Kornimate/medical-research-clean huggingface dataset:
does the intervention of an advanced practice nurse for nursing home residents aged 75 and over in the grand nancy area make it possible to reduce the use of the emergency service for these residents?

Conditions: Geriatric Health Services

Summary: the rate of emergency room visits is high at the extremes of age, with patients aged 75 or over accounting for 12% of emergency room visits, and the time they spend there is significantly longer than that of younger patients. nursing home residents represent 14% of these emergency room visits and only 5% of them on average are not hospitalised and return to their original nursing home. a retrospective study of patients aged 75 and over referred to the emergency department of the nancy hospital by the nursing homes over a six-month period showed that nearly 30% of patients aged 75 and over referred by their nursing home were rehospitalized during the period studied, 1/3 for the same reason and 2/3 for other reasons. the intervention of an advanced practice nurse (ipa) attached to geriatric practice, among other things, as an interface between nursing home and the hospital therefore seems to have its place in improving the care pathway for the elderly. the assessment by an advanced geriatric practice nurse of residents of nursing home aged 75 and over in grand nancy area one week after a visit to the emergency room significantly reduces the number of new visits to the emergency room by these residents over a follow-up period of seven months, compared with residents of nursing homes aged 75 and over (outside grand nancy area) who do not benefit from an assessment by an advanced practice nurse.


Eligibility criteria:
inclusion criteria: * person who has received full information on the organization of the research and has not objected to the use of this data * elderly men and women 75 years of age and older at the time of the emergency room visit * having for main residence one of the nursing homes * administratively present in the emergency department exclusion criteria: * people under 75 years of age * residing at home or in a senior residence * referred by an inpatient department (rehabilitation department)
evaluation of the effectiveness of daily pulse lavage therapy in chronic wounds

Conditions: Chronic Wounds

Summary: this study evaluates the effectiveness of pulse lavage therapy in decreasing bacterial counts in chronic wounds.

pulse lavage irrigation is an effective method of cleaning both acute and chronic wounds. the major drawback to pulse irrigation is that it is extremely messy and can easily contaminate the patient's surroundings, putting other patients and the person operating the device at risk. in order to obtain the benefits of pulse lavage, we have created a device that will contain the water spray from the lavage and protect both the patient and their surroundings. due to the fact that frequent (multiple times daily) pulse lavage therapy has not been possible previously, it is unknown how effectively serial pulse lavage irrigation reduces bacterial counts. this study evaluates the effectiveness of serial pulse lavage therapy in decreasing bacterial counts in chronic wounds.

Eligibility criteria:
inclusion criteria: 1. patients must have a chronic wound (as defined by the wound being present for \>30 days) located on any part of their body 2. the wound must be smaller than 10cm in greatest diameter. 3. patients must have an expected remaining hospital duration of 4 days 4. patients must be willing and able to comply with all study procedures exclusion criteria: 1. patients must not have undergone any surgical excisions or debridements of the wound in the past 30 days 2. the wound may not undergo any surgical procedures or other treatments other than the study treatments during the course of the study. 3. the wound may not require any immediate surgical intervention or debridement 4. patients may not start any new antibiotic therapy during the course of the study 5. must not have an allergy to skin adhesives. 6. patients must not be taking any immunosuppressive medications. 7. subjects who, in the opinion of the investigator, may not complete the study for any reason.

Keywords: chronic wound treatment pulse lavage serial pulse lavage wounds bacterial colonization of wounds
pedometer-based walking intervention on physical activity among hemodialysis patients

Conditions: Physical Inactivity; Fatigue

Summary: patients undergoing hd are mostly physically inactive and have reduced functional capacities compared to healthy individuals which contributes to a decreased quality of life and consequently increases the risk of mortality

physical activity has been shown to have various positive effects on hd patients . some of the important benefits linked to exercise include an improvement in physical fitness , aerobic capacity , dialysis adequacy (measured as urea kt/v) , quality of life , and reduced depressive symptoms .walking can be considered as the most natural form of pa as it is easily performed by everyone except for the seriously disabled or very frail. smartphones and their embedded computer technologies are increasingly being used to promote physical activity. gamification presents itself as a promising approach to overcome a loss of interest, increase user engagement , raise the quality of health behaviors , and motivate users to use mhealth apps for a sustained period

Eligibility criteria:
inclusion criteria: * inclusion criteria were 18 to less than 60 years of age, * under- going conventional hemodialysis three times a week, * hemodialysis period of three month or more, * having smartphone aneroid access (second group), * available for telephone follow-up , * ability to read and write , * and being ambulatory, * patients using a cane or other assistive device will be eligible and patients provided informed consent to participate. exclusion criteria: the study will exclude patients with * unstable angina, * those with lower-limb amputation * and those using wheelchairs.
a study to evaluate the efficacy and safety of alh-l1005 in patients with chronic periodontitis

