Kornimate/medical-research-clean huggingface dataset:
molecular genetic epidemiology of three cardiac defects -scor in pediatric cardiovascular disease

Conditions: Cardiovascular Diseases; Heart Diseases; Defect, Congenital Heart; Heart Septal Defects, Ventricular; Heart Septal Defects, Atrial; Endocardial Cushion Defects

Summary: to identify genes involved in the pathogenesis of three types of congenital heart disease, atrial septal defects, paramembranous ventricular septal defects, and atrioventricular canal defects.

background: congenital heart defects (chds) are thought to result from genetic and environmental factors that disturb cardiac embryogenesis. because families with multiple members affected with atrial septal defects (asds) and atrioventricular canal defects (avcds) have been described in previous studies, and the paramembranous ventricular septum is in part completed by the formation of the atrioventricular cushions, this project describes a genetic-epidemiologic study of asds, paramembranous ventricular septal defects (vsds), and avcds design narrative: the study is one of several subprojects within a specialized center of research (scor) in pediatric cardiovascular disease. three groups of subjects, each with surgically- or echocardiographically-confirmed diagnoses of asds, vsds or avcds have been identified for study at the university of iowa hospitals and clinics, and at wolfson children's hospital in jacksonville, florida. a fourth group of older subjects with asds and their progeny will be studied at iowa because of the reported high recurrence of heart disease in the offspring of subjects with asds. the strategy calls upon the molecular genetic capacities available at the university of iowa to carry out genome-wide searches for genetic loci involved in these defects. several candidate regions have been identified for asds, vsds and avcds. in addition, three well-recognized syndromes provide additional candidate regions - down syndrome, holt-oram syndrome and 8p-syndrome. parent-affected child trios will be genotyped for closely-spaced markers within these regions and linkage disequilibrium analysis will be used to narrow or exclude these candidate intervals. a genome-wide association study of the trios will employ a parsimonious technique in which dna from cases with the same chd phenotype will be pooled, and compared to the pooled dna from their parents. loci will be identified where the allele frequency distributions in the affected children and their parents are significantly different. when such loci are identified, a finer localization of the chromosomal area will be undertaken using a high-density set of short tandem repeat polymorphic markers that spans each of the candidate intervals. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
calming alternatives learned during mri-guided breast biopsy

Conditions: Breast Cancer; Breast Pain; Pain, Acute; Anxiety; Coping Skills; Self Efficacy

Summary: the proposed randomized study evaluates whether a controlled breathing intervention could be efficacious for reducing pain in the mri-guided breast biopsy setting. support for this intervention stems from experimental and clinical studies on the effects of controlled breathing on pain. implementing a controlled breathing intervention during mri-guided breast biopsy has the potential to provide effective pain management in this outpatient setting. the primary study objectives are to assess the feasibility, acceptability, and efficacy of a novel audio-recorded controlled breathing intervention for reducing breast and body pain in women undergoing mri-guided breast biopsy. the secondary study objectives are to evaluate the effects of controlled breathing on measures of physiological reactivity (i.e., blood pressure and heart rate), pain catastrophizing, and self-efficacy for pain and anxiety.


Eligibility criteria:
inclusion criteria: * women undergoing mri-guided core needle breast biopsy at the duke cancer institute * ability to speak and read in english * age ≥ 18 years * ability to provide meaningful consent exclusion criteria: * hearing impairment that is documented in the medical record that would limit the use of the guided intervention or music * cognitive impairment that is documented in the medical record or results in being unable to provide meaningful consent * undergoing iv-administered sedation

Keywords: controlled breathing mri-guided breast biopsy breast pain body pain anticipatory pain anxiety coping skills self efficacy
use of airtime structure to improve interactive voice response surveys in bangladesh and uganda

Conditions: Surveys and Questionnaires; Noncommunicable Diseases

Summary: this study evaluates the effect of three different airtime incentive structures on interactive voice response (ivr) survey cooperation, response, refusal and contact rates, as compared to a control group, in bangladesh and uganda.

using random digit dialing (rdd) sampling technologies, participants were randomized to one of three airtime incentive structures contingent on them completing the noncommunicable disease risk factor survey. this mobile phone survey was sent as an interactive voice response (ivr). in ivr surveys, participants use their touch tone key pad to answer pre-recorded questions. (i.e. if you are male, press 1; if you are female, press 2). this study is being conducted in both bangladesh and uganda.

