Kornimate/medical-research-clean huggingface dataset:
study of metabolic syndrome in young patients who are acute lymphoblastic leukemia survivors and their healthy siblings

Conditions: Leukemia

Summary: rationale: gathering information about metabolic syndrome from young patients who have survived acute lymphoblastic leukemia (all) may help doctors learn more about the disease. purpose: this phase i trial is studying the metabolic syndrome in young patients who have survived acute lymphoblastic leukemia and in healthy sibling volunteers.

objectives: * determine the prevalence of the metabolic syndrome (ms) and its component traits (i.e., obesity, hypertension, dyslipidemia, and insulin resistance) in survivors of childhood acute lymphoblastic leukemia and in healthy sibling volunteers. * identify host- and treatment-related risk factors for ms. outline: this is a multicenter study. patients' medical charts are reviewed and patients undergo anthropometric measuring (height and weight for bmi calculation and waist and hip circumferences) and blood pressure testing. patients also complete questionnaires on their physical activity, diet, and family history over 30-45 minutes. blood is collected to measure cytokines (e.g., adiponectin, leptin, interleukin-6, and c-reactive protein), fasting glucose, and fasting insulin. healthy volunteers undergo anthropometric measuring and blood pressure testing (if they are seen in the clinic). they also complete a baseline medical history and questionnaires on their physical activity and diet.

Eligibility criteria:
inclusion criteria: disease characteristics: * meets one of the following eligibility criteria: * childhood acute lymphoblastic leukemia survivor * less than 22 years old at diagnosis * treated from 1990-2007 at one of the following locations: * fred hutchinson cancer research center and/or children's hospital and regional medical center in seattle, wa * vanderbilt children's hospital in nashville, tn * meets 1 of the following treatment criteria: * completed conventional therapy ≥ 11 months ago and in first complete remission * received an allogeneic hematopoietic cell transplantation ≥ 11 months ago and in complete remission * no evidence of recurrent disease * healthy volunteer * full sibling of enrolled cancer survivor * age 8-21 (if more than 1 eligible sibling, sibling of closest age is preferred) * no history of cancer patient characteristics: * able to speak, read, and write english prior concurrent therapy: * see disease characteristics * no active treatment for graft-vs-host disease exclusion criteria: * lack of ability to speak, read, and write english * active treatment for graft versus host disease

Keywords: cancer survivor healthy, no evidence of disease long-term effects secondary to cancer therapy in children childhood acute lymphoblastic leukemia in remission
cov-pics: a virtual post-icu clinic

Conditions: Post ICU Syndrome

Summary: this is a pilot study to evaluate the feasibility of a covid-19 virtual post intensive care syndrome (pics) clinic (cov-pics). the findings from this study are the first steps in determining the feasibility and potential impact of a telehealth pics clinic that is able to address the needs of patients with covid-19 disease and potentially other patients that are unable to attend a brick and mortar clinic and require virtual care.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * covid-19 diagnosis with a stay in the icu. * a home internet connection or smartphone access, along with the ability to use them * missouri resident exclusion criteria: * severe cognitive deficits or dementia prior to hospitalization * long-term resident of a skilled nursing facility prior to admission * non-english speaking (will not have an interpreter available) * hospice or comfort care at discharge * no plans to return to some degree of independent living at the time of discharge * pregnant at the time of discharge * prisoner at the time of discharge * blind * deaf
couple hopes (helping overcome ptsd and enhance satisfaction)

