Kornimate/medical-research-clean huggingface dataset:
effects of rehabilitation incorporating gait training on clinical measures associated with chronic ankle instability

Conditions: Chronic Ankle Instability

Summary: this is a randomized controlled trial (rct) regarding the conservative treatment of chronic ankle instability (cai) with an impairment based rehabilitation program. individuals with cai have deficits in neuromuscular control and altered gait patterns. ankle destabilization shoes are used clinically and may improve neuromuscular control by increasing lower extremity muscle activation, which may improve gait patterns. the investigators' purpose is to determine whether a 4-week rehabilitation program that includes ankle destabilization shoes (experimental) has beneficial effects on self-reported function and ankle gait kinematics compared to traditional rehabilitation without destabilization shoes (control) in cai patients. in addition, the investigators will compare ankle strength and balance between cai patients and healthy individuals with no history of ankle injury prior to the 4-week rehabilitation. the investigators hypothesize the experimental group will have greater improvement in self-reported function and frontal and sagittal plane kinematics during walking compared to the control group. in addition, the investigators hypothesize that patients with cai will have a decrease in ankle strength and balance when compared to healthy individuals. the design is a single-blinded randomized controlled trial. forty cai patients will complete baseline self-reported function questionnaires and walking gait trials and then be randomized into control and experimental groups. both groups will complete 4-weeks of supervised rehabilitation with or without destabilization shoes and then repeat the questionnaires and walking trials.


Eligibility criteria:
inclusion criteria: * cai with a history of recurrent ankle sprains, with the first sprain occurring longer than 12 months ago. participants will have lingering symptoms, and disability, but have not actively sought treatment for their cai * all participants will be physically active: participating in some form of physical activity for at least 20 min per day, three times per week. exclusion criteria: * neurological or vestibular disorders affecting balance * currently seeking medical care for cai * history of prior ankle surgery * history of ankle sprain within the past 6 weeks * history of ankle fracture * diabetes mellitus * current self-reported disability due to lower extremity pathology that may adversely affect neuromuscular function * lumbosacral radiculopathy * pregnant * soft tissue disorders including marfan's syndrome and ehlers-dandros syndrome
unrelated stem cell transplantation for adults with hematopoietic disorders

Conditions: CML; ALL; AML; Myelodysplasia; Lymphoma; Myeloproliferative Disorders

Summary: this study performs hla matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. the incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. this study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.

this protocol identifies a standard-of-care method for unrelated stem cell transplantation in adults. performing this service in a consistent and documented fashion allows investigators to obtain informed consent from recipients. data is tabulated locally for quality-control comparisons with nationally-reported standards. as a condition of maintaining transplant center status and to have acess to nmdp-registered donors, ucsf submits clinical and outcome data to the nmdp. as a result, ucsf is contributing to the resolution of remaining uncertainties regarding particular transplantation practices.

Eligibility criteria:
inclusion criteria: * age \>15 and \<55 * adequate renal function with serum creatinine \<2.0 mg/dl * pulmonary diffusing capacity\>50% of predicted * cardiac ejection fraction \>40% as measured by radionuclide wall motion study or echocardiography * total bilirubin must be \<2.5 mg/dl. * alkaline phosphatase and ast must be less than three times the upper limit of normal * negative serology for the human immunodeficiency virus * available hla-matched donor * signed informed consent exclusion criteria: * no fully or single-antigen-mismatched sibling donor is available to donate stem cells * no active liver disease.

Keywords: aml all cml lymphoma myelodysplasia unrelated stem cell transplantation hematopoietic disorders
role of vitamin d supplementation as an adjuvant therapy intreatment of helicobacter pylori in children

Conditions: Helicobacter Pylori Infection

Summary: to study the efficacy of vitamin d in conjunction with helicobacter pylori treatment in children in eradication of helicobacter pylori.

o study the efficacy of vitamin d in conjunction with helicobacter pylori treatment in children in eradication of helicobacter pylori. our study include 2 patient groups: 1. st group included 100 child diagnosed helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive h.pylori eradication treatment and vitamin d as an adjuvant therapy . 2. nd group will also diagnosed helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive h.pylori eradication treatment only. helicobacter pylori treatment : 1. amoxcillin on 50 mg/kg/day for 2 weeks 2. clarithromycin 20mg/kg/day for 2 weeks 3. proton pump inhibitor 1mg/kg/day for 1month vitamin d dose..1000unit /day for 1 month

