Kornimate/medical-research-clean huggingface dataset:
management of acutely symptomatic hernia

Conditions: Hernia; Emergencies; Surgery--Complications

Summary: acutely symptomatic abdominal wall hernia can cause many symptoms and complications. they can be associated with levels of morbidity beyond that seen in emergency laparotomy. there is limited data to guide practice in this field. this observational cohort study will explore variation in practice around assessment, repair and outcomes of hernias treated in the emergency setting.

there are many different types of hernia, with the most common being in the groin or at the umbilicus. hernias affect a significant proportion of the population and can vary from producing no symptoms at all, to causing a blockage to the bowel that requires urgent surgery. hernias affect people of all ages and degrees of health, but become increasingly common with age. as our population ages and therefore becomes generally more unwell, the risks of surgery increase. recent evidence suggests that emergency hernia repair is associated with worse outcomes than planned procedures. at present there are limited guidelines for the management of acutely symptomatic hernias and therefore practice varies between hospitals. this cohort study will capture information on patients treated in the uk for acutely symptomatic hernia, and will provide information on variation in assessment, and technical aspects of repair. it will also capture health utility data out to 90 days post discharge from hospital.

Eligibility criteria:
inclusion criteria: * patients aged 18 years and over * patients admitted directly to the emergency surgery service (via a+e or gp) * patients referred to the emergency surgical team by another inpatient specialty * patients with a diagnosis of an acutely symptomatic hernia made by a specialist surgical trainee (st3+) or consultant surgeon * willing to take part in the study exclusion criteria: * patients under 18 years of age * pregnant women * patients with a symptomatic parastomal, hiatal or diaphragmatic hernia * patients with a traumatic hernia * unable to consent

Keywords: outcome hernia emergency
effect of high cheese consumption on metabolic syndrome risk factors

Conditions: Metabolic Syndrome

Summary: the overall aim of the present research project is to examine whether consumption of high daily amounts of cheese, both high-fat and low-fat, affects risk markers of disease in a study population of men and women with metabolic syndrome risk factors. it will be explored whether high-fat and/or low-fat cheese consumption can be regarded healthy to consume for at-risk populations (assessed by within-group comparisons from baseline values) and if low-fat or non-fat alternatives to high-fat cheese should continue to be recommended (assessed by between-group comparisons). in addition, it will be assessed if cheese consumption affects women and men differently as suggested by observational data. the present research project will examine the health effects of cheese as a food product per se and not as a sum of single nutrients, knowing that the single components of cheese cannot be adequately placebo-matched. a relatively high daily intake of high-fat cheese will be compared to a similar intake of low-fat cheese and with a carbohydrate control.


Eligibility criteria:
inclusion criteria: men or women age 18-70 waist circumference \> 80 cm for women / \> 94 cm for men plus at least one additional established risk factor for the metabolic syndrome using the following criteria: * elevated bp (systolic bp \> 130 mmhg and/or diastolic bp \> 85 mmhg); * elevated triglycerides (\>1.7 mmol/l); * reduced hdl-c (\<1.0 mmol/l for men and \< 1.3 mmol/l for women); * elevated fasting glucose (\> 5.6 mmol/l). bmi 18.5 - 35 kg/m2 exclusion criteria: chronic diseases (known diabetes; cardiovascular disease; other chronic diseases which could affect the results of the present study) milk allergy use of dietary supplements incl. multivitamins (2 months before and during the entire study period) \>10 hours of strenuous physical activity per week use of prescription medicine which could affect the results of the present study including systemic glucocorticoids or medicine which have interactions with the intervention products (safety) drug or alcohol abuse blood donation \<1 month before study commencement and during study period simultaneous participation in other clinical studies pregnant or lactating women, or women who are planning to become pregnant within the next 6 months. inability to comply with the procedures required by the protocol

Keywords: cheese dairy saturated fat blood lipid concentrations lipoprotein particle size metabolic syndrome insulin sensitivity blood glucose concentrations
breath analysis in in adults with cystic fibrosis (cf)

