Kornimate/medical-research-clean huggingface dataset:
physical capacity of spina bifida and factors affecting

Conditions: Spina Bifida

Summary: objective: it was aimed to evaluate the physical characteristics of the cases with spina bifida and to review the factors that may affect the etiology of the disease. methods: 48 cases with spina bifida and 48 control groups in other disease groups evaluated. a physiotherapist physically evaluated the cases after their personal information was obtained. a survey form examining the possible factors in the etiology of spina bifida was applied to the families.

the study was carried out with the participation of 48 cases with spina bifida between the ages of 0 and 2 evaluated in xxxxxx training and research hospital (xxxxx) pediatric clinics and 48 control groups in other disease groups in response to each case. the case group consisted of patients who were diagnosed in the neonatal intensive care unit between february 2019 and january 2020 (39 children), and who applied to the physiotherapy and rehabilitation department from the centers outside for physiotherapy needs (9 children).

Eligibility criteria:
inclusion criteria: * spina bifida between the ages of 0 and 2 exclusion criteria: * control group was formed through random selection among the children who were at the same age group between the same dates, did not have any diseases related to the neuromuscular system, and hospitalized for any other reason.
transition from buphenyl to ravicti for the therapy of byler disease

Conditions: Byler Disease

Summary: this is a single patient compassionate use protocol to determine whether ravicti will improve bile flow in a subject who previously tolerated therapy with buphenyl.


Eligibility criteria:
inclusion criteria: * byler disease * cholestasis * tolerance of buphenyl therapy exclusion criteria: * allergy/hypersensitivity to ravicti
study of effectiveness of thoracic epidural analgesia for the prevention of acute pancreatitis after ercp procedures

Conditions: Post-ERCP Acute Pancreatitis

Summary: for 40 years, the post-ercp (endoscopic retrograde cholangiopancreatography) pancreatitis has been the most frequent adverse effect of endoscopic transpapillary interventions. we sought to determine the efficacy of thoracic epidural analgesia for the prevention of post-ercp pancreatitis. between 2008 and 2013, a randomized study of the results of endoscopic treatment of 491 patients was conducted. the first group of patients (n=247) received thoracic epidural analgesia (tea) during ercp procedures, the patients of the second group (n=244) received a narcotic analgesic. to detect statistically significant differences between research groups adjusted odds ratios (or) and their 95% confidence interval (ci) were calculated.

preoperatively the subjects were randomly assigned (by using sealed envelopes - blind randomization) into two groups, 250 patients each. the patients of the first group had tea applied during the ercp procedure; other methods of pain relief were applied to the patients of the second (control) group. the first group (tea group) of patients received the following premedication: atropine sulfate 0.5-1 mg, midazolan 5 mg. the puncture and catheterization of the epidural space was carried out according to standard procedure between thoracic vertebrae vii-viii. half an hour before performing ercp ropivacaine 0.5% -10 ml. was injected into the epidural space. the second group (control group) of patients received the following premedication: atropine sulfate 0.5 -1 mg, midazolan 5 mg, trimeperidine 2% -1 ml.

Eligibility criteria:
inclusion criteria: * patients with performed therapeutic ercp; * the ercp procedure was performed in a patient for the first time; * prior to the ercp procedure the patient didn't have any clinical signs of acute pancreatitis. exclusion criteria: - development of complications during the ercp procedure that required urgent surgical intervention (massive haemorrhage, dormia basket avulsion and others).

Keywords: therapeutic ercp prevention of post-ercp pancreatitis thoracic epidural analgesia
hepatitis b virus infection after liver transplantation in children

Conditions: Hepatitis B Infection

Summary: china is a highly prevalent area of hepatitis b virus（hbv） infection, with at least 75 million hepatitis b virus carriers, and 80% of primary hepatocellular carcinoma (hcc) is associated with chronic hepatitis b virus infection. liver transplantation is currently the preferred method for end-stage liver disease such as biliary atresia and cirrhosis in children. in recent years, children's liver transplantation has developed rapidly and the number of developments has increased significantly. if there is chronic hepatitis b virus infection in the donor liver, it may cause hbv transmission, or the patient may have a low-load occult hepatitis b virus infection, and after immunosuppressive treatment, it may lead to hepatitis b virus infection after surgery.


