Kornimate/medical-research-clean huggingface dataset:
comparing exposure v imagery rescripting in people with ocd: a sced

Conditions: Obsessive-Compulsive Disorder (OCD)

Summary: individuals with ocd may experience intrusive future orientated thoughts and images, which are extremely distressing and interfering in life. this project aims to explore whether imagery rescripting or exposure may be a more effective intervention for individuals with ocd experiencing such images.


Eligibility criteria:
inclusion criteria: * 18 years or over * main diagnosis of ocd (assessed by the structured clinical interview for icd11) * must report future orientated images that are distressing and ego-dystonic exclusion criteria: * psychosis, bipolar disorder, or trauma disorder * current stimulant or hallucinogenic misuse, alcohol or substance misuse or dependence * intellectual disability, dementia, serious cognitive impairment, or organic brain disorder * personality disorder as the main problem * active suicidality * concurrent engagement in other psychotherapy * a patient may be taking anti-depressant medication so long as the dose has been stable for 6 weeks and there is no plan to increase the dose.
validation of a wearable non-invasive device (the patch)

Conditions: Sleep Apnea

Summary: bresotec has designed and developed a standalone wearable device (the patch), that can record tracheal sounds with a microphone attached just above the suprasternal notch of the subject.

the patch also has a 3-dimensional accelerometer to record body position. furthermore, the patch records oxygen saturation using an fda cleared pulse oximeter, nonin 3150 wristox2® with bluetooth low energy. we have developed advanced signal processing algorithms to detect apneas and hypopneas. many of these techniques for analyzing breathing sounds and detecting apneas and hypopneas have been published in peer-reviewed journals. the goal of this study is to validate the patch against polysomnography (psg) for use as an aid in the diagnosis of sleep apnea for adult patients. our primary objective is to assess whether the estimated apnea-hypopnea index (ahi) calculated by the patch agrees with the results of an in-laboratory psg.

Eligibility criteria:
inclusion criteria: * inclusion criteria are men and women 18 years and above, who are referred to either the university health network (uhn), toronto rehabilitation institute (tri) or toronto general hospital sleep laboratories for overnight psg because of a suspicion of a sleep disorder. it is intended for the general outpatient population. exclusion criteria: * exclusion criteria are patients with suspected complicated co-morbidities including in-hospital patients and those who self-report diagnosis of heart failure, recent stroke, neuromuscular disorders, renal failure, obesity hypoventilation, copd, or other severe lung diseases.
efficacy and safety study for piolin® shampoo

Conditions: PEDICULOSIS

Summary: this study aims to demonstrate the therapeutic efficacy and safety of shampoo piolin ® in the treatment of human pediculosis. will be treated 212 patients aged 2-60 years with the infestation, along with the people in your family life. all will be submitted to the dosing regimen recommended in the package insert. 100% of the sample shall be subjected to clinical evaluation through comb, pre and post treatment and monitored after thirty days for evaluation of safety and possible adverse effects that may arise related to any of the components of the formula. the efficacy study is active comparator, non-inferiority.


Eligibility criteria:
inclusion criteria: * volunteers healthy female and male ; * children between 2 and 17 years ; * increased from 18 years; * availability of volunteer to maintain a stable weight during the study period (ranging from less than 2 kg) ; * displays lice infestation on clinical examination ; * voluntary participation ; * signing the consent form and / or free and informed consent ; * willingness to comply with study procedures ; * complying that researchers can make use of all the information nameless , including publication and comply with the use and storage of all information confidential . exclusion criteria: * use paint or other chemicals on the hair in the last four weeks that precede the study ; * concomitant therapy ; * women who are pregnant or intend to become pregnant during the study ; * infants ; * volunteers not willing to sign and adhere to the statement of consent ; * known hypersensitivity to the product ; * participation in any other clinical study ; * any other condition that the investigator decides that might interfere with the results or involving a risk to the volunteer study

Keywords: piolin®, pediculosis, efficacy, safety, phytomedicine, arruda, ruta
use of a gamma-ifn assay in contact tracing for tuberculosis in a low-incidence, high immigration area

Conditions: Tuberculosis; Latent Tuberculosis Infection

Summary: after exposure to an active case of tuberculosis (tb), close contacts may be infected. they are then considered as having latent tuberculosis infection (ltbi). detecting ltbi is the main goal of contact tracing procedures after exposure to tb. until recently, the only test available for detecting ltbi was the tuberculin skin test (tst). more recent tests are now available (interferon-gamma release assays: igra), which are more specific and sensitive than the tst. this study compares the tst and an igra in the routine activity of contact tracing in our area.

setting: a tb clinic in geneva, switzerland, a low incidence area for tb with a high immigrant population. aim of study: to compare results of an igra test (t-spot.tb, oxford immunotec, uk) and the tst, and their correlation with exposure scores in subjects exposed to cases of contagious tb. methods: prospective study of all contacts screened in our area, and accepting to be included. simultaneous recording of age, gender, origin, history of recent travels or exposure, bcg vaccination status, infectiousness of index case, 5 different exposure scores, tst, and result of the t-spot.tb blood test. univariate and multivariate analysis.

