Kornimate/medical-research-clean huggingface dataset:
consistency of automated neuropsychological assessment metrics (anam) performance in those with deployment acquired mild traumatic brain injury (tbi)

Conditions: Mild Traumatic Brain Injury; Post-Concussive Symptoms

Summary: the purpose of this project is to explore the degree to which performance consistency on neuropsychological measures varies in a sample of operation iraqi freedom (oif)/operation enduring freedom (oef) veterans with a history of mild traumatic brain injury (mtbi) with persistent self-reported symptoms.

mild tbi outcome studies are traditionally limited to single administration or baseline/post-injury assessment models and they often fail to show enduring deficits among persons complaining of such problems. it may be the case that our standard approach to deficit measurement in mtbi has confounded our ability to elicit the actual impairment. the proposed study could generate an assessment paradigm shift (performance over time) and afford professionals the direction to better assess and ultimately serve persons with mtbi. additionally, research on the impact of ptsd symptoms on throughput and cognitive performance has been mixed (bremner et al., 1995; brenner et al, 2010; vasterling et al., 1998, 2002, 2006) and the proposed study will yield additional data in that area.

Eligibility criteria:
inclusion criteria: * between the ages of 18-45 years old * at least one oef/oif deployment * currently receiving physical and/or mental health care through the va eastern colorado health care system * for tbi group - veteran must have a history of at least one deployment- related mild tbi with persistent symptoms exclusion criteria: * effortful performance on the test of memory malingering (tomm) * history of other significant neurological disease (other than mild tbi for the appropriate group) as assessed by interview and chart review * history or diagnosis of deployment-related moderate or severe tbi or mild tbi without persistent symptoms for the tbi groups, or any history of deployment-related tbi for the non-tbi group, as assessed by interview and chart review * history or diagnosis of non-deployment-related tbi * diagnosis of schizophrenia or bipolar mood disorderi disorder as assessed by interview and/or chart review. * problematic drinking behavior that consistently exceeds recommended drinking limits per day, e.g., diagnosis of alcohol abuse disorder or alcohol dependence disorder per the mini; or five or more alcoholic drinks per day, four out of seven days per week for the previous two weeks or during the assessment process * use of illicit substance(s) more than five times in the two weeks before enrollment or during the testing process. * inability to read the informed consent document or adequately respond to questions regarding the informed consent procedure

Keywords: deployment acquired mild traumatic brain injury persistent post-concussive symptoms repeated measures
the effectiveness of mindfulness-based intervention as a workplace health promotion program on weight loss

Conditions: Mindfulness; Weight Loss; Workplace; Health Promotion

Summary: the present study will carry out a workplace health promotion via mbi with lessons of dietary behavior to help overweight or obese workers to loss weight.

the study will adopt a longitudinal research design with randomized quasi- experimental trial. the workers with overweight or obesity (bmi≧24) provided by the company will be randomly assigned to group a (four lessons of dietary behavior and six lessons of mbi) or group b (four lessons of dietary behavior and six lessons of mental health). there will be 100 participants in each group. data will be collected five times. the research questionnaire includes basic information (including bmi, waist circumference, etc), perceived stress scale, the five facet mindfulness questionnaire, food cravings questionnaire, the scale of physical activity and information regarding dietary behavior.

Eligibility criteria:
inclusion criteria: 1. adults aged 20 to 65 years old; 2. full-time workers with bmi ≧ 24; 3. motivated to participate in the study; exclusion criteria: 1. suffering from mental illness or in an acute episode; 2. suffering from life threatening or other major physical illness; 3. no motivation to participate in the study.

