Kornimate/medical-research-clean huggingface dataset:
monitoring of intubation and ventilation during resuscitation

Conditions: Cardiac Arrest

Summary: airway control and ventilation is vital during cardiopulmonary resuscitation (cpr) in cardiac arrest. endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized placements of the tube in the esophagus instead of in the airway out-of-hospital. this is lethal. there are no failproof technique for recognising such mistakes clinically in the cardiac arrest situation. changes on the air volume in the lungs with ventilation changes the impedance (resistance to alternating current) through the thorax. this impedance is already measured routinely by the defibrillators used during cpr. we propose that we can measure ventilation volumes and also discover failed intubations by monitoring this impedance during cpr with the possibility of giving feedback on both to the rescuers.

on the anesthesiologist manned ambulance in oslo ventilation volumes during cpr will be controlled with a ventilator, the tidal volume varied in random order between 500, 700 and 100 ml, and the volumes be measured continuously as will the impedance between the defibrillator electrodes. in case of failed cpr, the patient will be declared dead. thereafter the lungs will be ventilated with 700 ml followed by removal of the endotracheal tube, placement of an endotracheal tube in the esophagus and ventilation of this tube, again with monitoring of the impedance.

Eligibility criteria:
inclusion criteria: * cardiac arrest exclusion criteria: * \<18 years old trauma pregnancy

Keywords: cardiac arrest resuscitation ventilation impedance
docetaxel and s1 (ds) versus s1 and cisplatin (sp) in curatively resected stage iiib/iv gastric cancer

Conditions: Gastric Adenocarcinoma

Summary: docetaxel was the first drug that showed survival benefits when added to the cf regimen, but it was very toxic. docetaxel is also has a synergistic anti-cancer effect with s-1, in phase i/ii studies. the use of a docetaxel plus s-1 combination as first-line chemotherapy for advanced gastric cancer achieved response rates of 46\~56% and a median survival time of 14.0\~14.3 months. based upon this background, the aim of this study is to detect a significant increase in 3 year dfs of disease for the test group (ds) relative to the control group (sp).


Eligibility criteria:
inclusion criteria: * histologically proven, stage iiib/ iiic curatively resected gastric carcinoma * ecog performance status 0-1 * curatively resected advanced gastric cancer patients of stage iiib/iiic * d2 lymph node dissection with r0 surgery * signed informed consent exclusion criteria: * subjects with documented distant metastasis. * malabsorption syndrome or disease significantly affecting gastrointestinal function * patients with other uncontrolled systemic illness, e.g. infection, poorly controlled htn * history of other malignancy. subjects who have been disease-free for 5 years or subjects with successfully treated in situ carcinoma are eligible. * subjects with preoperative/adjuvant other cancer treatment, such as chemotherapy, immunotherapy and radiotherapy
pathophysiological characterization of the neuromuscular function of a population with multiple comorbidities suffering from chronic renal failure in pre-dialysis.

Conditions: Chronic Kidney Failure; Chronic Kidney Disease stage3; Chronic Kidney Disease, Stage 4 (Severe); Chronic Kidney Disease Stage 5; Fatigue

Summary: the evolution of chronic kidney disease (ckd) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis). this fatigue has many origins, and one of them probably stems from a deterioration of neuromuscular abilities. very few studies have examined the physiological aspects of neuromuscular fatigue in pre-dialysis patients, and shedding light on potential deficits at this level would allow safe and efficient implementation of adapted physical activity programs. our study aims to characterize the pathophysiology of neuromuscular capabilities in chronic advanced renal failure in pre-dialysis patients.


Eligibility criteria:
inclusion criteria: * adult patients (age\> 18 years) who have signed the informed consent form * social security coverage * for patients in the chronic kidney disease group: glomerular filtration rate less than 60 ml/min of creatinine for more than three months exclusion criteria: * dermatological conditions of the upper limbs which would contra-indicate electromyographic electrodes being positioned * gestating women * patients with known neuromuscular conditions * patients with dementia * patients with acute heart failure * patients with a history of surgery of the evaluated limb * patients included in an interventional study involving administration of treatments other than routine care * for the patients in the chronic kidney disease group: patients currently undergoing dialysis or in a pre-dialysis program (e.g. with a dialysis fistula already in place).

