Kornimate/medical-research-clean huggingface dataset:
combination nicotine replacement for alcoholic smokers

Conditions: Smoking; Alcoholism

Summary: the overall objective of the study is to develop recommendations for treatment programs to help alcoholic smokers to stop smoking. a sample of 175 alcohol dependent cigarette smokers will be recruited from the community and treated in a 6-month outpatient alcohol and tobacco treatment program. the 175 patients will be divided into two groups. one group will receive an active nicotine patch and active nicotine gum. the other group will receive an active nicotine patch and placebo nicotine gum. followup assessments will be conducted for 1-year from the beginning of treatment.


Eligibility criteria:
inclusion criteria: * males and females at least 18 years old. * english speaking. * meets criteria for alcohol dependence or alcohol abuse. * must complete an alcohol detoxification program prior to entering the study. * currently smoking 15 or more cigarettes per day and have at least a 3 year history of smoking. * have a current desire to stop smoking and stop drinking. * willing to complete followup assessments up to 12 months after treatment. * willing to provide names of 2 people who can help locate the subject at followup and the name of one person who can verify information about alcohol and tobacco use. * one person per household. exclusion criteria: * allergy to nicotine patch or nicotine gum. * weigh less than 100 pounds. * use other nicotine products, such as cigars, pipes or smokeless tobacco. * severe skin disorder. * active peptic ulcer. * active joint disease. * heart attack within 3 months prior to entering the study. * pregnant or breastfeeding female who are not on birth control. * currently taking medication to treat alcoholism or smoking, such as naltrexone, disulfiram or bupropion. * poor vision or hearing that would interfere with using a cell phone. * lack of transportation to the treatment site or live at least one hour from the treatment site. * homeless.

Keywords: smoking alcoholism
investigation of pressure pain threshold and hand grip strength in individuals with and without chronic neck pain

Conditions: Neck Pain

Summary: this study will be determined whether the pressure pain threshold and hand grip strength are affected in individuals with neck pain compared to individuals without neck pain.

when the literature is examined, there are studies examining different parameters in different occupations, men and women with neck pain, individuals with cervical disc hernia, and individuals with chronic neck pain. studies have addressed different parameters that may be associated with neck pain from different perspectives. however, no study was found in which the pressure pain threshold and hand grip strengths were determined and the relationship was examined in individuals with and without chronic neck pain. therefore, with this study, it will be determined whether the pressure pain threshold and hand grip strength are affected in individuals with neck pain compared to individuals without neck pain.

Eligibility criteria:
inclusion criteria: * having neck pain complaint for more than three months, * without any diagnosed chronic disease, * have no past or present psychological disorders, * individuals who can speak, read and write turkish. exclusion criteria: * having any neurological, psychiatric or cognitive disorder, * individuals who cannot speak, read or write turkish.

Keywords: pressure pain threshold neck neck pain hand grip strength quality of life
blephacura versus baby shampoo to treat blepharitis

Conditions: Blepharitis

Summary: the aim of the study is to compare the effectiveness in treatment of chronic blepharitis either with a phospholipid liposome suspension compared to a conventional therapy recommendation using diluted baby shampoo.


Eligibility criteria:
inclusion criteria: * patients with blepharitis * 100 eyes of 100 patients (50 patients treated with blephacura, 50 patients treated with diluted baby shampoo) the ratio of female / male is not involved. exclusion criteria: * all patients that are not included in the group of inclusion criteria
clinical effectiveness of 10 cm^2 rivastigmine patch in patients with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: this study evaluated the safety and efficacy of 10 cm\^2 rivastigmine patch in patients with alzheimer disease (mmse 10-26). the primary objective was the percentage of patients who stayed on the target size of 10 cm\^2 for at least 8 weeks. this proportion was then compared to historical data of the percentage of patients who could reach a rivastigmine capsule target dose of 12 mg and stay on it at least 8 weeks.


Eligibility criteria:
inclusion criteria: * males, and females not of child-bearing potential (surgically sterile or at least one year postmenopausal), of at least 50 years of age * probable alzheimer's disease according to the nincds-adrda (national institute of neurological and communicative diseases and stroke/alzheimer's disease and related disorders association) and dsm-iv (diagnostic and statistical manual of mental disorders) criteria * mmse (mini-mental state examination) score of \> 10 and \< 26 * patients initiating therapy for the first time with a cholinesterase inhibitor (patients prescribed both rivastigmine and memantine are allowed) * patients who failed to benefit from previous cholinesterase inhibitor treatment exclusion criteria: * patients not treated according to the product monograph for rivastigmine capsules * patients involved in a clinical trial * current diagnosis of an active skin lesion/disorder that would prevent accurate assessment of the adhesion and potential skin irritation of the patch (e.g., atopic dermatitis, wounded or scratched skin in the area of the patch application) other protocol-defined exclusion criteria applied to the study.

