Kornimate/medical-research-clean huggingface dataset:
premium monovision versus other types of monovision and bilateral trifocal implantation.

Conditions: Presbyopia; Refractive Errors; Cataract

Summary: primary objective of this study was to compare the efficacy of premium monovision with restor and panoptix, against other prevalent monovision techniques and against bilateral panoptix implantation in a sample of patients following lens-extraction surgery.

four study groups were formed according to the procedure and the intraocular lens technology that was used: a) monovision group (mog), b) multifocal lens group (mfg), c) hybrid monovision group (hmg), and, d) premium monovision group (pmg). patients who have undergone one of the above categories of presbyopia correction surgery were selected to compare the effectiveness of these techniques by evaluating the uncorrected near, intermediate and distant visual acuity as well as the degree of subjective patient satisfaction, contrast sensitivity, dysphotopsia symptoms and spectacle independence .

Eligibility criteria:
inclusion criteria: * diagnosis of senile cataract with stage 2 nuclear opalescence according to the lens opacities classification system iii (locs-3) grading scale exclusion criteria: * manifest astigmatism \> 1.00 diopters * reports of headaches and/or eyestrain associated with visual activities * positive, pathologic ocular cover test (near \& distant) and / or the mallett's disparity test (near \& distant) and the double maddox rod test * endothelial cell count less than 1900/mm2 * glaucoma * intraocular pressure-lowering medications * former incisional surgery * former diagnosis of corneal disease * former diagnosis of fundus disease * diabetes * autoimmune diseases * mental diseases

Keywords: pseudophakic presbyopic correction premium monovision myopic monovision multifocal intraocular lenses hybrid monovision
a study on the effectiveness evaluation in stroke patients using lower limb assistive walking devices

Conditions: Stroke

Summary: the main purpose of this clinical trial is to evaluate the effectiveness and safety of the mi-r1 walking machine in lower limb motor function training for stroke patients. the main question is to answer: 1. are patients using mi-r1 lower limb walking machine training more effective than those using traditional rehabilitation training? 2. is the mi-r1 lower limb walking machine safe? participants will: 1. the experimental group received mi-r1 lower limb walking machine assisted training, while the control group received traditional rehabilitation training. 2. perform functional testing on the 0th, 14th, and 28th day of training. 3. observe whether there is any discomfort or safety during the rehabilitation training process.


Eligibility criteria:
inclusion criteria: * patients diagnosed with stroke through ct or mri, and only accompanied by hemiplegia on one side, with first-time onset or previous episodes without residual neurological dysfunction; * vital signs stable, neurological symptoms no longer aggravate after 48 hours, no severe cognitive impairment or aphasia, and cooperate with training; * modified ashworth score for lower limb ≤ level 2, standing balance function level ≥1; * voluntarily participating in this trial, understanding and cooperating with the entire trial process, and signing a written informed consent form. exclusion criteria: * bone, joint, muscle disease, or lower limb disabilities (such as severe osteoporosis, fractures, spinal instability, severely limited joint range of motion, severe limb muscle contractures, deformities, etc.) or diseases that affect balance and walking; * stroke caused by cerebellar brainstem injury and cortical injury; * patients with severe primary diseases such as cardiovascular, pulmonary, hepatic, renal, and hematopoietic systems, as well as critically ill and psychiatric patients; * other contraindications or complications that may affect walking training treatment; * patients with local skin damage or pressure ulcers in the lower limbs; * patients with peripheral nerve injury in the lower limbs; * inappropriate body shape for robots (height\ 190cm, or weight\>85 kg); * planned pregnancy or pregnant and lactating women; * participants in other clinical trials within the past 3 months; * severe cognitive impairment; * known refusal or inability to comply with protocol requirements for any reason (including planned clinical visits and examinations); * the researchers believe that it should not participate in this clinical trial.

