Kornimate/medical-research-clean huggingface dataset:
high intensity aerobic interval training versus continuous training in heart failure patients.

Conditions: Heart Failure

Summary: to determine the effect of high intensity aerobic interval training versus continuous aerobic training in heart failure patients.


Eligibility criteria:
inclusion criteria: * patient with heart failure including both male and female * patients who can perform 6 mwt. * according to classification of american heart association, class 1 heart failure patients are included. exclusion criteria: * heart failure patients along with orthopedic problems. * patients who have use pacemaker. * patient who have recent acute myocardial infraction or revascularization less than 3 months.
subacute effects of spinal mobilization to treat subacromial impingement

Conditions: Subacromial Impingement Syndrome

Summary: specific aims and hypotheses aims to investigate the incremental benefits of cervicothoracic spinal manipulation in addition to shoulder mobilization and exercise for improving range of motion, pain, physical function and fear avoidance beliefs in patients with subacromial shoulder impingement. hypotheses it is hypothesized that those subjects who receive spinal manipulation in addition to shoulder mobilization and exercise will achieve greater improvements in range of motion, pain, function and fear avoidance beliefs at two weeks following treatment conclusion, at 4 weeks following treatment conclusion, and at discharge when compared to the subjects who did not receive the spinal manipulation.


Eligibility criteria:
inclusion criteria: * to be eligible, participants must meet the clinical prediction rule for unilateral subacromial shoulder impingement including: a) positive hawkins-kennedy impingement sign, b) positive painful arc sign, and c) weakness in external rotation with the arm at the side exclusion criteria: * individuals with contraindications to treatment with mobilization and manipulation (appendix a) will be excluded
advanced magnetic resonance imaging in temporal lobe epilepsy

Conditions: Temporal Lobe Epilepsy

Summary: we aim to o evaluate the role of conventional and advanced mri sequences in diagnosis of idiopathic temporal lobe epilepsy including identification and lateralization of epileptogenic focus.

patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at neurology department of assuit university hospital will be included in the study mri study will be done for each patient. mr imaging will be performed on a 1.5-t mr imaging unit (siemens, sembra medical system,german). prospectively completed data forms will be analyzed and compared. statistical tests appropriate to the nature of the data will be used. all patients will not be subjected to risk of any kind during this study. all patients' data will be confidentially kept. approval of the ethical committee of faculty of medicine, assiut university. an informed consent will be taken from all patients included in this study. the research will be conducted only by scientifically qualified and trained personnel. the procedures included in this study have been already used in hospital and centers in and outside egypt

Eligibility criteria:
inclusion criteria: * patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at neurology department of assuit university hospital will be included in the study based on the following criteria: * clinical features consistent with seizures of temporal lobe origin. * focal ictal temporal lobe patterns recorded with eeg. * no lesion detected by conventional mr imaging other than mesial temporal sclerosis. exclusion criteria: * any general contraindication of mri in some cases as presence of para magnetic substance as pacemakers or in patients with claustrophobia. * subjects with age less than 12 year old. * patients with any structural lesion other than mesial temporal sclerosis identified on mr brain imaging.
retarded phosphatidylcholine versus mesalazin in remission of ulcerative colitis.

Conditions: Ulcerative Colitis

Summary: the purpose of this study is to evaluate if retarded phosphatidylcholine is as effective as mesalazin in preventing an acute episode in ulcerative colitis. the hypothesis is, that ulcerative colitis is cuased by a defect in the barrier function of the colonic mucus. the background of the study is the finding that the phosphatidylcholine content of the colonic mucus is reduced in patients with ulcerative colitis, in both healthy and inflamed parts of the colon.


Eligibility criteria:
inclusion criteria: * diagnosis of ulcerative colitis in remission (cai 3 or less) * signed letter of content * no steroids or immunosupressants in the last 6 weeks * at least 5 relapses in the last 3 years * last relapse was 8 months ago or less * complete colonoscopy at entry exclusion criteria: * pregnancy or breast feeding * steroids or immunosuppressants * acute episode of uc * condition after complete or partial colektomy * known intolerance to mesalazin * severe medical disease other than colitis

Keywords: remission mesalazin non-inferiority study relapse
feasability of foot reflexology to alleviate anxiety in palliative care unit (rpasp)

Conditions: End Stage Disease

Summary: the primary purpose of the study is to know if foot reflexology can be accepted by patients hospitalized in palliative unit care (assessed by the number of patient who accept to participate), and if it is feasible (assessed by the realization of one session in normal condition : duration of 15-20 min, in supine position/seated or half-seated position).the investigators make the hypothesis that patients will accept to receive foot reflexology, and maybe feel less anxious after one session.

the patients will receive an informative content about the study and will have 24 hours of reflexion. if they accept to participate to the study, they will be randomised in one of the two groups : foot reflexology or "toucher massage" (for those randomised in the "toucher massage" group, a session of foot reflexology will be proposed in a second time). the investigators will assess the level of anxiety, the quality of the sleep and the pain using the esas scale, before and after the session. 24 hours after the session, they will be interviewed about what they felt with the session. the investigators will also have a look on the anxiolytic and antagic medication they consume before and after the session.

