Kornimate/medical-research-clean huggingface dataset:
an individual-specific synchrony signature

Conditions: Major Depressive Disorder

Summary: this study aims to establish synchrony as an individual-specific mechanism of therapeutic change and offers novel insights into the mechanisms of curative interpersonal processes. the study identifies individual-specific trait-like synchrony signature and investigates the associations between synchrony signature, the individual's trait-like characteristics, and mental health, among participants diagnosed with major depressive disorder. the study further investigates how deterministic the trait-like synchrony signature is by identifying for whom, how, and when changes are anticipated. additionally, it examines whether synchrony signature transfers to relationships with the therapist, whether and how it changes throughout treatment, and whether such potential changes are associated with improvements in mental health. synchrony is recognized as a key driver of collaborative, affiliative, and curative relationships. while its potential role in improving mental health through interpersonal relationships has sparked growing interest, particularly in psychotherapy, the field is at a crossroads, with mixed findings challenging the widespread theoretical assumption that "more synchrony is better." this study introduces a personalized framework that emphasizes individual-specific synchrony signatures, shifting from generalized assumptions to tailored understanding and interventions. the study explores how synchrony can transform relationships into curative ones by leveraging individual-tailored changes in synchrony signatures in psychotherapy. the potential impact is vast. tailoring synchrony to individual-specific signatures represents a paradigm shift from a one-size-fits-all approach to personalized interventions. this personalized framework could revolutionize mental health care by facilitating the development of targeted strategies that enhance treatment outcomes.


Eligibility criteria:
inclusion criteria: * current major depressive disorder based on the diagnostic and statistical manual of mental disorders-5, and scores above 14 on the 17-item hamilton rating scale for depression at two consecutive assessments, one week apart. * for participants using psychiatric medication, the dosage must be stable for at least three months before the beginning of the study, and they will be asked to maintain stable dosage during the treatment * age between 18 and 65 years * hebrew language proficiency * provision of written informed consent. exclusion criteria: * current risk of suicide or self-harm * current substance abuse disorders * current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring * history of organic mental disease * currently in psychotherapy

Keywords: synchrony therapeutic relationship trait-like state-like multi-modal mechanisms of change
a randomized controlled clinical trial: hydroxychloroquine for the treatment of covid-19 in hospitalized patients

Conditions: COVID-19

Summary: this study is a randomized, open label clinical trial to evaluate the safety and efficacy of hydroxychloroquine (hcq) plus usual care compared to usual care in approximately 350 hospitalized patients diagnosed with covid-19. the study will be a 2-arm, non-blinded comparison between open label hydroxychloroquine and usual care. the course of treatment (hcq) is five days. participants will be followed to study day 28.

the overall objective is to evaluate the clinical efficacy and safety of hydroxychloroquine (hcq) relative to standard of care among 350 hospitalized adult patients who have covid-19. primary aim i. clinical status (on a 7-point ordinal scale) at day 15 clinical status 7-point ordinal scale: 1. not hospitalized, no limitations on activities 2. not hospitalized, limitation on activities 3. hospitalized, not requiring supplemental oxygen 4. hospitalized, requiring supplemental oxygen 5. hospitalized, on non-invasive ventilation or high flow oxygen devices 6. hospitalized, on invasive mechanical ventilation or ecmo 7. death after enrollment and randomization there will be baseline and then daily assessments of clinical status and test results and procedures during hospitalization. course of hcq treatment is 5 days. participants are followed daily during hospitalization. all procedures, evaluations and treatment, including the hydroxychloroquine laboratory tests, and radiology tests are part of the usual clinical care for covid-19 patients. this study will only collect the information obtained as part of hospital standard of care. if the information is not available, it will not be obtained by any other mechanism. after discharge there is a follow up telephone call at day 15 and day 28. follow-up assessment includes any clinical events, adverse events, and clinic or emergency visits or hospitalizations. participants in the hcq arm have safety labs: cbc and comprehensive metabolic profile scheduled on day 7 and 14.

