Kornimate/medical-research-clean huggingface dataset:
evaluation of functional orthodontic treatment on sleep quality

Conditions: Sleep Apnea Syndromes in Children; Functional Orthodontic Treatment; Mandibular Retrognathia; Upper Airway

Summary: functional appliances are used in the treatment of class ii anomalies caused by mandibular rethrognathia. herbst which is a fixed and rigid functional appliance and twb which is removable appliance can be successful in the treatment of mandibular retrognathia in a short period of six to eight months during the pubertal growth phase. an increase in the upper airway size occurs as a result of functional orthopedic treatment devices eliminating the problem of mandibular retrognathia and stimulating mandibular growth. the aim of this randomized controlled trial was to evaluate the effects of twb and herbst appliances on sleep quality in children with obstructive sleep apnea. the null hypothesis was that there is no difference for the sleep quality between the appliances.

introduction: this multicenter clinical study aimed to investigate the effects of twin block (tb) and herbst functional appliances on sleep quality in children with osas and mandibular retrognathia. methods: a total of 46 patients having mandibular retrognathia and identified with osa were divided randomly into two groups: twin block (tb) and herbst functional appliances. changes in sleep parameters at baseline and an avarage of 8-month follow-up detected by polygraphy and pittsburg sleep quality index (psqi) were the primary outcome. treatment of the mandibular retrognathia was the secondary outcome. hapiro wilk test and q-q graphs were used to examine the distribution assumptions of continuous variables according to groups. mann whitney u test was used to evaluate two independent group means or distributions of continuous measurements. paired sample t test or wilcoxon signed rank test was used to evaluate the differences between the baseline and follow-up times at p \< 0.05 significance level.

Eligibility criteria:
inclusion criteria: * no prior orthodontic treatment, nasal, tonsillar, or adenoid surgery * absence of any oral, nasal or systemic disease * the existence of skeletal class ii and dental class ii division 1 malocclusion (anb \>4°; snb \ 3 mm) * requiring functional orthodontic treatment * individuals are in the mp3cap and s period according to hand-wrist films, and in the cs3 and cs4 period using the cvm method * patients with osa (apnea/hypopnea index (ahi)\>1/h exclusion criteria: * body mass index (bmi) ≥ 30 (weight (kg)/height (m2)) * the presence of nasopharyngeal pathologies, craniofacial anomalies, , systemic disorder, or weak oral hygiene * history of previous orthodontic treatment

Keywords: obstructive sleep apnea herbst twin block
kinematics and muscle strength in two, five or 10 years afther total hip arthroplasty

Conditions: Hip Osteoarthritis

Summary: introduction: femoral and acetabular replacement is characterized as total hip arthroplasty (tha). it has been used as treatment of various pathologies of this joint. in the postoperative period, some studies have shown that strength, function, range of motion and lower limb mechanics remains altered for more than one year after tha in relation to the non-operated side. however, studies that have correlated kinematics and hip muscle strength in individuals who underwent tha for long time, do not exist in literature. objective: to evaluate lower limb muscle strength and 2d kinematics during stair ascending and descending in patients undergoing total hip arthroplasty. methods: third individuals who underwent total hip arthroplasty (tha) will be recruited at two, five and 10 year postoperative periods. they were allocated in three groups: group 1 (10n), subjects submitted to tha for two years, group 2 (10n) subjects submitted to tha for five years, group 3 (10n) subjects submitted to tha for 10 years and group 4 (10n) subjects without orthopaedic afections, all will be evaluated for dynamometric isometric muscle strength and kinematic analysis of stair ascending and descending by a "blinded" physical therapist.


Eligibility criteria:
inclusion criteria: * the investigators will recruit 40 individuals who underwent total hip arthroplasty (tha) by the hospital hip surgery group in the periods of two, five and 10 years postoperatively * control group without orthopaedic afections. inclusion criteria: patients submitted to total hip arthroplasty between two years (24 months - 35 months), five years (60 months - 71 months) and 10 years (120 months - 131 months), aged between 50 and 80 years and sign the terms of free and informed consent exclusion criteria: * patients with a history of prosthesis dislocations or revision of arthroplasty * hip or lower limb pain * asymmetry of the lower limbs greater than two centimeters * previous surgeries in the lower limbs * limited range of motion in the hip joint * use of antidepressive drugs or analgesics for continuous use * presence of neuromuscular pathologies and functional incapacity to perform the activities proposed in the kinematics analysis.
evaluation of outcomes from treatment of benign or malignant pancreatic diseases

