Kornimate/medical-research-clean huggingface dataset:
phone intervention for alcohol (etoh) use in emergency department motor vehicle crash (ed mvc) patients

Conditions: Alcoholic Intoxication; Wounds and Injuries

Summary: the purpose of this study is to determine if a brief counseling intervention, delivered by telephone, is more effective than standard ed care, to reduce future alcohol related injuries and alcohol related negative consequences, among patients treated in the ed for injuries from an mvc and other injury mechanisms.

alcohol related motor vehicle crashes (mvc) continue to be a substantial public health problem. brief interventions for alcohol (bi) for injured ed patients have been demonstrated to be effective, and perhaps more so for mvc patients. telephone interventions have been utilized in varying ways in health care. we compared the delivery of two brief interventions by telephone against an assessment only condition. participants who received the bi and the assessment only condition were contacted 3 and 12 months after recruitment. data about alcohol use, injuries and high risk behaviors, including drinking and driving behaviors were collected at the 3 and 12 month follow-up assessments.

Eligibility criteria:
inclusion criteria: * 18 years or older * emergency department patient * subacute injury * motor vehicle crash or other injury * alcohol use at harmful and hazardous levels exclusion criteria: * younger than 18 years old * does not meet alcohol use criteria * non-english speaker * in police custody * suicidal * psychiatric diagnosis * no locator * injury occurred \> 72 hours prior to ed visit

Keywords: alcohol use brief interventions injuries emergency department patients harmful and hazardous alcohol use among ed injured patients
improving care provided to patients treated in a level 1 trauma center post-suicide attempt

Conditions: Suicidal Ideas

Summary: the aim of the study is to refine, elaborate, and pilot a brief intervention for adult patients following a suicide attempt provided during hospitalization in an acute medical setting. 40 participants will be randomized to receive the brief intervention + care as usual or only care as usual. it is hypothesized that the intervention will be acceptable and feasible to both patients and intervention clinicians.

the aim of the study is to refine, elaborate, and pilot a brief intervention for adult patients following a suicide attempt provided during hospitalization in an acute medical setting, and will be addressed with a sample of cases (n = 40) from harborview. the participants will be randomized into one of two groups: those that receive the intervention and those that do not. all participants will complete a battery of assessments the intervention is based on the theory of teachable moments, wherein timing in proximity to injury and appropriate treatment setting provide a unique opportunity to create patient behavioral change. the brief intervention consists of engaging the patient in conversation regarding suicidal ambivalence (desire to live vs. desire to die), collaborative discovery of primary and secondary drivers of suicidality, and safety planning. a guide to delivering the intervention has been completed and may undergo changes throughout the study. adherence measures will be developed in order to assess the degree to which the clinician accurately provided the brief intervention without including additional therapeutic elements or leaving out elements required in the intervention guide. best methods for integrating the brief intervention into services provided on medical and surgical units will be determined, as well.

Eligibility criteria:
inclusion criteria: * at least 15 years of age * inpatient on medical/surgical unit * admitted following a suicide attempt * sufficient english to benefit from psychotherapy in english * consents to be a research participant exclusion criteria: * lack of sufficient english to participate in psychotherapy in english * prisoner/inmate at time of admission * too cognitively impaired, delirious, or psychotic to respond to psychotherapeutic intervention before end of stay on medical/surgical unit. determination of cognitive impairment, delirium, agitation, and psychosis will be determined through the referral phone call between the pi and the referring care provider, as well as the pi's own clinical assessment of the patient at the outset of the brief intervention.

Keywords: suicide brief intervention youth acute medical setting readiness to change suicidality
role of allopurinol on oxidative stress and mitochondrial alterations in skeletal muscle of diabetic patients

Conditions: Type 2 Diabetes Mellitus

Summary: our recent data in mice have demonstrated a key role of xanthine oxidase in hyperglycemia-induced by reactive oxygen species production, and a preventive role of allopurinol (inhibitor of xanthine oxidase) on the keeping of mitochondria number and structure, in skeletal muscle of diabetic mice. the investigators want to initiate a clinical trial in order to evaluate the efficacy of allopurinol on the improvement of mitochondrial alterations, oxidative capacities and insulin sensitivity, in skeletal muscle of type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: * bmi from 25 to 40 kg/m² * type 2 diabetes known for over one year but less than 10 years, treated with oral anti-diabetic drugs or a glucagon-like peptide-1 (glp1-analog) * well controlled hypertension (untreated or currently treated) with a systolic blood pressure of 95 to 140 mmhg and diastolic blood pressure of 45 to 90 mmhg and heart frequency of 40 to 100 per minute * recent hba1c \< 9 % * uricemia \> 300 µmol/l * for women : menopausal or contraception * renal function as defined by glomerular filtration rate (gfr) ≥ 80 ml/min/1.73 m2 exclusion criteria: * tobacco ( more than 5 cigarettes) * excessive drinking * known pathology * hypersensitivity to allopurinol * treatment by anticoagulants, allopurinol, regular steroids or nonsteroidal anti-inflammatory drug (nsaid), fibrate or insulin

