Kornimate/medical-research-clean huggingface dataset:
epithelial damage in gerd

Conditions: Gastro-esophageal Reflux Disease

Summary: the purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.


Eligibility criteria:
inclusion criteria: * typical gerd-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) * abnormal ph-parameters (pathological acid exposure and/or symptom association) exclusion criteria: * age \<18 years * previous esophageal or gastric surgery * severe esophageal motility disorder on manometry * histological evidence of barrett's mucosa * severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure) * use of anticoagulant or immunosuppressive drugs * inability to stop medication that can influence the test results, like ppi, for at least 10 days before tests * excessive alcohol consumption (\>20 units per week) * patients unable to give informed consent.
validity of ultrasound as regards correlation to cormack-lehane grading in obese patients

Conditions: Difficult Airway Intubation

Summary: since the introduction of real-time ultrasound (us) capabilities, ultrasound technology has been adopted and incorporated into daily practice by many medical and surgical specialties. using us to help assess the difficult airway constitutes just yet another valuable application of this versatile technology . since many anesthesia providers had already acquired proficiency in us techniques in us guided vascular access and regional nerve blocks, using us to evaluate the airway could be learned and mastered without too much difficulty. ultrasound of the upper airway may prove to become a useful adjunct to conventional clinical assessment tools, as it has been successful in visualizing the relevant anatomy and critical structures of the airway..

the study is cross sectional observational study in which obese patients will be assessed using conventional clinical methods of airway assessment and by using us for the same patient before induction of anesthesia then correlated to the cormack-lehane finding after induction of anesthesia..

Eligibility criteria:
inclusion criteria: * age of the patient : (21-60) years old. * sex : male \& female. * physical status : the american society of anesthesiologists (asa) ii-iii patients. * body mass index : 30 to more than 30 kg / m² . * operations: laparoscopic surgeries,bariatric surgeries and any operation that requires general anesthesia with endotracheal tube placement . exclusion criteria: patient refusal. * deformity of the airway anatomy \[by masses or tumors\]. * patients with thyroid swellings 'goitre'. * pathology of the airway \[edema,burn and arthritis\].
comparative study efficacy and safety of of activated versus non-activated prp

Conditions: Alopecia Areata

Summary: this was comparative prospective study conducted on 40 subjects, diagnosed with alopecia areata of 40 the scalp, carried in a period from february 2020 and march 2021

alopecia areata is a common recurrent t cell-mediated autoimmune-induced non-scarring hair loss with not fully understood pathogenesis which affects nearly 2% of the general population during lifetime. the course of the disease is unpredictable and currently, no treatment is available for complete cure or prevention. platelet-rich plasma is an autologous blood-derived product which widely spread in the last decades for the treatment of different dermatological conditions including different hair disorders. the aim of this work was to evaluate the efficacy and safety of activated platelet-rich plasma in comparison to non-activated platelet-rich plasma in the treatment of alopecia areata.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed clinically and dermatoscopically as alopecia areata of the scalp (uni- or 50 multilocularis). 2. age ranged between 18-50 years in both sex. exclusion criteria: 1. previously treated patients. 2. pregnant women. 3 patients with hematological disorders. 4. local infection at the site. 5. patients with hemoglobin \<10 g/dl and platelet count \<105/µl. 6. patients suffer from chronic and psychiatric diseases. 7.age below 18years or age above 50 years ago.
xenon against postoperative oxygen impairment

Conditions: Acute Lung Injury

Summary: acute lung injury (ali) is the vital complication of stanford type a aortic dissection. it is confirmed that xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. furthermore, our earlier trial has already clarified that static inflation with 50% xenon during cardiopulmonary bypass could attenuate ali for standford a acute aortic dissection. however the protection effect was restricted for the limited time. aimed to enhance the protection effect of xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after cpb and pulmonary static inflation with 50%,75% and 100% xenon during cpb respectively.


