Kornimate/medical-research-clean huggingface dataset:
thyroid disease and personality study

Conditions: Graves' Disease

Summary: observe the relationship between thyroid function and personality traits

thyrotoxicosis was the biochemical and physiological manifestations of excess thyroid hormone. the clinical manifestation was palpitation, heat intolerance, hand tremor, and weight loss. the clinical manifestation also included nervous system, including anxiety, tension, irritability, hyperactivity, fatigue, and insomnia. where tensions features include restless, short attention span, and the impulse to want to move around. some patients will progress to a non-specific psychiatric disorders. according to the study, about 10% of patients will occur very frank psychosis, 3, 31% to 69% of patients with depressive symptoms, 61% to 62% of patients with symptoms of anxiety. some studies using reliable evaluation tool to evaluate behavioral changes in patients with thyrotoxicosis, such as clyde emotional scale, multi-faceted personality assessment table (multiphasic personality inventory (mmpi)), or observation of a response time to visual or audio stimulation. after treatment of thyrotoxicosis, most of these indicators have improved, but some indicators were still abnormal after treatment of thyrotoxicosis, such as mmpi and voice response time. the physiological causes of the changes of these nervous system is not clear. the symptoms was improved after the use of sympathetic inhibitors, so presumably this may correlated with autonomic nervous system disorders. thyroid hormone receptors are widely distributed in the brain may also be one of the cause. but there still some other reasons for the changes of neurological symptoms because neurological symptoms may not be back to normal even after thyroid function returned to normal. autoimmune dysfunction affect brain function may be the most possible reason. graves' disease is the most common cause of thyrotoxicosis and it is related to autoimmune thyroid antibodies. clinically, some patients of graves' disease may combined with other autoimmune disease, such as sicca syndrome. the patient may still have nervous personality traits despite normalized thyroid function. some patients even need long-term use of anti-anxiety medication. in this study, investigators hope to analyze the personality traits of patients with hyperthyroidism,especially patients of graves' disease, in taiwan and to observe the changes during treatment. investigators also hope to observe the statistical change of other non-thyroid-specific autoimmune index in this thyrotoxicosis patient. after obtaining these results, investigators will evaluate whether to continue to study the hypothesis of affection of brain of thyrotoxic patients by the abnormal autoimmune system.

Eligibility criteria:
inclusion criteria: * aged between 20 and 85 years * euthyroid graves' disease exclusion criteria: * patients who were not capable to complete the questionnaire due to severe cognitive dysfunction or under education were excluded from this study

Keywords: graves' disease hyperthyroidism personality traits
natural history, diagnosis, and outcomes for leukodystrophies

Conditions: Leukodystrophy

Summary: the goals of this protocol is to diagnose, care for, and understand the clinical histories and outcomes of people with leukodystrophies.

inherited leukodystrophies affect close to 1 in 7500 children with mortality greater than 30%. affected patients face additional serious medical complications including epilepsy, developmental regression, and intellectual disabilities. diagnosis is difficult and requires the assistance of a specialist. finally, identifying treatments and improving outcomes is complex. the western leukodystrophy project, which is part of the university of utah and of primary children's hospital, and which is a certified leukodystrophy care network center, provides a specialized resource for patients with leukodystrophies. this clinical study assists with diagnosis of leukodystrophies; suggesting treatment options and implementing care guidelines, and improving outcomes for all patients by understanding the clinical histories and outcomes of affected patients..

Eligibility criteria:
inclusion criteria: * evidence by clinical exam, radiological findings, and/or testing, of an inherited leukodystrophy. * be able to travel to the leukodystrophy clinic (at primary children's hospital, salt lake city, utah); * be able to tolerate a general physical exam, and a neurological exam. exclusion criteria: * unable to be evaluated at the university of utah hospital or primary children's hospital; * refusal to sign study consent form; * evidence or finding of another non-genetic cause of their condition; * persons with known white matter disease or lesions related to: birth injury or prenatal injury, multiple sclerosis, trauma, infection, immunization, or post-infectious effects (e.g. adem- acute disseminated encephalomyelitis), metabolic disturbance (e.g. central pontine myelinolysis), neoplasms, primary rheumatologic diseases (e.g. systemic lupus erythematosis), stroke, hypoxic-ischemic injury, drug or toxin effect, seizures, or endocrine disturbance.
treatment of depression post-sci

Conditions: Depression; Spinal Cord Injuries

Summary: depression is more common after a spinal cord injury (sci) than in the general population. unfortunately, it is unknown how depression is typically treated in individuals with sci or if commonly used treatment methods are effective. this study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rtms). rtms is a type of non-invasive brain stimulation. fourteen individuals with a cervical or thoracic level sci and depression will complete an approved treatment plan using rtms. participants will be treated using rtms five days a week for four weeks. after four weeks of treatment, the study team will review the safety of rtms and assess changes in depressive symptoms. if the results are positive, larger studies can be designed to develop better treatment options for individuals with sci and depression.