Keywords: type 2 diabetes mellitus, oxidative stress insulin sensitivity insulin resistance mitochondrial dysfunction skeletal muscle xanthine oxidase allopurinol
geriatric assessmen of elderly "unsuited" patients receiving trabectedin in first line treatment for advanced soft tissue sarcomas (sts)

Conditions: Advanced Soft-tissue Sarcoma; Metastatic Soft-tissue Sarcoma

Summary: the aim of the non-interventional study is to prospectively collect and analyze data on the geriatric assessment of patients undergoing systemic 1st line therapy with trabectedin with focus on patients who have been assessed by the treating physician as being unsuited to receive standard chemotherapy with anthracyclines and / or ifosfamide. trabectedin will be used according to the local smpc. modification of the treatment schedule should follow the standard medical practice at the discretion of the treating physician and is not part of this observational plan.


Eligibility criteria:
inclusion criteria: written informed consent * age of ≥ 60 years at study inclusion with a limited number of "unsuited" patients younger than 60 years * histologically proven advanced and/or metastatic sts, intermediate/high grade * presence of measurable disease according to recist 1.1. (optional, according to local clinical practice) * patients indicated for 1st line treatment with trabectedin according to local smpc * ecog performance status 0, 1 or 2 * bone marrow function according to local smpc * hepatic function according to local smpc * ability to understand and follow study-related instructions exclusion criteria: * histologically proven advanced and/or metastatic sts of the following tumor types: * embryonal rhabdomyosarcoma * chondrosarcoma (excluding extraskeletal myxoid chondrosarcoma) * osteosarcoma (excluding extraskeletal osteosarcoma) * ewing tumors/primitive neuroectodermal tumor * gastrointestinal stromal tumors * dermatofibrosarcoma protuberans * use of any investigational agent within 28 days prior to treatment start * exclusion periods from other studies or simultaneous participation in other clinical studies * contraindications according to the local smpc of yondelis® (see appendix a) * subject is in custody by order of an authority or a court of law * previous assignment to the e-trab study (an individual subject may only be included once in the study) * criteria which in the opinion of the investigator preclude participation for scientific reasons, for reasons of compliance, or for reasons of the subject's safety

Keywords: soft tissue sarcomas (sts) trabectedin metastatic sts patients overall survival
does implementing a urinanylsis protocol based on symptoms decrease length of stay in the emergency department?

Conditions: Urinary Tract Infections

Summary: the implementation of nursing urinanlysis protocols based off of symptoms of urinary infections will significantly decrease the length of a patient's stay in the emergency department.


Eligibility criteria:
inclusion criteria: * patients between 16 and 65 years of age complaining of any of the following: dysuria, hematuria, urinary frequency, urinary urgency exclusion criteria: * any person less than 16 or greater than 65 years of age, history of kidney disease or transplant, foley catherization within the last 30 days, on immuno-suppresent and/or receiving chemotherapy

Keywords: urinary tract infections urine urinalysis urine protocols urinalysis protocols nursing protocols emergency department
molecular analysis and treatment options of thymic malignancies

Conditions: Thymic Epithelial Tumor; Thymic Carcinoma; Thymic Cancer

Summary: thymic malignancies are the most common tumors of the anterior mediastinum, though surgery and radiation often effectively treat thymic carcinomas, a minority continue to progress and eventually lead to death. therefore, there is an unmet need for more effective therapies for thymic malignancies. considering the role of molecular alterations has yet to be defined in the treatment of thymoma and thymic malignancies, there is an urgent recognition that molecular alterations in the thymic malignancies are important to predict response and survival for novel targeted therapies. in summary, identification of genetic alterations in thymic malignancies is increasingly essential to perform molecular diagnostics and individualized treatments. this project aims to create a registry of patients with thymic malignancies to further the characterization of molecular alterations and develop (novel) treatments based on the detection.


