Kornimate/medical-research-clean huggingface dataset:
exploring patient treatment preferences for chronic pelvic pain: a mixed methods study

Conditions: Chronic Pelvic Pain

Summary: this research is studying what things change the way people think about treatment for chronic pelvic pain (cpp). the study team is also interested in whether a web-based educational and self-management program for chronic pelvic pain changes how people think about chronic pelvic pain treatments. the program contains several different self-guided modules that include cognitive and behavioral structuring, self-administration of acupressure, engaging in physical activity, and a brief introduction to pelvic floor physical therapy techniques. the study hypothesis is that patients with cpp will report that prior treatment experiences and most trusted source of medical information will be associated with baseline perceptions of various cpp treatment modalities.


Eligibility criteria:
inclusion criteria: * have chronic pelvic pain, defined as moderate to severe pelvic pain (based on protocol) for greater or equal to(≥) 6-month duration, and is non-cyclic, occurring for at least 14 days of each month. * must be scheduled for a new patient visit with the chronic pelvic pain and endometriosis referral clinic within the department of obstetrics and gynecology at the university of michigan for treatment of chronic pelvic pain. * access to internet via computer or smartphone * english-language proficiency (current version of the website is in english) * the study team will attempt to recruit a diverse group of patients, with attention to diversity in race, ethnicity, education level, rural vs urban locality, sexual orientation, and gender identification. exclusion criteria: * severe physical impairment precluding participating in internet-based program (for example, complete blindness or deafness) * prior care within the chronic pelvic pain and endometriosis referral clinic within the department of obstetrics and gynecology at the university of michigan for treatment of chronic pelvic pain (seen previously but meets criteria for new patient visit because \> 3 year interval since last clinic visit).

Keywords: structured interview questionnaires web-based educational program
management of abdominal pain in acute gastroenteritis patients with hyoscine butylbromide

Conditions: Acute Gastroenteritis; Abdominal Pain

Summary: one of the most common complaints of admission to the emergency room is gastroenteritis. one of the most common complaints in acute gastroenteritis is abdominal pain. the aim of our study is to investigate whether hyoscine butylbromide used within the indication has an effect on abdominal pain due to acute gastroenteritis. the main purpose of our study is to reduce the pain of the patient at 30th and 60th minutes compared to 0th minute.


Eligibility criteria:
inclusion criteria: * patients with watery stools starting in the last 2 weeks and 3 times in 24 hours and abdominal pain exclusion criteria: * peritonitis * hemodynamic instability * pregnancy * inability to give consent * medication given in the emergency room before being included in the study * taking pain medication within 4 hours * diabetes mellitus and other neuropathic diseases
olmesartan medoxomil and diabetic nephropathy

Conditions: Type 2 Diabetes Mellitus; Diabetic Nephropathy; Proteinuria; Renal Disease

Summary: evaluation of several olmesartan dosages compared to losartan on proteinuria, renal function and inflammatory markers in patients with diabetic nephropathy


Eligibility criteria:
inclusion criteria: * male or female european out-patients * greater than or equal to 30 years of age * type 2 diabetes first diagnosed at greater than or equal to 30 years of age * urinary protein excretion between 200-4000 mg/day exclusive * mean sitting dbp less than or equal to 110 mghg * medically justifiable to withdraw antihypertensive treatment due to poor tolerability or inefficacy of previous treatment, or verification that treatment is still necessary exclusion criteria: * females pregnant, nursing or planning to become pregnant or were of childbearing potential and not using acceptable methods of contraception * secondary forms of hypertension other than diabetic nephropathy, malignant hypertension or patients with sitting dbp exceeding 110 mmhg or sitting sbp exceeding 200 mmhg * ecg evidence of 2nd or 3rd degree av-block, atrial fibrillation, cardiac arrhythmia (requiring therapy) or bradycardia * presence of significant cardiovascular disease * significant cerebrovascular disease, gastrointestinal, haematological or hepatic disease or myocardial infarction in last 12 months or a previous history of any serious underlying disease * concurrent renal disease, nephrectomy and/or renal transplant, serum creatinine level greater than or equal to 2.0 mg/dl or creatinine clearance clcr less than or equal to 50 ml/min * clinically significant lab abnormalities (asat/sgot, alat/sgpt and γ-gt ) * serum potassium level \ 5.5 mmol/l * treatment of concurrent indications with drugs or medication which could have influenced bp * history of hypersensitivity, lack of response or contraindication to ang ii-antagonists, hctz or atenolol, or hypersensitivity to related drugs (cross-allergy)

