Kornimate/medical-research-clean huggingface dataset:
coronary and cerebral perfusion optimization in cardiac arrest: a feasibility and physiological study

Conditions: Cardiac Arrest

Summary: our general objective, during this study, is to evaluate the feasibility and potential physiological benefits of using reboa (resuscitative endovascular balloon occlusion of the aorta) cpr (cardiopulmonary resuscitation) for patients presenting with a cardiac arrest to a community hospital. this would represent the first step for doing a larger, randomized clinical trial on the use of reboa in non-traumatic cardiac arrest.

primary objective: validate the feasibility of using reboa in a community hospital setting during cardiac arrest as an adjunct to acls (advances cardiac life support) . this will be done by measuring time to reboa placement and successful inflation. furthermore, we will also document any reboa related complications. secondary objectives: evaluate the potential physiological benefits of reboa for human subjects in ntca (non traumatic cardiac arrest) that are not responding to standard acls. study design and methodology trial design the trial is a single-center, single-arm, open (unblinded), feasibility, experimental study. study duration the study is expected to begin in winter 2022 and last approximately 12 months. population studied the population studied will be patients in non-traumatic cardiac arrest at santa cabrini hospital, aged 18-75 years old. patients presenting with a witnessed cardiac arrest (out of hospital cardiac arrest (ohca) or in hospital cardiac arrest (ihca)) and in which acls was performed for at least 15 minutes or bls for at least 30 minutes and for no more than 60 minutes will be evaluated for eligibility to participate in the study. number of patients 20

Eligibility criteria:
inclusion criteria: * - patients aged 18-75 years old * suspected reversible cause of cardiac arrest (except for trauma), with one of any of the following prognostic signs30 * reactive pupils * agonal breathing * etco2\>10 mmhg * any cardiac activity on bedside echocardiogram * body habitus accommodating automated lund university cardiac arrest system (lucas) * level of care includes cpr, or unable to obtain level of care (if possible, validate with relative) * more than 15 minutes of acls with no rosc or more than 30 minutes of bls with no rosc exclusion criteria: * transfer accepted for ecpr * history of severe dementia * advance medical directives against resuscitation * history of aortic pathology or surgery * lucas not compatible with the patient's body habitus * pregnancy * any illness resulting in loss of independent living capacity * severe cardiopulmonary disease * aortic dissection, aortic aneurysm, tension pneumothorax or tamponade seen on tee/tte * strangulation * suspected intracerebral hemorrhage * accidental hypothermia * more than 60 minutes of resuscitation

Keywords: reboa rosc cardiac arrest
comparative study of valsartan and amlodipine versus amlodipine alone in hypertension

Conditions: Hypertension

Summary: the objective of this study is to evaluate efficacy, safety and tolerability of the valsartan+amlodipine association in patients with mild to moderate essential hypertension, in comparison to amlodipine alone. patients should have mild to moderate essential hypertension \[grades 1 and 2 of who classification (8)\]. the diastolic blood pressure threshold for inclusion in this study is 95 mmhg, as these patients are more likely to benefit from association therapy than patients with lower diastolic blood pressure. for safety reasons, patients with severe hypertension (grade 3 of who classification) will not be included in this study. moreover, patients developing severe hypertension (msdbp \> 110 mmhg and/or mssbp \> 180 mmhg) during the open-label treatment phase will be discontinued from the study.


Eligibility criteria:
incl- patients with mild to moderate essential hypertension (grade 1 and 2 of who classification). - patients with essential diastolic hypertension measured by a standard aneroid or mercury column sphygmomanometer showing msdbp \> 95 mmhg and \< 110 mmhg and mssbp \<180 mmhg. exclusion criteria: * severe hypertension (grade 3 of who classification: dbp \>= 110 mmhg and/or sbp ≥ 180 mmhg) or malignant hypertension. * inability to completely discontinue all antihypertensive medications safely for a period of at least 2 weeks as required by the protocol. * evidence of a secondary form of hypertension, such as coarctation of aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, cushing's disease, pheochromocytoma, polycystic kidney disease, etc.

