Kornimate/medical-research-clean huggingface dataset:
study of blood samples from patients with ewing sarcoma and their relatives

Conditions: Sarcoma

Summary: rationale: studying samples of blood in the laboratory from patients with cancer and their relatives may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is looking at blood samples collected from patients with ewing sarcoma and their relatives.

objectives: * to identify and characterize a genetic susceptibility factor to ewing's sarcoma by performing a genome-wide association study with as many as possible ewing sarcoma patients. outline: this is a multicenter study. blood samples are collected from patients and their relatives. blood dna samples are analyzed for susceptibility genes of ewing sarcoma.

Eligibility criteria:
disease characteristics: * patients with ewing sarcoma * relatives of ewing sarcoma patients patient characteristics: * patients with a fusion genes specific of ewing sarcoma prior concurrent therapy: * not applicable

Keywords: ewing sarcoma ewing sarcoma/peripheral primitive neuroectodermal tumor (pnet)
diagnoses associated with persistent elevation of creatine kinase

Conditions: Creatine Kinase; Muscular Diseases

Summary: serum creatinine kinase (ck) level varies with age, gender, race and physical activity. for these reasons there is no normal serum ck level. many pathological situations cause hyperckemia, such as neuromuscular disorders (muscular dystrophy, inflammatory myositis, mitochondrial myopathy) and multiple systemic causes. the diagnostic approach to pauci or asymtomatic hyperckemia can therefore be difficult and lead to multiple, and sometimes invasive tests, such as muscle biopsy. this study aims to describe the diagnoses associated with persistent elevation of serum creatine kinase and to precise the role of the muscule biopsy.


Eligibility criteria:
inclusion criteria: * patients hospitalised in a ward of internal medicin * having a persistent elevation of serum creatine kinase \>3 times the upper normal laboratory value, repeated for 2 times exclusion criteria: * known neuro-muscular disease causing elevation of creatine kinase * evident post-traumatic cause responsible for the elevation of creatine kinase * incomplete medical records

Keywords: creatine kinase
safety and effectiveness of gamma capsulotomy in intractable ocd

Conditions: Obsessive Compulsive Disorder

Summary: a research study of the effectiveness and safety of gamma knife ventral capsulotomy in patients with severe intractable obsessive-compulsive disorder (ocd).


Eligibility criteria:
inclusion criteria: 1. ocd, diagnosed by structured clinical interview for dsm-iv (scid-iv), judged of disabling severity with a yale-brown obsessive compulsive scale (ybocs) score of at least 30 and a social and occupational functioning assessment scale (sofas) score of 45 or less. 2. persistence of severe symptoms and impairment for five or more years despite: 1. at least three adequate (≥3 months at the maximum tolerated dose) serotonin transporter inhibitor trials (fluoxetine, sertraline, fluvoxamine, paroxetine, citalopram, escitalopram, or clomipramine) alone or in combination with, 2. adequate behavior therapy (≥20 sessions of expert exposure and response prevention), and 3. augmentation of one of the selective sris with clomipramine, a neuroleptic, and clonazepam. 3. age between 18 and 65 years. 4. able to understand and comply with instructions. 5. able to give fully informed, written consent in the judgment of the consent monitor. 6. either drug free or on a stable drug regimen for at least 6 weeks. 7. good general health. 8. a family member or significant other is available and willing to communicate with the research team if the patient's clinical status worsens. 9. the local referring psychiatrist is willing to provide ongoing care. exclusion criteria: 1. current or past psychotic disorder. 2. full-scale iq below 85. 3. a clinical history of bipolar mood disorder. 4. any current clinically significant neurological disorder or medical illness affecting brain function, other than tic disorders or tourette syndrome. 5. any clinically significant abnormality on preoperative magnetic resonance imaging (mri). 6. inability to undergo presurgical mri (cardiac pacemaker, pregnancy, metal in body, severe claustrophobia. 7. current or unstably remitted substance abuse, dependence, or a positive urine toxicology screen. 8. pregnancy and women of childbearing age not using effective contraception. 9. unable to adhere to operational and administrative study requirements (in the investigators' judgment). 10. clinical history of severe personality disorder. 11. imminent risk of suicide (in the investigators' judgment).
the effect of psoriatic arthritis on the functions of the hand

Conditions: Psoriatic Arthropathy Hand; Psoriatic Arthritis

Summary: this study was planned to evaluate the effect of psoriatic arthritis on the strength, proprioception, skill, coordination, and functional condition of the hand and to determine the correlate disease activity with these parameters.