Keywords: alzheimer's disease rivastigmine patch
safety, tolerability and pharmacodynamic effect of fazirsiran (tak-999, aro-aat)

Conditions: Alpha 1-Antitrypsin Deficiency

Summary: the purpose of aroaat2001 (sequoia) is to evaluate the safety, efficacy and tolerability of multiple doses of the investigational product, fazirsiran injection, administered subcutaneously to participants with alpha-1 antitrypsin deficiency (aatd).

participants will be enrolled to receive multiple subcutaneous injections of fazirsiran injection (also referred to as tak-999 injection or aro-aat injection) or placebo. eligible participants will require a pre-dose biopsy completed as part of the study within the screening window. however, any participant with a biopsy result within 1 year of screening showing no fibrosis does not require a pre-dose biopsy. only participants who have liver fibrosis will undergo a post-dose biopsy and may continue treatment in an open-label phase.

Eligibility criteria:
inclusion criteria: * diagnosis of aatd * liver biopsy at screening indicating liver fibrosis (score less than f4); a patient with no fibrosis may participate based on a previous biopsy conducted within one year * women of childbearing potential must have a negative pregnancy test, cannot be breastfeeding, and must be willing to use contraception * willing to provide written informed consent and to comply with study requirements * non-smoker for at least 1 year * no abnormal finding of clinical relevance at screening exclusion criteria: * clinically significant health concerns other than aatd * previous diagnosis or diagnosis at screening of definitive liver cirrhosis * previous lung or liver transplant due to aatd * regular use of alcohol within one month prior to screening * use of an investigational agent or device within 30 days prior to dosing or current participation in an investigational study involving therapeutic intervention * use of illicit drugs within 1 year prior to screening note: additional inclusion/exclusion criteria may apply, per protocol
excitatory prefrontal weak current stimulation in vegetative patients

Conditions: Disorder of Consciousness; MMN; Modification of Cognitive Status Indication; Anoxic Brain Damage; Trauma, Brain; Vegetative State; EEG; Paroxysms, Occipital, Epilepsy of Childhood; Cortical Atrophy

Summary: in response to "conscious" eeg findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious eeg activity (as well as standard clinical overt measures) and neuroplasctic propensity (i.e., changes in eeg spectral power synchronization values following tdcs intervention) in vegetative-state patients receiving repetitive transcranial direct current stimulation (tdcs) treatment over frontal motor areas for a period of two weeks. in support of this approach, a recent tdcs study with vegetative and minimally conscious patients implied that a twenty minutes anodal stimulation (i.e., excitatory stimulation) to the left dorsolateral prefrontal cortex (dlpfc) significantly increased crs-r scores versus sham (placebo: non-active stimulation) stimulation condition. it was noted that this tdcs effect was more pronounced in minimally conscious state patients versus vegetative state patients excluding effects of chronicity or etiology. thus, the investigators in this study suggested that tdcs could be effective in improving cognitive recovery in severely brain-injured patients. however, their findings would benefit neural activation correlates that could support their conclusion regarding the effectiveness of this type of non-invasive intervention in promoting neurocognitive recovery. most importantly, tdcs is safe for use in humans, has no adverse effects, is considered the most non-invasive transcranial stimulation method because it uses extremely weak currents (0.5 to 2 ma), and, is known to only temporarily shift the neuron's membrane potential towards excitation/inhibition. in regard to the method's potential to induce functional recovery in vegetative state patients, recent clinical studies indicate that tdcs could counteract the negative effects of brain damage by influencing neurophysiological mechanisms, and is likely to contribute to the "formation of functionally meaningful connections and the maintenance of existing pathways" .