Keywords: valsartan amlodipine hypertension
glucose metabolism and sleep in people with family history of type 2 diabetes.

Conditions: Sleep; Insulin Resistance; Type 2 Diabetes

Summary: the use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. however, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). this study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

on two consecutive inpatient days, the participants in this study will undergo two different tests. the first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. the second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Eligibility criteria:
inclusion criteria: * regular sleep habits * bmi 20 to 27 kg/m2 * at least one parent, sibling or grandparent with type 2 diabetes * no regular exercise habits exclusion criteria: * active smoker * night or shift work * have highly variable sleep habits * have a hormonal disorder * have a sleep disorder * have an active medical problem * women only: use of birth control pills * women only: irregular menstrual periods or pregnancy * use of medications/compounds that can disrupt sleep

Keywords: short sleep duration glucose clamp technique insulin secretion insulin action lipid turnover free fatty acids
validation of a shared decision-making tool for multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study evaluates a novel shared decision making tool for multiple sclerosis (ms). half the patients will be given access to ms-support before their scheduled appointment with their healthcare provider, the other half will not be given access.

ms-support is a novel shared-decision making tool. more specifically, it is a web-based decision aid (da) that includes 'values clarification exercises' to support people with ms (pwms) incorporate their preferences and values when faced with a dmt treatment decision. each 'values clarification exercise' includes a written passage about a specific topic, with a series of questions. it covers topical domains related to living with ms and treatment decision making, including but not limited to lifestyle, tolerability, safety, risk tolerance, health goals, and personal values. this validation study will evaluate the effect of using ms-support on starting or switching dmts, patient-provider communication, dmt adherence, quality of life (qol), decision quality (the concordance of the treatment chosen, which includes no treatment, with the patient's values), quality of care, and decisional conflict. participants will include adult patients with relapsing forms of ms and their ms healthcare providers (hcp). patients will be randomized into one of two groups: ms-support (intervention) or usual care (control).

Eligibility criteria:
for ms patients: inclusion criteria: * able to read and write in english * live within the united states and receive ms care in the usa * 18 years or older * having a diagnosis of a relapsing form of ms, including relapsing remitting multiple sclerosis (rrms), active secondary progressive ms, and clinically isolated syndrome (cis) * having access to the internet * having a valid email address * have a healthcare provider who is managing their ms * having an upcoming appointment with an ms healthcare provider to manage their ms within the next 12 weeks exclusion criteria: • unable or unwilling to give informed consent for hcps: inclusion criteria: * english-speaking * any hcp who manages a participating patient's ms exclusion criteria: • unable or unwilling to give informed consent
omega-3 fatty acids for prevention of post-operative atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this is a large multi-center study to examine whether peri-operative intake of n-3 polyunsaturated fatty acids (pufa) will reduce the occurrence of post-operative atrial fibrillation or flutter (af) in patients undergoing cardiac surgery (cs).


Eligibility criteria:
inclusion criteria: * age 18 years or over * scheduled for cs on the following day or later, including coronary artery bypass, valve surgery, any other open cardiac surgery (i.e., that includes opening of the pericardium), or any combination. * sinus rhythm on current ecg (sinus bradycardia, sinus tachycardia, and ectopy are acceptable). exclusion criteria: * regular use (3 or more days/week) of fish oil within the past 4 weeks. * known allergy or intolerance to fish oil or corn oil. * currently pregnant. * unable to provide informed written consent. * current or planned cardiac transplant or lvad

Keywords: atrial fibrillation fish oil
integrative ayurveda healing relieves minor sports injury pain

