Kornimate/medical-research-clean huggingface dataset:
hostility and coronary risk--role of weak vagal function

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia

Summary: to determine whether deficient vagal antagonism of sympathetic nervous system (sns) actions on the heart contributed to increased coronary heart disease risk in hostile persons.

design narrative: sophisticated electrophysiologic monitoring approaches were used to: 1) show greater sensitivity in nonhostile young men to t-wave attenuation effects of isoproterenol infusion following vagal blockade; 2) show that vagal enhancement reduced and shortened the t-wave attenuation effects of isoproterenol infusion more in hostile young men; 3) evaluate these effects of vagal blockage and enhancement in middle-aged men and in young and middle-aged women; and 4) relate the t-wave effects in these studies to other measures of vagal tone and other biobehavioral mechanisms of coronary-prone behavior. four studies were conducted in normal young and middle-aged men and women selected as high and low on hostility, evaluating vagal tone measures and effects of isoproterenol infusion on ekg t-wave and st response after pretreatment with saline, neostigmine, and atropine. demonstration that hostility was associated with deficient vagal anatagonism of sns effects on the heart, especially in middle-aged as compared to younger persons, suggested that diminished vagal tone was one pathway whereby high hostility contributed to increased chd risk. clinical studies were then conducted to determine whether weaker vagal tone predicted increased myocardial ischemia and/or poorer outcomes in coronary heart disease patients. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
compare the analgesic effect of different anesthesia and postoperative analgesic methods in uniportal vats lung surgery

Conditions: Postoperative Pain; Single-incision Thoracoscopic Surgery

Summary: this is a single center, randomized, single blind study to compare the analgesic effect of different anesthesia and postoperative analgesic methods in uniportal vats lung surgery.

combining epidural with general anesthesia is regarded as the gold standard of general thoracic surgery. the uniportal vats lung surgery have advantages of minimal invasive surgical incision, less postoperative pain, and so on. whether general anesthesia can become an alternative method of combining epidural with general anesthesia in uniportal vats lung surgery, investigators thus plan to make a comparison on intraoperative stress response, postoperative pain, immune function of patients，and hospital expenses.

Eligibility criteria:
inclusion criteria: * patients elective uniportal vats lung surgery; * bmi 18-30 kg/m2. exclusion criteria: * patient refuse; * asa≥3; * patients allergic to use anesthetics (propofol,rocuronium), patients with liver and/or kidney and/or mental dysfunction.
the effects of the novel "step up your game" program on men's lacrosse

Conditions: Body Weight Changes

Summary: for the purpose of this pilot study, the investigators hypothesize that the use of the step up your game protocol will result in statistically significant improvements in health and athletic performance. the key to this is the coordination of resources from a supervising physician, physical therapist, trainer, dietitian, coach, competitor, role model, psychologist, and spiritual leader. notably, step up your game provides resources which would allow patients to find or be their own physical therapist, trainer, dietitian, coach, competitor, role model, psychologist, and spiritual leader. the role of the supervising physician, however, is meant for a qualified professional, who follows the osteopathic approach to medicine, in which the body is treated as an integrated whole, while also working to prevent and treat injuries. though not limited solely to osteopathic physicians, it is critical to take into account every health aim and injury in the context of the athlete and how these affect all aspects of participants lives.


Eligibility criteria:
inclusion criteria: * individuals capable of giving consent between ages of 18 and 22. * must be members of the nyit lacrosse team. exclusion criteria: * individuals who are not able to participate throughout the season whether it's due to a medical problem or academic probation. * individuals who are receiving sports related medical care other than that from the physician in study.
myofascial pain:acupuncture versus trigger point injection combined with dipyrone and cyclobenzaprine

Conditions: Myofascial Pain Syndromes

Summary: context and objective: myofascial syndrome is the most frequent condition of chronic pain. the objective of the present study was to compare the analgesic action of acupuncture and trigger point injection combined with cyclobenzaprine and dipyrone. design and setting: a randomized study was performed at the pain clinic. methods: thirty patients were divided into two groups: g1 received trigger point injection of 0.25% bupivacaine (1 ml/point) twice a week, 10 mg/day cyclobenzaprine and 500 mg dipyrone every 8 h. g2 was submitted to classical and trigger point acupuncture twice a week. the patients were asked to continue physical exercise. the following parameters were evaluated: pain intensity rated on a numerical and verbal scale, quality of life before and four weeks after treatment, and quality of analgesia.

among the 39 patients selected, nine (3 in group 1 and 6 in group 2) were excluded from the study because they did not attend the visits scheduled for the procedures and assessment or because they did not respond to the questionnaires.

