Kornimate/medical-research-clean huggingface dataset:
the use of mole mapping diagrams to increase skin self examination accuracy

Conditions: Melanoma

Summary: this study aims to improve skin self-examination accuracy by a simple cost effective intervention requiring participants to complete a mole-mapping diagram.


Eligibility criteria:
inclusion criteria: * male and female subjects above age 18 of any ethnicity will be enrolled in this study. exclusion criteria: * subjects will be excluded from the study if they have significant skin disease which would not allow manipulation of their photographs consistent with the rest of the subjects. * since the study instructions are in english, non-english speakers will be excluded. * those with co-morbidity sufficiently severe to prevent them from being able to perform a sse will be excluded. * in addition, those with cognitive impairment who are unable to give informed consent, or to understand the study instructions given to them, will be excluded.

Keywords: skin self examination mole mapping diagram melanoma
adjuvant docetaxel-zoledronic acid in high-risk early prostate cancer following prostatectomy.

Conditions: Prostate Cancer

Summary: radical prostatectomy is used to treat early prostate cancer in otherwise well men, but is followed by later cancer relapse in 1 in 4 cases. this study aims to see if post-operative adjuvant therapy with a combination of zoledronic acid and docetaxel might help reduce relapse in such cases. patients will be randomized to receive the adjuvant combination therapy or no therapy. all patients will be monitored closely for signs of relapse and treated appropriately with conventional salvage therapy.


Eligibility criteria:
inclusion criteria: * radical prostatectomy for prostate cancer within last 2 months. * post-operative kattan nomogram predicts \>25% risk of psa relapse by 5 years. * 6-week post-operative serum psa\<0.2ng/ml. * low levels of circulating prostate cancer cells in the blood, detected by pcr amplification of psa mrna 6 weeks post-prostatectomy. exclusion criteria: * pre-operative serum psa level \>20ng/ml. * clinical evidence of metastases by 6-week post-operative visit. * prior treatment with either adt or bisphosphonate therapy. * current active dental problems including infection of the teeth or jawbone (maxilla or mandibular); dental or fixture trauma, or a current or prior diagnosis of osteonecrosis of the jaw (onj), of exposed bone in the mouth, or of slow healing after dental procedures. * recent (within 6 weeks) or planned dental or jaw surgery (e.g.extraction, implants) other protocol defined inclusion / exclusion criteria may apply.

Keywords: zoledronic acid prostate cancer high risk psa docetaxel
prospective validation of pathology-based artificial intelligence diagnostic model for lymph node metastasis in prostate cancer

Conditions: Prostatic Neoplasms; Lymphatic Metastasis

Summary: the goal of this diagnostic test is to prospectively test the performance of pre-developed artificial intelligence (ai) diagnostic model for detecting pathological lymph node metastasis (lnm) of prostate cancer. investigators had developed this ai model based on deep learning algorithms in preliminary research, and it performed well in retrospective tests. investigators will compare the diagnostic performance (sensitivity, specificity, etc.) of the ai model and routine pathological report issued by pathologists, to see if the ai model can improve the clinical workflow of pathological evaluation of lnm in prostate cancer in the real world.

lymph node metastasis (lnm) is a common mode of metastasis in prostate cancer, and accurate postoperative pathological lymph node staging is of great significance for further treatment and prognosis assessment. however, the current pathological evaluation of lymph nodes relies on manual examination by pathologists, which has a relatively low diagnostic efficiency and is prone to missed-diagnosis for micro metastatic lesions. therefore, investigators developed an ai diagnostic model for detecting pathological lymph node metastasis of prostate cancer based on deep learning algorithms in preliminary research, and it performed well in retrospective tests. this study is a diagnostic test with no intervention measures, planning to collect pathological slides of formalin-fixed, paraffin-embedded lymph nodes resected from the enrolled patients and digitise them into whole-slide images (wsis). the ai model will analyse the wsis and generate pixel-level heatmaps and slide-level diagnostic results (with or without lnm). the routine pathological examination will be performed as usual. these two processes will not interfere with each other. and if there are inconsistency in slide-level classification between ai and routine pathological examination, investigators would convene senior pathologists for discussion to make the final decision (immunohistochemistry would be performed if necessary). the final result will be presented to the patient in the form of a pathological report.

Eligibility criteria:
inclusion criteria: * patients with prostate cancer, undergoing radical prostatectomy and pelvic lymph node dissection. * patients with complete clinical and pathological information. exclusion criteria: * patients with other tumors that metastasized to pelvic lymph nodes. * the patient refused to participate in this diagnostic test.