Conditions: Acute Pain; Sports Injury

Summary: sports-related soft tissue injuries, such as sprains, strains, and contusions, are a common painful condition. current treatment includes oral nonsteroidal anti-inflammatory drugs (nsaids), which have a high incidence of intolerable gastrointestinal side effects. ancient indian healing system, ayurveda addresses the need of sports medicine up to certain extent. in practice, there are different treatment modalities for injuries, uses of drugs \& dietetics as well as practices of rehabilitation. although, previous evidences support the efficacy of ayurveda practices with significant reduction in pain, joint tenderness, joint swelling, mobility restriction and early morning joint stiffness. but there is no treatment studies have been performed to evaluate the clinical outcome for specific sports injuries. this study assessed the efficacy and safety of ayurveda gel and patches applied to the painful injury site for the treatment of acute minor sports injury pain.


Eligibility criteria:
inclusion criteria: * inversion ankle injury; * injury sustained during sporting activity exclusion criteria: * other lower limb injury; * concurrent fracture with or without dislocation or with or without complete rupture; * surgery for ankle injury.

Keywords: ayurveda acute pain sports injury
potential research study participant registry

Conditions: Acne; Actinic Keratosis; Dysplastic Nevi; Eczema; Psoriasis; Skin Cancer; Rosacea; Leg Ulcers; Foot Ulcers; Atopic Dermatitis

Summary: the purpose of the potential research study participant registry is to keep potential research subjects informed about any future research studies in which they may meet the criteria for enrollment. the purpose of this study is also to assist current and future clinical trials with recruitment of subjects.

methods: subjects will self identify themselves via the ucdmc dermatology website to complete a survey regarding their interest in learning about future dermatology clinical research projects. subjects provide contact information and check of a list of potential topics of interest. procedures: potential participants will find a link on the ucdmc dermatology website to our registry. the potential participant will read information about the registry. if they wish additional information, they can follow a link to the potential research registry consent form. at this stage, the potential participant may answer, "no" to the consent form and they will be redirected back to the clinical trials website. if they answer, "yes" then they will be linked to the registry questionnaire. the potential subject would then decide if they want to participate in the registry and if so what information they want to provide. the clinical research coordinators would contact potential study participants to see if they meet the eligibility criteria for any of our current studies.

Eligibility criteria:
inclusion criteria: * over 18 years of age exclusion criteria: * under 18 years of age

Keywords: acne actinic keratosis dysplastic nevi eczema psoriasis vitiligo skin cancer rosacea leg or foot ulcers atopic dermatosis
a phase i study of zd1839 and palliative thoracic radiotherapy in patients with non-small-cell lung cancer

Conditions: Non-small-cell Lung Cancer

Summary: the purpose of this study is to characterize the safety profile of zd1839 in combination with palliative thoracic radiotherapy in patients with non-small cell lung cancer


Eligibility criteria:
inclusion criteria: * provision of written informed consent * patients requiring low dose palliative thoracic irradiation to a field size of less than or equal to 150cm2 * histologically or cytologically conformed non-small cell lung cancer * aged 18 or over exclusion criteria: * previous thoracic radiotherapy * any condition that may pre-dispose the patient to suffer an individual drug-relaged dlt (dose limiting toxicity) event * known hypersensitivity to any component of study medication
measurement of cerebral oxygenation using nirs method in the preterm infants with intracranial haemorrhagia

Conditions: Cerebral Oxygenation, Intracranial Haemorrhagia

Summary: the aim of the study was investigated the cerebral tissue oxygenation index (c-toi) measured by near infrared spectroscopy (nirs)in the preterm infants with intracranial haemorrhagia.


