Kornimate/medical-research-clean huggingface dataset:
oral administration of stc-15 in subjects with advanced malignancies

Conditions: Advanced Cancer; Advanced Solid Tumor; Cancer

Summary: this phase 1, multi-center, open-label, first-in-human study evaluates multiple ascending daily oral doses of stc-15 in q3w treatment cycles in a 3+3 cohort design with dose levels determined by a modified fibonacci algorithm. the study is designed to systematically assess safety and tolerability, pharmacokinetics, pharmacodynamics and clinical activity of stc-15 in adult subjects with advanced malignancies. dose levels for further evaluation in expansion cohorts will be selected based on all available pk, pharmacodynamic, target engagement, efficacy, safety, and tolerability data including long-term safety data beyond dose limiting toxicities (dlts). the study may be amended to evaluate stc-15 in combination with a food and drug administration-approved standard of care treatment regimen, which could encompass targeted/chemotherapy, radiation therapy and/or immunotherapy with immune checkpoint blockers.


Eligibility criteria:
key inclusion criteria: * \> 18 years of age * histologic or cytologic confirmation of advanced malignancy that has failed standard of care (soc) therapy and no further soc therapy is available or the subject has declined additional soc therapy * adequate organ and marrow function * ecog ps of 0 or 1 key exclusion criteria: * treatment with any local or systemic antineoplastic therapy within 3 weeks prior to first dose of stc-15 * major surgery or radiation within the 3 weeks * immune-related aes from immunotherapy that required permanent discontinuation * central nervous system (cns) disease involvement, or prior history of grade ≥3 drug-related cns toxicity. * active autoimmune disease that has required systemic treatment in the 2 years prior to screening

Keywords: oncology mettl-3 inhibitor
safety and feasibility of electrochemotherapy in unresectable colorectal adenocarninoma liver metastases

Conditions: Colorectal Adenocarcinoma

Summary: electrochemotherapy (ect) is a non-thermal tumour ablation modality. it consists of the local potentiation, by means of local reversible electroporation of tumour tissues, of the antitumor activity of non-permeant or poorly permeant anticancer drugs already possessing intrinsic cytotoxicity. ect has proved to be effective in the treatment of various cutaneous tumour nodules of any origin. mostly ect is offered to patients in case of multiple cutaneous metastases, when they cannot be excised, due to their number or localization. this study investigate the application of ect in the treatment of liver metastases from colorectal adenocarcinoma, for which other thermal cytoreductive methods would be risky compared to the supposed expected clinical benefits.


Eligibility criteria:
inclusion criteria: * male or female patients \> 18 years of age * histological confirmed colorectal adenocarcinoma * histological or clinically confirmed metastatic colorectal adenocarcinoma lesions (liver lesions only are considered as metastatic disease) and not resecable. * a single liver lesion may not exceed 3 cm * liver lesions must not have a depth greater than 2 cm from hepatic surface (glisson capsule) (measured clinically if possible otherwise on the basis of ct/ultrasound examination) * a life expectancy of at least 6 months. * patients with a ecog performance status \< 2 * signed informed consent * patient must be mentally capable of understanding the information given. * patient must give informed consent. exclusion criteria: * age less than 18 years. * patient pregnant or lactating (no contraceptive method is contraindicated, a pregnancy test will be administered to all women of childbearing age) * life-threatening infection and/or heart failure and/or liver failure and/or other severe systemic pathologies that preclude laparotomy * strumental analysis confirmed ascites. * impaired kidney function. * significant reduction in respiratory function. * allergic reaction to bleomycin. * coagulation disturbances * patients with exclusion criteria for diagnostic mri 3tesla (with pace-makers and all those metal devices that are not compatible with 3t).
treatment of breast fibroadenoma with high intensity focused ultrasound

Conditions: Breast Fibroadenoma

Summary: the purpose of this study is to test an investigational device called the echopulse for treatment of breast fibroadenomas in women. fibroadenomas are benign (noncancerous) breast tumors that are made of glandular and fibrous breast tissue. these lumps can occur alone, in groups, or as a complex of lumps together. sometimes women feel these in the breast when doing regular self breast exams, or they may be found during a routine mammogram. some are small (less than an inch in size), and others are quite large (the size of a lemon or larger). this is a study about the echopulse device, a computer driven system which uses ultrasound to guide a high intensity focused ultrasound beam to a targeted area (the fibroadenoma in the breast). the high intensity focused ultrasound (hifu) heats the targeted site which causes the cells to die and allows the possibility to treat the fibroadenoma without the need for surgery.


