Kornimate/medical-research-clean huggingface dataset:
impact of empagliflozin on functional capacity in heart failure with preserved ejection fraction

Conditions: Heart Failure with Preserved Ejection Fraction; Heart Failure, Diastolic; Diabetes Mellitus

Summary: sodium-glucose cotransporter-2 (sglt-2) inhibitors generally and empagliflozin specifically have shown cardiovascular benefits in patients with heart failure (hf), but the underlying mechanisms remain unclear. empagliflozin use resulted in lower pulmonary artery diastolic pressures in patients with hf, suggesting a beneficial diuretic effect. other potential mechanisms include increased blood volume, decreased blood pressure, and changes in sympathetic and neuro-hormonal activation. this study is a single-arm, open label, prospective interventional study of 8 subjects with heart failure with preserved ejection fraction (hfpef). before and after 12 weeks of daily empagliflozin, participants with undergo comprehensive invasive exercise testing with a right heart catheter. our goal is to evaluate the effects of empagliflozin on fitness, assessed by peak vo2, and peak left ventricular filling pressure, assessed by pulmonary capillary pressure at peak exercise.

this is a single-arm, open label, pilot study of 8 subjects with hfpef. the subjects will undergo screening tests (exercise stress echo and blood work) to evaluate for potential exclusion criteria and provide familiarization to the exercise protocol. those included will undergo an echocardiogram and invasive cardiopulmonary exercise test. this involves placement of a right heart catheter in the pulmonary artery and undergoing seated, upright exercise. during the exercise test, the subject's oxygen uptake (vo2), intra-cardiac pressures (right atrial pressure, pulmonary capillary wedge pressure) and cardiac output (qc) will be measured. the subject will take a dose of empagliflozin in the lab and wait for at least 60 minutes. they will repeat a shortened version of the exercise test in the afternoon. after baseline testing, each subject will take 10mg empagliflozin daily for 12 weeks. they will have repeat blood work (specific electrolytes and renal function) 30 days after starting medication to screen for renal injury. after 12 weeks, they will return for another invasive cardiopulmonary exercise test and echocardiogram.

Eligibility criteria:
inclusion criteria: * adults ages 50-85 * clinical heart failure * ejection fraction \> 50% exclusion criteria: * previous hypersensitivity or adverse reaction to sglt-2 inhibitors * currently treated with sglt-2 inhibitor * current or prior ejection fraction \<50% * chronic kidney disease with glomerular filtration rate \< 45 ml/kg/min * unstable coronary artery disease * significant arrhythmia * bmi \>55 kg/m2 * inability to exercise.

Keywords: exercise invasive exercise testing sglt-2 inhibitors
insertion of frontal ventricular catheter of vp shunt in congenital hydrocephalus guided by trans fontanelle ultrasound

Conditions: Ventriculoperitoneal Shunt; Trans Fontanelle US; Congenital Hydrocephalus

Summary: the aim of this study is to evaluate the role of ultrasound in decreasing rate of proximal obstruction in frontal vp shunt

congenital hydrocephalus is a very common congenital anomalie known as the abnormal accumulation of csf in the ventricles and subarachnoid spaces under high tension due to imbalance between synthesis and absorption of csf , the incidence of congenital hydrocephalus is higher in low income country than in high income countries treatment options for hydrocephalus are multiple but the most common treatment option world wide is vp shunt . although, vp shunt still has a high rate of failure as revisions are required in 30% - 40% of cases in vp shunt insertion , the placement of ventricular catheter is done mainly by free hand technique but recently the trans fontanelle ultrasound guided placement of ventricular catheter become a standard technique in multiple centers the free hand technique has low accuracy rate in proper intraventricular placement of the proximal catheter than the ultrasound guided technique . on the other hand , the use of intra operative ultrasound can visualize the anatomy of lateral ventricles and choroid plexus which makes the placement of ventricular catheter more accurate than the blind free hand technique so we are aiming in this study to highlight the efficacy of ultrasound guided placement of ventricular catheter of the frontal shunt in decreasing the rate of proximal catheter obstruction and we choose the frontal shunt because it has an advantage over the occipital in rate of revisions as it has a lower rate

