Kornimate/medical-research-clean huggingface dataset:
the effect of prenatal haptonomy on anxiety, distress and psychological well-being

Conditions: First Pregnancy

Summary: introduction:anksiyete experienced during prenatal can increase distress, cause negative perinatal outcomes, and adversely affect the psychological well-being. this study will conducted to determine the effect of prenatal haptonomy on pregnancy-related anxiety, distress and psychological well-being. methods: the population of the randomized controlled experimental study will consist of 102 primiparous pregnant women within the gestational weeks 22-27 who presented to the pregnant school of a state hospital in turkey (34 first experimental group, 34 second experimental group, 34 control group).

background: anksiyete experienced during prenatal can increase distress, cause negative perinatal outcomes, and adversely affect the psychological well-being. aim: this study will conducted to determine the effect of prenatal haptonomy on pregnancy-related anxiety, distress and psychological well-being. metod: for the educational study of the research, the midwife working in the pregnant class will be interviewed and informed about it. the mat and seat cushions in the pregnant class will be arranged by the researcher in a way that is suitable for the application. music will be played during the application. wellness music recommended by the haptonomy trainer will be selected for the music (rathfisch, 2019). haptonomy application is planned to be performed individually with pregnant women. pregnant women in the experimental group 1 and 2 will be given the haptonomy application together with the trainings (standard care practices) in the pregnant class, and the pregnant women in the control group will only be trained in the pregnant class. pregnant class trainings include reproductive health physiology, problems that can be seen in pregnancy, birth process, newborn care, covering the prenatal period, birth and postpartum period. haptonomy- first experimental group: haptonomy group pregnant school will made to the experimental group, and haptonomy will be applied for at least 30 minutes, once a week for 6 weeks (with the researcher). haptonomy- second experimental group: haptonomy group pregnant school will made to the experimental group, and haptonomy will be applied for at least 30 minutes, once a week for 3 weeks (with the researcher). haptonomy- control group: standard of care group the control group will not be interfered with.

Eligibility criteria:
inclusion criteria: * primiparous pregnant women who were married, * aged 18 years and over, * literate, * living in the city center, * not having any health problems in themselves and their infants, * with spontaneous pregnancy at 22-27 weeks of gestation, * without perception and communication problems, * and who agreed to participate in the study were included in the study. exclusion criteria: • multiparity

Keywords: haptonomy distress psychological well-being anxiety
evaluation of new diagnostic methods of cardio-embolic related (atrial fibrillation) cerebral infarction

Conditions: Stroke

Summary: the aim of the study is to estimate the contribution of abdominal imaging by magnetic resonance imaging (mri) and abdominal scanner in the detection of subdiaphragmatic infarction associated to the atrial fibrillation in the cerebral infarction.


Eligibility criteria:
inclusion criteria: * patient over 18 * patient having a chads-vasc score ≥ 2; * patient hospitalized for a secondary established ischemic accident in an atrial fibrillation not anticoagulated (inr\<2 and/or receiving antiplatelet (aspirin, clopidogrel)) for less than 14 days; * patient affiliated to a national insurance scheme or beneficiary * patient having given a written consent exclusion criteria: * patient presenting cognitive disorders incompatible with the planned examinations (mri / scanner). * pacemaker or implantable defibrillator, or other contraindication in the mri (metallic eye brightness, intra cerebral clip). * contraindication in injected scanner. * current pregnancy

Keywords: subdiaphragmatic infarction
a study on the safety of administering rituximab at a more rapid rate in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this study was designed to evaluate the safety of administering rituximab at a more rapid infusion rate in patients with moderate to severe rheumatoid arthritis who have had an inadequate response to biopharmaceuticals that treat diseases by interfering with tumor necrosis factor (anti-tnf therapies), and were receiving methotrexate therapy for more than eight weeks.


Eligibility criteria:
key inclusion criteria: * adult patients, ≥ 18 years of age * rheumatoid arthritis of ≥ 6 months duration, diagnosed according to the revised 1987 american college of rheumatology criteria * inadequate response to at least one approved anti-tnf agent (adalimumab, etanercept, infliximab, golimumab, or certolizumab) * patients who have received 1 to 2 prior courses of rituximab (rtx) may be enrolled, provided their most recent course of rtx occurred over 6 months but no more than 9 months prior to baseline. the rtx dosage must have been two 1000 mg infusions per course administered at the standard approved rate * methotrexate treatment between 10 and 25 mg/week (oral or parenteral) for at least 8 weeks immediately prior to baseline key exclusion criteria: * major surgery (including joint surgery) within 8 weeks prior to screening or planned surgery within 6 months following baseline * rheumatic autoimmune disease other than rheumatoid arthritis * functional class iv as defined by american college of rheumatology (acr) criteria * prior history of or current inflammatory joint disease other than rheumatoid arthritis * history of severe allergic or anaphylactic reactions to human, humanized or murine monoclonal antibodies * previous serious infusion reaction to any prior biologic therapy * known active current or history of recurrent infection * evidence of chronic hepatitis b or c infection * pregnant or lactating women * body weight of \> 150 kg
an attempt to find out root cause of a pain producing knee disease

