Kornimate/medical-research-clean huggingface dataset:
platelet kinetics after platelet transfusion for the placement of a central venous catheter

Conditions: Thrombopenia; Central Venous Catheter Placement

Summary: platcat study's purpose is to evaluate platelet kinetics after platelet transfusion


Eligibility criteria:
inclusion criteria: * admission en haematology unit * need for a central venous catheter * thrombopenia \< 50 g/l exclusion criteria: * patient protected by law * pregnant or breastfeeding women * peripheral thrombopenia * patient admitted in intensive care unit

Keywords: intensive care haematology platelets prophylactic transfusion
healthy bodies project to prevent childhood obesity

Conditions: Obesity, Childhood

Summary: the goal of this study is to evaluate components of a preschool-based intervention designed to (1) increase children's nutrition knowledge, (2) increase physical activity in childcare settings, (3) increase emotional, behavioral and eating-related regulation, and (4) provide guidance to parents/caregivers about appropriate parenting and child-feeding strategies that promote healthy eating behaviors, dietary patterns and physical activity in preschool-aged children. the long-term goal is to help children develop healthy habits that reduce risk for obesity.

findings from intervention studies designed to prevent obesity among preschool children are mixed. one approach to stemming the development of obesity in childhood is to alter children's choices and environments in ways that promote food literacy, acceptance of healthy foods, physical activity and self-regulation. research on factors that influence the development of obesity in children has identified factors in children's environments that are potential targets for prevention programs. the goal of this study is to evaluate the efficacy of components designed for a preschool-based approach to preventing obesity in children. using an innovative approach to optimizing behavioral interventions, the multiphase optimization strategy (most), we will examine the effects of a 28-week, randomized set of experiments designed to (1) increase children's nutrition knowledge, (2) increase physical activity in childcare settings, (3) increase emotional, behavioral and eating-related regulation, and (4) provide guidance to parents/caregivers about appropriate parenting and child-feeding strategies that promote healthy eating behaviors, dietary patterns and physical activity in preschool-aged children. participants will include over 1300 predominantly low-income preschool children ages 3 to 5 years attending center-based childcare settings in pennsylvania (\~100 classrooms). the proposed study will provide information on the most efficacious components that produce measurable changes in children's nutrition knowledge and obesity-related behaviors. the results of this study will be used to inform the design of a randomized controlled trial to prevent obesity in children.

Eligibility criteria:
inclusion criteria: * children ages 3 to 5 years enrolled in full-day, center-based childcare programs * caregiver ≥ 18 years of age * caregiver responsible for providing meals for child at least half of the time * fluent in english (caregiver and child) exclusion criteria: * developmental delays or disorders that affect learning, mobility and eating

Keywords: nutrition knowledge food literacy physical activity executive function emotion regulation eating regulation parenting food parenting
a multicenter trial of localized radiation therapy to inhibit restenosis (gamma v)

Conditions: Coronary Artery Disease

Summary: the objectives of this study are: 1. to show a reduction in the late thrombosis (lt) rate following percutaneous revascularization using current interventional techniques with new stent placement and intravascular radiation therapy (irt) with a long-term antiplatelet regimen (12 months) compared to the stented patients on short-term antiplatelet regimen (2 months) from the irt arm of gamma i trial. 2. to show equivalence in the lt rate following percutaneous revascularization using current interventional techniques without new stent placement and irt with a long-term antiplatelet regimen (6 months) compared to non-stented patients on short term antiplatelet therapy (2 months or less) from a pooling of the irt arms of the gamma i, scripps, and wrist trials.


