Kornimate/medical-research-clean huggingface dataset:
implementing a rehabilitation program in patients recovering from covid-19 infection

Conditions: Rehabilitation

Summary: implementation of a supervised rehabilitation program in patients recovering from covid-19-infection who suffer from limitations and symptoms due to the disease 6 to 8 weeks from hospital discharge. patients who have been seriously ill and have been admitted to the ward with high oxygen mixtures or have been admitted to the icu will be selected primarily. the program includes supervised rehabilitation sessions 2 times a week for 2 months. patients will be evaluated during recruitment and at the end of the program. patients who can not attend the program due to logistical/transport issues will be re-evaluated in 2 months and constitute the control population. investigators hypothesis is that post covid-19 patients who have persistent symptoms, including fatigue following a supervised rehabilitation program will have fewer symptoms after the end of the program compared to similar patients who do not attend a rehabilitation program.


Eligibility criteria:
inclusion criteria: candidates for inclusion in the study are: * patients recovering from covid-19 disease and suffering from persistent limitations (\>=1 month) of their physical activity and reduction of their quality of life and associated symptoms including shortness of breath, fatigue, weakness of the upper and lower extremities, post-traumatic stress, pain, etc. * priority will be given to patients suffering from more symptoms and disabilities. patients who might suffer more after covid-19 disease are: 1. patients admitted to the icu, especially those who were intubated. 2. patients who needed high oxygen mixtures (high-flow nasal cannula -hfnc, non-re-breathing mask) as well as those who were older and had prolonged hospitalization. - exclusion criteria: * patients who suffer from active disease will not be included until they stop being infectious. * patients treated with covid-19 infection where the main reason for hospitalization was not the virus infection (e.g. due to coronary heart disease, surgery, etc.) will also be excluded. * patients suffering from dementia, * patients with myocarditis * patients with thromboembolic disease that receive anticoagulants for less than a month * patients chronically paralyzed, * patients with paraplegia, * patients with multiple injuries * patients with serious orthopedic problems that cause disability * patients suffering from very serious underlying diseases such as end-stage cancer, * patients with neurological diseases that cause disability, require rehabilitation clinics and special interventions (speech therapy, kinesiotherapy, patients with tracheostomy etc.).

Keywords: rehabilitation post covid-19 sequalae
analytical performance of ph, hne and mpo levels in detecting wound infection proof of concept biomarker study

Conditions: Wound Infection; Wound Heal

Summary: the purpose of this study is to evaluate the effectiveness of a novel combination of biomarkers, ph/hne/mpo, in detecting wound infection using the clinical judgement at 4 weeks as a standard of reference which will include a wound biopsy.

one of the biggest challenges in wound care today is the accurate and timely diagnosis of infection in complex wounds. despite efforts, it still remains difficult to determine whether complex wounds are infected or not. there is no single gold standard for wound infection: clinicians use a multitude of methods in addition to the history and their examination to reach an overall conclusion as to potential wound infection status - each with its own strengths and weaknesses (associated performance characteristics). to aid accurate and timely detection of wound infection in clinical practice, convatec and partners have developed a new technology intended to detect infection biomarkers. this is based on the combined measurement of the following three biomarkers: wound ph, and activity of human neutrophil elastase (hne) and myeloperoxidase (mpo) host enzymes. the overall aim of this proof of concept study is to demonstrate that the three infection biomarkers (hne/mpo/ph) surpass clinical judgement in detecting infection status using a standard of reference. the primary objective of the proof of concept study is to demonstrate the effectiveness of a novel combination of biomarkers, ph/hne/mpo, in detecting wound infection using the clinical judgement at 4 weeks as a standard of reference which will include a wound biopsy. the secondary objective of the proof of concept study is to explore the relationship between molecular microbiological analysis of swab samples and wound biopsies with the biomarkers ph, hne and mpo.

