Kornimate/medical-research-clean huggingface dataset:
use of alternative therapy in acne vulgaris patients

Conditions: Acne Vulgaris

Summary: acne vulgaris is a chronic skin disease. however, chronic and repetitive due to the quality of life and psychological status of patients can affect. today, although the treatment is repetitive, chronic and requires follow-up due to the disease patients can turn to alternative and complementary medicine techniques. in recent years, studies on alternative medicine and complementary therapies have been noted in the medical literature. these studies also include case reports related to acne vulgaris. however, in our country, there is no study that tells us whether patients with acne vulgaris apply these treatments or not and what the practitioners think about the success of the treatment. the aim of the study will be to clarify issues such as whether patients with acne vulgaris apply alternative medicine and complementary therapies for their disease.


Eligibility criteria:
inclusion criteria: * acne vulgaris patients between age 12-60 exclusion criteria: * the ones who don't want to answer the questions
real-time activity monitoring to prevent admissions during radiotherapy

Conditions: Cancer of the Head and Neck; Cancer of Lung; Cancer of Esophagus; Cancer of Stomach

Summary: this study will aim to demonstrate that implementation of a rapid, multidisciplinary supportive care program for patients receiving chemoradiotherapy who are deemed to be at high risk for hospitalization based on real-time pedometer data will reduce the rate of hospitalization during chemoradiotherapy or within four weeks of radiotherapy completion.

primary objective * to demonstrate that implementation of a rapid, multidisciplinary supportive care program for patients receiving chemoradiotherapy who are deemed to be at high risk for hospitalization based on real-time pedometer data will reduce the rate of hospitalization during chemoradiotherapy or within four weeks of radiotherapy completion. secondary objectives * to demonstrate the feasibility of a program of rapid, multidisciplinary supportive care triggered by real-time pedometer data. * to characterize the interventions enacted by our multidisciplinary supportive care team. * to explore if interventions enacted by our multidisciplinary team for patients with low recent step counts lead to increased step counts in subsequent weeks compared to historical controls. * to collect biospecimens for future correlative studies examining associations between blood/urine biomarkers and patient activity levels.

Eligibility criteria:
inclusion criteria: * age \> 18 * ecog performance status 0-2 * able to ambulate independently (without the assistance of a cane or walker) * diagnosis of invasive malignancy of the head and neck region, lung, esophagus, or stomach * planned treatment with fractionated (≥15 treatments) external beam radiotherapy with concurrent chemotherapy (or cetuximab) with curative intent (including preoperative or postoperative treatment) * women of childbearing potential must: * have a negative serum or urine pregnancy test within 72 hours prior to the start of study therapy * agree to utilize an adequate method of contraception throughout treatment and for at least 4 weeks after study therapy is completed * be advised of the importance of avoiding pregnancy during trial participation and the potential risks of an unintentional pregnancy * all patients must sign study specific informed consent prior to study entry.

Keywords: activity monitoring chemotherapy radiotherapy
study in adolescent and adult subjects 12 years of age and older with seasonal allergic rhinitis to assess onset of action

Conditions: Rhinitis, Allergic, Seasonal

Summary: allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. the focus of this study, seasonal allergic rhinitis (sar), is one type of allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. commonly referred to as "hay fever", it is characterized by sneezing, nasal congestion and pruritus, rhinorrhea, and pruritic, watery, red eyes. the purpose of this study is to evaluate the onset of action of an investigational nasal spray, gw685698x aqueous nasal spray, versus vehicle placebo nasal spray in the treatment of seasonal allergic rhinitis caused by ragweed following a single dose of treatment in controlled pollen concentrations in an allergen challenge chamber.

randomized, double blind, placebo-controlled, single-dose, parallel-group study to evaluate the onset of action of a single dose of intranasal gw685698x aqueous nasal spray 100 mcg in adolescent and adult subjects (=12 years of age) with seasonal allergic rhinitis exposed to ragweed pollen in an allergen challenge chamber

Eligibility criteria:
inclusion criteria: * informed consent * outpatient * females must use appropriate contraception * diagnosis of seasonal allergic rhinitis * able to comply with study procedures * literate exclusion criteria: * significant concomitant medical condition * use of corticosteroids, allergy medications, or tobacco * clinically significant abnormal ecg * laboratory abnormality * positive pregnancy test * allergy to any component of investigational product

Keywords: ragweed gw685698x seasonal allergic rhinitis onset
prolonged exposure therapy for post traumatic stress disorder following sexual assault

Conditions: Stress Disorders, Post-Traumatic

Summary: this study will evaluate the effectiveness of a brief cognitive behavioral therapy, administered by community agencies, for the treatment of patients with post traumatic stress disorder (ptsd).

