Kornimate/medical-research-clean huggingface dataset:
hospital foodservice, patient satisfaction, and malnutrition risk

Conditions: Food Services; Malnutrition

Summary: malnutrition is the body's inability to absorb necessary nutrients, often due to disease, hunger, aging, or other factors. the european society for clinical nutrition and metabolism (espen) focuses on the malnutrition aspect \[1,2\]. unidentified or unmonitored malnutrition before hospitalization, complications affecting eating, patient inability to eat regularly due to exams/treatments, delayed meal times, psychological factors, hospital stay duration, lack of nutrition awareness, prejudices against hospital meals, etc., can lead to hospital malnutrition. patient-related issues and lack of dietitian referrals may contribute, with food service problems being a key factor in nutritional decline \[3,4\]. the critical factors affecting the patient's food appreciation include the appearance, presentation, taste, consistency, texture, and temperature. in cases where patient expectations and satisfaction are not met, a decrease in food consumption and an increase in the amount of leftovers are observed. it has been observed that if the organoleptic properties and presentation style of the food offered to the patient are good, the patients evaluate the food as high quality, and their satisfaction with the food increases \[5\]. as a result, not being able to consume food due to lack of meal satisfaction means that the energy and elements that the patient needs are not taken into the body, which increases the patient's risk of malnutrition \[4\]. effective hospital meal provision is crucial in preventing malnutrition, as emphasized by espen. one of the most essential duties of the dietitian is to supervise every stage of food services to ensure the consumption of foods suitable for medical nutrition treatment of the hospitalized patient \[6,7\]. this study aimed to determine the role and effect of hospital food services on inpatient malnutrition. for this purpose, nrs-2002 screening was performed on 310 inpatients within three days after admission. nrs-2002 is a comprehensive screening test that the espen recommends for hospitalized patients. along with the second nrs-2002 screening, a food service satisfaction survey was administered to patients. the results of both nrs-2002 screening and satisfaction surveys were evaluated.


Eligibility criteria:
inclusion criteria: * aged 18-65 years * volunteers patients * patients who were hospitalized for at least seven days exclusion criteria: * patients with a hospital stay of less than seven days, * receiving oral intake restrictive treatment, * patients in the terminal phase, * patients under 18 years of ages, * patients over 65 years of ages.

Keywords: nutritional assessment food services malnutrition patient satisfaction
rosa knee system vs conventional total knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: this is a randomized clinical study, in which 150 patients with end-stage osteoarthritis will be enrolled to rosa®-assisted knee arthroplasty or conventional knee arthroplasty. patients are recruited at zuyderland medical center, enrolled pre-operatively and followed up for 12 months post-surgery. in- and exclusion criteria are stated below. after recruitment, participants will be invited for a pre-operative visit. during this pre-operative visit informed consent is signed and completion of patient-reported outcome measures (proms) is checked. additionally, measurements regarding body composition, strength and fitness and metabolic outcomes are performed. participants will have a blood sample taken. scans, adverse event and medication use will be confirmed. participants will receive a actigraph for collecting data from physical activity. of all patients, 72 will undergo additional measurements (gait, proprioception). during surgery rosa- and surgery-data will be collected. post-operative participants will have a 6-weeks, 3-month and 12-month visit. during these visits pre-operative measurements are repeated.


Eligibility criteria:
inclusion criteria: * eligible for primary tka * age 40-90 years * body-mass-index 18.5-50.0 kg/m2 * american society of anaesthesiologists class i-iii * willingness and capability to understand and follow protocol exclusion criteria: - rheuma-/trauma-indicated knee arthroplasty

Keywords: robotic-assisted arthroplasty knee arthroplasty gait metabolic syndrome rosa knee system physical activity cost-effectiveness
transcranial magnetic stimulation in alcohol use disorder

Conditions: Alcohol Dependence

Summary: repetitive transcranial magnetic stimulation (rtms) of the dorsolateral prefrontal cortex may affect neuro-adaptations associated with alcohol use disorder (aud), potentially influencing craving and alcohol intake. investigators investigated alcohol intake and dopamine transporter (dat) availability by single photon emission computed tomography (spect) in the striatum of aud patients before and after deep rtms.

the study included aud patients. patients were enrolled by the alcohol addiction unit of the internal medicine, gastroenterology and hepatology department of the catholic university in rome, italy, according to the inclusion criteria. screening collection of medical history, physical, neurological and psychiatric examinations as well as laboratory tests were performed. moreover, patients were underwent to baseline spect assessment of striatal dat availability using 123i-n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123i-fp-cit) as the radiotracer. subsequently, patients were randomized in two groups (matched for gender and age) by a computer program for the real deep rtms or sham. after weekly sessions of deep rtms for four weeks, patients were underwent to the same clinical assessment as in the screening phase and second spect . moreover, the alcohol intake during both the four weeks prior to the enrollment and the 4 weeks of rtms sessions were assessed through the timeline followback (tlfb) interview, an instrument providing a retrospective estimation of the number of drinks per drinking days, the number of drinking days, the number of abstinence days, the number of heavy drinking days and the total number of drinks. patients were also evaluated with alcohol dependence scale (ads), obsessive compulsive drinking scale (ocds), state-trait anxiety inventory scale (stai y1 and stai y2),zung self-rating depression scale.

