Kornimate/medical-research-clean huggingface dataset:
preventing respiratory health problems in bakery employees

Conditions: Chronic Obstructive Lung Disease; Rhinitis

Summary: the study is a follow-up of investigations done in the years 1999-2002 in bakery employees. the main purposes are to look at the associations between flour dust exposure and respiratory disease, and to find out the best ways to reduce the flour dust levels in the working environment.

background and methods: supported by the the confederation of norwegian enterprise (cnbi) working environment fund a follow-up study of 184 bakery workers in 5 bakeries was done in 2012, appr. 10 years after a similar study in 1999-2002. in addition a cross-sectional study in 2 other bakeries (one 'bread-factory', and a traditional bakery with three small bake shops) was added. altogether 253 participants, among them 61 former bakery workers, were investigated with use of questionnaires, allergy-testing (skin prick testing, and blood samples for specific ige and total ige), spirometry with reversibility testing, exhaled no-measurement, and nasal measurements. as in 1999-2002 an extensive exposure assessment was performed including personal samples of total dust (gelman), inhalable dust (pas6), as well as direct reading measurements of dust (dust track). a job exposure matrix (jem) was created enabling each participant to be assigned an exposure value of probable mean daily flour-dust exposure based on work-tasks and bakery. aim of study: * follow-up of the participants in the 1999-2002 study, both still active bakery workers and former workers, on health-status focusing on respiratory disease, sensitization to common and occupational allergens, level of sick-leave and reasons for quitting as a baker. * inclusion of 'new' bakery workers into the cohort as a cross-sectional study, and to compare health-status in two cross-sectional cohorts. * to assess personal exposure to flour-dust among workers in 7 bakeries, as part of the cross-sectional study described above. * to identify implemented flour-dust exposure reduction measures in bakeries participating in 1999-2002, and to assess the potential impact of these measures on the exposure to flour dust.

Eligibility criteria:
inclusion criteria: * employed in a bakery for more than 6 months * and/or participant of the investigations done in 1999-2002 in 6 bakeries
study and treatment of post lyme disease (stop-ld)

Conditions: Lyme Disease

Summary: the purpose of this study is to see how well antibiotics work in reducing chronic fatigue symptoms, such as tiredness, in patients that were treated for lyme disease. fatigue is a common symptom of lyme disease. when fatigue does not improve after treatment, patients are considered to have post lyme syndrome (pls). the chronic fatigue seen in these patients appears to be related to the initial infection which causes lyme disease. it is believed, but not proven, that treatment with antibiotics may be effective in relieving chronic fatigue in pls patients.

you will be assigned randomly (like tossing a coin) to receive either antibiotics or a placebo (sugar pill). neither you nor your doctor will know which you are receiving. you will learn to give yourself the injection, and you will remain on your study drug for 28 days. a home health care nurse will visit you twice a week to check the injection site, and at weeks 1 and 3 the nurse will draw blood for laboratory tests. at months 1 and 6, you will be examined to see if you have fewer chronic fatigue symptoms after the antibiotics. this will include a fatigue questionnaire, a test of your mental processing speed, and a test of your cerebrospinal fluid.

Eligibility criteria:
inclusion criteria: you may be eligible for this study if you: * are between 18 and 65 years of age. * are a resident of long island or greater ny metropolitan area. * are fluent in english. * have a history of lyme disease. * have completed antibiotic treatment for lyme disease 6 or more months before starting the study. * have severe fatigue. * are not pregnant or planning to be pregnant. exclusion criteria: you will not be eligible for this study if you: * have or have had major medical, neurologic, or psychiatric disorder. * have had prior chronic pain, fatigue, or recurrent severe headaches before the onset of lyme disease. * have had fibromyalgia syndrome. * have a history of sleep apnea, narcolepsy, or other serious sleep disorder. * have a learning disability. * have had head trauma requiring hospitalization. * have symptomatic gallbladder disease. * are anemic. * abuse alcohol or illicit drugs. * have been treated with another antimicrobial agent for lyme disease within 6 months of study. * need to be receiving systemic steroid therapy during drug administration and follow-up. * have used benzodiazepines within 1 month of study entry. * are allergic to beta lactams (a class of antibiotics).
the effect of antiplatelets therapy on saphenous vein coronary artery bypass graft patency

