Kornimate/medical-research-clean huggingface dataset:
cognitive decline following deep brain stimulation

Conditions: Parkinson Disease; Movement Disorders

Summary: this research study aims to identify mri-based brain biomarkers that predict an individual's response to deep brain stimulation (dbs). in particular, this study will focus on changes in cognition associated with dbs. a total of 55 participants with parkinson's disease planning to undergo dbs will be recruited from muscs clinical dbs program. participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-dbs mri scanning visit, and a 3.5-hour post-dbs cognitive assessment visit. in addition control participants without parkinson's disease will be recruited to undergo mri scanning and cognitive assessments.

deep brain stimulation (dbs) targeting the subthalamic nucleus (stn) is a well-established surgical intervention to treat parkinson's disease (pd) patients with disabling motor fluctuations and dyskinesias. although this therapy is effective for motor complications, a subset of patients will go on to experience cognitive decline, which can overshadow improvements in the quality of life provided by stn-dbs. this accelerated decline in cognition occurs in patients despite rigorous evaluation of their neuropsychological status prior to surgery. while the factors contributing to cognitive decline following dbs remain unclear, there is evidence this may be the result of 1) limited cognitive reserve prior to dbs surgery, 2) stimulation that interferes with cognitive networks, and/or 3) a microlesion effect due to placement of the lead. understanding how these factors contribute to dbs-induced cognitive decline has the potential to improve patient selection for surgery and optimize the selection of stimulation targets that minimize undesirable cognitive side effects.

Eligibility criteria:
pd participants inclusion criteria: * subjects above 18 years of age * subjects who will undergo dbs surgery as part of their clinical care for pd exclusion criteria: * uncorrected visual or hearing impairments, as indicated by self-report * individuals who are pregnant or expect to become pregnant during the course of the study * individuals with claustrophobia, or the inability to lie supine position in the mri scanner * copd with oxygen dependence * non-mri compatible metal implants (surgical clips or staples, cardiac pacemakers etc.) non-pd control participants inclusion criteria: * subjects above 18 years of age * age matched to participants in pd group exclusion criteria: * diagnosis of parkinsons disease or other movement disorder * untreated neuropsychiatric disorders * uncorrected visual or hearing impairments, as indicated by self-report * individuals who are pregnant or expect to become pregnant during the course of the study * individuals with claustrophobia, or the inability to lie supine position in the mri scanner * copd with oxygen dependence * non-mri compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
study of long-term outcomes of patients with acute lymphoblastic leukemia who were enrolled as children on clinical trials eortc-58741, eortc-58831, eortc-58832, or eortc-58881 between 1971 and 1998

Conditions: Cancer Survivor; Leukemia; Long-term Effects Secondary to Cancer Therapy in Children

Summary: rationale: studying medical records and collecting questionnaires from patients who were enrolled as children in clinical trials for acute lymphoblastic leukemia may help doctors learn about long-term effects of treatment and plan the best treatment. purpose: this clinical trial is studying the long-term outcomes of patients with acute lymphoblastic leukemia who were enrolled as children on clinical trials eortc-58741, eortc-58831, eortc-58832, or eortc-58881 between 1971 and 1998.

objectives: * to assess the long-term outcomes (i.e., long-term survival, long-term disease status, occurrence of late adverse effects, occurrence of second cancers, and socioeconomic status of survivors) of patients with acute lymphoblastic leukemia previously enrolled as children on clinical trials eortc-58741, eortc-58831, eortc-58832, or eortc-58881 between the years of 1971 and 1998. outline: long-term outcome data are collected from the databases about clinical trials eortc-58741, eortc-58831, eortc-58832, or eortc-58881. other data collected include the patient's vital status actualization (e.g., alive, dead or lost to follow up, date last known to be alive or date of death), medical records data, and the collection of data from patients confirmed to be alive (e.g., data related to marital status, education, work, insurance, puberty, fertility, and offspring) by questionnaire.

Eligibility criteria:
disease characteristics: * patients with acute lymphoblastic leukemia (all) previously enrolled as children (less than18 years of age at diagnosis) on any of the following clinical trials between 1971 and 1998: * eortc-58741 * eortc-58831 * eortc-58832 * eortc-58881 patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: long-term effects secondary to cancer therapy in children cancer survivor recurrent childhood acute lymphoblastic leukemia untreated childhood acute lymphoblastic leukemia t-cell childhood acute lymphoblastic leukemia non-t, non-b childhood acute lymphoblastic leukemia non-t, non-b, calla positive childhood acute lymphoblastic leukemia non-t, non-b, calla negative childhood acute lymphoblastic leukemia non-t, non-b, calla positive, pre-b childhood acute lymphoblastic leukemia childhood acute lymphoblastic leukemia in remission
community-based trial of screening for chlamydia trachomatis to prevent pelvic inflammatory disease

