Kornimate/medical-research-clean huggingface dataset:
perioperative use of atosiban for ultrasound-indicated cerclage to reduce spontaneous preterm birth(sptb)

Conditions: Cervical Cerclage; Premature Birth

Summary: after ultrasound-indicated cerclage, some pregnant women still experience sptb, and there is controversy regarding the use of tocolytic agents during the perioperative period to reduce the incidence of sptb. in this study, the investigators employed a randomized double-blind method to investigate whether the use of atosiban during the perioperative period can reduce the incidence of sptb before 34 weeks.


Eligibility criteria:
inclusion criteria: * (i) viable singleton gestation between 14 0/7 and 23 6/7 weeks of gestation. * (ii) previous history of miscarriage or preterm labor in mid-pregnancy. * (iii) transvaginal ultrasound examination showed that the cervix is 25mm or less at gestations less than 24 weeks. exclusion criteria: * (i) women with uterine contractions. * (ii) vaginal bleeding. * (iii) symptoms of chorioamnionitis. * (iv) medically indicated ptb (severe preeclampsia, placental abruption, preterm premature rupture of membranes). * (v) major structural or chromosomal abnormalities. * (vi) contraindication to atosiban. * (vii) had received atosiban or any tocolytic agents within 7 days before their presentation.
multi-gyn florafem study for treatment of vulvo vaginal candidiasis symptoms

Conditions: Vulvovaginal Candidiasis

Summary: women diagnosed with vulvovaginal candidiasis by the health care professional will be enrolled in the study. all participants should fulfil inclusion and exclusion criteria. the study product will be used for 5 days, once a day. the doctor will evaluate the patients before and at the end of the treatment.


Eligibility criteria:
inclusion criteria: * women diagnosed with vulvovaginal candidiasis confirmed by:itching, and/or burning, irritation, edema, redness, crumbly white discharge * aged \>18 years * signed written informed consent form * willing to comply to the follow-up schedule * subject affiliated to a health social security system. * female of childbearing potential should use a contraceptive regimen recognized as effective since at least 12 weeks before screening visit, during all the study and at least 1 month after the study end. exclusion criteria: * current clinically manifest of sexually transmitted gynecologically infection, genital tract infection, bacterial vaginosis or aerobic vaginitis (incl. clinical obvious gonorrhoea, chlamydia trachomatis or mycoplasma genitalium infection with cervicitis, urethritis, salpingitis) * current genital malignancies * chemotherapy for any reason in last 6 months * radiotherapy in the genitourinary system in the last 12 months * pregnancy or currently attempting to conceive * lactation * use of other treatment for vaginal conditions during the course of the clinical investigation * known allergies to ingredients of the product * concomitant medication for treatment of vaginal infections, or other use of intravaginal medication during the course of the clinical investigation
evaluation of gel and solution of chlorhexidine in disinfection root canals of primary anterior teeth.

Conditions: Dental Caries; Infection, Bacterial; Tooth, Deciduous

Summary: the process of removing bacteria and their products from the root canals is an essential step that is achieved through the combination of mechanical preparation and irrigation with chemicals. however, mechanical preparation alone can not reduce the microbial formations inside root canals, so at least about 35% of the root canal walls remain without the preparation tools reaching them. many irrigants were used to irrigate the root canals, as sodium hypochlorite and chlorhexidine are the most famous. although most studies have proven the effectiveness of sodium hypochlorite with its different concentrations in accomplishing this task, some of them showed the inability of the irrigant fluid to eliminate enterococcus faecalis inside the canals. these bacteria are highly resistant, and therefore endodontic treatment fails in the long term.

bacteria and their products play an essential role in the initiation and persistence of endodontic diseases. therefore, eliminating them and preventing the return of their effectiveness is the desired goal in any successful endodontic treatment in the short and long term. due to the fact that mechanical preparation of the root canal alone is not capable of removing the entire bacterial content, chemical irrigants were considered necessary to reduce the number of bacteria and toxins resulting from them. until now, there is no irrigant capable of removing the entire bacterial content from the root canal. despite the many advantages of sodium hypochlorite, several studies have revealed the toxicity of the solution in high concentrations of it, and it tends to cause tissue irritation when it comes into contact with the apical tissues. chlorhexidine has been used for a long time in dentistry due to its antibacterial properties, long period of effect, and relatively low toxicity. this has prompted its use as an irrigant and an intra-canal dressing in endodontic treatment.

