find stroke recovery - a longitudinal study

Conditions: Stroke; Stroke Hemorrhagic; Stroke, Ischemic; Risk Factor, Cardiovascular; Cognitive Impairment

Summary: stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. some will recover fully after stroke and others will have permanent impairments. few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. also, the whole range of mechanisms leading to recovery are not precisely known (1). to monitor those mechanisms one can utilize biomarkers. in parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. biomarkers can later be used for outcome predictions after stroke.

background stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. some will recover fully after stroke and others will have permanent impairements. few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. also, the whole range of mechanisms leading to recovery are not precisely known (1). to monitor those mechanisms one can utilize biomarkers. in parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. biomarkers can later be used for outcome predictions after stroke. work plan aim determine temporal profiles describing the speed, order, and degree of recovery in neurological and cognitive functions in various domains with simultaneous profiling of changes in blood biomarker concentrations, in the acute, subacute phases and long-term of stroke. determine individual and interindividual variations in recovery in the different domains. informed consent written informed consent will be obtained from all willing participants or their next-of-kin.

Eligibility criteria:
investigators enrol patients presenting with first-ever ischemic stroke or intracerebral haemorrhage admitted to the stroke units at the sahlgrenska university hospital in gothenburg, sweden. the inclusion criteria are: • first-ever acute ischemic stroke; or intracerebral hemorrhage. the exclusion criteria are: * pre-stroke mrs score of ≥3; * severe neurodegenerative disease, cerebral neoplasm or terminal illness; and * patients considered unlikely to be able to participate in or to understand and/or comply with study procedures during follow-up visits at the hospital.

Keywords: recovery rehabilitation stroke severity plasticity modified rankin scale national institutes of health stroke scale fugl-meyer assessment blood sampling stroke subtype