Kornimate/medical-research-clean huggingface dataset:
clinical, radiographical, histological evaluation and blood flow analysis of alveolar ridge preservation

Conditions: Alveolar Bone Loss

Summary: with alveolar ridge preservation (arp) ridge resorption following extraction may be reduced. several materials and techniques have been advocated for arp. the aim of our randomised clinical trial is to evaluate the efficacy of extraction side development technique (xsd) and autogenous tooth bone graft (atb) for arp.

a three armed clinical study will be established. according to the sample size calculation, every arm will contain 21 participants. the first group is the socket seal group. in the second group we aim to combine the socket seal and xsd technique. in the third group the xsd technique will be combined with the atb material. the primary outcome is the alveolar ridge width change in millimeter, measured immediately after the tooth extraction and after 6 months at the reentry procedure. the change in alveolar ridge width and vertical dimensional alterations will be also measured as secondary outcomes on the cbct at baseline and after 6 months. further secondary outcomes are the monitoring of gingival microvascularization, monitoring of flap revascularization by laser speckle contrast imaging and assessment of soft tissue volumetric changes by intraoral scanning and histomorphometric evaluation of the volumetric percentage of newly formed bone, connective tissue and graft material after a 6-month healing period in a core biopsy taken at the time of implant placement. hypothesis: the xsd and xsd+atb groups are expected to have less pronounced horizontal width losses. xsd group is expected to produce the highest graft turnover.

Eligibility criteria:
inclusion criteria: * women and men patients over 18 years co-operative patients with good individual oral hygiene (fmbs: 25%\>) patients with periodontal disease in treatment or under treatment with minimal active inflammation (fmps: 25%\>) local criteria: teeth with a hopeless prognosis with advanced periodontal or endo-periodontal defects, which are restored with implant prosthesis eds 3-4 extraction defects after tooth extraction exclusion criteria: * infectious diseases (hbv, hcv, hiv, cov-2019...) current chemotherapy or radiotherapy previous radiation therapy to the head and neck region (in the last 2 years) untreated insulin dependent diabetes mellitus clinically significant osteoporosis or other systemic disease affecting bone metabolism clinically significant circulatory disorder e.g.: decompensated cardiac failure haemodynamically significant valvular heart failure or myocardial infarction within the last 3 months clinically significant coagulopathy current or previous systemic corticosteroid therapy (in the last 2 months) current or previous systemic bisphosphonate therapy (beyond 30 days) pregnant or breastfeeding women smoking (max 5 cigarettes per day) drug addiction, alcoholism

Keywords: alveolar ridge preservation autogenous tooth bone graft extraction side development technique
interest of a systematic biopsy for hard-to-heal leg ulcers

Conditions: Chronic Leg Ulcers

Summary: primary aim of the study : to evaluate the prevalence of ulcerated cutaneous carcinoma or malignant degeneration, in leg ulcers, presumed of vascular origin and without evidence of healing despite 3 months of adequate treatmentsecondary aims of the study : to evaluate the interest of immunostainings for desmogleins 1-2 and p16 on biopsies to differentiate between pseudo epitheliomatous hyperplasia and squamous cell carcinoma ; and the prognosis of diagnosed carcinomas at 12 monthsstudy hypothesis : systematic biopsies of hard-to-heal leg ulcer may help to detect ulcerated carcinomas misdiagnosed as vascular ulcer or malignant degeneration of leg ulcer.

prospective multicentric inclusion of 150 patients with leg ulcers without any evidence of healing (no change or increase of ulcer area) despite 3 months of adequate treatment the study population consisted of consecutive patients with one or more leg ulcers, diagnosed as related to venous insufficiency, associated or not with concomitant arterial insufficiency. all patients undergo a standard treatment including compression therapy adapted to the ankle brachial index and a local treatment depending on the wound stage.at inclusion, systematic punch biopsies (5-6 mm) are taken as part of routine clinical care under local anaesthetic by an experienced clinician: 1 to 2 biopsies in the edges and 1 to 2 biopsies in the wound bedspecimens are transported in formalin solution to the usual pathology laboratory of the investigator. at the end of the study, specimens will be sent for immunostainings in a single pathology laboratory (rouen, france)treatments and/or other investigations are decided by the investigatorat 12 months of usual follow-up, final diagnosis and prognosis are noted in the study file by the investigator.