Eligibility criteria:
inclusion criteria: * adult able to give consent, man or woman, hospitalized in palliative care unit, with vigilance criteria from +1 to -3 on the richmond scale. * affiliated to social security exclusion criteria: * painfull bone metastasis on the feet * foot amputation * foot bedsore * peripheral distal neuropathy, trouble of foot sensibility * agonic or pre agonic state * patients under juridical protection * refusal to participate to the study

Keywords: palliative care foot reflexology anxiety acceptability feasability
left bundle branch area pacing in heart failure patients with ejection fraction below normal

Conditions: Left Ventricular Ejection Fraction Less Then or Equal to 50percent

Summary: while cardiac resynchronization therapy remains the mainstay for advanced hf, it is not always feasible due to unfavorable anatomy of coronary sinus or pacing characteristics. in such cases, left bundle branch area pacing itself or left bundle optimized cardiac resynchronization therapy could be a rescue therapy for failed or unsuccessful biventricular cardiac resynchronization therapy. however, the efficacy and safety of left bundle branch area pacing (or left bundle optimized cardiac resynchronization therapy) as rescue therapy for biventricular cardiac resynchronization therapy is largely hypothetic and lack concrete evidence still. therefore, there is an unmet need for the registry purposed for left bundle branch area pacing among heart failure with mid-range (or mildly reduced) ejection fraction and heart failure with reduced ejection fraction patients to investigate its efficacy and safety. this study aims to investigate the efficacy and safety of left bundle branch area pacing in heart failure patients with ejection fraction below normal using selectra catheters.


Eligibility criteria:
inclusion criteria: * patients previously diagnosed with heart failure with mid-range(or mildly reduced) ejection fraction and heart failure with reduced ejection fraction, which was documented by an appropriate echocardiographic study (left ventricle ejection fraction \<50%), and * patients with indications of cardiac pacing or cardiac resynchronization therapy exclusion criteria: * patients aged less than 19 years. * pregnant. * patients with an expected life expectancy of less than 1 year. * patients with a mechanical valve for the tricuspid valve. * patients who need atrial pacing only. * patients who are not capable of receiving a transvenous pacemaker for any reason.
transfusion of red blood cells, tranexamic acid and fibrinogen concentrate for severe trauma hemorrhage

Conditions: Hemorrhagic Shock

Summary: study design: single-center, not-randomized, open-label, two-arms controlled pilot clinical trial. health condition: patients with severe trauma with a need for transfusion and categorized as priority 0 or 1 according to the catalan health service (catsalut) polytrauma code (ppt)

major hemorrhage in the setting of severe trauma patient is associated with significant morbidity and mortality. hemorrhage is compounded by trauma induced coagulopathy of which hypo/dysfibrinogenemia and hypoperfusion play a significant role. there is a good evidence to suggest that hypofibrinogenemia in trauma is associated with worse outcomes and it is postulated that early replacement of fibrinogen and red blood cells packages may reduce hemorrhage and improve outcomes even in the pre-hospital phase of care. in this pilot study, the investigators will try to prove the feasibility and efficacy of managing the severe traumatic patient with red blood cells transfusion, tranexamic acid (txa) and fibrinogen concentrate compared to standard treatment based on crystalloid fluid and txa in the pre-hospital phase of care. early administration at pre-hospital phase of care of rbc, fc and txa is feasible , secure and can help controlling trauma induced coagulopathy. better outcomes in terms of mortality, less transfusion requirements and less crystalloid administration is expected

Eligibility criteria:
inclusion criteria: * age ≥18 years and * patients with severe trauma categorized as priority 0 or 1 according to the catalan health service (catsalut). polytrauma code (ppt) and * evidence of bleeding or a high bleeding suspicion according to physician judgment or o predicted to need transfusion according to tics (yale global tics severity scale) score ≥10. exclusion criteria: * moribund patient with devastating injuries and expected to die within 1-hour or * known objection to blood components transfusion or * known acquired or congenital coagulopathies not related to the actual trauma or * known anticoagulant treatment (vitamin k antagonist, dabigatran, rivaroxaban, apixaban) or * known pregnancy or * severe isolated traumatic brain injury or * hemorrhage not related to the actual trauma.
nutritional support in patients undergoing surgical treatment of colorectal cancer

