Kornimate/medical-research-clean huggingface dataset:
the effects of neuroscience-based exercise

Conditions: Chronic Neck Pain; Persistent Neck Pain; Neuroscience Approach

Summary: the aim of this study is to examine the effects of neuroscience-based exercise approaches on pain, disability and gait parameters in individuals with non-specific chronic neck pain. material- methods demographic data, gait parameters, dizabilty level and craniovertebral angle values of individuals were evaluated with clinical data evaluation form, spatio-temporal gait analysis (legsystm), neck disability index and photometer, respectively. the evaluations were performed 2 times before and after the treatment.

neuroscience-based exercise approaches are a promising method that has been introduced in recent years in the treatment of non-specific musculoskeletal pain and related dysfunctions. the basis of this method is the exercises and trainings created by considering the neurobiological (changes in tissues) and neurophysiological basis (brain fog, somatosensory sensitization) of nociplastic pain in the musculoskeletal system. in the neuroscience-based exercise approach, it is aimed to reduce the increase in sensitivity in brain fog and somatosensory pathways. the main purpose is to teach the cortex that movement can be done painlessly and accurately and to alleviate the symptoms in the related tissues. it is aimed to perform the exercise painlessly and accurately by adding cognitive goals and changing the focus (14). in the literature, although there are very few studies showing that neuroscience education and therapeutic exercise combinations are effective on chronic nociplastic pain in patients with non-specific chronic neck pain, no studies examining the effects of neuroscience-based exercise approaches on gait parameters in individuals with non-specific chronic neck pain were found (15). ,16). our study will contribute to the literature in this field and will reveal the effects of neuroscience-based exercise approaches more clearly. the aim of this study is to examine the effects of neuroscience-based exercise approaches on pain, disability and gait parameters in individuals with non-specific chronic neck pain. material- methods demographic data, gait parameters, dizabilty level and craniovertebral angle values of individuals were evaluated with clinical data evaluation form, spatio-temporal gait analysis (legsystm), neck disability index and photometer, respectively. the evaluations were performed 2 times before and after the treatment.

Eligibility criteria:
inclusion criteria: * diagnosing with chronic non-specific neck pain * volunteer to participate in the study * beetwen 18-25 years old exclusion criteria: * have had any cervical area surgery * having any disease that would affect the assessments

Keywords: neuroscience based exercises chronic neck pain gait parameters
effectiveness of immobilization in the postoperative analgesia of surgically treated distal radius fractures

Conditions: Radius Fracture Distal

Summary: the purpose of this study is to determine wether postoperative immobilization is effective in controlling the pain of patients with intra-articular distal radius fractures treated with volar locking plate fixation. the study hypotheses is that postoperative immobilization does not enhance the analgesia of these patients.

volar locking plate fixation has been used as the gold standard treatment for intra-articular distal radius fractures. the need for postoperative immobilization after this type of fixation is controversial, with some authors advocating its use for analgesia. conversely, the use of immobilization might retard the recovery of wrist range of motion and function. the objective of this study is to compare the level of pain and function of patients undergoing surgical fixation of distal radius fractures using or not postoperative immobilization. patients will be randomly assigned to receive a plaster splint or conventional dressing immediately after the surgery. the main outcome is the level of pain in the first two weeks postoperatively.

Eligibility criteria:
inclusion criteria: * intra-articular distal radius fracture treated with volar locking plate fixation; * fracture occurred within the prior 30 days; * consent to participate in the study exclusion criteria: * concomitant fracture of the ipsilateral upper limb * previous lesion of the ipsilateral upper limb with functional deficit * bilateral fracture * concomitant neurologic injury * patient not amenable to follow-up

Keywords: distal radius fracture volar plate immobilization
qeq treatment responsiveness evaluation study

Conditions: Impotence

Summary: the quality of erection questionnaire (qeq) is a new questionnaire that was developed to assess erectile attributes in men with erectile dysfunction. the study objective is to validate the quality of erection questionnaire (qeq) through the evaluation of subject responses to the qeq regarding the quality and hardness of erections at baseline compared to subject responses post 6 and 10 weeks dosing with viagra (sildenafil citrate).


