Kornimate/medical-research-clean huggingface dataset:
progress pediatric study

Conditions: HIV; Depression

Summary: the purpose of this study is to study the hiv disease progression in hiv-infected thai children.

this is a multicenter, observational cohort study. hiv-infected children from 5 institutions are followed to assess hiv disease progression: 1. bamrasnaradura infectious disease institute,2. faculty of medicine siriraj hospital, mahidol university, 3. chiangrai prachanukroh hospital, 4. sanpatong hospital and 5. hiv-nat, thai red cross aids research center.

Eligibility criteria:
inclusion criteria: 1. age \< 18 years old 2. have confirmed hiv infection (elisa,hiv-dna pcr,hiv-rna pcr) 3. signed consent form exclusion criteria: 1. hospitalization 2. emergency case 3. incomplete medical record

Keywords: hiv related adverse events immunological failure virological failure quality of life depression genotypic resistance
to demonstrate the relative bioavailability of geneva and dista (prozac) 20 mg fluoxetine hydrochloride capsules (pulvules) in healthy adult males under fed and fasted conditions

Conditions: Depression

Summary: to demonstrate the relative bioavailability of geneva and dista (prozac) 20 mg fluoxetine hydrochloride capsules (pulvules) in healthy adult males under fed and fasted conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.
trial to evaluate the safety and immunogenicity of a multivalent pneumococcal vaccine in healthy infants

Conditions: Pneumococcal Infections

Summary: a phase 2, randomized, double-blind trial to evaluate the safety and immunogenicity of a multivalent pneumococcal conjugate vaccine in healthy infants

note: detailed description has not been entered.

Eligibility criteria:
inclusion criteria: * male or female infant born at \>36 weeks of gestation and aged 2 months (42 to 98 days) at the time of consent (the day of birth is considered day of life 1). * healthy infant determined by medical history, physical examination, and clinical judgment to be eligible for the study. exclusion criteria: * previous vaccination with licensed or investigational pneumococcal vaccine. * prior receipt of diphtheria, tetanus, pertussis, or polio vaccines. * previous receipt of \>1 dose of hepatitis b vaccine. * prior hepatitis b vaccine must have been administered at age \<30 days. * major known congenital malformation or serious chronic disorder. receipt of blood/plasma products or immunoglobulins
a prospective study of traumatic eye injuries in the period from january 2022 to june 2022 in sohag university hospitals

Conditions: Eye Injuries

Summary: ocular trauma is one of the main causes of severe ocular morbidity. it represents a serious public health problem and leading cause of visual impairment. it is an important and preventable cause of visual impairment in both developing and developed countries.


Eligibility criteria:
inclusion criteria: * all diagnosed cases of eye trauma, regardless of gender, laterality, duration of presentation and other chronic systemic illness exclusion criteria: * patients with previous history of eye trauma or other pathological condition affecting visual acuity
pec block ii in mammoplasty surgeries

Conditions: Mammaplasty; Anesthesia, Conduction; Analgesia; Analgesia, Patient-Controlled

Summary: breast augmentation surgery is the top cosmetic surgery in usa with more then 300.000 cases performed annually. pain is a common complications of the procedure accompanied of dyspnea and nausea due to the surgical manipulation. several anesthetic techniques were developed with the objective of providing optimal surgical conditions together with enhanced recovery and post-op pain management. pectoralis major block was first described in 2011 by blanco in female patients undergoing oncologic procedures in the anterior thoracic wall. the investigators hypothesized if the pectoralis major block combined with general anesthesia standard techniques could be beneficial in improving pain scores and opioid consumption during post operative period of patients undergoing breast augmentation surgery.

patients undergoing breast augmentation mammoplasty were submitted to laryngeal mask placement after anesthetic induction with fentanyl 3ucg/kg , propofol 2mg/kg and atracurium 0,5mg/kg and surgery was performed under standard surgical practices. before the surgical incision patients were randomized either to receive a bilateral pectoralis major block(pec i and ii) with bupivacaine 0,25% with epinephrine or to receive a placebo block with normal saline 0,9%. after the procedure all patients received a intravenous patient-controlled-analgesia pump device with morphine. pain and opioid consumption were assessed with a pain score assessment tool and assessment of the pump administration dosage history. no nsaids or alpha 2 agonist drugs were administered during or after the procedure. the maintenance of anesthesia was performed with propofol and remifentanil total intravenous anesthesia(tiva) models in a standardized fashion. micromanagement of anesthetic drugs was performed by the assistant anesthesiologist physician.

