Kornimate/medical-research-clean huggingface dataset:
whole body vibration and pelvic floor exercises on urinary incontinence

Conditions: Urinary Incontinence

Summary: stress urinary incontinence is common in men following prostate cancer surgery. rehabilitative interventions incorporate pelvic floor muscle training, biofeedback, electrical stimulation, lifestyle changes, or a combination of these strategies. however, little is known about the physiological impact of whole-body vibration for stress urinary incontinence following radical prostatectomy. participants: sixty-one patients with mild stress urinary incontinence after radical prostatectomy. intervention: patients were randomly assigned into two groups: group 1 included 30 patients who received pelvic floor muscle training and whole-body vibration training with a frequency and amplitude of 20 hz/ 2 mm for the first 2 sessions and 40 hz/ 4 mm for the rest of intervention; while group 2 included 31 patients who performed only pelvic floor muscle training. the intervention in both groups was performed three times per week for 4 weeks.

participants were recruited from cairo university hospitals who suffered from mild sui for at least 6 months after rp. the diagnosis was confirmed by the referred physician via 24-h pad test which supposed to be less than 100 grams gain of weight of the pad/s worn by the patient. the exclusion criteria were artificial pacemaker, body mass index (bmi)\> 35 kg/m2, urinary infection, bleeding from the urinary bladder or the digestive tract, polyuria, diabetes mellitus, detrusor over-activity, neuromuscular disorder, ear problems or any other medical condition that would affect participation in the training program. main outcomes: incontinence visual analogue scale (i-vas), the international consultation on incontinence questionnaire-urinary incontinence-short form (iciq-ui-sf) and 24-hour pad test.

Eligibility criteria:
inclusion criteria: * the initial sample was adult patients suffering from urinary incontinence at least 6 months after radical prostatectomy. exclusion criteria: * the exclusion criteria included patients with an artificial pacemaker, body mass index more than 35 kg/ m2, urinary infection, bleeding from the urinary bladder or the digestive tract, polyuria, diabetes mellitus, detrusor instability, neuromuscular disorders, and any other medical condition that affects participation in the training program.

Keywords: whole body vibration, pelvic floor muscle
effects of a single oral dose of ketone ester on exercise performance in patients with chronic heart failure

Conditions: Heart Failure With Reduced Ejection Fraction; Heart Failure

Summary: in a randomized, double-blind, placebo-controlled cross-over design, subjects will either receive a supplemental drink containing a commercially available ketone ester (deltag®, 500 mg/kg body weight), or a taste matched, isovolumic placebodrink and will then perform the 31phosphorus magnetic resonance spectroscopy (31p mrs) exercise protocol. after 1-2 weeks, subjects will cross-over and repeat the 31p mrs exercise protocol, this time receiving the other treatment.

the goal of this study is to investigate if oral ketone supplementation stimulates mitochondrial atp production and improves exercise performance in patients with chronic hf. in a randomized, double-blind, placebo-controlled cross-over design, subjects will either receive a supplemental drink containing a commercially available ketone ester (deltag®, 500 mg/kg body weight), or a taste matched, isovolumic placebodrink and will then perform the 31p mrs exercise protocol. after 1-2 weeks, subjects will cross-over and repeat the 31p mrs exercise protocol, this time receiving the other treatment. endpoints include rate and magnitude of change in phosphocreatine (pcr) and inorganic phosphate (pi) concentrations from baseline to maximum exercise, rate and magnitude of change in pcr and pi concentrations during recovery, rates and magnitude of change in intramuscular ph during exercise and recovery, maximal exercise performance and change in concentrations of beta-hydroxybutyrate and other metabolites before consumption of the supplemental drink, after consumption of the supplemental drink and after exercise.

Eligibility criteria:
inclusion criteria: * chronic heart failure nyha ii - iii * lvef ≤40% * stable for the last 1 month prior to the study exclusion criteria: * age \<18 years; * unable or unwilling to undergo exercise mri (physical disabilities, claustrophobia); * unable to complete the exercise protocol during the screening visit according to the professional opinion of the investigators; * comorbidities which can influence study results such as muscular dystrophies, peripheral artery disease, diabetes mellitus, severe anaemia (defined as hb ≤6 mmol/l); * pregnant/trying to get pregnant/breastfeeding during the period from the first exercise test until 4 weeks after the last exercise test); * absolute contra-indications to undergo mri according to the current umcg protocols and guidelines (e.g. non-conditional medical device, recent device implantation, incompatible ferromagnetic objects in the body). * bmi \ 35 kg/m2 * unable to understand study procedures; * unable or unwilling to provide informed consent.

