Kornimate/medical-research-clean huggingface dataset:
development and progression of carcinoid heart disease in a cohort of adult patients with neuroendocrine tumors

Conditions: Carcinoid Heart Disease

Summary: carcinoid heart disease (chd) is a rare form of heart disease, occurring in over 50% of the patients with carcinoid syndrome. pathophysiology, prognostic factors of development of carcinoid heart disease and progression of disease remain unclear. this observational multicenter cohort study is designed to study the occurrence of carcinoid heart disease in patients with differentiated carcinoid tumors, to describe numerous factors influencing the occurrence, severity, progression and long-term survival of patients with carcinoid heart disease. basic informations and detailed diagnosis informations (oncological and cardiac parameters), are collected by professional doctors. clinical outcomes (onset of carcinoid heart disease, cardiac surgery, related death) will be followed up every year or every six/three months if clinically indicated.


Eligibility criteria:
inclusion criteria: * patients over 18 years * patients followed in a neuroendocrine tumor center with a reference cardiologist * patient with: * histologically documented metastatic well-differentiated ileum neuroendocrine tumor or * histologically documented metastatic well-differentiated bronchial neuroendocrine tumor, or * histologically documented well differentiated neuroendocrine tumor, regardless of the primitive site or unknown primitive site and presenting a carcinoid syndrome and / or an elevation of urinary 5hiaa \> 2 fold the upper limit of normal range * information given to the patient and his documented non-opposition exclusion criteria: * poorly differentiated neuroendocrine carcinoma * patient unable / unwilling to follow the cardiac monitoring recommended by good practice data * any medical, geographical, sociological, psychological or legal situation that does not allow the patient to complete the study
the efficacy and safety study of clindamycin palmitate hydrochloride dispersible tablet treatment of bacterial vaginosis

Conditions: Bacterial Vaginosis

Summary: randomized, double blind, positive drug parallel comparison, multi-centre clinical trial to assess the efficacy and safety of clindamycin palmitate hydrochloride dispersible tablet for the treatment of bacterial vaginosis

treatment group: clindamycin palmitate hydrochloride dispersible tablet . control group: metronidazole tablet.

Eligibility criteria:
inclusion criteria: 1. patients clinically diagnosed with bacterial vaginosis, should meet the following criteria: vaginal gram stain integration score (nugent score) ≥7 points 2. female patients aged 18 to 55 years old. 3. patients signed the informed consent form(icf). exclusion criteria: 1. patients with vulvovaginitis caused by other infectional reasons such as vaginitis vulvovaginal candidiasis, trichomoniasis vaginitis. 2. patients received systemic or vaginal antimicrobial therapy in a week before enrolled. 3. patients with other vaginal or vulvar disorders which could effect the evaluation of efficacy. 4. pregnant or lactating patients. 5. menopausal women. menopause definition: perimenopausal women stop menstruations for a year. 6. women with diabetes. 7. dependent on alcohol and could not prohibit during the study period. 8. women with liver and kidney disfunction, blood disorders, mental illness or other serious diseases. 9. women allergic to metronidazole, clindamycin. 10. with poor compliance.
the effect of sumatriptan and placebo on isosorbide-5-mononitrate induced headache

Conditions: Migraine

Summary: to develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting nitrogen oxide (no) donor. if the headache responds to sumatriptan, the model can be used to test new drug candidates.

there remains a great need for more effective anti-migraine drugs with fewer side effects. human experimental models are valuable in early phase development of new anti-migraine drugs but useful models have not yet been developed. the investigators' group has shown that isosorbide-5-mononitrate (5-ismn), a long lasting no-donor, induce headache/migraine in both healthy volunteers and in patients with migraine without aura (mo). to validate this model, the headache must respond to specific migraine treatment with sumatriptan. hypothesis: 5-ismn induces a migraine-like headache in both healthy subjects and in mo-patients and induced headache responds to a specific anti migraine drug; sumatriptan. aim: developing a pragmatic and valid model for the testing of new anti-migraine drugs

Eligibility criteria:
inclusion criteria: healthy: * healthy subjects of both sexes * age 18-70 years * weight 50-90 kg. * females were requested to use effective contraception. migraine patients: * migraine patients who meet international headache society (ihs) criteria for migraine with or without aura of both sexes * 18-70 years * 45-95 kg. exclusion criteria: healthy: * any type of headache (except episodic tension-type headache \< 1 day per week) * serious somatic or psychiatric disease * pregnancy * intake of daily medication (except oral contraceptives). migraine patients: * any other type of headache then migraine without aura (except episodic tension-type headache \< 1 day per week) * serious somatic or psychiatric disease * pregnancy, and intake of daily medication (except oral contraceptives).
telehealth based intervention to improve functional capacity in survivors of childhood cancer with significantly limited exercise tolerance

