Kornimate/medical-research-clean huggingface dataset:
interactionality of music preference and individual variables in pain perception and management

Conditions: Cancer

Summary: the purposes of this study were 1) to delineate any differences in general musical taste (trait) and context-specific music preference (state), as well as preferred music characteristics in cancer patients, 2) to investigate the contributions of individual variabilities, personality, behavioral coping styles, and pain levels in predicting changes from trait to state preferences and preferred music characteristics under various pain conditions. cancer patients were recruited to fill in questionnaires pertaining to their demographic information (age, gender, religious preference, ethnicity, music background and experience), personality traits, music preferences, preferences for music characteristics, coping styles, and pain experiences.


Eligibility criteria:
inclusion criteria: 1. stage iv cancer diagnosis 2. between 40 - 70 years old 3. normal or corrected hearing 4. able to communicate (speak, comprehend, read, write) in english 5. signed informed consent form exclusion criteria: 1. under 40 or over 70 years old 2. not able to communicate in english 3. uncorrected hearing loss/impairment 4. dementia, psychosis (hallucinations, delusions) that interferes with cognitive processing (verbal and music)
oral antibiotic treatment of helicobacter pylori reduces intestinal colonization rates with oxalobacter formigenes

Conditions: Nephrolithiasis

Summary: the investigators are finding out if giving antibiotics for helicobacter pylori will eliminate colonization of the colon by oxalobacter formigenes.

background and objectives: oxalobacter formigenes (of) may play a protective role in preventing calcium oxalate stones. intestinal colonization by of is associated with reduced urinary oxalate excretion. exposure to antibiotics may be an important factor contributing to variable rates of colonization. this is the first prospective study to evaluate the effect of antibiotics on of colonization. design, setting, participants, \& measurements: the effect of antibiotics on of colonization was compared in 2 groups: a group receiving antibiotics for gastric infection with helicobacter pylori (hp) and a group without hp that not receiving antibiotics. of colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.

Eligibility criteria:
inclusion criteria: * age 18-80 years old * undergoing upper endoscopy * h. pylori present or absent on gastric histology * stool positive for oxalobacter formigenes exclusion criteria: * unable to consent * stool negative for oxalobacter formigenes

Keywords: nephrolithiasis urolithiasis hyperoxaluria helicobacter pylori
accuracy of vabb elite 10g versus bard 14g cnb

Conditions: Breast Cancer

Summary: in this study, patients whose breast ultrasound showed a space-occupying lesion and needed biopsy to clarify the pathology were selected as the research subjects. this study aims to determine whether vacuum-assisted biopsy device elite is superior to the traditional bard ejection type air core needle in the diagnosis of breast cancer through a prospective randomized study.

the main purpose of the study was to analyze the difference in the accuracy of two biopsy devices in the diagnosis of breast cancer puncture. the purpose of the secondary study was to analyze the difference between the underestimation rate, false negative rate, sensitivity, and negative predictive value of the two devices, the consistency of the immunohistochemistry between the puncture pathology and surgical pathology of the two groups of patients, the number and time-consuming of the puncture acquisition specimens, and the two biopsies differences in the incidence of complications (safety). if the biopsy device is a vacuum-assisted elite 10g needle, insert the needle groove into the mass and rotate to cut the biopsy tissue one circle; if the biopsy device is a bard 14g hollow core needle, insert the needle to the edge of the mass and pull the trigger in different directions to eject the needle to retrieve the material.

Eligibility criteria:
inclusion criteria: * over 18 years old (including 18 years old) * ultrasound examination indicates the presence of space-occupying lesions in the breast. the size, location, and bi-rads classification are not limited. * agree to undergo surgery after puncture * ability and willingness to sign informed consent exclusion criteria: * a biopsy has been performed in the external hospital * contraindications for puncture or surgery such as severe coagulation dysfunction * refuse breast surgery * axillary lymph node puncture
efficacy and safety of dalbavancin for the treatment of acute bacterial skin and skin structure infections

Conditions: Abscess; Wound Infection; Surgical Site Infection; Cellulitis

Summary: the primary object is to compare the early clinical efficacy (after 48-72 hours of therapy) of dalbavancin to the comparator regimen (vancomycin with the option to switch to oral linezolid) for the treatment of patients with a suspected or proved gram-positive bacterial skin or skin structure infections.


