Kornimate/medical-research-clean huggingface dataset:
different doses of vitamin d and t regulatory cells in preterm infants

Conditions: Prematurity; Immune Defect

Summary: this study evaluate the effect of two different doses of vitamin d on t-regulatory cells in preterm infants. half of the subjects receives 400 iu vitamin d and the other half receives 800 iu vitamin d.

vitamin d, in addition to its bone mineralization effect, is an immune- modulatory agent. fetal and premature cellular immunity are generally delayed. whether vitamin d can enhance cellular immunity by increasing t regulatory cells is unknown. the effect of two different doses of vitamin d; 400 iu and 800 iu will be studied.

Eligibility criteria:
inclusion criteria: * preterm infants with gestational age 28-33 weeks exclusion criteria: * necrotizing enterocolitis * bowel perforation * chromosomal anomalies * inborn errors of metabolism * major congenital anomalies
effect of a new oral contraceptive pill on hormone related symptoms such as pelvic pain and headache

Conditions: Oral Contraceptive; Headache; Pelvic Pain

Summary: the aim of the present study is to investigate whether women taking a new combined oral contraceptive pill (sh t00658id, estradiol valerate/dienogest) experience fewer hormone withdrawal-associated symptoms such as pelvic pain or headache during their monthly cycle compared to a commonly used contraceptive pill (microgynon).


Eligibility criteria:
inclusion criteria: * age between 18 and 50 years (inclusive) at visit 1, for smokers up to 35 years (inclusive) * otherwise healthy female subjects requesting contraception and currently using a levonorgestrel, gestodene or desogestrel containing oral contraceptive in a 21-day regimen and suffering from at least moderate pelvic pain, headache or both defined by an average value of \>/= 35 mm for the 3 highest values on a visual analogue scale during cycle days 22-28. * normal or clinically insignificant cervical smear not requiring further follow up (or a normal result obtained within the last 6 months before screening) * able to tolerate ibuprofen and willing to use only ibuprofen supplied for the study. exclusion criteria: * women with any contraindication for oral contraceptive use

Keywords: combined oral contraceptives pelvic pain headache
establishing mobile transcranial magnetic stimulation

Conditions: Treatment Resistant Major Depression

Summary: in this pilot study, investigators propose to design and create a portable tms unit, in a van, and then test out delivering tms in three different locations in south carolina, all affiliated with musc and within 2-hours driving from charleston, sc. this study would test out this new delivery mode, and provide valuable feasibility, safety, and efficacy lessons for later refinement and potential widespread adoption of mobile tms as a treatment option, both in our state and across the us.

in this pilot study, investigators propose to design and create a portable tms unit, in a van, and then test out delivering tms in three different locations in south carolina, all within 90 minutes driving from charleston, sc. this study would test out this new delivery mode, and provide valuable lessons for later refinement and potential widespread adoption of mobile tms as a treatment option. this would open up access to tms for millions of patients with treatment resistant depression who cannot be treated in the current model. after this pilot feasibility and efficacy study, future research would use mobile tms units for siting at residential care facilities, or remote hospitals and clinics. investigators aim to determine whether it is possible to assemble and build a functioning mobile tms unit. after assembling the van, investigators will then recruit up to 30 treatment-resistant depression patients who live near one of three satellite musc clinics. these clinics are all within a 2 hour drive from the musc charleston campus. investigators will treat these patients, open label, with fda approved accelerated tms (6 sessions each day, over 2 hours, for 5 days, spread over one or two weeks). investigators will measure tms effectiveness using standard depression rating scales. importantly, investigators will also collect the costs of performing the tms which will inform whether musc or other health delivery systems might adopt this tms method.

Eligibility criteria:
inclusion criteria: * adult (22-80 years old) * have treatment-resistant depression as defined by the e-mini, and the antidepressant treatment history form (athf short). * be able to read and communicate in english. * able to provide their own consent. * access to a computer with videoconferencing ability for initial consent and telescreen. exclusion criteria: * patients with unstable medical conditions that might make tms unsafe. this includes current poorly controlled seizures. * ferromagnetic metal in the head. * pregnant. * currently active substance abuse except tobacco.