Eligibility criteria:
inclusion criteria: * anoxic brain damage/tbi/cva/progressive dementia/encephalopathy * vegetative state patients or minimally conscious state according to crs-r criteria * ages 18 to 90 * consent for participation in clinical study (e.g., informed consent) by legal guardian of patients. exclusion criteria: * intracranial metal implants * implanted devices that may be affected by tdcs (pacemaker, medication pump, cochlear implant, implanted brain stimulator) * active medical condition that would preclude medical stability for the study, including significant ecg abnormalities, cardiac arrhythmia, uncontrolled high blood pressure * participation in other research studies
comparison of the effectiveness of erector spina plane block and transforaminal anterior epidural injections

Conditions: Lumbar Disc Herniation; Radiculopathy Lumbar

Summary: low back pain is one of the leading causes of disability and its social burden and economic cost are quite high. the lifetime prevalence in the population is frequently reported between 40% and 70%. although there are many reasons that can lead to low back pain, radicular pain, which develops mostly secondary to lumbar disc hernia, is one of the most common pathologies. epidural corticosteroid and local anesthetic injections are an important treatment option in the treatment of lumbar radicular pain that does not respond to conservative methods. epidural injections; includes transforaminal, interlaminar and caudal approaches. the advantage of the transforaminal approach is that it allows access to the anterior epidural area, which is the region of pathology, and that it can spread to the target specifically around the inflamed nerve roots. the standard imaging technology used for steroid injections with this approach is fluoroscopy. however, the aforementioned approaches carry the risk of dural puncture, epidural hematoma, epidural abscess, nerve damage, paralysis and many complications. in addition, radiation exposure is another problem. it may be possible to avoid a significant part of these risks by applying interfacial blocks used in regional anesthesia and postoperative pain control in the lumbar region. recently, erector spina plan block (espb), an interfascial block technique, has been frequently applied under ultrasound (us) guidance as an alternative method to conventional paravertebral block. investigators also frequently refer to this procedure in the clinic for patients with lumbar radicular pain. in the literature, there are case reports of lumbar espb applied to patients with radicular pain due to disc herniation. beyond case-level reports, there is no clinical study investigating the efficacy of this procedure technique for applications in the lumbar region. starting from here, the aim of this study is; investigators determined to compare the efficacy of erector spina plane block and transforaminal anterior epidural steroid injections in patients with radicular pain due to lumbar disc herniation.


Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * radicular low back pain * failure to respond to conservative treatments * single level lumbar nerve root compression due to disc herniation * agree to participate in the research exclusion criteria: * patients younger than 18 years and older than 65 years * those with non-radicular low back pain * those with nerve root compression due to reasons other than disc herniation * those with modic type-1 changes in lumbar mri * those with spinal stenosis or spondylolisthesis * those diagnosed with spondylodiscitis * pregnant * those with inflammatory rheumatic disease * patients whose use of non-steroidal anti-inflammatory drugs is contraindicated (renal failure, bleeding disorders, etc.)

Keywords: lumbar transforaminal epidural injection erector spinae plane block
is a single daily session combining hs + physio sufficient to obtain long-term clinical benefits in bronchiectasis?

Conditions: Bronchiectasis; Airway Clearance Impairment

Summary: the present study will aim to find out whether a home treatment in people with bronchiectasis consisting of a single daily session to facilitate expectoration (combining nebulization of hypertonic saline (hs) at 6% followed by airway clearance techniques) is at least as effective as performing two sessions per day following the same process in each of the sessions, during a period of 6 months.

a non-inferiority randomised clinical trial (single-blind) will be conducted. at least 50 participants will be recruited from the outpatient clinics of the hospital clinic in barcelona and the clinical university hospital in zaragoza. the experimental group will nebulize once/day the hypertonic saline (hs) solution followed by airway clearance exercises (15 min) for 6 months. the control group will follow the same procedure, but the frequency of the sessions will be twice a day (reference as usual clinical practice). the main study outcomes will be: (1) cough severity (primary endpoint), symptoms and quality of life; (2) functional exercise capacity; (3) time to first exacerbation and total number of exacerbations; (4) indirect measures of mucociliary transport (rheology and concentration of solids in sputum samples); (5) inflammatory parameters; (5) tolerance, safety and adherence to treatment. measurements will be taken at baseline (prior to randomization), at 1 month, 3 months, and 6 months. finally, hypothesis testing will be performed using a linear mixed model (2x3) of repeated measures, establishing a priori a margin of non-inferiority.

Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. a total score less than 16 on the leicester cough questionnaire 3. chronic daily expectoration over at least 3 months 4. being in a period of clinical stability during the previous 4 weeks 5. presenting a forced expiratory volume in 1 second (fev1) value greater than 40% of predicted or \>1 l 6. obtaining informed consent. in addition, all participants will have had to satisfactorily pass the tolerability tests, which will be performed twice: i) on the first day; ii) and the following week. exclusion criteria: 1. having received nebulised mucoactive treatment during the previous year 2. frequent haemoptysis (≥ 2 times/month) 3. diagnosis or suspicion of cystic fibrosis by genetic study or sweat test 4. being under active treatment for nontuberculous mycobacteria (ntm)

Keywords: airway clearance techniques hypertonic saline hyperosmolar agents oscillating positive expiratory pressure
upper limb task-oriented rehabilitation with robotic exoskeleton for hemiparetic stroke patients

Conditions: Cerebrovascular Accident (CVA); Chronic Disease; Stroke Rehabilitation

Summary: the aim of this study is to evaluate the effects of an assisted rehabilitation treatment through a robotic exoskeleton device on the functional recovery in a group of patients with hemiparesis from lesion of the first motor neuron (post-stroke), compared with a group of patients subjected to a conventional rehabilitation treatment. the patients enrolled in the study are chronic stroke injured with right hemiparesis of moderate to severe degree, by the system injury pyramid, never undergoing rehabilitation treatment with robots.