Eligibility criteria:
inclusion criteria: * patients with end-stage liver disease who require liver transplantation exclusion criteria: * children without liver transplantation refer to children; * children who are unwilling to participate;
reducing the experience of menopausal symptoms through temperature

Conditions: Hot Flashes; Menopause

Summary: the purposes of this study are to obtain preliminary evidence on the efficacy of a cooling mattress pad in reducing subjective hot flashes for peri and postmenopausal women experiencing menopausal hot flashes, and to obtain preliminary evidence on the efficacy of a cooling mattress pad for improving sleep for peri and postmenopausal women experiencing menopausal hot flashes.

women will be recruited from the community through flyers. they will call into a study phone line at which time they will be screened for their initial eligibility using a telephone screener. women who are eligible and willing to participate, will either come to the research center in winston-salem to be consented and complete baseline questionnaires or complete these by mail or email. after two weeks, women will mail back their diaries and continue to record their daily hot flashes until they are notified by study staff of their eligibility, within a week of receiving the diary. if they qualify, a cooling mattress pad will be provided by study staff to be used for the duration of the intervention phase for approximately 8 weeks. the study staff will determine the efficacy of the cooling mattress pad through comparing answers to subject questionnaires at baseline and follow up in addition to comparing the baseline diaries to the intervention diaries.

Eligibility criteria:
inclusion criteria: * women aged 45-60 * peri or postmenopausal women (no periods for at least 3 months) * experiencing at least 4 hot flashes per day on average per week exclusion criteria: * initiated cam or non-cam treatments for hot flashes in the last 4 weeks. * changed dose of a cam or non-cam treatments for hot flashes in the last 4 weeks * initiated antidepressants in the last 3 months. * changed their dose of an antidepressant in the last 3 months. * women who describe their health as fair or poor.

Keywords: hot flashes menopause cooling mattress pad
sleep enhancement training study for novice shiftworkers

Conditions: Shift-Work Sleep Disorder

Summary: the purpose of this study is to determine if a modified version of the sleep enhancement fatigue reduction training (sefrt) system can improve sleep and health-related symptoms and quality of life in shiftwork-naive new nurse graduates.


Eligibility criteria:
inclusion criteria: * english-speaking nurses scheduled to work at least 2 consecutive night shifts per week in the next 2 months exclusion criteria: * \> 6 months experience working night-shift * current diagnosis of sleep disorder or affective illness

Keywords: shift-work sleep nurse relaxation
an informational and supportive care intervention for patients with locally advanced rectal cancer

Conditions: Rectal Cancer; Self Efficacy

Summary: the aim of this study is to evaluate the feasibility and acceptability of conducting a randomized trial of a brief psychoeducational intervention versus enhanced usual care for patients with locally advanced rectal cancer who are initiating neoadjuvant multimodality treatment.

this is a randomized controlled trial that is split into two phases. study phase i tested the feasibility and acceptability of a study evaluating a psychoeducational intervention relative to a control condition for improving self-efficacy in patients with locally advanced rectal cancer initiating multimodality treatment. this phase enrolled 20 participants. study part 2 was initially planned as an adequately powered rct to evaluate intervention efficacy for enhancing patient self-efficacy for managing treatment-related challenges and maintaining quality of life. due to the substantial refinements that were made to the pathways intervention and study procedures after study part 1, we have elected to change study part 2 to a second pilot randomized controlled trial to evaluate the feasibility and acceptability of the refined pathways study among a larger group of patients (n=60). participants in the intervention arm will be invited to receive the pathways intervention, including 4 coaching sessions with a study clinician focused on information and support related to multimodality treatment for larc. participants in the control arm will receive an information resource guide that is tailored for patients with larc. it is expected that about 80 people will take part in this research study.

Eligibility criteria:
inclusion criteria: 1. age≥18 years 2. within 8 weeks after documented decision to pursue multi-modality therapy for newly diagnosed larc (i.e., stage ii or iii disease) 3. able to complete study procedures english or with the assistance of an interpreter exclusion criteria: 1. comorbid health condition that would interfere with study participation, as identified by cancer care team 2. has undergone treatment for a prior colorectal cancer

Keywords: total neoadjuvant therapy locally advanced rectal cancer self efficacy psychoeducational multimodality treatment
central mammary duct excision; how to improve the outcome?

