treatment, but not from the remaining part of the study

Keywords: pcnsl immunochemotherapy intraspinal depocyt maintenance temozolomide
client-centered counseling during routine/opt-out hiv-testing in uganda

Conditions: HIV; Sexual Behavior

Summary: this study pilot tests and intervention to help individuals reduce their risk for acquiring or transmitting hiv. the intervention is implemented when people are tested for hiv in an outpatient clinic in rural uganda. approximately half of participants will receive the intervention and the other half will receive the usual counseling provided during hiv counseling and testing.


Eligibility criteria:
inclusion criteria: 1. at least 18 years of age, 2. have come to the outpatient clinic for a medical concern (e.g., cough, malaria, but not those seeking voluntary hiv-counseling and testing, 3. sexually active within the prior 3-months, 4. not currently pregnant, 5. no confirmed hiv-positive test result prior to the present hiv-test, and 6. live not more than 30km from gombe hospital in uganda (to facilitate follow-up) exclusion criteria: * less than 18 years of age, * having come to the clinic seeking voluntary hiv-counseling and testing, * not sexually active in prior 3 months, * currently pregnant, * confirmed prior hiv positive test, * live more than 30km from the hospital
a year 2, safety extension study of the combination of abt-335 and statin therapy for subjects with mixed dyslipidemia

Conditions: Mixed Dyslipidemia

Summary: the objective of the study is to assess the continued safety of the daily coadministration of abt-335 in combination with rosuvastatin calcium, simvastatin or atorvastatin calcium.


Eligibility criteria:
inclusion criteria: * adult male and female subjects who voluntarily sign the informed consent. * subject has successfully completed the treatment phase of the preceding open-label year 1 study. exclusion criteria: * subject is using or will use investigational medications, except as approved by abbott. * subject has prematurely discontinued his/her combination therapy administered in the preceding open-label year 1 study.
the efficacy of scalp block in craniotomy

Conditions: Post-operative Pain; Narcotics Consumption; Pain Assessment; Intraoperative Hemodynamic Instability

Summary: the aim of the study is to compare the effectiveness and safety of scalp block versus intravenous fentanyl in pain control intraoperatively in craniotomy patients. most of the previous studies compared the effect of scalp block versus fentanyl or opioids in postoperative pain

the history will be obtained from patient. the patients fasting 8 hours preoperatively will be examined and assessed, especially neurologically, to exclude any neurological deficit that may affect the results. pre-operative laboratories will be reviewed for all patients as (complete blood picture, renal function tests, liver function tests, and coagulation profile) . patients will be assigned randomly by using a computer -generated table of random numbers, placing them in sealed envelopes, into two groups: * group a: (n= 10): patients will receive general anesthesia followed by intravenous fentanyl (1ug/kg/hr) * group b (control group): (n= 10): patients will receive general anesthesia then receive scalp block in the operating room, the monitor will be connected to track pulse oximetry (spo2), non-invasive blood pressure (nibp), and heart rate (hr). a second recording will occur after induction. an iv cannula will be inserted, and an electrocardiogram (ecg) obtained. pre-oxygenation with 100% oxygen will last 3 minutes, followed by iv induction with propofol (2 mg/kg), atracurium (0.5 mg/kg), and fentanyl (1 mcg/kg). the patient will be placed on inhaled isoflurane, and smooth intubation will be performed. invasive blood pressure monitoring will be set up via the non-dominant radial artery, and a central venous line will be inserted in the internal jugular vein using ultrasound. a scalp block will be done blindly for group b, while group a will receive fentanyl (1 mcg/kg/hr) prior to mayfield placement and skin incision. throughout the operation, continuous monitoring of electrocardiogram, heart rate, invasive blood pressure (ibp), oxygen saturation and urine output will occur. the scalp block will be performed under aseptic conditions by qualified personnel, with the patient in the supine position, using a landmark technique to target the relevant nerves for the blockage in group a.

Eligibility criteria:
inclusion criteria: * age between 20 and 60 * physical status: asa i and ii * elective operation, under general anaesthesia, exclusion criteria: * asa above ll * patients with known uncontrolled comorbidities such as hypertension or diabetes mellites * coagulopathy, use of anti-coagulant or anti-platelet therapy. * known allergies to drugs used (bupivacaine) * infection at the site of injection * history of cranial nerve affection * emergency craniotomy.

