Kornimate/medical-research-clean huggingface dataset:
the utility of mobile based application for patient reported outcome measures in patients with acetabular fractures : a randomized clinical trial

Conditions: Acetabular Fracture

Summary: the primary objective of this study is to validate the feasibility of a remote patient monitoring (rpm) system using mobile app in terms of the frequency of data interruptions and patient acceptance. the secondary objective is to improve quality of life and early prediction of the complications.

acetabular fractures are articular fractures involving the hip joint that needs anatomical reduction and a strict long follow up after fixation. the percentage of patients with lost follow up is significantly high. previously all other studies mainly focused on the radiographic outcome after acetabular fractures and rarely on patient reported functional outcomes and quality of life.the use of patient-reported outcome measures (proms) is increasing and may lead to modifications of treatment. recent technologic advances, namely smartphones, capable of measuring outcomes after acetabular fractures are now very important in quantifying value-based care. this was previously accomplished through office assessments and surveys with variable follow-up, but this strategy lacks continuous and complete data. studies show that these remote modes of follow-up are safe and that patients are as equally satisfied with them as they are with in-person follow- up care.

Eligibility criteria:
inclusion criteria: * all patients aged more than 18 years who will have a surgery for an acetabular fracture at assiut university hospital. exclusion criteria: * patients younger than 18years old
impact of the respiratory isolation on the quality of life in patients hospitalized for tuberculosis or covid-19

Conditions: Tuberculosis; Covid19

Summary: the respiratory isolation could have a harmful impact on the well-being of patients, especially in a psychological point of view such as anxiety and depression disorders or through the relationship with medical team and/or relatives but also in terms of informations. the evaluation of the impact of respiratory isolation in patients hospitalized for tuberculosis or covid-19 could allow to identify the different kinds of problems encountered by these patients (physical, psychological, sociological, informations, ...) in order to adapt the environment for efficient care and to improve patient's well-being. the purpose of this research is to evaluate the psychological impact of the respiratory isolation on the quality of life in patients hospitalized for tuberculosis or covid-19.


Eligibility criteria:
inclusion criteria: 1. patient who are more than 18 years old hospitalized in respiratory isolation for tuberculosis or covid-19. 2. patient able to understand questions and to communicate verbally with investigators. 3. patient who has given his consent. exclusion criteria: 1. patient deprived of their rights 2. patient under tutorship or guardianship or under the protection of a conservator 3. tuberculosis without respiratory isolation
a study of ly900014 in participants with type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of this study is to compare ly900014 with insulin lispro (humalog) in participants with type 1 diabetes mellitus. there are 2 parts to this study. part a is investigating how the body processes ly900014 and the effect of ly900014 on blood sugar levels compared to insulin lispro (humalog) when study treatment is given by subcutaneous injection. part b of the study is investigating how the body processes ly900014 and the effect of ly900014 on blood sugar levels compared to insulin lispro (humalog) when study treatment is given by continuous subcutaneous insulin infusion (csii) pump. screening is required within 28 days prior to the start of the study. for each participant, the study will last about 40 days in each part.


Eligibility criteria:
inclusion criteria: * are male or female participants aged 6-64 with type 1 diabetes mellitus (t1dm) for at least 1 year * have a glycated hemoglobin (hba1c) less than (\<)10.0 percent (%) exclusion criteria: * receiving any oral or injectable medication intended for the treatment of diabetes mellitus other than insulins in the 12 months prior to screening * more than one episode of severe hypoglycaemia in the last 6 months * presence of clinically significant hematologic, oncologic, renal, cardiac, hepatic, or gastrointestinal disease, proliferative retinopathy, uncontrolled celiac disease, uncontrolled hyperthyroidism or hypothyroidism, or adrenal insufficiency * have obvious clinical signs or symptoms of liver disease * have a history of renal impairment
allis clamp versus single-tooth tenaculum

Conditions: IUD

Summary: this study aims to determine whether an allis clamp is an effective clamp for cervical stabilization compared to a single-tooth tenaculum.


Eligibility criteria:
inclusion criteria: * obtaining iud exclusion criteria: -

Keywords: cervical stabilization
effect of exercise therapy on type ii diabetic neuropathic patients

