Kornimate/medical-research-clean huggingface dataset:
the prevalence of ctx disorder in juvenile cataract cases in turkey

Conditions: Cerebrotendinous Xanthomatosis

Summary: epidemiologic observational study. study will include two phases: 1. retrospective cross-sectional phase: at this stage of the study, retrospective screenings are carried out at study sites and all juvenile cataract cases are planned to be determined. 2. prospective phase: at this stage of the study, identified juvenile cataract cases as a result of retrospective screenings will be called to be invited to the sites and blood samples will be obtained for the cholestanol tests for the cases that have given informed consent. this observational study is designed in two phases; retrospective and prospective. retrospective part includes screening the patient database and / or patient files at ophthalmology clinics participating in the study and identifying patients diagnosed with idiopathic juvenile cataracts. the data of patients with idiopathic juvenile cataracts will be reviewed and the data of the patients meeting the inclusion/exclusion criteria will be recorded. once this phase is completed, the prospective phase of the study will start and the patients meeting the criteria will be invited to the site to participate in the study. current data will be collected from the patients who agree to participate in the study and the clinical status of the patients will be evaluated according to the mignarri index. in addition, blood will be obtained from all patients to diagnose ctx disease. blood samples will be sent to duzen laboratories in ankara and analyzed for cholestanol.


Eligibility criteria:
inclusion criteria: * providing the written informed consent form * the patient should be diagnosed with idiopathic bilateral juvenile cataract * idiopathic bilateral juvenile cataract should be diagnosed while the patient must be take a day from one year (age) * syria ciziten who take their citizenship of turkey could be enrolled to the study after signing of informed consent form that translated to mother tongue by sworn translation office approved by ethic committee. exclusion criteria: * if the patient has been diagnosed with ctx before his/her enrollment in the study, * if the patient has been diagnosed with cataract due to any known reasons other than ctx including cataracts related to trauma, * if the patient has been diagnosed with cataract due to cataractogenic treatments, * if the patient has participated in an interventional clinical study within the last 30 days, * if the patient and/or his/her legal representative does not provide consent to participate in the study, * if the patient will not be able to fulfill study requirements according to the investigator's opinion, * if the patient had used cholic acid or chenodeoxycholic acid on or before the date of participation in the study * pregnancy and/or lactation * syria citizen that have not turkey citizenship will not enroll to the study.

Keywords: juvenile cataract ctx diarrhea neonatal jaundice xanthoma
post-op rotator cuff pain study with subacromial bupivacaine infusion

Conditions: Rotator Cuff Tear

Summary: subacromial pain catheters have been used with uncertain efficacy for many years after rotator cuff repair to aid in postoperative pain control. our null hypothesis is that postoperative subacromial continuous infusion bupivacaine catheters will provide no pain control benefits over placebo infusions or no catheter use.

this will be a prospective, randomized, double-blinded placebo controlled study. randomization will be performed by a random numbers table. envelopes will be sealed with the accompanying randomization group.patients will be eligible for inclusion in the study if they have a full-thickness rotator cuff tear that has been deemed reparable by preoperative mri. they will be included in the study if they are medically stable to undergo the surgery and consent to involvement in the study. patients consenting to the study will undergo arthroscopic rotator cuff repair by one of the two senior authors. the surgery will be performed as an outpatient procedure under general anesthesia. the procedure will be performed utilizing the standard techniques of the senior authors. all concomitant pathology found at the time of arthroscopy will be treated in the usual appropriate fashion. at the completion of the rotator cuff repair, patients will be randomly allocated to one of three groups. this will be done by opening a sealed envelope with the randomization allocation. the patients will either be placed into the study group, the placebo group or the control group.

