Kornimate/medical-research-clean huggingface dataset:
compare technegas ventilation-perfusion spect and xenon ventilation-perfusion planar imaging for pulmonary embolism

Conditions: Pulmonary Embolism

Summary: phase 3 within-subject trial of technegas v/q spect and tc-99m macro-aggregated albumin (maa) imaging compared to xenon-133 v/q planar and tc-99m macroaggregate of albumin (maa) imaging for the diagnosis of pulmonary embolism (pe).

this is a phase 3 within-subject trial of technegas ventilation spect and tc-99m maa perfusion imaging compared to xenon (xe-133) ventilation planar and tc-99m maa perfusion imaging for the diagnosis of pe. diagnosis of pe provided by review of the subjects' documented clinical information after 30 days of follow-up. primary assessments of efficacy will be based on an independent blind reads of the technegas v/q spect images by three different readers and the independent blind reads of xe 133 v/q planar images by three different readers.

Eligibility criteria:
inclusion criteria: subjects will be enrolled in cohort 1 if they meet the following requirements: 1. male or female, at least 18 years of age. 2. suspected of having pe and be a candidate for xe-133 v/q imaging. 3. willing and able to provide informed consent. 4. stable and able to undergo xe-133 planar imaging, technegas spect imaging, and planar/spect perfusion imaging and complete follow-up procedures. 5. willing and agree to complete study procedures, including follow-up safety assessments. 6. using adequate birth control, if female and fertile. 7. if female, has a negative urine or serum pregnancy test. 8. agrees to return for a 24-hour and 30 day follow-up safety assessment. subjects will be enrolled in cohort 2 if they meet the above criteria and subject is likely to have pulmonary embolism based on one or more of the following: 1. wells score of 7 or greater. subjects with a wells score less than 7 may be enrolled in cohort 2 if there is agreement between the investigator and the medical monitor that the subject is at high risk for pe. 2. an abnormal d-dimer test. 3. positive doppler ultrasound for dvt. 4. cta is positive for pe within 24 hours of this imaging study. exclusion criteria: subject 1. has undergone imaging with iodine-131 (i-131) within 30 days, thallium-201 (tl-201) or indium-111 (in-111) within 10 days, fluorine 18 (f-18) within 24 hours, or any other radiopharmaceutical not otherwise specified within 72 hours of this imaging study. 2. has previously undergone an imaging study with a tc-99m agent, within 48 hours of this imaging study. 3. is a pregnant or lactating female. 4. has received technegas in the past. 5. was previously enrolled in another investigational study or received an investigational drug within 30 days prior to dosing. 6. is hemodynamically unstable. 7. has received therapeutic dose of low molecular weight or unfractionated heparin within 24 hours prior to dosing or tissue plasminogen activator (tpa) within 4 hours prior to dosing or has received treatment for pe between the time of a positive cta, if performed, and technegas v/q spect imaging.

Keywords: pulmonary embolism pe
pharmacotherapy prescribing pattern and the adherence level to iron chelation therapy in thalassemia

Conditions: Thalassemia

Summary: thalassemias are a heterogeneous grouping of genetic disorders that result in dysfunctional hb, reduced rbc life span leading to chronic anemia . thalassemia is endemic in the middle east. iron chelation therapy (ict) is one of treatment used however ict is associated with patients adherence problem thus impacting its effectiveness .

thalassemias are a heterogeneous grouping of genetic disorders that result from a decreased synthesis of alpha or beta chains of hemoglobin resulting in dysfunctional hb, reduced rbc life span and hemolytic anemia as well as ineffective erythropoiesis leading to chronic anemia. thalassemia is endemic in the middle east, the mediterranean region, and southeast asia, its prevalence in these region range from 7%-10%. there are 3 iron chelators licensed for clinical use, namely, deferoxamine (dfo), deferiprone (dfp), and deferasirox (dfx). advancement in blood transfusions and ict transforms this disease from fatal childhood disease to adult chronic disease . from other side, thalassemic patients on ict suffering from therapy related challenge such as nonadherence, nonadherence to ict remains a long-standing and serious issue in thalassemia with ranges from 30% to 80% world widely. issue of nonadherence and suboptimal responsiveness to ict is complex and multifactorial such as side effects and administrations on top of inadequate knowledge and practice lead to reduced adherence to ict thus increasing morbidity and mortality

Eligibility criteria:
inclusion criteria: * male and female patients with age above 3 years old diagnosed with thalassemia, * having iron overload * taken iron chelation therapy * having the acceptance to participate in the study. exclusion criteria: * renal and hepatic impairment, * allergic to any drug of the study * history of viral hepatitis or hiv * gastrointestinal disorder affecting drug absorption. * psychiatric disorder affecting consent agreement and unable to comply with study.