Keywords: stroke lower extremity walking
ho-1/creb3 modulates golgi stress in patients with sepsis

Conditions: Sepsis

Summary: this study was an ambispective observational cohort study that included sepsis patients hospitalized in the intensive care unit (icu) of the nankai hospital. all patients met the consensus criteria of sepsis-3. the purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

all patients met the consensus criteria of sepsis-3. the purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Eligibility criteria:
inclusion criteria: 1. males or females over the age of 18; 2. sepsis was diagnosed within 48h which meets spesis 3 criteria; 3. capable of understanding the purpose and risk of the study; 4. patients or proxy must give written informed consent before any assessment is performed. exclusion criteria: 1. pregnancy, lactation or perinatal period; 2. breast carcinoma; 3. hiv seropositive or syphilis seropositive; 4. any clinical-relevant condition that might affect study participation and/or study results; 5. participation in any other intervention trial; 6. unwillingness or inability to following the study protocol in the investigators opinion.
evaluation of the efficacy of different strategies to treat anemia in mexican children

Conditions: Anemia

Summary: anemia continues to be a major public health problem in many regions of the world and it is still not clear which strategy is more effective in children population in terms of adherence and efficacy. the objective was to evaluate the efficacy and acceptance of several strategies that have been recently recommended to treat anemia on anemic children (6 to 43 mo):iron supplement, iron+folic acid supplement, a multiple micronutrients supplement a micronutrient fortified complementary food in the form of porridge powder or zinc+iron+ascorbic acid fortified water.


Eligibility criteria:
inclusion criteria: * hemoglobin less than 11.7g/dl and above 7.0g/dl exclusion criteria: * breastfeeding * chronic gastroenteritis * any other severe illness

Keywords: anemia iron children micronutrients
behavioral activation and hiv risk reduction for men who have sex with men with crystal meth abuse

Conditions: Crystal Methamphetamine Abuse; Crystal Methamphetamine Dependence

Summary: the purpose of this study is to research a new behavioral treatment to reduce sexual risk-taking in men who have sex with men (msm) who abuse crystal methamphetamine (crystal meth), and are at risk for hiv acquisition. this study proposes using a treatment based on our original pilot study that incorporates risk reduction and behavioral activation therapy. in order to help learn what types of treatment programs best help individuals who abuse crystal meth and engage in sexual risk-taking, we will compare our treatment to a control group. the treatment group will receive therapy incorporating behavioral risk reduction counseling with behavioral activation therapy to treat depression, helping individuals reengage in their life. the control group will receive the risk reduction counseling without the behavioral activation therapy. the current study hopes to explore the efficacy of this previous developed treatment in a two-arm pilot randomized controlled trial.

1. to estimate, in a two-arm pilot randomized controlled trial (rct), the effect size of the proposed intervention on reductions in sexual risk taking and crystal meth use. the primary outcome is the number of unprotected anal sex acts and a secondary outcome is reduction in crystal meth use episodes over the follow up period. 2. to explore the degree to which improvements in sexual risk taking are associated with the conceptual mediators of the effects of the intervention: reductions in crystal meth use and increases in pleasurable (but safe) activities, bat skills, use of risk reduction skills, and reductions in depressed mood.

Eligibility criteria:
inclusion criteria: * age: 18 years or older * self-reports as a man who has sex with men * hiv-uninfected and verifies serostatus at baseline (hiv antibody testing and positive tests will be confirmed by western blots; see human subjects for operational aspects) * meets dsm-iv diagnostic criteria for crystal meth abuse/dependence * self reported unprotected anal intercourse-receptive or insertive-with a non-monogamous male sexual partner, while concurrently using crystal meth (use of meth must be a few hours prior to, or during, sex) in the prior three months exclusion criteria: * unable to provide informed consent due to severe mental or physical illness, or substance intoxication at the time of interview * has lived in the greater boston area for three months or less (as a means to enhance participant retention) * discovery of active suicidal ideation at the time of interview (these patients will be referred immediately for treatment, but may join the study when this is resolved)

Keywords: crystal methamphetamine abuse crystal methamphetamine dependence sexual risk behavior men who have sex with men (msm) behavioral activation
systems saving lives - long-term survival of out-of-hospital cardiac arrest in the urban area of bologna

Conditions: Cardiac Arrest

Summary: evaluation of clinical, logistical, and technical factors (e.g. implementation of pre-arrival instructions, implementation of the dae responder, mechanical chest compressor, reboa, and e-cpr) that impact on the outcomes of out-of-hospital cardiac arrest patients.


