Kornimate/medical-research-clean huggingface dataset:
impact of preoperative dental screening in reducing infective endocarditis risk in surgical valve replacement patients

Conditions: Surgical Valve Replacement; Dental; Endocarditis

Summary: in odense university hospital preoperative dental screening (pds) protocol for patients treated with surgical valve replacement was changed from mandatory to targeted pds to from march 2024. the investigators will therefore compare the risk of ie before vs after march 2024.

infective endocarditis (ie), a condition linked with significant mortality and morbidity rates, is particularly concerning for patients with prosthetic left-sided valves. these patients face an elevated ie risk, estimated at about 1% annually in tertiary care settings, cumulatively impacting around one in every 20 patients over a decade. in line with this, both the american heart association (aha) and the european society of cardiology (esc) strongly advocate for the elimination of potential dental sepsis sources at least two weeks before prosthetic valve implantation, except in urgent cases. these guidelines, while not grounded in randomized trials, largely draw upon registry data detailing ie incidence among surgical valve replacement patients. in a recent study the investigators found no difference in risk of ie when comparing mandatory preoperative dental screening (mpds) with no preoperative dental screening (npds). thus, this prospective registry-based observational before-and-after study aims to investigate the impact of different preoperative dental screening practices on the risk of ie in patients undergoing.

Eligibility criteria:
inclusion criteria: * patients undergoing surgical valve replacement exclusion criteria: * none
eeg@home (phase 4 of the project)

Conditions: Epilepsy

Summary: the goal of this project is the development of an eeg-cap (min. 21 electrodes) with user-friendly active dry electrodes that meets the expectations of the users regarding comfort and esthetics, without losing sight of the functional and technical demands for recording high quality eeg signals. the purpose is to use the eeg-cap to investigate clinical neurological disorders (e.g. epilepsy). the eeg-cap could also be used at home so that hospital admission in the emu can be avoided for some patients and an increasing number of patients can be examined. in this stage of the project video-eeg recording with the prototype will be compared to the conventional way (cup-electrodes and collodion) of recording in the emu. minimum 1 - maximum 10 patients with prominent ieds will be included. after the conventional recording is completed, the patient will undergo a recording of maximum 5 hours with the prototype. there will be an visual and clinical evaluation of the eeg-signals (blinded) and a technical evaluation of the eeg-signals. user experience and experience of the eeg-technologists will also be collected.


Eligibility criteria:
inclusion criteria: * epilepsy with on eeg prominent ieds exclusion criteria: * /
post-pandemic perception of public space in singapore

Conditions: Stress; Anxiety

Summary: in this study it is aimed to investigate the difference between the brain response to different urban environments in singapore before and after the covid-19 pandemic. the datasets acquired from 34 healthy individuals as part of ongoing study "effects of landscape on the brain" (irb ref #: s-18-352) will be used. these datasets consist of neurophysiological data recordings and behavioral self-reported measures and were collected before 20 of january 2020. the same experimental protocol would be followed, given that the data collection in the lab-setting would start after 7 th may 2020/whenever research activities are allowed to resume, and the outdoor sessions after the "circuit-breaker" period in singapore is over.

the aim is to explore the difference between pre and post covid-19-related isolation on their perception of green and public spaces, as well as mood, neuroelectrical (eeg) and haemodynamic (fnirs) response. the hypothesi is that crowded, busy public spaces, such as experimental site near chinatown mrt, may induce more patterns of brain activity related to stress, anxiety and aversive attitudes after covid-19 as compared to before. similarily, it is expected that green urban spaces, such as experimental site at hortpark, perceived after covid-19 can elicit more salutogenic effect of relaxation, positive emotions and attention restoration than before the pandemic. this study will allow better understanding of the mental health consequences of unprecedented period of isolation at home and social distancing. the relationship between city residents and their living environment may change due to covid-19 and it's very important to uncover the mental health implications of social distancing to prepare for potential future outbreaks through developing tools and solutions addressing specific issues. finally, for the urban planning and design the study may highlight important trends in changing human perception of space and redefine the concept of a "healthy city".