Eligibility criteria:
inclusion criteria: * full thickness rotator cuff tear * pre operative mri * patients who are medically stable to undergo the surgery * patients who consent to involvement in the study exclusion criteria: * prior surgery on the involved shoulder * preoperative mri suggesting that the rotator cuff tear is unrepairable * patients with known allergies to oxycodone, bupivacaine or a similar drug * workman's compensation patients * patients who do not fill out their visual analog scores or their medication diaries.
anesthesia techniques in symptomatic mandibular molars with irreversible pulpitis

Conditions: Anesthesia, Dental

Summary: the aim of this clinical study is to evaluate the success of buccal infiltration (bi) anesthesia + intraligamentary (ili) anesthesia between inferior alveolar nerve block (ianb) anesthesia + buccal infiltration anesthesia in mandibular molar teeth with acute symptomatic irreversible pulpitis.the main questions it aims to answer are: * does the anesthesia techniques adequate to perform root canal treatment painlessly? * which technique achieved pulpal anesthesia? participants were allocated in two groups according to the randomization blocks, with a total of 25 patients in each group. in ianb + bi anesthesia techniques, a total of approximately 2.8 ml of anesthetic solution, 1.8 ml + 1 ml, was applied, while for bi + ili, a total of approximately 1.72 ml, 1 ml + 0.72 ml, was administered. then, root canal treatment was performed. researchers were compared the success of anesthesia techniques in different stages of root canal treatment.

a total of 50 patients, aged between 18-65, who were diagnosed with symptomatic irreversible pulpitis of the mandibular molar tooth, were included in this study. the patients were allocated in two groups according to the randomization blocks, with a total of 25 patients in each group. in ianb + bi anesthesia techniques, a total of approximately 2.8 ml of anesthetic solution, 1.8 ml + 1 ml, was applied, while for bi + ili, a total of approximately 1.72 ml, 1 ml + 0.72 ml, was administered. after the anesthesia, a rubber dam was placed on the associated tooth of the patient for root canal treatment, the endodontic access cavity was opened, and canal preparation procedures were started. the pain levels felt by the patients during the endodontic treatment stages (starting the treatment, opening the endodontic access cavity and pulp extirpation) were determined by heft-parker vas (hp-vas) scale. anesthesia was considered successful in patients who felt no pain (hp-vas ratio = 0) or mild pain (hp-vas ratio ≤ 54) during the procedures.

Eligibility criteria:
inclusion criteria: 1. systemically healthy patients 2. the absence of periapical pathology 3. not sensitive to articaine or epinephrine 4. no facial paresthesia 5. not taking any analgesic drug 6 hours before treatment 6. not taking any medication that interferes with anesthesia, such as tricyclic antidepressants and beta-blockers 7. the absence of pathosis in areas planned for injection 8. not pregnant 9. the absence of pathologic periodontal pockets during probing 10. patients with a mandibular first molar tooth exhibiting symptomatic irreversible pulpitis exclusion criteria: -

Keywords: pain irreversible pulpitis intraligamentary injection inferior alveolar nerve block
study of narrow band imaging in the characterization of residual neoplasia after endoscopic piecemeal mucosal resection

Conditions: Colorectal Neoplasms

Summary: this study is designed to evaluate the diagnostic accuracy of narrow band imaging (nbi) compared with high definition white light colonoscopy (wle) for detection of residual neoplasia in subjects with piecemeal polypectomy scars.

resection of large sessile polyps in the colon (usually more than 2 cm) or those nonpolypoid neoplastic lesions (also called laterally spreading tumors or lst), confers technical difficulty and often are forced to remove into fragmented resection or endoscopic piecemeal mucosal resection. this has been associated with a recurrence of 25%. for this reason, clinical guidelines recommend endoscopic follow-up at 2 to 6 months after piecemeal resection of colorectal polyps to check for residual neoplasia. narrow-band imaging (nbi, olympus) improves visibility and identification of the surface and vascular structures of colon polyps. in contrast to conventional chromoendoscopy, it is easily activated by pressing a button on the endoscope. virtual or conventional chromoendoscopy are applied during resection of polyps defining the border of the lesion. however, there are few studies using narrow band imaging and do not allow to know whether the use of this technique could improve the detection of residual tumor after fragmented polypectomy and avoid complications, time and costs of biopsy and histological analysis. in this context, the european society of gastrointestinal endoscopy (esge) has recently published the first guideline of advanced endoscopic imaging for the detection and differentiation of colorectal neoplasia and recommends conventional or virtual chromoendoscopy in patients with piecemeal polypectomy scar (strong recommendation, low quality evidence). the investigators will perform a randomised, controlled trial of tandem colonoscopy using nbi and wle. the main goal is to compare the rate of detected neoplasia between both techniques and evaluate the diagnostic accuracy of nbi and wle to histology as the gold standard.

