Kornimate/medical-research-clean huggingface dataset:
efficacity assessment of prevadh® in adhesion prevention in gynaecologic surgery

Conditions: Uterine Fibroids; Fertility Disorders

Summary: the purpose of this study was to evaluate clinically the efficacy of the prevadh® film in the prevention of adhesions in gynaecologic surgery, and to assess post-operative complications related to adhesions and pregnancy rate after myomectomy by open surgery.

this study was addressed to patients having an immediate or differed pregnancy desire and presenting a symptomatic or asymptomatic fibroma being able to interfere with fertility. * the primary end point was the assessment of adhesion rate to the uterine surgical sites during a laparoscopic second look performed 10 to 20 weeks post-surgery. * the secondary end points were the assessment, throughout a 3 years follow-up period, of: * pregnancy rate, * adverse events related to adhesions, * adnexal adhesions according to american fertility society score, * abdomino-pelvic adhesions according to the modified american fertility society score.

Eligibility criteria:
inclusion criteria: * symptomatic(s) or asymptomatic(s) uterin(s) fibroma(s) being able to interfere with the fertility by the patient who having an immediate or differed desire of pregnancy. * size: diameter ≥ 6 cm at echographia (for the highest diameter) * location interstitial and / or subserosa * planned laparotomic surgery * negative pregnancy test within 48 hours of surgery * signed inform consent exclusion criteria: * history of abdomino-pelvic surgery (except appendicectomy - cesarotomy) * pre-operative embolization * endometriosis stage \>1 (american fertility society classification ≥ 5) * pregnant patient * diabetes * chronic corticotherapy / immuno-supressor or immuno-modulator drugs * previous analog lh-rh drug therapy for the uterine myoma

Keywords: myomectomy adhesion prevention pregnancy rate
a study to learn about the long-term safety of higher doses of nusinersen (biib058) given as injections to participants with spinal muscular atrophy (sma) who took part in an earlier nusinersen trial (onward)

Conditions: Muscular Atrophy, Spinal

Summary: in this study, researchers will learn more about the use of nusinersen (biib058) in participants with spinal muscular atrophy (sma). this study is an extension study and will enroll only those participants who have completed treatment in the parent study, 232sm203. the main goal of the study is to learn about the long-term safety of nusinersen. the main questions researchers want to answer are: * how many participants have adverse events and serious adverse events during the study? * how do the results of electrocardiograms (ecgs), vital signs, and laboratory tests including blood and urine tests change after treatment? * how many participants have a low platelet count after treatment? * how many participants had a change in the time it took for their heart to recharge between beats after treatment? * how does each participant's height and other measures of growth change after treatment? * how much do the results of neurological exams that check movement, reflexes, and brain function change after treatment? researchers will also learn about the effect of nusinersen on mobility using various tests. they will study body movements, reflexes, balance, and coordination. they will also record if participants need help with breathing. the 232sm302 study will be done as follows: * participants will be screened to check if they can join the study. * participants will receive their 1st dose of nusinersen in this study about 4 months after their final dose in the parent study. * each participant will receive nusinersen once every 4 months during the treatment period. * nusinersen will be given through a lumbar puncture, which involves injecting the drug into the fluid around the spinal cord in the lower back. * the treatment period will last for up to 64 months (1921 days). * there will be a follow-up safety period that lasts from 4 to 8 weeks. * in total, participants will have up to 19 study visits. participants will stay in the study for close to 6 years.

the primary objective of this study is to evaluate the long-term safety and tolerability of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (sma) who previously participated in study 232sm203 (nct04089566). the secondary objective of this study is to evaluate the long-term efficacy of nusinersen administered intrathecally at higher doses to participants with sma who previously participated in study 232sm203 (nct04089566).

Eligibility criteria:
key inclusion criteria: * completed the day 302 visit in study 232sm203 (nct04089566) in accordance with the study protocol key exclusion criteria: * treatment with another investigational therapy or enrollment in another interventional clinical study * treatment with an approved therapy for sma after the day 302 visit of study 232sm203 (nct04089566) note: other protocol defined inclusion/exclusion criteria may apply.
plasma trimethylamine n-oxide elevation induced by l-carnitine supplementation and insulin resistance

Conditions: Insulin Resistance

Summary: the primary aims of the current study: * using l-carnitine supplementation modulate the level of plasma trimethylamine n-oxide to assess its effect on circulating cytokines related to diabetes and metabolic syndrome; * using simulated night-shift work intervention as a stress factor, explore the effect of circulating metabolites on insulin sensitivity the secondary aim is to evaluate the effect of carnitine supplementation on gut microbiome composition.

