Kornimate/medical-research-clean huggingface dataset:
a parent administered sensorimotor intervention and developmental outcome of preterm infants

Conditions: Premature Infant; Developmental Delay

Summary: advances in medical technologies over the last three decades have increased survival rates in infants born preterm . preterm infants are at high risk of developing developmental delays. implementation of effective strategies aimed at improving the developmental outcome of preterm born children is critical. the proposed study is designed to evaluate the addition of a parent administered sensorimotor program on the developmental outcome of infants who are born preterm.

children who are born prematurely are at a higher risk of developing developmental delays than children born at term. early experiences in the neonatal intensive care unit (nicu) can influence developmental outcomes. sensorimotor interventions as well as parental engagement have been designed with the aim of improving the development of children born preterm. substantial evidence supports the benefits of each intervention on improving developmental outcomes. however, there remains a significant gap in the literature on the efficacy of a parent administered sensorimotor intervention (pasi) program in the nicu on infant's development. the proposed study is designed to evaluate the potential benefits of such a program on infant's development. a randomized block clinical trial will be performed. a total of 84 preterm infants (\< 34 weeks gestation) will be recruited and randomized. infants in the experimental group will receive the sensorimotor program,consisting of tactile (whole body) and oral input for 15 minutes, one time per day, for 10 days. infants in the control group will receive standard care. the following outcomes will be monitored time to attainment of complete oral feeds (primary outcome), rate of weight gain, length of hospitalization, and developmental outcomes at 36 weeks corrected gestational age and at 4, 8, 12, 18 and 24 months corrected age. results from this study will provide us with further knowledge on the impact of sensorimotor intervention on infants' developmental outcome as well as the effect of active parental involvement on infants' development. provision of a pasi program is a safe and low cost effective intervention that may increase the development and quality of life of preterm born children and their family.

Eligibility criteria:
inclusion criteria: * infants born \< 34 weeks gestation * infants whose parent (s) intend on visiting regularly (\> 5 days) exclusion criteria: * infants born with a metabolic disorder or congenital abnormality * infants whose parents are unable to participate due to cognitive, physical or social issues.

Keywords: prematurity development parental engagement parental satisfaction
methotrexate, vinblastine, doxorubicin and cisplatin (mvac) followed by gemcitabine plus cisplatin (gem+cddp) in locally advanced or metastatic bladder cancer

Conditions: Bladder Cancer

Summary: this phase ii trial will study the effectiveness and toxicity of sequential high dose mvac followed by gemcitabine and cisplatin, as first line treatment in patients with locally advanced or metastatic bladder cancer.

high dose mvac and cisplatin/gemcitabine combination regimens have shown comparable efficacy in the first line treatment of advanced or metastatic bladder cancer, whereas the latter regimen has better tolerability. the efficacy and tolerability of the sequential administration of these two regimens is not known.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed transitional cell carcinoma of the urinary bladder. * metastatic or locally advanced disease. * no prior chemotherapy. * performance status (world health organization) 0-2. * measurable or evaluable disease. * measurable disease is defined as at least 1 unidimensional measurable lesion ≥20 mm by conventional techniques or 1 bidimensionally measurable lesion ≥ 20 x 10 mm. lesions that are smaller or uni- or bidimensionally unmeasurable are considered as evaluable disease. * adequate liver (bilirubin ≤ 1.5 upper normal limit, serum glutamate-pyruvate aminotransferase/serum glutamic pyruvic transaminase ≤ 2 upper normal limit, alp ≤ 2.5 upper normal limit), renal (creatinine ≤ 1.5 upper normal limit) and bone marrow (absolute neutrophil count ≥ 1,500/mm3, platelet count ≥ 100,000/mm3) function. * life expectancy \> 3 months. * patients must be able to understand the nature of this study and give written informed consent. exclusion criteria: * history of serious cardiac disease (unstable angina, severe congestive heart failure, myocardial infarction within the previous 6 months, ventricular arrhythmias). * second primary malignancy, except for non-melanoma skin cancer and in situ cervical cancer. * active infection. * uncontrolled inflammation. * pregnant or lactating women. * psychiatric illness or social situation that would preclude study compliance.

Keywords: bladder cancer
environmental health and myopia prevention and control

Conditions: Refractive Errors; Myopia (Disorder)

Summary: myopia is one of the major causes of low visual acuity during childhood. it is generally more prevalent in urban areas than in rural areas. current evidence does not address our understanding of the myopia incidence and development and associated risk geographic factors, such as green spaces. therefore, our study aimed to evaluate the association between geographic factors and myopia base on a population-based large-scaled cohort design.


