Kornimate/medical-research-clean huggingface dataset:
health benefits of an exercise program for adults with arthritis

Conditions: Arthritis; Osteoarthritis; Rheumatoid Arthritis

Summary: the primary goal of this study is to assess the effect of people with arthritis can exercise (pace), a community-based group recreational exercise program, on key arthritis-related health outcomes among adults with arthritis.

self-management is very important in chronic diseases, and promoting physical activity is a key public health strategy for arthritis management. although several exercise programs such as people with arthritis can exercise (pace) have been created to implement this strategy, none have sufficient scientific evidence supporting their effectiveness to promote the programs through public health avenues. the primary goal of this study is to assess the effect of pace(people with arthritis can exercise), a community-based group recreational exercise program, on key arthritis-related health outcomes. the primary goal of the study will be accomplished through an eight week randomized controlled trial conducted with 480 participants residing in eight urban or rural communities in north carolina. this project is designed to evaluate the effectiveness of the program in changing arthritis-related health outcomes such as pain, function and physical activity levels. the project will compare the eight week pace program to a control group. the specific objectives are as follows: (the aims have not been modified.) 1. to further review the pace conceptual framework and materials in order to develop a standardized pace protocol to be delivered in the study as well as to refine study measures. 2. to work closely with the carolinas af chapter to develop collaborative relationships with local health departments and key contacts in communities identified for pace implementation. 3. to recruit 480 individuals to participate in a randomized controlled trial of pace in eight communities and to implement the pace program. 4. to compare changes in key arthritis-related health outcomes between pace participants and controls over eight weeks (pace course time frame). 5. to determine longer-term benefits of the pace intervention by examining key arthritis-related health outcomes 3 and 6 months post completion of the intervention. 6. to conduct qualitative research among pace completers and non-completers to determine motivators and barriers to success, as well as to determine the acceptability and suitability of the program. 7. to formulate recommendations or modifications for implementation of the pace program.

Eligibility criteria:
inclusion criteria: * adults over age 18 * have some form of arthritis (examples: osteoarthritis, rheumatoid arthritis, lupus, fibromyalgia, gout, etc.) * be able to move independently without assistance * currently exercising less than 3 times per week exclusion criteria: * inability to walk without assistance * severe health condition where exercise is contraindicated

Keywords: exercise physical activity physical conditioning pain physical function
evaluation of long-term safety and efficacy of pregabalin in patients with partial seizures.

Conditions: Seizure Disorder, Partial

Summary: to determine long-term safety and efficacy of pregabalin in patients with partial seizures.


Eligibility criteria:
inclusion criteria: * must have met the inclusion criteria for preceding double-blind study * have received double-blind study medication and wish to receive open-label pregabalin. exclusion criteria: * cannot be pregnant or considering becoming pregnant during the course of the study. * cannot be receiving any concomitant medication that could alter the effectiveness of the pregabalin response or affect seizure frequency.
physical activity maintenance in stroke

Conditions: Stroke

Summary: it is essential that individuals living with stroke engage in physical activity to improve cardiovascular risk factors and reduce the risk of stroke (billinger et al, 2014). this objective of this study is to examine the effectiveness of an educational brochure that promotes exercise in people with stroke, combined with a motivational telephone support, on maintaining physical activity. fifty participants with stroke will be enrolled. this study will provide insight into implementing effective tools that are designed to help individuals with stroke maintain physically active behaviours in the long-term.

study design this is a 4-week randomized controlled trial consisting of two groups: 1) participants who receive an educational brochure regarding physical activity after stroke, combined with motivational telephone support (intervention group), and 2) participants who receive the educational brochure alone (control group). interventions participants in the control group will be asked to devote approximately 30 minutes of their time to this study over the course of 4 weeks, and those in the intervention group will be involved for a total of 85 minutes. 1. educational brochure (both intervention and control groups): the educational brochure, aerobic exercise after stroke, will be provided to all participants in the study. the brochure was created by researchers from the canadian partnership for stroke recovery and written for a stroke audience. it was designed to educate individuals with stroke about the benefits of aerobic exercise, exercise intensity, and provide a sample program. 2. motivational telephone support (intervention group only): motivational telephone support is an inexpensive way of supplementing the educational brochure for facilitating physical activity behaviors by establishing a personal connection and providing ongoing support and motivation. participants in the intervention group will receive a total of 4 phone calls that will take place at 1-week intervals. each telephone session will last approximately 15 minutes, where issues regarding ongoing physical activity, such as relapses and road blocks, will be addressed. also, ongoing motivation and support will be provided as needed to re-direct participants back onto the path of physical activity engagement. statistical analyses baseline participant characteristics will be analyzed using descriptive statistics. a two-way analysis on variance will be used to compare mean differences in physical activity and self-efficacy between the intervention and control group considering a group x time interaction

