Kornimate/medical-research-clean huggingface dataset:
identification of novel targets for regulation of adipose tissue mass

Conditions: Obesity

Summary: the aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. the novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.


Eligibility criteria:
inclusion criteria: * participants of the optifast52 program * bmi \> 30 kg/m2 exclusion criteria: * rejection of informed consent by the participant

Keywords: patients with obesity (bmi > 30 kg/m2)
fermented wheat germ extract in women with ovarian cancer

Conditions: Ovarian Cancer

Summary: the main purpose of this pilot study is to test the safety, tolerability and quality of life in women who take fermented wheat germ extract (fwge), to determine if an active form of fwge can be detected in the blood, and determine whether short-term therapy with fwge has any effect on the tumor marker, cancer antigen 125 (ca-125).


Eligibility criteria:
inclusion criteria: * women with suspected epithelial ovarian, fallopian tube or primary peritoneal carcinoma scheduled to undergo surgical exploration with no prior treatment for the cancer. signs of ovarian cancer include, but are not limited to: an elevated cancer antigen 125 (ca-125), a complex pelvic mass, ascites, and carcinomatosis. these signs are not necessary for suspicion or enrollment in this protocol. * age \> 18 years and competent to give informed consent. * must have a eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 and a life-expectancy of at least 60 days. * adequate bone marrow function. * adequate renal function. * adequate hepatic function. * participants must sign an approved informed consent and authorization permitting release of personal health information. * women of childbearing potential must have a negative serum pregnancy test prior to the study entry and be practicing an effective method of birth control during the course of the study, in a manner such that risk of failure is minimized. exclusion criteria: * current use of fwge * known allergy to wheat, rice (contained in the placebo), orange or the sweetener, stevia. * potential participants who received neoadjuvant chemotherapy for ovarian cancer. * an upper gastrointestinal or other condition that would impair swallowing or absorption of oral medication. * any serious illness or medical condition that would not permit the patient to be managed according to the protocol, including, but not to limited, any the following: history of significant neurologic or psychiatric disorder (e.g., uncontrolled psychiatric disorders) that would impair the ability to obtain consent or limit compliance with study requirement; active uncontrolled or serious infection; active peptic ulcer disease. * uncontrolled hypertension defined as systolic greater than 180 and diastolic greater than 100.

Keywords: epithelial ovarian fallopian tube primary peritoneal carcinoma peritoneal ovary
effects of transcutaneous electrical nerve stimulation on breast surgery

Conditions: Breast Cancer Surgery; Transcutaneous Electric Nerve Stimulation

Summary: the aim of this randomized controlled trial was to evaluate the effects of transcutaneous electrical nerve stimulation (tens) on postoperative pain, lymphedema development, shoulder range of motion, and quality of life in women undergoing breast cancer surgery after neoadjuvant chemotherapy. the main questions it aims to answer are: does tens reduce postoperative pain? does tens prevent postoperative lymphedema? does tens increase postoperative shoulder range of motion? does tens improve postoperative quality of life? the researchers will compare the effects of tens after breast surgery with a control group. participants will be assessed for pain, lymphedema development, and shoulder range of motion before surgery, on the first day after surgery, at the first month after surgery, and at the third month after surgery. quality of life will be assessed before surgery, at the first month after surgery, and at the third month after surgery.


Eligibility criteria:
inclusion criteria: * those whose primary cancer tissue is breast * asa classification is between i and iii * having unilateral breast surgery exclusion criteria: * those with cardiac problems and those using a pacemaker * pregnant * cognitively impaired * disruption of skin integrity in the tens application area

Keywords: pain lymphedema mastectomy mobility limitation quality of life
phytomedicines versus hydroxychloroquine as an add on therapy to azythromycin in asymptomatic covid-19 patients