Keywords: heart failure ketone body hfref skeletal muscle metabolism mitochondrial ketone oxidation 31p mrs pi/pcr
research on optimization and evaluation of oral cancer screening methods

Conditions: Oral Cancer

Summary: an evaluation and validation study on oral cancer screening methods will be carried out, and two different methods will be used for oral cancer screening among the population. the two different methods are: (1) clinical observation (including inspection and palpation) combined with pathological biopsy. (2) clinical observation (including inspection and palpation), in vivo staining (toluidine blue) combined with pathological biopsy. by evaluating and comparing the sensitivity and specificity of the two screening methods, the more effective oral cancer screening method will be selected.

an evaluation and validation study on oral cancer screening methods will be carried out, and two different methods will be used for oral cancer screening among the population. the two different methods are: (1) clinical observation (including inspection and palpation) combined with pathological biopsy. that is, inspecting and palpating the oral cavity and neck of the screened object. if positive lesions are found, then further pathological biopsy will be performed. this is also the commonly used screening method for oral cancer now; (2) clinical observation (including inspection and palpation), in vivo staining (toluidine blue) combined with pathological biopsy. that is, toluidine blue staining is performed at the same time as the inspection and palpation of the oral cavity and neck of the screening object. as long as the screening subjects found positive lesions or abnormal living body staining, pathological biopsy was performed. by evaluating and comparing the sensitivity and specificity of the two screening methods, the more effective oral cancer screening method will be selected. finally, we will carry out prospective controlled population studies in high-risk areas and non-high-risk areas to further evaluate the effectiveness and feasibility of screening method after selection.

Eligibility criteria:
inclusion criteria: * aged 40-69 years old. exclusion criteria: * no.

Keywords: oral cancer screening method
a pilot prospective clinical trial using remote monitoring for cancer patients undergoing outpatient chemotherapy

Conditions: Solid Tumor; Hematological Malignancy

Summary: a pilot study using remote monitoring technology developed by locus health in cancer patients undergoing chemotherapy treatment.

modern-day wearable devices, such as apple watches or fitbits, are widely available, non-invasive, and can provide continuous vital sign monitoring for the early detection of potential health complications. early detection of things such as fever or increased heart rate can alert patients to seek medical attention sooner and therefore have the potential to improve patient outcomes and decrease healthcare costs. to further investigate the feasibility of using remote patient monitoring ( rpm)to prospectively monitor patients undergoing outpatient chemotherapy for chemotherapy related toxicities, defined as follows: (1) patients answer queries through the locus health iphone app at least 70% of the time; (2) patients report that the locus health iphone app and the apple watch were 'easy to use,' defined as an average score of 7 or higher on the first two questions of the post-intervention questionnaire, and (3) fewer than 10% of patients withdraw from the study.

Eligibility criteria:
inclusion criteria: * planned to be treated with a new cytotoxic chemotherapy or chemoimmunotherapy regimen for a solid tumor or malignant hematology condition for at least 4 months * ecog performance status of 0-2 * age of 18 or older patient with any solid tumor or hematologic malignancy * english or spanish speaker * own an apple iphone * capacity and willingness to provide informed consent exclusion criteria: * patients undergoing concurrent radiation since they will be seen on a daily basis by clinic care teams and are not likely to benefit from active remote patient monitoring * patients unwilling or unable to comply with the protocol, including wearing the apple watch (including recharging daily) and answering queries on the locus health iphone application per the protocol and study group cadence * any condition for which in the investigator's opinion would limit compliance with study requirements

Keywords: wearable electronic devices
p3: pacemaker patient profiling study

Conditions: Bradycardia

Summary: the p3 study is a united states post market study to gather data on clinical status, primary indications, device therapy choices, clinical management and outcomes for patients with implantable pacemakers.


Eligibility criteria:
inclusion criteria: * patient meets class i / class ii indications for pacing * patient implanted with one of the following market-approved single or dual chamber medtronic devices: enrhythm™, enpulse®, kappa® 700, kappa® 900, vitatron clarity™, vitatron selection® afm, vitatron c-series, vitatron t-series, or the at500™ dddr pacing system exclusion criteria: * patient is enrolled in a device or cardiovascular drug study that affects treatment and/or study device programming * patient whose life expectancy is less than two years

Keywords: pacemaker bradycardia
the efficacy and safety of the fuzuloparib combination with bevacizumab

Conditions: Recurrent Ovarian Cancer

Summary: the study will be a prospective, single-arm, phase ⅱ clinical study. this study intends to explore the efficacy and safety of fuzuloparib combined with bevacizumab in the maintenance treatment of patients with platinum-sensitive ovarian cancer. the progression-free survival, os, and safety were evaluated based on recist v1.1.

due to the lack of effective predictive molecular markers in the maintenance treatment phase, it is difficult to assess the effectiveness of maintenance treatment. this project plans to collect blood and urine from subjects before maintenance treatment, during relapse, and for follow-up molecular marker exploration research.