Eligibility criteria:
inclusion criteria: * female * above 18 years old * elective surgery * american society of anesthesia(asa) class i up to iii exclusion criteria: * pregnancy * acute coronary syndrome * history of arrhythmia * functional class new york heart association(nyha) iii or iv * previous thoracic/breast surgery * history of chronic pain * neuromuscular disease
the effects of topical calcium glycerophosphate on surgical wound healing and residual scarring

Conditions: Wound Healing; Scarring

Summary: the purpose of this study is to determine whether topical application of calcium glycerophosphate will result in superior wound appearance and scar minimization.


Eligibility criteria:
inclusion criteria: * informed consent must be obtained * 45-75 years of age * scheduled for bilateral knee replacement surgery exclusion criteria: * employee or immediate family of either akpharma or employee or immediate family of investigator or site personnel * pregnant or breast feeding known allergy or hypersensitivity to calcium or phosphorus supplements * diagnosed with type i or type ii diabetes mellitus
pregabalin in the prevention of postoperative delirium and pain

Conditions: Delirium; Pain

Summary: the purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves overall pain control.

delirium is a common postoperative complication occurring in up to 73% of patients sometime during their hospital stay. elderly patients undergoing major surgical procedures are at highest risk. while many risk factors for delirium are known, the specific pathophysiology of postoperative delirium remains unclear and is likely multifactorial. the most common inciting agents and events include metabolic causes, medications, blood loss, hypoxemia and pain. pain and its management are intimately related to the likelihood of developing postoperative delirium. as a class, gabapentinoids, such as pregabalin, have proven to reduce postoperative pain and narcotic consumption and therefore may have a role to play in the prevention of postoperative delirium.

Eligibility criteria:
inclusion criteria: * aged 60 years and older * booked for major orthopaedic or vascular procedure * expected length of stay \> 2 days exclusion criteria: * open aaa repair * evar * allergy/sensitivity to pregabalin or gabapentin * use of pregabalin or gabapentin in previous 14 days * severe liver disease * severe renal dysfunction defined as either having creatinine clearance \< 30 ml/min or being dialysis-dependent * seizure disorder * mmse \< 24/30 * inability to speak english or french

Keywords: postoperative perioperative orthopedic surgery vascular surgery gabapentinoid
contralateral isokinetic training on strength and reaching skill

Conditions: Hemiplegic Cerebral Palsy

Summary: the study aimed to ascertain how cross-education affected the activity of the paretic muscles in the upper limb and how that affected function in children with spastic hemiplegia and cerebral palsy. additionally, it sought to determine how unilateral isokinetic resistance training affected children with spastic hemiplegia of the contralateral limb in terms of strength development.


Eligibility criteria:
inclusion criteria: * hemiplegic cp children from both genders with age ranged from five to seven year * had mild to moderate spasticity according to the modified ashworth scale * able to follow verbal instructions * able to stand unassisted and ambulate with abnormal pattern exclusion criteria: * children who had any visual or auditory problems, fixed deformities in upper limb that interfere with fine motor functions, with history of any surgical interference in upper limbs for less than one year, and un-cooperative children were excluded.
efficacy and safety of tf002 in cutaneous mastocytosis

Conditions: Cutaneous Mastocytosis

Summary: the current study will investigate the effects of tf002 on cutaneous mastocytosis or cutaneous involvement of systemic mastocytosis as compared to clobetasol proprionate (positive control) and a general skin care product without active ingredient targeting mastocytosis (negative control) based on clinical effects on darier´s signs and the histological evaluation of mast cell numbers in skin bioptic material.

this is a randomised, double-blind, placebo- and active-controlled study with intra-individual comparison of test areas. the primary study target is to evaluate the safety and efficacy of tf002 for the treatment of cutaneous mastocytosis or systemic mastocytosis with skin involvment. the treatment period of 14 days was adjusted to the maximum recommended treatment period for the comparator dermoxinale®. since there are no approved therapies for this indication a placebo controlled design was chosen. there are some reports about transient treatment effects using high potent steroids like clobetasol in mastocytosis. this triggered the decision to use dermoxinale® as positive control. to validate the clinical scores used in the study, surrogate markers describing the darier´s sign (thermography, volumetric test) will be evaluated optionally.

