Kornimate/medical-research-clean huggingface dataset:
methodological study to compare the effect of different methods of measuring cat allergy symptoms in patients that have immunized their cats with fel-cmv.

Conditions: Hypersensitivity

Summary: in this project we will monitor the symptoms of cat allergic participants who live together with a cat which is immunized with fel-cmv using the novel symptom recording method "hyposcore", a general weekly symptom score, and a skin prick test before and after immunization of the cat. this project may enable us to determine if the scoring system and the tests are able to detect a difference in participant symptoms before and after immunization of the cats.


Eligibility criteria:
inclusion criteria: * signed informed consent after participants' information * 18 to 65 years, male or female * participant understands the nature, meaning and scope of the study * positive screening prick test (wheal diameter ≥ 3mm) to histamine dihydrochloride 10mg/ml * positive screening prick test (mean wheal diameter ≥ 3 mm) when tested with already standardized cat allergen extract * positive screening scratch test when tested with cat dander sample of participant's cat. * living with a cat in the same household and parallel participation in the cat study in which the cat will be immunized * a positive clinical history with inhalant allergy presumably due to cat allergen exclusion criteria: * immunosuppression or haematological diseases, in particular anaemias or leukaemia * other previous or current condition or participation in clinical trials influencing the results of the present study by discretion of the investigator * incapable of understanding the nature, meaning or scope of the research project or incapable of giving written informed consent * unwilling or incapable of following the study procedures, e.g. due to language problems, psychological disorders, dementia, known or suspected drug or alcohol abuse etc. * women who are pregnant or breast feeding or having the intention to become pregnant during the course of the study * positive skin reaction in the screening prick test to negative control * history of anaphylactic reaction to pet allergens * severe diseases influencing the results of the present study by discretion of the investigator * immunotherapy with fel d 1 / cat allergen preparation during the past two years. * skin lesions and excessive hair growth in the skin test areas * treatment with prohibited concomitant medications with the exception of medications with local effects which will not influence the results of the skin tests and the results of the other tests (testing period) * the participant should not suffer from other respiratory allergies during this study (people who suffer from asthma are not excluded)
the subvastus approach in total knee arthroplasty

Conditions: Osteoarthritis

Summary: the purpose of this study is to determine if the observed benefits of minimally invasive total knee arthroplasty, namely decreased hospital stay and increased range of motion, can be achieved with standard knee arthroplasty using the subvastus approach.


Eligibility criteria:
inclusion criteria: * you are willing to take part in the study, including signing this form after carefully reading it. * you are available for follow-up for a minimum of 24 months (2 years). * you have no medical conditions that prevent you from having surgery. * this is the primary (first) knee replacement for this knee * you are fluent in english and are able to understand your responsibilities in this study. exclusion criteria: * active, local or systemic infection * fibromyalgia or other chronic pain syndrome * inability to follow the study requirements * had this knee replaced before * had a previous surgery on this knee that would interfere with the mis approach (examples are femoral-femoral bypass, femoral-popliteal bypass, and quadricepsplasty) * body mass index (bmi) \> 35, as you would not be eligible for the mis approach.
improving work outcome in people with recent-onset schizophrenia

Conditions: Schizophrenia

Summary: this study will determine the effectiveness of combining antipsychotic medication with individual placement and support (ips) and group training with the workplace fundamentals module or brokered vocational rehabilitation in facilitating the search for appropriate work or schooling and maintaining work or school activities in people with recent-onset schizophrenia.