Eligibility criteria:
inclusion criteria: 1. definitely positive or positive ratings of frank scale. 2. physiological root resorption no more than the apical third 3. symptoms or signs of pulpal necrosis with or without radial lesions (swelling - fistua - abnormal movement). 4. at least 2 mm of bone surrounding the permanent bud. 5. children who have not taken antibiotics in the past 3 months. exclusion criteria: 1. systematic or mental disorders. 2. definitely negative or negative ratings of frankel scale 3. existence external or internal abnormal absorption.

Keywords: anterior primary tetth infected canals chlorhexidine sodium hypochlorite
packing of perianal abscess cavities trial: a randomised multicentre trial comparing packing with non-packing of the abscess cavity

Conditions: Perianal Abscess

Summary: the aim of this study is to compare the effect of packing and non-packing on the healing rate of perianal abscess cavities. secondary objectives are to assess quality of life, cost effectiveness and rate of abscess recurrence and fistula-in-ano formation. if there is no difference in time to healing and non-packing is shown to be safe, acceptable to the patient and cost effective, this approach may become more widely accepted.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute primary perianal abscess * have undergone surgical incision and drainage as an emergency exclusion criteria: * the abscess is the sequelae of concurrent disease or trauma * fourniers gangrene is suspected * unable to give informed consent
endocardial mapping with the coremap ep mapping system

Conditions: Persistent Atrial Fibrillation

Summary: this is a global, multi-site, prospective, feasibility study.

the inveni study consists of three phases. for phase 1, the goal is to collect and analyze high fidelity endocardial electrograms (egms) in patients with persistent and long-standing persistent af. for phase 2, the goal is the initial development and evaluation of a coremap-guided tailored ablation strategy and to demonstrate safety and chronic efficacy of the coremap ep mapping system. for phase 3, the goal is the evaluation of a coremap-guided tailored ablation strategy and to demonstrate both chronic safety and effectiveness in de novo peraf patients.

Eligibility criteria:
inclusion criteria: 1. subject has persistent or long-standing persistent af, at the discretion of the investigator 2. subject is 18 to 80 years of age 3. patient scheduled for standard of care af ablation 4. subject is able to provide written informed consent 5. subject is able and willing to complete all study procedures exclusion criteria: 1. any of the following within three months of enrollment: 1. myocardial infarction (mi) 2. any surgical or percutaneous cardiac procedure including coronary intervention and cardiac ablation 3. confirmed thrombus on imaging 2. any of the following within six months of enrollment: a) cardiac surgery including coronary artery bypass grafting, ventriculotomy, atriotomy b) thromboembolic event (stroke) 3. any of the following cardiac conditions: 1. new york heart association (nyha) iv 2. left ventricular ejection fraction (lvef) \< 30% 3. carotid stenting or endarterectomy 4. atrial or ventricular septal closure or left atrial appendage closure 5. implanted permanent pacemaker, biventricular pacemaker, or any type of implantable cardiac defibrillator 6. presence of intramural thrombus, tumor (including atrial myxoma), or other abnormality that precludes vascular access, catheter introduction, or manipulation 7. unstable angina 8. prior mitral or tricuspid valve surgery, repair, prosthetic or mechanical valve 9. moderate to severe mitral valve stenosis or other severe valvular disease 10. any blood clotting or bleeding abnormalities 4. contraindication to systemic anticoagulation 5. af secondary to electrolyte imbalance, acute alcohol intoxication, or reversible or non-cardiac cause 6. body mass index (bmi) \> 40 kg/m2 7. severe pulmonary disease, pulmonary hypertension, or any chronic respiratory condition 8. renal failure requiring dialysis or transplant 9. acute illness, active systemic infection, or sepsis 10. active drug or alcohol dependency 11. any contra-indication that may extend procedure time, at the discretion of the operator 12. any woman known to be pregnant or breastfeeding, or any woman of childbearing potential who is not on a reliable form of birth regulation method or abstinence 13. subject considered part of vulnerable population 14. life expectancy less than one year 15. employee of the study site or sponsor 16. subjects who are currently enrolled in another study that would directly interfere with this study
comparison between anterior segment optical coherence tomography and ultrasound bio microscopy parameters in glaucoma assessment

