Kornimate/medical-research-clean huggingface dataset:
clinical and radiographic evaluation of the effect of hyaluronic acid surface treatment versus sandblasted acid etched on stability of delayed dental implant in posterior maxilla.

Conditions: Missing Teeth; Bone Loss

Summary: clinical and radiographic evaluation of the effect of hyaluronic acid surface treatment versus sandblasted acid etched on stability of delayed dental implant in posterior maxilla.

a dental implant is one of the procedures to restore missing teeth , to achieved the stability for implant success is the direct growth of bone to the implant surface, known as osseointegration.as a result, bone stability around dental implants is determined by factors that the implantologist may or may not directly influence, such as local bone quality and bone metabolism, as well as systemic factors such as age, systematic chronic diseases and lifestyle (e.g., smoking habits).treatment-related factors include augmentation material, implant design (macro and micro), surgical procedures, and loading protocols. therefore , it may be needed for a surface treatment could alter the topography, chemical content, and roughness of the surface and result in various biological reactions. the surface treatment can also increase the area of contact between the implant and the supporting bone . the rationale is evaluate increasing the implant stability around implants placed by using hyaluronic acid that act to improving the connection between implant and bone .sandblasting and acid etching is the most commonly used basic method for modifying the surface of dental implants . the sandblasting procedure "roughs up" the outer layer of the implant,creating a surface that is easier for the bone to grip as the implant heals.while hyaluronic acid and its derivatives have a strong chance of osseointegration and mineralization and have been utilized extensively for bone repair.

Eligibility criteria:
inclusion criteria: * patients with missing teeth in posterior maxilla. * both genders males and females will be included. * age from 18-60 years. exclusion criteria: * general contraindications to implant surgery. * subjected to irradiation in the head and neck area less than 1 year before implantation. * untreated periodontitis. * poor oral hygiene and motivation. * uncontrolled diabetes. * pregnant or nursing. * substance abuse. * psychiatric problems or unrealistic expectations. * severe bruxism or clenching. * immunosuppressed or immunocompromised. * treated or under treatment with intravenous amino-bisphosphonates. * active infection or severe inflammation in the area intended for implant placement. * unable to open mouth sufficiently to accommodate the surgical tooling. * patients participating in other studies, if the present protocol could not be properly followed.

Keywords: dental implant stability osseointegration hyaluronic acid sandblasted acid etched
effect of detrol la with behavioral intervention in overactive bladder subjects dissatisfied with recent oab medication.

Conditions: Urinary Incontinence

Summary: to evaluate the effect of tolterodine er in conjunction with behavioral intervention on subject satisfaction in oab subjects who were dissatisfied with their most recent antimuscarinic oab medication therapy.


Eligibility criteria:
inclusion criteria: * male and female subjects greater than or equal to 18 years of age * overactive bladder symptoms for at least 3 months * previously treated with antimuscarinic oab medications exclusion criteria: * participation in any professionally coached sessions (rn, np, pa or pt) teaching behavioral interventions
feasibility of randomizing danish citizens aged 65-79 years to high-dose quadrivalent influenza vaccine vs. standard-dose quadrivalent influenza vaccine in a pragmatic registry-based setting

Conditions: Influenza

Summary: the purpose of the study is to assess the feasibility of identifying, recruiting and randomizing a large sample of danish citizens aged 65-79 years to high-dose quadrivalent influenza vaccine or standard-dose quadrivalent influenza vaccine in the 2021/2022 influenza season in a registry-based setting using danish nationwide registries for all data collection including baseline information and outcome assessment.

to evaluate the feasibility of recruiting and randomizing danish citizens aged 65-79 years, we aim to randomize 40,000 citizens 1:1 to high-dose quadrivalent influenza vaccine or standard-dose quadrivalent influenza vaccine in a pragmatic, open-label, registry-based design using the infrastructure of danske lægers vaccinations service (dlvs), an organization responsible for numerous vaccination clinics in denmark, for recruitment and randomization and danish nationwide registries for data collection. citizens will be recruited by dlvs and randomized and vaccinated at the dlvs clinics. all collection of data related to baseline information, outcomes, and safety monitoring will be performed by a central trial site utilizing information from danish nationwide health registries. the findings of this pilot trial will indicate whether the conduction of a full-scale, adequately powered pragmatic rct is feasible within the danish registry-based framework.

Eligibility criteria:
inclusion criteria: 1. age 65-79 years 2. informed consent form has been signed and dated exclusion criteria: 1. allergy/hypersensitivity towards the influenza vaccines used in this study

Keywords: influenza vaccination pragmatic registry
comparison between the clinical assessment of the undescended testis and its' ultrasonographic size

Conditions: Undescended Testis

Summary: in addition to the manual preoperative examination, the undescended testicle will be measured ultrasonographically. the compared data will help us to evaluate the routine need for preoperative ultrasonographic evaluation of the undescended testicle.


