Kornimate/medical-research-clean huggingface dataset:
investigation of the perfusion of gluteal muscle in patients with intermittent gluteal claudication by non-invasive msot

Conditions: Peripheral Vascular Diseases; Peripheral Arterial Disease; Intermittent Claudication; Gluteal Claudication

Summary: the objective of the proposed study is to define independent parameters for the diagnostic assessment of the perfusion situation of the gluteal muscle based on multispectral optoacoustic tomography (msot) in patients with gluteal claudication in fontaine stage ii (intermittent claudication) pre and post-intervention.

this is a monocentric, prospective study which aims to exanimate the optoacoustic signals in gluteal muscle after a exercise in patients with pad in fontaine stage ii before and after the revascularisation to verify the change of msot by improved vascularization. msot data will be correlated with ccds, abi, treadmill test, subjectively perceived absolute walking distance in everyday life, pad-related life quality (vascuqol-6) and tasc ii classification in angiographic imaging (only in case angiographic imaging is available and independent from this study). patients with gluteal claudication in fontaine stage ii will be recruited during the consulting hours of the department of vascular surgery, university hospital erlangen. following detailed information about the study and after providing written consent, relevant clinical data will be collected from the electronical patient file, if available. in addition, a thorough anamnesis interview for relevant data and ccds would be performed. afterwards, the msot parameters will be recorded on gluteal muscles before and after a stepper exercise two minutes or until the occurrence of claudication pain in the gluteal muscle. the more affected side is examined. all data will be adequately pseudonymized in compliance with data protection regulations before they are used for statistical analysis. the duration of the study for participants will be max. 90 minutes. the angiographic imaging will be reviewed and analyzed.

Eligibility criteria:
inclusion criteria: • patient with gluteal claudication in fontaine stage ii and corresponding stenosis (common iliac artery, internal iliac artery or distal aorta) exclusion criteria: * patients with pad in fontaine stage i, iii and iv or rutherford category 0, 4, 5 and 6 or healthy volunteers with diabetes mellitus, chronic renal failure, claudication symptoms, abnormal abi or non-palpable foot pulses * people with age under 18 * absence of written consent * safety concerns of the study physician (person with physical, mental or psychiatric conditions which, by the judgement of the study physician, would compromise the person's safety or the quality of the data, thereby rendering the person an ineligible candidate for the study

Keywords: peripheral vascular diseases peripheral arterial disease peripheral artery disease pad gluteal claudication buttock claudication msot multispectral optoacoustic tomography
analgesia in laparoscopic cholecystectomy

Conditions: Pain, Postoperative; Chronic Postoperative Pain

Summary: the investigators hypothesis is that perioperative infusion of 0.75 ropivacaine in patients undergoing laparoscopic cholecystectomy may modify the intensity of postoperative pain or the analgesic consumption during the first 24 hours.

patients scheduled for laparoscopic cholecystectomy were randomly assigned to receive via a subcutaneous catheter 2 ml per hour of 0.75 ropivacaine or same volume of normal saline. the catheter was inserted after induction of general anesthesia and before beginning of surgery and continued for the first 24 postoperative hours. the solutions were administered by means of an elastomeric pump. before induction of anesthesia metoclopramide 10 mg, ranitidine 50 mg and droperidol 0.75 mg were given intravenously. in the operating room the routine monitoring was applied. anesthesia was induced with thiopental 5-6 mg/kg, fentanyl 2 μg/kg, and rocuronium 0.6 mg/kg, and maintained with sevoflurane 1-1.5 minimum alveolar concentration (mac) in a nitrous oxide/oxygen mixture. after induction of anesthesia diclofenac 75 mg i.v was given within 30 min. before wound closure each hole was infiltrated with 2 ml of ropivacaine 0.75 or normal saline. at the end of surgery neuromuscular block was reversed with sugammadex 2 mg/kg., the patient was extubated and transferred to the post-anesthesia care unit (pacu). intra-operatively, the intra-abdominal pressure, the rate of carbon dioxide insufflation and the total amount of carbon dioxide insufflated are recorded every 5 minutes. besides the ropivacaine infusion in the operative site, postoperative analgesia is assured in the pacu with paracetamol 1 gr and tramadol 100 mg if visual analogue scale (vas) score is above 40 mm.in the ward lonarid tablets are given instead. vas values and analgesic consumption are recorded in the pacu, and 2, 4, 8, 24 and 48 hours after surgery. the catheter is removed 24 hours after surgery. one and three months after surgery patients are interviewed by phone for the presence of pain due to surgery.

