Kornimate/medical-research-clean huggingface dataset:
obesity childhood in cuenca-ecuador: prevalence and risk factors

Conditions: Obesity

Summary: hypothesis: obesity in children of cuenca is related with socioeconomical status and physical activity habits. summary: the prevalence of obesity and overweigh in all age groups are increasing rapidly in the world. some factors like physical activity, socioeconomical status, dietary habits, gender, besides genetic factors influence in the development of obesity. in cuenca - ecuador lack information related to prevalence of overweight and obesity in children and the risk factors related. socioeconomical status and quality of physical activity are assessed using specially designed questionnaires in a randomized sample of children 6 to 9 years of age of cuenca city. nutritional status is assessed using body mass index, relation weight/age and height/age. these data are helpful to develop programs focused to improve nutritional status in scholars of cuenca.


Eligibility criteria:
inclusion criteria: * all children of selected sample with an approved consent by their parents exclusion criteria: * children with malformations that not permit take anthropometric measures.

Keywords: nutritional status of scholars risk factors of obesity socioeconomical status physical activity habits
postprandial effects of milk and milk constituents

Conditions: Hyperlipidemia; Inflammation

Summary: the purpose of this study is to determine whether the addition of milk or the milk constituents calcium and protein to a high-fat breakfast affects the postprandial lipid and inflammatory response.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) above 27 kg/m2 exclusion criteria: * smoking * diabetes mellitus * cardiovascular diseases * familial hypercholesterolemia or lipid lowering medication * severe conditions that might interfere with the study outcomes, such as copd, asthma, rheumatoid arthritis, etc. * unstable body weight * abuse of alcohol or drugs * participation in another biomedical study during the past 30 days * having donated blood during the past 30 days

Keywords: milk postprandial hyperlipidemia postprandial inflammation overweight
effects of a hypoglycemia protocol with glucose gel on neonatal intensive care unit (nicu) admission

Conditions: Hypoglycemia; Neonatal Hypoglycemia

Summary: evaluate if the implementation of a hypoglycemia protocol with glucose gel has reduced the nicu admission rate of neonates with low-acuity neonatal hypoglycemia.

this project will evaluate various aspects of infants with hypoglycemia admitted to the neonatal intensive care unit (nicu) pre- and post- implementation of a hospital-wide hypoglycemia protocol with oral glucose gel. subjects will be matched by gestational age (ga), birth weight rounded to the nearest half kilogram, ethnicity, gender, maternal age, maternal diabetes status, maternal parity, maternal ethnicity, and mode of delivery. retrospective data will be reviewed including neonatal and maternal demographics and nicu medical course data. the results of this study can inform intended and unintended consequences of the instituted protocol.

Eligibility criteria:
inclusion criteria: * all neonates born at banner university hospital during january 01, 2014 - november 30, 2016 and january 01, 2018 - november 30 2018 who qualify for hypoglycemia protocol. exclusion criteria: * neonates \<34 weeks gestational age or with birth weight less than 2000 grams. * infants with serious congenital malformation * infants with a terminal disorder.
building research for intervention development in gliosis and eating habits

Conditions: Gliosis; Child Obesity; Eating

Summary: the goal of this study is to 1) use magnetic resonance imaging (mri) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious food feeding intervention strategies in children with overweight or obesity.


Eligibility criteria:
inclusion criteria: * study1: adult caregiver and child age 9-11y. willing to come to in-person focus group * study 2: age 9-11y, bmi ≥85th and ≤95th percentile for age and sex * study 3:adult caregiver with child who qualify for free or reduced-cost lunch in wa state. child age 9-11y and with overweight. exclusion criteria (study 1 child participants and study 3 criteria for children of adult participants): * significant health conditions including type 2 diabetes * history of major weight loss or eating disorder * current use of medications known to alter appetite or body weight (e.g., stimulants for adhd) * documented cognitive disorder * severe food allergies, vegetarian, or vegan (study 1 only) * unable to make the session date exclusion criteria (study 2, child participants): * significant health conditions including type 2 diabetes * history of major weight loss or eating disorder * current use of medications known to alter appetite or body weight (e.g., stimulants for adhd) * documented cognitive disorder * mri contraindication (e.g., braces, claustrophobia) * weight \>330 pounds (mri limit) * severe food allergies, vegetarian, or vegan * currently in formal weight loss program
evaluation of a flu vaccination program directed at pregnant women assisted at a research hospital in italy.

