Kornimate/medical-research-clean huggingface dataset:
a study to assess regional cerebral blood flow as an alzheimer's disease biomarker compared to positron emission tomography in patients with mild-to-moderate alzheimer's disease and cognitively normal elderly subjects (study mk-0000-068)(completed)

Conditions: Alzheimer's Disease

Summary: the aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dasl), can be a biomarker for stage of alzheimer's disease. the study is designed to be conducted in 2 parts in participants with mild to moderate alzheimer's disease, and participants with normal cognition. various imaging studies will be done using magnetic resonance imaging (mri) and positron emission tomography (pet) along with neurocognitive assessments. participants who meet the study-entry criteria will have up to 8 study visits. repeat imaging studies may be required if the initial data are incomplete or un-interpretable. the maximum number of pet scans during the study will be limited to four.


Eligibility criteria:
inclusion criteria: the prospective participant must meet, at least, all of the criteria below (among others determined by the study staff) to be eligible for study participation. the participant: * has mild-to-moderate alzheimer's disease (ad), or is considered cognitively normal; * has been on stable doses of any regularly used medications for 4 weeks prior to study start; * must have been on a stable dose for 12 weeks prior to study start, of any medications taken for ad. exclusion criteria: if the prospective participant meets any of the criteria below (among others determined by the study staff) they will not be eligible for study participation. the participant: * is living in a nursing home or skilled nursing facility; * has severe ad; * cannot undergo mri; * cannot undergo pet scans; * has a history of neurological or neurodegenerative disorders, other than ad within 2 years prior to study start; * has taken tacrine or anti-parkinsonian medications within 3 months of study start; * has taken corticosteroids, blood thinners, narcotic analgesics, benzodiazepines, or certain antihistamines within 1 month of study start; * initiates, discontinues, or changes the dose of any ad treatment during the study.

Keywords: alzheimer's disease, mri, pet
effect of acupressure on postoperative pain with gynecologıcal surgery

Conditions: Acupressure; Post Operative Pain; Nurse's Role

Summary: in this study, the effect of acupressure on postoperative pain level in women with abdominal gynecologıcal surgery will be studied and it will be conducted as a randomized controlled intervention study to examine the relationships with each other.the sample group will consist of 102 women, 51 in the intervention group and 51 in the control group.within the scope of the study, the data will be collected using the 'personal information form and short-form mcgill pain questionnaire (sf-mpq)' created by the researcher. data will be analyzed using spss-26 package.

in this study, the effect of acupressure on postoperative pain level in women with abdominal gynecologıcal surgery will be studied and it will be conducted as a randomized controlled intervention study to examine the relationships with each other.the sample group will consist of 102 women, 51 in the intervention group and 51 in the control group.within the scope of the study, the data will be collected using the 'personal information form and short-form mcgill pain questionnaire(sf-mpq)' created by the researcher. data will be obtained by the researcher by faceto-face interviews with women. in addition, women in the intervention group will receive acupressure once on postoperative days 0 and 1. acupressure points related to gynecological surgery (large intestine (li4), stomach (st36) and spleen (sp6)) will be applied for a total of 12 minutes with 2 minutes of pressure on each point. women in the control group will continue their routine care. data will be evaluated with spss-26 package.

Eligibility criteria:
inclusion criteria: * 20 years of age or older, * being literate, * to be able to understand and speak turkish, * no deformity or lesion in the areas where acupressure will be applied, * undergoing abdominal gynecologic surgery with general anesthesia, * any narcotic or epidural for pain control after surgery lack of analgesia * participation in the routine pain protocol of the clinic exclusion criteria: * the presence of any systemic disease that causes chronic pain, * receiving spinal or epidural anesthesia, * patients who are administered narcotic or any analgesic drug other than the routine pain protocol applied in the clinic after surgery
effects of invasive and noninvasive mechanical ventilation on sleep in the intensive care unit (icu)

Conditions: Respiratory Insufficiency; Respiration, Artificial; Sleep Deprivation

Summary: the purpose of this study is to monitor sleep in patients using breathing machines, because little is known about sleep when patients use masks to help their breathing. we'd like to compare sleep in patients using masks to that in patients with a tube in their throats.

