Kornimate/medical-research-clean huggingface dataset:
effectiveness of video based education versus music therapy on anxiety, experience, and co-operation among patients undergoing magnetic resonance imaging in radiology department at ilbs, new delhi.

Conditions: Effectiveness of Video Based Education Versus Music Therapy on Anxiety, Experience, and Co-operation Among Patients Undergoing Magnetic Resonance Imaging

Summary: a study to assess the effectiveness of video based education versus music therapy on anxiety, experience, and co-operation among patients undergoing magnetic resonance imaging. this is a experimental multiple interventions pre test - post test design. three groups namely, video based education group, music therapy group and control groups are there in study.there will be significant difference in the mean anxiety scores, experience level, and co-operation level of patients undergoing mri in video based education , music therapy group and control group


Eligibility criteria:
inclusion criteria: * undergoing mri with or without contrast * having age between 18- 60 years. * alert, oriented * able to comprehend, speak and listen english or hindi. * patients without hearing and visual impairment. * available during period of data collection exclusion criteria: * unconscious * critically ill and sedated. * visiting radiology department for other procedures such as computed tomography scan, and mri brain * having pain score of 3-10 on universal pain assessment scale..

Keywords: anxiety, video based education, music therapy, experience, cooperation, magnetic resonance imaging
hormonal and metabolic aspects of endoscopic sleeve gastroplasty

Conditions: Endoscopic Sleeve Gastroplasty; Laparoscopic Sleeve Gastrectomy; Gut Hormones; Glucose Metabolism Disorders

Summary: the investigators of the study want to investigate the complex interactions between glucose metabolism, food intake/weight loss, and different appetite regulating hormones after esg in comparison with conventional laparoscopic sleeve gastrectomy (lsg).


Eligibility criteria:
inclusion criteria: * age \> 18 years * scheduled for endoscopic or laparoscopic sleeve at hvidovre hospital * hba1c \< 48 mmol/mol before surgery, and no history of diabetes * hba1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion * bmi\<45 exclusion criteria: * hemoglobin \< 6.5 mmol/l at inclusion * pregnancy or breast feeding * medication affecting the planned examinations
self-help and education on the internet for functional motor disorders

Conditions: Functional Motor Disorder

Summary: a randomised trial to the effect of a newly developed education and self help intervention for patients with a functional motor disorder on general health, quality of life, illness perception, symptom severity and other secondary outcome measures.

patients will be referred to the study from all neurology centers in the netherlands that are found willing to participate. after informed consent is acquired, patients will be randomised into one of these two groups: usual care only or the education and self help intervention added to usual care. at baseline, after 3 months and after 6 months patients will fill out questionnaires at home online or on paper. patients will not be blinded for the intervention. the researcher is blinded during analysis of the data. during the study contact between the researcher and the participants will be restricted to research related topics. all contact between participants and the researcher will be documented. to increase generalisability and applicability in clinical practice after the trial the investigators have chosen to add the intervention to usual care and to keep exclusion criteria to a minimum. our education and self help internet intervention is an especially designed website with an educational approach. the content of the intervention is written by a team of international experts and consists of education about the mechanism of functional motor disorders and it's treatment and of self help advice and exercises. during the trial the website will only be accessible with a log-in. the education and self help internet intervention is self-explanatory and unguided. the medical ethical committee of the university medical center groningen has taken our research under review and has decided this study does not fall under the scope of the medical research involving human subjects act (wmo-wet mensgebonden onderzoek).

Eligibility criteria:
inclusion criteria: * diagnosis of functional motor symptom from a neurologist * the motor symptom(s) cause(s) distress or impairment in social, occupational or other important areas of functioning. * able to read dutch * access to a computer with internet connection on a regular basis exclusion criteria: * incapacitated (not able to provide informed consent) * accidental finding of a motor symptom in a patient with other (functional) complaints. * known existing visitor of the (previously available, but currently offline) translated version of a website by dr. jon stone

Keywords: self-help education e-health
study of autoimmune disease complications following ipilimumab treatment among melanoma patients with underlying autoimmune diseases

Conditions: Melanoma

Summary: the research questions to be addressed by this study are as follows: 1. what is the prevalence of ipilimumab use among adults with a history of autoimmune disease that received treatment with ipilimumab for advanced melanoma? 2. do melanoma patients with a history of autoimmune disease experience complications that require hospitalization related to their underlying autoimmune disease following treatment with ipilimumab?