Eligibility criteria:
inclusion criteria: * exposure to a case of contagious tb * willingness to participate in study exclusion criteria: * known hiv infection * known previous tb or treatment for ltbi

Keywords: tuberculosis latent tuberculosis infection interferon gamma release assay contact tracing
plasma radiofrequency ablation at low temperature versus electrocautery block resection at high frequency for localized recurrent nasopharyngeal carcinoma

Conditions: Surgery; Recurrent Nasopharyngeal Carcinoma

Summary: this study aims at exploring whether plasma radiofrequency ablation at low temperature is associated with better survival outcome in localized recurrent nasopharyngeal carcinoma by conducting a randomized controlled trial of plasma radiofrequency ablation at low temperature versus electrocautery block resection at high frequency for localized recurrent nasopharyngeal carcinoma. if the hypothesis is confirmed, it is expected to provide a convenient choice for the surgical treatment of localized recurrent nasopharyngeal carcinoma.


Eligibility criteria:
inclusion criteria: 1. at least 6 months disease free interval (defined as duration between the initial course of radiotherapy and recurrence) 2. histopathologically diagnosed with undifferentiated or differentiated, nonkeratinizing nasopharyngeal carcinoma. 3. resectable recurrent nasopharyngeal carcinoma: a) recurrent t1n0m0 according to the american joint committee on cancer (ajcc) 8th staging b) recurrent t2n0m0(the tumor was confined to the surface of the parapharyngeal space and was more than 0.5cm away from the internal carotid artery) according to the american joint committee on cancer (ajcc) 8th staging 4. age: 18-70 years old. 5. subjects must sign an informed consent form. exclusion criteria: 1. karnofsky score (kps)≤70. 2. has known subjects with other malignant tumors. 3. has seriously mental disease. 4. uncontrolled clinically significant heart disease and pulmonary dysfunction. 5. pregnancy or breast feeding.

Keywords: recurrent nasopharyngeal carcinoma plasma radiofrequency ablation electrocautery block resection
traditional turkish military music and endoscopic retrograde cholangiopancreatography

Conditions: Endoscopic Retrograde Cholangio-Pancreatography; Anxiety; Pain

Summary: this study aims to investigate the effect of traditional turkish military music on patients who will have endoscopic retrograde cholangio-pancreatography procedure on vital signs, anxiety, and pain. this will be a randomized controlled experimental study. the study will be conducted with two groups: the intervention group (n=36) and the control group (n=36). the control group will receive standard care while the intervention group, in addition to standard care, will be listened to traditional turkish military music, which consists of music selected by an expert on the type of music, by the researchers for 15 minutes before the procedure.


Eligibility criteria:
inclusion criteria: * patients aged 18 or above, * with a scheduled ercp procedure * with the asa grade level of i-ii clinically * without a hearing/speech impairment * willing to participate in the research * without a mental problem or diagnosis of psychiatric disorder * without any a diagnosis of depression exclusion criteria: * patients below 18 years of age, * patients with an emergency ercp procedure * with a hearing/speech impairment * not willing to participate in the research * with a mental problem or diagnosis of psychiatric disorder * with a diagnosis of depression
researching the affect of sevoflurane in cardiac surgery on delirium

Conditions: Postoperative Delirium

Summary: many risk factors have been identified for delirium after open heart surgery . one of the main risk factors; duration of stay on mechanical ventilator . our hypothesis; the use of sevoflurane during aortic cross-clamping reduces the need for long-acting intravenous anesthetic agents. therefore, patients will be weaned from the mechanical ventilator in a shorter time. patients with shorter stays on mechanical ventilation develop less postoperative delirium.

standard anesthesia management will be applied in the induction and maintenance of anesthesia. in the induction of anesthesia 1mg/kg lidocaine , 1.5-2mg/kg propofol , 1 mcg /kg fentanyl citrate, 0.6 mg/kg rocuronium bromide will be administered. sevoflurane for maintenance of anesthesia and propofol and fentanyl if needed bolus will be applied. bis monitoring will be performed to control the depth of anesthesia. patients' peroperative hemodynamic levels, arterial blood gas levels, operation time, pump time, aortic cross clamp time, postoperative complications , the amount of blood and fluid used, the amount of iv anesthetic used, the extubation time, the length of stay in the intensive care unit, the length of stay in the hospital will be followed and recorded. postoperative delirium follow-ups of the patients will be recorded once a day by the same investigator using the nursing delirium screening scale and delirium rating scale revised-98 until they are discharged from the hospital .