Conditions: Childhood Cancer; Mobility Limitation

Summary: the participants are asked to take part in this clinical trial, a type of research study. the participants are sjlife study participants and may have a hard time exercising (exercise intolerance) due to side effects of cancer treatment received as a child.this study is being done to determine if a personalized exercise plan will help childhood cancer survivors who have exercise intolerance become more active. primary objectives: to achieve the goal of this study, we propose the following three objectives: primary objective 1: to determine the efficacy of an individually tailored, home-delivered aerobic and strengthening intervention to improve exercise capacity in survivors of childhood cancer with exercise intolerance (peak oxygen uptake (peak vo2) \<85% of age and sex predicted). primary objective 2: to determine the effects of an individually tailored, home-delivered aerobic and strengthening intervention on measures of cardiac, pulmonary, musculoskeletal, and neurosensory function in survivors of childhood cancer with exercise intolerance. primary objective 3: to determine the effects of an individually tailored, home-delivered aerobic and strengthening intervention on emotional health, participation in family and community activities, quality of life, and cognitive function in survivors of childhood cancer with exercise intolerance.

the design for this study will be a single-blind two-arm, prospective, randomized clinical trial. performance testing results: both groups of participants will be provided with the results of their performance testing. individually tailored exercise program: individuals randomized to receive an individually tailored exercise program will meet with an exercise specialist.generalized exercise recommendations: individuals randomized to receive the generalized exercise recommendations will receive a copy of the physical activity guidelines for americans.

Eligibility criteria:
inclusion criteria: * between 18.00 and 39.99 years of age at the time of enrollment * sjlife participant * peak vo2 \<85% predicted * verbalizes understanding of directions for use of zoom on the study provided ipad and heart rate monitor * clearance for participation in exercise by a study physician * internet access exclusion criteria: * enrolled in a formal exercise intervention * self-report of engaging in \> 150 minutes/week of moderate physical activity * currently pregnant (assess by urine pregnancy test) * significant psychological distress (e.g. suicidal ideation) * requires immediate medical intervention (e.g. angina, decompensated heart failure) * research participant recruitment and screening
intraoperative cryoanalgesia for extended pain management following thoracotomy

Conditions: Chronic Post-thoracotomy Pain; Acute Post-thoracotomy Pain; Post-thoracotomy Pain Syndrome

Summary: the ice study study will compare standard therapy (thoracic epidural) versus a novel approach (cryoanalgesia combined with thoracic epidural) in subjects undergoing unilateral thoracotomy.

the ice study is a single institution pilot study designed to compare standard therapy (i.e., thoracic epidural) versus a novel approach (i.e., cryoanalgesia combined with thoracic epidural) to address the need for better management of acute and long-term pain in the general thoracic surgery patient population. the study's primary objective will be to demonstrate if the new intraoperative pain management approach \[i.e., intercostal cryoanalgesia in conjunction with thoracic epidural\] provides superior short-term and long-term analgesia efficacy in patients undergoing unilateral thoracotomy as compared to the current institutional standard of care (i.e., thoracic epidural). patients will be randomized in a 1:1 design.

Eligibility criteria:
inclusion criteria: * patients undergoing unilateral thoracotomy for non-cardiac surgery * age 18-85 years of age; male or female * acceptable surgical candidate including use of general anesthesia * willing and able to provide written informed consent * willing and able to return for scheduled follow-up visits exclusion criteria: * prior major surgery within the last 6-months * documented psychiatric disease * documented chronic pain syndrome * current use of prescription opioids * documented history of substance abuse * functional disability or impairment (ecog score = 0 or 1) * current pregnancy * patients currently enrolled in another research study that could directly affect results of either study * physical or mental condition that would interfere with patient's self-assessment of pain * a medical condition that in the investigator's opinion could adversely impact the patient's participation or safety, conduct of the study or interferes with the pain assessments

Keywords: thoracotomy cryoanalgesia pain
the effect of caloric supplement in the clinical outcomes in acute lung injury patients

Conditions: ARDS

Summary: the optimal amount caloric intake were still controversy in critically ill patients in literature. there were no significant outcome difference with different caloric intake in acute lung injury patients. in order to identify the optimal amount caloric intake in acute lung injury patients, we conduct a prospectively observational study to see whether the caloric differences influence hospital mortality.

the is a prospectively observational study. the data including basic demographic data, daily pn/en caloric intake, days of icu stay, days of hospital stay, hospital mortality, days of ventilator use.. will be collected. statistic analysis included chi-square, student t test, logistic regression and roc curve will be applied to analyze the different characteristics between survived and died patients. also we can figure out the optimal cut value of caloric intake with best outcome by roc curve analysis. we plan enrolled 200 participants within study period.