Conditions: Benign or Malignant Pancreatic Diseases

Summary: this study will be a retrospective chart review of patients who have been diagnosed with the benign or malignant pancreatic disease under the practice of dr. rohan jeyarajah, m.d., dr. houssam osman m.d., and dr. edward cho m.d., sc.m. at methodist health system hospital in richardson, tx. the investigators plan to conduct an analysis of patients meeting the inclusion criteria from 2005 to present. study will also be conducted by the pi, sub-is, surgery fellows, office staff and clinical research coordinator who are delegated to do by the pi. data will be obtained by looking through either investigator's patients or through a national database. data will be analyzed primarily by the study conductors.

it is reported in the literature that the treatment of any pancreatic disease process, whether benign or malignant, continues to be a huge challenge. for example, patients with adenocarcinoma continue to be diagnosed at an advanced stage with medical and surgical options that are improving in terms of outcome measurements but with much more room for improvement. the investigator's goal is to continue to review our treatment outcomes to further improve overall survival, overall symptom control, mortality, and morbidity. the main aim of this study is to evaluate and compare the outcomes from the investigator's decisions on multiple treatments of benign or malignant pancreatic diseases.there is a need to understand and improve the current diagnosis and treatment algorithm for pancreatic pathologies. continued evaluation and study is imperative to ensure that national guidelines are improving to enhance patient cure and/or recovery. all past patients who were treated for a particular benign or malignant pancreatic disease process under evaluation from 2005 to present will be included in this study.

Eligibility criteria:
inclusion criteria: * • all patients diagnosed and treated for pancreatic diseases, benign or malignant from 2005 to present * age ≥18 years exclusion criteria: * • patients that are not diagnosed with or treated for pancreatic diseases * age \< 18 years
a prospective randomized controlled clinical trial of standard versus goal-directed perioperative fluid management (gdt) for patients undergoing radical cystectomy

Conditions: Bladder Cancer

Summary: the purpose of this study is to help us learn what is the best amount of fluid to give to patients during bladder surgery in order to avoid delayed bowel function after surgery, which could prolong hospital stay.


Eligibility criteria:
inclusion criteria: * adults (21 years old or greater) who are able to provide informed consent * patients who undergo an open, elective radical cystectomy exclusion criteria: * patients with active atrial fibrillation or flutter, since the algorithm is not accurate in case of cardiac arrhythmia * female patients who are pregnant (female patients of child-bearing potential must have a negative serum pregnancy test ≤ 14 days prior to surgery or 15 to 30 days prior to surgery with a negative urine pregnancy test the morning of surgery) * presence of ascites, because increased abdominal pressure interferes with ev1000 reading accuracy * bmi \> 45 or \<17, because increased abdominal pressure interferes with ev1000 reading accuracy

Keywords: radical cystectomy perioperative fluid management ev1000 14-069
medication-overuse headache: 4 years follow up

Conditions: Medication Overuse Headache

Summary: from 1 january 2004 to 31 december 2006 64 individuals with probable medication overuse headache were included in a randomized, 1-year open-labeled, multicentre study to evaluate the effect of early introduction of prophylactic treatment compared to abrupt withdrawal and with a control group (clinicaltrials.gov number nct00159588). in this follow-up, randomized patients still alive 4 years after primary inclusion time will be invited to a follow up interview, evaluating the headache complaints and the proportion of recurrent medication overuse.

the participants will be interviewed by telephone or consult the study doctor completing a headache diary for at least 1 month before attending the visit.

Eligibility criteria:
inclusion criteria: * randomized during the initial trial during 2004-2006.

Keywords: headache medication overuse chronic relapse
non-interventional study (nis) to assess reaching of cholesterol target values in patients treated with hmg-coa reductase inhibitors

Conditions: Hypercholesterolaemia

Summary: this is a multi-centre non-interventional study of patients who are treated with any hmgcoa reductase inhibitor available in croatia (rosuvastatin, simvastatin, atorvastatin and fluvastatin) for at least 6 months. all hmg-coa reductase inhibitors must be prescribed in accordance with smpcs approved in croatia. data collection for each patient will take place at a single visit. the investigator will complete a case report form with the patient's demographics, the presence of the factors for high cardiovascular risk, current treatment, cholesterol values as well as with further treatment decision.


Eligibility criteria:
inclusion criteria: * patients who have been treated with one hmg-coa reductase inhibitor for at least 6 months without changing the dose for the last 4 weeks at least. * all patients must sign informed consent form. exclusion criteria: * patients who have not signed the informed consent form. * patients with contraindication for the treatment with hmg-coa reductase inhibitors as per smpc approved in croatia.

Keywords: cholesterol hmg-coa reductase inhibitor cardiovascular risk ldll
assessing the feasibility of n-of-1 trials in children with hypertension and chronic kidney disease

Conditions: Hypertension; Chronic Kidney Diseases

Summary: the purpose of this study to test whether n-of-1 trial-guided clinical decision-making improves blood pressure control in hypertensive children with chronic kidney disease (ckd) and end-stage renal disease (esrd).


