Kornimate/medical-research-clean huggingface dataset:
efficacy of scalp block and ultrasound guided tap block with clonidine as adjuvant to ropivacaine versus intravenous fentanyl on intraoperative hemodynamics and perioperative analgesia in abdominal bone flap cranioplasties

Conditions: Condition: Abdominal Bone Flap Cranioplasty; Focus of Study: Perioperative Analgesia

Summary: this study assesses efficacy of scalp block and ultrasound guided transverse abdominis plane (tap) block with 1µg/kg clonidine as adjuvant to 0.2% ropivacaine versus intravenous fentanyl (0.1µg/kg/hr) on intraoperative hemodynamics and perioperative analgesia in abdominal bone flap cranioplasties (abfc).

scalp blocks with local anaesthetic agents along with general anaesthesia provides intraoperative and postoperative analgesia by blunting the hemodynamic responses to noxious stimuli. the transversus abdominis plane "tap" block, a regional anaesthesia technique that provides analgesia following abdominal surgery. it involves a single large bolus injection of local anaesthetic into an anatomical space between the internal oblique and transversus abdominis muscles. ropivacaine is less cardio toxic, less arrhythmogenic, less toxic to central nervous system (cns) than bupivacaine, and it also has intrinsic vasoconstrictor property. clonidine is an alpha-2 receptor agonist, which has a known property of reducing requirement of analgesics in the perioperative period. this study aimed to assess the efficacy of scalp block and tap block with 1µg/kg clonidine as adjuvant to 0.2% ropivacaine versus intravenous fentanyl (0.1µg/kg/hr) on intraoperative hemodynamics and perioperative analgesia in abdominal bone flap cranioplasties.

Eligibility criteria:
inclusion criteria: patients undergoing abdominal bone flap replacement. exclusion criteria: 1. motor and comprehensive aphasia, 2. disoriented mental state or inability to follow commands. 3. hypersensitivity to amide local anesthetics, 4. bone flap site infection 5. coagulation disorders

Keywords: scalp block transversus abdominis plane block ropivacaine clonidine
laser - a new possibility in fertility treatment - a pilot study

Conditions: Infertility; Exposure Laser

Summary: in this study the investigators want to investigate if the pregnancy rate in conjunction with fertility treatment increases with concomitant use of laser therapy.

furthermore the investigators want to examine the participants general mental and physical wellbeing during the experimental period using a vas-scale.

Eligibility criteria:
inclusion criteria: 1. bmi : 18-32 2. long agonist/short antagonist ivf/intracytoplasmatic sperm injection (icsi)treatment 3. 1-2 ivf/icsi treatments without obtaining pregnancy. 4. signed consent exclusion criteria: 1. uterine malformations 2. uterine fibroids/polyps 3. need of an interpreter. 4. d.m, epilepsy, liver-kidney-heart disease 5. endometrial biopsy 6. cancer former cancer disease 7. acupuncture 8. metal in the body 9. suspicious naevi and tatoo´s
a study of krn125 in patients with multiple myeloma and malignant lymphoma

Conditions: Multiple Myeloma and Malignant Lymphoma

Summary: to determine if krn125 is non-inferior to filgrastim for the mobilization of hematopoietic stem cells into the peripheral blood in patients with multiple myeloma.


Eligibility criteria:
inclusion criteria: criteria for the multiple myeloma cohort * patients with histologically or pathologically diagnosed multiple myeloma * patients who achieved cr, scr, vgpr, and pr with induction therapy criteria for the malignant lymphoma cohort * patients with histologically or pathologically diagnosed malignant lymphoma * first or second cr or pr multiple myeloma cohort, malignant lymphoma cohort common criteria * patients aged 20 to 75 years or younger at the time of informed consent exclusion criteria: * those who received allogeneic hematopoietic stem cell transplantation (allo-sct), autologous hematopoietic stem cell transplantation (asct), or car-t therapy * patients who have developed adverse events leading to discontinuation of hematopoietic stem-cell collection due to administration of granulocyte colony-stimulating factor (g-csf) or apheresis * patients who have not been able to collect adequate amounts of hematopoietic stem cells with g-csf or plerixafor administration * patients with hypersensitivity to g-csf or plerixafor * patients with ecog performance status (pss) of 2 or greater. * patients whose cardiac or pulmonary conditions were judged to be inappropriate for apheresis or asct. * pregnant or breastfeeding female patients
mid-term follow-up for tailored atvm