Eligibility criteria:
inclusion criteria: .\<34 gestation week preterm infants with intracranial haemorrhagia exclusion criteria: * sepsis * nec * congenital abnormalities * hydrocephalus * intracranial infections

Keywords: preterm infant,cerebral oxygenation, intracranial haemorrhagia
effect of inorganic nitrate supplement on blood pressure

Conditions: Blood Pressure; Endothelial Dysfunction

Summary: the primary purpose of this project is to assess the efficacy (effectiveness) of plant-based nitrate tablets to elevate nitric oxide in your system as measured by saliva and effect on lowering blood pressure (bp), supporting blood vessel function in men and women with hypertension.

this clinical trial is to assess the efficacy of plant-based bioequivalent nitric oxide supplement for improving blood pressure and endothelial reactivity over a 12 weeks intervention period in individuals with metabolic syndrome. the study also examines the effect of plant-based bioequivalent nitric oxide supplement on other markers of cardiovascular function and cardiovascular disease risk including total, ldl and hdl-cholesterol, triglycerides, and a multitude of inflammatory markers.

Eligibility criteria:
inclusion criteria: * age 40-75 years * hypertension \>130/85 mmhg; men and women, 1:1 and stable medicated hypertensives * subjects must provide written informed consent after the scope and nature of the investigation has been explained to them exclusion criteria: * any unstable medical, psychiatric or substance abuse disorder that in the opinion of the investigator or principal investigator is likely to affect the subject's ability to complete the study or precludes the subject's participation in the study * weight in excess of 250 pounds * bleeding disorder * history of known coronary artery disease, myocardial infarction, stroke or life-threatening arrhythmia within the prior six months * nyha class ii- iv heart failure * history of malignancy within the last 5 years (other than skin cancer) or evidence of active cancer which would require concomitant cancer chemotherapy * serum creatinine \> 1.4 mg/dl * triglycerides \> 400 at visit 1 * drug or alcohol abuse, or current intake of more than 14 standard drinks per week * concurrent enrollment in another placebo-controlled trial * partial ileal bypass or known gastrointestinal disease limiting drug absorption * current tobacco use * current use of anticoagulants (except for anti-platelet agents) * renal failure * history of hypertensive encephalopathy or cerebrovascular accident * hematological or biochemical values at screening outside the reference ranges considered as clinically significant in the opinion of the investigator or pi * pregnancy

Keywords: endothelium
optimizing the effect of copd rehabilitation

Conditions: Chronic Obstructive Pulmonary Disease

Summary: patients with chronic obstructive pulmonary disease (copd) may benefit from an 8-week pulmonary rehabilitation programme. however, the effect of the programme tends to attenuate with time. patients who complete the programme are randomized to continued rehabilitation follow-up and control follow-up.

patients with chronic obstructive pulmonary disease (copd) may benefit from an 8-week pulmonary rehabilitation programme according to guidelines of the danish society of pulmonary medicine. however, the effect of programme tends to attenuate with time. patients who complete the programme are randomized to continued rehabilitation follow-up and control follow-up.

Eligibility criteria:
inclusion criteria: * fev1 \< 60% of expected exclusion criteria: * other severe chronic conditions

Keywords: copd, rehabilitation, quality of life
towards better preparedness for future catastrophes - local lessons-learned from covid-19

Conditions: COVID-19 Pandemic; Emergencies

Summary: the research question of this study is: "what lessons have been learned from the civil-military cooperation in heidelberg, germany, during the covid-19 pandemic, and what needs to be done to be better prepared for future disasters?" it is expected that the results of this research provide a deep expert insight into covid-19 disaster preparedness at the local level. flanked by comparison with published experiences at the global level, these lessons-learned would contribute to strengthening local crisis resilience sustainably in the future.

design, execution, analysis and publication of this study is conducted in compliance with the international quality criteria "strengthening the reporting of observational studies in epidemiology (strobe)" and "standards for reporting qualitative research (srqr)". this is a monocentric, qualitative, mixed-methods, non-interventional, non-randomized research project.

