Kornimate/medical-research-clean huggingface dataset:
immediate treatment outcomes of b-cpap vs oxygen therapy in preterm babies presenting with rds at kcmc

Conditions: Respiratory Distress Syndrome in Premature Infant

Summary: bubble - continuous positive airway pressure (cpap) has been reported to be effective, cheaper, simpler and more accessible compared to mechanical ventilator and surfactant treatment for preterms with respiratory distress syndrome in the neighbouring countries. this study aims to implement and determine the effectiveness of bcpap and its immediate outcomes compared to oxygen therapy in preterm babies presenting with respiratory distress syndrome (rds).

effective treatment of preterm babies with rds requires exogenous surfactant and/or mechanical ventilation but these are of limited availability in developing countries. bcpap is generated by exhalation against a constant opening pressure that produces positive end-expiratory pressure. this in-turn helps in maintaining lung volume at the end of expiration, preventing atelectasis, improving oxygenation, reducing respiratory fatigue and eventually preventing respiratory failure. bcpap (rice 360◦c low cost bcpap device) consisting of 3 components: : (i)an air compressor connected to an oxygen concentrator with a gas flow fate of 3-4 l/min; (ii) a nasal interface (short nasal prongs) connecting the baby's airway to a two limb circuit i.e the inspiratory limb connected to the bcpap machine and the expiratory limb connected to the water bottle and; (iii) an expiratory limb with the distal end submerged 6 cm in water to generate an end expiratory pressure at the neonatal unit at kilimanjaro christian medical center (kcmc), the standard of care for preterm babies with rds is receiving oxygen therapy via nasal prongs from oxygen cylinders.

Eligibility criteria:
inclusion criteria: * all preterm babies (\ 60breaths /min, intercostal and subcostal recessions, nasal flaring, grunting and cyanosis) exclusion criteria: * preterm babies with birthweight less than 1kg (bcpap machine can only be used in babies with body weight of 1-10kg) * congenital malformations (cleft palate and lip, tracheal esophageal fistula and diaphragmatic hernia) * mothers who refused to consent
the effectiveness of a mobile interactive supervised therapy (mist) intervention for improving adherence to hiv medication

Conditions: HIV-infection/Aids

Summary: a total of 40 hiv infected patients will be randomly assigned into intervention or control group. participants in the intervention group will use an smart phone application for two months. participants will receive reminder notifications and use the app to take and send videos of themselves taking the pill(s), uploaded videos will be centrally reviewed by a study nurse . control group participants will receive standard care. antiretroviral therapy adherence will be measured by self-report, pill count, and smart bottle as well as the app. participants' perceptions of app using experience will be recorded via face to face interview.


Eligibility criteria:
inclusion criteria: * age ≥ 21 * hiv infection diagnosis confirmed by western blot * taking a once daily regimen of hiv medications * able to take pills orally * willing and able to give informed consent exclusion criteria: * inability to operate a smart phone * active tuberculosis infection requiring treatment during study (due to additional challenge posed to adherence that may confound the assessment of hiv adherence) * substance use * visual or hearing impairment * cognitive impairment

Keywords: mobile app hiv-infections medication adherence
controlled active motion vs early passive mobilization for flexor tendons repair

Conditions: Flexor Tendon Rupture

Summary: a randomized controlled trial tends to compare 2 rehabilitation approaches - early passive mobilization (epm) and controlled active motion (cam) - that are commonly used in the treatment of post-surgical flexor tendon repair of the hand

a randomized controlled trial tends to compare 2 rehabilitation approaches commonly used in the treatment of post-surgical flexor tendon repair of the hand. in this study, the authors try to fill the gap in the literature regarding the more effective approach. the comparisons between both approaches were scarce in previous literature. participants will be randomly allocated to one of two treatment groups: early passive mobilization (epm) using a modified kleinert protocol or controlled active motion (cam) using a modified duran technique (n=20). patients were assessed at baseline and then at the 6th and 12th weeks of interventions to quantify total active motion (tam) of the proximal and distal interphalangeal joints using goniometry, and grip strength with dynamometry. the disability level will be assessed using the disabilities of the arm, shoulder, and hand (dash) questionnaire.