Eligibility criteria:
inclusion criteria: * access to a mobile phone * greater or equal to 18 years of age * in bangladesh, conversant in either english or bangla language. in uganda, conversant in either luo, runyakitara, luganda or english languages. exclusion criteria: * less than 18 years of age

Keywords: mobile phone surveys interactive voice response incentive
comparison of humidification devices during non invasive ventilation, in acute respiratory failure

Conditions: Respiratory Failure; COPD; Hypoxemia; Non Invasive Ventilation

Summary: comparison of humidification devices during non invasive ventilation, in acute respiratory failure. the hypothesis was, due to dead space, lower humidification, a reduced efficiency of the technique (niv) when hme are used in comparison with hh.

comparison of humidification devices during non invasive ventilation, in acute respiratory failure. the hypothesis was, due to dead space, lower humidification, a reduced efficiency of the technique (niv) when hme are used in comlparison with hh several physiological previously performed showed that 1) with hme, because of its working principles, humidification was reduced because of leaks 2) work of breathing was increased with hme because of dead space and 3) alveolar ventilation was reduced with hme because of additional technical dead space. for these reasons, the hypothesis was an improvement of niv tolerance, of efficiency to clear te co2 with hh in comparison with hme and finally to reduce the intubation rate with hh. the patients were included when requiring niv (see inclusion and exclusion criteria) and randomisation was performed with stratification according to presence or absence of respiratory acidosis. the number of patients to include was baszd on the hypothesis that intubation rate would be reduced from 40 with hme to 25% with hme. a total of 250 patients was required with alpha risk of 0,05 and beta risk of 0,2 (power 80%). intubation criteria were predefined according to the litterature. the expected duration was 18 months. the official support was institutional (drrc of ap-hp). hh were furnished free of charge, as well as hme. masks used were the same in both groups.

Eligibility criteria:
inclusion criteria: * age between 18 and 85 years * exacerbation of dyspnea lasting less than two weeks two or three following criteria : * respiratory rate higher or equal to 25 b/min * sao2 lower or equal to 90% (breathing room air or oxygen) * arterial ph \< 7.35 exclusion criteria: * immediate need for intubation * cardiac arrest or rr\< 10 breaths/min. * systemic hypotension (sap \< 80 mmhg ) with no response to 500 ml of macromolecules * coma defined by gcs \< 8. * high probability of surgical procedure * major facial deformity * pneumothorax * bad short-term prognosis * refusal of intubation by the patient or do not intubated order.

Keywords: acute respiratory distress with hypercapnia with hypoxemia requiring niv
arthroscopic wafer and ulnar shortening in ulnar abutment

Conditions: Wrist Impaction

Summary: there are many management options of ulnocarpal abutment depends on clinical evaluation and imaging of this joint. arthroscopic treatment is the simplest solution for these conditions.


Eligibility criteria:
inclusion criteria: * obvious ulnar abutment syndrome with ulnar side wrist pain exclusion criteria: * ulnar minus or neutral variance * central and radial wrist pain * osteoarthritis of the wrist.
comparison of effects of activity base therapy vs strength training on gait performance in chronic stroke

Conditions: Stroke

Summary: stroke is a leading cause of disability worldwide affecting both male and female especially in older people. functional independence and locomotion are hampered in stroke, therefore, affecting their quality of life. objective: to find the comparative effects of activity base therapy vs strength training on gait performance in chronic stroke patients.

it was a randomized controlled trial, conducted in physical therapy department of sir ganga ram hospital. 20 chronic stroke patients were equally divided into two groups. in group-a patients were treated with activity base therapy and in group-b patients were treated with strength training. patients were treated for a total of 6 weeks (12 sessions), 1 hour in a day, 3 times per week. patients were assessed using timed up and go (tug) test and fugl meyer examination-lower extremity (fme-le). spss 25 was used toanalyze the dat

Eligibility criteria:
inclusion criteria: * participants were at least 6 months post stroke. * ability to walk independent or with help of walking aids * ischemic stroke patients included in study. * mini mental state examination patients fully understand the commands exclusion criteria: * presence of orthopaedic problems. * neurological disorders. * psychological problems. * cognitive issues. * people with severe visual issues. * participants with other medical complications foot ulcers, orthopaedic or other neurological impedance

Keywords: activity based therapy chronic stroke gait strength training exercises
feasibility study to evaluate the safety of topically applied revera in subjects with venous leg ulcers

Conditions: Venous Stasis Ulcers

Summary: the purpose of this study is to perform a preliminary evaluation of the safety of revera wound care when topically applied to venous leg ulcers for 8 weeks of treatment.

the purpose of this study is to perform a preliminary evaluation of the safety of revera wound care when topically applied to venous leg ulcers for 8 weeks of treatment. this evaluation will be done through tabulations of adverse events (ae), review of complete blood counts (cbc) with differential and platelet, and measuring wound healing rate. the secondary purpose of the study is a preliminary evaluation of an increase in the healing rate of venous leg ulcers treated with revera wound care. this evaluation will be done through measuring wound healing rate (which is also being used to evaluate safety) and complete wound healing.