Eligibility criteria:
inclusion criteria: - age:4-18 years children with symptomatic h pylori infection presenting with (epigastric pain, persistent vomiting and hematemesis)diagnosed by upper gastrodeudonoscopy , rapid urease test and histopathologic examination of gastric biopsies from antrum and body of the stomach. exclusion criteria: * patient on vitamine d supplémentation * patient who has defect in vitamin d metabolism (chronic renal and hepatic patients, malabsorption syndromes) * patients who had received treatment of h.pylori previously .
closed-loop target controlled infusion in laparoscopic cholecystectomy

Conditions: Cholecystolithiasis

Summary: laparoscopic cholecystectomy applied to artificial pneumoperitoneum and the extent of surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to traditional hemodynamics index such as heart rate and blood pressure.in case of this, the investigators design this research to study the closed-loop target controlled infusion to anaesthesia of individualization guided by a narcotrend index monitor in laparoscopic cholecystectomy.

anesthetics alter electrocortical activity in a dose-dependent manner,and it is suggested that electroencephalographic(eeg)activity can provide a reliable basis for a surrogate measurement of hypnosis.an eeg monitor,the narcotrend index(ni),has proven useful to titrate hypnotic drugs.because it is a single composite measure monitored continuously,it has been used in controlled studies to automatically guide propofol administration.conversely,automated delivery systems for opioids have seldom been described using eeg activity there are no specific measures to quantify analgesia directly.nevertheless,in the interaction between opioid-hypnotic synergy and loss of consciousness,when the dose of analgesic administered is sufficient to inhibit autonomic response to noxious stimuli,then the required hypnotic concentration is only that needed to achieve loss of consciousness.moreover,a noxious stimulus such as laryngoscopy or periosteal pressure to the tibia may cause electrocortical activation with an increase in narcotrend index,which indirectly reflects the analgesic state or the level of antinociception.finally,an excitatory eeg arousal reaction resulting from nociceptive stimulation can provide a rational basis for analgesia administration.it can then be hypothesized that narcotrend index could also be the controlled variable for opioid administration.

Eligibility criteria:
inclusion criteria: 1. require general anesthesia 2. expected to last\>30 minutes 3. 18\~90 years 4. asa ⅰ\~ⅳ level exclusion criteria: 1. psychiatric illness 2. supraspinal neurological disorders 3. cranial neurosurgical procedures 4. patients equipped with a pacemaker

Keywords: closed-loop tci ni laparoscopic cholecystectomy
improvement in baroreflex sensitivity in osas

Conditions: Obstructive Sleep Apnea Syndrome

Summary: individuals with obstructive sleep apnea syndrome (osas) are at high risk for cardiovascular morbidity and mortality. the effect of long-term nocturnal therapy with continuous positive airway pressure (cpap) on daytime baroreflex sensitivity (brs), a predictor of cardiac death, was investigated in osas patients.


Eligibility criteria:
inclusion criteria: * obstructive sleep apnea syndrome exclusion criteria: * diabetes mellitus, chronic obstructive lung disease, coronary or valvular heart disease, congestive heart failure, renal failure, or endocrine dysfunction. moreover, none of them were taking b-blockers, vasodilators, or inotropic agents at the time of enrollment in the study.

Keywords: obstructive sleep apnea, baroreceptors
immediate implant breast reconstruction

Conditions: Breast Cancer

Summary: the purpose of this study is to study the impact of the immediate implant breast reconstruction for patients with mastectomy and postoperative chest wall radiotherapy

non applicable

Eligibility criteria:
inclusion criteria: * histologically confirmed breast carcinoma * patients planned for mastectomy with immediate single stage breast reconstruction using an acellular dermal matrix (strattice™, lifecell corporation) * patients planned to receive postoperative chest wall irradiation * age ≥ 18 years old * who performance status 0-1 * affiliation to a social security system * informed consent signed prior any study specific procedures exclusion criteria: * inflammatory breast cancer * tumors with extensive involvement of the skin * use of tissue expander * indication of postoperative chemotherapy * patients planned for bilateral mastectomy * history of previously treated ipsilateral breast carcinoma * usual contraindications for adm * medical debility precluding surgical treatment * psychological, social, geographical disorders or any other condition that would preclude study compliance (treatment modalities and study follow-up). * pregnancy or breast feeding * inability to attend or comply with interventions or follow-up scheduling, disability or difficulty preventing a proper understanding of trial instructions * legal inability or restricted legal ability

Keywords: mastectomy, reconstruction
steroid injection in idiopathic granulomatous mastitis

Conditions: Idiopathic Granulomatous Mastitis

Summary: granulomatous mastitis (gm) is a non-infectious inflammatory breast condition typically affecting young women, often following breastfeeding. management of gm often begins with anti-inflammatory medications and antibiotics. steroids, particularly intralesional corticosteroids, are considered the first-line treatment for gm due to their rapid anti-inflammatory and immunosuppressive effects. steroids help control symptoms such as painful lumps, swelling, and redness. steroids' effectiveness in providing symptom relief minimizes the need for more invasive treatments such as surgery.

