Kornimate/medical-research-clean huggingface dataset:
cb3 pilot (communication bridge: a person-centered internet-based intervention for individuals with primary progressive aphasia)

Conditions: Aphasia; Primary Progressive Aphasia; Dementia; Communication; Alzheimer Disease

Summary: this study will evaluate evidence-based treatments for adults with mild primary progressive aphasia (ppa). the aim of the study is to help identify efficacious communication and quality of life interventions for those with ppa and their care-partners. participants with a diagnosis of ppa and their actively-engaged care partners will be involved in the study for 12 months. each participant will receive a ipad equipped with the necessary applications and features for the study. participants will complete evaluations, speech therapy sessions with a speech and language therapist, and sessions with a licensed social worker or related clinician. they will have access to communication bridge, a personalized web application to practice home exercises that reinforce treatment strategies. there are no costs to participate in this study.

this study will evaluate evidence-based treatments for adults with mild primary progressive aphasia (ppa). the aim of the study is to help identify efficacious communication and quality of life interventions for those with ppa and their care-partners. participants with a diagnosis of ppa and their actively-engaged care partners will be involved in the study for 12 months. each participant will receive a ipad equipped with the necessary applications and features for the study. participants will complete evaluations, speech therapy sessions with a speech and language therapist, and sessions with a licensed social worker or related clinician. they will have access to communication bridge, a personalized web application to practice home exercises that reinforce treatment strategies. there are no costs to participate in this study.

Eligibility criteria:
inclusion criteria (person with ppa): 1. meets diagnostic criteria for ppa based on neurologist and supporting medical assessments (extracted from medical records) 2. english as primary language used in daily communication activities (by self-report) 3. adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report) 5. able to pass technology screening and demonstrates sufficient knowledge for use of video conference and communication bridge™ web application use (with or without training) exclusion criteria: * a dementia diagnosis other than primary progressive aphasia * participation is co-enrolled in an outside speech language therapy program during the study course. * communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia) medical records may be requested and reviewed to determine eligibility.
effects of group-based and individual pelvic floor muscle training on elderly individuals with urinary incontinence

Conditions: Urinary Incontinence

Summary: the purpose of this study is to asses the effects of 12-week group-based and individually planned pelvic floor muscle training on individuals aged 65 and over with urinary incontinence.

the research was conducted on participants over the age of 65 with urinary incontinence living in a nursing home. after these participants were informed about the content of the study, a signed informed consent form will be obtained. this study is an assessor-blinded, randomized controlled trial. participants with incontinence aged 65 and over living in a nursig home were randomly assigned to intervention (ig) and control group (cg). the intervention group attended an exercise program that individualized pelvic floor muscle with emg biofeedback training (individualized-pfmt). the control group was included in the group-based pfmt program. duration of exercise for both groups was 45-60 minutes per session three times a week for 12 weeks. incontinence symptoms and severity (pelvic floor distress inventory-20, bladder diary), pfm and abdominal muscle function (superficial electromyography), balance (berg balance scale), functional status (senior fitness test), hand grip strength, knee extansor, ankle dorsi-plantar flexion muscle srength, sleep quality and fear of falling (falls efficacy scale) was measured at baseline and after the intervention.

Eligibility criteria:
inclusion criteria: * having signed the informed volunteer consent form * being 65 years or older * having urinary incontinence * ability to walk unaided and not use any walking aids exclusion criteria: * having severe walking and balance problems * severe cognitive impairment (mini mental state assessment test score below * having a serious neurological problem * having serious heart diseases * having a genito-urinary infection * having pelvic organ prolapse * six months ago he received medication for incontinence * having had incontinence and abdominal surgery * having metastatic cancer * having any vision problems

Keywords: urinary incontinence pelvic floor muscle training elderly people elektromyography
digital-hf - digital tools in heart failure - a survey of patient usage (digital-hf)

Conditions: Heart Failure

Summary: heart failure is a chronic health condition associated with significant symptoms, an increased need of support from the nhs, and typically is associated with a reduction in life expectancy. the covid pandemic has made it more difficult for the nhs to deliver high quality care to the 1 million patients living with heart failure in the uk. nhs england plans that digitalisation of services will help, increasing efficiency and improving ability of patients to self-care and manage their conditions. "digitalisation" includes the use of digital tools for health, such as apps and online resources \& support. but the typical heart failure patient does not receive a diagnosis of heart failure until their 70s or 80s, creating a significant risk of digital exclusion. the heart failure failure community doesn't have any information about which tools (if any) heart failure patients are using, or why. patients who attend the heart failure clinic at the royal brompton, either face-to-face or virtually, will be eligible for our study. they will be provided an information sheet and asked for informed consent. the study consists of 4 short questionnaires (30 questions total) which only takes between 10-15 minutes to complete, this consists of 3 previously validated questionnaires and one bespoke questionnaire related to their digital tool use. the investigators aim to recruit 130 patients to help us better understand how many nhs patients with heart failure access digital tools, which ones are most often used, and how this relates to their health literacy, digital health literacy and overall attitude to their health condition and management. the investigators aim to describe different digital subgroups of patients and will use this information to help inform local and national policy around digital support for people living with heart failure.


