Kornimate/medical-research-clean huggingface dataset:
evaluation of sensitivity with and without sonic activation of a desensitizing gel before in office bleaching in adults

Conditions: Dentin Sensitivity; Tooth Bleaching

Summary: this randomized, controlled clinical trial, triple-blind, split-mouth type was conducted aiming to assess the absolute risk of sensitivity with and without sonic activation of a desensitizing gel previously to the in-office bleaching in adults.

this clinical trial evaluated the effect of sonic activation of a desensitizing gel on the occurrence of sensitivity associated with office bleaching. for this, 31 patients had their anterior superior teeth divided into right and left, according to the sonic activation (as) or not (ss) of the desensitizer. prior to bleaching, a desensitizing gel containing 5% potassium nitrate and 2% sodium fluoride (desensibilize kf2%, fgm dental products,sc, brazil) was applied. sonic activation was performed with a sonic device (smart, fgm dental products, sc, brazil) at the 170 mhz frequency. a hydrogen peroxide gel (whiteness hp maxx, fgm dental products, sc, brazil) was used in two whitening sessions. it was also performed, evaluation of the presence of cracks in enamel, through transillumination. the color change was verified using two color scales and a spectrophotometer. the dental sensitivity was recorded through a sensitivity diary answered by the patient, in the period up to 48 hours after each bleaching session. the absolute risk of tooth sensitivity was compared using the mcnemar test (= 5%). the color change was analyzed from the variation of units of scale vita (sgu) and through the value of δe, which were compared through student t test (α = 5%).

Eligibility criteria:
inclusion criteria: * patients had at least six upper anterior teeth free of caries and restorations on the vestibular surface, and at least one central or canine incisor showing a2 or darker coloration, evaluated in comparison with a visual scale of color orientated by the value of the teeth (vita classical, vita-zahnfabrik- germany). exclusion criteria: * users of fixed orthodontic appliances, pregnant or lactating, with the presence of severe intrinsic stains on the teeth (spots on the use of tetracycline, fluorosis and depolluted teeth), who were taking any medication with action anti-inflammatory and antioxidant, using desensitizing dentifrice and participants with previous history of dental sensitivity or any associated pathology (bruxism, gingival recession, non-carious lesion with dentin exposure).

Keywords: tooth sensitivity tooth bleaching desensitizing agent sonic vibration
type 1 diabetic post prandial glycemia evaluation using an algorithm

Conditions: Type I Diabetes

Summary: the aim of this study is to demonstrate the efficacy of an algorithm to anticipate the post prandial glycemic profile in type i diabetic patient.


Eligibility criteria:
inclusion criteria: * type 1 diabetes * ≥ 18 years old * hb1ac\<12% exclusion criteria: * patient without continuous glucose monitoring system * disease other than diabetes (bulimia, anorexia...) * dialysis patient * known history of drug or alcohol abuse * patient under judicial protection * person deprived of liberty * pregnant, parturient or breastfeeding woman * patient in psychiatric care * patient admitted to a health or social institution for purposes other than research * any reasons that might interfere with the evaluation of the study objectives

Keywords: type i diabetes hyperglycemia post prandial glycemia algorithm
randomized phase ii trial of dose dense docetaxel in n+ breast cancer

Conditions: Node Positive Breast Cancer

Summary: to screen a dose-dense arm to be used in a future large scale phase iii trial. primary endpoint is safety; secondary endpoints are disease free survival and overall survival. a total of 100 patients were included.