Keywords: type 2 diabetes mellitus diabetic nephropathy inflammatory markers proteinuria renal disease
intranasal fentanyl in combination with midazolam versus midazolam alone for pediatric facial laceration repair

Conditions: Facial Laceration; Anxiety

Summary: the purpose of the study is to compare the effectiveness of a combination of intranasal fentanyl and intranasal midazolam to intranasal midazolam alone for analgesia and anxiolysis in patients presenting for facial laceration repair in the pediatric emergency department.

this study will be a single blind (blinded observer) randomized control trial to evaluate the efficacy of the combination of intranasal fentanyl and intranasal midazolam compared to intranasal midazolam alone for analgesia and anxiolysis during pediatric facial laceration repair.

Eligibility criteria:
inclusion criteria: * facial laceration requiring repair with sutures * english or spanish-speaking parent/guardian exclusion criteria: * lacerations requiring iv sedation or subspecialist involvement * patient has other injuries requiring medical attention * patient has vital sign instability, per physician discretion * patient has autism spectrum disorder * patient has allergies to either medication

Keywords: laceration repair facial laceration anxiety midazolam fentanyl
sjov with wnj in microlaryngeal surgery

Conditions: Other Complications of Surgical and Medical Procedures

Summary: the key to a successful microlaryngoscopy is adequate operative field exposure and illumination. a variety of airway control procedures has been developed to improve operative exposure. a small size endotracheal tube is commonly used. however, some surgeon may suggest a 'no-tube' technique to optimize the surgical field. this study aims to investigate effectiveness and safety of a novel technique by supraglottic jet oxygenation and ventilation (sjov) via nasal approach to facilitate optimal visualization in laser microlaryngeal surgery for small vocal polyps resection.

the allocation sequence is generated by computer random number generation, and the allocation is placed in sequentially numbered opaque sealed envelopes by a non-investigator. enrolment and data collection are performed by trained research staff who are not involved in the care of the patients. the treating clinicians are not possible to be blinded to the assignment group, but all other staff involved in both the collection and collation of data, and administration of neurocognitive testing, are blinded to group allocation. the primary measurement is numerical rating scale (nrs) rated by surgeon according to surgical exposure and visualization. the secondary measurements are operation duration, and intraoperative pulse oximetry (spo2), petco2. the continuous variables were expressed as means ± standard deviation (sd) whereas categorical variables were expressed as frequency and percentage for data description.

Eligibility criteria:
inclusion criteria: * patients scheduled for laser laryngeal surgery under general anesthesia exclusion criteria: * patients with cardiac, pulmonary, hepatic, or renal dysfunction. patients with nasal disease. patients with anticipated difficult airway.

Keywords: jet ventilation supraglottic intranasal microlaryngeal surgery
pilot study of haloperidol to treat critical illness delirium

Conditions: Delirium; Critical Illness

Summary: the goal of this study is to determine whether haloperidol reduces the time on the breathing machine in critically ill patients with delirium.