Conditions: Pelvic Inflammatory Disease; Chlamydia Infections

Summary: chlamydial infection is a common, sexually transmitted disease which women can have without knowing. untreated, it can lead to an infection of the womb and fallopian tubes called pelvic inflammatory disease (pid), which can cause infertility. there has been only one trial of chlamydia screening and this was in american women in 1992 and used outdated tests. we now need to see if screening using modern tests and self-taken swabs works in a high risk, young, multiethnic female population in the united kingdom (uk). the study is a randomised trial. it will involve asking women students in college bars to complete confidential questionnaires on sexual health and to provide self-administered vaginal swabs. we have successfully done this in a small pilot study. participants will be told that the tests are for research purposes only and that if they think they may have been at risk of a sexually transmitted infection they should get checked at a clinic. if the trial shows that chlamydia screening using these new methods prevents pid, extending this community-based intervention nationwide could improve women's reproductive health and wellbeing and might prevent some women from becoming infertile

background: pelvic inflammatory disease (pid) is common and can lead to infertility, ectopic pregnancy or chronic pelvic pain. objectives: to see if screening and treatment of chlamydial infection reduces the incidence of pid over 12 months, and to investigate the natural history of chlamydial infection and the role of bacterial vaginosis (bv) in the development of chlamydia associated pid. design: randomised trial over one year setting: common rooms, bars and lecture theatres at universities and colleges in london, uk. participants: 2500 sexually active female students aged \<28 years will be asked to complete a questionnaire on sexual health and to provide a self-administered vaginal swab and smear with follow up after a year. intervention: following randomisation, vaginal swabs from intervention women will be tested for chlamydia by pcr and those infected referred for treatment. vaginal swabs from control women will be stored and analysed after a year. vaginal smears will be gram stained and analysed for bv. main outcome measure: incidence of clinical pid over 12 months in intervention and control groups. possible cases of pid will be identified from questionnaires and record searches. confirmation of the diagnosis will be done by detailed review of medical records by two independent researchers blind to whether the woman is in the intervention or control group.

Eligibility criteria:
inclusion criteria: * sexually active exclusion criteria: * never been sexually active * tested for chlamydia in past 3 months and no new sexual partner since then * pregnant

Keywords: pelvic inflammatory disease chlamydia trachomatis screening
marijuana treatment project - 3

Conditions: Marijuana Dependence

Summary: the goal of this research is to improve treatment outcome for marijuana-dependent individuals. the current study builds on the findings of our prior nida-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. we will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. it is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.

participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (met+cbt). a contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an interactive voice recording (ivr) system. outcomes will be compared to an met+cbt intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives case management. recruitment of 234 marijuana-dependent participants will occur over a three-year period. they will be randomly assigned to one of the three 9-session interventions. treatment will be individual, manualized, and provided on an outpatient basis. pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. it is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. the mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.

Eligibility criteria:
inclusion criteria: * cannabis dependence * willing to accept random assignment to interventions exclusion criteria: * current dependence on alcohol or other drugs * problems that require inpatient hospitalization * reading ability below fifth grade level * lack of reliable transportation to treatment * excessive commuting distance

Keywords: marijuana dependence self-efficacy coping skills attendance marijuana abstinence
dose finding confirmation of atazanavir with ritonavir and efavirenz (atv/rtv + efv) in healthy subjects

Conditions: HIV Infections; Protease Inhibitor

Summary: the purpose of this study is to assess the exposure of atazanavir 400 mg with ritonavir 100 mg and with efavirenz 600 mg compared to atazanavir 300 mg with 100 mg without efavirenz in healthy subjects


Eligibility criteria:
inclusion criteria: * bmi 18-30 * men and women who are not of childbearing potential, ages 18-50 years, inclusive exclusion criteria: * history of seizures or other central nervous system disorders (including migraine headaches) * history of diagnosed mental illness or suicidal tendencies * positive screening for hep b surface antigen * hep c antibody * hiv-1, -2
comparing two different rehabilitation protochols on patients with rotator cuff repair

Conditions: Rotator Cuff Tear

Summary: rotator cuff (rc) repair is one of the most common treatment approch to relief the pain and improve the shoulder function on patients with rotator cuff rupture. despite the improved surgical techniques and decreased failure rate, there are still complications after the surgey like shoulder persistant shoulder pain, stiffness even re-tear. therefore, rehabilitation after the rc repair procedure is crucial for the success of the treatment. however, there is no concencus between the post-operative rehabilitation protochol. the aim of this study is to compare two different rehabilitation protochols on patients with rc repair.