sleep in critically-ill patients is commonly severely fragmented, and sleep architecture is altered as compared to a healthy person. this abnormal sleep may cause some important adverse psychological and physiological consequences. noise, light, patient-care activities, pain, or medications are some of the contributing factors to sleep disruption in the icu. recent evidence also suggests that invasive mechanical ventilation (imv) itself may lead to sleep fragmentation in the icu. noninvasive ventilation (niv) is a well-established, relatively new form of ventilation which improves sleep quality or gas exchange in some patients with chronic hypoventilatory disorders. although sleep may be disrupted due to discomfort from the mask or air leaking during niv use; intermittent use of niv may result in better sleep quality between niv sessions. the effects of niv on sleep in the acute care setting have not yet been studied. the purpose of the study is to describe the sleep architecture of a cohort of critically-ill patients using niv, comparing findings to a reference group of patients using (imv).

Eligibility criteria:
inclusion criteria: * age \> 18 yrs * receiving invasive or noninvasive mechanical ventilation * anticipated further ventilation of at least 24-hour duration for imv and 8 hours/ 24 hours for niv exclusion criteria: * pre-morbid diseases that could interfere with interpretation of sleep monitoring including cns disorders (strokes, encephalopathic states), dementia, and known sleep disorders * on home bipap or cpap * depressed sensorium as evidence by glasgow coma score \< 10, need for continuous sedation with riker score \< 2 and inability to follow verbal commands for sustained 3 hours * presence of head trauma, psychiatric illness (including use of antidepressant medication), anoxic brain injury, drug overdose or uncontrolled seizure disorder * severe hemodynamic instability (bp\< 90 mmhg despite vasopressor therapy) and sepsis * recalcitrant hypoxemia (inability to sustain sao2 \> 88%) * considered as unstable by icu team (hemodynamic instability, acute uncontrolled gi bleeding, acute cardiac ischemia or arrhythmias)

Keywords: respiration, artificial respiratory insufficiency noninvasive ventilation sleep deprivation intensive care units
understanding pain perception in osteoarthritis

Conditions: Osteoarthritis; Pain

Summary: osteoarthritis (oa)is a painful and disabling disease, predicted to be the fourth largest cause of disability worldwide by 2020. it commonly affects the hip or knee ultimately resulting in total joint replacement. in order to assess disease progression and plan surgery, x-rays are taken as part of routine practice. however x-rays provide limited information about formation of substructures and changes occurring during progression of disease. the proposed study aims to invite patients with oa of the hip or knee to participate in detailed examinations of their pain and their painful joint through interviews, blood and urine samples taken, mri magnetic resonance imaging)and donating their waste tissue after joint surgery (all of old joint). informed patient consent will be sought in all cases.

the patient will be asked for permission for a clinician to access their notes for information relevant to the research, including full medical history, their sex and date of birth. tissue obtained from joint replacement surgery at st. george's hospital and transferred to st.george's, university of london where it will be prepared for various experiments including looking at the genes and proteins in people with osteoarthritis. the blood and urine samples will also be taken to st. george's, university of london, and prepared for studies on the genes and proteins in people with osteoarthritis. all samples provided will be anonymised with no patient details on the samples and stored in locked freezers, in locked labs. at st.george's, university of london.

Eligibility criteria:
inclusion criteria: inclusion criteria for oa patients: study participant will be recruited from rheumatology outpatient clinics and primary care: 1. fulfilling the american college of rheumatology (acr) criteria for the diagnosis of knee osteoarthritis 2. male or female, 3. symptomatic knee pain 4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal anti-inflammatory drugs 5. participants between 35 and 90 who will be undergoing knee replacement surgery or arthroscopy for osteoarthritis or knee surgery for fractured tibia/femur/fibula with osteoarthritis inclusion criteria for early oa patients study participant will be recruited from rheumatology outpatient clinics and primary care: 1. fulfilling the american college of rheumatology (acr) criteria for the diagnosis of knee osteoarthritis 2. male or female, 3. symptomatic knee pain 4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal anti-inflammatory drugs 5. participants between 35 and 90 who have osteoarthritis but will not be undergoing knee surgery inclusion criteria for healthy control subjects 1. participants aged between 35 and 90 who do not have knee pain or osteoarthritis as a comparator group