Keywords: mindfulness-based intervention weight loss workplace health promotion obesity
endoscopic perfusion utilizing icg fluorescence technology

Conditions: Quality of Life

Summary: the main objective of the study is to evaluate the efficacy of indocyanine green (icg) endoscopy to evaluate tissue perfusion during endoscopic neurosurgery. this includes patients with pituitary and intracranial tumors and treatment of vascular abnormalities such as aneurysms and compressive syndromes. icg will be evaluated to determine the value of the additional visual information supplied during the treatment of these pathologies.

over the past decade, a technique widely used by ophthalmologists to assess retinal blood flow, near-infrared icg angiography, has been applied to neurosurgical patients undergoing a wide variety of cerebrovascular procedures. this technique offers the advantage of real-time visualization of cerebral blood flow through the operating microscope at the time the procedure is being performed. indocyanine green is an ideal agent for imaging vessels as it is tightly bound to plasma albumin, has a short half-life, and maintains an acceptable safety profile. furthermore, the excitation and emission profiles for icg lie in the near-infrared wavelengths, which allow penetration and imaging of vessels below a few millimeters of tissue. patients with either an aneurysm, compressive syndromes or pituitary and intracranial tumor will be enrolled in the study. by taking advantage of the natural fluorescence of indocyanine green (icg) within the red spectrum and applying a light filter to the endoscope eyepiece and camera it will show as to whether this technique provides adequate visual information to differentiate perfusion in tumor and surrounding structures and to evaluate normal vessels for aneurysm and compressive syndromes procedures.

Eligibility criteria:
inclusion criteria: * patient population would include those patients with pituitary tumors, intracranial tumors, aneurysms, and normal tissue adjacent to tumors to clarify normal from abnormal. also, patients with compressive syndromes to ensure patency of normal vessels. this would be all patients undergoing endoscopic surgery, both endonasal and open (retromastoid or transcranial). exclusion criteria: * less than 18 years of age * iodine allergy * shellfish allergy * contrast allergy * previous anaphylactic reaction to icg * pregnant * anyone with any evidence of renal or hepatic dysfunction

Keywords: icg dye endoscopic neurosurgery tissue perfusion
the influence of a stabilization splint on the body posture

Conditions: Temporomandibular Disorders; Craniomandibular Disorders; Arthromyalgia; Chronic Disease; Occlusal Appliance

Summary: the study was designed to investigate a possible influence of an occlusal stabilization splint on the body posture in tmd cases and controls. interocclusal appliances or occlusal splints are therapeutic devices that are most frequently used in the treatment of tmd. changes of the mandibular position and occlusal equilibrations are assumed to have an impact on the general body posture.

thirty tmd cases and 10 controls were included in the study. all participants were recruited from the school of dentistry, university of greifswald. all subjects gave their written consent to participate in the study. they then completed a tmd history questionnaire and underwent a clinical examination. the examination included palpation of the masticatory muscles and the tmjs, range of mandibular motion measurements, and assessment of joint noises. the tmd cases were required to have a diagnoses of myofascial pain and/or arthralgia. controls had to be free of pain symptoms in their masticatory muscles and tmjs. body posture was measured during five minutes of walking using an ultrasound-distance measuring device (sonosens® monitor) with small sensors placed on the skin that continually record changes in the distance between them. a static posture evaluation was performed with a contactless, and radiation-free static measurement of the back surface and spine using a 3d measurement system (formetric ii). a second measurement was performed after insertion of the occlusal appliance and a third one after 7 days of treatment. the occlusal appliances were inserted after the first examination and all participants were instructed to use it at night and during examinations.

Eligibility criteria:
inclusion criteria: * tmd cases: diagnoses of myofascial pain and/or arthralgia exclusion criteria: * tmd cases: chronic systemic diseases, cardiac pacemakers

Keywords: temporomandibular disorder craniomandibular disorder occlusal appliance clinical trial
anxiety-related fixation instability during lasik

Conditions: Refractive Errors

Summary: anxiety is common among patients undergoing eye surgery, which is typically performed under topical anesthesia while the patient is awake. this can be an unsettling experience for patients, who may worry about being able to keep their eyes still during surgery, cooperate with the surgical team, and remain immobile in an unfamiliar environment. patients may also experience anxiety due to concerns about surgical pain, possible complications, and the uncertainty of the outcome of the surgery. in this study, the investigators aimed to investigate the correlation between the severity of anxiety symptoms during lasik, and fixation instability during photo-ablation as plotted by the eye tracker.

