Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of gsms-tace combined with surgical resection in treatment of huge hepatocellular carcinoma (hcc) (≥10cm)

Conditions: Huge Hepatocellular Carcinoma (HCC) (≥10cm)

Summary: a single center, open, randomized controlled trial evaluating the safety and efficacy of gsms-tace combined with surgical resection in treatment of huge hepatocellular carcinoma (hcc) (≥10cm).


Eligibility criteria:
inclusion criteria: 1. confirmed imaging and pathological diagnosis of hcc, or diagnosed for the first time according to the guidelines for diagnosis and treatment of primary liver cancer in china (2019 edition). 2. barcelona clinic liver cancer (bclc) stage a or b. 3. remnant liver volume and liver function reserve are suitable for surgical resection. 4. main lesion diameter ≥10cm. 5. number of hcc lesions ≤5 and all located on one liver lobe. 6. liver function child-pugh class a 7. ecog performance status 0-1 8. life expectancy ≥ 6 months 9. hcc is diagnosed for the first time. 10. age 18 to 75 years 11. able to sign and provide written informed consent. exclusion criteria: 1. severe active infection \>grade 2 (except for hepatitis b and c infection). 2. liver function child-pugh class c. 3. bclc stage c. 4. patients with unresectable hcc. 5. platelet \<60×109/l. 6. concomitant malignant tumors in other organs. 7. patient with severe cardiac, lung or kidney disease, or severe diabetes. 8. pregnant or breast-feeding woman. 9. patients with severe neuropathy and unable to report therapeutic effects. 10. patients with severe atherosclerosis. 11. patients with aids. 12. severe hemorrhage of digestive tract within the 4 weeks prior to enrolment. 13. severe thrombogenesis or embolic event within the 6 months prior to enrolment. 14. currently enrolled or going to enroll in any other clinical trials. 15. subject is not suitable to participate in the study as judged by investigator (poor patient compliance，inability to follow up).
observational study of the structural-functional connectome in patients with epilepsy

Conditions: Epilepsy

Summary: over the past decade, the concept of the brain as a complex network has extremely influenced the way regarding how the latter is studied (bartolomei et al., 2017). the structure of both structural and functional networks within the brain has been related to optimal brain functioning (duma et al., 2022). this evolution of methods and approaches of investigation has directly impacted the study of epilepsy. an early conception of focal epilepsy was that it was related to the activity of the epileptogenic zone, which was identified as the generative element of seizures. however, what was previously considered focal was found to be network alterations at various levels, thus moving from the epileptogenic zone to the concept of the epileptogenic network. alterations in both the structural and functional network, compared with a healthy control population, have been identified in various forms of epilepsy from focal to idiopathic generalized epilepsy (lariviere et al., 2022, zhang et al., 2009). often the identification and removal of the epileptogenic network, turns out to be the elective therapy in drug-resistant focal epilepsies. the process of diagnosing and defining the epileptogenic network is still debated today. one of the most widely used methods is the implantation of intracranial electrodes for electroencephalographic recording of seizures (bartolomei et al., 2017). this methodology carries with it several, albeit controlled, risks to the patient. new noninvasive approaches are being developed seeking to integrate information from structural neuroimaging and cortical electrical activity measured by high-density electroencephalography with external electrodes (duma et al., 2021). these new approaches also include simulative approaches that exploit individualized information such as cortex geometry and patient-specific white matter connections (courtiol et al. 2020). thus, starting from a simple structural and diffusion mri, which is done in routine clinical examinations, multiple localizing hypotheses of the epileptogenic network can be tested using simulative models and then compared with the real eeg signal as validation. of great relevance is also to understand how the structural-functional connectome relates to cognitive function in patients with epilepsy, who have a high probability of presenting impaired functioning in one or more cognitive domains.


Eligibility criteria:
inclusion criteria: * a diagnosis of focal or generalized epilepsy confirmed by specialist evaluation; * at least one mri scan of the brain that includes t1w * at least one recording with resting state eeg * age between 6 and 65 years at the time of the evaluation of the present study; * ability to take part in a neuropsychological assessment. exclusion criteria: * vascular causes or non-low grade tumors as causes of epilepsy * age different from the range 6-65 years * neuroradiologic examination not complete * absence of resting state recording * inability to take part in a neuropsychological evaluation.
the quality of life of patients with severe illnesses

