Kornimate/medical-research-clean huggingface dataset:
melatonin levels on covid-19 positive pregnant women

Conditions: COVID-19 Acute Respiratory Distress Syndrome; Pregnancy Related; Pregnancy Complications

Summary: this study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe covid-19 infection in pregnant women. four study groups were formed, including pregnant women with a positive covid-19 pcr test, severe symptoms, and inpatient treatment. pregnant women who had complaints similar to covid-19 infection or had no complaints, but had a pcr test due to the surveillance program and negative test results were included in the control group. methods and main outcome measure: laboratory values of the cases at the time of diagnosis parameters were collected. melatonin levels decrease in pregnant women with covid-19 symptoms, the severity of symptoms increases. in addition, patients with low melatonin levels have an increase in infection parameters and an increase in the hospital stay.

a total of 228 pregnant women included in this prospective controlled study between june 20021 and june 2022 at gynecology and obstetrics department of health sciences university samsun training and research hospital.

Eligibility criteria:
inclusion criteria: * pregnant women with a positive covid-19 pcr test and severe symptoms and inpatient treatment. pregnant women who had complaints similar to covid-19 infection or had no complaints but had a pcr test due to the surveillance program and negative test results were included in the control group. pregnant women who had contact with people with covid-19 infection and had a pcr test due to the surveillance program and had positive results, but no complaints were included in the other study group. the pcr test of pregnant women who had complaints and needed inpatient treatment during the covid-19 infection was confirmed, and the covid-19 infection was graded according to who's criteria. pregnant women with viral infection with symptoms compatible with infection and virus isolation in any culture samples collected at admission were included in the patient group with pcr positive mild-moderate and severe covid-19 infection.

Keywords: covid-19 sars-cov-2 melatonine pregnancy pregnancy outcomes
remediation of emotional processing deficits in ms

Conditions: Multiple Sclerosis

Summary: this study will test the effectiveness of an emotional processing intervention in individuals with ms in a double blind placebo controlled randomized clinical trial. we will utilize an intervention which has been successfully used in other populations, including schizophrenia and traumatic brain injury. our pilot data shows that this intervention is effective in individuals with ms as well

this study will test the effectiveness of an emotional processing intervention in individuals with ms in a double blind placebo controlled randomized clinical trial rct). we will utilize an intervention which has been successfully used in other populations, including schizophrenia and traumatic brain injury. our pilot data shows that this intervention is effective in individuals with ms, as well. all participants will undergo a baseline evaluation assessing emotional processing abilities, cognitive functioning, and psychological functioning. participants will then be randomized into two groups. during the treatment phase, the experimental group will receive the proposed intervention while the control group will receive a "placebo" treatment. neuropsychological assessment will be repeated at the end of the intervention.

Eligibility criteria:
inclusion criteria: * between the ages of 18-65. * diagnosis of relapsing-remitting multiple sclerosis. * can read and speak english fluently. exclusion criteria: * history of prior stroke or other neurological disease or injury. * history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of major depressive disorder, schizophrenia, epilepsy, bipolar disorder. * significant alcohol or drug abuse history.

Keywords: emotional processing multiple sclerosis cognition
wound bacterial microbiota and their antibiotic resistance

Conditions: Wounds and Injuries; War-Related Injuries; Wound Infection; Wounds, Penetrating; Wounds, Gunshot; Arm Injuries; Leg Injuries; Soft Tissue Injuries

Summary: the purpose of the study is to explore the microbiology in war-associated wounds of hospitalized patients from the syrian armed conflict. cultures collected from acute wounds with clinical signs of infection will be analyzed.

war-associated injuries often result in soft tissue and bone being contaminated with foreign material, leading to infection (fares et al. 2013; covey, lurate, and hatton 2000). wound infections remain the greatest risk to life and restoration of function in war-wounded that survive the first few hours (tong 1972; murray 2008). the syrian armed conflict broke out in 2011 and quickly deteriorated. médecins sans frontières/doctors without borders (msf) runs an emergency trauma project in the ministry of health hospital in ar ramtha, jordan, less than five kilometers from the syrian border. at this facility patients from the syrian armed conflict receive treatment for blast- and gunshot-injuries. wounds are treated according to the international committee of the red cross war surgery protocol (giannou and baldan 2010). wound management and healing has been difficult and time consuming, often complicated by infections and antibiotic resistance. recommendations for treatment of war-associated infections are generally not supported by cohort studies (murray et al. 2008). high rates of war wound infections caused by antimicrobial drug resistant organisms have been shown in the middle east but reports generally only include combatants. due to the use of body armor and forward medical therapy this data may not be applicable to a civilian setting. furthermore, available studies are either performed on old wounds (teicher et al. 2014) or on all available culture samples, disregarding infection signs (sutter et al. 2011; dau, tloba, and daw 2013). without clinical signs of infection, routine collection of peri-debridement culture samples is inappropriate in war-associated injuries (murray et al. 2008). the differentiation between contamination and infecting organisms is crucial in order to avoid unnecessary medication, especially limit the use of broad-spectrum antibiotics as overuse may lead to development of multi-drug resistant organisms (eardley et al. 2011). cultures collected from acute wounds with clinical signs of infection will be analyzed.

