Kornimate/medical-research-clean huggingface dataset:
trial to evaluate the efficacy and safety of hcp1302

Conditions: Erectile Dysfunction; Hypertension

Summary: trial to evaluate the efficacy and safety of hcp1302

a randomized, double-blind, multicenter, phase ⅲ study to evaluate the efficacy and safety of hcp1302 in both erectile dysfunction and hypertension patients being treated with hgp0904

Eligibility criteria:
at visit1 1. ≥19 age 2. hypertension patients who need amlodipine 5mg 3. abnormal erectile function ≥ at least 3months based on screening date 4. patients who are expected to frequent use of tadalafil (at least two times for weeks) 5. patients understood the consents and purpose of this trial and signed informed consent form at visit2 1. 90≤ sitsbp \< 140 mmhg and 50 ≤ sitdbp \< 90 mmhg 2. sexual dysfunction rate ≥ 50% for 4 weeks run-in period 3. international index of erectile function(iief)- erectile function(ef) domain score ≤ 25 exclusion criteria: 1. history of hypersensitivity to amlodipine or tadalafil 2. has a severe liver disorder(child-pugh class c) or liver enzyme (ast, alt) level exceeds 3 times more than normal upper range 3. has a clinically significant renal failure (scr \> 2mg/dl) 4. uncontrolled diabetes mellitus (hba1c \>12%) 5. at screening date, blood pressure gap of selected arms is sitsbp ≥20mmhg or sitdbp ≥10mmhg 6. taking pde-5 inhibitors or other therapeutic agents for erectile dysfunction within 7 days based on screening date 7. no reaction to pde-5 inhibitors

Keywords: erectile dysfunction & hypertension
non-invasive vagal neurostimulation (nvns) in adolescents with postural orthostatic tachycardia syndrome (pots)

Conditions: Postural Tachycardia Syndrome; Autonomic Dysfunction; Postural Orthostatic Tachycardia Syndrome; POTS - Postural Orthostatic Tachycardia Syndrome

Summary: the purpose of this study is to determine if nvns will decrease autonomic symptom intensity (compass-31 and child functional disability inventory) in adolescent patients with postural orthostatic tachycardia syndrome (pots) in comparison to standard recovery steps management.

project purpose: the investigators will study the use of non invasive vagal nerve stimulation in newly diagnosed adolescent patients with pots to see if symptom management improves over 2 months. surveys will include compass-31. child functional disability inventory, and phq-9. patient logs will evaluate headache frequency, exercise duration and vns use. research objectives: the investigators hypothesize that: primary aim 1. use of noninvasive vagal nerve stimulation will decrease autonomic symptom intensity compared to control group. primary aim 2. use of noninvasive vagal nerve stimulator will improve child function. primary aim 3. heart rate elevation measured by head up tilt table test will decrease in the treatment group compared to the control group. secondary goals include: secondary aim 1: to determine if utilization of noninvasive vagal nerve stimulation influences headache frequency secondary aim 2: determine if utilization of noninvasive vagal nerve stimulation will influence weekly duration of aerobic exercise. secondary aim 3: determine if utilization of noninvasive vagal nerve stimulator results in significant side effects, particularly depression, in adolescent patients.

Eligibility criteria:
inclusion criteria: 1. patient's age 12-19 years of age 2. newly diagnosed pots at mayo clinic in rochester 3. head up tilt table test results in a heart rate increase of 40 or more bpm 4. consent is able to be obtained appropriately per age exclusion criteria: 1. pots patients with orthostatic hypotension 2. pots patients with vasovagal syncope 3. use of medications other than midodrine or metoprolol 4. inability to independently utilize the gammacore device 5. inability to independently complete surveys or patient logs 6. patients receiving hormonal therapy other than birth control 7. pregnancy 8. prior neck surgery 9. metallic implant present 10. cardiac disorder 11. presence of an eating disorder 12. use of a feeding tube
hfno reduces hypoxia during sedated gastroscopy or colonoscopy in high risk patients

Conditions: Gastric Cancer; Intestinal Cancer; Intestine Adenoma; Gastritis

Summary: the objective of this study is to observe the preventive effects of high flow nasal oxygenation on the incidence of hypoxia during gastroscopy or colonoscopy sedated with propofol in high-risk patients.