Conditions: Covid19

Summary: our previous work on plants has indicated significant antimalarial and antiviral activities. of these plants, two recipes are proposed for evaluation for covid-19. it is cinchona, an antimalarial and a combination of 4 plants with antiviral, antimalarial, antitussive and anti-inflammatory properties. the phase ii clinical trial, with three arms and at a rate of 77 patients per arm, received the approval of the national committee for ethics and health research. this is a non-inferiority test aimed at comparing the therapeutic impact in "add on" to azithromycin, phytomedicines versus hydroxychloroquine in asymptomatic covid-19 patients. after 10 days of treatment, viral clearance and symptom progression will be assessed on days 3, 6 and 14. clinical, paraclinical and laboratory tests will be performed throughout the 3-month trial. ethical and deontological considerations will be applied

all consenting subjects who meet the inclusion criteria will benefit from an individual file which will include data relating to general information, the complete clinical examination and the paraclinical examination. they are distributed randomly into three parallel groups, each arm having a different treatment modality. a balanced randomization by permutation block of 5 will be applied using the "randomizer for clinical trial" application developed by the company medsharing). laboratory examinations are carried out according to the procedures and method by laboratories accredited in guinea for the diagnosis of covid19. data is encoded, entered and processed using statistical software. the comparison between the three cohorts will be made using either the anova test for continuous variables or the chi-square test for categorical variables. the rate of change over time of virologic clearance, fever and other symptoms values as well as the differences for these rates between treatment arms will be tested using mixed-effects modeling. the biological samples will be stored at the biobank of the national institute of public health of guinea.

Eligibility criteria:
inclusion criteria: * eligible patients are adults with covid-19 confirmed by a positive pcr (polymerase chain reaction) test and without symptoms exclusion criteria: * any patient hypersensitive to hydroxychloroquine or under traditional herbal treatment in the two weeks preceding inclusion, * any patient with other acute or chronic illnesses such as heart failure, arterial hypertension, renal failure, hepatocellular failure, tuberculosis or unable to take the oral treatment; * any patient for whom one of the treatments under study is contraindicated according to the doctor's opinion. * pregnant women, * severe neurological manifestations

Keywords: treatment; clinical research
prosalute: community program for cardiovascular health

Conditions: Primary Prevention

Summary: the purpose of this study is to determine the efficacy and cost/effectiveness (change in cv risk factors and lifestyle vs costs) of prosalute as a new organizational model of primary cv prevention.

primary cardiovascular (cv) prevention programs in the healthcare place and community-based interventions have a variable impact on health at the population level. the largest benefit may be obtained by addressing high-risk, disadvantaged and traditionally hard-to-reach groups. effective actions include health promotion, timely screening of modifiable risk factors, application of evidence-based targets and interventions, broad access to heart-friendly environments/facilities and dissemination of favorable social norms. thus, community prevention is a multifaceted task that requires multidisciplinary collaboration. a suitable program should be tailored to the specific social context and make the most of local resources to improve access, adherence and continuity, as well as sustainability. prosalute is a new model of primary cv prevention for the prevalently low-income and multiethnic community of ponte lambro (n=3600 adults), the neighborhood where the coordinating hospital (centro cardiologico monzino, milan, italy) is located. under the coordination of a case manager (a nursing researcher) the citizens are involved in a prevention program, which is personalized (content and intensity) according to the individual global risk and specific risk factors. the citizens follow an individualized schedule of short-term specialist care. besides, the participants are "gently nudged" to make use of local resources that may contribute to sustain a healthy life-style (e.g. parks, gyms, social services, etc). moreover, public preventive events for the community are devised (e.g. healthy-cooking course, walking groups, etc) through a collaborative network with representatives of the neighborhood.

Eligibility criteria:
inclusion criteria: * live in milan at neighborhood of ponte lambro exclusion criteria: * patients with known atherosclerotic disease (secondary prevention) * severe diseases or disabilities that hinder the participation in the program

Keywords: cardiovascular diseases public health hypertension smoking hypercholesterolemia food habits exercise anxiety depression obesity diabetes
the impact of exercise training on functional capacity in heart failure

Conditions: Heart Failure With Preserved Ejection Fraction

Summary: the purpose of this study is to determine whether exercise training will improve functional capacity in patients with heart failure and preserved ejection fraction.


Eligibility criteria:
inclusion criteria: * clinical heart failure * preserved ejection fraction (\>50%) * stable clinically * new york heart association class ii-iii exclusion criteria: * unable to exercise * other debilitating or unstable disease limiting length of life * implanted pacemaker

Keywords: heart failure preserved ejection fraction
non-anesthesiologist administered propofol sedation for colonoscopy - a randomized clinical trial