Eligibility criteria:
inclusion criteria: * schoolchildren in the 1st to 4th grades exclusion criteria: * schoolchildren unwilling to participate
establish the caring model of children with chronic kidney disease and end-stage renal disease: to set up childhood glomerular filtration rate (gfr) formula in taiwan

Conditions: Chronic Kidney Disease; End-Stage Renal Disease

Summary: inulin's usefulness as a diagnostic agent is based on the method of its elimination from the body. inulin is biologically inert, unbound by plasma proteins, freely filtered at the glomerulus, and is neither reabsorbed, metabolized nor secreted by the kidneys. it is excreted almost entirely by glomerular filtration. inulin clearance is considered to be identical to glomerular filtration rate (gfr).


Eligibility criteria:
1. main inclusion criteria: pediatric opd, age \< 18 y/o. 2. main exclusion criteria: acute renal failure, edema, muscular dystrophy, pleural effusion, ascites, malnutrition, neurogenic bladder, heart failure and ketoacidosis. and taken cimetidine or trimethoprim, and accepted renal replacement therapy.

Keywords: inulin childhood gfr formula
nebulized magnesium sulfate in children with moderate to severe asthma

Conditions: Asthma

Summary: the purpose of this study is to investigate the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency.

the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency follow asthma severity score and length of stay

Eligibility criteria:
inclusion criteria: * pediatric asthma patients with moderate to severe exacerbation exclusion criteria: * known allergy to magnesium sulfate * history of neuromuscular disease, cardiac disease, renal disease, or underlying chronic lung disease * use of oral steroid medication within 72 hours of presentation * radiographic evidence of pneumonia at presentation * administration of intravenous magnesium sulfate prior to study enrollment

Keywords: magnesium nebulization asthma sulfate children pediatric
effect of cervical block on recurrent laryngeal nerve monitoring during thyroid surgery

Conditions: Thyroid Surgery

Summary: non-inferiority study aimed to assess the impact of cervical block on recurrent laryngeal nerve monitoring during thyroid surgery secondary outcomes will assess post-operative recovery, post-operative pain and post-operative dysphonia


Eligibility criteria:
inclusion criteria: * patients over 18, able to give consent after clear and fair information * affiliated to social security * total thyroidectomy performed in the context of graves' disease in biological euthyroidism with the need for surgical treatment (pregnancy project, fluctuating tsh, etc.), or multiheteronodular goiter with suspect or compressive nodules, or lobo-isthmectomy * no previous homolateral cervical surgery * professional activity * telephone line (at home or cellular) exclusion criteria: * patients over 18 under legal protection * allergy to local anesthetics * existence of preoperative laryngeal dysphonia or paralysis * patient with a submerging goiter (lower edge of the thyroid not seen on the preoperative cervical ultrasound) * presence of uncontrolled infectious pathology * pregnant or breastfeeding woman or no contraception * lymph node dissection planned or patient at high risk of lymph node dissection (bethesda 5 and 6)

Keywords: thyroid surgery cervical nerve block recurrent laryngeal nerve monitoring enhanced recovery after surgery
muscle mechanical response in exercise.

Conditions: Muscle Weakness

Summary: the muscular response on the main muscles of the propulsive phase of the upper limb in crawl has been evaluated by tensiomyography (tmg), which was carried out through three parameters: activation time (td), contraction time (tc) and maximum deformation (dm). the objective of this study is to evaluate the hypothesis of changes produced between lactic resistance training with passive rest and lactic resistance training with active rest. for this, thirty swimmers participated, with an average age of 20 years.


Eligibility criteria:
inclusion criteria: * be between 18 and 25 years old. * have a minimum mark or have participated by ranking in a crawl event in the territorial championship of madrid in the current season belong. * to the male gender. exclusion criteria: * subjects who did not meet the minimum age and did not obtain the minimum mark and did not sign the informed consent.

Keywords: tensiomyography triceps dorsal exercise pectoral
vafseo outcomes in-center experience

Conditions: Anemia of Chronic Kidney Disease

Summary: this trial is an investigator-initiated, multi-center, randomized (1:1), open-label, active-controlled, pragmatic study of the safety of vadadustat administered three times per week for the treatment of anemia in in-center hemodialysis patients with end stage kidney disease (eskd). this study will obtain long-term safety data in a large sample of subjects receiving in-center hemodialysis to support adoption of three times per week vadadustat dosing.