Eligibility criteria:
inclusion criteria: 1. age over 18 years 2. direct or indirect involvement in civil-military collaboration during the covid-19 crisis 3. ability to provide consent 4. providing written informed consent to participate in the study exclusion criteria: 1) failure to provide written informed consent to participate in the study

Keywords: covid-19 disaster management preparedness lessons-learned resilience
stereotactic radiosurgery prognosis assessment for spinal tumors based on radiomics

Conditions: Stereotactic Radiosurgery; Spinal Tumor; Radiomics; Prognosis

Summary: this study aims to assess multimodal radiomics-based prediction model for prognostic prediction in spinal tumors.

sensitivity for prediction recurrence and survival of currently available prognostic scores is limited. this study proposes to establish a multimodal radiomics model for identifying tumor recurrence and prognostic prediction of spinal tumors. the study will investigate the relationship between the radiomics and the tumor microenvironment. the study includes the construction of multimodal radiomics-based prediction model and the validation of the prediction model.

Eligibility criteria:
inclusion criteria: a diagnosis of spinal tumors for which sbrt is appropriate karnofsky performance status \>60 life expectancy of at least 3 months no contraindication to undergoing mr imaging age \>18 complete the ct mri or pet-ct examination before and after treatment accept stereotactic radiosurgery exclusion criteria: subjects unable to undergo mri (includes non-mri compatible material or devices and severe claustrophobia) subjects with prior procedural intervention to the involved vertebral body that would result in artifact (kyphoplasty, screw and/or rod placement); minimally invasive surgery without instrumentation of the involved vertebral body and instrumentation immediately above or below the index lesion is allowed. subjects with spinal cord compression; minimally invasive "separation" surgery to first resect the epidural component is allowed pregnant or breast-feeding women allergy to standard iv contrast agents used in mri
correlation between serum adiponectin and resistin levels and degree of hepatic fibrosis in masld with type2 diabetes mellitus

Conditions: Hepatic Fibrosis

Summary: metabolic dysfunction asociated steatotic liver disease prevalence is 25%world wide diabetic patients have a risk for masld then have hepatic fibrosis so we study correlation between serum adiponectin and resistin levels and degree of hepatic fibrosis in metabolic dysfunction asociated steatotic liver disease in patients with type2 diabetes mellitus


Eligibility criteria:
inclusion criteria: * patients of both sex who have type2 diabetes mellitus for less than five years exclusion criteria:alcholics ,chronic liver disease elevated liver functions , sever infection -
recombinant fusion protein linking coagulation factor ix with albumin (rix-fp) in chinese subjects with hemophilia b previously treated with fix therapy

Conditions: Hemophilia B

Summary: this study will investigate the pharmacokinetics (pk), efficacy, and safety of rix-fp for the routine prophylaxis of bleeding episodes in male chinese previously treated patients (ptps) with hemophilia b (fix activity of ≤ 2%). in addition to the scheduled rix-fp prophylaxis regimen, subjects may also receive rix-fp episodic (on-demand) treatment for breakthrough bleeding episodes and rix-fp for the prophylaxis and treatment of bleeding in emergency surgical procedures.


Eligibility criteria:
inclusion criteria: * male chinese subjects aged ≤ 70 years * subjects with documented severe or moderately severe hemophilia b (fix activity of ≤ 2%) * subjects have received fix products for ≥ 150 exposure days (eds) (subjects aged ≥ 6 years) or ≥ 50 eds (subjects aged \< 6 years) * subjects have no confirmed prior history of fix inhibitor formation exclusion criteria: * known hypersensitivity (allergic reaction or anaphylaxis) to any fix product or hamster protein. * known congenital or acquired coagulation disorder other than congenital fix deficiency. * currently receiving intravenous (iv) immunomodulating agents such as immunoglobulin or chronic systemic corticosteroid treatment. * currently receiving a long-acting recombinant fix treatment such as coagulation factor ix (recombinant), fc fusion protein (alprolix®). * use of traditional or herbal chinese medicine(s) with an impact on hemophilia, including coagulation, within 28 days before day 1 and / or refusal to abstain from these during the study until the end of the subject's participation in the study.