psoriatic arthritis (psa) is a chronic, progressive, inflammatory arthritis that occurs as a condition associated with patients with psoriasis and may result in permanent joint damage and an increased risk of mortality. synovial membrane inflammation characterized by increased vascularization and immune cell infiltration is an important feature of psoriatic arthritis. this inflamed synovial microenvironment leads to the formation of synovial pannus, entheseal inflammation, and joint damage. although psa is generally thought of as a benign arthropathy, structural damage has been shown with the progression of the disease, along with joint inflammation.as a result of the researches, it has been stated that tissue biomechanical stress and microtraumas that lead to the activation of abnormal natural immune responses in psoriatic arthritis can trigger joint inflammation. in parallel, inflammation is expected to be more common in peripheral joints, which are known to be more exposed to microtrauma. studies have reported that hand joint involvement is frequently seen in patients with psa and is an important cause of loss of function and that erosions in hand joints are associated with statistically significant loss of hand strength. theoretically, either the mechanical effect of the fluid in the acute joint effusion or the components of the inflammatory fluid and the changing capsular compliance after chronic effusion and has been reported that problems may occur in proprioception due to causes such as pain, trauma, and fatigue. however, pain, decreased joint rom and grip strength, muscle weakness, and hand deformities can affect hand fine hand skills and function. the hypothesis of this study is that supporting the clinical condition of the participants with parameters related to general hand function will be effective in predicting disease progression and disability. accordingly, the aim of the researchers is to evaluate the effect of psa on the grip and pinch strength of the hand, proprioception, skill, coordination and functional status, and to determine the relationship of disease activity with these parameters.

Eligibility criteria:
inclusion criteria: * individuals between the ages of 18-65 exclusion criteria: * neurological diseases that caused sequelae at hand, upper extremity surgeries, neuropathies, traumas, and history of nerve damage * psychiatric disorders, * reluctance to continue evaluation

Keywords: psoriatic arthritis pathogenesis disease activity hand
immunoscore in rectal cancer

Conditions: Cancer of the Rectum; Neoplasms, Rectal; Rectal Cancer; Rectal Tumors; Rectal Adenocarcinoma

Summary: this is an observational study of tumor samples and mri imaging in patients with colorectal cancers. a tumor sample, mri scans, and treatment outcome data will be used for research purposes to see if it is possible to predict patients' response to treatment.

the quality of the immune environment in colorectal cancer biopsy samples correlates with disease-free survival and overall survival more so than current staging conventions. this study will use a scoring system called 'immunoscore' to characterize the immune enviroment. researchers hypothesize that the immunoscore will correlate with outcomes of colorectal patients treated with neoadjuvant chemoradiation.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of a rectal mass suspicious for or known to be an adenocarcinoma of the rectum. * age \> 18 * ability to give informed consent and comply with the protocol. patients with a history of psychiatric illness must be judged able to understand fully the investigational nature of the study and the risks associated with the therapy. exclusion criteria: * history of other malignancy in the past 2 years except carcinoma in situ of the cervix or bladder, or non-melanomatous skin cancer * other medical or psychiatric conditions that in the opinion of the principal investigator would preclude safe participation in protocol.

Keywords: immunophenotype immunoscore mri rna later
intensified acute kidney disease care to reduce chronic kidney disease

Conditions: Acute Kidney Injury; Renal Insufficiency, Chronic; Acute Kidney Disease; Decision Support Systems, Clinical

Summary: strategies to stop aki-akd-ckd continuum - policy is one of the collaborative projects, strategies to stop aki-akd-ckd continuum, epidemiology, immunology, repair, artificial intelligence, and policy (eirap). it is aimed to study effective interventional strategies that lower the incidence of ckd among patients with akd. the intensified akd care to reduce ckd (isacc trial) is a prospective, open-labeled, randomized controlled trial is designed to evaluate the efficacy of multidisciplinary team care (mdt) model and acute kidney disease (akd) clinic visits

acute kidney disease (akd), defined as the ongoing renal function impairment between 7 days and 90 days following aki, has been proposed as a window of intervention to prevent the occurrence of ckd. however, the effective therapeutic strategies of akd care remain to be developed. we intend to conduct a prospective, randomized, open-label, behavioral interventional trial to validate the efficacy of multidisciplinary team (mdt) care model which aims to improve akd care and to reduce de novo ckd incidence.

Eligibility criteria:
inclusion criteria: * age ≥ 20 yrs * severe akd: stage 2, stage 3 and dialysis-requiring akd (akd-d) exclusion criteria: * pregnancy

Keywords: acute kidney injury acute kidney disease chronic kidney disease aki akd ckd decision support systems, clinical cds
clinical and radiographic evaluation of resin endocrown as long term interim restoration versus stainless steel crown for endodontically treated first permanent molar in children: randomized controlled pilot study.