Eligibility criteria:
inclusion criteria: 1. the patient has a restenosis of \>60% (by subjective angiographic determination of the minimal luminal diameter compared to the distal reference diameter) within a native coronary artery which has previously undergone stent placement. 2. the patient has a history, signs of, or laboratory studies that suggest coronary ischemia attributable to the target stenosis. 3. the study target lesion must be located in a restenotic native coronary artery measuring \>2.75 and \ 4 weeks previously. 4. the vessel 1 cm distal to the target lesion is \>2.5 mm in diameter. 5 patients age must be \>18 years and \<85 years. exclusion criteria: 1. attempts to treat lesions in other vessels during the procedure were unsuccessful. 2. the patient sustained a recent (\<72 hours) myocardial infarction defined as a serum ck 2x the upper limit of normal and elevated mb. 3. serum creatinine \>2.0 mg/dl. 4. the left ventricular ejection fraction is \<40%.
distance education versus usual care qualification in asthma care

Conditions: Asthma

Summary: the purpose of this study is to evaluate the effectiveness of multifaceted educational interventions in the care of asthma, conducted remotely over the platform telessaúders in teams of the family health strategy and the consequent clinical improvement patients.

cluster-randomized trial with follow-up of 6 months. the aim of this study is to determine whether multifaceted interventions performed at a distance for the care of asthma symptoms reduce overhead, improve asthma control and qualify the care provided to patients.

Eligibility criteria:
inclusion criteria: * practice:participate in the telessaúde/rs. minimal staff consisting of a general practitioner, nurse, nurse and community health agents (cha), ability to give at least ten patients diagnosed with asthma, located in a municipality to make available for free inhaled medication (short-acting bronchodilators and corticosteroids ) for the treatment of asthma and willingness to participate in the study. * patients: 5 to 45 years with a diagnosis of asthma made by a physician and register at least one consultation for asthma or an asthma-related hospitalization during the year preceding the beginning of the study. exclusion criteria: * patients with other chronic diseases with pulmonary complications such as tuberculosis, cancer and cystic fibrosis or those with severe mental illness

Keywords: asthma continuing education primary health care
rod shape changing after scoliosis correction surgery

Conditions: Scoliosis Idiopathic; Scoliosis, Severe

Summary: the change of the fixation-rod after posterior srew-rod fixation segmentdesis is not widely known. the recent development of the 3d scanning technics and the opportunities of the eos 2d/3d system made us possible to have the exact rod shape immediately after implantation, and at each control examination. these progressions made us available to follow up the shape changing of the fixation-rod, hereby the changing of the correction.

the adolescent idiopathic scoliosis can affect the 0,5-2% of the european population. one of the widely accepted treatment of severe scoliosis (cobb angle is over 40-50°, or more than 10° progression observed a year) is posterior correction segmentdesis with screw and rod instrumentation. as a scoliosis treatment center, about 90-110 scoliosis correction surgeries are performed in our department, using conventional preoperative planning, coronal and sagittal translation technique from posterolateral approach. an eos 2d/3d system is available in our department making possible the scanning of the patient with upright biplanar ultra-low dose x-rays technique. the stereos software makes us possible to reconstruct the surface of the spine, pelvis and lower limb. the biplanar modality of the images makes possible to 3d reconstruct any simple shape using cad (computer-aided design) softwares. the recent updates in the 3d scanning technology also made us possible to perform intraoperative scannings without harming the sterility. the aim of the study to define the change of the fixation-rod's shape after scoliosis correction surgery. main hypothesis: there is significant change in the rod shape after implantation secondary hypothesis 1: during the implant of the rod, it will loose from the prebent correction depending of the severity and rigidity of the curve. secondary hypothesis 2: in the early stage of the rehabilitation, after the mobilization the shape of the rod (and the spinal parameters) can change secondary hypothesis 3: after the 3. month postoperatively the shape of rod does not change anymore

Eligibility criteria:
inclusion criteria: * routine patient care of university of pécs medical school department of orthopaedics * diagnosed idiopathic adolescent scoliosis * scoliosis induced surgical indication (cobb-degree\>45) exclusion criteria: * early onset or adult degenerative scoliosis * scoliosis with known origin * the angle of the curve does not reach the criteria of surgical indication (cobb-degree\<45) * former spine surgery

Keywords: scoliosis posterior segmentdesis 3d scanning eos 2d/3d
assessing online interventions for men's' mental health and wellbeing

Conditions: Mental Health Wellness 1

Summary: the purpose of this study is to test a comprehensive, male-oriented, online screening and referral (screening for mental health; smh) and male-oriented online information and referral intervention program (man therapy; mt) to improve mental health and wellbeing with a focus on prevention of suicide and help-seeking behaviors among middle-aged men. the online programs will be offered together to maximize the effect on reducing suicide behavior and increasing mental health help-seeking behaviors for men. if successful in decreasing suicide behavior and ideation and increasing suicide help-seeking behavior, this intervention could be scaled up to contribute to a reduction in suicide behaviors and deaths across the country.