Eligibility criteria:
inclusion criteria: * patients who are diagnosed with congenital hydrocephalus * age of patients : \< 2 years with patent anterior fontanelle * not operated with frontal shunt before exclusion criteria: * patients who are diagnosed with congenital hydrocephalus * age of patients : \< 2 years with patent anterior fontanelle * not operated with frontal shunt before

Keywords: ventriculoperitoneal shunt trans fontanelle us congenital hydrocephalus
pomegranate supplementation and well-being among medical students and residents

Conditions: Antioxidant; Burnout, Professional; Psychological Distress

Summary: medical students and residents have high rates of mental distress and burnout related to the intellectual and time demands of their training. research shows that physiological stress on the body can be a result of fatigue and high stress work, and is associated with experiences related to mental distress. pomegranate is a fruit that is known to contain a variety of antioxidant substances that can reduce physiological stress. this study will look at the potential for pomegranate supplementation to reduce physiological stress and improve well-being in medical students and residents.

this is a pilot study to investigate the feasibility of conducting a randomized trial of pomegranate supplementation in medical students and residents, and to see whether there is evidence of an effect on reported emotional and physical well-being. phase 1 will be a pilot with 10 participants in which all will receive the pomegranate supplement for 28 days. in phase 2, we will randomize 40 participants (1:1) to receive either the pomegranate supplement or a placebo. for both phases, we will measure self reported emotional and physical well-being using several questionnaires, and we will conduct laboratory testing for measures of oxidative stress and inflammatory biomarkers in blood, and for a metabolite of pomegranate in urine.

Eligibility criteria:
inclusion criteria: * first or second year medical student or first or second year resident listed at the university of mississippi medical center exclusion criteria: * pregnant or planning to become pregnant during the study period. * breast feeding. * unable to speak, understand, and read english. * taking chronic medications other than contraception * taking supplements (including over-the-counter multivitamins) * allergy to pomegranate or gelatin (gel-caps) * baseline scores on the dass-21 that indicate a level of depressive or anxiety symptoms that is "severe" or "extremely severe." this would be a depression score greater than 10, or an anxiety score greater than 7.

Keywords: pomegranate burnout psychological distress antioxidant
influence of whole body vibration compared to conventional physiotherapy in patients with gonarthrosis

Conditions: Osteoarthritis

Summary: 40 patients with osteoarthritis of the knee will be randomly assigned to conventional physiotherapy on the one and whole body vibration exercises on the other hand. the duration of the training will be 6 weeks, three times a week. the outcome will be measured by womac and sf-12 scores relating to pain and quality of life. the second outcome criteria will be a motion analysis and balance testing before and after the training. the follow-up is 26 weeks.


Eligibility criteria:
inclusion criteria: * 30-80 years old * womac 30-70 mm (vas) * gonarthrosis (kellgren/lawrence) ii-iii exclusion criteria: * womac \>70 mm (vas) * endoprosthesis in lower extremity * bmi \>40 kg/m2

Keywords: galileo whole body vibration osteoarthritis knee physiotherapy
effect of colloids versus crystalloids on heart mechanics: a double-blind cross over randomized trial

Conditions: Fluid Reponsiveness; Fluid Resuscitation; Fluid Therapy

Summary: the debate over whether to use colloid or crystalloid solutions for fluid resuscitationis still ongoing. colloid solutions consist of large molecules that generally cannot pass through healthy capillary membranes, whereas crystalloid solutions contain ions that easily move from the intravascular space to the interstitial compartment. therefore, it is traditionally argued that colloids are more effective at expanding intravascular volume, with a suggested ratio of 1:3 compared to crystalloids. however, there is currently limited evidence to suggest that resuscitation with one type of fluid is more effective or safer than t he other. despite these theoretically advantageousphysiological properties, colloids have not demonstrated a clear hemodynamic benefit over crystalloids. we hypothesized that these unexpected discrepancies may be attributed to different mechanical heart responses.