Eligibility criteria:
inclusion criteria: 1. age 18 - 70; 2. at least 6 months post incomplete cervical or incomplete or complete thoracic level sci; 3. have at least partial active movement of the right thumb (abductor pollicis brevis) to allow for fda approved rtms dosing; 4. major depressive disorder, as identified through screening tools; 5. no antidepressant medications or no change in doses of psychotropic medication(s) for at least 4 weeks prior to the study (6 weeks if newly initiated medication). exclusion criteria: 1. concomitant neurologic diseases/disorders or dementia; 2. cognitive impairment, as identified through a screening tool (montreal cognitive assessment); 3. history of major head trauma as identified through a screening tool (ohio state university traumatic brain injury identification method); 4. history of psychosis or other axis i disorder that is primary; 5. positive screen for bipolar disorder, as identified through a screening tool (the mood disorder questionnaire); 6. life expectancy \<1 year; 7. attempt of suicide in the last 2 years; 8. electronic or metallic implants (i.e. metal in the head, cochlear implant, or pacemaker); 9. history of seizures or currently prescribed anti-seizure medications; 10. taking medication that increases the risk of seizures; 11. pregnancy as identified through a positive pregnancy test; 12. inability or unwillingness of subject or legal guardian/representative to give informed consent.
early-start exercise training in subacute heart failure

Conditions: Chronic Heart Failure; Heart Decompensation

Summary: the purpose of this study is to evaluate the feasibility and the short-term effects of an early-start aerobic exercise training program on functional capacity, symptoms and neurohormonal activation in chronic heart failure patients with recent acute hemodynamic decompensation.

prescription of aerobic exercise training in stable chronic heart failure patients finds an evidence-based justification in the acknowledged long-term positive effects of aerobic exercise training on both functional capacity and prognosis in this population. in recent time, evidence has accumulated in normal subjects about short-term favorable effects of aerobic exercise training on sympatho-vagal balance and flow-mediated vasodilation, two physiological mechanisms known to be profoundly altered in the setting of acute hemodynamic decompensation of chronic heart failure. the possible extension of aerobic exercise training indication to chronic heart failure patients admitted for recent acute hemodynamic decompensation not stabilized as yet, may thus provide a valuable, low-cost tool to effectively manage such a high-risk and resource-absorbing population.

Eligibility criteria:
inclusion criteria: * history of chronic heart failure for at least 6 months, with ongoing acute decompensation defined as onset or worsening of heart failure signs and/or symptoms during the previous 15 days with need of intravenous diuretic and/or vasodilator therapy; * age \>18 years * left ventricular ejection fraction \<40% * probnp \>1000 pg/ml at admission exclusion criteria: * ongoing cardiogenic shock * need of intravenous inotropic therapy * acute coronary syndrome during the preceding 3 months * clinical and/or instrumental evidence of myocardial ischemia and/or life-threatening arrhythmias * previous cardiac valve surgery * creatinine \>2.5 mg/dl at admission * severe comorbidities limiting functional capacity

Keywords: chronic heart failure heart decompensation aerobic exercise training functional capacity dyspnea beta-adrenergic receptor signaling
multicentre registry of patients with spontaneous acute intracerebral hemorrhage in catalonia (hic-cat).

Conditions: Intracerebral Hemorrhage

Summary: a population-based registry in catalonia of patients with acute spontaneous intracerebral hemorrhage, to investigate whether type of center and time from onset to admission is associated with functional outcome and mortality.

introduction. recent studies show that there are potentially beneficial therapeutic measures for the patient with acute intracerebral hemorrhage (ich), which should be applied urgently and that some would only be available in tertiary stroke centers (tsc). however, the transportation criteria for ich patients are not well defined. objectives: design and implementation of a registry (hic-cat) of patients with hic in the healthcare network of public hospitals in catalonia, which does not modify the current logistics but collects data related to patients and tsc, interhospital transfers and non-tsc centers. the registry will allow us to evaluate the hypothesis that: 1) patient care in tsc decreases the probability of death or dependence in patients with spontaneous ich compared to non-tsc; and 2) the shorter the time until admission to a tsc, the better the survival and functional outcome. this will be due to the application of diagnostic, therapeutic and structural measures at the tsc. in addition, organ donation will be more frequent in a tsc. methods: observational, prospective, multicentre, population study of 2500 consecutive patients with spontaneous ich of less than 24 hours from the onset of symptoms and rankin scale score 0-3. we will collect times, clinical and radiological variables, vital and functional outcome at 3 months follow-up. number of organ donations. primary variable: functional outcome at 3 months (rankin 0-3). statistics: multivariate analysis with logistic regression, propensity matching scores.