Eligibility criteria:
inclusion criteria: * leg ulcer of more than 3 months of duration * leg ulcer presumed of vascular origin * adequate etiologic treatment since 3 months * absence of evidence of healing : absence of reduction of wound area or increase in wound area and/or in depth exclusion criteria: * hypertensive ulcer * vasculitis * treatment by cytotoxic agents or steroids in the previous 3 months

Keywords: malignant transformation of leg ulcer marjolin's ulcer biopsy leg ulcer chronic wound squamous cell carcinoma basal cell carcinoma
"remind to move" treatment versus constraint-induced movement therapy for children with hemiplegic cerebral palsy

Conditions: Hemiplegic Cerebral Palsy; Upper Extremity Hemiplegia

Summary: the aim of this study was to determine the effects of an innovative child-friendly remind-to-move treatment (rtm) treatment by comparing it with constraint-induced movement therapy (cimt) on upper extremity outcomes in children with hemiplegic cerebral palsy. in an evaluator-blinded randomized controlled trial, 73 children, among of whom 20 in manual ability classification system level i, 38 level ii, and 15 level iii, were recruited from 3 special schools and randomized to receive 75-hour rtm (n=25) and cimt (n=24) programme over 15-weekdays, and conventional treatment (n=24). the primary outcomes were jebsen-taylor hand function test (jthft) and bruininks-oseretsky test of motor proficiency (botmp-ii) subtest 3 for assessing the motor efficiency at baseline, posttest, and 1- and 3-month follow-up.


Eligibility criteria:
inclusion criteria: * diagnosis of hemiplegic cerebral palsy * aged 5 to 16 years * ability to follow instructions * ability to grasp and release light objects, and at least 20° wrist and 10°fingers in metacarpophalangeal joints extension from full flexion for the affected hand * manual activity classification system (macs) 19 grades i, ii or iii of the affected hand exclusion criteria: * severe cognitive, visual, or auditory disorder * seizure and health problems not associated with cerebral palsy * predominant spasticity or contracture grades more than 3 of modified ashworth scale 20 on wrist and finger flexors, forearm pronators and ⁄ or thumb adductors * receiving new pharmaceutical (i.e. botulinum toxin injections) and/or surgical interventions within 6-month before study
fenoldopam and splanchnic perfusion during cardiopulmonary bypass

Conditions: Cardiac Complications; Cardiopulmonary Bypass

Summary: cardiopulmonary bypass (cpb) for cardiac operations may be accompanied by different patterns of visceral underperfusion. this could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for mesenteric infarction (0.2% of the cases). renal function as well may be impaired due to a low oxygen delivery, and acute renal failure occurs in 1-2% of cases. fenoldopam mesilate is a selective splanchnic vasodilator when used at a dose \< 0.1 mcg/kg/min. the experimental hypothesis of this randomized, controlled trial (rct) is that the use of fenoldopam may determine a better visceral perfusion during cpb.

randomized placebo-controlled double blinded study. patients undergoing complex cardiac operations will be randomly allocated to the study or the control group. all the patients will receive the standard of care of our institution. adequacy of cpb perfusion will be assessed using oxygen delivery calculation, lactate production, svo2.

Eligibility criteria:
inclusion criteria: * complex, combined cardiac operation * predicted cpb duration \> 90 minutes exclusion criteria: * age \< 18 years * no written informed consent

Keywords: cardiopulmonary bypass lactic acidosis oxygen delivery acute renal failure outcome cardiac surgery
grape seed extract vs low level laser therapy for dentin hypersensitivity