Keywords: thalassemia prescribing pattern knowledge adherence
the family of heroes: an evaluation of an online educational tool

Conditions: Post Traumatic Stress Disorder; PTSD

Summary: the purpose of this study is to evaluate the effectiveness of a unique web based educational tool called "family of heroes," which is designed to educate families about post traumatic stress disorder (ptsd) and provide them with practical tools for interacting with affected veteran family members. the study includes veterans and a family member of their choosing. participants are randomly assigned to a group which takes the online training or a group that does not take the training. both groups complete a baseline questionnaire and a follow up questionaire 60 days later. the study will examine the number of veteran affairs (va) mental health visits.


Eligibility criteria:
inclusion criteria: * male or female operation iraqi freedom/ operation enduring freedom (oif/oef) veteran * positive for ptsd, based on ptsd checklist (pcl) score greater than or equal to 50 * availability of a family member who is both willing to participate in the study and has contact with the veteran 3 or more times per week * ability to access a computer with internet access to take educational training and surveys exclusion criteria: * not and oif/oef veteran * negative for ptsd, based on pcl score less than 50 * unavailability of a family member who is both willing to participate in the study or has contact with the veteran 3 or more times per week * inability to access a computer with internet access to take the educational training and surveys
internet tools and emergency attendance

Conditions: Emergency

Summary: over the years, there has been an increase in the flow of emergency rooms, which is gradually leading to an overcrowding of emergency unit. this overcrowding is multifactorial with, for example, a decrease in the outpatient care in family medicine and specialized medicine, emergency services unsuitable at the level of premises ... in parallel, investigator note in recent years facilitated access to internet and especially to gafa which is the acronym for google, amazon, facebook, apple. as a result, patients have 24-hour access to medical information via websites, blogs and social networks. this information of, often, unreliable medical information can lead to ambiguity among patients about the need for urgent or delayed intervention in the management of their symptoms. in fact, "everything becomes urgent". to date, in france, no study has evaluated the impact and prevalence of consulting a website for medical purposes before consulting an emergency service. the objective of this research will be to assess, in patients presenting in an emergency department, the prior consultation of medical information on a website, the impact on the emergency consultation decision and the relevance of this consultation.

it is an observational study, monocentric, prospective. this study consists in collecting data from an anonymized questioner given to patients presenting themselves at the emergency department of clermont-ferrand university hospital. answers to the questions will not change the patient's management. the questioner, containing 17 questions, requires answering "yes" or "no" by ticking boxes, or even specify when it is stipulated. this questionnaire will be given to the patient after his registration, and filled by the latter in the waiting room, pending medical care. answering the questionnaire will take between 5 to 10 minutes. the data is anonymous. the patient arrives at the emergency department and registers at the entrance desks where a paper and computer file is created. then, the reception and orientation nurse takes care of the patient by welcoming him in the reception box, she realizes the taking of the hemodynamics constants, the collection of the reason of consultation with the grievances of the patient. during this phase, patient will be inform of the completion of this study and asked to participate in this study. if the patient agrees to participate, an anonymized questioner will be provided and explained by one of the investigating physicians or associated partners.

Eligibility criteria:
inclusion criteria: * any major patient presenting to the emergency department by their personal way. exclusion criteria: * suspicion of acute alcoholism * dementia * guardianship / trusteeship * language barrier, non-communicating patient * patient refusing to participate in the study * patient with confusion * patient with glasgow scale less than 15 * patient not affiliated with social security * patient not knowing how to read or write.
effects of the concentrated extract of soy on coagulation factors after menopause

Conditions: Menopause

Summary: hypoestrogenism, common in menopause, is responsible for systemic and metabolic changes affecting women's wellness, favoring hot flashes, urogenital atrophy and bone mass loss. hormone reposition therapy (hrt) with estrogen or estrogen associated to progesterone is administered to minimize these effects. meanwhile, the beneficial effects of hrt are known, there is still concern about its adverse effects such as thromboembolic and cardiovascular effects, increased risk of breast and endometrial cancer. thus, there is an increasing interest in the development of phytohormonal hrt. the aim of the investigators' study is to evaluate the effects of concentrated extract of soy on hypercoagulation markers in menopausal women.