patient cooperation during lasik is essential for the surgeon's comfort and predictable results. fixation instability, which is the inability of the patient to keep their eye still during surgery, is a common problem during lasik surgery and may lead to unexpected outcomes. eye movements occur continually during the excimer ablation. these eye movements can have a large amplitude, a frequency of over 100 hz, and a corneal speed of around 150 mm/s. with the advancement of scanning-spot excimer lasers, much work has focused on increasing the efficacy of the photo-ablation and smoothness of the ablated surface, especially with respect to the position of the patient's eye by developing state-of-the-art eye trackers to help maintain alignment during photoablation, which can improve refractive outcome.

Eligibility criteria:
inclusion criteria: * candidates undergoing lasik with 1. myopia up to 12 diopters 2. hyperopia up to 6 diopters 3. astigmatism up to 6 diopters exclusion criteria: 1. previous corneal surgery, 2. pregnant or lactating females, 3. concomitant ocular or systemic disease that contraindicated lasik, 4. patients with communication barriers, hypochondria, previous stressful surgical experiences, taking psychotropic drugs, or having a history of any clinically relevant psychiatric or cardiovascular disease.

Keywords: laser in situ keratomileusis anxiety eye-tracker fixation instability
neighborhood alcohol & hiv prevention in south african townships (philani)

Conditions: Fetal Alcohol Syndrome; HIV; Nutrition Disorders

Summary: the purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with mothers in south africa, most of whom are at risk delivering babies with fetal alcohol syndrome, babies that are underweight, or babies that are infected with hiv from an hiv-positive mother. the investigators hypothesize that the intervention will reduce the chance of these three health outcomes occurring in the babies and improve the health of the mother.

there are four intersecting epidemics among pregnant women in south africa: hazardous alcohol use (30%), hiv (27%), tb (60% of hiv+), and malnutrition (24% of infants). unless the prevention programs for these epidemics are horizontally integrated, there will never be adequate resources to address these challenges and stigma will dramatically reduce program utilization. furthermore, while clinics are the typical sites for treating each of these health problems, this proposal will examine a home-visiting prevention program delivered by neighborhood mentor mothers (mm) as an alternative to clinic-based interventions to reduce the consequences of hazardous alcohol use, hiv, tb, and poor nutrition. the intervention will encourage mothers to care for their own health, parent well, maintain their mental health, and, if the mother is living with hiv (hiv+ mar), reduce hiv transmission and/or reduce alcohol use and abuse. the results begin to inform the optimal delivery strategy for next generation of preventive interventions in order to be feasible and sustainable for broad dissemination immediately following an efficacy trial.

Eligibility criteria:
inclusion criteria: * pregnant woman and their children * age 18 or older * informed consent exclusion criteria: * psychosis, neurological damage, inability to communicate with interviewer * inability to give consent

Keywords: fetal alcohol syndrome alcohol abuse hiv malnutrition children mentor mother behavioral intervention south africa maternal alcohol use hiv-related transmission behaviors low birth weight babies and low-weight children hiv seronegativity
accuracy of doppler ultrasound versus manual palpation of pulse in cardiac arrest

Conditions: Cardiac Arrest

Summary: the flopatch fp120 device is indicated for use for the noninvasive assessment of blood flow in the carotid artery. the flopatch fp120 device uses ultrasound and the doppler effect to non-invasively assess the flow of flood. in this study, the flopatch fp120 will be applied to the neck at the location of the carotid artery on cardiac arrest patients in the emergency department. flopatch fp120 data will be compared with arterial line blood pressure to assess for accuracy of pulse checks among cardiac arrest patients in the emergency department.

the flopatch fp120 device is indicated for use for the noninvasive assessment of blood flow in the carotid artery. the flopatch fp120 device uses ultrasound and the doppler effect to non-invasively assess the flow of flood. in this study, the flopatch fp120 will be applied to the neck at the location of the carotid artery on cardiac arrest patients in the emergency department. this study will determine the peak systolic velocity, as measured by the flopatch fp120 device, that is associated with a systolic blood pressure of ≥60 mmhg on a femoral arterial line in cardiac arrest patients during a pulse check. the associated accuracy, sensitivity, and specificity of the calculated pulse systolic velocity to detect return of spontaneous circulation with a systolic blood pressure ≥60 mmhg in cardiac arrest.