Keywords: pain magnetic resonance imaging
gait rehabilitation following an anterior cruciate ligament reconstruction

Conditions: Complete Tear, Knee, Anterior Cruciate Ligament

Summary: a randomized control trial where subjects following an anterior cruciate ligament reconstruction will be randomized to either a control group who will receive the normal rehabilitation or an experimental group who will perform a 2-week gait rehabilitation using the anti-gravity treadmill in addition to the normal rehabilitation. the intervention will be added to the existing care received at linkoping university hospital 2 weeks post-surgery, while the evaluation will be performed in week 5 and 12 post-surgery using: a 3d-gait analysis (with the qualisys software), self-reported function questionnaires and a clinical examination.


Eligibility criteria:
inclusion criteria: * anterior cruciate ligament injury occurred a minimum of 3 weeks prior to surgery exclusion criteria: * previous anterior cruciate ligament injury * other knee injury with restrictions that could interfere with rehabilitation * other injury or disease that could interfere with rehabilitation * inability to understand the information

Keywords: acl-reconstruction gait rehabilitation anti gravity treadmill acl-rehabilitation
a rct of a fully-automated self-help aebt website

Conditions: AEBT Website With Check-ins; AEBT Website Without Check-ins

Summary: trichotillomania (ttm) is characterized by hair pulling that is repetitive in nature leading to notable hair loss, causing clinically significant distress and resulting in impairments across social and functional domains (apa, 2013). trichotillomania causes significant social impairment including affecting close relationships, pursuing occupational changes or advancement, or interfering with schooling (grant et al., 2017; woods, flessner, franklin, wetterneck, et al., 2006). the core of the treatment of trichotillomania has traditionally been habit reversal training (hrt) (twohig, bluett, et al., 2014). another form of treatment that is gaining empirical support is acceptance and commitment therapy (act) which has been studied in four randomized controlled trials, one studying act as a standalone treatment (lee, homan, et al., 2018), and three examining act combined with hrt (twohig et al., 2021; lee, haeger, et al., 2018; woods, wetterneck, et al., 2006) which demonstrated efficacy of the combined treatment in decreasing pulling symptom severity. the prevalence of trichotillomania in the us is 1-2% of the population and yet treatment access is limited by many issues including processionals' lack of knowledge of the disorder and low treatment accessibility (walther et al., 2010). act- enhanced behavior therapy has been implemented using telehealth to reach a larger population (42.2% decrease pre-to-post treatment), but telehealth still requires therapist time and incurs notable costs (lee, haeger, et al., 2018). the present study aims to address the gap in trichotillomania treatment accessibility by examining the role of check-ins on adherence and efficacy on afully automated, web-based act-enhanced hrt treatment for adults with trichotillomania across the united states. we predict that the condition with check-ins will increase adherence and efficacy of the treatment significantly more than the condition without check-ins. additionally, we predict that hair pulling severity and psychological flexibility will be significantly improved by the condition with check-ins compared to the condition without check-ins.


Eligibility criteria:
inclusion criteria: 1. currently meet dsm-5 criteria for trichotillomania 2. searching for trichotillomania-based treatment 3. are atleast 18 years old 4. fluent english speakers 5. living in the u.s. exclusion criteria: 1. currently receiving alternative therapy 2. currently modifying or starting psychotropic medication 3. previously met dsm-5 criteria for trichotillomania but are not, at the time of intake session, engaging in hair pulling
aging and cellular mechanism for insulin action after exercise training

Conditions: Diabetes Mellitus

Summary: this study will determine whether the metabolic and cellular mechanisms contributing to improved insulin action after aerobic or resistive exercise are different in older, obese, insulin resistant veterans. the hypothesis is that regular exercise, whether aerobic or resistive, will improve whole body insulin action, but the nature and magnitude of changes in skeletal muscle will differ between the two types of exercise.