Eligibility criteria:
inclusion criteria: * at least two days a week of excessive alcohol consumption during the month prior to screening; * ability to provide informed consent; * a clinical institute of withdrawal assessment in alcohol withdrawal score \< 10; * willingness to abstain from or substantially reduce alcohol consumption; * permanent residence. exclusion criteria: * clinically significant psychiatric diseases; * past or current abuse or dependence on substances other than alcohol or nicotine; * neurological disorders; * unstable medical conditions; * pacemakers, implanted metallic pumps, metal implant; * history of complicated withdrawal symptoms; * current use of psychoactive drugs; * epilepsy; * current use of anticonvulsants, insulin or oral hypoglycemic agents; * positive urine toxicological screening; * pregnancy; * participation in other clinical trial in the last 60 days; * involvement in a compulsory medical treatment or pending criminal proceedings.
circadian sleep-wake cycles and light therapy in borderline personality disorder

Conditions: Borderline Personality Disorder; Sleep Disturbances; Depression

Summary: individuals with borderline personality disorder (bpd) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. the investigators examined circadian rhythms, sleep and well-being in women with bpd under their habitual life conditions with and without light treatment. treated women diagnosed with bpd were investigated during 3 weeks without and 3 weeks with morning lt. rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. saliva samples were collected weekly to determine the diurnal melatonin rhythm. a range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. ten matched healthy women followed the same 6-week protocol without light treatment.


Eligibility criteria:
inclusion criteria: * borderline personality disorder (dsm iv-criteria) * german-speaking * normal ocular function exclusion criteria: * lack of compliance

Keywords: circadian rhythms sleep-wake cycles melatonin borderline personality disorder light therapy
vitiligo and the koebner phenomenon (model of vitiligo induction and therapy: a clinical and immunological analysis)

Conditions: Vitiligo

Summary: we will investigate the process of vitiligo induction and the influence of different commonly used cream treatments on this process. studies comparing different treatments for vitiligo in the induction stage of the disease are still missing. the study hypothesis = cream treatment can stop actively spreading vitiligo lesions during the early induction stage of the disease.


Eligibility criteria:
inclusion criteria: * male and female, * age 18-70 years, * extensive vitiligo (\> 50% body surface area), * patients asking for depigmenting therapy, * not pregnant. exclusion criteria: * children, * non extensive vitiligo (\< 50% boy surface area), * patients not asking for depigmenting therapies, * pregnant.

Keywords: vitiligo
a cohort study of plasma cell disorders (pcds) in pkufh

Conditions: Multiple Myeloma; Amyloidosis; Cryoglobulinemia; Castleman's Disease; Light Chain Deposition Disease; Heavy Chain Deposition Disease; Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes; Smoldering Multiple Myeloma; Plasma Cell Leukemia; Monoclonal Gammopathy of Undetermined Significance (MGUS); Monoclonal Gammopathy of Renal Significance (MGRS); Monoclonal Gammopathy of Neurological Significance (MGNS)

Summary: the primary aim is to establish a prospective cohort of patients with plasma cell disorders (pcds). all of the hospitalized pcd patients who are willing to sign the informed consent form (icf) will be included in this study. clinical characteristics, treatment options and responses will be collected. peripheral blood, bone marrow aspirate and urine samples before and after the treatment will banked for future research. our team will focus on the clinical and pathological features of pcds, the correlation between the minimal residual disease (mrd) status and prognosis, and the role of tumor microenvironment (tme) in the pathogenesis and progress of pcds.

primary 1. to establish a prospective cohort of patients with pcds in pkufh. 2. to dynamically analyze the relation between mrd status and prognosis, and the possible role of tme in pcd patients. secondary to collect peripheral blood, bone marrow aspirate and urine samples from pcd patients for future study, such as the tumor clone selection and evolution. outline: pcd patients enrolled in this study will be assessed at baseline, clinical and laboratory data and biological samples be collected. follow-up will be done at the 1, 3, 6, 12 months and then yearly after treatment.

