Kornimate/medical-research-clean huggingface dataset:
smartphone addiction and temporomandibular joint dysfunction in individuals with nonspecific neck pain

Conditions: Smartphone Addiction, Temporomandibular Joint Dysfunction

Summary: it has been reported that excessive use of smartphones increases the stress on the cervical spine, and changes in cervical curvature and pain in the muscles around the neck are associated with the increase in stress. studies have reported that smartphone users with addictions have neck pain (68%), upper back pain (62%), right shoulder pain (52%), left shoulder pain (46%), and right hand pain (46%). as a result of our study, the frequency of smartphone addiction and temporomandibular joint dysfunction and related factors in individuals with nonspecific neck pain were examined and the results we obtained will contribute to the literature.


Eligibility criteria:
inclusion criteria: * presence of neck pain lasting at least 6 months * being between the ages of 18-45 * individuals with a score between 10-40 points according to the neck disability index * individuals who have never had a history of shoulder or neck surgery exclusion criteria: * individuals with signs of radicular pain (positive neck distraction test, spurling's neck compression test, and adson's test) * individuals who get less than 10 points or more than 40 points according to the neck disability index * those with a previous history of shoulder and neck surgery * individuals with accompanying shoulder pain * individuals with spinal cord tumors * individuals with meningeal tumors * individuals who do not want to participate in the study
mix vaccine for metastatic kidney cancer

Conditions: Metastasis From Malignant Tumor of Kidney (Disorder); Reaction - Mixed Vaccine

Summary: the aim of this study is the safety and efficacy of mix vaccine to small metastases of kidney cancer.

by enrolling patients with small metastases of kidney cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of mix vaccine. the safety will be evaluated by statistics of adverse reactions. the efficacy will be evaluated according to local relief degree, progress free survival (pfs) and overall survival (os).

Eligibility criteria:
inclusion criteria: * all standard therapies have failed according to nccn guidelines or the patient refuses standard therapies after cancer recurrence * body tumor 1-6, the maximum tumor length \< 2 cm * kps ≥ 70, lifespan \> 6 months * platelet count ≥ 80×109/l，white blood cell count ≥ 3×109/l, neutrophil count ≥ 2×109/l, hemoglobin ≥ 80 g/l exclusion criteria: * patients with cardiac pacemaker * patients with brain metastasis * patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction
effectiveness of truclear on patient quality of life

Conditions: Heavy Menstrual Bleeding

Summary: this study aims to evaluate the quality of life in patients treated for submucosal leiomyomas using the truclear hysteroscopic morcellator compared to women managed medically. study population includes women age 18 and older with symptomatic submucosal myomas. patients will be asked to complete the uterine myoma symptom and health-related quality of life questionnaire (ufs-qol) at enrollment and at 1, 3, and 6 months after treatment.

submucosal myomas are a common cause of pelvic complaints and abnormal uterine bleeding (aub) and there are many available modalities for treatment. hysteroscopic myomectomy is a minimally invasive approach for removal of submucosal leiomyomas. alternatively, medical management can be attempted. this study aims to evaluate the quality of life in patients treated for submucosal leiomyomas using the truclear hysteroscopic morcellator compared to women managed medically. study population includes women age 18 and older with symptomatic submucosal myomas. patients will be asked to complete the uterine myoma symptom and health-related quality of life questionnaire (ufs-qol) at enrollment and at 1, 3, and 6 months after treatment.

Eligibility criteria:
inclusion criteria: * patients with abnormal uterine bleeding and submucosal fibroid(s) undergoing hysteroscopic myomectomy or medical therapy with oral contraceptive pills * patients with type 0, 1 or 2 submucosal myomas exclusion criteria: * pregnant women * patients with suspicion of uterine malignancy * patients without submucosal fibroid seen during planned hysteroscopic myomectomy * patients with active vaginal infection * patients with contraindication to hysteroscopic myomectomy * patients with cognitive impairment who are unable to provide consent and adequately complete the questionnaire.

