Kornimate/medical-research-clean huggingface dataset:
effects of interactive sensory play on manual dexterity in down syndrome

Conditions: Down Syndrome

Summary: down syndrome is a genetic condition in which a patient has an extra chromosome which is a copy of chromosome 21. it causes physical, cognitive, and behavioral symptoms. the person has difficulty with normal life activities. this study evaluates the effect of interactive sensory play on coordinated hand movements or manual dexterity in children with down syndrome. down syndrome is one of the most common birth defects and causes impairments in the body. the children diagnosed with down syndrome need great deal of therapies in early childhood so that can live a better life. the objective of this study is to assess the effects of interactive sensory play on manual dexterity in down syndrome children. the study design will be a randomized controlled trial. the study setting will be tehsil headquater hospital sadiqabad. the study duration will be 10 months after the approval of the synopsis. the sample size will be 22 which is calculated by epitools. the sampling technique will be a non-probability convenient sampling technique. children who are diagnosed with down syndrome will be included. children with other musculoskeletal and neurological issues will be excluded. data collection tools will be box and block test and pediatric evaluation of disability inventory. identification and recruitment of the participants with down syndrome will be done. participants will be selected through lottery for both groups. group 1 will use interactive sensory play and group 2 will use free play as intervention. the assessor will be blind. the data will be analyzed using spss 23.


Eligibility criteria:
inclusion criteria: * children with moderate level of mental retardation who are able to follow commands exclusion criteria: * • children with other musculoskeletal and neurological issues. * children with down syndrome but also have complications such as epilepsy, congenital heart condition.

Keywords: interactive sensory play manual dexterity free play
dysfunctional breathing in individuals with thoracic outlet syndrome

Conditions: Thoracic Outlet Syndrome

Summary: the aim of this observational study was to learn about the characteristics of dysfunctional breathing in individuals with thoracic outlet syndrome. the main question to be answered is: is there a dysfunctional breathing pattern in individuals with thoracic outlet syndrome? these features will be compared with a healthy control group to evaluate the association of thoracic outlet syndrome with dysfunctional breathing


Eligibility criteria:
inclusion criteria: * to agree to participate in the study, * to have been diagnosed with tos by a thoracic surgeon, * to be between 18-65 years old, * having pain for more than 6 months exclusion criteria: * patients with a history of spinal or thoracic surgery for tos or any other reason, * people with traumatic cervical injury, * severely obese people (bmi \>40 kg/m2), * people with clinical abnormalities in the thoracic cage or vertebral column, * persons with occupational industrial exposures, * patients with severe comorbidities (neurological, neuromuscular, -cardiorespiratory, psychiatric and musculoskeletal) diabetes mellitus and/or malignancies

Keywords: thoracic outlet syndrome dysfunctional breathing
identifying new genetic causes to development disorders

Conditions: Disorders of Sex Development; Growth Disorders; Puberty Disorders

Summary: disorders of growth, puberty and sex development can have genetic causes. the exome analysis could detect new mutations responsible for these disorders and the frequency of these mutations in these disorders, their association with other malformations.


Eligibility criteria:
inclusion criteria: * congenital growth hormone deficiency * puberty disorder * gonadal dysgenesis or anorchia * primary ovarian failure * disorder of sex development * subjects related to a patient with one of the above criteria exclusion criteria: * environmental or auto-immune cause
quality of life (qol) following parathyroid surgery

Conditions: Parathyroidectomy

Summary: the only established treatment for the complete resolution of hyperparathyroidism is the surgical removal of the affected glands. while proven as a means of resolving hyperparathyroidism, there have been no comprehensive preoperative and postoperative assessments to determine quality of life for patients undergoing minimally invasive vs. traditional parathyroid surgery. quality of life will be assessed in subjects undergoing minimally invasive procedures and traditional procedures using a clinically validated survey. we will gather data one week preoperatively as well as one week and one year postoperatively then compare the survey results from the two study groups to each other. we will also compare the study groups to a control group consisting of patients undergoing thyroid surgery. our ultimate goal is to clarify if minimally invasive parathyroid surgery techniques contribute to a higher patient quality of life as compared to traditional techniques.


