Kornimate/medical-research-clean huggingface dataset:
ultrasound guided ureteroscopy and ureteric stones

Conditions: Ureteric Stone

Summary: the prevalence of urolithiasis is steadily increasing with an estimation of 1 out of 11 people in the united states. the prevalence of calculi in afro-asian region including arab republic of egypt ranges from 4% to 20%. ureteroscopy is one of the first line treatments for definitive management of ureteric stones. conventional ureteroscopy relies on intraoperative fluoroscopy for visualization and guidance, exposing the patient, surgeon and operating room staff to ionizing radiation. to minimize the hazards of ionizing radiation there has been a trend toward radiation free alternative imaging modalities . ultrasound provides an excellent alternative for upper urinary tract imaging because it is radiation free, rapid, portable and allows excellent visualization of the renal pelvis and calyces. there is increasing awareness and concern about the clinical use of ionizing radiation and the need to decrease exposure of patients and medical professionals. ultrasound guided ureteroscopy in pregnant females and children- in whom fluoroscopy is to be minimized or avoided when possible - has been reported.


Eligibility criteria:
inclusion criteria: 1. patients with single symptomatic lower third ureteric radio-opaque stones indicated for endoscopic treatment. 2. age group 18 years old or above. 3. stone size 15 mm or less. exclusion criteria: 1. patients with bilateral ureteric stones 2. ureteric congenital anomalies e.g. double ureter and ectopic ureter. 3. previously failed ureteroscopy or previous ureteroneocystostomy.
perioperative goal directed therapy (pgdt) in spinal surgery in the prone position

Conditions: Intraoperative Hypotension; Pulmonary Complication; Cardiovascular Complication

Summary: this study aims at evaluating if a specific protocol, that can be framed in the innovative concept of perioperative goal directed therapy (pgdt), based on the evaluation of the stroke volume variation (svv) - a parameter deriving from the adoption of a minimally invasive advanced hemodynamic monitoring technology with a special sensor called flotrac® (edwards) or of a non-invasive monitoring system with the clearsight® sensor (edwards) - is able to guarantee a greater precision in the intraoperative management of patients undergoing spinal surgery in prone position.


Eligibility criteria:
inclusion criteria: * age between 18-80 years * american society of anesthesiologists(asa) classification i-ii-iii * minor and major spinal surgery * prone position * sinus rhythm * absence of atrial fibrillation. or severe arrhythmia * informed consent exclusion criteria: * absence of informed consent * age less than 18 or older than 80 years * cardiac rhythm abnormalities: atrial fibrillation and / or severe arrhythmia

Keywords: spinal surgery
using conversation maps to reinforce self-care

Conditions: Type 2 Diabetes

Summary: many people with type 2 diabetes are not able to keep their blood glucose in good control. improving blood glucose control and maintaining that improvement is important for diabetes patients because doing so delays the onset and progression of severe complications of diabetes. although educational programs may be helpful, their effect is not always long-lasting. this project is studying whether the conversation maps program (an interactive diabetes education program) reinforces diabetes education and information and thus helps type 2 diabetes patients take better care of their diabetes and blood glucose levels. half of the patients will attend the conversation maps program and half of the patients will attend an educational program about blood pressure and cholesterol. also, all patients will come in for 4 or 5 appointments to complete surveys and other tests and have their blood drawn. the group of patients who attend the conversation maps program will be compared to the group of patients who attend the blood pressure and cholesterol program to see if the educational programs helped diabetes patients to improve their diabetes control and quality of life and to maintain that improvement over time.


Eligibility criteria:
inclusion criteria: * ages 25-75 years * diagnosis of type 2 diabetes mellitus * two a1c levels ≥7.0 % (above ada target) * 2 years since initial diagnosis. this will provide a minimum of two-years experience with diabetes treatment. also, excluding those who are newly diagnosed will prevent improvement due to newly prescribed medications from confounding study results. * attended one of joslin's group education programs or comparable 3-hour (or more) educational programs and/or appointments exclusion criteria: * severe complications of diabetes including renal disease (microalbumin \>300 ug/mg), severe peripheral diabetic neuropathy and/or severe peripheral vascular disease, symptomatic severe autonomic neuropathy, that may place participants at risk when increasing activity levels. * proliferative diabetic retinopathy based on dilated eye examination within one year of study entry. patients whose eye disease is successfully treated will be included. * current or planned pregnancy * a1c levels less than 7.0% (normal range 4.0 - 6.0%) and a1c levels greater than 14%. * a history of severe, unstable myocardial infarction, congestive heart failure or other severe cardiac disease, or severe hypertension (systolic ≥160 mmhg or diastolic ≥ 90 mmhg) (increased risk when mildly increasing physical activity). * a diagnosis of bipolar disorder, schizophrenia, mental retardation, organic mental disorder, and alcohol or drug abuse will be excluded, as well as patients currently undergoing psychiatric treatment. these exclusions are being made to avoid confounds due to concurrent changes in mental status and the effects of ongoing psychiatric treatment. * used conversation maps as an educational tool * started a new diabetes medication (pills or insulin) in past three months