Eligibility criteria:
inclusion criteria: * \> 1 year of amenorrhea * 45 to 65 years old * without hormone reposition treatment or herbal medications in the 6 months preceding the research exclusion criteria: * history of thromboembolism * history of cardiovascular disease * presence of estrogen dependent neoplasia * presence of abnormal genital bleeding * uncontrolled metabolic diseases * smoking or drinking habits * use of anticoagulants or acetyl salicylic acid

Keywords: phytoestrogen coagulation menopause ddimer antithrombin hypercoagulation
infective endocarditis in developing countries, a prospective, observational, multicentre study

Conditions: Infective Endocarditis

Summary: introduction. comprehensive data on infective endocarditis in developing countries are scarce. objectives: description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries. methods : prospective, observational, multicentre study. inclusion criteria: patients aged over 1 year fulfilling the modified duke criteria for infective endocarditis. exclusion criteria: patient included during a previous infective endocarditis episode. outcomes measures: mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated. duration: one year (june 2014- june 2015)


Eligibility criteria:
inclusion criteria: * patients aged over 1 year diagnosed with infective endocarditis according to the modified duke criteria exclusion criteria: * already included for a previous episode of infective endocarditis (i.e., relapse or reinfection)

Keywords: infective endocarditis developing country global health cardiac surgery heart valve disease bacteremia
blood collection from individuals with lung disease for genetic studies

Conditions: Asthma; COPD; Interstitial Lung Disease; Cystic Fibrosis; Lung Cancer

Summary: this is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (copd), interstitial lung disease, cystic fibrosis, and lung cancer.

the investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. the findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. the investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.

Eligibility criteria:
inclusion criteria: * must provide informed consent * males and females, age 18 years and older * lung disease proven by at least one of the following: * symptoms consistent with pulmonary disease * chest x-rays consistent with lung disease * pulmonary function tests consistent with lung disease * lung biopsy consistent with lung disease * family history of lung disease * disease of organs with know associated with lung disease * individuals suspected of history of lung disease based on history and/or physical examination * normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort. exclusion criteria: * drug and/or alcohol abuse within the past six months * females who are pregnant or nursing
acute health effects of traffic-related air pollution exposure

Conditions: Cardiovascular System; Respiratory System

Summary: this study aims to assess the effects of acute exposure to traffic-related air pollution and the underlying mechanisms.

the investigators will conduct a randomized, crossover trial among 72 healthy young adults in shanghai, china. the eligible participants will be randomly divided into 2 groups (36 volunteers per group). during the first stage, participants will be requested to take one walking task (from 13:00 to 17:30). the exposed group will walk along a busy road and be exposed to traffic-related air pollution, while the control group will walk in a traffic-free park. during the first 3 hours, all participants will rest for 30 minutes after each 15-minute walking. from 16:00, participants will stop walking and rest for 1.5 hours. then both groups will enter a 2-week washout period. in the second stage, there will also be one walking task (from 13:00 to 17:30). the two groups will exchange their walking sites and repeat the previous trial. physical examinations will be performed both before and after each walking task. besides, we will ask volunteers to stay in school during the two days before walking. health examinations include symptoms questionnaires, blood pressure tests, holter monitoring, and spirometry. we plan to collect blood, urine, oropharyngeal swabs, and exhaled breath condensate before exposure, about one hour after exposure, and next morning.

Eligibility criteria:
inclusion criteria: * living in shanghai during the study period; * body mass index \> 18.5 and ≤ 28; * non-smoking, no history of alcohol or drug abuse; * completing the walking task we required. exclusion criteria: * current or ever smokers; * subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy; * subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension; * subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease; * subjects wih chronic disease, such as diabetes, chronic hepatitis, and kidney disease; * subjects with a history of major surgery; * abnormal spirometry (fev1 and fvc ≤ 75% of predicted and fev1/fvc ≤ 0.65); * medication use or dietary supplements intake in recent two months;

Keywords: traffic-related pollution randomized controlled trial acute health effects
a clinical trial of paclitaxel loaded polymeric micelle in patients with taxane-pretreated recurrent breast cancer

Conditions: Recurrent Breast Cancer

Summary: the purpose of this study is to evaluate the response rate in patients with taxane-pretreated recurrent breast cancer receiving paclitaxel loaded polymeric micelle (genexol-pm).

genexol-pm is a novel cremophor el-free polymeric micelle formulation of paclitaxel. this single arm, multicenter phase iv study was designed to evaluate the response rate, toxicity, progression free survival and tumor control rate of genexol-pm in patients with taxane-pretreated recurrence breast cancer.

Eligibility criteria:
inclusion criteria: 1. women aged \>=18 years 2. who (ecog) performance status 0-2 3. estimated life expectancy of \>=3 months 4. have given written informed consent and are available for prolonged follow-up exclusion criteria: 1. patients with previous chemotherapy for recurrent breast cancer 2. breast cancer recurrence within 12 months after taxane treatment 3. her-2/neu expression 4. patients with malignancies (other than breast cancer) within the last 5 years, except for adequately treated in situ carcinoma of the cervix or basal cell, squamous cell carcinoma of the skin. 5. brain metastasis 6. uncontrolled infection, medically uncontrollable heart disease 7. other serious medical illness or prior malignancies 8. pregnant or lactating women were excluded.

Keywords: recurrent breast cancer genexol-pm
dose-ranging safety and tolerability study in subjects ≥60 years of age

Conditions: Alzheimer's Disease

Summary: the study determined the safety of cnp520 in healthy elderly over 3 months. data relevant for pharmacokinetic/pharmacodynamic modeling were obtained in order to define the target dose in subsequent efficacy studies.