Eligibility criteria:
inclusion criteria: 1. patients with platinum-sensitive recurrent ovarian cancer confirmed by pathology or histology; 2. patients who have previously received platinum-based chemotherapy and had a recurrence interval of \> 6 months before the last platinum-based chemotherapy; 3. patients who have previously received bevacizumab and did not experience progression within 3 months during the use of bevacizumab; 4. patients who have previously received parp inhibitors and did not experience progression within 12 months during the use of parp inhibitors; 5. the patient achieved a complete or partial response after the last platinum-based chemotherapy; 6. eastern cooperative oncology group (ecog) performance status of 0-1; 7. the patient has a life expectancy of at least 3 months and sufficient organ function; 8. the patient has sufficient bone marrow reserves and organ function, including a creatinine clearance rate of 45 ml/min calculated using the standard cockcroft and gault formula; 9. the patient voluntarily agrees to participate in this study and signs an informed consent form. exclusion criteria: 1. patients who are known to be allergic or intolerant to chemotherapy drugs or their excipients and cannot swallow medication; 2. patients who have undergone major surgery within 28 days prior to enrollment; 3. patients with central nervous system metastases or a history of seizures within the past 12 months; 4. uncontrolled hypertension: systolic blood pressure ≥180mmhg, diastolic blood pressure ≥90mmhg; 5. nyha functional class ≥ iii; 6. patients with severe, uncontrolled systemic diseases; 7. patients who have received any other investigational drug treatment or participated in any other clinical trials within 30 days prior to enrollment in this study; 8. pregnant or lactating patients, or patients who cannot guarantee effective contraception during the study treatment period; 9. patients with poorly controlled neurological or psychiatric disorders or mental illness, poor compliance, and inability to cooperate or describe treatment response; 10. patients judged by the investigator to be unsuitable for participation in this study.
comprehensive program for youth mental health

Conditions: Depression; Suicide; Anxiety

Summary: the majority of addiction and mental health problems seen in adults present first in youth. there is strong evidence that prevention and early identification during childhood can mitigate some of these risks. students who screen at risk for the development of mental illness will be offered online intervention programs with personal guidance from a trained coach. in addition, lessons revolving around resiliency will be provided to all students. the objectives of this study are: * decreased rates of depression and suicide (as well as rates of suicide attempts) * decreased use of alcohol, tobacco, and other drugs, with additional downstream benefits such as reduced rates of fetal alcohol spectrum disorder (fasd) and cancer * decreased school drop-out rates decreased rates of interactions with the justice system * decreased costs across a range of ministries (health, education, justice, human services), both for youth as well as their families who have been involved in this program


Eligibility criteria:
inclusion criteria: * the intervention group will be the top 10% of all students participating in the school screening. exclusion criteria: * lack of consent, lack of assent, lack of the ability to read and understand the screening tools or intervention tools
cardiovascular epidemiology in russian federation

Conditions: Hypertension; Coronary Artery Disease; Diabetes; Heart Failure; Smoking; Lifestyle

Summary: the study addresses epidemiology of cardiovascular risk factors and major cardiovascular diseases in russian federation (urban and rural population). 12 regions of 1600 participants in each will be included.

plasma lipids and fasting glucose, heart rate and blood pressure, anthropometry, smoking and alcohol questionaries, nutrition, sleep quality, stress will be assessed. ecg records are obtained form all participants. subclinical target organ damage (carotid and periferal atherosclerosis, pulse wave velocity) will be measured in selected sites. brain natriuretic peptide, adipose tissue cytokines, hscrp and genetic markers are also under evaluation

Eligibility criteria:
inclusion criteria: - informed consent exclusion criteria: no

Keywords: hypertension epidemiology glucose body mass index lipids smoking coronary artery disease arterial stiffness carotid ultrasound
anodal transcranial direct current stimulation on mobility and balance in post stroke patients.

Conditions: Stroke

Summary: to determine the effects of anodal transcranial direct current stimulation on mobility and balance in post stroke patients.

stroke is characterised as sudden onset of neurological dysfunction of central anxious framework that contain cerebral infarction, intra cranial haemorrhage \& subarachnoid haemorrhage. around the globe stroke is the chief cause of incapacity and passing. the trans-cranial direct current stimulations (tdcs) could be a non-invasive,low cost and capable brain stimulator utilised within the treatment of brain disorders.two modes of tdcs is utilised is stroke patients,anodal stimulation (increased in excitability) of the lesional half of the globe and cathodal stimulation (decreased in excitability) of the contralesional hemisphere. the transcranial direct current stimulation induced polarity-dependent changes in membrane excitability, with anodal-tdcs causing depolarisation and cathodal-tdcs causing hyper polarization of membrane potential in neurons of the stimulated area. the role of trans-cranial direct current stimulation as a catalyst of recovery in stroke population and found that it's a safe,portable,non invasive brain stimulation technique. t-dcs is able to modulate the excitability of specified brain areas by varying the neuronal membrane potentials that based on the polarity of the current transmitted through the scalp via sponge electrodes. trans-cranial direct current stimulation is clinically potential for use in stroke recovery because of its ease of use, non invasive-ness and safety.

