Kornimate/medical-research-clean huggingface dataset:
smartphone applications to improve lifestyles in olders over 65 years

Conditions: Telemedicine

Summary: this is a randomized controlled clinical trial performed in urban primary care centers in salamanca (spain). its objective is to evaluate the effect of an intervention based on the use of new information and communication technologies in a population of people over 65 years of age in the improvement of lifestyles, body composition, quality of life, cognitive performance and daily life activities.

* objective: to evaluate the effect of an intervention based on the use of new information and communication technologies in a population of people over 65 years of age. * design and setting: a randomized clinical trial of two parallel groups. population: 140 participants over 65 years of age will be included, selected by consecutive sampling in primary care centers of salamanca (spain. * measurements and intervention: lifestyles (physical activity, sedentarism and mediterranean diet), body composition, health-related quality of life, cognitive performance and daily life activities will be evaluated at 3 months. the advice on healthy diet and physical activity recommendations will be common to both groups. the intervention group will be added a training for 3 months in use of a smartphone application, designed to promote a healthy diet, increased physical acivity and decreased sedentary.

Eligibility criteria:
inclusion criteria: * informed consent signed * age between 65 and 80 years exclusion criteria: * cardiovascular disease * moderate or severe chronic obstructive pulmonary disease. * musculoskeletal disease that limits ambulation. * severe mental illness * score in the mini-mental \<24 points. * oncological disease in treatment.

Keywords: mhealth lifestyles elderly body composition cognitive performance quality of life
5 fr ultrahypofractionated wbi and sib for breast cancer with unfavorable characteristics

Conditions: Breast Cancer

Summary: this is a prospective, randomized, single-center, non-inferiority interventional clinical trial comparing whole breast irradiation (wbi) to a total dose of 26 gy in 5 fractions with simultaneous integrated boost (sib) to the tumor bed to a total dose of 30 gy, and wbi to a total dose of 40.05 gy in 15 fractions with sib to the tumor bed to a total dose of 48 gy (standard treatment), for young or unfavorable breast cancer patients.

the project refers to a study on patients with t1-t3 nx-n3 breast cancer, aged under 40 years or with unfavorable histology (lobular carcinoma, multifocal tumor, or histological subtypes luminal b her2 positive, hormonal receptors negative her 2 positive, triple negative breast cancer-tnbc-) treated with breast-conserving surgery (bcs) and radiotherapy to the whole breast (+/- lymph node areas) to a total dose of 26 gy in 5 fractions, with simultaneous boost (sib) to the tumor bed to the total dose of 30 gy, that will be compared with the current departmental standard of moderately hypofractionated radiotherapy to the whole breast, to 40.05 gy in 15 fractions, with sib to the tumor bed to a total dose of 48 gy.

Eligibility criteria:
inclusion criteria: 1. histological diagnosis of breast cancer 2. patients younger than 40 years regardless of histological subtype, or patients between 40 and 70 years with lobular carcinoma, histological subtypes luminal b her2 positive, or with hormone receptors negative and her2 positive (erbb2), or triple negative (tnbc) 3. signed informed consent 4. clinical stage t1-t3, nx-n3 5. negative surgical margins (≥ 0.2 cm) 6. clinical m0 in the previous 3 months 7. ps (ecog) ≤2 8. no previous thoracic radiotherapy 9. fertile women using contraceptive methods started during oncological treatment exclusion criteria: 1. patients with favorable characteristics (luminal a, luminal b her2 negative, ≥ 40 years) undergoing partial irradiation 2. patients who have undergone mastectomy 3. multicentric tumors 4. positive or close surgical margins (\<0.2 cm) 5. brca1/2 positive (only if known) 6. serious systemic diseases 7. mental or other disorders that may prevent the patient from signing the informed consent 8. previous invasive tumor, except skin cancer (excluding melanoma) unless the patient has been disease-free for at least 3 years (for example carcinoma in situ of the oral cavity or bladder) 9. collagen or autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, scleroderma, sjogren's syndrome) 10. evidence of distant metastases (m1) 11. contraindication to treatment systemic 12. pregnant women 13. non-compliance with the dose limits established in the treatment plan