Conditions: Knee Osteoarthritis; Arthroplasty; Knee

Summary: this study was focused on a type of arthritis (knee) in which patients develop pain with disabilities in sitting and walking etc. in advance stage the person is bereft of his/her personal physical activities. the prevalent treatment is temporary and dis-satisfactory. a new treatment was designed and a trial was conducted on 125 patients (100 in the trial group, 25 in the control group) for a duration of six months.

the study was focused on establishing the cause and treatment of a painful knee joint disease (primary osteoarthritis knee = oa knee). at present the cause and treatment are not known. the study was based on a hypothesis, designing a treatment and testing it through a clinical trial. this established that the deficient full flexion or deficient full extension of knee joints, producing contracture in their capsules was the cause and the correction (contracture correction therapy = cct) was the cure of the disease. the correction was carried out by passive flexion or passive extension of affected knee through eight body postures designed specifically during the study. to test the efficacy a multi-centre, multi surgeon six months study on 125 patients was carried out, patients were divided into trial and control groups. the effects were measured by primary outcome measure - the western ontario and mcmaster universities arthritis index (womac) score and other measure euroqol-visual analogue scales (eq-vas) score, dff\*, dfe\^ at 0, 6 ,12 and 24 weeks. the "intervention" for 1st group was cct and for the 2nd group was "no intervention". \* deficient full flexion \^ deficient full extension

Eligibility criteria:
inclusion criteria: * age =\>30 years * knee pain which appeared without any apparent cause, exacerbated by exertion and subsided by rest. * presence of limited morning stiffness * no history of infection, inflammation or trauma to rule out secondary oa * disability in sitting, climbing stairs or walking exclusion criteria: * backache * leg pain (e.g. sciatica) * inability to lie supine (e.g. kyphosis) * inability to lie prone (e.g. central obesity)

Keywords: deficient full flexion deficient full extension contracture correction therapy
acticoat absorbent and bct antimicrobial for stsg donor site on thigh

Conditions: Wound Healing; Wound Infection; Pain; Pruritus; Cicatrix

Summary: this study aims to compare the effectiveness of two wound dressings, acticoat absorbent (aa) and bct antimicrobial (bct) on split thickness skin graft (stsg) donor site.

seventy patients who undergo stsg procedure in kaohsiung veterans general hospital will be recruited. two donor sites of equal lengths and widths on the same thigh, which are at least 2 cm apart will be covered randomly with aa and bct each. wound healing rate and infection rate will be assessed at 7 and 14 days after surgery. degrees of pain and itchiness will be assessed daily with visual analogue scale for the first 7 post-operative days. scar appearance will be assessed with vancouver scar scale 1, 3 and 6 months post-operatively.

Eligibility criteria:
inclusion criteria: * patients who need stsg, longer than 8 cm and wider than 5 cm, from their thighs exclusion criteria: * systemic steroid * old scar on thigh * systemic infection * anticipated use of antibiotics for more than 24 hours after operation * pregnancy * previous chemotherapy within 3 months before operation * anticipated chemotherapy within 3 months after operation * not over 20 years old * non-communicable * burn area more than 20% total body surface area * systemic auto-immune disease * liver cirrhosis * allergy to carbon fiber or alginate * anticipated mri study * dry wound

Keywords: wound healing wound infection pain pruritus cicatrix dressings acticoat absorbent bct kocarbonag
"platelet-rich plasma" epidural injection an emerging strategy in lumbar disc herniation

Conditions: PRP

Summary: to evaluate the efficacy of platelet-rich plasma (prp; double-spin) in treatment of single-level lumbar herniated nucleus pulposus (hnp) in comparison to triamcinolone. rct was conducted with 30 patients included.