Conditions: Digestive System Diseases; Colonoscopy Sedation

Summary: propofol is the preferred sedation for colonoscopy. there is debate on the safety of the administration of propofol by non-anesthesiologists, despite moderate quality evidence that support its' use. there is only one small trial of a direct comparison of propofol sedation by anesthesiologists versus non-anesthesiologists. our aim is to compare the incidence of sedation related adverse events, the procedural quality indicators, times (onset, recovery, discharge) and patient satisfaction between non-anesthesiologist administered propofol sedation (naap) sedation and anesthesiologist propofol sedation. a randomized clinical trial with the incidence of sedation related minor adverse events as primary endpoint will be conducted. secondary endpoints include procedure quality indicators, propofol dosage and patient satisfaction. a sample size of 330 subjects (2 arms of 165 patients) will be needed in order to obtain 90% power and a 5% significance level to exclude a 15% difference (15 - 30%) in adverse events incidence, estimated from our pilot experience. the sample size was adjusted for a 2% cross-over rate. informed and consenting patients undergoing colonoscopy examinations will be randomly assigned to one of two arms. one group will be sedated by an anesthesiologist according to a protocol of propofol mono-sedation. the other group will be sedated with propofol boluses, according to the european society of gastrointestinal endoscopy (esge) naap guideline, with a 3-man team consisting of one endoscopist, one endoscopy nurse and a sedation nurse, trained in naap and exclusively dedicated to sedation and patient monitoring.


Eligibility criteria:
inclusion criteria: * referred for elective colonoscopy as outpatients * must be able to provide the informed consent exclusion criteria: * american society of anaesthesiologists (asa) class \>2 * pregnant women * difficult airway predictors (more than 2 ou mallampati \>3) * allergy to propofol or its' components * iv drugs abuse

Keywords: colonoscopy sedation propofol non-anesthesiologist propofol administration
non-invasive screening for fetal aneuploidy

Conditions: Down Syndrome; Edwards Syndrome

Summary: the purpose of this study is to detect whole chromosome abnormalities in maternal blood.

the purpose of this study is to detect whole chromosome abnormalities on all chromosomes 13, 16, 18, 21, x and y, in the fetus through analysis of cell free and compound sample dna (cf dna and cs dna, respectively) in maternal blood. in addition, major deletions and duplications in chromosomes 1, 4, 5, and 22 will be detected.

Eligibility criteria:
inclusion criteria: * • subject is a pregnant woman 18-54 years of age at 8-22 weeks' gestation inclusive; * subject has additional risk indicators for fetal chromosome aneuploidy, including one or more of the following: * maternal age \> 34 years at the estimated date of delivery; * positive serum screening test suggesting fetal aneuploidy; * previous positive noninvasive cfdna test is acceptable * fetal ultrasound abnormality suggesting fetal chromosomal abnormality; * personal or family history of down syndrome or other chromosomal aneuploidy. * willing to provide written informed consent * willing to be re-contacted subsequently for additional information and/or testing if necessary. exclusion criteria: * subjects will not be entered into this study if they meet the following criteria: * fetal demise at the time of the blood draw; * previous specimen donation under this protocol; * unwilling or lacks the capacity to provide informed consent or to comply with study procedures; * currently under treatment for cancer * any history of autoimmune disease * any pelvic mass * previous history of radiation to pelvis * any history or current evidence of a twin demise at any gestational age.
the effect of controlled massage applied at birth on labor pain and duration and maternal satisfaction

Conditions: Massage

Summary: this study was carried out to determine the effect of controlled massage applied at birth on labor pain and duration and maternal satisfaction. the study was conducted as a randomized, controlled research. the research was conducted with 154 randomized pregnant women admitted to erzurum nenehatun obstetrics and maternity hospital between february-november 2019. the study consisted of 3 different groups: group a included the pregnant women who received routine hospital care (control group n=53), group b included the pregnant women who received midwife-controlled massage (n=50), and the group c consisted of the pregnant women who received self-controlled massage (n=51). it was determined that the controlled massage intervention that was applied in this study reduced labor pain, but it did not affect the duration of labor or the satisfaction levels of the women.