Eligibility criteria:
inclusion criteria: * patients aged 30-70 years american society of anesthesiology (asa) physical status i-iii * scheduled for laparoscopic cholecystectomy exclusion criteria: * patients with chronic pain and/or on analgesics for the last month, * patients with central nervous, kidney and liver disease, or allergy to local anesthetics

Keywords: acute postoperative pain late pain chronic pain wound irrigation with local anesthetic
mind body syndrome therapy for chronic pain

Conditions: Chronic Pain; Chronic Pain Syndrome

Summary: the goal of this study is to determine if a mind-body intervention can help people suffering from chronic back pain. the study is a randomized, partially blinded trial examining the effectiveness of a mind body intervention in reducing disability from back pain and alleviating back pain in participants as compared to usual care and an active control (second mind body intervention). the investigators will secondarily investigate whether the intervention alleviates anxiety related to the pain and other quality of life parameters.

the goal of this study is to determine if a mind-body intervention can help people suffering from chronic back pain. the study is a randomized, partially blinded trial examining the effectiveness of a mind body intervention in reducing disability from back pain and alleviating back pain in participants as compared to usual care (control arm) and an active control arm. the investigators will secondarily investigate whether the intervention alleviates anxiety related to the pain and other quality of life parameters.

Eligibility criteria:
inclusion criteria: * adult patient 18 ≥ years old * chronic back pain * pain persistent for a minimum of 3 days a week for the past three months prior to enrollment * willingness to consider mind-body intervention * at least score of 2 or more on roland disability questionnaire * at least score of 3 or more back pain bothersomeness exclusion criteria: * patients \< 18 years of age * patients \> 67 years of age * diagnosed organic disease as cause of pain, such as (but not limited) to malignancy, neurologic disorder (i.e., amyotrophic lateral sclerosis), cauda equina syndrome (note that pain related to disc disease is not an exclusion unless there are neurological impairments) * patients with a diagnosis of significant psychiatric co-morbidities such as schizophrenia, dementia, and bipolar disorder
cognitive behavioural therapy for children with autism spectrum disorder and obsessive compulsive behaviour

Conditions: Autism Spectrum Disorder; Obsessive-Compulsive Behavior

Summary: individuals with high functioning autism spectrum disorder (asd) frequently experience obsessions and/or compulsions that are similar to those specified in diagnostic and statistical manual of mental disorders (5th ed.; dsm-5) criteria for obsessive compulsive disorder (ocd). however, little research exists on effective interventions for ocd symptoms (referred to as ocbs) in asd. in a randomized controlled trial, a manualized functional behavior-based cognitive-behavior therapy (fb-cbt) consisting of traditional cbt components (psychoeducation and mapping, cognitive-behavioral skills training, exposure, and response prevention) as well as function-based behavioral assessment will be evaluated. participants will be assigned randomly to fb-cbt or treatment as usual (tau). primary and secondary outcome measures will be used to evaluate the efficacy of the treatment, and will be administered at pre and post-intervention as well as six month follow-up.


Eligibility criteria:
inclusion criteria: * previous diagnosis of asd * presence of ocbs as defined by sameness, ritualistic and compulsive subscales on the rbs-r * a full scale iq (wisc-iv; wechsler, 2004) ≥ 70 * parent indicated no planned change in child medication during the study (unless the physician deemed the change medically necessary) exclusion criteria: * participation in treatment for anxiety * participation in treatment for repetitive behaviour * participation in treatment for intensive behavioural intervention

Keywords: cognitive behavioral therapy
3d or 2d upper extremity exergaming for persons with parkinson's disease

Conditions: Parkinson Disease

Summary: a pilot study with the "10cubes" for small and precise movements and training in the virtual environment will be carried out. we will recruit at least 20 persons with parkinson's disease to participate in the study. such activities can increase participation, slow down the progress of the disease and contribute to the functional improvements of the hand that lead to the increased quality of life. the movement of the hand will be assessed with a small 3d camera, also suitable for the estimation of kinematic parameters. participants will be randomized into 2 groups; one group using an lcd screen and the other using 3d goggles (oculus rift cv1) enabling them to carry out the task in virtual environment. both groups will take 10 training sessions within 2 weeks. their task will be collecting 10 virtual cubes one-by-one and putting them in the virtual treasure box. clinical tests (box and blocks test and motor part of the updrs) will be carried out in the clinical settings prior and after the training sessions. we hypothesise that the different feedback equipment may provide different results.

the participants will practise grab and grasp in virtual environment (ve), either on a laptop computer or using 3d goggles. they will sit in a comfortable chair, with a small camera tracking the hand and finger movements of their affected (dominant, in case of both hands affected) hand. the participant will grab any of the virtual cubes lying around the ve and put it in the treasure box. when the cube falls into the treasure box it disappears and the participant scores, one by one until the 10th cube or 120s of time elapse. the cubes will be randomly spread in the ve and will all have the same virtual size, weight and bouncing factor, but different colour. if the participant is left-handed, the treasure box will be mirrored to the right side. if the cube is pushed into the floor, it disappears without a score and is lost. each participant will take 10 consecutive training sessions in 2 weeks, each session lasting for 30min. within a session, the participant will take 5 trials, with breaks of 1-2 min between them.

