Kornimate/medical-research-clean huggingface dataset:
sleep architecture and factors associated with definitive diagnosis of sleep bruxism

Conditions: Sleep Bruxism, Adult

Summary: this case-control study will evaluates the association between the definitive sleep bruxism diagnosis by gold-standard polysomnography examination obtained at pelotas sleep institute and the sociodemographic, occupational, clinical conditions, sleep quality, sleep structure and epworth sleepiness scale variables.

currently, as sleep and awake bruxism are generally considered as different behaviours observed during sleep and wakefulness, respectively, the single definition for bruxism is recommended be "retired" in favour of 2 separate definitions. in this sense, the sleep bruxism is a masticatory muscle activity during sleep that is characterised as rhythmic (phasic) or non-rhythmic (tonic) and is not a movement disorder or a sleep disorder in otherwise healthy individuals .the diagnosis of sleep bruxism often is challenging and despite the use of questionnaires, clinical exams and portable devices, based on current knowledge, the polysomnography with audio-video recordings emerges as the gold-standard criteria for a definite sleep bruxism diagnosis. included on the questionnaire there is a registration form, which contains: sociodemographic: self-reported ethnicity, marital status, education level; occupational: individuals were asked about work outside home, working hours; clinical condition: body mass index, smoking; alcohol consumption; use of sleeping pills. sleep quality, was evaluated with the following questions: sleep behavioral, how long does it take to sleep; restless sleep; nightmares; heartburn, obstructive sleep apnea by polysomnography. bedtime, sleep time. waking during the night, insomnia. morning wake up, headache on waking; lastly, sleep structure data: sleep onset latency, rapid eye movement, sleep latency, wake time after sleep onset, total sleep time, sleep efficiency, non-rapid eye movement, sleep time in stages n1, n2, and n3, rem sleep time, arousal, arousal per hour, respiratory disturbance index, apnea-hypopnea index; and epworth sleepiness scale.

Eligibility criteria:
inclusion criteria: * adults (aged 20 to 60 years) and elderly (aged \> 60 years) (who-world health organization, 2015) who were undergone to polysomnography (psg) at the pelotas sleep institute (psi); * adequate cognitive capacity to understand and answer the questionnaire. exclusion criteria: • those which the participants were unable to answer the questionnaires and who presented a history of epilepsy that could interfere in the results of psg.

Keywords: diagnostic polysomnography sleep architecture sleep bruxism
xenogenous collagen matrix graft with or without enamel matrix proteins derivative for root coverage

Conditions: Gingival Recession

Summary: the purpose of this study is to evaluate the reduction of gingival recession of single miller class i and ii defects treated by coronally advanced flap with subepithelial porcine collagen matrix graft and / or enamel matrix proteins.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * presence of at least one class i or ii miller gingival recession ≥ 2.5 mm in maxillary canines or premolars with identifiable cementum-enamel junction (cej) and without deep non-carious cervical lesions (\< 0.5 mm): a +(pini-prato et al. 2010). * aesthetic complaint and/or presence of dentin hypersensitivity to air stimulus. * full-mouth visible plaque index ≤ 20% (ainamo \& bay 1975). * full-mouth sulcus bleeding index ≤ 20% (mühlemann \& son 1971). exclusion criteria: * smoking. * pregnancy. * presence of systemic disorders (diabetes, hypertension, heart disease or any other condition that could contraindicate periodontal surgery). * use of medications (immunosuppressants, phenytoin or anything else that might affect mucosal healing and repair). * previous periodontal surgery in the area.

Keywords: gingival recession coronally advanced flap periodontal regeneration
evaluate the effectiveness and toxicity of adjuvant ultra-hypofractionated radiotherapy for breast cancer

Conditions: Breast Cancer Female

Summary: prospective phase 2 study to evaluate the safety and efficacy of ultra-hypofractionated adjuvant radiotherapy in 5 fractions of 5.7 gy in patients aged over 65 years.

prospective phase 2 non-randomized single-arm study to evaluate the safety and efficacy of ultra-hypofractionated adjuvant radiotherapy in 5 fractions of 5.7 gy in patients aged over 65 years.

Eligibility criteria:
inclusion criteria: 1. female patient; 2. pathological confirmation of invasive breast carcinoma regardless of histological subtype and hormonal profile; 3. age greater than or equal to 65 years; 4. breast-conserving surgery or mastectomy with or without axillary approach 5. with or without neoadjuvant or adjuvant systemic treatment exclusion criteria: 1. patients with previous thoracic irradiation; 2. patients with indication for bilateral thoracic irradiation; 3. patients with breast reconstruction with prosthesis or autologous tissue; 4. patients with compromised surgical margins after resection; 5. pt1-pt2 pn0 patients undergoing radical mastectomy.