Eligibility criteria:
inclusion criteria: * received ipilimumab therapy between 03/01/2011 and 6/30/2014 * aged 18 years or older at index date (initiation of ipilimumab) * diagnosed with melanoma before index * documented history of an autoimmune disease * have at least 6 months of continuous pharmaceutical and medical benefit enrollment prior to the index * have at least 3 months of continuous pharmaceutical and medical benefit enrollment following and including the index date exclusion criteria: * diagnosed with melanoma but no record of exposure to ipilimumab * no exposure to nivolumab (opdivo ®) at any time
acral cutaneous thrombotic vasculopathy and covid-19 infection

Conditions: COVID 19

Summary: spectrum of skin lesions may arise during covid-19 virus infection. it includes non-specific urticaria, aphtoids lesions, but also acrosyndromes, in particular suggestive of chilblains. pathological findings showed thrombocytic lymphocytic vasculitis. chilblains are sometimes associated with raynaud's phenomenon or acrocyanosis. dermatological features may present pathophysiological similarities with the inflammatory and respiratory vascular disturbances, which makes all the gravity of this disease, or even with other organs. indeed, genetic conditions such as familial lupus chilblains, linked to a mutation of trex1 gene, and savi (sting associated vasculopathy with onset on infancy) have similar clinical presentations. in particular, savi associates both acral skin and lung damage, and auto-antibodies. they have recently been identified as type i interferonopathies. hallmark is interferon signature, i.e. hyperexpression of type i interferon in the blood. the investigators hypothesize covid-19 may lead to similar skin involvement as in type i interferonopathies. the interferon pathway is involved in anti-viral defense. covid-19 could cause excessive activation of this pathway. in addition, hyperactivation of the type i interferon pathway leads to modulation of the adaptive immune response. production of autoantibodies, in particular antiphospholipid antibodies, have thrombogenic properties. searching for acquired hemostasis disorders and high level of interferon secondary covid-19 virus infection, could explain this new and misunderstood skin disorder. then, targeted therapies, both treating and preventing, could be considered.


Eligibility criteria:
inclusion criteria: * chilblains or vascular abnormalities (raynaud's phenomenon, purpura, livedo, necrosis, acrocyanosis) of the acral skin (hands, feet, nose, ears) developping during or after a proved or suspected covid-19 infection. exclusion criteria: * none

Keywords: suspected or proved covid-19 virus infection, current or past chilblains interferon vasculitis
adolescents with covid-19/mis-c at hcfmusp

Conditions: Covid19; Corona Virus Infection; SARS (Severe Acute Respiratory Syndrome); SARS-CoV Infection

Summary: this is a protocol aimed at children and adolescents contaminated with covid, treated at the hospital das clínicas, university of sao paulo, brazil (hcfmusp), in the recovery phase. the study aims to evaluate the spectrum of pathogenic lesions of the virus not only in the respiratory system, but digestive, immunological, neurological and others. clinical, evolutionary, laboratory and functional parameters will be used.

school-age children and adolescents covid-19 survivors may have persistent inflammation, a chronic course of covid-19, with isolated or concomitant aggressions of various organs and systems, making this disease a potential chronic condition, impacting aspects of quality of life related to health (hrqol), physical and mental health. in addition, pediatric covid-19 can induce autoimmunity (with the possibility of primary hypothyroidism and type i diabetes mellitus), delayed linear growth and delayed pubertal development, secondary immunodeficiency and present genetic polymorphisms in brain plasticity impacting rehabilitation. school-aged children and adolescents with covid-19 could present muscle weakness, dysautonomy, asthenia and physical inactivity, so it is essential that safe and effective interventions are developed to maintain adequate levels of physical activity and that they can be implemented on a large scale. however, to date, there are no systematic longitudinal studies that have evaluated all these aspects in a pediatric population that survived covid-19, particularly with chronic conditions and who were hospitalized in a tertiary service.

Eligibility criteria:
inclusion criteria: * school-age children and adolescents diagnosed with covid-19 exclusion criteria: * school-age children and adolescents with mis-c, who present: myocardial dysfunction, refractory cardiac arrhythmias, coronary artery aneurysms with or without thrombi, electrocardiographic alterations suggestive of myocardial infarction or ischemia and clinical signs of heart failure; * presence of any limitation or physical disability that prevents the practice of exercise; * pregnancy.