Conditions: Dentin Hypersensitivity

Summary: dentin hypersensitivity (dh) is a common clinical problem frequently seen in dental patients. according to splieth et al., the prevalence of dentin hypersensitivity is 3-98% in adult population.dh is described as a short, sharp pain or discomfort that responses to certain stimuli, typically thermal, tactile, osmotic or chemical, due to exposed dentinal surface which can be explained by the hydrodynamic theory. the laser is a narrow, focused beam of light emitted to vaporise, fuse, melt, or seal dentinal tubules using laser heat to induce hydroxyapatite crystals for recrystallisation of the mineral component of dentine. the obliteration of dentinal tubules is caused by heat generated by laser beam which inhibits the transmission of the stimulus in the dentinal tubules. grape seed extract contains proanthocyanidins (pa) which is able to bind to proline-rich proteins, like collagen, and contributes in enzyme proline hydroxylase activity that is essential for the biosynthesis of collagen in the dentin. the cross-linking action of collagen fibrils in dentin also able to prevent mineral loss.


Eligibility criteria:
inclusion criteria: * patients with at least three sensitive tooth by gingival recession or tooth wear \>2 scores on the vas scale. * tooth wear index score \<3 (smith and knight tooth wear index) * systemically healthy patient. * 20-50 years of age. exclusion criteria: * teeth with caries, cracked teeth, mobile teeth and pulpitis. * deep periodontal pockets (probing depth \>6 mm), periodontal surgery within the previous 3 months. * recent desensitizing therapy * systemic diseases and gastric diseases (gerd) * allergy to active ingredients.
plant-based dietary intervention in type 2 diabetes-2

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to assess whether, in individuals with type 2 diabetes, a low-fat, vegan diet improves blood glucose control more effectively than a control diet based on current american diabetes association (ada) guidelines. the principal measure is hemoglobin a1c. cardiovascular risk factors and dietary acceptability are also assessed. the study duration is 20 weeks with a one-year follow-up.

preliminary evidence suggests that low-fat, vegetarian regimens similar to those used to reverse coronary artery blockages may have a significant beneficial effect on type 2 diabetes, as demonstrated by reductions in fasting serum glucose concentrations and medication use. the investigators therefore randomly assigned 99 individuals with type 2 diabetes to either a low-fat, vegan diet or a diet based on current american diabetes association guidelines for 22 weeks with a one-year follow-up period. the principal dependent measure is hemoglobin a1c. cardiovascular risk factors are also being tracked, as is dietary acceptance.

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes mellitus exclusion criteria: - hemoglobin a1c values \ 10.5% use of insulin for \> 5 years tobacco use within the preceding 6 months consumption of more than 2 alcoholic beverages per day current drug abuse pregnancy unstable medical status current use of a low-fat, vegetarian diet.

Keywords: diabetes mellitus, type 2 diet, vegetarian diet, fat-restricted glycemic index
study of glycogen storage disease expression in carriers

Conditions: Glycogen Storage Disease

Summary: the purpose of the study is to determine whether carrier status for any type of glycogen storage disease (gsd) predisposes the carrier to gsd markers, like high cholesterol, by testing blood, urine, and saliva samples.

subjects will be asked to contribute about a teaspoon of blood, 1 oz of urine, and 2 tablespoons of saliva samples in the morning before they have had anything to eat. the blood and urine samples will be tested for the markers of gsd, while the saliva sample will be used for genetic testing. subjects' height and weight will also be measured. subjects will also be asked to fill out a questionnaire about symptoms common to full gsd expression that they may have experienced, as well as if they are currently on any medication to control their cholesterol.

Eligibility criteria:
inclusion criteria: * parents and other family members of patients undergoing treatment for gsd at the university of florida exclusion criteria: * pregnant females
the investigation of children with developmental delay and children's rehabilitation common case

Conditions: Developmental Disabilities

Summary: children with developmental disabilities and children's rehabilitation common case investigation: long-term follow-up study.

three fundamental goals of early rehabilitation for children with dd are: optimizing body function within each child's prognostic potential, preventing the development of secondary conditions that impact life-long health, and promoting children's participation in their lives. knowledge of these developmental patterns of fpla may be helpful in understanding, anticipating, and managing the problems of these patients. the investigators hypothesize that the course of developmental patterns in function and participation in life activities (fpla) of patients with dd evolves with their age. the levels of functional recovery included developmental function, activity, participation, and quality of life (qol). the aim of this study is to investigate the longitudinal outcomes in patients with dd evaluated by developmental function, activity, participation, and qol. additionally, the predictors in the initial stage in determining the final developmental patterns in fpla of these children will be identified.

