Kornimate/medical-research-clean huggingface dataset:
postoperative score predictive of the prognosis of acetabular fractures

Conditions: Acetabular Fracture

Summary: acetal fractures are joint fractures that occur in the hip. these fractures affect the functional prognosis of the hip in the short, medium and long term. in the acetabulum fractures operated on, there is a radiological score in the literature allowing the prognosis to be predicted depending on the quality of the postoperative reduction. this score is based on the quality of postoperative reduction assessed on pelvic radios. in addition, the thresholds for poor / good results were determined empirically.


Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * patient operated on for an acetabular fracture at the ghpsj between january 2004 and december 2014 * patient with a minimum postoperative follow-up of 2 years * french-speaking patient exclusion criteria: * patient treated conservatively. * patient under guardianship or curatorship * patient deprived of liberty * patient under legal protection * patient objecting to the use of his medical data as part of this study
evaluating an online training program on shared decision-making in prenatal screening

Conditions: Shared Decision Making

Summary: the investigators aim to evaluate an online training program on shared decision making within the prenatal context. the main outcome is intention on using a decision aid in prenatal screening consultation and study population is nurses. secondary outcomes are; knowledge acquisition, acceptability of the formation and perceived usefulness. the investigators hypothesise that this web-based sdm training program developed for the prenatal screening of down syndrome will significantly increase nurses' intentions to use the decision aid in their clinical practice with pregnant women and their partner.

pregnant women have difficulty choosing among the wide variety of prenatal screening options available. to help pregnant women and their partners make informed decisions based on their values, needs and preferences, a decision aid (da) has been developped and online shared decision-making (sdm) training program for health professionals has been created to support the use of this da and give health care professionals key elements on sdm. the decision aid was found relevant and acceptable to pregnant women and their partners; the relevance and acceptability of the online sdm training program aren't evaluated yet. this study aim to assess the intention on using a da after taking the online training program, to evaluate knowledge acquisition and to assess the program's acceptability and perceived usefulness. this is a multi-center, two-arm, controlled trial (rct). thirty-six participants will be randomly allocated to either 1) an experimental group that is exposed to the investigator's complete 3 hours online training program intervention (n = 18) or 2) a control group that is exposed to an intervention which will be a 3 hours online training program focused on prenatal screening alone.

Eligibility criteria:
inclusion criteria: * be a certified nurse * be involved in supporting prenatal screening decision-making or involved in prenatal screening processes in the province of quebec; * speak and write in french * being in active practice within the last year. exclusion criteria: * none

Keywords: shared decision making decision aid nurse online training
retrobulbar triamcinolone acetonide injection in the treatment of na-aion

Conditions: Triamcinolone Acetonide; Optic Neuropathy, Ischemic

Summary: naion produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it. intravenous injection of glucocorticoid have proven to be effective in treatment of nonarteritic anterior ischemic optic neuropathy,but have some side effects. the investigators believe that offering them retrobulbar triamcinolone acetonide injection that might halt the progression of the visual acuity and visual field loss if our hypothesis is correct, would greatly improve their chances of avoiding blindness.


Eligibility criteria:
inclusion criteria: sudden mono ocular vision loss associated with optic disc edema and positive marcus gunn (\<30 days) exclusion criteria: any eye disease except naion(nonarteritic anterior ischemic optic neuropathy) neurologic defect abnormal esr, crp, any history of retina or vitreal surgery severe corneal opacity which makes retina examination impossible
safety and efficacy of co-administration of sitagliptin and metformin in china (mk-0431-121)

Conditions: Type 2 Diabetes Mellitus

Summary: this study will assess the efficacy and safety of initial treatment with sitagliptin and metformin in patients with type 2 diabetes mellitus in china. the primary hypothesis is that after 24 weeks, initial co-administration treatment with sitagliptin and metformin provided greater reduction in hemoglobin a1c (a1c) compared to initial treatment with sitagliptin alone and with metformin alone.


Eligibility criteria:
inclusion criteria: * has type 2 diabetes mellitus * is male, a female who cannot have children, or a female who agrees to use birth control during the study * is not on an antihyperglycemic agent (aha) (hemoglobin a1c \[a1c\] 7.5-11.0%) or on oral single aha (a1c 7.0-10.5%) or low-dose aha combination therapy (a1c 7.0-10.0%) exclusion criteria: * patient has type 1 diabetes mellitus or ketoacidosis * patient is taking a dipeptidyl peptidase-4 (dpp-4) inhibitor (such as sitagliptin) * patient is on a weight loss program not in the maintenance phase or on a weight loss medication * patient has a history of liver disease, heart failure, heart disease, stroke, high blood pressure, blood disorders, or cancer * patient is hiv positive * patient is pregnant
genome-wide analysis of single nucleotide polymorphisms of brain arteriovenous malformations and cerebral aneurysm

Conditions: Arteriovenous Malformations; Intracranial Aneurysm; Subarachnoid Hemorrhage

Summary: test single nucleotide polymorphisms (snp's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test snp's in arteriovenous malformation tissue to identify a genetic link.