Eligibility criteria:
inclusion criteria: * completed the intervention arm of a previous trial (fit for function) * living in the community * not involved in active rehabilitation exclusion criteria: * musculoskeletal contraindications to exercise * unstable cardiovascular conditions * unstable medical conditions

Keywords: physical activity, brochures, telephone support, stroke
abuse and addiction in icu

Conditions: Substance Withdrawal Syndrome

Summary: investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (icu) admission on incidence of delirium and sedation requirements. study design: a prospective observational study, in a medical icu of a tertiary university hospital. methods: for all new icu admissions, a 1-page questionnaire including alcohol use disorders identification test (audit-c), smoking history and prior medication use was given to the patient or closest family members. delirium was assessed by trained icu nurses using intensive care delirium screening checklist and richmond agitation-sedation scale.


Eligibility criteria:
inclusion criteria: * patients who are older than 18 years of age * new patients admitted to medical icu for the 1st time during their stay in hospital exclusion criteria: * had history of stroke or other primary neurologic disease * gcs ≤ 8 prior to icu admission * transferred from other icu (except for emergency icu stay which is limited to less than 36 hours) * not registered within 24 hours after admission * refused to participate * if comatous state persists * delirium assessment is not possible due to newly developed neurologic disease, such as cerebral infarction * medical icu stay less than 24 hours * readmission to medical icu

Keywords: intensive care unit delirium substance withdrawal
aerosol therapy in obese copd patients.

Conditions: Chronic Obstructive Pulmonary Disease Moderate; Obesity

Summary: this study has the objective to clarify the factors that directly influence the effectiveness of inhaled drug deposition in obese patients with chronic obstructive pulmonary disease (copd) and suggest the use of high flow nasal cannula (hfnc) during their inhalation therapy.

this study has the objective to clarify the factors that directly influence the effectiveness of inhaled drug deposition in obese patients with chronic obstructive pulmonary disease (copd) and then formulate specific strategies to control the evolution of this disease. the suggested strategy in order to implement the aerosol therapy is the use of high flow nasal cannula (hfnc) during these patient´s inhalation therapy. it will consist in a cross-over clinical trial. the population will be composed by volunteers of both genders, aged between 45-70 years old. four distinct groups will be formed: obese participants without copd; obese participants with copd; non obese participants without copd; non-obese participants with copd.

Eligibility criteria:
inclusion criteria: healthy, non obese * no history of respiratory disease * non smokers * self declared sedentary * forced expiratory volume at first second (fev1) equal or higher than 80% of predicted * forced vital capacity (fvc) equal or higher than 80% of predicted; * fev1/fvc higher than 70% of predicted. * bmi lower than 30 kg/m2 healthy, obese * no history of respiratory disease * non smokers * self declared sedentary * forced expiratory volume at first second (fev1) equal or higher than 80% of predicted * forced vital capacity (fvc) equal or higher than 80% of predicted * fev1/fvc higher than 70% of predicted. * bmi equal or higher than 30 kg/m2 copd participants, non obese * ex smokers * clinical stability (six previous weeks) * fev1 lower than 80% of predicted. * fev1/fvc lower than 70 % post bronchodilator. * no cardiopulmonary diseases (self declared) * bmi lower than 30 kg/m2 copd participants, obese * ex smokers * clinical stability (six previous weeks) * fev1 lower than 80% of predicted. * fev1/fvc lower than 70 % post bronchodilator. * no cardiopulmonary diseases (self declared) * bmi equal or higher than 30 kg/m2 exclusion criteria: * difficulty to understand verbal commands * exacerbations during the study period

Keywords: aerosol therapy pulmonary scintigraphy upper airways anatomy high flow nasal cannula
french and european outcome registry in intensive care unit

Conditions: Intensive Care Unit Syndrome; Tracheal Intubation Morbidity

Summary: the purpose of this study is to identify within a cohort of icu patients admitted for severe illness those who are at risk of death in the year following the discharge from icu.

frog-icu is an epidemiological, observational, prospective, multi centric, cohort study designed for description, prognostic and evaluation. this trial includes as a first step a complete registry of patients admitted to the icu and as a second step, the outcome of the patients at 1 year after they have been discharged alive from icu. plasma and urine samples will be with drawn biomarkers measurements at admission and icu discharge. it is a multicentric study involving 1 center in belgium et 24 centers in france.