Eligibility criteria:
inclusion criteria: * chronic stable symptomatic maculopapulous cutaneous mastocytosis or systemic mastocytosis with involvement of the skin and with positive darier's sign * 3 comparable skin lesional areas * otherwise healthy according to physical examination * informed consent signed and dated exclusion criteria: * aggressive systemic mastocytosis * other dermatological diseases at treated skin site * known hypersensitivity to study drugs or their components * mental disorders * drug or alcohol dependency * any other chronic or acute illness requiring systemic treatment which might have any influence on the outcome of the study in the 4 weeks before start of treatment and during the study (investigator's decision). * immunodeficiency including hiv * pregnancy or lactation * participation in another clinical trial within the last 30 days * malignant skin lesions * radiation therapy of target areas excluding uv therapy longer then 4 weeks before start of study treatment * dermal comorbidities within the target areas * any concomitant medication which might influence the study objectives or are known to provoke or aggravate mastocytosis

Keywords: cutaneous mastocytosis topical treatment
effect of acute sleep restriction on responses to hypoxia

Conditions: Sleep Deprivation; Hypoxia

Summary: at altitude, humans are exposed to environmental hypoxia induced by the decrease in barometric pressure. on duty or in training, mountain troops, paratroopers or aircrew are regularly exposed to altitude. the effects of altitude on humans occur gradually from 1500 m and depend on both the duration of exposure and the altitude level. cognitive disorders can occur from 3500 m (threshold of disorders) but there is a very large inter-individual variability. the countermeasure to altitude hypoxia is oxygen but its use is not systematic between 3000 and 4000 m. its use depends on the duration of exposure, without clearly established standards. incapacitating effects on the operational capacity and health of soldiers can therefore occur as early as 3500 m. in operations or during training, altitude exposure is often associated with a significant sleep debt (particularly during night or early morning missions), jet lag or precarious rest conditions in overseas operations. these sleep restrictions promote the degradation of mental performance with effects similar to those observed in hypoxia. the combination of these constraints induces a physiological stress which can favour alterations in mental performance, an increase in incapacity, intolerance to altitude or the occurrence of altitude-related pathologies in military personnel. this could occur in particular in the operational zone around the threshold of disorders (3500 m) where the indication of oxygen is discussed. the objective of this study is to assess the impact of acute sleep restriction on hypoxia tolerance.


Eligibility criteria:
inclusion criteria: * male * healthy * between 18 and 45 * smoking \< 5 cigarettes per day or nicotine-free electronic cigarette * having regular physical activity (between 1 and 4 hours of physical activity per week) * affiliated or entitled to a social security plan * no contraindication to physical exercise * having given their consent exclusion criteria: * female * bmi \> 30 * active medical pathology (cardiological, renal, hepatic, cutaneous, neurological, etc.), * history of active pathology of less than 6 months * significant deviation with the normal values observed during the interrogation, clinical examination or electrocardiogram * having spent time at altitude (\> 3500 m) during the last 3 months * absolute or relative contraindication to a stay at high altitude * medical contraindication to sport practice * skin allergy to modified ethanol or capsaicin * wearing a pacemaker or ferromagnetic implants * poor venous capital * pittsburgh sleep quality index questionnaire \> 5 * usual sleep duration \< 6 hours * not covered by a health insurance plan
efficacy of serious game interventions on hcv education for hiv patients

Conditions: HIV Infections

Summary: hepatitis c transmission has a high rate of infection and re-infection among plwh men who have sex with men (msm), and co-infection increases liver and hiv morbidity. the msm group has a low level of awareness and perception of hepatitis c, and lacks health beliefs and prevention behaviors about hepatitis c. in the absence of hepatitis c cognition and health belief, it should be possible to use the health belief model to intervene and design teaching programs to improve the effectiveness of hepatitis c prevention and treatment. in the past, hepatitis c prevention education mostly focused on people who inject drugs (pwid), and was taught in traditional teaching methods. however, the common cause of hepatitis c infection among drug addicts is the sharing of needles and equipment. education is mainly based on drug harm reduction and prevention education, while the msm group is infected with hepatitis c mainly through risky sexual behaviors. the hepatitis c prevention education of drug addicts is adopted the content is clearly not applicable to the msm population. due to the stigma of plwh's msm in the society, individual cases will be subject to prejudice, discrimination and unfair treatment, and they are worried about being excluded from outsiders. therefore, it is necessary to provide a learning environment with a sense of privacy, security and respect. serious games is an educational game that provides a ubiquitous way of learning, using smartphones as a teaching tool, allowing learners to maintain a sense of privacy. positive outcomes in cognitions, attitudes and behaviours related to health promotion and disease management. in terms of sexually transmitted diseases prevention measures, game content can be formulated for specific ethnic groups, and sensitive topics can be placed in the game. without being exposed to real risks, players can simulate the consequences of various risks and corresponding prevention methods to prevent motivate learners to solve problems and learn motivation, and give clear feedback, thereby increasing the knowledge of hepatitis c, health beliefs and the effectiveness of preventive self-efficacy.