Eligibility criteria:
inclusion criteria: * males or females * between 25-50 years * post-surgical repair of the flexor digitorum profundus (fdp) and superficialis (fds) tendons of a single-digit * the case should be recent (2-3 days post-surgical) exclusion criteria: * age below 25 or above 50 * a systemic disease affecting hand joints such as rheumatic arthritis * thumb flexor tendon repair will be excluded * chronic cases * concurrent injuries such as phalangeal fractures, joint injuries, or significant skin loss
augmented reality and treadmill training after traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: up to 40 participants will be enrolled in this study in order to obtain complete data on 30 participants. the investigators will be assessing if augmented reality in combination with treadmill training is safe and feasible to use in the clinical environment with participants who have chronic tbi and if there is a signal of effect that this intervention may be more beneficial than treadmill training alone or standard of care.


Eligibility criteria:
inclusion criteria: * sustained a tbi requiring inpatient rehabilitation * \> 1 year post tbi * 18-65 years of age * not currently participating in any other research study to address balance and gait impairment * not currently participating in physical therapy * ambulates with minimal assistance and/or assistive device * self-report of ongoing balance deficits and mobility deficits * score of 75 or below on cb\&m * no history of other neurological disorders affecting balance * no seizures within the last year * no history of psychiatric disorder requiring hospitalization * ability to follow directions and complete standardized instructions exclusion criteria: - no pregnant or lactating females (potential female participants will be informed that risks to pregnant or lactating females are unknown; then they will be asked if they are pregnant or lactating, or if they could be pregnant. if there is any uncertainty, they will not be included in the study).
early detection of health deterioration in elderly patients after hospitalization for heart failure decompensation

Conditions: Heart Failure

Summary: digital biomarkers extracted by ambient sensor signals are a promising tool for early detection of health deterioration in the setting of remote patient management of heart failure patients.the primary objective of the study is to evaluate new digital biomarkers as predictors of impending heart failure decompensation. secondary objectives are (1) outcome assessment (re-hospitalizations, cardiovascular death, all-cause death), (2) quality of life and (3) system user satisfaction (sus)


Eligibility criteria:
inclusion criteria: * admitted to hospital for worsening hf * age ≥ 70 years * lvef \< 50% and need of diuretics * nyha ii or iii * living alone * willing to participate with informed consent. exclusion criteria: * major depression (phq 9-score \>9) * being on hemodialysis * had been admitted to hospital for any reason within 7 days before hf decompensation. * patients with a left ventricular assist device * coronary revascularization or cardiac resynchronization therapy implantation within 28 days before the index event of hf decompensation or have been scheduled for such interventions.
predictive factors of obesity-hypoventilation syndrome (ohs) among obese subjects- etude cohypob -

Conditions: Obesity-hypoventilation Syndrome; Nocturnal Alveolar Hypoventilation

Summary: investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (ohs) in obese subjects


Eligibility criteria:
inclusion criteria: * obese volunteer subject (bmi\> 30 kg/m2) * adults of either sex * social security affiliation * written informed consent exclusion criteria: * confirmed ohs at baseline defined by a daytime hypercapnia with paco2\> 45mmhg * any cause of chronic respiratory failure other than obesity such as copd, chest deformation, phrenic nerve paralysis, pulmonary fibrosis, neuromuscular disease, a history of mutilating thoracic surgery ... * obstructive ventilatory defect with fev1/ fvc \<70% post-bronchodilator * long term oxygen therapy, noninvasive ventilation, continuous positive airway pressure * any serious illness involving life-threatening within 3 years after inclusion * drug or alcohol abuse * pregnancy