Eligibility criteria:
inclusion criteria: * patients over 18 years old who underwent a colonoscopy for any reason in the last 12 month * patients with a basal colonoscopy findings: ≥1 polyp removed in a piecemeal fashion regardless of the size exclusion criteria: * diagnosis of a crc in the basal colonoscopy * subjects who neglect to follow-up * subjects who do not accept informed consent * subjects with high risk of perforation or complications due to sedation, including patients with comorbidities (asa iv-v) * inadequate bowel preparation for colonoscopy (defined by boston bowel preparation score (bbps): ≤ 5 total points; or 0-1 points in any of the 3 segments of the colon)

Keywords: endoscopic mucosal resection piecemeal polypectomy scar colorectal neoplasms narrow band imaging chromoendoscopy
computerized cognitive-behavioral therapy for auditory hallucinations

Conditions: Schizophrenia, Schizoaffective Disorder

Summary: this is a randomized controlled trial, examining the effects of a computerized, internet-based cognitive behavioral therapy (cbt) intervention for persons with a schizophrenia spectrum disorder who experience distressing auditory hallucinations (voices). participants are randomized to one of two conditions: either to receive the 10-session computer-based program on a weekly basis, or to their usual care at their mental health clinic. this study takes place at cambridge health alliance in cambridge massachusetts. it is hypothesized that the participants who participate in the cbt program will have significant improvements in the severity of their auditory hallucinations, as well as their associated distress, compared to the participants receiving usual care.


Eligibility criteria:
inclusion criteria: * participants will be on a stable dose of antipsychotic medication for the past 3 months. * schizophrenia-spectrum diagnosis, including schizophrenia, schizoaffective disorder, schizophreniform disorder, and psychosis, not otherwise specified. * at least moderate severity on brief psychiatric rating scale (bprs) hallucinations item. * naïve to cbtp for auditory hallucinations within the past 3 years. * no current suicidal ideation or hospitalization within the past month. * reading level of at least 4th grade, as measured by the reading section of the wide range achievement test (wrat) * current patient receiving care at cambridge health alliance exclusion criteria: * terminal physical illness expected to result in the death of the study participant within one year. * primary diagnosis of dementia or a diagnosis of a psychiatric disorder secondary to a medical condition. * comorbid dementia (severe cognitive impairment) as indicated by a mini-mental state examination score \<24. * current active substance abuse or dependence with the need for specialized substance abuse services * does not speak english * does not achieve a 4th grade reading level as demonstrated on the wide range achievement test (wrat) * has a legal guardian
continuous glucose monitoring of late preterm birth after corticosteroids

Conditions: Pregnancy Preterm; Neonatal Hypoglycemia; Prematurity

Summary: women undergoing late preterm birth are at high risk of delivering a newborn with neonatal hypoglycemia. the investigators plan to monitor interstitial glucose levels prior to delivery in these women in order to develop a better understanding of the relationship between maternal hyperglycemia and neonatal hypoglycemia.


Eligibility criteria:
inclusion criteria: * pregnancy admitted to labor and delivery between 34w0d and 36w5d * english speaking women * high probability of delivery in late preterm period defined by any of the following: 1. membrane rupture by 2 criteria (pooling, positive nitrazine, or ferning) or leaking amniotic fluid from the cervix 2. preterm labor with intact membrane, defined as at least 6 uterine contractions in 60 minutes and at least: cervical dilation greater than or equal to 3cm dilated or 80% effaced or planned delivery by induction of labor or cesarean in no less than 24 hrs and no more than 7 days, for any indication as deemed necessary by the provider * received at least one dose of corticosteroid within twelve hours of enrollment exclusion criteria: * any prior antenatal corticosteroid course in current pregnancy * systemic corticosteroid administration during current pregnancy * fetal demise or known major fetal anomaly, including cardiac anomaly or hydrops * maternal contraindication to betamethasone: hypersensitivity reaction to any component of the medication, idiopathic thrombocytopenic, purpura, systemic fungal infection, or current use of amphotericin b * diabetes, pregestational or gestational * preexisting plan for intrapartum monitoring of maternal glucose levels for any reason * delivery expected within 12 hours of randomization, because of insufficient time for corticosteroids to confer benefit, including: 1. ruptured membranes with cervical dilation ≥ 3cm or with more than 6 contractions per hour unless pitocin is deferred for at least 12 hours 2. chorioamnionitis 3. cervical dilation ≥ 8cm 4. evidence of non-reassuring fetal status requiring immediate delivery * to ensure that there is an adequate proportion of women presenting at 34 to 35 weeks gestation, enrollment will be restricted so that no more than 50% of the women in the trial present at 36 weeks.