the purpose of this protocol is to test, in recent-onset schizophrenia, the efficacy of a rehabilitative intervention that is designed to enhance the search for appropriate work or schooling and to increase ability to maintain work or school activities more successfully. predictors of work outcome are being assessed in the context of this work rehabilitation and treatment with the second-generation antipsychotic medication, risperidone. the developmental processes in schizophrenic disorders project involves an ongoing series of longitudinal follow-through studies of individuals with a recent onset of schizophrenia. the current protocol focuses particularly on processes affecting work outcome in this initial period after onset of schizophrenia, drawing on findings that link cognitive deficits in schizophrenia to functional outcome. the protocol is determining the effects on work outcome of a rehabilitative intervention designed to enhance search for appropriate work or schooling and to increase ability to maintain work or school activities more successfully. all entering patients are placed on a common antipsychotic medication, oral risperidone, and are provided clinical treatment by a psychiatrist and a case manager. participating patients are randomly assigned to a combination of individual placement and support (ips) and group training with the workplace fundamentals module or to a brokered vocational rehabilitation model. the protocol is examining the predictors of level of work functioning attained in the context of the work-focused intervention and maintenance on risperidone. potential neurocognitive and environmental predictors of work and social functioning and clinical course are being examined. aspects of early perceptual processing, allocation of attention, working memory, secondary verbal memory, and conceptual flexibility that are implicated as influences on functional outcome are assessed, as are potential stresses and supportive influences in the environment.

Eligibility criteria:
inclusion criteria: * first major psychotic episode within 2 years of study entry * rdc schizophrenia or schizoaffective disorder, mainly schizophrenic subtype * residence within commuting distance of ucla * interest in trying to resume work or school * speaks english exclusion criteria: * known neurological disorder * significant and habitual drug abuse or alcoholism within 6 months of psychotic episode or evidence that substance abuse will be a prominent factor in course of illness * mental retardation * treatment with risperidone is contraindicated

Keywords: work outcome supported employment social skills training risperidone cognition first-episode schizophrenia
predictive and impact of pain after 6 months of radiotherapy, in head and neck cancer

Conditions: Neuropathic Pain; Anxiety Disorder/Anxiety State; Pain, Chronic; Alcohol Use Disorder; Psychoactive Substance Use; Sleep; Symptoms and Signs; Addiction Nicotine

Summary: head and neck cancers are a source of complications and after-effects related to the disease and treatment. these cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological components. chronic pain affects 36% of patients at 6 months and 30% after this period. these pains are responsible for the consumption of level ii and iii analgesics in 53% of these patients. at the same time, after the end of treatment, nearly a quarter of patients continued to smoke and half still consumed alcohol at least twice a week. the hypothesis of this research is to investigate the correlation between pain and the continuation of addictions, the occurrence of depressive states, asthenia and the alteration of the patients' global quality of life. the investigators propose a two-center prospective cohort study to evaluate this hypothesis at 6 months after radiotherapy treatment. this study is planned to include 120 patients with a first head and neck cancer whit radiotherapy as part of their treatment sequence. the expected duration of inclusion is 18 months. the identification of factors affecting survival, quality of life and patient compliance is essential to determine appropriate management, particularly by creating appropriate therapeutic education programs.


Eligibility criteria:
inclusion criteria: * patients with a first head and neck cancer whose therapeutic sequence involves radiotherapy * patient over 18 years of age * having given written consent * patient not previously treated with radiotherapy * life expectancy \> 3 months * world health organization (who) score \< 3 * histologically proven head and neck cancer * stable patient, with no signs of recurrence or other progressive neoplasia at the time of the examination * patient treated with radiotherapy * patient fluent in french exclusion criteria: * non-consenting patient * history of malignancy, other than treated and cured basal cell or cervical cancer * patient who has had a salvage surgery other than lymph node removal * patient with evidence of recurrence or other progressive neoplasia at the time of examination * patient who has had previous mutilating surgery (causing sequelae of swallowing and eating) * uncontrolled infectious pathology * patient under 18 years of age * patient who is not fluent in french * patient with a psychiatric pathology that could disrupt the study or prevent the interpretation of the results.

Keywords: head and neck cancer pain quality of life addiction depression
technology and system for minimally invasive tka surgery robot

Conditions: Osteoarthritis, Knee

Summary: developed a robot for minimally invasive tka surgery and prepare for the subsequent cfda application of the minimally invasive total knee replacement robot system.