Eligibility criteria:
inclusion criteria: * out of hospital cardiac arrest patients (historical cohort) from 1st january 2009 and 30th june 2020 * out of hospital cardiac arrest patients from 1st july 2020 and 31st december 2025 exclusion criteria: * false cardiac arrest * in-hospital cardiac arrest
a study to investigate the effect of hepatic impairment on the pharmacokinetics, safety, and tolerability of azd2389

Conditions: Hepatic Impairment

Summary: the purpose of this study is to examine the safety and tolerability of azd2389 in participants with hepatic impairment and participants with normal hepatic function.

this is a single-dose, non-randomised, open-label, parallel-group study to examine the pk, fibroblast activation protein activity, safety, and tolerability of azd2389 in participants with hepatic impairment and participants with normal hepatic function. the study is planned to consist of: * cohort 1: participants with normal hepatic function (sex-, age-, and body mass index \[bmi\]-matched) * cohort 2: participants with mild hepatic impairment (cp a classification) * cohort 3: participants with moderate hepatic impairment (cp b classification) * cohort 4 (optional): participants with severe hepatic impairment (cp c classification) safety, tolerability, and available plasma pk data up to 48 hours post-dose from at least 4 participants in each of the mild hepatic impairment (cp class a) and moderate hepatic impairment (cp class b) cohorts must have been assessed by the investigator(s), medical monitor, and sponsor prior to the decision to proceed with evaluation/recruitment of participants with severe hepatic impairment (cp class c). cohort 1 (normal hepatic function) will be initiated in parallel with cohorts 2 and 3.

Eligibility criteria:
inclusion criteria: for hepatic: * participant with a diagnosis of stable hepatic impairment for healthy: * participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, and laboratory tests. all participants: - body weight ≥ 50 kg; bmi within the range of 18.0 to 42.0 kg/m2 (inclusive). exclusion criteria: * participant has egfr \< 60 ml/minute/1.73 m2 * positive test for hiv at screening * history of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity * history of severe dermatological disorders

Keywords: mild moderate severe matched healthy controls liver fibrosis liver cirrhosis
assessing efficacy of intravenous acetaminophen for perioperative pain control for oocyte retrieval

Conditions: Infertility, Female; Pain, Postoperative

Summary: in this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge from the hospital. we will compare three types of pre-operative medications: intravenous (iv) acetaminophen, oral (po) acetaminophen, and placebo (no medication), which is the current typical care.

objective: to compare the efficacy of pre-operative iv acetaminophen, po acetaminophen, versus placebo for adjunctive pain control in the setting of oocyte retrieval in an in vitro fertilization clinic setting. hypothesis: our hypothesis is that patients receiving iv acetaminophen pre-operatively will have improved postoperative pain scores, lower overall opiate consumption, and shortened time to discharge from post analgesic recovery unit (pacu) or recovery than those receiving po acetaminophen or placebo. participants will be consented and enrolled in the study prior to their oocyte retrieval. the patient will then be randomized to one of three treatments: group 1: in the pre-op suite, these patients will receive 1000mg iv acetaminophen and po placebo, followed by standard protocol anesthesia and pain control as needed. group 2: in the pre-op suite, these patients will receive 1000mg po acetaminophen and iv placebo, followed by standard protocol anesthesia and pain control as needed. group 3: in the pre-op suite, these patients will receive po and iv placebo, followed by standard protocol anesthesia and pain control as needed. the patient and care team will be blinded to the treatment group. a member of the study staff will review participants' medical record to collect data regarding demographics, clinical history, cycle and pregnancy outcomes, up to 12 months following study completion.