Keywords: breast cancer whole breast irradiation simultaneous integrated boost adjuvant radiotherapy utrahypofractionated radiotherapy moderately hypofractionated radiotherapy
usability study of spaced retrieval exercise using mobile devices for alzheimer's disease rehabilitation

Conditions: Alzheimer's Disease

Summary: the focus of this work is to explore the use of modern mobile technology to enable people with alzheimer's disease to improve their abilities to perform activities of daily living and hence to promote independence and participation in social activities. this work also aims at reducing the burden on caregivers by increasing the ad patients' sense of competence and ability to handle behavior problems.

the investigators developed adcope, an integrated application that includes several modules that target individuals with alzheimer's disease , using mobile devices. the investigators developed two different user interfaces: a text-based and a graphic-based. to evaluate the usability of the application, participants with early stages of ad were asked to run the two user interfaces of the spaced retrieval memory exercise using a tablet mobile device.

Eligibility criteria:
inclusion criteria: - have early stages of alzheimer's decease

Keywords: alzheimer's disease rehabilitation
reducing high-risk geriatric polypharmacy via ehr nudges: pilot phase

Conditions: Fall; Congestive Heart Failure; Chronic Kidney Failure; Adverse Drug Event

Summary: polypharmacy is common among older adults in the united states and is associated with harms such as adverse drug reactions and higher costs of care. this pilot-phase project is designed to test two electronic health record (ehr)-based behavioral economic nudges to help primary care clinicians reduce the rate of high-risk polypharmacy among their older adult patients.

polypharmacy increases the likelihood of being prescribed and harmed by high-risk medications. as noted in the 2014 national action plan for adverse drug event (ade) prevention, polypharmacy both increases the likelihood of being prescribed high-risk medications and increases the likelihood that these high-risk medications will lead to adverse drug events. this pilot-phase study is intended to test clinicians' perceptions of ehr-based nudges designed to reduce high-risk polypharmacy among patients aged 65 years or more, thereby enabling investigators to refine the nudges, and to generate outcomes data that will inform power calculations for a subsequent larger study (the main study) of the nudges' effectiveness. in this pilot-phase study, the investigators will deploy 2 ehr-based behavioral nudges (a commitment nudge and a justification nudge) among 18 or more primary care clinicians in 3 primary care practices (6 clinicians or more per practice) affiliated with northwestern university for approximately 4 months. the 3 practices participating in the pilot will be a convenience sample of northwestern-affiliated practices known to study investigators. the investigators will randomly assign each of the 3 participating pilot practices to 1 of 3 arms: (1) commitment nudge, (2) justification nudge, or (3) both commitment and justification nudges. randomization will be at the practice level, without replacement, thus assigning exactly 1 practice to each arm. all participating clinicians within a given practice will receive the same nudges. northwestern-affiliated practices that do not participate in the pilot will constitute a fourth arm of this pilot study. the investigators will ask leaders of participating practices for their qualitative observations on how clinicians and patients experience the nudges (e.g., how the nudges affect workflows). the investigators also will collect data on the outcome measures before and during the approximately 4-month pilot period and compare these data to contemporaneous outcomes measures generated by northwestern-affiliated practices that do not participate in the pilot.