Eligibility criteria:
inclusion criteria: * histologically proven diagnosis of thymic malignancies * 18 years of age or older * ability to understand and the willingness to sign a written informed consent document

Keywords: thymic malignancy thymoma chemotherapy targeted therapy immunotherapy molecular landscape
sand play vs. cuff training: visual-motor skills in autism

Conditions: Autism Spectrum Disorder

Summary: this study compares image-sand play therapy and tabletop training with weighted cuffs for improving visual-motor integration (vmi) in children with autism. a 12-week randomized controlled trial will be conducted at tanzeem-ul-nisan, faisalabad. beery vmi will assess outcomes. data will be analyzed using spss-23. non-probability conventional sampling will be used. sessions occur twice weekly.

this study compares the effectiveness of image-sand play therapy and tabletop training with weighted cuffs in improving visual-motor integration (vmi) in children with autism. methods: a randomized controlled trial will be conducted with children diagnosed with autism from tanzeem-ul-nisan, faisalabad. participants will be randomly assigned to either intervention group. both therapies will run for 12 weeks, with two sessions per week. image-sand play therapy: creative sand tray play guided by a therapist. tabletop training: structured tasks with weighted cuffs for proprioceptive input. assessment tool: beery vmi sampling: non-probability conventional sampling data analysis: spss version 23, using baseline, mid, and post-intervention scores to compare effectiveness.

Eligibility criteria:
inclusion criteria: * age 5-8 yrs * a diagnosed by autism * guardian of child patients signed the informed consent * both gender male and female exclusion criteria: * complication of serious medical disease * children and parents who cannot comply with the research * surgical procedures performed in the year prior to the study * poor medical conditions preventing participation

Keywords: sand play, table-top training, beery vmi
bedside assessment of immune function in patients with covid-19

Conditions: Covid19

Summary: covid-19 is a global pandemic causing unprecedented morbidity and mortality in the general population. it appears to have a greater effect on the elderly or those with underlying health problems but is not exclusively confined to these groups. as people age, particularly toward the end of their lives, the response of the immune system begins to drop away, an occurrence known as immunosenescence. it is known that there exist a group of people that do not respond to immune stimulation in a normal way but who may to observers be considered fit and healthy. the leukocyte immune test (lit) relies upon the supramaximal stimulation of white cells outside of the body to determine their reactiveness when stimulated. it is intended to study patients admitted to barts health with diagnosed covid-19. 4 ml blood will be taken of which 10microlitres will be used for the lit. the remainder will be used for measurement of antibody levels previously associated with poor outcome following cardiac surgery. the patients will be followed up to see the proportion that progress to requirement for critical care, advanced ventilatory support, renal failure and in-hospital mortality. if a link can be established between a poor outcome following admission to hospital with covid-19 and the immune response on admission, as predicted by means of the lit, then it may enable better formulation of potential treatment strategies. being able to measure at point of admission the responsiveness of someone's immune system may mean that treatment strategies such as the administration of passive immunization either via convalescent plasma or gammaglobulin will be better guided. if the lit proves able to identify those people at risk of severe disease it may be able to identify individuals amongst healthcare workers that may benefit from passive immunisation or avoidance of high-risk exposure to covid-19.


Eligibility criteria:
inclusion criteria: * over 18y age suspected diagnosis of covid-19 able to give written informed consent exclusion criteria: * unwilling or unable to give consent under 18years of age suffering from other acute septic/infective illness other than covid-19

Keywords: immune neutrophil covid 19
urinary incontinence after radical prostatectomy

Conditions: Incontinence, Urinary; Radical Prostatectomy

Summary: the aims of this project are; 1) to examine the efficacy of ultrasound-guided pelvic floor muscle training compared to standard care on urinary incontinence in patients undergoing robot assisted radical prostatectomy and 2) to compare physical function, incontinence, and qol in two groups of patients with low or high function of the pelvic floor muscles respectively before the surgery. this study consists of two parts. the first part is a randomized controlled trial where 44 patients with weak pelvic floor muscle function are randomized to either treatment as usual (control group 1) or ultrasound-guided pelvic floor muscle training (intervention group). in the second part the patients in control group 1 will be compared with 22 patients with normal/strong pelvic floor muscle function (control group 2). patients not able to perform the pelvic floor muscle test consisting of 8 repetitions of 4-seconds pelvic floor muscle contraction and 1 repetition of 15-seconds pelvic floor muscle contraction will be randomized to either intervention group or control group 1. patients able to perform the pelvic floor muscle test will be included in control group 2.