Eligibility criteria:
inclusion criteria: \[ \] patient is 18 years or over, undergoing oocyte retrieval. \[ \] patient is english-speaking. exclusion criteria: \[ \] allergy/hypersensitivity to acetaminophen or opiates. \[ \] any history of liver disease, history of alcohol depending, or renal impairment as reported in the electronic health record. \[ \] any history chronic opiate use or chronic pain disorder reported in the electronic health record. \[ \] weight less than 50kg as reported in the medical record.

Keywords: in vitro fertilization oocyte retrieval acetaminophen postoperative pain control
effects of intraoperative gdft on the postoperative brain edema

Conditions: Fluid Therapy; Brain Edema; Brain Tumor

Summary: whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. to our knowledge, there has been no extensive and quantitative analysis of brain edema following svv-based gdft in neurosurgical patients with malignant supratentorial glioma. so the study aims to observe the effect of the stroke volume variation-based gdft on the postoperative brain edema and decrease the incidence of postoperative complications in neurosurgical patients with malignant supratentorial gliomas.


Eligibility criteria:
inclusion criteria: 1. preoperative brain image indicating high-grade glioma (hgg), verified by postoperative histology of the world health organization (who) as grade iii or iv tumors. 2. age 18-65 years, and american society of anaesthesiologists (asa) physical status i to iii. 3. signed informed consent. exclusion criteria: 1. renal insufficiency or the creatinine clearance is \< 30 ml/kg. 2. heart disease, new york heart association functional classification (nyha) class ii or higher heart failure, or if their cardiac ejection fraction is \< 20%. 3. chronic obstructive pulmonary disease. 4. extensive peripheral arterial occlusive disease. 5. coagulopathy. 6. surgery in the prone position. 7. recurrent carcinoma or tumor in the brain ventricular. 8. body mass index \ 30.0 kg·m-2. 9. awake craniotomy.
effect of low-dose intracoronary reteplase on myocardial infarct size during primary percutaneous coronary intervention

Conditions: Acute ST-segment Elevation Myocardial Infarction

Summary: objective: to determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with reteplase infused after coronary reperfusion will reduce the myocardial infarction size. design, setting, and participants: 306 patients presenting at 15 hospitals in china within 12 hours of acute st-segment elevation myocardial infarction (stemi) due to a proximal-mid-vessel occlusion of left anterior descending (lad) coronary artery occlusion will be randomized in a 1:1:1 dose-ranging trial design. patients will be followed up to 1 month. interventions: participants will be randomly assigned to treatment with placebo (n = 102), reteplase 9mg (n = 102), or reteplase 18mg (n = 102) by manual infusion over 2 minutes after reperfusion of the infarct-related coronary artery and before stent implant. main outcomes and measures the primary outcomewas the myocardial infarct size (% left ventricular mass) demonstrated by contrast-enhanced cardiac magnetic resonance imaging (mri) conducted from days 2 through 7 after enrollment.


Eligibility criteria:
inclusion criteria: 1. acute stemi with persistent st-segment elevation or recent left bundle-branch block with a symptom onset to reperfusion time of 12 hours or less. 2. angiographic criteria included a proximal-mid coronary artery occlusion (timi coronary flow grade 0 or 1) or, impaired coronary flow (timi flow grade 2, slow but complete filling) in the presence of definite angiographic evidence of large thrombus (timi grade ≥2) in left anterior descending (lad) coronary artery. exclusion criteria: 1. rescue pci after thrombolytic therapy. 2. need for emergency coronary artery bypass grafting. 3. presence of cardiogenic shock. 4. life expectancy of \< 6 months. 5. inability to provide informed consent. 6. contraindications for the use of thrombolysis, including active internal bleeding, history of intracranial haemorrhage or ischaemic stroke within 6 months, recent major surgery or trauma, severe uncontrolled hypertension, thrombocytopenia and severe liver or kidney failure.
du and boo in women with and without symptoms of vd