Eligibility criteria:
inclusion criteria: * age of 21 to 75 * right-handed only exclusion criteria: * left-handed * serious visual or auditory impairment * major neurological disorders e.g. epilepsy, stroke * any form of cancer * major heart diseases: e.g. ischemic heart disease * major lung diseases: e.g. chronic obstructive pulmonary disorder. * major liver disease e.g. liver failure * major kidney disease e.g. kidney failure

Keywords: landscape exposure eeg fnirs stress urban self-isolation covid-19 pandemic public space brain
ala and prostate cancer

Conditions: Atrial Fibrillation; Diet Therapy; Prostate Cancer

Summary: the problem is the lack of data from randomized controlled trials to throw light on the ala-prostate cancer issue. there is therefore a need to acquire evidence from a randomized controlled study to illustrate the effect of ala on a surrogate marker for prostate cancer, namely prostate specific antigen (psa). demonstration that atrial fibrillation recurrence was reduced after cardioversion and that there was no adverse effect of 1 years of ala feeding on psa would go a considerable way to providing the required evidence that ala in the human diet has no adverse effect on the prostate and so allow its use for cardiovascular risk reduction. hypothesis: the effect of ala on psa levels over time will be no different from the control, so providing supportive data for the view that ala is not cancer promoting.

in addition disturbing news on alpha-linolenic acid (ala) has recently been reviewed by brouwer and colleagues (j nutr:2004). their analyses suggests that ala, as found in canola oil and other healthy foods, may cause prostate cancer even though there is good evidence that canola oil will prevent heart disease. this issue urgently needs further research. in studies largely from the harvard group, but suggested by additional studies from uruguay and spain, a link has been identified between ala intake and prostate cancer. the harvard studies are cohort studies where groups of approximately 40,000 doctors or health professionals have been followed up for periods of 10 years and the dietary intakes of ala related to the subsequent development of aggressive prostate cancer. it must be stressed that these are not randomized crossover studies which are the currently accepted gold standard for evidence-based medicine and regulatory decision making. nevertheless they raise concern over the health profile of a fatty acid with a growing reputation for cardiovascular disease prevention and a component of other healthy foods such as walnuts, flax, canola and soy. the same harvard group identified the deleterious effects on cardiovascular health of trans fatty acids in their cohort studies and this has resulted in a major effort to remove trans fatty acids from the food supply. on the other hand their identification of the benefits of vitamin e in their cohort studies has not been confirmed by subsequent randomized controlled trials. although dr willett, the senior member of the harvard group, has drawn surprisingly little attention to the negative findings with ala, it remains a sticking point with regulators in the current debate over the inclusion and use of ala in the food supply. this concern has been sufficient for the natural health products directorate of health canada to ask for a full proposal from us before we start studies on ala in the prevention of atrial fibrillation due the apparently negative impact of ala consumption on prostate cancer.

Eligibility criteria:
inclusion criteria: * blood samples available from bordeaux exclusion criteria: * blood samples not received from bordeaux
safety and efficacy of abicipar pegol in participants with neovascular age-related macular degeneration

Conditions: Macular Degeneration

Summary: this is a safety and efficacy study of abicipar pegol in participants with neovascular age-related macular degeneration.


Eligibility criteria:
inclusion criteria: * diagnosis of age-related macular degeneration in at least 1 eye * best corrected visual acuity of 20/40 to 20/320 in the study eye * best corrected visual acuity of 20/200 or better in the non-study eye exclusion criteria: * history of vitrectomy, macular surgery, or glaucoma surgery in the study eye * cataract or refractive surgery in the study eye within the last 3 months
the immunogenicity of simultaneous administration of quadrivalent influenza vaccine and 23-valent pneumococcal vaccine

Conditions: Pneumococcal Pneumonia; Influenza

Summary: the immunogenicity of simultaneous administration of quadrivalent influenza vaccine and pneumococcal vaccine was unknown. the purpose of present study is to compare the immunogenicity of simultaneous administration of influenza vaccine and pneumococcal vaccine with that of separate administration.

the immunogenicity of simultaneous administration of quadrivalent influenza vaccine and pneumococcal vaccine was unknown. we compare the immunogenicity of simultaneous administration of quadrivalent influenza vaccine and pneumococcal vaccine with that of separate administration. 162 participants are randomly assigned to one of the two study groups; simultaneous administration group: receive injections of pneumococcal vaccine and influenza vaccine simultaneously. sequential administration group: receive injections of pneumococcal vaccine 2 weeks after the injection of the influenza vaccine. we compare the immunogenicity of the two groups.