1. for the current minimally invasive total knee arthroplasty, due to the limitation of the surgical field of view and the scope of operation, and the error of the intraoperative osteotomy saw, it can cause intraoperative damage to ligaments, nerves and blood vessels, postoperative lower limb force lines and prosthesis position poor, abnormal movement and force of the patellofemoral joint and tibiofemoral joint after surgery can easily lead to clinical symptoms such as rapid wear of the prosthesis, short service life, postoperative knee pain, and even possible problems with surgical failure and revision. developed a robot for minimally invasive total knee replacement surgery. minimally invasive total knee arthroplasty is performed by surgical robot and manual operation. according to intraoperative and postoperative imaging observations, the position of the prosthesis, and the evaluation of soft tissue balance during and after the operation, the two methods are compared with the surgical robot and manual operation. kind of surgery. 2. to prepare for the subsequent cfda application of the minimally invasive total knee replacement robot system.

Eligibility criteria:
inclusion criteria: 1. no surgery on the knee joint. 2. age\>55 exclusion criteria: 1. knee surgery history. 2. severe knee joint deformity (valgus greater than 15° or valgus greater than 20°) or knee joint instability. 3. severe flexion contracture deformity. 4. revision and replacement surgery for knee joints.

Keywords: koa tka robotic surgery
comparison between conventional and cad/cam complete dentures designed based on neutral zone concept

Conditions: Missing Teeth; Dentures

Summary: a within-subject cross-over study is done on eight completely edentulous patients to compare two different complete removable dentures. group i: heat cured conventional complete dentures designed based on the neutral zone concept; group ii: cad-cam neutral zone complete dentures designed based on the neutral zone concept. occlusal analysis is done by the t-scan device, and evaluation of muscle activity is conducted by electromyography at insertion time, two weeks after insertion time, and one month after insertion time.

this study is designed as a randomized clinical trial applying a within-subject comparison of two different complete denture types as follows; group i: heat cured conventional complete dentures designed based on the neutral zone concept, group ii: cad-cam neutral zone complete dentures designed based on the neutral zone concept. the study will be carried out on eight completely edentulous patients, each patient will receive two sets of complete dentures in a random sequence. for each denture set, at the denture insertion visit occlusal analysis and equilibration will be performed with the aid of the t-scan device, also emg evaluation of muscle activity will be conducted. two weeks after, the patients will be recalled to reanalyze the occlusion after the denture settles using the t-scan computerized system. one month after the last recall visit, the emg evaluation of muscle activity will be conducted again. the emg and t-scan recording data will be collected and analyzed to compare the two denture types

Eligibility criteria:
inclusion criteria: 1. patients who have been completely edentulous in both jaws (maxilla and mandible) for a long period. 2. patients with a resorbed mandibular ridge. 3. patients with a class i maxillo-mandibular relationship 4. patients with adequate inter-arch space. 5. patients with good neuromuscular control. 6. patients without any tempo-mandibular disorder. exclusion criteria: 1. patients with any oral diseases that may affect complete denture construction 2. patients with bad oral hygiene. 3. patients with neuromuscular disorders. 4. patients with a history of parafunctional habits. 5. hysterical patients. 6. patients will undergo or have previously received chemotherapy or radiotherapy. 7. drug-addicted patients.