Eligibility criteria:
inclusion criteria: patients with a score of 25 and above in the mini-mental state test performed in the preoperative period exclusion criteria: those who are scheduled for emergency surgery those with known dementia and/or neurological disease
reducing pm-associated cv health effects for seniors

Conditions: Cardiovascular Diseases in Old Age

Summary: the objective of this study is to investigate the effectiveness of air filtration at reducing personal-level exposures to fine particulate matter (pm2.5) and mitigating related cardiovascular (cv) health effects among older adults in a residential facility in a representative us urban location. we enrolled 40 nonsmoking older adults into a randomized double-blind crossover intervention study with daily cv health outcomes and pm2.5 exposure measurements. the study was conducted in a low-income senior living apartment building in downtown detroit, michigan. participants were exposed to three 3-day scenarios separated by one-week washout periods: unfiltered ambient air (control), low-efficiency (le) "hepa-type", and high-efficiency (he) "true-hepa" filtered air using air filtration systems in the bedroom and main living space of each residence. the primary outcome was brachial blood pressure (bp). secondary outcomes included noninvasive aortic hemodynamics and pulse wave velocity and heart rate variability. pm2.5 exposures were measured in the participants' residences as well as by personal-level monitoring.


Eligibility criteria:
inclusion criteria: * 50 to 85 years old * non-smoking healthy adults exclusion criteria: * smoke or anyone in your residence smokes. * had a cardiovascular event within the past 6 months (such as myocardial infarction (heart attack), angina, cardiac or carotid surgery or stent, diagnosed peripheral arterial disease, aortic aneurysms, treated heart failure, any treated arrhythmia including atrial fibrillation) * have renal disease requiring dialysis. * have had medication changes in the past 6 weeks. * use supplementary oxygen.
detection of csf next generation sequencing in the application of brain metastases from lung adenocarcinoma or meningeal metastasis

Conditions: Recruitment

Summary: this study aimed to detect cell free dna (cfdna) in the cerebrospinal fluid and plasma, and to determine whether cfdna can be used for concomitant diagnosis to improve the treatment efficacy and prognosis of patients with brain (meningeal) metastasis by monitoring tumor-related genetic mutations in cfdna in the plasma and cerebrospinal fluid.

this study planned to enroll 50 patients with lung cancer diagnosed with brain (meningeal) metastases, and all cases were slated to receive radiotherapy and targeted therapy. patients' clinical data were collected (including but not limited to: age at diagnosis with brain (meningeal) metastases, kps score, smoking history, stage of disease at diagnosis, time to progress to brain metastases, number of brain metastases, extracranial metastases (ecm), and systemic disease at the time of brain metastases. anticoagulated whole blood and anticoagulated cerebrospinal fluid were collected before local treatment (samples of primary cancer tissue and metastatic carcinoma of some patients were preserved) and at 7 days, 1 month, 3 months, as well as 6 months after the treatment (time of sample retention was to be determined, figure 2). dna was extracted from tumor tissues, genomic dna was extracted from leukocytes, and cfdna was extracted from plasma and cerebrospinal fluid, for complete quantitative detection of dna, dna library construction, as well as targeted capture sequencing. tumor-related genes were analyzed, and changes in the tumor burden during the treatment process were evaluated. the clinical significance of cfdna in the plasma and cerebrospinal fluid for treatment efficacy and prognosis was evaluated, and compared with that of clinical indicators of treatment efficacy. this study involved two stages. the first stage was a pre-experiment: samples were retained from 3-5 cases, and mutations in tumor-related genes in the cfdna in plasma and cerebrospinal fluid were compared. the investigators analyzed, combined with clinical indicators, whether mutations of cfdna in plasma accord with that of the cerebrospinal fluid and whether mutations of cfdna in cerebrospinal can reflect the mutational status of tumor cells. the second phase was conducted by expanding the number of cases, based on the first stage.

Eligibility criteria:
inclusion criteria: 1. patients with confirmed diagnosis of lung adenocarcinoma with brain (meningeal) metastasis. 2. samples collection should be allowed. exclusion criteria: 1. pregnant women 2. minors (subjects less than 18 years of age)

Keywords: lung adenocarcinoma with brain (meningeal) metastasis
evaluation of novel lung function parameters and quantitative computed tomography (qct) in patients with pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease; Bronchial Asthma; Interstitial Lung Disease

Summary: current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. the investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.


