Kornimate/medical-research-clean huggingface dataset:
a single-session intervention for adolescents and young adults with internalizing problems

Conditions: Anxiety; Depressive Symptoms

Summary: with the increasing number of adolescents and young adults (aya) experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, aya need a mental health intervention that is affordable and easily accessible. a single-session intervention (ssi), project personality, was developed to improve youth growth mindset and reduce symptoms of internalizing problems, such as anxiety and depression. the purpose of this pilot study is to determine the feasibility of an ssi in adolescents and young adults at a reproductive community health center.

the mental health of adolescents and young adults (aya) has greatly been impacted since the beginning of the pandemic. with the increasing number of aya experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, aya need a mental health intervention that is affordable and easily accessible. a single-session intervention (ssi) focused on cultivating an aya's growth mindset has potential to overcome common barriers to care, such as cost, transportation and stigma related to psychological treatment. furthermore, research shows having a fixed mindset correlate and can predict higher depressive and anxiety symptoms. teaching adolescents about growth mindsets could decrease the risk of internalizing symptoms. the ssi, project personality, was developed to improve youth growth mindset and reduce symptoms of internalizing problems, such as anxiety and depression. the purpose of this pilot study is to determine the feasibility of an ssi in adolescents and young adults at a reproductive community health center.

Eligibility criteria:
inclusion criteria: * the adolescent or young adult is between the ages of 13 and 24. * the adolescent or young adult has a score above 5 on either phq-9 (patient health questionnaire-9) or gad-7(general anxiety disorder-7). * the adolescent and their parent participating in the study, or the young adult can read and comprehend english. exclusion criteria: * the adolescent or the young adult has severe current suicidal/homicidal ideation and/or self-injury requiring medical intervention as defined by the asq (ask suicide-screening questions). * the adolescent and their parent participating in the study, or the young adult cannot read or comprehend english. * the adolescent and their parent participating in the study, or the young adult cannot travel to the baylor college of medicine (bcm) teen health clinic to receive the single-session intervention.

Keywords: depression anxiety growth mindset neuroplasticity
examining the effect of piano playing training on fine motor skills in parkinson's patients

Conditions: Parkinson Disease

Summary: piano playing may provide an engaging and accessible setting for finger and wrist movement training. moreover, it has been found effective for improving manual dexterity and upper-limb function in other neurologic disorders, such as stroke and additionally beneficial for cognitive and psychosocial support in parkinson's disease. however, no study has examined the effect of piano playing on dexterity in parkinson's disease. the aim of this study is to test the efficacy of a novel piano-based training program on fine motor function in patients with pd. participants with parkinson's disease will take part in an individually tailored 6-week piano training program, combining weekly supervised training sessions (6x60 min altogether), with three independent at-home weekly 30 minutes practice sessions (18x30 altogether). participants will receive a piano midi keyboard for home use during the study.


Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease patients * hoehn and yahr stages i to iii * self-reports of some dexterity difficulties exclusion criteria: * participation in an ongoing clinical study or clinical study within 30 days prior to this study * atypical parkinsonian syndrome or secondary parkinsonism (e.g., due to drugs, metabolic neurogenetic disorders, encephalitis, cerebrovascular disease, or other degenerative disease), or other neurologic conditions influencing upper limb movement * significant psychiatric symptoms or history * significant or recent experience in piano playing (participants who are proficient piano players, or had studied piano for more than 3 years in the past, or for shorter periods in the last 5 years) * other significant fine motor skills (e.g., high proficiency in playing another musical instrument, video games, etc.) * mini mental status examination (mmse) score below 25 * significant sensory deficits, e.g., hearing or sight impairment * unstable medical disorder * significant postural or action tremor, moderate dyskinesia

Keywords: music piano dexterity
metabolic fate modifications of saturated fats after an overfeeding

Conditions: Obesity; Lipid Metabolism; Inflammation

Summary: the purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. the method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_c16) in lipoprotein triglycerides (tg-chylomicron and tg-vldl) and in free fatty acids (ffa).

healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 kcal/day. during two exploration days (before : d0 et after : d56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_c16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. the enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (gc-oms) in palmitic acid pool of lipid fractions.