Conditions: Duct Ectasia Breast; Benign Breast Disease

Summary: the study compares two surgical techniques in excision of the central duct system of the breast. known also as major duct excision

first technique used is the original hadfield techniques. the other technique is almasad technique published in 1999. in this technique, de-epithelialization of a supraareolar area of nearly 2cm is done and elevation of the nipple areola complex is done to support the retroareolar area.

Eligibility criteria:
inclusion criteria: females with nipple discharge / recurrent peri-ductal mastitis - exclusion criteria: * suspicion or evidence of malignancy
effect of aquatic training on motor function in children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: clinically, infants with autism spectrum disorder often display gross motor delays in supine, prone, and sitting skills in their first year of life . studies reveal that motor abnormalities in autism spectrum disorder can occur very early in developmental trajectory.

hydrotherapy is an environment that may be conducive to encouraging physical activity in children with autism spectrum disorder. the buoyancy of water can assist with movement, balance, and coordination .water also provides an opportunity for social interaction through aquatic games and activities.based on the literature, aquatic therapy appears to be particularly beneficial for children with autism spectrum disorder who need strong sensory stimulation.

Eligibility criteria:
inclusion criteria: * age ranges from 3 to 5 years. * mild to moderate autistic features according to gars (scores from 60 to 110). exclusion criteria: * significant visual or auditory defects. * history of cerebral palsy or psychiatric disorder (e.g attention deficit hyperactivity disorder). * open wound. * dermatological diseases

Keywords: autism spectrum disorder aquatic therapy motor development land exercises
kinesiotaping and constraint induced movement therapy in subacute stroke

Conditions: Stroke

Summary: in stroke patients, the most common neurological deficits were motor impairment, loss of somatosensation, abnormal muscle tone, and impaired fractionated movement at affected limbs. therefore, the investigators try to facilitate upper extremity function and normalize the muscle tone to enlarge their capacity to perform daily activities and to improve life quality by modified constraint-induced movement therapy (mcimt) and kinesiotaping (kt). the investigators will collect 90 subacute stroke patients with hemiplegia in this study. these 90 patients will be randomly divided into 3 groups. in kt group (n=30), the patients will perform kinesiology taping for 5 days per week for 3 weeks. in mcimt group (n=30), the patient will receive constraint the unaffected limb for 2 hours a day, 5 days a week for three weeks. in kt+mcimt group, the kt and mcimt interventions would be performed for 5 days a week in three weeks. all the patients in kt, cimt and kt+mcimt groups will receive 20-minute hand function training twice daily for 5 days per week for 3 weeks. before intervention, immediately and 3 week later after intervention, all patients will receive the physical examinations including motor recovery stage (brunnstrom stage), spasticity (modified ashworth scale and tardieu scale), and sensation. fugl-meyer assessment for upper extremity (fma-ue), box and block test, simple test for evaluating hand function (stef), and wolf motor function test for hand function, adl and quality of life assessment and musculoskeletal sonography for affected forearms will be also evaluated in this study. the aims of this study are: 1. to investigate the effect of kinesiotaping and modified cimt in improving upper extremity function and spasticity for subacute stroke patients with hemiplegia. 2. to explore the role of sonoelastography and shear wave velocity in poststroke spasticity assessment.


Eligibility criteria:
inclusion criteria: * the patients have a stroke with hemiplegia (duration is 3\~12 months after stroke). * patients who are able to perform hand grasp. * patients who could slightly do fingers extension and minimal wrist extension. (ability of extension at least 10 degrees at the metacarpophalangeal and interphalangeal joints and 20 degrees at the wrist.) exclusion criteria: * age is younger than 18 years or older than 80 years * previous history of upper extremity tendon or neuromuscular injury * any other systemic neuromuscular disease * cognition or language impairment leading to communication difficulty * allergy history when application of kt materials

Keywords: stroke kinesiotaping constraint induced movement therapy sonography
a comparative evaluation of nottingham hip fracture score (nhfs) and acute physiology and chronic health evaluation (apache) ii score to predict 30-day mortality in geriatric patients above 60 years undergoing hip fracture surgery.