Conditions: Cystic Fibrosis

Summary: exploratory comparative evaluation of exhaled breath composition in cystic fibrosis patients with age and gender-matched healthy adults in order to identify a disease-specific exhaled breath pattern as well as to gain insight into pathophysiological and microbial contributions to exhaled breath composition.

although there is some evidence that breath composition reflects aspects of cf pathology, so far a disease-specific molecular breath profile has not been identified. real-time, whole breath analysis incorporating all of the thousands of potentially relevant volatile compounds is needed in order to identify reliable cf-specific breath patterns. these may be used in future clinical applications to greatly enhance cost-effectiveness and simplicity of diagnostic testing for cf.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cystic fibrosis (for cf-patients) * age ≥ 18 years exclusion criteria: * previous lung transplantation (for cf-patients) * pulmonary exacerbation within the preceding 6 weeks (for cf-patients) * moribund or severe disease prohibiting protocol adherence (for cf-patients) * respiratory illness requiring physician consultation within the preceding 6 weeks (for controls) * chronic respiratory illness (for controls) * physical or intellectual impairment precluding informed consent or protocol adherence * pregnancy

Keywords: breath tests
improvement of hard endpoint in chronic hepatitis b patients treated with antiviral therapy

Conditions: Chronic Hepatitis B

Summary: patients who have completed 3 years follow-up of the past beijing science and technology commission research will receive another 7-years anti-viral therapy. patients will be assessed at baseline and every six months for blood cell count, liver function test, hbvdna, afp, prothrombin time, liver ultrasonography, and fibroscan. ct or mri and endoscopy will be performed at baseline and 7 years. at the end of the study, the cumulative rate of clinical hepatic hard endpoint will be calculated.

patients who have completed 3 years follow-up of the past beijing science and technology commission research will receive another 7-years anti-viral therapy. patients will be assessed at baseline and every six months for blood cell count, liver function test, hbvdna, afp, prothrombin time, liver ultrasonography, and fibroscan. ct or mri and endoscopy will be performed at baseline and 7 years. at the end of the study, the cumulative rate of clinical hepatic hard endpoint will be calculated.

Eligibility criteria:
inclusion criteria: * patients who have participated in the research funded by beijing science and technology commission and have completed 156 weeks follow-up. * patients comply with the requirements of the trail voluntarily * written informed consent exclusion criteria: * pregnant woman or patient with severe disease * patients with poor adherence to the study * patients not suitable for the study evaluated by the investigator

Keywords: liver cirrhosis
fertility and pregnancy after surgery ibd audit

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis; Fertility Disorders; Pregnancy Complications; Delivery Problem

Summary: crohn's disease and ulcerative colitis are chronic disease that are usually diagnosed at young age. the diseases and the associated treatment can impact on patient's sexual function, fertility, pregnancy, and delivery. this study aims to assess the impact of inflammatory bowel diseases on these aspects in female patients.

this is a cross-sectional, international, multicentre study. female patients diagnosed with inflammatory bowel diseases (crohn's disease and ulcerative colitis) treated at several italian centres will be retrospectively assessed for inclusion. those who underwent surgery below the age of 35 years between 2000 and 2020 will be included. the study aims to obtain information on female fertility, pregnancy and delivery, and to identify factors associated with infertility and problems to conclude the pregnancy. for each nation, at least one centre will collect data on patients who were not treated with surgery. patients who meet inclusion criteria will be asked to prospectively fill a questionnaire on fertility and pregnancy. data on treatments and demographic will be retrospectively collected by the local investigators and uploaded on a secure online database.

Eligibility criteria:
inclusion criteria: * crohn's disease diagnosis * ulcerative disease diagnosis * operated on before 36 years of age exclusion criteria: * younger than 18 years old at follow-up * no definitive diagnosis * no surgical procedures performed a subgroup of patients who did not undergo surgery will be used, at least one for each country.

