Kornimate/medical-research-clean huggingface dataset:
objective measurements of the opacification of the lens after vitrectomy

Conditions: Vitrectomy; Cataract

Summary: cataract is the opacification of the lens. usually cataract occurs slowly, causing progressive vision loss over several months or years. in ophthalmic clinical practice, repeated objective quantitative measurements of lens opacity may be necessary to document its progression and support a surgical indication. the subjective methods of evaluating the opacification of the lens have limitations, in particular due to the lack of reproducibility between observers. thus, innovative objective techniques with precise and reproducible cataract classification results have been developed, such as the objective scatter index (osi) on the optical quality analysis system (oqas), visiometrics sl in 2010 and, more recently, average lens density (ald) on the iolmaster® 700 device. cataract is diagnosed as mature when the osi is ≥ 2 and / or when the ald is ≥ 74 pixel units. vitrectomy is a surgery of the posterior segment of the eye indicated for retinal detachment, epimacular membranes, macular holes, vitreous hemorrhage. the incidence of post-vitrectomy cataract varies among studies, and the methodology is often retrospective. age has already been identified as a risk factor for progression since in a study of 28 eyes of patients under 50 years old, only 7% developed cataracts secondarily, compared to 79% in the 'over 50' group. to date, there is no prospective study describing the progression kinetics of lens opacification according to precise and reproducible quantitative objective criteria in patients treated by vitrectomy. it also involves confirming the age and preoperative lens status as a risk factor for postoperative cataract progression.


Eligibility criteria:
inclusion criteria: * patient over 18 years old * indication for unilateral 3-way vitrectomy for retinal detachment, macular hole, epiretinal membrane, vitreous hemorrhage * bilateral phakic patient exclusion criteria: * vitrectomy combined with cataract surgery * pregnant or breastfeeding woman

Keywords: objective scatter index (osi) optical quality analysis system (oqas) average lens density (ald) iolmaster® 700
validation of a novel oscillometric-based algorithm for determination of the ankle-brachial index

Conditions: Peripheral Arterial Disease

Summary: peripheral arterial disease (pad) is a highly prevalent medical condition. patients with pad are usually diagnosed on the basis of the ankle-brachial index. the ankle-brachial index is the ratio of ankle pressure to arm pressure after measurement of blood pressures in the arms and legs using a doppler device. the need for dedicated equipment and trained personnel, along with the time required to perform the test, have been identified as barriers to widespread implementation of ankle-brachial index screening. the use of automated oscillometric devices for blood pressure measurement has been applied to leg pressure measurement and determination of the ankle-brachial index with variable success. it will be beneficial to investigate a reliable oscillometric-based procedure that can accurately measure leg pressures for the ankle-brachial index across the entire spectrum of pad severity. in a previous pilot study completed in 2009 (irb 08-823), the investigators gathered data from n=60 subjects which allowed for mathematical analysis of oscillometric waveforms derived from the lower extremities as compared to doppler-based measurements of blood pressure. we used signal processing analysis and regression techniques to develop a two-step algorithm which will allow for accurate interpretation of oscillometric waveforms in normal/mild vs. moderate/severely diseased limb and accurate calculation of ankle pressure across the spectrum of peripheral artery disease severity. this proposed project will validate this novel oscillometric abi algorithm in a population of patients who have been identified as at risk for pad and for whom screening abi has been recommended by multiple professional organizations (aha/acc and american diabetes association). arm, ankle, and toe pressure measurements will be made in the supine position using doppler, oscillometric methods, and a photoplethysmographic sensor. the ankle-brachial index and toe-brachial index will be calculated.


Eligibility criteria:
inclusion criteria: * at least 70 years of age * at least 50 years of age with a history of diabetes mellitus or tobacco smoking (\>100 cigarettes in their lifetime) * ambulatory outpatient exclusion criteria: * unable to give informed consent * unable to lie supine for at least 15 minutes * known non-compressible vessels on prior laboratory studies (abi\>1.3 on either side)

Keywords: peripheral arterial vascular
investigation on risk factors of rheumatoid arthritis related interstitial lung disease

