evaluation of depolarization and repolarisation activity during cardiac arrhythmia using a novel monophasic action potential catheter

Conditions: Atrial Fibrillation; Ventricular Fibrillation; Junctional Tachycardia

Summary: monophasic action potential (map) recording plays an important role in a more direct view of human myocardial electrophysiology under both physiological and pathological conditions. the map method represents a very useful tool for an electrophysiological research in cardiology. its crucial importance lies in the fact that it enables the study of the action potential (ap) of myocardial cell in vivo and, therefore, the study of the dynamic relation of this potential with all the organism variables what can be particularly helpful in the case of arrhythmias. hundred and fifty patients will be included to explore mapping capabilities in cardiac chambers in patients suffering from regular or fibrillating tachycardia's with the following inclusion plan: i) atrial fibrillation at a total of 50 patients ii) ventricular fibrillation or patients at high risk of sudden cardiac death at a total of 50 patients iii) junctional tachycardia at a total of 50 patients. we will focus on cardiac activation (depolarization and repolarization) in this population.

this is a prospective descriptive study including 1 french centre the arrhythmogenic substrate that leads to fibrillating heart is poorly understood. this has hindered the development of methods for better understanding mechanisms. the development of better adapted tools to improve understanding and assessment of this substrate is crucial. the current electrophysiological study preceding the ablation is exclusively based on substrate depolarisation potential. it is very powerful when the arrhythmia is organized but limited during fibrillation due to incessant changes in activation. therefore, potentials of repolarization are better suited for the explorations of fibrillations because they provide basic properties such as refractory period and tissue heterogeneity in arrhythmia, but also in sinus rhythm. monophasic action potential catheters (map efa boston and map biosense webster) are available for many years and represent a very useful tool in cardiology in identifying critical areas to arrhythmias (mapping of depolarization and cardiac repolarization). however, their capacity to record action potential is limited because they have one electrode that allows "point-to-point" mapping by moving the catheter sequentially in the cardiac cavities. moreover, it is difficult to obtain one action potential due to the configuration or the angle of contact of the catheter with the cardiac wall. we want to evaluate a new map catheter (map4, medtronic) to assess cardiac depolarization and repolarization. this catheter was developed to allow recording of an action potential whenever the catheter touches the heart wall and whatever the configuration or contact angle. it appears identical to other catheters but is equipped with 4 spherical microelectrodes at its end. each microelectrode is arranged to one of the 4 'cardinal points' which allows easily simultaneous recording of 4 actions potential. hundred and fifty patients will be included to explore mapping capabilities in cardiac chambers in patients suffering from regular or fibrillating tachycardia's with the following inclusion plan: i) atrial fibrillation at a total of 50 patients ii) ventricular fibrillation or patients at high risk of sudden cardiac death at a total of 50 patients iii) junctional tachycardia at a total of 50 patients. we will focus on cardiac activation (depolarization and repolarization) in this population.

Eligibility criteria:
inclusion criteria: * patients with atrial fibrillation or ventricular fibrillation or junctional tachycardia or reentrant tachycardia * age ≥ 18 years old * signed patient informed consent form * affiliated to social security (european countries) exclusion criteria: * patients under 18 years old * pregnancy * psychiatric disorders * neurological sequelae after a prior cardiac arrest that prevents informed consent * absence of informed consent form

Keywords: depolarization, tissue repolarization, tissue cardiac arrhythmias action potentials, monophasic mapping, catheter cardiac activation