Eligibility criteria:
inclusion criteria: * 18 to 55 years old * bmi 18 to 30 kg/m² * stable physical activity * safety subject during medical consultation exclusion criteria: * medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases) * drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones) * eating disorder * intensive sportive activity * subjects who smoke * claustrophobic subjects

Keywords: overfeeding stable isotopes lipoprotein metabolism lipid oxidation fat distribution gene expression endotoxemia mass spectrometry/gas chromatography
impact of daily, digital and behavioral tele-health tapering program for perioperative surgical patients exposed to opioids and benzodiazepines.

Conditions: Elective Spine Surgery Receiving Pre and/or Postoperative Pain Control With Opioids

Summary: the purpose of this study is to examine the safety, acceptability, and feasibility of a controlled taper off of opioids and/or benzodiazepines, with the use of behavioral health tele-health based therapy services, in the perioperative patient.


Eligibility criteria:
inclusion criteria: * preoperative benzodiazepines opioid dependence (daily use of opioids or benzodiazepines preoperatively) (naive: no meds 30 days prior to surgery,opioid tolerant/dependant: use of meds on most days for 1 or more months prior to surgery) * subject willing to use lucid lane program to provide behavioral health support perioperative period up to 6 months post-op for tolerant opioid/benzo users * subject is willing to discuss lucid lane progress with the university of texas health science center(uthealth) perioperative team and prescribing clinicians * subject is willing to sign a lucid lane client agreement * willing to sign an informed consent exclusion criteria: * serious mental illnesses including schizophrenia-spectrum disorders, severe bipolar disorder, and severe major depression. * active suicidal ideations * patients on methadone or buprenorphine for treatment of opioid use disorder (i.e. for treatment of addiction, and not for treatment of pain) * patient unwilling to use or not possessing access to a device that allows for video visits (e.g. a smartphone, tablet, or computer) * patients who are on palliative care * insufficient ability to use english to participate in the consent process, the intervention or study assessments. * insufficient ability to provide informed consent to participate * if the patient misses more than 2 lucid lane sessions per week, the staff will be immediately notified by lucid lane.

Keywords: opioid taper post-surgery behavioral tele-health
the correlation between hrd detection and the efficacy of parp inhibitors in ovarian cancer

Conditions: Ovarian Neoplasms

Summary: clinicopathological data were collected from ovarian cancer patients treated with parp inhibitors, with follow-up imaging conducted before and after treatment. the efficacy was evaluated according to recist criteria, comparing the correlation between different hrd statuses and the efficacy of parp inhibitors in ovarian cancer.


Eligibility criteria:
inclusion criteria: * patients diagnosed with ovarian cancer (any histological type) and possessing complete pathological hematoxylin and eosin (he) stained slides and paraffin-embedded tissue blocks. * patients must be 18 years of age or older. * patients should not have concurrent multiple primary cancers. * patients must undergo an mri or ct scan prior to starting treatment. * according to recist (response evaluation criteria in solid tumors) criteria, patients must have at least one measurable lesion. * participants must provide informed consent, voluntarily cooperate with clinical follow-up, and sign an informed consent form. exclusion criteria: * patients who do not have accessible tumor tissue required for homologous recombination deficiency (hrd) testing. * patients whose clinical records are incomplete, making it impossible to effectively compare treatment efficacy. * patients who are lost to follow-up and for whom subsequent treatment outcomes cannot be tracked.

Keywords: ovarian neoplasms homologous recombination deficiency prognosis cost-effectiveness analysis
isolation and characterization of mammary stem cells

Conditions: Stem Cells

Summary: background: * cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. this deregulation seems to be necessary for cancer to develop. * these cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells. objective: to isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells. eligibility: * tissue samples will be obtained from the human cooperative network. * samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer. design: breast cancer stem cells will be isolated, grown in the laboratory and characterized.

cancers are composed of heterogeneous populations of cells with varying degrees of proliferative capacity and ability to reconstitute tumors when transplanted into nude or scid mice. recently, cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated. this deregulation seems to be the prerequisite for the development of cancer.

Eligibility criteria:
* inclusion criteria: the tissue samples will come from the human cooperative network. they have their own set of criteria. we are requesting tissue samples from individuals that are normal as well as those who have cancer. exclusion criteria: the tissue samples will come from the human cooperative tissue network and we are asking for normal samples from individuals who don't have any opportunistic diseases.