Keywords: steroid corticosteroid betamethasone preterm birth
sequential chemo-radioimmunotherapy followed by autologous transplantation for patients with untreated advanced stage mantle cell lymphoma

Conditions: Mantle Cell Lymphoma

Summary: mantle cell lymphoma (mcl) is a rare and aggressive type of lymphoma, with only about 3,000 cases diagnosed per year. mcl is considered a difficult cancer to treat. this study is being done to better understand how to treat mcl.


Eligibility criteria:
inclusion criteria: * previously untreated advanced stage mantle cell lymphoma (clinical stage 2 with abdominal involvement, stage 3 and stage 4). * histologic diagnosis confirmed by mskcc pathologist as mantle cell lymphoma with cyclin d1, or d2 and/or, d3 staining performed. presence of measurable disease as determined by fdg-pet, ct, endoscopy, colonoscopy, or bone marrow biopsy. * ages 18-70. * transplant eligibility as confirmed by the disease management team. * kps ≥ 70%. adequate organ function: * wbc anc ≥ 1000 cells/mcl and platelet count ≥ 100,000 cells/mcl unless felt to be secondary to underlying mantle cell lymphoma at which any count is permissible. * adequate renal function as determined by cr \< or = to 1.5 mg/dl or 24 hr creatinine clearance ≥ 50 ml/hr * adequate hepatic function as determined by total bilirubin \< or = to 1.5x uln (unless known gilbert syndrome) and ast \< or = to 5.0x uln. * cardiac ejection fraction greater than or equal to 50% as determined by echocardiogram or muga. * for patients ≥ age 60, a stress echocardiogram will be required, with same requirements as above. * dlco greater than or equal to 50% as determined by pulmonary function tests performed prior to initiation of treatment. * patients with positive hepatitis b serologies will be treated per institutional guidelines. exclusion criteria: * prior treatment for mantle cell lymphoma, including more than 7 days of steroids, immunotherapy, radioimmunotherapy, or chemotherapy. this does not include patients who have initiated r-chop at an outside institution within 2 weeks of enrollment. * patients using \> or = to 10mg/day of steroids for any chronic medical condition * pregnant or breast-feeding. note: pre-menopausal patients must have a negative, serum hcg within 14 days of enrollment,. * hiv positive or hepatitis c antibody positive.

Keywords: cyclophosphamide (cytoxan) cytarabine (ara-c) doxorubicin/adriamycin prednisone rituximab tositumomab (bexxar) iodine vincristin lymphoma chemo-radioimmunotherapy autologous transplantation untreated 11-095
effect of education based on the health belief model on healthy lifestyle behaviors in individuals with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this research will be carried out with a randomized controlled experimental design to examine the effect of education based on the health belief model for individuals with type 2 diabetes on their health beliefs, self-efficacy and healthy lifestyle behaviors. during the research, the relevant polyclinic will be visited regularly. the patients who are followed up in the outpatient clinic for type 2 diabetes will be evaluated in terms of sampling eligibility criteria and their willingness to participate in the research will be questioned. the patients to be included in the study will be randomly assigned to intervention and control groups using the random sampling method. in determining the sample size, two groups, intervention and control, were compared using the "g\*power v3.1.9.4" program. effect size (d) = 0.80, type i margin of error (α) = 0.05, minimum sample volume to provide test power (1-β) = 0.90, total 68 (experimental group 34, control group 34) is sick. however, it is planned to recruit 20% more patients (41 experiment, 41 control) in order to increase the power and reliability of the research, and there may be losses in the research process. in the collection of research data; introductory characteristics information form, diabetes health belief model scale, diabetes self-efficacy scale and healthy lifestyle behaviors scale-ii will be applied.