Eligibility criteria:
inclusion criteria: * adult patients hospitalized in icu * patients should have been intubated more than 24 hours * or treated with a positive inotropic agent for more than 24 hours (if not ventilated exclusion criteria: * age \< 18 years * pregnancy women * breast-feeding women * not affiliated with social security * dying man * end of life patient * traumatic brain injury (igcs \< 8) * ntbr * vegetative coma * transplanted for less than year * no french speaking patient * out of france resident * end of life decision during the following

Keywords: biological markers intensive care unit mortality quality of life cardiovascular
internet-based depression screening for college students

Conditions: Major Depressive Disorder

Summary: this study aims to determine whether using telecommunication tools, specifically web pages containing online screening instruments and real-time video chat, will be an efficient way to implement major depressive disorder screening among college students. the study also aims to determine if proactive depression screening and free online consultation with a psychiatrist will increase the rate of help-seeking among college students with mdd. eligible participants will complete a demographics survey and depression screening assessment online. those subjects who express suicidality or depressive symptoms will be offered the opportunity to complete a one-time psychiatric consultation with skype video-conferencing.


Eligibility criteria:
inclusion criteria: * all who consider themselves current undergraduate from massachusetts colleges are encouraged to participate.

Keywords: telepsychiatry mdd depression major depressive disorder skype college university
apixaban in subjects with peritoneal dialysis

Conditions: Chronic Renal Insufficiency; Peritoneal Dialysis

Summary: the primary objective of this study is to assess the pharmacokinetics of a single oral dose of apixaban (5mg) in participants with dialysis peritoneal versus participants with normal renal function.

participants with chronic renal disease treated with peritoneal dialysis and participants with normal renal function are hospitalized for three days.

Eligibility criteria:
inclusion criteria: * participant with 21\<bmi\<40 * french participant * participant able to consent * participant with social insurance * participant on peritoneal dialysis for at least 3 months with end-stage renal disease treated exclusion criteria: * participant with hypersensibility reactions to apixaban * participant with a history of major bleeding * participant already on anticoagulant * participant on non-stearoid anti-inflammatory at anti-inflammatory dosage \> 300 mg * participant on potent inhibitors of cyp 3a4 and p-gp * participant on inducers of cyp3a4 and p-sp * participant with moderate (child-pugh b) or severe (child-pugh c) hepatic impairment * participant receiving or having received antibiotic treatment within 14 days prior to study * pregnant or lactating women * participant with known hypersensitivity reactions to icodextrin * participant not supporting an intraperitoneal volume of 2 liters (only participant with peritoneal dialysis) * participant with "normal renal function" with glomerular filtration rate \< 90 ml/min
early intensive exercise to improve walking in children with spastic diplegia

Conditions: Spastic Diplegia

Summary: this is a randomized controlled trial comparing 3 months of intensive leg exercise to standard physiotherapy care for the improvement of motor function in the legs in young children with spastic diplegia.

children born prematurely are at risk of brain injury that can result in cerebral palsy(cp), most often affecting the legs, called spastic diplegia. current treatment is largely passive, including leg braces, repeated injection of a paralyzing agent (botox) in muscles that are abnormally active, and surgery as deformities occur. active, physical therapy for weak muscles is infrequent, occurring twice a month or less. yet, recent work with mammals show that early brain injury can be alleviated by intensive exercise therapy, but only while the animal is very young. building on the success with early, intensive therapy for children with perinatal (around birth) stroke, the investigators will apply intensive therapy for the legs in children with diplegia. children (8 mo - 3 yr old) will be randomly assigned to start treatment immediately or delay treatment for 3 mo. the delay period controls for improvement without treatment. these children will also receive treatment after the delay period. the therapy will be guided by physical therapists, and similar to the project on perinatal stroke. children who live beyond commuting distance from the centres will form a 3rd group, whose parents will be coached by therapists to train the child at home. this group will show whether parents can be as effective as a therapist. finally, when all children turn 4 yr old, they will be compared to other 4-yr-old children with the same diagnosis, but no training, to determine if there are long term benefits. the investigators anticipate that like the children with perinatal stroke, early intensive exercise will improve mobility, facilitate earlier and better walking, and that the effects will be enduring.

Eligibility criteria:
inclusion criteria: * children aged 8 mo - 3 yr old * evidence of periventricular white matter injury on diagnostic imaging * clinical evidence of spastic diplegia exclusion criteria: * born before gestational age of 25 weeks * birth weight \<1000g (to exclude confounds related to extreme prematurity and low birth weights) * mri evidence of diffuse injury to the cerebral or cerebellar cortex * uncontrolled epilepsy or infantile spasms in the past 6 months (contraindication for tms) * cardiovascular or musculoskeletal complications that preclude participation in intensive exercise * botulinum toxin (btx-a) injections in the last 6 months * predicted gmfcs 4 or 5

Keywords: cerebral palsy physical therapy rehabilitation
effect of pectin in chronic kidney disease patients ( stage 3 and 4 )