Conditions: Dental Caries in Children

Summary: management of endodontically treated first permanent molar with deep dental caries is one of the challenging procedure that the operator face. using resin endocrown or stainless steel crown restoration to make comparison which one is more successful in children.

diagnostic procedure: diagnosis of the cases will be performed according to guidelines of aapd 2017 for treatment of irreversible pulpitis and necrotic pulp therapy in mandibular first permanent molar . preoperative periapical radiograph will be taken intra operative procedure: local anaesthesia administration using articaine 4% with epinephrine 1:100000. rubber dam application and access cavity preparation will be established using a sterile bur. root canal treatment will be done and then the dental orifices of the pulp chamber will be sealed using a flowable composite. the immediate postoperative radiograph will be done to reveal optimal root canal treatment. in the intervention group: the preparation of cavity design will be as following: preparation of occlusal surface will be done with wheel stone to create 2 mm occlusal clearance; the occlusal surface will be prepared flat to create a butt-joint. the junction between the occlusal and mesial cavity will be rounded to produce cervical side walk. • divergence of the inner cavity walls will be obtained using a tapered stone with a rounded end (tr- dia bur mani). impression will be taken for the prepared tooth structure using addition silicone material (elite hd zermach, italy), stone model will be poured for fabrication of endocrown to allow for blockage of any undercuts in the pulp chamber cavity. finished final endocrown restoration will be cemented in place using self-adhesive universal dual cured resin cement (rely x unicem, 3m, usa). in the control group tooth preparation will be made as follow: by reducing mesial, distal and occlusal surface. the crown margin will be placed just apically to the gingival margin and carefully adjusted to give an accurate fit in this region. the crown will be cemented with glass ionomer cement. follow up: clinical and evaluation will be performed at 1 st week, 3, 6, 9 and 12 months. radiograph evaluation will be performed at, 1 st week, 6 and 12 months

Eligibility criteria:
inclusion criteria: * cooperative children in age range from 10 to 13 years * mandibular first permanent molar indicated for root canal treatment with closed apex. * presence of at least two to three sound walls of tooth. * absence of internal or external pathologic root resorption. * normal occlusion without any para-functional habits. * parent or guardian agree for participant in the study exclusion criteria: * excessive mobility. * children with underlying systemic disease. * children with special health care needs. * poor oral hygiene.
safety and intraocular pressure (iop)-lowering efficacy of al-39256 in patients with open-angle glaucoma or ocular hypertension

Conditions: Open-Angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to evaluate the safety and intraocular pressure (iop)-lowering efficacy of al-39256 in patients with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * diagnosed with open-angle glaucoma or ocular hypertension. * other protocol-defined inclusion criteria may apply. exclusion criteria: * females of childbearing potential. * other protocol-defined exclusion criteria may apply.

Keywords: open angle glaucoma ocular hypertension
comparative effectiveness and safety of three protocols usin li-eswt for erectile dysfunction

Conditions: Erectile Dysfunction

Summary: the patients with primary erectile dysfunction (iief-ef \<26 points), will be randomly assigned to three shockwave treatment protocols: protocol 1 six sessions, one per week; protocol 2, six initial sessions, one per week, followed by monthly maintenance sessions (every 4 weeks) for five months; protocol 3, six monthly sessions. the ehs and iief-ef scores will be compared as well as the possible adverse events from the therapy upon beginning and completing the treatment and at the 3-month and 6-month follow-ups. self-esteem and quality of life will also be evaluated using the sear scale.


Eligibility criteria:
inclusion criteria: * men over 18 years of age * presence of ed for more than 3 months in over 50% of sexual intercourses. * baseline ed domain score under 26 on the iief-15 ef domain. * patient agrees to participate in the trial by providing signed informed consent. exclusion criteria: * ehs score of 4. * patients with an inr over 3. * patients with sickle-cell anemia. * patients with clinical suspicion of hypogonadism (ams over 36). * endocrine diseases that present with ed, such as acromegaly, gigantism, addison's disease, hyperprolactinemia, androgen deficiency. * active vesicular, prostrate or colon cancer. * radical prostatectomy or other radical pelvic surgery. * history of pelvic radiation therapy. * patients with ed of psychological origin. * spinal cord injury or other neurological diseases associated with ed. * anatomical penile dysfunction, penile implant. * patients with active infections or lesions on the penis or pubic area. * patients with ed secondary to drug therapy (antiandrogen therapy, alpha blockers for bph, use of corticosteroids, medication for parkinson's disease, antipsychotics). * abuse of psychoactive substances.
evaluating the efficacy of ragweed-spire following exposure to ragweed allergen in an environmental exposure chamber

Conditions: Seasonal Allergic Rhinitis

Summary: the purpose of this study is to determine whether ragweed-spire is safe and effective at reducing allergy symptoms in people who suffer from allergy to ragweed pollen