Keywords: ohs
gastric ultrasound in tube fed intubated patients

Conditions: Critical Illness

Summary: this study will use point of care (poc) gastric ultrasound to confirm that nasojejunal tube (nj) feeds result in minimal to no gastric content and therefore are low risk for aspiration and should be allowed at the very least to decrease the time that enteral feeds need to be held prior to a procedure or if they need to be held at all. this would allow critically ill children to receive the nutrition that they need to heal for longer periods of time. using ultrasound would also potentially eliminate the need for exposure to x-rays to confirm tube placement. most icus have a poc ultrasound machine so this would be any easy tool to access to improve patient care.


Eligibility criteria:
inclusion criteria: * all picu patients intubated \< 7 days that are receiving nj or ng feeds exclusion criteria: * patients that cannot be moved * patients with significant gi conditions affecting motility * patients intubated for more than seven days
study of oral upadacitinib to assess change in disease activity in adult participants with ulcerative colitis

Conditions: Ulcerative Colitis

Summary: ulcerative colitis (uc) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).this study will assess how effective upadacitinib is in treating uc. upadacitinib (rinvoq) is an approved drug for treating uc. approximately 400 adult participants who are prescribed upadacitinib by their physician in accordance with local label will be enrolled in germany, austria and switzerland. upadacitinib will be administered in accordance with the terms of the local marketing authorization, and treatment of participants will be determined solely by the investigator. participants in the study will be followed for up to 2 years. there will be no additional burden for participants in this trial compared to their standard of care. participants will attend regular visits during the study at a hospital or clinic and only data which are routinely collected during a regular visit will be utilized for this study.


Eligibility criteria:
inclusion criteria: * participants with an endoscopically confirmed diagnosis of active moderate to severe ulcerative colitis (uc). * participants initiating upadacitinib (upa) at the investigator's discretion as part of their routine clinical care; the decision to administer upa must be made prior to and independent of documentation for the study and according to the approved local label. * participants able to understand and communicate with the investigator and comply with the requirements of the study. * participants willing to continue with study documentation after cessation of upa. exclusion criteria: * participants with any contraindication to upadacitinib (upa). * participants previously exposed to a janus kinase (jak) inhibitor.

Keywords: ulcerative colitis uc upadacitinib upa rinvoq
t cells response to sars cov 2 peptides

Conditions: Covid19; Corona Virus Infection

Summary: the analysis method described in this protocol is a novel simple plausible immunological approach which is non-invasive, high throughput, real-time quantitative monitoring of metabolic activity (ma) profiles of fresh peripheral blood mononuclear cells (pbmc) in response to various reagents at different concentrations. the purpose of this study is to evaluate the t cells reactivity to sars cov 2 immunogenic selected peptides by metabolic activity method in convalesce and healthy individuals and to compare it with antibody response (elisa) and clinical information

this is a prospective, four groups, open, comparative, controlled study. a total of 400 completed, evaluated subjects will be enrolled in this study. main study measures: reactivity of t cells to selected sars cov-2 peptides by ma test and igg antibody response to sars cov-2 by commercial elisa test. study procedures: * screening * informed consent signing * medical history review * blood collection. * ma test and elisa test will be performed at savicell's laboratory site.

Eligibility criteria:
inclusion criteria: * all recruited subjects are between 18 to 90 years old. * all recruited subjects read the informed consent and then signed the informed consent. * all recruited subjects filled out the questionnaire form exclusion criteria: * subject has active infection or inflammation determined clinically at screening. * subject is currently treated with concomitant medication related directly or can affect the immune system as steroids. * subject has impaired judgment. * known positive hiv, hepatitis b, or hepatitis c, autoimmune disease. * known history of a significant medical disorder, which in the investigators' judgment contraindicates the patient's participation. * drug or alcohol abuse * subject is participating in any other clinical trial for drug investigation within 10 days prior sample collection

Keywords: cov-19 t cells cov-2 peptide
radiofrquency ablation combined with cytokine-induced killer cells for the patients with cervical cancer

Conditions: Cervical Cancer

Summary: the purpose of this study is to determine whether combining of radiofrequency ablation (rfa) and cytokine-induced killer cells (cik) transfusion can prolong survival of patients with cervical cancer.

the primary objective is to evaluate whether rfa followed by cik transfusion can prolong survival of patients with cervical cancer.