Keywords: submucosal fibroids heavy menstrual bleeding quality of life
aromatherapy for anxiety and self-esteem: clinical trial

Conditions: Anxiety; Self Esteem

Summary: the aim of this study was to determine whether the use of ylang ylang essential oil through dermal application or inhalation alters the perception of anxiety and self-esteem and physiological parameters such us blood pressure and temperature.

34 nurses from the university hospital participated in this study and were randomized into three groups: one that received the ylang ylang essential oil cutaneous route, the second received the essential oil inhalation and the third (placebo) received the essence of ylang ylang cutaneous route.

Eligibility criteria:
inclusion criteria: * be an employee of the nursing team and not be on probation * accept make use gel or freshener containing essential oil or essence ylang ylang * respond anxiety inventory(stai)and self-esteem scale and present moderate, high or very high anxiety on the stai, medium or low self-esteem on the scale self-esteem * accept not wear perfume during the survey period * accept the smell of ylang ylang. exclusion criteria: * self reported hypotension * medical license or vacation during the period

Keywords: anxiety self-esteem
antimicrobial susceptibility testing guided antibiotic selection strategies in salvage helicobacter pylori treatment

Conditions: Helicobacter Pylori Infection; Antimicrobial Susceptibility Testing

Summary: helicobacter pylori (h. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. strongly evidence supports that h. pylori eradication is an effective approach to reduce the incidence of those pathologies.


Eligibility criteria:
inclusion criteria: * consecutive patients who are 18-70 years old with persistent h. pylori infection after first or second line treatment attempts. exclusion criteria: * enable to undergo upper endoscopy; * patients with gastrectomy, acute gi bleeding and advanced gastric cancer; * known or suspected allergy to study medications; * taking bismuth and antibiotics in the previous four weeks, or taking proton pump inhibitor and h2-receptor blockers in the previous two weeks; * currently pregnant or lactating * inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.

Keywords: helicobacter pylori infection antimicrobial susceptibility testing (ast)
treatment of foot and leg ulcers using a laser

Conditions: Diabetic Foot Ulcer

Summary: the investigators plan to do a retrospective chart review on patients who underwent laser treatment for their foot ulcer at the ut southwestern wound clinic.

the investigators plan to do a retrospective chart review on patients who underwent laser treatment for their foot ulcer at the ut southwestern wound clinic starting on may 17, 2018 to november 13, 2018. the investigators chose this date because that is the first time laser treatments were performed in the clinic. the investigators will collect the following data points: * ulcer etiology * ulcer location * prior ulcer treatment type and duration, and wound measurements/characteristics * wound size 4-6 weeks prior to laser treatment; at treatment time; and then each follow up measurement healed or x weeks * egfr * albumin * last a1c-presence/absence of dm * amputation history * vascular status via abi's * identify comorbidities * identify associated encounters in the patients such as complications (i.e. infection), related readmissions the investigators will identify this information from patient charts (epic emr).

Eligibility criteria:
inclusion criteria: * patients who underwent laser treatment for their foot ulcer at the ut southwestern wound clinic starting on may 17, 2018 to november 13, 2018 exclusion criteria: * not meeting inclusion criteria
does gabapentin reduce quadriceps muscle weakness after anterior cruciate ligament reconstruction?

Conditions: Muscle Weakness; Anterior Cruciate Ligament Rupture

Summary: anterior cruciate ligament (acl) injury is a common sport injury in both professional and recreational athletes. furthermore, persistent quadriceps weakness and wasting are frequently observed after anterior cruciate ligament reconstruction (aclr). several studies have demonstrated that muscular rehabilitation to normal strength is difficult, protracted, and often not achieved due to the inability to fully activate the quadriceps voluntarily. pain and disuse are often blamed for the inhibition of muscle activation following joint injury. however, arthrogenic muscle inhibition (ami) is often overlooked and not addressed. thus, the magnitude of strength restoration of the quadriceps is frequently restricted despite solid rehabilitation protocols. as ami is a reflex inhibition of musculature involving the neurotransmitter γ-aminobutyrate (gaba), gabapentin may have a potential role in modulating ami, therefore limiting muscle weakness after aclr.