Eligibility criteria:
inclusion criteria: * patient with a diagnosis of spontaneous intracerebral hemorrhage who is diagnosed in any of the participant hospitals exclusion criteria: * traumatic intracerebral hemorrhage * \>24 hours from onset to admission * prior rankin scale score \>3

Keywords: intracerebral hemorrhage outcome transportation transfer prognosis
physicians in training and critical care nurses performance in medical code events: effect of simulation-based training

Conditions: Ventricular Fibrillation

Summary: methods: subjects: all internal medicine (im), emergency medicine (em), anesthesia (a), surgery (s) residents and all hospital icu nurses (approximately 400 subjects) will be undergoing evaluation and training in cpr techniques according to their department training policy. study assessment tool: an objective assessment tool has been developed and tested in medical code scenarios during training sessions recently done in the simulation lab. the tool has five domains: airway, breathing, circulation, communications/leadership, and defibrillation. each domain consists of 3-8 tasks and skills (attachment a). design: * phase i: in groups of five to six subjects, residents and nurses will undergo baseline assessment in cpr techniques in the simulation lab. subject will be presented with a clinical scenario that includes cardiopulmonary arrest. subjects will be scored by observers based on the previously described assessment tool and will be video recorded. * phase ii: all study subjects who completed phase i assessment will undergo standardized debriefing and demonstration of proper cpr techniques after reviewing their individual baseline videotape followed by repeated demonstration in cpr techniques during a clinical scenario with cardiopulmonary arrest in the simulation lab. knowledge retention will be assessed periodically. * phase iii: rates of survival to hospital discharge and survival at 24 hours in hospitalized patients after cardiopulmonary arrest collected by the cpr committee and qa department longitudinally for one year after completion of project training (phase ii) will be reviewed and compared to the same period one year earlier (cpr outcome data are being collected since 2005 at st. luke's-roosevelt hospitals).


Eligibility criteria:
inclusion criteria: * physicians in training and nurses exclusion criteria: * physicians in training and nurses refusing to have their data included in final analysis
the study of the fenestrated anaconda device in the treatment of abdominal aortic aneurysms

Conditions: Vascular Diseases; Aneurysm

Summary: the french ministry registered the fenestrated anaconda ™ on the list of reimbursable products and services (lppr) by the french health insurance on february 2018 for a duration of 5 years, while taking up the conditions for carrying out the act recommended by the cnedimts (committee in charge of medical device review), namely the carrying out of a post-registration study for the renewal of the authorization. this renewal of registration is conditioned by the set-up of a long-term follow-up study of all patients treated with the fenestrated anaconda ™ in france. to do this, this study will be carried out in partnership with the federation of medical specialties (fsm) and the national professional council (cnp) of vascular surgery in order to have the data necessary for the renewal of the registration of the fenestrated anaconda ™ from the registry called datavasc developed by the cnp and available online on the fsm's electronic platform.

epi-efa study: post-registration study of the fenestrated anaconda™ in the management of a complex abdominal, juxtarenal, pararenal, suprarenal aortic aneurysm, whether or not associated with a distal common iliac artery or thoracoabdominal aneurysm type iv, in high-risk patients requiring treatment, for whom a surgical contraindication has been asked. * study type : observational, national, multi-centre, prospective, non-comparative study, as open registry * primary objective : to evaluate the long-term interest of fenestrated anaconda™ on all patients treated with in france. the data collected should be: * 1-year mortality rate related to device, procedure, any cause = primary endpoint * stent-related adverse events (endoleak, migration, integrity of the device), renal events, ischemia (medullary (paraplegia / paraparesis), intestinal) = secondary endpoints * study timelines : * duration / follow-up : * 1-year recruitment period from october 2019, with a minimum of 91 patients * mid-term follow-up : at 1 year * routine practice : until 5 years * reports to be submitted to french health authority : * interim report with mid-term follow-up data for renewal dossier * final report with long-term follow-up data

Eligibility criteria:
at the request of the french health authority (has), no inclusion or exclusion criteria can be set as the study should be carried out on all patients treated with the device in france.