Eligibility criteria:
inclusion criteria: * men aged 18 and above * diagnosis of prostatic adenocarcinoma and referred to robot assisted radical prostatectomy * no comorbidity that prevents pelvic floor training or effects the function of the pelvic floor * adequacy in written and spoken danish performance status 0-1 * able to understand the study procedures and willing to provide written informed consent exclusion criteria: * major surgery within the last month that may affect pelvic floor function. * urinary incontinence prior to surgery
brain metastasis in breast cancer patients

Conditions: Cancer

Summary: the purpose of this epidemiologic study is to establish a population-based cohort of women with advanced stage breast cancer which can be used to quantify the frequency and timing of brain metastases, and other distant metastases, in this patient population.

a retrospective cohort study will be conducted in the henry ford health system (hfhs). using medical record review, we will identify all women diagnosed with advanced stage (stage iii and iv) breast cancer between january 1, 1995- december 31, 2007. for each case included in the study, we will obtain data on demographics, tumor information, treatment related medical encounters and procedures, and occurrence and timing of brain and/or other distant metastases. the main outcome for this study is the development of distant metastases. each patient in the cohort will be classified as to the occurrence and date of distant metastases. metastases will be classified as brain, distant lymph node, lung/pleural effusion, liver, bone, other visceral, other non-visceral. other secondary outcomes to be explored include: * survival after advanced breast cancer-time in months from the date of advanced stage breast cancer diagnosis until death or end of study period * time to brain metastases-time in month from the date of advanced stage breast cancer diagnosis until brain metastases diagnosis * survival after brain metastases-time in months from the date of diagnosis of brain metastases until death or end of study period

Eligibility criteria:
inclusion criteria: * initially diagnosed with american joint commission on cancer (ajcc) stage iii or stage iv breast cancer between january 1, 1995 through december 31, 2007 -or- diagnosed with ajcc stage i or ii breast cancer and progressed to stage iii or iv disease between january 1, 1995 through december 31, 2007; * at least one year of follow-up after initial diagnosis (among patients who did not die before one year of follow-up); and * age 30 years or older at diagnosis. exclusion criteria: * does not have at least one year of follow-up after initial diagnosis (among patients who did not die before one year of follow-up); and * age less than 30 years or older at diagnosis.

Keywords: breast cancer treatment brain metastases erbb2 expression
docetaxel, cisplatin, and s-1 (tps) induction chemotherapy in locally advanced head and neck cancer

Conditions: Head and Neck Cancer

Summary: the purpose of this study was to evaluate the tolerability and efficacy of a combination of weekly docetaxel, cisplatin, and s-1 (weekly tps) as induction chemotherapy in patients with locally advanced head and neck squamous cell carcinoma (hnscc).

combination chemotherapy with cisplatin and fluorouracil (cf) is the standard treatment for patients with locally advanced squamous cancer of the head and neck. cf chemotherapy has been reported to increase survival and disease free survival in patients with unresectable disease when given before definitive radiotherapy, showing overall response rate as 75-85% including of cr rate of 25-35%. to improvement of treatment, docetaxel was incorporated into cf as induction treatment and it showed the prolongation of progression free survival and overall survival in large scale of randomized phase iii trials, therefore triple combination induction regimen would be standard treatment in advanced head and neck cancer. recently, the introduction of oral fluoropyrimidine showed similar or enhanced response rate, also favorable safety and convenience than intravenous fluoropyrimidine in advanced gastric cancer. of the oral fluoropyrimidines, s-1 showed promising preliminary result in combination chemotherapy with cisplatin in head and neck cancer. in patients with advanced gastric cancer, phase i study of s-1, docetaxel and cisplatin combination chemotherapy was reported and the recommended doses were 40mg/m2 bid, 60mg/m2 (d1) and 60mg/m2 (d1), respectively. therefore, the aim of this study was to evaluate the efficacy and safety of docetaxel, cisplatin and s-1 combination chemotherapy according to above dosage.

Eligibility criteria:
inclusion criteria: * locally advanced stage iii or iv squamous cell carcinoma of the larynx, oropharynx, or hypopharynx * ≥18 years old * absolute neutrophil count ≥1,500/µl, platelets ≥100,000/µl * serum bilirubin \<2.0 mg/dl * creatinine \<1.5 mg/dl * serum transaminase levels less than twice the upper limit of normal exclusion criteria: * received previous chemotherapy * another malignancy * current or history of distant metastasis * history of clinically significant cardiac disease within 6 months * active serious infection * nasopharyngeal carcinoma * psychiatric illness that would preclude obtaining informed consent

Keywords: head and neck cancer docetaxel cisplatin s-1