Keywords: artificial intelligence lymph node metastasis prostate cancer whole slide image
development of alternatives for the estimation of the resting metabolic rate from anthropometry in paralympic athletes

Conditions: Resting Metabolic Rate; Disability Physical; Athletic Injuries

Summary: to our knowledge no study has evaluated neither feasible methods for the assessment of anthropometric profile nor indirect methods to estimate energy expenditure (ee) for adapted athletes. the primary aim is to develop and validate new rmr prediction models, for the estimation of the resting metabolic rate from anthropometric variables in young mexican paralympic athletes; our second objective is to evaluate the agreement between rmr and the prediction models of cunningham, harris-benedict, henry, valencia, chun, nightingale \& gorgey, fao/who, mifflin, müller, owen, and our own models. a comparative cross-sectional quantitative study was designed. participants report to the testing laboratory only once for data collection. the strengthening the reporting of observational studies in epidemiology criteria guidelines for cross-sectional research (strobe) is followed in the design/reporting of this study.


Eligibility criteria:
inclusion criteria: i) swimmers who report to the assessment area with a fasting period of 6 to 8 hours, and at least 12 hours after their last exercise routine; ii) swimmers who have not consumed alcohol or any stimulant for the last 48 hours (e.g., coffee, tea, chocolate, carbonated drinks, energy drinks, supplements); iii) swimmers who has contested at least in one of the last two swimming competitions, including world championships and paralympic games exclusion criteria: i) fail to complete the indirect calorimetry test after two attempts; ii) attend to the evaluation area without the appropriate clothing or without following the instructions for fasting, exercise, and feeding prior to the evaluations; iii) swimmers who at the time of the evaluations did not give written consent (parental consent in case of under 18 years old) for procedures or data release for research purposes.

Keywords: anthropometry indirect calorimetry bioenergetics metabolic rate paralympic athletes
our anesthesia experiment applied to child earthquake victims in the february 6, 2023 earthquake

Conditions: Earthquake; Crush Injury; Anesthesia

Summary: the study aimed to investigate anesthesia management of pediatric patients in the ankara bilkent city hospital during the earthquake disaster of february 6.

in this study, the investigators planned to retrospectively investigate the anesthesia management of pediatric patients who were transferred to or admitted to the ankara bilkent city hospital in the earthquake disaster of february 6. the anesthesia data on pediatric earthquake victims were insufficient in the literature.the investigators aimed to share our experiences to guide anesthesia management in future possible disasters.

Eligibility criteria:
inclusion criteria: * child earthquake victims between the ages of 0-18 * participants who had surgery and anesthesia between 9 february 2023 and 9 august 2023 exclusion criteria: * the exclusion criterion is child earthquake victims patient who did not undergo anesthesia.

Keywords: pediatric trauma earthquake anesthesia
autologous vs. implant-based breast reconstruction

Conditions: Breast Cancer

Summary: although breast reconstruction is an integral part of breast cancer treatment, there is little high-quality evidence to indicate which method is the most effective. the objective of this study is to compare implant-based and autologous breast reconstruction, in non-radiated patients. the primary outcome is patient reported breast-specific quality of life/satisfaction and the secondary outcomes are complications, factors affecting satisfaction, and cost-effectiveness. moreover, the study aims to improve the evidence for trial decision-making in breast reconstruction. randomized controlled trials (rct) are generally thought to provide the most solid scientific evidence, but there are significant barriers to conducting rcts in breast reconstruction, making both recruitment and achieving unbiased and generalisable results a challenge. the study design partially randomised patient preference trial (rppt) might be a way to overcome these challenges. in the present study, patients who consent to randomisation will be randomised to implant-based and autologous breast reconstruction, whereas patients with strong preferences will be able to choose method. the study is designed as a superiority trial based on breast-q and 124 participants will be randomised. in the preference cohort patients will be included until 62 participants have selected the least popular alternative. follow-up will be 60-months. embedded qualitative studies and within-trial economic evaluation will be performed.


Eligibility criteria:
inclusion criteria: * biological female * \>18 years of age * american society of anesthesiologist classification (asa) 1-2 * patient must have had or be scheduled for a mastectomy * ability to give informed consent * ability to communicate in swedish exclusion criteria: * asa \> 2 * bmi \> 30 kg/m2 * smoking1 radiotherapy to the breast in question. * radiotherapy is expected post-operatively. * locally advanced breast cancer * metastasised breast cancer * comorbidity and/or drugs that affect wound healing. * unstable psychiatric co-morbidity * abdominal scaring/chest scaring making a diep/implant-based reconstruction unsuitable

Keywords: breast reconstruction diep-flap implant-based breast reconstruction
pregnancy-related low back pain and complementary and alternative medicine (cam) treatment