Eligibility criteria:
inclusion criteria: * 18+ years of age * in cardiac arrest at the north shore university hospital emergency department * arterial line placed during cardiac arrest resuscitation exclusion criteria: * traumatic cardiac arrest * patients without bilateral lower extremities
impact of tecar therapy on pain and function in adhesive capsulitis:

Conditions: Adhesive Capsulitis

Summary: transfer energy capacitive and resistive (tecar) therapy is a heat therapy method that increases blood circulation at the microscopic level by generating heat in the upper and lower layers of your tissues, reduces inflammation and supports tissue regeneration. in this study, we aimed to evaluate whether this treatment reduces pain and improves functioning in patients with frozen shoulder disease.

adhesive capsulitis (ac), commonly known as "frozen shoulder," is a prevalent and painful condition resulting from the contracture of the glenohumeral capsule, which significantly impacts individuals' quality of life. while ac is self-limiting in many cases, some patients may experience long-term functional limitations if not treated promptly. one promising intervention is transfer energy capacitive and resistive (tecar) therapy, which has gained attention for its potential to enhance tissue regeneration, reduce inflammation, and improve pain management by generating heat in superficial and deep tissues. this study aimed to evaluate the effects of tecar therapy on pain and functional outcomes in patients with adhesive capsulitis (ac). this prospective, randomized controlled clinical trial included 60 patients \[tecar group: 30, (50.37 ± 13.90 years); control group: 30, (55.27 ± 10.44 years)\]. both groups completed a 2-week tailored therapeutic exercise program, with 30-minute hot pack application and transcutaneous electrical nerve stimulation. the tecar group also received three tecar therapy sessions per week, for a total of six sessions. pain was measured using the visual analog scale (vas), functional status with the shoulder pain and disability index (spadi), and supraspinatus tendon thickness and bicipital effusion were assessed via ultrasonography. evaluations were conducted at baseline, 1 and 3 months post-treatment.

Eligibility criteria:
inclusion criteria: * patients who were than 18 years of age * patients with unilateral shoulder pain of at least 3 on a 10-point visual analog scale (vas); * patients who experienced a more than 50% loss of passive rom (abduction or external rotation) in the glenohumeral joint relative to the unaffected side * patients who had been experiencing the related symptoms for ≥ 3 months. exclusion criteria: * patients who had previous shoulder surgery * patients who had shoulder injection within the last 3 months * patients with inflammatory rheumatic disease, * patients with cervical radiculopathy * pregnant patients * pateints with thyroid disease * patients with malignancy, * patients who had history of cardiac pacemakers, * patients with epilepsy * patients who had neurological disease with or without cognitive impairment

Keywords: adhesive capsulitis pain management tecar therapy vas
the model building and empirical research of eye health interventions for children

Conditions: Myopia

Summary: the purpose of this study is to determine whether eye health intervention can obviously reduce and delay myopia onset and development and improved the awareness rate of knowledge apparently .


Eligibility criteria:
inclusion criteria: * primary 1-3 grade students exclusion criteria: * ocular inflammation * eye injury * dysgnosia

Keywords: myopia
complementary and alternative medicine in patients with inflammatory bowel disease. a cross sectional study in norway.

Conditions: Inflammatory Bowel Diseases

Summary: the purpose of this study is to investigate the proportion of use of complementary and alternative medicine (cam) in patients with inflammatory bowel disease (ibd). in addition, the reason for, and satisfaction with use of cam.