Eligibility criteria:
inclusion criteria: * patients presenting with both ischemic and hemorrhagic stroke * subacute and chronic stroke patients(onset of stroke from 3 months to 1 year) * ambulatory stroke survivors were included who met the criteria of modified rankin scale between 1 and 3 exclusion criteria: * patients with modified rankin scale of 0 and 4-6. * brain tumors * cognitive impaired * known case of seizures * metal implant, head injury etc and other disorders which contraindicate the application of anodal transcranial direct current stimulations.

Keywords: balance stroke anodal transcranial direct current stimulation
role of healthy bacteria in ulcerative colitis

Conditions: Ulcerative Colitis

Summary: intestinal inflammation seen in inflammatory bowel disease (ibd) results from an altered mucosal immune response to luminal bacterial antigens. current research suggests that an inappropriate and persistent immune response against commensal intestinal bacterial flora plays a pivotal role in the pathogenesis of chronic inflammatory bowel disease (ibd). it has been also proposed that the signs and symptoms of ibd may be mediated by the increased intestinal permeability secondary to low grade inflammation in the gut mucosa. increased intestinal permeability results in further exposure of underlying intestinal mucosa to luminal bacteria and antigens perpetuating the intestinal inflammation. thus restoring intestinal permeability rather than only reduction of mucosal inflammation would thus be a desirable endpoint in the restoration of mucosal integrity and would be the harbinger of better long term outcome. many clinical trials have shown that probiotics may have beneficial effect on ibd patients. probiotics are hypothesized to work by several mechanisms though they are not clearly established. the role of probiotics in improving intestinal permeability has not been evaluated. the probiotic vsl #3 is easily available, cheap, effective and safe alternative or substitute for the existing therapeutic agents will be evaluated in this study for their efficacy, tolerability, compliance in inducing clinical response in patients with ulcerative colitis. this will be a double blind randomized placebo controlled study to determine the clinical efficacy of 12 weeks of oral probiotics (vsl#3) in patients with inflammatory bowel disease. the objectives of this study are to determine the efficacy of probiotics on clinical endoscopic and histological improvement, to find the improvement in faecal, serum and intestinal tissue inflammatory markers, improvement in intestinal permeability, improvement in quality of life parameters.


Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * active disease at presentation exclusion criteria: * pregnant or lactating women * any patient who has received probiotic in the preceding 4 weeks * patient with life threatening cardiac, renal, pulmonary or cardiovascular disease * inability to obtain the informed consent * severe disease requiring hospitalization / steroids/ anti-cytokine therapy * patient taking aspirin and other antiplatelet drugs * patient with uncontrolled diabetes * patient with gall stone disease * patient currently on antibiotic,nsaids or indigenous medicine

Keywords: probiotics ulcerative colitis inflammatory bowel disease
alpha-lipoic acid combined with b vitamins shows promise for treating restless legs syndrome

Conditions: Restless Legs Syndrome

Summary: investigating tiobec® 400's efficacy in alleviating restless legs syndrome symptoms sheds light on promising therapeutic avenues.

restless legs syndrome, also known as willis-ekbom disease, is a neurological disorder characterised by uncomfortable sensations in the legs and an urge to move them. in spain, its prevalence range is estimated to be between 11.6% - 19.5% in adults, but it is difficult to know due to underdiagnosis. alpha-lipoic acid (ala) and b vitamins have emerged as potential treatments due to their roles in reducing oxidative stress and associated vitamin deficiencies. the tiobec® 400 (t400) supplement combines ala, b vitamins, e, and c, and its efficacy and safety in alleviating rls symptoms, along with its impact on anthropometric measures, are under investigation. this study aims to explore therapeutic options for managing rls, with promising results.

Eligibility criteria:
inclusion criteria: * participants must be a minimum of 18 years of age. * they must have a primary diagnosis of rls without prior therapeutic interventions for the ailment. * they need to provide explicit consent via an informed consent document. exclusion criteria: * patients diagnosed with pathologies other than rls that affect sleep quality. * those with persistent renal diseases or any other chronic, severe medical condition.

Keywords: rls