Eligibility criteria:
inclusion criteria: 1. age 18-50 2. unilateral isolated acl tear for primary aclr confirmed clinically and radiologically 3. no concomitant ligamentous, meniscal or chondral injuries. exclusion criteria: 1. concomitant multiple ligament injuries including posterior cruciate ligament, medial collateral ligament ligament, or lateral collateral ligament 2. concomitant meniscal injuries 3. concomitant chondral injuries 4. preoperative radiographic signs of arthritis 5. revision acl surgery 6. contralateral knee with 7. medical co-morbidities including diabetes mellitus, chronic renal failure 8. documented hypersensitivity to gabapentin 9. history of epilepsy 10. history of depression 11. non-compliance to rehabilitation protocol.
effects of aerobic interval training on fatigue level and functional performance in post angioplasty patients

Conditions: Coronary Artery Disease

Summary: the goal of this randomized controlled trial is to determine the effects of aerobic interval training on levels of tiredness and functional performance in post-angioplasty patients. the main question it aims to answer is: does aerobic interval training reduce fatigue and improve functional performance compared to medication alone in post-angioplasty patients? participants will: be randomly assigned to either the control group (medication) or the experimental group (medication + aerobic interval training) perform aerobic interval training for 30 minutes, three times a week, for six weeks (experimental group only) complete pre and post-intervention assessments using the fatigue severity scale, the 6-minute walk test, and the one minute sit to stand test researchers will compare the two groups to see if aerobic interval training leads to significant improvements in fatigue levels and functional performance.

the study is a randomized controlled trial that aims to evaluate the effects of aerobic interval training (ait) on fatigue level and functional performance in post-angioplasty patients. the study involves 47 participants who have undergone percutaneous coronary intervention (pci) for coronary artery disease (cad) and have completed phase 1 of cardiac rehabilitation. the participants are divided into two groups: group a receives medication only, and group b receives medication plus ait. the ait consists of four sessions per week for four weeks, with each session lasting 40 minutes and alternating between high and low-intensity intervals. the study hypothesizes that ait will have a positive effect on fatigue level and functional performance in post-angioplasty patients, compared to medication alone. the study uses descriptive statistics, paired t-tests, and independent t-tests to analyze the data and test the hypotheses.

Eligibility criteria:
inclusion criteria: * patient with post angioplasty (having 1 or 2 stents) * patient who completed phase 1 cardiac rehabilitation * post coronary angioplasty patients 2 weeks of hospital discharge. exclusion criteria: * patients with neurological disorders * patients with valvular and obstructive airway diseases. * patients with acute infections, malignancy * angioplasty complications such as arrhythmias, blood clots in-stent, and atrial fibrillations * patients with uncontrolled hypertension. * patients with uncontrolled diabetes. * presence of fracture.

Keywords: angioplasty coronary artery disease fatigue recovery of function rehabilitation
a study to evaluate the safety and efficacy of a single dose of rabi-767 in participants with acute pancreatitis

Conditions: Acute Pancreatitis

Summary: the goal of this clinical trial is to test the safety and effectiveness of a single dose of rabi-767 given by endoscopic ultrasound (eus) guided peripancreatic injection in participants with predicted severe acute pancreatitis. the main question the study aims to answer is: • is a single-dose of rabi-767 given by eus-guided peripancreatic injection safe in patients with predicted severe acute pancreatitis. the study also aims to answer: • is a single-dose of rabi-767 given by eus-guided peripancreatic injection effective in treating patients with predicted severe acute pancreatitis. study participants will be randomly assigned (like the flip of a coin) to receive a single dose of rabi-767 plus supportive care or supportive care only. the study sponsor will compare safety and efficacy data collected from participants who receive rabi-767 to participants who receive supportive care only to test if rabi-767 is safe and effective.