Eligibility criteria:
inclusion criteria: * subjects with an exuding chronic wound, presenting at study sites or associated clinical or home setting * aged 18 years and over * subjects who are able and willing to provide informed consent. exclusion criteria: * subjects with a wound in which it is not possible to take a wound swab: * wounds ≤ 2 cm2 in diameter. * subjects who are taking or have taken systemic antibiotics in the previous 7 days * wounds with scant or no exudate * wounds that do not have sufficient exudate to complete swab collection * wounds where the wound bed consists predominantly of exposed bone. * subjects currently confirmed positive for methicillin-resistant staphylococcus aureus (mrsa), extended spectrum beta-lactamase (esbl) producing bacteria, human immunodeficiency virus (hiv), hepatitis or severe acute respiratory syndrome coronavirus 2 (sars-cov-2) * subjects on immunosuppressive or cytotoxic drugs * anticoagulated patients who cannot undergo wound biopsy

Keywords: diabetic foot pressure ulcer varicose ulcer
rct: mako medial unicondylar knee arthroplasty vs oxford unicondylar knee arthroplasty

Conditions: Unicompartmental Knee Replacement; Osteo Arthritis Knee; Surgery

Summary: the overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in mako robotic uka versus jig-based oxford uka with navigation control. patients receiving the mako robotic uka (stryker ltd) will form the investigation group and those undergoing the jig-based oxford uka (zimmer-biomet ltd) with navigation control will form the control group. the primary objective in this study is to compare accuracy of component positioning as assessed by postoperative low radiation dose ct scan between conventional jig-based oxford uka with navigation control and mako robotic uka.


Eligibility criteria:
inclusion criteria: * • patient has medial unicompartmental knee osteoarthritis requiring primary uka * patient and surgeon are in agreement that uka is the most appropriate treatment * patient is fit for surgical intervention following review by surgeon and anaesthetist * patient is between 40-80 years of age at time of surgery * gender: male and female * patient must be capable of giving informed consent and agree to comply with the postoperative review program * patient must be a permanent resident in an area accessible to the study site * patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken exclusion criteria: * • patient is not suitable for primary uka e.g. multi-compartmental knee osteoarthritis, anterior cruciate ligament rupture * patient is not medically fit for surgical intervention * patient requires revision surgery following previously failed correctional osteotomy or ipsilateral uka * patient is immobile or has another neurological condition affecting musculoskeletal function * patient is less than 40 years of age or greater than 80 years of age * patient is already enrolled on another concurrent clinical trial * patient is unable or unwilling to sign the informed consent form specific to this study * patient is unable to attend the follow-up programme * patient is non-resident in local area or expected to leave the catchment area postoperatively

Keywords: alignment computer navigation implant position mako robot makoplasty unicondylar knee replacement
efficacy and safety study to evaluate mt-6548 in hemodialysis subjects currently receiving esas with anemia associated with chronic kidney disease in japan

Conditions: Anemia; Hemodialysis Dependent Chronic Kidney Disease

Summary: for hemodialysis subjects currently receiving esas with anemia associated with chronic kidney disease, demonstrate non-inferiority of mt-6548 compared to darbepoetin alfa using hb value and evaluate long-term safety of mt-6548.


Eligibility criteria:
inclusion criteria: * diagnosis of ckd * receiving hemodialysis or hemodiafiltration 3 times a week for more than 12 weeks prior to the screening period, excluding receiving home dialysis or combination of peritoneal dialysis. * being treated with esas for the recent 8 weeks prior to the screening period * mean of the two screening hb levels closest in time to the baseline visit is ≥9.5 g/dl and ≤12.0 g/dl * fluctuation between the two hb levels closest in time to the baseline visit during the screening period less than 1.5 g/dl * serum ferritin ≥ 100 ng/ml, or tsat ≥20% during the screening period * folate and vitamin b12 ≥ lower limit of normal during the screening period exclusion criteria: * anemia due to a main cause other than ckd: sickle cell disease, myelodysplastic syndrome, bone marrow fibrosis, hematologic malignancy, hemolytic anemia, thalassemia, or pure red cell aplasia * active bleeding or recent blood loss within 8 weeks prior to the screening period * rbc transfusion within 8 weeks prior to the screening period * received testosterone enanthate or mepitiostane within 8 weeks prior to the screening period * ast, alt, or total bilirubin \>2.5 x upper limit of normal during the screening period * uncontrolled hypertension (diastolic blood pressure \>110 mm hg or systolic blood pressure \>180 mm hg) at the first day of the screening period and day 1 * ophthalmic examinations during the screening period correspond to either of the following criteria; * no available fundal findings * findings indicating the presence of active fundal disease * severe heart failure (new york heart association class iv) * cerebrovascular disorder or acute coronary syndrome (hospitalization due to unstable angina or myocardial infarction), requiring hospitalization due to urgent percutaneous intervention for coronary or heart failure within 12 weeks prior to the screening period * current or history of malignancy. history of malignancy with no recurrence for the recent 5 years is not an exclusion criterion * new onset or recurrent event of deep vein thrombosis or pulmonary embolism within 12 weeks prior to the screening period * current or history of hemosiderosis or hemochromatosis * history of prior organ transplantation or scheduled organ transplant, or prior transplantation of hematopoietic stem cell or bone marrow * males and females of childbearing potential who are unwilling to use an acceptable method of contraception during the designated period (males: during the study and 90 days after the last dose, females: during study and 30 days after the last dose) * females who are pregnant or breast feeding, or are predicted to be pregnant
the clinical cure project of chronic hepatitis b in china