Eligibility criteria:
inclusion criteria: 1. male or female patients 18 - 85 years of age. 2. signed and dated informed consent document. 3. major abscess, surgical site infection, traumatic wound infection or cellulitis suspected or confirmed to be caused by gram-positive bacteria. 4. at least two (2) local signs and symptoms of absssi and at least one (1) systemic sign of infection. 5. requires a minimum of 3 days of iv therapy. 6. patient willing and able to comply with study procedures. exclusion criteria: patients presenting with any of the following: 1. a contra-indication to any required study drug. 2. pregnant or nursing females. 3. sustained shock. 4. participation in another study of an investigational drug or device within 30 days. 5. receipt of a systemically or topically administered antibiotic within 14 days prior to randomization, except receipt of a single dose of a short-acting antibacterial drug 3 or more days prior to randomization. 6. infection due to a dalbavancin or vancomycin-resistant organism. 7. evidence of meningitis, necrotizing fasciitis, gas gangrene, gangrene, septic arthritis, osteomyelitis, and/or endovascular infection. 8. exclusively gram-negative bacterial or a fungal absssi. 9. venous catheter infection. 10. infection of a diabetic foot ulcer or a decubitus ulcer. 11. device-related infections. 12. gram-negative bacteremia. 13. infected burns. 14. infected limb with critical ischemia. 15. superficial/simple skin and skin structure infections. 16. concomitant condition requiring non-study antibacterial therapy. 17. absssi requiring therapy for longer than 14 days. 18. adjunctive therapy with hyperbaric oxygen. 19. more than 2 surgical interventions for absssi anticipated. 20. chronic inflammatory condition precluding assessment of clinical response. 21. absolute neutrophil count \< 500 cells/mm3. 22. human immunodeficiency virus (hiv) infection with a cd4 cell count \< 200 cells/mm3. 23. recent bone marrow transplant, \> 20 mg prednisolone per day (or equivalent) or receiving immunosuppressant drugs after organ transplantation. 24. regular, chronic antipyretic use in patients unable to modify during the first three days of study drug therapy. 25. life expectancy less than 3 months. 26. conditions that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results. 27. prior participation in the study.
validation of a food addiction screening test

Conditions: Food Addiction; Obesity

Summary: food addiction (fa) is a behavioral addiction characterized by a high consumption of palatable foods, which markedly activate the reward system, despite adverse consequences. fa was first described in 1956 but remains controversial. the yale food addiction scale (yfas), developed by gearhardt et al. in 2009, is currently regarded as the "gold standard" for fa screening. in a previous study, we established a food addiction screening test using artificial intelligence. the main objective of the present study is to validate the sensitivity, specificity and precision for fa diagnosis in a sample of patient suffering from obesity and healthy volunteers.


Eligibility criteria:
inclusion criteria: * bmi ≥ 30 * able to consent exclusion criteria: * non-french speaker * patient unable to use internet tools

Keywords: food addiction obesity
urodynamics and clinical factors that are associated with bladder over-sensitivity

Conditions: Overactive Bladder Syndrome; Bladder Outlet Obstruction; Benign Prostate Enlargement; Stress Incontinence (Female) (Male); Bladder Disease

Summary: urodynamic examination evaluates storage and empting phases of the urinary bladder. it enables the clinician to correlate physiologic findings to patients' complains. the data gathered during the examination divided to storage and empting. during the storage phase, bladder sensation is measured while the bladder is filled with sterile water. during years of practice, we noticed that early sensation (bladder over-sensitivity) is occasionally associated with bladder outlet obstruction (as demonstrated in the emptying phase of the examination.

the study includes patients who were referred to urodynamics examination due to lower urinary tract symptoms. there is no actual intervention during the examination. though, patients are asked to fill an international prostate symptom score (ipss-questionnaires).