Keywords: breast cancer adjuvant radiotherapy ultra-hypofractionated
pharmacist follow-up, a qualitative study of patient experience

Conditions: Patient Satisfaction; Patient Preference

Summary: a pharmacist follow-up procedure is under development. patients with coronary heart disease (chd) is being followed up by a pharmacist for one year with three meetings; at discharge from hospital, after three months and after one year. the evaluation is basically based on quantitative measures as achievement of therapeutic goals, number of drug related problems detected, hospitalisations etc. however, the patients' own experience with the follow-up procedure cannot be evaluated using these measures. thus, a qualitative approach is needed. in this study, a total of four patients participating in the follow-up will be included and interviewed. a semistructured interview guide will be used. interviews will be taped, transcribed and analyzed with the intention to explore how patients experience the follow-up from the pharmacist. a thoruough content analysis will be performed. patients included must have met the pharmacist at least twice. the pharmacist in charge of the follow-up will recruit patients and hand out study information. patients will reply to the principal investigator of the study and thus kept anonymous for the pharmacist in charge of the follow-up. no pressure will be put on the patients to join, but it will be emphasized that it will help evaluating the procedure.

see full publication on http://www.biomedcentral.com/1756-0500/7/197 garcia et al. bmc research notes 2014, 7:197

Eligibility criteria:
inclusion criteria: * must have met the pharmacist at least twice * living within the area of tromsoe city so that interviews are possible exclusion criteria * none as patients are already enrolled in another study

Keywords: qualitetive interview coronary heart disease (chd) patient experience patient perception
differences in the presentation outcome and response to treatment between never- smokers and smokers with nsclc

Conditions: Smokers

Summary: we wish to discover if there is a difference in the presentation, response to treatment and survival of never- smokers with lung cancer as compared to ever- smokers. we also plan to obtain tumor specimens to compare the genetic and proteomic expression between smokers and never smokers

lung cancer is the most lethal of all malignant tumors affecting humans. in the united states alone an estimated 160,440 patients died of lung cancer 2004\[1\]. it is well known that tobacco smoking is a major risk factor and accounts for the majority of all lung cancer cases. but there is a sub group of patients with lung cancer who have never actively smoked tobacco. this group exhibits certain unique characteristics which separates them from lung cancer in smokers. it has been shown that never- smokers with adenocarcinoma have better outcomes in terms of overall survival as well as lung cancer specific survival when compared to current smokers with adenocarcinoma of the lung\[2\]. also patients who are current smokers at diagnosis have decreased survival when compared to people who quit smoking\[3\]. the improved survival in never smokers could be due to several reasons. such as increased incidence of co-morbid factors in smokers as result of exposure to tobacco smoke, differences in metabolism of chemotherapeutic agents or a reflection of differences in the underlying molecular biology of the tumor. it has been demonstrated that chromosomal abnormalities are common in lung cancer patients with a smoking history when compared to never- smokers\[4\]. gene mutations such as p53 mutations are more frequent in never- smokers than in previous smokers\[5\]. in addition mutations that are specific only to lung cancer in never smokers have been discovered, demonstrating the possibility of a separate or overlapping carcinogenesis pathway for lung cancer in never smokers vs. smokers \[6\].

Eligibility criteria:
inclusion criteria: * age range 18-88, diagnosed with non- small cell lung cancer between jan 1 1996 and dec 31 2002. exclusion criteria: * patients diagnosed prior to dec 31, 1995 and after jan 1, 2003

Keywords: presentation outcome response never- smokers
hope in action prospective multicenter, clinical trial of deceased hivd+ kidney transplants for hiv+ recipients

Conditions: Hiv

Summary: the primary objective of this study is to determine if an hiv-infected deceased kidney donor (hivd+) transplant is safe with regards to major transplant-related and hiv-related complications.

this study will evaluate if receiving a kidney transplant from an hiv-infected deceased kidney donor is safe with regards to survival and major transplant-related and hiv-related complications compared to receiving a kidney from an hiv-uninfected deceased kidney donor (hivd-). those participants who have accepted an hivd- organ will be randomized to be followed in the full study or followed in the nested observational group.