Eligibility criteria:
inclusion criteria:- patients of both genders * chronic myofascial syndrome (duration of more than three months), * ranging in age from 18 to 65 year, * pain intensity score of 3 or higher (rated on a numerical scale ranging from 0 to 10) exclusion criteria: * patients with disc herniation, * osteoarthritis, * vertebral collapse, * temporomandibular joint dysfunction, * infection, - * tumors, * coagulopathy, - * psychiatric disease, * cognitive disorders. * patients who had used any type of analgesic or muscle relaxant agent 15 days before the study and those taking anticoagulants

Keywords: myofascial pain syndrome acupuncture nonsteroidal anti-inflammatory agents muscle relaxants, central quality of life. muscle relaxants, analgesia
prospects for the prevention of pregnancy-induced hypertension and preeclampsia trial

Conditions: Pregnancy Induced Hypertension

Summary: hypertensive disorders of pregnancy (hdp) are with 50.000 deaths every year one of the major causes of maternal mortality worldwide, especially in low and middle income countries. this trial aims to determine whether a daily dose of combined low-dose aspirin, calcium, vitamin d3, folic acid and vitamin b12 in pregnancy reduces the incidence of pregnancy-induced hypertension in women at risk. secondary and tertiary objectives include other maternal and neonatal outcomes.


Eligibility criteria:
inclusion criteria: * \<16 weeks of gestation and over 18 years of age, * intention to have subsequent antenatal visits and delivery at the same clinic. * can receive text messages by phone or through the phone of a proxy. * a moderate to high risk (\>20%) of developing pih exclusion criteria: * pre-existing hypertension or hypertension before 20 weeks gestation. * likely non-compliance with the protocol in view of the treating physician * comorbidity interfering with the protocol * known contraindications to investigational product components

Keywords: pregnancy induced hypertension gestational hypertension pre-eclampsia preeclampsia hypertensive disorders in pregnancy
ultrafast ultrasonographic oro-laryngeal measurement in critically ill patients during weaning from mechanical ventilation

Conditions: Laryngeal Edema

Summary: in icu, ventilatory weaning failure is common, accounting for up to 25% of extubations. these failures are largely due to swallowing disorders and laryngeal edema. edema prevalence in icu varies between 4 and 37%. post-extubation stridor is a clinical sign of upper airway obstruction and may require urgent reintubation, which is associated with increased patient length of stay, morbidity and mortality. identifying patients at risk is critical, and the need for reliable tools to predict the occurence of laryngeal edema is still relevant.


Eligibility criteria:
inclusion criteria: * adults, * intubated and ventilated for more than 24h, * filing mechanical ventilation weaning criteria. exclusion criteria: * pregnant of breast-feeding woman, * under guardianship patient, * history of laryngeal tumor, stroke, paralysis of recurrent nerve, swallowing disorders, * history of surgical laryngeal intervention or radiotherapy, * unplanned extubation, * opposition to take part in the study.

Keywords: post-extubation stridor intensive care unit ultrafast ultrasonography
dysphagia evaluation after stroke- effect oral neuromuscular training on swallowing dysfunction

Conditions: Dysphagia; Stroke

Summary: the aim of this study is to investigate the effect of a specific rehabilitation program with an oral device used in stroke patients with persistent oral-and pharyngeal dysphagia.

this study aims to investigate the effect of oral neuromuscular training in stroke patients with persistent oral- and pharyngeal dysphagia 12 (±3) weeks after stroke onset. interventional study with probe-design (prospective randomized open-label blinded evaluator). consecutive patients with first-ever stroke without previously known dysphagia with persistent dysphagia (doss\<6) at 3 months (12±3 weeks) post-stroke onset. patients are eligible to participate if they are admitted to one of the following seven hospitals/centers in sweden: umeå university hospital, danderyds hospital, södersjukhuset, skaraborg hospital (skövde), helsingborg hospital, halland hospital, kungälv hospital, kalix hospital, skellefteå hospital, and ellenbogen in malmö. further centers will be recruited. exclusion criteria: unable/unwilling to give informed consent or to cooperate. randomization will be made web-based 1:1 by use of the developed redcap system with stratification for center and aspiration (yes/no). in total, 336 stroke patients (168 intervention group; 168 control group) with persistent dysphagia 12(±3) weeks after stroke onset will be included in the present study. the intervention group will be offered to undergo oral neuromuscular training alongside routine care with compensatory training for 3 months. the control group will only be offered routine care with compensatory training for 3 months. the participants' status regarding swallowing function, nutritional status, quality of life related to swallowing, pneumonia, functional status including lip force, and death will be assessed before and after the completed intervention period, and 6 months post-intervention. the primary endpoint will be analyzed using an ordinal regression (proportional odds) model, adjusting for baseline doss as well as for the stratifying variables center and aspiration. the investigators hypothesize that swallowing intervention with oral neuromuscular training is more effective than routine care rehabilitation.