Eligibility criteria:
key inclusion criteria: * healthy status * body weight: ≥45kg * bmi: 18-34 kg/m2 key exclusion criteria: * history or presence of any clinically significant disease of any major system organ class. * heavy smoker status * history /presence of clinically significant neurological or psychiatric disorders * any medical condition that might lead to or is associated with any cognitive deficit * history or presence of severely impaired renal function

Keywords: alzheimer's disease, amyloid beta, cerebrospinal fluid, beta secretase
a clinical trial to study dr-2031 for the treatment of hot flashes in prostate cancer patients

Conditions: Prostate Cancer

Summary: this is a study to compare the efficacy and safety of 3 doses of dr-2031 to placebo when used as "add-on" therapy for prostate cancer patients with hot flashes following surgical or medical castration. all prostate cancer therapy must be stable for at least 45 days before entering the study and must remain stable throughout this 12-week study. patients will maintain a daily paper diary to record the frequency and severity of hot flashes during the treatment period.

this is a study to compare the efficacy and safety of 3 doses of dr-2031 to placebo when used as "add-on" therapy for prostate cancer in patients with mild to moderate vasomotor symptoms (hot flashes) following surgical or medical castration. all prostate cancer therapy must be stable for at least 45 days before entering the study and must remain stable throughout this 12-week study. to be eligible for this study prostate cancer patients must have undergone bilateral orchiectomy or medical castration utilizing lhrh analogues (lhrh agonists or lhrh antagonists) with or without additional antiandrogen therapy. patients must have at least 21 moderate to severe hot flashes weekly. patients will maintain a daily paper diary to record the frequency and severity of hot flashes during the treatment period. in addition, a brief physical evaluation will be done, diaries will be reviewed and any adverse events will be recorded at each follow-up evaluation.

Eligibility criteria:
inclusion criteria: * prostate cancer patients who have undergone chemical or surgical castration * history of hot flashes for at least 30 days * stable prostate cancer therapy for at least 45 days exclusion criteria: * uncontrolled diabetes or severe copd * history of thromboembolic disease * liver or kidney dysfunction * history or presence of cancer other than prostate cancer within the last 5 years * surgery within the last 3 months

Keywords: prostate cancer hot flashes hot flushes vasomotor symptoms
thermoregulation during a 25-km open water race

Conditions: Hypothermia Due to Cold Environment

Summary: open water swimming is a swimming discipline which takes place in outdoor water such as open oceans, lakes, and rivers. elite swimmers are exposed to hypothermia when swimming in cold water, especially in long duration races, such as the 25-km race. the objective of this study is to evaluate the change in body core temperature in swimmers with continuous temperature monitoring during a 25-km race. the secondary objective is to identify the predictors of hypothermia and hypothermia-related drop-out.


Eligibility criteria:
inclusion criteria: * competitors of the 25-km french open water championship * participants who volunteered for this study * written consent was obtained from all participants, as well as their legal representatives when applicable (i.e. parents for under age participants). exclusion criteria: * swallowing disorders * transit disorders * mri scheduled within 48 hours
cluster headache and spink-1 gene

Conditions: Episodic or Chronic Cluster Headache

Summary: cluster headache (ch) is a rare, excruciating primary headache disorder. a genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear. the number of genetic association studies investigating variants implicated in the pathophysiology of ch is limited. the hcrtr2 1246g \> a and the adh4 925a \> g polymorphisms have been associated with ch. the former has been confirmed and may affect the hypothalamic hypocretin system. the aim of the present study was to investigate the possible link between spink 1 gene and cluster headache.


Eligibility criteria:
inclusion criteria: * people aged 18 or over * patient consulting in marseille's or nice's pain departments * patient agreeing to participate to the research study * patient with health insurance exclusion criteria: * people aged under 18 * patient refusing to participate to the research study * patient with deprivation of liberty
a study to look at performance of micrusframe and galaxy coils for the treatment of intracranial aneurysms

Conditions: Aneurysms

Summary: a post-market registry evaluating ruptured/unruptured aneurysms treated with micrusframe and galaxy coils

a registry to collect real world data on the use of cerenovus coils. the study will be a post-market registry evaluating ruptured/unruptured aneurysms treated with micrusframe and galaxy coils

Eligibility criteria:
inclusion criteria: 1. patient is between 21 and 80 years of age 2. patient has an intracranial saccular aneurysm, ruptured or unruptured, suitable for embolization with coils 3. patient is able and willing to comply with protocol and follow-up requirements exclusion criteria: 1. pre-planned staged procedure on unruptured aneurysm 2. more than one aneurysm requiring treatment during the course of study 3. fusiform aneurysm