Keywords: cad-cam denture, complete electromyography
brain-derived neurotrophic factor and cogntive function

Conditions: Cognitive Dysfunction; Glucose Metabolism; Low-grade Inflammation; Bodycomposition

Summary: individuals with type 2 diabetes have an increased risk of developing cognitive dysfunction followed by dementia in late life. obesity, physical inactivity and "systemic low-grade inflammation" are strong risk factors and play a crucial role in this network of diseases. brain-derived neurotrophic factor (bdnf) is produced in brain as well as several tissues outside brain eg muscle cells. low bdnf are associated with cognitive dysfuction, obesity and type 2 diabetes. the investigators include 200 individuals divided into three groups: 80 individuals with type 2 diabetes, 80 age and bmi-matched controls and 40 individuals with impaired glucose tolerance. the project will test the hypothesis, that low systemic bdnf are associated with accumulation of abdominal fat, cognitive dysfunction and insulin resistence with different effect in men and women.

methods: 200 individuals in age 40-65 years are recruited and categorized into 3 groups: 1. type 2 diabetes, 2. impaired glucose tolerance and 3. normal glucose tolerance. groups are supposed to be age and bmi-matched. measurements of systemic bdnf, cogntive function (memory, attention and langue), fitness, bodycomposition, glucose metabolism and systemic inflammation are done. multiple regression analysis are perfomed to explain variablity in cognitive function, with age, visceral fat and bdnf as explanotory varibales.

Eligibility criteria:
inclusion criteria: * 40-65 years of age exclusion criteria: * chronic inflammatory diseases or infectious diseaases within 3 month prior to visit * fasting glucose \> 12 mmol/l * hypertension: systolic \>180 mmhg and diastolic \>110 mmhg * intake of more than 2 oral antidiabetic drugs or any tzd drung within 3 months before recruitment

Keywords: brain-derived neurotrophic factor low-grade inflammation cognitive dysfunction
a trial to investigate the pharmacokinetics (pk) of single doses of 200 µg, 400 µg and 2 x 400 µg of intranasal fentanyl spray (infs) in healthy subjects

Conditions: Healthy Volunteers

Summary: the overall clinical trial objective is to gain information about the pharmacokinetics (pk) of a 400 µg dose strength of infs using a population pk (poppk). in total, 20 healthy male and female subjects are planned to be randomized in the trial. subjects will be randomized to one of two treatment sequences and treated with 3 different dosages (either 200 µg/dose infs, 400 µg/dose or 400 µg two doses administered 10 minutes apart) over two days. subjects will be hospitalized over a period of total 5 days, where safety assessments and pharmacokinetic samplings will be conducted.


Eligibility criteria:
eligibility criteria: healthy male and female caucasian or black subjects between 18 and 55 years with a body mass index of 18-28 kg/m2 and a minimum weight of 50 kg.

Keywords: intranasal fentanyl spray population pk
do penicillin-allergic patients presents a high risk of sinus lift failure

Conditions: Maxillary Sinus Disease

Summary: this retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.

introduction: it is known that patients allergic to penicillin have a tendency to have greater failure of dental implants. it is believed that when prescribing non-penicillin antibiotics, such as clindamycin, the bacterial spectrum is not as wide as penicillin, and it is commonly associated with more drug-resistant microorganisms, such as cloastridium difficile. however, this statement, which is well studied in implants, has not been studied as much in sinus lift as a surgical technique. objectives * primary objectives: for that reason, the primary objective of this study is to evaluate retrospectively, if penicillin allergic patients presents higher risk of failure in lateral sinus lift procedure compared to none-allergic penicillin patients. * secondary objectives: evaluate the differences, in terms of implant failure and intraoperative and post-operative sinus lift complications, between patients allergic to penicillin and those who are not allergic. materials and methods: this retrospective study analyzed patients undergoing lateral sinus lift and rehabilitated with dental implants between the years 2004 and 2024 at the dental clinic of universitat internacional de catalunya, barcelona (uic). this study will include adult patients in whom a lateral sinus lift with simultaneous or delayed implants was performed at the university. the clinical history should determine whether or not you are allergic to penicillin, the possible pre- and post-operative complications of the surgical intervention and the evaluation regarding the sinus lift surgery (whether it fails or not) and the subsequent placement of the implant.

