Kornimate/medical-research-clean huggingface dataset:
rifabutin therapy for the prevention of mycobacterium avium complex (mac) bacteremia in hiv positive patients with cd4 counts = or < 200: treatment ind study

Conditions: Mycobacterium Avium-intracellulare Infection; HIV Infections

Summary: primary: to provide rifabutin to hiv positive patients in an attempt to prevent or delay mycobacterium avium complex (mac) infection by a daily dose of rifabutin. secondary: to further characterize the safety of rifabutin monotherapy in preventing or delaying mac bacteremia in hiv positive patients with cd4 counts = or \< 200.


Eligibility criteria:
inclusion criteria concurrent medication: allowed: * any medication with the exception of other investigational drugs not available under a treatment ind, expanded access, or parallel track program. patients must have: * confirmed hiv infection. * cd4 cell counts \<= 200 cells/mm3. * no evidence of disseminated mac disease. * informed consent of parent or guardian if 12 to \< 18 years of age. note: * pregnant females may be eligible. there are no studies of the safety or efficacy of rifabutin in pregnant women. rifabutin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. in addition, a risk/benefit decision should consider the likelihood of a woman's developing mac if she does not receive prophylaxis. the risk of developing mac rises substantially for women with cd4 counts less than 100, although it can also develop in women with higher cd4 counts. women of reproductive potential who are not pregnant must use contraception. they are encouraged to use means other than oral contraceptives. exclusion criteria co-existing condition: patients with the following symptoms and conditions are excluded: * known hypersensitivity to rifabutin, rifampin, or other rifamycins. * current infection due to mac or other mycobacterial disease, or complaints consistent with tuberculosis. concurrent medication: excluded: * other investigational drugs with the exception of those available under a treatment ind, expanded access, or parallel track program. (licensed products prescribed for unlabeled indications are not considered investigational.) patients with the following prior conditions are excluded: prior infection due to mac or other mycobacterial disease or complaints consistent with tuberculosis.

Keywords: rifabutin acquired immunodeficiency syndrome aids-related complex mycobacterium avium complex bacteremia
online intervention for depression: mood

Conditions: Depressive Symptoms

Summary: the study aims to examine the efficacy and acceptance of a self-help internet intervention "mood" in a sample of individuals with depressive symptoms. it is tested whether depressive symptomatology decreases in the intervention group compared to a wait-list control group. further aims are to ascertain changes in self-worth and quality of life, to assess subjective evaluation of the program and to examine whether expectations of the program's helpfulness would predict symptom reduction.

the study aims to examine the efficacy and acceptance of a self-help internet intervention "mood" in a sample of individuals with depressive symptoms. it is tested whether depressive symptomatology decreases in the intervention group compared to a wait-list control group. secondary aims are to ascertain changes in self-worth and quality of life, to assess subjective evaluation of the program and to examine whether expectations of the program's helpfulness would predict symptom reduction. during the intervention period of six weeks, participants of the intervention group have access to the online program mood. prior and following this period both groups complete a pre- and post-assessment. participants of the wait-list control group receive access to mood following the post-assessment.

Eligibility criteria:
inclusion criteria: * presence of psychological strain and desire for treatment for depressive symptoms * internet access * sufficient command of the german language exclusion criteria: * acute suicidality (as assessed with one item of the bdi) * lifetime diagnoses of bipolar disorder and psychosis
ionized magnesium for monitoring of citrate-anticoagulated cvvhd

Conditions: Intensive Care Unit Syndrome

Summary: it has been reported in several studies that ionized hypomagnesemia is associated with higher morbidity and mortality rates. during continuous renal replacement therapy with regional citrate anticoagulation (crrt-rca), the loss of magnesium has been reported to not be covered by magnesium concentration in ordinary dialysis fluid. this may lead to ionized hypomagnesemia. however the incidence of ionized hypomagnesemia in patients requiring crrt-rca remains unclear and need to be estimated to determine if ionized magnesium monitoring could be of interest. this study aim to assess the incidence of ionized hypomagnesemia induced by crrt-rca.


Eligibility criteria:
inclusion criteria: * consecutive patients admitted to the icu and requiring continuous renal replacement therapy with regional citrate anticoagulation * age \> 18 ans exclusion criteria: * persons under protection * paritcipation rejections

Keywords: continuous renal replacement therapy with regional citrate anticoagulation (crrt-rca) ionized hypomagnesemia monitoring of ionized magnesemia morbi-moratlity
evaluation of the value of cerebral perfusion scintigraphy in the study of post-stroke fatigability

Conditions: Fatigability Post Stroke

Summary: at present there is no consensus for post-stroke imaging except for the realization of early cerebral ct at 24 hours post-thrombolysis. the use of cerebral perfusion scintigraphy would predict the course of a stroke. indeed, it has been shown that a good perfusion is linked to a good evolution of the neurological deficit. this test is used routinely to evaluate cerebral perfusion in patients with stroke. this technique was also used to study the mechanisms of post-stroke aphasia and to highlight neuronal disconnections after stroke, a reflection of the functioning of neural networks. neuropsychological tests are almost always done at 3 months. fatigue is studied: psf scale at 3 months, 6 months and 2 years. research needs to be continued in this area because the pathophysiology remains unknown and the symptoms are disabling for patients. using cerebral perfusion imaging would bring elements of understanding of this mechanism and ultimately improve the management of patients.