pe is a brief cognitive behavioral therapy that can ameliorate symptoms of ptsd, depression, and anxiety in survivors of various types of trauma. pe has been successfully implemented by counselors at a community rape crisis clinic (women organized against rape \[woar\]) who received extensive training and weekly supervision from pe experts. such extensive expert involvement is not a practical model for long-term clinical practice in a community-based clinic. therefore, part 1 of this study will examine whether counselors at woar can maintain their pe implementation success with reduced expert involvement. in part 2 of this study, pe will be implemented by counselors at another community clinic (joseph j. peters institute \[jjpi\]) to examine its effectiveness in treating ptsd and to determine the generalizability of training procedures. participants in this study are randomly assigned to either pe or to individual and group therapy. treatment sessions are conducted weekly for 10 to 20 weeks, based on participants' rates of improvement. participants are assessed before treatment, after 10 weeks, and again in the follow-up phase at 3, 6, 12, and 24 months post-treatment.

Eligibility criteria:
inclusion criteria: * dsm-iv criteria for ptsd at least 12 weeks after sexual assault * ptsd symptoms that result from sexual assault and not from another traumatic experience exclusion criteria: * dsm-iv criteria for schizophrenia or delusional disorder * unstable bipolar disorder, depression with psychotic features, or depression severe enough to require immediate psychiatric treatment. clients who are medicated and still meet current criteria for these disorders will be excluded. * substance dependence * continued intimate relationship with the assailant

Keywords: rape sex offenses
weaning of nasal continuous positive airway pressure (cpap) in premature infants

Conditions: Prematurity; Respiratory Distress Syndrome, Infant

Summary: the aim of this study is to investigate two different strategies for the withdrawal of cpap in preterm infants born before 32 weeks of gestation.


Eligibility criteria:
inclusion criteria: * gestational age \< 32 weeks at birth * current gestational age \> 28+6 weeks * nasal cpap for \> 24 hours * nasal cpap pressure \< 8 cmh2o * oxygen requirement \< 30% and not increasing * respiratory rate \< 70 per minute * less than 3 episodes of oxygen saturation \< 70% or a heart rate \< 70 beat per minute in the preceding 24 hours * tolerates time off cpap during cares (up to 15 minutes) exclusion criteria: * congenital malformations of the heart (except patent ductus arteriosus, atrial septal defect and patent foramen ovale), lung, and gastrointestinal tract * surgical procedures performed on the gastrointestinal tract * known or suspected to have congenital neuromuscular disease * known or suspected syndrome

Keywords: nasal cpap weaning premature infants respiratory distress syndrome randomized controlled trial
efficacy of gastric biopsy for culture and antibiotic sensitivity assessment

Conditions: Other Diseases or Conditions | Patient

Summary: gastric biopsies will be taken to compare different methods of h.pylori disclosure.standard methods will be compared to culture.


Eligibility criteria:
inclusion criteria: * all referred for gastroscopy with clinical or endoscopic signs of peptic disease exclusion criteria: * coagulation disorders * pregnant women

Keywords: peptic disease helicobacter pylori different methods
study of hypertensive population under treatment with telmisartan in real clinical conditions with the goal to control early morning blood pressure rise

Conditions: Hypertension

Summary: the aim of the observational study is to ascertain the degree of blood pressure control in the early-morning hours after 8 weeks of treatment with telmisartan/telmisartan+hydrochlorothiazide and during 44 weeks of follow-up, in patients with hypertension using home blood pressure measurements.


Eligibility criteria:
inclusion criteria: * patients with mild to moderate essential hypertension and whose medical condition make them eligible for treatment with telmisartan/telmisartan+hctz exclusion criteria: * pre-menopausal women who had had no birth control, who are pregnant or nursing * patients with advanced hepatic impairment, advanced renal impairment or both * patients with functional class iii or iv (nyha) congestive heart failure (chf), unstable angina, acute myocardial infarction, heart surgery or stroke within the previous six months * patients with any valvular disease with hemodynamic repercussion * patients receiving chronic administration of oral anticoagulants or digoxin * patients with known hypersensitivity to any component in the formulation of micardis / micardisplus * patients with previous history of angioedema associated with ace inhibitors * patients with severe, uncontrolled hypertension or any form of secondary hypertension * patients with any other clinical conditions which, in the opinion of the investigator, would not allow for the safe completion of the protocol
short-term effects of a carob snack on postprandial glycemic responses and energy intake and satiety

Conditions: Potential Abnormality of Glucose Tolerance; Appetite; Lack or Loss, Nonorganic Origin

Summary: this study investigated any potential associations between two preloads offered as snacks and postprandial glycemic response, subjective and objective appetite and energy intake in healthy, normal-weight adults.

this study aimed at 1. firstly determine the glycemic index (gi) of a carob snack compared with an isoenergetic, equal weight chocolate cookie and 2. test the hypothesis that a carob preload consumed as snack before a meal, compared to chocolate cookie would: (a) have greater short-term effect on satiety measured by subsequent ad libitum meal intake, (b) induce greater satiety as assessed by visual analogue scales (vas), and (c) reduce postprandial glycemic response.