the study was a randomized controlled trial, triple-blind, single-center/surgeon/assessor. the study was conducted between april 2019 to may 2021. we evaluated 30 patients (both genders) aged 20-55 years, having failed conservative treatment of unilateral hnp undergone for at least 6 weeks, with visual analogue scale (vas) of greater than 30, and confirmed a single-level hnp, corelated to clinical, by mri. the exclusion criteria included previous spine surgery or epidural injection, progressive neurological deficit, cauda equina, coagulopathy-related conditions, associated cervical myelopathy, systemic bone and joint diseases. all patients had to have been exempted from nsaids for at least one week. patients were treated by transforaminal epidural injections. fifteen patients were in triamcinolone and prp groups each. prp was obtained from 24 ml venous blood through standardized double-spin protocol. participants were fifteen patients each in triamcinolone and prp groups. the same postoperative protocols and medications were applied. the visual analogue scale of leg (legvas), collected at baseline, 2, 6, 12, and 24 weeks, was the primary outcome. the backvas, oswestry disability index (odi), adverse event, and treatment failure were the secondary endpoints. all subjects were analyzed according to the intention-to-treat principle. all statistical analyses were performed with stata 17.

Eligibility criteria:
inclusion criteria: * age 20-55 years * having failed conservative treatment for at least 6 weeks * visual analogue scale (vas) of greater than 30 * confirmed a single-level hnp, corelated to clinical, by mri. exclusion criteria: * previous spine surgery or epidural injection * progressive neurological deficit * cauda equina * coagulopathy-related conditions * associated cervical myelopathy * systemic bone and joint diseases

Keywords: prp, hnp, lumbar hnp
trial evaluating efficacy and safety of nivolumab (optivo®) in patients with covid-19 infection, nested in the corimmuno-19 cohort.

Conditions: COVID19- Infection With SARS-CoV-2 Virus

Summary: it appears interesting to use nivolumab in severe patients infected with sars-cov-2 requiring hospitalization in conventional unit or in icu. this protocol corimuno19-nivo therefore, will evaluate the efficacy and safety of optivo® (nivolumab) covid-19 patients hospitalized in conventional unit. the purpose of this study is to show the efficacy of nivolumab in patients with covid-19 in combination with standard treatments. a phase 2 randomized open trial will evaluate the efficacy and safety of optivo® (nivolumab) alone versus standard of care (soc) in patients hospitalized in conventional units. patients will be randomly allocated 1:1 to either nivolumab or soc.


Eligibility criteria:
inclusion criteria: * adults (men and women) age over 18 years old * at least one nasal swab positive for covid-19 detected by pcr, maximum 7 days prior to treatment * viral pneumonia confirmed by tdm scan * patients meeting all of the following 3 criteria: * requiring more than 3l/min of oxygen * who progression scale = 5 * no niv or high flow exclusion criteria: * patients with active cancer and immunocopromised patients * known hypersensitivity to nivolumab or to any of their excipients. * pregnancy * patient with an autoimmune or inflammatory disease (including but not limited to: crohn's disease, rheumatoid arthritis, scleroderma, systemic lupus erythematosus, grave's disease). patients with thyroiditis or vitiligo only could be included. * patient with a history of thymoma * patient with a history of solid organ transplantation or a bone marrow transplantation * patients treated with immune checkpoint inhibitors 3 months prior to the study * patients who had a history of grade 3 or 4 immune-related adverse events with a previous treatment with immune-checkpoint inhibtors * patients requiring icu based on criteria of severity of covid pneumopathy * respiratory failure requiring mechanical ventilation or extracorporeal membrane oxygenation
aim covid self monitoring

Conditions: Covid19

Summary: the objectives of this study are to test the level of accuracy of the prediction models that could be used as a 'digital test' to evaluate whether an individual is infected with covid-19, based on their symptoms reported in the "aim covid-19" app


Eligibility criteria:
inclusion criteria: * participants resident in india * voluntary completion of the self-test and evaluation. exclusion criteria: * people can not use mobile app * below 18 years old
textbook outcomes in urgent appendectomy

Conditions: Valid MeSH Conditions

Summary: a "textbook outcome" patient is defined as one whose surgical course is uneventful, with no complications, readmissions, or mortality. there is a lack of published research regarding textbook outcomes with an acute appendicitis that are treated with an appendectomy.

the objective of this study is to analyze the attainment of textbook outcomes (to) in patients undergoing urgent appendicectomy (ua) for acute appendicitis and to identify the factors associated with achieving to.