Conditions: Glaucoma Eye

Summary: study aiming to compare between anterior segment optical coherence tomography and ultrasound biomicroscopy in glaucoma assesment

glaucoma is comprised of a group of optic neuropathies that share certain biological and clinical characteristics including progressive loss of the rgcs that causes specific, irreversible changes to the optic disc and visual field visualization of the anterior chamber (ac) angle is a critical step in the diagnosis of glaucoma, especially angle-closure variants. . ubm has been used in imaging and quantitative evaluation of anterior ocular segments since the 1990s. it allows in vivo observation of the anatomy and pathology of the anterior segments, from the conjunctiva and cornea to the iris and basal vitreous body, which provides significant information on glaucoma, cysts, neoplasms, trauma and foreign bodies. ubm also provides biometric information of anterior segment structures, such as anterior chamber (ac) depth, anterior chamber angle (aca), and iris thickness. ubm provides more detailed information compared to slit-lamp, gonioscopy or b-scan examinations for diagnosis and follow-up of pac eyes.in some cases ubm elucidates the mechanism of elevated intraocular pressure by showing the relationship between the peripheral iris and the trabecular meshwork. it can be used to study the causes of secondary glaucoma, for example, the pigment dispersion syndrome, lens-induced glaucoma, ciliary block, cysts, and solid tumors of the anterior segment. it can also assess the effects of various interventions such as laser iridotomy, trabeculectomy, and non-penetrating drainage surgery. precise quantitative evaluation of the anterior chamber angle structures can help in diagnosis and management of various pathologies related to glaucoma . optical coherence tomography (oct) is a widely used non-invasive fundus imaging technique. since the first application of oct in the cornea in 2002\], anterior segment-optical coherence tomography (as-oct) has developed rapidly. there are two major oct platforms on the market: time domain-optical coherence tomography (td-oct) and spectral (or fourier) domain-optical coherence tomography (sd/fd-oct) . with a higher imaging resolution than ubm, as-oct makes it easier for the operator and software to identify aca structures. such as: the scleral spur (ss), iris surface, schwalbe's line, even trabecular meshwork (tm), and schlemm's canal. this provides more precise analysis of the angle opening distance (aod) from the ss, aca, trabecular iris angle (tia), and trabecular iris space area (tisa)

Eligibility criteria:
inclusion criteria: * patients with open and angle closure glaucoma. male and female patients were included. patient age: more than18 years old exclusion criteria: previous glaucoma surgery. previous cataract surgery. media opacity. associated ocular or intra ocular inflammation. associated corneal pathology.
a clinical study on acuris™ - conometric concept for single tooth restoration

Conditions: Jaw, Edentulous, Partially

Summary: the purpose of this study is to evaluate the outcome of prosthetic survival of the acuris conometric concept 1 year after permanent restoration, since this is a new mode of retention using friction for seating the crown of single tooth restorations without using cement or screws.


