stem cell transplant for immunologic or histiocytic disorders

Conditions: Hemophagocytic Lymphohistiocytosis; X-Linked Lymphoproliferative Disorders; Chediak-Higashi Syndrome; Griscelli Syndrome; Immunologic Deficiency Syndromes; Langerhans-Cell Histiocytosis

Summary: this study tests the clinical outcomes of a preparative regimen of fludarabine (flu), anti-thymocyte globulin (atg)/or campath, and melphalan; followed by hematopoietic stem cell transplant, and a post transplant regimen of cyclosporin a (csa) in patients with immunologic or histiocytic disorders. the researchers hypothesize that this regimen will have a positive effect on post transplant engraftment and the incidence of graft-versus-host-disease (gvhd). patients will be randomized biologically into one of 3 arms based upon donor availability: (a) human leukocyte antigen (hla) genotypic matched sibling donor, (b) hla phenotypic matched unrelated peripheral blood stem cell (pbsc) donor, (c) two hla 0-2 antigen mismatched unrelated cord blood donors (double cord).

prior to transplantation, subjects will receive melphalan, fludarabine and anti-thymocyte globulin (atg) or campath. these three drugs are being given to subjects to help the new stem cells take and grow. on the day of transplantation, subjects will receive stem cells transfused via intravenous (iv) catheter. after stem cell transplantation, subjects will be given cyclosporin a (csa) and mycophenolate mofetil (mmf) to reduce the risk of graft-versus-host disease, the complication that occurs when the donor's stem cells react against the patient.

Eligibility criteria:
inclusion criteria: patients with immunodeficiencies or histiocytic disorders 0-35 years of age with an acceptable stem cell donor and disease characteristic defined by the following: * patients with histocytic disorders (hemophagocytic lymphohistiocytosis of any etiology and refractory langerhans cell histiocytosis) who do not meet eligibility criteria for a myeloablative transplant procedure * patients with immunodeficiency disorders in whom residual immune function may not require a fully myeloablative preparative regimen or patient is ineligible for standard myeloablative preparative regimen (any form of severe combined immunodeficiency \[scid\], or other immunodeficiency with t cell defect) * patients with immunodeficiency disorders that have had poor outcome with myeloablative stem cell transplants (including, but not limited to, common variable immunodeficiency \[cvid\], wiskott aldrich syndrome \[was\] if \> 5 years of age, ataxia telangiectasia) * patients with immunodeficiencies or histocytic disorders that require a second stem cell transplant (sct) for any reason exclusion criteria: * karnofsky or lansky performance score \<70 * glomerular filtration rate (gfr)\<30% predicted * cardiac function \<50% normal by echocardiogram * serum creatinine \> 2x normal for age/weight * pregnant or lactating females * active serious infection that has not had an adequate course of therapy pre-sct. any patient with acquired immune deficiency syndrome (aids) or aids-related complex (arc) or human immunodeficiency virus (hiv) seropositivity

Keywords: stem cell transplant immunodeficiency donor lymphocyte infusion