Kornimate/medical-research-clean huggingface dataset:
increasing covid-19, influenza, and pneumonia vaccine uptake

Conditions: Covid19; Influenza; Pneumonia; Vaccine Refusal

Summary: this proposed study seeks to community knowledge and understand the experience of underserved communities in the exploration of reducing health disparities and increasing vaccine uptake and acceptability covid-19, influenza, and pneumonia for aa and latinx populations. unique in its design, it has the following characteristics: 1) multifaceted, 2) culturally tailored, 3) community-based, and 4) mixed methods in which the outcomes of interest will be measured before and after the intervention with 18-month interval. furthermore, we seek to enhance our partnerships and collaborations with churches in south los angeles by supporting efforts to encourage covid-19, influenza, and pneumonia vaccination uptake among underserved minorities in one of the most challenged and hard-to-reach population areas in the nation.

this study seeks to augment community knowledge and increase vaccine uptake among under-resourced african american and latinx communities in south la via leveraging trusted church leaders, educators and influencers to delivering covid-19, influenza, and pneumonia education on vaccination. unique in its design, this study has the following characteristics, beneficial to the acceptability and success of the proposal, it is: 1) multifaceted, 2) culturally tailored, and 3) community-based, in which the outcomes of interest will be compared longitudinally between arms 1-3, including measurement before and after the intervention with 9- and 18-month interval.

Eligibility criteria:
inclusion criteria: * parishioner at a church receiving the vepmp intervention * identify as african american or latinx, * at least 65 years and older * have not received a vaccine for covid-19, influenza, or pneumonia within the previous 24 months * agrees to study terms, which include follow-up interviews 9 and 18 months after study enrollment exclusion criteria: * does not attend or identify as a parishioner at a church receiving the vepmp intervention * does not identify as african american or latinx * under the age of 65 years * received all vaccine doses for covid-19, influenza, or pneumonia within the previous 24 months

Keywords: african american latinx vaccine hispanic latino covid19 vaccine
low back study to compare traditional physical therapy with combined therapy protocol

Conditions: Radiculopathy; Low Back Pain

Summary: the most common chronic low back pain conditions are a consequence of disc disease as well as muscular and bony etiologies. the discs degenerate and weaken, bulge and are pushed into the space containing the spinal cord or a nerve root resulting in severe pain. a common treatment is then surgery. whole-body vibration combined with un-weighting traction and specific manual mobilization plus active therapeutic exercise seems to treat chronic low back pain by non-invasively firing muscles of the lumbar spine. the investigators are seeking to show such therapy reduces the need for surgery and significantly out performs traditional physical as the preferred conservative treatment.

patients will be placed randomly in the control group and will receive 10 weeks of standard physical therapy or in the study group and receive an equivalent 10 weeks therapy utilizing vibration, unweighting, therapeutic exercise and manual mobilization. the study uses a baseline mri and x-rays which have shown the justification for surgical intervention and during the course of the protocol will have repeat mri's and x-rays to determine any statistical change in the lumbar spine resulting in reduction or elimination of pain, improved range of motion, improvements in performance and reduction or elimination for the need for surgical intervention. anatomical measures will be done comparing pre-treatment versus post-treatment and will include foraminal dimensions,disc height, canal stenosis, lumbosacral angle and facet spacing. questionnaires will be completed during the course of the treatment and post-treatment at 6 months and one year. the final follow up phone call to the patient will be made following 24 months post initial treatment to determine the current patient status pertaining to low back pain, subsequent treatment, surgery, etc. final study documentation will occur at that time. intermediate results at one year will compare the control group vs. the study group for overall result differences.

