Kornimate/medical-research-clean huggingface dataset:
group cbt for ppd in the public health setting

Conditions: Depression, Postpartum

Summary: postpartum depression (ppd) affects over 14,000 women in ontario each year and can have profound effects on mothers, their children, and their families. the cost of one case of ppd exceeds $150,000, a significant proportion of which is related to its impact on offspring. however, difficulties accessing preferred treatments (e.g., psychotherapy) result in fewer than 15% of women receiving care. while public health units have played an important role in ppd detection in ontario, public health nurses (phns) currently lack the skills to deliver evidence-based treatment to women. cognitive behavioural therapy (cbt) delivered in group format is effective for treating depression in the perinatal period, and as phns are often the first point of contact for women experiencing ppd, with specialized training it is likely that they can deliver high-quality cbt. the primary objective of this study is to determine if phns can be trained to deliver group cognitive behavioral therapy (cbt) to acutely treat ppd, reduce relapse and recurrence, improve mother-infant attachment and parenting and optimize infant emotional functioning.

in addition to its effects on maternal health, ppd can adversely affect mother-infant attachment, parenting, and the development and health of her children. the negative effects of ppd on offspring can include an increased risk of insecure attachment, poorer cognitive, language, and behavioral development, as well as an increased risk of emotion regulatory problems. to determine if phns can effectively deliver group cbt for ppd that is superior to postnatal care as usual, the investigators will proceed with a randomized controlled trial (rct). women in the treatment group will attend a 9-week group cbt intervention delivered by trained phns. those in the control group will receive standard postnatal care. this rct will compare the effects of group cbt to postnatal care as usual on maternal depression, anxiety, mother-infant attachment, parenting, healthcare utilization and social support, as well as infant development, emotion regulation, and healthcare utilization

Eligibility criteria:
inclusion criteria: * eligible women will be \>18 years of age, understand and speak english (so that they can participate in the cbt group and complete study measures), have an epds score between 10 and 23. they will also all be within 12 months of delivering an infant exclusion criteria: * women can have psychiatric comorbidities with the exception of bipolar disorder, a current psychotic, substance or alcohol use disorder, or antisocial or borderline personality disorder.

Keywords: postpartum depression cognitive behavioral therapy public health mother infant emotion
evaluation of transition with a heart, a transition program for adolescents with congenital heart disease and parents

Conditions: Congenital Heart Disease in Adolescence; Transitional Care

Summary: the department of congenital heart disease of the ghent university hospital (belgium) developed a transition program dedicated to adolescents with congenital heart disease (chd): 'transition with a heart´ (twah). twah was developed based on the dutch program 'on your own feet´, starting at the age of 12 years and continuing after transfer. the most vital core components include a general and individualized flowchart, adolescent-centred communication, a joined transfer consultation and an appointed transition coordinator. twah focuses on promoting disease knowledge, autonomy and skills development of adolescents with chd. interventions encompass the use of a communication-paper, autonomously talking to professionals, individualized education and skills development plan. interventions were selected from the highest sources of scientific evidence currently available including (quasi-) experimental studies, narrative literature reviews and expert opinions. twah is the intervention in the conducted study. hence, the intervention group are adolescents with chd and their parents who are participating in twah. adolescents and their parents who are transferred according to standard care (joined transfer consultation only) are identified as the control group and will be examined in the post test phase in order to be able to make comparisons with the intervention group. at baseline (the start of twah) participants of the control group already made the transfer to the adult ward. the investigators consider the following hypothetical scenario: - twah will have a positive influence on disease knowledge and transition experiences of the participants.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of a chd of great or moderate complexity (6) * from the age of 12 years or older * must be able to complete the questionnaires * dutch speaking and/or * parents having children who are meeting the inclusion criteria above exclusion criteria: -

Keywords: transitional care
muscular activations during eccentric quadriceps exercises