Conditions: Rheumatoid Arthritis Associated Interstitial Lung Disease

Summary: rheumatoid arthritis (ra) is one of the most common autoimmune diseases, characterized by chronic inflammatory bone and cartilage destruction. although treatment including anti-tumor necrosis factor (tnf) and interleukin-6 (il-6) receptor antibodies has been successful, only 20% to 30% of patients have achieved complete remission. interstitial lung disease (ild) is a common complication of rheumatoid arthritis (ra). approximately 5-10% of ra patients have clinically significant rheumatoid arthritis associated interstitial lung disease (ra-ild), with a mortality rate of 2-10 times that of ra-non ild patients. the median survival after diagnosis is between 3-8 years. although there are multiple biomarkers for ra-ild, such as anti citrullinated protein antibody (acpa), muc5b mutant gene, kl-6, etc., none of these biomarkers can reliably predict the disease and prognostic risk of ra-ild. therefore, improving the prediction of ra complicated with ild and exploring risk factors for the progression and prognosis of ra-ild can contribute to early diagnosis and treatment, and is of great significance in preventing ra lung injury and death. this study aims to screen differential serum biomarkers between ra patients and ra-ild patients through prospective cohort studies, to explore whether these differential serum biomarkers are a risk factor for ra patients complicated with ild, and whether they affect the clinical prognosis of ra-ild patients.


Eligibility criteria:
inclusion criteria: 1. diagnosis of rheumatoid arthritis patients based on the 2010 acr/eular ra classification criteria; 2. age ≥18 years; 3. interstitial lung disease was diagnosed by lung high resolution computed tomography (hrct) exclusion criteria: 1. age \<years; 2. being treated with urate-lowering medications; 3. other systemic/organ specific autoimmune diseases other than rheumatoid arthritis (such as sle, anca associated vasculitis, pss, ssc, myositis, etc.); 4.tumor, pulmonary tuberculosis, glomerular filtration rate less than 30ml/min/1.73m2
acne remission maintenance by weekend systemic isotretinoin

Conditions: Acne Vulgaris

Summary: the goal of this study is to learn if isotretinoin oral tablets as a weekend regimen are safe and effective to maintain freedom from acne lesions in young adults who have completed a full course of isotretinoin on daily basis and achieved total control of the acne activity.

three groups of adult acne patients will be given a full course of isotretinoin with a cumulative dose of 120-150 mg/kg weight in the 1st two groups, and till lesional clearance in the 3rd group with an additional month of maintenance. afterwards, the 1st group will use adapalene gel every other day for maintenance, the 2nd and 3rd groups will use weekend oral isotretinoin. patients will be followed for a year for reappearance of acne lesions, and safety of maintenance regimens. patients opinion will be also sought.

Eligibility criteria:
inclusion criteria: * adult patients (≥ 18 years) with moderate to severe facial acne, as per the investigator global assessment (iga) scale exclusion criteria: * patients on systemic acne medications in the past 3 months or topicals in the last month, pregnant or breastfeeding females, those with evidence of endocrine disturbances or using medications for comorbidities
study of autologous tumor lysate-pulsed d-cik combined with chemotherapy for gastric cancer

Conditions: Gastric Cancer; Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases

Summary: the purpose of this study is to evaluate the safety and efficacy of chemotherapy combined with autologous tumor lysate-pulsed dendritic with cytokine-induced killer cell (ag-d-cik) for gastric cancer.

40 patients with stage ⅰ～ⅲ gastric cancer,who had received surgery and kept their tumor tissue,will be randomly divided into group a（receive ag-d-cik treatment and chemotherapy) or group b（just receive chemotherapy),and the randomize ratio will be 1:1. patients in group a will receive 3 cycles of ag-d-cik treatment (every 1 months) and 4 cycles of chemotherapy (every 2 weeks).patients in group b will receive only 4 cycles chemotherapy（every 2 weeks).

Eligibility criteria:
inclusion criteria: * patients who can accept curative operations * 18\~80 years old * histologically confirmed with gastric cancer at stage ⅰ\~ⅲ * patients who can accept radical gastrectomy; * eastern cooperative oncology group (ecog) performance status was 0 - 1. exclusion criteria: * hemoglobin\<8.0 g/dl,white blood cell \<3 x 10\^9/l;platelet count \<75 x 10\^9/l; alt, ast, bun and cr more than normal limits on 3.0 times * known or suspected allergy to the investigational agent or any agent given in association with this trial * pregnant or lactating patients * known history of human immunodeficiency virus (hiv), hepatitis c virus (hcv) or treponemapallidun (tp) infection * patients who are suffering from serious autoimmune disease * patients who had used long time or are using immunosuppressant * patients who had active infection * patients who are suffering from serious organ dysfunction * patients who are suffering from other cancer * other situations that the researchers considered unsuitable for this study.