Conditions: Diabetic Nephropathy Type 2

Summary: the goal of this randomized control trial (clinical trial) is to learn about the effect of exercise therapy on type ii diabetic neuropathic patient in pakistan ,40-70 year's old patient, will be refer by physicians. exclusion criteria of the study will lower extremity complications such as fracture, having experience dislocation at least six months prior to the study, having any history of surgical operations in muscles, bones, and joints of lower extremities, suffering from musculoskeletal disorders such as rheumatoid arthritis and myopathy, middle ear and vestibular impairments (patients' self-report), knee joint flexion contracture, and interruption of the intervention sessions for more than two days.. the main question it aims to answer are: 1. to compare the effects of two therapeutic exercises on clinical balance measures on type ii diabetic peripheral neuropathy patients. 2. effectiveness of exercises using swiss ball in lowering bmi. 3. to assess the effectiveness of exercise interventions on fasting blood sugar (fbs) levels and glycosylated hemoglobin (hba1c) in individuals with type ii diabetes. 4. to evaluate the effectiveness of exercise interventions on autonomic nervous system activity in patients with type ii diabetic peripheral neuropathy. 5. to assess the comparative effectiveness of two therapeutic exercise interventions and a control group in improving the michigan neuropathy screening instrument (mnsi) score. by using random allocation, the participants will divided into three groups: an intervention group (n=30) that receive ball training exercise, another intervention group (n=30) that receive frenkel training exercise and a control group (n=30). each exercise session contain 5 min warm-up (stationary bike), 45 min exercise training (with 1 minute rest for every 5 minutes of exercise), and 5 min of cool down activities including stretching of the muscles involved in balance exercise (gluteal, erector spine, hamstring, rectus femorus, gastro soleus, and pectoral muscles). this make the participants' heart rate stable and prepare their muscles for optimal activity.


Eligibility criteria:
inclusion criteria: * patients with type ii diabetic neuropathy * 40-70 year's old patient, will be refer by physicians. exclusion criteria: * lower extremity complications fracture * having experience dislocation at least six months prior to the study * having any history of surgical operations in muscles, bones, and joints of lower extremities, * suffering from musculoskeletal disorders such as rheumatoid arthritis and myopathy, middle ear and vestibular impairments (patients' self-report) * knee joint flexion contracture * interruption of the intervention sessions for more than two days

Keywords: exercise therapy diabetic neuropathies type 2 diabetes mellitus michigan neuropathy screening instrument
l1 m1 of ldct for low muscle mass measurement

Conditions: Sarcopenia

Summary: the first lumbar spine muscle index (l1 mi) on computed tomography (ct) obtained by measuring muscle surface at the first lumbar vertebrae (l1) level is an indicator of total skeletal mass in specific populations. nevertheless, the utility of l1 mi derived from low dose chest ct (ldct) in health assessments and relevant cutoff points are unclear.


Eligibility criteria:
inclusion criteria: * adults older than 20 years who received ldct in routine health assessments from january to december 2017 were enrolled at a tertiary care hospital (far eastern memorial hospital, new taipei city, taiwan). exclusion criteria: * nil
speech therapy and functional dysphonia after thyroidectomy

Conditions: Functional Dysphonia

Summary: following a thyroidectomy, voice and swallowing alterations, which more frequently would appear to be caused by lesions of the laryngeal nerve, may occur. but, voice and swallowing changes can also occur in the absence of lesions of the inferior laryngeal nerve or the external branch of the superior laryngeal nerve, defining a condition called central compartment syndrome or functional post-thyroidectomy syndrome. it has been demonstrated that, in the presence of the aforementioned syndrome, the quality of the voice undergoes a deterioration immediately after thyroidectomy surgery with a lowering of pitch. the purpose of this study will be to verify the effects of early speech therapy, including pre-operative speech therapy counseling (during which the patient will be provided with indications to be implemented in the immediate post-operative period).


Eligibility criteria:
inclusion criteria: * awaiting total thyroidectomy surgery * able to sign a written consent exclusion criteria: * under the age of 21 or over the age of 65 * previous vocal cord paralysis * history of vocal or laryngeal pathologies that have required therapy * presence of speech disorders or lung pathologies * previous neck surgery * presence of malignant diseases
motor activity and its barriers at the early phase post-stroke in acute care setting.

Conditions: Stroke

Summary: being active early after stroke prevents secondary complications, reduces hospital length of stay and improves long-term functional outcomes. early mobilization and early rehabilitation are the means to achieve activity at the early phase post-stroke. performance of out-of-bed activity at an acute care setting is partially dependent on the routines used in the acute care setting, however, knowledge the knowledge about associations between clinical routines and the characteristics of out-of-bed activity is limited. also, there is limited knowledge about institutional barriers to such activity. accordingly, the goal of the current study is, in acute hospital inpatient setting, to: 1) characterize stroke patients' activity according to shifts (i.e. morning and evening), 2) test associations between out-of-bed activity and patients' clinical status and 3) identify barriers to activity. the study is a prospective observational study that monitors physical activity in people after stroke while they in an acute stroke care setting, and records berries for out-of-bed activity including being in sitting or standing and walking. patients are included if they admitted to the hospital within 48 hours of symptom onset, passed routine initial neurologic and nursing examinations within 48 hours of admission, and have score of 5-18 on the national institutes of health stroke scale (nihss). patients are excluded if they had hemorrhagic stroke, and if they have heart failure, acute coronary syndrome, unstable hemodynamics and fractures, or if they are terminally ill.