Eligibility criteria:
inclusion criteria: * hypertension * ckd stage 2-5 * requiring antihypertensive medication per clinician judgement. exclusion criteria: * renal transplant anticipated or occurred within 6 months of screening * transfer out of our practice setting anticipated within 6 months * unable to complete 24 hour arterial blood pressure monitoring (abpm) due to developmental or behavioral limitations

Keywords: n-of-1 trial
pilot study of the impact of exercise on hippocampal function

Conditions: Anxiety

Summary: the goal of this pilot study is to test the procedural aspects of the behavioral tests and the exercise components of the study. this includes establishing typical scores for anxiety patients in these behavioral tests, and administering and coaching anxiety patients in an at-home exercise regimen. this pilot study will produce the information necessary to design a larger future study including both patients and healthy control participants.

this is a pilot study to explore whether high intensity interval training (hiit) aerobic exercise can improve performance on hippocampal dependent behaviors or anxiety measures . hiit is a form of interval training that alternates short periods of high effort exercise with less intense recovery periods. participants in this study will undertake a 6-week protocol of hiit exercise, performed at home on a portable stepper device. outcome measures for this study will be performance on two hippocampus-dependent behaviors and responses to mood and anxiety questionnaires. the hippocampus is a brain structure that is involved in learning and memory, and is one of the two sites of adult neurogenesis, the process of generating of new neurons from stem cells in the adult mammalian brain. adult neurogenesis may represent a new target for the treatment of anxiety disorders. the tests in this study consist of a picture-based memory task and a location memory task. eligible participants will complete both game tasks. in each test, participants will sit in front of a computer and play these games using the computer keyboard or a handheld video game controller.

Eligibility criteria:
inclusion criteria: * a primary diagnosis of obsessive compulsive disorder (ocd), social anxiety disorder (sad), generalized anxiety disorder (gad), panic disorder (pd), and/or specific phobia (sp) * no use of psychiatric medication in the past 4 weeks (or 8 weeks for fluoxetine) * age 18-40 * ability to tolerate a treatment-free period * english-speaking * body mass index (bmi) within normal range * willing and able to sign consent form and comply with study procedures exclusion criteria: * current or lifetime comorbid psychiatric conditions that significantly elevate the risk of study participation * any major medical or neurological problem that might interfere with reliable performance of study tasks or their interpretation, or render participation dangerous * pregnant or lactating * use of medication that alters the brain * clinical symptom severity warranting immediate treatment * current rigorous exercise program * participation in cognitive behavioral therapy (cbt) psychotherapy for anxiety

Keywords: neurogenesis memory spatial processing hippocampus cognition aerobic exercise
investigating the experience of living with down syndrome and obstructive sleep apnea syndrome (stage 1)

Conditions: Down Syndrome; Obstructive Sleep Apnea

Summary: to identify the perceptions, beliefs, and family-relevant outcomes regarding the treatment of obstructive sleep apnea syndrome (osas) with positive airway pressure (pap) in children with down's syndrome (ds).

this is a multi-center outpatient study to be performed at two clinical sites: children's hospital of philadelphia and cincinnati children's hospital. forty caregivers of children with ds and osas treated with pap and their children will be enrolled. the study comprises one 30-minute open-ended semi-structured interview per caregiver. the duration of the interview is approximate. it will last up to 30 minutes as some families may want to include more details.

Eligibility criteria:
inclusion criteria -- patients * children with ds and osas treated with pap for at least 6 months * children aged between 6 and 17.5 years * english proficiency inclusion criteria -- caregivers * parent or legal guardian of an eligible patient subject * english proficiency * must live with the patient subject at least 4 nights of the week exclusion criteria -- patients * in foster care * diagnosed with major illness, such as leukemia or severe cyanotic congenital heart disease listed for cardiac transplant as these severe diseases may add confounders exclusion criteria -- caregivers * foster parent

Keywords: down syndrome obstructive sleep apnea
investigating the influence of omeprazole on the pharmacokinetics of oral semaglutide in healthy subjects

Conditions: Diabetes; Healthy

Summary: this trial is conducted in europe. the aim of this trial is to investigate the influence of omeprazole on the pharmacokinetics (the exposure of the trial drug in the body) of oral semaglutide in healthy subjects.