subjects will be randomly divided in two groups: supplemented by l-carnitine 2g/day for 12 weeks, and placebo group receiving leucine in identical gelatine capsules. subjects who successfully complete the protocol will be divided into four subgroups - two with a changed circadian cycle and two controls (supplemented and placebo). subgroups with a changed daily cycle will be able to sleep between 8:00 and 17:00 for four consecutive days, while during the night they will stay active in the laboratory. the oral glucose tolerance test (ogtt) will be performed before and after the circadian cycle modification. glucose levels will be monitored by freestyle libre sensor. moreover, the activity of the participants will be monitored by wearable activity trackers. before supplementation, as well as before circadian cycle modification and after finishing the whole experimental procedure, fasting blood samples will be collected for determination of plasma trimethylamine n-oxide (tmao), trimethylamine (tma), carnitine (free and acyl derivatives), protein markers of diabetes and inflammation. moreover, the stool samples will be collected before and after 12 weeks of supplementation, to determine the composition of the gut microbiome. in addition diet of participants will be monitored.

Eligibility criteria:
inclusion criteria: * healthy volunteers, * must be able to swallow tablets exclusion criteria: * smokers, * cardiovascular disease * liver disease * kidney disease * gastrointestinal disorders (including stomach ulcers and erosions) * diabetes
evaluation of professional attitude, job satisfaction and burnout levels of physiotherapists

Conditions: Health Personnel Attitude; Job Satisfaction; Professional Burnout

Summary: our study was planned to investigate the professional attitudes and satisfaction levels of physiotherapists. it has affected each professional group in different ways. the effects on health workers such as doctors and nurses have been studied in various studies. however, there are no studies on the effects on physiotherapists. after individuals start their profession in time, they develop an attitude towards their profession through cognitive and emotional orientations. level of interest in the profession, academic education activities related to the profession, working places, the institution where they work, the level of professional satisfaction of physiotherapists determinant factors of the disease. this study is a prospective questionnaire study. a questionnaire created through google forms the survey will be conducted by reaching physiotherapists. the survey will start after ethics commission permission is obtained. age, gender of individuals, year of graduation, level of education, marital status, institution, position/task, occupation of the manager of the organisation, most difficult patient group, the professional field he/she feels most deficient in, the number of training-courses he/she has taken related to the profession after graduation, after graduation the number of congresses-seminars-symposiums related to the profession, the status of following current developments will be questioned; attitude towards physiotherapy profession scale, minnesota job satisfaction scale, motivation feedback questionnaire, maslach burnout scale will be applied 1 time. the data will be analysed with spss 21.0 (spss inc., chicago, illinois, usa).


Eligibility criteria:
inclusion criteria: to have a bachelor's degree in physiotherapy and rehabilitation to be actively practicing the profession of physiotherapist in any institution exclusion criteria: graduated but not working as a physiotherapist.
tele-nursing follow-up after open heart surgery

Conditions: Open Heart Surgery; Tele-nursing

Summary: introduction: failure to follow-up patients by healthcare professionals after discharge may increase the development of anxiety and complications in patients. aim: the aim of this study is to determine the effects of tele-nursing method to patients who have undergone open heart surgery (ohs) after discharge on anxiety and some other complications. material and methods:this quasi-experimental randomized controlled study, which was conducted in a private hospital between november 2020 and april 2021, included 75 patients, 38 from the intervention (ig) and 37 from the control group (kg). ig and cg patients were provided routine treatment and care. in addition to the ig, training and counselling were provided at least four times by phone calls between the first week after discharge and the end of the first month. descriptive form and state-trait anxiety inventory (stai-s and t) were administered to all patients before discharge, and stai-s was administered at the end of the first month after discharge. post-discharge complications were evaluated by medical doctor in both groups. these data, number of hospitalization and readmission rates were obtained from hospital records.


Eligibility criteria:
inclusion criteria: * eighteen years and older, * able to speak and understand turkish, * without hearing, comprehension, vision and speech problems, * open heart surgery for the first time, * those who were not diagnosed with depression or anxiety disorder before surgery and didn't use medication for this purpose, * having a mobile phone that can take photos by herself/himself or her/his attendants, * no serious complications to delay hospital discharge, * patients who volunteered to participate were included in the study. exclusion criteria: patients who wished to withdraw from the study after volunteering were excluded from the study.