Conditions: Influenza Vaccination

Summary: influenza is a serious public health problem, which causes a high number of cases and deaths worldwide each year. in italy, about 8 million cases were reported in the 2018/2019 flu season, 809 of which were severe, with 198 deaths. pregnant women are considered one of the most at-risk groups, as infection can lead to serious complications for the mother and fetus. the italian ministry of health recommends free flu vaccination for pregnant women in the second or third trimester, as the vaccine is safe and effective in protecting the mother, fetus and newborn. during the 2018-2019 flu season, the fondazione policlinico universitario a. gemelli irccs (fpg) held an educational session on maternal and childhood vaccinations in the context of the childbirth preparation course held monthly at the fpg, offering the on-site flu vaccination to participants and their partners, if present. the objectives of this study are: to improve knowledge and attitudes regarding vaccination in the course participants, assessing their changes through a pre-post anonymous questionnaire; to evaluate the impact of the flu vaccination strategy implemented, through the analysis of vaccination coverage.


Eligibility criteria:
inclusion criteria: * attendance to the educational session about vaccination in the context of the childbirth preparatory course held at fondazione policlinico universitario "a. gemelli" irrcs exclusion criteria: * none
comparing efficacy and safety of insulin degludec/insulin aspart and biasp 30 in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. the aim of this trial is to compare efficacy and safety of insulin degludec/insulin aspart and biasp 30 in subjects with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any trial-related activities. trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial * male or female at least 18 years of age * type 2 diabetes mellitus (diagnosed clinically) for at least 6 months * insulin treated subjects on current treatment: basal insulin, premixed insulin or a self-mixed insulin regimen, all administered once daily (od) or bid with or without metformin. the treatment regimen should have remained unchanged for at least 8 weeks prior to randomisation * hba1c 7.0-10.0 % (both inclusive) by central laboratory analysis * body mass index (bmi) equal or below 40.0 kg/m\^2 exclusion criteria: * treatment with sulphonylureas, meglitinides, dpp-4 inhibitors, alpha-glycosidase inhibitors within 8 weeks prior to screening (visit 1) or thiazolidinediones (tzds) or glp-1 receptor agonists within 12 weeks prior to screening (visit 1) * anticipated change in concomitant medication known to interfere significantly with glucose metabolism, such as systemic corticosteroids, beta-blockers and monoamine oxidase (mao) inhibitors * anticipated significant lifestyle changes during the trial according to the discretion of the investigator, e.g. shift work (including permanent night/evening shift workers), as well as highly variable eating habits * cardiovascular disease, within the last 6 months prior to screening (visit 1), defined as: stroke; decompensated heart failure nyha1 class iii or iv; myocardial infarction; unstable angina pectoris; or coronary arterial bypass graft or angioplasty * any clinically significant disease or disorder, except for conditions associated with type 2 diabetes, which in the investigator's opinion could interfere with the results of the trial * previous participation in this trial. participation is defined as screened. * known or suspected hypersensitivity to trial products or related products
the relationship between social memory disorders and sleep spindles in children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: research background and project basis autism spectrum disorder (asd) is a lifelong neurodevelopmental disorder characterized by social disorders and repetitive stereotypical behavior. social memory impairment is a significant feature of asd patients, and the specific pathogenesis of social memory impairment in asd patients is currently unclear, and there are no objective indicators to measure social memory levels. sleep spindle wave is a special brain wave in sleep that is closely related to memory consolidation. however, no one has yet studied the impact of sleep spindles on social memory. research purpose exploring the correlation between sleep spindles and social memory in the population, providing reference for the auxiliary diagnosis of social memory disorders in children with asd.

