Kornimate/medical-research-clean huggingface dataset:
variations in the dio2 and mct10 genes and effect of triiodothyronine treatment

Conditions: Hypothyroidism

Summary: hypothesis: variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with l-thyroxine and liothyronine in patients with persistent hypothyroid symptoms despite conventional l-thyroxine mono-therapy. purpose: to re-test this hypothesis in patients with continued perceived effect of liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. the study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.


Eligibility criteria:
inclusion criteria: * patients admitted to the department of endocrinology with the diagnose hypothyroidism because of persistent hypothyroid symptoms despite treatment with l-thyroxine mono-therapy and normal and stable tsh (for at least 6 months). * started in combination therapy with l-thyroxine and liothyronine in an approximately 17/1 ratio * exclusion of an alternative explanation for persistent hypothyroid symptoms exclusion criteria: * initiation of l-thyroxine treatment in patients with s-tsh below upper normal limit (with assay in current use, that is tsh \< 4 mu/l) * ongoing pregnancy * age below 18 years or above 80 years. * patients who do not read and understand information material given * patients who are not competent to give informed consent
a clinical study of theta burst stimulation (ctbs) in the treatment of insomnia disorder targeting the dentate nucleus of the cerebellum

Conditions: Insomnia Disorder

Summary: insomnia disorder (id) is a significant public health problem worldwide, with nearly a third of the general population experiencing insomnia symptoms in their lifetime. therefore, finding a safe, effective, and easy-to-use non-pharmacological method for treating id is urgent. repetitive transcranial magnetic stimulation (rtms) has been used to varying degrees in many neurological and psychiatric diseases and has broad application prospects for treating id.θ-burst stimulation is characterized by cluster stimulation.continuous stimulation (ctbs) mainly has inhibitory effects on the cortex. the inhibition of motor-evoked potentials can last for 60 minutes, which is longer-lasting, has a lower stimulation intensity, and is shorter in duration than traditional rtms. there are no reports on clinical studies of ctbs treatment for id. so far, sleep research has mainly focused on the interconnections between the neocortex and subcortical structures, while cerebellar activity has been largely overlooked.the mechanism of rtms treatment for insomnia with the cerebellum as the target is unclear. this study proposes to apply ctbs mode to the cerebellar dentate nucleus for rtms treatment in patients with id to explore its effectiveness and safety in improving insomnia disorder.


Eligibility criteria:
inclusion criteria: * all participants aged from 18 to 60 years old; all participants met diagnostic criteria for insomnia disorder according to the diagnostic and statistical manual of mental disorders-v (dsm-v), and scored \>10 on psqi , ≤14 on the hamilton anxiety scale (hama), and ≤17 on the hamilton depression scale (hamd); no sleep-affecting drugs were taken 1 month before or during the trial (non-prescription sleep medication, benzodiazepines or hypnotics, ect.); patients can cooperate to complete the treatment and related examination items; all subjects signed informed-consent forms before enrolling in the trial. exclusion criteria: * the patient is unable to cooperate with the completion of treatment and examinations; there are other types of sleep disorders; a history of psychotropic drug or alcohol dependence or abuse in the last 2 years; have undertaken trans-meridian travel across more than two time zones or worked night shifts in the preceding one month or during the trial period; plan surgical treatment within 1 month before or during the trial; evidence of neurological or other physical diseases such as respiratory, cardiac, renal, hepatic, endocrinal diseases and other psychiatric diseases as assessed by clinical history, physical examination or routine laboratory tests; pregnancy or breastfeeding women; any contraindication for rtms (including implanted metal and devices in the body, and history of epilepsy); concurrent other clinical trials; patient or family member withdraws informed-consent.
to investigate the effects of robotic-assisted gait training in stroke patients

Conditions: Stroke; Cerebrovascular Disorders

Summary: the primary aim of the study was to investigate the effects of robot-assisted gait training and virtual reality on knee joint position sense in patients with chronic stroke. the secondary objective is to examine the effectiveness of these applications on functional gait and balance.

despite widespread prevention programs worldwide and advances in acute and subacute management and treatment protocols, stroke remains one of the most common causes of adult disability, representing a serious global health problem. sensory motor dysfunction, proprioception deficits and hypertonus may develop in stroke patients depending on the location and severity of the brain damaged areas. virtual reality application, which has been widely used in recent years, is a three-dimensional, computer-generated technology that gives the patient a sense of reality and allows the patient to interact with it. virtual reality application can be used as a suitable method for proprioceptive rehabilitation due to its ability to manipulate visual feedback of virtual objects. in recent years, another technological method that has been used in the field of neurorehabilitation is robotic rehabilitation. robot-assisted gait training, which requires repetitive tasks, can enhance neuroplasticity and motor learning, which focuses on the rearrangement of brain tissue. both technology-based rehabilitation approaches have been shown to be particularly effective in improving the sense of position in the upper extremity. however, studies investigating the effects of these two applications on lower extremity position sensation seem to be insufficient. we think that both methods will be effective in improving the sense of position.