Eligibility criteria:
inclusion criteria: * patients that receive surgical treatment for war-associated injuries, irrespective of injury location, injury mechanism, time from injury and prior treatment * patients that receive treatment during the study period and are later re-admitted will only be counted as one patient exclusion criteria: * patients that are only re-admitted during the study period, i.e. patients that received primary treatment by msf before study initiation
safety and efficacy of fe 999326 administered intravesically to japanese subjects with high-grade, bcg unresponsive, non-muscle invasive bladder cancer (nmibc)

Conditions: Bladder Cancer

Summary: to evaluate the safety and efficacy of fe 999326 in japanese subjects with high-grade, bcg unresponsive nmibc.


Eligibility criteria:
inclusion criteria: * have at entry, confirmed by a pathology report: 1. carcinoma in situ (cis) only 2. ta/t1 high-grade disease with concomitant cis or 3. ta/t1 high-grade disease without concomitant cis * subjects who did not respond to bcg treatment and have a persistent high-grade recurrence within 12 months after bcg was initiated, and those who despite an initial complete response to bcg, relapse with cis within 12 months of their last intravesical treatment with bcg or relapse with high-grade ta/t1 nmibc within 6 months of their last intravesical treatment with bcg. * life expectancy \>2 years, in the opinion of the investigator * eastern cooperative oncology group (ecog) status 2 or less * absence of concomitant upper tract urothelial carcinoma or urothelial carcinoma within the prostatic urethra * subjects with prostate cancer on active surveillance at low risk for progression, defined as prostate-specific antigen (psa) \<10 ng/dl exclusion criteria: * current or previous evidence of muscle invasive (muscularis propria) or metastatic disease presented at the screening visit. * current systemic therapy for bladder cancer * current or prior investigational treatment for bcg unresponsive nmibc or any other investigational drug within 1 month prior to screening * current or prior pelvic external beam radiotherapy within 5 years of entry * use of other adenovirus vector medications, including covid-19 vaccines, within 2 weeks before and after instillation * history of malignancy of other organ system within past 5 years, except treated basal cell carcinoma or squamous cell carcinoma of the skin and ≤pt2 upper tract urothelial carcinoma at least 24 months after nephroureterectomy. * subjects who cannot hold instillation for 1 hour * subjects who cannot tolerate intravesical dosing or intravesical surgical manipulation * intravesical therapy within 8 weeks prior to beginning trial treatment, with the exception of: * cytotoxic agents when administered as a single instillation immediately following a turbt procedure * previous intravesical bcg therapy * systemic immunosuppressive therapy within 3 months prior to screening
gait analysis of hemiparetics adults patients with quadripod cane and rolling cane

Conditions: Stroke; Hemiplegic Gait

Summary: after stroke, a lot of patients present an hemiparesis and gait disorders. they need walking aids like quadripod cane or rolling cane. the quadripod cane confers a great stability but implies a walk in 3 times, thus consume more energy. the pause time necessary for the displacement (uplift) of the cane disappear with the wheeleo. the investigators will study many spatio-temporal parameters to determine which one allows to decrease the walking speed.

hemiparesis affects 65% of stroke patients and cause gait disorders. during rehabilitation, patients often need technical aids to the the return to walk. for example, they can use the quadripod cane and the rolling cane, called wheeleo. regarding the first one, as its name indicate, there are 4 feet while the other model has 4 wheels. deltombe and al. proved that the walking speed is higher with a rolling cane. the investigators will recruited stroke patients and study many spatio-temporal parameters with a gait analysis system, when participants are walking with the two walking aids. participants will achieve 6 minutes walking test and a 10 meters walking test, with a wearable inertial systems on their shoes. the investigators wish to reveal which spatio-temporal parameters most influence walking speed.