Eligibility criteria:
inclusion criteria: * 18 years of age or older. * diagnosis of non-healing venous leg ulcer by the following criteria: * dependent peripheral edema, dermatitis, hyperpigmentation. * an ankle to arm arterial pressure ratio \> 0.7 as measured by arterial doppler. * venous stasis ulcer is ≥ 2 cm² in size. * if female subject of reproductive age, have had a negative pregnancy test within one week of study entry and are using adequate birth control. exclusion criteria: * subject known to be allergic to aquacel dressing or components. * peripheral arterial insufficiency (as determined by doppler abi), uncontrolled congestive heart failure (chf), vasculitis, uncontrolled diabetes mellitus. * severe contact dermatitis (allowable if it does not interfere with application of the dressings). * concomitantly receiving systemic corticosteroids in doses exceeding 20 mg per day. * involvement in another experimental drug trial within the last month. * clinical evidence of cellulitis or infection in or around the ulcer. * history of non-compliance to medical regimens and is not considered reliable. * unable to understand the study evaluations and provide a written informed consent.
cyp2d6 genotype-guided management of opioid analgesics in patients undergoing elective ventral hernia repairs

Conditions: Ventral Hernia

Summary: pilot pragmatic trial using an implementation science approach to determine the feasibility of a cyp2d6-guided opioid prescribing for patients undergoing elective vhrs compared to usual care. assess the efficacy (promis pain intensity and hernia-related qol) of a cyp2d6-guided opioid prescribing approach for patients undergoing elective vhrs.


Eligibility criteria:
inclusion criteria: * \> 18 years age undergoing a ventral hernia repair (vhr) ≥1.5 cm in diameter with mesh. exclusion criteria: * ventral hernia \<1.5 cm * primary ventral hernia repair (vhr) without a mesh * emergency operative procedure * receiving chronic opioid therapy (defined as use of opioids on most days for \>3 months) * allergy to opioids * women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup
emulsion lipid digestion & satiety study - effect of physical state and acid stability

Conditions: Healthy

Summary: the purpose of this study is to compare the changes in blood lipids and feelings of satiety after consumption of acid stable or acid unstable oil-in-water emulsions in which the droplets are in either the liquid or partially solid (i.e. crystalline) states.

a double blinded randomized cross-over acute meal study will be carried out in which 15 healthy male participants will attend four study visits, separated by at least one week. on each study visit, fasted participants will consume either the emulsion with solid or liquid droplets and that is either acid stable or acid unstable, in a randomized order. all emulsions will have similar compositions, mainly differing in terms of droplet physical state, achieved by using lipids with different melting temperature. the emulsions will also contrast in terms of colloidal stability to acids, achieved by using different emulsifiers. this will isolate the impacts of physical state and acid stability, and their interactions. postprandial lipemia, gastric emptying and satiety will be measured for 6 hours after consumption of each test beverage. the study meals will include crushed acetaminophen, the appearance of which will be measured in plasma as a measure of liquid content gastric emptying. it will also include periodic measurements of the gastric antrum area by ultrasound to assess the rate of gastric emptying. participants will be asked to maintain their usual lifestyle habits throughout the study, with some changes in the 48 hour period leading up to each of the four visits.

Eligibility criteria:
inclusion criteria: * bmi of 18 - 26 kg/m2 * generally healthy * non-smoking * non to moderate alcohol drinkers * fasting plasma cholesterol level \<5.2 mmol/l * plasma triacylglycerol level \<1.7 mmol/l * plasma glucose level \<5.6 mmol/l * no history of gastric surgeries exclusion criteria: * history of major medical conditions * taking prescription medications/ over the counter medications * taking natural health products/ dietary supplements (other than a multivitamin) * oral antibiotic use in the previous 3 months * planning to take oral antibiotics in the next 3 months * food allergy/anaphylactic/life-threatening allergy * smokers/ regular users of recreational drugs * elite/ training athletes * significant weight loss/ gain during the past 3 months * previous reaction/ sensitivity to acetaminophen * inability to avoid taking acetaminophen for 48 hours * sensitivity to the artificial sweetener sugar twin® sucralose and artificial vanilla extract * not willing to consume sugar twin® sucralose or artificial vanilla.
efficacy of two physiotherapy intervention methods applied in subjects in the social-healthcare setting with nonspecific neck pain.