Eligibility criteria:
inclusion criteria: * persistent dysphagia 12(±3) weeks after stroke. exclusion criteria: * stroke patients with neurologic or psychiatric disorders or other diseases/conditions that can affect swallowing function. * unable to collaborate due to other serious diseases and/or to affected general condition.

Keywords: dysphagia stroke intervention oral neuromuscular training randomized control trial
multifactorial intervention on cardiovascular risk factors in subjects with peripheral arterial disease

Conditions: Peripheral Arterial Disease; Hypercholesterolemia; Hypertension; Diabetes Mellitus; Smoking

Summary: the purpose of this study was to evaluate whether an intensified multifactorial intervention program about cardiovascular risk factors in subjects with peripheral arterial disease (with and without diabetes mellitus), can improve the control of these factors (mainly hypercholesterolemia and hypertension) in relation to the habitual care

subjects with peripheral arterial disease show an increased cardiovascular risk. it is thought that improving control of cardiovascular risk factors (hypercholesterolemia, hypertension, diabetes, smoking) could be beneficial in reducing their cardiovascular risk. however, usual care of these subjects (mainly at primary care) is not associated with an optimal control of such cardiovascular risk factors. we hypothesise that an intensive multifactorial treatment in a cardiovascular risk unit could improve control of these cardiovascular risk factors. to test this hypothesis we perform a controlled, randomized, open, parallel trial. subjects are recruited at the vascular surgery unit and are randomised into two groups: 1. usual care (control group); 2. intensive care (intervention group). randomization is stratified for the presence/absence of diabetes mellitus and with the use of sealed envelopes. patients assigned to receive usual care (general practitioner with the possibility of being referred to specialists) are compared to those assigned to undergo intensive multifactorial intervention. this intervention involves strict treatment goals (ldl-cholesterol \< 100 mg/dl, blood pressure \< 130/80, hba1c \< 7 %, no smoking) to be achieved through behavior modification (diet, physical activity, smoking cessation) and a stepwise introduction of pharmacologic therapy for hypercholesterolemia, hypertension and diabetes. this multifactorial intervention is overseen by a multidisciplinary team (endocrinologist, nurse, and dietitian) at the hospital of sabadell (corporación parc taulí). the treatment goals are the same for the usual care group and general practitioners caring patients included in this study are informed of these strict treatment goals. patients in the intensive-therapy receive 6 scheduled individual consultations in one year (baseline and 2,4, 6 and 9 months after their inclusion).primary and secondary outcomes are evaluated at 12 months after their inclusion.

Eligibility criteria:
inclusion criteria: * arm-ankle index \ 0.40 in at least one leg exclusion criteria: * advanced peripheral arterial disease (arm-ankle index \< 0.40 or amputation) * peripheral arterial disease of non-atherosclerotic origin (e.g. vasculitis) * heart failure (nyha iii or iv) * end-stage renal disease * atrial fibrillation * active peptic ulcer disease * blood coagulation disorders * platelets disorders * cancer * history of rhabdomyolysis * treatment with immunosuppressant agents (e.g. cyclosporine, glucocorticoids) * excessive intake of alcohol (\> 280 gr/week) * institutionalized patients
haip combined with fuquinitinib as late-line treatment in patients with crlm：a phase 2 single-arm clinical trial

Conditions: Colorectal Neoplasms

Summary: this study was a phase 2, single-arm, single-center clinical trial in which previously treated patients with unresectable colorectal cancer liver metastases.

the aim of this study is to evaluate the safety and efficacy of hepatic arterial infusion pump chemotherapy combined with fruquintinib in later treatment for colorectal cancer liver metastases. all patients received folfoxiri-haip chemotherapy and oral fruquintinib. the primary end point was objective response rate (orr), and the secondary endpoints were disease control rate (dcr), the liver-specific orr, overall survival (os), progression-free survival (pfs), liver-specific pfs, and safety.