Conditions: Hepatitis B, Chronic

Summary: chronic hepatitis b is a global public health problem, with nearly 700,000 deaths each year because of hepatitis b-related diseases. recent studies have found that some patients who have used nucleot(s)ide analogues(nas) for some period can achieve higher hepatitis b surface antigen(hbsag) clearance rate(which is called clinical cure or functional cure) by using pegylated interferon. patients who achieve clinical cure will further reduce liver inflammation, fibrosis and risks of liver cirrhosis and cancer in the future. this study was initiated in may 2018 and plans to recruit 30,000 eligible patients. the enrollment conditions are as follows: 1. according with the diagnosis of chronic hepatitis b in the guideline of china in 2015; 2.18-60 years old; 3. more than 1 year history of nas therapy with hbsag ≤1500 iu/ml, negative hepatitis e antigen and hepatitis b virus dna\<100 iu/ml; 4. no contraindications of interferon. for the above patients, pegylated interferon was used for 1-2 years(combined with nas for at least 3 months).the primary goal of this study is to find out the optimal treatment for clinical cure.


Eligibility criteria:
inclusion criteria: * according with the diagnosis of chronic hepatitis b in the guideline of china in 2015 * 18-60 years old * more than 1 year history of nucleot(s)ide analogues therapy with hbsag ≤1500 iu/ml, negative hbeag and hbv dna\<100 iu/ml * no contraindications of interferon exclusion criteria: * allergy to interferon * alanine transaminase \>10 times of upper limit of normal(uln) or total bilirubin \>2 times of uln * existing or previous decompensated liver cirrhosis * white blood cells or platelet below the lower limit of normal * existing severe organ injury * combined with autoimmune diseases, psychiatric diseases, diabetes or thyroidism * confirmed or suspected malignant tumors * before or after transplantation * using immunosuppressor * pregnant or having a planned parenthood in 2 years * alcohol or drug addicted * infected by hiv * any conditions that is unsuitable to interferon therapy according to the doctors' judgement
pancreatic stent for distal pancreatectomy

Conditions: Distal Pancreatectomy

Summary: the purpose of this study is to compare outcomes of patients undergoing distal pancreatectomy with or without pancreatic stent


Eligibility criteria:
inclusion criteria: 1. patients undergoing distal pancreatectomy 2. signed the informed consents exclusion criteria: 1. recurrence patients 2. pre-operative anti-cancer treatment 3. patients with contraindication(hepatic/ respiratory/ renal dysfunction, etc ) 4. ajcc stage iv 5. pre operative oddi'ssphincter incision 6. operation non radical 7. pancreatic stent not at place

Keywords: distal pancreatectomy pancreatic stent post-operative pancreatic fistula
uric acid levels and migraine in children

Conditions: Migraine in Children

Summary: migraine is recognized as one of the most prevalent neurological disorders. the exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. the present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients

migraine is recognized as one of the most prevalent neurological disorders. the exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. the present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients patients diagnosed with migraine were included as the study group, while the control group consisted of patients who presented to the pediatric neurology clinic during the same period for neuromotor development follow-up examinations. migraine patients are influenced by multiple factors, including dietary habits, levels of physical activity, and various psychosocial determinants.