Keywords: crohn's disease ulcerative colitis surgery
remimazolam versus propofol for general anesthesia induction in patients on renin-angiotensin system blockers undergoing robot-assisted laparoscopic prostatectomy

Conditions: Prostate Tumor

Summary: the investigators conduct a random assignment into either the remimazolam group or the propofol group. depending on the group assignment, either remimazolam (0.2 mg/kg) or propofol (1.0 mg/kg) is administered. if necessary, additional doses of remimazolam (0.1 mg/kg) or propofol (0.5 mg/kg) are given. the standard anesthesia procedure of our institution is followed, and blood pressure data recorded during the surgery is analyzed (mean arterial pressure \<65mmhg is defined as hypotension).


Eligibility criteria:
inclusion criteria: patients who undergo robot-assisted laparoscopic prostatectomy and who have taken renin-angiotensin system blockers for more than 3 months. exclusion criteria: 1. emergency surgery 2. if the subject includes those who cannot read the consent form (e.g. illiterate, foreigners, etc.) 3. cognitive dysfunction 4. atrial fibrillation, moderate to severe valvular disease, ejection fraction of 35% or less 5. patients who did not take renin-angiotensin system blockers on the day of surgery
effect of shr8058 on signs and symptoms of dry eye disease associated with meibomian gland dysfunction

Conditions: Treatment of Dry Eye Disease With Meibomian Gland Dysfunction

Summary: the study is being conducted to evaluate the efficacy and safety of shr8058 eye drops for patients with dry eye disease.


Eligibility criteria:
inclusion criteria: 1. signed icf (informed consent form) 2. subject-reported history of drye eye disease (ded) in both eyes 3. ability and willingness to follow instructions, including participation in all study assessments and visits exclusion criteria: 1. clinically significant slit lamp findings or abnormal lid anatomy at screening, including eye trauma, pterygium, active blepharitis, and active lid margin inflammation; 2. stevens-johnson syndrome or other severe systemic autoimmune diseases; 3. underwent lipiflow procedure or intention pulsed light therapy within 6 months before baseline, or received meibomian gland massage treatment within 2 weeks before baseline; 4. received or removed permanent lacrimal plug within 3 months before baseline; 5. ded secondary to scarring, radiation, alkali burns, cicatricial pemphigoid, or destruction of conjunctival goblet cells; 6. ocular or periocular malignancy; 7. active ocular allergies, or allergy to the study drug or its components; 8. ongoing ocular or systemic infection; 9. use of contact lenses within 1 month before screening; 10. intraocular surgery or ocular laser surgery within 6 months before enrollment; 11. uncontrolled systemic disease or history of herpetic keratitis; 12. use of topical steroids, topical cyclosporine, lifitegrast, serum tears, or topical anti-glaucoma medication within 60 days before screening; 13. used any known oral drugs that could have caused eye dryness within 1 month before screening; 14. participated in or were participating in other clinical trials drugs or device within 60 days before baseline; 15. inappropriate to participate for other reasons judged by the investigators.
multimodality us based on angio planewave ultrasensitive imaging and shear wave elastography to evaluate the malignancy risk value of thyroid nodules

Conditions: Multimoda Lultasound; Thyroid Cancer; Microvascular Classification

Summary: the goal of this clinical trial is to explore the value of a multimodal ultrasound model based on angio planewave ultrasensitive imaging, shear wave elastography and grayscale ultrasound in the differential diagnosis of benign and malignant thyroid nodules. the main questions it aims to answer are: can an innovative ultra-microvascular classification system based on angio planewave ultrasensitive imaging distinguish between benign and malignant thyroid nodules? how about the performance of multimodal ultrasound model to guide the fine-needle aspiration management of thyroid lesions? participants will: undergo grayscale ultrasound, swe, and angio planewave ultrasensitive imaging multimodal thyroid ultrasound examination within one week before surgery undergo surgery and obtain the postoperative pathological diagnosis


Eligibility criteria:
inclusion criteria: 1. age more than 18 years; 2. voluntarily signed informed consent; 3. have 1 or more thyroid nodules detectable by ultrasound; 4. participant underwent surgical procedure to confirm the pathologic results exclusion criteria: 1. nodules are accompanied by large calcifications followed by acoustic shadows 2. history of previous neck surgery or cancer, thyroid medications, radiation or surgical treatment; 3. poor quality of retained images or non-standard operations (such as intermittent scanning and improper probe compression), and incomplete pathological results.
a study of a glaucoma therapy to treat open-angle glaucoma or ocular hypertension