Keywords: scalp block pain craniotomy pain control
effect of lactose on blood lipids

Conditions: Cardiovascular Risk Factor; Lipaemia; Metabolic Disease

Summary: this study aims to determine to what extent ingestion of free sugars influence postprandial triglyceridaemia in men and women.

each participant will undergo three experimental trials in a randomized, crossover research design. on each study day, participants will consume a test drink containing standardised amounts of carbohydrate and fat followed by collection of blood and breath samples to assess metabolic responses during the 6 hour postprandial period. trials will be identical except for the type of carbohydrate contained within the test drink: 1) maltodextrin (glucose polymer), 2) lactose (galactose-glucose disaccharide) and 3) sucrose (fructose-glucose disaccharide).

Eligibility criteria:
inclusion criteria: • age: 18-50 years and premenopausal (for women) exclusion criteria: * weight instability (\>5 kg change in body mass within last 6 months) * diagnosis of any form of diabetes * intolerances or allergies to any of the study procedures (e.g. lactose intolerance) * galactose disorders (e.g. galactokinase deficiency, udpgalactose-4-epimerase deficiency, galactose-1-phosphate uridyl transferase deficiency) * fructose malabsorption * inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase b deficiency, fructose-1,6-bisphosphatase deficiency) * pregnant or lactating * any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).
validity, reliability and responsiveness of pain sensitization questionnaire

Conditions: Pain Syndrome; Pain, Chronic; Knee Osteoarthritis

Summary: the aim of this study was to translate the pain sensitivity questionnaire, which was developed to determine the level of pain sensitivity of individuals, to turkish and to evaluate the validity and reliability of the turkish version of the scale on knee osteoarthritis patients, and as well as to perform cultural adaptation. pain sensitivity assessment is used to predict treatment or surgical outcomes of individuals. ipain sensitivity questionnaire is a frequently used scale that correlates with experimental pain tests and is used in studies conducted in different patient groups. we believe that adding this scale to our language will contribute to other studies in this field.


Eligibility criteria:
inclusion criteria: * not having oral or written communication problems in turkish, * diagnosis of knee osteoarthritis after clinical examination and radiological imaging, * being 40 years or older, * to have neurological competence and cognitive level to answer scale questions. exclusion criteria: * to have fibromyalgia syndrome or neurological disease that may affect pain sensitivity levels of individuals, * to have undergone surgery involving the knee in the last 1 year, * the presence of peripheral neuropathy and neuropathy is therefore to be taking medication.
combination of antiplatelet and anticoagulation for ais patients witn concomitant nvaf and extracranial/intracranial artery stenosis

Conditions: Acute Ischemic Stroke; Atrial Fibrillation; Stenosis, Carotid; Intracranial Atherosclerosis

Summary: the goal of this clinical trial is to compare the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (ais) patients with concomitant non-valvular atrial fibrillation (nvaf) and extracranial/intracranial artery stenosis. participants will be 1:1 randomized into anticoagulation alone or anticoagulation combined with antiplatelet therapy. the primary endpoint is composite events 3 months after enrollment.

concomitant nvaf and extracranial/intracranial artery stenosis will greatly increase the risk of stroke, even with standard anticoagulation. however, clinicians may be concerned with the high risk of bleeding complications of anticoagulation combined with antiplatelet therapy. the goal of this clinical trial is to evaluate the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (ais) patients with concomitant non-valvular atrial fibrillation (nvaf) and extracranial/intracranial artery stenosis. participants will be 1:1 randomized into anticoagulation alone or anticoagulation combined with antiplatelet therapy. the primary endpoint is composite events 3 months after enrollment.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * acute ischemic stroke or tia with onset \< 7 days * have a history or newly diagnosed as nvaf * concomitant stenosis (\>50%) of carotid artery/intracranial artery, of which the ischemic lesion located within the territory exclusion criteria: * chronic renal dysfunction (gfr \< 30ml/min) or severe hepatic injury * have a history or newly diagnosed as valvular heart disease * mural thrombus in heart * contraindications of anticoagulation or antiplatelet therapy, e.g. severe intracranial hemorrhage * myocardial infarction within 6 months before enrollment or received percutaneous coronary intervention in the past * have or plan to receive cea or cas in the following 3 months * life expectancy less than 1 year * plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding * pregnant or lactating women * individuals identified by researchers as unsuitable for participation in the study due to other reasons.
concomitant use of gardasil (v501) (human papillomavirus [types 6, 11, 16, 18] recombinant vaccine) with combined diphtheria, tetanus, pertussis vaccine and meningococcal conjugate vaccine in adolescents (v501-025)