Eligibility criteria:
inclusion criteria: 1. age ranging from 18 to 80, both sexes 2. patients receiving selective gastroscopy or colonoscopy or gastroscopy and colonoscopy procedure 3. asa ⅲ\~ⅳ 4. 18 kg/m2\<bmi\<28kg/m2 5. the anticipated operation time of the procedure shall be less than 30min. 6. patients should clearly understand and voluntarily participate in the study, with signed informed consent. exclusion criteria: 1. patients with nasal congestion, epistaxis, recent nasal trauma, recent nasal surgery, increased intracranial pressure and skull fracture, etc. who can not tolerate high-flow nasal cannula. 2. patients diagnosed pocd 3. patients clearly identified difficult airway 4. patients with mechanical ventilation 5. patients with acute respiratory infection and asthma 6. patients with acute upper gastrointestinal hemorrhage accompanied by shock, severe anemia, gastrointestinal obstruction accompanied by retention of gastric contents 7. patients with aortic stenosis and carotid stenosis 8. patients allergic to sedatives such as propofol 9. patients without civil capacity such as cognitive dysfunction

Keywords: gastroscopy high-flow nasal oxygenation hypoxia high-risk colonoscopy
evaluation of the naturalistic user experience of the website "ich bin alles @schule" (i am everything @school)

Conditions: Depression; Depressive Disorder; Depression in Children; Depression in Adolescence

Summary: the aim of this study is to investigate the naturalistic user experience and acceptance of the german website "ich bin alles @schule". this website for educational professionals offers information on depression and mental health of pupils. another aim of this study is to determine whether the desired target groups of the website can be reached.

depressive disorders are among the most common psychiatric disorders in childhood and adolescence and yet often are unnoticed and not treated for a long time. depressive disorders often begin in adolescence and young adulthood. school stress, caused by bullying experiences at school or high performance expectations from parents and teachers, has been identified as an important factor in the development of depressive disorders in students. school, as a central area of life for children and young people, is an important place for promoting pupils' mental health. the rising prevalence of depressive disorders among adolescence in recent years and the delayed start of interventions show a clear need for action in the everyday lives of adolescents. the department of child and adolescent psychiatry of the hospital of the lmu munich and the beisheim foundation launched the innovative digital information portal "ich bin alles @schule" (i am everything @school; www.schule.ich-bin-alles.de) in november 2023. "ich bin alles @schule" is a german information platform that was developed for educational professionals and aims to provide low-threshold information about depression and mental health in the school context. due to the high relevance of comprehensively evaluating web-based information services on mental health and mental illness, the aim of this study is to use established methods to learn more about the visitors of "ich bin alles @schule" and their user experience. the aim of the study is a scientific evaluation of the naturalistic user experience of "ich bin alles @schule" users. for this purpose, an online questionnaire and the website analysis tool "matomo" is applied. the study is intended to provide clues as to whether the "ich bin alles @schule" information platform is a useful and trustworthy source of information for the target group. the information obtained is of central importance for potential adaptations and optimizations of the website. another aim of this study is to determine whether we can actually reach the desired target group with our website. the results of the data collection also provide an important basis for future approaches aimed at school professionals about mental health issues and mental illness in a way that is appropriate for the target group.