Conditions: Chronic Kidney Diseases

Summary: effect of pectin in chronic kidney disease patients

chronic kidney disease (ckd) is a serious global health problem leading to serious comorbidities, end-stage renal disease (esrd), and death from 1990 to 2016, the prevalence of ckd increased by 90% worldwide, which is closely tied to the increase in at-risk populations with diabetes mellitus (dm), hypertension (htn), and prediabetes . it is estimated to be around 9.1 to 13.4%. this means there are about 700 million to over 800 million cases of ckd worldwide. in 2017, ckd resulted in 1.2 million deaths and was the 12th leading cause of death worldwide . and in the same year, the estimated prevalence of ckd in egypt was 7.1 million individuals, which means 106 patients/1000 population . pectin, a class of heteropolysaccharides based on polygalacturonic acid, is a safe and non-toxic natural food additive recommended by the joint fao/who committee on food additives with no daily additive limit . pectin is mainly obtained from apple pomace, citrus peels and sugar beets, ancurrently, commercial pectin contains ≥65% gal-a (galacturonic acid). among the patients who tried to take the pectin, unexpectedly was found that the pectin had a significant effect on the rapid reduction of blood creatinine concentration in patients with chronic kidney disease. so, the authors followed up the physical examination indeces of chronic kidney disease patients who took the pectin .

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of ckd patients (stage 3 and 4) 2. age between 18 and 60 years 3. must be able to swallow tablets exclusion criteria: 1- end stage renal disease ( stage 5 ) 2 - patients with renal transplantation 3- pregnancy 4- presence of malignancy
refitting frequent replacement lens wearers into clariti 1 day and 1-day acuvue moist daily disposable spherical lenses

Conditions: Myopia

Summary: the objective of the study is to evaluate and compare the performance of somofilcon a to etafilcon a when worn on a daily disposable wear modality over a period of approximately one week.

the study is a prospective, double masked (investigator and participant), bilateral, randomized, cross-over dispensing study, which evaluates somofilcon a (test lens) and etafilcon a (control lens).

Eligibility criteria:
inclusion criteria: * subjects will only be eligible for the study if: 1. is at least 17 years of age and has full legal capacity to volunteer; 2. has read and signed an information consent letter; 3. is willing and able to follow instructions and maintain the appointment schedule; 4. habitually wears silicone hydrogel frequent replacement soft contact lenses, for minimum of 6-months; 5. is correctable to a visual acuity of 20/40 or better (in each eye) with the study lenses; 6. can be fit with study contact lenses with a power between - 0.50 and -10.00 ds; 7. demonstrates an acceptable fit with the study lenses; 8. habitually wears contact lenses for at least 8 hours per day, and willing to wear contact lenses for at least 12 hours a day in the study. exclusion criteria: * subjects will not be eligible to take part in the study if: 1. is participating in any concurrent clinical or research study; 2. has any known active\* ocular disease and/or infection; 3. has a systemic condition that in the opinion of the investigator may affect a study outcome variable; 4. is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable; 5. has known sensitivity to the diagnostic pharmaceuticals to be used in the study; 6. is pregnant, lactating or planning a pregnancy at the time of enrolment (verbal confirmation at the screening visit); 7. is aphakic; 8. has undergone refractive error surgery; 9. is an employee of the centre for ocular research \& education; 10. has participated in the beagle (ex-mktg-104) study.
peer-led digital health lifestyle intervention for a low income community at risk for cardiovascular diseases (mycardio-peer)

Conditions: Primary Prevention of Cardiovascular Diseases

Summary: the goal of this interventional study is to develop and assess the effectiveness of a peer-led digital health program (mycardio-peer) for primary prevention of cardiovascular disease (cvd) in a low-income community at-risk of cvd. the main questions it aims to answer are: * is mycardio-peer effective in improving knowledge, lifestyle behaviors and cvd biomarkers of a low-income community at-risk for cvd? * is there an association between mycardio-peer participants' adherence and satisfaction, with effectiveness and sustainability of the program? participants will attend the 8-weeks mycardio-peer program with their peer leaders, supplemented with face-to-face components. participants will then be followed up for another 12 weeks, during which peer leaders and researchers will have minimal contact with the participants. participants who have been allocated into the control group will receive printed documents with standard tips on dietary and lifestyle management for cvd, where they will be encouraged to maintain regular calorie intake and expenditure and perform regular exercise.


Eligibility criteria:
inclusion criteria: * mentally sound man/woman of at least 30 years old * monthly household income of less than rm3,710 or receiving government aid for low-income community * literate with a fair command of the malay language * have mobile device connected to the internet * willing to attend 8 weeks of intervention and be followed up for another 12 weeks during the maintenance phase. * have been confirmed to have a moderate or high risk for cvd based on the framingham general cvd risk score exclusion criteria: * pregnant, lactating or intend to become pregnant during the study period. * any other pre-existing conditions or severe complications that could compromise the ability to adhere to the study program. * enrolled in other studies.

Keywords: peer-led primary prevention cardiovascular diseases digital health lifestyle intervention peer support community