Conditions: ACL Injury; Sport Injury; Sports Physical Therapy; Muscle Weakness

Summary: the aim of this study is to investigate muscular activations during various quadriceps exercises commonly used in clinical settings.

the quadriceps muscle is known to be crucial for the dynamic control of the lower extremity, and weakness in this muscle can lead to strategies that may result in injury. therefore, acquiring optimal quadriceps muscle strength is essential not only for preventing lower extremity injuries but also for enabling individuals to fully return to activities after an injury. despite the existence of various eccentric quadriceps exercises in the literature, there is a lack of consensus on their comparative effectiveness. hence, there is a requirement for research to explore the effectiveness of different eccentric quadriceps exercises. the objective of this study is to compare the muscular activation of the quadriceps muscle during four distinct eccentric quadriceps exercises using surface electromyography (semg) devices

Eligibility criteria:
inclusion criteria: being a licensed athlete in one's own field, having been engaged in sports for at least 2 years exclusion criteria: individuals with any musculoskeletal injury history in the lower extremities and trunk that could impede exercise within the last year, individuals with systemic, neurological, and/or cognitive issues, individuals experiencing pain in the lower extremities and trunk during exercises

Keywords: electromyography exercise theraphy eccentric exercises quadriceps muscle activity
magnifying nbi endoscopy for gastric condition

Conditions: Gastritis H Pylori

Summary: recently, the improved resolution with standard endoscopy allows the close observation of highly inflamed gastric mucosa without a magnifying view. in a previous study, the investigators established the endoscopic classification of h. pylori-infected stomach by non-magnifying standard endoscopy. one normal rac pattern and three types of abnormal patterns were observed. overall diagnostic accuracy for predicting h. pylori-infection was 91.6%. however, there is no comparison study predicting h. pylori-infection and precancerous gastric lesions between standard and magnifying endoscopy.

the investigators aimed to evaluate the diagnostic efficacies of non-magnifying standard endoscopy for predicting h. pylori-infection status and precancerous gastric conditions, compared to magnifying nbi endoscopy

Eligibility criteria:
inclusion criteria: * gastroscopy can be performed * h. pylori test and pathological analysis can be performed exclusion criteria: * age \ 70 years * anemia (serum hemoglobin level \< 10 g/dl) * severe systemic disease * advanced chronic liver disease * use of certain medications, including proton pump inhibitors, h2- receptor antagonists, or antibiotics * history of h. pylori eradication * history of gastric surgery * recent history of upper gastrointestinal bleeding
iphone app compared to standard rr-measurement

Conditions: Hypertension; Blood Pressure

Summary: in this trial we compare a new application (app) running on an iphone (apple inc., model 4s) to determine systolic blood pressure (rr) and compare it to conventional oscillometric measurements using an omron hbp-1300-e pro device. we will include 1000 participants and perform seven repetitive blood pressure measurements (3 iphone, 4 omron) in each person. primary parameter will be the absolute difference (delta) between the correlating blood pressure measurements in mmhg.

participants will be asked for consent at the university hospital basel at random based on availability. recruitment is not limited to patients. after consenting patients will accompanied to a rr-measurement unit, positioned in a chair and kept at rest for 4 minutes. then 7 blood pressure measurements at the same arm will be performed (cuff/iphone/cuff/iphone/cuff/iphone/cuff). the cuff measurement results will be documented in the source documents (mmhg) and transferred to a trial database. the iphone data will be transferred with patient id to "preventicus" for calculation of the systolic blood pressure values (mmhg) based on the pulse waves recorded by transillumination of the index fingers of the participants. "preventicus" will have no access to the cuff-measurement data. then this data will be retransferred to the trial site and merged with help of the patient id. absolute and relative differences of the measured (omron) and calculated (iphone) systolic blood pressure values (mmhg) for will be calculated and published. a subgroup of 40 participants will be evaluated in a highly standardized fashion according the esh (european society hypertension) guidelines for validation studies. these data will then be published separately for validation purposes.

