Kornimate/medical-research-clean huggingface dataset:
association between ultrasound morphology of intestinal endometriosis nodules and symptom severity

Conditions: Endometriosis Rectum

Summary: association between the ultrasound appearance of deep bowel endometriosis and the frequency of pain

in order to improve the diagnostic power of the ultrasound method, it is important to evaluate the association between the ultrasound appearance of the nodule of intestinal deep endometriosis and the frequency of pain, thus assessing the prevalence of moderate or severe clinical symptoms, in patients with newly diagnosed intestinal deep endometriosis, according to the ultrasound morphology of the posterior deep endometriosis nodule proposed in the international deep endometriosis analysis group (idea) consesus.

Eligibility criteria:
inclusion criteria: * patients aged ≥18 years; * presence of posterior rectus intestinal deep endometriosis confirmed on tv ultrasound between 01/01/2018 and 30/06/2023; * informed consent obtained exclusion criteria: * virgo patients; * patients reporting intolerance to transvaginal ultrasound; * current or history of gynaecological oncology; * previous surgery of the sigma and rectum

Keywords: endometriosis ultrasound gynaecology
comparing mirror therapy rehabilitation device to conventional mirror therapy

Conditions: Stroke; Pain; Impaired Motor Function

Summary: this is a randomized controlled trial which will compare conventional mirror therapy with mirror therapy using the miraπ device which physically moves a patient's affected limb. this study will use two parallel groups: (1) receiving conventional mirror therapy as a part of the standard of care as conducted by the participant's clinical care team and (2) receiving mirror therapy with the miraπ device as conducted by study personnel with the oversight of the participant's clinical care team.


Eligibility criteria:
inclusion criteria: * participants currently accepted and cleared for rehabilitation in the inpatient rehabilitation unit by the rehabilitation medical director. * participants with paralysis or motor function problems of only one hand. * participants need mirror therapy because of their health condition. * participants' rehabilitation physician determined that mirror therapy would be appropriate for standard of care. * participants are able to memorize easy tasks, and able to follow instructions e.g., moving the healthy fingers. exclusion criteria: * participants who are not cleared physically or medically to participate in standard acute inpatient rehabilitation therapies by the rehabilitation medical director * participants who are not able to memorize easy tasks, e.g., moving the healthy fingers. * participants with spasticity of the affected hand (as assed by the occupational therapist) * minors * vulnerable populations
u.s. guided erector spinae block for postoperative pain management in paraumbilical hernia repair patients

Conditions: Regional Anesthesia

Summary: abdominal surgery is one of the most definitive and mainstay treatment options for abdominal pathologies in clinical practice. acute postoperative pain is a major challenge in the postoperative period. although opioids are commonly used for analgesia after paraumbilical hernia, they can lead to side effects, such as nausea and vomiting, constipation, pruritus, and life-threatening respiratory depression. regional anesthetic techniques are commonly used to prevent or minimize these side effects. the objective of this study is to assess the effectiveness of erector spinae plane block (espb) and standard medical (no block) pain management after paraumbilical hernia.


Eligibility criteria:
inclusion criteria: * age group : 18-60 years old * both genders * patient scheduled for paraumbilical hernia surgeries exclusion criteria: * allergy to medications used in this study * patient's refusal to participate in this study * recurrent cases * any complications to local blocks * emergency surgical procedures
study of rehabilitation therapy on patients after acute myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: the purpose of this study is to determine whether exercise rehabilitation can reduce mortality, reinfarction or heart failure of patients after acute myocardial infarction.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of st-elevated myocardial infarction * heart function class i-ii(killip classification) * agree to take cardiopulmonary exercise testing before discharge * signature of the informed consent document exclusion criteria: * history of myocardial infarction * acute myocardial infarction with severe complications(such as pulmonary edema, severe cardiac arrhythmia or cardiogenic shock) * atrial fibrillation * other severe diseases, such as hiv infection, malignant tumor or chronic diseases of liver, kidney or pulmonary * not be capable of exercise training

Keywords: st-elevated myocardial infarction exercise training rehabilitation
a first in human study of stt-5058, an antibody that binds apoc3

Conditions: Hypertriglyceridemia

Summary: a first in human study of stt-5058, an antibody that binds apoc3, investigating single and multiple ascending intravenous doses and ascending subcutaneous doses of stt-5058 in otherwise healthy volunteers with elevated triglyceride levels

the study is in five parts. part a is up to 6 single ascending intravenous dose cohorts of stt-5058 in otherwise healthy volunteers with trgs \>150mg/dl. part b is up to 4 multiple ascending intravenous dose cohorts of stt-5058 in otherwise healthy volunteers with trgs \>150mg/dl who will receive 3 doses at 2 week intervals. part c will recruit a single cohort of patient volunteers with trg \>200mg/dl who will receive 3 doses at 2 week intervals of stt-5058. part d will investigate up to 2 single ascending doses of subcutaneous stt-5058. part e will recruit a single cohort of otherwise healthy volunteers with trg \> 150mg/dl to receive 4 doses subcutaneously of stt-5058 over 4 weeks