Eligibility criteria:
inclusion criteria: * acute appendicits in older than 18 years old * acute appendicitis that needs appendectomy exclusion criteria: * age under 18 years old * other diagnostic than an acute appendicitis

Keywords: textbook outcomes laparoscopy acute appendicitis open surgery urgent appendectomy
increased physical activity in african-american women

Conditions: Cardiovascular Diseases; Heart Diseases

Summary: to conduct a randomized demonstration and education trial of churches in east baltimore testing a self-help, minimal intervention compared with an intensive physical activity intervention.

background: the study filled an existing gap by examining how a culturally sensitive physical activity intervention conducted in a community setting was associated with increased daily energy expenditure in african american women -- a group of women who are sedentary and at risk for health problems for which regular physical activity can provide benefits. design narrative: an evaluation was conducted of the effectiveness of a six-month moderate-intensity physical activity intervention for increasing total daily energy expenditure of sedentary african-american women who were between the ages of 50 and 70 years. the goal of the intervention was to increase total daily energy expenditure by 150 kilocalories per day and time spent in moderate-intensity physical activity by 30 minutes per day. effects of increased physical activity on selected cardiovascular risk factors (e.g., peak oxygen uptake, blood pressure, hdl cholesterol, serum insulin and plasma glucose) were also determined. six churches were randomized into intensive or minimal intervention status, and 33 women per church were recruited, for a total of 100 women in each condition. the physical activity intervention consisted of twice-weekly aerobics classes conducted at the churches and additional group-and home-based programming. volunteer lay leaders were trained as neighborhood exercise specialists to supplement certified aerobics instructors in conducting the intervention. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
safety and efficacy of remote ischemic conditioning in patients with chronic internal carotid artery occlusion receiving hybird surgery: a pilot, randomized controlled trial

Conditions: Carotid Artery Occlusion

Summary: the purpose of this study is to explore the safety and efficacy of remote ischemic conditioning in patients with internal carotid artery occlusion receiving hybird surgery.

in this study, 60 patients with internal carotid artery occlusion receiving hybird surgery are included in our center in china. the experimental group will receive basic treatment and remote ischemic conditioning for 200mmhg, 2 times per day for 6 consecutive days. the control group will receive basic treatment and remote ischemic conditioning control for 60mmhg, 2 times per day for 6 consecutive days. two groups will be followed up for 90 days to evaluate the safety and efficacy of remote ischemic conditioning in patients with internal carotid artery occlusion receiving hybird surgery.

Eligibility criteria:
inclusion criteria: * age≥18 years, regardless of sex * patients with chronic carotid artery occlusion who are going to undergo hybird surgery * can cooperate with and complete brain magnetic resonance imaging (mri) examination * signed and dated informed consent is obtained exclusion criteria: * hemorrhagic stroke * severe cardiac dysfunction or arrhythmia * uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmhg or diastolic blood pressure ≥ 110 mmhg, despite medication taken at enrollment) * severe hepatic and renal dysfunction (defined as aspartate aminotransferase (ast) or alanine aminotransferase (alt) ≥3 times higher than the upper limit of the normal range, creatinine \>265umol/l (3mg/dl)) * the patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb. acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc. * pregnant or lactating women * he/she is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission * other conditions that the researchers think are not suitable for the group

Keywords: ric remote ischemic conditioning carotid artery occlusion hybird surgery interventional surgery
dexcom one: continuous glucose monitoring in the real world, utility of sustained high alerts

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to gather feedback on a new continuous glucose monitor (cgm), called dexcom one. unlike some other cgms which allow a low (hypoglycaemic) and a high (hyperglycaemic) glucose alarm to be set, the dexcom one sensor has the unique feature of the 'sustained hyperglycaemic alert', where the alarm is only activated if the glucose is above a certain threshold for a pre-specified amount of time. international consensus guidance states that people with diabetes should aim for 70% time in the range 3.9-10 mmol/l. after meals there is usually a rise in blood glucose, so it is not unexpected for the glucose to go above 10 mmol/l for a short time even if the insulin dose already given before a meal is correct. therefore, people with a high glucose alarm set at 10 mmol/l on their gcm may unnecessarily inject extra insulin and risk a low blood glucose. however, dexcom one's sustained hyperglycaemic alert would only notify patients if their blood sugar was high for a prolonged period, and so may reflect a time when it would be genuinely advantageous to inject more insulin. the aim of this single-centre, non-randomised, observational study is to gather experience from a range of users to assess the utility of this unique attribute, and the optimal settings. we aim to recruit 80-100 patients, and each participant's involvement is in 2 phases; for the first 3 months dexcom one sensors will be used, and for months 4-6 there will be the option of continuing to use the dexcom one sensors with the addition of a fitbit to track physical activity.


Eligibility criteria:
inclusion criteria: * aged 18+ years * a patient registered in the diabetes service at sheffield teaching hospitals nhs foundation trust * hba1c within the last 3 months of \>70 mmol/mol exclusion criteria: * unable to provide informed consent * unable to communicate in written and verbal english

Keywords: insulin-dependent