Conditions: Posttraumatic Stress Disorder

Summary: posttraumatic stress disorder (ptsd) is a common and disabling condition associated with intimate relationship problems and mental health problems in partners of those with ptsd. recognizing the need to improve access to evidence-based interventions for those with ptsd and their families, our team has developed an internet-delivered, self-help intervention to improve ptsd, enhance relationships, and improve partners' mental health: couple hopes (helping overcome ptsd and enhance satisfaction). couple hopes presents text and video-based content across seven self-help intervention modules, with modest support from paraprofessional coaches. although the couple hopes platform has been developed, it remains uncertain whether couple hopes is feasible, usable, and efficacious in reducing ptsd and enhancing intimate relationship functioning. the proposed project aims to refine and finalize couple hopes with couples that include a veteran, service member or first responder with significant ptsd symptoms. this project includes initial testing of the intervention's preliminary efficacy, safety, and feasibility in a series of 10 couples (phase 1), then in an uncontrolled trial of 20 couples (phase 2), and then a randomized clinical trial comparing its efficacy to a delayed intervention control condition in 70 couples. potential benefits of this study include couples learning new skills to reduce ptsd symptoms and enhance relationship functioning, although this is not guaranteed. risks include participants finding the assessments distressing, or possible worsening of ptsd symptoms or relationship functioning. these risks will be mitigated by continuous monitoring of ptsd symptoms, relationship functioning, and adverse events, and intervention by study staff.


Eligibility criteria:
inclusion criteria: * individual who is a canadian military member, veteran, or first responder with clinically significant levels of ptsd symptoms * must be willing to be audio-recorded for coaching sessions * intimate partner willing to participant and complete intervention modules together * access to high speed internet exclusion criteria: * elevated suicide risk * severe physical aggression between partners in the past year * clinically significant ptsd symptoms in both members of the dyad

Keywords: self-help internet-delivered intervention
benefit of permanent stimulation of the left branch of the his bundle versus right ventricular stimulation after atrioventricular node ablation for rapid atrial fibrillation

Conditions: Atrial Fibrillation Rapid

Summary: the objective of the study is to evaluate the functional benefit of left bundle branch of his pacing compared to right ventricular pacing in patients implanted with a pacemaker prior to a atrioventricular node ablation procedure for rapid atrial fibrillation


Eligibility criteria:
inclusion criteria: 1/ pacemaker implanted patient with lbtp lead and back-up right ventricular lead who subsequently underwent successful atrioventricular node ablation for rapid af 2) nav ablation procedure performed less than 15 days ago 3) age ≥ 18 years 4) woman of childbearing age with effective contraception (estrogen-progestin or intrauterine device or tubal ligation) for at least 1 month and for the duration of the study, and a negative urine pregnancy test by b-hcg at inclusion or, postmenopausal woman: confirmatory diagnosis (non-medically induced amenorrhea for at least 12 months prior to the inclusion visit). 5) membership of a social security scheme 6) patient follow-up feasible 7) patient has read and understood the information leaflet and signed the informed consent form exclusion criteria: 1. impairment of autonomy such that a maximal cardiorespiratory effort test (vo2 max test) cannot be performed under good conditions (adl scale \< 5). 2. lvef \< 40% at inclusion 3. person deprived of liberty by an administrative or judicial decision, or person under court protection, sub-guardianship or curatorship. 4. patient participating in another interventional trial 5. any history of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol, or from giving informed consent. 6. pregnant, parturient or breast-feeding women, or those without proven contraception
dorsal versus volar approach for capflex-pip© implantation

Conditions: Osteoarthritis

Summary: the primary objective is to investigate the active extension six months after implantation of the capflex-pip© arthroplasty, comparing the dorsal with the volar approach. this is a randomized controlled trial including 70 patients with pip oa indicated for capflex arthroplasty.

the capflex-pip© implant is a modular gliding surface proximal interphalangeal (pip) joint prosthesis. for implantation, there are two approaches available: the dorsal central split approach according to swanson and the volar approach described by simmen. our experiences and data from our prospective registry indicate, that the active extension of the pip joint is better after the dorsal approach, but sometimes related with hyperextension of the pip joint and secondary swan-neck deformity. extension is supposed to be better after the volar approach, but associated with active and passive extension lag. evidence of theses experiences will assist the surgeon in the preoperative planning to select the appropriate approach according to the patient's needs. the primary objective is to investigate the active extension six months after implantation of the capflex-pip© arthroplasty, comparing the dorsal with the volar approach. this is a randomized controlled trial.