Eligibility criteria:
inclusion criteria: * in good health * able to comprehend and willing to sign an icf and to abide by the study restrictions. * females will not be pregnant or lactating, and females of childbearing potential and males will agree to use contraception parts a, b and d * bmi between 18 and 35 kg/m2 inclusive * fasting triglycerides between 150 and 400mg/dl inclusive part c * fasting triglycerides between 200 and 400 mg/dl inclusive * fasting ldl-c between 70 and 160 mg/dl inclusive * bmi between 18 and 40 kg/m2 exclusion criteria: * significant history or clinical manifestation of metabolic, allergic, dermatological, hepatic, renal, haematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as determined by the investigator * confirmed (eg, 2 consecutive measurements) systolic blood pressure \>150 or \ 90 or \ 90 or \<40 beats per minute at screening, check-in, or prior to dosing on day 1. * history of alcoholism or drug/chemical abuse within 2 years prior to check-in. * participation in a clinical study involving administration of an investigational drug (new chemical entity) in the past 90 days or 5 half-lives (if known), whichever is longer, prior to dosing.
relationship between adipose tissue distribution and arterial stiffness in hfpef

Conditions: Heart Failure With Preserved Ejection Fraction; Arterial Stiffness; Lipid Disorder

Summary: heart failure with preserved ejection fraction (hfpef) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. however, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in hfpef patients.

before the 21st century, heart failure with preserved ejection fraction (hfpef) was considered as a disease with simple diastolic dysfunction, but after the 21st century, hfpef was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. however, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in hfpef patients.

Eligibility criteria:
inclusion criteria: 1. adult aged \>=18years old; 2. diagnosed with hfpef. diagnostic criteria including: 1. left ventricular ejection fraction ≥50%； 2. with the symptoms and/or signs of heart failure； 3. bnp≥35 pg/ml and/or ntprobnp≥125 pg/ml； 4. at least one additional criterion: relevant structural heart disease(lvh and/or lae) or diastolic dysfunction exclusion criteria: 1. lvef less than 45% at any time; 2. severe liver failure; 3/other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease; 4.primary pulmonary hypertension; 5.severe valvular disease of the left heart; 6.chronically bedridden or incapacitated; 7.age \<18 years old.
effect of different intensities of exercise on daily energy expenditure with physical activity in overweight boys

Conditions: Obesity

Summary: the main purpose of this study is evaluate the effect of different intensities of exercise (moderate vs. intense) on the daily energy expenditure in overweight adolescents.

the specific objectives are: 1. assess and quantify the existence of compensatory effect of exercise on subsequent physical activity. 2. compare the amount of daily physical activity in adolescents subjected to different protocols of training intensity.

Eligibility criteria:
inclusion criteria: overweight 6th and 7th grades students consent form signed by parents / tutors exclusion criteria: diabetes mellitus hypertension or reported cardiovascular disease

Keywords: physical activity energy expenditure compensatory mechanisms adolescent
prame immunohistochemistry as an adjunct for evaluating ambiguous melanocytic proliferation

Conditions: Melanoma

Summary: skin melanoma is a common form of skin cancer. its diagnosis is usually clinically suspected and then affirmed by histopathological examination. in some cases, the histopathological analysis of these lesions is equivocal, and the malignant or benign nature of the proliferation is difficult to determine with certainty. in these cases, the use of expensive ancillary tests, which are hardly accessible and take a long time to set up (fish - cgh-array), is usually required. anti-prame immunostaining, an inexpensive and readily available technic, has recently been described as highly sensitive and specific for diagnosing malignant melanocytic proliferations. knowledge on its utility for evaluating ambiguous melanocytic neoplasms remains limited. our study aims to improve the current body of knowledge on the utility of prame immunohistochemistry for evaluating challenging samples of melanocytic proliferation. the secondary objective is to determine the prame immunoreactivity profile for each histological subtype of melanocytic proliferations (spitzoid tumors, cellular blue nevi, dysplastic nevi ...)


Eligibility criteria:
inclusion criteria: * adult patient at the time of diagnosis (\> = 18 years). * histopathological diagnosis of "ambiguous melanocytic proliferation" or "atypical melanocytic proliferation" made between january 2016 and december 2020. * histological slides archived in the "crb" biobank available * formalin-fixed paraffin-embedded tissue block archived in the "crb" biobank available * informed patient exclusion criteria: * patient who has expressed opposition to participating in the study.