Eligibility criteria:
inclusion criteria: * primary care clinicians practicing in one of the participating northwestern-affiliated practices exclusion criteria: * none

Keywords: polypharmacy primary health care economics, behavioral deprescriptions decision support systems, clinical electronic health records geriatrics
tele-rehabilitation intervention in community-based healthcare for patients with osteoporosis (dheal-com-op)

Conditions: Osteoporosis; Older People

Summary: the dheal-com-op study is characterized as a feasibility study. the general objective is to evaluate the improvement in the physical performance of patients with osteoporosis detected through the performance-oriented mobility assessment (poma) scale, following a rehabilitation intervention integrated with the bts telerehab technology.

the dheal com project aims to evaluate the improvement in physical performance of patients with osteoporosis following a rehabilitation intervention integrated with technology in telerehabilitation. specifically, the project aims to develop a telerehabilitation platform that enables people to perform physical activity at home. the first objective of the project is to evaluate the improvement of physical performance, in terms of gait and balance capability, of patients with osteoporosis detected through the tinetti performance oriented mobility assessment (poma) scale following an integrated rehabilitation intervention with bts telerehab technology. forty elderly people with osteoporosis aged at least 65 years who wish to participate in the study and who meet the inclusion and exclusion criteria. participants will be randomized into experimental group (gs) and control group (gc). patients in the experimental group will receive a personalized program of home tele-rehabilitation exercises divided into 3 workouts per week, for a duration of 12 weeks. the training sessions will be organized as follows: one session will be carried out in telerehabilitation with the support of the physiotherapist in small groups of maximum 5 patients; in the remaining two the patient will perform the exercises independently at home. before starting the rehabilitation program, the patient will receive training with the technology in the hospital, in the presence of the physiotherapist. patients in the control group will be offered activities to perform at home, with the same frequency, in line with the usual care activities already proposed by the rehabilitation unit. patients will be contacted periodically by the physiotherapist to evaluate the improvement of the main and secondary outcomes detailed in the following protocol.

Eligibility criteria:
inclusion criteria: * patients with a positive moc for osteoporosis without a history of major fractures (femur and vertebrae); * functional ambulation category (fac) score ≥ 3; * stability of drug treatment for at least 1 month; * maintaining an upright position independently \> 30"; * mini-mental state examination (mmse) ≥ 24; * geriatric depression scale (gds) \< 2; exclusion criteria: * myocardial infarction or stroke within 6 months; * painful arthritis, spinal stenosis, amputation, painful foot lesions, or neuropathy that limits balance and mobility; * uncontrolled hypertension * metastatic cancer or immunosuppressive therapy; * significant visual or hearing impairment
longitudinal study for eosinophilic granulomatosis with polyangiitis

Conditions: Eosinophilic Granulomatosis With Polyangiitis; Churg-Strauss Syndrome

Summary: eosinophilic granulomatosis with polyangiitis (egpa) is a rare immune system disorder that causes asthma, an excessive number of eosinophils (a type of white blood cell) in the blood, and the inflammation of blood vessels, or vasculitis. in order to properly treat egpa, it is critical that the level of disease activity can be determined over the course of the disease. the purpose of this study is to determine new biological markers, or biomarkers, that may be used to assess the severity of this disease in people with egpa.

egpa, also known as allergic granulomatosis angiitis, is a systemic vasculitis. egpa is marked by three distinct symptoms: asthma; eosinophilia, evidenced by an excessive number of eosinophils in the blood and tissues; and vasculitis involving the skin, lungs, nerves, kidneys, and other organs. nerve involvement may also occur in egpa, causing pain, tingling, numbness, and muscle wasting in the hands and feet. because egpa patients may not show any visible signs of active disease, current methods of monitoring disease progression usually represent a period of extended inflammation and disease activity. thus, patients may go untreated during a period of undetectable disease when damage might be preventable. this study will use novel scientific methods to identify new biomarkers that can be used to monitor disease activity in egpa patients. these biomarkers may be used to help direct clinical care for egpa patients and assist in future drug development. study visits will occur every 6 months, or annually. blood and urine collection will occur at every visit. a physical exam and medical and medication history will at every visit; also, participants will be asked to complete several questionnaires to assess disease activity, health status, and tobacco, alcohol, and drug use.

