diadynamic and exercises in knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: osteoarthritis represents failed repair of joint damage resulting from stresses initiated by any joint or periarticular tissue abnormality. the rate of progression varies among persons and within a knee over time. the symptoms and signs of knee osteoarthritis include pain, stiffness, reduced joint motion, and muscle weakness. long-term consequences can include reduced physical activity, deconditioning, impaired sleep, fatigue, depression, and disability.this reduction in activity to avoid pain (kinesiophobia) to evade the onset of pain, especially in the acute phase, limiting their compliance with effective rehabilitation strategies such as regular exercises. physical medicine has a wide range of analgesic anti-inflammatory and muscle stimulating treatment methods. both diadynamic and tens currents have become the most frequently implemented electrotherapeutic methods. the impact of diadynamic currents consists of analgesic effects and specific dynamics during the formation of physiological processes in tissues. they occur during the administration of the current and lasts up to a few hours after the treatment has been terminated. one of the theories explaining the analgesic effect of diadynamic currents is the gate control theory of pain by wall and melzack. recently, another theory has become very popular. it explains the analgesic effect provoked by bodies characterized as polypeptides called endorphins. electric stimulation using diadynamic currents generates an increase in the amount of endorphins in a system. although the analgesic impact of tens therapy is well known, diadynamic currents therapies have not been studied in knee osteoarthritis pain conditions. therefore, the aim of the present study was to investigate the medium-term effects of diadynamic currents combined with exercise on pain and disability in patients with osteoarthritis of the knee.

the study included patients who attended the special rehabilitation services in taboão da serra-sp, with knee osteoarthritis diagnosed by an independent rehabilitation specialist, and fulfilled the following inclusion criteria: (1) aged from 50 and 75; (2) symptomatic knee osteoarthritis for at least three months; (3) visual analogue scale12 score above 3 and (4) radiographic knee osteoarthritis (uni or bilateral) compatible with kellgren-lawrence grade two or higher. the exclusion criteria were as follows: contraindication to laser application (e.g. cancer and insulin-dependent diabetes); inability to perform the assessment or treatment; continuous use of anti-inflammatory drugs, symptomatic hip osteoarthritis and physiotherapeutic knee treatment within the last 3 months. all potentially eligible participants were contacted by telephone and those interested in participating were invited to attend a physical examination for inclusion and exclusion criterion. all participants were informed about the study and provided informed consent before participating. they were assigned by block randomization, stratified according to treatment group. an independent researcher not involved in outcome assessment was responsible for group allocation, using a computer-generated random number table. immediately after baseline assessment by the blinded assessor, the treating physiotherapist accessed the allocation schedule from a centrally located locked cabinet. patients and the physiotherapist responsible for the evaluation and physiotherapist responsible for the treatment were all unaware of the randomization results as allocation to groups was concealed. demographic and anthropometric data, the use of pain relief medications, the duration of knee pain, the knee range of motion, and a range of patient-reported outcomes were collected at baseline (before randomization) and 8 weeks from baseline by the same blinded evaluator. the primary outcomes were pain intensity measured by the numeric pain rating scale (0-10) with a minimal clinically important change set at two points and disability measured using the lequesne questionnaire, which consists of 11 questions about pain, discomfort, and function. scores range from 0 to 24 (from 'no' to 'extremely severe' dysfunction). secondary outcomes included medication intake (paracetamol) for knee pain relief, mobility and balance, range of motion, muscular strength, and activity. mobility and balance were evaluated by the timed up and go test. the timed up and go test, a measure of functional mobility, quantifies in seconds the time that the individual needs to stand up from a chair, walk 3m, turn back toward the chair and sit down again. range of motion of the knees was measured with a universal goniometer (aesculap). muscular strength was estimated at maximal isometric force for the quadriceps, using a portable dynamometer (lafayette, usa). under stabilized conditions, patients, sitting with knees flexed at 60 (measured by a goniometer), were asked to extend the legs as far as they could. three attempts were conducted, and the mean value was obtained. muscular strength was estimated at maximal isometric force for the quadriceps, using a portable dynamometer. under stabilized conditions, patients, sitting with knees flexed at 10, 60 and 90 degrees (measured by a goniometer), were asked to extend the legs as far as they could. three attempts were conducted and the mean value was obtained. physical activity was measured using the western ontario and mcmaster universities osteoarthritis questionnaire, which is self-administered and measures pain, stiff joints, and physical activity. increased scores suggest decreased activity. in this study, all patients had osteoarthritis of both knees, and in every patient both knees were treated with the allocated treatment. participants in the group i received diadynamic currents associated to exercise while the group ii received only exercises three times a week for 8 weeks following initial assessment. the group i, diadynamic currents was performed with the following parameters: application of the two-phase current and then the long-term one. each current was applied for 4 minutes on the medial and lateral sides of the knee. all patients followed the same training program (table 1). the intervention was divided into phase-1, phase-2 and phase-3 during eight weeks with three sessions a week. each session lasted 45 minutes: * 10 minutes warming-up (treadmill, ergometer bike or rowing machine); * 30 minutes 2-3 sets with phase-1, phase-2 and phase-3; * 5 minutes stretching (hamstrings, quadriceps, adductors, and gastrocmenius). participants were instructed not to use analgesic medications other than paracetamol (500 mg/day) or anti-inflammatory drugs during the study, and not to perform any other type of physical exercise in addition to the exercise performed during the study. after describing the data, the hypothesis of normality of continuous variables was tested using the shapiro-wilk test. the age, weight, height and bmi of volunteers between groups were compared using student's t-test for independent samples. to investigate the effect of the treatment on the pre and post evaluation, as well as the interaction of this effect between the groups, the general linear models with mixed design (evaluations x groups) were applied. to analyze the effects of the interactions, tukey's post hoc tests were performed considering an alpha error of 5%. all analyzes were performed using the statistical program r version 3.1.3 using the r commander graphical interface.

Eligibility criteria:
inclusion criteria: 1. aged from 50 and 75; 2. symptomatic knee osteoarthritis for at least three months; 3. visual analogue scale12 score above 3 and 4. radiographic knee osteoarthritis (uni or bilateral) compatible with kellgren-lawrence13 grade two or higher. exclusion criteria: 1. contraindication to laser application (e.g. cancer and insulin-dependent diabetes); 2. inability to perform the assessment or treatment; 3. continuous use of anti-inflammatory drugs, 4. symptomatic hip osteoarthritis 5. physiotherapeutic knee treatment within the last 3 months.

Keywords: pain electric stimulation therapy exercise therapy