Eligibility criteria:
inclusion criteria: * parathyroidectomy exclusion criteria: * subjects under the age of 18
ganciclovir 0,15% ophthalmic gel in the treatment of adenovirus keratoconjuntivitis

Conditions: Conjunctivitis, Viral; Adenoviridae Infections

Summary: ganciclovir ophthalmic gel delivers multiple advantages in the treatment and prophylaxis of herpetic keratitis and shows potential for effectiveness against other viral ocular infections. the majority of adenoviral conjunctivitis will resolve without damaging vision, however, the investigators have no way to determine which cases will progress to ocular complications such as corneal infiltrates and pseudomembranes. our purpose is to evaluate the efficacy of the ganciclovir gel 0.15% in preventing ocular complications after adenoviral conjunctivitis.


Eligibility criteria:
inclusion criteria: * onset of symptoms for five days or less * eighteen years old or more * not pregnant or breastfeeding * be able to understand and sign the consent term exclusion criteria: * use of antibiotic or corticoid 30 days before * monocular vision * keratopathy or other ocular diseases

Keywords: conjunctivitis, viral adenoviridae infections ganciclovir adenovirus keratoconjunctivitis treatment of viral conjunctivitis
comparison on the efficacy of endoscopic snare papillectomy with or without submucosal injection

Conditions: Ampulla of Vater Adenoma

Summary: because the ampulla of vater is strategically located at the confluence of the pancreatic and common bile ducts, endoscopic resection of papillary neoplasms may be technically different from endoscopic mucosal resection in other parts of the gastrointestinal tract. the best method of endoscopic ablation and the optimal period for surveillance have not been established.

while some endoscopists advocate the use of submucosal injection of either physiologic saline solution or dilute epinephrine, some do not. whether physiologic saline solution or dilute epinephrine should be used is also not established. submucosal injection of either dilute epinephrine or saline solution may be useful for avoiding inappropriate resection because failure to lift the tumor from the proper muscle layer of the duodenum may indicate deeper invasion18 and is the strongest predictor of malignancy. in adenomas of the major duodenal papilla, however, some investigators do not recommend submucosal injection. not only the surrounding mucosa at the region of the duodenal papilla but also the tumor is lifted by submucosal injection, so capturing the lesion with a snare becomes difficult.

Eligibility criteria:
inclusion criteria: * ampulla of vater adenoma * no uncontrolled coagulopathy exclusion criteria: * adenocarcinoma of ampulla of vater * uncontrolled coagulopathy * refusal to this study

Keywords: ampulla of vater adenoma papillectomy injection non-injection
attitudes towards receiving mental health care using telehealth during the coronavirus disease 2019 (covid-19) pandemic

Conditions: Psychiatric Disorder; Mental Health Disorder; Stress; Adjustment Disorders

Summary: the purpose of this study is to collect patients' experiences and feedback to better understand and improve mental health care using telehealth services. this is critically important as telehealth appointments, including both phone and video calls, continue to be offered for regular appointments to reduce in-person interaction as a preventive measure to help control the spread of covid-19.

studying patients' perceived benefits and challenges of using telehealth services for mental health care will allow us to prioritize improvements to the telehealth experience and potentially, patient adoption of and comfort with remote appointments. this study's results would also inform policy makers and insurance companies about the potential utility of delivering mental health care through telehealth, even beyond the duration of the covid-19 pandemic.

