tumor staging t of bladder tumours: correlation of mri and anatomopathologic analysis

Conditions: Urinary Bladder Tumour; MRI; Invasion; Diagnosis

Summary: urinary bladder tumors with a frequency of 13000 new cases a year, have a heterogeneity in terms of survival according to the stage of local flooding. this is an aggressive tumor because of the potential muscular infiltration. it seems important in this case (muscular invasion), to increase the global survival. the anatomopathological analysis of the turb (biopsy bytrans-urethral resection of the bladder) is actually the gold standard for the pathology of bladder tumor. no need an imaging to discuss about the small and non muscular invasive tumor. but in most cases, the use is to perform at last an ultrasound or a ct-scan, specially for the invasive tumor. a lot of studies show that ct scan. is not the best way of investigation for the bladder muscle invasion. however, as in the prostate cancer with the pirads score, the mri can be useful for the bladder, thanks to the sequence improvement to the machine. the study from panebianco 2018, starts to talk about the mri in the urinary bladder cancer with new radiological terms. it creates a new score called virads score (as the pirads score already used for the prostate cancer). but it is never compared with the results of the turb. our study compares the results of the mri pre operative versus the pathology results on prospective analysis. main objective : t tumoral score in urinary bladder tumor : mri versus pathology results. secondary objectives : the contribution of diffusion weighted mri in the bladder neoplasm. type of study : interventional study, prospective, mono centric, single arm, intent-to-treat

this is a single center study comparing mri report to anatomopathological report in participants who were diagnosed with an urinary bladder tumour, histologically confirmed in routine care. bladder tumours are frequent pathologies with 13,000 new cases per year in france. they can present various types of damage, from the most benign to the most serious stages, depending on the number, the extent of the lesions and their degree of infiltration (superficial or deeper). we also know that the shorter the treatment time, the better the final prognosis. an infiltrating lesion taken as soon as it is discovered considerably reduces the likelihood of progression. it is therefore necessary to improve patient care. currently, when a bladder lesion is visualized by the urologist during the cystoscopy (examination during which the urologist notes the presence or absence of bladder lesion(s)), the only way to know its stage (and its degree of infiltration if applicable) which will determine the follow-up care, consists in carrying out an intervention called trans urethral resection of the bladder (turb), in order to remove the lesions which will be analyzed in the anatomopathological laboratory. this analysis is the best interpretation of the tumour stage, carried out in accordance with the international standards, and the only way to have a diagnosis of tumour lesions. indeed, to date, no imaging technique (ultrasound, scanner, etc.) makes it possible to obtain it. the ct scan of the urinary tract is currently only used to identify lesions of the upper urinary tract or lymph nodes. however, in recent years, these techniques have evolved considerably, and studies have shown that mri seems to have the ability to determine the tumour stage of bladder lesions. investigators propose to demonstrate the value of mri in determining tumour infiltration compared to the anatomopathological analysis of samples taken during turb. this would provide better patient care in human, pathological, economic and technical terms, by developing a more precise mapping of lesions in the bladder, reducing waiting times for results and therefore obtaining earlier diagnosis, a reduction in the number of consultations, hospitalizations, surgeries more or less morbid, examinations... finally, this would potentially : * reduce the number of cystoscopies (examination normally painless, but unpleasant and frequent) carried out before turb but also throughout the monitoring following the turb, * detect very early infiltrating lesions in order to limit their potential extension before the cystectomy.

Eligibility criteria:
inclusion criteria: * patient, male or female, aged \>18ans * benefiting from social security * urinary bladder tumour confirmed on cystoscopy and requiring a turb * understanding and reading french well * ability to give informed consent exclusion criteria: * participation refusal * mri contraindication : pacemaker, heart valve, clips, stents, coils, non-mri compatible defibrillators, neural or peripheral stimulator, cochlear implant, intraocular foreign body, claustrophobia * patient under guardianship, deprived of liberty, impaired understanding * pregnant/breastfeeding woman * allergy to gadolinium (contrast product necessary for carrying out the mri), hypersensitivity to gadoteric acid or gadolinated contrast products, to meglumine * suspicion of an infectious disease such as schistosomiasis (differential diagnosis) * patient presenting with macroscopic clotting hematuria on the day of the mri

Keywords: magnetic resonance imaging mri versus anatomopathology urinary bladder tumor mri diagnosis before turb (trans urethral resection of the bladder) nimbc (non invasive muscle bladder cancer)