Kornimate/medical-research-clean huggingface dataset:
interest of emdr schizophrenic disorders

Conditions: Schizophrenic Disorders

Summary: the purpose of this study is to determine the interest of the use of emdr (eye movement desensitization and reprocessing) psychotherapy in the management of psychotic disorders, in particular schizophrenic disorders.

since 2015 more and more studies conducted by researchers, especially dutch and english, are interested in the use of emdr (eye movement desensitization and reprocessing) for other pathologies such as bipolar disorder, unipolar depression, anxiety disorders, psychotic disorders, substance use disorders and chronic pain. these studies show that emdr appears to be a technique that is both effective, capable of significantly improving symptoms, and without risk for patients, while respecting the protocol and the clinical stabilization provided during the procedure. to date, the use of emdr for the management of psychotic patients has not been the subject of any prospective study in france and the authors' conclusions converge on the fact that it is essential to carry out more research on the subject. for this, the investigators wish to evaluate the effect of emdr on the management of patients with schizophrenic disorders, on the basis that this psychotherapy would improve their quality of life (improvement of all the specific scores used in psychiatry). : panss, des, had and wemwbs scales). finally, the investigators believe that it is relevant to assess the benefit of emdr six months after hospitalization of patients, in order to measure the maintenance of this efficacy in the medium term

Eligibility criteria:
inclusion criteria: * ≥ 18 years and over, * hospitalized for decompensated psychotic disorder, positive diagnosis of schizophrenia or schizoaffective disorder (according to the dsm-v psychiatry manual), * with positive or negative symptoms according to the positive and negative syndrome scale (panss), * stabilized clinical condition (considered compatible with hospital discharge), * with ambulatory follow-up planned after hospitalization exclusion criteria: * \< 18 years, * patients who do not meet the diagnostic criteria (according to the dsm-v psychiatry manual) for schizophrenic or schizoaffective disorder), * non-french speaking or illiterate patients, * cognitive disorders making it impossible the understanding and the none- opposition to the study, * non-stabilized clinical condition (incompatible with hospital discharge),

Keywords: schizophrenic disorders psychosis eye movement desensitization and reprocessing
impact of echinacea as prophilaxis for upper respiratory tract infections in children 1-5 years

Conditions: Upper Respiratory Tract Infections

Summary: acute upper respiratory tract infections are the most commmon infections in children and are associated with complications such as acute otitis media, sinusitis and pneumonia. echinacea is widely used for treatment of upper respiratoty tract infections. the aim of this study is to evaluate its efficacy as prophilaxis in children 1-5 years old.


Eligibility criteria:
inclusion criteria: * childrens 1-5 years old exclusion criteria: * wheezing in previous 3 months requiring bronchodilatator * history of hyperactive reactive airway * using steroid or echinacea * chronic pulmonary of cardiac disease * acute respiratory disease within one week before study * allergic rhinitis * allergy to echinacea * avoiding to participate in the study

Keywords: upper respiratory tract infections echinacea viral infections
investigation of the optimal calcium supplement following roux-en-y gastric bypass

Conditions: Roux-en-Y Gastric Bypass; Hyperparathyroidism, Secondary

Summary: this study investigates whether calcium citrate or calcium carbonate are the optimal supplement to treat secondary hyperparathyroidism following roux-en-y gastric bypass operation. half of the participants will be randomized to receive calcium citrate, while the other half will receive calcium carbonate. the study will be double blinded.


