Kornimate/medical-research-clean huggingface dataset:
understanding the increased risk of atrial fibrillation in athletes: a case-control study

Conditions: Atrial Fibrillation (AF)

Summary: exercise is beneficial to heart health, however, there appears to be a 'u' shaped relationship where too much exercise may increase the risk of an irregular heart rhythm, called atrial fibrillation. endurance athletes may have up to a 2.5-fold higher risk of developing atrial fibrillation than non-athletic controls. the mechanisms behind this increased risk of atrial fibrillation are not the well understood. it is thought to be a mixture of enlarged heart chambers, low resting heart rate, genetic predisposition and possibly scarring in the heart. in this study, the investigators will investigate the electrical activity changes in the heart, using a high-quality electrocardiogram (ecg) and relate this to changes in the heart size measured by ultrasound and mri. cardiopulmonary exercise testing will determine fitness (v̇o2 max) and assess the heart's electrical activity during exercise. this will be a case-control study where athletes with and without atrial fibrillation will be recruited. the investigators hope the results of this study can improve our understanding of atrial fibrillation in athletes by associating atrial fibrillation with structural and electrical differences which may aid the prediction of future atrial fibrillation development and help guide more athlete-specific treatment pathways.


Eligibility criteria:
inclusion criteria: * ≥18 years of age at the time of enrolment, male and female. * history of atrial fibrillation confirmed on ecg - either paroxysmal or persistent. * competitive athlete. defined as: 1. competed in endurance sports with a total cumulative moderate to high intensity of \> 1500 hours. 2. have participated in at least one competitive event in the last 10 years. exclusion criteria: * permanent atrial fibrillation. * history of pre-existing cardiovascular disease : 1. atherosclerotic disease: previous myocardial infarction, symptomatic coronary artery disease or peripheral peripheral arterial disease 2. left ventricular systolic dysfunction (ef \< 45%) 3. heart muscle disease: cardiomyopathies, infiltrative diseases of the heart 4. complex congenital heart disease 5. moderate or severe valvular disease 6. uncontrolled hypertension (\>180/100mmhg)

Keywords: atrial fibrillation athletes sport physical activity exercise arrhythmias
problematic use and addiction in primary care

Conditions: Addiction Disorders; Primary Care

Summary: the morbi-mortality and social cost of addictive disorders led the french authorities to set up a government plan in 2018 to combat drugs and addictive behavior (interministerial mission to combat drugs and addictive behaviour - (mildeca)). in particular, it encourages early detection, which is the first stage in a validated global approach to the management of addictive disorders. improving early identification of addictive disorders in primary care would reduce morbidity and mortality and improve quality of life for patients with addictive disorders. the identification of use disorders should be systematic in primary care and was the subject of a recommendation in 2015. numerous tests are cited in these recommendations, but few have actually been validated in primary care, and none has been shown to be feasible. for example, only 23% of gps claim to systematically identify alcohol consumption. other primary care professionals (physiotherapists, nurses, midwives, dentists, pharmacists) also have a role to play in identifying addictive disorders. the evolution of their respective professions (delegation of tasks, creation of the profession of advanced practice nurse, medical assistants) and the recent reorganization of the practice framework, both in terms of practice structures and professional community organizations, involve them in a global multidisciplinary collaboration on patient care, particularly in the early identification of addictive disorders. the hypothesis is that the difficulties in implementing tests to identify addictive disorders in primary care are linked to the lack of specific consideration of the needs of primary care patients and caregivers. the overall aim of the study is to improve the early detection of addictive disorders through brief training for primary care healthcare professionals.

the project comprises three successive stages: 1. design a training program with content tailored to primary care professionals; 2. evaluate the feasibility and acceptability of the training; 3. evaluate the implementation of this training program by comparing the incidence of addiction disorder detection by primary care professionals between a trained and an untrained group.

Eligibility criteria:
inclusion criteria: * be a primary care professional (physiotherapists, nurses, midwives, dentists, pharmacists, general practitioner) * in ambulatory practice. recruitment will be carried out with the help of territorial professional health communities, to include practitioners practicing in conditions representative of the diversity of primary care practice. gps agreeing to take part will be divided into a control group and an intervention group, by drawing lots. exclusion criteria: * refusal to participate. * the same participant may not be included in more than one stage.

Keywords: short training program
intracranial atherosclerosis and depression after coronary artery bypass graft

Conditions: Depression; Intracranial Atherosclerosis; Coronary Artery Disease

Summary: the purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery. the main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-cabg depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.