Eligibility criteria:
inclusion criteria: * all patients refered to asaf harofeh medical center for urodynamic examination exclusion criteria: * inability to sign an informed concent * administration of analgesics 8 hours prior to the examination * known urethral stricture * chronic bladder or urethral pain * active cystitis * permanent urinary catheter

Keywords: urodynamics bladder sensation confounding factors
assessment of impact of inspiratory muscle training on movement fear due to dyspnea in chronic obstructive pulmonary disease

Conditions: COPD

Summary: in our study, it was aimed to evaluate the effect of inspiratory muscle training on fear of movement due to dyspnea in copd patients. participants will be randomly assigned to two groups. inspiratory muscle training in the training group will be administered at least 5 days a week, 15 minutes twice a day, beginning at 30% of the mip for 8 weeks. patients will come to the control once a week, the mip values will be re-measured and the new training intensity will be determined at 30% of the new value. for the control group, a fixed training session will be given for at least 5 days a week, 15 minutes twice a day, not exceeding 15% of the mip for 8 weeks.

pulmonary diseases are a common cause of mortality and morbidity worldwide. chronic obstructive pulmonary disease (copd) causes respiratory muscle weakness, but also causes hypercapnia, dyspnoea, oxygen desaturation, and gait disturbances. in copd, the main symptom is dyspnea and leads to activity limitation. it has been shown that with exercise, the diaphragm workload increases in copd patients and requires more mip than healthy humans. this is associated with dyspnea during exercise and tiredness in the respiratory muscles. dyspnea is defined as the difficulty in breathing of a person. painful situations are defined as 'kinesiophobia' as a result of physical injuries and fear of repetition of the problem as a result of injury. similarly, copd patients avoid themselves from dyspnea-related activities or compensate by reducing the rate of activity. this reduces the severity of the symptom that precedes the symptom that may occur. as a result, fear of movement occurs due to dyspnea. decrease in the level of activity; social isolation, fear of dyspnea, depression and anxiety result in a stubborn cycle, reducing the quality of life. in order to increase respiratory muscle strength and endurance, to improve the length tension relationship of respiratory muscles and to increase respiratory capacity, respiratory muscle training is performed by using the training principle of skeletal muscles. in copd, inspiratory muscle training has been shown in many studies to reduce dyspnoea perception, increase exercise capacity and quality of life.

Eligibility criteria:
inclusion criteria: * fev1/fvc\<%70 * to be able to read and understand turkish exclusion criteria: * having undergone a copd exacerbation in the last 6 weeks * having comorbidities affecting ambulance * having cognitive disorders

Keywords: dyspnea inspiratory muscle training kinesiophobia
the impact of telemonitoring in the management of hypertension

Conditions: Health Services Administration; Telemedicine; Hypertension

Summary: rater blinded, multi-center, prospective, randomized controlled study comparing mean 24 hour systolic blood pressure of eligible hypertensive patients in the telemonitorin group versus the usual care group, at 6 months after inclusion.


Eligibility criteria:
inclusion criteria: included are patients with: * age ≥ 35 years old * newly diagnosed hypertention * uncontrolled hypertention exclusion criteria: excluded are patients with: * orthostatic hypotension * chronic renal failure (serum creatinine \> 200 micromol / l) * acute coronary syndrome * coronary revascularization or stroke within the past 3 months * known secondary causes of hypertension * pregnancy * new york heart association class iii or iv heart failure or left ventricular ejection fraction \< 30% * dementia or another cause that prevents the application of remote monitoring

Keywords: telecommunication telecare teleconsult telemanagement telemonitoring
diclofenac phonophoresis versus high power pain threshold ultrasound on patients with neck pain

