Kornimate/medical-research-clean huggingface dataset:
fascia transversalis versus transversus abdominis plane block for children undergoing inguinal hernia surgery

Conditions: Fascia Transversalis Plane Block

Summary: fascia transversalis block in pediatrics undergoing inguinal surgical repair may be simple technique and may give longer effect in reduction of post-operative pain in comparison to transversus abdominis plane block.

all children will be assessed clinically, and investigations will be done to exclude the exclusion criteria mentioned above. laboratory works needed: complete blood count (cbc), prothrombin time, concentration, partial thromboplastin time intra-operative management premedication by intramuscular injection of atropine 0.02 mg/kg and midazolam 0.2 mg/kg will be followed by insertion of intravenous (i.v) cannula. general anesthesia will be induced in supine position under standard basic monitoring of vital signs with inhalational anesthetic using (100%) o2 + sevoflurane. after deepening of the anesthesia, atracurium 0.5mg/kg and fentanyl 1μg/kg patients will be given, endotracheal intubation will then follow by appropriate size of endotracheal tube. volume control ventilation (vcv) 5-7 ml/kg and respiratory rate will be adjusted to keep and paco2 levels between 30-35 mmhg using (g.e-datex-ohmeda, avance cs2, usa) anesthesia machine. anesthesia will be maintained with isoflurane 1 mac with 50% oxygen in air, and atracurium top-ups of 0.1mg/kg will be given every 30 minutes for neuromuscular blockade. the block will be performed using sonosite s-nerve portable ultrasound and slax/13-6 mhz transducer will be used. 0.4 ml/kg bupivacaine 0.25% will be installed in the block plane. after receiving the block, surgical incision will be allowed to be done after 15 minutes. continuous recording of heart rate, blood pressure, will be carried out from the moment of injection at timely intervals intra-operative. increase of hr bp. \>30% of baseline indicates failure of block so fentanyl will be given at 1 mic / kg intra-operative. postoperative pain assessment using flacc score will then follow till 6 hours

Eligibility criteria:
inclusion criteria: * asa physical status i-ii exclusion criteria: * parents' refusal to participate in the study. * coagulopathy (i.e. platelets ≤ 50,000 and/or inr\> 1.5). * localized infection at the site of needle insertion. * known hypersensitivity or allergies to any of the used drugs.

Keywords: transversus abdominis plane block open inguinal herniorrhaphy
stroke and panorama - analyzing carotid endocalcifications (space)

Conditions: Carotid Stenoses

Summary: the odontological radiology method panorama is known to be able to spot calcifications in the area of the carotid arteries. the calcifications could be carotid stenoses which is affiliated with an increased risk of stroke. the study aims to investigate if panorama examinations can be used as a starting point for further investigation of the carotid arteries.

we intend to examinate 100 consecutive persons that have calcifications in the area of the carotid arteries with carotid duplex-ultrasound. the prevalence of carotid stenoses \> 50% (according to the nascet criteria) in this group is the primary result of interest, answering the most fundamental question - should persons with calcifications in the area of the carotid arteries seen on panorama be screened with ultrasound in order to find asymptomatic carotid stenoses? since the publication of the acst and the acas studies it is clear that some of these patients might have indications for surgery. a second part of the study aims to more fully understand what it is that the panorama examination reveals. in this part will 100 patients that are going to undergo surgery to remove their carotid stenoses will be examined with panorama. the carotid plaque that is removed during the surgery will be examined radiologically. primary endpoint: * subpopulation prevalence of carotid stenoses \> 50% in persons with calcifications in the area of the carotid arteries seen in a panoramic examination. secondary endpoints: * statistical data (sensitivity, specificity, accuracy, likelihood ratio and predictive values) for panorama to find carotid stenoses with ultrasound as gold standard. * qualitative description of the relationship between panoramic calcification images and the removed carotid plaques. amendment june 2011: the different arms of the study will be published seperately.