Eligibility criteria:
inclusion criteria: * male or female, aged 18-65 years. * reliable history consistent with moderate to severe rhinoconjunctivitis on exposure to ragweed for at least the previous two seasons. * minimum qualifying rhinoconjunctivitis symptom scores * ragweed-specific immunoglobulin e (ige) \> 0.70 ku/l. exclusion criteria: * subjects with a history of ragweed pollen induced asthma * a history of anaphylaxis to ragweed allergen. * fev1 \< 80 % of predicted. * subjects who cannot tolerate baseline challenge in the eec. * subjects for whom administration of epinephrine is contraindicated (e.g. subjects with acute or chronic symptomatic coronary heart disease or severe hypertension). * history of immunopathological diseases (e.g. multiple sclerosis) that in the opinion of the investigator or the sponsor could interfere with the results obtained from the study. * a history of severe drug allergy, severe angioedema or anaphylactic reaction to food. * a history of any significant disease or disorder (e.g. cardiovascular, pulmonary, gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, neoplastic/malignant, psychiatric, major physical impairment)

Keywords: rhinoconjunctivitis rhinitis seasonal ragweed allergy
serum resistin level following non-surgical periodontal therapy in diabetic patients with chronic periodontitis

Conditions: Type2 Diabetes

Summary: non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.

background: resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. the aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis. methods: forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. pocket depth, clinical attachment level, plaque index, gingival index, serum resistin and high sensitivity c-reactive protein assay were recorded for both groups before and after treatment, while hba1c was recorded for the diabetic group.

Eligibility criteria:
inclusion criteria: * diagnosed with moderate to severe chronic periodontitis. * presence of a minimum of 15 natural teeth * presence of at least four teeth with one or more sites with probing pocket depth (ppd) ≥5mm and clinical attachment level (cal) ≥4mm * agreement to participate in the study and sign a written informed consent exclusion criteria: * patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation * a history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months * pregnancy or use of contraceptives or any medication related to diabetes * former or current smokers ˂ 5 years.
nad+ oral supplement pilot intervention in adult females

Conditions: Cognitive Change; Inflammation; Neurodegenerative Diseases

Summary: the goal of this clinical trial is to learn if nicotinamide adenine dinucleotide (nad+) can influence cognition and biomarkers in healthy, cognitively intact women who identify as latina and are between the ages of 40-80. the main questions it aims to answer are: will executive function change in response to nad+? will inflammatory markers and serum indicators of neurodegeneration change in response to nad+? researchers will compare individuals receiving the nad+ to see if the results differ from those receiving the placebo. participants will: complete an online questionnaire, visit the lab for computerized cognitive testing and a blood draw, take nad+ or a placebo every day for 4 weeks, visit the lab for computerized cognitive testing and a blood draw


Eligibility criteria:
inclusion criteria: * identify as latina, have three or more adverse childhood experiences, and a bmi of 18.5 or above exclusion criteria: * those who are taking hormone medication, pregnant or breastfeeding
lanadelumab for treatment of covid-19 disease

Conditions: COVID-19

Summary: so far little is very few drugs have demonstrated positive results for treatment of covid19. recently the researchers have shown that the use of icatibant in covid-19 results in a potent decrease in oxygen use. yet the effect of the three dosages as according to the label dose was insufficient to maintain the clinical improvement in a small group of patients. the researchers argue that with the use of lanadelumab a more lasting effect can be reached due to its longer half life.


Eligibility criteria:
inclusion criteria: * patient is sars-cov2 positive (pcr) * without oxygen a saturation below 90% * at least 3l/min oxygen dependent * patient is 16 years and older exclusion criteria: * has previously participated in this study * acute myocardial or cerebral ischemic event at time of enrolment * receiving ace or arb inhibitor or comparable drugs that is specified as an intervention in this domain as a usual medication prior to this hospitalization will exclude a patient from receiving that agent * a baseline alanine aminotransferase or an aspartate aminotransferase that is more than five times the upper limit of normal * patient is known hypersensitive to full human monoclonal antibodies * patient is pregnant or breast feeding
distribution of pulmonary ventilation in lateral decubitus of healthy adults under non-invasive mechanical ventilation

Conditions: Noninvasive Ventilation; Patient Positioning

Summary: the aim was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different continuous positive airway pressure levels (0, 5, 10 cm η2ο) in healthy subjects.

in lateral decubitus, the largest percentage of pulmonary ventilation of non-sedated subjects is distributed mainly in the dependent lung. the aim it was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different continuous positive airway pressure levels (0, 5, 10 cm η2ο) in healthy subjects. the volunteers were noninvasively ventilated in both lateral positions and supine positions at the beginning and end of the process. it is concluded that implementing non-invasive ventilation in the lateral body position resulted in increased ventilation of the dependent lung. in contrast, the respective ventilation of the non-dependent lung was further decreased.

Eligibility criteria:
inclusion criteria: • healthy volunteers exclusion criteria: * chronic respiratory disease * bmi\>40 * smoking history

Keywords: impedance tomography distribution of ventilation lateral decubitus noninvasive ventilation