Eligibility criteria:
inclusion criteria: * having been diagnosed with stroke by specialist physician, * 6 months after stroke diagnosis, * hemiplegia or hemiparesis due to stroke for the first time, * being over 18, * being able to walk with auxiliary device or independently, * mini mental test score\> 24, * functional ambulation classification fac ≥ 2, * agree to participate in the study. exclusion criteria: * acute internal discomfort, * botulinum toxin administration during 6 months before treatment or during treatment, * presence of a history of previous stroke, * having influence on both sides, * neglect syndrome, * presence of severe spasticity (modified ashwort scale\> 2), * patients weighing more than 100 kg, * patients with femoral lengths greater than 50cm

Keywords: joint position sense stroke virtual reality robot assisted gait training
motor imagery practice in neurological rehabilitation

Conditions: Stroke; Brain Injury; Multiple Sclerosis

Summary: motor imagery is a technique widely used in learning skills. its effectiveness has been proven in various sports and in musicians. a recent review (braun et al. 2006) suggested that this technique may also be effective in rehabilitation of patients with neurological disease or damage, but that further research was needed. the main purpose of this research is to discover whether motor imagery practice is beneficial in the rehabilitation of skills in patients who have some disability due to neurological disease or damage. the principal research question is: are physiotherapy and occupational therapy given incorporating motor imagery more effective than standard care (i.e., the same therapies but without integrated motor imagery) in re-training task specific performance for patients with neurological disease or damage?


Eligibility criteria:
inclusion criteria: * participating in a rehabilitation program for problems arising secondary to disease or damage affecting the central nervous system (usually stroke, brain injury, multiple sclerosis) * over 18 years of age * have sufficient language and memory skills to undertake the intervention (i.e. score positive on the first three items of the sheffield screening test) exclusion criteria: * any co-morbidity that would interfere with the ability to perform imagery as judged by the clinician or from the medical notes (e.g., schizophrenia)
evaluation of lungs of normal individuals by lung lavage, brushing and bronchial wall biopsy

Conditions: Smoking; Lung Diseases

Summary: the purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters. these will provide important information when applied to individuals with various pulmonary diseases, and will help in understanding of the etiology and pathogenesis of various lung diseases.

study procedures will be performed at the weill cornell medical college-new york presbyterian hospital and/or weill greenburg york avenue building. study procedures done elsewhere that are within the protocol timeframe will be accepted if seen fit by the investigators so that they are not repeated unnecessarily. study individuals who undergo bronchoscopy with intravenous administration of sedatives and analgesia may be required to stay overnight. bronchoscopy is normally an ambulatory procedure. the subject is observed after the bronchoscopy, including vital signs and level of consciousness, until they are back to baseline. an overnight stay would only be required if the individual was not, in the judgment of the attending physician, safe to be discharged as is standard practice. follow up of all participants are carried out by telephone within 1 wk following the procedure. rockefeller university has been added as a second site. individuals undergoing bronchoscopy without intravenous administration of sedatives and analgesia are not required to stay overnight due to the lack of administration of cns-altering drugs and the limited sampling involved (tracheal brushes only).

Eligibility criteria:
inclusion criteria: * all study subjects should be able to provide informed consent * males or females ages 18 years and older. * must provide hiv informed consent. * non-smokers, ex-smokers and smokers. exclusion criteria: * individuals not deemed in good overall health by the investigator will not be accepted into the study. * drug and/or alcohol abuse within the past six months. * individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study. * individuals with allergies to atropine or any local anesthetic will not be accepted into the study. * individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study * females who are pregnant or nursing will not be accepted into the study

Keywords: healthy individuals smokers ex-smokers non-smokers
risk of osteoporotic fracture in home care patients in turkey

Conditions: Osteoporosis; Osteoporosis Risk; Osteoporotic Fractures

Summary: this study will assess the incidence of osteoporosis and osteoporotic fracture risk of registered home health patients in the anatolian side of istanbul.

after selecting the patients who have been visited by the team in the last 6 months from the patients registered in the home health system, the number of patients required to reflect the population will be determined, and patient files will be selected by randomization. demographic information, comorbidities, medications, and blood tests will be recorded. frax risks of the patients will be calculated, and it will be examined whether they have any previous fracture history and whether they have received treatment for osteoporosis.