Eligibility criteria:
inclusion criteria: men and women over 18 years of age, patients undergoing at least one sinus lift procedure with simultaneous or deferred placement of implants; and patients' containing the following data: (1) penicillin allergy: presence or absence; (2) prescribed antibiotic guidelines; (3) intraoperative complications: no complications, schneider membrane's perforation; (4) postoperative complications: no complications, fistula, infection, unspecific failure, hemorrhage, healing by second intention; (5) results of sinus lift procedure: failure or not; (6) results of implant placement: failure or not. exclusion criteria: (1) medical history that was not fully complied with; (2) patients who did not attend follow-up visits.

Keywords: penicillin allergy dental implant sinus lift failure
study of efficacy and tolerability of various bowel preps in diabetic patients

Conditions: Diabetes Mellitus

Summary: poor bowel preparation and patient intolerance of the procedure are the most important factors contributing to the limitation of colonoscopy. inadequate bowel cleansing results in incomplete testing, increased potential to miss lesions, increased cost, and decreased patient satisfaction. the investigators hope to gain better insight into which bowel preparation works best in diabetic patients and hence would increase patient satisfaction, tolerability of the bowel preparation and decrease overall costs. the investigators will investigate which bowel preparation for colonoscopy will work optimally in diabetic patients using three different regimens.


Eligibility criteria:
inclusion criteria: * adult diabetic outpatients referred for elective colonoscopy exclusion criteria: * patients \ 75 yrs of age, * known or suspected pregnancy, * known or suspected renal failure, * unstable angina, * acute coronary syndrome, * decompensated congestive heart failure, * decompensated liver failure, * known or suspected bowel obstruction, * major psychiatric illness, * solid organ transplant patients, * known allergies to peg-els or bisacodyl, * prior alimentary tract surgery or refusal to consent to the study.
effect of tactile-kinesthetic stimulation on preterm neonates

Conditions: Infant, Premature, Diseases

Summary: an interventional study to evaluate the effect of tactile-kinesthetic stimulation (tks) on growth, neurobehavior and development among preterm neonates in the neonatal unit of dr. cipto mangunkusumo hospital.

preterm neonates were recruited via random sampling and divided into two groups (intervention group and control group). a written informed consent was obtained from the parents or guardians. before the intervention, physical examination was performed to ensure the neonates had normal vital signs, were healthy and did not present with congenital abnormalities. in the intervention group, tks was performed with specific baby oil for 15 minutes, three times a day, for 10 days. after 10 days, tks was applied once daily by the mother or caregiver. tks implementation at home was supervised by the investigator or nurse through phone call. the tks were documented by the mother or caregiver in the diary card, which should be brought during the next visit when the neonate was 11-14 days old. in addition to tks, history of illness and nutrition which was confirmed through history taking during hospital or home visit, was also recorded. the participants who did not go the hospital were home visited by the investigator or nurse. anthropometric measurement by investigator and trained nurses and dubowitz examination was performed by investigator in a warm and quiet place in the neonatal unit, mother-baby unit, outpatient clinic or participants' home while the neonate was fully alert. at 3 months of age, infant development was assessed by the investigator using the capute scales (developmental quotient of clinical adaptive test \[dq cat\], clinical linguistic adaptive milestone scale \[dq clams\]) and the full scale developmental quotient (fs dq) score. the clinical linguistic adaptive milestone scale (clams) score was based on the parent's report of language skill attainment. the clinical adaptive test (cat) score was based on the child's performance according to the listed items.

Eligibility criteria:
inclusion criteria: * 6-24-hour-old preterm infants with 32-\<37 gestational weeks * birth weight ranging from 1,500 to \<2,500 g * appropriate for gestational age * a minimum apgar score of seven at the fifth minute * no history of neonatal resuscitation * stable vital condition * no invasive therapy during hospitalisation exclusion criteria: * intrauterine growth retardation * untreated clinical sepsis * congenital abnormalities such as congenital heart disease * history of hyperbilirubinemia

Keywords: preterm growth development premature birth infant massage weight gain