Kornimate/medical-research-clean huggingface dataset:
evaluation of mitochondrial function in myofascial trigger points cohort pilot study using high-resolution respirometry

Conditions: Pain, Neck; Pain, Back; Myofascial Trigger Point Pain; Myofascial Pain; Mitochondrial Pathology

Summary: this pilot study established a minimally invasive biopsy technique to obtain high-quality mtrp tissue samples to evaluate mitochondrial function via high-resolution respirometry.

myofascial trigger points (mtrps) are hyperirritable areas in the fascia of the affected muscle, possibly related to mitochondrial impairment. they can result in pain and hypoxic areas within the muscle. this pilot study established a minimally invasive biopsy technique to obtain high-quality mtrp tissue samples to evaluate mitochondrial function via high-resolution respirometry. secondary objectives included the safety of the biopsy procedure assessed via clinical wound healing (number of patients with signs for local infection and inflammation). for this purpose, twenty healthy males participated in this study, 10 with a diagnosis of myofascial pain in the musculus (m.) trapezius mtrp (ttp group) and 10 with a diagnosis of myofascial pain in the m. gluteus medius (gtp group). the affected muscle was biopsied followed by a biopsy from the vastus lateralis to be used as a control. measurements of oxygen consumption were carried out using high-resolution respirometry.

Eligibility criteria:
inclusion criteria: * male patients aged 18-45 years * clinical diagnosis of myofascial pain syndrome within the region of the shoulder-neck muscles or the lumbogluteal region and the presence of an mtrp, defined as a firm palpation of a hard, tender nodule resulting in a spontaneous pain complaint * with symptoms present for 1 to 12 months exclusion criteria: * signs that the participant's prescriptive compliance was not expected (e.g., lack of cooperation) * disorders of the respiratory tract * neurological disorders, in particular neurodegenerative and neuromuscular diseases * disorders of the cardiovascular system or the musculoskeletal system * civil servants and military service personnel.
impact of vitamine d status on in vitro fertilization outcomes

Conditions: Infertility

Summary: non skeletal effect of vitamin d have been the focus of much interest in the past decade. during the last years, special attention has been given to the impact of vitamin d on human reproduction. its receptor is expressed in most reproductive organs including hypothalamus, pituitary gland, uterus, ovary, mammary gland and the placenta. in vitro experiments suggest that vitamin d would be involved in regulated embryo-implantation. concerning amh, vitamin d seems to alters amh signaling in human granulosa cells although their circulated levels are correlated in lated reproductive aged women. the results of precedents studies about the impact of vitamin d on ivf outcomes remain conflicting the aim of our study was to assess in a large unselected population of infertile women, the impact of vitamin d deficiency on ivf outcome and to examine the relationship between serum vitamin d levels and the ovarian reserve marker amh.

vitamin d was measured on the sixth day of stimulation. according to vitamin d level, women were divided into 2 groups (deficiency when 25(oh)d \ 20 ng/ml). pregnancy rates were compared among these two groups after controlling age, bmi, characteristics of ovarian stimulation, number of ovocytes obtains, etc.

Eligibility criteria:
inclusion criteria: * patients undergoing ivf/icsi in the center of medical assistance for the procreation of the french hospital of nantes between september 2010 and may 2011. exclusion criteria: * women for who the cycle was interrupted during ovarian stimulation or converted in intrauterine insemination.

Keywords: vitamin d, 25(oh)d in vitro fertilization amh infertility clinical pregnancy
ototoxicity in patients with mom hip bearings

Conditions: Ototoxic Hearing Loss; Cobalt Poisoning; Chromium Causing Toxic Effect; Arthroplasty Complications

Summary: the goal of this observational study is to learn about ototoxicity in patients with a mom hip arthroplasty. the main question it aims to answer is: • what is the prevalence of hearing loss in patients with high and low plasma metal concentrations.