Conditions: Lower Urinary Tract Symptoms

Summary: lower urinary tract symptoms may change after pelvic organ prolapse surgery. thus, the aim of this study was to elucidate (1) the changes of lower urinary tract symptoms and (2) the changes in values of urodynamic parameters between baseline and after pelvic organ prolapse surgery.

between november 2011 and december 2015, medical records of all consecutive women who underwent anterior transvaginal mesh surgery (atvm) but without concomitant mid-urethral sling surgery were reviewed. data of pre- and post-operative lower urinary tract symptoms and urodynamic parameters were compared. the bladder outlet obstruction was defined when the detrusor pressure at maximum flow rate was not less than 40cmh2o, and the maximum flow rate was less than 12 ml/s. overactive bladder syndrome, detrusor overactivity, bladder oversensitivity and urodynamic stress incontinence were also recognized as international continence society definition. stata software was used for statistical analysis. wilcoxon signed-rank test or mcnemar's test was used for statistical analysis as appropriate. p \< 0.05 was considered as statistically significant.

Eligibility criteria:
inclusion criteria: * women with pelvic organ prolapse * women received anterior transvaginal mesh surgery exclusion criteria: * concomitant mid-urethral sling surgery * chronic urinary tract infection * interstitial cystitis * malignancy history in pelvic organ * ever received pelvic radiation * concomitant transabdominal surgery

Keywords: pelvic organ prolapse transvaginal mesh lower urinary tract symptoms urodynamic study
fluorouracil and leucovorin and/or levamisole after surgery in treating patients with dukes' b or dukes' c colon cancer

Conditions: Colorectal Cancer

Summary: rationale: drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. leucovorin may help fluorouracil kill more tumor cells. biological therapies, such as levamisole, may interfere with the growth of tumor cells and slow the growth of solid tumors. it is not yet known whether fluorouracil is more effective when given together with leucovorin and/or levamisole after surgery in treating colon cancer. purpose: this randomized phase iii trial is studying giving fluorouracil together with leucovorin to see how well it works compared with giving fluorouracil together with levamisole, or giving fluorouracil together with leucovorin and levamisole after surgery in treating patients with dukes' b or dukes' c colon cancer.

objectives: i. compare, in a phase iii setting, disease-free survival and overall survival of patients who have undergone potentially curative resection of dukes' b or c carcinoma of the colon randomly assigned to adjuvant therapy with 5-fluorouracil/leucovorin vs. 5-fluorouracil/levamisole vs. 5-fluorouracil/leucovorin/levamisole. outline: randomized study. arm i: single-agent chemotherapy with drug modulation. 5-fluorouracil, 5-fu, nsc-19893; with leucovorin calcium, citrovorum factor, cf, nsc-3590. arm ii: single-agent chemotherapy with drug modulation plus biological response modifier therapy. 5-fu; with cf; plus levamisole, lev, nsc-177023. arm iii: single-agent chemotherapy plus biological response modifier therapy. 5-fu; plus lev. projected accrual: 1,800 evaluable patients will be accrued over about 3 years; an additional 2 years will be required before final analysis.

Eligibility criteria:
disease characteristics: see general eligibility criteria patient characteristics: see general eligibility criteria

Keywords: stage ii colon cancer stage iii colon cancer
naltrexone treatment of alcohol dependence

Conditions: Alcoholism

Summary: the long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support. this proposal has three specific aims: (1) to compare the effectiveness of naltrexone (revia) in three types of treatment settings; (2) to assess the effects of psychosocial support on medication compliance and treatment retention; and (3) to investigate the individual characteristics that may predict who is likely to benefit from additional psychosocial support versus simple medication management.