Eligibility criteria:
inclusion criteria: * any patient who attends one of the heart failure clinics at the royal brompton hospital with a diagnosis of heart failure will be considered for the study. exclusion criteria: * unable to complete a questionnaire

Keywords: digital technology digital literacy patient activation measures
study of laparoscopic radical hysterectomy based on space anatomy in patients with ib3 and iia2 cervical cancer

Conditions: Locally Advanced Cervical Cancer

Summary: radical hysterectomy is an effect treatment for figo ib3 and iia2 cervical cancer patients who refuse to receive radical concurrent chemoradiotherapy. however, due to the large tumor size, both patients and surgeons encountered the risk of substantial bleeding, urinary tract damage, and unsatisfactory resection during surgery. therefore, the exploration of effective and safe surgical treatments is crucial in enhancing the quality of life and prognosis for patients. laparoscopic radical hysterectomy (lrh) offers the advantages of reduced bleeding and accelerated recovery, thereby minimizing patient discomfort and enhancing their quality of life. however, the prognosis of patients who received lrh or traditional abdominal radical hysterectomy (arh) remains controversial. we proposed a modified lrh skill based on new space anatomy concept. in our previous single-center study, the result demonstrates that lrh based on space anatomy leads to less intraoperative blood loss and decreased ureteral injury rate compared with traditional skill. the benefits of this new method for patient survival remain uncertain. in this multicenter retrospective study, we aim to assess clinical prognosis and safety of this new lrh compared with traditional abdominal radical hysterectomy (arh) in figo ib3 and iia2 cervical cancer.


Eligibility criteria:
inclusion criteria: 1. aged between 20 to 70 years 2. preoperative clinical diagnosis was figo 2018 stage ib3 or iia2 cervical cancer; 3. patients who received standard querleu-morrow type c radical hysterectomy (including arh or lrh based on space anatomy) and pelvic lymphadenectomy; 4. no preoperative suspected lymph nodes metastasis, parametrial involvement or lower 1/3 vagina involvement. exclusion criteria: 1. patients who had active double cancer or uncontrolled serious concurrent disease that might compromise prognosis; 2. pregnancy; 3. incomplete radical surgery; 4. follow-up time less than 6 months or lost to follow-up
urell and pregnancy

Conditions: Urinary Tract Infection (UTI)

Summary: evaluation of the effect of urell consumption on the occurrence of recurrent urinary tract infection (acute cystitis, pyelonephritis and asymptomatic bacteriuria).


Eligibility criteria:
inclusion criteria: - pregnant woman in her 4th gestational month or more, having urinary tract infection. exclusion criteria: * pregnant woman with organic or functional urinary tract malformations * diabetic patients * hiv positive
optimizing treatment on idiopathic inflammatory myopathies

Conditions: Idiopathic Inflammatory Myopathies

Summary: as a t2t, our patients with idiopathic inflammatory myopathies will receive pulse therapies with methyprednisolone and/or human intravenous immunoglobulin, or only methyprednisolone at disease onset. this scheme is an internal routine protocol of our service.

to compare two groups of patients as described in brief summary.

Eligibility criteria:
inclusion criteria: * idiopathic inflammatory myopathies exclusion criteria: * inclusion body myositis, muscular dystrophies, neoplasia-associated myopathies, overlapped myopathies, others myopathies

Keywords: dermatomyositis immunomodulation immunosuppressive agents myositis polymyositis necrotizing myopathies antisynthetase syndrome
coffee consumption for intestinal function recovery after laparoscopic gynecologic surgery