Eligibility criteria:
key inclusion criteria: * diagnosis of acute pancreatitis * predicted severe acute pancreatitis, based on protocol defined criteria * lack of clinically meaningful improvement from status at admission, at the discretion of investigator, at the time of randomization * suitable for eus-guided study drug administration procedure * contrast-enhanced computed tomography (cect) or magnetic resonance imaging (mri) of the abdomen/pancreas available for the evaluation of exclusion criteria key exclusion criteria: * confirmed severe acute pancreatitis as defined by the revised atlanta classification of acute pancreatitis (ie, persistent \[\> 48 hours\] organ failure, per modified marshall score), prior to randomization * anticipated discharge from hospital within 48 hours of randomization * more than 30% pancreatic necrosis on screening cect or mri * history of previous pancreatic necrosis, including necrosectomy * history of calcific chronic pancreatitis * evidence of cholangitis
ketamine in patients undergoing tevar procedures receiving nci

Conditions: Descending Aortic Dissection; Postoperative Pain; Thoracoabdominal Aortic Aneurysm

Summary: the objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (tevar) procedures receiving naloxone continuous infusion (nci).

patients undergoing descending aortic repair often experience post-operative pain, and have high post operative opioid requirements. that pain is partially due to the use of naloxone continuous infusion (nci). nci is part of a bundled approach used in the first 48 hours post-operatively to prevent spinal cord ischemia, a devastating complication associated with surgical repair of the descending aortic. data indicate that patients receiving nci experience elevated post-operative pain scores and increased opioid requirements during the 48-hr post-operative nci administration, compared to patients not receiving nci. ketamine is an fda-approved n-methyl d-aspartate (nmda) antagonist that has been shown to provide adjunctive analgesia and opioid-sparing effects in post-operative surgical patients. at low doses, ketamine provides analgesic benefit without the anesthetic effects seen at higher doses. these doses are commonly referred to sub-dissociative. this study will evaluate whether use of sub dissociative ketamine (sdk) in patients undergoing aortic procedures with the use of nci will lead to decreased post-operative opioid consumption, and produce improved pain scores in the first 48 hours.

Eligibility criteria:
inclusion criteria: * willing to give informed consent * scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair * requires naloxone continuous infusion for spinal prophylaxis exclusion criteria: * allergy to ketamine, acetaminophen, or fentanyl * diagnosis of schizophrenia * history of hydrocephalus or central nervous system mass * incarcerated individuals * pregnant or lactating individuals

Keywords: naloxone ketamine aortic repair spinal cord ischemia
health-related quality of life in general slovenian population

Conditions: Health-related Quality of Life

Summary: the purpose of the study is to obtain reference data on health-related quality of life for the functional and symptom scales and single items of the european organisation for research and treatment of cancer core quality-of-life questionnaire (eortc qlq c30) in a representative sample of slovenian general population.

a sample of at least 600 people from the slovenian population, randomly selected, age 18 years and more, representing geografic diversity, will take part in this postal survey. the eortc qlq c30 and a questionnaire about demografic data will be send by mail. this is the first study to obtain reference data from the eortc qlq c30 in a sample from the general slovenian population. the results will serve as guidelines for interpreting health-related quality-of-life of different groups of patients.

Eligibility criteria:
inclusion criteria: * age 18 y and more exclusion criteria: * serious comorbidity * previously treated for cancer

Keywords: quality of life general slovenian population eortc qlq c30
clopidogrel resistance and embolism in carotid artery stenting

Conditions: Carotid Stenosis

Summary: the purpose of this study is to evaluate the efficacy and safety of the ticlopidine + ginko biloba compared to clopidogrel in clopidogrel resistant patients undergoing carotid artery stent placement. the investigators hypothesized that ticlopidine + ginko biloba is superior than clopidogrel in terms of post-stent ischemic lesions in these patients without serious complications.