Eligibility criteria:
inclusion criteria consultant's clinical diagnosis of stanford type a aad using local pathways of diagnosis, which may include clinical history, chest radiography (x-rays), transthoracic ultrasound, and contrast-enhanced computed tomography (ct) or magnetic resonance imaging (mri) patients aged 18 to 65 years eligible for aad surgery exclusion criteria have coronary heart disease, heart failure, severe cardiac tamponade, unstable hemodynamics, severe nervous system abnormalities, clinically apparent malperfusion\[9\] including lower limb, cerebral, coronary and renal malperfusion, and visceral ischemia, sever hepatic and renal abnormalities have undergone any of the cardiac and thoracic surgeries are unlikely to be able to perform the required clinical assessment tasks have significant cognitive impairment or language issues are unable to provide consent with regard to their participation in the study prescribed with non-steroidal anti-inflammatory drugs or corticosteroids before or after admission

Keywords: xenon standford a acute aortic dissection
endometrial effects of lipiodol

Conditions: Female Infertility

Summary: the goal is to investigate whether endometrial flushing with lipiodol enhances fertility. therefore, anatomo-pathological, histochemical and transcriptional changes of the endometrium after lipiodol bathing in a general population of healthy volunteers will be determined.

a single-centre, cross-over, open-label trial will be performed. healthy volunteers, fulfilling the inclusion/exclusion criteria, will be asked to do blood samples and ultrasounds for the detection of the lh (luteinizing hormone) surge in a natural cycle. the intervention group will undergo endometrial flushing with lipiodol between day 6 and 8 of the cycle, while the control group between day 6 and 8 of the cycle will have a mock catheter introduction without any lipiodol flush. an endometrial biopsy will be performed 7 days after the lh peak in all the participants. furthermore, all the participants will undergo one cycle with flushing and one cycle with introduction of a mock catheter but without flushing with any medication. the wash-out period between the 2 biopsies will be 3 months.

Eligibility criteria:
inclusion criteria: * women aged ≥18 and \<36 years * regular cycle (25-35 days) * signed informed consent * participants can be included only once in the trial * contraceptive: barrier method only. exclusion criteria: * known iodine allergy * body mass index 30 or ≤18.5 * smoking * previous diagnosis of pco (polycystic ovary syndrome) (\>12 antral follicles in one ovary, rotterdam criteria 2003) * previous diagnosis of endometriosis, uterine malformations or intrauterine pathologies (submucosal fibroids, endometrial polyps, and intrauterine adhesions) * systemic diseases such as thyroid dysfunction * breast-feeding or pregnancy within the last 6 months * intrauterine devices (iud) * history of recurrent miscarriage * known history of infertility * previous uterine surgery * pregnancy wish during the course of the study * women who have been previously enrolled in the trial * those unable to comprehend the investigational nature of the proposed study
a new surgical approach to treat medial or low condylar fractures

Conditions: Fracture of Condylar Process

Summary: the aim of the study was to compare the new approach and the retromandibular approach, so that the therapeutic effect and the advantages of the new approach would be clear.

sixty patients (72 sides) with medial or low condylar fractures were treated with surgical intervention. thirty-six patients (42 sides) were treated with minor parotid anterior approach, and the other 24 patients (30 sides) were treated with retromandibular approach. the data about the operations and complications were recorded. the follow-up periods were 3-12 months.

Eligibility criteria:
inclusion criteria: * (1)clinical and imaging diagnosis of medial or low condylar fractures * (2)bone fragments that were obviously dislocated, that affected patients appearance and function, requiring surgical intervention * (3)no previous surgical treatment exclusion criteria: * (1)medial or low condylar fractures without obvious displacement * (2)patients who had previously undergone unsuccessful surgery * (3)the surgical site had traumatic scar, so the approach could be carried out on the original incision

Keywords: medial or low condylar fractures the minor parotid anterior approach the retromandibular approach
furosemide versus ethacrynic acid in children with congenital heart disease

Conditions: Fluid Overload

Summary: this study aims to verify if ethacrynic acid continuous infusion is superior to furosemide continuous infusion in total urine output production during the first 24 post operative hours.

diuretic therapy in children after open heart surgery is widely administered, though no evidence currently supports if an ideal drug or an ideal dosage can be recommended. loop diuretics are the most effective drugs in terms of urine output production but may cause some collateral effects such as metabolic alkalosis, hypovolemia, hypokalemia, ototoxicity. furthermore, some reports showed that loop diuretics usage can be associated with an increased risk of renal dysfunction and mortality. however, their use in children with signs of fluid overload, pulmonary edema or oliguria is mandatory and widely practiced. furosemide and ethacrynic acid are often prescribed and administered without any specific indication, basing on clinicians preferences. no study so far, explored the hypothesis of which of these drugs is the most effective in terms of urine output production and safe in terms of renal function. this study aims to verify if ethacrynic acid continuous infusion is superior to furosemide continuous infusion in total urine output production during the first 24 post operative hours.