Eligibility criteria:
inclusion criteria: * diagnosis of fibroadenoma with histological confirmation of fibroadenoma of the breast * fibroadenoma is palpable * fibroadenoma is 1 cm or greater at its largest dimension and no less than 9 mm in the anterior-posterior dimension * fibroadenoma volume is between 2 cc and 10 cc * patient must give written informed consent (personally signed and dated) before completing any study-related procedure exclusion criteria: * patient is pregnant or nursing * patient with breast implants in the target breast * patient with a breast cyst within the fibroadenoma to be treated * patient participating in another clinical trial involving an investigational drug, device or biologic
formulation and efficacy of exercise prescription for patients with coronary heart disease

Conditions: Coronary Heart Disease

Summary: the purposes of this study is to standardize the process of formulating exercise prescriptions for coronary heart disease（chd）, verify the safety and effectiveness of exercise prescriptions, and establish a database of exercise prescriptions for chd, with a view to providing new solutions for cardiac rehabilitation.

this study conducted a comparative study on the therapeutic effect and safety of exercise prescriptions for patients with coronary heart disease with different risk stratifications. the purposes of this study is to standardize the process of formulating exercise prescriptions for coronary heart disease（chd）, verify the safety and effectiveness of exercise prescriptions, and establish a database of exercise prescriptions for chd, with a view to providing new solutions for cardiac rehabilitation.

Eligibility criteria:
inclusion criteria: * patients aged 18-80 years old with a diagnosis of coronary heart disease，nyha class i-iii hf patients. exclusion criteria: * acute myocardial infarction within 2 weeks * uncontrolled tachycardia (heart rate at rest \>120bpm * uncontrolled polypnea（breath rate at rest \>30 breath per minute * uncontrolled respiratory failure （spo2 ≤90%） * uncontrolled hyperglycemia (random blood glucose\>18mmol/l) * uncontrolled malignant arrhythmia with hemodynamic instability * uncontrolled septic shock and septicopyemia * uncooperation of the patients

Keywords: exercise prescription cardiac rehabilitation coronary heart disease
eastern caribbean health outcomes research network (echorn)

Conditions: Cancer; Cardiovascular Disease; Diabetes

Summary: the eastern caribbean health outcomes research network (echorn) is a collaborative research study that examines the lifestyles, eating habits, and health behaviors associated with cancer, diabetes and heart disease in adult men and women living in the eastern caribbean.

the eastern caribbean health outcomes research network (echorn) has two aims: (1) to form a research collaborative across the eastern caribbean islands of puerto rico, the u.s. virgin islands, barbados, and trinidad \& tobago to recruit and follow a community-dwelling adult cohort to estimate the prevalence of known and potential risk factors associated with the development of heart disease, cancer, and diabetes and (2) to enhance health outcomes research leadership capacity in the region through a series of dedicated activities locally and abroad. echorn will expand clinical research with racial/ethnic minority populations in a transitioning part of the globe now threatened with an epidemic of noncommunicable chronic diseases (ncd). echorn's findings will have direct implications for the health disparities research and policy agenda in the mainland united states. in the long term, the links echorn will facilitate with local health policy delegations and global strategic organizational partners will promote the translation of research to improve health outcomes across the region. the collection and storage of biological specimens will also contribute to national biomonitoring projects and has the potential to identify unique risk and protective factors in the development of ncd.

Eligibility criteria:
inclusion criteria: * greater than or equal to 40 years of age * english or spanish language speaking * resident of island at least 10 years * able to provide informed consent * non-institutionalized at the time of data collection * stable contact/residential information * no plans to relocate from island within the next 5 years

Keywords: cancer cardiovascular disease diabetes
early cycloergometric physiotherapy in critically ill patients with invasive mechanical ventilation

Conditions: Weakness

Summary: study designed to evaluate the functional and motor effects in critically ill subjects at icu and hospital discharge with the incorporation of a mobilization program of cycloergometric physiotherapy sessions compared with conventional physiotherapy.

cycloergometric treatment is described to improve the functional and motor status of critically ill subjects. however, there are few studies comparing cycloergometric physiotherapy and conventional physiotherapy in intensive care subjects under mechanical ventilation. the most relevant of these studies conducted by burtin et al showed beneficial effects of cycloergometric treatment. however, the duration of the physiotherapy sessions in this study differed between groups as cycloergometric group received a double daily dose of treatment. it is known that the intensity of physiotherapy also affects the functional and motor status. for this reason, the investigators designed a randomized controlled study with early cycloergometric or conventional treatment, with the same intensity between groups to analyze objective functional and motor endpoints.

Eligibility criteria:
inclusion criteria: * criteria of functional independence before hospital admission (barthel scale \> 70 points). * invasive mechanical ventilation \< 72 hours. * signed informed consent. exclusion criteria: * neuromuscular disease (peripheric or central neurologic disorder). * presumed fatal evolution in 48 hours. * conditions that impede pedaling movement (leg, pelvis or lumbar spinal surgery or traumatism). * admission due to cardiac arrest. * pregnancy. * thrombopenia less than 50.000. * severe agitation. * hemodynamic instability with noradrenaline requirements greater than 1 mcg/kg/min. * fraction of inspired oxygen (fio2) requirements greater that 0.55 and respiratory rate greater than 30 bpm.