Conditions: Schizophrenia; HIV Infections

Summary: lately researchers and clinicians have emphasized the health related quality of life. several reasons account for this trend. first of all, the advanced medical practices have contributed to the increased life expectancy. secondly, the pattern of diseases has shifted from high acuity to chronicity. therefore, the effectiveness of health care could not be solely evaluated by the rates of morbidity and mortality. the state of patients' quality of life has become the pivotal indicator of the effectiveness of health care interventions. on the other hand, patients' subjective perceptions of health care are crucial factors in treatment processes. therefore quality of life becomes reference in choosing health care interventions to enhance the benefits of patients. the scopes of quality of life research include the essence of quality of life, the measurements of quality of life and the relationships between quality of life and its related factors, etc. the local researchers have long put efforts in quality of life research. the results of these studies have contributed to the understandings of different patients' quality of life. however, the majority of studies have focused on specific diseases. this study propose to extend the scope of quality of life research to study patients' quality of life of two severe illnesses, i.e. hiv infections and schizophrenia. these two illnesses represent two severe physical and psychiatric illnesses. even their etiology, mechanisms, disease process, signs and symptoms, and treatments are different. however, the similarities of these two illnesses include both are severe illnesses without cure, both are stigmatized by the society. patients with these two illnesses suffer in their personal lives, social relations and quality of life. therefore the current study to further investigate and compare and contrast the essence of patients' quality of life and their related factors. the proposed study is a second year study of the two-year study - the quality of life of patients with severe illnesses (nsc93-2314-b-002-294). the first year study focused on the investigation of the quality of life of patients with hiv infections (nsc93-2314-b-002-294). the aim of this proposed study is to compare and contrast the quality of life and its related factors of patients with schizophrenia and hiv infections. the contributions of this study include the in-depth understandings of quality of life of patients with hiv infections and schizophrenia and the comparison of quality of life of different illnesses. the results serve as the foundations in future development of intervention programs to enhance patients' quality of life and cost-effectiveness analyses.


Eligibility criteria:
inclusion criteria: * people with schizophrenia * people with hiv exclusion criteria: -

Keywords: hiv
system for quantifying the functional strength of the grip and pinch movements

Conditions: Hand Injuries and Disorders

Summary: this study developed a system to quantify the functional strength of young adults without motor impairment during grip and pinch movement. making it possible to know the accuracy of the value of these strength, the range of motion performed and whether the grip force was maintained throughout the range of motion. in addition to checking the functionality, reliability and reproducibility of the system.

quantifying grip and grip movement is essential as it allows for a basis in upper limb functionality. however, when there is access, it causes changes in the hands and changes the motor in relation to the force and range of motion, or generates changes in activities of daily living. thus, a system with 5 devices, where each one the devices were prints in three-dimensional, and instrumented with force sensor for static-dynamic force analysis e potentiometer for analysis range of motion, during the execution of movements cylindrical grip, spherical grip, hook grip, pulp-pulp pinch, and pulp- side pinch in different activities of daily living. elaborated a data storage interface through matlab® software that allows recording the data of each device. for the system functionality tests, 30 volunteers were selected for both sexes, young adults between 20 and 39 years old, students of the physiotherapy and graduate courses of the university of mogi das cruzes. the tests are divided into two sessions and are repeated after 7 days of the first test

Eligibility criteria:
inclusion criteria: * only right-handed individuals, * male and female, * have preserved cognitive functions, * absence of neurological disorder * who present minimum grip strength by the jamar ® dynamometer, in the age group of 20-29 years men 45.08 ± 0.67 kg and women of 27.2 ± 0.46 kg, who present minimum grip strength by the dynamometer jamar ®, aged 30 to 39 years old men 46.05 ± 0.47 kg and women 28.0 ± 0.39 kg, using the mean minus the standard deviation. exclusion criteria: * injury to upper limbs such as amputation, recent surgery (6 months), fractures, bruising, pain and musculoskeletal disorders. * do not accept to participate in the survey.
nedaplatin versus cisplatin in treatment for nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: to compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.

this is a prospective, parallel, randomized, open labeled, phase iii, non-inferiority clinical trial to compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma patients in endemic area - nedaplatin, docetaxel and fluorouracil as induction chemotherapy regimen combined with nedaplatin as concurrent chemoradiotherapy (dnf-n) versus cisplatin, docetaxel and fluorouracil as induction chemotherapy regimen combined with cisplatin as concurrent chemoradiotherapy (dpf-p). all patients will receive radical intense modulate radiation therapy (imrt). the primary endpoint is progress free survival (pfs).