Eligibility criteria:
inclusion criteria: * indication for capflex-pip© arthroplasty * patient aged 18 years and over * informed consent as documented by signature exclusion criteria: * revision surgery * capflex-pip© arthroplasty at the thumb ip joint * major surgery at the same finger (e.g. dip arthrodesis) * ulnar/radial deviation of the pip joint \> 15° * patients in which a reconstruction of the collateral ligaments has to be performed * general medical contraindication to surgery * german language barrier to complete the questionnaires * any disease process that would preclude accurate evaluation (e.g. neuromuscular, psychiatric or metabolic disorder) * pregnancy * surgery not planned by dr. herren, dr. schindele or dr. bodmer * legal incompetence
resiliency programming for caregivers of children with learning and attentional difficulties

Conditions: Parenting; Stress; Learning Disabilities, Child; Attention Difficulties

Summary: this is a randomized open pilot trial enrolling up to 40 co-primary caregivers of children with lad. participants will be randomized to receive either mind-body resiliency group (smart-lad, intervention) or an evidence-based group intervention health education program (hep, control) which is a multiple behavior change program that addresses sleep, exercise, nutrition, substance use, and working with one's healthcare team. both the smart-3rp and hep programs have been modified based on adaptions from our previous qualitative study.

the primary objective of this protocol is to conduct an open pilot to elicit initial quantitative and qualitative feedback regarding feasibility and acceptability of the interventions (smart-3rp and hep) that we have refined. both groups are designed to improve well-being for caregivers experiencing stress-related to caring for a child with lad. the investigators will ask participants to complete approximately 15-minute survey batteries via redcap at baseline and after the 8-week program, including assessments of intervention feasibility and acceptability as well as psychosocial outcomes. to inform plans for ongoing program refinement, the investigators will also elicit specific feedback regarding study assessment tools, recruitment procedures, and group composition. results will be used to inform a larger randomized trial.

Eligibility criteria:
inclusion criteria: * english-speaking * age 18 or older * ability to participate in group, virtual sessions including access to computer, tablet, or smartphone, and internet * parents or guardians of a child (\< age 18) with lad. exclusion criteria: * parents with significant psychiatric conditions (i.e., active suicidality or psychosis) or who are otherwise unable to participate, at the investigators' clinical discretion. * only one parent per family can participate. * unwilling or unable to participate in the study * considered medically or otherwise unable to participate by the study pi

Keywords: resiliency training stress management learning and attentional disabilities
asan medical center aortic valve replacement registry

Conditions: Aortic Valve Stenosis

Summary: this study evaluates the effectiveness and safety of surgical aortic valve replacement and transcatheter aortic valve replacement in aortic stenosis.

all tavr and savr cases will be enrolled retrospectively and prospectively. this registry includes sub group analysis named strategy as(role of sarcopenia and frailty in predicting outcomes after transcatheter or surgical aortic valve replacement in elderly patients with aortic stenosis: a prospective cohort study). for this sub group analysis, all enrolled subjects will have following tests : eq-5d, kccq-12(kansas city cardiomyopathy questionnaire), adl(activities of daily living), iadl(instrumental. activities of daily living), nagi \& rosow-breslau self-reported items, previous fall events since 6 months (initial) or last visit(f/u), ipaq(the international physical activity questionnaires), social frailty screening, ces-d(center for epidemiologic studies depression scale), mna-sf(mini nutritional assessment - short form),sppb score (short physical performance battery, usual gait speed, balance, chairstand), multi-task gait test (counting7, animal, motor, motor\&counting7), grip strength, bioimpedance analysis, muscle tone at thigh and calf, uef (upper extremities function).