Eligibility criteria:
inclusion criteria: * patients: 18 to 60 years old at the initial diagnosis * admission for transient ischemic attack, stroke, dissection, tvc * rankin less than or equal to 2 * neuropsychological tests at +3 months: moca\> 26 (to eliminate cognitive deteriorations too important for the good realization of the battery) * absence of psychiatric history * absence of psychotropic medication * no history of stroke * no complaint of pre-stroke fatigue * having signed the consent form exclusion criteria: * impossibility of giving the subject or his family enlightened information (subject in emergency situation, difficulties in understanding the subject, etc.) * subject under the protection of justice * subject under guardianship or curatorship * refusal of the patient to participate in the study

Keywords: fatigability post stroke post stroke high-speed ct mri
pragmatic posterior capsular stretch

Conditions: Shoulder Impingement; Shoulder Pain; Adhesive Capsulitis; Rotator Cuff Tears; Posterior Capsule Tear; Glenohumeral Subluxation; Glenohumeral Dysplasia; Acromioclavicular; Sprain (Strain); Internal Rotation Contracture-shoulder; External Rotation Contracture-Shoulder; Flexion Contracture; Extension Contracture-Shoulder

Summary: various stretches are used to lengthen the posterior shoulder capsule. no study has reported the comparison of the pragmatic posterior capsular stretch and cross body stertch

background: posterior capsular tightness (pct) is a problem frequently seen in shoulder disorder. pct leads to variation in scapular and humeral kinematics. two techniques considered in our study for regaining normal range of motion at shoulder joint and improving pct, one is the pragmatic posterior capsular stretch (ppcs) \& the other one is cross body stretch (cbs) objective: the aim of our study id to compare the short term effect of ppcs versus cbs on range of motion on shoulder joint in healthy individuals. and to evaluate the feedback of subjects regarding both the interventions. methodology: through rct 30 asymptomatic subjects (15 males, 15 females) . a simple random sampling technique was used. subjects were screen through a functional movement screening tool. the change in hand behind neck and hand behind back will be measured through measuring tape. shoulder rom and functional movements for both the stretches will be campared results:

Eligibility criteria:
inclusion criteria: * age groups of males and females including 20-35 years * subjects who fall in grade 1 and 2 of functional movement screening of shoulder during the screening process. exclusion criteria: * individual with shoulder pain, fracture or dislocation less than 1 year * individuals with any known shoulder pathology * subjects receiving current physiotherapy treatment * subjects having enough range of motion( can reach t2 hand behind neck)
fatigue and sleep in children and adolescents with juvenile idiopathic arthritis: a cross-sectional study

Conditions: Fatigue; Juvenile Idiopathic Arthritis

Summary: the aims of this study is to primarily investigate fatigue and sleep and to secondarily examine possible relationships between disease activity, pain and functional ability in turkish children and adolescents with juvenile idiopathic arthritis (jia).

children with jia become fatigued easily, experience joint inflammation, pain, limited mobility and report poor sleep quality and daytime sleepiness . it is reported in the literature that children with jia suffer from poor sleep, parasomnias, daytime sleepiness, sleep fragmentation, cyclic alternating patterns increase, and sleep-disordered breathing compared to healthy children. sleep was disturbed in almost half of the patients with both jia and juvenile dermatomyositis, and that sleep disturbance and fatigue were both correlated with disease activity. increased pain is associated with more sleep disturbance and more fatigue, and these appear to negatively influence quality of life. so, in this study, fatigue and sleep in turkish patients with jia will be investigated by using specific surveys and also secondarily it will be examined possible relationships between disease activity, pain and functional ability in children and adolescents with jia.

Eligibility criteria:
inclusion criteria: inclusion criteria consisted of a diagnosis of jia according to the international league of associations for rheumatology (ilar) criteria (13), being aged between 6 - 18 years, and being able to read and write in the turkish language. all patients were diagnosed as jia 6 months prior to the study. exclusion criteria: * patients were excluded from study if they had a second rheumatic or another chronic disease, a history of mental deficit or psychological problem or no acceptance for participation in the study by their families.