Conditions: Colorectal Cancer

Summary: according to available data, 30-60% of patients are undernourished at hospital admission. the significance of the perioperative nutrition has already been studied in the 1930s. the outcomes of published studies demonstrated that patients with basic nutrient deficiencies have a higher frequency of postoperative complications and have a significantly longer recovery period. the main aim of the this prospective clinical trial is to evaluate the loss of muscle mass and strength of the patient, the self-sufficiency and the possibility of returning to normal activities, in relation to pre-operatively served nutritional supplements in patients undergoing elective surgery for colorectal cancer.

malnutrition is a pathological condition of the body caused by a deficiency of essential nutrients. the main feature is protein deficiency, which is caused by disruption of protein and energy balance and needs in the body. according to available data, 30-60% of patients are undernourished at hospital admission. the significance of the perioperative nutrition has already been studied in the 1930s. the outcomes of published studies demonstrated that patients that patients with basic nutrient deficiencies have a higher frequency of postoperative complications and have a significantly longer recovery period. in 1992, a randomized clinical trial "peri-operative nutritional support" showed that 85% of hospitalized seniors have malnutrition. the study demonstrated the need for nutritional training to prevent complications and clearly showed a relationship between malnutrition and reconvalescence length and mortality rate. in 2004, another large randomized trial ("randomized clinical trial of the effects of preoperative and post operative oral nutritional supplements on clinical course and cost of care") confirmed the relationship between malnutrition and the incidence of all perioperative complications. several other studies, which have been realized within the last decade, confirmed the positive effect of good nutritional condition on postoperative morbidity and mortality. to the best of the investigator's knowledge, all clinical trials dealing with the issue of preoperative nutrition (published up to now) were primarily focused on the research of the relationship between malnutrition and the frequency of postoperative complications. the main aim of the this prospective clinical trial is to evaluate the loss of muscle mass and strength of the patient, the self-sufficiency and the possibility of returning to normal activities, in relation to pre-operatively served nutritional supplements in patients undergoing elective surgery for colorectal cancer.

Eligibility criteria:
inclusion criteria: * age ≥18 years * resection of colon or rectum due to colorectal cancer exclusion criteria: * generalization of the disease * intestinal co-morbidity * duplicate malignancy

Keywords: nutritional support colorectal cancer muscle strength muscle mass self-sufficiency
impact of liposomal bupivacaine administered following placement of a transobturator suburethral sling

Conditions: Pain

Summary: liposomal bupivacaine or placebo will be administered at the end of a transobturator midurethral sling to determine if there is a difference in a patient's perceived postoperative pain.

the investigators aim to evaluate the use of liposomal bupivacaine to reduce postoperative pain from placement of transobturator slings for the treatment of stress urinary incontinence.

Eligibility criteria:
inclusion criteria: * adults \> 18 years of age * planning for outpatient surgical treatment of sui with placement of a transobturator suburethral sling under general anesthesia exclusion criteria: * pregnant or nursing * allergy to bupivacaine * history of drug/alcohol abuse * severe cardiovascular, hepatic, renal disease, or neurological impairment° * long-acting opioid within 3 days or any opioid use within 24 hours before surgery * contraindication to: * acetaminophen * oxycodone * non-steroidal anti-inflammatory drugs (nsaid) * administration of an investigational drug within 30 days before study * chronic pain syndromes * daily nsaid/opioid use * patients having concomitant procedures or not undergoing general anesthesia * patients who require a concomitant anterior repair or urethrocele repair will not be excluded as this requires the same dissection in the anterior vaginal wall.
pulmonary embolism prognosis model

Conditions: Pulmonary Embolism

Summary: the purpose of this study is to analyze the clinical manifestations, imaging features, and prognosis-related factors of pulmonary embolism, and to explore the prognosis risk assessment model for chinese patients

patients with pulmonary embolism and aged 18 years or older were enrolled in this study.patient demographic characteristics((age, sex, department, diagnosis, ), basic vital signs, symptoms at their admissions (hemoptysis, dyspnea, chest pain, syncope), laboratory examinations (blood lab routines, blood gas, liver and kidney function, myocardial marker), and imaging examinations (vascular ultrasonography, computed tomographic angiography, echocardiography, chest ct, ctpa, pulmonary perfusion imaging, pulmonary angiography, pet/ct) were collected by reviewing the cases. the prognostic information was collected by telephone follow-up. the follow-up end point was june 2024.