the goal of this observational study is to exploring the correlation between sleep spindles and social memory in the population, providing reference for the auxiliary diagnosis of social memory disorders in children with autism spectrum disorders(asd). the main question it aims to answer is the effect of sleep spindles on social memory. the study clinically recruited 30 children with asd and 30 normal children. participants will be asked to take face and car recognition memory tests which car recognition memory test as a control. after the two tasks, nighttime eeg recordings and subsequent spindle analysis will be recorded and performed.then the correlation analysis between social memory levels and spindle levels would be conducted by machine learning model, so that researchers can infer the individual's social memory level through the level of spindles in the eeg.

Eligibility criteria:
inclusion criteria: * children with asd diagnosed through dsm-v (healthy controls do not have this requirement) * iq score ≥ 75（wisc-iv，wechsler intelligence scale for children） * age: 6-18 * not receiving psychotropic medication (or stopping medication for at least 2 weeks before the experiment) exclusion criteria: * in addition to asd, other mental illnesses are also combined * presence of a sleep disorder, sleep apnea, periodic leg movements during sleep, or atypical eeg patterns * left handed

Keywords: sleep spindles social memory deficits diagnosis
phase 2 clinical study in rheumatoid arthritis with an investigational oral p38 map kinase inhibitor vx-702

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to assess the clinical activity and safety of two doses of vx-702 compared to placebo in subjects with moderate to severe rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * adults with active rheumatoid arthritis for greater than 6 months and evidence of inflammation. exclusion criteria: * subjects who have conditions precluding the use of cytokine inhibitors or subjects who require dmards other than hydroxychloroquine or sulfasalazine are excluded.
role of intrapulmonary lymph nodes in patients with nsclc and visceral pleural invasion

Conditions: Lung Cancer; Lymph Node Metastasis

Summary: background: lung cancer is the leading cause of cancer related death worldwide. more than 80% of all lung tumors are non-small cell lung cancers (nsclc). lymph node staging has a prognostic value and is crucial to establish the optimal treatment strategy in individual patients. it remains unknown whether dissecting the intrapulmonary lymph nodes (stations 13 and 14) is necessary for accurate staging and prognostication. although suggested by several guidelines, these peripheral lymph nodes are not routinely examined in clinical routine for several reasons. moreover, the prognostic significance of the visceral pleural invasion is controversial. some studies showed a negative impact on os and dfs in patients with histologic proved visceral pleura invasion. the mechanism to explain this negative effect is not fully understood. given that the visceral pleura is very rich in lymphatic vessels, with an intercommunicating "network" arranged over the lung surface and penetrating into the lung parenchyma to join the bronchial lymph vessels with drainage to the various hilar nodes, we assume that the worse os and dfs observed in these patients could be explained with the presence of metastatic lymph nodes (station 13-14) that are not routinely examined. methods: this is a prospective, multicenter study based on ad-hoc created prospectively database. the incidence of n1 lymph node metastasis overall and the incidence of metastasis to the different lymph node stations (hilar 10/11, lobar 12, sublobar 13/14) will be calculated by dividing the number of the respective events by the patient years separately. to investigate the association between visceral pleural invasion and the presence of metastatic lymph nodes univariate and multivariate logistic regression models will be fitted to the data. discussion: the primary outcome is to investigate the incidence of n1 metastases (especially stations 12,13,14) and his relationship with visceral pleural invasion. the secondary outcomes is to evaluate the impact of n1 metastases and/or visceral pleural invasion on long-term outcomes (os and dfs) along with incidence and pattern of recurrence. dfs is defined as the time of surgical intervention to tumor recurrence or death, and os is defined as the time of surgical intervention to death