Keywords: muscle weakness rehabilitation intensive care mechanical ventilation cyclo ergometer physiotherapy
ultrasonic treatment of food addiction

Conditions: Overweight; Obesity

Summary: this study will evaluate a new form of non-invasive deep brain therapy for food addiction. low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. a well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled trial. the trial will evaluate brain target engagement using magnetic resonance imaging, food cravings questionnaire-state, and changes in subject's weight over the course of the study.


Eligibility criteria:
inclusion criteria: * history of at least one self-reported unsuccessful dietary effort to lose body weight * body mass index more than or equal to 30 kg/m\^2 or more than or equal to 25 kg/m\^2 with the presence of at least one of the following weight-related comorbidities: hypertension, dyslipidaemia, obstructive sleep apnoea, or cardiovascular disease. exclusion criteria: * lifetime history of a serious suicide attempt * mri intolerance or contraindication * pregnant or breast feeding * diabetic (hba1c more than 48 mmol/mol or 6.5%) * a self-reported change in body weight more than 10 lbs within 60 days before screening * clinically inappropriate for participation in the study as determined by the study team
optimization of minocycline for helicobacter pylori rescue treatment

Conditions: Helicobacter Pylori Infection

Summary: the efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory h. pylori infection, though also accompanied with high occurrence of adverse events (55.4%). optimization of minocycline-based regimen to achieve high eradication rate with fewer adverse events is imperative. this study aimed to compare the efficacy and tolerability of a 14-day bismuth-containing quadruple rescue therapy with different dosage of minocycline and metronidazole compared to classical bismuth quadruple therapy.


Eligibility criteria:
inclusion criteria: * ability and willingness to participate in the study and to sign and give informed consent * confirmed h. pylori infection and with previous treatment experience exclusion criteria: * subjects naive to h. pylori treatment, * under 18 or over 80 years old * history of gastrectomy * pregnant or lactating women * previous history of tuberculosis * allergy to any of the study drugs * severe systemic diseases or malignancy * administration of antibiotics, bismuth, antisecretory drugs, or chinese herb medicine in the preceding 8 weeks

Keywords: helicobacter pylori rescue therapy minocycline tetracycline
comparison of cryotherapy and peeling agent in the treatment of common warts

Conditions: Warts

Summary: objective: to compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts. study design: randomized control trial. place and duration of study: department of dermatology, cmh abbottabad from jun 2022 to nov, 2022.

a total of 60 patients were enrolled in this investigation by non-probability consecutive sampling technique. sample size was calculated using who sample size calculator and patients were randomized into two equal groups, a and b, each comprising of 30 patients through lottery method. patients with common warts such as hard lesions, raised lumps with rough surfaces at the back of their fingers, around nails and palm of their hands between the ages of 18 and 60 were included, whereas those with genital warts, cardiac, hepatic, renal, or hypercholesterolemia were excluded.

Eligibility criteria:
inclusion criteria: * patient presented with common warts in dermatology opd exclusion criteria: * • patients with warts on toes and tip of fingers * genital warts * cardiac, hepatic and renal disease * hypercholesterolemia * hypersensitivity reactions
study to assess the clinical efficacy of the specialized enteral tube nutrition composition nutrison advanced cubison as a part of complex pressure ulcers (pu) therapy

Conditions: Pressure Ulcer ( Stage 2-3)

Summary: a large number of studies are devoted to studying the effect of patient nutrition on the occurrence and treatment of pressure ulcers. several studies, including the us national long-term treatment of pressure ulcers study, have shown that weight loss and malnutrition were associated with a higher risk of pressure ulcers. one of the successful products specially created for the treatment of pressure ulcers and taking into account the results of research is the high-protein, energy-rich, ready-to-use enteral tube feeding food product nutrison advanced cubison. it is a complete enteral nutritional supplement with an innovative nutrient composition for patients with chronic wounds, including pressure ulcers, or at increased risk of developing them. taking into account the available data, it seems expedient to continue studying the unique combination of nutrients that make up the study food product nutrison advanced cubison in order to develop the most effective nutritional protocols for patients at risk for the treatment and prevention of pressure ulcers.