Eligibility criteria:
inclusion criteria: * adults aged ≧65 years who had never received pneumococcal vaccine and quadrivalent influenza vaccine of 2015/2016 season exclusion criteria: * a sensitivity to pneumococcal and influenza vaccine * received other inactivated vaccine within 14 days * received other live vaccine within 28 days * the presence of conditions known to impair pneumococcal vaccine response * having malignant disease * taking oral corticosteroids or immunosuppressive agent * history of splenectomy * history of an acute febrile illness or signs of severe acute illness at the time of vaccination * other inappropriate condition to receive vaccination * suffering an acute illness requiring antibiotics or steroids within the past month * not expected to survive 12 months were also excluded

Keywords: quadrivalent influenza vaccine 23-valent pneumococcal vaccine immunogenicity
comparison of bpap st/t and bpap st / t mode with avaps for hypercapnic respiratory failure in ed

Conditions: Hypercapnic Respiratory Failure

Summary: the aim of the present study; to compare the effects of respiratory support options available for nimv at the emergency department; i.e. avaps and st/t modes, on the patient's pco2 values, additional treatment need (another non-invasive ventilation method or endotracheal intubation) and the duration of stay in hospital.

non-invasive positive pressure ventilation (nimv) is a life-saving procedure for patients with hypoxic and/or hypercapnic respiratory failure. avaps (average volume assured pressure support) is a noninvasive ventilation mode which has been developed to assure volume and pressure controlled respiratory support. avaps can ensure a constant tidal air volume to the patient with variable pressure support. thus the positive features of the volume and pressure controlled support, which have a positive impact on the healing and recovery processes are combined. this study aims to compare, in a randomized order, bpap st/t and bpap st / t mode with avaps, in patients with hypercapnic respiratory failure in the emergency department. subjects: one hundred and two patients with hypercapnic respiratory failure will be included. primary outcome; decrease in the paco2 values secondary outcomes are stated as; failure of treatment options, or change of the nimv mode due to patient noncompliance or the patient's need for intubation and length of hospital stay (length of stay in the hospital from the emergency department).

Eligibility criteria:
inclusion criteria: paco2 \> 45mmhg and any of the following * sao2 \<90% on air * sao2 \ 6 litres o2/min * inability to speak in sentences due to respiratory distress * respiratory rate \> 24/min * altered mental status * the use of accessory muscles of respiration exclusion criteria: * respiratory arrest or unstable cardiorespiratory status * suspected pneumothorax * urgent need for intubation * systolic blood pressure \< 90 mmhg * inability to protect airway * facial deformity * facial, esophageal, or gastric surgery history * all trauma patients * acute myocardial infarction * severe arrythmias * refractory nausea and vomiting

Keywords: respiratory failure, hypercapnia, bpap, avaps
a multi-center prospective randomized controlled study on clinical and radiographic analysis of prodisc-c vivo

Conditions: Disk Degeneration; Cervical Disc Disease

Summary: the object of this study is to assess the long-term safety and efficacy of cervical disc replacement with the prodisc-c vivo cervical disc in a prospective, randomized, multi-center trial with 7 years of follow-up.

this is a prospective, randomized, multicenter trial at 7 years of follow-up comparing prodisc-c vivo artificial cervical disc replacement and acdf (anterior cervical discectomy fusion) to treat degenerative disc disease (ddd). 648 ddd patients (age from 20 to 70) from several hospitals matching the inclusion criteria will be randomly assigned to two groups (324 patients in each group). one group will be treated with prodisc-c vivo disc replacement. the other group will be treated with acdf. the clinical outcomes and radiographic measurements will be compared between two groups at 1.5, 3, 6, 12, 24, 36, 60, and 84 months after the surgical treatments.

Eligibility criteria:
inclusion criteria: * single-level cervical disc disease. * at least one additional confirmatory neuroradiographic study, such as mri or ct- enhanced myelography that showed findings consistent with clinical findings and complaints. exclusion criteria: * patients have cervical spinal conditions other than single-level symptomatic degenerative disc disease or evidence of instability. * symptomatic disc disease at level c2 -3 or c7-t1. * a history of discitis. * a medical condition that required medication,such as steroids or nonsteroidal antiinflammatory medications that could interfere with fusion.

Keywords: prodisc-c vivo acdf cervical degenerative disc disease
safety, tolerability and pharmacokinetics of csl360 in the treatment of acute myeloid leukemia

Conditions: Acute Myeloid Leukemia (AML)

Summary: acute myeloid leukemia (aml) is a heterogeneous group of diseases characterized by uncontrolled proliferation of the myeloid line of white blood cells and impaired production of normal blood cells. if untreated, patients die of infection or bleeding usually in a matter of weeks. csl360 is a neutralising monoclonal antibody which is believed to target the cells that are thought to drive aml but that are not effectively killed by standard treatment. the aims of the study are to determine a biologically active dose of csl360 and generate understanding of a rational schedule of administration for future studies.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute myeloid leukemia * recent bone marrow biopsy * prior treatment or medically unfit for standard therapy exclusion criteria: * peripheral blood blast count \> 30 x 109/l, or rapidly progressive aml * previous solid organ transplant * active gvhd or immunosuppression * concurrent treatment with other anti-cancer therapy * active infections
laparoscopic sacropexy: comparison of mesh attachment