Keywords: immunohistochemistry histopathology
clinical study of curcumin in preventing postoperative adhesion of bilateral vocal cords

Conditions: Glottic Web of Larynx; Laryngeal Stenosis; Glottic Carcinoma; Laryngeal Leucoplakia; Laryngeal Polyp; Laryngeal Papilloma

Summary: to provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.


Eligibility criteria:
inclusion criteria: 1. patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically. 2. patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically. exclusion criteria: 1. patients with other laryngeal diseases. 2. patients with cardiac and pulmonary insufficiency. 3. patients unable to cooperate with the follow-up on time after surgery. 4. patients who refuse to sign the informed consent after notification. 5. patients who have a severe allergic disease or allergic history to a variety of drugs. 6. other circumstances that are not appropriate to be included in the clinical trial.

Keywords: curcumin
evaluation of mind-body educational program to enhance resiliency and reduce burnout in first year residents

Conditions: Stress

Summary: this prospective pilot study evaluated the benefits of a stress management and resiliency training program for residents (smart-r). the primary objective of this study is to determine whether the smart-r effectively reduces burnout and stress and enhances coping skills in first year residents. objective parameters (heart rate, galvanized skin response, sleep duration and quality, exercise and actigraphy) measured with the basis health tracking device will help correlate objective signs to subjective report of stress. the investigators' hypothesis is that the smart-r, a curriculum designed to teach first year residents (in the department of medicine and psychiatry) relaxation skills, will enhance residents' emotional and physical well being, reduce reports of stress, anxiety, depression, and physical complaints, as well as increase overall resiliency.

the smart-r has been developed by the benson-henry institute (bhi) of mind body medicine and is aimed at reducing the impact of stress through a variety of skill building exercises. the exercises incorporated into the program have been shown to improve physical symptoms, mood and wellbeing in medical patient populations. however, very little work has focused on healthcare providers, and there are no studies that look at mindfulness interventions for resident physicians specifically. participants enrolled will be invited to complete a set of questionnaire before and after participation in the program. the investigators will also collect continuous physiologic data using the basis peak health tracking device to correlate the physiologic data with self-report measures of stress.

Eligibility criteria:
inclusion criteria: * massachusetts general hospital first year resident in department of medicine or department of psychiatry * 21 years of age or older * consenting to participate in 3rp-1 exclusion criteria: -

Keywords: mind/body medicine 3rp stress management resident burnout
a trial evaluating the efficacy and safety of the sublingual sufentanil tablet 30 mcg for post-operative pain after abdominal surgery

Conditions: Post-Operative Pain

Summary: the purpose of this study is to compare the efficacy and safety of the sublingual sufentanil tablet (st) 30 mcg to the sublingual placebo tablet (pt) for the short-term management of moderate-to-severe acute post-operative pain in patients after abdominal surgery.


Eligibility criteria:
inclusion criteria (additional criteria not specified here): 1. patients who are scheduled to undergo one of the following procedures with general anesthesia or spinal anesthesia that does not include intrathecal opioids during the operation: * abdominoplasty * open tension-free inguinal hernioplasty (lichenstein repair with mesh) * laparoscopic abdominal surgery 2. patients classified as american society of anesthesiologists (asa) class i - iii (appendix i). 3. female patients of childbearing potential must be using an effective method of birth control at the time of screening visit 4. patients who are expected to have moderate-to-severe post-operative pain for at least 24 hours. exclusion criteria (additional criteria not specified here): 1. patients who have taken an opioid for more than 30 consecutive days, at a daily dose of more than 15 mg of morphine (or equivalent), within the past 3 months prior to surgery 2. patients who are currently taking monoamine oxidase inhibitors (maois) or have taken maois within 14 days of the first dose of study drug. 3. patients with current sleep apnea that has been documented by a sleep laboratory study or are on home continuous positive airway pressure (cpap). 4. patients who previously have had abdominoplasty or have had an inguinal hernia repair on the same side.
high-intensity interval training(hiit) on cardio-metabolic risk in school-age children

Conditions: Cardiovascular Syndrome, Metabolic

Summary: this study aims to evaluate the health promotion effects of high-intensity interval training (hiit) intervention on school-age children who are at high risk for cardiovascular disease (cvd), as well as the long-term adherence and acceptability of hiit in this population for future application.

evidence shows that physical activity is positively associated with cardiovascular and metabolic health in children and adolescents, including promoting lipid health, regulating blood pressure levels, and glucose metabolism. physical activity intervention for overweight or obese children can lower body mass index, total fat mass, and abdominal fat mass, and further prevent chronic diseases such as cardiovascular and metabolic diseases. high-intensity interval training (hiit) has been a recent research focus. previous studies have demonstrated that hiit can contribute to improving body composition, reducing visceral fat, and enhancing cardiovascular and pulmonary function. moreover, compared to other trainings, hiit is time-efficient and adaptable to various sports, thus leading to higher compliance. however, there has been a lack of evidence regarding the intervention effects of this exercise in overweight and obese children and adolescents, and whether it can impact or even reverse cardio-metabolic risks remains unknown. therefore, this intervention trial might have implications and practical significance on the feasibility of promoting hiit among this population.