delirium is a frequent end-organ complication of critical illness and is an independent predictor of mortality in mechanically ventilated patients. however, management of delirium is a major therapeutic challenge and it is unknown if current therapies are disease modifying or function only as symptom management. haloperidol has been demonstrated to reduce delirium in retrospective studies. this study is a pilot prospective randomized clinical trial in the denver health medical icu to determine if haloperidol in addition to an evidence-based standard-of-care sedation protocol for the management of delirium results in a shortened duration of intubation and improvements in post-extubation cognitive status. the haloperidol dose is administered using titration-protocol guided by nursing assessment of delirium using the confusion assessment method for the icu (cam-icu). the primary outcome is ventilator-free days out of the first 28, and secondary outcomes include duration of delirium, length and cost of hospitalization, 28-day mortality, usage of other sedatives, serum markers of delirium (neuron-specific enolase and protein s-100b), and cognitive-function scores at the time of icu discharge, hospital discharge, and six-month follow-up. the goal of the 20-patient pilot is demonstrating safety of the haloperidol protocol, as evaluated by an independent data-safety monitoring board. following approval of the dsmb, 122 more patients will be enrolled in the full rct to achieve power for an 80% chance of detecting a 40% decrease in duration of intubation with p \< 0.05.

Eligibility criteria:
inclusion criteria: * mechanically ventilated within 24 hours of arrival to the icu * delirium as assessed by cam-icu within 24 hours of arrival to the icu * age \> 18 exclusion criteria: * known allergy to haloperidol or other neuroleptics * neurological injury or trauma * \< 24 hours after a major operation * history of axis i psychiatric disorder or significant dementia * baseline qtc of \> 500 msec or a pacemaker which makes the qtc uninterpretable * history of seizure disorder * morbid obesity (\> 1kg/cm body weight) * hepatic failure (child's class c) * neuromuscular disease (c5 or higher spinal cord injury, als, guillain-barre syndrome, and myasthenia gravis) * malignancy or other irreversible disease or condition for which 6 month mortality is estimated to be ≥ 50% * pregnancy (negative pregnancy test required for women of child-bearing potential)

Keywords: randomized controlled trial delirium haloperidol
randomized comparison of curved cutter stapler and linear stapler

Conditions: Rectal Neoplasm; Surgical Stapler

Summary: this study aims to compare the safty and technical accessibility of linear stapler and curved cutter stapler during mid to low rectal cancer surgery.


Eligibility criteria:
inclusion criteria: * biopsy proven adenocarcinoma of rectum. * preoperative stage i-iii * patient who is expected to undergo low anterior resection at samsung medical center. * age \> 19 years old exclusion criteria: * patient with complicated rectal cancers(obstruction, perforation, abscess) * patient who needs to undergo emergency operation. * patient who can not undergo general anesthesia. * patient who does not agree with the informed consent or does not have the ability to understand content of the trial .
pharmacokinetic (pk)research on chinese children of hemophilia

Conditions: Pharmacokinetics

Summary: the study start on june 30, 2018. the severe(f ⅷ\<1%) hemophilia a children without f ⅷ inhibitor combining were recruited to test the concentration of the drug in the blood to provide better treatment.

through the integration of two technologies, pharmacokinetics and comprehensive evaluation system, we can improve the individualized prevention and treatment of hemophilia in chinese children and achieve precise customization of treatment plans. rational use of medical resources, but also fully achieve the prevention and treatment goals.

Eligibility criteria:
inclusion criteria: * fⅷ\<1% , * 1-14years old, * there have been at least one history of bleeding in any joint of the knee, elbow, or ankle. * a blood product containing fviii is applied. * there were no inhibitors at the time of enrollment, and there was no inhibitor-positive history and family history. * clinical visits are available on a regular basis and data is available, and preventive treatment is available prior to enrollment. * the child was enrolled in the group and the guardian agreed. exclusion criteria: * combining other disease researchers believes that it is not suitable for enrollment. * fviii inhibitor was found. * refuse to participate in research

Keywords: hemophilia a，pharmacokinetics
evaluation of the impact of a pharmaceutical interview on the adherence to hormonotherapy in women with breast cancer

Conditions: Breast Cancer

Summary: breast cancer is the first cancer in women and 60% of new cases occurring in women 50 to 74 years old. with about 50,000 new cases, it is the second cancer the most serious cancers. in the therapeutic strategy, hormone therapy takes pride of place by allowing a significant reduction in the recurrence rate. for the hormonotherapy be effective, patient compliance should be optimal during treatment. different factors or barriers may lead to a lack of adherence, such as the occurrence of adverse effects, treatment fatigue, a difficult relationship with the health care team, beliefs about success or the need for treatment. in order to facilitate the compliance of hormonoherapy treatment by patients, it is important to include different health professionals such as pharmacists.