Eligibility criteria:
inclusion criteria: 1. subject aged between 18-75 years 2. subject signed and dated the informed consent form 3. in need of an implant replacing a missing tooth in position 17 to 27 or 37 to 47, and each subject can only receive one study implant. 4. neighbouring tooth to the planned implant must have * a natural root or an implant supported restoration mesially * a natural root or an implant supported restoration distally exemption: if the planned implant is in the second molar position, an edentulous space is accepted distally. 5. presence of natural tooth, partial prosthesis and/or implant supported restoration in the opposite jaw in contact with the planned crown 6. deemed by the investigator as likely to present an initially stable implant situation exclusion criteria: 1. unlikely to be able to comply with study procedures, according to investigators judgement 2. subject is not willing to participate in the study or not able to understand the content of the study 3. involvement in the planning and conduct of the study 4. severe non-compliance to cip as judged by the investigator and/or dentsply sirona implants. 5. unable or unwilling to return for follow-up visits for a period of five years 6. simultaneous participation in another clinical study, or former participation in a clinical study during the last 6 months that may interfere with the present study 7. previous enrolment in the present study 8. uncontrolled pathological process in the oral cavity 9. known or suspected current malignancy 10. history of radiation therapy in the head and neck region within 12 months prior to surgery 11. systemic or local disease or condition that could compromise post-operative healing and/or osseointegration 12. uncontrolled diabetes mellitus 13. corticosteroids, iv bisphosphonates or any other medication that could influence post-operative healing and/or osseointegration 14. current need for major bone grafting and/or augmentation in the planned implant area (minor grafting and soft tissue grafting are allowed) 15. present alcohol and drug abuse 16. smoking more than 10 cigarettes per day exclusion criteria at visit 5 (permanent restoration) 17. permanent restoration delivered later than 6 months after implant placement
analyzing the composition of tears to identify cancer

Conditions: Breast Cancer; Ovarian Cancer; Colon Cancer; Benign Disease

Summary: this study will further evaluate the use of protein identification or protein pattern (signature) found in tears. we hypothesize that differences exist between the protein profile in tear fluid from patients with versus without cancer.

specifically, this study will compare the protein profile in tear fluid from patients with breast, ovarian or colon cancer versus "normal male and female patients" for differences that show promise as a diagnostic indicator. if such differences can be found, then their diagnostic potential will be assessed and developed further in a subsequent study. the long-term goal of this project will be to develop a screening tool for the detection of breast and/or other cancers.

Eligibility criteria:
inclusion criteria: * female or male, 18-100 years old * patients who present for a routine check-up * patients who present for the evaluation of an abnormal exam or test (mammogram, ultrasound, mri, pet, etc.) * may or may not have a mass present * patients who present for the evaluation of a palpable lump or mass * patients may be pre or post biopsy for a mass, as long as there is a portion of the mass remaining exclusion criteria: * patient \ 100 y/o * concurrent eye infection or trauma * active conjunctivitis * abnormal production of tears (too much or too little)

Keywords: screening tool for cancer
an investigational scan (64cu-dota-trastuzumab pet/mri) in imaging patients with her2+ breast cancer with brain metastasis

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain

Summary: this clinical trial examines an investigational scan (64cu-dota-trastuzumab positron emission tomography \[pet\]/magnetic resonance imaging \[mri\]) in imaging patients with her2+ breast cancer that has spread to the brain (brain metastasis). diagnostic procedures, such as 64cu-dota-trastuzumab pet/mri, may help find her2+ breast cancer that has spread to the brain and determine whether cancer in the brain takes up trastuzumab, which may predict for response to trastuzumab deruxtecan (the standard of care chemotherapy).

primary objectives: i. evaluate the feasibility of 64cu-dota-trastuzumab pet imaging in patients with her2+ breast cancer metastatic to the brain. ii. evaluate if her2+ breast cancer patients with brain metastasis who are responders to fam-trastuzumab deruxtecan have higher maximum standardized uptake value (suvmax) (minimum over all lesions in the brain) than non-responders. secondary objective: i. evaluate if the minimum suvmax of all quantifiable lesions in a given patient is associated with time to progression in the brain. outline: patients receive trastuzumab intravenously (iv) over 15 minutes on day 0. patients then receive 64cu-dota-trastuzumab iv and then undergo pet/mri scan on day 1. patients undergo repeat brain mri every 6 weeks for 24 weeks and then every 9 weeks until disease progression. patients then receive trastuzumab deruxtecan iv every 21 days in the absence of disease progression or unacceptable toxicity.