Eligibility criteria:
inclusion criteria: * children with congenital heart disease undergoing cardiac surgery * intraoperative aortic cross clamp over 90 minutes or interventional catheterization procedures with post-operative inotrope score over 20 * sign of fluid retention after surgical procedures exclusion criteria: * preoperative renal dysfunction * preoperative administration of more than 4mg/kg/die loop diuretics * need for renal replacement therapy at icu admission * need for ecmo at icu admission

Keywords: loop diuretics fluid balance urine output acute renal dysfunction
effect of nanotechnology structured water magnalife for the prevention of recurrent urinary tract infections.

Conditions: Recurrent Urinary Tract Infection

Summary: this study investigates nanotechnology structured water magnalife in urology and to test its effects against lower urinary tract infections (uti) in females.

this study represents the first time to use nanotechnology structured water magnalife in urology and to test its effects against lower urinary tract infections (uti) in females. urinary tract infection (uti ) is the second most common bacterial infection, affecting women at a much higher frequency than men. there is a higher rate of recurrence of uti, and a recurrent infection will follow 25-35% of initial uti episodes within 3-6 months. intermittent or prolonged low dose antibiotic therapy has been used to treat and prevent recurrent uti. emerging of resistance to antimicrobial agents, enormous economic burden, and the side effects of antibiotics have led to the search for an alternative non-antibiotic prophylaxis of recurrent uti. nanotechnology structured water is a new type of drinking water that has been prepared using different types of energy fields and electromagnetic fields to produce this structured water, which has new and different characteristics from the ordinary water. in the current study, the efficacy of nanotechnology structured water magnalife was compared with low-dose trimethoprim and bottled drinking water for the prevention of recurrent uti.

Eligibility criteria:
inclusion criteria: * ≥ 2 (two or more than two) uti in the last 6 months * ≥ 3 (three or more than three) uti in the last 12 months exclusion criteria: * immunotherapy * radiotherapy * malignancy * steroids * chronic infections * chemotherapy * immunosuppressive drugs * anatomical abnormality of the urinary tract * surgical operation the urinary tract

Keywords: nanotechnology water, antibiotic prophylaxis, recurrent uti.
jikei optimal insulin therapy in type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to compare whether there is the difference in the effect of insulin therapy by the number of times of insulin injection.

the current insulin therapy is divided into the conventional insulin therapy (1\~2 injections per day) and the intensive insulin therapy (3\~4 injections per day). the kinetics of exogenous insulin in the intensive insulin therapy imitate the kinetics of insulin secretion in a healthy person. a previous large clinical study (e.g. dcct, kumamoto study, etc.) suggested that intensive insulin therapy prevented microangiopathy and macroangiopathy, and inhibited progression of them, however many patients chose conventional insulin therapy because many hoped that they injected insulin as few as possible. the patients thought that their life styles were disturbed by many times of insulin injection. the current dual-acting insulin made from insulin as part modified by protamine is able to suppress postprandial hyperglycemia. the new insulin may possibly have the kinetics of insulin in the patient who uses insulin as the intensive insulin therapy. moreover, the patients will receive the insulin therapy easily if the times of insulin injection are fewer. it may lead to perform the more effective insulin therapy to search for the optimal insulin therapy in induction in type 2 diabetes. comparison:hba1c, glycated albumin, imt, lipid profile,body weight, daily profile of blood glucose,between the conventional insulin therapy and the intensive insulin therapy.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2 diabetes * secondary failure of su drug * whose age is to 80 from 20 years old exclusion criteria: * who has the complication * who has a allergy of insulin * who is pregnant

Keywords: diabetes mellitus, biphasic insulin analogue
improving adherence to home blood pressure monitoring with pharmacist support

Conditions: Hypertension

Summary: the purpose of this research study is to evaluate the impact of monitoring blood pressure from home everyday with pharmacist support.

high blood pressure is very common and increases risk of heart, kidney, brain, and eye disease. it is important to diagnose and treat high blood pressure to reduce risk of these complications. getting blood pressure checked only when someone sees a doctor is not the best way to diagnose high blood pressure or to make sure blood pressure is well managed. checking blood pressure at home gives a better idea of whether someone's blood pressure is normal or too high. as part of their usual blood pressure monitoring, participants will be given an omron 3 series or 5 series blood pressure monitor which has been cleared by the us food and drug administration and validated to meet accuracy and performance requirements. for one month, participants will monitor their blood pressure once a day and then return the device to the clinic at the end of the study. participants will text their blood pressure result to the american heart association's check, change, control (ccc) secure online tracker. as part of the research study, participants will also be randomized to either receive or not receive weekly check-in phone calls from a pharmacist to review their blood pressures and the number of times they tested in that week. approximately 50 individuals will participate in this study. participation in this study will last 1 month.