Eligibility criteria:
inclusion criteria: being registered for home health services having made a call to home health services in the last 6 months exclusion criteria: patients that have passed away
colchicine in st-elevation myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: * there is evidence that inflammatory processes may play detrimental role during the acute phase of myocardial infarction * the hypothesis of this study is that colchicine, by its anti-inflammatory action, may lead to reduction in infarct size, when administered during the acute phase of myocardial infarction


Eligibility criteria:
inclusion criteria: the study will enroll patients 18 years old or older who present to the hospital within twelve (12) hours of the onset of chest pain and who had st segment elevation \>1 mm in two contiguous limb leads or st segment elevation \>2 mm in two consecutive precordial leads or new onset of left bundle branch block (lbbb) in a twelve lead electrocardiogram and for whom the decision was made to be taken to the cath lab to perform angioplasty of the coronary vessels. excluded patients: * \> 80 years old * with active inflammatory diseases, infectious diseases or known malignancy * under treatment with corticosteroids, anti-inflammatory agents or disease modifying agents * with known hypersensitivity-allergy to colchicine * under chronic treatment with colchicine * with severe renal failure (egfr \< 30 ml/min/1.73 m2) * with hepatic failure (child - pugh class b or c) * presenting with cardiac arrest * presenting with ventricular fibrillation * presenting with cardiogenic shock * with stent thrombosis * with angina within 48 hours before infarction * with previous myocardial infarction * with occlusion of the left main or left circumflex coronary artery or with evidence of coronary collaterals to the region at risk on initial coronary angiography (at the time of admission) * with metallic implants (ferromagnetic material)
construction of theoretical model of medical treatment behavior of patients with chronic kidney disease

Conditions: Narrative Nursing; Maintenance Hemodialysis; Chronic Kidney Diseases

Summary: the impact of narrative nursing interventions on negative emotions, self-efficacy, quality of life in individuals undergoing maintenance hemodialysis

the objective of this study is to create a narrative nursing protocol using the "two-line system" approach to enhance the practice of narrative nursing.investigators applied this protocol during maintenance hemodialysis (mhd) treatment, with the aim of examining the impact of the interventions on negative emotions, self-efficacy, and overall quality of life of patients. by analyzing the data before and after the interventions, investigators aim to demonstrate how targeted narrative nursing measures can positively influence negative emotions, self-efficacy, and life quality of patients.

Eligibility criteria:
inclusion criteria: * patients diagnosed with esrd and treated with dialysis for more than 3 months; * patients aged ≥18 years old; * patients with complete clinical data; * patients who are clearly conscious and can accurately express their willingness; * patients who have signed informed consent and are willing to cooperate with the study. exclusion criteria: * patients with other serious systemic diseases, such as severe cardiovascular and cerebrovascular diseases, severe diabetes, etc.; * patients with mental disorder, such as cognitive or intellectual disability; * patients with a history of anxiety and depression; * patients with intermittent loss of consciousness or are unable to understand the questions in the questionnaire.

Keywords: self-efficacy negative emotions life quality
prognostic value of sarcopenia and nutritional status in early-stage non-small cell lung cancer

Conditions: Sarcopenia; Non Small Cell Lung Cancer; Malnutrition

Summary: growing evidence has confirmed that the prognosis of lung cancer is not only related to the stage of disease, but also to the physiological and psychological situation of the patients. malignant tumors are often associated with weakness and cachexia, leading to less physical activities and worse moods. however, few studies that have attempted to investigate the impact of nutritional status on the prognosis of nsclc. existing applications of nutritional scoring systems in early-stage of nsclc are very limited. therefore, this study aims to observe the correlation between nutritional status and the prognosis of patients with early-stage nsclc, to clarify the value in predicting the overall survival rate and progression-free survival rate of nsclc patients, and to offer evidence for alleviating the social and economic burden of nsclc.

the prognosis of lung cancer is not only related to the stage of disease, but also to the physiological and psychological situation of the patients. malignant tumors are often associated with weakness and cachexia, leading to less physical activities and worse moods. however, few studies that have attempted to investigate the impact of nutritional status on the prognosis of nsclc. existing applications of nutritional scoring systems in early-stage of nsclc are very limited. therefore, this study aims to observe the correlation between nutritional status and the prognosis of patients with early-stage nsclc, to clarify the value in predicting the overall survival rate and progression-free survival rate of nsclc patients, and to offer evidence for alleviating the social and economic burden of nsclc.

