Kornimate/medical-research-clean huggingface dataset:
efficacy, safety and pharmacokinetics of oral lde225 in treatment of patients with nevoid basal cell carcinoma syndrome (nbccs)

Conditions: Basal Cell Carcinoma; Gorlin Syndrome; Nevoid Basal Cell Carcinoma Syndrome

Summary: this was a phase ii, double-blind, randomized, proof-of-concept, dose-ranging trial evaluating the efficacy, safety and pharmacokinetics of oral lde225 in treatment of adult patients with nbccs. this was an exploratory study designed to demonstrate preliminary efficacy of lde225 in this indication. this study included a screening period of approximately 4 weeks, treatment period duration of 12 weeks with initial follow-up of approximately 6-8 weeks followed by a long-term follow-up period.


Eligibility criteria:
inclusion criteria: * patients with multiple basal cell carcinomas (at least two) and typical presentation of nbccs. * female patients must be women of non-childbearing potential (woncbp). exclusion criteria: * use of any topical treatment to treat bccs, including prescription and over the counter in the 4 weeks prior to first dose of study drug. * use of photodynamic therapy (pdt), radiation or systemic treatment known to affect bccs or neoplasm in the 12 weeks prior to first dose of study drug. * patients receiving medications that are recognized to cause rhabdomyolysis or patients with a prior history of rhabdomyolysis. * patients with a histologically confirmed diagnosis of locally advanced or metastatic bcc. other protocol-defined inclusion/exclusion criteria may apply

Keywords: basal cell carcinoma gorlin syndrome, gorlin-goltz syndrome, basal cell nevus syndrome, nevoid basal cell carcinoma syndrome, basal cell carcinoma nevus syndrome smo inhibitor, hedgehog pathway inhibitor bccs
effect of a dual-task intervention program on physical and cognitive function

Conditions: Functional Movement Disorder; Fragility

Summary: aim: to compare the effects of single-task (st) and dual-task (dt) training on physical and cognitive function in institutionalized older adults in 1 month. methods: participants were assigned randomly into two groups, st (multicomponent physical exercise) and dt training (multicomponent physical exercise + cognitive tasks). both groups performed the exercise three times per week for 1 month. short physical performance battery (sppb), handgrip strength, barthel index and montreal cognitive assessment (moca) were used to assess physical and cognitive performance, respectively. variables were measured at the beginning (v1),at the end of the exercise (v2), as well as one month later (v3). paired student's t-test and lineal logistic regressions models were used to explore the effect of the exercise interventions.


Eligibility criteria:
inclusion criteria: * institutionalized older people between 65 and 75 * mild to moderate cognitive impairment exclusion criteria: * acute or chronic pathologies that prevent exercise

Keywords: dual task exercise institutionalized physical function
effectiveness of the cognitive orientation to daily occupational performance (co-op)

Conditions: Stroke

Summary: the goal of this clinical study is to examine the effectiveness of the cognitive orientation to daily occupational performance (co-op) in adults (45+) with accuired brain injury when applied in danish rehabilitation context. the primary research question is: what is the effectiveness of the co-op approach on improvement of performance of daily activities (adl) and quality of life compared to usual rehabilitation practice. participants in the intervention group will recieve the co-op intervention as part of their rehabilitation in the following phases: initial phase: goalsetting is mandatory and based on the participant's prioritized adl performance issues identified in their baseline copm. education phase: individual education in the metacognitive goal-plan-do-check strategy. training phase: co-op training that involves repetitive use of the goal-plan-do-check for problem solving and skill acquisition. the therapist employs dynamic performance analysis and guided discovery to help participants understand performance issues and formulate plans for achieving their goals. participants then execute and evaluate these plans, with a focus on developing domain-specific cognitive strategies. the therapist actively encourages generalization and transfer of skills. homework is mandatory. participants in the control group will recieve usual rehabilitation practice in the following phases: initial phase: goalsetting is optional and may be based on previous assessment or on a conversation with the participant. training phase: different approaches may be taken such as observation and practice of activities or consultation about performance issues and how participants may deal with them. the therapist may guide the participant's performance verbally, physically or trough picture materials. homework may be included.


Eligibility criteria:
inclusion criteria: * stroke or traumatic brain injury * reffered from acute hospital or specialized rehabilitation units to municipal rehabilitation * having at least on adl performance issue exclusion criteria: * dementia, psychotic diagnoses, commotio, brain tumor or degenerative neurological conditions. * alkohol or drug abuse * not speeking or understanding danish

Keywords: stroke rehabilitation co-op occupational therapy
evaluating patients with eye allergies and determining if there are also dry eyes

Conditions: Dry Eyes; Allergic Conjunctivitis

Summary: evaluating the percentage of patients that suffer from eye allergies and determining whether they also have dry eyes.