Eligibility criteria:
inclusion criteria: * parkinson's disease diagnosis * minor problems with daily activities and upper extremities * hoehn and yahr scale level 2-3 exclusion criteria: * insufficient cognitive and motor abilities to carry out the exergaming task

Keywords: exergaming physiotherapy upper extremities telerehabilitation
monocytosis and culprit vessel in stemi patients

Conditions: STEMI

Summary: increased white blood cell count at the onset of an acute st elevation myocardial infarction has been shown to be associated of increased incidence of heart failure and mortality. now monocytes which are a subset of white blood cells may have a prognostic value for patients presenting with acute st segment elevation myocardial infarction. a monocyte count of greater than 800/mm3 following acute myocardial infarction has been shown to be associated with increased incidence of left ventricular dysfunction. the investigators study would retrospectively collect data on patients with st elevation myocardial infarction, looking for an association between high monocyte count and the culprit vessel causing the myocardial infarction. the investigators would also investigate whether monocytosis would be a marker of poor prognosis.


Eligibility criteria:
inclusion criteria: * stemi exclusion criteria: * patients on antibiotics and steroids

Keywords: monocytes culprit vessels
an assessment of aspirin plus prednisone treatment for euthyroid women with thyroid autoimmunity

Conditions: Thyroid Diseases

Summary: thyroid autoimmunity(tai) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ata) positive infertile women in clinical practice, but the impact of these medicines is still controversial. therefore, aim of the study was to investigate whether or not the treatment of prednisone in addition to aspirin was capable of improving reproductive outcomes in euthyroid infertile women.

a multicenter retrospective study performed during the period of 2017 to 2020 and euthyroid infertile women positive for anti-thyroperoxidase antibody (tpoab) and/or thyroglobulin antibody (tgab) alone with thyroid stimulating hormone 0.35-4.0miu/l undergoing first in vitro fertilization and embryo transfer(ivf-et) cycle were recruited in our study.data analysis was performed using the statistics package for social sciences.in the end, the value of prednisone plus aspirin treatment was investigated to make a big contribution on clinical practice.

Eligibility criteria:
inclusion criteria: 1. both tpoab and tgab in all the subjects were measured before art procedure 2. thyroid stimulating hormone (tsh) level ranged from 0.35-4.0miu/l 3. women underwent first embryo transfer without previous ivf history. exclusion criteria: 1. abnormal thyroid function test 2. women with known autoimmune diseases or clinical presentations of autoimmune disorders

Keywords: prednisolone assisted reproductive technology aspirin thyroid diseases
frequency and risk factors of congestive heart failure in dialysis patients

Conditions: Congestive Heart Failure

Summary: this study aims : to assess the frequency of heart failure in patients with end-stage renal disease on regular dialysis. to identify the risk factors of heart failure in patients with end-stage renal disease. to assess the impact of duration of dialysis on heart failure and its prognosis

heart failure is defined as a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood with diagnosis relying on clinical examination and associated with significant mortality and morbidity. congestive heart failure (chf) is a cardiovascular complication in which the heart becomes unable to supply a sufficient amount of blood to meet the metabolic requirements and fulfill the body's oxygen demand. chf is an independent risk factor for early mortality in esrd patients. more than half of all deaths among esrd patients are due to cardiovascular disease (cvd). cardiovascular changes secondary to renal dysfunction, including fluid overload, uremic cardiomyopathy, secondary hyperparathyroidism, anemia, altered lipid metabolism, and accumulation of gut microbiota-derived uremic toxins like trimethylamine n-oxidase (tmao), contribute to the high risk for cvd in the esrd population. also, conventional hemodialysis (hd) itself poses myocardial stress and injury to the already compromised cardiovascular system in uremic patients. the characteristics of cardiovascular dysfunction observed in dialysis patients are distinct from those noted in the general population. although traditional cardiovascular risk factors in patients with end-stage renal disease (esrd) are highly prevalent, they play only a partial role in the excessive cardiovascular morbidity and mortality of this population. the paradoxical association between several traditional risk factors, such as body mass index, blood pressure (bp) and serum cholesterol, and mortality have been previously reported. in the esrd population, hemodialysis (hd) contributes itself to the development of chf with sustained fluid overload a major cause of hypertension, heart failure, and mortality in patients with esrd. we postulate that repeated myocardial micro-injury during maintenance hemodialysis may lead to irreversible cardiac dysfunction and subsequent heart failure and death in some patients.