hormonotherapy adherence to breast cancer patients could be improved by : * the use of electronic pill dispensers since the first prescription to visualize the level of compliance of each patient and study with her the various factors that can limit it. * motivational, semi-directed and scheduled drug interviews at regular intervals throughout the study over a period of 18 months to visualize the compliance rate (ratio of the number of tablets taken by the patient on the number of tablets to be taken theoretically over the period), to evaluate the presence or absence of iatrogenesis specific to hormone therapy and to ensure adequate medical follow-up.

Eligibility criteria:
inclusion criteria: 1. woman, over 18 years old. 2. with non-metastatic breast cancer. 3. treated by hormone therapy, regardless of the molecule (cancer rh positive). 4. in primary prescription of hormone therapy. 5. first prescription by a medical oncologist, surgeon or radiation therapist from the cgfl. 6. pharmacy of the patient located in the perimeter defined in the context of the study (residents in the burgundy region between a triangle delimited by the towns of chatillon sur seine, dole and chalon sur saone. 7. woman who received information about the study and gave her written consent. 8. affiliation to a social security scheme. 9. participant agreement of the referent city pharmacy of the patient. exclusion criteria: 1. metastatic patient. 2. patient participating in another epidemiological or clinical study of adherence and / or hormone therapy. 3. patient under guardianship, curatorship or safeguard of justice. 4. patient with severe psychiatric disorders or who does not speak the french language 5. refusal to participate in the study. 6. refusal of participation of the referent city pharmacy of the patient.

Keywords: hormonotherpy compliance
automatic early melanoma detection by ultrahigh resolution three dimensional optical coherence tomography

Conditions: Melanoma

Summary: the investigators will use optical coherence tomography to detect the ex-vivo tissue image of surgical removed melanoma or other benign pigmented lesions of skin.

the investigators will use an advanced high resolution 3d optical coherence tomography (oct) technology to observe skin tissue images in ex vivo culture. parts of melanoma or benign pigmented lesions specimens derived from biopsy or surgical excision specimen will be observed by 3d optical tomography. a tiny tissue fragment of melanoma or benign pigmented lesions will be taken from surgical specimen without interference normal pathological evaluation. the location of melanocytic cells in melanoma or benign tissue fragments will be mapped by the 3d optical coherence tomography (oct). the 3d optic tomography system utilize a ce:yag optical fiber as light source and also combined with confocal microscopy. taken together, these features made the 3d optic tomography system have very high resolution and suitable for single cell imaging. this study will not interfere with the normal medical practice and had no impact on patient's safety and health. all of the materials will be destroyed once the experiments are done. the enrollment criteria will be dermatological patients who need to surgical intervention.

Eligibility criteria:
inclusion criteria: * patients aged older than 20 years old * patients who had melanoma, melanoma in situ, and/or other benign pigmented lesions, * patients who had non-melanoma skin cancers (basal cell carcinoma, or squamous cell carcinoma). * patients who had precancerous skin lesions (bowen's disease, actinicc keratosis) exclusion criteria: • pregnant women.

Keywords: optical coherence tomography
evaluation of neuromuscular blockade responses in statin-using and non-using patients

Conditions: Neuromuscular Blockade; Statin-Associated Myopathy; Neuromuscular Monitoring

Summary: this study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins. the study will assess the depth of neuromuscular blockade, recovery time, and postoperative residual curarization using train-of-four (tof) monitoring, with the primary goal of determining whether statin use alters the neuromuscular blockade management.