Eligibility criteria:
inclusion criteria: * able to give informed consent * in sinus rhythm * no anatomical limitation to take blood pressure exclusion criteria: * atrial fibrillation * dialysis shunt
a study to evaluate the efficacy and safety of intravitreal ksi-301 in non-proliferative diabetic retinopathy (npdr)

Conditions: Non-proliferative Diabetic Retinopathy

Summary: this phase 3 study will evaluate the efficacy and safety of ksi-301 in participants with moderately severe to severe non-proliferative diabetic retinopathy (npdr).

this is a phase 3, prospective, randomized, double-masked, sham-controlled, two-arm, multicenter study evaluating the efficacy and safety of repeated intravitreal dosing of ksi-301 5 mg in participants with moderately severe to severe non-proliferative diabetic retinopathy (npdr). the primary endpoint will be assessed at week 48; additional secondary endpoints for efficacy will be assessed at week 48, week 96 and if applicable, over time.

Eligibility criteria:
inclusion criteria: * signed informed consent prior to participation in the study. * type 1 or 2 diabetes mellitus * moderately severe to severe npdr in the study eye (drss levels 47 and 53 as determined by the reading center), in which pan-retinal photocoagulation (prp) can be safely deferred for at least 6 months per the investigator. * bcva etdrs letter score in the study eye of ≥69 letters (approximate snellen equivalent of 20/40 or better) * hba1c of ≤12%. * other protocol-specified inclusion criteria may apply. exclusion criteria: * presence of center-involved dme in the study eye * prior prp in the study eye. * current anterior segment neovascularization (asnv), vitreous hemorrhage, or tractional retinal detachment in the study eye. * prior intravitreal anti-vegf treatment in the study eye for dr or dme. * prior intravitreal or periocular steroid in the study eye for dr or dme. * prior use of an investigational intravitreal treatment for dr or dme in the study eye. * any history or evidence of a concurrent ocular condition present in the study eye, that in the opinion of the investigator could require either medical or surgical intervention or alter visual acuity during the study * active or suspected ocular or periocular infection or inflammation. * women who are pregnant or lactating or intending to become pregnant during the study. * history of a medical condition that, in the judgment of the investigator, would preclude scheduled study visits, completion of the study, or a safe administration of investigational product. * recent history (within the 6 months prior to screening) of myocardial infarction, stroke, transient ischemic attack, acute congestive heart failure or any acute coronary event. * uncontrolled blood pressure defined as a systolic value ≥ 180 mmhg or diastolic value ≥ 100 mmhg while at rest. * other protocol-specified exclusion criteria may apply.

Keywords: non-proliferative diabetic retinopathy diabetic retinopathy npdr ksi-301 vegf anti-vegf vascular endothelial growth factor antibody biopolymer conjugate retinal degeneration retinal diseases eye diseases retinopathy vision disorders kodiak
nucleotide protein -3 in epileptic children

Conditions: Epilepsy in Children

Summary: epilepsy is one of common serious neurological malfunction, characterized by recurrent unprovoked seizures. it always accompanied with multitude of complications as cognitive, behavioral, and psychiatric disorders. experimental studies and clinical evidence obtained in animal models of epilepsy and human brain specimen from various drug-resistant forms of epilepsy show the activation of the innate and adaptive immunity mechanisms and the induction of the associated inflammatory processes in the epileptogenic foci.