Eligibility criteria:
inclusion criteria: 1. men living in michigan; 2. 25-64 years of age at time of enrollment; 3. scoring in the moderate- to high-risk range (or answering positively on question 9) on the harvard department of psychiatry/ndsd scale (hands), scoring in the moderate- to high-risk range for anger on the dsm-5 level 1 cross-cutting symptom measure, or identifying any risk for suicide ideation or behavior on the columbia-suicide severity rating sale (c-ssrs); and 4. fluent in reading english exclusion criteria: 1. females 2. scoring in the low risk range on the harvard department of psychiatry/ndsd scale (hands), scoring in the low risk range for anger on the dsm-5 level 1 cross-cutting symptom measure, or not identifying any risk for suicide ideation or behavior on the columbia-suicide severity rating sale (c-ssrs); and 3. not fluent in reading english

Keywords: suicide prevention men's mental health depression suicide ideation and behaviors
cell therapy in chagas cardiomyopathy

Conditions: Chagas Cardiomyopathy

Summary: the purpose of this study is to determine effect of cell therapy in patients with severe dilated cardiomyopathy

this protocol describes a double-blind placebo controlled randomized clinical trial to evaluate the efficacy of bone marrow derived stem cell implants in 300 bazillion patients with dilated cardiomyopathy and heart failure in class iii or iv of the new york heart association. the primary endpoint of this study is to evaluate the effect of the autologous bone marrow stem cell implant in the increase of the ejection fraction of the left ventricle in comparison with a control group, under optimized therapy for dilated cardiomyopathy. secondary endpoints will evaluate the alteration in nyha functional class, mortality rate, physical capacity (by ergoespirometry), life quality (minnesota questionnaire) and pulmonary congestion in dilated cardiomyopathy patients the received the autologous bone-marrow stem cell implant.

Eligibility criteria:
inclusion criteria: * diagnosis of dilated cardiomyopathy according to who criteria * syndromic heart failure in functional class iii or iv of the nyha * enrollment and continuous follow-up in cardiac out-patient clinic * adequate medical therapy after optimization therapy * echocardiogram with an ejection fraction equal to or less than 35% by simpson's rule exclusion criteria: * valvular diseases, except functional mitral or tricuspid reflow * coronariography showing a significant lesion (obstruction of at least 50% of the lumen in the troncus or the main arteries - lad, cx, rc) in one or more arteries * serologic diagnosis for chagas disease or at least two of the following criteria: epidemiology, right bundle branch block, anterior hemi-block, apical aneurism * sustained ventricular tachycardia * abusive use of alcohol or illicit drugs * pregnancy * use of cardio toxic drugs * any co-morbidity with impact in life expectancy in 2 years * renal function compromised (creatinine above 2 mg/dl) * definitive implant of pace-makers, resynchronizers and cdis * heart failure with symptoms initiating less than 1 year ago * active systemic arterial hypertension or history of hypertension

Keywords: chagas cardiomyopathy dilated cardiomyopathy stem cells therapeutics randomized controlled trials
early antiplatelet for minor stroke following thrombolysis (east)