Keywords: diabetes education
monitoring medication adherence in left ventricular assist device recipients

Conditions: Heart Failure; Medication Compliance

Summary: the investigators aim to develop a novel and wireless method for monitoring medication adherence among heart failure patients with left ventricular assist devices (lvads). proteus digital™ has developed an ingestible and bio-absorbable micro-sensor as a strategy to monitor medication compliance. the edible sensor has at its core a silicon-based integrated circuit measuring 1.0 mm x 0.45 mm and is imbedded on a pill. once ingested, this circuit is activated by gastric acid resulting in an electrochemical redox reaction and an electrical charge that is transmitted to a patch worn over the abdomen and wirelessly to a portable device such as a smart phone. this strategy of medication adherence differs from conventional adherence monitoring including pill counting and patient-recall by precisely tracking medication ingestion.

the objectives are to assess the efficacy and safety of the proteus digital™ micro-sensor in an exploratory investigation among heart failure patients with lvads. medication adherence, specifically to anticoagulation is critically important in the post-implant period to maintain lvad function and to decrease thromboembolic complications; however, commonly results in significant bleeding resulting in significant morbidity and mortality. in addition, the anticipated degree of anticoagulation is unpredictable after lvad implantation due to factors related to changes in hepatic blood flow and endothelial dysfunction. enrolling 10 patients will provide results into the function of micro-sensor and to provide a preliminary assessment of sensor-based activity, signal strength and signal duration in lvad recipients. participants will be enrolled during an in-patient hospitalization to assess the efficacy and safety of the device in a monitored setting.

Eligibility criteria:
inclusion criteria: - patients undergoing lvad implantation for end-stage heart failure or admitted from the out-patient setting exclusion criteria: * unable to consistently consume oral intake * hemodynamic instability defined as hypotension requiring intravenous vasoactive medications or arrhythmias requiring intravenous antiarrhythmics or oral antiarrhythmics for rhythm stabilization * gastrointestinal bleeding requiring intravenous gastric acid secretion inhibitors

Keywords: telemedicine mobile health
the impact of a dietary fiber enriched diet on the outcome of patients with liver cirrhosis

Conditions: Liver Cirrhosis

Summary: the goal of this dietary intervention is to study the impact of a dietary fiber enriched diet on the intestinal dysbiosis, systemic inflammation and cirrhosis-related complications in patients with liver cirrhosis. therefore, our aim is to investigate the impact of a dietary fiber enriched diet on * frailty and sarcopenia * systemic inflammation * microbiome composition * quality of life and the composition of patients diet. participants receive a dietary counselling and will be asked to increase their dietary fiber intake. as malnutrition is a common complication in cirrhosis and patients with advanced liver disease often show a disability to meet their daily food-requirements, the recommended intake of 30 gram dietary fibers per day is unlikely in this group of patients. therefore, the fiber-enriched diet will be supplemented by the physiological short-chain-fatty-acid propionate, as a fiber-surrogate.

the disease course of liver cirrhosis is associated with a progressing dysbiosis of the intestinal microbiome and systemic inflammation, that leads to the development of cirrhosis-associated immune dysfunction (caid). in healthy individuals, the microbiome uses orally incorporated dietary fibers for the production of short-chain-fatty-acids (scfa). one of these physiological short-chain-fatty acids is propionate. scfa´s are essential for a maintained integrity of the intestinal barrier and promote anti-inflammatory effects. due to a reduction of symbiotic gut bacteria and an elevated number of potentially pathogenic microbes in cirrhosis, diminished levels of scfa can be observed in this group of patients. consequently, the permeability of the gut barrier increases and a bacterial translocation results. this translocation is a main driver of systemic inflammation and is linked to a higher likelihood for infections, such as spontaneous bacterial peritonitis (sbp). furthermore, systemic inflammation promotes the degradation of skeleton muscles (sarcopenia) and frailty. both are associated with a poor prognosis in cirrhosis. however, the impact of an adapted diet, that intends to normalize the intestinal scfa-levels, on the clinical outcome of patients with advanced liver disease, needs to be further evaluated. therefore, the included patients receive dietary counseling, supplemented with propionate, that functions as fiber-surrogate. the dietary-intervention will last for a period of two months.