Eligibility criteria:
inclusion criteria: * esrd patient on regular hemodialysis exclusion criteria: * aki patients on hd * patients discontinued therapy during the study period will be excluded. * patients with structural heart disease (congenital or valvular heart disease) * patients with obstructive or restrictive lung diseases.
diabetic retinopathy and visual function study

Conditions: Diabetic Retinopathy; Macular Degeneration; Vision, Subnormal

Summary: the purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. the visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. the evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. photoreceptor-mediated visual loss will be assessed by measurements of the stiles-crawford effect. visual loss mediated by post-receptoral retinal changes will be assessed by measuring the westheimer spatial desensitization/sensitization effect.

the purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. the visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. the evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. photoreceptor-mediated visual loss will be assessed by measurements of the stiles-crawford effect. visual loss mediated by post-receptoral retinal changes will be assessed by measuring the westheimer spatial desensitization/sensitization effect.

Eligibility criteria:
patients with diabetic retinopathy that has not been previously treated are eligible for the study. patients who have had laser photocoagulation (either focal or scatter) are not eligible.

Keywords: diabetic macular edema diabetic retinopathy macular edema photocoagulation psychophysical testing stiles-crawford effect
an observational study on evaluating the efficacy and safety of preemptive antiviral therapy with tenofovir in hbsag-positive patients with diffuse large b-cell lymphoma receiving rituximab-chop chemotherapy (speed study)

Conditions: B-cell Lymphoma

Summary: an observational study on evaluating the efficacy and safety of preemptive antiviral therapy with tenofovir in hbsag-positive patients with diffuse large b-cell lymphoma receiving rituximab-chop chemotherapy (speed study)


Eligibility criteria:
inclusion criteria: * males or females aged more than18 * hbsag-positive dlbcl patients (it is possible to enrol the patients with combined dlbcl and low grade lymphoma such as follicular lymphoma) * previously untreated dlbcl patients who are suitable for receiving r-chop chemotherapy * serum alt no more than 2 x uln (including normal alt) * life expectancy 6 months * a negative serum or urine pregnancy test prior to treatment must be available both for pre menopausal women and for women who are no more than 1 years after the onset of menopause. * informed consent exclusion criteria: * other subtype of lymphoma except dlbcl * dlbcl patients who are not suitable for receiving r-chop chemotherapy or plan to receive other chemotherapy * patients had been treated with antiviral therapy known to have activity against hbv (e.g., alpha-interferon, lamivudine, telbivudine, clevudine, adefovir, entecavir or tenofovir) within the previous 6 months. * evidence of hepatocellular carcinoma. * evidence of decompensated liver disease
a prospective, multi-center study to evaluate the efficacy and safety of vitamin d3 b.o.n. intramuscular injection in adults with vitamin d deficiency

Conditions: Vitamin D Deficiency

Summary: to compare the efficacy of vitamin d3 b.o.n. intramuscular injection within 12 weeks with that of placebo in adults with vitamin d deficiency.


Eligibility criteria:
inclusion criteria: * subjects with vitamin d deficiency exclusion criteria: * subjects who experienced a hypersensitivity to the cholecalciferol * subjects with renal impairment * subjects with hypercalcemia * subjects with hypercalciuria * subjects with clinically doubted calcium stone * subjects diagnosed with sarcoidosis * subjected diagnosed with pseudo-hypoparathyroidism * subjected with malignancy * subjects with clinically significant cardiovascular or lung impairment judged by the investigator * subjects with the below laboratory abnormality (platelet, wbc, absolute neutrophil count, albumin, ast or alt) * subjects who are to take vitamin d supplements during the study period
dysphagia awareness in medical and nursing students

Conditions: Dysphagia; Awareness; Students

Summary: a survey consisting of questions about swallowing and dysphagia was provided to universities' medicine and nursing students. the answers of students were analyzed

the undergraduate training of health care professionals may provide the necessary theoretical and practical approach to future nurses and physicians. this study was planned to investigate students' dysphagia knowledge level and awareness in the medicine and nursing faculties. a survey consisting of questions about swallowing and dysphagia was provided to universities' medicine and nursing students. the answers of students were analyzed

Eligibility criteria:
inclusion criteria: * the fourth, fifth, and sixth-grade students in the faculty of medicine * the second, third, and fourth-grade students in the nursing faculty exclusion criteria: * the first, second and third-grade students in the faculty of medicine * the first grade students in the nursing faculty

Keywords: dysphagia awareness medical students nursing students