Eligibility criteria:
inclusion criteria: 1. children with aged 0-20 years 2. control group: children with orthopedic disease, experimental group: children with developmental disabilities exclusion criteria: 1. low cooperative with follow-up 2. low cooperative with clinical assessment 3. low cooperative with questionnaire writing and data collection

Keywords: developmental delayed orthopedic disease longitudinal study
effects of manual therapy and respiratory muscle training on the maximal inspiratory pressure in patients with asthma

Conditions: Manual Therapies; Respiratory Muscle Training; Exercise Therapy; Inspiratory Capacity; Asthma

Summary: the aim of this study is to assess if an intervention of manual therapy and motor control exercises combined with an inspiratory muscle training program is more effective than an inspiratory muscle training program alone in increasing the maximum inspiratory pressure in patients with asthma. in addition, the study pretends to evaluate the changes caused by the intervention regarding possible postural changes and thoracic diameter.


Eligibility criteria:
inclusion criteria: * asthmatics subjects aged between 18 and 65 years exclusion criteria: * were excluded participants who presented neurologic, psychiatric or cognitive pathologies which difficult the cooperation, inflammatory disease of the cervical spine and/or severe orthopedic problems that difficult the daily activities, history of thoracic surgery, vertebral fracture, abnormal thorax radiography, spinal and thoracic structured musculoskeletal disorders and to present any contraindication of treatment techniques (e.g. ostheophorosis). in case of exacerbation of asthma, missing more than one treatment session and/or to appear any contraindication to continue the treatment routine during the six weeks of the study the patient also were excluded.

Keywords: asthma inspiratory muscle training manual therapies
sam: discharge based on the use of a muac-based criterion to

Conditions: Severe Acute Malnutrition

Summary: retrospective analysis of routine program data of children aged 6 to 59 months admitted to the msf therapeutic feeding program with muac ≤ 118 mm in yako and titao districts of burkina faso from 2007-2011.

comparison of patient characteristics and treatment outcomes was conducted between two groups: 1) children discharged as recovered from september 2007 to march 2009 with at least 15% of their weight at admission (period a); and 2) children discharged as recovered from april 2009 to december 2011 with muac ≥ 124 mm (period b). a total of 50,841 children were admitted with muac ≤ 118 mm to the msf therapeutic feeding program and were included in this analysis: 24,792 children in period a (2007-2009) and 26,049 children in period b (2009-2011). overall, 89% of admissions were directly into outpatient care and the majority (53%) entered with a muac 116-118mm; 48% of children were male and 80% of children \< 2 years of age (table 1). compared to children admitted in period a, children admitted in period b were statistically more likely to be female, younger, and of better anthropometric status (e.g. higher mean muac, whz and haz). there was a greater proportion of children admitted directly to inpatient care in period b than in period a (10.6% vs 8.0%).

Eligibility criteria:
inclusion criteria: * 6 to 59 months old * presence of bipedal pitting edema or muac ≤ 118 mm exclusion criteria: * \ 59 months old * absence of bipedal pitting edema or muac ≥ 118 mm
obstructive sleep apnea and down syndrome: clinical examination issue

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a common condition of down syndrome patients. in pediatric practice, there is no way to determine the children with an increased risk. the aim of the study is to determine the reliability of four questionnaires used in pediatric patients in screening of osa in down syndrome children. prospective study where patients are evaluated on airway diseases and aeroallergens sensitization with 2 parental surveys (psq-srbd and cshq), otolaryngologic problems by completing by the ent surgeon 2 others surveys (cas-15 and scr), and sleep disease with an overnight polysomnography (psg), in university hospital in nice.