Eligibility criteria:
inclusion criteria: * patients diagnosed with stroke / tbi and who are on tube feeding * presence of pressure ulcers of 2-3 stages * informed voluntary consent to medical intervention is formalized in accordance with the requirements of the federal law of 21.11.2011 n 323-fz "on the basics of protecting the health of citizens in the russian federation." exclusion criteria: * hemodynamically unstable patients * severe renal impairment (gfr \<30 ml / min) * moderate or severe liver failure (child-pugh class b or c) * oncological diseases (lasting more than 5 years) * hypersensitivity to any component of the test food mixture * inclusion in clinical interventional research * uncertainty of the investigator about the willingness or ability of the subject to comply with the protocol requirements * any other medical or non-medical reasons that, in the opinion of the physician, may prevent the patient from participating in the study

Keywords: stroke traumatic brain injury
the evolution and management of migraine recurrence beyond 24 hours

Conditions: Migraine

Summary: what is the course of migraine headache recurrence, how is it managed, what characteristics are associated with it, and how does it influence patient satisfaction with treatment?


Eligibility criteria:
inclusion criteria: * female and male patients at university headache center with \> 6 month diagnosis of migraine with and/or without aura (ichd-ii) * greater than or equal to 18 years old exclusion criteria: * greater than 15 days/month total headache days * analgesic use greater than 15 days/month (other than aspirin less than or equal to 325mg/d)
an analysis of treatment patterns and outcomes for basal cell carcinoma (bcc) cancer participants

Conditions: Basal Cell Carcinoma

Summary: this multi-center, observational study involves reviewing the medical records of approximately 100 adult participants diagnosed with advanced bcc from 01 january 2005 until 31 december 2010. participant records will be analyzed to identify participant characteristics, treatment patterns and clinical outcomes.


Eligibility criteria:
inclusion criteria: * new diagnosis of advanced bcc, defined as (1) locally advanced bcc (inoperable as determined by the site investigator or surgery contraindicated) with receipt of radiation therapy (unless radiation was contraindicated), or (2) metastatic bcc, from 01 january 2005 through 31 december 2010 exclusion criteria: * participation in an interventional trial that dictated treatment during the study time period (01 january 2005 - 31 december 2010), or within 90 days prior to individual participant' study enrolment dates * participants undergoing treatment with a hedgehog pathway inhibitor
condylar position changes in anterior disc displacement with reduction

Conditions: TMJ Disorder

Summary: the goal of this clinical trial is to know if tmj lavage does change the condyle position in patients diagnosed with unilateral anterior disc displacement with reduction. the main questions it aims to answer are: * is the condyle position in anterior disc displacement with reduction joints are the same in normal joints? * does tmj lavage will affect the condyle position, or affects the contralateral condyle position? researchers will compare condyle position in unilateral anterior disc displacement with reduction to the normal joint using cbct before and after lavage to see if any changes in position will occur in even side. participants will: make cbct for both condyles before lavage and after three months post lavage. visit clinic after two weeks, one month, and three months to evaluate the clinical data.


Eligibility criteria:
inclusion criteria: * • unilateral anterior disc displacement with reduction according to helkimo's clinical dysfunction index including (covert et al., 2021a).: 1. impaired range of movement. 2. impaired tmj dysfunction. 3. muscles pain. 4. tmj pain. exclusion criteria: * • bilateral anterior disc displacement with reduction. * previous fracture in tmj. * any pathological lesion in tmj. * congenital craniofacial anomalies. * any previous surgical procedure in tmj. * any medically compromised patient (mental deficiency, osteoporosis...) * previous arthrocentesis in tmj. * partial or complete edentulous patients. * any psychological patient.
the accuracy of manual bppv diagnostics when using vng goggles.

Conditions: Benign Paroxysmal Positional Vertigo; BPPV; Vertigo; Vestibular Disorder; Vestibular Diseases; Labyrinth Diseases; Inner Ear Disease

Summary: the aim is to investigate the accuracy of manual diagnostics of benign paroxysmal positional vertigo (bppv) by comparing it to bppv diagnostics in mechanical rotational chair (trv chair). vng (videonystagmography) goggles will be used in both scenarios. furthermore, the investigators will examine the importance of angulation and velocity in relation to the diagnostic outcome.

open-label, randomized controlled trial with cross over comparing manual bedside bppv diagnostics with diagnostics in a mechanical rotational chair (trv chair) when using vng goggles in both scenarios. patients with a history of positional vertigo will be considered for enrollment and randomized to which diagnostic modality they begin with. each subject will wait for minimum 30 minutes between the two diagnostics.

Eligibility criteria:
inclusion criteria: * age above 18 years * classic bppv-patient history (short lasting (\<1 minute) positional rotatory vertigo, no accompanying tinnitus or hearing loss, and no focal neurological findings. * understand written and spoken danish exclusion criteria: * pregnancy * weight ≥ 150 kg and or height ≥ 2m * neck and spine immobility to a degree where md on examination bed is impossible * insufficient cooperation during diagnostic testing * sedative antihistamines taken within the past seven days * comorbidities: heart failure (ef \< 40), known cerebral aneurysm, cerebrovascular events (\<3 months) or dissection disease * spontaneous or gaze evoked nystagmus

Keywords: trv reposition chair dix-hallpike maneuver supine roll test