Eligibility criteria:
inclusion criteria: * healthyvolunteers with age \> 18 years without medical history exclusion criteria: history of cardio vascular diseases diabetes hypertension currentpregnancy knownallergy to one of the tested products leftventricular dysfunction discovered at baseline assessment valvular heart or other structural diseases discovered at base line assessment

Keywords: colloids cristalloids heart mechanics
plant sterol-enriched palm oil to improve lipid profile and inflammation in hyperlipidemic individuals

Conditions: Hyperlipidemias

Summary: this is a placebo-controlled double-blinded trial aimed to evaluate the effect of palm oil enriched with plant sterols on lipid profile and systemic inflammation marker in 100 adult hyperlipidemic residents of bogor, indonesia. subjects were assigned to intervention oil which contained plant sterol and control oil which was the same as the intervention oil but did not contain plant sterol for 8 weeks. data collected included nutritional status, energy and macronutrients consumption, blood lipid profile and inflammatory marker (hscrp).

cardiovascular diseases, including coronary heart disease (chd), are currently positioned amongst the leading causes of mortality globally. risk factors of chd include, among others, hypercholesterolemia and elevations in systemic inflammation. functional foods enriched with compounds showing cholesterol-lowering effects are considered as one among various dietary and lifestyle intervention strategies to tackle this problem. a chd-preventive effect of dietary plant sterols has been broadly discussed, not only due to their ability to reduce blood cholesterol level, but also to their proven anti-inflammatory potential. palm oil is one amongst the most widely consumed edible oils in the world. up to date, despite its widespread use, especially in asian countries, no study has been conducted using palm oil as a vehicle for plant sterols. the aim of the placebo-controlled double-blinded trial presented here was therefore to evaluate the effect of palm oil enriched with plant sterols, used as a cooking oil, on lipid profile and systemic inflammation marker in 100 adult hyperlipidemic residents of bogor, indonesia. the study had 2 arms; intervention group in which subjects were given oil which contained plant sterol and control group which in which subjects were given the same oil as the intervention group but did not contain plant sterol for 8 weeks. the oil was consumed as cooking oil. data on energy, macro nutrients, and cooking oil consumption were collected through interviews at baseline, week 2, 4, 6, and endline. body weight and height measurement for nutritional status assessment and blood sample collection for biomarker analysis was conducted at baseline and endline.

Eligibility criteria:
inclusion criteria: * aged 25-60y * total cholesterol concentration ≥200 mg/dl * not requiring lipid-lowering drug therapy during the trial exclusion criteria: * secondary hyperlipidemia * fasting triglyceride concentration \>3.5 mmol/l * body mass index \>35 kg/m2 * use of any lipid-lowering drug * suffering from gastrointestinal diseases or severe concomitant diseases

Keywords: hyperlipidemia plant sterol c-reactive protein indonesia
effects of red light led therapy on body contouring

Conditions: Obesity

Summary: red light laser therapy using 635nm red light laser technology has previously been shown to cause lipolysis in subcutaneous fat as a non-surgical method to promote weight loss and body contouring. this study hypothesizes that red led light therapy using 650nm red light led (light emitting diode) technology produces similar results to the laser device (red laser 635nm) when preformed using a specified treatment protocol.

red light laser therapy using 635nm red light laser technology has previously been shown to cause lipolysis in subcutaneous fat as a non-surgical method to promote weight loss and body contouring. this study hypothesizes that red led light therapy using 650nm red light led (light emitting diode) technology produces similar results to the laser device (red laser 635nm) when preformed using a specified treatment protocol. furthermore, it is hypothesized that the vevazz therapy program achieves the results after one 28 minute treatment period. the predicate 635nm led device (photonica professional by ward photonics) achieves its results after one 32 minute therapy program. the fb professional therapy program uses the fb professional led device for fat removal using led red light therapy. this multi-site study reviews results from 70 randomly selected patients after a single treatment using the fb professional led device.