veterans will be of comparable body composition and age, and randomly assigned to either aerobic or resistive exercise. they will be instructed in a weight maintenance diet prior to beginning the exercise program, and maintain this diet throughout the study. metabolic testing will be performed at baseline and after 6 months of exercise training. testing will include measurement of body composition (anthropometry, dual-energy xray absorptiometry, computed tomograph scan), maximal oxygen consumption, and muscle strength, glucose tolerance (oral glucose tolerance test), insulin sensitivity (euglycemic-hyperinsulinemic clamp), and muscle biopsies to examine skeletal muscle metabolic characteristics (fiber type distribution, capillary density, oxidative and glycolytic enzyme activities, and levels of key proteins important in insulin signaling and glucose transport). data will be analyzed using analysis of variance to determine differences between the two exercise groups, and multiple regression analysis to determine the primary adaptations that are associated with the improvements in whole body insulin action.

Eligibility criteria:
males between 50 years and 80 years overweight non-smoker sedentary (no regular exercise for one year)
clinical outcomes of acl reconstruction augmented by an injectable osteoconductive/osteoinductive compound

Conditions: ACL Injury

Summary: the goal of this study is to determine whether the use of injectable osteoinductive/osteoconductive compounds (ooc) during anterior cruciate ligament (acl) reconstructive surgery, combined with an accelerated rehabilitation protocol (arp) provides clinical outcomes superior to those attained via traditional acl reconstruction and delayed rehabilitation protocols.


Eligibility criteria:
inclusion criteria: * any adult undergoing a surgical procedure for hamstring acl reconstruction exclusion criteria: * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners
french cohorte extra-vascular implantable cardioverter defibrillator

Conditions: Defibrillators, Implantable; Sudden Cardiac Death Due to Cardiac Arrhythmia

Summary: implantable cardioverter-defibrillators (icds) are widely recognized for their efficacy in reducing the risk of sudden cardiac death in high-risk patients. nonetheless, there remains significant scope for improving outcomes through advancements in device technology and design. the extravascular cardioverter-defibrillator (ev-icd) represents such an innovation, offering key advantages over other icd systems. it incorporates a lead positioned in the substernal space, enabling the delivery of pause-prevention security pacing, antitachycardia pacing, and defibrillation energy similar to that provided by conventional transvenous icds. previous studies have demonstrated that ev-icds can be implanted safely and are capable of terminating majority of induced ventricular arrhythmias during implantation; however, follow-up data are limited to highly experienced selected centers and over a relatively small follow-up period (6-month follow-up). the forever cohort study, initiated by the french institute of health and medical research, aims to evaluate the ev-icd use in france. this nationwide evaluation will provide an exhaustive collection of all ev-icd implantations in france, offering valuable real-world evidence on the long-term safety and efficacy of the device.


Eligibility criteria:
inclusion criteria: * all patients undergoing ev-icd implantation exclusion criteria: * refusal of consent

Keywords: implantable cardioverter defibrillator sudden cardiac death extravascular implantable cardioverter-defibrillator
virtual lv lead navigation in patients with ischemic cardiomyopathy

Conditions: Cardiomyopathy; Ischemic Cardiomyopathy

Summary: presently, the left ventricular lead is placed in a similar position for all patients. it is not known whether placing this lead in different positions in the heart will make the heart pump better. in this study, the investigator will collect measurements of the heart's electrical activity during an electrophysiology study (ep study or eps). the hope is that these measurements will provide the know how to develop an individualized left ventricular lead placement "prescription" for patients referred for left ventricular lead pacing.