Eligibility criteria:
inclusion criteria: i. subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. ii. understands and agrees to comply with planned study procedures. iii. male or female adult ≥18 - 95 years of age at time of enrolment. iv. laboratory-confirmed sars-cov-2 infection in any specimen \< 5 days prior to randomization. v. at least one of the following: 1. radiographic infiltrates by imaging (chest x-ray, ct scan, etc.) or 2. clinical assessment (evidence of rales/crackles on exam) and spo2 ≤94% on room air vi. women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study. exclusion criteria: i. history of liver failure ii. history of stage 4 severe chronic kidney disease or requiring dialysis iii. self-reported pregnant or breast feeding. iv. allergy to hydroxychloroquine or choloroquine v. known contraindication to hydroxychloroquine, including retinopathy, g6pd deficiency, qt prolongation
improving sleep in rehabilitation after stroke

Conditions: Stroke

Summary: this study evaluates the efficacy of digital cognitive behavioural therapy for insomnia (sleepio) in chronic stroke survivors. half of the participants will receive access to the digital (online) programme, half will receive a leaflet with sleep hygiene information. the primary outcome will be changes in sleep quality, assessed as the score on the sleep condition indicator.

stroke is one of the leading causes of adult disability. many stroke survivors report difficulties with sleep and our current research confirms this, indicating that chronic community dwelling stroke survivors experience poorer self-reported and objective sleep quality than age matched healthy controls. "sleepio" is an online cognitive behavioural therapy for insomnia (cbt-i) programme. the efficacy of this intervention has been demonstrated in people with chronic insomnia but has not yet been tested in people with stroke. the study therefore aims to determine whether digital cbt-i is effective for improving sleep quality in chronic stroke survivors. participants will be randomised to receive either digital (online) cbt-i or a leaflet with sleep hygiene information. the primary outcome is the change in self-reported sleep quality, assessed using the sleep condition indicator. secondary outcomes include changes in sleep fragmentation and wake after sleep onset assessed with actigraphy, self-reported sleep onset latency from the sleep diaries, anxiety and depression using the phq9 and gad7, quality of life using the sis-8 and eq-5d-5l as well as changes in healthcare costs during the 8 week follow up.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * at least 18 years of age * at least 3 months post stroke * interest in improving sleep * can understand verbal and written english well enough to engage with the programme and study procedures (with assistance from carer if needed). * reliable access to internet * currently living in the united kingdom * current stable health exclusion criteria: * serious physical health concerns with surgery scheduled in the next 5 months * undergoing a psychological treatment programme for insomnia (with a health professional or online) * pregnancy * uncontrolled seizures * untreated diagnosed obstructive sleep apnoea * habitual night shift, evening or rotating shift-workers * other serious clinical condition that may affect participation in the study

Keywords: sleep rehabilitation digital cognitive behavioural therapy for insomnia
effect of whole body vibration therapy on pain, muscle strength, balance and quality of life in knee osteoarthritis

Conditions: Osteoarthritis, Knee; Osteoarthritis

Summary: the aim of this study is to examine the effects of whole body vibration therapy on knee osteoarthritis. while the participants did static exercise in one group, whole body vibration therapy was applied during static exercise in another group. as a result of 15 sessions of treatment in both groups, the effects on pain, muscle strength, balance and quality of life were compared.


Eligibility criteria:
inclusion criteria: * those who were diagnosed with primary symptomatic knee oa according to acr criteria,ages between 35 and 70, body mass index (bmi) ⩽35, grade ii or iii according to kellgren \& lawrence scale, patients with persistent symptoms such as pain and stiffness for at least 3 months were included. exclusion criteria: * those who have had knee surgery before, those with central nervous system disease (especially epilepsy and serious psychotic disorders), those with a history of acute arthritis, those with a history of dvt in the last 24 weeks, those with advanced lung or heart disease (copd and heart failure), those diagnosed with inflammatory rheumatic diseases (rheumatoid arthritis, spondyloarthropathy, etc.), patients diagnosed with advanced stage cancer were excluded from the study.

Keywords: vibration whole body vibration osteoarthritis osteoarthritis, knee
comparison of the clinical effects of two tear substitutes in patients with dry eye syndrome

Conditions: Dry Eye

Summary: with the potential to address evaporative dry eye, liposic and tears naturale forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. this study compare the effects of liposic and tears naturale forte application on the lipid and stability of the tear film in dry eye patients.


Eligibility criteria:
inclusion criteria: * minimum age of 20 years(range from 20 year to 25 years) * the value of osdi is over 12 * nbut is less 5 seconds * schirmer 1 test is less 10mm * the basical lipid layer grade is 1-2 exclusion criteria: * any corneal,conjunctival, or eyelid abnormalities; conjunctivitis; current ocular infection; photophobia that may cause reflex tearing or difficulty in evaluating the patient's lipid layer; * known allergic sensitivity to any of the ingredients in liposic or tears naturale forte

Keywords: tear film lipid layer liposic tears naturale forte
validation of a smart phone app to non-invasively measure the size of children

Conditions: Growth and Development

Summary: smart phones are omnipresent. apps exist to calculate size of medical equipment and doses of medication if a valid weight or age is entered. during emergency situations, these values are often unknown. an app has been developed to measure the size of a child noninvasively. this app is now to be validated in clinical practice. app measured size is calculated and compared to the real size of a child. via known percentiles of age/weight of the child is calculated upon the app measured size. this value is compared to the mother's, physician's and nurses estimation of the size and weight. depending on the size multiple algorithms exist to estimate weight, age and medical values. ("kindersicher ®", "notfalllineal ®" and "broselow tape ®"). these estimations by the calculations will also be compared to actual weight and age. children from 0-12 years of age are included in the emergency department of the children's hospital of the university of zurich after informed consent obtained by the parents. no therapy decisions from these calculations will be made. the therapy is independent of this study.