Eligibility criteria:
inclusion criteria: age older than 20 year old respiratory failure with ventilator fit the diagnostic criteria of ards (2012 berlin criteria) exclusion criteria: expected icu stay less than 72 hours
diagnosis and physiopathology of insulin allergy

Conditions: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hypersensitivity; Immediate Hypersensitivity; Allergy

Summary: insulin allergy (ia) is still observed even with recombinant human insulin and insulin analogs. obviously, the usual attitude facing an allergy, i. e. exclusion of the allergen, poses problems in face of ia because insulin is often vital for the patient. ia is thus a complex situation in which a rigorous diagnostic procedure to identify the exact allergen is necessary to propose a therapeutic answer; the purpose of the study is 1/ to validate a diagnostic algorithm for patients presenting with possible allergy. 2/ to investigate immunogenetic profiles of patient with insulin allergy 3/ cellular mechanisms of ia.

phenotype of the patient investigation of allergy per intradermal testing using a wide range of insulin preparations determination of immunologic and immunogenetic profile particularly cd4 + t cells and mast cells

Eligibility criteria:
inclusion criteria : * patients aged 18 years old and more with a written informed consent * experimental group : type 1 or type 2 diabetic patients with insulin allergy based on clinical criteria * active comparator group: type 1 or type 2 diabetic patients insulin treated without insulin allergy exclusion criteria : * not willing participate * pregnancy * age below 18 years * severe renal failure * severe anaphylactic shock only for the experimental group * no social security overture

Keywords: insulin allergy adverse drug reaction diabetes type 1 hypersensitivity immediate hypersensitivity type 4 hypersensitivity insulin analogs intradermal testing insulin antibody mast cell cd+ tcell
diet challenge in g6pd deficient egyptian children: a one- year prospective single center study with genotype - phenotype correlation

Conditions: Glucose-6-Phosphate Dehydrogenase Deficiency

Summary: glucose-6-phosphate dehydrogenase (g6pd) deficiency is prevalent and add a burden on families in egypt and middle east due to lifelong diet restriction, non-fava beans diet is main food for most families in the region and parents and doctors consider it as a prohibited food whatever the genetic or clinical phenotypes. the effective management is avoiding a spectrum of food and drugs causing oxidative stress. no data is available about the hazards of consumption of non-fava beans diet.

investigate the effect of challenge of non-fava beans diet on occurrence of hemolysis in both common and rare mutations causing g6pd deficiency in egyptian children as well as making a genotype-phenotype correlation. patients and methods: the study will include all g6pd deficient children who were regularly followed up in pediatric hematology center, ain shams university over last decade from 2004-2014 who stopped eating non fava-bean diet since their diagnosis as g6pd deficient and willing to participate in the diet challenge. they will be enrolled in a one year prospective study involving quantitative analyses for enzymatic activity, and molecular typing of g6pd enzyme using a polymerase chain reaction-amplification refractory mutation system (pcr-arms) technique. patient's medical records will be reviewed as history of blood transfusion and g6pd level at diagnosis. initial phase will be dietetic challenge with ingestion of non-fava beans taken in small amount (10-20 gm/day for 3 successive days ) for children with haemoglobin level ≥ 11 gm/dl with daily clinical and laboratory monitoring by complete blood count, and markers of hemolysis as well as measurement of malondialdehyde (mda) level both basal and at study end. a drop of hb of ≥0.5 gm/dl and / or appearance of hemoglobinuria is considered a significant hemolysis. patients who will not meet the definition of significant hemolysis will be prospectively followed up for one year with follow up during their chronic exposure by complete blood count and hemolysis markers/ 3 months.