Conditions: Coronary Artery Disease

Summary: this protocol is designed to evaluate the effect of antiplatelets (tirafiban and prasugrel) on the incidence of early and intermediate graft patency after cabg.

coronary artery bypass graft (cabg) surgery is a commonly used revascularization strategy in patients with severe coronary artery disease. saphenous vein grafts (svgs) are the most frequently used conduits for this procedure. unlike arterial grafts, svgs are particularly susceptible to occlusive thrombosis during the first post-operative year, which exposes patients to increased risks of death, myocardial infarction, and repeat revascularization. this study is designed to evaluate the effect of antiplatelets (tirafiban and prasugrel) on the incidence of early and intermediate graft patency after cabg. patients will undergo planned cardiac computed tomographic angiography (cta) predischarge (at 1 week) and cta/coronary angiography (cag) at 6 months to 1 year follow-up. cta at baseline (predischarge) and follow-up cta/cag at 6-12 months after cabg will be used to evaluate graft patency.

Eligibility criteria:
inclusion criteria: * all comer study where all patients undergoing coronary bypass surgery (cabg) will be randomized to one of the four treatment groups exclusion criteria: * acute myocardial infarction (ami) or cardiogenic shock * aortic dissection * mechanical valves. * contraindication to antiplatelets or aggrastat. * active bleeding or high risk of bleeding. * history of hemorrhagic stroke any time. * recent history of embolic stroke or transient ischemic attack (tia) less than 3 months. * active peptic ulcer disease (pud). * liver derangement. * warfarin use. * heparin-induced thrombocytopenia (hit) syndrome. * thrombocytopenia (platelet count \<100,000/mm3), disorders of platelet function
time-restricted eating for postpartum weight loss

Conditions: Postpartum Weight Retention; Overweight and Obesity

Summary: this study is being done to assess the feasibility and acceptability of a time-restricted eating intervention among postpartum women with overweight/obesity.

existing postpartum weight retention (ppwr) interventions have had limited success. timing-based interventions, such as early time-restricted eating (etre), show significant improvements in cardiometabolic endpoints in non-postpartum cohorts. the purpose of the time4mom study is to conduct a pilot randomized trial of a postpartum-adapted etre intervention to test feasibility and acceptability of the etre intervention and trial protocol. we will also compare changes in clinical outcomes of interest and patient-reported outcomes between etre (intervention) and control groups. this 2-arm trial will randomize 60 postpartum women to either control or etre for 12 weeks (n=30/group).

Eligibility criteria:
inclusion criteria: * 18 years of age or older * experienced a healthy singleton pregnancy * 6-16 weeks postpartum at enrollment * body mass index ≥25 at enrollment * willing to consent exclusion criteria: * self-reported major health condition (such as renal disease, cancer, or type 1 or type 2 diabetes) * current treatment for severe psychiatric disorder (such as schizophrenia) * self-reported diagnosis of anorexia or bulimia * current use of medication expected to significantly impact body weight * current substance abuse * participation in another dietary and/or weight management intervention postpartum * performing overnight shiftwork \>1x/week * regularly fasting ≥14 hr/day or completing twelve or more 24-hr fasts within the past year * unable to understand and communicate in english

Keywords: postpartum weight management time-restricted eating
study to determine the utility of wound vacuum assisted closure (vac) compared to conventional saline dressing changes

Conditions: Wounds; Compartment Syndromes

Summary: the purpose of this study is to look at the use of the wound vacuum assisted closure (vac) versus standard wet to dry dressing in treating lower leg fasciotomies.