Eligibility criteria:
inclusion criteria: * all adult patients between the ages of 18 and 89 that are having open surgical resection of an avm or clipping of an aneurysm will be included exclusion criteria:
management of diverticulitis in the emergency department

Conditions: Diverticulitis

Summary: this study aims to describe current treatment practices in the us for managing acute uncomplicated diverticulitis. in addition, we will identify clinical factors associated with the decision to discharge versus hospitalize patients with uncomplicated diverticulitis with the goal of informing clinical decision-making and providing a foundation for diagnostic algorithms to guide clinical practice.


Eligibility criteria:
inclusion criteria: * age ≥18 years * emergency department presumptive or confirmed final diagnosis of acute diverticulitis * verbal or written consent provided in english (or spanish depending on study site) exclusion criteria: * none
microbiome of donor iron deficient study

Conditions: Iron Deficiency

Summary: the goal of this pilot study is to test whether the microbiome is affected by intravenous iron repletion.

the colonic microbiome, the community of bacteria living in our gut, is essential in human health and disease. iron is an essential nutrient for both bacteria and humans. in the united states, of the donors who provided the \~15 million units of red blood cells that were collected for transfusion, 69% were repeat donors. although iron deficiency is surprisingly prevalent in first-time donors, its prevalence is even higher in these particularly altruistic frequent donors, (i.e., up to 49% and 66% of male and female repeat donors, respectively), manifested as iron depletion or iron-deficient erythropoiesis. iron deficiency from blood donation is associated with fatigue, restless leg syndrome, decreased physical endurance and work capacity, and impaired concentration, attention, and other neurocognitive functions; however, these conclusions are not based on definitive studies and have not yet changed blood donation policy. the goal is to conduct a prospective, double-blind, randomized controlled trial, recruiting 60 healthy regular donors who meet donation standards, while exhibiting iron-deficient erythropoiesis by laboratory test criteria. in this ancillary study, we will determine what effect donor iron deficiency and iv iron repletion have on the gut microbiome.

Eligibility criteria:
inclusion criteria: * current participant of the associated randomized controlled trial conducted at columbia university medical center (therefore invited to participate in this optional ancillary study). exclusion criteria: * not a current participant of the associated randomized controlled trial conducted at columbia university medical center.

Keywords: blood donation iron repletion transfusion
a phase i study of bi-weekly rbbx-01 in patients with solid tumors

Conditions: Solid Tumors

Summary: this study will evaluate toxicity associated with escalating doses of rbbx-01 given bi-weekly to patients with solid tumors.


Eligibility criteria:
inclusion criteria: * confirmed metastatic or unresectable, resistant solid tumor. gynecologic tumors preferred. * 18 years and above * gog performance status greater than or equal to 2 * life expectancy greater than 6 months * acceptable organ and marrow function * willingness to agree to use adequate contraception prior to study entry and for the duration of study participation exclusion criteria: * chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin c) prior to entering the study or have not recovered from adverse events due to agents administered more than 4 weeks earlier * not receiving any other investigational agents * known brain metastasis * uncontrolled intercurrent illness including, but not limited to ongoing ore active infection, symptomatic congestive heart failure, unstable angina pectoris,cardiac arrythmia, or psychiatric illness/social situations that would limit compliance with study requirements * pregnancy * immunosuppression including subjects with known hiv infection on immunosuppressive drugs or having an autoimmune disorder * penicillin allergy * symptomatic prostate hypertrophy

Keywords: malignant resistant solid tumor
onset and duration of mometasone by oscillometry and spirometry

Conditions: Asthma

Summary: inhaled corticosteroids (ics) are appreciated for their long term anti-inflammatory effects in chronic asthma. however, they also have largely unappreciated early effects when initiated as a controller therapy in a steroid-naïve population. impulse oscillometry might reveal such an early effect better than spirometry. the investigators sought to examine the onset of action and sustained effects over 4 weeks treatment of mometasone furoate as measured by impulse oscillometry system (ios) versus spirometry.