Eligibility criteria:
inclusion criteria: - healthy, non-smoking, non-diabetic men and women individuals with normal body mass index (bmi; between 18.5 and 24.9 kg/m2) exclusion criteria: * severe chronic disease (e.g. tumors, manifest coronary heart disease, diabetes mellitus, severe kidney or liver conditions, endocrine and immunological conditions) * gastrointestinal disorders (e.g. chronic inflammatory bowel disease) * lactose intolerance * pregnancy * competitive sports * lactation * alcohol * drug dependency

Keywords: energy intake blood glucose carob flour
primary prophylaxis for spontaneous bacterial peritonitis

Conditions: Decompensated Cirrhosis; Small Bowel Bacterial Overgrowth Syndrome

Summary: patient with liver cirrhosis commonly have co-existing small bowel bacterial overgrowth (sibo) yet may be asymptomatic. it is unclear as to the value of treating sibo in asymptomatic individuals. cirrhosis increase permeability of the gastrointestinal mucosa. it is postulated that in cirrhosis, endotoxins translocate across the gut mucosal barrier resulting in a second hit within hepatocyte perpetuating decompensation and spontaneous bacterial peritonitis. we hypothesise that cirrhosis patients with concomitant sibo are particularly vulnerable for endotoxin translocation and would benefit from treatment. treatment of sibo would reduce the risk of spontaneous bacterial peritonitis and other liver-related morbidities. we aim to treat a cohort of patients with severe liver disease and concomitant sibo with antibiotics as prophylaxis and compare the risk of spontaneous bacterial peritonitis, further liver-related morbidity and survival against untreated asymptomatic controls.


Eligibility criteria:
inclusion criteria: * decompensated liver cirrhosis (childs b \& c) with ascites. * established diagnosis of sibo exclusion criteria: * known allergy to treatment drugs * inability to undergo test confirm the success of sibo eradication; * pregnant or lactating women * terminal malignancy. * untreated viral hepatitis * alcoholic liver disease with ongoing drinking. * respiratory failure * recent antibiotics and proton-pump inhibitor within 30 days

Keywords: rifaximin
lung cancer risk and early detection in firefighters

Conditions: Lung Cancer; Lung Diseases

Summary: this study will evaluate whether ldct findings differ between firefighters and non-fighters, the relationship between occupational exposures and ldct findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.


Eligibility criteria:
inclusion criteria: * 40-80 years of age or with 10 years of firefighting experience * current or retired firefighters * no personal history of lung cancer * willing and able to receive ldct screening at mgh or who have been screened via ldct within the past year at mgh or another institution, and are willing to release their images to the study exclusion criteria: * any active cancer (undergoing treatment or diagnosed within the past 5 years)
the evaluation of the effect of microfluidic sperm sorting chip 'labs-on-a-chip' on ivf success in male factor

Conditions: Male Infertility; Infertility, Male

Summary: microfluidic chips are one of the methods of sperm separation to eliminate dna fragmentation in sperm. it is thought that the separation of sperm by centrifugation in the classical gradient density (percoll) method used in sperm separation in ivf (in vitro fertilization) laboratories leads to the increase of reactive oxygen radicals in sperm and this leads to sperm dna fragmentation. studies comparing percoll and microfluidic chip method in terms of sperm, embryo quality and pregnancy rates are limited. in this context, it is aimed to investigate the effect of percoll or microfluidic chip technology on the quality of sperms and embryos obtained with these sperms and their pregnancy rates prospectively.

the increase in male infertility rate due to environmental and physiological conditions leads to an increase in the use of assisted reproductive techniques. isolation of living and morphologically normal live sperm is an integrated procedure in commonly used ivf / icsi(intracytoplasmic sperm injection) / iui(intrauterine insemination) procedures. although current ivf / icsi procedures result in a successful pregnancy of around 50%, the process can be greatly compromised if the selected sperm is abnormal. microfluidic chips are one of the recommended sperm separation methods to eliminate dna fragmentation in sperm. it is thought that the separation of the sperm by centrifugation in the classical gradient density (percoll) method which is used in the separation of sperm in the ivf laboratories, causes the increase of reactive oxygen radicals in sperm and this leads to sperm dna fragmentation. studies comparing percoll and microfluidic chip method in terms of sperm, embryo quality and pregnancy rates are limited. in this context, it is aimed to investigate the effect of percoll or microfluidic chip technology on the quality of sperms and embryos obtained with these sperms and their pregnancy rates prospectively.