Conditions: Geriatric Hip Fracture

Summary: this study aims to compare the nottingham hip fracture score (nhfs) and the acute physiology and chronic health evaluation ii (apache ii) score in predicting 30-day mortality in geriatric patients over 60 years old undergoing hip fracture surgery.

the study aim to compare the nottingham hip fracture score (nhfs) and the acute physiology and chronic health evaluation ii (apache ii) score in predicting 30-day mortality in geriatric patients over 60 years undergoing hip fracture surgery. this study was conducted at the tata main hospital in jamshedpur, india. the study was designed as a prospective observational study, with data collected from june 2022 to june 2023. the study's primary objective was to predict mortality in patients undergoing hip fracture surgery. the study also investigated secondary outcomes such as the need for postoperative ventilator and ionotropic support, the occurrence of acute kidney injury, cardiac morbidity, and the presence of pulmonary embolism and deep vein thrombosis, as well as length of stay.

Eligibility criteria:
inclusion criteria: age more than or equal to 60 years, underwent hip fracture surgeries, of either sex - exclusion criteria: age less than 60 years of age, hip fractures not undergoing any invasive surgery, implant removals planned for healed hip fractures, re-explorations during the same admission in which primary surgery was conducted -

Keywords: geriatrics hip fractures apache ii mortality morbidity
bisphenol a and muscle insulin sensitivity

Conditions: Insulin Sensitivity; Glucose Metabolism Disorders; Microtia

Summary: this study examine oral bisphenol a consumption on muscle insulin sensitivity and hepatic glucose suppression. half of the participants will receive a diet plus bpa and the other half will receive a diet plus no bisphenol a.

evidence linking bisphenol a exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol a to type 2 diabetes remains unclear. the investigator's preliminary data suggests that in young adults, single oral bpa consumption significantly decreased glucose, insulin, and c-peptide responses to an oral glucose tolerance test, suggesting that immediate consumption of bisphenol a has an effect on muscle insulin sensitivity, hepatic glucose suppression and/or digestion and absorption to lower blood glucose, insulin, and c-peptide concentrations. the present experimental study evaluating the effects of bisphenol a over several days on the pathogenesis of type 2 diabetes will directly assess each of these potential mechanisms using gold standard measures (euglycemic hyperinsulinemic clamp technique and hepatic glucose suppression with glucose stable isotope infusion, and fecal microbiota).

Eligibility criteria:
inclusion criteria: * non-dieting * sedentary (≤3 hour/week of aerobic exercise) * normal-weight (bmi = 18.5 to 24.9 kg/m2) * weight-stable for the previous 6 months * free of any metabolic or chronic disease * non-smoking, and sedentary exclusion criteria: * hemoglobin a1c based on the american diabetes association guidelines of 5.7 to 6.4% (prediabetes) or \>6.4% (diabetes) * impaired glucose tolerance * type 1 diabetes * type 2 diabetes * colitis or any inflammatory bowel condition * neurologic or psychiatric conditions * smoking * special diets (e.g. vegetarian, low-carbohydrate, paleolithic, etc.) * pregnant women or women trying to become pregnant

Keywords: bisphenol a diet
effects obtained at manual function after applying anodic transcranial direct current stimulation (tcds) in children with spastic hemiparetic cerebral palsy

Conditions: Hemiparetic Cerebral Palsy

Summary: spastic hemiparetic cerebral palsy (shcp) uses to limit the manual function. using anodic transcranial direct current stimulation, it is possible to activate certain cerebral areas depending on where the electrodes are. this study will use this kind of stimulation on the contralateral primary motor cortex of the affected upper limb and analyze the effects.