Eligibility criteria:
inclusion criteria: * they were systematic reviews based on randomized controlled trials (rcts). they were phase ii rcts comparing chemotherapy with other systemic therapy agents or with no further treatment for recurrent, metastatic, or persistent cervical cancer. they reported at least one of these outcomes: complete or partial response rate, overall or progression-free survival rate, adverse effects, or healthrelated quality of life (rcts reporting on heterogeneous populations-for example, women at a range of disease stages-were included if results were given separately for patients with recurrent, metastatic, or persistent cervical cancer). exclusion criteria: * studies evaluating the role of radiotherapy administered with chemotherapy, or second- or subsequent-line therapy options.
concurrent single gene and 24 chromosome aneuploidy preimplantation genetic diagnosis (pgd)

Conditions: Any Single Gene Disorder (Cystic Fibrosis, Tay-Sachs)

Summary: gene security network has developed a novel technology called parental supporttm (ps) which is used for preimplantation genetic screening/diagnosis (pgs/d) during in vitro fertilization (ivf). this technology allows ivf physicians to identify embryos, prior to transfer to the uterus, which have the best chance of developing into healthy children. the purpose of this study is to validate clinical use of ps to detect specific genetic mutation(s) known to cause severe inheritable diseases in embryos produced by at-risk couples. this may be done while simultaneously testing these embryos for aneuploidy. this study will allow for first of its kind commercial pgs/d testing to detect disease-associated genetic mutations together with aneuploidy screening.


Eligibility criteria:
inclusion criteria: * couple (mother and father)at risk to have a child with a single gene disorder (e.g. cystic fibrosis, tay-sachs, sickle cell anemia) * able to provide laboratory report from commercial clia certified laboratory confirming presence of disease associated mutation in mother and/or father * couple planning to go through ivf and desiring pgd for the specified mutation * father (male) willing and able to provide sperm sample * maternal (female's) age \<40 years (e.g., 39 or younger) * cvs/amnio planned once the pregnancy occurs; willing/able to provide amnio/cvs sample for confirmatory testing or provide test results of confirmatory testing performed by an external clia certified laboratory. * fsh \<10 (fsh = follicle stimulating hormone. fsh is an indicator of egg quality and rough predictor of egg stimulation success. fsh is routinely measured by the ivf center prior to beginning an ivf cycle.) exclusion criteria: * couples without prior documentation of genetic mutation as specified above * adult couples where the male partner is not willing, able, or available to provide a semen sample. * maternal age \>=40 years * couple unwilling to have amnio/cvs

Keywords: preimplantation diagnosis
telithromycin: in the treatment of acute exacerbation of chronic bronchitis in adult outpatients with copd

Conditions: Bronchitis, Chronic

Summary: non-inferiority efficacy of telithromycin versus azithromycin


Eligibility criteria:
inclusion criteria: * adult outpatients, either sex, aged 45 years or older. * patients with a documented history of chronic bronchitis with a basal fev1 \ 35% made in the previous 12 months and who had had at least one or more aebc in the previous year and with fev1/fvc \<70% (lung function tests made in the previous 12 months). * patients with a clinical diagnosis of acute exacerbation of chronic bronchitis presumably due to bacterial infection based on all of the following signs and symptoms of aecb: increased sputum purulence, and at least 1 of the 2 following signs and symptoms (increased dyspnea, increased sputum volume). * patients with negative chest radiography (posterior/anterior and lateral views) to rule out a pneumonia within 48 hours before initiation of study medication or at the latest 24 hours after initiation of study medication (it was necessary to not include patients with pneumonia associated with aecb). * patients with sputum specimens collected at inclusion for gram stain and bacteriological culture. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
omega-3 fatty acids supplementation in adhd

Conditions: ADHD

Summary: the overarching aim of the proposed study is to assess whether omega-3 fatty acids supplementation can augment the effects of methylphenidate in children with adhd. the investigators hypothesized that omega-3 fatty acids supplementation will be associated with improved adhd symptoms.