Eligibility criteria:
inclusion criteria: * having been diagnosed with type 2 diabetes in the last 6 months * being between the ages of 18-65 * hba1c ≥ 6.0% * taking oral antidiabetic medication and/or insulin therapy * understanding and speaking turkish * being literate * living in konya * not having a communication problem * being able to use the whatsapp® application * not having internet access problems * individuals who agree to participate in the research by giving their verbal and written consent will be included. exclusion criteria: * having a vision problem * having mental and communication problems * having a neuropsychiatric disorder * having a history of malignant disease * being pregnant

Keywords: self efficacy healthy lifestyle health belief model
efficacy and safety of jak inhibitors in patients with aa: rwe study

Conditions: Alopecia Areata; Janus Kinase Inhibitors

Summary: the introduction of janus kinase inhibitors (jaki) seems to revolutionize the field of alopecia areata (aa) therapeutics. however, the ideal jaki is not yet settled and the real-world data are still missing. to provide evidence about effectiveness and safety of different jaki including tofacitinib, baricitinib, ritlecitinib，abrocitinib, upadacitinib and ifidancitinib in real-world settings and describe baseline disease characteristics and patients profiles that are considered good candidates for jaki in the daily practice. furthermore, we intended to investigate the efficacy and safety of jak inhibitors in patients with aa, as well as to provide clinical evidence for the clinicians and patients when they formulate individualized treatment plans.


Eligibility criteria:
inclusion criteria: * patients with alopecia areata between 2 to 18 years old * patients diagnosed with alopecia areata according to aa guideline * aa patients treated with jaki including tofacitinib, baricitinib, ritlecitinib，abrocitinib, upadacitinib and ifidancitinib for more than 3 months exclusion criteria: * patients had previously received hair implants * other alopecia * other diseases may induce alopecia including psoriasis, lichen planus, et al. * unable to estimate salt score at baseline or at follow-up * patients are participating in other clinical trials
study of the depth of anesthesia on postoperative clinical outcome in patients with supratentorial tumor

Conditions: Anesthesia, Brain Tumor, Supratentorial,Outcome

Summary: recent studies have shown that deep anesthesia is associated with poor outcome. there is still lack of randomized controlled trials with large sample size on the effect of depth of anesthesia on the postoperative outcomes in patients undergoing brain tumor resection. the investigators are performing a randomized and parallel group trial. the aim of the study is to determine whether there is a causal relationship between the depth of anesthesia and postoperative clinical outcome in patients undergoing supratentorial tumor surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled to receive elective supratentorial tumor resection under general anesthesia from 2017 to 2019 will be recruited in the trial. inclusion criteria include ages between 18 and 80 years old, american society of anesthesiologists (asa) physical status ⅲ-ⅳ, surgery duration expected to be equal or more than three hours, postoperative hospital stay expected to be equal or more than five nights, and monitoring bis throughout anesthesia. exclusion criteria: * patients who undergo emergency or awake craniotomy surgery, or unable to present the written consent will be excluded from the trial. the patients whose incision site conflicts with the placement of bis electrode on the frontal and temporal lobe will also be excluded from the study.
phenotypic and genotypic characteristics of pseudomonas aeruginosa isolates in sohag university hospitals

Conditions: Pseudomonas Aeruginosa Infection

Summary: isolation and identification of pseudomonas aeruginosa using basic microbiological methods, such as gram staining, cultivation on cetrimide agar and biochemical reactions from samples from patients with different types of health care associated infections as urinary tract infections, infected burn, ventilator associated pneumonia, blood stream infections and surgical site infections that will be obtained under complete aseptic precautions.


Eligibility criteria:
inclusion criteria: * samples from patients with different types of health care associated infections as urinary tract infections, infected burn, ventilator associated pneumonia, blood stream infections and surgical site infections will be obtained under complete aseptic precautions. exclusion criteria: * any infection before 48 hours of patient admission at hospital