Eligibility criteria:
inclusion criteria: * age: 40 years or older * will be having cabg surgery at the yale new haven hospital * be able to provide informed consent * have a household telephone * a fluent english speaker, and possessing no communication barrier * be able to come to the study site or to have the study team come to his/her home. * has a family member or partner/ friend who could provide collateral information exclusion criteria: * has had previous cabg surgery * history of dementia diagnosis or cognitive impairment (cdr \>/= 1) * auditory or visual impairment that would interfere with study procedures * active alcohol or substance abuse problem based cage-aid (endorsing two or more items) * history of bipolar disorder, schizophrenia, schizoaffective disorder, or any psychotic disorder by medical history or self-report. * presence of non-cardiovascular conditions likely to be fatal within 1 year

Keywords: depression vascular depression intracranial atherosclerosis coronary artery disease coronary artery bypass graft cognitive impairment
nis to observe improvement in global assessment of functioning in patients with schizophrenia

Conditions: Schizophrenia

Summary: the purpose of the study is to monitor the general functional changes among patients with schizophrenia, treated with atypical antipsychotics dosed once daily for a period of 6 months.the primary study objective is to compare general functioning of patients with schizophrenia treated with seroquel sr between baseline and the last study visit. the secondary study objectives are to compare general functioning of patients with schizophrenia treated with other atypical antipsychotic medicinal products administered once daily between baseline and the last study visit, monitoring of other indicators of clinical improvement, evaluation of patient compliance and assessment of occurrence of adverse effects


Eligibility criteria:
inclusion criteria: * patients have a diagnosis of schizophrenia, as defined by dsm-iv-tr * patients' symptoms are controlled with seroquel sr started up to 1 month before the inclusion * or patients' symptoms are controlled with other atypical antipsychotic in once daily formulation started up to 1 month before the inclusion exclusion criteria: * patients who are treated with seroquel sr or other antipsychotic more than 1 month * patients with prescribed antipsychotic combinations * pregnant women or women who are breast-feeding * patients who have been treated with antipsychotics in depot formulations for the last two months

Keywords: schizophrenia seroquel sr atypical antipsychotics assessment of functioning gaf scale
efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in patients with psoriasis vulgaris

Conditions: Psoriasis Vulgaris

Summary: this study will evaluate the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment compared with calcipotriol ointment in the treatment of patients with psoriasis vulgaris for a duration of 4 weeks. the study will focus on the percentage change of the psoriasis area and severity index (pasi) from baseline to the end of week 4.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of psoriasis vulgaris in a stable condition * extent of at least 10% of one or more body regions * amenable to topical therapy with maximum of 100 g/week of investigational product exclusion criteria: * patients with more than 30% of body surface area involved * patients with facial psoriasis who need treatment * patients who need treatment of scalp psoriasis with who group iv topical corticosteroids, tretinoin or topical vitamin d derivatives * patients with unstable forms of psoriasis including guttate, erythrodermic, pustular, or arthritis psoriasis * systemic treatment of psoriasis with corticosteroids or other therapy * systemic antipsoriatic treatment (e.g. corticosteroids, immunosuppressive drugs, tretinoin, antibiotics, phototherapy or calcium agents) within 4 weeks prior to visit 1; or topical antipsoriatic treatment (e.g. keratolytics, topical corticosteroids, topical vitamin d derivatives, anthralin, crude coal tar, etc) within the previous 2 week period * patients with planned exposure to phototherapy that may affect the psoriasis during the study period
effects of a complex cognitive training in mild cognitive impairment and mild alzheimer's disease

Conditions: Alzheimer's Disease; Cognitive Impairment

Summary: a recent meta-analysis that included over 29.000 individuals found that the odds ratio (or) of individuals with high brain reserve compared to low was 0.54 (p \< 0.0001), a risk decrease of 46%. among the factors that influence cognitive reserve, mentally stimulating activities was the most robust factor after controlling for education, age, occupation and other potential confounds. the brain reserve effect was sustained over a median longitudinal follow-up of 7 years. it would be interesting to detect whether a complex cognitive training could show similar effects on the cognitive abilities of patients with mild alzheimer's disease (ad) and mild cognitive impairment (mci) as it has been reported in previous studies based on mentally stimulating activities analysis. the hypothesis is that a complex cognitive training alters the neural networks in both subject groups and this alteration is associated with improvement or stabilization of cognitive and non-cognitive function. the investigator will perform a complex cognitive training program. twenty patients with mild ad and twenty four patients with mci will be recruited in this study. the patients will be randomised in control- and treatment groups.additionally indirect effects on non-cognitive functions will be evaluated in caregivers of the patients. the investigators expect that the cognitive and non-cognitive abilities will be changed during the cognitive training. the investigators also expect differences between treatment and control groups.