Keywords: covid19 children adolescents
a study of an ad26.rsv.pref-based regimen at the end of shelf-life in adults aged 60 to 75 years

Conditions: Respiratory Syncytial Virus Prevention

Summary: the purpose of this study is to demonstrate non-inferiority in terms of humoral immune responses of ad26.rsv.pref-based study vaccine lots representative of different aged vaccine in comparison to a non-aged ad26.rsv.pref-based study vaccine lot.


Eligibility criteria:
inclusion criteria: * before randomization, a participant must be: a) postmenopausal (postmenopausal state is defined as no menses for 12 months without an alternative medical cause); and b) not intending to conceive by any methods * from the time of vaccination through 3 months after vaccination, agrees not to donate blood * in the investigator's clinical judgment, a participant must be in stable health at the time of vaccination. participants may have underlying illnesses such as hypertension, congestive heart failure, chronic obstructive pulmonary disease, type 2 diabetes, hyperlipoproteinemia, or hypothyroidism, as long as their symptoms and signs are stable at the time of vaccination, and these conditions receive routine follow-up by the participant's healthcare provider. participants will be included on the basis of medical history and vital signs performed between informed consent form (icf) signature and vaccination * must be able to read, understand, and complete questionnaires in the electronic diary (ediary) * must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study * must be able to work with smartphones/tablets/computers exclusion criteria: * known or suspected allergy or history of anaphylaxis or other serious adverse reactions to vaccines or their excipients (including specifically the excipients of the study vaccine) * abnormal function of the immune system resulting from clinical conditions or medication * per medical history, participant has chronic active hepatitis b or hepatitis c infection * history of acute polyneuropathy (example, guillain-barré syndrome) or chronic idiopathic demyelinating polyneuropathy * has had major surgery (per the investigator's judgment) within 4 weeks before administration of the study vaccine or will not have recovered from surgery per the investigator's judgment at time of vaccination * has had major psychiatric illness and/or drug or alcohol abuse which in the investigator's opinion would compromise the participant's safety and/or compliance with the study procedures
probiotic chewables in allergic rhinoconjunctivitis patients

Conditions: Allergic Rhinoconjunctivitis

Summary: with this double- blind, randomised, placebo-controlled study, the investigators want to investigate the influence of a chewable with the probiotic strain lacticaseibacillus rhamnosus gg on the symptoms and immunological markers of allergic rhinoconjunctivitis (ar). in addition, the investigators aim to study the influence of this probiotic chewable on the microbiome of the upper respiratory tract after administration in adults with ar. the bacterial and cytokine profiles in the naso- and oropharynx will be monitored before, during and after the treatment.


Eligibility criteria:
inclusion criteria: * adults aged 18 at the time of registration; * seasonal allergic rhinoconjunctivitis (ar) in the context of grass pollen allergy diagnosed on the basis of anamnesis cfr. aria guidelines and positive skin prick test and / or immunocap assay; * positive skin prick test (spt) for grass pollen and / or the presence of specific ige for grass pollen, confirmed by a medical specialist, measured at the start of the study: soluprick sq phleum pratense pollen 10 hep - alk and / or ige specific immunocap assay phleum pratense (timothy grass) (g6); * body mass index in the range of 19-32 kg / m2; * instructed during screening and agreed not to use other probiotic products outside of the study during the study period; * signed the consent form. exclusion criteria: * antibiotic use at baseline and during the study; * pregnant women; * unstable / uncontrolled asthma (to be determined by investigator-physician); * sensitization to dust mites * history of probiotic use in the past two weeks; * current diagnosis of cancer or immunosuppressive therapy within the past 6 months; * abnormalities of the oral mucosa; * acute and chronic infectious and inflammatory upper airway diseases (eg acute / chronic rhinosinusitis cfr. epos guidelines); * clinically significant bleeding disorder; * any other medical condition that, in the principal investigator's opinion, warrants exclusion from the trial; * history of regular use (\> 3 days out of 7) of tobacco products within the previous two weeks

Keywords: lactobacilli microbiome probiotic chewables
improving signout accuracy and information delivery in the emergency department

Conditions: Medical Errors Related to Emergency Department Sign Out

Summary: the investigators sought to determine if implementing a standardized sign out process would reduce the amount of medical errors related to patient sign out. the standardized process included the following interventions: implementation of a data resident to review patients lab values, vital signs, radiologist results, and orders in real time, conducting sign out in a standardized location and using the attending physician as an "interruption manager." the investigators defined medical errors related to sign out as any piece of information was incorrectly reported or omitted during sign out that caused a change in treatment or disposition discussed during sign out. the investigators hypothesis was that implementing a standardized sign out process would lead to a decrease in the amount of sign out related errors.


