Kornimate/medical-research-clean huggingface dataset:
biomarkers of theta burst stimulation in major depressive disorder

Conditions: Depressive Disorder, Treatment-Resistant

Summary: this study investigates the brain-based biomarkers of treatment response to accelerated theta burst stimulation (atbs) in patients with major depressive disorder resistant to pharmacological treatment(mdd) in an open label design.

theta burst stimulation (tbs) is a newer form of rtms which requires less stimulation time and produces longer lasting post-stimulation effects in the cerebral cortex (4). it has been shown to be effective in inducing synaptic plasticity and has similar or better efficacy in treating depression compared to rtms (4).newer accelerated tbs (atbs) protocols that condense stimulation sessions down to several days rather than weeks have shown similar response rates when compared to prolonged tbs protocols, also with similar tolerability and safety. in order to develop atbs as an effective treatment for mdd, future research should focus on identification of reliable predictors for better outcome to tbs. the main objectives were: 1) to directly compare multiple different brain-based measures (neuroimaging and electrophysiology) to identify which has the most power in accurately predicting response to tbs compared to sham. 2) to track both short and long-term longitudinal electrophysiological (eeg) changes related to the therapeutic effects of tbs.

Eligibility criteria:
inclusion criteria: 1. participant must meet the dsm-5 diagnostic criteria for single-episode major depressive disorder (mdd). 2. participant must have failed to respond to \>1 but \<4 classes of oral antidepressant treatments in the current episode of depression. 3. participant must have a hamd total score of at least 18 exclusion criteria: 1. the participant's depressive symptoms have previously demonstrated nonresponse to: * an adequate course of rtms/tbs over dlpfc in the current major depressive episode, defined as at least 3 weeks of treatment, 5 times weekly * an adequate course of treatment with electroconvulsive therapy (ect) in the current major depressive episode, defined as at least 7 treatments with unilateral/bilateral ect. 2. participant has received vagal nerve stimulation (vns) or has received deep brain stimulation (dbs) in the current episode of depression. 3. participant has a current or prior dsm-5 diagnosis of axis i comorbidities, including psychosis, bipolar disorder, obsessive compulsive disorder, based upon clinical assessment and confirmed by the mini. 4. participant has a current or prior dsm-5 diagnosis of axis ii comorbidities, including severe borderline personality disorders, antisocial, schizotypal, schizoid personality disorders based upon clinical assessment and confirmed by the mini. 5. participant has severe suicidal ideation/plan/ intent. 6. participant has a history of moderate or severe substance or alcohol use disorder according to dsm-5 criteria. 7. participant has a current or past history of seizures and neurological problems, e.g. head injury, stroke, progressive neurological disorder and complicated and unstable medical disorders, e.g. cardiovascular-related conditions, diabetes.
effects of trunk stabilization training device on balance ability for stroke patients

Conditions: Stroke

Summary: the purpose of this study is to assess the effectiveness of balance pro(sbt-330:trunk stabilization training device) for stroke patients reduced balance ability

after being informed about the study and potential risks, all patients giving written informed consent will undergo a 1-week screening period to determine eligibility for study entry. subjects who pass the screening test will randomize in a 1:1 ratio to experimental group(conventional rehabilitation + trunk stabilization training device, 30min each, 20days) or control group(conventional rehabilitation + conventional rehabilitation, 30min each, 20days). and then, they receive a registration number within 7 days and proceed with the pre-intervention test.

Eligibility criteria:
inclusion criteria: * stroke patients 40 years or older (within 2 years of onset) * those who have no problems with visual function in conducting and conducting clinical trials * patients who are found to have decreased balance ability after stroke (bbs score is 21-40 points) * those who do not have orthopedic diseases in both lower limbs * subjects with cognitive functions capable of fulfilling and carrying out instructions * those who voluntarily consent to the clinical trial exclusion criteria: * subjects with intellectual disabilities to the extent that they are unable to perform instructions * subjects taking drugs that may affect the study * subjects with skin and musculoskeletal abnormalities for which the device cannot be worn * patients with neurological disorders other than stroke and other disorders that may affect balance * other subjects who are judged to be unsuitable for this study

Keywords: trunk stabilization training
women with migraine with aura neuroimaging study

Conditions: Migraine With Aura

Summary: the purpose of this study is to investigate whether a particular form of migraine, migraine with aura, is associated with structural changes in the brain