Eligibility criteria:
inclusion criteria: * 18 years of age and older * uncontrolled hypertension (bp \> 130/80 mm hg) exclusion criteria: * non-english speaking patients * patients without a mobile phone or texting capability
effects of different concentrations of pressurized-heparin flushing fluid on coagulation and platelet function monitored by the sonoclot analyzer

Conditions: Heparin; Perioperative

Summary: heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. in this research, the coagulation and platelet function analyzer called sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.


Eligibility criteria:
inclusion criteria: * diagnosis of gastrointestinal cancer * ages ranged from 18 to 75 * asa i\~iii exclusion criteria: * pregnancy * modified allen test negative * history of taking anti-platelet drugs such as aspirin one week before surgery, heparin allergy and thrombotherapy * two failed catheterizations of the same artery * significant diseases in liver and kidney function * refusal of patients
clinical application of wearable ultrasound sensors

Conditions: DVT - Deep Vein Thrombosis; POCUS

Summary: this study aims to develop and evaluate a wearable ultrasound imaging sensor for the early diagnosis and real-time monitoring of various diseases, such as cardiovascular conditions and structural abnormalities of superficial organs. with advancements in medical technology, wearable devices have attracted increasing attention for their portability and real-time capabilities.


Eligibility criteria:
inclusion criteria: * age ≥ 18 yrs and able to consent * relevant diagnosis for study arm (heart failure, lower-limb dvt, or icu monitoring) * adequate acoustic window and intact skin at sensor site arm-specific: * heart-failure arm: clinically stable hfref or hfpef on standard therapy * dvt arm: imaging-confirmed lower-limb dvt, anticoagulated or scheduled for intervention * icu arm: icu/post-op patient requiring continuous bedside ultrasound exclusion criteria: * poor acoustic window preventing interpretable images * local skin infection, open wound, or implant/hardware blocking sensor * inability to cooperate with monitoring arm-specific: * heart-failure arm: acute mi or uncontrolled arrhythmia in past 3 months * dvt arm: active bleeding or severe coagulopathy * icu arm: unstable multi-organ failure precluding safe monitoring
sub-study of the essen study centre for the entaier trial

Conditions: Elderly Patients; Chronically Ill; Increased Risk of Falling

Summary: the present study is a sub-study of the entaier study. the entaier study is a multicenter, randomized, controlled study to evaluate the efficacy and safety of eurythmy therapy and tai chi in comparison to standard care in chronically ill older patients with an increased risk of falling. in addition to the main questions of the entaier study, three additional questions are being investigated at the hospital essen-steele: proteome and telomere analyses as well as qualitative parameters are recorded and examined. the aim is to compare the changes in proteomes, telomeres and qualitative factors under eurythmy therapy, tai chi and standard care in chronically ill older patients with an increased risk of falling.


Eligibility criteria:
inclusion criteria: * at least 65 years. * chronic disease (musculoskeletal, neurological, internal medicine). * increased risk of falling (berg balance scale score 49 or less). * medical history: feeling of balance disturbance in the past. * independent living at home or in an old people's or retirement home. * regular participation in a one-hour event is possible. * sufficiently mobile to leave the place of residence independently at least twice a week * written declaration of consent. exclusion criteria: * disease that restricts participation (e.g. terminal disease, heart failure nyha iii-iv, unstable angina pectoris, uncontrolled seizure disorder, decompensated lung disease that already leads to shortness of breath during light activity, advanced cancer, chemo- or radiotherapy ongoing or during the last 3 months, amputation of one or both legs) * complete dependence on the rollator. * visual, hearing or speech problems that limit the understanding of the study documents and processes. * major cognitive impairment (moca score 18 or less). * high risk of needing individual supervision during group sessions. * severe personality disorder or psychiatric illness, alcoholism or other substance dependence affecting the group sessions. * life expectancy under 1 year. * permanent bed-riddenness expected in less than one year. * regular participation in tai chi or eyt in the last 6 months. * participation in intensive sports activities in the last month (e.g. training in the fitness centre or in sports groups which lead to breathlessness and sweating; skiing, mountaineering in high mountains). * patients who cannot understand the nature, meaning and necessities of participating in a study. * participation in another clinical trial within 3 months prior to screening for the entaier trial or concurrent participation in another trial that may interfere with this trial.