Eligibility criteria:
inclusion criteria: * adult patients greater than or equal to 18 years of age. * receiving outpatient in-center hemodialysis at least three times per week for end-stage kidney disease. * currently prescribed or eligible for erythropoiesis-stimulating agent based on approved facility policy * understands the procedures and requirements of the study and provides written informed consent and authorization for protected health information disclosure. exclusion criteria: * contraindication to receive vadadustat or any of its known constituents per uspi. * cirrhosis or active, acute liver disease. concomitant use of any hypoxia-inducible factor prolyl-hydroxylases or oat1/oat3 inhibitors (probenacid, rifampicin, gemfibrozil, or teriflunomide). * unable to comply with study requirements or in the opinion of a healthcare provider or a member of the central study team, not clinically stable to participate in the study. * pregnant at time of consent (per subject self-report).
the arteriovenous vascular (av) access trial

Conditions: End-Stage Kidney Disease; Hemodialysis Complication

Summary: this study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions

this study will determine the effects of arteriovenous (av) fistula versus av graft vascular access strategy on the rate of catheter-free dialysis days and access-related infections - costs associated with the dialysis vascular access - patient-reported satisfaction with different processes of vascular access care (catheter, fistula, or graft) - and the relationship between preoperative functional status and incidence of fistula or graft maturation failure

Eligibility criteria:
inclusion criteria: * age 60 years or older * end-stage kidney disease on hemodialysis via a central venous catheter * hemodialysis is the long-term modality of treatment for end-stage kidney disease * central venous catheter is the sole vascular access used for hemodialysis at the time of referral for arteriovenous access creation * referred by patient's nephrologist for placement of arteriovenous access * at least one of the following comorbid conditions: cardiovascular disease, peripheral vascular disease, and/or diabetes mellitus * medically and surgically eligible to undergo surgical placement of an arteriovenous access, deemed by the treating healthcare providers * native vasculature deemed preoperatively to be suitable for surgical creation of either type of arteriovenous access (arteriovenous fistula or arteriovenous graft) in the opinion of the surgeon * patient agreed to study participation and signed the informed consent exclusion criteria: * severe cardiac disease defined as presence of either of the following three conditions: congestive heart failure with ejection fraction ≤ 20%, heart transplant, or ventricular assist device * known or suspected central vein stenosis or vascular obstruction on the side of planned study access creation, unless corrected prior to randomization * planned arteriovenous fistula creation by means other than suture or vascular anastomotic clips (e.g. endovascular surgery or other anastomotic creation devices) * anticipated kidney transplant within 12 months * anticipated conversion to peritoneal dialysis within 12 months * anticipated transfer of nephrology care to a clinic outside the study participating centers within 12 months * anticipated non-compliance with medical care based on physician judgment * a condition in which, in the opinion of the site pi renders the patient not a good candidate for study participation.

Keywords: hemodialysis end-stage kidney disease central venous catheters arteriovenous fistula [avf] arteriovenous graft [avg] arteriovenous vascular access
non-interventional open label study to investigate the effect of quetiapine xr on patient satisfaction and quality of life in patients with schizophrenia

Conditions: Quality of Life in Schizophrenia

Summary: since subjective well-being and quality of life (qol) are increasingly being recognized as important treatment outcomes in patients with schizophrenia (hofer et al., 2004; becker et al., 2005), the aim of this study is to investigate the effect of treatment with quetiapine xr on these parameters in the acute hospital and the subsequent ambulant care setting. the study is planned to be conducted in 15 centers all over austria and, overall, about 150 inpatients with a icd-10 diagnosis of acute schizophrenia are planning to be enrolled. the duration of the whole trial will be approximately 4 months, whereas 2 visits during hospitalization and two further visits after discharge will be scheduled. at each visit, adverse events and safety parameters, patient satisfaction and effectiveness of the current treatment, as well as concomitant medication and dosing schedules will be assessed and documented.in addition to that, the patients' overall satisfaction with antipsychotic therapy and their current quality of life will be determined using a qol questionnaire, focussing on the subjective experience with quetiapine xr.


Eligibility criteria:
inclusion criteria: * adult schizophrenia patients * inclusion according to summary of product characteristics exclusion criteria: * diagnosis other than schizophrenia * patients for which seroquel xr is not registered (pregnant women, children and adolescents...)

Keywords: quality of life patient satisfaction schizophrenia investigate quality of life in schizophrenia
shoulder rotational flexibility and throwing arm injuries of baseball pitchers

Conditions: Shoulder Injuries; Shoulder Flexibility; Rotational Resistance of Shoulder

Summary: the evaluation of any relationship between the rotational resistance of the shoulder and shoulder flexibility with throwing arm injuries in professional and college level pitchers.