Eligibility criteria:
inclusion criteria: * at least 18 years or older. * may be male or female. * generally good health. exclusion criteria: * minors. * open wounds or sores. * pacemaker. * photosensitivity. * epilepsy. * any form of cancer. * severe kidney or liver problems. * thyroid problems. * pregnant or nursing.
the role and effect of anemia in children with pneumonia

Conditions: Anemia; Pneumonia

Summary: this study will measure the effect of anemia on the outcomes of hospitalized children with severe pneumonia.


Eligibility criteria:
inclusion criteria: * age 6 months to 59 months * who-defined severe pneumonia exclusion criteria: * congenital heart disease
investigational parkinson's disease in patients not well controlled on l-dopa

Conditions: Parkinson Disease

Summary: the purpose of this double-blind, placebo controlled study is to evaluate the safety and effectiveness of an investigational parkinson's disease drug in patients with advanced disease who are not well-controlled on their l-dopa medication.


Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease * modified hoehn and yahr scale stages ii - iv * stable dose of l-dopa for at least 4 weeks prior to screening. * lack of control with l-dopa therapy. * women of child-bearing potential must use a clinically accepted form of birth control. exclusion criteria: * significant and/or uncontrolled medical conditions (excluding parkinson's disease) within 3 months of screening. * any abnormality, at screening, that is considered clinically relevant by the investigator. * dementia * use of dopamine agonists within 4 weeks of screening visit. * participation in other investigational drug studies.

Keywords: parkinson's disease dyskinesia adjunctive therapy with l-dopa
study evaluating hki-272 in tumors

Conditions: Breast Neoplasms

Summary: the purpose of this study is to evaluate the safety and tolerability as well as find the maximum tolerated dose (mtd) for hki-272. in addition, this study will examine the effects of the study drug on your tumor, and how your body uses and eliminates hki-272.


Eligibility criteria:
inclusion criteria: * her2/neu or her1/egfr positive cancer * eastern cooperative oncology group (ecog) performance status of 0 to 2 * measurable disease as defined by response evaluation criteria in solid tumors (recist) exclusion criteria: * prior treatment with anthracyclines with a cumulative dose of doxorubicin or equivalent of greater than 300 mg/m\^2 * patients with significant cardiac risk factors * active central nervous system metastasis

Keywords: tumors neratinib hki-272 nerlynx
magnetocardiography using a novel analysis system (cardioflux) in the evaluation of emergency department observation unit chest pain patients

Conditions: Acute Coronary Syndrome; Myocardial Infarction

Summary: genetesis is a cardiac diagnostics company which presents a novel magnetocardiogram (mcg) analysis system called cardioflux. this investigation presents a new, noninvasive diagnostic option to use mcg for rapid diagnosis of acute coronary syndrome. data from the cardioflux system will be compared with stress testing methods as well as the results of cardiac catheterization to identify patients with myocardial ischemia. this is a prospective observational single-blinded convenience pilot study of 100 patients placed in the clinical decision unit (cdu) for evaluation of chest pain at st. john hospital and medical center (detroit, mi). patients enrolled in the study will also have a 30 and 180 day follow up for analysis of adverse cardiac events.


Eligibility criteria:
inclusion criteria: low and intermediate risk ed patients presenting with chest pain of possible cardiac origin who have a negative first troponin result and non-diagnostic ecg that are to be placed in the cardiac diagnostic unit (cdu) for further evaluation. exclusion criteria: 1. ≤ 18 years of age 2. patients unable to fit into device 3. non-ambulatory patients 4. patients with any implantable device or metal in the thorax area (e.g. pacemaker, aicd, bullet fragments in thorax) 5. patients with claustrophobia 6. pregnant women 7. poor candidate for follow-up 8. prisoners 9. repeat participants

Keywords: magnetocardiography chest pain
ilizarov frame or uni planar external fixator in the cost-conscious era

Conditions: Tibia Fracture

Summary: tibial shaft fracture is a common injury worldwide. their treatment, prognosis, and outcome are determined by the mechanism of injury, presence of communition, soft tissue injury and displacement. in developing countries, lack of education,socioeconomic backgrounds, delay in presentation and appropriate planning for surgery add further to complicate the situation and may end in delayed union, non-union, multiple surgeries and ultimate results in increased morbidity. this study was conducted to determine the outcome of open tibia shaft fracture treated with ilizarov or ao external fixator.