Eligibility criteria:
inclusion criteria: * all mom patients from the different clinics * revision mom * willing to participate * speak/write the dutch language exclusion criteria: * not willing to participate * previous ent surgery or ent pathology

Keywords: metal-on-metal implant; cobalt; chromium; hip arthroplasty; auditory system; otoxicity
onreltea (brimonidine) gel in pediatric patients with capillary malformations

Conditions: Capillary Malformations

Summary: capillary malformations (cm) affect a significant proportion of otherwise healthy children and may lead to psychological discomfort if left untreated. a significant proportion of untreated lesions undergo soft tissue thickening and darker discoloration later in life due to progressive ectasia of the affected vessels. while laser treatment is available, its use may be limited due to need for repeated sedation/general anesthetic use, partial response and cost. the investigators propose to conduct an open-label, prospective, cohort study using onreltea ( brimonidine) gel for treatment of facial capillary malformations in children. the study medication will be applied topically on affected area of the skin daily for 12 weeks. follow up visits will occur at at week 1,4,8,12, and 16 to assess the efficacy and safety of the proposed treatment. the study second aim is to explore the feasibility of conducting a multicenter placebo controlled study.

the investigators are planning to enroll in the study 20 participants at sickkids. it is a prospective, open label, cohort study. patients enrolled in the study will be followed at the hospital for sick children for 16 weeks. they will come for the study visits 6 times: in 1 week, 4,8,12, and 16 weeks after the treatment has been started. during each study visit the study investigators will assess any changes in the characteristics of cm lesion(s) captured by a chromometer \*, analogue scale and erythema assessment tools. participants or their parents will assess the changes at the final study visit (vas and ea tools). patients will be provided with study medication for all duration of the study treatment (12 weeks). the results of the treatment will be compared with the baseline data to evaluate the efficacy and safety of onreltea (brimonidine) gel in children with facial capillary malformations.

Eligibility criteria:
inclusion criteria: * diagnosis of facial capillary malformation (port-wine stain, pws) made by a dermatologist * age: 12-17 years of age * weight \> 45 kg * lesions with a surface area \< 100 cm2 * signed consent and assent for study participation exclusion criteria: * skin breakdown overlying the malformation due to other dermatological conditions (e.g. eczema, psoriasis) * current or treatment with laser the past 3 months * other topical treatments used within the past 4 weeks (e.g. rapamycin, corticosteroids, calcineurin inhibitors, etc) * known chronic renal or hepatic disorders * known cardiovascular disorders * other systemic medications that potentially interact with brimonidine (opiates, chlorpromazine, methyphenidate, reserpine, etc) * mixed capillary/ venous or lymphatic malformations * known allergy to one of the constituents of onreltea * pregnancy, or sexually active subjects of child-bearing potential (cbp), unwilling to use contraception during the study (such as barrier method, or oral contraceptives).

Keywords: capillary malformations onrealtea port-wine stain treatment topical
assessing the usability and clinical utility of the congo red dot test: a survey

Conditions: Preeclampsia

Summary: to determine if women can understand the instructions, carry out the test, and interpret the test results. women will be recruited to complete a test instruction and comprehension assessment and a usability assessment.

to determine if women can understand the instructions, carry out the test, and interpret the test results. women will be recruited to complete a test instruction and comprehension assessment and a usability assessment. study participants will be a convenience sample of women seeking health services. participants will first be asked to review the instructions for the congo red dot test and complete a short written questionnaire that assesses their comprehension of the test instructions. participants will then be asked to perform the test using a test control and to interpret the results obtained by answering a second written questionnaire. after the woman performs the test, a healthcare provider will use a matched control to perform a second test.

Eligibility criteria:
inclusion criteria: * eligible to consent for research * able to read spanish well enough to read the test instructions * able to give informed consent exclusion criteria: * none

Keywords: congo red dot test
an integrated approach to treating recurrent thoracic carcinomas resistant to tyrosine kinase inhibitors

Conditions: Adenocarcinoma of Lung; Lung Neoplasm; Cancer of Lung; Lung Cancer; Pulmonary Cancer; EGFR Genes; ALK Genes

Summary: patients are asked to participate in this study if they have been diagnosed with a thoracic carcinoma which includes lung cancer and have a gene mutation (alteration in the body's genetic instructions) and after undergoing treatment the cancer has come back, progressed, or shown a partial response on standard treatment.

in order to improve the treatment outcome for thoracic carcinomas after they become resistant to targeted therapy, the investigator is using tumor biopsies at the time of recurrence for genomic analysis to identify novel somatic changes in critical genes and gene pathways that can potentially be targeted with therapy. the study team is also creating patient-derived xenografts to test drug efficacy and optimize personalized therapy for each patient.