Keywords: chronic kidney failure fatigue adapted physical activity
yoga intervention to improve pediatric cancer patients' sleep & life quality and parents' well-being

Conditions: Neoplasms

Summary: the proposed project will examine feasibility and preliminary efficacy of a yoga intervention in the pediatric oncology unit at connecticut children's medical center (ccmc) and includes two parts: (1) a survey of children and parents regarding preferences (e.g., convenient days/times), experiences and expectations regarding yoga (including barriers and positive expectancies) and (2) an eight week clinical trial of a yoga intervention in 10 pairs of children and parents.

the specific aims and hypotheses for this seed grant are to collect and assess data on: aim 1 feasibility - perceived barriers/solutions, interest and accrual rates, attendance per session, participant retention, evidence of institutional support and resource commitment hypothesis 1: a yoga intervention is feasible among pediatric oncology patients and their parents; (2) preliminary efficacy - including effect sizes for calculating power hypothesis 2a: a yoga intervention improves pediatric oncology patients' fatigue, qol, and sleep. hypothesis 2b: a yoga intervention improves parental qol and caregiver burden. we will be using the following questionnaires and scales to help answer the quesitons related to the hypotheses and aims: pedsql 4.0 pedsql 3.0 cancer module the fatigue scale sleepdiary actigraphy data. child home yoga practice diary satisfaction survey questionnaires noted below are given only to the parents: sf-12 zarit caregiver burden index yoga satisfaction survey study participants will have 4 yoga sessions and the questionnaires and surveys are done prior to the first yoga session and after the last yoga session. the yoga sessions are created with both the study participant and a certified yoga instructor. the patients are given the yoga routine to practice at home at their leisure.

Eligibility criteria:
inclusion criteria: * parents and children (ages 8-18) undergoing treatment (chemotherapy and/or radiation therapy) for cancer. * cancer diagnosis, between the ages of 8-18 year, english speaking, and medically cleared to participate in yoga. * parents will be eligible if they are over 18 years old, english speaking, and physically able to participate in yoga. exclusion criteria: * children and parents not meeting inclusion criteria
effect of heatwave over glycemic control in patients with t1d

Conditions: Type 1 Diabetes

Summary: observational study about effect of the greatest spanish heatwave over glycemic contro in adult patients with type 1 diabetes mellitus.

cross-sectional retrospective analysis of all patients with t1d in castilla-la mancha (south-central spanish region) using intermittently scanned continuous glucose monitoring (iscgm). glycometric data obtained through deidentified downloads from iscgm´s webpage. primary outcome was time in range (tir) 3.0-10 mmol/l (70-180 mg/d) change after the heatwave. data analysis is conducted using spss (chicago, il) statistics software. results are presented as mean ± sd values or percentages. a paired student's t-test or a wilcoxon signed-rank test were used for the analysis of differences. comparisons between proportions were analyzed using a chi-squared test. a p value \< 0.05 was considered statistically significant. the protocol was approved by the reference castilla-la mancha public health institute ethic committee.

Eligibility criteria:
inclusion criteria: * type 1 diabetes * older than 18 years old * using intermittently scanned continuous glucose monitoring (iscgm) * paired active iscgm data from the heatwave period and two consecutive weeks exclusion criteria: * younger than 18 years old * not using intermittently scanned continuous glucose monitoring * not having active paired iscgm data from the analyzed periods

Keywords: diabetes type 1 diabetes
early treatment of skeletal anterior open bite by two appliances

Conditions: Open Bite

Summary: open bite is a common dentoalveolar component of the facial pattern of the excessive vertical dimension patients that is also known as the gaping angle face pattern.it is a deformation in the vertical relationship between the upper and the lower dental arches that is characterized by the loss of contact between the opposite dental segments.

an open bite develops as a result of the interaction of many etiologic factors, both hereditary and environmental. prolonged sucking habits and hyper-divergent facial characteristics are significant risk factors for an anterior open bite in the mixed dentition. abnormal tongue posture (frequently associated with enlarged adenoids or tonsils) and tongue thrust also can be involved in the establishment of alveolar and skeletal discrepancies concurrent with vertical problems two types of an open bite are recognized in this profession: (1) dentoalveolar open bite: the abnormality formalities aspects limiting in the dental and alveolar region, usually associated with abnormal function habits as the thumb sucking and (2) skeletal open bite: that's associated with an over high of the lower facial vertical dimension and a large plane angle of the lower jaw. open bites associated with excessive vertical skeletal dimensions are difficult to treat and tend to relapse the investigators must be recognized between the dentoalveolar open bite and the open bite caused by formalities disorders and the position disorders of the upper or the lower jaw or both. dental an open bite can be corrected by itself if the treatment was beginning early and it's responding easley to the mechanical treatment methods and the functional treatment approaches that depending on the muscular activity