Eligibility criteria:
inclusion criteria: * meets criteria for current diagnosis of alcohol dependence. * subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day of 5 or more drinks in the past 30 days. * successful completion of medical detoxification. * lives within a commutable distance to the treatment research center and agrees to follow-up visits. * understands and signs the informed consent. exclusion criteria: * current diagnosis of any substance dependence other than alcohol, nicotine, or marijuana. * evidence of opiate use in the past 30 days. * current treatment with psychotropic medications, including disulfiram (antabuse) (excluding short-term use of benzodiazepines for detoxification). * history of unstable or serious medical illness, including need for opioid analgesics. * severe physical or medical illnesses such as aids, active hepatitis, significant hepatocellular injury as evidenced by elevated bilirubin levels, and current severe psychiatric symptoms. * use of an investigation medication in the past 30 days. * female subjects who are pregnant, nursing, or not using reliable method of contraception.
home-based exercise training for lung cancer patients awaiting surgery

Conditions: Lung Neoplasm

Summary: surgical resection is the only curative treatment in patients diagnosed with lung cancer, the most mortal type of malignancy globally. however, following lung cancer resection, patients experience a substantial deterioration in health-related quality of life and have an increased risk of developing pulmonary complications. although current clinical guidelines strongly recommend preoperative exercise training to improve clinical outcomes after lung cancer surgery, inaccessibility to facility-based exercise programs is a major barrier to routine participation, with patients indicating a strong preference to exercise in a home-based environment. the primary purpose of the present study was to evaluate the feasibility of a home-based exercise program (hbep) in lung cancer patients awaiting surgical treatment. the secondary purposes were to evaluate the safety of the hbep and to explore exercise effects on patients' hrqol and physical performance, either pre-and post-surgery.


Eligibility criteria:
inclusion criteria: * scheduled for surgical treatment of suspected or confirmed lung cancer (clinical stage iiia or less) * waiting time for surgery of at least two weeks from baseline assessment * medical clearance to exercise. * signed informed consent prior to initiation of study-related procedures. exclusion criteria: * metastatic cancer * presence of physical or mental disabilities that contraindicated exercise training or physical testing * unable to communicate in portuguese or english * performing combined aerobic plus resistance training over the past month (self-reported ≥2 days a week, ≥30 minutes each session).
the effect and mechanism of wcst-ll based precision rehabilitation nursing on motor dysfunction after acute stroke

Conditions: Acute Ischemic Stroke

Summary: ischemic stroke is the main cause of disability in the world. more than 70% of stroke patients show various degrees of neural function impairment. motor rehabilitation in acute phase is beneficial for improving patient's structure and function of corticospinal tract. however, it is difficult to obtain effective rehabilitation during the acute phase of stroke because of the insufficiency of professional rehabilitation therapists in stroke wards in china.the present study is to verify that nursing-directed rehabilitation can compensate for the shortage of professional rehabilitation therapists. our previous study indicated that nursing-directed motor function rehabilitation provided more obvious effect on stroke patients with a weighted corticospinal tract lesion load (wcst-ll) smaller than 2ml. we assume that implementing rehabilitation nursing based on the wcst-ll can realize nursing-directed, wcst-ll-based precision motor rehabilitation during acute phase of ischemic stroke.the present study is to conduct randomized clinical trial to confirm the effect of nursing-directed precision rehabilitation for motor function in acute stroke patients grouped by wcst-ll, and to evaluate the effect of this precision rehabilitation by using functional scale, and to explore the histopathologic mechanism of the precision rehabilitation nursing by mean of neuroelectrophysiology and neuroimaging examination. this study might provide theoretical support for motor rehabilitation in patients during acute phase of stroke.