Conditions: Low Back Pain

Summary: this study compares three treatments for low back pain that started during pregnancy. the study hypothesizes that exercise, spinal manipulation, and a mind-body technique called neuroemotional technique (net) equally affect pain intensity and disability associated with pregnancy-related low back pain. the study also hypothesizes that pain intensity and disability levels do not influence maternal heart rate variability (a measure of stress) and intrauterine attachment (a measure of relationship quality). ten women will additionally provide blood and salivary oxytocin samples during pregnancy and periodically for three months after birth. these women and their babies will also be videotaped playing for 5 minutes at 2 weeks, 6 weeks, and 3 months postpartum.

pregnancy-related low back pain is experienced by over half of all pregnant women. in the united states it is thought of as a normal constituent of pregnancy. however, in europe low back pain associated with pregnancy is treated. in the united states pregnancy-related low back pain is thought to resolve with birth. however about 1/3 of women who experience pregnancy-related low back pain continue to experience back pain for one year postpartum. those women whose low back pain persists into the postpartum period are more at risk of experiencing comorbidities such as postpartum depression. in the extrauterine life maternal pain limits a mother's ability to securely attach with her child. furthermore, interpretation of pain intensity is influenced by the type of attachment the individual has with her parents. little is known how maternal pain may influence intrauterine attachment. similarly, heart rate variability is influenced by pain and by spinal manipulation in non-pregnant populations. however, normal non-pregnant patterns of heart rate variability are altered during the second and third trimesters of pregnancy, and little is known about why this happens or what this means.

Eligibility criteria:
inclusion criteria: * healthy * 20-49 years old * pregnant with a singleton * low back pain began during pregnancy and has lasted more than one week * low back pain is reproducible with palpation exclusion criteria: * health conditions such as hypertension, diabetes, cancer, thyroid condition etc. * pain radiates below knee * cannot read english * plans to move away from portland area during pregnancy * not willing to be randomized to one of the three arms of the study

Keywords: pregnancy pain low back pain pubic symphysis pain cam complementary & alternative medicine exercise chiropractic spinal manipulation adjustments neuroemotional technique mind body mind body therapy attachment maternal fetal relationship intrauterine attachment heart rate variability vas visual analog scale roland morris disability index
comparison of fdg and fapi in patients with various types of cancer

Conditions: Tumor, Solid; Positron-Emission Tomography; Metastasis

Summary: to evaluate the potential usefulness of 68ga-dota-fapi-04 positron emission tomography/computed tomography (pet/ct) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with 18f-fdg pet/ct.

subjects with various types of cancer underwent contemporaneous 68ga-dota-fapi-04 and 18f-fdg pet/ct either for an initial assessment or for recurrence detection. tumor uptake was quantified by the maximum standard uptake value (suvmax). the sensitivity, specificity, positive predictive value (ppv), negative predictive value (npv) and accuracy of 18f-fdg and 68ga-dota-fapi-04 pet/ct were calculated and compared to evaluate the diagnostic efficacy.

Eligibility criteria:
inclusion criteria: * (i) adult patients (aged 18 years or order); (ii) patients with suspected or newly diagnosed or previously treated malignant tumors (supporting evidence may include magnetic resonance imaging (mri), ct, tumor markers and pathology report); (iii) patients who had scheduled both 18f-fdg and 68ga-dota-fapi-04 pet/ct scans; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the clinical research ethics committee. exclusion criteria: * (i) patients with non-malignant lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.

Keywords: positron-emission tomography tumor, solid diagnosis metastasis
effects of traditional martial arts, open and locked exercise on the physical and mental health of drug users

Conditions: Drug Use

Summary: the aim of this study is to discuss the efficacy of chinese traditional martial arts in reducing drug addiction and improving the physical and mental health of drug addicts.


Eligibility criteria:
inclusion criteria: * normal mental state, able to understand and accept instructions * drug users who have survived the detoxification period * without major diseases exclusion criteria: * drug use for more than 2 years * drug abusers who have entered a drug rehabilitation center more than once
the effect of medication review in high-risk emergency department patients

Conditions: Adverse Drug Events; Adverse Drug Reactions; Medication-related Problems