Eligibility criteria:
inclusion criteria: * mri of the lumbar spine showing symptoms and severity to qualify for surgery * 25 to 65 years of age * diagnosis of low back pain for 3-12 months * potential surgical candidates but not mandatory exclusion criteria: * any medical or physical conditions deemed unacceptable by the participants physician or health care provider * evidence of progressive or debilitative medical conditions i.e. metastatic cancer, major stroke, crippling arthritis, unstable angina, orthostatic hypotension, hemiplegia, multiple sclerosis or parkinson's disease. * any condition that would preclude the additional burden of a repeat mri or preclude active involvement in the protocol or physical therapy * active use of tobacco products * prior back surgery * pregnancy

Keywords: resolution of low back pain show measurable improvement in disc measurement conservative therapy vs. surgery in resolving low back pain
phaseⅰ/ⅱ study of urlc10-177 and ttk-567 peptide vaccine combined with cpg7909 in patients with esophageal cancer

Conditions: Esophageal Cancer

Summary: this is a single institution phase i / ii trial to evaluate the safety and efficacy of urlc10-177 and ttk-567 emulsified with montanide isa 51 in combination with different doses of cpg7909 in patients with advanced or recurrent esophageal cancer.

phase i: patients will be vaccinated on day 1,8,15 and 22 of each 28-day treatment cycles. on each vaccination day, the urlc10-117 peptide(1mg) and ttk-567 peptide(1mg) mixed with cpg 7909 (escalating doses: 0, 0.02, 0.1mg/kg) emulsified with montanide isa 51 will be administered by subcutaneous injection. repeated cycles of vaccine will be administered until patients develop progressive disease or unacceptable toxicity, or for maximum 2 cycles, whichever occurs first. in this phase i study, we evaluate the safety and tolerability of urlc10-177, ttk-567 and different doses of cpg7909 to determine the recommended phase ii dose of cpg7909. phase ii: patients will be vaccinated on day 1,8,15 and 22 of each 28-day treatment cycles. on each vaccination day, the urlc10-117 peptide(1mg) and ttk-567 peptide(1mg) mixed with cpg 7909 (recommended dose determined in phase i study) emulsified with montanide isa 51 will be administered by subcutaneous injection. repeated cycles of vaccine will be administered for 2 cycles. in this phase ii study, we evaluate the efficacy of this vaccine therapy.

Eligibility criteria:
inclusion criteria: disease characteristics 1. locally advanced or metastatic esophageal cancer precluding curative surgical resection and recurrent esophageal cancer 2. measurable disease by ct scan patient characteristics 1. ecog performance status 0-1 2. life expectancy \> 3 months 3. laboratory values as follows * 2000/mm3 \< wbc \< 15000/mm3 * platelet count \> 75000/mm3 * aspartate transaminase \< 150 iu/l * alanine transaminase \< 150 iu/l * creatinine \< 2.0 mg/dl 4. hla-a\*2402 5. able and willing to give valid written informed consent exclusion criteria: 1. pregnancy(woman of childbearing potential:refusal or inability to use effective means of contraception) 2. breastfeeding 3. active or uncontrolled infection 4. concurrent treatment with steroids or immunosuppressing agent 5. prior chemotherapy,radiation therapy, or immunotherapy within 4 weeks 6. clinically significant heart disease 7. decision of unsuitableness by principal investigator or physician-in-charge

Keywords: esophageal cancer peptide urlc10 ttk cpg7909
comparing the efficacy of different iron formulations: sucrosomal ferric pyrophosphate, sunactive®fe and intravenous ferric gluconate

Conditions: Iron Deficiency Anemia

Summary: the purpose of the study is to evaluate the effects of martial therapy, comparing different formulations, sucrosomal ferric pyrophosphate, sunactive®fe micronized and ferric gluconate and different ways of administration, orally and intravenous, in subjects affected by sideropenic microcytic hypochromic anemia identified by the simultaneous presence of anemia, microcytosis and hypoferremia.