Eligibility criteria:
inclusion criteria: * apply to the ivf clinic due to male factor * volunteer exclusion criteria: * inadequate follicle development with medication * embryo does not have the appropriate quality for transfer * female-induced infertility * refuse to participate in research

Keywords: microfluid chip gradient-density ivf male factor
effect of probiotic supplement on bowel function

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to analyse the effect of probiotic supplement on symptoms of irritable bowel syndrome.

the aim of the intervention is to analyse the effect of a probiotic supplement in a dose-responsive set up on symptoms of irritable bowel syndrome (ibs). fulfillment of rome iii criteria will be used as inclusion criterion. subjective assessment of bowel symptoms, ibs-related quality of life and adequate relief will be assessed as outcome measures.

Eligibility criteria:
inclusion criteria: * subjects aged 18 to 65 with functional bowel symptoms and fulfilling rome iii criteria for ibs will be recruited. sufficient general health and orientation for participating in the study is required and will be evaluated by the mds. exclusion criteria: * diagnosed or suspected organic gastrointestinal diseases or severely impaired general health are exclusion criteria.

Keywords: irritable bowel syndrome probiotic
bivalirudin in elderly patients undergoing elective percutaneous coronary intervention.

Conditions: Acute Coronary Syndrome; Percutaneous Coronary Intervention; Aging; Anticoagulants and Bleeding Disorders

Summary: the study is an investigator-sponsored, prospective, multicenter, randomized, open-label study designed to compare efficacy and safety between bivalirudin and heparin in elderly patients with acute coronary syndrome undergoing elective percutaneous coronary intervention.


Eligibility criteria:
inclusion criteria: * age ≥75 years old; * planned elective pci for patients with acute coronary syndrome; * life expectancy ≥ 1 year; * provide written informed consent. exclusion criteria: * contraindications to angiography or pci; * active bleeding or bleeding constitution, bleeding tendency, including gi or urinary tract hemorrhage (3 months), cerebral hemorrhage (6 months) or cerebral infarction history (3 months), etc; * other disease may lead to vascular lesions and secondary bleeding factors (such as active gastric ulcer, active ulcerative colitis, intra-cerebral mass, aneurysm, etc.); * severe renal insufficiency (egfr \< 30 ml/min/ 1.73 m2); * elevated ast, alt level higher than three times of the normal upper limit; * advanced heart failure (nyha classification grading of cardiac function ≥ⅲ) complicated with immune system diseases# * abnormal hematopoietic system: platelet count \ 700 × 109 / l, white blood cell count \< 3×109/l etc; * suffering from acute infections ,infectious diseases or other serious diseases, such as malignant tumors; * known intolerance, or contraindication to any antithrombotic medication * known allergy to the study drugs and instruments (ufh, bivalirudin, aspirin and clopidogrel, stainless steel, contrast agents, etc.), or those allergic constitution. * non-cardiac co-morbid conditions are present that may result in protocol non-compliance; * patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period; * patient's inability to fully cooperate with the study protocol

Keywords: acute coronary syndrome percutaneous coronary intervention elderly bivalirudin
induction chemotherapy in young patients with locoregionally advanced nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma; Children

Summary: 1. to see the effect if a combination of induction chemotherapy followed by chemoradiotherapy works in treating children with advanced nasopharyngeal carcinoma(npc).

this phase ii trial is studying how well radiation therapy and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. radiation therapy uses high-energy x-rays to kill tumor cells. drugs used in chemotherapy, such as cisplatin and fluorouracil and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

Eligibility criteria:
inclusion criteria: * patients with newly histologically confirmed non-keratinizing (according to world health organization (who) histologically type). * original clinical staged as t4n0-3 m0 or any t、n3m0（according to the american joint committee on cancer(ajcc) 7th edition） * no evidence of distant metastasis (m0). * age ≤ 18 years old. * satisfactory performance status: karnofsky scale (kps) \> 70. * adequate marrow: leucocyte count ≥4000/μl, hemoglobin ≥90g/l and platelet count ≥100000/μl. * normal liver function test: alanine aminotransferase (alt)、aspartate aminotransferase (ast) \<1.5×upper limit of normal (uln) concomitant with alkaline phosphatase (alp) ≤2.5×uln, and bilirubin ≤uln. * adequate renal function: creatinine clearance ≥60 ml/min. * patients must be informed of the investigational nature of this study and give written informed consent. exclusion criteria: * who type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma. * age \>18 years. * treatment with palliative intent. * prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer. * pregnancy or lactation. * history of previous radiotherapy (except for non-melanomatous skin cancers outside intended rt treatment volume). * prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes. * any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \>1.5×uln), and emotional disturbance.

Keywords: induction chemotherapy nasopharyngeal carcinoma chemoradiotherapy