Eligibility criteria:
inclusion criteria: * female * case (migraine with aura), co-twin to case, or control (migraine-free) * residency in denmark * no severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders exclusion criteria: * male * residency outside denmark * registered in civil registry as not to be contacted by researchers * severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders * mobile metal parts or other contraindication for mri * weight of 130+ kilograms * pregnancy * subjects that wished not to be informed about abnormal findings on mri * chronic tension-type headache, medication overuse headache, or cluster headache (diagnosed through physician interview) * frequent tension-type headache (control group only, self-reported or diagnosed through physician interview)

Keywords: migraine with aura migraine case-control study magnetic resonance imaging brain diseases
the immediate effects of passive hip joint mobilization on hip muscle strength in patients with anterior knee pain

Conditions: Anterior Knee Pain Syndrome; Patellofemoral Pain Syndrome

Summary: the aim of the study is to assess the immediate effects of passive hip joint mobilisation (in comparison to a sham mobilisation) on eccentric hip abductor/external rotator muscle strength on the basis of manual muscle testing with a hand-held-dynamometer within a double-blinded cross-over study design. patients with anterior knee pain and signs of impaired hip function will be recruited in vienna and surrounding area, measurements/data collection will be conducted by two experienced physiotherapists in a physiotherapy group practice in 1150 vienna.


Eligibility criteria:
inclusion criteria: * diagnosis: anterior knee pain * prescription for physiotherapeutic treatment of anterior knee pain * signs of functional hip impairment: * impaired hip kinematics during single leg squat * reduced passive hip joint mobility in comparison to the other, unaffected side * manually weak tested hip abductors/external rota-tors in comparison to the other, unaffected side exclusion criteria: * intraarticular knee pathology * preceding trauma/operation of lower extremity on affected side * spinal disorders associated with low back pain, lumbar referred pain or nerve root irritation * severe and/or recurring ankle sprains in recent history (significant enough, that it required a period of immobilization) * other relevant comorbidities such as neurologic/rheumatologic/psychiatric diseases, osteoporosis and malign disorders * pregnancy

Keywords: mobilization muscle strength hip abductors hip external rotators
prediction of persistent postsurgical pain after video-assisted thoracic surgery (vats)

Conditions: Pain, Postoperative

Summary: prospective cohort study of factors predisposing to persistent post surgical pain after video-assisted thoracic surgery


Eligibility criteria:
inclusion criteria: * age \< 18 years old * elective lung cancer surgery (vats) exclusion criteria: * do not understand danish * cognitive reduction * bilateral procedure planned * previous thoracic surgery * pregnant or nursing * known nerve affection from other cause * alcohol/substance abuse * inability to cooperate to pain scoring/sensory examination * \> 5 mg methylprednisolone/day

Keywords: vats standardized surgery persistent pain
antiglutamate anticonvulsants in the treatment of alcohol withdrawal syndrome

Conditions: Topiramate; Lamotrigine; Memnatine; Diazepam; Placebo

Summary: the study is aimed to evaluate the efficacy of antiglutamate anticonvulsants (topiramate, lamotrigine, and memantine) in the treatment of alcohol withdrawal syndrome


Eligibility criteria:
inclusion criteria: alcohol dependence alcohol withdrawal syndrome exclusion criteria: drug dependence major psychiatric diagnoses severe somatic illness
memory t-cell infusion to improve immunity after tcr-alpha/beta depleted hematopoietic stem cell transplantation

Conditions: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Immune Deficiency Disease; Bone Marrow Failure Syndromes; Opportunistic Infections; Graft vs Host Disease

Summary: the stud will evaluate whether infusions of cd45ra-depleted lymphocytes from the donor early post-transplant is a safe way to improve immunity to common infections in recipients of tcr-alpha/beta depleted hematopoietic stem cell grafts.

graft-versus-host disease (gvhd) remains the most important direct complication of hematopoietic stem cell transplantation. methods used to prevent gvhd include diverse pharmacologic interventions and ex vivo methods of t-cell depletion, the latter being the most effective ones. historically depletion of t-cells from the graft is associated with increased rate of graft failure, relapse of malignant disease and prolonged immune deficiency. selective depletion of tcr-alpha/beta t-lymphocytes is a new method of hematopoietic stem cell graft manipulation which is thought to conserve important cell populations, e.g. nk cells and gamma/delta t cells within the graft. preliminary results suggest that tcr alpha/beta depletion ensures high engraftment rate, low early mortality and good control of gvhd. the problem of delayed immune reconstitution and life-threatening viral infections remains incompletely resolved. depletion of naive (cd45ra-positive) t-cells was developed as a new method of graft manipulation to prevent gvhd. research data indicate that alloreactivity is associated mainly with naive t-cell fraction. in vitro depletion of cd45ra lowers significantly the alloreactive response while retaining reactivity to pathogens. in the current protocol we plan to test whether relatively low doses of cd45ra-depleted mononuclear cells can be safely infused after tcr-alpha/beta depleted transplantation. the biologic readout for the protocol will be quantitative assessment of t-cell reactivity to common pathogens after infusion.