Eligibility criteria:
inclusion criteria: * known or suspected pulmonary lung disease * indication for computed tomography exclusion criteria: * pregnancy * inability to participate
effectiveness of clozapine versus olanzapine for treatment-resistant schizophrenia

Conditions: Schizophrenia

Summary: this study will determine the effectiveness of clozapine versus olanzapine in treating people with schizophrenia that has not improved with treatment.

this is a two-year open-label, randomized trial of the comparative effectiveness of clozapine versus olanzapine in patients with treatment refractory schizophrenia. the objective is to determine whether in a naturalistic setting olanzapine is a logical treatment choice (before using the more toxic clozapine) for some treatment refractory patients.

Eligibility criteria:
inclusion criteria: * age 20-60 years; * diagnosis of treatment refractory schizophrenia or schizoaffective disorder; * bprs score \> 21 (0-6) scale; * either two 6-8 week trials of typical neuroleptics given at a dosage of 600 mg/day of cpz or its equivalent or one 6-8 week trial of an atypical antipsychotic at a reasonable dose (i.e. risperidone 4-6 mg/day); * the patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent; * clinically appropriate for clozapine or olanzapine exclusion criteria: * current substance abuse; * suicide or homicide risk; * pregnancy or lactation; * history of seizures or blood dyscrasias

Keywords: clozapine olanzapine
mechanisms for alcohol treatment change [match] study

Conditions: Alcohol Consumption

Summary: a 5-arm randomized trial to determine what components of a text message intervention are necessary to reduce hazardous drinking among young adults and mechanisms through which these changes occur.

young adults ages 18-25 have high rates of hazardous alcohol use and alcohol-related consequences. the emergency department (ed) provides an important opportunity to identify young adult hazardous drinkers who could benefit from interventions. a text message (tm) intervention was shown to reduce alcohol consumption among young adult ed patients, showing durable effects over 9-months. the tm intervention uses behavior change techniques with the largest effect sizes in an alcohol intervention meta-analysis: "goal commitment" and "self-monitoring", along with real-time "feedback". however, the unique effect of these ingredients, and mechanisms (processes occurring within the individual) through which they operate to reduce drinking remain unclear, a critical gap addressed by this project. young adult ed patients (ages 18-25) who screen positive for hazardous drinking will be recruited to participate in a randomized trial to determine how best to help individuals reduce hazardous drinking. all participants will be asked to complete web-based surveys at baseline, 12 and 24 weeks after enrollment, complete brief psychomotor tasks weekly for 14 weeks, and respond to text messages each thursday and sunday for the next 12 weeks. those randomized to the tm interventions will additionally receive feedback on their text reports. the four tm intervention arms are: (1) drinking cognition feedback (dcf), (2) alcohol risk feedback (arf), (3) adaptive goal support (ags) and (4) a combination of dcf, arf, and ags=combo). study results have implications for designing efficient mobile interventions, and developing a dynamic theory of behavior change.

Eligibility criteria:
inclusion criteria: * total score of \>2 for women or \>3 for men on the audit-c * at least 1 binged drinking episode in the prior 30 days exclusion criteria: * no cell phone with text messaging * have been diagnosed with an alcohol or substance use disorder * pregnant or planning pregnancy * taking medicine for a psychiatric disorder (including depression, anxiety) * taking any medicine that could interact with alcohol
prospective multicenter study to characterize the real-world evidence regarding safety and performance of the ptca catheters family

Conditions: Coronary Artery Stenosis

Summary: the purpose of this post market study is to collect clinical data of the arthesys ptca catheters family during angioplasty intervention of coronary vessels or coronary bypass graft stenosis to support mdr submission.


Eligibility criteria:
inclusion criteria: * patient with a percutaneous intervention to a native coronary or coronary bypass graft indication * patient \>18 years * patient who understands the trial requirements and the treatment procedures and provides written informed consent exclusion criteria: - patients will not be included if they are under judicial protection, guardianship or curatorship or if they are deprived of their liberty by judicial or administrative decision.
a study comparing the risk of serious infections and malignancies with deucravacitinib or biologics in japanese patients with psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to further evaluate the safety of deucravacitinib treatment in japanese patients with psoriasis in the real-world setting


Eligibility criteria:
inclusion criteria: * participants with prescriptions in deucravacitinib or any biologics as comparator group during the indexing period. * participants with at least one confirmed diagnosis of disease code for psoriasis within 12 months prior to the index date. * aged 18 years or older at the index date exclusion criteria: * participants with prescription in deucravacitinib or any biologics as comparator group prior to the index date. * participants with fewer than 12 months of available claim records prior to the index date. * participants with no claims record within 1-year after the index date (no visit after the index date). * specific for serious infection: participants who had at least one disease code of hospitalized infection in the 60 days period before the index date. * specific for malignancy: participants who had at least one disease code of malignancy prior to the index date

Keywords: psoriasis (pso)