Eligibility criteria:
inclusion criteria: * roux-en-y gastric bypass operation ≥12 months ago * parathyroid hormone \> 6.9 pmol/l * vitamin d \> 50 nmol/l * p-calcium \[1.18-1.32\] mmol/l exclusion criteria: * liver disease * renal disease * hypercalcemia * untreated thyroid disease * parathyroid disease except secondary hyperparathyroidism * use of diuretics, bisphosphonates, calcitonin, teriparatide, oral corticosteroids, anabolic steroids, calcimimetics, lithium, strontium, denosumab or anticonvulsants within 1 year of inclusion * abusing alcohol
paclitaxel in advanced refractory kaposi's sarcoma (aids-ks): a phase ii trial of paclitaxel from baker norton pharmaceuticals

Conditions: Sarcoma, Kaposi; HIV Infections

Summary: to determine response rate, median time to tumor progression, qualitative and quantitative toxicity and reversibility of toxicity in patients with advanced refractory aids-associated kaposi's sarcoma (ks) administered a 3-hour infusion of paclitaxel every 14 days. to evaluate the clinical benefit of paclitaxel in this patient population by evaluating self-reported responses to the symptom distress scale and by documenting and evaluating any changes in their lymphedema, pain and disfiguring facial lesions.

patients are treated with paclitaxel intravenously every 2 weeks up to 10 courses. patients who achieve a complete response receive 2 additional courses those who achieve partial response or stabilization, continue therapy until progression.

Eligibility criteria:
inclusion criteria patients must have: * microscopically confirmed diagnosis of ks associated with hiv for which systematic therapy is medically indicated by the presence of at least one of the following: a. \>= 25 mucocutaneous (mouth or skin) lesions. b. symptomatic visceral involvement. c. symptomatic lymphedema (pain). * minimum of 5 clearly measurably cutaneous lesions by physical exam or measurable disease by x-ray, ct or mri. * failed at least one systemic chemotherapy regimen. exclusion criteria co-existing condition: patients with the following conditions and symptoms are excluded: * less than 2 weeks since major surgery. * serious uncontrolled infection. note: * must be ruled out by thorough work-up in patients with unexplained fevers, night sweats, or involuntary weight loss of more than 10% normal weight. * leukopenia. * thrombocytopenia. patients with the following prior conditions are excluded: * history of angina or myocardial infarction within the past 6 months. * second degree or third degree atrioventricular block without a pacemaker. * congestive heart failure (poorly controlled). * history of prior malignancy except: completely excised in situ, carcinoma of the cervix or nonmelanomatous skin cancer. curatively treated other malignancy with no evidence of disease for at least 5 years. prior medication: excluded: prior taxane therapy. required: * at least one systemic chemotherapy regimen that failed to maintain significant benefit. note: * intralesional chemotherapy regimens are not considered as prior chemotherapy. * at least 2 weeks since last dose of prior systemic chemotherapy.

Keywords: sarcoma, kaposi acquired immunodeficiency syndrome paclitaxel treatment outcome antineoplastic agents, phytogenic
clinimetric properties of muscle mass and stiffness measurements of the quadriceps in patients with copd

Conditions: COPD; Quadriceps Muscle Atrophy

Summary: a large amount of patients with copd suffer from muscle dysfunction characterized by losses of muscle mass and strength. studies have shown an association between a loss of quadriceps muscle mass and premature death. this study aims to investigate the clinimetric properties of a simple quadriceps perimetry and shearwave elastography to improve the monitoring of skeletal muscle function in patients with copd.

muscle dysfunction in copd is characterized by reduced skeletal muscle mass and strength, particularly in the lower limbs. these systemic consequences of copd play a key role in the course of these patients, through their impact on functional status, quality of life and increased mortality. early detection and monitoring of muscular status in these patients could help improve management and limit the consequences of the disease. numerous studies show that variation in quadriceps mass has a significant relationship with premature mortality in this disease. the use of an indirect but simple and affordable measure: perimetric tape-measurement of thigh circumference, could help monitor quadriceps muscle mass in these patients on a regular and cost-effective basis. however, the clinimetric properties (validity, reliability, response to treatment) of this measurement need to be assessed to clarify its relevance. on the other hand, shearwave ® elastography (swe) is a new method of measuring quadriceps stiffness. this measurement could provide additional information on muscle quality compared with conventional measures of strength or muscle trophicity. the potential added value of swe ® for copd patients has not yet been investigated. this tool would provide more precise indications of the state of the quadriceps, with the aim of improving the management of this pathology.