Eligibility criteria:
inclusion criteria: * diagnosis of a first-ever left hemisphere ischemic or hemorrhagic stroke at least 6 months prior to entry into the study; * minimum ability for shoulder humeral elevation; * upper-extremity motor function fugl-meyer (fm) score ≥ 15(out of 66); * absence of neurological or muscular disorders that interfere with neuromuscular function; * absence of severe cognitive deficits that would limit patients' ability to complete the study; * minimum score of 2 in the modified ashworth scale; * not participating in any experimental rehabilitation or drug studies at the same time * no previous experience with robotic treatments.

Keywords: robotics [h01.671.293.643] exoskeleton device [e07.341] rehabilitation research [h01.770.644.145.472] physical and rehabilitation medicine [h02.403.680] exercise therapy [e02.779.483] patient outcome assessment [n05.715.360.575.575.399]
assessing the reliability of self-reported hepatitis b vaccination status in outpatients: evaluation of individuals born in france and consulting at the cegidd in saint-denis.

Conditions: Hepatitis B; Vaccination; Health Knowledge, Attitudes, Practice; Serologic Tests; Ambulatory Care; Public Health

Summary: this study aims to find out whether people accurately know their hepatitis b vaccination status. it focuses on individuals born in france who visit a sexual health clinic (cegidd) in saint-denis. during the consultation, each person is asked whether they think they are vaccinated against hepatitis b. then, a blood test is done to check if they really are. the goal is to see how often people's answers match their actual medical status. the study also looks at factors like age, gender, education level, and whether they have a regular doctor to understand who is more likely to be unsure or mistaken about their vaccination status. about 200 participants are expected to take part.


Eligibility criteria:
inclusion criteria: * patients born in france. * consulting at the cegidd of delafontaine hospital in saint-denis. * requiring a hepatitis b serology test. exclusion criteria: - patients with a history of past hepatitis b infection.
positional release technique in patients with unilateral subacute trapezitis

Conditions: Cervical Spine Disease

Summary: to assess the effects of positional release technique to improve the cervical range of motion, relieve pain and function in the patient with unilateral subacute trapezitis.

trapezius pain is the most common muscular pain due to increased stress which results in trapezitis. the trapezius muscle is postural muscle diamond shape highly susceptible to overuse. it helps in extension, neck rotation, and side bending. trapezitis is frequently caused by bad posture, watching tv or working on computer for a long and use of thick pillo. passive rom may be painful and restricted due to protective spasm in muscle. this study will be a randomized controlled study and will be conducted in met life rehablitation center lahore. the study will be completed within the time duration of six months . consecutive sampling technique will be used to collect the data. the sample size of 44 patients will be taken in this study to find the effect of positional release technique in subacute unilateral trapezitis. patient will be divided into two groups. mayoficial release therapy and ultrasound will be given to both groups as a baseline treatment. (group a will be treated with positional release technique, mayofascial release technique and ultrasound while group b will be treated with mayofascial release technique and ultrasound). all measurements will be taken at baseline and at the end of 2nd week.each group will be given 3 sessions per week for 2 weeks. neck disability index will be used to measure function, numeric pain rating scale will be used to measure pain intensity and goniometer will be used to measure cervical lateral flexion and extension and rotation range of motion. data will be analyzed on spss 25.

Eligibility criteria:
inclusion criteria: * pain with less than 3 months duration * subjects of sub- acute trapezitis with trigger points * taut band palpable in upper trapezius muscle * excruciating spot tenderness at one point along the length of the taut band of the upper trapezius muscle * restriction in cervical lateral flexion when measured * pain increased by elongating (stretching) the trapezius muscle. exclusion criteria: * traumatic neck injury * fracture of cervical vertebras * cervical spinal cord compromise * cervical radiculopathy * spondylolisthesis of the cervical spine * a history of heart disease or the presence of a pacemaker

Keywords: positional release therapy trapezitis subacute, pain cervical rom