Keywords: anxiety depression
kendall exercises on posture-related cervical spondylosis

Conditions: Cervical Spondylosis

Summary: this study evaluates the effectiveness of kendall exercises in correcting postural deviations, such as forward head posture, associated with cervical spondylosis. by targeting muscle imbalances and improving alignment through stretching and strengthening protocols, the research aims to reduce symptoms, enhance cervical spine function, and promote postural health. participants will undergo a four-week exercise intervention with pre- and post-assessments to determine the outcomes.

this study investigates the impact of kendall exercises on posture-related cervical spondylosis, a degenerative condition often linked to postural deviations like forward head posture (fhp). prolonged poor posture, frequently exacerbated by activities such as excessive smartphone or computer use, leads to muscle imbalances, increased mechanical stress on the cervical spine, and degenerative changes in intervertebral discs and joints. kendall exercises are targeted therapeutic interventions designed to address muscle imbalances by strengthening weak muscles (e.g., deep cervical flexors) and stretching tight muscles (e.g., upper trapezius, pectoralis muscles). these exercises aim to restore proper alignment, reduce mechanical strain, and improve overall posture and cervical function. participants with posture-related cervical spondylosis will engage in a four-week exercise protocol involving specific kendall exercises for cervical extensors, flexors, shoulder retraction, and chest muscles. outcomes will be assessed using craniovertebral angle measurements, photographic analysis, and subjective pain/function scales. the study seeks to establish kendall exercises as a non-invasive, effective intervention for managing cervical spondylosis by correcting postural deviations and mitigating associated symptoms

Eligibility criteria:
inclusion criteria: * • already diagnosed patients of cervical radiculopathy confirmed by clinical examination and imaging * a patient with a forward head posture (fhp) (cva angle less the 48-50 degrees is defined as forward head posture * positive spurling test * numbness of the arm, fingers, or shoulder * cervical postural assessment showing asymmetry (radiographic analysis, and posture observation) * chronic symptoms ≥ 1 year * pain and stiffness which limited range of motion in the cervical spine (flexion less than 60°) (extension less than 73°) (lateral flexion less than 13°-23° rotation less than 80°) * pain: moderate to severe level (≥5 on nprs) exclusion criteria: * • history of recent trauma to the cervical spine * any psychological condition * any specific cause of cervical radiculopathy (e.g., metabolic diseases, rheumatoid arthritis, osteoporosis) * central or peripheral neurological signs * history of spinal surgery.

Keywords: kendell exercise cervical spondylosis, postural abnormalities
music interventions during wide-awake hand surgery

Conditions: Anxiety; Surgery

Summary: the purpose of this study is to examine if patients have a lower anxiety level during wide awake hand surgery while listening to their choice of music vs standardized relaxation music. patients who are planning to undergo wide awake (local anesthetic only hand surgery) and agree to participate will be randomized to either a music intervention where they listen to their choice of music genre or standardized relaxation music during their time in the operating room. 170 participants will be enrolled and can expect to be on study for 2 weeks.

music has been shown to decrease anxiety and pain during surgery. wide awake local anesthesia no tourniquet (walant) surgery on the hand is gaining popularity due to efficiency, cost savings and patient safety. despite the popularity of walant, it still can be anxiety producing even for patients who choose to proceed with surgery without sedation. music has been shown to decrease anxiety during surgery, but patients' music choices vary widely. the frequency (hz) of the music intervention has been shown to impact pain reduction, and patient choice of music has been shown to increase sense of control which can decrease anxiety. no study has evaluated the intraoperative effect of patient choice of music vs standardized relaxation music on intraoperative anxiety. the primary objective of this research is to compare the effect of patient music choice vs standardized relaxation music played during surgery on anxiety levels in patients undergoing walant hand surgery. the investigators hypothesize that standardized relaxation music will result in reduced anxiety compared to patient's choice of music.

Eligibility criteria:
inclusion criteria: * adult (18 years of age or older) patients * undergoing wide awake local anesthesia no tourniquet (walant) hand surgery exclusion criteria: * patients under the age of 18 * patients unable to consent for themselves * patients unwilling to consent * non-english speaking patients * patients with significant hearing impairment not able to be corrected with assistive devices

Keywords: wide-awake hand surgery music intervention patient care
immune persistence after inoculated with one-dose freeze-dried live attenuated varicella vaccine in children vaccine in children

Conditions: Chickenpox

Summary: the purpose of this study is to observe the persistence of protection, duration of protection, safety and breakthrough infection rates afforded by live attenuated varicella vaccine in children over a 5-year period.