introduction: children with down syndrome (ds) commonly have obstructive sleep apnea (osa) though undervalued by parents and physicians. several sleep questionnaires are used in paediatric patients to detect high risk children who have osa, but not really appropriate for ds patients. the aim of the study is to determine the reliability of four questionnaires used in paediatric patients (psq-srbd: pediatric sleep questionnaire-sleep-related breathing disorder, cshq: children's sleep habits questionnaire, cas-15: clinical assessment score-15 and scr: sleep clinical record) in screening of osa in ds population. study design: prospective study concerning children with down syndrome (age 1-18y). parents will complete two sleep symptom questionnaires (psq-srbd and cshq) and children will be evaluated by a paediatric pulmonologist and allergist with skin allergy test. an ear, nose and throat specialist will complete two questionnaires (cas-15 and scr) carrying a nasopharyngoscopy. then, children will perform an overnight polysomnography in the department of paediatric functional investigations of university hospital in nice.

Eligibility criteria:
inclusion criteria: * age under 18 years * down syndrome with cytogenetic diagnosis * state health cover * consent of legal representative and/or patient exclusion criteria: * polysomnography with correct results during the 12 months before
impact of human papillomavirus carriage on ivf/icsi results (hpv amp)

Conditions: Human Papilloma Virus; Infertility, Female

Summary: the prevalence of the papilloma virus in the general population is 12%. this virus is known to impair male fertility but its impact on female infertility remains uncertain. this is a public health problem since there is a vaccination protocol. demonstrating the impact of the human papillomavirus on fertility would be an argument in favor of vaccination.

this is a single-center prospective study in the assisted reproduction center of brest university hospital. all new patients coming to consult will be offered participation in the study. the hpv test will be updated if it is older than 12 months. we will analyze stimulation results and pregnancy outcomes according to hpv status. inclusions will take place over 3 years

Eligibility criteria:
inclusion criteria: * all etiology of infertility amh \> ou = à 1.1 ng/ml first ou second protocol of ivf between 25 years and 37 years and 11 months exclusion criteria: age \ ou = 38 y amh \< 1.1 ng/ml patient under juridic protection rejection of participation
ridge augmentation in posterior mandible using tunneling technique with amix of autogenous bone and xenograft with and without collagen membrane

Conditions: Alveolar Ridge Augmentation

Summary: aim evaluation of the amount of bone gain following ridge augmentation using tunneling technique in atrophic posterior mandibular ridges using anorganic bovine bone derived mineral mixed with particulated autogenous bone chips with collagen membrane

bone grafting before implant placement has become a routine procedure over the last 20 years. a 5-year survival rate of up to98.3% for implants placed in grafted bone has been reported. autologous bone grafts are considered the gold standard.however, the success rate of the grafting procedure may beinfluenced by various risk factors. a particular challenge isposed by an extensive graft of the alveolar ridge, with relativelyhigh complication rates of up to 20% being reported, mostcommonly dehiscence. more serious complications such asdehiscence or mobilization of the graft were observed in one third of smokers compared to a complication rate of only 7.7%for non-smokers. complications such as flap necroses, dehiscenceand resorption are frequently soft-tissue complications. a tension-free wound closure is a key factor in the successof bone grafts. periosteal incisions are a common techniquefor flap extension. however, too many relief incisions in the periosteum may also result in an excessively thin or stretched wound flap. this type of soft-tissue management may result in perforation or flap necrosis above the bone graft. in 1987 härle reported on a tunneling access in connectionwith a technique for preprosthetic jaw ridge grafting in the mandibular side-tooth region with bone replacement materials. in the clinical experience of the authors the use of a tunneling technique for preparation without a crestal incision can present an alternative with autologous bone grafts to conventional surgical procedures with a trapezoid flap design.

Eligibility criteria:
inclusion criteria: * medically free,age 22:50 years, atrophic posterior mandibleclinical diagnosis of alzheimer's disease must be able to swallow tablets exclusion criteria: smoking insulin dependent diabetes clinical diagnosis of alzheimer's disease must be able to swallow tablets

Keywords: tunneling technique collagen membrane tunnel augmentation horizontal ridge augmentation bone graft ridge augmentation posterior mandible