Eligibility criteria:
inclusion criteria: * subjects must have documented clinical diagnosis of erectile dysfunction based on a screening shi-m score of \<21 and the subject fulfilling the nih definition of erectile dysfunction * subjects must be either pde-5 inhibitor naive; i.e. have never used sildenafil, tadalafil or vardenafil, or have been previously treated with no more than six doses of a pde-5 inhibitor (sildenafil, tadalafil, vardenafil) and must have taken their last dose no less than 4 weeks prior to the screening visit exclusion criteria: * subjects who are currently prescribed, taking and/or likely to be treated with nitrates or nitric oxide donors in any form on either a regular or intermittent basis
cardiometabolic hiit-rt study

Conditions: Metabolic Diseases; Overweight; Motor Activity

Summary: several studies have shown relationship between exercise intensity and improvement cardiometabolic health such as body composition, endothelial function, blood pressure and blood lipids. it has been suggested that high intensity interval training and also strength or resistance training generate positive effects on metabolic risk factors, nevertheless the comparison between both types of training and their combination has not yet provided conclusive evidence. also, it has been shown that dietary restriction has similar or more positive effects that exercise alone and the effect is greater when it is combined with exercise. for these reasons, it is necessary to clarify which type of training, in combination with a dietary restriction, is more effective to improve cardiometabolic health

the investigators hypothesized that high intensity interval, resistance training or combined training would result in similar improvements in cardiometabolic health as compared to the usual clinical care in a cohort of sedentary overweight (age 30-50 years old).

Eligibility criteria:
inclusion criteria: * meets at least one criteria for metabolic syndrome (idf 2006): central obesity: waist circumference ≥90cm (men) ≥80cm (women); triglycerides ≥ 150mg/dl; hdl-c \<40mg/dl (men) \<50 (women); blood pressure ≥130/85mmhg and fasting plasma glucose ≥ 100mg/dl. * written informed consent. * interested in improving health and fitness. exclusion criteria: * systemic infections. * weight loss or gain of \>10% of body weight in the past 6 months for any reason. * currently taking medication that suppresses or stimulates appetite. * uncontrolled hypertension: systolic blood pressure 160 mm hg or diastolic blood pressure 95 mm hg on treatment. * gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy). * asthma. * diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dl), or use of any anti-diabetic medications. * currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months). * any active use of illegal or illicit drugs. * current exerciser (\>30 min organized exercise per week). * indication of unsuitability of current health for exercise protocol (parq). * any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.
dyspnea and cardiotoxicity in multiple myeloma patients who receive carfilzomib

Conditions: Multiple Myeloma; Shortness of Breath; Dyspnea; Cardiotoxicity

Summary: this study will explore why some multiple myeloma patients who receive carfilzomib (an anti-cancer medication) experience shortness of breath while others do not. the purpose of this research is to gather information on the effectiveness of the endopat device, which is fda-approved to assess the health of a patient's blood vessels. these assessments will help doctors leading the study determine the reasons why patients may develop shortness of breath (dyspnea) when being treated with carfilzomib and ways to better prevent this shortness of breath.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * confirmed diagnosis of multiple myeloma * newly-diagnosed multiple myeloma, or relapsed/refractory multiple myeloma with receipt of 1-3 previous lines of therapy and with a 2-week washout from prior therapy * receiving carfilzomib as either standard-of-care therapy or as part of a clinical trial exclusion criteria: * previous receipt of anthracycline chemotherapy * previous receipt of carfilzomib * four or more previous lines of therapy * active pregnancy at the time of enrollment

Keywords: multiple myeloma
effects of virtual reality mri preparedness

Conditions: Anxiety; Educational Problems

Summary: magnetic resonance imaging is an important and increasingly prevalent imaging modality used in healthcare. children often find the procedure anxiety provoking causing difficulty in staying still and providing quality images. the use of preparation techniques including play therapy and role play utilizing such tools as a fiberglass mock mri have shown to reduce anxiety and facilitate better image quality. modalities of preparation including virtual reality (vr) pose as an alternative to habituate children for a mri procedure.


Eligibility criteria:
inclusion criteria: * child is between the ages of 8-9 years inclusive * child scheduled for a clinical mri at chla. exclusion criteria: * child is younger than 8 years or older than 9 years. these are the bottom end of age ranges that are frequently sedated. * children who have metal in their bodies that cannot participant in an mri. * medical history that may affect brain development that may confound ability to complete an mri without sedation. * children suffering from epilepsy or history of seizures who may react poorly to a virtual reality intervention. * child who has a history of mri acquisition where habituation and preparedness may not be needed. * child with english as a second language due to restrictions of research team. * child with implantable medical devices or personal medical devices that may be affected by the study device's radio waves

Keywords: virtual reality magnetic resonance imaging radiology
effects of virtual reality on perioperative pediatric anxiety

Conditions: Preoperative Anxiety; Maladaptive Postoperative Behavior; Emergence Delirium

Summary: this study evaluates the effect of virtual reality on anxiety levels in a pediatric surgical population. half of participants will receive standard perioperative treatment, while the other half will receive additionally a virtual reality local program.

it is well known that there is a high incidence of significant anxiety in pediatric population perioperatively, with adverse side effects in terms of emergence delirium and maladaptive postoperative behaviors. many different strategies have been designed in order to minimize these negative consequences. virtual reality is a new and simple technology that can be used at young ages. the aim of this study is to measure anxiety levels at different times in children scheduled for ambulatory surgery compared to patients with standard care without virtual reality.