this study was conducted to determine the effects of controlled massage applied during labor on pain during labor, labor duration and maternal satisfaction. this was a randomized-controlled experimental study.the study was carried out with the participation of 154 randomly selected pregnant women at an obstetrics and gynecology hospital located in a province in the eastern anatolia region of turkey between february and november 2019.the study included three groups (a: control group, b: midwife-controlled massage group, c: self-controlled massage group). the data were collected using a "personal information form", the "visual analogue scale (vas)", the "verbal category scale (vcs)", a "partograph", an "individual-controlled massage follow-up form" and the "scale for maternal satisfaction in vaginal delivery (smsvd)".it was determined that the controlled massage intervention that was applied in this study reduced labor pain, but it did not affect the duration of labor or the satisfaction levels of the women. impact statement what is already known on this subject? labor pain and outcomes occurring during labor are known and expected situation. some nonpharmacological methods are applied to ensure that birth is easy and maternal satisfaction is high. what the results of this study add? there is no studies using thecontrolled massage. in our study, it was found that controlled massage is effective on labor birth. what the implications are of these findings for clinical practice and/or further research? our study suggested that midwives and pregnant women could practice controlled massage to reduce labor pain.

Eligibility criteria:
inclusion criteria: * having at least a primary school degree * not having a communication problem * having a primiparous term pregnancy (38-42 weeks) * not having an obstetric risk * being in the latent phase of labor (dilation 0-3cm) * having no contraindications for massage exclusion criteria: * being multiparous * having a high-risk pregnancy * being in the active or transitional phase of labor * having a contraindication to massage

Keywords: birth, labor duration, labor pain, massage, satisfaction
interaction of inflammation, taste perception and preferences as a function of physical activity and body composition

Conditions: Taste, Altered

Summary: the aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. the focus will be on sweet taste and the perception of fat. a non-invasive, observational study design will be used.

this study adresses the question of whether there is a connection between low-grade inflammation caused by physical activity and a change in taste perception and preference for the sweet taste. the taste perception, preference behavior and inflammation in athletic and healthy non-athletic subjects using an observational study design is investigated. the hypothesis is that athletic test subjects, compared to healthy, physically inactive subjects, show increased inflammation values, in the range of a low-grade inflammation, and that this results in a lower sensitivity and increased preference for sweet taste. the primary parameters to be investigated are a possible correlation between the level of physical activity physical activity or body composition and the recognition threshold for the sweet taste as well as the preference. in addition, a correlation between the concentration of tnf-α and il-6 in saliva sweet recognition threshold and sweet preference will be investigated. secondary parameters to be analyzed are the preference for fatty substances, the perception threshold for the perception threshold for the fatty taste, taste receptors in saliva for the sweet and fatty taste, the concentration of 8-epi-pgf2α in the urine as a marker for oxidative stress, and the number of fungiform papillae on the tongue are determined.

Eligibility criteria:
inclusion criteria: * healthy * non-smoking * normal taste and smell perception exclusion criteria: * pregnancy or breast-feeding * regular smokers * regular intake of medication * metabolic diseases that require drug therapy * ageusia or anosmia * alcohol or drug addiction * intake of antibiotics within the past 2 months * vegan diet * viral or bacterial infection wihtin the past three weeks

Keywords: taste inflammation physical activity sweet preference
your voice; impact of duchenne muscular dystrophy (dmd) on the lives of families

Conditions: Duchenne Muscular Dystrophy; Burden, Dependency; Disability Physical; Disease Management; Impairment; Rare Diseases

Summary: the purpose of this study is to improve the understanding of the treatment goals that a person with duchenne muscular dystrophy (dmd) or the caregiver may be most interested in, based on the severity of the person's disease. data will be collected by online survey when the participant accepts the study invitation ("rsvp questionnaire") and telephone interview on the functional burden and self-identified treatment goals from the perspective of people with dmd and their caregivers. interviews will be analyzed to help identify things important to duchenne families to measure in clinical trials and to inform the selection of key concepts of interest and development of future clinical outcome measures, including observer reported outcomes/patient reported outcomes. the study will be conducted in the united states and will enroll between 45 and 120 participants 11 years or older living with dmd as well as their caregivers. the time commitment for the online survey and the telephone interview is about one hour. it is anticipated that the entire study will be completed within one year.


Eligibility criteria:
inclusion criteria: 1. participant must be a person with dmd who is 11 years or older or the parent/legal guardian of a person with dmd who is under the age of 18 years. 2. confirmed diagnosis of dmd with written proof of disease provided 3. resident of the u.s. 4. able to read, write and communicate in english 5. able to grant informed consent 6. willing to participate in a 45 minute telephone interview 7. ability to view or receive a document from the interviewer before or during the interview (web browser, ability to receive a text, fax or document by mail) exclusion criteria: 1. inability to meet any of the inclusion criteria

Keywords: duchenne, dmd