Eligibility criteria:
inclusion criteria: * ed transfers of care occurring at 0700 or 1900. exclusion criteria: * attending only handovers (1500, 2300) * handovers including midlevel providers (thursday 0700, 1300).
cognitive impairment, obesity, and the effects of bariatric surgery

Conditions: Obesity, Morbid; Bariatric Surgery Candidate

Summary: study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.

patients with morbid obesity have shown to be at increased risk for memory loss and cognitive decline. obesity and high-fat diets have been associated with deficits in learning, memory, and executive functioning. bariatric surgery results in significant weight loss for patients and helps resolve obesity-related comorbidities such as diabetes and high blood pressure. interestingly, bariatric surgery has shown promise in improving some aspects of cognitive function and improved memory. (3-1) obesity affects brain structure, more specifically the grey and white matter, likely in part by reducing oxygen flow to the various regions in the brain. studies have shown a correlation between bmi and cerebral blood flow velocity (cbfv), where higher bmi is associated with lower cbfv. although it is not clear how exactly obesity plays a role in the brain's structural and functional changes, observations revealed compromised grey and white matter integrity, its fiber connectivity or cortical atrophy and metabolic alterations. (2) few studies exist on the impact of bariatric surgery on cognition. some studies have shown that patients with obesity who underwent bariatric surgery had memory and cognitive improvement compared to those who had not undergone surgery. (4) thus, the investigators hope to add to our understanding of how bariatric surgery can improve cognitive decline and to potentially offer surgery to more patients with baseline cognitive impairment and to improve cognitive function overall for patients with obesity. more longitudinal studies need to be done to connect bariatric surgery effects with cognitive decline, specifically memory.

Eligibility criteria:
inclusion criteria: * cognitive impairment/decline, memory impairment/loss, or alzheimer's disease or dementia and bariatric surgery • cognitive impairment/decline, memory impairment/loss, or alzheimer's disease or dementia and obesity, and no bariatric surgery history exclusion criteria: * patients without a history of memory impairment/loss, bariatric surgery, or obesity * patients outside of university of california davis health system * patients unable to provide consent

Keywords: obesity bariatric surgery cognitive screening
mindfulness, empathy and the oxytocinergic system in persons with schizophrenia

Conditions: Schizophrenia Spectrum and Other Psychotic Disorders

Summary: recent studies indicated positive effects of mindfulness-based interventions (mbi) for schizophrenia (scz), but also on oxytocin (oxt) levels in healthy persons. it was also shown that response to mbi could be shaped by genetic factors. however, the interplay between mindfulness and empathy and genetic factors with the oxytocinergic system has not yet been examined in scz. the aim of the current explorative study is to (1) explore the effect of mindfulness-based group therapy (mbgt) on oxt levels as well as empathy in persons with scz; (2) investigate whether polygenic risk scores (prs) for empathy can predict empathy levels in persons with scz; (3) investigate whether prs for empathy and specific genetic configurations in the oxytocin receptors are associated with mbgt outcomes and oxt levels; 4) examine changes in positive- and negative symptoms, depression, anxiety, social functioning, and mindfulness at a within-group level and between both conditions. a parallel-group, proof-of-concept randomized controlled trial with 30 participants allocated to each trial arm (n = 60) will be conducted. participants will be randomly assigned to mbgt alongside treatment as usual (mbgt+tau) or treatment as usual (tau). for a treatment period of four weeks, participants will receive weekly mbgt sessions. four weeks after baseline assessments (t0), post-intervention assessments (t1) will take place. as a pilot study, effect sizes will be estimated for within- and between-group effects with corresponding confidence intervals. outcomes of our proof-of-concept study can provide insight into potential biological mechanisms underlying mindfulness in scz, determine a valid biomarker associated with empathy and negative symptoms and pave the way for a personalized treatment approach for individuals with scz.


Eligibility criteria:
inclusion criteria: * be aged between 18 and 65 * meet diagnostic criteria for schizophrenia (icd-10: f20.x) ascertained by a trained psychiatrist * sufficient german language proficiency to engage with the intervention * no recent (\<4 weeks) major change in psychopharmacologic medication * be able to give written informed consent exclusion criteria: * a score of 7 on any item of the positive scale of panss, suggesting severe psychotic symptoms * acute suicidality * current substance use other than nicotine * neurological disorders or brain damages