Eligibility criteria:
inclusion criteria: participants between ages 6 and 12 years who: 1. have been clinically diagnosed with adhd by a physician 2. meet the criteria of adhd-inattention, adhd-hyperactivity-impulsivity, or adhd-combined type as determined by the snap-iv (swanson, 1992) 3. are willing to participate in a randomized, double-blind, placebo-controlled trial, complete with written, informed parental consent, 4. are on stable dosage of methylphenidate treatment before the start of the study 5. are able to speak english or german exclusion criteria: 1. participants who are younger than 6 years old or older than 12 years old 2. those who have not been clinically diagnosed with adhd by a physician 3. those who did not meet the criteria of adhd-inattention, adhd-hyperactivity-impulsivity, or adhd-combined type as determined by the snap-iv (swanson, 1992) 4. those without written parental consent 5. those with brain pathology such as serious head injury, epilepsy, and intellectual disability (iq \< 70) 6. those with titrated dosage of methylphenidate before the start of the study 7. those on neurofeedback training, and/or psychosocial intervention addressing attention problems 8. those with known hypersensitivity to the imp under investigation 9. those who are unable to read and understand the parent/participant information 10. those receiving medications other than methylphenidate
validity and reliability of the turkish version of the mcmaster university head and neck radiotherapy questionnaire

Conditions: Quality of Life; Head and Neck Cancer

Summary: more than half of the patients with head and neck cancer are locally advanced patients. radiotherapy is the primary treatment option for many patients with stage iii and stage iv diagnosed with head and neck cancer. radiation often causes tissue reactions by increasing local symptoms of the tumor and adding new symptoms to them. the acute effects of radiation are pain and burns associated with mucosal irritations and skin irritations, the root smell of the necrotic tumor and damaged normal tissues, dry skin, skin irritation, pain and dryness of mucosal membranes, decreased appetite, loss of chewing and swallowing skills, and hoarseness. the aim of this study is to make the validity, reliability and cultural adaptation of mcmaster university head and neck radiotherapy inventory in turkish.

although there are various surveys in the literature that evaluate the quality of life of head and neck cancer patients, apart from the "mcmaster university head and neck radiotherapy questionnaire", there is no other questionnaire designed specifically for local advanced stage iii and stage iv head and neck cancer and treatment of specific morbidity at a certain time. patients in these stages often have difficulties in oral communication, nutritional disorders and loss of chewing and swallowing skills leading to dehydration, bad mouth odors, appearance problems affecting social and family life, and often significant morbidity including severe pain symptoms.

Eligibility criteria:
inclusion criteria: * voluntarily accepting to participate in the study * patients whose native language is turkish * undergoing or receiving radiotherapy treatment * at least 3 weeks have passed since the beginning of radiotherapy exclusion criteria: * the patient does not have sufficient functions of bone marrow, liver and kidney * to have scored less than 70 from karnofsky performance scale
clinical effectiveness of osteopathic manipulative treatment in chronic migraine

Conditions: Migraine

Summary: the aim of the present study is to determine the extend to which omt is effective on a sample of subjects affected by migraine evaluated using the headache impact test (hit-6) questionnaire.


Eligibility criteria:
inclusion criteria: * aged between 18 and 60 years old * chronic migraine exclusion criteria: * secondary forms of headache, * chronic illness, * psychiatric illness, * post-menopausal women

Keywords: osteopathic manipulative treatment migraine