Eligibility criteria:
inclusion criteria: * age \> 18 years * hemiparesis following a stroke * be able to walk with a quadripod cane independently * be able to walk with the rolling cane independently * be able to follow instructions exclusion criteria: * cognitive impairment * acute orthopedic impairment * other pathologies affecting walking (parkinson's disease, severe polyneuropathy,...)
impact of mixed reality training on motor skills in children with autistic spectrum disorder

Conditions: Autistic Spectrum Disorder

Summary: people with autistic spectrum disorder frequently present impaired motricity, or at least different motricity from neurotypical subjects (walking; postural balance; fine motor skills; motor control, etc.). motor impairment can have impact on the performance and learning of simple tasks (bathing, dressing, writing, using tools, etc.), especially in children and teenagers. these last years, new therapeutics such as virtual, augmented and mixed reality technologies have developed. their therapeutic interest has been identified in various pathologies like phobia. however, their influence on motor skills has been little studied. the first results obtained with disabled adults described a significant increase in walking speed after a 3-month mixed reality training.

the aim of the study is to assess the impact of mixed reality training on motor skills of children with autistic spectrum disorder.

Eligibility criteria:
inclusion criteria: * aged between 8 and 12 years old * with autistic spectrum disorder * male or female * agreeing to participate in the study exclusion criteria: * visually impaired or blind. * traumatism and physical injuries * epilepsy

Keywords: autistic spectrum disorder motor skills mixed reality training
exercise in severe mental illness. the psychiactive project

Conditions: Exercise Therapy

Summary: the purpose of this randomized controlled trial is to study the effects of exercise on body weight, body composition, anthropometric and fasting blood measures, physical fitness, pulmonary function, quality of life, and lifestyle habits in patients with severe mental illness.


Eligibility criteria:
inclusion criteria: patients with severe mental illness established by experienced psychiatrists, aged 18 years or older and stabilized on antipsychotic medication during the last month. exclusion criteria: patients with clinical instability, co-morbid substance abuse, or evidence of uncontrolled cardiovascular, neuromuscular and endocrine disorders.
long-term oncologic outcome of breast-conserving surgery in breast cancer patients with brca1/2 mutations

Conditions: BRCA1/2 Mutation; Breast-conserving Surgery

Summary: the investigators matched bcs and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with brca 1/2 mutations.

the purpose of study is to assess the oncologic safety of bcs in patients carrying brca1/2 mutations by comparing long-term outcomes with mastectomy. the investigators matched bcs and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. by providing insights into the feasibility of bcs for patients with brca1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.

Eligibility criteria:
inclusion criteria: * primary invasive breast cancer who underwent bcs or mastectomy * received a brca1/2 mutation test exclusion criteria: * patients with de novo metastasis * pregnancy-associated breast cancer
effect of rosiglitazone on carotid intima media thickness in patients with insulin resistance syndrome and/or type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the study investigated the effect of rosiglitazone and placebo on carotid intima media thickness in patients with insulin resistance syndrome and/or type 2 diabetes.

ras rosiglitazone and atherosclerosis study: a 1 year randomised, double-blind, parallel group, placebo controlled study to evaluate the efficacy of rosiglitazone on the progression of intima-media thickness in the carotid artery in subjects with insulin resistance syndrome and/or type 2 diabetes mellitus

Eligibility criteria:
inclusion criteria: * insulin resistant syndrome or type 2 diabetes. exclusion criteria: * use of \>= 2 concomitant oral antihyperglycaemic agents within 3 months of study start. * initiation of anti-hypertensive or lipid lowering therapy \<= 6 months prior to study start or who increased the dose 3 months prior to study start. * unstable or severe angina or congestive heart failure nyha class i-iv, history of acute myocardial infarction or stroke within last 6 months. * any history of surgical intervention in the right carotid artery. * clinically significant hepatic disease. * creatinine clearance \<40ml/min.

Keywords: rosiglitazone type 2 diabetes intima media thickness insulin resistance
self-management assistance for recommended treatment (smart) portal

Conditions: Crohn's Disease; Ulcerative Colitis; Indeterminate Colitis; Inflammatory Bowel Disease

Summary: the purpose of the study is to develop, evaluate, and optimize an interactive website (the smart portal). the smart portal will use ibd-specific and general assessments and interventions to reduce the burden of common barriers to treatment adherence and enhance self-management skills. this study aims to build and revise the smart portal according to feedback and testing from participants.

the study consists of three phases for development and evaluation of the smart portal. phase 1 is the development of online assessments and intervention components. there will be no participant interaction with the portal during phase 1. phase 2 will consist of one, individual interview with patients, caregivers, and clinicians/nurses to interact with a portal prototype and provide feedback. phase 3 will contain an open trial for patients and caregivers with baseline, 2-6 months interacting with the portal and progressing through applicable intervention components, and post-treatment. patient test data will also be loaded into the portal during phase 3 for clinicians/nurses to interact with for 2-6 months. feedback from all users will be collected at post-treatment for optimization of the portal.