Eligibility criteria:
inclusion criteria: * 40 seconds website-use exclusion criteria: -

Keywords: depression prevention web-based adolescents mental health school user experience acceptance teachers
is the npwti better than the conventional npwt

Conditions: Postoperative Wound Infection Superficial Incisional; Postoperative Wound Infection Deep Incisional Surgical Site

Summary: the goal of this clinical trial is to compare the effectiveness of npwti and npwt in superficial and deep surgical site infections using an improvised system with continuous lavage with saline and chlorhexidine. the main question it aims to answer is whether the npwti is better than conventional npwt. participants will be given npwti or conventional npwt. researchers will compare the two groups to see if npwti diminishes the rate of recurrent infections and the number of reoperations, shortens the hospital stay, and alleviates the burden on the hospital staff in comparison to the conventional npwt.


Eligibility criteria:
inclusion criteria: * adults over 18 years * superficial or deep ssis after laparotomy or laparoscopic surgery exclusion criteria: * persons \< 18 years * documented inherited or acquired coagulation disorders or platelet deficiency * presence of deep space infection (intra-abdominal abscess or ongoing peritonitis) * prosthetic material infection

Keywords: npwti conventional npwt superficial and deep ssis
exploratory study on dosage of qizhi weitong granules in the treatment of irritable bowel syndrome （ibs)

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study are as follows: 1) to evaluate the efficacy and safety of qizhi weitong granules in the treatment of diarrhea-type irritable bowel syndrome (ibs-d);2) to explore the dosage of qizhi weitong granulesin treatment of ibs-d.


Eligibility criteria:
inclusion criteria: * in line with the diagnostic criteria of western medicine ibs-d; * aged 18-65 (including 18 and 65 years old) years; * the mean weekly nrs score for abdominal pain (the most severe in the past 24 hours) was between 3.0 and 7.0 within the last week, and there were at least 2 days per week when fecal traits were classified as type 6 or 7; * informed consent, voluntary test. exclusion criteria: * stool number of type 7 according to bristol stool chart, more than 3 times per day; * tcm syndrome was diagnosed as deficiency of spleen and kidney yang syndrome； * patients who took emergency medication (piveronium bromide tablets) more than the standard during admission period (more than 2 days per week on average)； * patients who have been diagnosed with organic diseases of digestive system, such as inflammatory bowel disease, intestinal tuberculosis, intestinal tumor, etc., or are still complicated with peptic ulcer and infectious diarrhea； * patients with similar symptoms of ibs, such as eosinophilic enteritis, collagenous enteritis, lactose intolerance, etc. * patients with intestinal diseases of digestive system, such as tuberculous peritonitis, cirrhosis, chronic pancreatitis, etc. * patients with systemic diseases affecting digestive tract function, such as hyperthyroidism or hypothyroidism, endometriosis, chronic renal insufficiency, autoimmune diseases, diabetes, etc. * previous gastrointestinal surgery (except for appendicitis); * patients with serious cardiovascular diseases, serious liver and kidney diseases, hematopoietic system diseases, tumor, neurological or psychiatric system diseases; * major anxiety (sas score ≥70) or major depression (sds score ≥73); * concomitant drugs affecting gastrointestinal motility and function (prokinetic drugs, anticholinergic drugs, calcium channel blockers, 5-ht3 receptor antagonists, antidiarrhea agents, antacids, antidepressants, antianxiety drugs, intestinal microbiota regulators, antibiotics, etc.) should not be discontinued in the test; * pregnant or lactating women who had a birth plan from enrollment to 3 months after the end of the trial. * allergic to the test drug emergency drug and its ingredients; * suspected or confirmed history of alcohol or drug abuse; * patients who participated in other clinical trials within 1 month prior to enrollment; * other subjects considered unsuitable for clinical trials by the researchers.