Eligibility criteria:
inclusion criteria: * patients of legal age and with the ability to give informed consent * patients with liver cirrhosis and portal hypertension exclusion criteria: * patients with transjugular intrahepatic portosystemic shunt (tips) * significant immunosuppression * malignant tumor * underage
a study of exercise therapy in people with solid tumor cancer

Conditions: Solid Tumor Cancer

Summary: the purpose of this study is to find out whether exercise therapy is an effective and safe treatment that causes few or mild side effects when done before standard surgery for solid tumor cancer. the researchers will also study whether the program is feasible (practical) by tracking how well participants follow the program.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed (on preoperative biopsy), resectable, treatment naïve cancer of one of the following types: head and neck, lung, renal, liver, colorectal, gastric, ovarian, melanoma, pancreas, or breast cancer. * age ≥18 years. * an interval of ≥3 weeks until planned surgical resection; surgery will not be delayed to accommodate the minimum length of exercise therapy intervention in any circumstance. * measurable disease based on standard of care radiology scans or confirmation by the surgeon. * body weight ≤ 385 lbs (≤ 174 kg) * non-exercisers, defined as ≤60 minutes of moderate or vigorous exercise/week based on self-report using a validated survey. * cleared for moderate-intensity exercise therapy using the physical activity readiness questionnaire (par-q)+ with screening clearance provided at the discretion of the pi/exercise physiologist. * willingness to comply with all study-related procedures exclusion criteria: * distant metastases. * receiving any form of antitumor therapy. * enrollment onto any other interventional investigational study except interventions determined by the pi not to confound the effect of exercise on study outcomes. * any other diagnosis of invasive cancer currently requiring active treatment. * any other condition (e.g., pregnancy) or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation.

Keywords: exercise therapy 24-232
a study investigating an exercise and education programme for individuals with ankylosing spondylitis

Conditions: Spondylitis, Ankylosing

Summary: ankylosing spondylitis(as) is a chronic, inflammatory, rheumatic disease (khan, 2002). as is associated with increased work disability and use of healthcare resources (ward et al, 2008). evidence suggests that group exercise is the most effective form of physiotherapy management for individuals with ankylosing spondylitis (dagfinrud et al, 2008). to date, no research has been published in relation to short, intensive group exercise programmes. this study aims to investigate the effects of a five day exercise and education programme for individuals with ankylosing spondylitis. effects of the programme on disease activity, function and spinal mobility will be measured using using validated quantitative measures; the overall value of the programme for patients will be explored by means of semi-structured interviews.

patients with a diagnosis of ankylosing spondylitis are referred to the 5-day exercise and education programme by consultant rheumatologists at the mater misericordiae university hospital. all patients referred to the programmes beginning 06/24/2008 and 08/25/2008 will be invited to participate. participants scoring 0-6 on the bath ankylosing spondylitis metrology index are classified as low disease severity level and are allocated to group 1; participants with a score of 6.1-10 are classified as higher disease severity and allocated to group 2. group 1 has two hydrotherapy classes, a gym-based exercise class and an education session daily. group 2 has one hydrotherapy class, a gym-based exercise class and an education session daily. exercise sessions are 1 hour in duration and are given by staff physiotherapists. education sessions are 1 hour in duration and are given by senior members of the rheumatology multi-disciplinary team at the mater misericordiae university hospital. outcome will be assessed upon entry to the study (pre-intervention), at 5 days (post-intervention) and at 4 weeks (follow-up). a semi structured interview will be carried out with each participant immediately post-intervention to explore the overall value of the group programme for participants.

Eligibility criteria:
inclusion criteria: * a diagnosis of ankylosing spondylitis according to the modified new york criteria exclusion criteria: * patients for whom hydrotherapy or land-exercise have been contra-indicated * cognitive impairment * patients unwilling to give informed, written consent

Keywords: exercise education hydrotherapy physical therapy modalities
early resistance training post valve replacement surgery

Conditions: Valve Disease, Heart

Summary: background: recent recommendations from the european society of cardiology (esc) are multidisciplinary cardiac rehabilitation including therapeutic exercises for patients after heart valve surgery unless there is insufficient evidence to decide whether therapeutic exercise cardiac training should be provided for such patients. as well, resistance training is an extremely safe systemic physical activity, and it has no contraindications if well-oriented, in addition to being the fastest-growing physical activity in the world in several practitioner settings. purpose: this study was conducted to investigate the effect of early resistance training on the fitness level (vo2 max) and (pr interval) of patients post-valve replacement surgery.

method: forty males post-valve replacement surgery participants' age ranged from 20 to 30 years old and were selected randomly from national heart institute (imbaba), this study was conducted in the period between april and november 2022, and those participants were allocated randomly into two equal groups twenty in each group. group a received aerobic and resistance training three sessions per week for one-month, and group b received aerobic training three sessions per week for one month. all demographic data was recorded and an ecg device was used to record hr and r-p intervals, six-minute walk test (6mwt) was used to assess of cardiorespiratory fitness for all participants in both groups (a\&b)