Eligibility criteria:
inclusion criteria: * age between 18-65 years inclusive. * written informed consent (conducted according to the gcp and ich guidelines) to participate in the study. ability to comply with all study requirements. * mild to moderate persistent asthma with symptoms at least 2 times per week, managed by as-needed saba only. * a 35% or greater improvement in small airway dysfunction defined by ios ax after inhaled saba. * allergic response to one or more common allergens at screening via skin test. * male, or female of childbearing potential using a medically approved birth control method. * evidence of sad manifested by an index of peripheral airway reactance of \> 10.5 cm h2o/l (3 times the upper limit of adult normal). * symptoms of airflow obstruction (i.e. dyspnea on exertion greater than peers at similar exercise levels, wheeze, or cough \> 3 weeks without respiratory infection, or nocturnal dyspnea, and use of saba \> 2 times per week) exclusion criteria: * subjects with severe persistent asthma and/or subjects taking inhaled or systemic corticosteroids or long acting beta agonists (laba). * subjects \ 65 years. * pregnant or lactating females. * history of diabetes. * acute infections within 4 weeks prior to screening. * concurrent medical condition that might interfere with the interpretation of efficacy and safety data during the study. * contraindications and warnings according to the specific label for asmanex. * chronic inhaled or systemic corticosteroid treatment (\> 7 consecutive days of treatment) within 30 days prior to screening. * investigational drug treatment within 30 days prior to screening. treatment with any drug with a known and frequent toxicity to a major organ system within the past 60 days.

Keywords: asthma fev1 and ios change after mometasone for asthma
rescue stenting in the severe atherosclerotic stenosis after the failure of intravenous thrombolysis

Conditions: Ischemic Stroke, Acute; Stent Stenosis; Thrombosis

Summary: intravenous (iv) recombinant tissue plasminogen activator is the standard of care for patients with acute ischemic stroke (ais) who present to the hospital within 4.5 hours of symptom onset. however, iv thrombolysis, even bridging thrombolysis (combining intravenous thrombolysis and mechanical thrombectomy) has limited efficacy among patients who had occlusive lesions associated with highgrade arterial stenosis requiring revascularization to improve neurological deficits. the investigators evaluated whether rescue stenting results in good outcomes among patients after the failure of intravenous thrombolysis and bridging thrombolysis.

stroke is the second most common cause of death worldwide, with an annual mortality rate of approximately 5.5 million. depending on the timing of presentation, intravenous (iv) administration of recombinant tissue plasminogen activator can be an effective treatment, but is most effective when used between 3 and 4.5 hours of symptom onset. bridging thrombolysis, which describes the combination of iv thrombolysis and mechanical thrombectomy, can lead to long-term functional independence after 90 days with higher recanalization success rates than iv thrombolysis alone without increased risk. the hermes meta-analysis of fve trials (mr clean, escape, revascat, swift prime, and extend ia) indicated the potential benefits of mechanical thrombectomy (mt) in case of proximal circulation occlusions. the recanalization failure rate of this treatment, defined as a modified thrombolysis in cerebral ischemia (mtici) score of 2a or worse, remained high, ranging from 13% to 29%, and most patients experienced poor clinical outcomes. permanent stent placement has been suggested as a potential approach for achieving successful recanalization, which is the goal of endovascular therapy in the early management of acute ischemic stroke (ais). however, the risk of intracranial hemorrhage associated with the combined use of iv thrombolysis and a loading dose of dual antiplatelet therapy (dapt) increases when rescue stenting is applied. the investigators hypothesize that stent deployment might serve as a feasible treatment for large artery occlusion after the failure of intravenous thrombolysis and bridging thrombolysis.

Eligibility criteria:
inclusion criteria: * acute ischemic stroke who underwent rescue stenting for large vessel occlusions underlying severe atherosclerotic stenosis after the failure of intravenous alteplase therapy. * absence of intracranial hemorrhage. exclusion criteria: * premorbid modified rankin scale (mrs) ≥ 2 * initiation to rescue stenting beyond 24 hours after symptom onset

Keywords: ischemic stroke rescue stenting intravenous thrombolysis dual antiplatelet therapy
a study comparing two methods of placing an interscalene nerve catheter for postoperative pain control in patients who undergo open shoulder surgery.

Conditions: Shoulder Pain

Summary: this is a randomized, double-blinded, prospective study designed to compare two approaches (in the plane of the ultrasound beam and out of the plane of the ultrasound beam) to placing an interscalene nerve block and catheter for pain control after open shoulder surgery. both approaches have been used successfully but neither has been proven to be superior. our endpoints are pain scores, time for block placement, and catheter dislodgements. we hypothesized that patients with the out-of-plane approach would have decreased pain and fewer catheter dislodgements.