granulomatous mastitis (gm) is a rare, non-infectious inflammatory breast condition typically affecting young women within five years of childbirth, often following breastfeeding. its etiology remains unknown, but histologically, gm is characterized by granulomatous inflammation with the presence of giant cells. clinically, it presents as a palpable mass, sometimes accompanied by lymph node enlargement, mimicking multifocal breast cancer. the disease may also present with abscesses and fistulas, complicating diagnosis and treatment. imaging studies such as ultrasound and mammography often reveal irregular masses and hypoechoic nodules, suggesting malignancy. consequently, biopsy is frequently performed to confirm the diagnosis, revealing chronic lobulitis and granulomas. management of gm often begins with anti-inflammatory medications and antibiotics, though these are generally ineffective without proper diagnosis. steroids, particularly intralesional corticosteroids, are considered the first-line treatment for gm due to their rapid anti-inflammatory and immunosuppressive effects. steroids help control symptoms such as painful lumps, swelling, and redness. while steroid injections are effective, they can cause side effects like skin atrophy and hypopigmentation, though these are typically temporary and resolve over time. steroids' effectiveness in providing symptom relief minimizes the need for more invasive treatments such as surgery

Eligibility criteria:
inclusion criteria: * women diagnosed with igm confirmed clinically and histopathologically , willing to undergo intralesional steroid treatment. exclusion criteria: * patients with active infections. * patients on immunosuppressive therapy. * pregnant women.

Keywords: idiopathic gm intralesional steroid injection
impact of osteopathy on pain after breast cancer surgery

Conditions: Breast Cancer

Summary: breast cancer can be painful following surgery or can develop later and remain persistent. pain occurrence is frequent with 50% of women developing sequelae pain of varying intensity with an impact on the quality of life. one of the priorities of the 3rd french cancer plan is to preserve quality of life. osteopathy, complementary therapy, may help to reduce inconvenience caused by the disease, treatments and their side effects (asthenia, anxiety and pain). the main objective is to assess the impact of osteopathic treatment on pain in patients following breast cancer surgery. the impact will be considered beneficial if the pain score (digital scale) in the intervention group is lower, by at least two points, than the pain score in the control group at the end of the study. this is a monocentric, randomized, parallel group, single-blind and prospective clinical trial.


Eligibility criteria:
inclusion criteria: * adult woman * surgery for a malignant breast tumor with sentinel lymph node technique * patient affiliated to a social security system * willing and able to provide written informed consent exclusion criteria: * under-age women * pregnant woman * surgery for a malignant breast tumor with lymph node dissection * receiving adjuvant therapy during the study * receiving physiotherapy sessions (other than those made in immediate post-operative) * participating in the space "au fil de soi": relaxing body massage and energy resonance by cutaneous stimulation (resc) * person under guardianship or supervision * patient with impaired cognitive functions or lack of understanding of the french language * presenting a contraindication for osteopathy (major infectious and inflammatory conditions, trauma and other severe diseases)

Keywords: pain quality of life osteopathy oncology surgery breast
study to test rizatriptan in the early treatment of acute migraine (0462-081)

Conditions: Migraine

Summary: the purpose of this study is to test the effectiveness of rizatriptan benzoate in the early treatment of an acute migraine attack.


Eligibility criteria:
inclusion criteria: * greater than one year history of migraine * attacks typically mild when they begin and progress to moderate or severe * experience 1-4 migraine attacks per month exclusion criteria: * more than 15 headache days per month * heart disease * uncontrolled high blood pressure
analysis of anterior chamber inflammation by optical coherence tomography

Conditions: Uveitis

Summary: a prospective, observational, case series investigating the feasibility of utilizing oct scans of the anterior chamber of eyes with uveitis.


Eligibility criteria:
inclusion criteria: * all patients presenting to cole eye institute with uveitis. exclusion criteria: * inability to provide informed consent, including non-english speaking and cognitively/mentally impaired. * severe corneal opacities preventing imaging of anterior chamber
a study to assess the clinical validity of konectom™ in adults living with neuromuscular disorders

Conditions: Spinal Muscular Atrophy

Summary: the primary objective of the study is to explore the convergent validity of smartphone-based konectom doas against in-clinic standard assessments. the secondary objectives of this study are to evaluate the test-retest reliability of smartphone-based konectom digital outcome assessments (doas); to determine the relationship between konectom upper limb doas and conventional upper limb assessments in clinical environments; to determine the relationship between konectom lower limb doas and status of ambulation in clinical environments; to evaluate group differences in smartphone-based konectom doas \[self-administered at home and in-clinic\] between person with spinal muscular atrophy (pwsma) and healthy subjects (hs); to evaluate the variability of konectom doas self-administered in everyday environment in hs and pwsma; to compare konectom doas between in-clinic supervised administration versus self-assessments in everyday environment in hs, pwsma groups; to evaluate the relationship of konectom doas against patient-reported outcomes (pros) in pwsma and to evaluate the clinical safety of konectom in pwsma.