Eligibility criteria:
inclusion criteria: * age 18-75 years * asa classification i, ii, iii * bmi 18-30 * statin use for at least 3 months or no prior statin use * elective surgery requiring general anesthesia with endotracheal intubation * signed informed consent for participation in the study exclusion criteria: * asa classification iv or higher * bmi \ 30 * history of liver or renal insufficiency (creatinine \>1.6, liver function tests \>2x normal) * neuromuscular, psychiatric, or neurological disorders * pregnancy * use of drugs affecting neuromuscular function (e.g., anticonvulsants, aminoglycosides) * history of malignant hyperthermia * respiratory disorders, including sleep apnea * allergy to anesthetic drugs used in the study
daproca pelvic lymph node irradiation to prostate for high risk prostate cancer: phase i/ii study

Conditions: Prostate Cancer

Summary: this is a prospective, open label 1 arm study, multicentre, phase i/ii clinical safety study. the trial is designed to gain initial safety and efficacy data on pelvic lymph node radiation with simultaneous integrated boost to prostate in high risk prostate cancer patients.


Eligibility criteria:
inclusion criteria: * adenocarcinoma * t3 tumor and either gleason 8-10 and psa ≤ 70,or psa ≥ 30 and psa ≤ 70, or t1-t3 and psa ≤ 70 and n1 * no distant metastases exclusion criteria: * pelvic co-morbidity such as crohns disease or ulcerative colitis * uncontrolled heart or lung morbidity * prior radiation treatment of pelvic region * age \> 75 years

Keywords: prostate cancer locally advanced lymph node positive radiation therapy morbidity early morbidity late morbidity
a retrospective, observational registry of participants with avian influenza infection

Conditions: Influenza

Summary: this is a global, multi-center, observational registry of participants with suspected or confirmed infection with avian influenza a h5n1. data are collected through retrospective abstraction, from detailed case reports that may be published and available in the public domain, or as incident cases received directly from the treating physician or other medical personnel.


Eligibility criteria:
inclusion criteria: * participants who develop influenza-like symptoms and who are considered to be epidemiologically linked by time, place, and exposure to a probable or confirmed avian influenza or human case of h5n1 infection are eligible for inclusion in the registry. cases with atypical symptom presentation (e.g., non-respiratory) are also included, in keeping with evolving knowledge about the clinical presentation of avian influenza. * participants with documented positive serological test who either remain asymptomatic or experience mild illness only * participants with laboratory confirmation of infection with influenza a (h5n1) who survive long enough to present for medical care exclusion criteria: - there are no exclusion criteria in this study

Keywords: avian influenza
maturation of auditory processing in children with dyslexia compared to average-reading children

Conditions: Dyslexia

Summary: the hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia. these phonological disorders may be linked to abnormalities of the efferent (medial olivocochlear) system modulation and of cortical asymmetry. indeed, the efferent system has an asymmetry in relation to handedness. thus, in right-handed subject, it is predominant on the right side. in contrast, in the subject-handed dyslexic, the efferent system tends to be right-lateralized or non-lateralized. however, after an audio-visual training, normal lateralization can appear. this maturation of the efferent system lateralization during reading acquisition seems to have a particular profile in dyslexics with phonological disorder, especially if it is persistent. this finding allows to consider new prognostic evaluation and speech therapy rehabilitation in the dyslexic child.


Eligibility criteria:
common inclusion criteria * native french speaker and french education * no medical treatment for behavior or neurological disorders (as epilepsy) * normal or corrected vision * right-handed children (edinburgh tets (oldfield, 1971): \>+50%) * normal orl examination * no hearing loss : hearing thresholds not above 15 db between 250 and 4 000 hz * presence of otoacoustic emissions (total amplitude \ 3db for at least 3 frequency bands between 1 and 4 khz) * normal level of intellectual development * regular school attendance for the normal reading children * aged from 6 to less than 11 * normal reading level for the dyslexic children * aged from 8 to less than 11 * diagnostic of dyslexia made by a complet check-up during the 6 last months before the inclusion exclusion criteria * neurological or psychiatric disease incompatible with the testing procedure * ear disease during more than 6 months * normal reading children who have repeat a year * previous speech therapy for normal reading children * not corrected visual acuteness * schooling in a foreign language * foreign language spoken at home with both parents * known hearing deficit * invalid social security

Keywords: dyslexia, medial olivocochlear system, maturation, auditory processing