Eligibility criteria:
inclusion criteria: patients with a diagnosis of eosinophilic granulomatosis with polyangiitis are eligible for the study. parent or guardian willing to provide informed consent, if applicable exclusion criteria: - inability to give informed consent and to sign the consent form

Keywords: egpa css
comparison of postoperative wound between dermabond prineo(2-octyl cyanoacrylate adhesive and polyester mesh) and subcuticular suture in simultaneous total knee arthroplasty

Conditions: Osteoarthritis, Knee Cutaneous Suture, Dermabond, Subcuticular Suture

Summary: this study aims to compare the clinical results of postoperative wound between dermabond prineo™(2-octyl cyanoacrylate adhesive and polyester mesh) and subcuticular suture in simultaneous total knee arthroplasty there is previous studies over whether or not to use skin adhesive material is superior or inferior to subcuticular suture this study prospectively randomized patients receiving bilateral total knee arthroplasty(tka). patients preference and clinical results was investigated in both knee of same patients who received skin adhesive or subcuticular suture in each knee.


Eligibility criteria:
inclusion criteria: * patients for total knee arthroplasty * having medicare insurance exclusion criteria: * rheumatoid arthritis * other inflammatory arthritis * neuropsychiatric patients * allergy or intolerance to study material * patients with an american society of anesthesiologists(asa) score of iv (angina, congestive heart failure, dementia, cerebrovascular accident)
relative bioavailability study to assess two solid formulations compared to an oral solution of azd3293 in healthy male and non-fertile female subjects

Conditions: Healthy Volunteers; Pharmacologic Action

Summary: this is an open-label, randomized, 3-period crossover, single dose study. three (3) single doses of azd3293 (2 different tablet formulations, and an oral solution) will be administered with a washout period of at least 1 week between the doses to investigate the relative bioavailability of azd3293 after administration via 2 tablet formulations compared with oral solution and to evaluate basic systemic pharmacokinetic parameters of the tablet formulations compared to the oral solution of azd3293. the safety and tolerability of azd3293 in healthy subjects will also be assessed in the study. azd3293 is being developed for the treatment of alzheimer's disease


Eligibility criteria:
inclusion criteria: 1. provision of signed, written, and dated informed consent prior to any study-specific procedures 2. healthy subjects must be able to understand and be willing to comply with study procedures, restrictions, and requirements. 3. male and non-fertile female healthy subjects, aged 18 to 55 years 4. body weight ≥50 to ≤100 kg and body mass index (bmi) ≥19 to ≤30 kg/m2 5. clinically normal findings on physical examination in relation to age, as judged by the investigator exclusion criteria: 1. history of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study 2. history or presence of gastrointestinal, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs 3. history of previous or ongoing psychiatric disease/condition including psychosis, affective disorder, anxiety disorder, borderline state and personality disorder according to the criteria in the diagnostic and statistical manual of mental disorders, 4th edition (dsm iv), as assessed by the mini-international neuropsychiatric interview (mini)

Keywords: phase i healthy volunteers azd3293 bioavailability pharmacokinetics
does the addition of massage to manual therapy and exercise improve outcome in chronic neck pain?

Conditions: Neck Pain

Summary: to date, the benefits of massage in chronic neck pain patients has only been investigated as a singular treatment, rather than as part of a treatment package. the need for this research has been highlighted in the literature (ezzo et al, 2007; haraldsson et al, 2006) this research aimed to establish whether the addition of massage to a program of exercise and manual therapy offers any additional benefits over exercise and manual therapy alone in the treatment of patients with chronic neck pain.

39 patients with neck pain of greater than three months duration were randomised to either a massage or non-massage group in a primary care setting in the dublin region. one therapist administered all treatments. randomisation was carried out by the use of sequential sampling, utilising permuted blocks. patients were excluded from the study if they had severe co-existing disease, had neck pain due to fracture, tumour, infection or other non-mechanical causes, or if the patient had a diagnosis of osteoporosis anywhere in the body. both groups underwent up to eight weekly physiotherapy sessions. the non-massage group received exercise, manual therapy and advice over the 30 minute intervention period, in conjunction with an exercise program to perform at home. the massage group received all of the above as well as swedish massage. follow up was for the duration of treatment only. a number of t-tests and non-parametric tests were conducted to establish if the two groups were comparable at baseline. a mixed anova was then used to analyse between-group and within-group data simultaneously. no blinding was possible, although the questionnaires were self-administered which may have limited bias.