Eligibility criteria:
inclusion criteria: * panorama to ultrasound arm: * calcifications in the area of the carotid arteries seen och panorama * ultrasound to panorama arm: * known carotid stenosis \> 50% * must undergo carotid endoarterectomy after the panoramic examination exclusion criteria: * panorama to ultrasound arm: * previous cerebrovascular symptoms * below 18 or above 75 years of age * ultrasound to panorama arm: * below 18 or above 90 years of age

Keywords: panorama carotid stenoses
clinical performance evaluation of pefakit® pict® uc in vitro diagnostic medical device

Conditions: Thromboembolic Events

Summary: to demonstrate the substantial equivalence (se) of pefakit® pict® uc (test device, t) to aptt-sp (hemosil) (predicate device, p) in determining heparin levels in subjects undergoing heparin therapy in support of a united states food and drug administration (fda) 510(k) submission.

standard of care study. objective is to monitor the patients' heparin levels under treatment with continuous unfractionated heparin infusions. blood samples collections (4 ml) are required routinely. a proportion of this standard sample (leftover plasma) will be used for study purposes. about three samples will be analyzed which are collected within 2 - 4 days. time points for blood sample collections will be defined by the treating physician according the local standard of care and will be associated exclusively to clinical considerations. results of the pefakit® pict® uc assay will not be used to take therapeutic decisions for study subjects.

Eligibility criteria:
inclusion criteria: * subjects receiving a continuous infusion with ufh * subjects who have given written informed consent (unless written informed consent is waived by local regulations or local ec/irb) exclusion criteria: * subjects treated with any other anticoagulants other than ufh * subjects who have been undergoing fibrinolytic therapy within the previous 4 weeks * subjects who are known to have a congenital bleeding disorder * subjects known to present unexplained prolongations of clotting time * subjects known to have coagulation factor deficiencies * patient participating or who has participated within one month from enrolment in another investigational study

Keywords: determination of heparin levels patients requiring unfractionated
rehabilitation after lumbar disc surgery: exercise therapy and brief educational intervention

Conditions: Prolapse

Summary: rehabilitation after lumbar disc surgery (prolapse) focuses on various elements such as endurance, strength, stretching and information. evidence concludes that it is not harmful to return to activity after lumbar disc surgery, and restrictions to activities after these operations are today more or less nonexistent. some studies have shown that high intensity programs might be more effective, but they are probably more expensive. in recent years cognitive interventions have received more attention in rehabilitation programs after lumbar disc surgery. the cognitive approach is focused on providing patient knowledge to reduce uncertainty so that he or she can understand what is important after lumbar disc surgery so that belief in self-efficacy increases. a goal of the rehabilitation is to get the patient to resume normal activities. reviews ask for how much treatment are needed in a rehabilitation program after lumbar disc surgery. the study will be a randomized clinical trial. the study will compare two different post-operative rehabilitation programs (general information or general information + exercise therapy). both groups will begin treatment 1 day after surgery. subjects in exercise therapy group are supposed to continue with exercises 3 months. in this study the following hypothesis will be studied: 1. brief intervention, an educational model, alone after lumbar disc surgery do have the same effect on pain in legs and low back as brief intervention, an educational model, combined with exercise therapy. 2. exercises which are instructed after lumbar disc surgery in a rehabilitation program, are being done by the patients.


Eligibility criteria:
inclusion criteria: * diagnosed with lumbar disc prolapse with radicular pain * age between 18 and 60 exclusion criteria: * previous lumbar disc surgery (prolapse) * spondyloarthritis * arthritis * systematic disease * heart disease * does not understand norwegian language, spoken or in writing

Keywords: rehabilitation,surgery,brief intervention, exercises
mitochondrial dysfunction in trauma-related coagulopathy

Conditions: Trauma Induced Coagulopathy

Summary: bleeding control often poses a great challenge for clinicians due to trauma-induced blood clotting disorder (tic), a condition that is present in one-third of bleeding trauma patients. as platelets are considered as central mediators in tic, the understanding of mitochondria-mediated processes in thrombocytes may disclose new therapeutic targets in the management of severely injured patients. the investigators hypothesize that mitochondrial dysfunction occurs in the platelets of trauma patients with tic. the investigators intend to quantitatively characterize the derangements of mitochondrial functions in tic; and assess the relation between mitochondrial respiration and clinical markers of platelet function

hemorrhage control often poses a great challenge for clinicians due to trauma-induced coagulopathy (tic), a condition that is present in one-third of bleeding trauma patients. as platelets are considered as central mediators in tic, the understanding of mitochondria-mediated processes in thrombocytes may disclose new therapeutic targets in the management of severely injured patients. the investigators hypothesize that mitochondrial dysfunction occurs in the platelets of trauma patients with tic. the investigators intend to quantitatively characterize the derangements of mitochondrial functions in tic; and assess the relation between mitochondrial respiration and clinical markers of platelet function measured with aggregometry, viscoelastic tests and conventional laboratory analysis.