Keywords: fevar fenestrated endovascular aaa custom device
talking pictures social media intervention in reducing depressive symptoms and improving spiritual well-being and quality of life in adolescent and young adult cancer patients

Conditions: Malignant Neoplasm

Summary: this clinical trial studies how well talking pictures social media intervention works in reducing depressive symptoms and improving spiritual well-being and quality of life in adolescent and young adult cancer patients. talking pictures social media intervention may help doctors better learn how to most effectively provide psychosocial support to adolescent and young adult cancer patients.

primary objectives: i. to determine the feasibility and acceptability of a 10-week application (app)-based intervention. ii. to assess the impact of the intervention on depressive symptoms, spiritual well-being and quality of life. iii. to examine the content of participants recorded narratives for salient themes related to weekly content areas (e.g. identity, meaning-making, hopes, fears) in order to better understand the unique experiences and challenges of adolescent and young adult (aya) patients. outline: participants undergo talking pictures social media intervention for 10 weeks, receiving weekly assignments via email with requirements to use the pixstori app to take and upload photographs with verbal narratives attached to a website. participants can then share their pixstories to a group page and view and respond to others' pixstories. after completion of study, participants are followed up at 2 months.

Eligibility criteria:
inclusion criteria: * adolescent and young adult cancer patients who were diagnosed within three years * english comprehension in written and oral format * current possession of a smartphone, tablet, or computer with camera and wifi capacity or data plan * valid email address * pregnant women will be included if they meet eligibility requirements exclusion criteria: * diagnosis of mental retardation, severe or untreated psychopathology (e.g. schizophrenia), or dementia * adults unable to consent: will not include * prisoners will not be included given lack of access to smartphone
treatment of depression in nursing homes

Conditions: Depression

Summary: this study will implement a treatment for depression in a nursing home setting.

depression in long-term care facilities is a significant public health issue. up to 50% of nursing home residents are affected by significant depressive symptoms. the decreased health and limited cognitive ability of many nursing home residents makes treatment and research extremely challenging. this study will attempt to identify and implement treatments for depressed nursing home residents. participants are randomly assigned to receive either an active intervention or treatment as usual for 6 weeks. the active intervention is followed by 4 weeks of maintenance. the intervention is implemented primarily by existing nursing facility staff and focuses on increasing opportunities for residents to experience pleasant events through increased levels of activity and positive affect. the maintenance treatment involves incorporation of protocol-based activities into patient care plans. patients have a follow-up visit 12 weeks after the study. psychiatric evaluations, depression and mood rating scales, observed affect and activity participation, behavior problems, and staff burden are assessed.

Eligibility criteria:
inclusion criteria: * nursing home residents * dsm-iv criteria for major depressive disorder or dysthymia or research diagnostic criteria for minor depressive disorder with current geriatric depression scale scores \> 11 and mini mental state scores \>= 14

Keywords: nursing homes aging
colorectal polyp resection adequacy

Conditions: Polyp Resection Adequacy

Summary: the purpose of this study is to determine the best way to ensure that polyps are completely removed by evaluating the borders of the removed polyp. if a polyp is found that meets the size requirements for the study, the investigators will take extra biopsies of the margin to determine if there is any abnormal tissue or cancer at these borders.


Eligibility criteria:
inclusion criteria: * age 40-80 exclusion criteria: * coagulopathy (international normalized ratio \>2) * inflammatory bowel disease or other active colitides * polyps of index colonoscopy that were felt not to be completely resected or pedunculated * familial adenomatous polyposis or hereditary polyposis * potential hereditary cancer syndrome (lynch syndrome)

Keywords: colorectal cancer screening colon cancer screening polyps colonoscopy
assessment of flow in cerebrospinal fluid shunts with a wireless thermal anisotropy measurement device in asymptomatic patients

Conditions: Hydrocephalus

Summary: this study evaluates the performance of the study device, flowsense®, a sensor for non-invasively assessing cerebrospinal fluid (csf) shunt flow. subjects with an existing implanted ventricular csf shunt will be evaluated with the study device in an outpatient setting to determine the negative predictive value (npv; part 1, blinded) and explore changes in surveillance imaging, health resource utilization, and visit duration during routine follow-up visits (part 2, unblinded).


Eligibility criteria:
inclusion criteria 1. existing ventricular cerebrospinal fluid shunt 2. age ≥ 2 years old 3. region of intact skin overlying an unambiguously identifiable palpable chronically indwelling ventricular shunt that crosses the clavicle; region of skin is appropriate in size for application of the study device 4. capable of providing informed consent or have a legal guardian, health care agent, or surrogate decision-maker able to provide informed consent 5. standard of care outpatient visit with neurosurgeon assessment of having "no clinical concern for shunt malfunction" exclusion criteria 1. subject not scheduled to receive outpatient standard of care imaging (ct, mri, x-ray shunt series) as part of the clinic visit 2. presence of more than one distal shunt catheter in the study device measurement region 3. presence of an interfering open wound or edema in the study device measurement region 4. subject-reported history of adverse skin reactions to silicone adhesives 5. participation in the study will interfere with, or be detrimental to, the administration of optimal health care to the subject 6. subject not available for seven-day follow-up