Summary: adverse drug events are unintended and harmful events related to medication use and a leading cause of emergency department visits, unplanned hospital admissions and deaths. in the emergency department, physicians frequently misdiagnose adverse drug events leading to treatment delays. our objective is to evaluate the effect of pharmacist-led medication review in high-risk emergency department patients on prolonged hospital stay. this prospective multi-centre, quasi-randomized study is nested within an existing quality improvement program. triage nurses flag incoming emergency department patients at high-risk for adverse drug events by applying a clinical decision rule consisting of four variables (co-morbid conditions, antibiotic use within 7 days, medication changes within 28 days, and age). consecutive eligible high-risk patients are enrolled into the medication review study, and systematically allocated to pharmacist-led medication review or usual care. in the intervention group, medication review pharmacists collect best-possible medication histories, review the patient's medications for appropriateness and adverse drug events, and communicate the results of medication review to patients, caregivers and physicians. in the usual care group, physicians refer patients to onsite pharmacists for medication management questions on an as needed basis. health outcomes are assessed using anonymized data linkage to administrative health databases. the primary outcome is the percent of days spent in hospital during the first 30 days after the index emergency department visit


Eligibility criteria:
inclusion criteria: consecutive high-risk patients, aged 19 years or older, presenting to a participating emergency department when a medication review pharmacist is on duty are eligible for enrolment. exclusion criteria: we will exclude patients categorized as canadian triage acuity score (ctas) 1 as they require immediate resuscitation, those presenting for multisystem trauma (e.g., penetrating trauma), scheduled visits (e.g., for intravenous antibiotics), sexual assaults, pregnancy-related complications, social problems, and those for whom we cannot link data to administrative records (e.g., out-of-province patients).
efficacy and safety of aju-c52 in essential hypertension patients

Conditions: Essential Hypertension

Summary: a randomized, double-blind, multi-center, phase iii study to evaluate the efficacy and safety of the aju-c52 compared with the combination of c52r1m in patients with essential hypertension patients who have inappropriately controlled on c52r1l treament


Eligibility criteria:
inclusion criteria: * adults aged ≤19 years. * those who voluntarily signed the informed consent to participate in this study. * a patient diagnosed with essential hypertension or patients taking hypertension medication * those who are eligible for adequate blood pressure criteria during screening tests: naïve patient-160 mmhg≤mssbp\<200 mmhg and msdbp\<110 mmhg/patients taking hypertension medication-140 mmhg≤mssbp\<200 mmhg and msdbp\<110 mmhg exclusion criteria: * at the screening visit (visit 1), patients had 3 blood pressure measurements in the arm with the higher average mssbp, those whose maximum and minimum blood pressure differences are mssbp 20 mmhg and msdbp 10 mmhg * secondary hypertension patients or those with a history of suspected secondary hypertension * cardiovascular/cerebrovascular disease * those with a history of malignant tumor within 5 years
risk factors for enhanced inflammation to arthroplasty wear particles: analysis of cytokine production and polymorphisms

Conditions: Allergy; Implants

Summary: assessment of cytokine polymorphisms in 100 patients with aseptic complications to arthroplasty as compared to 100 symptom-free arthroplasty patients. in selected patients additional in-vitro cytokine release assay with peripheral blood mononuclear cells (pbmc) stimulated with different wear particles.

a cytokine polymorphism analysis in 100 individuals with aseptic implant intolerance reaction (patients of the implant allergy special ambulance) and in 100 asymptomatic patients with implanted endoprostheses will be done. furthermore, supplementary clinical data (such as type of implant, hospital stay, discomfort), questionnaire-based history and a clinical score (womac score) are recorded. in the subgroup analysis in 10 patients of implant patients with complaints with special found cytokine polymorphisms and 10 implant patients without problems the cytokine response to particles in vitro will assessed. test parameters: 1. total collective: the dna of cryopreserved blood sample will be isolated. by polymerase chain reaction, four different known polymorphisms will be analyzed, three il-1b genes (il-1b-3954 il-1b-31, and il-1b-511), and a il-1ß receptor antagonist gene (il -1-rn, intron 2 vntr). molecular analysis includes dna isolation, polymerase chain reactions (pcr) and gel electrophoresis. 2. subgroup analysis: peripheral blood cells will be isolated from 10 implant patients with complications and 10 symptom-free persons and stimulated in cell culture with control stimuli, the il-1ß-inducer lipopolysaccharide (lps) and ceramic particles (biolox delta)\*, cocrmo particles and xpe-particles\*\* cultured separately or in combination. the secretion of il-1ß and selected proinflammatory cytokines will be measured. the methods include cell isolation by density centrifugation and analysis of cell culture supernatants by a multiplex cytokine measurement assay by flow cytometry. \* supplied ceramtec \*\* generated and processed by the working group of the cooperation partner prof. r. bader (university hospital rostock) in special carrier system for cell culture stimulation approach

Eligibility criteria:
inclusion criteria: * arthroplasty * over 18 years * no infection exclusion criteria: * inability to consent * malposition * infection

Keywords: implant allergy particle cytokine