Eligibility criteria:
inclusion criteria: * trauma patients * injury severity score (iss) 16 or greater, * age of 18 years or greater, * hemorrhage confirmed with extended focused assessment with sonography in trauma (efast) or computer tomography (ct) exclusion criteria: -

Keywords: blood coagulation disorders wounds and injuries hemorrhage mitochondria blood platelet disorders thrombelastography coagulopathy, trauma induced
effect of galvanic vestibular stimulation on cortical excitability and hand dexterity in multiple sclerosis patients

Conditions: Cortical Excitability; Multiple Sclerosis

Summary: this study will be conducted to investigate the following: 1. the impact of implementing gvs in ms rehabilitation on cortical excitability. 2. the influence of gvs on upper limb function in patients diagnosed with ms. patients will be randomly assigned to a control group (conventional physical therapy program = cpt) and a study group (galvanic vestibular stimulation = gvs in addition to the conventional program) subsequently. cpt will perform moderate intensity aerobic training (arm ergometer) and task oriented hand manipulation training, while gvs will receive galvanic vestibular stimulation will be added to the conventional physical therapy program.


Eligibility criteria:
inclusion criteria: 1. patients with ataxic rrms type of both genders will be recruited. the last ms relapse occurred at least 3 months prior to the study. 2. patients' age will range from 20 to 45 years old. 3. ambulant patients who meet the level less than or equal to 5 on edss will be recruited. 4. patients' score on mini mental state examination should be \> 26. 5. mild or no spasticity (grade 1 or 1+) according to modified ashworth scale. 6. all patients must at least hold primary stage certificate of education from one of the egyptian educational authorities. 7. all patients can independently sign consent form exclusion criteria: * patients will be excluded if they have: 1. moderate to severe auditory or visual or cognitive impairment. 2. coexistence of other neurological diagnoses of central or peripheral nervous system (e.g. cerebrovascular stroke, vestibulopathy or polyneuropathy). 3. history of any problems that hinder conduction of aerobic training or magnetic stimulation (e.g. deep venous thrombosis, shunts and pacemakers).

Keywords: galvanic vestibular stimulation hand dexterity multiple sclerosis transcranial magnetic stimulation cortical excitability
examınatıon of sports injury anxıety level and sports injury preventıon awareness of unıversıty students partıcıpatıng in sports

Conditions: Sport Injuries

Summary: this study aimed to evaluate the concerns of university students who are involved in sports on more than one subject related to sports injuries (anxiety of losing ability, anxiety of suffering, anxiety of losing social support, etc.). in addition, in this study, the awareness of protection from sports injuries was evaluated in order to minimize sports injuries and create awareness of injury prevention, based on the idea that the athlete will be injured less with less anxiety in sports life.

regardless of the sport branch, athletes are likely to encounter many injury stories during their active sports life. stories of sports injuries cause anxiety in athletes. therefore, sports injury prevention awareness is important. this study aimed to evaluate and compare the anxiety about sports injuries and sports injury prevention awareness of university students studying in different faculties and practicing regular sports. personal information form, sports injury anxiety scale (sias) and sports injury prevention awareness scale (sipas) were used. there was no difference between university students from three different faculties who participated in sports in terms of the total scores of the sias and sipas (p\>0.05). it was determined that there was a significant difference between the students from three faculties in terms of the anxiety of losing ability (ala) parameter, which is one of the subscales of the sias (p\<0.05). in pairwise comparisons between the groups, a significant difference was found between the students of health sciences and medical faculties in the subscale of the sias-ala (p=0.001). university students who participated in sports from all three faculties included in the study had normal levels of anxiety about sports injuries and high levels of sports injury awareness. high sports injury awareness of students participating in sports may be an important factor for injury prevention. low levels of anxiety may also be associated with high levels of awareness.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the research * to be a student in one of the faculties of sports sciences, health sciences, engineering and medicine * participating in a regular sport branch exclusion criteria: * - being diagnosed with a chronic disease or regular medication use * not being a student in one of the faculties of sports sciences, health sciences, engineering and medicine * voluntary separation from employment * failure to complete the questionnaires to be applied within the scope of the study.