Eligibility criteria:
inclusion criteria: * the patients were diagnosed as ischemic stroke by ct or mri and met the diagnostic criteria of world health organization(who); * first stroke, within 7 days, with limb dysfunction (muscle strength \< 5 grade); * there was no contraindication sign of mri and transcranial magnetic stimulation(tms) examination, and the examination was completed with good image quality and complete clinical data; * 18≤ages≤90; * consciousness exclusion criteria: * the blood vessels are reconnected after thrombolysis; * there are serious cardiopulmonary dysfunction, history of craniocerebral trauma, and other diseases affecting the affected side
psychophysiological effects of thorax wraps with ginger and mustard flour

Conditions: Healthy

Summary: in integrative medicine wraps are applied for different indications. in this study the effects of thorax with ginger and mustard flour are investigated under standardized conditions. heart rate variability, well being, warmth distribution and respiratory activity of healthy subjects will be measured.

the purpose of this study is to investigate the effects of different thorax wraps in healthy subjects. subjects undergo three different interventions (wraps with ginger flour, mustard flour or warm water (placebo)) on three different days. heart rate variability and respiratory activity is measured for ten minutes before, during (up to 20 minutes) and for ten minutes after each thorax wrap. to investigate the effects on heat development and regulation, photos are taken with a thermographic infrared camera at various moments in time. participants are asked to fill in questionnaires referring to their subjective perceptions of warmth, bodily warmth distribution and wellbeing. the order of the thorax wrap interventions is randomized.

Eligibility criteria:
inclusion criteria: * signed informed consent. exclusion criteria: inflectional disease with body temperature \> 38 °c. skin damage on the thorax area known intolerance or hypersensitivity to mustard or ginger products. heart failure. asthma bronchiale. taking medication with influence on heart rate variability ( mainly tricyclic antidepressants and beta blocker). consumption of coffee or nicotine less than three hours before the intervention. pregnancy. deficient knowledge of the german language.

Keywords: physiologcal phenomena .hrv parameters respiratory activity thorax wraps
oral versus intravenous antibiotic prophylaxis before obstetric and gynecological procedures

Conditions: Site Infection

Summary: oral versus intravenous antimicrobial prophylaxis for the prevention of surgical site infection for elective cesarean section and gynacological procedures

the aim of the current study is to compare the efficacy of prophylactic intravenous (cephradine) and oral antibiotic (cephradine) for the prevention of surgical site infection in the elective obctetric and gynecological procedures

Eligibility criteria:
inclusion criteria: - cesarean section gynaecological procedure exclusion criteria immunocompromised patient -

Keywords: ssi
transfusion-related inflammatory cytokine and neutrophil extracellular trap quantification in neonates

Conditions: Anemia of Prematurity; Necrotizing Enterocolitis

Summary: despite many advances in neonatal care, necrotizing enterocolitis (nec) remains a leading cause of morbidity and mortality among premature infants. nec is the most common life-threatening gastrointestinal emergency encountered in the neonatal intensive care unit, affecting between 3.8% and 13% of very low birthweight (vlbw) infants (1-3). more recently interest has intensified regarding the possible association between "elective" red blood cell (rbc) transfusions in premature infants and the subsequent development of nec (4-9). on a physiological basis, a few explanations for transfusion-associated nec have been proposed: 1) the physiological impact of anemia that can initiate a cascade of events leading to ischemic-hypoxemic mucosal gut injury predisposing to nec \[10\]; and 2) increased splanchnic blood flow following rbc transfusion leading to reperfusion injury of gut mucosa. aim 1. this study will quantify inflammatory cytokine profiles in anemic infants cared for in the nicu prior to and after transfusion with packed red blood cells (prbc), as dictated by current clinical guidelines for treatment of anemia, and prospectively assess for clinical signs and symptoms of nec following each transfusion event. aim 2. polymorphonuclear leukocytes (pmns) isolated from the pre- and post-transfusion blood samples will be assessed in vitro for neutrophil extracellular traps (net) formation. aim 3. a) to determine whether significant anemia preceding a rbc transfusion is associated with impaired intestinal oxygenation, and whether a rbc transfusion temporarily increases splanchnic oxygenation. we postulate that the csor will be low (\<0.75) at baseline measurement in infants with hemodynamically significant anemia, and that rbc transfusion will temporarily increase intestinal perfusion in that particular group of babies. b) to determine whether alterations in mesenteric regional oxygenation saturation(rso2) can predict the development of nec in vlbw infants. we hypothesize that overall cerebro-splanchnic oxygenation ratio (csor) values will be significantly lower among very low birth weight (vlbw) infants that develop nec, when compared to csor values obtained in infants that do not develop nec following rbc transfusion.