Eligibility criteria:
inclusion criteria: * 18 years or older * thoracic carcinoma tumors are positive for any targetable genetic alterations * have shown partial or no response, progression or recurrence while on or after gene targeted therapy by ct/pet scan * tumor is accessible for biopsy or surgery * expected life is 6 months or longer. exclusion criteria: * \< 18 years * not able to communicate in english
innervated sensory cross-finger flap

Conditions: Transplantation

Summary: the purpose of this study is to introduce a new operative technique for reconstruction of fingertip degloving injury.

incidence of fingertip degloving injury is common and can result in functional morbidity. a cross-finger flap based on the dorsal branch artery (dba) including sensory nerve is a useful reconstructive technique.in our modification, the innervated sensory flap is vascularized by the dba, both its pedicle is narrow and its coverage is extended, the projecting tip of exposed distal phalanx of adjacent digits therefore can be wrapped.

Eligibility criteria:
inclusion criteria: * the fingertip degloving injury including the thumb; * age between 12 and 59 years; * no life-threatening associated injuries. exclusion criteria: * age greater than 60 years; * smoking; * dupuytren's contracture; * peripheral arterial disease and other vascular disorders.

Keywords: cross-finger flap finger injuries fingertip reconstruction proper digital artery proper digital nerve.
ghrelin plus strength training in frail elderly study

Conditions: Frailty Syndrome

Summary: frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. there are currently no approved therapies for frailty. ghrelin is a hormone produced by the stomach that stimulates appetite centers in the brain. the investigators already know that a single dose of ghrelin improves food intake immediately after the dose in frail older people. in addition, exercise programs have been shown to improve strength and function in older people. in this study, the investigators are trying to find out if a joint intervention of ghrelin and resistance training will improve walking, balance and leg strength in frail elderly people.


Eligibility criteria:
inclusion criteria: * individuals with three, four or five frailty criteria using the fried frailty criteria exclusion criteria: 1. diabetes mellitus or fasting glucose ≥ 126 mg/dl 2. hospitalization for stroke, myocardial infarction, coronary artery bypass graft surgery, vascular surgery in the past six months. 3. new york heart association class iii or iv congestive heart failure 4. therapy for cancer in the past 12 months, except non-melanoma skin cancer 5. bmi ≥ 30 kg/m2 6. current use of corticosteroids other than topical, ophthalmic, and inhaled preparations 7. therapy with megestrol acetate or dronabinol within the last 6 weeks 8. thyroid stimulating hormone measured as \< 0.4 uiu/l or greater than 10uiu/l 9. abnormal liver function tests (lfts \> 2x upper limit of normal) 10. hemoglobin \< 11g/dl 11. insulin-like growth factor-i (igf-i) above the age-specific reference range 12. history of surgery within the last 30 days 13. hip fracture of hip or knee replacement within the previous 6 months or unable to walk 14. deemed unsafe to participate by one of the study exercise therapists 15. undergoing physical therapy or an exercise program 16. unstable medical or psychological conditions or unstable home or food environment 17. cognitive deficit as defined by a folstein mini mental state exam score \< 24/30 18. depression (defined as a score of \> 11 on the geriatric depression questionnaire) 19. out of town for \> 1 week during the 12 week study 20. residing outside of a 15 mile radius of university of pennsylvania health system

Keywords: frailty sarcopenia weight loss exercise aging ghrelin elderly
angiogenesis inhibitors and hypertension: clinical aspects

Conditions: Hypertension

Summary: the aim of the study is to find simple clinical and laboratory parameters to predict the development of hypertension and to elucidate the mechanism of hypertension during treatment with the tyrosine kinase inhibitor sunitinib.

inhibition of angiogenesis with antibodies against vascular endothelial growth factor (vegf) and vegf receptor antagonists has become an established treatment for cancer. an unanticipated side effect of angiogenesis inhibitors is the development of hypertension. the pathogenesis of this hypertension is unknown. not all patients will develop hypertension. however, it is not known which patient will and which patient will not develop hypertension.