Conditions: Neck Pain

Summary: the overall objective of this study is to compare the effectiveness of two physiotherapy treatments, one based on the application of massage most current analgesic tens compared to a second massage treatment based on more specific stretching techniques in subject in th social-health care setting with non-specific neck pain.

the subjects included in the sample will be evaluated according to the above-mentioned parameters by researchers trained and assigned for this purpose. the data collection of the different variables will be carried out before and after the completion of the programs designed for the study. the programs designed for the experimental groups have a duration of 10 sessions, twice a week.

Eligibility criteria:
inclusion criteria: * age range between 18-60 years. * cervical pain of non-specific origin or cervicalgia type i and ii according to the quebec - task force on spinal disorders. * be willing to participate in the study and sign the informed consent form. * have at least one year of seniority in the company exercising the current professional activity within the team of socio-health personnel. exclusion criteria: * cervicalgia with neurological involvement or caused by pathologies such as: inflammatory disease, neurological disease, rheumatic disease, severe osteoporosis, fracture, dislocation, vertebro-basilar insufficiency, neoplasia or infection. * spine surgery. * present metallic implants at the spinal column level. * have received physiotherapy or alternative treatment in the last 6 months before starting the study. * to present any type of inconvenience to the application of electrotherapy (score ≥45 points in eapp).

Keywords: inespecif pain physicaltherapy
high tone power therapy for hemiparetic cerebral palsy children

Conditions: Hemiparetic Cerebral Palsy Children

Summary: balance reactions and postural control are inadequate in children with cp which affect their daily living activities. so, different treatment modalities have been used to improve balance for cerebral palsy children. recently, high tone power therapy is a new quantum leap in the field of electro therapy that can be used to stimulate nerves and muscles, so this randomized controlled study will be conducted to investigate the effect of high tone power therapy on balance and quality of life in hemiparetic cerebral palsy children.


Eligibility criteria:
inclusion criteria: * age ranged from 6 to 8 years. * height not less than one meter. * their spasticity will range from 1 to 1+ according to the modified ashworth scale. * children have normal flexibility of the lower back muscles as adequate flexibility with normal muscle length is essential for proper joint function and efficient movement. * exclusion criteria: * children will not follow instructions. * children with any cardiopulmonary problems, attitude and psychiatric disorders, length discrepancy; and seizures. * tightness of the hip flexors.
malnutrition in chinese hospitalized patients and optimizing the usage of nutritional screening tools

Conditions: Malnutrition

Summary: the purpose of this study is: * to diagnose malnutrition in chinese hospitalized patients with four nutritional screening tools: mini-nutritional assessment - short form, subjective global assessment, malnutrition universal screening tool and nutritional risk screening 2002. * to optimize the usage of nutritional screening tools based on data-mining methods.


Eligibility criteria:
inclusion criteria: * ages≥18; admitted to hospital≥24h and did not receive operation until 8.am next day. exclusion criteria: * patients who were pregnant or breast-feeding, and those who could not be interviewed or provide informed consent were excluded.
an investigational immuno-therapy study of bms-986205 combined with nivolumab, compared to nivolumab by itself, in patients with advanced melanoma

Conditions: Melanoma; Skin Cancer

Summary: the purpose of this study is to see if bms-986205 combined with nivolumab, compared to nivolumab by itself, is more effective in treating melanoma that has spread or is unable to be removed by surgery, and has not previously been treated


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * 12 years and older unless not permitted by local regulations; in that case 18 years old and older * eastern cooperative oncology group (ecog) performance status of less than or equal to 1 * histologically confirmed stage iii (unresectable) or stage iv melanoma, per the american joint committee on cancer (ajcc) staging manual (8th edition) * treatment-naïve participants (no prior systemic anticancer therapy for unresectable or metastatic melanoma) * measurable disease per recist v1.1 exclusion criteria: * active brain metastases or leptomeningeal metastases * uveal or ocular melanoma * participants with active, known, or suspected autoimmune disease * prior malignancy active within the previous 3 years except for locally curable cancers that have been apparently cured other protocol defined inclusion/exclusion criteria could apply
insoles in prevention of lower limb injuries

Conditions: Lower Limb Overuse Injuries

Summary: to address whether custom made foot insoles could be used for primary prevention of lower limb overuse injuries, the investigators conducted a prospective, randomized controlled study comparing the use of insoles and standard shoes in healthy young adults exposed to increased physical activity.


Eligibility criteria:
inclusion criteria: * healthy conscripts without any diagnosed deformities of lower limb by physician in premilitary physical examination exclusion criteria: * major orthopaedic or medical conditions (e.g., diabetes, inflammatory arthritis, previous severe trauma (exclusion criteria for the military service) * patients were excluded from our study if they already had insoles prescribed by a physician or a physiotherapist (eight patients) * since only 2% of finnish conscripts are females, they were excluded from the study

Keywords: overuse injuries conscript prevention