Eligibility criteria:
inclusion criteria: * age between 18 and 75 years; * eastern cooperative oncology group performance status (ecog ps) score of 0 to 2; * prior treatment with chemotherapy based on oxaliplatin, fluorouracil, and irinotecan, with or without egfr or vegfr monoclonal antibodies; * at least one measurable intrahepatic target lesion according to recist v1.1 criteria * normal major organ function exclusion criteria: * previous treatment with transarterial chemoembolization (tace) or haic;2) prior use of fruquintinib * presence of other systemic primary malignancies, excluding colorectal cancer * allergy to the study drug;5) severe dysfunction of major organs (liver, kidney, heart, or lungs)
comparison of tumor glucose metabolism before and after artificial nutrition

Conditions: Head and Neck Cancer; Oesophageal Cancer

Summary: evaluate the feasability to determine the difference of tumoral metabolism before and after artificial nutrition.

evaluation of the feasability to determine the difference of tumoral metabolism before and after artificial nutrition. this activity will be measured with tep/tdm 18f-fdg

Eligibility criteria:
inclusion criteria: * vads cancer or oesophageal cancer * evaluation by 18f-fdg pet * denutrition with weight loss of 5% * artificial nutrition * ecog\<2 exclusion criteria: * treatment by chemotherapy, surgery unless 2 months * treatment by radiotherapy unless 4 months * capillar glycemia \>12mmol/l during the pet

Keywords: denutrition in head and neck cancer or oesophageal cancer
alternative stress management approaches in hiv disease

Conditions: HIV Infections

Summary: the overall purpose of the proposed study is to determine whether three short-term stress management interventions along with booster strategies will improve and sustain improvements in psychosocial functioning, quality of life, and somatic health among persons with varying stages of hiv disease. the 10-week group interventions are designed to reduce perceived stress and increase coping effectiveness and include cognitive-behavioral stress management focused on positively living (+live), focused tai chi (tchi) training, and spiritual growth groups (sprt). effects of the interventions will be evaluated immediately upon completion of the group training and at 6 months and 12 months following stress management training.

the overall purpose of the proposed study is to determine whether three short-term stress management interventions along with booster strategies will improve and sustain improvements in the domains of psychosocial functioning, quality of life, and somatic health among persons with varying stages of hiv disease. these three outcome domains, along with neuroendocrine mediation, will be measured by multiple indicators derived from the psychoneuroimmunology (pni)paradigm. the interventions are designed to reduce perceived stress and increase coping effectiveness and include cognitive-behavioral stress management focused on positively living (+live), focused tai chi (tchi) training, and spiritual growth groups (sprt). the primary aim of this randomized clinical trial is to compare the +live, tchi, and sprt interventions to each other and to standard care received by a control group of wait-listed participants (wait) for effects on psychosocial functioning (perceived stress, coping patterns, social support, psychological distress), quality of life (including spiritual well-being), neuroendocrine mediation (cortisol, dhea levels), and somatic health (disease progression, hiv-specific health status, immune status).

Eligibility criteria:
inclusion criteria: * aware of hiv-infected diagnosis exclusion criteria: * current psychoactive drug use * severe and unstable psychiatric diagnosis * major cognitive dysfunction

Keywords: behavioral intervention psychoneuroimmunology complementary therapy stress and coping complementary therapies
labetalol to prevent hypertension and tachycardia during fiberoptic bronchoscopy

Conditions: Bronchoscopy

Summary: passing a bronchoscope through the airways frequently causes a stress response even though patients are sedated. this stress response is usually an increase in pulse and blood pressure, which may have undesirable effects on the heart and circulation. we plan to give patients labetalol (a beta blocker which reduces pulse and blood pressure) in addition to normal sedation, to patients undergoing bronchoscopy in our department.


Eligibility criteria:
inclusion criteria: * all patients over 18 years old undergo fiberoptic bronchoscopy in our unit exclusion criteria: * inability or refusal to give informed consent * bronchoscopy through an artificial airway * intolerance or allergy to the study drug * bradycardia (hr\<60/min) or hypotension (systolic bp \<100) at screening * pregnancy, * concomitant treatment with diltiazem or verapamil * intention to use propofol as the sedative agent for bronchoscopy.
effectiveness study of hydrotherapy against pain and other symptoms in diabetes-induced lead

Conditions: Diabetes; Lower Extremity Arterial Disease

Summary: the purpose of the study is to investigate whether the hydrotherapy are effective in against pain and other symptoms in diabetes-induced lead.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2 diabetes mellitus * diagnosis of lower extremity arterial disease exclusion criteria: * severe heart disease * can't hydrotherapy

Keywords: hydrotherapy randomized controlled trial lower extremity arterial disease diabetes
sopran - omeprazole treatment versus surgery

Conditions: GERD

Summary: the purpose of this study is to study gastritis, gi symptoms during long term omeprazole treatment


Eligibility criteria:
inclusion criteria: * previous inclusion into astra study i-635 and willing to continue for another 10 years, exclusion criteria: * pregnancy or lactation; woman planning pregnancy within 5 years; suspected or confirmed malignancy; documented eradication of helicobacter pylori.

Keywords: maintenance of healed erosive esophagitis