Eligibility criteria:
inclusion criteria: 1. patients included are those with confirmed diagnosis of pcds and hospitalized into peking university first hospital (pkufh) 2. patients of plasma cell disorders (pcds) are recruited. pcds include monoclonal gammopathy of uncertain significance; smoldering myeloma; multiple myeloma; plasma cell leukemia; amyloidosis; light chain deposition disease; heavy chain deposition disease; castleman's disease (cd); polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome; cryoglobulinemia; monoclonal gammopathy of renal significance (mgrs); monoclonal gammopathy of neurological significance (mgns). 3. patients are included into this cohort after signing the icfs. exclusion criteria: significant comorbidity may be life-threatening.
special investigation of pregabalin for fibromyalgia (regulatory post marketing commitment plan)

Conditions: Pain Associated With Fibromyalgia

Summary: to collect the efficacy and safety information of pregabalin on fibromyalgia patients related to their appropriate use in daily practice.

all the patients whom an investigator prescribes the first pregabalin should be registered consecutively until the number of subjects reaches target number in order to extract patients enrolled into the investigation at random.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of fibromyalgia * pregabalin naive patient exclusion criteria: * clinical diagnosis of neuropathic pain

Keywords: lyrica pregabalin good post marketing practice post marketing surveillance regulatory post marketing commitment plan fibromyalgia
palliative chemotherapy in treating patients with advanced colorectal cancer

Conditions: Colorectal Cancer

Summary: rationale: palliative chemotherapy may help patients with advanced colorectal cancer live longer and more comfortably. purpose: randomized phase iii trial to compare the effectiveness of and quality of life following three different palliative chemotherapy regimens in treating patients with advanced metastatic or recurrent colorectal cancer.

objectives: i. compare the survival and quality of life of patients with metastatic or recurrent colorectal cancer receiving palliative therapy with leucovorin/fluorouracil vs. continuous-infusion fluorouracil vs. ici d1694. ii. compare the survival and quality of life of patients with stable or responding disease after 12 weeks of initial treatment randomized to receive 12 additional weeks of chemotherapy vs. no further treatment. outline: this is a randomized study. patients are stratified by participating institution. patients are randomized to one of three treatment regimens. the first group receives leucovorin followed by fluorouracil every 14 days for a total of 6 courses. the second group receives continuous-infusion fluorouracil for 12 weeks. the third group receive ici d1694 every 21 days for a total of 4 courses. patients without progressive disease or excessive toxicity after 12 weeks of treatment are then randomized to receive continuing chemotherapy in 12 weekly cycles of their assigned chemotherapy or to proceed to observation with no further therapy, until evidence of disease progression. patients are followed every 6 weeks. projected accrual: a total of 900 patients will be entered.

Eligibility criteria:
disease characteristics: histologically confirmed adenocarcinoma of the colon or rectum in one of the following categories: locally advanced, metastatic, or recurrent disease suitable only for palliative chemotherapy evaluable disease outside prior radiotherapy field patients with disease confined to the liver are referred to protocol mrc-cr05 patient characteristics: age: not specified performance status: who 0-2 life expectancy: greater than 3 months hematopoietic: wbc at least 4,000 anc at least 2,000 platelets at least 100,000 hepatic: not specified renal: creatinine no greater than 1.25 times normal or creatinine clearance greater than 65 ml/min cardiovascular: no uncontrolled heart failure no uncontrolled angina other: no uncontrolled medical illness (including infection) able and willing to complete quality-of-life questionnaires no prior or concurrent malignancy likely to interfere with protocol treatment or evaluation prior concurrent therapy: no prior systemic chemotherapy except fluorouracil-based adjuvant regimen (e.g., quasar) at least 6 months since chemotherapy

Keywords: stage iii colon cancer stage iv colon cancer stage iii rectal cancer stage iv rectal cancer recurrent colon cancer recurrent rectal cancer adenocarcinoma of the colon adenocarcinoma of the rectum
patient outcomes after hepatic artery infusion pump placement

Conditions: Colorectal Liver Metastases; Colorectal Cancer

Summary: the purpose of this study is to evaluate the surgical outcomes and the quality of life (qol) in patients undergoing hepatic artery infusion pump placement for colorectal liver metastases (crlm).


Eligibility criteria:
inclusion criteria: * patients who receive a hepatic artery infusion pump at mayo clinic rochester for liver metastases from colorectal cancer. * written consent. exclusion criteria: * absence of written consent. * systemic disease. * pregnancy.

Keywords: hepatic artery infusion pump hepatic artery infusion chemotherapy unresectable colorectal liver metastases
efficacy of a probiotic product in children with antibiotic-associated gastrointestinal disorders

Conditions: Antibiotic-associated Diarrhea

Summary: to assess the effect of a probiotic product, when co-administered with antibiotics, on gastrointestinal symptoms following antibiotic treatment in children.