not required

Eligibility criteria:
inclusion criteria: * ischemic stroke * admitted to the hospital within 48 hours of symptom onset * passed routine initial neurologic and nursing examinations within 48 hours of admission * score of 5-18 on the national institutes of health stroke scale (nihss). exclusion criteria: * hemorrhagic stroke * heart failure * unstable hemodynamics * fractures * terminally ill
safety and efficacy of the bi-aspheric monofocal iol

Conditions: Cataract

Summary: this is an observational, single-center, non-control, open-label post-marketing study. patients implanted with an aspicio™ monofocal intraocular lens will be scheduled for a follow-up visit at least 3 months after the surgery to undergo a routine basic ophthalmological examination.

this is an observational, single-center, non-control, open-label post-marketing study. patients implanted with an aspicio™ monofocal intraocular lens will be scheduled for a single visit in the facilities of chang gung university hospital at least 3 months after the surgery. patients will undergo a routine basic ophthalmological examination. additionally, and retrospectively, the patients' medical records will be reviewed to obtain information on visual acuity and adverse events at postoperative visit carried out 1 month after surgery. the data corresponding to the preoperative values of corneal curvature (flat meridian, curved meridian and axes), axial length measured by biometry, visual acuity and those corresponding to the implanted iol will also be collected from the medical records.

Eligibility criteria:
inclusion criteria: 1. subjects 18 years of age or older who have been implanted with aspicio™ monofocal intraocular lens in at least 1 eye 2. willingness to cooperate with and complete all post-operative visits 3. ability to comprehend and sign an informed consent exclusion criteria: 1. any pathology that could reduce visual acuity (va) (including amblyopia, severe corneal dystrophy, diabetic retinopathy, extremely narrow anterior chamber depth, microphthalmos, clinically significant macular/rpe changes, retinal detachment, corneal transplant, chronic sever uveitis, choroidal hemorrhage, recurrent severe inflammation of the anterior or posterior segment of unknown etiology, iris neovascularization, medically controlled or uncontrolled glaucoma, clinically significant macular degeneration, or diagnosis of pseudoexfoliation). 2. previous ocular surgery (including yag-laser) or trauma 3. clinically significant irregular astigmatism 4. concomitant severe eye disease 5. pregnant or lactating 6. any other ocular or systemic condition which, in the opinion of the investigator, should exclude the subject from the study 7. concurrent participation in another drug or device investigation 8. may be expected to require other ocular surgery during the study

Keywords: cataract monofocal intraocular lens preloaded aphakic asqelio aspicio ast products icares
patient treatment analysis: hospital and wide-ranging out-of-hospital care assessment yields insights into heart failure outcomes

Conditions: Heart Failure

Summary: this is a monocentric cohort study conducted in the cardiology department of nancy hospital. the main purpose of the study is to document the global management strategy of patients hospitalized for heart failure and evaluate the association between patient's care and post-hospitalization outcome.


Eligibility criteria:
inclusion criteria: * man or women ≥ 18 years * patients hospitalized for cardiac decompensation (esc 2016 and 2021 criteria) exclusion criteria: * patient expressing refusal to participate in research * patient who is a minor or under administrative protection * pregnant women * patient with ventricular assistance * patient with congenital heart disease
imrt vs 2drt for npc patients

Conditions: NPC

Summary: irradiation of the parotid gland with subsequent long-term xerostomia is a well-recognized complication after radiotherapy for head and neck (han) cancers. a number of studies have shown that imrt could minimize the radiation dose to the parotid glands and hence the risk of developing xerostomia. the benefit of imrt has also been demonstrated in prior dosimetric and non-randomized studies in npc patients. in 2007, the investigators have published the prospective randomized study of imrt versus 2drt in early stage npc patients. in the study, imrt had lower incidence of observer-rated severe xerostomia, higher parotid and whole saliva flow rate, than patients in 2drt arm at 1 year after treatment. however, there was no significant difference in patient-reported outcome, i.e. subjective xerostomia scoring, between the 2 arms. the underlying reason for the incoherent findings in terms of objective and subjective xerostomia outcome remains uncertain. one of the possible explanations for this observation could be the better parotidsparing with imrt alone may not entirely sufficient to maintain oral cavity lubrication while the other mucin-secretory salivary gland protection is also essential. another possible explanation for the insignificant improvement in patient-reported outcome with imrt is the short follow-up time. gradual recovery or improvement in various quality of life parameters was not uncommonly seen several years after definitive radiotherapy for han cancer patients. there is much interest in studying the long term clinical outcome, especially the treatment-related complications, for the patients who had randomized and treated in the prior presented prospective study. in this study, the long term results, in particular the xerostomia rating will be assessed and compared in npc patients who had participated in the prior reported prospective randomized study of imrt vs 2drt.