background: iron deficiency anemia (ida) still remains universally a worldwide problematics. anemia is defined as a hemoglobin value \<12.0 g/dl (7.45 mmol/l). management of ida is based on martial iron supplementation. the purpose of the study is to evaluate the effects of martial therapy, comparing different formulations, sucrosomal ferric pyrophosphate, sunactive®fe micronized and ferric gluconate and different ways of administration, orally and intravenous, in subjects affected by sideropenic microcytic hypochromic anemia identified by the simultaneous presence of anemia, microcytosis and hypoferremia. trial design, methods and findings: clinical data from 106 outpatients (82.8% female and 17.2% male, mean age 50.4 years) were collected at department of internal medicine, national relevance and high specialization hospital trust, arnas civico-di cristina-benfratelli, palermo, italy. the study envisaged five arms (2 + 3). at the first two arms were assigned patients with non-severe anemia hb\> 10 g/dl (hb \<12 g/dl for women and hb \<13 g/dl for men), treated with sunactive®fe micronized or lipofer®. at the other three arms were assigned patients with severe anemia (hb \<10 g/dl) treated respectively with sunactive®fe micronized, lipofer® or with intravenous ferric gluconate infusions according to departmental protocols. the followed methodology is defined in the probe project (acronym of prospective randomized open blinded end-point). the end points will be blinded with respect to the three treatments, as it will be the statistical analysis.

Eligibility criteria:
inclusion criteria: * diagnosis of iron deficiency anemia, microcytic and hypochromic * age \>18 exclusion criteria: * diagnosis of celiac disease * patients who refuse to sign the informed consent * clinically relevant cognitive turbe * hemodynamic instability defined by the presence of low blood pressure sbp \ 100 * dyspnea after modest effort worsening over the past 10 days * oxygen peripheral saturation values \<94% * ischemic heart recent and / or lower limbs * acute conditions with subacute or at recruitment

Keywords: iron iron deficiency anemia anemia
cost of off-label antibiotics in osteoarticular infections

Conditions: Bone Infection; Joint Infection

Summary: due to the emergence of multidrug-resistant micro-organisms in patients with bone and joint infection (bji), the prescription of off-labeled antibiotics seem to be more and more common as part of routine care. these new antibiotics are, however, more expensive, and there are no precise data in france regarding the volume and cost of such off-label prescriptions in hospital, in the post-acute care structures, and in the outpatient setting. the objective of this study is to estimate the cost of using these antibiotics over 2 years for patients in a reference center for the management of complex bone and joint infection (crioac)


Eligibility criteria:
inclusion criteria: - patients having had off-label antibiotics between 2014 and 2015 to treat bone and/or joint infection, with or without implant and managed at the crioac lyon exclusion criteria: none
pharmacokinetics of vancomycin in icu patients

Conditions: Suspected Infection With Vancomycin Susceptible Bacterial Strains

Summary: vancomycin is frequently under-dosed in icu patients during the first 24-48 hours of treatment. glomerular hyperfiltration syndrome, increased drug volume of distribution, vasopressor use, male sex and hypoalbuminemia are identified risk factor for vancomycin underdosing in icu patients, among others. to date, bedside estimation of vancomycin volume of distribution is challenging, and new methods for optimizing drug administration are required. the picco device is a moderately invasive hemodynamic monitoring system, providing parameters that may help estimation of vancomycin pharmacokinetics parameter. the aim of this study is to test whether addition of hemodynamic parameters would improve pharmacokinetics modelling of vancomycin concentration in icu patients.


Eligibility criteria:
inclusion criteria: * patient hospitalized in intensive care unit * under intravenous vancomycin started during current icu hospitalization * with at least one vancomycin serum concentration available * under hemodynamic monitoring with the picco ® device exclusion criteria: * vancomycin treatment for less than 24 hours * vancomycin concentration in serum unavailable * rare comorbidities influencing vancomycin pharmacokinetics * myeloma * cystic fibrosis * burn injury on more than 20 % of the body surface * previous inclusion in present study

Keywords: vancomycin under dosage intensive care unit pharmacokinetics
stand-alone cage verus anterior plating for anterior cervical discectomy and fusion.