Eligibility criteria:
inclusion criteria: * boys operated for unilateral cryptorchism exclusion criteria: * bilateral cryptorchism recurrent operation s/p inguinal operation
non-incised papilla flap in deep supraossous defects

Conditions: Periodontitis

Summary: the objective of this study was to assess the effectiveness of nipsa in periodontal lesions with deep supra-alveolar defects, measuring the clinical efficacy of this flap. the non-incised papilla surgical approach (nipsa) is a novel technique that accesses the periodontal defect from apical direction and was established with the aim of creating clinical advances compared with marginal access techniques. the defects with a supra-alveolar components are more frequent than intrabony defects, there is very little evidence about their treatment .


Eligibility criteria:
inclusion criteria: * diagnosis of periodontal disease (periodontitis stage iii and iv, grade a \[12\]; * non-smokers and former smokers who quit smoking at least 1 year previously * previous treatment for periodontal disease using non-surgical periodontal treatment completion of step i and ii of periodontal therapy * compliance with periodontal maintenance and oral hygiene (fmps at baseline ≤ 30%) * active residual pockets (positive bleeding on probing; bop) associated with intrabony defects that were not resolved with non-surgical treatment after 4-6 months of maintenance. * periodontal lesions with probing depth (pd) \> 6 mm and supraalveolar defect (pre-diagnosis clinically (periodontal probe) exclusion criteria: * systemic disease contraindicating periodontal surgery, * smokers, and * third molars or teeth with incorrect * endodontic or restorative treatment.
cox-2 inhibitor versus glucocorticoid versus both combined

Conditions: Rupture of Anterior Cruciate Ligament

Summary: recent studies on molar surgery have shown that a combination of a glucocorticoid and nsaid or cox-2 selective inhibitor gives better pain relief than either of the drugs used separately. the investigators group has also shown that adding dexamethasone on top of a regimen of paracetamol, nsaid and local anesthesia resulted in 45% painfree patients at rest after ambulatory breast cancer surgery. the goal of this study is to test the nsaid + glucocorticoid concept in acl repair. the investigators want to evaluate whether a selective cox-2 selective inhibitor or a glucocorticoid or a combination of both drugs, as part of a multimodal analgesic regime, can provide improved pain relief and shorter hospital stay in patients undergoing outpatient acl surgery.


Eligibility criteria:
inclusion criteria: * arthroscopic reconstruction of the anterior crucial ligament (acl) * at least 18 years old * asa i + ii exclusion criteria: * known renal impairment * liver failure and/-or an asthmatic condition * pregnancy * breast feeding

Keywords: arthroscopic reconstruction anterior crucial ligament coxib dexamethasone
gametocytocidal and transmission-blocking efficacy of pq in combination with al and tq in combination with spaq in mali

Conditions: Malaria,Falciparum

Summary: the purpose of this study is to compare the gametocytocidal and transmission reducing activity of artemether-lumefantrine (al) with and without a single dose of 0.25mg/kg primaquine (pq) and sulfadoxine-pyrimethamine with amodiaquine (spaq) with and without single dose of 1.66mg/kg tafenoquine (tq). outcome measures will include infectivity to mosquitoes at 2, 5 and 7 days after treatment, gametocyte density throughout follow-up, and safety measures including haemoglobin density and the frequency of adverse events.

full protocol available on request.

Eligibility criteria:
inclusion criteria: * age ≥ 10 years and ≤ 50 years * g6pd-normal defined by carestart rapid diagnostic test or the osmmr2000 g6pd qualitative test * absence of symptomatic falciparum malaria, defined by fever on enrolment * presence of p. falciparum gametocytes on thick blood film at a density \>16 gametocytes/μl (i.e. ≥ gametocytes recorded in the thick film against 500 white blood cells) * absence of other non-p. falciparum species on blood film * hemoglobin ≥ 10 g/dl * individuals weighing \< = 80 kg * no evidence of acute severe or chronic disease * written, informed consent exclusion criteria: * women who are pregnant or lactating (tested at baseline). urine and/or serum pregnancy testing (β-hcg) will be used. * detection of a non-p. falciparum species by microscopy * previous reaction to study drugs / known allergy to study drugs * signs of severe malaria, including hyperparasitemia (defined as asexual parasitemia \> 100,000 parasites / μl) * signs of acute or chronic illness, including hepatitis * the use of other medication (except for paracetamol and/or aspirin) * use of antimalarial drugs over the past 7 days (as reported by the participant) * clinically significant illness (intercurrent illness e.g., pneumonia, pre-existing condition e.g., renal disease, malignancy or conditions that may affect absorption of study medication e.g., severe diarrhea or any signs of malnutrition as defined clinically) * signs of hepatic injury (such as nausea and/or abdominal pain associated with jaundice) or known severe liver disease (i.e., decompensated cirrhosis, child pugh stage b or c) * signs, symptoms or known renal impairment * clinically significant abnormal laboratory values as determined by history, physical examination or routine blood chemistries and hematology values (laboratory guideline values for exclusion are hemoglobin \ 2.0mg/dl, or alt or ast more than 3 times the upper limit of normal for age. * blood transfusion in the last 90 days. * consistent with the long half-life of tafenoquine, effective contraception should be continued for 5 half-lives (3 months) after the end of treatment. * history of psychiatric disorders
efficacy of guedes-pinto paste and ctz paste in the non-instrumental endodontic treatment of primary teeth