Eligibility criteria:
inclusion criteria: * the npc patient, who had been enrolled, randomized and treated in the prior prospective randomized study of imrt vs 2drt. * regular follow-up for more than five years from the end of study intervention (i.e. imrt or 2drt for npc). * patient is able to sign the study-specific informed consent. * ecog performance status 0 or 1. * patient is able to complete the study's questionnaire. exclusion criteria: * npc patients who had not been randomized or allocated to the study intervention, even though had been enrolled in the prior reported study. * loss of regular follow-up from the end of study intervention. * regular follow-up for less than five years from the end of study intervention. * patients with known recurrent or metastatic disease. * patients with secondary malignancy occurred after completion of the previous study's treatment (i.e. radiotherapy). * active untreated infections * major medical or psychiatric illness
a study of channeling in the use of nonprescription paracetamol and ibuprofen in an electronic medical records database: evidence and implications

Conditions: Hemorrhage, Gastrointestinal; Myocardial Infarction; Stroke; Kidney Diseases

Summary: the purpose of this study is to examine whether evidence of channeling exists by analyzing within a cohort of participants with first prescriptions of single-ingredient paracetamol or ibuprofen (or both) whether participants with paracetamol were more likely to have an ibuprofen-related contraindication.


Eligibility criteria:
inclusion criteria: * enrolled in up-to-standard practices (practices that have been qualified for research purposes by the clinical practice research datalink \[cprd\] administrators) in the cprd * received a first prescription for paracetamol or a first prescription for ibuprofen in 2012 * were age 18 or older in the date of their qualifying prescription in 2012 exclusion criteria: * who received a prescription for paracetamol or ibuprofen in the 6 months prior to their qualifying prescription in 2012 * who received a prescription for any acetaminophen- or ibuprofen-containing combination products in the 6 months prior to the qualifying prescription in 2012
night driving pilot

Conditions: Cataract

Summary: pilot study to evaluate usability of mesotest ii for assessment of night driving capacity of pseudo-phakic patients implanted with aspheric monofocal posterior chamber iol \*at.smart 46lc. target criterion: measurement of contrast sensitivity and sensitivity to light under mesopic conditions (mesotest ii, oculus).


Eligibility criteria:
inclusion criteria: * healthy eyes with cataract * patient age 50-75 years * written patient informed consent * assured follow-up examination exclusion criteria: * any kind of macula degeneration and impairment of retina (clinical diagnosis) * amblyopia * intraoperative complications; damaged posterior bag; intraocular haemorrhage * astigmatism \> 1.5 d (objective, preoperative) * pregnancy or lactation period for female patients

Keywords: cataract intraocular lens (iol) mesotest ii evaluation of usability of mesotest ii for assessment of night driving capacity of pseudo-phakic patients
phase i study of alferon n injection in persons with asymptomatic human immunodeficiency virus (hiv) infection

Conditions: HIV Infections

Summary: to determine the safety and tolerance of subcutaneous injections of natural interferon alpha (ifn) in asymptomatic hiv-positive persons and record its effects on the hiv virus in these individuals.


Eligibility criteria:
inclusion criteria patients must have: * hiv-1 seropositivity. * cd4 count \> 400/mm3. * eligibility for care in the military medical system. prior medication: allowed: * acyclovir. exclusion criteria co-existing condition: patients with the following symptoms or conditions are excluded: * aids- or arc-defining condition (unexplained weight loss, fever, diarrhea, night sweats). * evidence of aids dementia. * chronic hepatitis with severe liver dysfunction. * active gastrointestinal, renal, respiratory, endocrine, hematologic, cardiovascular, or psychiatric disorder that would limit ability to complete the study. * hemophilia. * co-existent disease likely to result in death within the next 2 years. * known hypersensitivity to human interferon alpha. * known anaphylactic hypersensitivity to mouse immunoglobulin (igg), egg protein, or neomycin. concurrent medication: excluded: * any other concurrent experimental medications. patients with the following prior conditions are excluded: * history of aids- or arc-defining condition (unexplained weight loss, fever, diarrhea, night sweats). * evidence of chronic hepatitis with severe liver dysfunction. prior medication: excluded within 5 days prior to study entry: * immunosuppressive agents. * chemotherapy. * steroids. excluded within 45 days prior to study entry: * bcg vaccine. * isoprinosine. * other immune modulators. excluded within 3 months prior to study entry: * any form of interferon. * antiviral therapy. * immunoregulatory therapy (other than acyclovir). 1. active drug abuse (narcotic or alcohol abuse documented within the past 6 months). * unlikely or unable to comply with the requirements of the protocol.

Keywords: drug evaluation interferon-alpha