Keywords: mammary stem cells breast cancer cancer stem cells gene expression profiling
enhancing self-understanding and social integration of middle school students with learning disabilities

Conditions: Learning Disability

Summary: research and intervention programs for students with learning disabilities (ld) typically address child and family characteristics without examining the school context and conditions that affect adjustment. focusing on the student with ld can highlight the child and family's deficits. an ecological theoretical framework guides this research project, a collaboration of the university of toronto, faculty of social work and ontario institute for studies in education of the university of toronto (oise/ut), integra and the toronto catholic district school board. this framework is based on the assumption that people are very much part of and affected by social and environmental settings. accordingly, it is important not to see the adjustment problems of children with ld as being caused only by their ld. instead, their academic and social problems are seen as unfolding in larger circumstances that include other children, the classroom, the school, the family and the community. these many factors act together to influence the child with ld and must be taken into account along with individual characteristics of the child.

objectives 1. deliver an ecologically informed school-based intervention that addresses individual, social and environmental factors, to improve the adjustment of students with ld 2. examine the efficacy of the intervention 3. contribute to knowledge of the factors that influence the adjustment of students with ld 4. circulate this information to those who live and work with students with ld in order to offer understanding and direction for programs and interventions and to facilitate cross-sector collaboration the research will utilize both quantitative and qualitative methodologies. 6 schools will be selected. 3 will receive the intervention in year 1 (2004-2005 school year), comprising 1) group treatment, 2) workshops, and 3) consultation. the other 3 schools will be controls in year 1 and receive the intervention in year 2 (2005-2006 school year). students in grades 6-8, identified as having ld will be offered the opportunity to participate in the project (with parental consent). this project comprises 3 components: 1. school-based group treatment for students in grades 6-8 with ld and psychosocial problems. group treatment will focus on assisting participants to understand the impact of their ld as well as on development of self-advocacy skills. 2. workshops on understanding ld for teachers, parents, and students without ld (grades 6-8).

Eligibility criteria:
inclusion criteria: * grades 6-8 with identified ld * must demonstrate need for psychosocial intervention based on results on measures exclusion criteria: * cannot meet criteria for conduct disorder on the teacher report form

Keywords: school-based intervention learning disabilities ecological intervention
therapeutic benefit of incobotulinum toxin a for spasticity of the triceps surae in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: introduction/objectives: in this observational study, we assessed the benefit following an injection of 200 international units (iu) of incobotulinum toxina in patients with multiple sclerosis (ms) with spasticity of the triceps surae (ts) at 6 weeks (peak efficacy of toxin) and at 3 months (cancellation of efficacy). methods: this study enrolled all ms patients willing to participate with expanded disability status scale (edss) scores of less than 6, who required toxin for management of focal spasticity of the ts. treatment consisted of 200 iu of incobotulinum toxina injected into the ts. outcome measures were assessed before injection, at 6 weeks and 3 months post-injection, using the goal attainment scale (gas), twelve item ms walking (msws-12) scale, timed up and go (tug) test, 6 minute walk test (6mwt). spatiotemporal gait data was obtained by gaitrite.


Eligibility criteria:
inclusion criteria: * ms patients aged over 18 years * with gait problems related to spasticity of the triceps surae, * walking 10 m in less than a minute, * with or without technical assistance, * with an edss of 6.5 or less * triceps surae spasticity of between 1 and 3 on the modified ashworth scale. exclusion criteria: * comprehension problems preventing the patient from expressing his/her free and informed consent to the study. * intolerance to botulinum toxin; * botulinum toxin injection in the previous three months.

Keywords: gait multiple sclerosis spasticity toxin triceps surae
precision-exercise-prescription for lung cancer patients undergoing surgery: the pep study

Conditions: Non Small Cell Lung Cancer; Secondary Lung Cancer

Summary: this is a phase 3 study aimed at investigating the effects of a personalized exercise program (pep) in nsclc patients (stage i, ii, iiia) and secondary lung cancer patients undergoing surgical treatment at the university of utah and comparing the intervention to the current standard of care (no exercise program).

this is a phase 3 study aimed at investigating the effects of a personalized exercise program (pep) in nsclc patients (stage i, ii, iiia) and secondary lung cancer patients undergoing surgical treatment at the university of utah and comparing the intervention to the current standard of care (no exercise program). eligible patients will be randomized between two arms (1:1 ratio) prior to the surgery and will be followed for approximately 6 months post-surgery: * an intervention arm (referred to in materials as group 1) which features pre- and post-surgery pep interventions. * a control arm (referred to in materials as group 2) which does not include a personalized exercise program (the standard of care). patients randomized to the control arm will be given the opportunity to participate in a pep-intervention session providing exercise counseling after the 6 month assessment and will receive a free activity tracker for their participation.