Eligibility criteria:
inclusion criteria: * patient with histologically proven breast cancer * surgical resection performed with clear margins (r0 resection) * at least 1 histologically proven involved axillary node * er + or er- * interval between surgery (2nd surgical procedure in case of multiple procedures) and randomization inferior to 60 days * aged over 18 years, and more than 10-year life expectancy * ecog performance status 0-1 * signed informed consent form prior to randomization exclusion criteria: * bilateral breast cancer * inflammatory breast cancer * personal history of breast cancer * immunohistochemical only node involvement * intraductal breast cancer * distant metastases * contraindication to any drug contained in the chemotherapy regimens * any serious active disease or co-morbid medical condition including recent history of severe sepsis and digestive inflammatory disease * poor renal function (creatinin level \> 120 micromol/l), poor hepatic function (total bilirubin level \> 1 unl), transaminases \> 2.5 unl) * poor bone marrow reserve as defined by neutrophils \< 1.5 g/l or platelets \< 100 g/l; hemoglobin \< 10 g/dl * poor contractile cardiac function (lvef \< 50%) * coronary disease * any history of cancer during the last 5 years, with the exception of basal cell carcinomas or stage 0 (in situ) cervical carcinoma * pregnancy or breast feeding * absence of contraception in non menopausal women * adult patient unable to give informed consent because of intellectual impairment * concomitant participation to another trial
initial performance of a daily disposable contact lens featuring molded marks

Conditions: Refractive Error

Summary: the purpose of this study is to evaluate the impact of back surface molded marks (mm) applied to delefilcon a contact lenses as measured by the incidence of ocular discomfort device-related adverse events with dailies total1® multifocal contact lenses with molded marks (dt1 mf mm) and current dailies total1® multifocal contact lenses (dt1 mf).


Eligibility criteria:
inclusion criteria: * must sign an informed consent document; * current wearer of commercial dailies total1® contact lenses; * have spectacles in current prescription available to be worn in conjunction with the investigational product; * manifest astigmatism less than or equal to 0.75 diopter (d) (at screening) * best corrected distance visual acuity (bcva) greater than or equal to 20/25 in each eye; * other protocol-specified inclusion criteria may apply. exclusion criteria: * eye injury in either eye within 12 weeks prior to study enrollment; * any anterior segment infection, inflammation, disease, or abnormality that contraindicates contact lens wear; * any use of systemic or ocular medications for which contact lens wear could be contraindicated; * history of herpetic keratitis, refractive surgery or irregular cornea; * a pathologically dry eye that precludes contact lens wear; * concurrent participation in a contact lens or contact lens care product clinical trial within the previous 30 days; * monocular (only 1 eye with functional vision); * other protocol-specified exclusion criteria may apply.
comparing postoperative pain following cox-2 and prostanoids expression

Conditions: Female Genital Disease

Summary: the purpose of this study is to compare postoperative pain following cox-2 and prostanoids expression in women who underwent laparoscopic surgery for female genital disease in order to evaluate the effect of cox-2 on local inflammation, cox-2 and prostanoids expression followed by exposure time to carbon dioxide(co2) gas, and degree of postoperative pain.

in women who underwent laparoscopic surgery for female genital disease, the effect of cox-2 on local inflammation was assessed by randomization, using the cox-2 inhibitor celecoxib and placebo, comparative evaluation of expression of cox-2 and prostanoids by pre/postoperative peritoneal biopsy and postoperative pain depending on gas exposure time

Eligibility criteria:
inclusion criteria: * female, age ≥ 20 years * patients with benign female genital disease who need laparoscopic surgery * patients with benign disease who can be treated by single port laparoscopy * patients who signed an approved informed consent exclusion criteria: * female, age \< 20 years * pregnancy * previous cancer history * patients who refuse to sign an informed consent * patients with benign female genital disease combined clinical peritonitis (ex. tubo-ovarian abscess, tubo-ovaritis, ruptured endometriosis) * patients with malignant female genital disease * patients who got surgery with multi-port laparoscopy * patients who are contraindicated with cox-2 inhibitors (liver disease, renal disease, active peptic ulcer, active gastrointestinal tract bleeding, ischemic heart disease, hyperkalemia)

Keywords: laparoscopic surgery cox-2 inhibitor celecoxib prostanoid
fempulse therapy for overactive bladder in women

Conditions: Urinary Bladder, Overactive

Summary: the purpose of this clinical trial is to investigate a new medical device treatment for overactive bladder (oab) in women.

the fempulse system is a vaginal ring intended to provide mild electrical stimulation to nerves that regulate bladder function. it is believed that stimulation of these nerves may help relieve the symptoms of oab.