Keywords: sleep
6-month trial of chinese herbal treatments for hair loss and gray hair

Conditions: Alopecia; Canities

Summary: this will be a 6-month randomized, double-blind, placebo-controlled trial. a total of 152 participants with hair loss, including some with gray hair, will be enrolled and randomly assigned to four groups. each group will receive a combination of oral capsules and hair tonic, to be used as directed for 24 weeks. participants will attend three in-person visits, during which assessments-including hair-related tests and photographs-will be conducted to evaluate hair count and density. additionally, 10 participants with gray hair from each group will undergo extra assessments focused on changes in hair color. all relevant clinical data will be systematically collected and recorded for statistical analysis.


Eligibility criteria:
inclusion criteria: 1. participants must sign the informed consent form prior to enrollment and fully understand the study's purpose, procedures, and potential adverse events. 2. adults aged 18 to 60 years, both male and female; each group must include no less than 50% female participants. 3. hair length must be greater than 5 cm. 4. women must meet the savin scale classification between grades 1-3 to ii. 5. men must meet the norwood-hamilton classification between stages ii and vi. 6. at least 10 participants in each group must have gray hair, with a minimum of 5 gray hairs within a 1 cm × 4 cm area of the scalp. 7. participants must not have undergone any special hair treatments-such as dyeing, perming, or styling-within the past two months. exclusion criteria: 1. pregnant or breastfeeding women, or individuals planning to conceive in the near future. 2. individuals with medical conditions causing hair loss, such as refractory alopecia areata, inflammatory scarring alopecia, or psoriatic alopecia; or those diagnosed with other scalp or hair disorders. 3. individuals with diagnosed psychiatric or psychological disorders, or those with long-term sleep disturbances or emotional regulation issues. 4. use of anti-hair loss cosmetics or other hair growth-promoting products within the past 3 months. 5. use of any systemic or topical medications known to affect hair growth within the past 6 months. 6. history of hair transplantation. 7. curly hair. 8. individuals with highly sensitive constitutions. 9. individuals diagnosed with severe anemia or abnormal liver/kidney function during physical examination. 10. participation in any other clinical trials involving the test area within the past 2 months. 11. any other conditions deemed unsuitable for participation by the clinical investigators.
veteran-centered outcomes using qualitative and quantitative methods

Conditions: Spinal Cord Injury; Stroke

Summary: the purpose of this study is to modify and develop measures that reflect outcomes that are relevant to recovering veterans and are sensitive to improvements resulting from innovative gait interventions.

existing clinically-generated measures, in general, have been developed independent of input from veterans. the purpose of this collaborative study is to take advantage of qualitative and quantitative expertise from the gainesville, florida, rehabilitation outcomes research center (rorc) with state-of-the-art gait intervention research being conducted at the gainesville, brain rehabilitation research center (brrc) and cleveland, functional electrical stimulation center (fesc). three interventions have received considerable attention for their demonstrated promise in improving gait and mobility in individuals with spinal cord injury and stroke; 1) manually assisted locomotor training (mlt), 2) robotic assisted locomotor training (rlt)and 3) functional electrical stimulation assisted gait training (fes-gt). these interventions will be the basis for improving existing outcome measures and developing new outcome measures. the process of developing and evaluating valid outcome measures requires four phases of development. this study encompasses phases i and ii. phase i (year 1 of grant)will involve completing qualitative research studies to identify constructs reflecting the impact of mlt, rlt and fes-gt on veterans. data will be systematically collected using ethnographic field observations and in depth, semi-structured interviews. phase ii (year 2) will involve using the identified constructs to develop item banks for veterans-centered outcome measures.

Eligibility criteria:
inclusion criteria: * patients with stroke and patients with incomplete spinal cord injuries currently enrolled in locomotor/gait training studies at the va brain rehabilitation research center, gainesville, fl and the va functional electrical stimulation center, cleveland, ohio, competence for inclusion in the treatment intervention study (and the present study) is passing the 3-step command component of the mini mental status exam. exclusion criteria: * unable to pass the 3-step command component of the mini-mental exam.

Keywords: ethnography psychometrics qualitative research
shoulder corticosteroid injection in diabetic patients

Conditions: Shoulder Pain; Corticosteroid Injection; Type2 Diabetes Mellitus

Summary: in type 2 diabetic patients affected by chronic shoulder pain, subacromial injection with corticosteroid could be an effective treatment. the aim of this study was to measure the risk-benefit ratio of this treatment.twenty patients with well-controlled diabetes were included in a prospective study. in a first pre-injection phase, patients were asked to measure glycemia for 7 days, before breakfast and dinner, then 2 hours after lunch and dinner. baseline data including constant score (cs), subjective shoulder value (ssv) and numerical rating scale (nrs) for pain were collected. patients were treated with subacromial injection with 40mg of methylprednisolone acetate and 2ml of lidocaine. at discharge, patients were asked to re-measured glycemia for the following week.