Conditions: Neck Pain

Summary: the aim of this study is to investigate the effect of diclofenac phonophoresis versus high power pain threshold ultrasound in patients with mechanical non-specific neck pain

neck pain can be a long-lasting condition, between half and three quarters of patients with neck pain will experience recurrence within 1-5 years. costs for the society due to neck pain are consequently high. neck pain (np) is one of the common musculoskeletal problems. np can be caused by the stress over the musculoskeletal system due to postural disorders and may also be associated with other causes such as intervertebral disc herniation, nerve compression, or fracture. musculoskeletal pain due to trigger points is one of the most prevalent reasons for patients to seek treatment. the aim of physical therapy treatment in patient with myofascial pain syndrome is to reduce the pain and restore normal function. most physical therapy treatments for mps are targeted to the deactivation of mtrps. physical therapy techniques include manual therapies; such as ischemic compression, spray and stretch, strain and counter strain, muscle energy techniques, trigger point pressure release, transverse friction massage; needling therapies, and other techniques such as thermotherapy, ultrasound therapy , phonophoresis and laser therapy.due to the semi-solid properties, a special method is needed for transdermal permeation of lidocaine. therefore, many studies have focused on enhancing the level of transdermal permeation by either changing the physiochemical properties of lidocaine or using physical modalities in particular, there has been considerable interest in transdermal permeation using various methods based on the idea that the amount and depth of transdermal permeation can be increased using various physical modalities. patients with mechanical neck pain will be allocated randomly into three equal groups; group a will receive phonophoresis and traditional therapy, group b will receive high power pain thresholdand traditional therapy and group c will receive traditional therapy

Eligibility criteria:
inclusion criteria: 1. diagnosed as non-specific neck pain with upper trapezius and suboccipital muscles active myofascial trigger points less than 3 months of duration and have these criteria: taut band on palpation, hyper sensible tender spot in the taut band, local twitch response referred pain pattern 2. body mass index from 18 to 25 kg/m2 3. their ages from 18-30 exclusion criteria: 1. if they had trigger point injections within the past 6 months 2. history of neck or upper back surgery, trauma or fracture 3. history of a whiplash injury, skin diseases and lesions, any sensory disturbances, any vascular syndromes, neck and back deformities 4. cervical radiculopathy, and diagnosis of fibromyalgia syndrome, skin diseases

Keywords: phonophoresis high power pain threshold ultrasound neck pain
periodontal therapy effect on the ratio of tnf-α to il-10 in periodontis with/out dm

Conditions: Periodontitis Generalized

Summary: periodontitis is a chronic inflammatory disease affecting the periodontium, characterized by irreversible damage to the gingiva, periodontal ligament, and alveolar bone. it is prevalent among adults, significantly impacting oral health and quality of life. this study investigates the effect of non-surgical periodontal therapy (nspt) on the levels of tumor necrosis factor-alpha (tnf-α) and interleukin-10 (il-10) in periodontitis patients with and without diabetes mellitus type ii.

a single-blinded, randomized clinical trial was conducted on 36 patients with generalized periodontitis, recruited from ain-shams university's outpatient clinic. patients were divided into three groups: poorly controlled diabetes with periodontitis (hba1c ≥ 7%), controlled diabetes with periodontitis (hba1c \< 7%), and non-diabetic periodontitis. full-mouth nspt was performed, and clinical parameters (plaque index, bleeding index, pocket depth, clinical attachment level) were assessed at baseline and eight weeks post-treatment. venous blood samples were collected to measure tnf-α and il-10 levels using elisa kits.

Eligibility criteria:
inclusion criteria: * both genders. age (20-50 ) years old. participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study. generalized periodontitis patients . having at least 20 tooth excluding wisdoms. systemically free according to the modified burkett's health history questionnaire except for diabetes mellitus (burket, greenberg and glick 2003). exclusion criteria: * smokers. * intake of immunosuppressive drugs, antibiotics or anti-inflammatory drugs throughout the last three months prior to the study . * status of pregnancy or lactation. * allergy to local anesthetic. * prisoners . * the vulnerable group ; mentally and physically disabled patients .
mesenchymal stem cells with therapeutic hypothermia for infants with perinatal hypoxic-ischemic encephalopathy