Conditions: Detrusor Underactivity; Bladder Outlet Obstruction

Summary: women with symptoms of voiding dysfunction may be associated with detrusor underactivity or bladder outlet obstruction. however, the prevalence of detrusor underactivity and bladder outlet obstruction remained obscure. thus, the aim of this study was to elucidate the prevalence of detrusor underactivity and bladder outlet obstruction in women with and without symptoms of voiding dysfunction.

between february 2005 and december 2020, all women with lower urinary tract symptoms but without cystocele who visited the urogynecological department of a medical center for urodynamic evaluation were reviewed. those women who have no complete data of maximum flow rate, voided volume, post-void residual volume and detrusor pressure at maximum flow rate were excluded from this study. detrusor underactivity was defined when the detrusor pressure at maximum flow rate was less than 20 cmh2o, the maximum flow rate was less than 15 ml/s, and the bladder voiding efficiency was less than 90 %. bladder outlet obstruction was defined when the the detrusor pressure at maximum flow rate was not less than 40 cmh2o, and the maximum flow rate was less than 12 ml/s. those women without detrusor interactivity or bladder outlet obstruction were allocated to the non-du/boo group. stata software was used for statistical analysis. chi2 test, univariate and multivariable logistic regression test were used for statistical analysis as appropriate. a p \< 0.05 was considered as statistically significant.

Eligibility criteria:
inclusion criteria: * women with lower urinary tract symptoms * complete urodynamic study exclusion criteria: * advanced cystocele * after surgery for cystocele repair * chronic infection * incomplete data

Keywords: detrusor underactivity bladder outlet obstruction voiding dysfunction
the effects of preoperative and postoperative oral nutritional supplements in malnourished post-gastrectomy patients

Conditions: Malnourished; Stomach Neoplasms; Gastrointestinal Stromal Tumors

Summary: the objective of this study is to evaluate the effect of a perioperative nutrition strategy using oral nutritional supplements (ons) on postoperative complications and improvement in body weight in malnourished patients who underwent gastrectomy.


Eligibility criteria:
inclusion criteria: * patients older than 20 years * patients who undergo distal, total, proximal, or pylorus-preserving gastrectomy * patients who are assessed as moderate or severe malnourished according to pg-sga or patients with bmi lower than 18.5 kg/m2 * patients who can take oral meals * patients who agree on the informed consent exclusion criteria: * emergent operation * patients who received preoperative chemotherapy or radiation therapy within 6 months * pregnant patients * patients who cannot consume the ensure powder * patients who enrolled another clinical trials
non-powered negative pressure wound therapy vs open technique for pilonidal disease

Conditions: Pilonidal Disease; Pilonidal Sinus

Summary: pilonidal disease is disease of young patients with significant morbidity and is difficult to treat. currently multiple methods are practiced for the treatment of the disease, two of them are preferred over others and practice extensively. first one involves excision of pilonidal sinus and dressings while the second one is excision of the pilonidal sinus with application of negative pressure wound therapy. none of these approaches is considered superior to the other, as not enough comparison studies of the two procedures have been done. in order to clarify this and find the best option for our patients, investigators are taking opportunity to compare these two modalities. if participants choose to participate in this study they will be randomly selected to one of these groups and the progress of wound healing will be monitored after surgery with the measurement of wound weekly and photographs. investigators are hoping to find out which procedure is superior. this will allow investigators to provide the best treatment option for their patients in future.


Eligibility criteria:
inclusion criteria: * adult patient suffering from pilonidal disease willing to participate in study. exclusion criteria: * patients below the age of 16 years (not able to consent). * not consenting to participate in study. * patient with less than 3 cm between inferior opening of sinus and anus.