Eligibility criteria:
inclusion criteria: * consent to participate in the study. * severe overall pain and night pain: numerical rating scale (nrs) for pain\[8\] above or equal to 60/100; the scale was modified from 0-10 to 0-100 (0 = no pain 100 = unbearable pain). * no significant improvement after at least 2 courses of physiotherapy (including direct assistance from a physical therapist with specific exercises, manual therapy, and physical agents in order to reduce inflammation and pain). * clinical signs of subacromial tendinobursitis, with or without signs of rotator cuff tear, defined as positive neer, yocum and hawkins tests\[9-15\]. pain experienced during the execution of these tests needed to reproduce the type of pain that patients complained the most. * no indication for surgery due to the age, concomitant comorbidities or patient's refusal to undergo surgery. * well-controlled type-2 diabetes, defined as: * fasting and pre-prandial blood glucose levels in the range of 90- 150mg/dl. * hb1ac \<64mmol/mol (corresponding to 8%) measured within 6 months. * a device for self-measurement of blood sugar levels at home * patients need to have a recent (within 6 months) x-ray and an mri or ultrasound of the affected shoulder exclusion criteria: * corticosteroid treatment in the past 3 months. * complaints of shoulder stiffness more than shoulder pain. * symptomatic glenohumeral arthritis defined as shoulder stiffness plus moderate radiographic signs of arthritis (grade \>2 according to hamada classification and grade \>1 according to samilson-prieto classification for eccentric and concentric arthritis respectively). * shoulder trauma within 3 months of inclusion evaluation for in this study. * high blood pressure values (systolic blood pressure \>140mmhg, diastolic blood pressure \>80mmhg). * glaucoma.

Keywords: shoulder pain type 2 diabetes subacromial corticosteroid injection glycemia efficacy safety
effect of washing with clove extract on inflammation and infection place logging shaldon needle

Conditions: Renal Failure

Summary: this randomized clinical trial will conducted involving 60 patients under hemodialysis and hospitalized to imam reza and montasareyeh hospitals of mashhad in 2016. patients were assigned to experimental and control groups of 30 people, randomly (double block). in the both intervention and control group, first will be washed the catheter with betadine, but in intervention group, after 2 minutes will be used of the clove extract with 2 ml of scrub for 15 seconds. the incidence and severity of inflammation as well as infection of vascular access will be assessed in patients on hemodialysis for each patient before starting the process over a period of 2 weeks is equivalent to 6 sessions of hemodialysis.

this study is a randomized clinical trial that will conducted on 60 patients under hemodialysis and hospitalized to imam reza and montasareyeh hospitals of mashhad in 2016. patients were assigned to experimental and control groups of 30 people, randomly (double block). in the both intervention and control group, first will be washed the shaldon catheter with betadine, but in intervention group, after 2 minutes will be used of the clove extract with 2 ml of scrub for 15 seconds. the incidence and severity of inflammation as well as infection of vascular access will be assessed in patients on hemodialysis for each patient before starting the process over a period of 2 weeks is equivalent to 6 sessions of hemodialysis.

Eligibility criteria:
inclusion criteria: * age between 18-80 exclusion criteria: * lack of cooperation patient to participate in the post test

Keywords: inflammation, infection
international cross-sectional and longitudinal assessment on asthma control (liaison)

Conditions: Asthma

Summary: the study design consists of a cross-sectional survey on the clinical characteristics of patients with asthma and their level of asthma control and current quality of life, and on a prospective evaluation of the rate of switch from the uncontrolled/poorly controlled condition to the status of controlled asthma. asthma control will be based on the asthma control questionnaire scoring system, that has been fully validated for use in both clinical practice and clinical trials and has strong discriminative properties which means that it can detect small differences between patients with different levels of asthma control and it is very sensitive to within-patient change in asthma control over time. quality of life as a reflection of the control of the disease, will also be evaluated by means of the mini asthma quality of life questionnaire scoring system.


Eligibility criteria:
inclusion criteria: * inclusion criteria: 1. written informed consent obtained. 2. male or female adult (at least 18 years of age) patients with asthma diagnosed (according to gina guidelines and confirmed by a chest physician) for at least 6 months. 3. patients in treatment with the same antiasthmatic drugs in the last 4 weeks before enrolment. * exclusion criteria: 1. patients enrolled in clinical trial in the previous 4 weeks or subjects already admitted in this study. 2. patients suffering from conditions and illnesses that might interfere with the study purpose, according to the investigator's evaluation.