Eligibility criteria:
inclusion criteria: * participant meets the standard criteria for kidney transplant at the local center. * participant is able to understand and provide informed consent. * participant meets with an independent advocate per the hiv organ policy equity (hope) act safeguards. * documented hiv infection (by any licensed assay, or documented history of detectable hiv-1 rna). * participant is ≥18 years old. * opportunistic complications: if prior history of an opportunistic infection, the participant has received appropriate therapy and has no evidence of active disease. * cluster of differentiation 4 (cd4)+ t-cell: ≥200/µl within 16 weeks of transplant. * hiv-1 is below 50 copies rna/ml. viral blips between 50-400 copies allowed as long as there are not consecutive measurements \>200 copies/ml. * participant is willing to comply with all medication related to their transplant and hiv management. * for participant with a history of aspergillus colonization or disease, no evidence of active disease. * the participant must have, or be willing to start seeing, a primary medical care provider with expertise in hiv management. * all participants participating in sexual activity that could lead to pregnancy must use an fda approved method of birth control. * participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to hiv disease. exclusion criteria: * participant has a history of progressive multifocal leukoencephalopathy (pml) or primary central nervous system (cns) lymphoma. * participant is pregnant or breastfeeding. * past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks or may impact the quality or interpretation of the data obtained from the study.
nicu asthma education and secondhand smoke reduction study

Conditions: Respiratory Illness

Summary: premature infants have a significantly increased risk for developing respiratory illnesses and asthma. secondhand smoke (shs) also is clearly associated with increased breathing problems in children, thus exposure to smoke makes it substantially more likely for a premature infant to develop wheezing. the overall goal of this study is to test whether comprehensive asthma education combined with a home-based secondhand smoke reduction program can reduce exposure to smoke and prevent respiratory illness among premature infants. our hypotheses are: * more premature infants whose families receive asthma education combined with a shs reduction intervention will live in smoke-free environments compared to infants receiving only asthma education (control group). * caregivers receiving the shs reduction program will have higher rates of quit attempts and less relapse into smoking compared to caregivers in the control group. * infants whose families receive the combined intervention will experience less respiratory illness compared to infants in the control group.


Eligibility criteria:
inclusion criteria: * ≤32 weeks gestation * planned discharge to home from the neonatal intensive care unit * parent or caregiver must consent to the intervention * the first sibling discharged, for twins or infants from a multiple birth pregnancy exclusion criteria: * inability to speak and understand english * no access to a working phone for follow-up surveys (either at the subject's home or an easily accessible alternate home) * family residence outside the greater rochester area (more than 30 miles away) * children in foster care or other situations in which guardian consent cannot be obtained * the child having significant medical conditions, including serious heart disease, cystic fibrosis, or other conditions that could interfere with the assessment of respiratory-related outcome measures
community intervention for minority children with asthma

Conditions: Asthma; Lung Diseases

Summary: to test the effectiveness of school-based asthma education interventions, community-based asthma health workers' programs and the combination of these on asthmatic children. also, to examine the separate and combined impact of asthma interventions designed to address problems associated with effective asthma self-management amd difficulties in establishing and maintaining continuity of medical care.

background: asthma is a leading cause of childhood illness that disproportionately affects minority children. the causes of higher hospitalization and death rates among minority children with asthma are not understood. it is commonly assumed that barriers related to poverty underlie this public health issue. two proposed causes of this increased morbidity and mortality are problems associated with effective asthma self-management and difficulties in establishing and maintaining continuity of medical care. the study was part of a demonstration and education initiative "interventions for control of asthma among black and hispanic children" which was released by the nhlbi in june 1989. design narrative: a school-based asthma self-management program was developed to promote children's self-management skills within predominately minority schools. a community-based asthma health worker program was developed to assist minority families in establishing and maintaining asthma health care within the community. it was hypothesized that the most effective control of asthma would be achieved with the combination of these two interventions. twenty elementary schools each in inner-city baltimore, maryland and inner-city washington d.c. served as study sites. asthmatic children grades 1-5 were identified by school records and parent surveys. after obtaining consent, schools were randomly assigned to one of four intervention groups: 1) a control/minimal intervention, 2) a school-based asthma education program, 3) a community-based asthma health worker program, and 4) a combined intervention that included both the school-based education program and the community-based health worker program. the duration of both the school program and the community health worker program was twelve months. baseline measures were collected after obtaining consent and prior to school randomization. followup measures were collected from children and families at 6, 12, 18, and 24 months. data were collected on hospitalization, emergency or urgent care, acute episodes, health care utilization, medications, school absences, academic performance, self-esteem, self and family asthma management, and family coping. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
spectroscopy with surface coils and decoupling