Conditions: Degenerative Disc Disease; Cervical Spine Degeneration

Summary: the purpose of this study is to compare the clinical results between two different techniques for acdf: 1. stand-alone acdf, which means the placement of an interbody device (cage) without anterior fixation or plating; 2. acdf with and interbody cage and anterior plating for fixation. both of these procedures are commonly performed at rush with unclear advantage of one procedure over the other. both have been associated with good to excellent clinical outcomes. the devices used in this study are approved by the food and drug administration (fda).

anterior cervical discectomy and fusion (acdf) is one the most common procedures performed by spine surgeons. although acdf with autologous bone graft and anterior plating is commonly performed, this procedure may be associated with postoperative dysphagia, significant costs and adjacent segment pathology. to address these concerns, a number of surgeons have opted to utilize an interbody cage in a stand-alone fashion with good to excellent results. however, the published data is limited and currently there in no consensus among spine surgeons regarding the best technique to achieve fusion and improve clinical outcomes in patients with degenerative disc disease in the cervical spine.

Eligibility criteria:
inclusion criteria: * patients undergoing a primary 1- to 2-level acdf (a) diagnosis: myelopathy, radiculopathy, myeloradiculopathy, stenosis, herniated nucleus pulposus, degenerative disc disease, spondylosis, osteophytic complexes, and foraminal stenosis * patients able to provide informed consent exclusion criteria: * cervical spine trauma

Keywords: anterior cervical discectomy and fusion stand-alone cage anterior plating
hemathologic and imagiologic predictors of stroke during carotid endarterectomy with regional anesthesia

Conditions: Carotid Stenosis; Carotid Endarterectomy

Summary: establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.

the authors hypothesize fgf-23 and gdf-15 could predict cerebral ischemia, postoperative complications and long term major cardiovascular events, particularly in patients developing symptomatic neurologic ischemia after circulation shutdown. establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards. clarify the pathophysiology of carotid endarterectomy-related stroke and the role of gdf-15, fgf-23, bnp and hs-troponin i and other biomarkers in the prognosis of symptomatic carotid stenosis. imagiologic markers are to be included - intima-media; gray weale plaque classification, cerebral ct peak wave velocity

Eligibility criteria:
inclusion criteria: - consecutive patients from a tertiary referral center who undergo cea for carotid artery stenosis (cs) under regional anesthesia exclusion criteria: * general anesthesia * carotid stenting
simple cognitive task after trauma

Conditions: Post-traumatic Stress Disorders

Summary: this research study is designed to investigate the effects of a simple cognitive task (a memory cue following by playing the computer game "tetris") on intrusive memories ("flashbacks") and other symptoms after a traumatic event. patients presenting to a hospital emergency department soon after a traumatic event will be randomly allocated to either the simple cognitive task intervention or control. participants will be followed up at one week and one month, and where possible 3 and 6 months. it is predicted that participants given the simple cognitive task intervention will develop fewer intrusive memories and less severe clinical symptoms than those who are not. this will inform the potential future development of a simple technique to prevent distressing psychological symptoms after a traumatic event. implementation aspects in a new hospital context will also be explored. patients use their smartphone for part of the intervention in the study.

this is an explorative pilot study, which will guide the design of a future randomised controlled trial. the main aim of the present study is not a statistical significance test, the results will be descriptive, and will include pilot analyses to obtain an estimate of effect size between groups of the current primary outcome measure.

Eligibility criteria:
inclusion criteria: * aged 18 or over * experienced or witnessed a traumatic event resulting in admission to the emergency department for example a road traffic accident (as a driver, passenger, motorcyclist, cyclist or pedestrian) * met the diagnostic and statistical manual of mental disorders, 5th edition (dsm5) criterion a for post-traumatic stress disorder (ptsd) ("the person was exposed to: death, threatened death, actual or threatened serious injury, or actual or threatened sexual violence" by "direct exposure" or "witnessing the trauma") ) * can be seen in the emergency department within 6 hours after the traumatic event * report memory of the accident * fluent in swedish * alert and orientated * have sufficient physical mobility use the intervention platform (their smartphone) to play a computer game or engage in other smartphone activities at the point of taking informed consent (i.e. sufficient use of hands). * willing and able to provide informed consent and complete study procedures * willing and able to be contacted following discharge to complete follow-up assessments * have access to an internet enabled smartphone * in addition to point above "can be seen in the emergency department within 6 hours after the traumatic event", from mid may 2019, to also include patients presenting later to the emergency department if still within 72 hours of the event exclusion criteria: * loss of consciousness of \> 5 minutes * current intoxication * report a history of severe mental illness * current substance abuse or neurological condition * currently suicidal
vestibular rehabilitation and dizziness in geriatric patients