Eligibility criteria:
inclusion criteria: * children at the age of 1-11 years that have been prescribed antibiotic treatment. * problems with loose stools during earlier antibiotic treatments. * children whose parents or legal caregivers have signed the informed consent to participate in the study. exclusion criteria: * chronic intestinal disease, immunodeficiency or immunosuppressive treatment. * chronic or acute diarrheal disease. * use of laxatives the week before inclusion in the study. * antibiotic treatment for the last four weeks before inclusion in the study. * intake of probiotic products for the last two weeks before inclusion in the study. * known hypersensitivity to any of the ingredients in the probiotic product or the placebo (potato starch ± bacterial culture that may contain traces of soy). * patient requiring hospitalisation.
comparisons between dexmedetomidine and magnesium sulfate in controlled hypotension during rhinoplasty surgeries

Conditions: Hypotension

Summary: general anesthesia organizes the best option for controlled blood pressure during rhinoplasty surgery. the primary agent applied in controlling hypotension should have particular unique characteristics. the dexmedetomidine central and peripheral sympatholytic performance is usually indicated by low blood pressure and low heart rate. magnesium sulfate is among the best agents used.

this is a prospective comparative randomized study. 56 patients got enrolled and then divided into two groups. group 1 received dexmedetomidine (n=28), while the group 2 received magnesium sulfate (n=28). map, as well as heart rate, were recorded. surgeon satisfaction was approximated for the surgical field quality. the amount of blood loss during the entire process was measured. the score of pain was evaluated using the nrs rating scale. sedation score through ramsey sedation score. the time required for the first requirement of analgesia was also recorded as well as intraoperative and postoperative problems.

Eligibility criteria:
inclusion criteria: 1. 18-60 years old 2. asa (american society of anesthesiologists) grading i and ii 3. patients undergo rhinoplasty surgery under general anesthesia exclusion criteria: 1. the pregnant ladies 2. patients suffering from hypertension ischemic heart diseases renal insufficiency, neuromuscular diseases, hepatic impairment 3. cerebrovascular inadequacy and diabetic neuropathy, coagulopathies, 4. patients taking antiplatelets 5. refused study, 6. patients of age \ 60 were unauthorized from the study.
evaluation of oxygen consumption and energy expenditure during spontaneous breathing trial.

Conditions: Respiratory Failure

Summary: the purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

patients is going to submit to the 2 spontaneous breathing trial ( automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. the oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Eligibility criteria:
inclusion criteria: * improvement or resolution of the underlying cause of disease * intubated patients\>24h * pao2 greater than 60 mmhg with fio2 less than 40% * peep=5 cmh2o exclusion criteria: * cardiovascular instability * febrile or hypothermia * chest drainage * respiratory rate/tidal volume ratio greater than 105 * pregnancy * fail in the spontaneous breathing trial * leaks in the circuit * agitation * not accept participate in the study

Keywords: indirect calorimetry mechanical ventilation weaning ventilator automatic tube compensation
real-world data on first-line treatment of hormone receptor-positive, her2-negative, metastatic breast cancer in brazil

Conditions: Breast Cancer

Summary: this study aims to describe in detail the patient journey from diagnosis to the beginning of treatment and patterns of care of hormone receptor- positive, her2-negative de novo or recurrent metastatic breast cancer between january 2018 and december 2020 in brazil.


Eligibility criteria:
inclusion criteria: * women ≥18 years old * histologically confirmed hormone receptor-positive her2-negative invasive breast cancer * hormone receptor-positive defined as 1% to 100% of tumor nuclei positive for estrogen - - receptor and/or progesterone receptor, as per asco/cap guideline 2020 - or allred score of ≥3 * her2-negative defined as ihc result is 0/1+ or 2+ with ish negative as per asco/cap guideline 2018 * diagnosed with de novo or recurrent metastatic breast cancer between january 2018 -and december 2020 * public health system or private health system exclusion criteria: * male breast cancer * first-line treatment for mbc received through clinical trial
four arm safety & efficacy with antipyrine and benzocaine otic solution in children with acute otitis media

Conditions: Acute Otitis Media

Summary: the primary objective is to compare the effect of treatment with a combination of ear solutions on the reduction of pain symptoms at 1 hour after dosing in children with acute otitis media.

reduction of pain symptoms will be measured by using the face, legs, activity, cry, consolability scale (flacc) and the faces pain scale revised (fps-r).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute otitis media * moderate to severe pain * normally active and in good health as determined by the pi * parent or legal guardian consent * caregiver available to complete diaries during study exclusion criteria: * history of or current perforated tympanic membrane * tympanostomy tubes * acute or chronic otitis externa * seborrheic dermatitis * received any otic topical or systemic antibiotic within 14 days of enrollment * receiving medication on a chronic basis for pain * known hypersensitivity to investigational product. * clinical significant mental illness as determined by the pi * exposed to another investigational agent within 30 days before study entry. any condition the pi believed will interfere with the ability to comply with all study procedures * history of glucose 6-phosphate dehydrogenase deficiency * history or currently anemic * congenital methemoglobinemia * recent history of acute gastroenteritis within 14 days of enrollment