Eligibility criteria:
inclusion criteria: * ability to give informed consent * males and females at least 18 years of age * personal history of allergic disorders including but not limited to allergic conjunctivitis, allergic rhinitis, contact dermatitis and other eczema, and asthma * diagnosis of allergic conjunctivitis * presence of any of the following signs including conjunctival redness and papillae, chemosis, red edematous eyelids, reduced tear clearance, reduced tbut, vital staining, stringy discharge, and/or symptoms including ocular itching, burning and tearing, runny nose or itchy throat exclusion criteria: * active ocular or systemic infection * history of ocular infection within past 6 months * presence of punctal plugs * recent ocular surgery within past 6 months * current use of chemotherapeutic agents * presence of ocular trauma * inability to give informed consent * women who are pregnant, nursing or lactating

Keywords: burning dryness itching blurry vision
home based exercise in preventing fall and improving balance in older people

Conditions: Patient Fall; Muscle Balance; Fear of Falling; Quality of Life

Summary: prior studies have shown multifaceted falls prevention program with home-based exercise reduced falls significantly in the community setting. the otago exercise program has been tested in four separated controlled trials of community living people in new zealand. falls were the main outcome in each trail and were defined as "unintentionally coming to rest on the ground, floor or other lower level". not only this combination strengthening and balance training exercise could reduce fall but also could benefit in cost-effectiveness for fall prevention and decrease mortality in those 80 and older. however the limitation of otago exercise program is that the program was needed to be trained by skill nurses or physical therapists. there are 17 steps levels to adhere the program. as some studies have shown that fall prevention program adherence could be as low as 10-40%. in thailand the lack of medical staffs are continued the problem in the community. therefore to establish fall prevention guideline that will be suitable and translated into the real setting, this study is aimed to test the effectiveness of simple program home-based exercise comparing to non-simple program home based exercise in preventing fall and improve muscle strength and balance dysfunction in older people with mild to moderate balance dysfunction. the method is the randomized controlled trails.


Eligibility criteria:
inclusion criteria: 1. thai elderly aged 65 years or older 2. able to communicate and follow the home-based exercise programme 3. mild to moderate balance dysfunctions as followings: * functional reach test score less than 26 cm. * five time sit to stand test more than 17.9 seconds * able to walk independently or walk with only single cane 4. non diagnosed with moderate to severe dementia or depression 5. non diagnosed with parkinson disease 6. non diagnosed with cerebrovascular disease with less than grade 4 hemiparesis. 7. non diagnosed with acute arthritis or recent diagnosed within 6 months. 8. informed and consent to participate in the study 9. not participate in regular tai-chi or yoga exercise training. exclusion criteria: 1. participants would like to withdraw from the study. 2. severe injury occured after following simple designed exercise program eg. tendon injuries.
the effects of viscoelastometry guided resuscitation during burn excision on post resuscitation infections

Conditions: Burns

Summary: this is a randomized controlled trial to compare viscoelastometric (ve) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and inflammatory mediators, and how these strategies affect post resuscitation infections.

this is an open labeled study as the viscoelastometric (ve) guided transfusion will be based on the visible ve results. subjects will be randomized to receive either the standard practice transfusion or ve guided transfusion. blood samples, standard demographic information, and routine laboratory data will be collected on all subjects in the burn icu (bicu) enrolled in the study. ve analysis will be performed on all subjects immediately prior to the burn excision, and approximately every 40 minutes while the patient is in the operating room (or) as well as on arrival to the bicu and every 8 hours depending on their need for ongoing transfusion for a maximum of 24 hours. as our intervention, only the ve based transfusion group will have access to the ve analysis at time of transfusion. the ve results will be used at the discretion of the treating physician based on the ve guided transfusion algorithm. outcomes include the number and timing of blood products transfused from the time of randomization to 24 hours post randomization and the presence of any 30 day post-transfusion infections.

Eligibility criteria:
inclusion criteria: * burn patients admitted to parkland hospital with total burn surface area (tbsa) greater than 20% exclusion criteria: * patients admitted to parkland hospital for reasons other than burns or for burns less than or equal to 20%
electro- hemodynamic activity in children: combined analysis by video -eeg spectroscopy and near-infrared (nirs )

Conditions: Epilepsy

Summary: epilepsy in children is a major public health issue. it is the first neurological disease of the child.