Eligibility criteria:
inclusion criteria: * adults age 18 and over who received mental health care through northwestern prior to telehealth implementation from march 15th 2019 to march 14th 2020, and had at least one mental health care appointment through northwestern between march 15th 2020 and september 30th 2020. exclusion criteria: * adults unable to access study questionnaires via computer or mobile device

Keywords: telehealth telemedicine telepsych telepsychiatry telepsychology telemental health survey attitudes covid-19 pandemic mental health therapy psychiatry
evaluation of hearing preservation in adults with partial low-frequency hearing implanted with the hifocus™ mid-scala electrode

Conditions: Hearing Loss; Deafness; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases

Summary: the purpose of this study is to determine the feasibility of preserving low-frequency acoustic hearing in adults with a moderate degree of hearing loss in the low frequencies and severe-to-profound hearing loss in the mid-to-high frequencies who are implanted with the hires™ 90k advantage implant with hifocus™ mid-scala electrode.


Eligibility criteria:
inclusion criteria: * no previous cochlear implant experience * 18 years of age or older * up to a moderate sensorineural hearing loss in the low-to-mid frequencies (pure tone average ≤ 65 db hl for 125, 250, 500, and 1000 hz) and a severe-to-profound sensorineural hearing loss in the high frequencies (pure tone average ≥ 70 db hl for 2,000, 4,000, and 8,000 hz) in the ear to be implanted * aided monosyllabic word score of 10-50% in the ear to be implanted * up to a moderate sensorineural hearing loss in the low-to-mid frequencies (pure tone average ≤ 65 db hl for 125, 250, 500, and 1000 hz) and a severe-to-profound sensorineural hearing loss in the high frequencies (pure tone average ≥ 70 db hl for 2,000, 4,000, and 8,000 hz) in the contralateral (non-implanted) ear * english language proficiency * willingness to participate in all scheduled procedures outlined in the protocol exclusion criteria: * previous inner ear surgery * cochlear malformation or obstruction that would preclude full insertion of electrode array * presence of additional disabilities that would prevent or interfere with participation in the required study procedures * medical or psychological conditions that contraindicate surgery or impact the ability to manage an implanted device or the study-related procedures * evidence of central auditory lesion or compromised auditory nerve

Keywords: cochlear implant hires™ 90k advantage implant cochlear implantation hifocus™ mid-scala electrode listening benefits adults cochlear implant benefit hires fidelity 120™ electrical stimulation
amino acid metabolism before and after bariatric surgery

Conditions: Obesity, Morbid

Summary: this observational study aims to investigate the changes in serum amino acid metabolism before and after bariatric surgery in obese individuals. blood samples will be collected from 50 patients at baseline (preoperative), and at 1 and 3 months postoperatively. an additional 50 healthy individuals will serve as the control group. amino acid profiling will be conducted using lc-ms/ms. the study seeks to determine how bariatric surgery affects metabolic pathways associated with amino acid regulation.

obesity is a major global health problem that significantly increases the risk of metabolic disorders. bariatric surgery is one of the most effective interventions for sustained weight loss in morbidly obese patients. however, the metabolic effects of such surgery on amino acid profiles are not fully understood. in this prospective observational study, a total of 100 participants will be enrolled: 50 patients undergoing bariatric surgery and 50 healthy controls. serum samples will be collected from the patient group preoperatively, and at 1 and 3 months after surgery. the control group will provide one-time blood samples. all serum samples will be centrifuged and stored at -80°c until analysis. free amino acid profiles will be determined using liquid chromatography-tandem mass spectrometry (lc-ms/ms). the primary outcome is to assess the change in amino acid concentrations over time in surgical patients, and to compare them with healthy controls. secondary analyses will explore correlations between amino acid levels and body mass index (bmi). data analysis will be performed using spss and metaboanalyst 5.0. this study will help clarify how bariatric surgery influences amino acid metabolism and may offer insights into the metabolic mechanisms underlying postoperative recovery and weight regulation.