Eligibility criteria:
inclusion criteria: * men and women, with either renal cell carcinoma or gastro intestinal stromal tumors (gist) intended to be treated solely with sunitinib (single-agent treatment) and who are considered fit enough by their treating physician to receive sunitinib.

Keywords: hypertension angiogenesis inhibitors tyrosine kinase inhibitor sunitinib
assessing the rates of major complications in combined mini-incision microscopic varicocelectomy

Conditions: Varicocele

Summary: the purpose of this study is to determine the rates of major post-varicocelectomy complications (recurrence, hydrocele and testicular atrophy) in patients operated with a new method named combined mini-incision microscopic varicocelectomy. the study hypothesis is that using this method will lead to less major complications of recurrence, hydrocele, and also less incidental injuries to the arteries that will result less testicular atrophy

the sample is selected from the patients who were referred to our center for surgical treatment of varicocele. most of them were diagnosed after being evaluated for infertility. all of them were operated by a single experienced and expert microscopic surgeon. informed consent is received from all of the possible candidates in accordance to national and declaration of helsinki guidelines. selection of patients for undergoing combined varicocelectomy was done during the operation due to the nature of including criteria. in this method after making an incision at inguinal level, veins are evaluated and if the including criteria is existed, only external spermatic vein is ligated at the depth of the inguinal canal and other veins are left alone for prevention of damage to the artery. then another mini incision is made at high inguinal level and the rest of surgery is conducted by retroperitoneal approach. the incidence rate of major complications (recurrence, testicular atrophy, hydrocele) of experimental group is compared to the incidence rate of the same complications of the patients in control group that were operated with currently common inguinal and subinguinal microscopic varicocelectomy accompanied by testicular delivery, an approach that is suggested by goldstein and associates. the study hypothesis is that using this method will lead to less major complications including recurrence, hydrocele and also less incidental injuries to the arteries that will result to less testicular atrophy.

Eligibility criteria:
inclusion criteria: * complexity and tortuosity of the veins at inguinal level so that separating and ligation of the vein could lead to artery injury * veins which are contiguous with arteries so that separating and ligation of the vein could lead to artery injury exclusion criteria: * prior surgery at inguinal level such as herniorrhaphy, orchiopexy,etc.

Keywords: varicocele varicocelectomy complications of varicocelectomy recurrence of varicocele post-varicocelectomy testicular atrophy post-varicocelectomy hydrocele
continuous monitoring of patients in and after the acute admission ward to optimize clinical pathways

Conditions: Monitoring; Clinical Deterioration; Acute Disease

Summary: hospitals aim to hospitalize patients when necessary and discharge patients when possible. however, the triage process and discharge management of patients in e.g. the acute admission ward, is not a trivial task. the upcoming technology of wearable monitoring devices, whereby patients can be continuously monitored with an unobtrusive vital signs device, might help getting more insight into patients' health condition and thus help facilitate efficient and effective triaging. therefore, the primary objective is to assess the effects of continuous monitoring of patients in the acute admission ward (aaw) on the percentage of patients who can be discharged home. secondary objectives are to assess the length of stay in the acute admission ward and in the in-hospital wards, as well as the effect on admission to the intensive care unit, rapid response team calls and hospital readmission. the predictive value of algorithms applied to the monitoring data combined with other parameters to detect timely deterioration and predict discharge will be assessed. facilitators and barriers for implementing such a system will be investigated.