epilepsy in children is a major public health issue. it is the first neurological disease of the child. the specific incidence of epilepsy rates were highest during the first year of life, between 75,105 and 250,105 hab.an hab. year and remain high in the age group between 0 and 10 years. epilepsies predictions are varied. they can be spontaneously benign, drug-, chemically dependent or drug-resistant. these, refractory epilepsies, represent 20% of epilepsy as a child and adolescent than adult is about 1200 children and 1200 adults picardy. the validation of non-invasive investigative tools is becoming a necessity in the management of drug-resistant epilepsies especially when a surgical decision is envisaged. the aftermath (motor, cognitive, sensory) appear to rule early; but they are sometimes limited to learning deficits detected later in the school curriculum. the investigators know that defects in neuronal electrical activity (eg critical discharges) induce a metabolic response and conversely metabolic disturbances can cause abnormal electrical activity. it is therefore important to have tools to better characterize the interactions between these two mechanisms to better understand brain function in the brain during development and during pathological situations. the investigators lack quantitative criteria regarding the impact of crises on the metabolic activity and thus predictive criteria consequences of crises on brain function. the deleterious hazard must be considered at all ages in both structures to causing seizures than in those where the crisis spread. the functional characterization, electrical, metabolic and anatomic pathology of these networks is necessary and contributes to a better understanding of physiological and pathological brain function, and helps to define the most appropriate treatment strategy. about childhood epilepsy, analysis of the eeg allows in 75% of cases to find predictive patterns characteristic of becoming. however in 25% of cases, we lack predictive objective criteria. this highlights the importance of developing analysis tools for more accurate and efficient brain function and to improve the management and evaluation of the prognosis of these children.

Eligibility criteria:
inclusion criteria: - any child 0-16 years with partial epilepsy and / or interictal spikes located on the standard eeg recordings. exclusion criteria: * all children with severe congenital malformation * any refusal of a parent * any child with generalized epilepsy or diffuse interictal spikes * any child with a serious deterioration in the general condition and vital functions * any child with dermatitis of the face or scalp

Keywords: newborn infant child eeg nirs
lapas study: insulin glargine in type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: the objective of this protocol is to confirm the efficacy and safety profile of lantus in every day medical practice, in type 2 diabetic patients, have been treated with any other insulin but who did not reach the target of a1c = 7%.


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus, * having been treated with any other insulin, but who did not reach the target of a1c=7%. * ability and willingness to perform self monitoring blood glucose measurement exclusion criteria: * will follow the prescribing information (summary of product characteristics). the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
determination of health care needs of elderly individuals according to the omaha classification system and investigation of the effects of implemented nursing interventions on healthy lifestyle behaviors and quality of life

Conditions: Nurse-Patient Relations

Summary: as in the whole world, there is an increase in the elderly population in the trnc. however, no systematic care is provided for the registration and follow-up of elderly individuals. in this study, it is aimed to determine the health care needs of the elderly with a systematic method with the omaha classification system (oss), which is used in the home care system in the world and in turkey, and to examine the effectiveness of the nursing interventions applied according to the health care needs of the elderly people. with this method, it is thought that the continuity of monitoring and monitoring the health care needs of elderly individuals with a systematic approach will be ensured.

as in the whole world, there is an increase in the elderly population in the trnc. however, no systematic care is provided for the registration and follow-up of elderly individuals. in this study, it is aimed to determine the health care needs of the elderly with a systematic method with the omaha classification system (oss), which is used in the home care system in the world and in turkey, and to examine the effectiveness of the nursing interventions applied according to the health care needs of the elderly people. with this method, it is thought that the continuity of monitoring and monitoring the health care needs of elderly individuals with a systematic approach will be ensured. thus, it will be ensured that nursing interventions for the health care needs of elderly individuals are planned and implemented, and the nursing interventions applied for the field of health behaviors they live will be planned. in line with the data to be obtained as a result of the research, it is aimed to establish a system that will provide an opportunity to provide quality nursing care aimed at improving the health of the elderly, which is an important area of public health nurses in the trnc.

Eligibility criteria:
inclusion criteria: * 65 years old self care exclusion criteria: * comminication barrier mentally handicapped

Keywords: health, elderly,nurse
conducting active surveillance without prostate biopsy for patients with low-risk suspected prostate cancer

Conditions: Prostate Cancer

Summary: the goal of this observational study is to evaluate the role of the ustc diagnostic model in risk-adaptive strategies for biopsy decision-making in patients with low-risk suspected prostate cancer in order to reduce unnecessary biopsy. based on the ustc diagnostic model (website: https://ustcprostatecancerprediction.shinyapps.io/dynnomapp/) and serum psa levels, patients with low-risk suspected prostate cancer are enrolled and received active surveillance rather than biopsy. the main questions to be answered is: • the safety and feasibility of conducting biopsy-free active monitoring in patients with low-risk suspected prostate cancer accessed by the ustc diagnostic model and serum psa levels. participants will be required to undergo serum psa testing every 3 months, mpmri testing every 6 months, and reassessment of the probability of developing prostate cancer using the ustc model every 3 months. patients who do not meet the inclusion criteria and are at increased risk will no longer receive active surveillance and will be advised to undergo biopsy. dynamic changes in pi-rads score and biopsy results will also be recorded.