Conditions: Postoperative Ileus

Summary: minimally invasive surgery (mis) has revolutionized women's healthcare. laparoscopy is an excellent route of mis. today, laparoscopic surgery is one of the major procedure in the management of a gynecologic disease. it has revealed benefits of decreased morbidity, earlier discharged, and quicker return to normal daily activities, and shorter hospital when compared to abdominal approach. postoperative ileus (poi) defined as an uncomplicated ileus occurring following surgery, resolving spontaneously within 2 to 3 days. clinically, it is characterized by abdominal distension, a lack of bowel sounds, nausea, vomiting, stomach cramps, and lack of flatus. it leads to morbidity and delays in patient discharge from the hospital, leading to an increased economic burden on the healthcare system. that's why many researchers have focused on the prevent of postoperative ileus; many studies have investigated preventive approaches such as early mobilization of the patient, adequate pain control, epidural anaesthesia, hot pack therapy, motility agents such as metoclopramide, and alvimopan. although poi incidence has lower after the laparoscopic surgery it remains a major problem during the postoperative period. recent studies demonstrated that coffee consumption is associated with improved gastrointestinal function without worsening of postoperative morbidity for both open and laparoscopic surgery. however, until now, no studies investigating the effect of postoperative coffee consumption at laparoscopic gynecologic surgery. therefore, the investigators performed a randomized controlled trial to assess whether coffee consumption accelerates the recovery of bowel function after laparoscopic gynecologic surgery.


Eligibility criteria:
inclusion criteria: patients underwent total laparoscopic hysterectomy with or without additional surgery \*salpingo-oophorectomy, * salpingectomy, * pelvic and/or para-aortic lymphadenectomy exclusion criteria: * patients with hypersensitivity or allergy to caffeine/ coffee, * patients with thyroid disease, * patients with inflammatory bowel disease, * patients with compromised liver function, * patients with clinically significant cardiac arrhythmia, * patients with chronic constipation (defined as \< 2 bowel movements per week), * patients with a history of abdominal bowel surgery, * patients with previous abdominal irradiation, * the requirement for postoperative care in the intensive care unit \>24 hours postoperatively, * the requirement for nasogastric tube drainage beyond the end of the surgery * requirement bowel anastomosis * conversion to laparotomy.
acute study to evaluate a novel implantable midfield powered device in humans with urinary incontinence

Conditions: Overactive Bladder

Summary: a pre-market, prospective, non-randomized acute feasibility study for the treatment of patients with urinary incontinence (ui) as a consequence of urinary incontinence.


Eligibility criteria:
inclusion criteria: * subject was eligible for treatment and indication for the medtronic interstim system or interstim ii * subject wished to undergo an interstim or interstim ii implant procedure after this acute clinical investigation * subject was in good health in the opinion of the investigator * subject was able to understand and voluntarily signed and dated the ethics committee approved informed consent form prior to initiation of any screening or study-specific procedures * subject was minimum of 18 years and maximum of 65 years of age exclusion criteria: - subject had any of the contraindications for the interstim system or interstim ii system
single ascending dose study of safety and tolerability of sarilumab and methotrexate in japanese patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: primary objective: to assess the safety and tolerability of a single dose of subcutaneously administered sarilumab in japanese patients with rheumatoid arthritis (ra) who are receiving concomitant treatment with methotrexate. secondary objective: to assess the pharmacokinetic profile of a single subcutaneous (sc) dose of sarilumab in japanese ra patients.

total study duration per patient is up to 88 days 1. screening: 3 to 28 days 2. treatment: 1 day 3. follow-up: 57± 3 days after dosing

Eligibility criteria:
inclusion criteria: 1. male or female japanese who are 20 to 65 years of age 2. diagnosis of rheumatoid arthritis (ra) ≥ 3 months duration 3. treated for a minimum of 8 weeks with methotrexate (mtx) and with a stable dose of mtx (6-16 mg/week) for a minimum of 4 weeks prior to the screening visit exclusion criteria: 1. autoimmune or inflammatory systemic or localized joint disease other than ra 2. women of a positive pregnancy test 3. latent or active tuberculosis 4. prior treatment with anti-interleukin-6 (anti-il-6) or anti-interleukin-6 receptor (il-6r) antagonist 5. treatment with anti-tnf agents, as follows: 1. etanercept: within 28 days prior to randomization 2. infliximab, adalimumab, golimumab, certolizumab pegol: within 42 days prior to randomization 6. received any live, attenuated vaccine within 3 months prior to the randomization visit (eg, varicella-zoster, oral polio, rubella vaccines) 7. significant concomitant illness such as, but not limited to, cardiovascular, renal, neurological, endocrinological, gastrointestinal, hepato-biliary, metabolic, pulmonary or lymphatic disease that would adversely affect the patient's participation in the study. 8. received surgery within 4 weeks prior to the screening visit or planned surgery during the study 9. history of a systemic hypersensitivity reaction the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
intraoperative infusion of dexmedetomidine for prevention of postoperative delirium in elderly patients

Conditions: Dexmedetomidine; Postoperative Delirium

Summary: postoperative delirium (pod) is a common surgical complication. the incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures. many studies have shown that dexmedetomidine(dex) may reduce the incidence of delirium in non-cardiac surgery patients and elderly patients. however, there are few studies focus on the effect of dex on pod in elderly patients undergoing neurosurgery. the purpose of this study was to investigate the effect of dex on pod in in elderly patients undergoing craniotomy.