rotator cuff (rc) repair is one of the most common treatment approch to relief the pain and improve the shoulder function on patients with rotator cuff rupture. despite the improved surgical techniques and decreased failure rate, there are still complications after the surgey like shoulder persistant shoulder pain, stiffness even re-tear. therefore, rehabilitation after the rc repair procedure is crucial for the success of the treatment. however, there is no concencus between the post-operative rehabilitation protochol. the aim of this study is to compare two different rehabilitation protochols in terms of shoulder range of motion, self-reported shoulder function and pain on patients with rc repair.

Eligibility criteria:
inclusion criteria: * having a rotator cuff repair surgery * having post-op rehabilitation program at our clinic until post-op 3 months * no previous surgery in the shoulder joint exclusion criteria: * additional pathology other then rc tear * refusing to participate to the study

Keywords: shoulder rotator cuff exercise
entropy and surgical pleth index guided closed loop target controlled infusion total intravenous anesthesia with propofol

Conditions: Anesthesia Awareness

Summary: closed-loop infusion system for target controlled infusion of propofol by using tci pump designed by bd technology. (germany) guided with entropy and surgical pleth index (ge) will not only prevent awareness from anesthesia but also optimise the dose anesthetic agents based on feedback from adequacy of anesthesia monitoring. which not only reduces anesthesia agents but also enhances recovery from anesthesia. innovation using tci combined with closed-loop controlled intravenous anesthesia under the guide of entropy.in this study we performed a randomized, controlled, study to compare closed-loop control and open-loop control of propofol by using the entropy and spi guided closed-loop infusion system.

monitoring of adequacy of anesthesia using entropy and surgical pleth index to guide total intravenous anesthesia is more effective to maintain depth of anesthesia compared with target controlled infusion with open systems, it is unclear what driver and variables to achieve this goal be more physiological; in the literature doesn´t exist studies showing that the closed-loop system for hypnotic is better than the controlled algorithm based pharmacokinetic models and open loop system (target controlled infusion-tci) to maintain anesthetic depth. thus, a system was designed for intravenous anesthesia in closed loop for propofol as hypnotic based on neuromonitoring with entropy and surgical pleth index as adequacy of anesthesia depth. the purpose of this study is to determine the therapeutic effectiveness of a closed loop tci for administration of intravenous anesthesia using adequacy of anesthesia monitoring to maintain a depth of anesthesia compared to an open loop system tci.

Eligibility criteria:
inclusion criteria: * older than 18 years * scheduled for noncardiac surgery elective low-risk or intermediate risk. -expected surgery time greater than 1 hour * procedure requiring general anesthesia * classification of the american society of anesthesiologists (asa) as i,ii, lll exclusion criteria: * pregnant women * surgery scheduled urgent or emergency * personal history of allergy to eggs or any other part of propofol * personal history of abnormalities or congenital or acquired cognitive sequels: infantile cerebral palsy, down syndrome, cerebral ischemic disease, traumatic brain injury, brain tumor, autism. * chronic use of benzodiazepines or antipsychotics * a patient who does not consent to participate in the study prior to surgery or before randomization * need for anesthetic or analgesic blockade before surgery peripheral nerve

Keywords: closed loop entropy surgical pleth index adequacy of anesthesia target controlled infusion
hipec after radical cystectomy for high risk bladder cancer

Conditions: Invasive Bladder Cancer

Summary: this is a non-randomized, non-blinded, pilot study administering hyperthermic intraperitoneal chemotherapy with mitomycin-c in 10 men and women with muscle-invasive urothelial carcinoma of the bladder undergoing radical cystectomy with pelvic lymph node dissection who have risk factors for tumor recurrence.