epilepsy affects approximately 1% of the world population. lifetime prevalence of childhood and adolescence epilepsy (children \<18 years) in upper egypt was 9.7/1000, with higher prevalence among children \<12 years (10.8/1000). there is a clear cause for epilepsy in only a minority of the cases, while in up to70% of all case of epilepsy in adults and children, no cause can be discovered. some of the main causes of epilepsy include: low oxygen during birth, head injuries that occur during birth or from accidents during youth or adulthood, brain tumors, infections such as meningitis or encephalitis, stroke or any other type of damage to the brain. a role of inflammatory molecules in the generation of seizures had been first investigated when selected anti-inflammatory treatments, in particular, steroids, immuno-globulins, and adrenocorticotropic hormone (acth), were shown to control seizures in pediatric epilepsies refractory to conventional anticonvulsive drugs. in addition, specific epileptic disorders have been associated with the presence of neuronal antigen-directed antibodies in plasma or cerebrospinal fluid (csf). a nucleotide-binding oligomerization domains (nods) are cytosolic proteins that include key regulators of apoptosis and pathogen resistance in mammals and plants. a large number of nods contain leucine-rich repeats (lrrs), hence referred to as nod-lrr proteins. the nlrp3 gene provides instructions for making a protein called cryopyrin. cryopyrin is a member of a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (nlr) proteins. nlr family have two common features: the first is a nucleotide-binding oligomerization domain which is bound by ribonucleotide-phosphates (rntp) and is important for self-oligomerization. the second is a c-terminal leucine-rich repeat, which serves as a ligand-recognition domain for other receptors (e.g. toll like receptor (tlr)) or microbial ligands, while nlrp3 has been identified in microglial cells.

Eligibility criteria:
inclusion criteria: * epileptic children in assiut university hospital, pediatric department, neurology unit. exclusion criteria: * children with other chronic disease such as liver, kidney or heart disease * patient who have apparent infection

Keywords: epilepsy children nlrp3 interleukin b1 nuclear factor-kappa b
gait modification treatments for knee pathology

Conditions: Knee Injuries; Knee Osteoarthritis

Summary: the objective of this study is complete a longitudinal cross-over clinical study to investigate the effect of treatments for knee pathology, including cutaneous stimulation (skin vibration and soft knee brace), on locomotion tasks (i.e. walking, jogging, stair ascending and descending), muscle function, and pain/function.


Eligibility criteria:
inclusion criteria: * age 18-80 * ambulatory * symptomatic knee pain ≥ 3/10 on most of the past 30 days * prior acl injury/surgery, meniscus injury/surgery, and/or physician-diagnosed medial compartment knee osteoarthritis (kl grade 1-3) * agreement and ability to use provided interventions during the study period (suggested cumulative wear time during walking of 1-2 hr/day) * committed to not starting any new therapies for knee condition during the trial, other than rescue pain medication. exclusion criteria: * use of walking aid (e.g. cane, crutch, walker, or wheelchair) * bmi ≥ 35 kg/m2 * injection in the affected knee during the previous three months * known neuropathy due to diabetes or other causes * inability to provide informed consent

Keywords: knee pathology
pre-hospital ventilation clinical study

Conditions: Altered Mental Status; Sepsis; Heart Failure; Hemorrhage; Respiratory Distress Syndrome, Adult; Cardiac Arrest

Summary: this study will collect and characterize ventilator use during patient care with a zoll 731 series ventilator in a pre-hospital setting.

this is a prospective, observational study. zoll will develop a methodology to collect and transfer ventilator data from the device to zoll to allow for a characterization of ventilator use in the pre-hospital setting. this knowledge and experience will subsequently be used to inform development of a mechanism to allow for automatic data collection and transmission from zoll ventilators to a central data repository. these data will be used to provide feedback, reporting, and benchmarking to individual agencies and departments on their ventilator use as well as aggregate use data from all ventilators to allow for comparisons. enrollment in this study is expected to take approximately 24 months. no patient outcome data will be collected.participants are enrolled once data have been downloaded from the ventilator via rescuenet® ventreview software. participants will not be followed after the assessment of study objectives.