Eligibility criteria:
inclusion criteria: * four compartment fasciotomies performed on one or both lower extremities * subject and/or subject's legally authorized representative (next-of-kin) has voluntarily signed and dated informed consent. exclusion criteria: * inability to place wound vac * contraindications for wound vac use * pregnant females * prisoners

Keywords: wounds-open
point of care ultrasound in pregnant women (pocus-ob)

Conditions: Obstructive Sleep Apnea (OSA)

Summary: pregnant women with gestational age more than 20 weeks are at risk of developing obstructive sleep apnea (osa). osa is a common underdiagnosed comorbid condition in pregnant women associated with adverse maternal and fetal outcomes. it is a severe form of sleep-disordered breathing (sdb), featured with repeated episodes of airflow reduction or cessation during sleep. it exists in different severity among pregnant women and maybe worsen over the course of the pregnancy. if osa remains untreated, it can complicate the pregnancy by developing heart failure, gestational diabetes, pre-eclampsia, eclampsia, and hypertension. to determine the osa during pregnancy has become an important issue to reduce the morbidity related to it. currently, polysomnography (psg) remains the gold standard for diagnosing osa, but scheduling and logistics remain significant impediments to accessibility for pregnant women. home sleep apnea tests (hst) is a promising alternative but are expensive and not widely available. point of care ultrasonography (pocus) is being increasingly used across specialties. our preliminary data support the feasibility of pocus in the preoperative setting and increasing the diagnostic accuracy and the specificity for moderate to severe osa (ahi \>15 events per h) when combined with the stop-bang questionnaire (cut-off \>5). given that hst shows high levels of agreement with psg for the diagnosis of osa and are significantly less burdensome than psg, investigators will evaluate the pocus airway examination against the hst for the diagnosis of osa in pregnant women at high risk of osa.

this project is to define the range of mouth and tongue dimensions and to visualize airway structures by using ultrasound. given that home sleep apnea tests (hst) shows high levels of accuracy for the diagnosis of obstructive sleep apnea (osa), investigators hypothesize that the point of care ultrasonography (pocus) airway examination against the hst for the diagnosis of osa in pregnant women at the high-risk can, 1. reliably visualize upper airway structures that are responsible for osa; 2. objectively measure airway soft tissue thickness and dimensions; and 3. identify pregnant women with moderate-severe osa.

Eligibility criteria:
- inclusion criteria * pregnant women ≥ 18 years of age * at \> 20 weeks of gestation * asa physical status i - iv * with untreated recently diagnosed (within the previous 12 months) osa or at high risk of osa will be eligible for inclusion. high risk of osa will be defined as outlined by facco et al. and recommended by recently updated guidelines (i.e., score ≥ 75) (8). - exclusion criteria i) past history of oral, head or neck surgery (e.g., corrective surgery for osa) ii) active head and neck disease (e.g., cancer, infection, radiotherapy etc.) iii) inability to perform hst per instruction iv) patients with diagnosed osa on cpap therapy

Keywords: osa,pregnancy,women,hst,ultrasound
pregabalin treatment for trigger points

Conditions: Myofascial Pain Syndrome

Summary: myofascial pain syndrome (mps) is a common problem in the general population. mps should not be a local/peripheral painful syndrome and considered to be a syndrome of central sensitivity. we aimed to investigate the effect of pregabalin in patients with mps in this study

we randomized 40 patients into two groups, and 17 patients per group completed the study. patients in group i received pregabalin and exercise therapy, whereas those in group ii received exercise therapy alone. all patients were evaluated as follows: for pain by vas; trigger-point pressure pain threshold-(ppt) by algometry; neuropathic pain using dn4 and quality of life with the sf36. evaluations were performed pretreatment and at the end of the first and third months of treatment.

Eligibility criteria:
inclusion criteria: * patients who diagnosed fibromyalgia syndrome, * patients who were also diagnosed as cervical myofascial pain syndrome based on the upper trapezius muscle exclusion criteria: * patients who had received dry needling or local anesthetic injection to trigger point in the dominant upper trapezius muscle within 3 months of the start of the study. * renal insufficiency, * impaired liver function, * malignancy, * pregnancy * infections, * history of drug or alcohol abuse

Keywords: fibromyalgia, trigger point, myofascial pain, pregabalin
natural evolution of av conduction disorders in patients implanted with cardiac pacemakers

Conditions: Patients Implanted With a Pacemaker

Summary: observational study to assess av block incidence and their evolution according to paroxysmal atrial arrhythmia.