Eligibility criteria:
inclusion criteria: * male or female patients aged ≥ 55 years, fulfilling criteria of the national institute of neurological and communicative disease and stroke (nincds) and the alzheimer's disease and related disorders association (adrda) for the diagnosis of clinically probable ad or petersen's criteria of mild cognitive impairment (mci) * no evidence for other psychiatric axis i disorders according to dsm-iv criteria * no uncontrolled arterial hypertension or diabetes mellitus * no history of drug/alcohol abuse * cholinesterase inhibitors or memantine must have been in a stabile doses at least 2 moths in ad subject group prior to the baseline * the patient is able to provide written informed consent to participate in the study. if, at investigator's discretion, a patient is considered not to be capable to give legal consent, then written consent must also be obtained from the patient's legally acceptable representative. exclusion criteria: * evidence for other psychiatric axis i disorders according to dsm-iv criteria * uncontrolled arterial hypertension or diabetes mellitus * history of drug/alcohol abuse * no ability to participate and no willing to give informed consent and comply with the study restrictions

Keywords: mild alzheimer's disease mild cognitive impairment
parental feelings about their child needing a central line

Conditions: Critical Illness; Children, Only; Stress

Summary: the goal of this research project is to determine if different communication techniques during the consent process impact parental anxiety and comfort providing consent.

the parents of children in the pediatric intensive care units (picus) at columbia university may be asked if they are interested in participating in this study if their child needs a central venous line (cvl) or peripherally inserted central catheter (picc) placed. if the parents are interested in participating, they will be randomly assigned to a communication technique group while they are discussing the procedure and giving consent with a medical team member. after they provide consent, they will be asked to complete surveys about their thoughts and feelings. the study should take about 15 minutes. after data is collected, the researchers will compare survey answers between the two communication styles used with parents.

Eligibility criteria:
inclusion criteria: * parent or guardian of a child admitted to the pediatric intensive care units (picus) at columbia university * the child needs a central venous line (cvl) or peripherally inserted central catheter (picc) placed in the picu * the parent or guardian speaks english or spanish exclusion criteria: * parents or guardians who speak languages other than english or spanish * parents or guardians of children who need a cvl or picc placed during an emergency without consent * parents or guardians who are unable to be physically present and provide consent over the phone

Keywords: central venous line (cvl) peripherally inserted central catheter (picc)
efficacy of tinoridine in treating pain and inflammation in adults

Conditions: Pain; Inflammation

Summary: the purpose of this study is to confirm the efficacy of tinoridine hydrochloride (hcl), three times daily (tid), in the treatment of pain and inflammation in patients with acute tonsillitis and/or acute pharyngitis of nonbacterial origin versus placebo.

tonsillitis and pharyngitis are the most common upper respiratory tract infections. the signs and symptoms are sore throat, difficulty with swallowing and/or inflamed tonsils and/or pharynx. in most cases these infections are viral in origin. tinoridine is a nonsteroid anti-inflammatory drug with a different mechanism of action than common nonsteroidal anti-inflammatory drugs (nsaids), which act by inhibiting the cyclooxygenase enzyme and thereby inhibit the synthesis of prostaglandins. the purpose of this study is to confirm the efficacy of tinoridine in the treatment of pain and inflammation in patients with acute tonsillitis and/or acute pharyngitis of nonbacterial origin versus placebo.

Eligibility criteria:
inclusion criteria: * participants with the following signs \& symptoms: sore throat, difficulty with swallowing, and inflamed of pharynx and/or tonsils. * onset within 2 days exclusion criteria: * pregnant or lactating women * participants hypersensitive to tinoridine * participants with fever, peptic ulcer, serious blood abnormality, serious hepatic impairment, serious kidney impairment * participants with aspirin-induced asthma * drug or alcohol abuse * participants receiving analgesic antiinflammatory drug, antibiotic and/or antiviral within 2 days before entering this study

Keywords: tonsillitis pharyngitis sore throat drug therapy
safety and efficacy study of onglyza (saxagliptin) under conditions of actual use

Conditions: Type 2 Diabetes Mellitus

Summary: this post marketing surveillance study aims to monitor the safety and efficacy of onglyza under conditions of actual use in patients who are diagnosed with diabetes mellitus type 2 and are prescribed onglyza by their physician.


Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes mellitus * prescribed saxagliptin by patient's attending physician exclusion criteria: * known allergic or serious adverse reaction to saxagliptin * pregnant or breastfeeding patients

Keywords: saxagliptin type 2 diabetes clinical practice
investigating the role of the polyol pathway in the central nervous system

Conditions: Hyperglycemia

Summary: patients will undergo magnetic resonance spectroscopy (mrs) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.