Eligibility criteria:
inclusion criteria: * females 21 years or older with a diagnosis of overactive bladder * if of reproductive age, must use a reliable form of contraception exclusion criteria: * pregnant, was recently pregnant or is trying to conceive * has a metal pelvic implant or any electrically active implanted medical device * had a previous hysterectomy, pelvic radiation or pelvic cancer * has significant pelvic organ prolapse * had bladder treatment with onabotulinumtoxina in the previous 12 months * has a significant heart condition

Keywords: overactive bladder oab women neuromodulation bioelectronic medicine
effectiveness of mobile-health self management on quality of life of patients undergoing chemotherapy

Conditions: Cancer; Chemotherapy Effect; Quality of Life; Self Efficacy

Summary: the study will design and evaluate the use of mobile-health based self-management on self-efficacy and quality of life of patients undergoing chemotherapy.

the study will design and evaluate the use of mobile-health based self-management on self-efficacy and quality of life of patients undergoing chemotherapy.

Eligibility criteria:
inclusion criteria: * adult patients diagnosed with cancer * patients who use smart phone exclusion criteria: * patients with cancer with comorbidity
punch vs. drill tunnel use for anchor tunnel creation and correlation with post-operative pain

Conditions: Rotator Cuff Tears

Summary: to determine if different techniques used in the creation of suture anchor socket creation can influence post-op pain following rotator cuff repair.


Eligibility criteria:
inclusion criteria: a. patient's aged 18-80 years old with diagnosis of rotator cuff tear having failed non-operative management and being indicated for surgical intervention with use of suture anchors. exclusion criteria: 1. glenohumeral arthrosis 2. previous shoulder surgery 3. psychiatric diseasesmri 4. rheumatologic diseases 5. fibromyalgia 6. spine diseases
prevalence of preoperative dehydration in major elective urologic surgery and its impact on postoperative outcome

Conditions: Dehydration; Postoperative Nausea and Vomiting; Postoperative Complications

Summary: the primary objective of this study is to measure the prevalence of preoperative dehydration in elective major abdominal urologic surgery when we apply our daily standard operation procedures. secondary objectives are to assess the impact of preoperative dehydration on postoperative outcome. the hypothesis is that preoperative dehydration leads to more postoperative complications.

the information about the impact of preoperative dehydration on postoperative outcome is conflicting. one of the reported difficulties of the studies in this field is to get adequate power for statistical significance. the incidence of preoperative dehydration in different surgical populations has been reported in about one third of patients. the prevalence in the urologic population is not known. this is a monocentric observational study with no study intervention. the goal is to consecutively include all patients undergoing major urologic surgery during 365 days who meet the inclusion criteria to assess the prevalence of preoperative dehydration in elective major abdominal urologic surgery when the standard operation procedures of the university hospital bern are applied.

Eligibility criteria:
inclusion criteria: * \>18 years old * major elective urologic surgery i. prostate surgery ii. bladder surgery iii. kidney surgery iv. various laparotomies / laparoscopies (e.g. retroperitoneal lymphadenectomy) * standard procedure planned * standard perioperative management planned * informed consent exclusion criteria: * preoperative iv-fluids * pregnancy (which is a contraindication to this type of surgery per se) * inability to give informed consent (e.g. severe psychiatric disorder, dementia) * inability to complete the quality of recovery (qor) questionnaire * enrolment of the investigator, his/her family members, employees and other dependent persons
to assess immunogenicity of coronavirus disease 2019 (covid-19) vaccine in cancer patients receiving cancer treatment

Conditions: Breast Cancer; Lung Cancer; Melanoma (Skin)

Summary: this is a trial of prospective collection of serial blood samples after administration of covid-19 vaccine in patients with cancer who are receiving active cancer treatment, planned to start therapy with 14 days of consent, or have had stem cell transplant. cancer treatments and administration of vaccine are not controlled by the study.