Eligibility criteria:
inclusion criteria: * patient diagnosed with crohn's disease, ulcerative colitis, or indeterminate colitis (collectively known as ibd) * patient between 11 and 18 years of age * patient prescribed at least one oral medication used to treat ibd * access to the internet whether public (example, library) or private (example, home, personal) * english fluency for patient, caregiver, and clinician/nurse * clinician/nurse currently providing medical treatment to patients diagnosed with ibd through the ibd center at cincinnati children's hospital medical center exclusion criteria: * diagnosis of pervasive developmental disorder in patient or caregiver * diagnosis of serious mental illness (example, schizophrenia) in patient or caregiver
conversational artificial intelligence (ai) to improve periconception care access

Conditions: Early Pregnancy Loss; Early Pregnancy

Summary: the goal of this project, conversational artificial intelligence (ai) to improve periconception care access (circa), is to engage patients in care early in pregnancy (before prenatal care starts) and safely triage concerns to peace to reduce unnecessary emergency department visits.


Eligibility criteria:
inclusion criteria: * pregnant * seeking to establish care at the hospital of the university of pennsylvania or seeking care in the emergency department or perinatal evaluation center.
ultrasonographic measurements of uterine junctional zone and association with in vitro fertilization treatment outcome

Conditions: Infertility, Female

Summary: the aim of this study is to prospectively examine the relationship of the uterine junctional zone thickness, evaluated by ultrasonography and in vitro fertilization (ivf) treatment outcome. the study hypothesis is that the uterine junctional zones of women who did not achieve pregnancy will be thicker than those of the women who do achieve pregnancy

ultrasounds of women who achieve pregnancy after ivf treatment will be compared to ultrasounds of women who do not achieve pregnancy. their uterine junctional zone thickness will be compared. the study hypothesis is that the uterine junctional zones of women who did not achieve pregnancy will be thicker than those of the women who do achieve pregnancy.

Eligibility criteria:
inclusion criteria: * undergoing ivf treatment due to male factor, polycystic ovary syndrome and unexplained infertility exclusion criteria: * low ovarian reserve * having undergone more than one d\&c
retinal, cerebral and vascular precursor markers of cerebral small vessel disease.

Conditions: Cerebral Small Vessel Diseases

Summary: cognitive impairment and dementia are primarily due to a combination of vascular brain injury and neurodegenerative lesions. the vascular component is now recognized as a major contributor to the pathophysiology of dementia, with small vessel disease (svd) being its most frequent substrate. this study aims to collect retinal microvascular markers as well as various parameters related to blood pressure and arterial stiffness, in a young adult population. the main objective is to explore the association between these parameters and structural changes on brain mri. results will allow to determine the most relevant biomarkers associated with very early brain imaging markers of svd.

small vessel disease is most often covert i.e detectable only on brain images without being associated with a clinical stroke. covert svd (csvd) is highly prevalent in older persons from the general population and is a powerful predictor of future cognitive decline and dementia risk. better detection of covert csvd, particularly at the earliest stages, would have a major impact on preventing disability and costs related to stroke, cognitive impairment and dementia. studying the association of retinal and vascular biomarkers with mri markers of brain structure will enable to facilitate the detection of patients at high risk of developing csvd and its complications. this study aims to collect ophthalmological (retinal image acquisition - part 1 of the study) and blood pressure / arterial stiffness (vascular assessment - part 2 of the study) markers from 400 young adults from the bordeaux bio-share study. in part 1, microvascular retinal biomarkers will be revealed by two complementary advanced technologies: the swept-source optical coherence tomography angiography (ss-oct-a) and the adaptative optics (ao). in part 2, participants will benefit from an in-depth vascular assessment.

Eligibility criteria:
inclusion criteria: young adults from the i-share cohort will be included in the study: * having signed the informed consent form of the mri-share sub-study, * having signed the informed consent form for the bio-share sub-study, * for whom brain mri images and for whom the results of the genome-wide genetic association study (gwas) are of good quality * having signed freely, an informed and written consent for this study (at the latest on the day of inclusion and before any examination required by the research), * being affiliated with social security. exclusion criteria: will not be included in the study: * participants with severe myopia greater than -6 dioptres * participants with known allergy to tropicamide (mydriaticum®)

Keywords: cognitive decline dementia stroke small vessel disease brain imaging adaptive optics optical coherence tomography angiography prevention risk prediction