Eligibility criteria:
inclusion criteria: * anatomical resection for nsclc \<3 cm (lobectomy, bilobectomy, segmentectomy) * samples from the intrapulmonary stations 12, 13, and 14 lymph nodes * resection of lymphnodes station 10 and 11 during hilar separation. * r0 resection exclusion criteria: * prior or synchronous lung cancer * pn2 * pneumonectomy * r1/r2 resection * m1 * neoadjuvant treatment
turkish validity-reliability study of the diabetic foot self-care questionnaire

Conditions: Diabete Type 2; Diabetic Foot

Summary: the aim of this study is to evaluate the translation, cross-cultural adaptation and psychometric properties of the diabetic foot self-care questionnaire in patients with primary type 2 diabetes.

this study will be conducted in descriptive type. the population of the research will be patients with diabetic foot in the endocrinology clinic and polyclinic of the university hospital. the sample of the study will consist of patients who meet the research criteria and agree to participate in the research. the data collection tools of the study are the patient questionnaire (19 questions), the diabetic foot self-care questionnaire (16 questions) and the foot care behavior scale, by scanning the literature by the researchers. english turkish translations will be made before starting the research. afterwards, expert opinion will be taken for the suitability of the scale items. then, the turkish scale items will be translated back into english and the linguist's opinion will be taken that the scale can be applied. language and content validity will be done for the scale form. the scale items will be translated into turkish and expert opinions will be taken. then, the turkish scale items will be translated back into english and the linguist's opinion will be taken that the scale can be applied. language validity and content validity will be done in the study. explanatory factor analysis will be applied for the validity of the questionnaire. kaiser meyer olkin(kmo) test, which measures the adequacy of sample size as antecedent tests, and bartlett's test for sphericity will be used to test sphericity. factor analysis principal component analysis method will be applied.

Eligibility criteria:
inclusion criteria: * be over 18 years old * having type 2 diabetes and having a diabetic foot ulcer. * volunteering to participate in the research. exclusion criteria: * have a communication problem * presence of lower extremity amputation * presence of any ulcer other than diabetes

Keywords: diabete type 2 diabetic foot validity and reliability
diet in elderly with type 2 diabetes

Conditions: Sarcopenia; Sarcopenic Obesity; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes Complications

Summary: sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass which may affect performance. diabetes can affect muscle cell function, making sarcopenia worse. this is a prospective and interventional study on a elderly population affected by type 2 diabetes mellitus. all subjects, recruited will undergo tests for the diagnosis of sarcopenia according to the ewgsop2 criteria. all subjects, both sarcopenic and non-sarcopenic, will be introduced to a targeted nutritional program aimed at improving the composition of the diet, in terms of both micro- and macro-nutrients.

the sample will consist of about 100 subjects (50 sarcopenic and 50 non-sarcopenic) who receive the nutritional program. particular attention will be paid to the intake of an adequate protein intake for the elderly subject (1.1 g/kg/day). a food diary will be required to assess daily protein-calorie intake and questionnaires to assess daily physical activity and quality of life. the primary objective is to assess the efficacy of nutritional intervention in elderly affected by type 2 diabetes mellitus and sarcopenia. the secondary objective is to identify the prevalence of sarcopenia in patients with type 2 diabetes mellitus compared to non-diabetic subjects and to verify the relationship between pharmacological therapy and the presence of sarcopenia as well as evaluate any changes in style and quality of life and of glycometabolic compensation.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * bmi \>20 kg/m2 * hba1c ≥6.5% (48 mmol/mol) e ≤10% (86 mmol/mol) exclusion criteria: * t1dm or lada * patients with serious primary diseases of heart, brain, liver, kidney and hematopoietic system
observation of the incidence and natural history of mgus in patients undergoing weight reduction surgery

Conditions: Monoclonal Gammopathy of Undetermined Significance

Summary: screening study to determine incidence of mgus in this patient population

this study is designed to observe the incidence of monoclonal gammopathy of undetermined significance (mgus) among obese patients planning to have weight reduction surgery or planning to enter into a physician monitored weight loss program and to follow the regression or progression of mgus following surgery or the initiation of the weight loss program.