Eligibility criteria:
inclusion criteria: * male or female age 18-75 years (both inclusive) at time of signing informed consent * body mass index of 18.5-29.9 kg/m\^2 (both inclusive) * a good general health based on medical history, physical examination, and results of vital signs, electrocardiogram and laboratory safety tests performed during the screening visit, as judged by the investigator exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive methods. female of child bearing potential must use effective methods of birth control for the duration of the trial and for 5 weeks following last dose. only highly effective methods of birth control are accepted (i.e., one that results in a less than 1% per year failure rate when used consistently and correctly, such as implants, injectables, combined oral contraceptives, and some intrauterine devices) * history of crohn's disease, ulcerative colitis, or other inflammatory bowel disease * hypertension (defined as sitting systolic blood pressure above or equal to 140 mmhg and/or diastolic blood pressure above or equal to 90 mmhg). if white-coat hypertension is suspected at the screening visit a repeated measurement is allowed * any blood draw in excess of 25 ml in the past month, or donation of blood or plasma in excess of 400 ml within the 3 months preceding screening
urine cadmium levels in predicting pancreatic cancer risk in patients with chronic pancreatitis

Conditions: Pancreatic Cancer; Precancerous Condition

Summary: rationale: measuring cadmium levels in urine samples from patients with chronic pancreatitis may help doctors predict which patients may develop pancreatic cancer. it may also help the study of cancer in the future. purpose: this clinical trial is studying urine cadmium levels in predicting pancreatic cancer risk in patients with chronic pancreatitis.

objectives: primary * obtain urine samples and questionnaire data on cadmium exposure in patients with chronic pancreatitis. * analyze these data to determine risk of pancreatic cancer using urine cadmium levels. secondary * analyze these data in conjunction with data on serum ca 19-9, to determine whether urinary cadmium has clinical utility in predicting pancreatic cancer. * determine the sensitivity, specificity, and positive and negative predictive values for the cadmium test alone, ca 19-9 alone, and both tests together. outline: this is a pilot study. patients complete a questionnaire over approximately 20 minutes on lifetime exposure to cadmium, including dietary, occupational, and recreational exposure, smoking history, and residence. patients also provide a urine sample that is analyzed by atomic absorption spectrophotometry. serum ca 19-9 levels are obtained from medical record if available.

Eligibility criteria:
disease characteristics: * clinical diagnosis of chronic pancreatitis * being seen in the department of gastroenterology at wake forest university baptist medical center patient characteristics: * no type ii diabetes * able to understand and respond to questionnaire * able to provide urine specimen * speaks english prior concurrent therapy: * not specified

Keywords: pancreatic cancer precancerous condition
behavioral and neuroimaging changes after cognitive rehab in traumatic brain injuries (tbi) and mild cognitive impairment (mci)

Conditions: Mild Cognitive Impairment; Alzheimer's Disease; Traumatic Brain Injury

Summary: memory deficits are common after traumatic brain injuries (tbi) and are characteristic of various forms of dementia, such as alzheimer's disease and its common precursor mild cognitive impairment (mci). this project intends to assess the efficacy of cognitive rehabilitation in these patient populations. we will also use neuroimaging (functional magnetic resonance imaging - fmri) to assess changes in brain activity that occur following cognitive rehabilitation.


Eligibility criteria:
inclusion criteria: general inclusion criteria (all patients): * a minimum of 12 years of education or attainment of a graduation equivalency diploma; * all medications stable for approximately 3 months; * no history of severe mental illness; * no current untreated alcohol or substance abuse/dependence; * english as native and preferred language; * mri-compatible if taking part in fmri studies 7) able to give informed consent. mci inclusion criteria: * diagnosis of amnestic mci based on criteria set forth by petersen (2004). additionally, other potential causes of cognitive deficit ruled out by the referring physician; * 55 years of age or older. tbi inclusion criteria: * history of a mild to moderate tbi; * no history of other neurological disease or injury; * a minimum of 6 months and maximum of 5 years post-onset of tbi; * 18 - 45 years old. exclusion criteria: * history of neurological disease or injury (other than tbi) * history of severe mental illness * current untreated alcohol or substance abuse * other conditions may exclude; please discuss with contact

Keywords: cognitive rehabilitation explicit memory training mild cognitive impairment alzheimer's disease traumatic brain injury veterans
m-health administered sleep treatment to enhance recovery in bariatric populations (master)

Conditions: Insomnia; Morbid Obesity

Summary: this study is a longitudinal clinical trial designed to assess the feasibility of sleep intervention (cognitive behavioral therapy for insomnia (cbt-i)) in individuals with insomnia following bariatric surgery.


Eligibility criteria:
inclusion criteria: * age 18-64 * fluency with english * willingness to maintain an active telehealth platform account * daily access to wireless internet connection or sufficient cell phone service for telemedicine * undergone bariatric surgery (roux-en-y or vertical sleeve gastrectomy) within past 1-3 years * must have experienced \ 11) exclusion criteria: * patient underwent revision of initial weight loss procedure * phq-9 depression score \> 15 * gad-7 anxiety score \> 15 * current alcohol or substance abuse * current narcotic use * unstable major psychiatric condition * restless leg syndrome * sleep apnea with non-adherence to cpap intervention (i.e., use of cpap \<4 nights/week) * other problems at investigator discretion * vulnerable populations (e.g., adults unable to consent, ages \<18, pregnant women, and prisoners).

Keywords: insomnia sleep bariatric surgery morbid obesity