Eligibility criteria:
inclusion criteria: * all successful transcatheter aortic valve replacement or surgical aortic valve replacement * written consent exclusion criteria * infective endocarditis

Keywords: tavr tavi savr
renal anemia refractory to erythropoietin

Conditions: ESRD; Renal Anemia

Summary: this study evaluates the renal anemia refractory to epo . in hemodialysis patients. all of participants will receive epo. and identify various factors contributing to etiology of renal anemia in epo- resistant patients.

chronic kidney disease (ckd) is considered a public health problem worldwide with high incidence and prevalence rates.anemia is one of the most frequent early complication of ckd. the main cause is erythropoietin (epo) deficiency due to impaired kidney function however, other causes should be considered when the severity of anemia is inconsistent with the decrease in renal function; when there is evidence of iron deficiency or matching decreases in hemoglobin, leukopenia and/or thrombocytopenia are also found

Eligibility criteria:
inclusion criteria: * patients greater than or equal to 18 years old with ckd on hemodialysis exclusion criteria: 1. - evidence of infections especial of vascular access . 2. - malnutrition and manifestation of iron, b12, folate and protein deficiency . 3. - any underling cause as; * hematologic malignances -hemolytic anemia - * aplastic anemia (infection and/or bleeding with anemia) * solid tumors * bleeding (skin ,mucosal ,orificial) * evidence of mineral bone disease (ckd-mbd) * others
bevacizumab treatment for type 1 rop

Conditions: Retinopathy of Prematurity

Summary: type 1 retinopathy of prematurity in zone i represents the most severe type of rop and has the worst prognosis. it is unknown whether low-dose bevacizumab will be successful in these severe cases. also unknown is the timing and extent of peripheral retinal vascularization after low-dose bevacizumab compared with the standard dose. the current study will evaluate whether doses of 0.063 mg and 0.25mg are effective as treatment for type 1 rop, with rop and retinal vessels all in zone i.

infants with type 1 rop and no prior treatment for rop will be randomly assigned (1:1) to treatment with either intravitreous bevacizumab 0.063 mg or either intravitreous bevacizumab 0.25 mg. study exams will be at 1 day, 4 days (if no improvement on day 1), 1, 2, 3, and 4 weeks, and at 2 and 4-months post-treatment (and re-treatment when indicated). additional study exams will occur at adjusted age 6 and 12 months. non-study examinations will be at clinician discretion and are likely to occur more often. the primary outcome will be treatment success within each dose group, defined as improvement by the day 4 exam and no recurrence of type 1 rop or severe neovascularization requiring additional treatment within 4 weeks of injection. important secondary outcomes include safety and efficacy. refractive outcomes, and the extent of retinal vascularization at 2 and 4 months post-injection between the two dose groups.

Eligibility criteria:
inclusion criteria: the study participant must have at least one eye meeting all of the inclusion criteria in order to be eligible to participate: 1. birth weight \< 1251 grams 2. newly diagnosed (within 2 days) type 1 rop in zone i in one or both eyes exclusion criteria: participants meeting any of the following exclusion criteria will be excluded from study participation. 1. previous treatment for rop 2. stage 4 or 5 rop in either eye 3. treatment could not be done within 2 days of diagnosis of type 1 rop 4. investigator unwilling to randomize or parent unwilling to accept randomized assignment to either treatment 5. transfer to another hospital anticipated within the next 4 weeks where exams by study-certified examiners are not available. if hospital discharge is anticipated within the next 4 weeks, parents unable or unwilling to return to the pedig site for outpatient follow-up visits. 6. active ocular infection or purulent nasolacrimal duct obstruction in either eye one eye will be excluded, and other eye may be eligible, if either of the following are present: * visually significant ocular anomaly (e.g., cataract, coloboma) * opacity that precludes an adequate view of the retina
on general well-being, anxiety, and physical activity in pregnant women

Conditions: Pregnancy

Summary: 60 pregnant women will be randomly divided into 2 groups. participants in the control group will be given pregnancy counseling that includes only nutrition, walking (3 days a week for 30 minutes), and breathing exercises, and will be called for 1st, 2nd and 3rd month check-ups. in addition to pregnancy counseling, the qigong group will receive 2 qigong training sessions, one via zoom and one face-to-face, and then the training videos of each exercise will be sent via whatsapp. paricipants will be asked to do the qigong exercises at home for 30 minutes, 3 days a week for 12 weeks. these participants will be called for 1-month, 2-month and 3-month check-ups. blood pressure and sugar measurements will be recorded at the first visit, 1st month, 2nd month and 3rd month check-ups, and patients will also be evaluated with the pregnancy physical activity questionnaire, pregnancy stress assessment scale, pregnancy-related anxiety scale, pregnancy exercise self-efficacy questionnaire. after the recruitment period the results will be evaluated statistically.