Conditions: Chronic Periodontitis

Summary: the main objective of this study is to evaluate efficacy and safety of alh-l1005 in patients with chronic periodontitis


Eligibility criteria:
inclusion criteria: * men or women ages 18 and over, under 79 years of age * patients diagnosed with chronic periodontitis * patients with 4 teeth and over whose pocket depth is ≥ 4 mm and clinical attachment level is ≥ 3 mm * patients who are voluntarily participated in clinical trial exclusion criteria: * history of antibiotic therapy within the 1 month prior to study * those who had undergone any dental surgical or non-surgical therapy within 3 months prior to the start of the study * subjects who are pregnant/ lactating * smokers * patients who take anticoagulants or antiplatelet agents * with systemic diseases that affect periodontal conditions such as: diabetes, hypertension and diseases of immune system

Keywords: periodontitis
effect of anesthesia technique on early outcome in diabetic patients undergoing lower extremity amputation

Conditions: Diabetic Foot

Summary: the aim of this study was to compare 1. early prognosis (mortality, morbidity) 2. changes in concentrations of serum syndecan-1,partial pressure of oxygen(on arterial blood gas analysis), perioperative transfusion, intraoperative vasopressor use between general anesthesia and nerve block in diabetic patients undergoing limb amputation surgery as a prospective randomized trial.


Eligibility criteria:
inclusion criteria: * 1. patients undergoing diabetic foot limb amputation. * 2. patients aged 20 or older and who meet american society of anesthesiologists (asa) physical class 3-4 exclusion criteria: * 1. patients with dementia or cognitive impairment * 2. patients who had previously undergone diabetic foot limb amputation within 1 month. * 3. if the subject includes a person who can not read the written consent (eg, illiterate, foreigner, etc.) * 4. pregnant or lactating women * 5. contraindications to nerve block (infection of the injection site, no cooperation, patient rejection, history of allergy ro local anesthetics) * 6. relative contraindications to general anesthesia (if difficult airways are expected, history of malignant hyperthermia, moderate or severe asthma)
inspiratory muscle training in allogeneic hematopoietic stem cell transplantation recipients

Conditions: Allogeneic Hematopoietic Stem Cell Transplantation

Summary: allogeneic hematopoietic stem cell transplantation (allo-hsct) causes various toxic effects in many body tissues, organs and systems such as immune, cardiovascular, pulmonary, gastrointestinal, neuroendocrine and musculoskeletal systems, liver, kidneys and skin.available limited numbers of studies showed that inspiratory muscle weakness in allo-hsct candidates and recipients. although meta-analysis, systematic reviews and studies demonstrated beneficial effects of inspiratory muscle training on several outcomes in different disease groups; chronic obstructive pulmonary disease, bronchiectasis and heart failure, no published paper reported the effects of imt in allo-hsc recipients.

thirty-eight allo-hsct recipients (˃100 days past post-transplant status) were included. before and after 6-week imt, maximal and submaximal exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, dyspnea and fatigue perception, depression and quality of life were evaluated. primary outcome measurement was respiratory muscle strength, secondary outcomes were exercise capacity, dyspnea, peripheral muscle strength, quality of life, fatigue and depression.

Eligibility criteria:
inclusion criteria: * allo-hsc recipients (˃100 days past post-transplant status), * 18-65 years of age, * under standard medications exclusion criteria: * having cognitive disorder, orthopedic problem or neurological disease that were affecting functional capacity, * additional heart and lung diseases such as asthma, chronic obstructive pulmonary disease, acute infections or pneumonia, * problems prevented performing assessment and training such as visual problems and mucositis

Keywords: allogeneic hsct, inspiratory muscle training, exercise capacity
the in vitro fertilization - lipiodol uterine bathing effect study

Conditions: Endometriosis; In Vitro Fertilization Implantation Failure

Summary: the hypothesis of this study is that lipiodol uterine bathing improves the success rate of in vitro fertilization (ivf) for women with endometriosis or recurrent ivf implantation failure.


Eligibility criteria:
inclusion criteria: * 12 or more months infertility * age 18 to 39 * endometriosis or recurrent ivf implantation failure * patent fallopian tubes exclusion criteria: * iodine allergy * blocked fallopian tube or tubes

Keywords: recurrent ivf implantation failure
physician-patient communication and expectations regarding ovarian cancer prognosis

Conditions: Ovarian Cancer

Summary: the primary objective is to administer a cross-sectional survey to directly compare the differences patients and physicians hold regarding ovarian cancer prognosis and survival, complications arising from treatment, and counseling on advance directives, living wills, palliative care, and hospice services. overall, the project will pinpoint opportunities for better patient physician communication regarding prognosis and end-of-life care and allow for more informed and tailored decision-making.