Eligibility criteria:
inclusion criteria: * copd patients * adults (\>18 years old) * patients starting a pulmonary rehabilitation (pr) programme exclusion criteria: * patients included in other research protocol * minors or under guardianship * pregnancy * patients with lower limb amputation or history of neuromuscular disease * cardiovascular contradications for pr

Keywords: clinimetric properties muscle mass muscle strength
"fit for kids"-copenhagen

Conditions: Obesity

Summary: this study aims to evaluate the effect of a 40- week multifactorial intervention against overweight, obesity and physical inactivity in danish children. the investigators wish to examine 40 children before and after the "fit for kids" intervention with basic anthropometric measures such as body mass indexi (bmi), waist/hip ratio, systolic- and diastolic blood pressure, level of physical fitness and total body fat mass. furthermore the investigators wish to examine the more specific inflammatory, metabolic and hormonal effect of the intervention with a more extensive examination programme. the tests include a dxa-scan, cardio-respiratory fitness, accelerometer monitoring, pedometer monitoring, cognitive testing, continuous glucose monitoring system, different metabolic and inflammatory markers and an oral glucose tolerance test. the study will take place at centre of inflammation and metabolism, rigshospitalet, copenhagen. the study is a randomised controlled trial with a gradual rollout. the 40 children will be randomised. twenty children will start the intervention at baseline and 20 children will start after the first 20 weeks of intervention, thus providing a control group. the investigators expect to find a significant reduction in bmi, total body fat mass and systolic blood pressure after the intervention. as for the more extensive tests, the data approach is explorative, as the investigators look at more statistical dependent variables. the contribution of this project is a further description on the effect of intervention against overweight and physical inactivity on the metabolic and inflammatory response.


Eligibility criteria:
inclusion criteria: * obese children exclusion criteria: * other chronic medical conditions * medical intake

Keywords: obesity diabetes physical activity
a double-blind randomized placebo controlled clinical trial evaluating effect of chlorhexidine gluconate 2% cloth vs placebo cloth baths on the incidence of central line-associated blood stream infections in outpatient hematopoietic stem cell transplant patients

Conditions: Stem Cell Transplant Complications

Summary: this study evaluates the use of 2% chg washcloths in an outpatient setting for adults after hematopoietic stem cell transplant in prevention of central line associated blood stream infections. half of the participants will use 2% chg washcloths and other half will use placebo washcloths.


Eligibility criteria:
inclusion criteria: * admitted to the university of chicago hematopoietic stem cell transplant unit for transplant * age 18 and up exclusion criteria: * experienced an allergy or rash related to use of chlorhexidine washcloths or other chlorhexidine products * extensive open wounds
the use of etonogestrel contraceptive implant as treatment for endometrial hyperplasia without atypia: a cohort study

Conditions: Endometrial Hyperplasia Without Atypia

Summary: endometrial hyperplasia without atypia is a condition in which the endometrium (the lining of the uterus) becomes abnormally thick. although endometrial hyperplasia without atypia is not cancer, it can lead to endometrial cancer in 1-3% of women. this disease is treated by giving progestins. the optimal route, dosage and duration of progestin treatment for endometrial hyperplasia has not yet been determined until now. however, several publications have suggested the use of levonorgestrel releasing iud as first-line treatment for endometrial hyperplasia without atypia. the other common medications used are the oral progestins medroxyprogesterone (mpa) and norethisterone acetate (neta). the etonogestrel implant (implant nxt) has been approved for contraceptive use by the us fda in 2006. the mchanism of action of the implant for contraception suggests a potential application for its use in the treatment on hyperplasia. off-label use of the implant for adrnomyosis, endometriosis and chronic pelvic pain has already been described in various studies. however, its therapeutic effect on endometrial hyperplasia without atypia has not been studied yet. the researchers propose to use the etonogestrel implant (implant nxt) as novel treatment for endometrial hyperplasia without atypia. the study aims to determine the rate of regression to normal endometrium among patients with endometrial hyperplasia without atypia at 3 and 6 months after insertion of the implant.