Eligibility criteria:
inclusion criteria: * child between 4 and 12 years old * elective ambulatory surgery * parents posses a smart phone * child and parents understand spanish or catalan * patient information has been explained * informed consent is signed * surgery scheduled in the morning exclusion criteria: * child has hearing impairment * child has visual impairment * child has previous experience of anesthesia * american society os anesthesiologists (asa) score of iii or greater * children with history of seizures * children under psychiatric treatment

Keywords: virtual reality pediatric surgery
a comparative study on the effect of propolis and dentine bonding agent in treating dentine hypersensitivity

Conditions: Dentine Hypersensitivity

Summary: background: dentine hypersensitivity (dh) causes considerable pain and discomfort to an individual due to number of stimuli on exposed dentine. different kinds of treatment strategies are used in the resolution of dentine hypersensitivity including the use of propolis and dentine bonding agent. no study had compared the efficacy of propolis and dentine bonding agent. objective: the objective of the study was to find out whether there is a difference in the efficacy of propolis and seventh generation dentine bonding agent in reducing the dentine hypersensitivity. comparison within the groups and pairwise comparisons were also recorded in reducing dentine hypersensitivity. methods: in this six month in- vivo single blinded randomized clinical study, a total number of 52 patients with complain of dentine hypersensitivity were selected in two groups after taking informed consent. group a and b received 30% ethanolic extract of propolis and dentine bonding agents respectively by a trained operator. recordings of dentine hypersensitivity were obtained at day 0, before and after the application of experimental agents, and also on day 7, 15 and 30 by the principal investigator. response was measured by visual analog scale and schiff cold air sensitivity scale. statistical package for the social sciences (spss) version 20 was used to analyze the data with level of significance set at p \< 0.05. friedman test was applied to see the comparison within groups and wilcoxon signed rank test was used for pairwise comparison. mann whitney u-test was applied for comparison between groups.


Eligibility criteria:
inclusion criteria: * outpatients reporting to periodontology department of dow international dental college (didc) with dentine hypersensitivity * patients having age of 20- 45 years * systemically healthy patients * patients having at least 2 vital teeth with hypersensitivity * patients having sensitivity on facial surfaces to air stimulus * patients with score i of silness and loe plaque index 77 * patients who used fluoride dentifrices for hypersensitivity but could not get relief from it. exclusion criteria: * patients with carious, cracked or restored teeth, abutment teeth used of removable or fixed prosthesis and tooth with any other dental pathology * patients who used analgesics, mood alteration drugs during last six months * smoker, pregnant and nursing mothers * patients who used tooth whitening or bleaching agents in the last six months * patients who were undergoing orthodontic therapy and history of periodontal surgery during last six months
online vs. face-to-face nutritional advice in kuwait (eatwellq8)

Conditions: Dietary Modification; Dietary Habits

Summary: the eatwellq8 study aims to investigate the effectiveness of a mobile web application (e-nutri), capable of delivering automated personalised nutrition advice, compared with face-to-face nutritional advice, in increasing diet quality. dietary assessment is via the validated food4me ffq (with an updated user interface that has been designed for better usability) and dietary feedback is derived according to adherence to an 11-item modified us alternative healthy eating index (m-ahei).


Eligibility criteria:
inclusion criteria: * aged \> 21 years exclusion criteria: * aged \< 21 years old * not living in the uk * pregnant/lactating * no or limited access to internet * following a prescribed diet for any reason * intolerance or food allergy * subject with diabetes, or any other metabolic disorder or illness that alters nutritional requirements

Keywords: personalised nutrition mobile web application
factors associated with cpc 1-2 in 110 patients admitted in french icu for a myocardial infarction complicated by an ohca.