Conditions: Necrotic Pulp

Summary: the maintenance of the deciduous tooth until its physiological exfoliation occurs is one of the main objectives of pediatric dentistry. endodontic treatment in deciduous teeth resulting from carious or traumatic lesions with pulpal involvement is often necessary and we often find it difficult to perform it, due to the difficult control of the child, the internal anatomy of the root canals, and root resorptions. the non-instrumental endodontic treatment technique (teni) associated with antimicrobial drugs has advantages such as shorter chair time and less complexity than the conventional technique in which root canal instrumentation is performed. the objective of this study is to carry out a controlled and randomized clinical trial to compare the effectiveness of non-instrumental endodontic treatment (niet) in primary teeth associated with the use of two filling pastes. 120 necrotic deciduous teeth of children aged between 3 and 6 years will be selected; and the teeth will be divided into two groups. in group 1 and group 2, the root canals will not be instrumented, just irrigated and filled with the respective pastes, ctz and guedes-pinto. the radiographic aspects will be evaluated, considering the repair process, clinically will be evaluated: presence of fistula and mobility, the evaluations will be carried out in both groups on the day of treatment and in periods of 1, 3 and 6 months after treatment. the data obtained will be submitted to the shapiro-wilk normality test, where the statistical analysis that will be used for this study will be defined, adopting a significance level of 95% (p\<0.05).


Eligibility criteria:
inclusion criteria: * patients aged 3 to 6 years old with at least one anterior deciduous tooth with pulp necrosis in a position to be restored and at least 2/3 of the remaining root. * healthy patients and who did not antibiotic treatment in the previous three months. exclusion criteria: • compromised health, primary teeth with more than one third root loss, lack of internal pathological resorption, impossibility of restoration, cases of re-treatment and crypt involvement.
ctc vs radiography as the evidence of recurrence in colorectal cancer patients

Conditions: Colorectal Cancer; Circulating Tumor Cell

Summary: this study enrolled patients who underwent r0 resection of tumor and had elevated tumor biomarkers (cea, ca19-9). after enroll the study, a ctc test will performed and patients who had positive ctc will be randomly assigned to two groups. the control group will continue follow-up until radiological recurrence appear, the treatment group will start treatment or change the current adjuvant regimen. first endpoint is os. the secondary endpoint is dfs, adverse event.


Eligibility criteria:
inclusion criteria: * age 18-80 years; histologically proven colorectal cancer all the lesion (s) has been r0 resected have elevated tumor biomarker (cea or ca19-9) in three consecutive tests more than 1 ctc has been detected (including 1) ecog 0-1 hematology tests suggest that they can tolerate chemotherapy written informed consent for participation in the trial exclusion criteria: * have any radiological evidence of recurrence other previous malignancy within 5 years
effect of blue light filtration on visual performance

Conditions: Cataract

Summary: the purpose of this study is to evaluate photostress recovery with blue light filter clip-on glasses among pseudophakes \[ie, subjects in which the natural lens of the eye has been replaced with an artificial lens (intraocular lens) during cataract surgery\]. this study will enroll subjects previously implanted with no blue light filter intraocular lenses (iols) for at least 3 months.


Eligibility criteria:
inclusion criteria: * cataract surgery in both eyes with no blue light filtering intraocular lenses for at least 3 months; * good ocular health; * 20/40 or better vision with best correction in both eyes; * willing to provide voluntary consent and sign informed consent form; * able to competently perform testing; * other protocol-defined inclusion criteria may apply. exclusion criteria: * ocular pathology, degeneration, or media opacity (cloudiness) that could impact study measurements; * other protocol-defined exclusion criteria may apply.