Eligibility criteria:
inclusion criteria: * all children with proved enzymatic deficiency of g6pd. * patients who met the criteria of hemoglobin level at study time ≥ 11 gm/dl exclusion criteria: * patients with another enzyme deficiency

Keywords: g6pd genotype phenotype diet restriction
prognostic factors for surgical management of large hypertensive basal ganglionic haemorrhage

Conditions: Basal Ganglionic Hemorrhage

Summary: the aim of this study is to present current and comprehensive recommendations for surgical treatment of this hematoma and to determine the factors that may improve the survival rate

spontaneous intracerebral hemorrhage is a common, mostly deadly stroke subtype and accounts for 10% to 15% of all strokes. it's associated with a higher mortality rate (44% after 30 days) than either ischemic stroke or subarachnoid hemorrhage up to 75% of the long term survivors are often suffering significant disability and only 12% to 39% of the survivors have favourable neurological functions recovered rapid diagnosis and attentive management of patients is crucial because early deterioration is common neurosurgical treatment for ich has been discussed in recent multicentric studies, but no definitive answer of its utility has emerged. improved surgical techniques , neuroimaging, neuroanesthesia and perioperative monitoring and care have all led to improved outcomes from surgery

Eligibility criteria:
inclusion criteria: * 1) patients aged between 15 and 60 years old ( elderly people\>60 years were excluded since their strokes weren't routinely examined by ct scan in the emergency ward, however, in children\<15 years old was due mostly to vascular malformations 2) ct scan showed basal ganglionic haemorrhage, with or without intraventricular extension within 24 hr post ictus 3) hematoma volume was 30 ml or above 4) glasgow coma scale scores more than or equal 5 and stable vital signs exclusion criteria: * 1) intracerebral hemorrhage was caused by secondary factors e.g ( vascular malformations or head trauma) 2) gcs less than 5 or multiple intracranial hemorrhage 3) associated visceral disease e.g hepatic or renal or clotting disorder 4) patients with preexisting neurological deficit e.g previous intracerebral hemorrhage or infarction
epidemiology of hypertensive emergency

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension

Summary: to test the hypotheses that hypertensive emergency was associated with non-compliance with antihypertensive medication, low level of contact with the medical care system, and alcohol abuse and cigarette smoking. also, to describe the clinical characteristics of patients hospitalized with hypertensive emergency including morbidity, mortality, and cost, and the extent to which hypertensive emergency occured among previously diagnosed and treated hypertensives.

background: while less frequent than in the era before effective treatment for hypertension, hypertensive emergency remains a relatively common cause of hospital admission in some sub-populations. in 1989, hypertensive emergency accounted for approximately 60 admissions per year to the medical service at presbyterian hospital, and a somewhat higher proportion of intensive care unit admissions and utilization. the importance of hypertensive emergency may have been underestimated because the international classification of diseases discharge codes included only malignant hypertension, a severe form comprising only about half of the admissions for hypertensive emergency. there had been almost no epidemiologic studies of hypertensive emergency since 1969, and very little was known about risk factors. design narrative: a matched case-control study design was used. cases were obtained from admissions to the medical service at presbyterian hospital. morbidity and mortality data were obtained by follow-up of the case series.

Eligibility criteria:
inclusion criteria 1. patients admitted in the emergency room and for the medical and surgical services at the presbyterian hospital and harlem hospital center in new york city * patients with incidents of hypertensive emergency or hypertensive urgency * hypertensive patients with other acute conditions who were admitted to the hospital or were treated in the emergency room and released exclusion criteria 1. under 21 years of age 2. pregnancy
impact of hyperuricemia on psoriatic arthritis

Conditions: Psoriatic Arthritis

Summary: psoriatic arthritis and gout (linked to hyperuricemia) are two rheumatisms well known to rheumatologists. there are epidemiological and physiopathological arguments in favor of a non-fortuitous link between these two rheumatisms, which to date has not been established. there is currently no recommendation to treat hyperuricaemia without an episode of gout attack. we hypothesize that there is a link between hyperuricemia and severity of rheumatism. this would ultimately modify the therapeutic management of hyperuricemic patients followed for psoriatic arthritis.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years old) * subject with a history of psoriatic arthritis objectified according to the cim 10-1 coding for patients followed in hospitalization at the hus and hcc * subject presenting psoriatic arthritis objectified during a consultation by an hcc rheumatologist * among these two populations, all subjects for whom at least one serum uric acid assay was available in the medical file * subject having not expressed, after being informed, opposition to the reuse of their data for research purposes exclusion criteria: * subject who expressed their opposition to participating in the study * subject who met the inclusion criteria but whose analysis of the medical file (anamnestic, clinical, biological and radiological data) led to a diagnostic reversal and therefore did not present with psoriatic arthritis * subject under guardianship or curatorship * subject under safeguard of justice

Keywords: psoriatic arthritis hyperuricemia rheumatisms