Eligibility criteria:
inclusion criteria: 1. patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including who ii or iii 2. original clinical staged as iii-iva (except t3-4n0) according to the 8th edition american joint committee on cancer staging system 3. no evidence of distant metastasis (m0) 4. age between 18-65 5. wbc≥4×10\^9/ l, platelet ≥ 100×10\^9/ l and hemoglobin ≥ 90g/l 6. with normal liver function test (tbil、alt、ast ≤ 2.5×uln) 7. with normal renal function test (creatinine ≤ 1.5×uln or ccr ≥ 60ml/min) 8. satisfactory performance status: karnofsky scale (kps) \> 70 9. patients must give signed informed consent exclusion criteria: 1. histologically confirmed keratinizing nasopharyngeal carcinoma (who i) 2. age \>65 or \< 18 years 3. treatment with palliative intent 4. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer 5. history of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes 6. history of previous radiotherapy 7. pregnancy or lactation 8. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, acute exacerbation of chronic obstructive pulmonary disease or other respiratory illness requiring admission to hospital, active hepatitis, and mental disturbance

Keywords: induction chemotherapy nedaplatin cisplatin concurrent chemoradiotherapy
evaluation of symbicort® turbuhaler® (budesonide/formoterol) in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this non-interventional study is to analyse the therapeutic effectiveness in patients with severe copd following a generally accepted 12-week treatment period with symbicort turbuhaler, which could anyhow be shortened or extended at physician's discretion.


Eligibility criteria:
inclusion criteria: * non pregnant female * copd with persistent symptoms in spite of regular bronchodilator therapy * naive or fixed combination treated patients including patients already on symbicort turbuhaler exclusion criteria: * hypersensitivity to budesonide, formoterol or inhaled lactose

Keywords: chronic obstructive pulmonary disease copd symbicort turbuhaler
contribution of residual tumour dna testing on the surgical bed

Conditions: Squamous Cell Carcinoma of the Oral Cavity

Summary: the aim of this study is to evaluate the interest of residual tumour dna research in the operating bed after squamous cell carcinoma excision.

squamous cell carcinomas of the oral cavity have a poor prognosis. the 5-year loco-regional recurrence rate is 45%. surgery remains the standard treatment. the presence of invasive or insufficient surgical margins is an important histopronostic factor. current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. the aim here is to develop a more sensitive tool by looking for the presence of residual tumour dna in the entire operating bed after squamous cell carcinoma excision

Eligibility criteria:
inclusion criteria: * signed informed consent * patient with t1 to t4 squamous cell carcinoma of the oral cavity, regardless of lymph node status (all n) m0, operable * 18 years of age or older * member or beneficiary of a social security scheme. exclusion criteria: * absence of signed informed consent * patient of protected age * psychosocial problems * not affiliated to or benefiting from a social security scheme * previous cervical irradiation * pregnant or breast-feeding women * patient unable to understand the study for any reason or to comply with the constraints of the trial (language, psychological, geographical problems, etc.).

Keywords: oral cavity squamous cell carcinoma residual tumor dna head and neck surgery
reorientation of tripped patients 4 and 5 in emergency department

Conditions: Emergency Department

Summary: the increase in emergency room visits is partly related to the growing increase in unscheduled care, paradoxically associated with a decrease in the outpatient supply in the city. the "avoidable" passing rate is estimated at 43% in the last major drees survey on hospital emergencies. emergency services have been facing this challenge for years, but there is an urgent need to rethink its organizational model with the liberal system to meet this growing demand. reorientation from the reception of emergencies is one of the avenues envisaged to face this challenge. it offers a different course from that of emergencies, provided that there are care structures equipped and adapted to unscheduled care. the hospital in saint-denis is particularly faced with these challenges given a particular social ecosystem. methodology : this single-center prospective observational study includes all adult patients sorted 4 and 5 by the reception organizing nurse, present during the survey. the reorientation is one of the solutions proposed in the context of reorganizing access to care throughout the territory, appearing as one of the major public health issues in the coming years, it is appropriate to ask the question on a local scale. particularly exposed to the problem of unscheduled care, if patients are eligible for reorientation the non-medical factors identified as limiting the reorientation are: the absence of social cover, the language barrier, the patients referred by the samu or the fire brigade or a doctor, the patients who came by ambulance (because considered in theory as in the impossibility to move or having already been the subject of a "regulation") each 4 or 5 redirected patient is included and completes a questionnaire allowing the collection of information relating to their care pathways. primary endpoint : determine the proportion of patients not eligible for reorientation on non-medical criteria via a questionnaire, and identify the distribution of factors complicating reorientation secondary endpoints : identify the needs of patients re-orientated towards city medicine via the analysis of their passage to the emergency room, the reasons for their recourse to the emergency room (reasons, means and modes of arrival) their knowledge of the health system, and their relationship to general medicine


Eligibility criteria:
inclusion criteria: * patients tripped 4 and 5 at the ioa * patients aged 18 years or older * patients presenting to the emergency room every day of the week during the day and in the evening exclusion criteria: * patients triaged 1, 2, 3 at the ioa * consulting patients for reasons requiring psychiatric advice * unaccompanied minor patients * patients brought by the police * refusal or impossibility to participate * protected adult patients
a postmarket randomized study of the treatment of superficial partial-thickness burns using two dressings

Conditions: Burns

Summary: the purpose of this research study is to compare the rate of healing, the infection or complication rate, pain perception and scarring from burn injuries using two types of burn dressings.

the purpose of this study is to evaluate awbat™ compared to biobrane® for the treatment of superficial partial-thickness burns using the patient as their own control.