Keywords: qizhi weitong granules irritable bowel syndrome
rectal indomethacin to prevent acute pancreatitis in eus-fna of pancreatic cysts

Conditions: Pancreatic Cyst; Pancreatitis, Acute

Summary: the aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing eus-fna of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during eus-fna.

pancreatic cysts are pre-malignant lesions and are being increasingly diagnosed on cross-sectional imaging. endoscopic ultrasound (eus) is performed to further evaluate pancreatic cysts, and fine needle aspiration (fna) is conducted to obtain a sample of the cystic fluid for analysis and examination for malignant cells. acute pancreatitis is a complication of endoscopic ultrasound-guided fine needle aspiration (eus-fna) of pancreatic cysts, which can lead to significant morbidity and substantial health care costs. the aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing eus-fna of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during eus-fna.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * suspected or confirmed pancreatic cyst seen on imaging, requiring eus-fna exclusion criteria: * unable to obtain consent from the participant or the participant's legally authorized representative (lar) * intrauterine pregnancy * hypersensitivity reaction to aspirin or nsaids * patients with known history of chronic pancreatitis * patients with known renal failure
trigger point dry needling vs trigger point dry needling with intramuscular electrical stimulation

Conditions: Sub-acute and Chronic Low Back Pain

Summary: trigger point dry needling with intramuscular electrical stimulation vs trigger point dry needling

the purpose of this study is to evaluate if trigger point dry needling with intramuscular electrical stimulation is more effective in decreasing pain and disability in individuals with sub-acute and chronic low back pain (lbp) than with trigger point dry needling alone. the investigators are using a within subjects randomized crossover study that will recruit 30 active duty military personnel or beneficiaries from william beaumont army medical center and all associated clinics. the investigators hypothesize that individuals with lbp will exhibit larger improvements in pain and disability when receiving trigger point dry needling with intramuscular electrical stimulation than when receiving trigger point dry needling alone.

Eligibility criteria:
inclusion criteria: * currently experience low back pain for greater than 4 weeks (low back pain defined as pain below the t12th vertebrae with or without radiation) military or dod beneficiary (any branch; 18-65 years of age) exclusion criteria: * structural deformity (ankylosing spondylitis, scoliosis) * has any other orthopedic condition that may keep subject from performing low - back exercises * tumors * spinal infection or local infection * pregnancy-all female subjects will be given either a blood serum or urine pregnancy test. * spinal cord compression or cauda equina syndrome * subject with the inability to keep appointments * has history of prior surgery * has received dry needling or acupuncture in the last 6 months * history of bleeding disorders * high anti-coagulant use * history of immune suppression

Keywords: dry needling electrical stimulation e-stim lbp low back pain trigger point chronic subacute
a study to assess efficacy and safety of bezafibrate in patients with primary biliary cholangitis

Conditions: Primary Biliary Cirrhosis

Summary: up to 40% of patients with pbc have an inadequate response to standard treatment with ursodeoxycholic acid (udca), those patients represent the group in need for additional therapies, having increased risk of disease progression and decreased survival free of liver transplantation. the main objective of the study is to evaluate safety and efficacy of bezafibrate plus ursodesoxicolic acid in patients with pbc and inadequate response to udca.


Eligibility criteria:
inclusion criteria: * pbc diagnosis (consistent with american association for the study of liver disease \[aasld\]: * history of elevated alkaline phosphatase levels. * anti-mitochondrial antibodies positivity * histopathologic evidence of nonsuppurative cholangitis and destruction of small or medium- sized bile ducts. * use of ursodeoxycholic acid (udca) for at least 12 months at enrollment at a therapeutic dose (13 to 15 mg per kg per day). * evidence of a suboptimal biochemical response to udca, defined by the presence of one of the paris ii criteria. * written informed consent. * age ≥ 18 years. exclusion criteria: * hepatic decompensation (ascitis, variceal upper gastrointestinal bleeding, hepatic encephalopathy). * coexistence autoimmune hepatitis. * bilirrubin \>3mg/dl. * for females, pregnancy or breast-feeding. * hepatocellular carcinoma. * history or presence of spontaneous bacterial peritonitis.

Keywords: ursodeoxycholic acid bezafibrate
repair of subscapularis tear :clinical results and mri analysis

Conditions: Rupture Subscapularis Tendon

Summary: this study is to evaluate the magnetic resonance imaging (mri) and clinical results of arthroscopic repair of subscapularis tears

rom ucla constant ases vas mri goutallier

Eligibility criteria:
inclusion criteria: - patients suffering from rotator cuff injury scheduled for an arthroscopic procedure. a partial- or full-thickness subscapu-laris tendon tear exclusion criteria: - revision repairs or open repairs.