Keywords: anxiety complication readmission hospitalization
effects of kendall exercise vs gong's mobilization on pain, range of motion, function, and strength in cases with ucs

Conditions: Syndrome, Down

Summary: the effectiveness of kendall exercise vs. gong's mobilization for alleviating pain with improvment in range of motion, function and strength in cases with upper cross syndrome, assessed by dividing 44 patinets in two groups as group a (n=22) was treated with kendall exercises and group b (n=22) managed by gong's mobilization. vas, ndi, spadi, goniometer and dyanometer were used for assessing primary and secondary outcomes in patients.


Eligibility criteria:
inclusion criteria: * adults aged 45-65 years old * both genders * diagnosed with upper cross syndrome (ucs) * rounded shoulders * forward head posture * tightness in the pectoralis major and minor muscles 7. weakness in the lower trapezius and rhomboid muscles * reporting neck pain, shoulder pain, or headaches exclusion criteria: * history of neck or shoulder surgery or trauma * presence of other musculoskeletal conditions affecting the cervical spine or shoulder girdle * inflammatory conditions such as rheumatoid arthritis or gout * neurological conditions affecting upper limb function * pregnancy * uncontrolled cardiovascular or respiratory conditions * contraindications to manual therapy
the paws (pedometer and walking study)

Conditions: Intermittent Claudication

Summary: the literature has shown that supervised exercise programs for patients with pad and who report intermittent claudication (ic) have improved health outcomes, but this is not locally available. introducing the use of a pedometer may act as a method to encourage patients to continue on their independent exercise regimen. there is very little literature which has examined the effectiveness using pedometers as a measure of compliance within this population.

it has been established that exercise therapy has a central role in the management of peripheral arterial disease. such treatment should be comprised of intermittent walking of sufficient distance to induce significant discomfort, and be carried out over a period of at least several months. supervised exercise training utilizing intermittent treadmill walking is a well-validated treatment for claudication. most prospective randomized single site studies have reported significant improvement in walking distance following supervised exercise training but not with non-supervised regimens. furthermore, this has been acknowledged in both the current aha/acc 'guidelines for the management of patients with peripheral arterial disease', which recommends supervised exercise training as an initial treatment modality with a class 1a level of evidence (highest), as well as in the transatlantic intersocietal consensus, which provides an 'a' categorical recommendation. in spite of these peer-reviewed, published recommendations, supervised exercise training remains little used, expensive, not reimbursed by ontario health insurance plan, and therefore is rarely available to patients with claudication in ontario. the purpose of this multicentre study is to examine whether the use of a pedometer enhances patient compliance with walking as compared to usual care.

Eligibility criteria:
inclusion criteria: * males or females with a diagnosis of pad (abi \< 0.9) who report symptoms of ic, * independent with ambulation (assistive device is permitted) and living independently, * no previous vascular surgical interventions, * fluency in english is preferable but not required, * patients need to be willing to return for monthly assessment. exclusion criteria: * previous vascular surgical intervention, * non-ambulatory, * unstable cardiac status (cardiac event \< 6 months), * cognitive difficulties, * unwilling to engage in regular exercise
prostate biopsies with target lesion on mri

Conditions: Prostate Cancer

Summary: our objective is to search for clinical, biological and imaging element that would better define the patient population that could benefit from targeted prostate biopsies only (from a cohort of patients who had targeted and non-targeted prostate biopsies).


Eligibility criteria:
inclusion criteria: * age \> or = at 18 years old * prostatic mri performed at the montpellier university hospital * realization of targeted prostate biopsies (by fusion of mri - ultrasound images) and non-targeted biopsies exclusion criteria: * pre-biopsy mri performed outside of the montpellier university hospital * mri with artefacts * not performing 12 non-targeted prostate biopsies

Keywords: targeted prostate biopsy non-targeted prostate biopsy mri prostate biopsy
effect of acupressure applied before cystectomy on preoperative anxiety level

Conditions: Anxiety; Hemodynamic Instability

Summary: this randomized controlled study evaluates the effect of acupressure application on the anxiety level patients undergoing cystectomy surgery. the hypothesis of this study is that acupressure reduces anxiety levels and stabilizes hemodynamic parameters.

in the study, 60 patients will randomly assigned to acupressure and placebo acupressure groups. to the acupressure group (n = 30), an average of 15 minutes will be applied to the ht7 (heart), li4 (liver) and ex-nh3 (the point between the two eyes). in the placebo acupressure group (n = 30), the points 1.5 cm away from the ht7, li4, and ex-nh3 points will be applied for an average of 15 minutes.