Conditions: Adrenal Cortical Cancer; Brain Cancer; Breast Cancer; CNS Cancer; Colon Cancer; HEENT Cancer; Hodgkin's Disease; Kaposi's Sarcoma; Liver Cancer; Lung Cancer; Non-Hodgkin's Lymphoma; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Rectal Cancer; Renal Cancer; Sarcoma; Squamous Cell Carcinoma; Thyroid Cancer

Summary: the purpose of this study is to obtain chemical information from part of your body without a biopsy. this is done using a technique called magnetic resonance spectroscopy (mrs) which is similar to magnetic resonance imaging (mri) except that signals are detected from the chemicals (spectroscopy) naturally present in your body using radio waves. to receive this information from your body, small loops of wire (surface coils), placed near the tissue of interest, may be used to more effectively detect signals that come from the chemicals in your body. the investigators may use a second radio channel simultaneously, which will allow us to obtain greater chemical information (decoupling). the results may also help us to understand how this study can be used to help other patients with your condition.

the investigators propose to use 1h spectroscopy or 1h decoupled 31p nmr spectroscopy to obtain biochemical information about tumor metabolism in patients, both before and after antineoplastic therapy. in healthy volunteers, normal tissue metabolism will also be studied. it is hypothesized that metabolic information may be of prognostic significance, or may be useful for timing of therapy.

Eligibility criteria:
inclusion criteria: * patients must have suspected or documented neoplastic disease, strongly suspected or established by physical examination, history or conventional histologic biochemical or imaging techniques, or have surgical or aspiration biopsy that will be used to establish a diagnosis * patients with obstructive jaundice, both from malignant and non-malignant disease, will be considered for the study * patients/volunteers must be clinically stable and not require cardiovascular monitoring * patients must be 6 years of age or older and be able to cooperate for an approximately 60 minute examination * volunteers must be 18 years of age or older exclusion criteria: * inability to cooperate for an mr exam * contraindication to mr: pacemaker, aneurysmal clips any ferrous metallic implants which could be deflected by the magnet, metal implants in field of view, pregnant women, or age and mental status wherein he/she is unable to cooperate for mr study
study of blood flow changes and microemboli during carotid surgery

Conditions: Carotid Endarterectomy; Percutaneous Transluminal Angioplasty; Cognitive Aspects; Diffusion Weighted MRI

Summary: the purpose of this study is to determine the clinical and radiologic implications of the intraoperative microemboli during carotid revascularization.


Eligibility criteria:
inclusion criteria: * acoustic window for transcranial doppler * surgical criteria proposed by the nascet and acas studies * postoperative follow-up for at least six months * patient consent exclusion criteria: * carotid restenosis * combined surgery * emergency surgery
written versus verbal education for mild traumatic brain injury

Conditions: Mild Traumatic Brain Injury

Summary: mild traumatic brain injury (mtbi) is a common injury that involves loss of consciousness or alteration in mental status induced by an external mechanical force to the head. education about symptoms and reassurance of a prompt recovery usually results in full recovery. however, a subgroup appears to have persistent symptoms and disability. this study will recruit mtbi patients from two emergency departments with the aim of identifying modifiable patient characteristics that can delay or prevent full recovery. a secondary aim is to determine if providing education in writing or in-person makes a difference.


Eligibility criteria:
inclusion criteria: * confirmation of a likely concussion without hospital admission * participants live locally with a fixed address * participants experience at least one new symptom exclusion criteria: * participants who cannot understand/read english
effects of compression stockings on obstructive sleep apnea in patients under hemodialysis

Conditions: Renal Failure Chronic Requiring Dialysis; Obstructive Sleep Apnea

Summary: to study the effects of compression stockings on sleep apnea in hemodialysis patients with diagnosed obstructive sleep apnea. the rationale of this study consists in the fluid shift theory, which consists in the nocturnal rostral fluid shift from legs, which causes upper airways edema. the aim of this study is to evaluate if compression stockings could improve such nocturnal volume redistribution and, therefore, improve obstructive sleep apnea.

investigators will apply the following methods: * sleep study, performed through polysomnography * fluid redistribution, by bioimpedance analysis * autonomic nervous system evaluation, by spectral heart rate variability analysis. the study protocol comprises two moments: baseline evaluation (in patients with diagnosed sleep apnea) and after using compression stockings for a one-week period.

Eligibility criteria:
inclusion criteria: * patients under hemodialysis * patients with diagnosed obstructive sleep apnea exclusion criteria: * congestive heart failure * urine output \> 500 ml/day * non-sinusal cardiac rhythm * refusal to give written consent

Keywords: hemodialysis obstructive sleep apnea compression stockings