Eligibility criteria:
inclusion criteria: * patients \>18 years and with verified diagnosis of crohn's disease or ulcerative colitis attending an outpatient clinic in a norwegian hospital. exclusion criteria: * patients \<18 years.

Keywords: complementary and alternative medicine hrqol, inflammatory bowel disease
can levothyroxine treatment reduce the development of cardio-metabolic disorder in subclinical hypothyroidism?

Conditions: Subclinical hypothyroïdism

Summary: 2. aim/ objectives the aim of this study is to evaluate the clinical, laboratory and echocardiographic findings in children with sch. to investigate the effect of replacement therapy with levothyroxine on cardiovascular risk factors in children with sch.

sub-clinical hypothyroidism (sch) is a form of thyroid dysfunction in which the thyroid-stimulating hormone (tsh) level is high, while serum total/free thyroxine (t4/ft4) is within the normal reference range . sch is mostly detected accidentally as most of the patients manifest few or no signs of thyroid dysfunction. the most common causative factor for sch is chronic autoimmune thyroiditis characterized by high titers of thyroid peroxidase antibodies, thyroglobulin antibodies and rarely tsh receptor blocking antibodies. however, mutations in several proteins involving in tsh action including tsh receptor gene and mutations of dual oxidase 2 (duox2), phosphodiesterase 8b and thyroid peroxidase have also been demonstrated as causes of tsh elevation . sch might be associated with endothelial dysfunction due to early changes in proatherogenic profiles as there is elevation in plasma levels of total cholesterol (tc) and low-density lipoprotein-cholesterol (ldl-c) in sch patients , also there is increased risk of hypertension in sch patients than in euthyroid . many studies found that homocysteine concentration appears to be increased in hypothyroidism and decreased in hyperthyroidism, and there is relationship between hyperhomocysteinemia and cardiovascular disease, including increased platelet aggregation, increased coagulation or reduced thrombolysis and endothelial dysfunction . the acute-phase reactant hs-crp is known to be a sensitive and non-specific marker for inflammation, tissue damage and infection . serum hs-crp measurements are used to determine cardiovascular risk. hs-crp is regarded as a predictive marker for myocardial infarction, stroke, peripheral artery disease and sudden cardiac death . the treatment of children with sch is controversial; and there is not enough evidence that treatment can prevent the risk of developing cardiovascular and metabolic disorders in sch.

Eligibility criteria:
inclusion criteria: * 1. patients aged from 5-15 years diagnosed with sh (patients with elevated tsh and normal ft4 on two different measurements 4-6 weeks apart). exclusion criteria: * 1. patients with acute or chronic disorders (anemia, infection, diabetes mellitus, malignancy, liver and renal disorder). 2. patients with a history of medication that affect thyroid function tests as glucocorticoids, dopamine or dobutamine, amiodarone, lithium, interferons, alemtuzumab. 3. patients with bmi\>95 percentile.
early rehabilitation of patients with posttraumatic amnesia

Conditions: Amnesia

Summary: the purpose of this study is to investigate if a systematic intervention with early identifying of patients with posttraumatic amnesia using a reality orientation therapy can reduce the period with posttraumatic amnesia in order to get a better outcome for patients with traumatic brain injury

1. a systematic review with the latest investigation and treatment of patients with posttraumatic amnesia 2. investigate the effect of a systematic nursing programme on the length of posttraumatic amnesia 3. investigate the effect of a systematic nursing programme after 12 month 4. describe perspectives for the future within the early rehabilitation of patients with posttraumatic amnesia

Eligibility criteria:
inclusion criteria: * patients should be able to speak and understand danish * patients with traumatic brain injury * a verified brain injury at the ct scanning exclusion criteria: * patients with medical illness * patients with other neurological illness * patients with neuroinfections meningitic, encephalitic * patients who does not understand and speaks danish

Keywords: posttraumatic amnesia early intervention a systematic nursing programme in the icu early identification of patients with posttraumatic amnesia