Eligibility criteria:
inclusion criteria: * candidates for this study must meet all of the following inclusion criteria: 1. ventilated using zoll 731 series ventilator with release 5 (or greater) software 2. data recorded in ventilator data file exclusion criteria: * none

Keywords: ventilation pre-hospital
individual and group exercise program for industrial workers with cans: randomized controlled trial

Conditions: Musculoskeletal Disorder of the Neck

Summary: this study is double-blinded rct, whose aim is to assess if an individual exercise program is more effective to reduce complaints in neck, shoulders and arms that an group exercise program, in industrial workers. the participants will be randomly allocated to receive 12 treatment sessions of individual exercise training (iet) or in group exercise training (get). sessions will last 30 minutes and will be held twice a week for 12 weeks. participants will also be encouraged to continue the use of medicines and other health care.

this study is double-blinded rct. participants will be recruited from employees of the companies and industries located in the south of bahia, brazil or by referral from general practitioners, orthopedists, this study is single-blinded rct, whose aim is to assess the efficacy of an individual exercise program for employees with complaints in neck, shoulders and arms. participants will be recruited from employees of the companies and industries located in brazil or by referral from general practitioners, orthopedists, neurologists or physiatrists. the sample of 100 participants was determined by a sample size calculation designed to detect a clinically important difference of 10 points in the dash questionnaire (estimated standard deviation = 16,65 points). the following specifications will be considered: α=0.05, statistical power of 80% and follow-up loss of up to 15%. the participants will be randomly allocated to receive 12 treatment sessions of individual exercise training (iet) or in group exercise training (get). sessions will last 30 minutes and will be held twice a week for 12 weeks. participants will also be encouraged to continue the use of medicines and other health care.

Eligibility criteria:
inclusion criteria: * clinical diagnose of nontraumatic complaints of the arm, neck or shoulder with minimum intensity of 4 points on the visual analogue pain scale1, for at least 6 weeks2. exclusion criteria: * participants with contraindication to physical exercise * participants who had been diagnosed with cervical disc hernia; shoulder instability; fractures; frozen shoulder; systemic diseases such as rheumatoid arthritis or diabetes; neurological diseases or other severe medical or psychiatric disorders

Keywords: musculoskeletal symptom industrial workers physical-activity program resistance training randomized controlled trial
use of placental alpha microglobulin-1(pamg-1) to diagnose premature rupture of membranes in pregnant women

Conditions: Preterm Labor; Preterm Birth

Summary: the study is to evaluate the accuracy of a test device called "pamg-1" to see if a pregnant women has ruptured membranes in comparison to standardly used testing methods.

the study is to evaluate the accuracy of the pamg-1 immunoassay in comparison to standard diagnostic methods for premature preterm rupture of membranes including the sterile speculum exam and the amniodye test as the gold standard. the procedure includes the insertion of a swab into the subject's vaginal vault without a speculum for one minute. once the swab is obtained, the treating physician will place the swab in a solvent vial for one minute. a developing strip is then placed in a vial and allowed to develop for five minutes. the results are read from the developing strip. processing of this swab will be performed without further involvement of the study participant. the insertion of the swab is a one time procedure and is the only addition to any standard of care that would applied to the patient during their clinical evaluation at that time. given the study group and both pregnant and non-pregnant controls, standard of care procedures will include a wide variety of obstetrical and/or gynecological (ob/gyn) procedures including but not limited to a vaginal exams, sterile speculum exams (including pap smears), biopsies, and amniocentesis. the swab for the pamg-1 immunoassay will be performed after other evaluations are performed. medical records of the subject and (if applicable) her newborn infant will be reviewed for data pertaining to the study, including, but not limited to, maternal and fetal outcomes at the time of enrollment and after delivery and history of the present illness requiring an ob/gyn evaluation. the study participants will not be asked to do anything in addition to what is expected for the swab and their clinical visit. the pamg-1 immunoassay will be obtained during the subjects regularly scheduled clinic appointment or hospital visit. no follow appointments will be needed.

Eligibility criteria:
inclusion criteria: * women 18 to 50 years of age * being seen at the university of iowa women's healthcare clinic exclusion criteria: * men