Conditions: Out-Of-Hospital Cardiac Arrest; Myocardial Infarction; Coma; Outcome, Fatal; Neurologic Dysfunction

Summary: this study evaluate the association of some in-icu factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.

pre-hospital factors associated with poor neurologic outcome are well known. meanwhile, in-icu factors for the first 24 hours may impact neurologic outcome. this observational study aim to study the factors such as ecls, nse dosage, therapeutic hypotermia... and their association with neurologic outcome in patient with myocardial infarction due to instable coronaropathy complicated by an out-of-+hospital cardiac arrest. this is designed to be a observationnal, prospective, multicentric national french study

Eligibility criteria:
inclusion criteria: * aged of 18 years old or more * non opposition of the patient, or his family if he is unable to consent, after loyal and comprehensive explanation * patient admitted in icu * the reason for admission is a resurected out-of-hospital cardiac arrest * the cause of the cardiac arrest is a type 1 myocardial infarction exclusion criteria: * refractory cardiac arrest (no flow \> 30 minutes in normothermia) * in-hospital cardiac arrest * pregnancy * patient under juridic protection * opposition of the patient, or of his family is he is unable to consent.
atopic dermatitis cutaneous discomfort of the infant under the age of one year : analysis of filmed sequences (pre-prurineo)

Conditions: Atopic Dermatitis

Summary: analysis of filmed sequences for the assessment of discomfort in atopic dermatitis in infants under 1year of age

atopic dermatitis (ad) is a chronic inflammatory and itchy dermatitis particularly common in childhood since it affects about 20% of the pediatric population, with revelation usually around the age of 3-6 months of life. however, there are very few pediatric population data on the prevalence of pruritus and associated discomfort in infants. although the skin and the nervous system of the infant (\<6 months) are competent in the experiment of the pruritus, the acquisition of an intentional motricity allowing the targeted scratching of the affected body areas is done only from the age of 6 months, making it difficult to diagnose the intensity of the ad and assess the potential discomfort caused. currently, the diagnosis and assessment of pruritus in children is based on a hetero-rating through scales, which are not at all applicable for infants under 6 months of age (population concerned by our study). the visual scale numeric rating scale, validated in adult population seems to be the one that most accurately assesses the severity of pruritus. in pediatric populations, the use of the eppendorf itch questionnaire and the us version of the childhood atopic dermatitis impact scale are recommended. alternatives to the clinical and subjective rating of the severity of pruritus have been described via actigraphy: thus, a strong statistical correlation has been demonstrated between a nocturnal measurement of wrist motor activity as a reflection of the intensity of pruritus, and the analysis of videos filmed in infra-red. but, again, the technique is not suitable for young infants, because of the absence of voluntary motivated motor skills, and because of less organized sleep / wake cycles. in order to better manage infants less than 1 year old, the analysis of their behavior in case of atopic dermatitis seems necessary to us to better identify a potential discomfort in these patients. this is an essential preliminary study that will allow us to better define the judgment criteria necessary for the implementation of an observational study comparing infants with atopic dermatitis to healthy infants.

Eligibility criteria:
inclusion criteria: * infants under 1 year old * with atopic dermatitis * no opposition from at least one of the patient's parents exclusion criteria: * acute intercurrent pathology * severe malformation or genetic abnomalies * parent (s) minor (s) or unfit (s) to give their informed consent * refusal of patients

Keywords: atopic dermatitis infant etology
posture, hand functions and sensory processing skills on nutrition

Conditions: Autism Spectrum Disorder; Autism; Autism, Mild; ASD

Summary: to examine the effects of posture, hand functions and sensory processing skills on nutrition in children with autism spectrum disorder. the study aims to include 40 children diagnosed with autism spectrum disorder (asd), directed from the department of child and adolescent psychiatry at istanbul university, along with their parents/caregivers, and 40 healthy children along with their parents/caregivers.

parents/caregivers of children diagnosed with asd will be assessed using a demographic information form; sensory processing (dunn sensory profile); nutrition (screening tool for eating problems (step), brief autism mealtime behavior inventory (bambi)); quality of life (pediatric quality of life inventory (pedsql 4.0)); children will undergo assessments for balance (pediatric berg balance scale); head posture (craniovertebral angle method), hand functions (jebsen taylor hand function test); grip strength (jamar hand dynamometer); and parents' evaluations for depression, anxiety, and stress levels (beck depression inventory, beck anxiety inventory, spielberger state-trait anxiety inventory). the assessment duration, including explanations and questionnaires, will take approximately 1 hour.

Eligibility criteria:
inclusion criteria: * age between 5-10 years, * diagnosis of autism spectrum disorder (asd), * children scoring between 30-36.5 points on the childhood autism rating scale (cars), * absence of any oral structural disorders, * willingness of the parent to voluntarily participate in the study. exclusion criteria: * absence of physical, visual, and auditory impairments other than autism spectrum disorder (asd). * presence of any additional neurological, genetic, or metabolic disorders.

Keywords: autism spectrum disorder posture sensory processing hand functions nutrition