Eligibility criteria:
inclusion criteria: * ability of participant or legally authorized representative (lar) to understand this study, and participant or lar willingness to sign a written informed consent * males and females age ≥ 18 years * patients with breast cancer, lung cancer, malignant melanoma or who have undergone stem cell transplant or chimeric antigen receptor (car) t cell therapy for a hematologic malignancy. other cancer types including hematologic malignancies may be allowed if they are receiving treatments outlined in section 4.1.4 * solid tumor patients and those with hematologic malignancies: currently receiving active anti-cancer therapy, or planned to start within 14 days, with intravenous cytotoxic chemotherapy (oral or intravenous), intravenous chemoimmunotherapy combination, immunotherapy alone, an oral cdk 4/6 inhibitor. (this does not apply to recipients of stem cell transplant and car t therapy) * therapy may be neo/adjuvant or for metastatic disease * eastern cooperation oncology group (ecog) performance status (ps) of 0-2 exclusion criteria: \* life expectancy of \< 12 months
sarcoma database at kfsh&rc

Conditions: Sarcoma Database

Summary: sarcoma database

sarcoma database

Eligibility criteria:
inclusion criteria: * patients with diagnosed sarcoma exclusion criteria: * patients with diagnosis other than sarcoma

Keywords: sarcoma database
closed sinus tenting using densah burs osteotomy versus conventional osteotomy in localized pneumatization

Conditions: Edentulous Alveolar Ridge

Summary: isolated sinus pneumatization after single tooth extraction indicate sinus lifting for proper implant placement. the conventional way of using osteotomes to elevate the sinus is annoying to patient and also does not give the needed amount of bone around the implant. introducing new intervention of densah burs helps increase bone gain around implant and decrease the patient discomfort.

the rehabilitation of the edentulous posterior maxilla using osseointegrated implants is often challenging due alveolar bone resorption, low bone density and maxillary sinus pneumatization. maxillary sinus lift is one of the most common surgical techniques used for increasing the available bone volume to place implants and restore function and esthetics. trans-crestal approach can be successfully adopted when residual bone height is at least 5 mm. osteotome sinus floor elevation was first in 1994, and proved to be less invasive, more conservative, less time consuming, and reduces postoperative discomfort to the patient. moreover, this technique was found to yield predictable results with success rates of at least 95%. osseodensification is a new surgical technique of biomechanical bone preparation performed for dental implant placement where bone is compacted and auto grafted into open marrow spaces and osteotomy site walls in outwardly expanding directions. it was reported that osseodensification increases the bone-implant contact, bone density, and primary stability. moreover, the insertion torque peak is directly related to implant primary stability and host bone density. furthermore, for every 9.8 n cm of torque increased, a reduction in failure rate of 20% in single-tooth implant restoration was observed. the objective of this study is to evaluate crestal sinus elevation using osseodensification versus osteotomy clinically and radiographically in terms of marginal bone loss, primary and secondary stability and bone gain around the implant.

Eligibility criteria:
inclusion criteria: * no inflamed sinus * minimum alveolar ridge height 5-6 mm * medical free * both genders males and females. exclusion criteria: * remaining alveolar ridge height is less than 5mm * patients should not have taken drugs, especially bisphosphonates or drugs altering bone metabolism, within 2 months before the inclusion in the study. * subjected to irradiation in the head and neck area less than 1 year before implantation. * patients having history of allergy to any drugs. * patients who have a history of any concomitant from a major known medical problem and/or ongoing pharmacologic treatments * untreated periodontitis. * poor oral hygiene and motivation. * uncontrolled diabetes. * pregnant or nursing. * substance abuse. * psychiatric problems or unrealistic expectations. * severe bruxism or clenching. * immunosuppressed or immunocompromised. * treated or under treatment with intravenous amino-bisphosphonates.