Eligibility criteria:
inclusion criteria: * currently competing * healthy pitching arm exclusion criteria: * inactive status * previous injury

Keywords: shoulder injuries flexiblity rotational resistance
temperature dependent changes in i-gel masks

Conditions: Airway Management

Summary: the i-gel® mask is a second generation, single use supraglottic airway device which does not have an inflatable cuff. the cuff consists of a thermoplastic elastomer and its mechanism of sealing still remains unclear. various theories such as temperature-dependent changes in hardness and volume expansion as well as fluid absorption have been discussed.

the i-gel® mask (intersurgical, workingham, uk), is a second generation, single use supraglottic airway device. in contrast to other devices its' cuff consists of a thermoplastic elastomer (styrene-ethylene-butadine-styrene) instead of an inflatable cuff. previous studies have shown, that over time the sealing improved compared to the moment of insertion. the sealing process may be based on various mechanisms. it is assumed, that the warming from room to body temperature leads to an improved adaptation to the patient-specific anatomy due to a softening of the elastomer. by definition, an elastomer is softened by the effect of temperature and become harder when reaching the glass transition temperature. in this context, dingley et al. described a change in the degree of hardness as a function of temperature. prewarmed i-gel® masks (42°c, 30min.) seem to have smaller leak volumes compared to masks stored at room temperature postinsertion in paralyzed patients, but was not reproducible in non-paralyzed patients. looking at the sealing pressure chauhan et al. reported that i-gel® masks required a lower pressure compared to masks with an inflatable cuff. at this point it is not yet clear, whether the thermoplastic cuff material only expands due to an increase in temperature. liquid absorption and a consecutive expansion is also theoretically conceivable. therefore, the aim of the present study is to examine the i-gel® mask within the scope of a benchtop study for temperature-dependent volume expansion and liquid absorption.

Eligibility criteria:
inclusion criteria: * elective surgery exclusion criteria: * contraindications for the use of i-gel masks. * emergency operation * non fasted patient

Keywords: laryngel mask
safety and dose ranging study of insulin receptor mab-idua fusion protein in patients with mps i

Conditions: Mucopolysaccharidosis I

Summary: agt-181 is a fusion protein containing alpha-l-iduronidase that is intended to deliver the enzyme peripherally and to the brain, when administered intravenously. this study is a safety and dose ranging study to obtain safety and exposure data, as well as information on the biological activity of the investigational drug.


Eligibility criteria:
inclusion criteria: * male age 18 years or older * diagnosis of mps i (documented fibroblast or leukocyte idua enzyme activity level of less than 10% of the lower limit of the normal range of the measuring laboratory) * voluntary written consent by patient or legally responsible representative * all women of childbearing potential and sexually mature males must be advised to use a medically accepted method of contraception throughout the study. * negative pregnancy test (females) * must not have received ert for at least 6 weeks prior to agt-181 treatment * must have elevated urinary gags if no ert has been received in the prior 3 months exclusion criteria: * refusal to complete baseline evaluations. * any medical condition or other circumstances that may significantly interfere with study compliance * receipt of an investigational drug within the prior 90 days * history of diabetes mellitus or hypoglycemia * clinically significant spinal cord compression, evidence of cervical instability. * known hypersensitivity to alpha-l-iduronidase or any of the components of agt-181. * known to be nonresponsive to standard ert treatment. * previously successful (engrafted) hematopoietic stem cell transplantation that resulted in normalization of urinary gags. * contraindication for lumbar puncture

Keywords: mps i
a study of patients undergoing surgical treatment for oesophageal atresia

Conditions: Atresia Esophagus

Summary: oesophageal atresia (ea) is a rare congenital anomaly whose prevalence varies between 1 and 2 per 5000 live births in europe. this condition is characterised by an interruption of the oesophagus often associated with the presence of a tracheo-oesophageal fistula (fte). although considerable progress has been made in the treatment of ae in recent years, the aetiology of this defect is still not fully understood and several theories have been put forward to explain this phenomenon. what they have in common is an abnormal separation of the primary oesophagus and trachea. the main goal of ae treatment is the closure of the fte using surgical techniques. this is a non-profit, multicentre longitudinal observational cohort study. this study will enrol patients who underwent surgery for oesophageal atresia during the period 2011-2021 and are still in follow-up at participating clinical centres. the primary objective is to assess the incidence of musculoskeletal abnormalities, of any type, in the long term (4 years after surgery) in patients with oesophageal atresia treated surgically by two different approaches: postero-lateral thoracotomy and mini-thoracotomy with muscle preservation


Eligibility criteria:
inclusion criteria: * patients with oesophageal atresia (type iii according to ladd's classification); * patients who underwent their first operation for oesophageal atresia in the period 2011-2021 * signature of written informed consent and consent to the study and privacy. exclusion criteria: * not signature of written informed consent and consent to the study and privacy.
comparison of three different strategies to prevent propofol induced pain during infusion

Conditions: Induction of Total Intravenous General Anesthesia

Summary: propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. three different strategies to prevent propofol induced pain will be studied compared with placebo. pain will be scored with a four-point scale.


Eligibility criteria:
inclusion criteria: healthy adults (asa 1-2) for scheduled surgery under general anesthesia with propofol exclusion criteria: * pregnant * sedative or analgesic drug 24h before surgery * allergy with drug used in the study * difficulty of communication * absence of informed written consent

Keywords: propofol pain general anesthesia prevention