Eligibility criteria:
inclusion criteria: * aged 7-18 years at baseline. * at least one of the following cardio-metabolic abnormalities: 1. prediabetes (impaired fasting glucose: 5.6 ≤ fasting blood glucose level ≤ 6.9 mmol/l; or impaired glucose tolerance: 7.8 ≤ blood glucose level after 2 hours postprandial ≤ 11.0 mmol/l). 2. lipid abnormalities (high-density lipoprotein cholesterol ≤ 1.04 mmol/l; or low-density lipoprotein cholesterol ≥ 3.37 mmol/l; or triglycerides ≥ 1.70 mmol/l, or total cholesterol ≥ 5.18 mmol/l). 3. elevated blood pressure (systolic/diastolic blood pressure consistently higher than the 90th percentile for gender, age, and height; or systolic/diastolic blood pressure ≥ 120/80 mmhg). * written consent from participants and their guardians. exclusion criteria: * previously diagnosed with heart failure, severe malnutrition, immune deficiency, liver or kidney disease, cancer, or other diseases deemed unsuitable for participation. * taking weight loss drugs, or undergone weight loss surgery. * attending behavior-based intervention programs (exercise or diet) within a year. * regular hiit (at least once per week). * secondary obesity, such as neuropsychiatric disorders, endocrine disorders, sleep apnea syndrome, or other conditions. * unable to take interventions due to health conditions, such as joint diseases, fractures, injuries. * other situations unsuitable for participation.

Keywords: cardiovascular diseases metabolic disorders high-intensity interval training school-aged children childhood obesity
survey of the moderna covid-19 vaccine in people at high-risk of developing severe covid-19 symptoms

Conditions: Coronavirus Disease (COVID-19)

Summary: this study is a survey of the moderna covid-19 vaccine in japanese people at high risk of developing severe covid-19 symptoms. the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. the main aim of the study is to check for side effects of the moderna covid-19 vaccine in this group. this will be from the first vaccination to 28 days after the second vaccination. the number of visits to the clinic will depend on the clinic's standard practice.


Eligibility criteria:
inclusion criteria: 1. the participant is capable of understanding the contents of the investigation, recording his/her own symptoms in the health observation diary, and has obtained written consent to participate in the investigation from the vaccinee himself/herself (if minor, parent or legal guardian). 2. the participant has an underlying disease at the time of this drug vaccination that is considered to pose a high risk of aggravation of covid-19. exclusion criteria: 1. the subject has any contraindication to this drug.
a proof of concept study for the dna repair driven by the mesenchymal stem cells in critical covid-19 patients

Conditions: COVID-19 Pneumonia

Summary: our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on dna repair genes. patients diagnosed with covid-19 infection are divided into two equal (n:30) groups. group-1(n/15): patients in critically ill condition receiving conventional therapy, group-2 (n/15): patients in critically ill condition receiving conventional therapy and systemically transplanted mscs. the dna repair pathway will be examined as 11 genes in 5 different parts. investigated parameters: 1. base excision repair 2. nucleotide excision repair 3. recombinational repair 4. mismatch repair 5. direct reversal investigated parameters: broad biochemical analysis, apoptosis, clinical outcome, and mortality rates.

our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on dna repair genes. patients diagnosed with covid-19 infection are divided into two equal (n:30) groups. group-1(n/15): patients in critically ill condition receiving conventional therapy, group-2 (n/15): patients in critically ill condition receiving conventional therapy and systemically transplanted mscs. the dna repair pathway will be examined as 11 genes in 5 different parts. investigated parameters: 1. base excision repair 2. nucleotide excision repair 3. recombinational repair 4. mismatch repair 5. direct reversal investigated parameters: broad biochemical analysis, apoptosis, clinical outcome, and mortality rates.

Eligibility criteria:
inclusion criteria: 1. 40-65 years old male/female. 2. obtaining informed consent from him or his legal relative. 3. confirmed covid-19 related severe ards cases. exclusion criteria: pregnant, malignant tumours, the ones who has confirmed co-infection; history of using long-term immunosuppressive agents

Keywords: covid-19 critical case dna repair dan damage