Eligibility criteria:
inclusion criteria: 1. male or female patients 30 years or older planning to undergo weight reduction surgery or planning to enter into a physician monitored weight loss program 2. patients must be obese, defined as a bmi ≥ 30 as calculated by the formula: weight in pounds / height squared x 703 = bmi 3. subject consent and authorization for the release of health information must be obtained according to local institutional guidelines. 4. to remain in the study for the follow-up phase, the baseline screening test must indicate that a patient has mgus. exclusion criteria: 1. no history of any malignancy except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for ≥ 5 years. 2. no concurrent or planned participation in randomized trials of weight loss. 3. a patient will be excluded from the follow-up phase if the baseline screening test indicates they do not have mgus
fascial distortion model manual therapy and painful shoulder syndrome

Conditions: Shoulder Pain

Summary: relatively new method of diagnosing and treating dysfunction of the musculoskeletal system is fascial distortion model. it is manual therapy developed by emergency physician and an osteopath stephen p. typaldos. disfunction are diagnosed based on verbal and physical descriptions, palpations, anamnesis. as a result of examination, it can be found one or more of six different distortions. the aim of the study is to examine the effectiveness of fdm manual therapy in comparison to manual therapy using the mulligan concept method and traditional physiotherapy in patients with shoulder dysfunction who have undergone previous rehabilitation and who have not achieved satisfactory results. patients will receive five treatments with one day brake between each treatment. the patient's condition will be evaluated before the first treatment, two weeks after the last treatment, and also after three months. as a outcome of the occurring phenomenon, structural changes are planned at the level of the fascial system in the studied region. the obtained results may influence the current views on diseases of the musculoskeletal system, as well as on the method of diagnosing and treating shoulder joint dysfunction.


Eligibility criteria:
inclusion criteria: * diagnosis of dysfunction in the shoulder joint based on an orthopedic and/or physiotherapeutic examination confirmed by x-ray and ultrasound imaging, * patients undergoing prior rehabilitation / pharmacotherapy / surgical intervention without satisfactory results, * limitation of mobility and / or pain in the shoulder complex, exclusion criteria: * coexistence of neoplastic diseases, * symptoms from the cervical spine * pregnancy, * aneurysms, * osteitis, * arthritis * deep veins thrombosis of upper limbs, * resignation from the study / therapy, * skin damage, hematomas.
remote ischemic preconditioning in coronary artery bypass grafting with cold crystalloid cardioplegic arrest

Conditions: Myocardial Injury

Summary: remote ischemic preconditioning (ripc) with transient upper limb ischemia/reperfusion reduces myocardial injury in patients undergoing on-pump coronary artery bypass (cabg) surgery with cross-clamp fibrillation or blood cardioplegia for myocardial protection. the present study assesses protection of heart, brain and kidney by ripc under crystalloid cardioplegic arrest. the study also addresses safety and clinical outcome.

remote ischemic preconditioning (ripc) protocol after induction of anesthesia and before skin incision consists of 3 cycles of 5 minutes left upper arm ischemia by inflation of a blood pressure cuff to 200 mmhg and 5 minutes of reperfusion. for myocardial molecular analyses, left ventricular biopsies are taken before induction of cardioplegic cardiac arrest and at 10 minutes after aortic unclamping during reperfusion of the myocardium.

Eligibility criteria:
inclusion criteria: * consecutive patients \>18 years of age * double- or triple-vessel coronary artery disease * elective isolated first-time cabg * combined valve surgery + cabg * written informed consent exclusion criteria: * renal failure (creatinine ≥ 200 µmol/l) * peripheral vascular disease affecting upper limbs * preoperative inotropic support * any kind of mechanical assist device * acute or recent (\<4 weeks) acute coronary syndromes * any pci (\<6 weeks) * any reasons for preoperative ctni elevation * emergency surgery * redo surgery

Keywords: remote ischemic preconditioning coronary artery bypass grafting myocardial injury