Eligibility criteria:
inclusion criteria: * participant are healthy children aged 1-6 years, who has inquired for medical history and physical examination, and met the requirement of the vaccine trial * parent/legal acceptable representative is willing and able to understand the protocol requirements and provide informed consent * subject and parent/guardian able to attend all scheduled visits and comply with all trial procedures * body temperature ≤37℃ exclusion criteria: * participant with previous history of chickenpox or zoster * receipt of varicella vaccine * reported the family history of allergies, convulsions, epilepsy and mental illness * known allergy to any constituent of the vaccine * known serve illness, in a fever, acute infection and chronic disease activity * receipt of steroid * reported the history of thrombocytopenia or other coagulation disorders, which may cause * known or suspected impairment of immunologic function, or receipt of immunosuppressive therapy or immunoglobulin since birth * known congenital malformation, developmental disorders and severe chronic disease (e.g. down's syndrome, diabetes, sickle cell anemia and neurologic disorders) * known dermatopathy with allergy, herpes, fester, and fungal infection * receipt of whole blood, blood plasma or immunoglobulin in the 3 months preceding the trial vaccination * reported the history of acute illness had need systemic antibiotics or anti-viral treatment of infections in the 7 days preceding the trial vaccination * participant with fever(temperature≥ 38℃) in the days * any condition, which, in the opinion of the investigator, would pose a health risk to the subject
pivotal study to evaluate the safety and efficacy of gelrinc for treatment of cartilage defects

Conditions: Articular Cartilage Defects in the Knee Joint

Summary: multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (gelrinc). this study compares the efficacy and safety of gelrinc to a historical control arm (microfracture) in the treatment of cartilage defects in the knee.


Eligibility criteria:
main inclusion criteria: * age between 18 and 50. * single contained symptomatic lesion located on the femoral condyle of the femur graded as icrs iii or iv with less than 5 mm of bone loss below the subchondral plate. * lesion size between 1 and 5 cm2 post debridement, less than or equal to 2.5 cm in diameter. * bmi ≤35 * contralateral knee is asymptomatic, stable, fully functional and not medically treated. main exclusion criteria: * presence of an additional grade iii or iv symptomatic lesion. * recent osteochondritis dissecans within 1 year of baseline visit. * untreated acl and/or pcl deficiency or complex ligamentous instability of the knee. * patient is excluded if presenting untreated current meniscal tear or if previous menisci resection was within the last 6 months. * previous tendon repair or ligament reconstruction within the last 6 months. * failed mosaicplasty or aci or maci or any other cartilage repair product. * microfracture performed less than 1 year before baseline visit.

Keywords: cartilage damage cartilage defect chondral lesion osteochondral lesion femur condyle
effect observation study of cox-2 inhibitor to treat primary hypertrophic osteoarthropathy

Conditions: Primary Hypertrophic Osteoarthropathy

Summary: the purpose of this study is to determine whether cox-2 inhibitor is effective in the treatment of primary hypertrophic osteoarthropathy

patients with primary hypertrophic osteoarthropathy(pho) were diagnosed based on clinical manifestations and symptoms. pho patients were treated with cox-2 inhibitor after signing informed consent. the extend of alleviation, the change of the markers on prostaglandin e metabolic pathway and the adverse event on different time points were recorded to identify the efficacy and safety.

Eligibility criteria:
inclusion criteria: * diagnosed with primary hypertrophic osteoarthropathy clinically * over 16 years old * no other medication intake * informed consent signed exclusion criteria: * below 16 years old * active gastric ulcer * inflammatory bowel disease * new york heart association classification（nyha） ii to iv * liver or renal failure * allergic to nonsteroid anti-inflammatory drugs * not willing to participate
evaluation of the role of tramadol 50mg as an analgesic during outpatient hysteroscopy

Conditions: Pain

Summary: the purpose of this study is to evaluate the role of tramadol 50mg in reducing pain during outpatient hysteroscopy.

this study is a prospective double blinded randomised controlled trial. 140 women will be recruited from the office hysteroscopy clinic in cairo university hospitals. all patients attending the outpatient hysteroscopy clinic will be invited to participate in the study. the invitation will include a clear full explanation of the study and patients will provide written consents. only patients consenting to participate will be included in the trial. tramadol and placebo will be enclosed in sealed envelopes which will be numbered using a computer generated random table. neither the patient nor the physician will be aware of the drug used. patients will be categorized into 2 groups: group i who will receive tramadol 50mg (tramadol, october pharma, giza, egypt) 1 hour before the procedure, group ii who will received a placebo acting as the control group. full history will be taken followed by general and local examination. the procedure will be done in the lithotomy position. hysteroscopy will be done using a 5mm outer diameter continuous flow hysteroscope with a french working channel and a 30 degrees direction of view provided by techno gmbh and co. the hysteroscope will be introduced using the vaginoscopy technique, in which no speculum will be used. the cervix will be detected and the external os will be identified using the hysteroscope. the hysteroscope will be introduced in the uterine cavity. saline will be used as the distension medium and the pressure will be set at 100mm hg. the anterior wall, posterior wall and tubal ostea will be visualized, any polyps, adhesions septa, congenital malformations or submucous fibroids will be noted. base line characteristics will be compared and the main outcome measure will be patients' pain perception during the procedure and 30 minutes later, this will be determined using a visual analogue scale.