interscalene nerve block is an effective method of analgesia for surgery of the upper extremity. perineural interscalene catheters offer the advantage of extended pain relief up to 48 hours after shoulder surgery. this is a prospective, randomized trial designed to compare two approaches (posterior and anterolateral) to interscalene continuous nerve catheter placement for analgesia after open shoulder surgery (open rotator cuff repair, total shoulder arthroplasty or revision, hemi-arthroplasty, or proximal humerus open reduction internal fixation). specifically, the objectives of this study are to compare measured pain scores, opioid consumption, and catheter dislodgements. we hypothesize that the anterolateral approach will produce lower pain scores, less opioid consumption, and fewer catheter dislodgements. all patients undergoing open shoulder surgery will be recruited and enrollment in the study will not deviate from the current standard of care at thomas jefferson university hospital. all nerve blocks will be placed by a regional anesthesiologist or a fellow in regional anesthesia. patient medical history will be obtained and blocks will be placed per usual protocol. block efficacy will be assessed by physical exam immediately after placement by the anesthesiologist and another member of the research team. operative details, including medications given, will be recorded. patient pain scores and medications given in the pacu will be recorded. supplementary analgesics will be available. pain scores, medications given, and sensory examinations will be recorded for 48 hours postoperatively. data will be analyzed both at the conclusion of the study and at several interims before that.

Eligibility criteria:
inclusion criteria: * speaks english exclusion criteria: * children, * neuropathy in operative arm

Keywords: interscalene nerve block nerve catheter in-plane out-of-plane anterolateral approach posterior approach shoulder surgery
effects of scapular stabilization versus thoracic spine extension exercises in mechanical neck pain

Conditions: Neck Pain

Summary: mechanical neck pain is posteriorly occurring non-specific pain that originates from the superior nuchal line and extends to the first thoracic vertebrae. it is exacerbated by sustained neck postures, neck movements or cervical muscle palpation. the aim of study will be to compare the effects of scapular stabilization versus thoracic spine extension exercises on pain, disability and range of motion in patients with mechanical neck pain.

a randomized clinical trial will be conducted at riphah clinic lahore, fmh physiotherapy clinic and boston physiotherapy clinic lahore through consecutive sampling technique on 30 patients which will be allocated using simple random sampling through sealed opaque enveloped into group a and group b. group a will be treated with scapular stabilization exercises and group b will be treated with thoracic extension exercises at the frequency of 2 sets with 10 repetitions and thrice a week. outcome measures will be conducted through pain, disability and range of motion questionnaire after 6 weeks. data will be analyzed during spss software version 21. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * males and females between 18 and 40 years of age with mechanical neck pain. (symptoms provoked by neck movement and/or palpation of musculature of the cervical region) * chronic mechanical neck pain for more than 3 months. exclusion criteria: * cervical radiculopathy * traumatic neck injury * history of cervical and thoracic spine surgery * neck pain associated with vertigo * osteoporosis * vertebral fractures * tumors * pregnancy * diagnosed psychological disorders

Keywords: disability physical muscle strength range of motion
whole body electromyostimulation and nutritional therapy for patients with chronic liver disease

Conditions: Liver Diseases

Summary: the purpose of this study is to explore the influence of an innovative combined therapy involving optimized protein-rich nutritional therapy and highly effective muscle training by personalized whole-body electromyostimulation (wb-ems) exercise to improve muscle mass, strength and functionality, physical capacity, fatigue and quality of life of patients with chronic liver disease.

in the course of chronic liver disease a systemic inflammatory reaction promotes mediators leading to a loss of appetite, as well as to metabolic and hormonal changes. consequences hereof are a decreased food uptake, a deteriorated nutrient utilization and a loss of muscles, with or without fat loss leading to cachexia. especially muscle loss has a relevant influence on morbidity and mortality of chronic liver patients. the loss of muscle is probably due to a deteriorated protein synthesis with concurrent anabolic resistance. these pathologic processes increase the protein requirements of chronic liver patients dramatically. the purpose of this study is to establish an innovative combined therapy involving optimized nutritional therapy and highly effective muscle training by personalized whole-body electromyostimulation (wb-ems) exercise to improve the quality of life (qlq) of patients with serious chronic disease. an improvement of qlq results from an increase in muscle mass and strength, thereby increasing physical activity, physical capability as well as tolerance to and applicability of therapy. in the course of a 3-months intervention study the efficacy of a combined german-guidelines-recommended protein-rich nutritional therapy with an innovative exercise therapy will be documented for patients with chronic liver disease. an effective stopping of the progress of muscle wasting or even increase of muscle mass, strength and function in the patients of the trial would benefit each patient and his family individually, since it could mean a considerable improvement in his qlq and tolerability of therapeutical treatment.

Eligibility criteria:
inclusion criteria: • patients with chronic liver disease in curative or palliative treatment exclusion criteria: * healthy persons or patients under age * pregnancy, lactation, * psychological disorders, epilepsy, sever neurological disorders * participation in other exercise- or nutrition studies within the last 6 months * acute cardiovascular disease * rheuma * intake of anabolic drugs, * skin injuries in the area of electrode placements * electronic implants (defibrillator, pacemaker) * persons in mental hospitals by order of authorities or jurisdiction