Keywords: awareness sport injury students
insulin resistance indices and coronary artery disease

Conditions: Insulin Resistance; Coronary Artery Disease

Summary: in this retrospective study from professor kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry. insulin resistance was calculated using laboratory data

this was an analytical cross-sectional retrospective study involving patients with suspected cad who underwent coronary angiography between december 2018 and may 2023. the information was obtained from patients referred to the outpatient cardiovascular clinic (professor kojuri cardiology clinic, shiraz, iran, www.kojuriclinic.com). data was extracted from professor kojuri cardiology clinic database, including patient's information about the clinical history, presence or absence of specific diseases, angiography/angioplasty results, medications, and laboratory values. a total of 14,708 patients who had undergone coronary angiography at least once were examined. after applying exclusion criteria, 1017 eligible cases were selected for data analysis. the following data was recorded for the included patients: demographic data, past medical history (such as dm, hypertension, etc.), systolic and diastolic blood pressure, weight and height, fasting plasma glucose (fpg), hemoglobin a1c (hba1c), total cholesterol (tc), triglyceride (tg), low-density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c), and serum creatinine (cr). body mass index (bmi) was calculated as weight (kg) divided by the square of height (m2). obesity was defined as bmi ≥ 30 kg/m2. laboratory values were selected from the time before angiography, and if not available, from the time shortly after the angiography. this helped us find those values which could best represent the metabolic state of patients at the time of angiography, while reducing the confounding effect of statin use.

Eligibility criteria:
inclusion criteria: * patients with age more than 18 years and having undergone coronary angiography exclusion criteria: * incomplete data * history of prior coronary angiography or revascularization (percutaneous coronary intervention (pci) or coronary artery bypass grafting (cabg)) * serum creatinine \&gt; 1.4 mg/dl * history of chronic kidney disease (ckd) * cancer,

Keywords: coronary artery disease insulin resistance triglyceride glucose index
efficacy of retreatments with intravitreal bevacizumab

Conditions: Age Related Macular Degeneration; Choroidal Neovascularization

Summary: choroidal neovascularization is a leading cause of visual loss in people older than 60 years and for its treatment there had been performed multicentric studies with lucentis (ranibizumab) with a significant improval of visual acuity. in our institution we evaluated efficacy of bevacizumab in several pathologies but we dont know what would be the results if we use the same dose several times. our purpose was to determine the efficacy of bevacizumab for improve or stabilize visual acuity with two or more intravitreal inyections of bevacizumab.


Eligibility criteria:
inclusion criteria: * \* any visual acuity * oct: central foveal thickness greater than 300 u or with evidence of subretinal fluid. * active angiogram leakage exclusion criteria: * \* basal inflammatory disease * endoftalmitis history * lesions bigger than 5400 u or with scarring greater than 50% of lesion.

Keywords: neovascularization
evaluating the effects of community delivery of malaria intermittent preventive treatment on pregnant women and babies

Conditions: Malaria in Pregnancy

Summary: this study evaluates the effectiveness of community delivery of sulfadoxine-pyrimetamine (sp) for intermittent preventive treatment of malaria in pregnancy (iptp) in increasing the coverage of iptp among pregnant women in selected districts in democratic republic of congo (drc), madagascar, mozambique and nigeria, compared to comparison districts where sp for iptp is distributed as usual in facilities through routine antenatal care (anc).

the specific objectives of this study are to determine the change in the following indicators during the course of the tiptop project: 1) proportion of women who have had a pregnancy that ended in the past 12 months and have received 1 or more, 2 or more and 3 or more doses of iptp-sp; proportion of women with pregnancy in the past 12 months who attended anc clinics at least once, and who attended at least four times; proportion of pregnant women attending the first anc visit before or at week 14; proportion of women who have had a pregnancy that ended in the past 12 months who know about the iptp service provided by chws; and acceptability of c-iptp for community delivery of iptp (note: results will be disaggregated by provider type, age, gravidity and distance from facility). to assess these changes, the study will implement structured household surveys targeting potential beneficiaries of the project (pregnant women) in the intervention and comparison areas, implemented at three time points: baseline, mid- and end-points. in each country an initial implementation area (phase i) and two expansion areas (phase ii) have been selected for the project. this study will establish if community deliver of iptp is effective and feasible and whether it influences antenatal care service coverage rates. it is expected that the study will provide information to scale up the approach the 4 study countries for the prevention of malaria in pregnancy. this information is also meant to inform global guidelines on community iptp delivery and may also be used by other countries.

Eligibility criteria:
inclusion criteria: * women who had a pregnancy that ended in the 12 months preceding the survey * being resident in the study area during for at least 4 months before the end of the pregnancy * willing to participate in the household survey (signing informed consent/assent, in line with country guidelines) exclusion criteria: * anyone considered to be a minor in their country. * not willing to provide informed consent