Eligibility criteria:
inclusion criteria: * women over 18 years old with biopsy-confirmed malignancy * being actively treated or are in surveillance for epithelial ovarian cancer * have an existing therapeutic relationship with a provider who is participating in the study. exclusion criteria: * patients enrolled in palliative or hospice care programs, patients with a second primary malignancy within the last five years (excluding non-melanoma skin cancer) * patients who are illiterate or non-english speaking, and patients without decision-making capacity. * there are no exclusion criteria based on age, gender, economic status or race/ethnicity
smoke inhalation injury in patients admitted to intensive care

Conditions: Smoke Inhalation Injury; Morality

Summary: many studies have shown that the smoke-inhalation injury is responsible for a high mortality mainly related to the systemic effects of carbon monoxide and cyanide. respiratory lesions induced by smoke inhalation, is one of predictive factors of mortality. the aim of the study is to identify the clinical and epidemiological characteristics of smoke-inhalation injury and to identify prognostic factors among these patients .

the study is a monocentric, retrospective, descriptive and analytical study , betwen december 1997 and september 2018 in intensive care unit of university of hospital. all patients aged over 18 year and who had received a diagnosis of smoke- inhalation injury and were admitted to the icu of medical university hospital , a referral center in paris providing hbo therapy , were potentially eligible for inclusion in this investigation. criteria used for recommending hbo therapy to a patient with transient or prolonged unconsciousness, abnormal neurologic findings on physical examination. data were analyzed to identify independent factors that may influence mortality.

Eligibility criteria:
inclusion criteria * men or women over the age of 18 * hyperbaric oxygen therapy between 1997 and 2018 exclusion criteria * patients under 18 years old. * patient opposed to the use of his data * patients not treated with hyperbaric oxygen

Keywords: prognostic factors intensive care unit
intensive trauma treatment for children exposed to parental conflict

Conditions: Conflict, Interparental; Trauma, Psychological

Summary: the purpose of this study is to track outcomes of the investigator's therapy approach with children of separation/divorce who have been exposed to parental conflict.


Eligibility criteria:
inclusion criteria: * child between the ages of 6 - 16 * parent concerned re child's distress and behaviors related to custody, visitation, etc. * parent has the legal authority to obtain treatment for the child * parent and child fluent in english exclusion criteria: * as per clinical judgment of the pi during a telephone screening (interview of the referring parent), determination that the child is unlikely to be responsive to the intensive therapy format. this would typically be due to the child having a severe intellectual impairment, major dissociative disorder, etc.
comparison of hf10 therapy combined with cmm to cmm alone in the treatment of non-surgical refractory back pain

Conditions: Back Pain

Summary: this study is being conducted to document the safety, clinical effectiveness and cost-effectiveness of high-frequency scs at 10 khz (hf10™ therapy) delivered through the senza system in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. this study is a multi-center, prospective, randomized study to compare the two treatment groups.


Eligibility criteria:
key inclusion criteria: 1. have been diagnosed with chronic, refractory axial low back pain with a neuropathic component and are not eligible for spine surgery 2. have not had any surgery for back or leg pain, or any surgery resulting in back or leg pain 3. qualifying pain score 4. be on stable pain medications, as determined by the investigator 5. be willing and capable of giving informed consent 6. be willing and able to comply with study-related requirements, procedures, and visits 7. be capable of subjective evaluation, able to read and understand written questionnaires in the local language and are able to read, understand and sign the written inform consent key exclusion criteria: 1. have a diagnosed back condition with inflammatory causes of back pain, serious spinal pathology and/or neurological disorders 2. have a medical condition or pain in other area(s), not intended to be treated in this study 3. any diagnosis or known condition that can impact reporting of study outcomes as determined by the investigator 4. be benefitting within 30 days prior to enrollment from an interventional procedure to treat back and/or leg pain 5. have any addictions as determined by the investigator 6. have an existing drug pump and/or scs system or another active implantable device such as a pacemaker 7. have prior experience with neuromodulation devices 8. other general exclusions applicable for scs devices 9. be involved in an injury claim under current litigation 10. have a pending or approved worker's compensation claim
study of two fasting procedures before gastroscopy: 6 hours versus 2 hours for clear fluids