Eligibility criteria:
inclusion criteria: * patients undergoing selective craniotomy. * age ≥65 years. * obtain written informed consent. exclusion criteria: * operation time less than 2 hours. * refusal to provide written informed consent. * cognitive impairment before surgery(mini-mental state examination, mmse ≤ 26 or montreal cognitive assessment, moca≤22). * allergic to the study drug. * body mass index ≤18 or ≥ 30 kg/m2. * history of psychotropic drugs, anticholinergic drugs, antihistamine drug and dopaminergic drugs. * history of traumatic brain injury or neurosurgery. * severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block. * severe liver dysfunction (child-pugh grade c) or renal failure (requiring kidney replacement therapy). * the functional neurosurgery.
cleft palate surgical simulator: improvement in surgical trainees' knowledge and confidence.

Conditions: Cleft Palate Lip

Summary: trainees' experience in cleft surgery is limited due to the high-risk nature of the surgery and centralization of cleft care. simulations allow trainees to learn complex surgical skills whilst ensuring patient safety. existing cleft surgical simulators are over-simplified or prohibitively expensive. we developed and tested a high-fidelity yet cost-effective simulator for cleft palate repair. skeletal elements were obtained through high-resolution scanning of a pathologic specimen, 3d printed and then molded in plastic. soft tissue components were formed through molding layers of silicone. 26 uk specialty trainees performed a vomerine mucosal flap and intra-velar veloplasty in a one-hour workshop. pre- and post-simulation questionnaires assessing cleft knowledge and surgical confidence were compared for statistical significance.

background: trainees' experience in cleft surgery is limited due to the high-risk nature of the surgery and centralization of cleft care. simulations allow trainees to learn complex surgical skills whilst ensuring patient safety. existing cleft surgical simulators are over-simplified or prohibitively expensive. we developed and tested a high-fidelity yet cost-effective simulator for cleft palate repair. methods: skeletal elements were obtained through high-resolution scanning of a pathologic specimen, 3d printed and then molded in plastic. soft tissue components were formed through molding layers of silicone. 26 uk specialty trainees performed a vomerine mucosal flap and intra-velar veloplasty in a one-hour workshop. pre- and post-simulation questionnaires assessing cleft knowledge and surgical confidence were compared for statistical significance.

Eligibility criteria:
inclusion criteria: * plastic surgery training residents exclusion criteria: -
assist 2.0: a reablement program for healthy ageing

Conditions: Reablement; Frailty

Summary: the goal of this study is to continue to develop, implement, and evaluate a unique reablement service, assist 2.0. the project will determine the differences in the reablement service (assist 2.0) compared to regular home care in terms of older adults' performance in daily activities, self-efficacy, perceived health, quality of life, frailty and perceived person-centered approach. the research question is: can older adults receiving assist 2.0 improve their performance and satisfaction in daily life activities, experience a higher level of self-efficacy, perceived health, quality of life and a person-centered approach? the assist project involves older adults receiving home care, home care assistants, occupational and physical therapists. assist 2.0 reablement consists of the following components: * an intervention aimed at older adults to help them perform daily activities they need and want to do. this will be achieved through optimal support from home care staff, * an on-line education provided by the researchers for all staff in the art and science of reablement, * training and support through mentorship and coaching provided by occupational and physical therapists for home care staff to ensure the proper delivery of reablement.


Eligibility criteria:
inclusion criteria: * homecare has been granted * the person can describe an ordinary day and what they have problems with doing * 65 years of age or over exclusion criteria: • the person has palliative care
efficacy of low dose propofol given at the end of sevoflurane anesthesia for prevention of emergence agitation in pediatric patient undergoing mri scan

Conditions: Emergence Agitation

Summary: the goal of this clinical trial is to compare efficacy of low dose propofol(0.5 mg/kg) vs placebo given at the end of sevoflurane anesthesia for prevention of emergence agitation in pediatric patient undergoing mri scan. the main question it aims to answer is "can low dose propofol reduce the incidence of emergence agitation after general anesthesia?" participants will be given propofol 0.5 mg/kg or saline according to the allocated group at the completion of mri scan


Eligibility criteria:
inclusion criteria: * age 2-8 years * asa class i or ii ,who schedule for mri scan under sevoflurane anesthesia exclusion criteria: * developmental delay * psychological and neurological disorders * abnormal airway * reactive airway disease * allergy to propofol, egg product * family history of malignant hyperthermia * need iv sedative medication before induction * obesity