Eligibility criteria:
inclusion criteria: * pregnant women between the ages of 18-40 who have a new pregnancy detected by usg * pregnant women whose pregnancy week is compatible with fetal development, who do not have any problems and who will not have any problems exercising exclusion criteria: * those with risky pregnancies (cervical dilation, bleeding, premature membrane rupture, etc.) \*\&lt;18 and \&gt;40 years old pregnant women * those with cardiovascular disease or hypertension * those with uncontrolled diabetes * those with uncontrolled thyroid disease * those with a previous risky pregnancy or a complication * those with an operation, metabolic bone disease or joint limitation that will prevent them from exercising * those who are included in another pregnancy counseling or physical activity program * those who do not give their consent for the study, do not come to regular pregnancy check-ups or have incomplete information will be excluded from the study.
assesment of complications and surgery timing in postcovid thoracotomy patients: single center experience

Conditions: Thoracotomy

Summary: covid-19 infection has caused delay in many surgeries. besides covid -19 infection may be a potential problem in especially major surgeries such as thoracotomies. surgery timing, complications, intensive care unit stay and vaccination status are important issues that should be learned from post-covid cases.the aim of the study is to learn lessons from post-covid thoracotomy cases.

patients who had covid-19 infection before thoracotomy were assessed by their datas, postoperative complications, intensive care unit stay, vaccine status, time period between covid infection and surgery were collected from patients' files and statistical analysis performed.

Eligibility criteria:
inclusion criteria: * undergoing thoracotomy * had covid infection before surgery exclusion criteria: * age under 18 * missing data

Keywords: thoracotomy covid infection complication
comparison of 2 pupillometric indices in cerebral brain patients

Conditions: Pupillometry Index in Brain Lesion

Summary: pupillary examination, and in particular pupillary reactivity to light, is fundamental to the monitoring and follow-up in intensive care units of patients with acute brain injury. a pupillometric index combining different parameters of pupillary light reflex has been described as predictive of intracranial hypertension and the neurological outcome of the patient.

pupillary examination, and in particular pupillary reactivity to light, is fundamental for the monitoring and follow-up in intensive care units of patients with acute brain injury. intracranial pressure monitoring and pupillometry measurement are thus part of the routine practice of intensive care unit management of brain injured patients. furthermore, elevated intracranial pressure in brain injured patients admitted to the icu is associated with a poor prognosis, and very high intracranial pressure is a life-threatening situation. a pupillometry index combining different parameters of pupillary light reflex has been described as having predictive value of intracranial hypertension and neurological outcome of the patient: the "npi". another manufacturer idmed, marseille, france proposes an index: the qpi (quantitative pupillometry index), based on a statistical classification of the amplitude of the light reflex. the aim of this study is to show that : * qpi is equivalent to npi * an abnormal value of the pupillometry indexes (npi/qpi) is predictive of high intracranial pressure. * an abnormal value of pupillometry indexes (npi/qpi) is predictive of a poor neurological outcome at 6 months.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age * patients admitted for any brain injury: traumatic, intracranial hemorrhage, subarachnoid hemorrhage * pupillometry available as a standard assessment tool. * patient intubated/ventilated for neurological reasons for more than 12 hours exclusion criteria: * non-intensive care patients * facial and or ocular trauma not allowing pupillometry evaluation * patients admitted to the icu with a life expectancy of \< 24 hours * protected persons (under guardianship, curators, pregnant or breastfeeding women, persons deprived of liberty, persons not subject to a psychiatric measure) * patients not affiliated to a social security system * patients who object to the use of their data for research purposes

Keywords: brain lesion pupillometry index neurological outcome