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * 18 years or older * diagnosis of open-angle glaucoma or ocular hypertension * other protocol-defined inclusion criteria may apply exclusion criteria: * under 18 * pregnant * other protocol-defined exclusion criteria may apply

Keywords: open-angle glaucoma ocular hypertension
intraocular pressure during robotic assisted laparoscopic procedures utilizing steep trendelenburg positioning

Conditions: Ocular Hypertension

Summary: the purpose of this study is to measure pressures within the eye (during surgery to remove the prostate or abdominopelvic masses) as the body position required for these laparoscopic procedures has been associated with increases in pressure within the eye.

the national cancer institute estimates that 218,890 new cases of prostate cancer will have been diagnosed in 2007. the three most commonly chosen options for localized prostate cancer are radical prostatectomy (rp), external radiation therapy (xrt), and interstitial brachytherapy (bt). a variety of surgical approaches are available, including open, laparoscopic, and robotic prostatectomy. with the current trend towards "minimally invasive" techniques, laparoscopic prostatectomy (lp) and, in particular, robotic assisted lp are on the rise. since gaining fda approval in 2001, the robotic procedure has gained over 1/3 of the market share. preliminary data suggests this number may now have grown to over 50% of all prostatectomies for cancer performed in the united states. the minimally invasive procedures offer some advantages relative to the open alternative: smaller incisions, improved pain control, decreased blood loss, and faster recovery have been well documented. cancer specific and quality of life (sexual function, continence) outcomes will need more long term evaluation before definitive advantages with the minimally invasive techniques are stated. furthermore, there are potential risks with these minimally invasive methods that have not been fully elucidated. during a laparoscopic or robotic prostatectomy, patients are subjected to a marked trendelenberg position throughout the majority of the procedure. the effect of body positioning has been shown previously to affect intraocular pressure (iop). however, the effect of surgical positioning on iop during prostatectomies has not been well studied and is not definitively known. anecdotal reports of postoperative vision loss following robotic assisted laparoscopic prostatectomy have surfaced thus further research is required to study the effect that these procedures for prostate cancer may have on iop and vision.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients choosing to undergo surgical treatment for prostate cancer exclusion criteria: * prior treatment of prostate cancer by any means * history of glaucoma, macular degeneration, or diabetic retinopathy * history of eye trauma/injury * history of non-refractive eye surgery * allergy to topical anesthetic (this will be used during the eye exam)
comparison of caudal block combined with general anesthesia and penile block and intravenous fentanyl in pediatric surgeries

Conditions: Caudal Block; Pediatric Urologic Surgeries; Fentanyl; Pediatric Delirium; Analgesia

Summary: urogenital surgery is one of the most frequently performed surgical procedures in the pediatric patient population. there is no consensus on which analgesic method is most effective for pain control in these patients. in clinical practice, if there are no contraindications, caudal block or penile block combined with intravenous fentanyl can be preferred as an analgesic method. in this study, the results of these two analgesia methods will be compared with the research.randomly selected participants will be compared by looking at parameters such as postoperative questionnaire results, walking time and urination time.


Eligibility criteria:
inclusion criteria: * 4 months - 12 years old male patient * acceptance of participation in the study * patients planned for urogenital surgery * asa i-ii patients exclusion criteria: * \ 12 years male patient * female patient * not accepted to be included in the study * asa status iii-iv * history of bleeding disorder * spinal cord disease * obstructive sleep apnea * developmental delay * behavioral disorder * allergy to any drug in the protocol

Keywords: pediatric urologic surgeries pediatric delirium caudal block penile block flacc scale paed scale
effect of aerobic exercises with selected phytoestrogens on hot flushes in menopausal women

Conditions: Hot Flashes

Summary: 50 menopausal women with the diagnosis of hot flushes were randomized to 1 of 2 groups group (a): it consists of 25 women who practiced treadmill exercise program for 30 minutes at 60% to 70% of maximum heart rate. the treatment sessions will be repeated 3 times per week for 12 weeks. group (b): it consists of 25 women who received diet modification contains soy products (phytoestrogen) such as soy milk and soy beans every day for 12 weeks only.