tibial shaft fracture is a common injury worldwide. their treatment, prognosis, and outcome are determined by the mechanism of injury, presence of communition, soft tissue injury and displacement. in developing countries, lack of education,socioeconomic backgrounds, delay in presentation and appropriate planning for surgery add further to complicate the situation and may end in delayed union, non-union, multiple surgeries and ultimate results in increased morbidity. this study was conducted to determine the outcome of open tibia shaft fracture treated with ilizarov or ao external fixator. it was retrospective cohort study. two groups were compared in terms of fracture healing, mechanism of injury, fracture classification, participant's ambulation at discharge, new injury severity score (niss), duration of hospital stay, duration of fracture union, need for secondary procedures and complications. investigators concluded that circular fixator application has favorable outcomes for gustilo grade iii open tibial shaft fractures as compared to uniplanar external fixator.

Eligibility criteria:
inclusion criteria: participants with open tibia shaft fracture type iii (a, b, c) as per gustillo classification of open fractures stabilized with external fixation either circular or uniplanar external fixator were included exclusion criteria: * all closed and type i and ii open tibia shaft fractures according to gustillo classification of open fracture, intra-articular fracture extending to knee and ankle joints were excluded.

Keywords: tibia fracture; ilizarov; open fracture; external fixator
diagnosis of lung complication after allo-hsct by multiple parameter system through bal

Conditions: Bronchoalveolar Lavage Fluid; Lung Infection

Summary: the aim of this study was to evaluate the diagnostic yield for lung complication after allo-hsct by multiple parameter system through bal.

一) adult patients with hematology disease under allo-hsct at any phase of treatment are enrolled according to the following criteria: 1. lung infiltration detection at computed tomography (ct) scan. 2. patients with fever, cough, respiratory symptoms. according to the investigators, the patients fulfilling these criteria undergo bal as soon as possible 二) the balf samples were tested using such methods 1. classic microbiological cultures designed for bacteria, fungi, and mycobacteria. 2. detection of human cytomegalovirus (cmv) and eb virus in serum and bal was tested using a real-time pcr kit. 3. detection of aspergillus galactomannan antigen 1,3-beta-d-glucan in serum and bal was performed using an enzyme immunoassay method. 4. cytological and pathogenic microscopic evaluation in balf 5. flow cytological analysis of t lymphocyte subsets in balf and serum 6. cytokine detection in balf and serum 7. microbiology detection in balf by mngs 三) pathogenic spectrum analysis and targeted etiological therapy

Eligibility criteria:
inclusion criteria: 1. diagnosed with hematological diseases. 2. recipients of allogeneic peripheral blood stem cell transplantation. 3. lung infiltration detection at computed tomography (ct) scan. 4. patients with fever, cough, respiratory symptoms. 5. consent to bal and follow-up observation after bal exclusion criteria: 1. severe bleeding tendency, platelet less than 20000/ul, or severe coagulation dysfunction; 2. multiple bullae are at risk of rupture; 3. untreated patients with active pulmonary tuberculosis; 4. patients with severe consumptive diseases or conditions and various causes can not cooperate well 5. cardiac insufficiency, severe pulmonary ventilation dysfunction 6. recent massive hemoptysis 7. aortic aneurysm and esophageal varices are at risk of rupture

Keywords: idiopathic pneumonia syndrome cmv pneumonia pneumocystis jiroveci pneumonia invasive pulmonary aspergillosis
occurence of pain and use of analgesic treatment in multi-trauma patients of intermediate seveity

Conditions: Post Traumatic Pain; Post Traumatic Analgesic Treatment

Summary: to register the perceived pain score during 0-14 days after multitrauma in conscious patients and to register the use (type and dose) of analgesic treatment in the same period.


Eligibility criteria:
inclusion criteria: * patient with trauma, iss \> 8 exclusion criteria: * unconscious patients at admission * patients due for major surgery within 3 hrs of admission * patients primary admitted to other hospitals * not able to communicate in norewegian