Conditions: Cirrhosis

Summary: upper gastrointestinal endoscopy is the key examination for screening for precancerous and cancerous lesions of the esophagus and stomach. this study aims to describe the quality of the visualization of the esophageal and gastric mucosa, the safety of use of two fasting procedures before gastroscopy and the feeling of patients. the population evaluated here concerns cirrhotic patients, at high risk of developing a precancerous lesion of the upper gastrointestinal tract. the investigator carries out a prospective, monocentric (besançon chru), interventional and randomized study according to two fasting procedures before gastroscopy: 6 hours (f6 group) versus 2 hours (f2 group) for clear fluids. the primary endpoint was to describe and compare the quality of visualization of the esophageal and gastric mucosa, graded from a (good quality) to c (poor quality) according to a score. developed by elvas et al. (endoscopy 2017).


Eligibility criteria:
inclusion criteria: * age \> 18 years, * male or female * cirrhosis based on radiological, clinical, biological or histological criteria exclusion criteria: * diabetes for more than 10 years; * under 18 years of age; * history of inhalation * patients in whom the gastrointestinal anatomy has not been retained * subjects who were unlikely to cooperate with the study and / or in whom poor cooperation was anticipated by the investigator * pregnant women patients taking drugs that may slow down gastric emptying such as: anticholinergic drugs, phenothiazines, antidepressants history of esophageal radiotherapy unsubstituted hypothyroidism

Keywords: cirrhosis upper digestive endoscopy fasting esophageal cancer superficial neoplastic lesions esophageal mucosa gastric mucosa
a registry study of shuxuening injection used in hospitals in china

Conditions: Coronary Disease; Intracranial Embolism; Stroke; Angina Pectoris; Vasospasm

Summary: the purpose of this study is get to know what and how shuxuening injection in hospital results in adverse events or adverse drug reactions from a cohort event monitoring.

ginkgo leaf is major component of shuxuening injection. although some western countries product similar injections and use them, shuxuening injection also regarded as chinese medicine injection. as a tcm injection, the most important thing is how to safety use it in practice. in order to improving monitoring adverse events or adverse drug reaction of chinese medicine injection in hospital, registry study is suitable method in this area. otherwise, nested case control study is used to find out the mechanism of allergic reaction. calculate the incidence of adverse events or adverse drug reaction is one of the main aims for this study. safety surveillance on chinese medicine injection is an important problem that needs to be sorted out through large sample observational study. according to the 'rule of three', 30,000 cases need to be registered at least. the aim population is who using shuxuening injection's during inpatient time from december 2012 to december 2014. data will be collected for three departments as following: form a (green): demographic information ；form b (pink): adverse drug events/reaction； form c (white): extracted information from hospital information system and laboratory information system.

Eligibility criteria:
inclusion criteria: * patients using shuxuening injection from 2012 to 2014 exclusion criteria: * none
evaluation of modified adhesives with dexcom g6 sensor

Conditions: Diabetes

Summary: the purpose of the study is to collect and compare information on the performance of cgm adhesives in adults.


Eligibility criteria:
inclusion criteria: 1. age 18 or older; 2. no previously self-reported adhesive reactions to the any continuous glucose monitor (cgm); exclusion criteria: 1. extensive skin changes/diseases that preclude wearing the required number of devices (e.g., history of severe reactions from adhesive wear, extensive psoriasis, recent burns or severe sunburn, extensive eczema, extensive scarring, extensive tattoos, dermatitis herpetiformis) at the proposed wear sites; 2. current or anticipated use of systemic corticosteroids (oral, injectable, or intravenous)

Keywords: diabetes continuous glucose monitoring systems
pregnancy-associated progression of chronic kidney disease: a study protocol for the development and validation of a clinical predictive tool

Conditions: Chronic Kidney Diseases; Pregnancy Related

Summary: to develop and validate a tool that estimates the degree of pregnancy-associated progression of renal disease in women with ckd and pregnancy outcomes in an international multicentre cohort study.

the aim of this study is to develop and validate a tool that estimates the degree of pregnancy-associated progression of renal disease in women with ckd and pregnancy outcomes in an international multicentre cohort study. two prediction models will be developed to estimate the likelihood of both outcomes. the models will be developed and internally validated in one cohort in the united kingdom and then externally validated using four international datasets.

Eligibility criteria:
inclusion criteria: * women with an estimated glomerular filtration rate (egfr) using the chronic kidney disease epidemiology collaboration (ckd-epi) without ethnicity adjustment, less than 90mls/min/1.73m2 within 24 months pre-conception will be included exclusion criteria: * women established on dialysis at time of conception * multi-fetal pregnancies * known inpatient egfr measurement * no preconception egfr within 24 months will be excluded.