Conditions: Perinatal Anoxic-ischemic Brain Injury; Mesenchymal Stem Cell

Summary: perinatal hypoxic-ischemic encephalopathy (hie) remains a significant cause of neonatal morbidity and mortality. while therapeutic hypothermia (th) has been established as the standard treatment, many infants continue to experience adverse neurodevelopmental outcomes. mesenchymal stem cells (mscs), known for their neuroprotective, anti-inflammatory, and regenerative properties, offer a promising adjunctive therapy. the goal of this study is to evaluate the safety and feasibility of administering allogeneic wharton's jelly-derived mscs administered intravenously in neonates with moderate to severe hie after receiving th. the study population includes infants ≥34 weeks gestation diagnosed with moderate to severe hie who have completed th and are clinically stable. the main questions it aims to answer are: does intravenous msc administration after therapeutic hypothermia reduce the risk of death or neurological disability at 1 year of age compared to placebo? does this intervention improve neurodevelopmental outcomes at 2 years of age? researchers will compare infants randomized to receive mscs with those receiving placebo to assess clinical safety, mortality, and neurodevelopmental outcomes. participants will: be randomly assigned to receive either a daily intravenous dose of mscs or placebo for 3 consecutive days, with the first dose administered within the first 10 days of life. be monitored for immediate adverse events and vital signs during and after each administration. undergo serial follow-up assessments including neuroimaging at 1 month and neurodevelopmental evaluations at defined intervals up to 2 years of age.


Eligibility criteria:
inclusion criteria: * term and late-preterm infants (gestational age ≥34 weeks) * diagnosed with moderate to severe hie based on modified sarnat staging * received th per standard protocol * parental consent obtained exclusion criteria: * major congenital anomalies or genetic syndromes * severe sepsis or active infection * severe coagulopathy or bleeding disorders * multi-organ failure

Keywords: perinatal hie mesenchymal stem cells wharton&amp;#39;s jelly therapeutic hypothermia
fistulotomy with or without marsupialization for treatment of simple anal fistula

Conditions: Anal Fistula

Summary: patients with simple anal fistula will undergo fistulotomy operation and will be divided into two groups: the first will undergo marsupialization of the laid open fistula track and second group will not undergo marsupialization. the effect of marsupialization on healing of anal fistula will be compared postoperatively.


Eligibility criteria:
inclusion criteria: * both genders * age: 18-65 years * all patients with primary simple anal fistula (subcutaneous, intersphincteric, or low trans-sphicnteric involving less than 25% of external anal sphincter fibers). exclusion criteria: * high trans-sphincteric, extra-sphincteric, supra-sphincteric, secondary. * recurrent anal fistulas. * patients associated with anorectal pathology such as anal fissure, hemorrhoids, rectal prolapse, neoplasm, solitary rectal ulcer, inflammatory bowel diseases and tb. * high risk patients according to asa (american society of anesthesiologists ) * any degree of incontinence. * patients with previous anal surgery.
study of ravulizumab in proliferative lupus nephritis (ln) or immunoglobulin a nephropathy (igan)

Conditions: Lupus Nephritis; Immunoglobulin A Nephropathy

Summary: the objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (iv) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with ln (ln cohort) or igan (igan cohort).

this study consists of a 6-week screening period, 26-week initial evaluation period, a 24-week extension period, and a 36-week post-treatment follow-up period.

Eligibility criteria:
inclusion criteria: common to both disease cohorts: * proteinuria ≥1 (gram \[g\]/day or g/g) * vaccinated against meningococcal infection * vaccinated for haemophilus influenzae type b (hib) and streptococcus pneumoniae according to national/local regulatory requirements for ln cohort: * diagnosis of active focal or diffuse proliferative ln class iii or iv * clinically active ln, requiring/receiving immunosuppression induction treatment for igan cohort: * diagnosis of primary igan * compliance with stable and optimal dose of renin-angiotensin system inhibitor treatment for ≥ 3 months exclusion criteria: common to both disease cohorts: * egfr \< 30 milliliters/minute/1.73 meters squared * previously received a complement inhibitor (for example, eculizumab) * concomitant significant renal disease other than ln or igan * history of other solid organ or bone marrow transplant * uncontrolled hypertension for igan cohort: * diagnosis of rapid progressive glomerulonephritis * prednisone or prednisone equivalent \> 20 milligram (mg) per day for \> 14 consecutive days or any other immunosuppression within 6 months

Keywords: glomerulonephritis iga lupus nephritis complement c5