Conditions: Neoplasms, Glandular and Epithelial; Diphtheria; Tetanus; Whooping Cough; Meningitis

Summary: data from this study are expected to demonstrate that v501 (human papillomavirus (hpv) \[types 6, 11, 16, 18\] recombinant vaccine) , when administered concomitantly with a combined diphtheria, tetanus, pertussis (tdap) vaccine and a meningococcal conjugate vaccine in adolescents remains immunogenic and well-tolerated and it does not impair the immunogenicity of the concomitant vaccines.


Eligibility criteria:
inclusion criteria: * must be healthy boys or girls, 11-17 years of age * must be a virgin with no intention of becoming sexually active during the study period * must have been properly vaccinated against diphtheria, tetanus and pertussis exclusion criteria: * must not have received a vaccine against diphtheria, tetanus and pertussis in the past 5 years * must not have received any prior human papillomavirus (hpv) vaccine or meningococcal vaccine
exergaming for health: impact of a community-based active video gaming curriculum in pediatric weight management

Conditions: Pediatric Obesity

Summary: evaluation of the effectiveness of exergaming for health, a community-based multifaceted weight management program in a randomized controlled trial (rct). primary objective: to assess impact of the program on bmi z-scores. secondary objectives: to measure impact on cardiovascular fitness, self-worth, sedentary screen time, and the influence of exergaming component on attendance and participation.

eighty-four overweight pediatric subjects will be enrolled sequentially and randomized 2:1 in experimental and control groups for six months of weight management programming. the experimental group and their parents/guardians will participate in ten weekly 2-hour sessions, comprised of 1 hour of exergaming or exergaming combined with traditional exercise and 1 hour of didactic classes focusing on nutrition and psychosocial behaviors related to weight management. following these 10 weeks, they will attend monthly 1-hour maintenance didactic classes. the control group and their parents/guardians will participate only in the didactic portion of the curricula for the same duration of time, 10 weeks, followed by monthly maintenance classes for the remainder of the 6 month period. the control group will then be offered participation in the exergaming for health program upon study completion. comparisons between the two groups will be obtained through changes in the measurements of weight, height, bmi z-scores, shuttle run times, and responses to questionnaires about screen time, self-perception, and nutrition. measurements of both groups will be obtained at baseline and 6 months and another set of measurements will be obtained on the experimental group at 12 months.

Eligibility criteria:
inclusion criteria: * child with bmi greater than or equal to 85th percentile. * english speaking * approval by primary care doctor exclusion criteria: * participants with medical, developmental or psychiatric diagnoses which preclude participation in both the physical activity and classroom portions of the curriculum. * participants who are taking medications that positively or negatively affect weight.

Keywords: exergaming, weight management
investigation of laterality and sensory acuity abilities of frozen shoulder patients

Conditions: Frozen Shoulder; Laterality Defects

Summary: the brain contains the body representation necessary for normal functioning, including goal-directed movements and behaviors. body representation involves integrated sensory input and ideas about one's body. both executed and imagined movements depend on the representation of the body in the cortical area. laterilization is one of the motor imagery methods that requires activation of proprioceptive, somatosensory and premotor regions and enables the determination of pain-induced cortical changes. another method to determine pain-related somatosensory changes is the two-point discrimination test. it is suggested that laterization and sensory acuity responses may change due to long-term pain and stiffness experienced in people with frozen shoulders. therefore, the aim of this study is to investigate the laterization and sensory acuity abilities of patients with frozen shoulder.