50 menopausal women with the diagnosis of hot flushes were randomized to 1 of 2 groups group (a): it consists of 25 women who practiced treadmill exercise program for 30 minutes at 60% to 70% of maximum heart rate. the treatment sessions will be repeated 3 times per week for 12 weeks. group (b): it consists of 25 women who received diet modification contains soy products (phytoestrogen) such as soy milk and soy beans every day for 12 weeks only.

Eligibility criteria:
inclusion criteria: * menopausal women minimum 2 years after menopause patients were required to have at least moderate hot flashes at time of randomization, having a score ≥ 40 in hot flash-related daily interference scale (hfrdis) exclusion criteria: * women with bmi \> 30kg/m2 ingestion of any psychotropic and antidepressant medications, any selective estrogen receptor modulator medications (e.g., tamoxifen and raloxifen), any aaromatase inhibitor medications (e.g., anastrozole, letrozole, and exemestane), leuprolide acetate, clonidine, gabapentin, pregabalin, amino acid supplements, over the counter (otc) medications that reduced hot flashes during the last 4 weeks, ingestion of estrogen and progesterone based medications, history of suicidal thoughts, substance or alcohol dependence (with the exception of nicotine dependence) during the last 3 months and electroconvulsive therapy (ect) during the last 2 months.
a study to evaluate the efficacy and safety of three experimental drugs in adults with hepatitis c virus infection, who are either treatment-naive or treatment-experienced in brazil

Conditions: Chronic Hepatitis C Infection

Summary: the purpose of this study is to evaluate the proportion of subjects achieving sustained virologic response 12 weeks post-treatment (svr12) in adults with genotype 1 (gt1) chronic hcv infection, who received treatment with 3 direct-acting antiviral agents (3-daas; ombitasvir/paritaprevir/ritonavir and dasabuvir) with or without ribavirin.


Eligibility criteria:
inclusion criteria: * females must be post-menopausal for more than 2 years or surgically sterile or practicing acceptable forms of birth control * males must be surgically sterile or agree to practice acceptable forms of birth control * chronic hepatitis c virus (hcv) infection at screening * fibrosis stage f3 or greater, documented by acceptable tests * participants with cirrhosis: absence of hepatocellular carcinoma (hcc) as indicated by acceptable methods exclusion criteria: * women who are pregnant or breastfeeding * positive test result for hepatitis b surface antigen (hbsag) or anti-hiv antibody positive (hiv ab) * use of contraindicated medications within 2 weeks of dosing * clinically significant abnormalities or co-morbidities * history of solid organ transplant * abnormal laboratory tests * current or past clinical evidence of child-pugh b or c classification or clinical history of liver decompensation

Keywords: chronic hepatitis c hepatitis c treatment naive hepatitis c genotype 1 hepatitis c treatment experienced hepatitis c virus
influence of posture and gas insufflation on perioperative lung function

Conditions: Pneumoperitoneum

Summary: perioperative airway resistance and lung function are evaluated perioperatively in patients, who undergo surgical procedures in different postures and with or without gas insufflation into the peritoneal cavity.

lung function, upper and lower airway resistance measurements are performed in patients in prone horizontal or head tilted down (40°) position. half of the patients with head down position will have surgery in laparoscopic technique (including gas insufflation to achieve a pneumoperitoneum). measurements are performed on the day prior to surgery, on the morning of surgery, 30 - 45 minutes, 2 hours, and 24 hours after extubation.

Eligibility criteria:
inclusion criteria: * patients older than 18 years of age. * patients with normal lung function with respect to age, gender and weight. -patients scheduled for prostatectomies, robotic prostatectomies, and open hemicolectomies. exclusion criteria: * patients younger than 18 years. * patients with pathological lung function. * patients with with major cardiac disease.

Keywords: vital capacity, fev1, airway resistance perioperative changes in lung function