Eligibility criteria:
inclusion criteria: * age ≥18 years * diagnosed with obesity and scheduled for bariatric surgery (study group) * healthy individuals with normal bmi (control group) exclusion criteria: * age \<18 years * history of metabolic or chronic systemic disease * pregnancy or lactation
evaluation of a combined parent-student programme for smoking prevention in berlin schools

Conditions: Tobacco Use Disorder

Summary: the purpose of this study is to evaluate the effectiveness of a combined parent-student program for smoking prevention in 7th graders in berlin schools.

the hazardous health effects of smoking and second hand smoke are well known and published. despite wide spread tobacco prevention campaigns and initiatives, the proportion of children and adolescents who smoke remains high, especially in germany. current research indicates that comprehensive strategies, especially with a parental involvement component, appear to be the most effective school-based smoking prevention programs. a popular smoking prevention program in the city of berlin is the karuna interactive show jumping course "still smoking or already alive?" ("rauchst du noch oder lebst du schon?" mitmach - parcours). this parcours was designed to teach facts about smoking and its health-damaging effects, its negative effects on physical appearance, to promote communication and to enhance participants' awareness of social pressure and their self-efficacy to deal with these situations. no study to date has evaluated its effectiveness in reducing smoking rates among participating students. the study aim is to test the effectiveness of an interactive combined student-parent intervention in 7th graders regarding the reduction of smoking rates among secondary school children aged 12-15 compared to no smoking prevention intervention using self-reported questionnaires. in addition, it will be tested whether the program that involves the combination of a student and a parent intervention is more effective in the reduction of smoking rates in comparison to a program without a parental intervention.

Eligibility criteria:
school inclusion criteria a school is eligible for the study if * it is located in berlin * has 7th grade classes (students between 12-15 years) school exclusion criteria: * schools offers an extensive smoking prevention program for their students that includes parental involvement. * schools that do not agree to stop visiting the karuna e.v. smoking parcours (if they do) for the next two years in case of being randomized to the control group. * schools that do not agree to have a parents' night (separate or part of the typical parents' nights) where trained health coaches will introduce and discuss the topic of smoking prevention in youth in case of being randomized to the combined student-parent intervention. student inclusion criteria a student is eligible for the study if * female or male in the 7th grade * signed written assent * intellectual and physical ability of participant to make an informed decision about study participation * attends one of the participating schools * has signed approval from parent/caregiver

Keywords: tobacco use adolescents primary prevention program effectiveness parental component
a phase ib/ii clinical trial to evaluate the safety and efficacy of lg00034053 in patients with knee oa

Conditions: Osteoarthritis, Knee

Summary: this study is a multi-center, randomized, placebo-controlled, double-blind clinical study, consisting of part 1 (phase 1b) in a sequential, dose-escalating design and part 2 (phase 2) in a parallel design.


Eligibility criteria:
inclusion criteria: * patients diagnosed with primary osteoarthritis of the knee according to the acr clinical criteria, with kellgren-lawrence grade 2 to 3 in the corresponding knee as determined in the x-ray test * patients with pain in the index knee requiring nsaids or analgesics which sustained for at least 6 months * patients with a score of ≥ 4 and ≤ 9 in response to question 1 (walking pain) on the womac pain subscale (11-point nrs) * patients with the subtotal score of ≥ 20 and ≤ 45 on the womac pain subscale (11- point nrs) * patients with bmi at or below 40 kg/m2 exclusion criteria: * patients with chronic pain requiring continuous treatment * patients with rheumatoid arthritis or other inflammatory arthritis * patients with skin disorders at the administration site * patients with clinically significant renal or cardiovascular disease or those with suspected sars-cov-2 infection * patients in a medical condition which may affect the efficacy and/or safety assessment * patients with kellgren-lawrence grade 4 in the contralateral knee * patients with tense effusion * patients having administered an opioid analgesic/ other analgesic/health functional foods, single dose of ia injection within a certain period prior to drug administration * patients having undergone knee replacement
optical coherence tomography of the airway for lung cancer or lung disease

Conditions: Lung Cancer; Malignant Mesothelioma; Metastatic Cancer; Nonmalignant Neoplasm; Precancerous Condition

Summary: rationale: diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells. purpose: this phase i trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

objectives: * correlate optical coherence tomography images of the airway with airway histology. * develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer. outline: bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. all imaged areas are marked. the marked areas are then excised and fixed in formalin for histopathologic analysis.