Eligibility criteria:
frozen shoulder group: inclusion criteria: patients with shoulder pain of at least six months' duration secondary to tendinopathy and/or partial rotator cuff tear; patients with ability to follow simple orders; iii) patients with ability to sign to provide informed consent exclusion criteria: normal passive rom external rom \< 30 to have received treatment (physiotherapy, intra-articular injection, surgery) related to the existing complaint pain \< 3 according to the numbered pain assessment scale healthy group : inclusion criteria: no actual shoulder pain or previous history of shoulder complaints including frozen shoulder.
low-profile visualized intraluminal support -hud

Conditions: Giant Wide Necked Aneurysms

Summary: the microvention low-profile visualized intraluminal support (lvis\*) device is intended for use with bare platinum embolic coils for the treatment of unruptured, wide neck (neck greater than or equal to 4 or a dome to neck ratio less than two), intracranial, saccular aneurysms arising from a parent vessel with a diameter of greater than or equal to 2.5mm and less than or equal to 4.5mm.

wide neck aneurysms are very difficult to treat both surgically and endovascularly with clipping or coiling. the availability of this neurovascular flow diverter as a humanitarian use device has provided an additional approach to aneurysm occlusion using endovascular techniques.

Eligibility criteria:
inclusion criteria: * wide neck (neck greater than or equal to 4 or a dome to neck ratio less than two),intracranial, saccular aneurysm arising from a parent vessel with a diameter of greater than or equal to 2.5mm and less than or equal to 4.5mm.
tdcs associated with locomotor training on functional mobility of cerebellar ataxia

Conditions: Ataxia, Cerebellar

Summary: cerebellar ataxia is a neurologic symptom caused by a damage or a dysfunction in cerebellum and results in loss of coordination, balance and postural control. this impairment could result in a reduction of walking speed, short and irregular steps and difficulty in coordinating between lower limbs. pharmacological interventions are not able to modify ataxia gait pattern, therefore, new approaches to rehabilitate must be studied. treadmill locomotor training (tlt) and cerebellar transcranial direct current stimulation (ctdcs) are physical therapy techniques able to module cerebellar afferences and modify positively ataxia gait pattern. however, there is no study involving the association of these two techniques. the purpose of this study is to evaluate the effects of ctdcs associated to tlt on functional mobility in subjects with cerebellar ataxia. a randomized, sham controlled, double blind clinical trial will be performed. the subjects will be randomly allocated into two groups: (i) ctdcs associated with tlt; (ii) ctdcs sham associated with tlt. the tlt will be performed with a speed and step length progression protocol for 25 minutes. the anodal ctdcs (2 ma, 25 minutes) or sham (2ma, 30 seconds) will be applied during tlt. the functional mobility will be the primary outcome and will be evaluated through timed up and go test (tug). ataxia' severity, balance and fall risky, will be the secondary outcomes and will be evaluated by the scale for the assessment and rating of ataxia (sara), balance evaluation system test (minibest) and tug, respectively.


Eligibility criteria:
inclusion criteria: * cerebellar ataxia * ages: 18 to 65 years; * gender: both; * score ≥ 3 and \< 8 in subscore of gait in the scale for the assessment and rating of ataxia exclusion criteria: * individuals with other neurological disorders, postural hypotension, vestibular, visual, cardiovascular or musculoskeletal disorders that affect the performance of the proposed tests; * pacemaker; * history of seizures; * metallic implants in the head or neck; * medication change during the period of study

Keywords: cerebellum transcranial direct current stimulation gait ataxia
a study of avastin (bevacizumab) added to interferon alfa-2a (roferon) therapy in patients with metastatic renal cell cancer with nephrectomy

Conditions: Renal Cell Cancer

Summary: this 2-arm study will evaluate the efficacy and safety of avastin versus placebo in combination with roferon as first-line treatment in participants with metastatic renal cell cancer (clear cell type) who have had nephrectomy. the anticipated time of study treatment is 1-2 years, and the target sample size is greater than (\>)500 individuals.


Eligibility criteria:
inclusion criteria: * metastatic renal cell cancer (clear cell type); * nephrectomy; * absence of proteinuria. exclusion criteria: * prior systemic treatment for metastatic renal cell cancer; * major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to study treatment start; * presence of brain metastases or spinal cord compression; * ongoing need for full dose anticoagulants; * uncontrolled hypertension; * clinically significant cardiovascular disease.
pyruvic acid versus salicylic acid preparation in treatment of plantar warts

Conditions: Plantar Wart

Summary: plantar warts can be bothersome and painful requiring treatment. the investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. the number and size of warts will be evaluated.


Eligibility criteria:
inclusion criteria: * aged 12 years and above * multiple warts (at least 2) exclusion criteria: * mosaic warts * already under any treatment for warts * pregnant or lactating women

Keywords: wart verruca vulgaris topical therapy pyruvic acid salicylic acid