Eligibility criteria:
inclusion criteria: * patients diagnosed with migraine exclusion criteria: cerebral palsy non-migraine headache epilepsy multiple congenital anomalies congenital metabolic diseases control group inclusion criteria: healthy children exclusion criteria neuromotor developmental delay multiple congenital anomalies non-migraine headache epilepsy

Keywords: migraine children uric acid levels
qualitative study of preventive organization of the pelvic bedsores injured spinal cord

Conditions: Spinal Cord Injuries; Pressure Ulcers

Summary: the purpose of the protocol is the prevention of pelvic pressure ulcers within a care network of sci patients whose general organization refers to the medical literature and the recommendations of the ministerial circular of 18 june 2004. a conceptual framework for work (cfw) will be set up and semi-structured interviews will be conducted with patients and professionals. they will confirm or dismiss the cfw gradually with a refined coding as of domains and sub-domains of the skin preventing spinal cord injury related to the perceptions and behaviors of those involved in the sector. quality control will be provided by experts in qualitative research and interviews will be stopped when the analyzes will further refine the domains and subdomains. a final framework will be validated to modulate our organization.


Eligibility criteria:
inclusion criteria: * - paying patients: * spinal cord injured person from any level of injury and any post-traumatic period * age 18 to 65 years inclusive * person affiliated to the social security or receiving such a plan * main ambulation mode: wheelchair * agreeing to participate in interviews -- professional side: * medical and paramedical health professionals involved in the care sector or studied various professionals (administrators, insurers, ...) involved in the studied care sector * agreeing to participate in interviews exclusion criteria: * minors or patients older than 65 years * person unable to consent * who do not speak the french language * person refusing to attend meetings * hospitalized person without consent * cognitive pathologies incompatible with interviews * main wandering mode of patients: walking * protected adults

Keywords: prevention organization pressure ulcers
impact of a web-based mind-body awareness program on women undergoing infertility treatment

Conditions: Infertility, Female

Summary: the goal of this two-group parallel randomized controlled study is to determine the effect of a web-based mind-body-based awareness program based on meleis transition theory on fertility awareness and readiness levels in women receiving infertility treatment.

developing fertility awareness in women receiving infertility treatment can enable changes in lifestyle habits that can increase fertility. having and increasing fertility awareness in infertile individuals can increase the likelihood of pregnancy and having a healthy pregnancy, positively affect general health and reproductive health, and change negative lifestyle habits that can affect the treatment process for infertility. fertility readiness can be provided with fertility awareness and can positively affect treatment outcomes. this research will be conducted as a two-group parallel randomized controlled trial to determine the effect of a web-based mind-body awareness program based on meleis transition theory on fertility awareness and readiness levels in women receiving infertility treatment. the research will be conducted with women receiving infertility treatment at the in vitro fertilization unit of hacettepe university faculty of medicine. the sample will include women who volunteer to participate in the study, have started the infertility treatment process, have had at most two ivf attempts, speak and understand turkish, are at least primary school graduates, are not in any psychological or social support group, have not completed or are not currently participating in any mind/body program for fertility. a total of 78 women will be included in the study sample: 39 for the intervention group and 39 for the control group. the introductory information form, fertility awareness scale, fertility readiness scale, and satisfaction evaluation form will be used to collect the data. within the scope of the study, a web-based mind-body awareness program based on meleis transition theory will be applied to the women in the intervention group. the routine nursing care in the unit will be applied to the control group. research data will be analyzed using mean, standard deviation, median, quarts, percentage, minimum and maximum values, chi-square, and mann whitney-u tests.

Eligibility criteria:
inclusion criteria: * volunteering to participate in research * being diagnosed with primary infertility * starting the infertility treatment process * having attempted ivf at most twice before * being able to speak and understand turkish * being at least a primary school graduate * not taking part in any psychological or social support group. * not having completed or currently participating in any mind/body program for fertility. exclusion criteria: * women applying for frozen embryo transfer without ovarian stimulation * being diagnosed with secondary infertility * having a diagnosis of a chronic disease * having communication problems (vision, hearing)

Keywords: nursing infertility nursing theory fertility awareness
magnesium and tka pain

Conditions: Pain

Summary: the hypothesis of this study is that in staged bilateral total knee arthroplasty (tka, magnesium sulfate administered during the perioperative period of the first tka may decrease pain after the second tka. it is known that pain is greater in the second tka than in the first. therefore, we compared pain of the second tka between the magnesium and control groups.


Eligibility criteria:
inclusion criteria: american society of anesthesiologist physical status 1 - 2. patients scheduled to undergo staged bilateral tka exclusion criteria: american society of anesthesiologist physical status \>3 -