Eligibility criteria:
inclusion criteria: * superficial partial thickness burns * two non-contiguous burn sites or the same approximate size/depth for comparison, or * one burn site large enough to accommodate both a 6" square awbat™ dressing and a 6 " square biobrane® dressing * burn wounds measuring \>2% - \<40% tbsa * patient age: \>1 - 70 years exclusion criteria: * ventilator dependence * pregnancy/lactation * mechanism of injury was electrical, chemical or frostbite * co-morbidity which may compromise healing * known allergy to porcine or porcine products

Keywords: burn superficial burns partial thickness burns rate of healing infection rate pain perception non adherence scarring
study on the regulatory effects of personalized innovative youtiao intervention on nutritional health

Conditions: Metabolism and Nutrition Disorder

Summary: the goal of this clinical trial is to investigate the effects of personalized innovative fritters on the nutritional health of overweight and obese individuals aged 40 to 70 years. the main questions it aims to answer are: * how does consuming personalized innovative fritters affect the nutritional health of overweight and obese individuals? * what is the mechanism underlying the impact of personalized innovative oil bars on nutritional health? participants will be randomly assigned to one of two groups: a trial group consuming personalized innovative fritters and a control group consuming traditional fritters with equal energy content. over the course of 6 months, participants will undergo two phases of intervention separated by a two-month washout period. during the intervention, participants will be assessed comprehensively for sensory ratings and nutritional health status through biological indicators, physical examinations, and other relevant measures. researchers will compare the trial group to the control group to determine if personalized innovative fritters lead to improvements in nutritional health compared to traditional fritters.

participants entered the trial with a 1-week equilibration period during which baked and fried foods were prohibited. the test group will consume personalised innovative youtiao and the control group will uniformly consume traditional youtiao of equal energy, 45 g 4 times per week for 8 weeks, during which time we will periodically measure biological indicators and collect biological samples to gain insight into the effects of the personalised innovative youtiao on the participants. after completion of the 8-week intervention, a washout phase is entered. during this phase, participants will no longer ingest the youtiao to see how they trend after stopping the intervention. participants then enter the second phase of the trial, where the intervention process described above is continued with appropriate consumption adjustments based on the initial results of the first phase of the intervention.

Eligibility criteria:
inclusion criteria: * age between 40-70 years old (women need to be menopausal); * bmi\>24 kg/m2; * consumption of fritters more than once a week. exclusion criteria: * history of diabetes mellitus, cardiovascular disease, dyslipidaemia, renal disease, - * liver disease or cancer; * surgical treatment within 3 months; * allergy/intolerance to the study food or any of its ingredients; * breastfeeding or pregnancy; * \>10% weight loss in the past 6 months; * smoking or alcohol abuse; * participation in another clinical study within the past 6 months
a study of saquinavir/ritonavir in liver-impaired patients with hiv infection.

Conditions: HIV Infections

Summary: this 2 arm study will assess the effect of moderate liver impairment on the pharmacokinetics of saquinavir and ritonavir at steady state following administration of saquinavir/ritonavir 1000mg/100mg po bid in hiv patients. saquinavir/ritonavir will be administered concomitantly with 2 to 3 active nucleoside reverse transcriptase inhibitors. the study will compare a group of hiv patients without known liver disease and a group with moderate liver disease. the anticipated time on study treatment is \<3 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, 18-65 years of age; * hiv infection; * normal liver function, or moderate liver disease (child-pugh grade b); * antiretroviral therapy naive and eligible to take antiretroviral treatment as per treatment guidelines, or treatment experienced for at least 4 weeks prior to first dosing. exclusion criteria: * severe ascites at screening, or child-pugh grade c; * acute infection or current malignancy requiring treatment; * taking any inhibitor of cyp3a4 (with the exception of anti-hiv drugs) within 14 days prior to first dosing; * taking any inducer of cyp3a4 (with the exception of anti-hiv drugs) within 4 weeks prior to pharmacokinetic evaluation (day 14 or 28); * evidence of resistance to saquinavir.

Keywords: treatment naive