Eligibility criteria:
inclusion criteria: * inpatient in nicu at uumc, pcmc, or imc * gestational age at birth ≤ 32 weeks * birth weight ≤ 1500 grams * age ≤ 12 weeks of life exclusion criteria: * lack of parental consent * multiple congenital anomalies

Keywords: gut reperfusion injury blood transfusions premature infants anemia regional oxygen saturations necrotizing enterocolitis mesenteric oxygenation
motivational behavioral and functional mri impairment in patients with chronic neuropathic pain

Conditions: Chronic Pain

Summary: the main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. the fmri studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.


Eligibility criteria:
inclusion criteria: * for cases: patients managed in the neurosurgery department or at cetd for chronic neuropathic pain, of central or peripheral origin. * for controls: matched to a case on age (±5 years) and sex exclusion criteria: * neurodegenerative or inflammatory neurological pathology * clinical depressive syndrome * high doses of opioid treatment (greater than 100 mg/day of morphine equivalent) * impaired judgment or inability to receive information that does not allow the performance of behavioral tasks * absolute contraindication to mri (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
a prospective study to evaluate the consistency of next-generation sequencing(ngs)-panels by using malignant hydrothorax form nsclc

Conditions: Malignant Hydrothorax; NSCLC

Summary: a prospective study to evaluate consistency of different ngs-panel. cell free dna is purified from each malignant hydrothorax from nsclc .different ngs-panels are applied to perform in vitro diagnosis to detect single nucleotide variants(snv) and to calculate tmb value in these dna samples.consistency of enrolled ngs-panels are then evaluated by statistical analysis.

1. chest hospital in accordance with the clinical requirements of the treatment required to extract ml hydrothorax sent to hospital pathology department for exfoliated cell diagnosis and production of cell wax block, while the additional responsibility for the extraction of hydrothorax 500ml, and collect 10ml venous blood sample, venous blood samples are stored in either the a cell-free dna blood collection tube (streck tube) or the ethylenediaminetetraacetic acid(edta) anticoagulant tube. 2. amoy diagnostics co., ltd. (amoydx) is responsible for plasma separation after sampling 2 hours, plasma is frozen by the chest hospital, amoydx completes the purification of peripheral blood cells genomic dna , and which is divided into 6 parts ,5 of which are send to in vitro diagnostic products (ivd) enterprises to perform ngs-panel detection. 3. 100ml hydrothorax is send to each ivd enterprise. 4. each ivd enterprise carries on the hydrothorax cell free dna and peripheral blood cell genomic dna ngs-panel detection according to their own protocol. 5. each ivd enterprise will complete the test within 7-10 working days and fill out the results in accordance with the report template provided by this research project (provided by guangzhou burning rock medical examination institute co., ltd.) and submit to sponsor by email. 6. sponsor would use whole exon panel (wes) to obtain an tmb value if needed. 7. employ four-grid analysis to evaluate positive compliance rate, negative compliance rate, total compliance rate of all submitted data. 8. employ kappa test to evaluate the consistency of each two detections.

Eligibility criteria:
inclusion criteria: * advanced malignant lung cancer, with treatment of pleural effusion, hydrothorax volume not less than 800ml exclusion criteria: * the sample size is not sufficient to detect. * there are not enough tumor cells in the tissue section to be evaluated through the pathology department of the chest hospital.

Keywords: nsclc malignant hydrothorax prospective study