Conditions: Ischemic Stroke

Summary: the current guideline recommends to give antithrombotic treatment 24 hours after intravenous thrombolysis in acute ischemic stroke. however, early neurological deterioration will occur in some patients due to no antithrombotic treatment, which is closely associated with poor outcome. the current trial aims to investigate the effectiveness and safety of early antithrombotic treatment after intravenous thrombolysis in minor stroke.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old; * acute ischemic stroke patients who received intravenous thrombolysis within 4.5 hours of onset; * nihss ≤ 5 within 6 hours after the end of intravenous thrombolysis, and no bleeding transformation was found in head ct examination; * premorbid mrs ≤ 1; * signed informed consent. exclusion criteria: * premorbid mrs≥2; * uncontrolled severe hypertension (systolic pressure \>180 mmhg or diastolic pressure \>110 mmhg after drug treatment); * antithrombotic treatment within 24 hours before randomization; * significant dysphagia and inability to take the experimental drug orally; * allergy or contraindication to study drugs; * comorbidity with any serious diseases and life expectancy is less than half a year; * participating in other clinical trials within three months; * patients not suitable for this clinical study considered by researcher

Keywords: thrombolysis minor stroke early antiplatelet
florida neonatal neurologic network

Conditions: Hypoxic-Ischemic Encephalopathy

Summary: create a database with selected medical information on infants born with hypoxic-ischemic encephalopathy (hie). in addition, the following samples will be collected in a bio-repository for future studies: blood, urine, and buccal samples.

the purpose of this study is to create a detailed medical and sample database of infants born with hie. both the medical information and the samples are de-identified. any future studies performed with the data and samples will receive institutional review board (irb) approval.

Eligibility criteria:
inclusion criteria: * gestational age greater than or equal to 35 weeks gestation * birth weight greater than or equal to 1.8 kg * less than or equal to 6 hours since insult occurred * severe hypoxic-ischemic encepholopathy (hie) exclusion criteria: * presence of lethal chromosomal abnormalities * severe iugr * significant intracranial hemorrhage with a large intracranial hemorrhage (grade iii or intraparenchymal echodensity (grade iv))
why in hospital - factors determining time to discharge readiness after arthroplasty surgery

Conditions: Pain; Nausea; Vomiting; Dizzyness; Fatigue; Organizational Concerns; Ect.

Summary: the purpose of this study is to evaluate patient related factors determining length of stay in hospital after arthroplasty surgery.

to evaluate why the patient is in hospital after surgery, when predefined discharge criteria are met, which patient related clinical problems hinder fulfilling of the discharge criteria, and to evaluate actual length of stay in hospital. all consecutive patients scheduled for total hip or knee arthroplasty are included in the trial.

Eligibility criteria:
inclusion criteria: * patients scheduled for total hip or knee arthroplasty exclusion criteria: * age under 18 years
non-invasive secondary respiratory support in late preterm and term infants

Conditions: Neonates; Respiratory Distress; Non- Invasive Ventilation

Summary: the aim of the present work is to compare between various modes of non-invasive respiratory support (including ncpap, nippv, and nhfov) as secondary respiratory support modes in late preterm and term neonates as regards the need for reintubation. additionally, the study aims at comparing between the three modes concerning the associated morbidity and mortality.


Eligibility criteria:
inclusion criteria: * the gestational age (ga) is between 34 and 41 weeks. * extubation from invasive mechanical ventilation initiated due to rd, irrespective to the cause of rd. * respiratory distress is assessed based on clinical manifestations (tachypnea, nasal flaring, intercostal retractions, diminished air entry, and or grunting) exclusion criteria: * major congenital anomalies. * major cardiac diseases. * presence of cardiovascular instability (sepsis, severe dehydration, severe anemia). * neurologically insulted neonates who are unable to take adequate spontaneous breathing.
the needs of cancer survivors

Conditions: Needs and Demands of Oncology Patients; Breast Cancer Patients.; Colon Cancer Patients.

Summary: a questionaire for cancer patients without an active treatment in order to evaluate their needs and/or demands.

cancer patients on finishing therapy will be interviewed by a registered nurse by a approved questionaire asking about his /her feeling needs and demands. efforts to help them will be trid it is well known from studies that survivors have unmet medical and non-medical needs that are not met, this includes physical, emotional and practical issues. the purpose of this study is to study them and investigate the methods how to alleviate them. all patients with breast and colon cancer that are refered to the rambam oncology center will be investigated.

