combination pet with 18f-fluorodeoxyglucose (18f-fdg) and 18 f-choline in patient with hcc

Conditions: Hepatocellular Carcinoma

Summary: the objective of this protocol is to obtain a better match between the actual staging and the proposed treatment in order to avoid inadequate treatments at risk of complications. in patients with hcc classified as bclc a to c, the combination of 18f-fdg and 18f-fluorocholine pet- tomodensitometry (tdm) with conventional imaging would clinically significantly modify the therapeutic strategy initially planned by conventional imaging alone. this change in therapeutic strategy would be from curative to palliative treatment or from loco-regional palliative to systemic palliative treatment. 18f-fdg and 18f-fluorocholine pet-ct scans will be performed after inclusion of the patient in the study and prior to multidisciplinary consultation meeting for treatment discussion.

hepatocellular carcinoma (hcc) is one of the leading causes of death from cancer worldwide, developing on cirrhosis in 90% of cases. the prognosis of patients with hcc remains poor with an overall survival of around 10% at 5 years for all tumor stages combined. the diagnosis of hcc relies on non-invasive conventional imaging criteria (computed tomography \[ct\] and/or magnetic resonance imaging \[mri\]) and/or histology. conventional imaging (liver ct and/or mri and lung ct) enables hcc staging according to the barcelona clinical liver cancer (bclc) system, linking each stage to therapeutic modalities. accurate staging with reliable imaging methods is therefore crucial to determine the best treatment strategy. the principal objective is to demonstrate that the identification of new tumor lesions by an experimental procedure combining 18f-fdg and 18f-fluorocholine pet-ct scans in patients with hcc, modifies the initially planned therapeutic strategy of a curative treatment palliative treatment, from locoregional palliative treatment to systemic palliative treatment.

Eligibility criteria:
inclusion criteria: * patients\> 18 years old * first diagnosis of hcc (no previous treatments received) * diagnosis of hcc according to the european association for the study of the liver (easl) 2012 criteria by "non-invasive" imaging on cirrhosis or by histology on cirrhosis or non-cirrhotic liver * bclc tumor stage a to c (excluding bclc c with extrahepatic metastases) according to conventional imaging * will be able to have a pet scanner within 4 weeks after the inclusion visit * ability to stay 20 minutes longer for pet-ct scans * need for oral, intra-uterine or mechanical contraception for women of childbearing age * written consent for participation in the study * having medical insurance coverage exclusion criteria: * patients classified bclc stage 0 (single hcc less than 2 cm) * patients classified as bclc stage c with extrahepatic metastases * decreased cirrhosis (child pugh c) and / or patients with eastern cooperative oncology group (ecog) performance status 2 to 4 not candidates for liver transplantation * uncontrolled diabetes (defined by blood glucose\> 1.7 g / l at the time of inclusion) * hypersensitivity to 18f fluorocholine or 18f-fdg or any of the excipients * creatinine clearance \<40 ml / min * contraindication to mri: pacemaker or implantable cardiac defibrillator not compatible with mri, neurostimulator, cochlear implant, intracerebral ferromagnetic vascular clip, intraocular or cerebral metallic foreign bodies, insulin pump * pregnant or lactating woman * patient under tutorship or curatorship or safeguard of justice * known allergy to iodine * patient deprived of liberty by judicial or administrative decision * patients with care "state medical aid"

Keywords: positron emission tomography 18f-fdg 18 f-fluorocholine