Eligibility criteria:
inclusion criteria: * anterior open bite (2-10) mm. * skeletal class i or ii malocclusion. * mp-sn angle ranged between (33-45) degrees. * mm angle ranged between (27-37) degrees. * age between 7.5-10.5 years. exclusion criteria: * patients who had an old orthodontic treatment * people with a syndrome or congenital deformity
low field magnetic stimulation treatment for bipolar depression

Conditions: Bipolar Depression; Bipolar Disorder; Depression

Summary: individuals with bipolar depression who had a particular kind of brain imaging reported improved mood after the imaging. this effect may be linked to the changing magnetic fields used during these magnetic resonance imaging studies. the current studies are designed to further explore the important parameters of this effect and to clarify the degree and duration of the mood effects.

an initial study using proton echo-planar magnetic resonance spectroscopic imaging (ep-mrsi) in bipolar depressed individuals was associated with reports of improved mood. these studies employed oscillating magnetic fields similar to those used in functional mri (fmri), but which differ from the usual fmri scan in field direction, waveform frequency, and strength. as the abbreviation ep-mrsi is used to describe several relatively common mr sequences, the specific potential clinical procedure being used is referred to as low field magnetic stimulation or lfms. following these initial results, investigators are conducting studies to determine the critical variables in both subjects and treatment for optimal response. studies are also underway to characterize the response of specific depression symptoms, the degree of response, and the duration of response.

Eligibility criteria:
inclusion criteria: * primary diagnosis of bipolar disorder. * current depression. exclusion criteria: * contraindication for mri due to metal in eyes/head * claustrophobia. * inability to lie flat. * history of brain injury.

Keywords: non-pharmaceutical alternative imaging magnetic resonance imaging low field magnetic stimulation bipolar disorder depression bipolar depression
open label, dose-regimen study evaluating etanercept 50 mg once-weekly in japanese subjects with ra

Conditions: Arthritis, Rheumatoid

Summary: the primary purpose of this study is to evaluate the safety and efficacy of a once-weekly dose of etanercept for rheumatoid arthritis. currently, patients in japan can only use 25 mg etanercept two times a week. if a once-a-week regimen of 50 mg is approved, this would be more convenient for most patients. this once-weekly regimen is used in countries outside of japan.


Eligibility criteria:
main inclusion criteria: * subjects of japanese ancestry and living in japan. * subjects who are receiving the approved dose of 25 mg etanercept biw for at least 6 months and have stable disease activity, as determined by investigator's judgment for 3 months before test articles administration. * subjects who have mildly active rheumatoid arthritis as demonstrated by 5 swollen joints and 5 tender/painful joints. main exclusion criteria: * prior treatment with disease modifying anti-rheumatic drugs (dmards) and/or methotrexate (mtx) within 6 months of the baseline visit. * subjects considered being in disease remission, per investigator's judgment. * received other biological drugs, rituximab, anti-cd-4 agents, or diphtheria interleukin-2 fusion protein (dab-il-2) within 6 months prior to baseline.
segudiab study: evaluation of safety in the diabetic patients

Conditions: Diabetes Mellitus

Summary: the safety in the diabetic patient refer so much to the accuracy of the treatment and to the handling of the diabetic in security topics. therefore, is not only an economic question, but a more global concept that means to receive an accurate sanitary attention in line with the available evidences nowadays. objective: to analyse if a brief intervention educative on the primary care professionals is followed of an improvement in the safety of the diabetic patients. methods: cluster clinical trial, completely in primary care, on 10 basic health areas (bha) with a random distribution of the educative intervention to realize on the sanitary professionals (5 intervention/5 control). the intervention is an educative system on adults, brief (6 hours) but with periodic reminders. to improve his skills and attitudes for the diabetics. the group control follows his usual clinical practice on the diabetics. the participation was voluntary. the centres have been matched, being comparable in population and other characteristics, except the specific intervention; ranging between the 6-8% the prevalence observed of type 2 diabetes (t2d) in all the cases. finally, we selected only between 45 until 75 years old as operative age group of the 45 until the 75 years like operative aim. inclusion criteria: t2d or t1d with age comprised between 45 and 75 years; recorded in the informatic software for primary care. exclusion criteria: serious or terminal illness or patients controlled exclusively by specialists.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of diabetes * aged between 45 and 75 years exclusion criteria: * no data in informatic system * severe illness * controlled only by specialists

Keywords: patient's safety diabetes mellitus public health for professionals safety public health
platelet rich plasma for knee osteoarthritis

Conditions: Osteo Arthritis Knee; Platelet-rich Plasma

Summary: this study aimed to analyze the effect of platelet-rich plasma (prp) on knee osteoarthritis. eligible patients will undertake arthroscopic knee surgery plus intraoperative prp and also receive second look surgery and intraoperative biopsy.