Conditions: Vaginal Vault Prolapse

Summary: the purpose of this study is to compare postoperative complications and outcome two different attachment sites of the dorsal mesh support in laparoscopic sacropexy.

laparoscopic sacropexy has become a well established treatment option for vaginal vault prolapse with excellent outcome and low rates of recurrence. compared to the similar vaginal sacropexy procedure a significant rate of postoperative constipation is reported. as the surgical technique is very similar for both procedures it could be possible that the exposure of the lower vaginal wall and placement and of the dorsal mesh and closer proximity to the colon in laparoscopic sacropexy might cause this. in this randomized controlled clinical trial we compare two different attachment sites for the dorsal mesh during laparoscopic sacropexy. one group is randomized for attachment in the middle of the dorsal wall of the vaginal stump and for the other group preparation and attachment for the dorsal mesh is performed deeper in the lower pelvis for an attachment at the distal part of the dorsal vaginal wall. peri-operative data, intra- and postoperative complications and results of short-term (constipation) and long-term( recurrences rate) outcome are recorded.

Eligibility criteria:
inclusion criteria: * vaginal vault prolapse * recurrence of vaginal vault prolapse * signed consent exclusion criteria: * rectocele * bmi\>40

Keywords: vaginal vault prolapse laparoscopic sacropexy
feeding regulation in sci

Conditions: Spinal Cord Injuries

Summary: the overall purpose of this research is to understand the reasons why persons with spinal cord injuries eat more calories than they need to "burn", stay alive, and function. this research will investigate how quickly food moves through a participant's body, the hormones in the participant's body that control energy and digestion, and a participant's impressions of hunger after eating a meal. this will be compared in persons with and without a spinal cord injury.


Eligibility criteria:
inclusion criteria: spinal cord injury (sci) participants: 1. adults (≥ 18 years) with tetraplegia (c5-c8) or paraplegia (t1-l2) sci 2. chronic sci, denoted as ≥ 12 months post-injury 3. american spinal injury association impairment scale164 a, b, and c 4. persons with tetraplegia self-report they are able to feed themselves 5. self-report on a bowel care program every-other-day 6. english speaking control group (healthy) participants: 1. adults (≥ 18 years) without a sci (will be sex- and age-matched to persons with sci) 2. english speaking exclusion criteria: for all participants: 1. currently on a weight loss program/diet and/or actively trying to lose weight 2. have a self-reported history of * diabetes * thyroid disease * gastrointestinal disease * previous abdominal surgery ≤ 3 months prior to the study * peripheral nervous system prosthesis * swallowing disorders 3. self-reported food allergies to or dislike the test meals. 4. self-reported use of a prokinetic agent, antipsychotic agent, or glucagon like peptide 1 (glp-1) agonists 5. individuals who are not yet adults (infants, children, teenagers) 6. women that self-report they are pregnant or likely to become pregnant 7. prisoners

Keywords: gut eating appetite hormone
insufflation in children undergoing colonoscopy

Conditions: Colonoscopy; Children

Summary: studies in adults have shown that post-procedural abdominal pain is reduced with the use of co2 instead of air for insufflation during colonoscopy. the aim of our study is to compare post-procedural abdominal pain and girth in children undergoing colonoscopy using co2 or air for insufflation.

several prospective studies in adults have confirmed the efficacy and safety of co2 insufflation in comparison with atmospheric air insufflation during colonoscopy. co2 insufflation was associated with decreased post-procedural abdominal pain, which likely stems from the fact that, in comparison to air, absorption of co2 from the colon is much faster due to a much greater water solubility. animal studies have also shown that co2 insufflation results in less disturbance of parietal blood flow due to its potential vasodilating effect. insufflation of colon with co2 did not prolong the procedure or lengthen the time to reach the terminal ileum and was proven to be safe in both sedated and non-sedated patients . the use of co2 for colon insufflation could possibly lead to co2 retention and increased levels in the blood thus interfering with acid-base balance . however, previous studies reported that carbon dioxide insufflation did not cause increased co2 levels in the blood or end-tidal co2 (etco2) and complication rates were not increased when using co2. because of its advantages co2 insufflation has become a standard of care in adult colonoscopy. to the best of our knowledge there are so far no published reports comparing co2 and air insufflation during colonoscopy in children.

Eligibility criteria:
inclusion criteria: * indication for colonoscopy exclusion criteria: * pm retardation * postprocedural complications regarding sedation

Keywords: insufflation abdominal pain