Eligibility criteria:
inclusion criteria: * sinus node disease * brady-tachy syndrome * suspected or documented paroxysmal avb exclusion criteria: * permanent high degree avb * contra indication to the safer pacing mode * pr higher than 350 ms

Keywords: av block, snd, bts, aaisafer, safer, pm implanted
brief self-compassion program in colorectal cancer

Conditions: Colorectal Cancer

Summary: in this study, between 1 december 2024-31 march 2025, who met the inclusion and exclusion criteria, a total of 66 patients with colorectal cancer at the etlik city hospital general surgery department.

brief self-compassion program will be held in a face-to-face hospital environment for the patients with colorectal cancer in the experimental group. this training program has been developed based on the concepts of mindfulness-based compassionate living and mindfulness-based stress reduction programs. the content and topics of the sessions in the program are arranged according to the conceptual structure and flow of the mindfulness-based model. the training program was created in a certain flow, based on the introduction to a short self-compassion program (1 sessions), the importance of self-compassion and self-care in the cancer experience (1 sessions), a self-compassionate approach to challenging emotions and situations (1 sessions). there are 3 sessions in the program and the frequency of sessions is 3 times a week, and each session lasts approximately 45 minutes. the training program will be applied to 33 patients with colorectal cancer in the experimental group.

Eligibility criteria:
inclusion criteria: * 18 years of age and older * can speak and understand turkish * has written permission * being hospitalized in the general surgery clinic of the relevant institution on the dates of the study * diagnosed with colorectal cancer * having no mental illness that would prevent participation in the study exclusion criteria: * not knowing the diagnosis * receiving or having received any psychosocial support or training * having previously participated in programs related to self-compassion * being meditating * having any history of mental retardation or organic brain damage that would prevent participation in the training * having a problem with understanding and following the given instructions

Keywords: cancer self-compassion self-care colorectal cancer randomized controlled trial
phase 3 study to evaluate the safety and efficacy of ypeg-rhg-csf in malignancies receiving chemotherapy

Conditions: Non-Myeloid Malignancy

Summary: this phase 3 study is aimed to evaluate the safety and efficacy of ypeg-rhg-csf in reducing the infection manifested by febrile neutropenia in patients with non-myeloid malignancy who receiving myelosuppressive chemotherapy which is likely to cause clinically significant febrile neutropenia.


Eligibility criteria:
inclusion criteria: * histopathology and/or cytology diagnosed as breast cancer (bc) or non-small cell lung cancer (nsclc), and patients with breast cancer is suitable to receive tac(docetaxel,doxorubicin combined with cyclophosphamide) chemotherapy, while patients with nsclc is suitable to receive dc(docetaxel combined with carboplatin) chemotherapy. * age ≥18 yrs. * weight ≥45 kg. * karnofsky score ≥ 70. * life expectancy ≥ 3 months. * peripheral blood test: wbc≥3.5×10\^9 cells/l, plt≥100×10\^9 cells/l. anc≥1.5×10\^9 cells/l. * understand and voluntarily sign the informed consent form. exclusion criteria: * receiving chemotherapy within two months prior to screening. * previously or plan to receive radiotherapy (\>25% total bone marrow volume). * evidence of tumor metastasis in bone marrow. * lack of awareness. * uncontrolled infection or using of antibiotics within 72hrs prior to screening. * previously received or plan to undergoing bone marrow or organ transplants. * patients with bleeding tendency, e.g. prolonged prothrombin time of more than 3 seconds. * dysfunction in heart,lung, liver, kidney, or other major organs or systems; alt\>2.5 uln (upper limit of normal), tbil \>2.5 uln (alt\>2.5 uln, total bilirubin \>2.5 uln for patients with liver metastasis), hbsag positive, anti-hcv positive, evidence of liver decompensation, or cr \>1.5 uln. * pregnant or lactating females. * malignancy other than bc or nsclc. * hypersensitivity to rhg-csf or any component of the investigational products. * subject enrolled in any other studies within 3 months prior to screening. * drug abuser or alcoholics. * any other conditions which in the opinion of the investigator precluded enrollment into the study.