Eligibility criteria:
inclusion criteria: * male or female subject aged ≥ 18 years. * diagnosis of primary lung cancer stage i, ii, or iiia or secondary lung cancer. * disease amenable to surgical resection in the opinion of the treating surgeon. * patients must be able to follow directions and complete questionnaires and exercise diaries in english. * patients must agree to be randomly assigned to either intervention or control group. exclusion criteria: * deemed ineligible for surgery by the enrolling physician * abnormalities on screening physical exam judged by study physicians or supervising physical therapist to contraindicate participation in exercise program compliance. * alcohol or drug abuse as judged by study physicians. * significant mental or emotional problems that would interfere with study participation will be assessed by the nccn distress thermometer. any value higher than 7 will trigger further intervention, but ultimately enrollment into the clinical trial will be determined by the enrolling physician.

Keywords: exercise
qol between cieds with and without rate adaptive pacing

Conditions: Pacemaker DDD; Quality of Life

Summary: clinical implantable electronic devices, such as permanent pacemaker, implantable cardioverter defibrillator and cardiac resynchronization therapy are used in current daily practice for patients with bradycardia, ventricular arrhythmia, or heart failure. the rapid progress of permanent pacemaker function is growing to replace human's degenerating electrophysiology of heart. the ability of physical work is an important cornerstone of quality of life. in daily activities, rate response to higher rate is importance for patients with bradycardia who can not accelerate their heart rate. and rate-adapting pacing of permanent pacemaker is a design to increase heart rate pacing according to physical activity or emotional activity. patients with rate-adaptive pacing will get more cardiac output and overcome the physical activity such as stair climbing. but there are few studies to evaluate whether the rate-adaptive pacing of permanent pacemaker will improve the quality of life in people with bradycardia. the aim of this study is to compare turn-on with turn-off this function (dddr vs ddd) whether rate-adaptive pacing will improve quality of life in patients with permanent pacemakers.


Eligibility criteria:
inclusion criteria: * sick sinus syndrome for permanent dual-chamber pacing * pacemakers are implanted for ≥30 days with no complications. exclusion criteria: * (1) patient or legal representative could not provide written informed consent * (2) unwillingness or inability to return for follow-up visits or reason to believe that adherence to follow-up visits wound be irregular, * (3) current or scheduled enrollment in other, conflicting studies, * (4) concomitant disease or other medical condition likely to result in death within 6 months, and

Keywords: rate adaptive pacemaker quality of life
simultaneous integrated boost preoperative radiotherapy for rectum cancer

Conditions: Rectal Cancer

Summary: the investigators propose a randomized non-inferiority trial that compares preoperative fluoro uracil (fu)-based chemoradiotherapy to radiotherapy with a simultaneous integrated boost. in patients with t3-4 rectal cancer, the latter approach is considered preferential with regard to toxicity and cost. the metabolic response of the tumor, as assessed by 18f-2-fluoro-2-deoxyglucose-positron emission tomography (18f-fdg pet) or pet-ct, will be used as a surrogate marker of cause specific outcome


Eligibility criteria:
inclusion criteria: * histopathologically confirmed rectal adenocarcinoma with an inferior border within 15 cm of the anal verge * the tumor has to have evidence of t3 or t4 disease on magnetic resonance imaging (mri) or endoluminal ultrasound exclusion criteria: * unresectable metastatic disease * eastern cooperative oncology group (ecog) performance status \> 3 * patients not deemed fit for radiotherapy, capecitabine or surgery * pregnant or lactating patients * women with child bearing potential who lack effective contraception * patients below 18 years old

Keywords: colorectal cancer colorectal neoplasms radiotherapy chemoradiotherapy t3-4 rectal cancer