Eligibility criteria:
inclusion criteria: * patients scheduled for stent implantation due to carotid stenosis * patients resistant to clopidogrel defined by platelet inhibition rate \<20% measured by verify now before carotid stenting * patients with informed consent exclusion criteria: * antiplatelet therapy other than aspirin, clopidogrel, or ticlopidine * unable to perform mri scans * patients with hematologic abnormalities including neutrophil \ 120 u/l * unsuitable for participation

Keywords: carotid stenosis stenting clopidogrel resistance stroke, ischemic
follow-up study of icus and ccus patients

Conditions: Myelodysplastic Syndromes

Summary: the proposed minimal diagnostic criteria for myelodysplastic syndromes (mds) and potential pre-mds conditions has been released by an international consensus group. based on the criteria, patients with persistent cytopenia could be diagnosed with mds, ccus and icus. however, the process and outcome of pre-mds conditions (ccus, icus) is still to be characterized in chinese population. we design this prospective observational study to explore the disease process and outcome in icus and ccus patients.


Eligibility criteria:
inclusion criteria: * patients with cytopenia of any degree in one or more lineages: erythrocytes, neutrophils, or platelets. and the cytopenia has to be persistent (≥ 4 months) and lacking minimal diagnostic criteria of mds. exclusion criteria: * patients with cytopenia which could be explained by any other hematologic or non-hematologic disease.

Keywords: idiopathic cytopenia of undetermined significance (icus) clonal cytopenia of unknown significance (ccus)
prospective observational association between slco1b1 gene polymorphism and the anti-factor xa activity of edoxaban in patients with moderate to severe renal insufficiency

Conditions: Gene Polymorphism; Edoxaban; Renal Insufficiency

Summary: 1. to provide reference for clinical rational use of edoxaban; 2. optimize the individualized dosing regimen of edoxaban.

in this study, patients with moderate and severe renal insufficiency receiving edoxaban were selected as research objects. the potential safety of edoxaban in patients with different genotypes was evaluated by detecting the anti-xa factor activity and slco1b1 genotyping, so as to optimize the individualized administration regimen of edoxaban.

Eligibility criteria:
inclusion criteria: * creatinine clearance of 15-50ml/min was calculated according to the cockcroft-gault formula * patients who received edoxaban 30mg once daily for more than 5 days for non-valvular atrial fibrillation (chads2vas2 score ≥2) and deep vein thrombosis prevention or treatment * patients voluntarily participate and sign informed consent exclusion criteria: * age \< 18 years old * moderate/severe mitral stenosis combined with valvular heart disease, mechanical valve replacement, or rheumatic heart disease * the patient had used a combination of cyclosporine, erythromycin or ketoconazole or other p-glycoprotein inhibitors within 30 days prior to use or inclusion; patients were using or had used amiodarone or dronedarone within 30 days prior to inclusion

Keywords: anti-factor xa activity edoxaban moderate to severe renal insufficiency solute carrier organic anion transporter family member 1b1
acute tear production following single use of the oculeve intranasal neurostimulator

Conditions: Dry Eye Syndrome; Keratoconjunctivitis Sicca

Summary: the primary objective of this study is to evaluate acute tear production as measured by tear meniscus height (tmh) captured by optical coherence tomography (oct) after single use of the oculeve intranasal neurostimulator (oin) in participants with dry eye.

this is a prospective, single-arm, multicenter, open-label clinical trial in which participants will use the oin once following study enrollment.

Eligibility criteria:
inclusion criteria: * subjects with dry eye disease * literate, able to speak english or spanish, and able to complete questionnaires independently * willing to sign the informed consent and deemed capable of complying with the requirements of the study protocol exclusion criteria: * chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the opinion of the investigator, may lead to clinically significant increased bleeding * nasal or sinus surgery (including history of application of nasal cautery) or significant trauma * cardiac demand pacemaker, implanted defibrillator or other implanted electronic device * corneal transplant in either or both eyes * participation in any clinical trial with a new active substance or a new device within 30 days of the screening visit * women who are pregnant, planning a pregnancy, or nursing at the screening visit