Eligibility criteria:
inclusion criteria: in order for a patient to be eligible to participate in this study, the following criteria need to be met: * admitted to the aaw * age ≥ 18 years * able to speak and read dutch * willing and able to provide written informed consent exclusion criteria: a patient who meets any of the following criteria will be excluded from participation: * not able or willing to wear a wearable sensor on the chest continuously for 14 days * planned major surgery in the upcoming 30 days * at the time of aaw admission already known to be discharged home or admitted to the hospital * any skin condition, for example prior rash, discoloration, scars, infection, injury or open wounds at the area (left lower rib) where the sensor needs to be placed * known sensitivity to medical adhesives * wearing an active implantable device (e.g. icd, pacemaker) * intend to go to the sauna or go swimming in the upcoming 14 days * pregnant or breastfeeding * use of creams or lotions that are known to influence the skin at the area where sensor is placed (such as medical and non-medical creams or lotions)

Keywords: prediction acute admission ward continuous monitoring
a defined, plant-based, 4-week dietary intervention reduces lp(a) and other atherogenic particles

Conditions: Hypercholesterolemia

Summary: this study evaluates the effects of consuming a defined, plant-based diet on lipoprotein(a) and other atherogenic particles associated with cardiovascular disease risk.

lipoprotein(a) is a carrier of oxidized low-density lipoprotein and is a particularly atherogenic biomarker. lp(a) has been previously documented to be resistant to dietary therapies and its concentration is thought to be determined by genes. a plant-based diet has not been previously used in an attempt to influence the concentration of lp(a). participants were instructed to follow a defined, plant-based dietary intervention for four weeks. all animal products were excluded. cooked foods, free oils, soda, alcohol, and coffee were also to be excluded. all meals and snacks were provided to the participants for the full duration of the intervention. emphasized were raw fruits and vegetables, while seeds, avocado, raw oats, raw buckwheat, and dehydrated foods were prepared as condiments. vitamin, herbal, and mineral supplements were to be discontinued unless otherwise clinically indicated. participants were not advised to alter their exercise habits. serum biomarkers were obtained from participants at baseline and after 4-weeks.

Eligibility criteria:
inclusion criteria: * body mass index ≥25.0 kg/m\^2 * serum low-density lipoprotein cholesterol concentration ≥100 * systolic blood pressure ≥140 mmhg or diastolic blood pressure ≥90 exclusion criteria: * tobacco use * drug abuse * excessive alcohol consumption (\>2 glasses of wine or alcohol equivalent per day for men or \>1 glass of wine or alcohol equivalent for woman) * current cancer diagnosis * estimated glomerular filtration rate \<60 mg/dl * clinically defined infection * mental disability * hospitalization \<6 months * previous exposure to plant-based diet
surgical outcomes for proliferative diabetic retinopathy by preoperative glycemic control and renal function

Conditions: Proliferative Diabetic Retinopathy

Summary: the surgical outcomes of 25-gauge vitrectomy for proliferative diabetic retinopathy has been evaluated by preoperative glycemic control and renal function

the purpose of this study is to evaluate the surgical outcomes of 25-gauge vitrectomy for proliferative diabetic retinopathy by preoperative glycemic control and renal function.

Eligibility criteria:
inclusion criteria: * the patients had25-gauge vitrectomy for proliferative diabetic retinopathy exclusion criteria: * the patients had hemodialysis , followed up less than 6 months, had vitrectomy for diabetic macular edema and macular ration but not macular detachment.
inflammation markers in hyperemesis gravidarum

Conditions: Hyperemesis Gravidarum

Summary: in this study, the relationship between the severity of hyperemesis gravidarum (heg) disease and subclinical inflammatory factors such as platelet crit (pct), hemoglobin/red cell distribution width ratio (hrr), neutrophil/lymphocyte ratio (nlr), was investigated.

a total of 215 pregnant women, 102 with hyperemesis gravidarum and 113 healthy pregnant women, were included in the study. heg patients were divided into three groups according to the modified puqe classification: mild (n=38), moderate (n=32) and severe (n=32). in our study, we proposed using a new prognostic marker for heg patients. we think that our study will be a source for future studies on heg.

Eligibility criteria:
inclusion criteria: * healthy pregnant women over 18 years of age * 5-16 weeks of gestation. exclusion criteria: smoking, urinary tract infections, previously diagnosed psychological disorders, gastrointestinal disorders, multiple pregnancies, eating disorders, thyroid disorders, inflammatory disease, pregnancy with assisted fertilization technique.

Keywords: hyperemesis gravidarum platelet criterion (pct) hemoglobin/red cell distribution width ratio (hrr) neutrophil/lymphocyte ratio (nlr)