Eligibility criteria:
inclusion criteria: * neck pain for greater than three months * over 18 years of age * had not received treatment for their neck pain in the previous month * could speak conversational english * were not involved in any current compensation case and * had provided written, informed consent. exclusion criteria: * severe co-existing disease, * neck pain due to fracture, tumour, infection or other non-mechanical causes, * if the patient had a diagnosis of osteoporosis anywhere in the body.
trial on impact on the hospital stay, of an early oral nutrition protocol applied to patients after total gastrectomy. (dopgt_2015)

Conditions: Early Oral Nutrition After Total Gastrectomy; Gastric Cancer

Summary: this is a prospective randomized controlled clinical trial to clarify the effect of early oral nutrition introduction after total gastrectomy in gastric cancer patients on the length of hospital stay, comparing an experimental group vs control group.

the total gastrectomy is a high complexity surgery that involves a high morbid-mortality. in our center, the postoperative management consisted in 1 week period of non oral intake and total parenteral nutrition. at the 7 day, an oral contrast image is performed to prove the correct function of the anastomosis, in witch case, a progressive oral diet is begin. in the late 90s, the fast-track concept (or multimodal perioperative patient care) was introduced in the surgical patients attempting to improve their postoperative course. this new concept includes the preoperative advices related to the surgery, the intensive mobilization after surgery, the early oral diet, and to avoid the routinary use of the nasogastric tube. some groups have been trying to apply this fast-track program sporadically in patients submitted to an elective total gastrectomy for gastric cancer, even do, there is still no good evidence to sport these practice. based on the reasons exposed before, the investigators design a prospective randomized controlled trial in gastric cancer patients underwent on a total gastrectomy comparing two groups. 24 hours after gastrectomy the investigators will administer oral methylene blue and if no evidence of drainage leakage the participants will be randomized into two groups: one of them with our classical postoperative management, and the other one implements an early oral nutrition protocol, having in considerations its effectiveness, security, and impact on the hospital stay.

Eligibility criteria:
inclusion criteria: * all patients requiring radical total gastrectomy for gastric cancer. * 18 or above years old. * acceptance and signing the full informed consent. exclusion criteria: * patient with poorly controlled diabetes mellitus (glycosylated hemoglobin levels greater than 7%) * emergency surgery. * total gastrectomy with esophagus-jejunal manual suture. * early dehiscence of esophagus-jejunal anastomosis (first 24 hours). * reintervention for abdominal complication in the first 24 hours. * surgery involving large intestinal or colon resections. * proximal resection margin affected requiring a esophagectomy and reconstruction with coloplasty.
diagnosis of transient tachypnea of newborn

Conditions: Transient Tachypnea of the Newborn

Summary: transient tachypnea of the newborn (ttn) is the most common cause of respiratory distress in fullterm newborn. ttn is a diagnosis of exclusion, it is primarily diagnosed based on medical history and typical clinical presentation. lung ultrasonography is an accurate, non invasive and reliable tool for diagnosing ttn. cardiometry is presently the only tool to evaluate thoracic fluid content continuously and noninvasively at the bedside.


Eligibility criteria:
inclusion criteria: * fifty newborns with gestational age ≥ 34 weeks (calculated from the first day of last menstrual period and using new ballard score) diagnosed with ttn exclusion criteria: 1. gestational age less than 34 weeks. 2. major congenital abnormalities. 3. congenital heart diseases. 4. neonatal sepsis. 5. neonatal pneumonia. 6. other causes of respiratory distress (rd)