Eligibility criteria:
inclusion criteria: * women aged 18 years old to perimenopause who present with or without abnormal uterine bleeding and who have an endometrial biopsy result which shows endometrial hyperplasia without atypia * women willing to have the etonogestrel implant (implant nxt) for the duration of treatment (6-12 months) * women who wish to retain their uterus exclusion criteria: -

Keywords: endometrial hyperplasia without atypia etonogestrel implant
insulin-based strategies to prevent hypoglycemia during exercise

Conditions: Type 1 Diabetes Mellitus

Summary: it has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise. however, another potentially more efficient strategy to prevent exercise-induced hypoglycemia could be to reduce insulin basal rate a certain time prior to exercise. the objective of this study will be to compare the efficacy of two strategies to prevent exercise-induced hypoglycemia during a 60-minute exercise at moderate intensity: 1) reduce insulin basal rate 40 minutes prior to exercise; 2) reduce insulin basal rate 90 minutes prior to exercise.


Eligibility criteria:
inclusion criteria: 1. males and females ≥ 14 years of old. 2. clinical diagnosis of type 1 diabetes for at least two years. 3. the subject will have been on insulin pump therapy for at least 3 months. 4. last (less than 2 months) hba1c ≤ 10%. exclusion criteria: 1. clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate below 40 ml/min), neuropathy or severe proliferative retinopathy as judged by the investigator. 2. recent (\< 3 months) acute macrovascular event e.g. acute coronary syndrome or cardiac surgery. 3. abnormal blood panel and/or anemia. 4. ongoing pregnancy. 5. severe hypoglycemic episode within two weeks of screening. 6. other serious medical illness likely to interfere with study participation or with the ability to complete the exercise periods by the judgment of the investigator (e.g. orthopedic limitation). 7. failure to comply with team's recommendations (e.g. not willing to change pump parameters, etc.).

Keywords: type 1 diabetes exercise hypoglycemia insulin pump
outpatient psychotherapeutic treatment for alcohol dependent individuals with comorbid psychiatric disorders

Conditions: Alcohol Dependence

Summary: research has shown that alcohol dependence often co-occurs with comorbid anxiety disorders and/or depression. anxiety and depression influence the course and treatment of alcohol dependence and are a major risk factor for alcohol relapse within the first three months after detoxification. therefore, there is need for combined treatment (integrated therapy) of alcohol dependence and comorbid psychiatric disorders, e.g. anxiety and/or depression. until today, there are no systematic outpatient treatment offers for this special group of patients in germany. in this study we want to investigate if integrated outpatient cognitive behavioral therapy can prevent and decrease alcohol relapse within the first three months after detoxification. therefore we hypothesize that immediate start of integrated outpatient psychotherapy will reduce relapse variables compared to treatment as usual which is characterized by non-immediate start of therapy due to the required application for insurance coverage.


Eligibility criteria:
inclusion criteria: * alcohol dependence * comorbid anxiety or mood disorder exclusion criteria: * severe mental illness: psychosis, mania, personality disorders * current suicidality * non-compliance with appointments during first 5 sessions
swiss childhood health and nutrition survey

Conditions: Overweight and Obesity in Schoolchildren

Summary: the aim of the present study is to assess the prevalence of overweight and obesity in 6 to 12 year old children in switzerland. this data will be used to investigate trends in the development of overweight and obesity in switzerland. in addition, a questionnaire will be used to assess data on physical activity, nutrition, health and socioeconomic background and waist circumference as well as skin fold thicknesses will be measured.