Eligibility criteria:
inclusion criteria: * hiv-infected men who have sex with men aged 20-45 * can communicate in appropriate language and understand the research content * able to use smartphone products exclusion criteria: * unable to fully participate in this study

Keywords: msm hepatitis c health belief patterns serious games
como: cognition study with hiv+ patients (ctnpt 015)

Conditions: HIV - Human Immunodeficiency Virus; Cognitive Symptoms

Summary: the purpose of this study is to contribute evidence towards the potential to improve cognition in hiv+ individuals experiencing cognitive decline through personalized change in antiretroviral (arv) medication. to that end, following a comprehensive evaluation to identify confounding clinical conditions, study participants will undergo a lumbar puncture to: (i) measure viral load (at 2 copies/ml); (ii) identify cerebrospinal fluid (csf) genotype and tropism; and (iii) measure concentration of antiretroviral agents. when indicated from the csf analysis, a personalized change in arv will be implemented. cognition will be measured in all at study entry and 6 months later.


Eligibility criteria:
inclusion criteria: * are 18 years and older * have the capacity to give informed consent as determined by the research nurse * have unexplained cognitive decline (reported either by the patient or an outside informant) * have been on a stable art regimen for \> 6 months * have an undetectable viral load in plasma for at least 6 months (a single blip of ≤ 150 copies/ml will be accepted) * have not had a change in medications that could potentially interfere with cognition in the past 4 months exclusion criteria: * detectable vl in the plasma * past history of dementia * past history of central nervous system opportunistic infection or stroke * current substance abuse ( as per dsm-iv criteria) other than cigarettes * coagulopathy * thrombocytopenia * use of coumadin * intra-cranial hypertension

Keywords: human immunodeficiency virus hiv cognitive symptoms cognitive evaluation neuropsychological testing quality of life anxiety viral load antiretroviral cerebrospinal fluid lumbar puncture magnetic resonance imaging mri
a ring-type wearable device for atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this study investigates diagnostic performance of a ring-type wearable device for detecting atrial fibrillation. this is a prospective cohort registry study began after the date of irb approval and until 31th dec. 2019. the eligible criteria are (1) those who admitted the institution for elective direct-current cardioversion of persistent atrial fibrillation, and (2) aged 19 years or more. the exclusion criteria are (1) those aged less than 19 years, (2) those who are not eligible to perform cardioversion by any reasons. this study aims to recruit 200 participants in total. the participants are required to record photoplethysmographic signals by the ring device in addition to routine procedures of direct-current cardioversion, hence, the study is at minimal risk.

1. study title: diagnostic performance of a ring-type wearable device using deep learning analysis of photoplethysmographic signals for detecting atrial fibrillation. 2. study type: investigator initiated study. 3. study design: prospective observational cohort registry design. 4. sponsor: sky labs, inc., republic of korea. 5. the aim of the study: to evaluate diagnostic performance of a ring-type wearable device for detecting atrial fibrillation. 6. study period: from the date of irb approval to 31th dec. 2019. 7. the size of study population: 200 participants 8. the eligibility criteria: (1) those with persistent atrial fibrillation (2) those who admitted the institution for elective direct-current cardioversion (3) those aged 19 years or more 9. the exclusion criteria: (1) those with other forms of cardiac arrhythmias (2) those aged less than 19 hears (3) those who are not eligible to perform electrical cardioversion 10. procedures of the study 1. a participant is under the routine procedures of direct-current cardioversion. 2. on admission, a participant is given with detailed information of the study. 3. after the informed consent, the only additional procedure due to the study is recording photoplethysmographic signal by wearing a ring-type device. 4. recorded signals are evaluated without encompassing persornal information. 11. financial benefits to the participants: none.

Eligibility criteria:
inclusion criteria: * those with persistent atrial fibrillation * those who admitted for elective direct-current cardioversion * those who aged 19 years or more exclusion criteria: * those who aged less than 19 years * those who had other types of cardiac arrhythmias * those who are not eligible to perform electrical cardioversion

Keywords: atrial fibrillation deep learning diagnosis photoplethysmography wearable electronic devices