Eligibility criteria:
inclusion criteria: 1. participants' age ranged from 20 to 30 years old, 2. participants medically stable to do early resistance exercise in the first week after the operation. 3. each participant had undergone valve replacement surgeries only, 4. participants be able to do early resistance exercises in the first week after the operation. exclusion criteria: * the study excluded the participant if has one or more of the following criteria: * sternal infection and delay sternal healing. * patient with a musculoskeletal condition limiting the ability to exercise or a geographical residence and/or lack of access to transportation, thus preventing exercise session attendance. * the patient has an lv thrombus diagnosed by echocardiography, left ventriculogram, or other imaging. * the patient is known to have unprotected left main coronary artery disease (cad) greater than 50%. * patients have poor cognitive capabilities or poor mentality. * patient who had valve and cabg surgery.

Keywords: post valve replacement resistance exercise aerobic exercise
working memory training in college students with attention-deficit hyperactivity disorder/learning disabilities

Conditions: Attention Deficit Disorder

Summary: the overall objective of the current study is to determine whether computerized working memory (wm) training will enhance wm capacity in college students with attention deficit hyperactivity disorder (adhd)/learning disabilities (ld). there are also three additional objectives. the first is to determine whether improvements in wm will generalize to secondary outcome tasks, such as inhibitory control and planning. the second objective is to examine whether wm training will also ameliorate adhd symptoms of inattention and hyperactivity. the last objective is to investigate whether improvements will be maintained at a two month follow-up period. it is expected that the computerized wm training program will enhance wm capacity in college students with adhd. in addition, it is believed that these increases in wm capacity will also lead to improvements in other executive functions. it is also hypothesized that wm training will lead to a reduction in adhd symptomology. lastly, these improvements should be maintained at three month follow-up.


Eligibility criteria:
inclusion criteria: * diagnosis of adhd/learning disability * registered as a university student (full or part time) * registered at accessibilities services * taking at least one course exclusion criteria: * on a leave
lncrna-based nomogram to assist childhood asthma diagnosis

Conditions: Childhood Asthma

Summary: asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. the lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. recent studies have found a correlation between long-chain non-coding rna (lncrna) expression and childhood asthma, suggesting that lncrna may be a potential biomarker for asthma diagnosis.

the investigators envision exploring the early diagnosis of asthma by combining lncrna with electronic medical records. in this project, the investigators will combine high-throughput sequencing, asthma case database, electronic medical record and informatics to investigate the feasibility of combining lncrna with electronic medical record for asthma diagnostic model. the expected results will establish the foundation for the diagnosis and treatment of childhood asthma and open up new ideas.

Eligibility criteria:
inclusion criteria: children with recurrent wheezing exclusion criteria: 1. diagnosis of other chronic respiratory disease (e.g. cystic fibrosis, bronchopulmonary dysplasia, etc) 2. immunodeficiency- acquired or congenital 3. neuromuscular disease 4. congenital heart disease
the effects of bright light therapy on adolescent's sleep quality and well-being

Conditions: Sleep Disturbance; Depression; Mood; Circadian Rhythms

Summary: sleep problems are common among adolescents which can have a variety of serious biological, emotional, cognitive and psychological consequences. numerous studies have shown that adolescents who suffer from insufficient sleep and poor sleep quality experience decreased mental well-being which is a growing concern in modern societies. effective interventions that enhance sleep quality among adolescents are lacking. one possible reason for sleep problems among adolescents is disturbance in the body's circadian rhythms. as light is known to be the main coordinating factor in circadian rhythms, light therapy is an auspicious method which aims to entrain the circadian rhythms, thereby enhancing sleep quality and well-being. indeed, bright light therapy (blt) has been shown to be a promising treatment to improve sleep and decrease depressive symptoms among different patient groups. however, blt interventions among healthy adolescents are needed. therefore, the current study will investigate whether blt in classrooms of 16 year old students can improve their sleep quality and well-being. the results from the study can be important as it is the first one to examine whether light intensity in the classroom affects sleep and well-being among adolescents. furthermore, if the hypothesis will be supported, a simple and relatively inexpensive method can be implemented to promote better sleep quality and thus have an extensive effect on adolescents' well-being. aim 1 - assess whether blt will improve sleep quality of adolescents. aim 2 - assess whether blt will decrease depressive symptoms in adolescents. aim 3 - assess whether blt will improve mood in adolescents.


Eligibility criteria:
inclusion criteria: * first-year students at the school where the research takes place. * participants provide written informed consent. * parents or caregivers of participants provide informed consent. * read and write icelandic. exclusion criteria: * not first-year students. * participant or parent does not provide written informed consent. * not capable of reading and writing icelandic.

Keywords: light therapy sleep disturbance adolescents well-being circadian rhythms