Eligibility criteria:
inclusion criteria: * the patients with non-small cell lung cancer diagnosed by cytology or pathology meet the standards of clinical diagnosis and treatment guidelines for lung cancer of chinese medical association (2018 edition) * tnm staging diagnosis of lung cancer meets the stage ia-iiia exclusion criteria: * severe heart failure, acute progressive pulmonary inflammation, acute liver and kidney dysfunction in recent 2 weeks * incomplete clinical and follow-up data or disagreement or inability to conduct regular follow-up ct imaging evaluation * a history of other malignant tumors and related tumor chemotherapy within half year, and previous history of radiotherapy * unable to walk, fail to complete the walking test, and the risk of fall down * unable to complete bia examination due to pacemaker implantation and other reasons * withdraw from the study for any reasons
study of neuromuscular electrical stimulation to increase spontaneous physical activity in obesity patient

Conditions: Obesity; Number of Steps Per Day < 7000

Summary: the study was designed to test the following hypotheses: main objective: to compare the level of spontaneous physical activity at 3 months after re-entrainment by multi-site electrical stimulation (m-es), measured by actigraphy over 7 days, compared to conventional care (lifestyle and dietary advice and placebo (simulated) electrostimulation) (control arm). secondary objectives: to compare the metabolic, inflammatory, cardiovascular and functional parameters, physical activity, quality of life and quality of sleep, at 3 months and at 2 years in the two groups. design: we will conduct a multicenter controlled study vs. reference care with randomization into two parallel groups and double-blind (placebo electrostimulation). patients will have the es material available at home and will be supervised by monthly visits over 3 months and by telephone follow-up for two years. the study size calculation is based on physical activity, the percentage of lean body mass and arterial stiffness measured in the obex study (nct01155271). this project will determine whether the training strategy is effective for increasing physical activity and/or in inducing significant metabolic and cardiovascular effects in these patients after 2 years. in addition, it provides a solid base of investigation for the study of the interactions between muscle contraction and cardio-metabolic health with greater precision.

obesity and sleep apnea syndrome lead to metabolic troubles and increasing cardiovascular risk. furthermore, both diseases are associated with reduced exercise tolerance. for many patients with morbid obesity, the implementation of physical activity programs remains difficult for several reasons including the level of disability and psychosocial causes (the scrutiny of others, depression and poorly adapted equipment). main hypothesis: neuromuscular electrostimulation is a way to increase spontaneous physical activity (pa) in treated apneic obese patients with low spontaneous physical activity

Eligibility criteria:
inclusion criteria: * obese patients with bmi \> 35 kg/m² * continuous positive airway pressure (cpap) treatment and \> 4h observance per night to the patient with osas (obstructive sleep apnoea syndrome) * patients who give written consent * patients who subscribed social insurance exclusion criteria: * cardiovascular or respiratory failure discovered at the moment of the inclusion in the study * contraindication to exercise * pregnant or breast-feed woman * patients under guardianship * imprisoned patients
evaluate the efficacy and safety of glaucoma implant in primary open angle glaucoma

Conditions: Glaucoma

Summary: the objective of this study is to evaluate the efficacy and safety of glaucoma device in the treatment of primary open-angle glaucoma.

a prospective, randomized, single-blind, positive control design was used to study primary open-angle glaucoma. eligible subjects were screened and randomly assigned to the experimental group and the control group.

Eligibility criteria:
inclusion criteria * patients with a clinical diagnosis of primary open-angle glaucoma (poag) who could undergo minimally invasive glaucoma surgery (migs) as judged by the investigator.

Keywords: glaucoma implant
neuromuscular block monitoring during monitored thyroidectomy

Conditions: Thyroid Surgery

Summary: titration of neuromuscular block (nmb) plays a key role in intraoperative recurrent laryngeal nerve monitoring during thyroid surgery. aim to titrate sugammadex dose based on neuromuscular block degree as a surgeon friendly protocol with high intraoperative neuromonitoring (ionm) quality.


Eligibility criteria:
inclusion criteria: * elective monitored thyroidectomy exclusion criteria: * previous thyroid surgery * preexisting vocal cord palsy

Keywords: intraoperative neuromonitoring (ionm) thyroid surgery neuromuscular block (nmb)
calculator predicts early mortality post hepatocellular carcinoma resection

Conditions: To Predict Early Post-hepatectomy Mortality for HCC

Summary: using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma. the user-friendly tool with 6 preoperative predictors demonstrated excellent accuracy. the freely available calculator may help identify high-risk patients and reduce futile liver resection for hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: adults (age ≥18 years) who underwent curative-intent hepatectomy for newly diagnosed hcc. hcc diagnosis was confirmed histopathologically. exclusion criteria: patients undergoing emergency hepatectomy for tumor rupture, as well as individuals with recurrent hcc, and those with missing survival data or less than 90 days of follow-up were excluded.

Keywords: hepatocellular carcinoma hepatectomy survival morbidity futile surgery