Eligibility criteria:
inclusion criteria: * ischemic cardiomyopathy * intrinsic qrs duration \>120 milliseconds * lv ejection fraction \<40% exclusion criteria: * persistent atrial tachyarrhythmia * active cardiac ischemia * cerebrovascular accident within 6 months * surgical or percutaneous cardiac revascularization procedure within 3 months * under 18 years of age * pregnant * participating in a clinical study that would preclude enrollment * unable to provide informed consent

Keywords: ischemic cardiomyopathy cardiomyopathy left ventricular lead cardiac electrophysiologic studies
ph 2 study of tas-102 / bevacizumab maintenance therapy post induction chemotherapy in metastatic colorectal cancer

Conditions: Metastatic Colorectal Cancer

Summary: phase ii study of tas-102 plus bevacizumab switch maintenance therapy in patients with mcrc

study drug: tas-102 (trifluridine and tipiracil hydrocholoride) and bevacizumab dosing details: starting dose of tas-102 is 35 mg/m2 administered orally twice daily, after meals, for 5 days a week with 2 days rest for 14 days, followed by 14 days rest (1 treatment cycle). bevacizumab 5 mg/kg intravenously every 14 days. the treatment cycle repeats every 28 days. patients may take tas-102 plus bevacizumab until they exhibit progression of disease, withdraw consent, or experience unacceptable toxicity.this is a single arm study. all patients receive the same study treatment.

Eligibility criteria:
inclusion criteria: * written informed consent * histologically proven, unresectable, evaluable metastatic colorectal cancer * 16 to 20 weeks of first-line therapy with oxaliplatin, and/or irinotecan-based flourorpyrimidine-containing chemotherapy plus bevacizumab * patients must have stable disease (or better) during the initial induction chemotherapy with first-line chemotherapy. * no progressive disease at the time of initiation of maintenance therapy * eastern cooperative oncology group (ecog) performance status of 0 to 1 * adequate organ and marrow function * women of child-bearing potential and men must agree to avoid pregnancy * patient must start maintenance therapy at least 14 days after the last administered induction chemotherapy but no later than 30 days. exclusion criteria * patients whose tumors have progressed on first-line treatment * patients with active concurrent malignancy, other than superficial, non-invasive squamous cell carcinoma of the skin or uterine cervix, within the past three years. * women who are pregnant or lactating * unstable heart disease * uncontrolled active infection requiring antibiotics within one week prior to first dose. * patients with active cns malignancy. * persistent protein in the urine * patients with bowel obstruction or uncontrolled vomiting. * patients with serious psychiatric or medical conditions that could interfere with treatment.

Keywords: metastatic colorectal cancer advanced colorectal cancer
association between natural hypoglycemic foods and blood sugar level: a pilot study

Conditions: Type II Diabetes

Summary: type 2 diabetes patients often do not reach desired control of glycemia despite guidance on changing lifestyle and diet as well as the use of conventional anti-diabetic medication. parallely in recent years, an array of comparative clinical studies have demonstrated the anti-diabetic effect of more than 10 common spices and food products. objectives: to evaluate whether proposing a choice of spices and foods products with hypoglycemic effect to diabetic patients can help better control diabetes.

diabetic type ii patients would be encouraged to eat what they like within a list of food products with hypoglycemic effect, at a similar dosage and preparation mode than the one in the reference clinical trials. this pilot project will be conducted as a randomized controlled trial with 2 arms over 12 weeks: 1. training patients about hypoglycemic spices and foods alongside their usual anti-diabetic treatment, versus usual anti-diabetic treatment alone. expected results: confirmation of the hypothesis that daily consuming spices and foods with hypoglycemic effect to diabetic patients can help better control diabetes.

Eligibility criteria:
inclusion criteria: * type 2 diabetes patients with poorly controlled glycemia, i.e. at least one of the following measurements: 1. fasting plasma glucose (fpg) values ≥ 7.0 mmol/l (126 mg/dl), or 2-h post-load plasma glucose ≥ 11.1 mmol/l (200 mg/dl), or hba1c \> 6.5% (48 mmol/mol); or a random blood glucose ≥ 11.1 mmol/l (200 mg/ dl), despite ≥ 3 months usual care (lifestyle + medication if applicable). exclusion criteria: 1. severe and unstable complications of diabetes: end-organ damage such as nephropathy, retinopathy, neuropathy, etc... 2. patients with rapid insulin, 3. any health condition that requires urgent attention, 4. patients with a cognitive or sensory impairment that may prevent conducting the interview, 5. hba1c \> 11.5% 6. pregnant women