Keywords: g-csf human granulocyte colony-stimulating factor febrile neutropenia neutropenia myelosuppressive chemotherapy fn
bone loss in men on androgen blockade as adjuvant therapy for prostate cancer

Conditions: Prostate Cancer; Bone Loss

Summary: patients with advanced prostate cancer undergoing adjuvant treatment with androgen blockade will be followed over a 1 year interval to assess the effects of this treatment on bone metabolism. it is expected that men undergoing androgen blockade will experience accelerated bone loss.


Eligibility criteria:
inclusion criteria: * men * age of 40 years or greater * diagnosis of advanced prostate cancer (ie: prostate-specific antigen \[psa\] less than 25 ug/l and undergoing continued treatment with leuteinizing hormone-releasing hormone \[lhrh\] therapy) * willing and able to consent exclusion criteria: * metastatic disease to bone * medications affecting bone turnover (bisphosphonate, steroids, anticonvulsant) * renal failure (serum creatinine \> 200 umol/l) * co-morbidity factors affecting bone density (ie: paget's, rheumatoid arthritis) * factors affecting ability to perform the bone density tests using femoral head measurements (ie: bilateral hip arthroplasty) * cancer other than skin, except when, in the investigators' opinion, it is determined to be appropriate and not adversely affect the outcome of the trial * gastrointestinal (gi) pathology (eg. malabsorption syndrome) * parathyroid disease
an observational study of stroke patients.

Conditions: Quality of Care; Cerebrovascular Disorders; Hyperglycemia; Hypertension; Troponin

Summary: the intention is to study presumed changes in daily practice, probably due to new guidelines concerning stroke patients. the impression is more frequent measurements of blood pressure, serum glucose, troponin and supplementary computer tomography or magnetic resonance imaging.

there is in general a focus on misuse of health resources. an increasing amount of guidelines is produced to reduce the variation in treatment of patients with the same diagnosis. many recommendations are weak but seems though to have considerable impact on in hospital care. the issues to be studied are all grounded on weak clinical evidence. a pilot study confirmed the suspicion of very frequent measurements of blood pressure, glucose, troponin and frequent supplementary ct and mri. the intention is to study these issues in a larger population including an evaluation of utility of the different examinations and evaluations.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of stroke according to icd 10th revision (code i61 i63 and i64) * hospitalized between january 1 and december 31, 2015 exclusion criteria: * previous hospitalization with a diagnosis of stroke in 2015. * foreigners and patients from other regions of norway.
characterization of enterococcus faecalis endocarditis and impact of amoxicillin mic elevation on patient outcome

Conditions: Infectious Endocarditis

Summary: infective endocarditis is a complex infection that can be life-threatening. these infections also cause anatomical lesions that can be severe. their management is complex and involves several disciplines: cardiology, bacteriologists, infectious diseases specialists, radiologists, nuclear medicine specialists, cardiac surgeons, neurologists, pharmacologists, etc. the incidence of enterococcus faecalis endocarditis is increasing due to the aging of the population and the disappearance of rheumatic fever. the adequate management of these infections is complex and relies on the prolonged administration of high-dose antibiotics, classically the combination of amoxicillin and ceftriaxone. in the context of streptococcal endocarditis, the impact of increasing the minimum inhibitory concentration (mic) of amoxicillin on patient mortality has been demonstrated but no study has yet examined the impact of increasing the mic of amoxicillin on the outcome of patients treated for enterococcus faecalis infective endocarditis.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age with a diagnosis of enterococcus faecalis infective endocarditis based on duke criteria * patient hospitalized in one of the participating centers * french-speaking patient exclusion criteria: * patient with suspected infective endocarditis who does not meet duke criteria * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of their data for this research