Eligibility criteria:
key inclusion criteria: for pwsma * genetic documentation of 5q sma (homozygous gene deletion, mutation, or compound heterozygote). for healthy participants * age group matched with sma participants key exclusion criteria: for pwsma * change of disease modifying treatment (dmt) in the last 1 month. * recent history of bacterial meningitis, viral encephalitis, or hydrocephalus. * addiction (alcohol or another drug abuse). * presence of an implanted shunt for the drainage of cerebrospinal fluid (csf) or of an implanted central nervous system (cns) catheter. * hospitalization for surgery (i.e., scoliosis surgery or other surgery), pulmonary event, or nutritional support in the previous 2 months or planned within the study duration. * known pregnancy. note: other protocol defined inclusion/ exclusion criteria may apply.

Keywords: neuromuscular diseases spinal muscular atrophy digital technology digital outcome assessments smartphone digital biomarkers
using multimedia technologies to disseminate an hiv prevention

Conditions: HIV Infection

Summary: this rct will randomly assign 40 of the cbos to receive the multimedia intervention and training package (multimedia)and the other 40 to receive the original, manualized connect intervention and training package (traditional). the technology transfer process involves all agencies receiving four days of training and two planned technical assistance conference calls, by study investigative staff, in the first four months following training. telephone assessments completed by up to 6 staff at each agency will measure primary outcomes, mediating, moderating and process measure variables at baseline, 6, 12 and 18 months post-technology transfer. the primary outcome of the study is adoptions of the connect intervention. the unit of analysis is the cbo.


Eligibility criteria:
inclusion criteria: to be eligible for the study, cbos must have reported that they * had 501c3 status; * provided at least a minimum level of direct contact hiv prevention services to clientele; and * that their target population for services included heterosexual men and women. exclusion criteria: -
transversus abdominis plane (tap) block in laparoscopic gastric-bypass surgery

Conditions: Gastric-bypass Surgery; Opioid Consumption; Obesity

Summary: laparoscopic gastric-bypass surgery (lgbs) is one of the surgical treatments for morbid obesity, which is performed under general anesthesia. tap block is an analgesic strategy covering the dermatomes from t6 to l1 and consists of injecting local anesthetic in the tap between the costal margin and the iliac crest, where the thoracolumbar nerves (t6-l1) are located. as far as the investigators know, this analgesic technique has never been studied in lgbs. the investigators objective is to determine whether an ultrasound (us)-guided tap block provides improved analgesia during the first 24 hours after laparoscopic gastric-bypass surgery, compared to conventional therapy only.


Eligibility criteria:
inclusion criteria: * asa physical status i-iii * 18-70 years of age, inclusive * scheduled for elective laparoscopic gastric-bypass surgery. exclusion criteria: * contraindications to regional blockade (e.g., allergy to local anesthetics, coagulopathy, malignancy or infection in the area) * pregnancy * history of alcohol or drug dependence/abuse * history of long term opioid intake or chronic pain disorder * history of significant psychiatric conditions that may affect patient assessment * inability to understand the informed consent and demands of the study

Keywords: laparoscopic gastric-bypass surgery tap block
relationship between upper extremity' viscoelastic properties and functionality in subacute stroke

Conditions: Stroke; Stiffness of Right Hand, Not Elsewhere Classified; Muscle Tone Abnormalities; Functional; Bleeding

Summary: in stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living. investigating the relationship between the functions of the upper extremity muscles and viscoelastic properties is important in understanding the rehabilitation of individuals with stroke.

upper extremity functions of individuals will be measured and correlated with viscoelastic properties of upper extremity muscles. the box and block test will be used for the function test. the viscoelastic properties of the muscles will be measured with the myotonpro device. deltoideus, triceps, biceps, brachioradialis and extansor digitorum longus were evaluated with myotonpro. the tonus, stiffness and elasticity of muscles were recorded. assessments will applied bilaterally and average recorded.

Eligibility criteria:
inclusion criteria: patients who had ischemic svo 3-9 months ago individuals who have had a stroke for the first time mas ≤ 2 of spasticity in paretic upper extremity exclusion criteria: tia survivors presence of cognitive deficits ( mini-mental state examination score ≥ 24) presence of another neurological, neuromuscular or orthopedic disease presence of diseases that cause pain, such as fibromyalgia or arthritis comorbidity with depression or psychiatric illness