it has been designed a single-arm prospective longitudinal quasi-experimental pilot clinical study following the spirit 2013 statement. it will value the time that the children spend doing the bimanual activities described by the children's hand-use experience questionnaire (cheq), it will also value the subjective experience doing those activities; it will analyze the active movement (fugl-meyer for upper limb), spasticity (modified ashworth), manual strength (dynamometry) and the recruitment improvement (surface electromyography) too. this study will apply the anodic transcranial direct current stimulation over 20 children between 14-18 years old. the protocol that it will follow is the next one: 3 days to value the outcome measures, 4 days (1 session per day of 17 minutes and 30 seconds) to apply the protocol of anodic transcranial direct current stimulation (0,6 ma of intensity). it will use the epte v07 bipolar system by ionclinics ®; 3 days to value the outcome measures studying the effects produced at the affected upper limb. another evaluation will be realized 3 weeks after the last session of anodic transcranial direct current stimulation to know if the effects obtained last at medium-long term.

Eligibility criteria:
inclusion criteria: * children between 14-18 years old. * children with spastic hemiparetic cerebral palsy diagnosis. * children with a cognitive level high enough to understand and to do the activities to value them. * children hemodynamically stable. * children forming part of levels ii-iv of the manual ability classification system (macs). exclusion criteria: * children with defibrillator. * children with pacemaker. * children with cerebral stimulator. * children with intracranial metallic implants. * children with opened cranial after clambering. * children that receive another treatment (pharmacological or physiotherapical) that could interfere or disrupt the results. * another circumstance where the electrotherapy treatment is contraindicated.

Keywords: cerebral palsy transcranial direct current stimulation upper limb
study on neuropsychiatric behavior in cadmium-exposed people

Conditions: Cadmium Exceeds the Standard

Summary: this study hypothesized that excessive cadmium is related to clinical pain, depression, and cognitive impairment, and that related indicators will improve after cadmium is eliminated.

this study will combine the research progress of the innovative drug gmdtc, the mechanism of nerve damage caused by cd2+ disrupting ca2+ homeostasis, imaging technology and analysis methods, and the basis of our previous research work to explore the effect of the chemical class 1 innovative drug gmdtc on the neuropsychiatric behavior of people with excessive cadmium. mechanism of action. this study is not limited to the study of the mechanism of neurotoxicity after cd2+ deposition. it will also clarify the clinical efficacy of the innovative drug gmdtc in removing cd2+ deposition in the brain and reducing damage, which is expected to open up new avenues for the treatment of cadmium neurotoxicity. this study hypothesized that excessive cadmium is related to clinical pain, depression, and cognitive impairment, and that related indicators will improve after cadmium is eliminated.

Eligibility criteria:
inclusion criteria: * age ≥18 years old, both men and women are welcome * the weight of male subjects is ≥50.0 kg, the weight of female subjects is ≥45.0 kg, and the body mass index (bmi) is between 19 \~ 26 kg/m2, including the critical value * urinary cadmium \&gt;5 μmol/mol creatinine for 2 consecutive days (creatinine content is ≥0.3 μg/l and ≤3 μg/l) * right-handed * voluntarily participate in this study and sign informed consent. exclusion criteria: * combined with other neurodevelopmental problems (such as autism), organic brain mental disorders (such as alzheimer\&#39;s disease, parkinson\&#39;s disease, etc.) and organic brain diseases (such as cerebral hemorrhage, infarction, etc.) that meet the dsm-5 diagnostic criteria ) * those who have suffered from or are currently suffering from any serious clinical diseases that pose safety risks such as circulatory system, endocrine system, nervous system, digestive system, respiratory system, hematology, immunology, psychiatry and metabolic abnormalities * continuous use of high-dose neuroleptics in the past 3 months (high-dose: daily dosage of benzodiazepines ≥ 4 mg lorazepam equivalent; long-term: the total duration of use is at least 60 days) * have contraindications for mri or bone density examination (pacemaker or defibrillator, artificial heart valve, clothing containing fluorescein, iron, etc.) * pregnant and lactating women * those who cannot tolerate venipuncture and/or have a history of fainting from blood or needles * those with egfr \<30 ml/min/1.73 m2 during screening (egfr is calculated using the cockcroft-gault formula: egfr(ml/min/1.73m2) = (140-age)\*weight (kg)/\[0.818\*cr(μmol/l )\]\*0.85(female))

Keywords: cadmium cadmium exceeds the standard neuropsychiatric behavior neuroimaging cognitive impairment