Keywords: gastric cancer d-cik autologous tumor lysate
electrical stimulation in peripheral arterial disease

Conditions: Peripheral Arterial Disease

Summary: the investigators wish to investigate the effects of neuromuscular stimulation on intermittent claudication.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of stable intermittent claudication (\>6 months) with confirmation by medical imaging * abpi\<0.9 * absolute walking distance \<500m exclusion criteria: * pregnancy * cardiac pacemaker * previous lower limb major amputation
safety and efficacy study of bimatoprost in the treatment of men with androgenic alopecia

Conditions: Alopecia; Alopecia, Androgenetic; Baldness

Summary: this study will evaluate the safety and efficacy of 3 doses of bimatoprost solution compared with vehicle and over-the-counter (otc) minoxidil 5% solution in men with androgenic alopecia. all treatments will be provided in a double-blinded fashion except for minoxidil 5% solution which will be provided open-label.


Eligibility criteria:
inclusion criteria: * mild to moderate male pattern baldness (androgenic alopecia) with ongoing hair loss for at least 1 year * willingness to have micro-dot-tattoo applied to scalp * willingness to maintain same hair style, length and hair color during study exclusion criteria: * drug or alcohol abuse within 12 months * hiv positive * received hair transplants or had scalp reductions * use of hair weaves, hair extensions or wigs within 3 months * oral or topical minoxidil treatment within 6 months * application of topical steroids or nonsteroidal anti-inflammatory drugs (nsaids) to scalp within 4 weeks
study of safety and efficacy of a probiotic and postbiotic in overweight individuals

Conditions: Obesity; Abdominal Obesity

Summary: investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.

this study aims to investigate the safety and efficacy of live and heat treated bacteria on body composition of overweight individuals. the trial will be run in a single research centre and will recruit adult men and women, with bmi of 25-33kg/m2 with abdominal obesity.

Eligibility criteria:
inclusion criteria: * body mass index 25-33kg/m2 * abdominal obesity (female waist circumference\>85cm; male waist circumference\>90cm) * written informed consent exclusion criteria: * taking the following medication within 1 month before starting the study: appetite stimulants/suppressants, lipid lowering drug, contraceptive * taking antibiotics within 2 months before starting the study * secondary obesity or secondary hypertension, diabetes type 1, gi disease, dyslipidaemia, type 2diabetes, hypertension * consumption of pre- and probiotic-enriched products or dietary supplement for at least 4 weeks prior to the first screening visit * nicotine, drug or alcohol abuse, * other condition that, in the opinion of the investigators, would make participation not in the best interest of the patient or could prevent, limit or confound the study's results
study to examine lesions of the skin using confocal laser microscopy

Conditions: Benign Skin Tumor; Basal Cell Carcinoma; Melanoma; Squamous Cell Cancer

Summary: using ex-vivo confocal laser scanning microscopy, a reliable statement can be made about the extent, histological structure and possible significance of a skin change without having to send tissue samples for demanding and lengthy histological examinations.

using ex-vivo confocal laser scanning microscopy, a reliable statement can be made about the extent, histological structure and possible significance of a skin change without having to send tissue samples for demanding and lengthy histological examinations.

Eligibility criteria:
inclusion criteria: * patients with benign and malignant skin tumors exclusion criteria: * patients unable to consent
characterization and differential diagnosis of postneurosurgical meningitis

Conditions: Neurosurgery

Summary: meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. the aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.

besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (csf) culture, and profiles of blood and csf inflammatory markers for the differential diagnosis of meningitis. csf culture will be extended upto 2 weeks. serum procalcitonin and c-reactive protein, csf adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.

Eligibility criteria:
inclusion criteria: * cerebrospinal fluid corrected wbc \>6/mm\^3 and/or fever (\> 38℃) and/or neck stiffness exclusion criteria: * patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination

Keywords: meningitis infection cerebrospinal fluid procalcitonin adenosine deaminase
multi-dose ibuprofen prophylaxis for iud-insertion

Conditions: Pelvic Pain; IUD

Summary: this study compares the effectiveness of decreasing pain at time of and day after intrauterine device (iud) insertion when patients take three doses of ibuprofen versus three doses of placebo.

ibuprofen is commonly used over the counter and prescribed for pain relief such as menstrual cramps. intrauterine (iud) insertion can cause pain during and after the insertion. currently, studies have found that single dose of ibuprofen take prior to iud insertion does decrease pain at time of iud insertion. this study will examine whether 3 doses of ibuprofen can decrease pain at time of and 1 day after iud insertion.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * female * able to provide informed consent * english speaking * able to provide telephone and address contact information * able and willing to receive hipaa compliant telephone texts and phone messages * stable (the same) address and phone number within the last 6 months. exclusion criteria: * contraindications to iud insertion (active pelvic infection, current pregnancy) * contraindications to nsaids (allergy, history of asthma, history of aspirin allergy, history of kidney disease, history of stomach ulcer, history of active gi bleeding, history of liver disease) * not undergoing any other concurrent office procedures