Keywords: densah burs osteotomes sinus tenting graftless
transversus abdominis plane catheter following kidney transplantation

Conditions: Pain, Postoperative; Kidney Transplant

Summary: continuous infusion of local anesthetic after kidney transplantation this is a phase iii, randomized, double-blinded, sham-controlled trial comparing the use of a continuous infusion of local anesthetic via transversus abdominis plane (tap) catheter to a saline infusion (sham) via tap catheter along with standard postoperative analgesia in patients undergoing kidney transplantation. patients will have a tap catheter placed at the time of kidney transplantation by the surgical team under direct vision. they are then randomized to a continuous infusion of local anesthetic or saline for 48 hours postoperatively. both groups will receive a standard postoperative analgesic regimen including a patient controlled analgesic (pca) pump and multimodal analgesics including acetaminophen and gabapentin.


Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form 2. stated willingness to comply with all study procedures and availability for the duration of the study 3. male, female, non-binary gender, aged \>18 years. 4. undergoing a kidney transplant (deceased or living donor) as treatment for stage 5 chronic kidney disease (glomerular filtration rate \< 15ml/min) either on dialysis, or approaching dialysis 5. no history of allergy to any local anesthetic. 6. agreement to adhere to lifestyle considerations (see section 5.3) throughout study duration exclusion criteria: 1. current use of opioid pain medications prior to kidney transplantation. 2. known allergic reactions to components of any local anesthetic medication. 3. prior local anesthetic systemic toxicity. 4. history of chronic pain undergoing current active treatment for the same. 5. age \<18 years (this analgesic approach has not been established in this population). 6. unable or unwilling to use iv pca pump for any reason (manual dexterity, cognitive impairment, patient choice etc.). 7. multi-visceral transplantation. 8. incision other than standard gibson incision. 9. unilateral or bilateral nephrectomy at time of kidney transplant. 10. advanced liver disease.
liwan eye study: the fourth follow-up

Conditions: Primary Angle-Closure Glaucoma

Summary: primary angle-closure glaucoma (pacg) is one of the major causes of blindness affecting more than 20 million patients worldwide. the goals of this observational cohort study are to investigate the 20-year incidence of pacg in chinese population aged 50 years and to develop prediction models for the long-term risk of progression from primary angle-closure suspect (pacs) to pacg.

primary angle-closure glaucoma (pacg) is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide, especially in east asia. primary angle-closure suspect (pacs), which is characterized by appositional angle closure, is the earliest stage of primary angle closure diseases and can finally progress to pacg. thus, identifying pacs eyes at risk of angle closure is crucial for its management. however, the natural history of progression from pacs to pacg and its prediction models are still limited in long-term longitudinal studies. meanwhile, visual impairment poses a significant global public health burden along with the accelerating trend of aging, it is imperative to further evaluate the visual impairment among the elderly population. the liwan eye study was a population-based study initiated in 2003. the decision to select liwan district for the survey was taken because of its stable, older population and a socioeconomic profile representative of guangzhou as a whole. at baseline, 1405 eligible subjects aged 50 years and older completed a comprehensive eye examination and a questionnaire interview regarding education, income, hypertension and diabetes mellitus. to improve the monitoring of pacs and prevent vision loss associated with pacg, the purposes of this observational cohort study are to investigate the 20-year incidence of pacg in chinese population aged over 50 years, develop prediction models that include eye characteristics, demographic features, ocular imaging characteristics, and genetic factors for the long-term risk of progression from pacs to pacg. moreover, we aim to investigate the 20-year change in visual impairment and associated factors.

Eligibility criteria:
inclusion criteria: * participants who have previously participated in the liwan eye study * individuals who sign an informed consent form voluntarily exclusion criteria: * none