Eligibility criteria:
inclusion criteria: * recipient of allogeneic hematopoietic stem cell graft from haploidentical or matched unrelated donor * tcr alpha/beta depletion of the hematopoietic stem cell graft * cmv-seropositive donor * stable hematopoietic engraftment exclusion criteria: * active graft-versus-host disease grade 2-4 * any systemic immune suppressive therapy except calcineurin inhibitor monotherapy * uncontrolled sepsis

Keywords: cd45ra-depletion tcr-alpha/beta depletion hematopoietic stem cell transplantation immune reconstitution graft enhancement, immunologic immunocompromized host
a study to evaluate the safety and efficacy of ng101 in adult participants with symptomatic diabetic or idiopathic gastroparesis

Conditions: Diabetic Gastroparesis; Idiopathic Gastroparesis

Summary: the purpose of this study is to assess the safety and efficacy of various dose levels of ng101 compared with placebo in adult participants with gastroparesis during 12 weeks of treatment.

this is a randomized, double-blind, parallel-group , placebo-controlled, multicenter us-based study to evaluate the safety and efficacy of 3 dose levels of ng101 (metopimazine mesylate) compared with placebo in participants with diabetic or idiopathic gastroparesis. the study will enroll approximately 140 participants. following the screening period, there is a 2-week pretreatment period during which participants will complete an electronic daily diary. participants eligible for the clinical study will be randomly assigned (in a 1:1:1:1 ratio) to receive either ng101 5 mg, 10 mg, or 20 mg, or matching placebo during a 12-week treatment period. all participants will be asked to take one capsule 30 minutes before a meal 3 times a day and 30 minutes before bedtime for a total of 4 capsules daily (qid). the total duration of the study for each participant will be approximately 20 weeks.

Eligibility criteria:
inclusion criteria: * adult patients with diabetic or idiopathic gastroparesis * symptoms consistent with gastroparesis (nausea, vomiting, early satiety, post-prandial fullness, and abdominal pain) * documented evidence of no mechanical obstruction * delayed gastric emptying as demonstrated by gastric scintigraphy or breath test exclusion criteria: * uncontrolled diabetes (defined as hgba1c \> 10%) * severe postural symptoms or evidence of unexplained recurrent dizziness * participant has received and tolerated domperidone and showed no notable symptomatic improvement in gastroparesis symptoms * participant has had endoscopic pyloric injections of botulinum toxin within the 6 months prior to the screening visit. * participant engages in daily recreational use of marijuana * prolactin levels \> 2 x uln
efficacy of hyalase hydro-dissection in treatment of carpal tunnel: randomized double blind controlled clinical trial

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome (cts) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve could offer symptoms and clinical improvement

carpal tunnel syndrome (cts) is the most common compression syndrome the upper extremities. its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. it occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. a lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.

Eligibility criteria:
inclusion criteria: * adult patients * complaining of carpal tunnel syndrome of 3 month duration or more * diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study exclusion criteria: * patient refusal * infection at the site of intervention * local anesthetic allergy
optimizing cns dha delivery in elderly adults at risk for dementia

Conditions: Eldery People; Cognitive Decline; Memory Decline; DHA CNS Delivery

Summary: the purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with lpc-dha and tag-dha on cerebrospinal fluid and blood dha levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognitive/memory decline. extant evidence supports our overarching hypothesis that lpc-dha supplementation will be more effective than tag-dha for increasing central (csf) dha levels and improving biomarker profiles in elderly adults. to assess this hypothesis, the following aims are proposed: specific aim 1: to compare the effects of lpc-dha and tag-dha supplementation on peripheral and csf dha levels in elderly adults experiencing early signs of cognitive/memory decline. specific aim 2: to compare the effects of lpc-dha and tag-dha supplementation on neurotrophic and neurodegenerative biomarkers. secondary aim: to investigate whether changes in csf dha levels correlate with changes in objective measures of executive functioning and episodic memory performance.