Keywords: nsaid intrauterine devices ibuprofen pelvic pain
comparative effects of theragun percussion therapy and compression therapy in the patients with migraine

Conditions: Migraine

Summary: the aim of this study is to compare the effects of theragun percussion therapy and compression therapy on pain, neck range of motion and quality of life in the patients with migraine

migraine is a type of unilateral headache characterized by recurrent attacks of moderate to severe pulsating pain which common symptoms include increased sensitivity to light, noise, nausea and vomiting. mechanical scalp compression is the most commonly used for temporary relief of migraine pain that originates from dilated blood vessels in the scalp. many percussive therapy devices are used for relax and soothe sore muscles as theragun helps in instant relief migraine pain. it will be a single blinded randomized clinical trial. non-probability convenience sampling technique will be used to recruit 56 participants of 18 to 50 years of age from riphah rehabilitation care centre and sir ganga ram hospital, lahore. the participants will be then randomly assigned into two equal groups through random number generation table. in group a, percussion therapy will be applied by theragun device for 25 minutes in each session along with routine physical therapy treatment for 20 minutes. in group b, the compression therapy will be applied by migraine relief gel cap which works as compression device for head for 25 minutes in each session along with routine physical therapy treatment for 20 minutes. the treatment will be given for 5 times per week for 6 weeks. outcome measures for pre and post evaluation will be visual analogue scale (vas) for pain assessment, migraine screening quality of life questionnaire (ms-q) for quality of life, neck disability index (ndi) for neck disability, bubble inclinometer for neck range of motion. the data will be analyzed using spss version 24.

Eligibility criteria:
inclusion criteria: 1. both genders 2. 18 to 65 years' old 3. migraine without aura 4. headache with nausea or vomiting and light/sound sensitivity 5. unilateral headache from past 3 months at least once a week 6. ichd-3 criteria of migraine exclusion criteria: 1. congenital condition of cervical spine 2. inability of neck to perform flexion-rotation test 3. meningitis, deep vein thrombosis 4. other-type of headache 5. headache attributed to trauma or injury to neck

Keywords: neck stiffness headache pnf strteching compression therapy
nutrition for health and performance in female collegiate soccer players

Conditions: Healthy

Summary: the purpose of this research study is to conduct a pilot trial using an app-based approach to improve the health and performance of female collegiate soccer athletes through nutrition education and personalized feedback. the app-based program is designed to promote better performance through education on sport-specific fueling and good nutrition practices.

objectives: combat female soccer athletes underfueling during their competitive season. study overview: this project proposes an open label, pilot research endeavor between the department of nutrition at case western reserve university (cwru), pennington biomedical research center (pbrc) and the ncaa division iii cwru women's soccer team. the proposed study design will implement a commercially available, dietitian-designed phone app, eat2win. eat2win provides targeted nutritional education, specifically for soccer athletes, to improve fueling for sport and health. additionally, eat2win's photo-based phone app technology will be used to provide individualized feedback to improve athlete fueling. anthropometric, aerobic fitness (vo2), resting metabolic rate, physical activity, body composition and health-related questionnaire data will be collected from a subset of athletes at three timepoints: pre-season, in-season, and post-season. biological measures from fingerstick blood and breath will be collected in a subset of participants at the three timepoints. general aims/hypothesis: our intervention will strive to improve athlete health and performance through nutrition education and personalized feedback using the eat2win app.

Eligibility criteria:
inclusion criteria: * currently active and ncaa-eligible (including academic standing) member of the case western reserve university (cwru) women's soccer team * owns a mobile device compatible with the eat2win dietary app platform * signed informed consent exclusion criteria: * pregnant women or women who are nursing * unwilling to provide anthropometric and/or biological (i.e. finger prick blood) samples during collection periods * history of diagnosed disordered eating

Keywords: relative energy deficiency in sport (red-s) performance health nutrition dietetics ehealth
investigation on the effect of smoking on the expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers in humans

Conditions: Inflammation; Thrombosis; Smoking

Summary: investigation on the effect of smoking on thrombus formation in humans. the expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50 year old healthy smokers and non-smokers. the investigators are interested in possible differences between the two groups.


Eligibility criteria:
inclusion criteria: * smoker * non-smokers exclusion criteria: * disease * pregnancy

Keywords: smokers non-smokers