Keywords: apularis, mri clinical, results
tdcs as an add-on treatment in ssri-resistant ocd

Conditions: Obsessive-Compulsive Disorder

Summary: the purpose of this study is to determine whether tdcs is effective as an add-on treatment in ssri-resistant patients with obsessive and compulsive disorder

total number of scheduled patients to be recruited: 46 we used the effect size of the study of ruffini and colleagues (2009) in which rtms was used to target the left orbito frontal cortex to calculate the number of patients to be recruited. with a risk alpha of 5%, a power of 80%, the number of patients to be included was 46 with an anticipated rate of 10% of lost to follow-up patients. (calculation was made on the http://www.spc.univ-lyon1.fr/mfcalc/nsn/assistant.htm) statistical analysis to address the primary and secondary objectives: chi squared test will be applied for quantitative data.

Eligibility criteria:
inclusion criteria: * patients diagnosed with ocd according to dsm v criteria * ybocs score of 16 and above, stable (\<20% of variation) during at least one month. * have received for at least 12 weeks of which 6 weeks was either at the maximum tolerated dose or alternatively the manufacturer's recommended maxi- mum daily dose. * age between 18 and 70 * voluntary and competent to consent exclusion criteria: * major depressive disorder diagnosed with the dsm v criteria with a madrs score \>30 (actual) * schizophrenia and other psychotic disorder * drugs or alcohol abuse * acutely suicidal * significant head injury, or of any neurosurgical procedure with implanted material * pregnant women

Keywords: ocd
effect of different ultrasound doses on median nerve conduction parameters

Conditions: Entrapment Neuropathies

Summary: the current study investigates the effect of different doses of pulses ultrasound therapy on different nerve conduction parameters of the median nerve in healthy volunteering subjects.

in the current study, we apply pulsed ultrasound therapy on median nerves of healthy volunteer subjects, at 1 w/cm2 10% duty cycle, 3 w/cm2 10% duty cycle, 1 w/cm2 50% duty cycle, and 3 w/cm2 50% duty cycle. parameters of median nerve conduction study, latency, amplitude, area, duration and forearm ncv are recorded before and after application of ultrasound therapy.

Eligibility criteria:
inclusion criteria: 1. 120 hands of 60 subjects of both genders with age range 18: 24 years. 2. subjects assigned will be apparently healthy subjects with no neurological or neuromuscular history affecting the upper limb. exclusion criteria: 1. peripheral polyneuropathy. 2. diabetes mellitus. 3. previous surgeries or median and/or ulnar nerve release. 4. cervical radiculopathy. 5. median or ulnar entrapment neuropathies. 6. previous or current pregnancies.

Keywords: pulsed ultrasound nerve conduction parameters.
a new approach to a personalized patient blood management program (ppbm) in total hip arthroplasty (tha)

Conditions: Postoperative Anemia

Summary: the study evaluates the patient related risk and predictive factors concerning perioperative homologous blood cell transfusion (erythrocyte concentrate ) in tha patients in one endocert max-certified orthopedic hospital in germany. a patient oriented preoperative decision-making algorithm (a personalised patient blood management or ppbm app) will be developed as a new patient-safety blood-sparing strategy. the aim is to increase the patient safety by using the ppbm app and to reach a more efficient management of resources.

retrospective audit of 470 consecutive primary tha in 2013 and 2014

Eligibility criteria:
inclusion criteria: * primary tha on patients with coxarthrosis exclusion criteria: * any kind of old or acute fractures about the basin and hip * combined surgery, like first extracting a femur nail and than undergoing tha * any other kind of combined or simultaneous surgery * any kind of coagulopathy

Keywords: homologous blood transfusion total hip replacement patient blood management