Eligibility criteria:
inclusion criteria: aged 18 years or older. discharged with the diagnosis of pe from peking union medical college hospital. exclusion criteria: diagnosed pe by other health care facility or transferred from other health care facility . without important follow-up data.

Keywords: pulmonary embolism
remifentanil dosing regimes for anesthesia in bariatric surgery: characteristics of early recovery

Conditions: Morbid Obesity

Summary: early recovery characteristics are important for patients' safety and operating room turnover. our aim was to compare fundamental methods for dosing remifentanil during morbid obesity surgeries: a manual infusion and a target-controlled infusion (tci). throughout study, patient's recovery time was tracked and compared between the groups.

introduction: the population of overweighted patients is increasing dramatically, therefore physicians face them in their daily practice (1-2). there are many guidelines showing the dose counting methods of intravenous anesthetics, but none of them are perfectly good for morbidity obese patients (3). early recovery characteristics are important for patients' safety and operating room turnover (4). aim: our aim was to compare fundamental methods for dosing remifentanil during morbid obesity surgeries: a manual infusion and a target-controlled infusion (tci). throughout study, patient's recovery time was tracked and compared between the groups. methods: 31 patients were evaluated who underwent bariatric surgery in hospital of lithuanian university of health sciences. all of them had received sevoflurane/remifentanil anaesthesia. remifentanil infusion was randomly assigned to a manual (control group) or to a tci (case group) method. we had evaluated patients' hemodynamics (arterial blood pressure, heart rate, saturation), spontaneous breathing and airway reflexes recovery time, time of extubation, eye opening, recovery of orientation and start of the following oral command. also we had registered concentrations of remifentanil in the blood (according to automatic infusion pump) while using tci method.

Eligibility criteria:
inclusion criteria: * morbid patients to whom, according guidelines (bmi \> 45 or bmi \> 35 and chronic disease) bariatric surgery is indicated. * patient's approval. exclusion criteria: * patients, younger than 18 years old. * patients who are higher than iii asa class. * patients who have higher sensibility to medications that are used during anesthesia. * patients with phycological disorders. * patients who can not fully communicate because of language barriers. * patients with surgical complications. * patient's disapproval.

Keywords: morbid obesity remifentanil manual infusion target - controlled infusion
use of a self-guided mindfulness mobile application to improve pain outcomes in individuals with knee osteoarthritis

Conditions: Osteo Arthritis Knee; Pain

Summary: this study will investigate if mindfulness training via a smartphone mobile app is effective in improving oa-related knee pain.

the investigator's primary aim in this study is to determine if regular use of a mindfulness application improves pain outcomes in adults with knee osteoarthritis. the investigator's secondary aim is to determine if self-reported healthcare-related quality of life (hrqol) scores predict response to mindfulness treatment in oa. the investigators hypothesize that the use of an mhealth intervention for mindfulness training may be an effective adjunct treatment of chronic knee osteoarthritis pain; specifically, that regular use of a mindfulness application will result in a statistically significant reduction in pain outcomes and improvement in physical function as determined by the koos scoring system. the investigators also hypothesize that those with lower baseline self-reported hrqol scores are more likely to see a greater improvement in their pain and function with use of a mindfulness application than those with higher baseline scores.

Eligibility criteria:
\*\*patients must be able to get care at nellis, scott, or travis air force base (a military installation) in order to participate in this study\*\* inclusion criteria: * male and female active duty members and dod beneficiaries ages 18-74 years * meet criteria for symptomatic knee osteoarthritis according to the american college of rheumatology (pain on more than half of the days of the past month during at least one of the following activities: walking, ascending or descending stairs, standing upright, or lying in bed at night) * demonstrate radiographic evidence of oa, with kellgren and lawrence (kl) grade ≥1 as determined by lead site investigator at each study location * must have access to a smartphone with enough memory to download the app my water balance or the mindfulness app exclusion criteria: * intra-articular corticosteroid injection in the 3 months prior to participation in the study. * intra-articular hyaluronic acid/prp injection in the 6 months prior to participation in the study * medical condition contraindicating moderate aerobic exercise as determined by their physician * history of knee surgery in the past 6 months or previous knee arthroplasty * inflammatory joint disease. * current practice of mindfulness * non-english-speaking * currently pregnant or planning pregnancy over the study period * enrollment in other clinical research study during the study period * inability to comply with treatment protocol, including participation in the rx3 home exercise program.