Eligibility criteria:
inclusion criteria: 1. men and women 62 to 80 years old; 2. presence of subjective cognitive decline using the scd questionnaire, dex and emq, education-adjusted moca score of \&gt;23 \[106,107\]; cvlt cumulative acquisition score \&gt;1.5 sd below the age-adjusted mean, and preservation of independence in functional abilities, as corroborated by an informant providing information on the mcdr \[108\]; 3. no contraindication to a lumbar puncture (e.g., thrombocytopenia, coagulopathy, concomitant use of anticoagulant medications, etc.); 4. fluency in english; 5. ability to comprehend and comply with the research protocol; and 6. provision of written informed consent. exclusion criteria: 1. diagnosis of mci, ad, parkinson's disease, frontotemporal dementia, multi-infarct dementia, significant head trauma, epilepsy, leukoencephalopathy, or other neurological condition; 2. self-reported emotional disorder such as severe depression or other psychiatric condition causing a persisting decline in functional capability; 3. diagnosis of atrial fibrillation, pancreatic, liver, kidney or hematological coagulation disorder; 4. allergy to shellfish or seafood; 5. current or past substance use causing physiological dependence or persisting change in functional capability; 6. concomitant, regular use of medications that might affect outcome measures or adversely interact with the study product including anticoagulant medications; 7. weekly fish consumption \&gt;1 x 3 oz servings and/or use of dha-containing supplements within 3 months prior to screening.
cetic-i (cera traction improves cervical kyphosis -i)

Conditions: Cervical Kyphosis; Cervical Lordosis; Kyphosis

Summary: the study is a prospective, randomized, single-blinded, sham device controlled, parallel treatment grouped, multi-center, exploratory clinical trial to evaluate improvement of cervical lordosis and safety of cgm mb-1701 (spinal warm massage device, ceragem master v6) in subjects with cervical kyphosis and posterior neck pain.

the cervical kyphosis are also commonly referred to as "turtle neck syndrome." it refers to the deformation of the neck bone into an inverted c-shape due to abnormalities or degenerative changes, and it is named to mean that the neck is bent like a turtle. this device, ceragem master v6 (cgm mb-1701), has been certified as a combination of a personal warmer that can be used to relieve muscle pain by applying constant heat to the human body and a medical vibrator of a device that applies physical energy (vibration, shock, pressure, etc.). also, the device got approval for use with intermittent pneumatic compression and electrically-powered orthopedics traction. the primary purpose of this clinical trial is to confirm the temporary cervical lordosis angle improvement (height) in subjects with cervical kyphosis through the combined function of the test device.

Eligibility criteria:
inclusion criteria: 1. adult male and female subjects who have voluntarily decided to participate and agreed in writing after being briefed on the characteristics of this clinical trial and medical device 2. subjects with cervical kyphosis angle between cervical lordosis 20 degrees and cervical kyphosis 5 degrees. 3. bmi betweeen 18.5 and 30 4. chronic neck pain nrs 4 or higher lasting more than 3 months exclusion criteria: 1. secondary spondylosis 2. a tumor of the spine 3. inflammatory spondylitis 4. myelopathy 5. multiple adjacent radiculopathies and others
effects of mcimt vs ct on upper extremity motor function and adls in chronic stroke patients

Conditions: Chronic Stroke

Summary: "cerebral palsy (cp) affects gross motor function variably, with the spastic type notably impacting movement, coordination, and balance. research highlights that spastic cp, characterized by muscle stiffness, can severely hinder activities like walking and running.

interventions such as gait training and vibrational therapy have shown promise in enhancing muscle function and body movements. a new device, ekko, uses vibrational waves based on neurotransmission cognitive theory to improve gross motor skills in children with cp by applying mechanical vibrations to nerve points. this study aims to compare the efficacy of ekko therapy with traditional conservative treatments (such as range of motion exercises and balance training) in improving gross motor function in children with cp. conducted over six months with randomized controlled trials, the research seeks to provide evidence-based insights into optimizing rehabilitation strategies for better motor performance and quality of life for cp patients.

Eligibility criteria:
inclusion criteria: * participants will be under the age of 40-75 years * diagnosis: stroke exclusion criteria: * patients suffering from motor dysfunction due to other diseases (e.g., cerebral palsy, traumatic brain injury, and parkinson's disease * balance problem * rheumatic diseases * high spasticity