Conditions: Dizziness

Summary: the purpose of this study is to develop effective exercise intervention to reduce dizziness and fall risk in older adults with non-specific dizziness. we hypothesize that the use of vestibular exercises can reduce dizziness and improve gaze and postural stability in older persons.

community dwelling older individuals who present to a specialty dizziness clinic (atlanta vamc or emory university) with a primary complaint of dizziness will be recruited to participate in this study. before beginning the study, the presence of normal vestibular function will be measured directly using standard vestibular function tests. individuals will be randomly assigned to the vestibular exercise group (vr) or to the control group (con). data will be collected prior to the initiation of physical therapy and at the completion of the 6-week intervention period. the vr group will perform vestibular exercises plus balance and gait exercises. the con group will perform saccadic eye movements without targets against a blank wall, as well as balance and gait exercises. the balance and gait exercises for each group will be based on identified impairments and functional limitations, as is the standard of care in physical therapy. all subjects within a group will follow the same exercise progression for the vestibular or eye movement exercises. subjects will be seen in the clinic on a weekly basis to review and modify the exercises according to a standard protocol and to reinforce compliance.

Eligibility criteria:
inclusion criteria: patients must be at least 60 years of age, seeking medical care due to dizziness and have normal vestibular function based on results of the clinical examination, rotary chair and/or caloric tests. exclusion criteria: abnormal vestibular function based on results of clinical examination, rotary chair and/or caloric tests.

Keywords: dizziness geriatrics rehabilitation vestibular rehabilitation
polish translation and validation of nbss, qualiveen and sf-qualiveen

Conditions: Spinal Cord Injuries; Multiple Sclerosis

Summary: the aim of this study is to translate, culturally adapt, and validate polish versions of the nbss, qualiveen and sf-qualiveen questionnaires.

the aim of this study is to translate, culturally adapt, and validate polish versions of the nbss, qualiveen and sf-qualiveen questionnaires in patients with spinal cord injury and multiple sclerosis.

Eligibility criteria:
inclusion criteria: * spinal cord injury patients * multiple sclerosis patients * age \> 18 exclusion criteria: * spinal shock patients * urinary tract operation in the last month * quality of life changes in the last month * urinary tract infections in the last month * bladder management changes or drug changes in the last month
an exploratory genetic study in participants with psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to evaluate the association between genetic factors and response to treatment (guselkumab, ustekinumab, adalimumab, or etanercept) and psoriasis (scaly skin rash).

this is a phase 0, exploratory (intended to be conducted early in phase 1, involve limited human exposure, have no therapeutic intent and are not intended to examine clinical tolerability), multicenter (when more than one hospital or medical school team work on a medical research study) and pharmacogenomics study in participants with psoriasis. participants who were treated in study phase 2 nct01483599 (x-plore), phase 3 nct00267969 (phoenix 1), phase 3 nct00307437 (phoenix 2) or phase 3 nct00454584 (accept), will be returning to their study site where a deoxyribonucleic acid (dna) sample will be obtained for pharmacogenomics assessment. there will be no follow-up beyond the study site visit.

Eligibility criteria:
inclusion criteria: * participants must have been randomly assigned and treated in the nct01483599 (x-plore), nct00267969 (phoenix 1), nct00307437 (phoenix-2) , or nct00454584 (accept) studies * sign an informed consent document indicating that they understand the purpose of and procedures required for this study and are willing to participate in this study exclusion criteria: * participants has any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject (for example, compromise the well-being) or that could prevent, limit, or confound the protocol-specified assessments

Keywords: cnto1959pso2001 c0743t08 c0743t09 c0743t12 psoriasis pharmacogenomics