Eligibility criteria:
inclusion criteria: 1. primary urothelial cell carcinoma of the bladder 2. patient's aged 45-85, both genders. 3. ecog performance status \< 1 4. hematology: anc \> 1.5x109/l; platelets \> 100x109/l 5. women with child bearing potential who are negative for pregnancy test (urine or blood) and who agree to use effective contraceptive method. reliable contraception should be used from trial screening and must be continued throughout the study. a woman of childbearing potential is defined as one who is biologically capable of becoming pregnant. 6. signed and dated written informed consent to participate in this clinical trial must be obtained prior to any study procedure. either any of the following preoperative factors for increased risk of recurrence: 7. lymphovascular invasion 8. variant histology in the background of primary urothelial (notably plasmacytoid) 9. clinical t3 or greater 10. clinical n+ 11. no prior neoadjuvant chemotherapy (nac) or lack of response to nac or any of the following perioperative factors for increased risk of recurrence: 12. palpable concern for extravesical disease 13. tumor spillage/bladder entry 14. suspicious nodes or positive intraoperative frozen sections exclusion criteria: 1. subjects who have previously undergone intraperitoneal chemotherapy. 2. subjects with tumor histology other than urothelial cell carcinoma. 3. patients on concurrent anti-cancer therapy other than that allowed in the study. 4. other prior malignancies, except for cured non-melanoma skin cancer or curatively treated in situ carcinoma of the cervix or adequately treated malignancies for which there has been no evidence of activity for more than 3 years. 5. subjects with renal insufficiency defined as creatinine \> 1.5x the upper limit of normal or a calculated creatinine clearance of \< 50 cc/min. 6. subjects with a condition which may interfere with the subjects' ability to understand the requirements of the study. 7. known hiv, hepatitis b or hepatitis c positive. 8. subjects with uncontrolled concurrent illness including, but not limited to, ongoing or severe infection requiring antibiotics, symptomatic congestive heart failure, unstable angina pectoris, acute gastrointestinal bleeding, psychiatric illness or other condition which in the opinion of the investigator, places the patient at an unacceptable risk for participation in the study. 9. any condition that would preclude the ability to deliver appropriate ip therapy.

Keywords: high-risk bladder cancer urothelial cancer hipec mitomycin
early predictors of prognostic course in patients with covid-19 in critical or semi-intensive area.

Conditions: Covid19; C-reactive Protein; Procalcitonin; D-dimer

Summary: although the recent literature is building a remarkable background to answer the many unknowns related to sars-cov-2 infection, it is absolutely necessary to finalize every clinical effort to collect data that may be useful, in a short time, to improve our knowledge of sars-cov-2 infection. numerous biomarkers have been evaluated in the recent literature as being altered in patients with severe forms of covid-19. particularly, in the critical care area, the research of early predictors of mortality is essential for high-flow management of patients requiring invasive assisted ventilation and requiring invasive and non-invasive assisted ventilation, hemodynamic support, sometimes extracorporeal support (extracorporeal membrane oxygenation, ecmo). the coordinated study of different biomarkers, in particular, if combined with each other, possibly even to constitute a possible score, could guide the correct allocation of patients between hospital departments and the appropriate management in intensive care units. appropriate management in intensive care units, as well as providing an early prognostic indication. prognostic indication. the combination of these biomarkers with routine clinical and laboratory data may further provide valuable information about their use in acute care and as progressive acute and as progressive monitoring over time. regarding the data of interest on the clinical trend, the evaluation of the respiratory support modalities, from the administration of oxygen therapy (by nasal cannulae or venturi mask, or by high flow system - high flow nasal cannula, hfnc), to cpap support or by non-invasive or invasive ventilation, appears of particular importance. therefore, the present study will be conducted in sub-intensive as well as intensive care units, in order to evaluate different types of patients, and their possible evolution over time. the comparison between the populations belonging to different areas of intensity of care will be able to describe the different populations. data analysis will allow an evaluation of possible risk factors and prognostic determinants of the severity of the disease and its infectious complications.


Eligibility criteria:
inclusion criteria: * hospitalized patients with clinical signs and symptoms of covid-19, confirmed by nasopharyngeal swab rt-pcr of airways positive for sars-cov-2 * age \> 18 years * hospitalization in the departments of the hospitals involved exclusion criteria: * none
light-induced effects on dental implant stability

Conditions: Missing Teeth

Summary: until now, limited research has observed the stability of photo functionalized sandblasted acid-etched (sla) titanium implants. the study includes a sample size of sixty otherwise healthy patients with implant replacement, comparing nonirradiated, irradiated uva and uvc titanium implants. it was an interventional study with a sample size divided into three groups using simple randomization. patients with nonirradiated dental implants make the control group a with uva and uvc dental implants forming groups b and c, respectively. before functional loading, implant stability was measured on days zero and eight weeks. spss 26.0 is used for data analysis. the data for implant stability quotient (isq) levels and osseointegration speed index (osi) were presented as mean ± sd for each group. the effect of uva and uvc on isq2 compared with the baseline isq was done by applying multiple simple regression analysis models, whereas the distinction between uva and uvc was made through a t-test. p ≤ 0.05 was kept statistically significant. the implants irradiated with uva significantly affected isq levels compared to other groups.


Eligibility criteria:
inclusion criteria: * systemically healthy patients with age \> 20 with at least one tooth or more missing exclusion criteria: -

Keywords: dental implants