Eligibility criteria:
inclusion criteria: * age between 6 and 12 years exclusion criteria: * none
characterization of bacterial and mycosis skin flora in seborrheic macular hypopigmentation - microbiome

Conditions: Hypopigmentation

Summary: hypopigmented skin changes are commonly encountered by dermatologists. a new dermatological entity was identified as scattered, hypopigmented oval-shaped macules and patches distributed mostly in seborrheic area of the face and of the trunk in dark skinned individuals. this patterned presentation of hypopigmentation was first described in the literature under the name of hypochromic vitiligo or vitiligo minor. nerveless, histopathological patient's specimens analyzed by krueger et al. clearly highlight that there is no tangible causal correlation with a diagnosis of vitiligo. they propose to rename this entity to seborrheic macular hypopigmentation (smh). the etiopathology of this dermatosis is still unknown preventing to propose any satisfactory treatment for this disfiguring affection.the objective of this study is to analyze the bacterial and fungal skin microbiome on hypochromic lesions of smh compared to the surrounding non-lesional skin of the same patients and to healthy volunteers


Eligibility criteria:
inclusion criteria: 1. female and male patients ≥ 18 years of age 2. clinical diagnosis of smh with lesion of the face 3. written informed consent obtained before any assessment is performed 4. affiliation with a social security scheme 5. physical and psychological ability to participate exclusion criteria: 1. use of systemic antibiotics or any systemic antifungal treatments within 4 weeks before the inclusion visit 2. use of topical antibiotics or any topical antifungal treatments on the face within 2 weeks before the inclusion visit 3. use of any topical cream, gel, serum or ointment within 2 days before the inclusion visit 4. laser, radiofrequency, peeling or any other procedure on the face in the past 3 months before the inclusion visit 5. vulnerable patients: minors, patients under guardianship or curatorship, pregnant or breast-feeding women
traditional acupuncture and myofascial trigger point dry needling and acupressure for chronic low back pain

Conditions: Low Back Pain

Summary: the purpose of this study is to compare the therapeutic effects of acupuncture using traditional acupoints and ashi points with myofascial trigger points superficial dry needling and acupressure, followed by postisometric stretching of the appropriate muscles, in the treatment of patients with chronic mechanical low back pain.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mechanical lower back pain for at least three months. * the chronic mechanical lower back pain is the chief complaint, with or without leg pain. * the lower back pain is disabling to the degree that affects the patient's routine job and/or his or her lifestyle. exclusion criteria: * patients with tumor, infection, major trauma to the spine causing fracture or disruption of the major ligaments, or cauda equina syndrome. * patients with neurological signs of spinal nerve compression. * patients having undergone spinal surgery, facet joint block and/or corticoid injection. * patients with general contraindications for acupuncture or acupressure treatment.

Keywords: low back pain, chronic acupuncture dry needling acupressure acupuncture points trigger points, myofascial
hobscotch for people with post acute covid-19 syndrome (pacs)

Conditions: Post Acute COVID 19 Syndrome; Memory Impairment; Memory Dysfunction; Cognitive Dysfunction

Summary: the goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, hobscotch, for people with post acute covid syndrome (pacs). the main questions it aims to answer are: can the current hobscotch program be adapted for people with pacs? will people with pacs experience improved quality of life similar to that found in people with epilepsy after participating in the hobscotch program? participants will be asked to: * attend nine, one-hour virtual (online and/or by telephone) hobscotch-pacs sessions with a one-on-one certified hobscotch-pacs coach * complete a brief clinical questionnaire about their diagnosis of pacs * complete seven questionnaires before and after the hobscotch-pacs sessions about their quality of life, memory and thinking processes (objective and subjective cognition), about their physical and mental health and about autonomic symptoms associated with their diagnosis of pacs * keep a short daily diary (using a smart phone app or on paper) about their pacs symptoms and use of the self-management strategies taught in the hobscotch-pacs program * complete two brief surveys to assess satisfaction with their experience after the entire hobscotch-pacs program


Eligibility criteria:
inclusion criteria: * literate, english-speaking with grade 12 or equivalent in education * self-reported diagnosis of pacs * self-reported cognitive/memory difficulties * telephone and internet access exclusion criteria: * cognitive dysfunction that precludes participation in giving informed consent * significant visual impairment precluding reading or writing * no reliable telephone or internet access * neurodegenerative illness (i.e. dementia) * acute psychiatric disease

Keywords: post acute covid 19 syndrome long covid memory cognitive training self-management