Eligibility criteria:
inclusion criteria: * male and female patients 0-12 years of age (45 per age group) * obtained informed consent * admitted to the emergency department of the children's hospital of the university of zurich exclusion criteria: * physically or mentally unable for measurement * denial of informed consent

Keywords: emergency department estimation of age and weight size measurement
a pilot study to determine fructose uptake by primary human colorectal tumors

Conditions: Colorectal Tumors

Summary: this proposed study is designed to investigate the specific uptake of fructose by human colorectal tumors. in this study, subjects with colorectal cancer undergoing surgery will receive an oral sugar solution containing fructose or xylose prior to surgery. the tumor will then be resected, and a portion of the tissue will be used to measure the abundance of fructose and xylose. the study hypothesis is that the tumors will take up fructose sugar but not xylose sugar. a comparison of the sugar uptake between the tumor and normal tissues from the adjacent intestinal epithelium and smooth muscle and the liver will be conducted. this proposal will confirm that human colorectal cancer tumors can directly absorb dietary sugars, which has never been demonstrated.

this prospective pilot study is designed to investigate the uptake of dietary fructose and xylose by primary human colon tumors. in this study, the recruited patients with colorectal cancer will receive an oral sugar solution containing either fructose sugar or xylose sugar before surgery. the tumor will then be resected and a portion of the tumor, normal intestinal tissue, blood, urine, and liver will be used to quantify fructose and xylose. * research question can primary human tumors take up fructose or xylose? * a statement of the hypothesis the hypothesis is that fructose, but not xylose, can be directly absorbed and stored by primary human colon tumors. * design prospective, non-randomized, pilot, feasibility, single-center, open-label, phase 1, investigator-initiated study to evaluate the uptake of dietary fructose and xylose by primary human colon tumors with 12 subjects in 2 cohorts: cohort 1: 6 subjects will consume a sugar solution containing fructose and cohort 2: 6 subjects will consume a sugar solution containing xylose. eligible subjects that are scheduled to undergo colorectal resection for cancer treatment will be invited to participate in the study in consecutive order from the practice of colorectal surgeons at the time of their preoperative clinic visit. first, cohort 1 subjects will be enrolled followed by the cohort 2 subjects. n=12 subjects cohort 1: fructose sugar solution =6 subjects cohort 2: xylose sugar solution=6 subjects

Eligibility criteria:
inclusion criteria: * subjects of 18 years of age or older, male, and female * subjects with a diagnosis of invasive non-hereditary colonic adenocarcinoma who will be undergoing standard of care (soc) laparoscopic, robot-assisted, or open surgical resection * the subject provides informed consent exclusion criteria: * subjects with a history of uncontrolled diabetes mellitus (a1c \>7.0) type i and type 2, will be excluded to avoid potential confounders associated with the consumption of a large bolus of sugar (e.g., hyperglycemia and hyperinsulinemia) * inflammatory bowel disease (ulcerative colitis or crohn's disease) * patients on steroid medications * patients with current infectious disease * subjects who do not speak english

Keywords: fructose d-xylose primary human colorectal tumors
is acupoints sensation necessary for acu-tens to elicit physiological changes in healthy subjects?

Conditions: Autonomic Nervous System Disorder

Summary: traditional chinese medicine (tcm) practitioners believe that health can be maintained if the body has a balanced ying-yang or the qi flows in correct strength and quality along the meridians.stimulation of the acupoints such as by acupuncture can awaken and modulate qi in the channels and is able to regulate and restore yin-yang balance.however, there are some drawbacks associated with acupuncture which may limit its applications. these include transmission of infectious disease, pneumothorax and other problems associated with organ punctures, cardiac tamponade, and broken needles with remnants migrating to other locations.studies have shown that when tens is applied over acupoints (acu-tens), it is effective in reducing dyspnoea in patients with chronic obstructive pulmonary disease,facilitate early haemodynamic recovery after open-heart surgery,relieve labor pain,increase in blood β-endorphin level,reduce blood pressure changes in normal healthy subjects and decrease airway resistance.despite these promising results, how acu-tens works still remain unclear.this study aimed to investigate the effects of acu-tens over hegu (li4) and quichi (li4) on the autonomic nervous system activities and to investigate whether the subject could experience distinct sensation as deqi.