Eligibility criteria:
inclusion criteria: * patients referred for outpatient hysteroscopy * consent to the procedure exclusion criteria: * premenstrual patients * known cardiac disease * known allergy to tramadol

Keywords: outpatient hysteroscopy tramadol
mobile application to create healthy food preparation habits for patients with diabetes and prediabetes

Conditions: Diabetes Mellitus, Type 2; Pre Diabetes

Summary: boston medical center (bmc) serves many underserved, low-income patients and has developed an innovative strategy to combat food insecurity including a preventative food pantry, a teaching kitchen, and a rooftop farm that provides fresh produce directly to the patients. the presence of this well-established, three-pronged approach places bmc in an ideal position to develop a nutritional education intervention that supports experiential learning in this high-risk population. for this first exploratory study, 75 enrolled participants will be given a free mobile application with recipes designed to build habits. participants will cook at least three meals weekly for two months using the app. self-reported survey data and activity on the app will be collected and used to assess the feasibility of teaching cooking skills through a mobile application.


Eligibility criteria:
inclusion criteria: * access to an oven or microwave, stovetop or hot plate, and food storage. * access to the internet on a smartphone * owns a smartphone with ios apple store or google play * reading proficiency in english * has a diagnosis of diabetes or prediabetes(hb a1c\> 5.6) exclusion criteria: * inability to provide informed consent * taking any medications or has a condition that limits the ability to increase intake of fruits and vegetables (including warfarin and end-stage renal disease) * attended a diabetes self-management education (dsme) at bmc within the past year or plans to attend during the study.

Keywords: mobile application meal preparations recipes
electronic record assimilation and subsequent eradication of hepatitis c

Conditions: Hepatitis C; Liver Diseases

Summary: given the disproportionately high risk of chronic hepatitis c virus (hcv) infection in the baby boomer cohort, population-based screening has been demonstrated cost effective. compared to point-of-care testing, however, bulk health messages with coupled lab requisitions delivered directly to patients meeting screening criteria via patient portals could improve hcv screening at minimal cost.

the centers for disease control and prevention (cdc) and the united states preventative services taskforce (uspstf) recommend a one-time hepatitis c infection (hcv) screen in individuals born 1945-65 (baby boomer birth cohort) and in others with risk factors for infection. national adherence to this grade b recommendation-carrying the same strength of evidence as mammography, and screening for depression, alcohol abuse, and type 2 diabetes-is estimated to be 13.8%. efforts to increase screening and linkage to hcv care, and also to understand barriers to screening and linkage are therefore warranted. one such intervention, direct-to-patient messages via electronic medical record (emr), has been demonstrated to improve adherence in influenza and pneumococcal vaccination, colon cancer screening, immunosuppression after transplantation, among others, but has not been studied as a strategy to improve hcv screening rates within health systems. our institution, stanford health care, comprises 86 distinct clinical sites with approximately 1.25 million outpatient visits per year. all clinical sites are linked with an emr (epic systems corp.) and patients are encouraged to opt-in to receive and send health-related messages through a secure internet and smartphone portal, myhealth. approximately 60% of patients at our institution are enrolled in myhealth. myhealth additionally allows bulk-messaging of patients meeting specific characteristics, e.g. patients due for influenza vaccination. bulk messages can be coupled with laboratory or radiology requisitions. messages are delivered through the online portal, text message, e-mail, and/or smartphone application notification, depending on patient preference. laboratory and radiology results are routed automatically to patients' primary care physicians for review. the investigators propose to conduct a randomized study comparing the effectiveness of a direct-to-patient electronic health message on hcv screening coupled with a lab requisition, versus hcv screening initiated by primary care clinicians as part of routine clinical care alone.

Eligibility criteria:
inclusion criteria: * persons born between 1945-1965 * having an activated patient portal to receive secure messages (myhealth) * no prior hcv antibody test within our ehr (electronic health record), including externally accessible results exclusion criteria: * documented hcv viral load in our ehr * diagnosis of chronic hcv in their problem list

Keywords: hepatitis c screening population health
to demonstrate the relative bioequivalency of cord's 100 mg desipramine hcl tablets to merrell dow's 100 mg norpramin tablets

Conditions: Depression

Summary: to demonstrate the relative bioequivalency of cord's 100 mg desipramine hcl tablets to merrell dow's 100 mg norpramin tablets.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.

Keywords: antidepressant