Eligibility criteria:
inclusion criteria: 1. patients with clinically suspected pca have indications for prostate biopsy; 2. complete serum psa testing and mpmri examination in the outpatient department; 3. 4 ng/ml ≤ serum total psa ≤10 ng/ml; 4. the probability of prostate cancer calculated by ustc diagnostic models is less than 0.05; 5. there is no family history of prostate cancer and no history of other malignant tumors. exclusion criteria: 1. the patient has previous history of prostate biopsy; 2. lack of complete clinical information, such as failure to perform mpmri; 3. patients with serum total psa \ 10ng/ml. 4. according to ustc diagnostic model, the probability of prostate cancer is equal or more than 0.05.

Keywords: prostate cancer prostate biospy mpmri prostate specific antigen density diagnostic model active surveillance
evaluation of halitosis after treatment with photodynamic therapy associated with periodontal treatment

Conditions: Halitosis

Summary: the aim of this randomized, controlled clinical trial was to treat oral halitosis in healthy adults with photodynamic therapy associated with periodontal treatment and follow them up for 3 months. the participants with halitosis will be randomized into two groups: g1-treatment with photodynamic therapy or g2-cleaning of the tongue with a tongue scraper . halitosis were evaluated measuring volatile sulfur compounds using gas chromatography after the treatments, a second evaluation will be performed, along with a microbiological analysis (qpcr) for the identification of the bacteria t. denticola

halitosis is an unpleasant odor that emanating from the mouth. a recent metanalysis shows worldwide trend towards a rise in halitosis prevalence. studies show halitosis returns in a week after treatment with photodynamic therapy (pdt). probably, bacteria residing in the periodontal sulcus could recolonize the dorsum of the tongue. to date, there are no study in adult population that associate halitosis and periodontal treatment with follow-up evaluation. the aim of this randomized, controlled clinical trial was to treat oral halitosis in healthy adults with photodynamic therapy associated with periodontal treatment and follow them up for 3 months. the participants (n=40) with halitosis will be randomized into two groups: g1-treatment with photodynamic therapy (n = 20) or g2-cleaning of the tongue with a tongue scraper (n = 20). halitosis were evaluated measuring volatile sulfur compounds using gas chromatography after the treatments, a second evaluation will be performed, along with a microbiological analysis (qpcr) for the identification of the bacteria t. denticola. the evaluation of halitosis and the microbiological analysis will be repeated. after that, patients will receive periodontal treatment. the participants will return after 1 week and three months for an additional evaluation. quality of life will be measured by oral health impact profile (ohip-14) comparisons will be made with anova test, with the level of significance of 5 %. this protocol will determine the effectiveness of phototherapy regarding the reduction of halitosis in adults.

Eligibility criteria:
inclusion criteria: * both genders * with at least 10 teeth * periodontal screening and recording (psr) 0, 1 or 2 * without any changes in the anatomy of the back of the tongue (geographical or fissured tongue) * positive halitosis (sh2 level higher than 112 ppb). exclusion criteria: * smokers * ex-smokers for less than 5 years * patients with hypersensitivity to the photosensitizer.

Keywords: photodynamic therapy periodontal disease randomized controlled clinical study
a study to evaluate routine chest tube management after minimally invasive lung surgery

Conditions: Lung Cancer

Summary: chest tubes are routinely required after surgical procedures for lung cancer. this device is a flexible plastic tube that is inserted through the chest wall to remove air or fluid from around your lungs after surgery for lung cancer. there are two general strategies associated with the clinical management of chest tubes, active and passive suction. if suction is compared to driving a car, active suction is similar to pressing the gas pedal while passive suction is like letting your car move on its own. the suction approach taken by surgeons largely depends on how they were trained and some personal biases and beliefs. however there is no general consensus about which chest tube management strategy is best. this research aims to compare two settings on a digital drainage system, a low suction (ls) mode - passive suction - and standard suction (ss) mode - active suction. from the data collected, the researchers will analyze whether ls or ss will lead to a better recovery after surgery.


Eligibility criteria:
inclusion criteria: 1. patients who are undergoing lobectomy or segmentectomy 2. patients undergoing wedge resection to diagnose, or as definitive therapy for a lung nodule/cancer. 3. able to understand and sign consent exclusion criteria: 1. patients undergoing pneumonectomy or bilobectomy 2. patients undergoing resection for inflammatory conditions such as aspergillosis 3. patients undergoing diagnostic wedge resection for interstitial lung disease 4. patients undergoing redo-vats or thoracotomy on the same side as current planned resection 5. patients found to have a "frozen chest" at the time of surgery, requiring extensive adhesiolysis, 6. patients who are discovered to have metastatic disease during the operation, so that resection is no longer indicated. 7. patients where a clinical decision to place more than one chest-tube is made