Keywords: cataract intraocular lens iol blue light filter
a study of beta-lactam in hospitalized patients with skin and skin structure infections

Conditions: Soft Tissue Infections

Summary: this 3 arm study will compare the efficacy and safety of beta-lactam with that of 'standard care' in patients with complicated skin and skin structure infections requiring hospitalization. patients will be randomized to receive 1)beta-lactam 750mg iv q8h 2)beta-lactam 1500mg iv q8h or 3)'standard care' \[prp (nafcillin or flucloxacillin) or vancomycin, plus aztreonam or ciprofloxacin\]. the anticipated time on study treatment is \<3 months and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * skin or skin structure infection requiring hospitalization; * clinical diagnosis of a skin or skin structure infection caused by bacteria known or suspected to be susceptible to the randomized study treatment; * material from site of infection is clinically purulent or seropurulent. exclusion criteria: * presenting with sustained shock (sbp\ 2 hours, despite adequate fluid resuscitation); * known or suspected concomitant bacterial infection requiring antibiotic treatment; * skin infection or chronic non-healing ulcer of \> 2 weeks duration; * patients in whom surgery is the primary treatment.
influence of chronic vascular diseases on transcranial doppler profiles in critically ill patients

Conditions: Respiration, Artificial; Sedated

Summary: the primary objective of this study is to show that cardiovascular risk factors associated with the chronic elevation of arterial resistance may be associated with "false" profiles of intracranial hypertension during transcranial doppler ultrasound of the middle cerebral arteries in intensive care unit patients. a "false" profile of intracranial hypertension is defined by a high pulsatility index without any intracranial pathology.


Eligibility criteria:
inclusion criteria for entry in the study: * sedated patient under mechanical respiratory assistance inclusion criteria for entry in group 1: the patient meets at least one of the following criteria: * the patient is a man over the age of 50 or a woman over the age of 60 * hypercholesterolemia (ldl \> 1.6 g/l, hdl \< 0.4 g/l) * arterial hypertension for over 10 years (treated or systolic arterial pressure \> 140 mmhg) * type 2 diabetes for over 10 years * active or former smoker in the past 3 years * history of cardiovascular event (peripheral artery disease, heart attack, stroke/transient ischemic attack over 3 months ago) * chronic renal insufficiency with mdrd \< 30 ml/min/1.73m\^2 inclusion criteria for entry in group 2: * the included patient is not in group 1 exclusion criteria: * acute neurological disorder (brain trauma, infectious or immune meningitis, meningoencephalitis, ischemic or hemorrhagic stroke \<3 months) * pregnant woman * person under guardianship * prisoners * recent carotid surgery (\<1 month)
micafungin prevention study for fungal disease in child receiving allogenic hematopoietic stem cell transplantation

Conditions: Neutropenia; Hematopoietic Stem Cell Transplantation; Invasive Fungal Disease

Summary: this study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. micafungin is administered until confirmation of neutrophil engraftment or treatment failure.

the purpose of this study is to evaluate absence of proven, probable, possible, suspected invasive fungal disease (ifds) through the end of prophylaxis therapy and during 4 weeks after stopping of micafungin prophylaxis after allogeneic hematopoietic stem cell transplantation in pediatric and adolescent neutropenia patients. patients will receive micafungin until the earliest of the following: 1) neutrophil engraftment; 2) development of proven, provable, possible or suspected invasive fungal disease; 3) development of unacceptable drug toxicity; 4) withdrawal from study participation or discontinuation of study treatment. safety profile of micafungin is also evaluated.

Eligibility criteria:
inclusion criteria: * patients will receive allogeneic hematopoietic stem cell transplantation exclusion criteria: * aspartate transaminase or alanine transaminase level \> 5 times unl * bilirubin \> 2. 5 times unl * history of allergy, sensitivity, or any serious reaction to an echinocandin * invasive fungal disease at the time of enrolment * systemic antifungal therapy within 72 hrs before administration of the first dose of study drug * positive pregnancy test

Keywords: pediatric adolescent micafungin
difluoromethylornithine (dfmo) chemoprevention of skin cancer in organ transplant recipients

Conditions: Post-solid Organ Transplant; Skin Neoplasms

Summary: this is a double blind, placebo controlled study of 52 patients who are at least one-year post-solid organ transplant. subjects will receive either 12 months of dfmo or a placebo. the specific aims are to determine if dfmo at 500 mg daily will be well tolerated for 12 months and not affect organ transplant viability; will inhibit 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced ornithine decarboxylase (odc) in skin biopsies by approximately 50% for the 12 months of therapy; and will be able to decrease polyamine levels in skin biopsies for the 12 months of treatment.


Eligibility criteria:
inclusion criteria: * \>1 year post-solid organ transplant of kidney, liver, pancreas, pancreas/kidney * adequate organ function * hearing age/gender appropriate * at high risk for developing skin cancer * immunosuppressant levels and doses show stable graft function exclusion criteria: * use of concomitant retin-a, efudex, accutane or psoralen and ultraviolet light a (puva) * systemic therapy for cancer treatment or prophylaxis * use of concomitant azathioprine, antiseizure medications, non-steroidal anti-inflammatory drugs \[nsaids\] (other than cardioprotective doses of aspirin)