Eligibility criteria:
inclusion criteria: * patients diagnosed with two common cancers (breast, colon) that have completed the treatment (chemotherapy, radiotherapy) * male and female patients 18-80 years old. exclusion criteria: * patients with active disease. * recipients of care that matches the criteria of hospice care. * patients with a diagnosis of dementia or other cognitive failure * patients who do not speak hebrew
integration of the cervical proprioceptive signals in patients with cervical dystonia

Conditions: Cervical Dystonia

Summary: the purpose of this study is to compare the cervical muscular force control , taking into account the proprioceptive signals, in patients with and without cervical dystonia.


Eligibility criteria:
inclusion criteria: * patients presenting focal or segmental cervical dystonia diagnosed by a neurologist expert in the diseases with abnormal movements * having signed a consent for study participation no inclusion criteria: neurological affection other than cervical dystonia (typical or atypical parkinsonism, other ...) * severe pain, trauma or disease of the cervical spine known or suspected other than cervical dystonia requiring treatment in the last 6 months * ongoing neuroleptic treatment * pregnancy or breastfeeding * lack of insurance coverage for patients, are added the following no inclusion criteria are added: * trembling cervical dystonia * injection of botulinum toxin in the past three months
a clinical study on the efficacy and safety of vec intravenous chemotherapy combined with conbercept intravitreal injection in the treatment of retinoblastoma

Conditions: Retinoblastoma

Summary: this prospective, multi-center, open single-arm phase ii clinical trial is designed to investigate the efficacy and safety of intravenous chemotherapy combined with conbercept intravitreal injection in the treatment of retinoblastoma.


Eligibility criteria:
inclusion criteria: 1. the patient's guardian signs an informed consent form and is willing to receive follow-up according to the schedule of the trial; 2. children of more than 3 months and under 5 years of age who have not received any anti-cancer treatment; 3. the target eye must meet the following requirements: clinically diagnosed as monocular retinoblastoma; according to the iirc diagnostic criteria, the treatment eye is classified as group e stage without clinical high-risk factors (table 1); no refractive medium turbidity and/or pupillary abnormalities that affect the fundus examination; iop≤21mmhg. 4. sufficient organ function at baseline. exclusion criteria: subjects with any of the following eye conditions: 1. patients diagnosed as stage e retinoblastoma in one eye, but with high-risk factors: neovascular glaucoma; refractive interstitial opacity caused by anterior chamber, vitreous or subretinal hemorrhage; tumor invasion of optic nerve posterior to the cribriform plate and choroid (range of diameter\> 2 mm), sclera, and anterior chamber; 2. treatment-naïve pediatric patients; patients with any of the following systemic diseases: 1. with a history of allergies or have allergic reactions to fluorescein sodium, with a history of allergies to protein products for treatment or diagnosis, and have allergic reactions to two or more drugs and/or non-drug factors, or suffering from allergic diseases; 2. low birth weight children, and severely growth-stunted children; 3. children who need systemic treatment for other system diseases; 4. any condition that should be excluded from the study in the opinion of the investigator.

Keywords: retinoblastoma conbercept vec intravenous chemotherapy
cardiopulmonary resuscitation in operating room

Conditions: Intraoperative Cardiac Arrest

Summary: in the last ten years patient safety during routine surgical interventions has increased; however as there is an increase in the number of specialized surgical interventions and high risk patients like elderly and emergency patients, the incidence of perioperative cardiac arrest has not reduced but remains fixed. the incidence of perioperative cardiac arrest varies from 4.3-34.6 for each 10,000 procedures. however as in a lot of other countries exact data are lacking also for turkey. with this study the investigators want to start collecting data about intraoperative cardiac arrest in turkey, starting at their institution the aim is to evaluate the incidence and outcome in the study. secondary aim is to assess the causes of cardiac arrest in the operating room.

patient information will be collected on a form entitled "data collection form" including all medications and interventions during cardiopulmonary resuscitation and routine daily used anesthesia registration form.

Eligibility criteria:
inclusion criteria: * all patients who develop cardiac arrest in the operating room exclusion criteria: * absence of informed consent * patients arriving into the operating room with ongoing cpr

Keywords: cpr cardiac arrest operating room