osteoarthritis is a chronic disease defined by progressive degradation of the joint as well as loss of cartilage on joint surfaces. the degeneration that occurs in the joint leads to changes in the catabolic and anabolic activity of chondrocytes. osteoarthritis may induce pain, stiffness and limitation in range of motion of the joint and also may impact the quality of life. platelet-rich plasma (prp) is a fraction of plasma that contains platelets and multiple growth factors concentrated at high level. because activated platelets have the potential to release growth factors, prp has been clinically used to accelerate wound healing and tissue regeneration in orthopedic and oral surgery. although several studies have assessed the effects of prp on knee osteoarthritis, a higher level of evidence has not been provided. this study aimed to analyze the effect of prp on knee osteoarthritis. after performing arthroscopic knee surgery plus intraoperative prp in eligible patients, a second look arthroscopic surgery with intraoperative biopsy will be arranged 6 months later. pre- and post-operative imaging and clinical outcomes will also be compared.

Eligibility criteria:
inclusion criteria: * age between 30 and 70 years * with diagnosis of osteoarthritis, grade ii\~grade iv, ii-iii medial compartment exclusion criteria: * lateral compartment and patellofemoral joint osteoarthritis * with prior history of knee surgery * severe varus deformity * with current or prior history of traum or infection at the knee * with current or prior history of cancer * with current or prior history of hematological disease * pregnancy * patients who will not cooperate with one-year followup

Keywords: platelet-rich plasma osteoarthritis knee
the effects of physical training and glp-1 receptor agonist liraglutide treatment in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the objective of this study is to investigate the effects of physical training in patients with type 2 diabetes during treatment with the glp-1 receptor agonist liraglutide (victoza®) in a 16-weeks double-blinded, randomized placebo-controlled clinical trial. hypothesis: physical training leads to better metabolic control in type 2 diabetic patients when training is combined with liraglutide (victoza®) treatment.


Eligibility criteria:
inclusion criteria: * informed oral and written consent * diagnosed with type 2 diabetes according to the criteria of the who * hba1c: 7-11% (doing treatment with diet and/or metformin) * age \>18 years * bmi \>25 kg/m2 \<40 kg/m2 * negative islet cell antibodies (ica) and glutamate decarboxylase 65 (gad- 65) autoantibodies exclusion criteria: * females of child bearing potential who are pregnant, breast-feeding or have intention of becoming pregnant or are not using adequate contraceptive measures. * subjects treated with sulfonylureas, dipeptidyl peptidase 4 (dpp-4) inhibitors, insulin or glitazones * ongoing abuse of alcohol or narcotics * impaired hepatic function (liver transaminases \>2 times upper normal limit) * impaired renal function (se-creatinine \>150μm and/or albuminuria) * cardiac problems defined as decompensated heart failure (nyha class iii or iv), unstable angina pectoris and/or myocardial infarction within the last 12 months * uncontrolled hypertension (systolic blood pressure \>180 mmhg, diastolic blood pressure \>100 mmhg) * anaemia * any condition that the investigators feels would interfere with trial participation * receiving any investigational drug within the last 3 months

Keywords: glp-1 training exercise type 2 diabetes
pregnancy complications - a probiotic interventional study

Conditions: Preeclampsia; Preterm Birth

Summary: investigators hypothesize that a) probiotics decrease the overall inflammatory state in the pregnant woman, especially in women with high risk pregnancies.

the main of the project is to determine if dietary supplementation intake of probiotics are associated with a decreased inflammatory response in pregnant women, especially those with a history of previous preterm birth or preeclampsia, in a randomized clinical trial. investigators also want to further investigate the relationship between intake of probiotics and the degree of inflammation in different compartments during pregnancy to see how the probiotic components affect the inflammatory state in the women.

Eligibility criteria:
inclusion criteria: * maternal age \> or = 18 y * singleton pregnancy * nulli or multiparous without maternal intercurrent diseases or pregnant women with a history of spontaneous preterm delivery or pregnant women with a history of preeclampsia. exclusion criteria * multiple pregnancy * gestational age \> 17+6 weeks at first visit * chronic intermittent diseases (e.g. diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis, chron disease, ulcerative colitis) * uterus malformations * immunomodulatory medication * hormonal treatment (e.g. crinone, progesterone) * subject disagrees to stop intake of other products containing probiotics during study time. * subject is unable to provide written informed consent

Keywords: probiotics inflammation immunological response preterm birth preeclampsia