Eligibility criteria:
inclusion criteria: * agreeing to participate in the research (signing the informed consent form), * conscious and cooperative * speaks and understands turkish, * 18-65 years old, * before surgery, * stable general condition, * no sensitivity in the area where acupressure/placebo acupressure will be applied, * 15 july 2022 - 15 july 2023 hospitalized in the urology clinic, * no active covid-19 infection, * patients without any psychiatric diagnosis will be included. exclusion criteria: * those who do not agree to participate in the research (who do not sign the informed consent form) * conscious and uncooperative, * not speaking or understanding turkish, * not between the ages of 18-65, * no surgical intervention planned, * the planned emergency surgical intervention, * unstable general condition, * sensitivity in the area where acupressure/placebo acupressure will be applied, * active covid-19 infection, * 15 july 2022 - 15 july 2023 who did not stay in the urology clinic, * patients with current psychiatric diagnosis will not be included in the study.
optimizing prescribing decisions for hospitalized older adults with chronic conditions

Conditions: Prescribing Decisions; Diabetes; Multimorbidity; Hypertension; Geriatrics

Summary: the goal of this pilot clinical trial is to learn if providing a clinical decision framework for managing older adults chronic conditions during hospitalization to inpatient clinicians improves clinicians' ability to individualize chronic condition prescribing decisions for hospitalized older adults (65 and older). the main questions it aims to answer are: * will the clinical decision framework lead to clinicians having greater confidence to individualize discharge prescribing? * will clinicians using the framework discharge make fewer changes to hospitalized older adults with home diabetes and hypertension medications than they did prior to receiving the framework? * will older adult patients of participating clinicians will report fewer gaps in understanding of medication changes after the clinician is exposed to the framework? researchers will compare participating clinician survey responses and prescribing records from before and after an educational session presenting the clinical decision framework. participants will be asked to * attend a one-time educational session on the clinical decision framework * complete 2 electronic surveys, one before and one following the educational session. * agree for researchers to contact their patients, in order for patients to complete a one-time phone survey about changes made to home medications during hospitalization and quality of communication from the hospital team.


Eligibility criteria:
clinician participants: inclusion criteria: 1. attending clinicians who practice on the general medicine or hospital medicine service at upmc presbyterian, upmc montefiore, upmc shadyside, upmc mercy, or upmc magee-women's hospital campuses. 2. practicing on the general medicine or hospital medicine service. this population may include physicians with training in general internal medicine, hospital medicine, family practice, internal medicine subspecialities, as well as advance practice clinicians. exclusion criteria: 1. anticipating leaving current clinical position within next 3 months 2. less than 4 weeks of inpatient attending service scheduled within 3 months of recruitment patient participants: inclusion criteria: 1. adult aged 65 years or older who are hospitalized under the care of a participating clinician and discharged home. 2. eligible patients must recieve at least one cardiometabolic medication change at hospital discharge (can include new medication starts, stops, or dose changes). cardiometabolic medications include any class of antihypertensive, lipid lowering, anti-platelet, or glucose lowering medications regardless of indication for use. exclusion criteria: 1. incapacity for informed consent / unable to answer survey questions due to cognitive impairment 2. enrolled in hospice care

Keywords: prescribing hypertension diabetes geriatrics polypharmacy multimorbidity hospital medicine
postdural puncture headache after spinal anesthesia for cesarean section

Conditions: Headache

Summary: post-dural puncture headache (pdph) is a potential and debilitating complication of spinal anesthesia in pregnant patients undergoing caesarean sections (cs), with a reported incidence of 0.5%-2% .

various methods for the management of pdph are present including proper hydration, maintaining a supine posture, caffeine, paracetamol, nonsteroid anti-inflammatory drugs (nsaid), theophylline, opioids like morphine and fentanyl, with the only clearly effective treatment being the epidural blood patch. glass particle contamination is known to occur on opening single-dose drug ampoules. although supporting data are lacking, intrathecal drug administration during subarachnoid blocks and chemotherapy with glass particle contamination is potentially hazardous,

Eligibility criteria:
inclusion criteria: * parturient with american society of anesthesiologists (asa) class i or ii * age: 20-45 years old * a full-term pregnant female undergoing elective cesarean section under spinal anesthesia exclusion criteria: * contraindications to regional anesthesia (coagulopathy, infection at the needle insertion site) * history of migraines or persistent headache * known hypersensitivity to local anesthetics * body mass index (bmi \> 35 kg/m2) * hypertensive disorders of pregnancy * emergency cesarean section * cardiorespiratory, hepatic, or renal impairment * history of a cerebrovascular accident, neurologic or psychological disorders * uncontrolled hypertension * spinal column surgery, chronic opioid consumption * patients with more than one single attempt and patients with blood loss over 1000 ml who will need additional fluid supplementation or blood transfusion * patient refusal