eligibility criteria: normal healthy subjects who were naïve to acu-tens and able to read chinese. outcome measures: heart rate, mean arterial blood pressure, heart rate variability

Eligibility criteria:
inclusion criteria: * normal healthy subjects who were naïve to acu-tens and able to read chinese were recruited for study exclusion criteria: * history of cardiopulmonary, neurological and psychologic disorders or they required taking drugs within one week that might affect the cardiovascular and neurological status

Keywords: acu-tens map hr hrv
nts-wbrt in brain metastases

Conditions: Brain Metastases

Summary: this research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (nts-wbrt). this research study involves: * nts-wbrt (normal tissue sparing whole brain radiation therapy) * memantine standard of care drug

this is a phase 2 trial testing the safety and effectiveness of nts-wbrt (normal tissue sparing whole brain radiation therapy) in treating brain metastases. nts-wbrt is a targeted radiation therapy that further reduces radiation dose to tissue that does not need radiation therapy treatment. the research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. it is expected that about 41 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * any patient with a solid tumor diagnosis and any number of brain metastasis clinically indicated for cranial irradiation with whole brain radiation therapy * age ≥ 18 * karnofsky performance status ≥ 70 * prior stereotactic radiosurgery (srs) permissible per physician discretion * prior craniotomy permissible per physician discretion. protocol radiation therapy should be initiated ≥2 weeks after craniotomy. * prior partial brain radiation therapy permissible if target volume \< 50% brain and per physician discretion * expectant \> 6 months survival * ability to understand and the willingness to sign a written informed consent document. * fluency in english, able to complete questionnaires and neurocognitive testing * ability to undergo mri with gadolinium examination * ability to return for follow-up examinations throughout the course of this study for a maximum of 2 years after radiation treatment completion * any prior, concomitant, or post-radiotherapy systemic therapy is permitted at discretion of treating physicians * negative pregnancy test for premenopausal women exclusion criteria: * leptomeningeal disease (by any one or more of clinical assessment, radiographic assessment, or cerebrospinal fluid study) * prior whole brain radiation therapy * pre-existing or current use of memantine or other nmda antagonists * known allergy to contrast used in imaging studies and/or inability to have mri imaging * uncontrolled intercurrent illness that could significantly affect baseline cognitive function as determined by the enrolling clinician, such as symptomatic congestive heart failure, unstable angina pectoris, prior cva, significant uncontrolled epilepsy or psychiatric illness/social situations that would limit compliance with study requirements * pregnant or unwilling to use appropriate contraception to prevent pregnancy during the time of radiation therapy * concurrent participation in an investigational systemic therapy protocol.

Keywords: brain metastases
self-expandable, fully covered metal stents in biliary strictures due to chronic pancreatitis

Conditions: Benign Biliary Strictures; Chronic Pancreatitis

Summary: the purpose of the study was to analyze the resolution rate of benign biliary strictures due to chronic pancreatitis after temporary insertion of unflared-ends and flared-ends fully covered self-expandable metal stents.

endoscopic treatment of benign biliary strictures include the placement of plastic stents or self-expandable metal stents. long term results of placement of a single plastic stent are disappointing. better results have been obtained by endoscopic insertion of multiple plastic stents. biliary self-expandable metal stents used for malignant strictures are uncovered or partially covered with a plastic coating. more recently, fully covered sems have been developed and are now available on the market and due to their removability are proposed also for benign indications. uncovered and partially covered biliary self-expandable metal stents for chronic pancreatitis-related benign biliary strictures on long-term may clog due to tissue ingrowth through the uncovered meshes. removable fully covered self-expandable metal stents seem to be an attractive option for cp-related bbs, but scarce data are available in the literature. the investigators conducted a feasibility, prospective, tertiary single-centre trial to investigate the durable resolution of chronic pancreatitis-related benign biliary strictures after temporary insertion of fc sems with unflared-ends and flared-ends.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years, 2. symptomatic (persistent cholestasis, jaundice, cholangitis) common bile duct strictures secondary to cp, that persist 3 months or more after placement of a single 10 french plastic stent and 3. patient unfit for surgery (portal cavernomatosis, comorbidities) or patient refusal of surgery. exclusion criteria: 1. benign biliary strictures secondary to compression from a pancreatic pseudocyst; 2. patients with associated pancreatic neoplasia 3. ongoing alcohol abuse (ethanol \> 80 g/day).

Keywords: benign biliary strictures chronic pancreatitis