Eligibility criteria:
disease characteristics: * undergoing pneumonectomy or lobectomy for malignant or benign lung processes patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: non-small cell lung cancer small cell lung cancer benign respiratory tract neoplasm lung papilloma recurrent respiratory papillomatosis squamous lung dysplasia malignant mesothelioma pulmonary carcinoid tumor lung metastases
procedures, complications and follow-up of tracheostomy in intensive care units.

Conditions: Respiratory Failure; Neurological Disease; Heart Failure; Airway Management

Summary: tracheostomy is worldwide used for critically ill patients. the aim of our study is to assess the mortality, quality of life, laryngeal function, procedures, early and late complications of tracheostomy performed for critically ill patients admitted in intensive care units.


Eligibility criteria:
inclusion criteria: * age \> 18 years * indications for tracheostomy exclusion criteria: * infection/inflammation of neck tissue * previous neck surgery causing abnormal anatomy of the site * recent surgery of cervical spine
vancomycin dosing for serious mrsa infections: a non-inferiority randomized trial of trough level versus auc/mic

Conditions: MRSA

Summary: intravenous vancomycin is considered first line therapy for serious methicillin-resistant staphylococcus aureus (mrsa) infections including bacteremia, central nervous system infection, pneumonia, pleural space infection, bone or joint infection, prosthetic joint infection and deep abscesses. the effectiveness and toxicity of vancomycin depend on its dosing and chosen target. the most recent guidelines suggest targeting area under the curve over 24 hours over minimum inhibitory concentration (auc/mic) of 400 to 600. implementation of auc/mic requires bayesian software that can be variable, costly, complicated and time consuming. ideally, auc/mic dosing would also require susceptibility testing by broth microdilution, which is not commonly done. it is recommended to target auc of 400 to 600 assuming a mic of 1ug/ml when mic by broth microdilution is not known. targeting a trough level of 10 to 15mg/l may be a reasonable and more practical alternative without compromising effectiveness. we will be conducting a randomized controlled non-inferiority trial to compare intravenous vancomycin dosing strategy targeting a trough level of 10 to 15mg/l versus auc of 400 to 600 assuming a mic of 1ug/ml by broth microdilution for serious mrsa infections. the primary outcome will be treatment failure, which is a composite of mortality and microbiologic failure at 90 days. we hypothesize that targeting a trough level of 10 to 15mg/l is non-inferior to targeting a auc of 400 to 600 in terms of treatment failure. the criterion for non-inferiority is that a two-sided 95% confidence interval for difference in risk of treatment failure will lie within the non-inferiority margin of 10%.


Eligibility criteria:
inclusion criteria: * adult patients with serious mrsa infections based on culture results including bacteremia, pneumonia, pleural space infection, central nervous system infection, bone infection, septic arthritis, prosthetic joint infection, and deep abscess * enrolment within 4 days from date of mrsa culture collection * patient either currently not on vancomycin or has received vancomycin for 4 days or less exclusion criteria: * vancomycin minimum inhibitory concentration (mic) ≥2ug/ml * patient is palliative or expected to die in the next 48 hours, or requires critical care resources but will not receive it due to advanced care directives * history of type 1 hypersensitivity reaction to vancomycin * patients on intermittent hemodialysis or peritoneal dialysis

Keywords: vancomycin mrsa trough auc
the effect of the modified perineal protection device during delivery

Conditions: Perineal Tears.

Summary: the purpose of this study is to determine whether a modified perineum protection device can reduce tearing during delivery.

rct investigation using a modified device during delivery of the baby's head (an earlier model has proved successful) and assess whether the use can decrease delivery tears as measured in length.

Eligibility criteria:
inclusion criteria: * vaginal delivery at term (week 36 - 41) exclusion criteria: * age below 18 * breech delivery * not understanding written and oral information

Keywords: delivery tears birth injuries perineal protection device