Eligibility criteria:
inclusion criteria: * type 2 dm with hba1c treated with metformin, sulfonylurea, insulin, or combination or age-matched, non-diabetic obese (bmi \> 30 kg/m\^2) or age-matched lean, healthy control subjects (bmi \< 25 kg/m\^2) * age 18-55 * bmi 18-45 kg/m\^2 exclusion criteria: * creatinine \> 1.5 mg/dl * hgb \< 10 mg/dl * alt \> 2.5 x uln * untreated thyroid disease * uncontrolled hypertension * known neurological disorders * untreated psychiatric disorders * malignancy * bleeding disorders * smoking * current or recent steroid use in last 3 months * illicit drug use * pregnancy, actively seeking pregnancy, or breastfeeding * inability to enter mri/mrs
a study of ly900014 administered in participants with type 1 diabetes using an insulin pump

Conditions: Diabetes Mellitus, Type 1

Summary: this study will be conducted in participants with type 1 diabetes mellitus to investigate how the human body processes ly900014, a new blood sugar lowering insulin, and its effect on blood sugar levels when it is delivered via an insulin pump. side effects and tolerability will be documented. the study will last about 4 to 11 weeks for each participant.


Eligibility criteria:
inclusion criteria: * male or female participants with type 1 diabetes mellitus (t1dm) who are receiving insulin therapy via an approved insulin pump * have a screening body mass index (bmi) of greater than 18.5 to 33.0 kilograms per meter squared (kg/m²), inclusive * have medical and laboratory test results that are acceptable for the study * have had no episodes of severe hypoglycemia (requiring assistance in treatment by a second party) in the past 6 months * have venous access sufficient to allow for blood sampling * have provided written consent and are willing to follow study procedures and commit to the study duration exclusion criteria: * are currently participating or recently participated in a clinical trial or any other type of medical research judged to be incompatible with this study * had blood loss of more than 500 milliliters (ml) within the last month * have known allergies to ly900014, insulin lispro, related compounds or any components in the study drug formulations * have previously participated or withdrawn from this study * have or used to have health problems or medical test results that, in the opinion of the doctor, could make it unsafe to participate, or could interfere with understanding the results of the study
comparison of emergence agitation between sevoflurane and desflurane anesthesia after orthognathic surgery

Conditions: Emergence Agitation

Summary: emergence agitation is a major concern in patients undergoing orthognathic surgery. the patients may experience the sense of suffocation during emergence due to nasotracheal intubation and orofacial edema. postoperative pain is also associated with emergence agitation. although there is a lot of studies about emergence agitation in children, there is a few in adults, furthermore, no data about comparison of emergence agitation between sevoflurane and desflurane anesthesia in adults. therefore, the investigators would like to compare the incidence and severity of emergence agitation between sevoflurane and desflurane anesthesia in adults after orthognathic surgery.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists(asa) physical status classification 1 or 2 patients * patients scheduled for orthognathic surgery exclusion criteria: * severe cardiopulmonary disease * psychological disease * patients who cannot understand korean
relationship between the functional movement screen and isokinetic muscle strength of knee in different sport branches

Conditions: Muscle Strength; Sport Injury; Muscle Contraction

Summary: this study was conducted to demonstrate the correlation between the functional movement screen and the isokinetic muscle strength with objective data. investigators conclude that the use of fms in combination with isokinetic systems will provide more detailed information on the prevention of injuries to sports and the improvement of performance.

this study was conducted to demonstrate the correlation between the functional movement screen and the isokinetic muscle strength with objective data. 60 athletes involved in volleyball, greco-roman, speed skating, athletics and taekwondo branches were included in the study. the functional movement of the athletes was assessed by functional movement screening, lower extremity isokinetic muscle strength was assessed by isomed 2000® isokinetic device.

Eligibility criteria:
inclusion criteria: * those who voluntarily agreed to participate in the study * have at least 3 years of licensed sports experience exclusion criteria: * those who have had or have ongoing orthopedic problems in the last 6 months

Keywords: functional movement screen h/q ratio isokinetic systems muscle strength
a pharmacokinetics and safety study of naproxcinod in subjects with impaired renal function

Conditions: Renal Failure

Summary: to study the pharmacokinetics and safety of naproxcinod in patients with impaired renal function

this is an 8-day, repeated dose, open label study to investigate the pharmacokinetics and safety of naproxcinod in order to guide initial dosing and achieve the optimal dose of naproxcinod in renal impaired patients.

Eligibility criteria:
inclusion criteria: * male or female aged 18 to 75 years with stable mild to moderate renal insufficiency. * male or female aged 18 to 75 years with similar distribution of age, weight, gender, smoking habits, and race, and in general good health exclusion criteria: * any significant acute or chronic disease (except renal impairment) which may interfere with study evaluations. * a history of alcohol or drug abuse. * diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding within the last 6 months * clinically relevant abnormal ecg * current or expected use of anticoagulants or analgesic, anti-inflammatory therapies except low dose aspirin (less than or equal to 325mg per day). * participation within 30 days prior to screening in another investigational study.