Eligibility criteria:
inclusion criteria: * documented informed consent of the participant and/or legally authorized representative * women with documented metastatic her2 positive breast cancer (american society of clinical oncology \[asco\] college of american pathologist \[cap\] guidelines) who have brain metastases * age \> 18 years * eastern cooperative oncology group (ecog) 0-2 * patients with leptomeningeal disease will be considered eligible * planned therapy with fam-trastuzumab deruxtecan * left ventricular ejection fraction (lvef) \> 50% * absolute neutrophil count (anc) \> 1.5 x 10\^9/l * platelets \> 100 x 10\^9/l * hemoglobin \> 9 g/dl * total (t.) bilirubin \< 3 x upper limit of normal (uln) * aspartate aminotransferase (ast) and alanine aminotransferase (alt) \< 5 x uln * creatinine clearance \> 30 ml/min (by cockcroft-gault formula) * activated partial thromboplastin time (aptt) \< 1.5 x uln * prior therapy for central nervous system (cns) disease is allowed, but at least 1 lesion \> 1.5 cm is evident on mri exclusion criteria: * need for immediate local intervention for brain metastases * noninfectious interstitial lung disease or pneumonitis requiring glucocorticoids * clinically significant corneal disease * myocardial infarction \< 6 months before, congestive heart failure (chf), unstable angina, or serious cardiac arrhythmia
success rate of the miniscrews in the mandibular buccal shelf

Conditions: Class III Malocclusion

Summary: stability of the orthodontic miniscrews placed in the mandible is still considered to bare higher risk of failure compared to other intraoral locations. the aim of our study was to determine the influence of the miniscrew size on their long-term stability, occurrence of oral mucosa inflammation and pain lasting over 48 hours after implantation.


Eligibility criteria:
inclusion criteria: * generally healthy caucasians * mild class iii maloclussion that required an absolute anchorage for en-masse distalization in the mandible * hypodivergent or normal angle between the maxillary and mandibular planes * excellent oral hygiene exclusion criteria: * hyperdivergent angle between the maxillary and mandibular planes * unfavorable anatomical conditions - e.g. presence of a strong frenulum potentially irritating the miniscrew head during chewing and/or facial movement

Keywords: miniscrew orthodontics skeletal anchorage
prospective registry on vascular access in interventions in lazio region

Conditions: Postoperative Hemorrhages

Summary: previous randomised studies showed that radial artery catheterisation for percutaneous cardiovascular procedures has a superior safety profile than femoral access, however the confirmation of these benefits in the real world by a large, specific, observational study is still lacking. we endeavoured to assess the access site-related outcomes of any percutaneous cardiovascular procedure by designing a prospective registry monitoring a consecutive sample of patients in a short period of time at nine roman hospitals reflecting the contemporary state of health care.


Eligibility criteria:
inclusion criteria: * all patients undergoing any percutaneous cardiovascular procedure exclusion criteria: * patients already enrolled in other clinical trials

Keywords: radial femoral artery invasive cardiology safety
rehabilitation of conversion gait disorder

Conditions: Conversion Disorder

Summary: evaluating the effects in functional status after three weeks of cognitive - and behavioural rehabilitation on patients with gait disorder. the patients are followed up as after 1 and 12 months to study if any improvement is still present. the patients are being recruited from neurological units. the intervention is explanation of symptoms, positive reinforcement of normal behaviour and absence reinforcement of dysfunctional behaviour. in addition the study aims at describing typical gait patterns at patients with gait disorder by using biomechanical measurements (ekg).

patients are being recruited from neurological unit/ div and out patients department of ssr and are randomized to treatment or control group. essential gait disorders do to conversion symptoms and willingness to participate in either of the two groups with informed consent are required.

Eligibility criteria:
inclusion criteria: * to determine the changes in functional status after three weeks of multidisciplinary rehabilitation in patients with conversion walking disorder. exclusion criteria: * essential gait disorders do to conversion symptoms and willingness to participate in either of the two groups with informed consent are required.