Kornimate/medical-research-clean huggingface dataset:
catheter-interventional treatment of pulmonary embolism

Conditions: Pulmonary Embolism

Summary: recent evidence supports the use of catheter-interventional techniques for the treatment of intermediate-high-risk pulmonary embolism. while there is evidence supporting the use of catheter-thrombectomy and alternatively local fibrinolysis, less is known on the combination of both approaches. the investigators aim to assess the effects of a combined interventional local fibrinolysis and catheter-thrombectomy and to compare them with conventional treatment in a cohort of patients with intermediate-high-risk pulmonary embolism.


Eligibility criteria:
inclusion criteria: * confirmed intermediate high-risk pulmonary embolism * age \>= 18 years exclusion criteria: * high-risk pulmonary embolism * contraindications for catheter-based treatment * known allergy to anticoagulant treatment or fibrinolytics * pregnancy * participation in other randomized trials * patients under legal supervision or guardianship
establishment of a tissue registry for hepatocellular carcinoma specimens

Conditions: Hepatocellular Carcinoma

Summary: the goal of the study is to establish a cancer registry to facilitate research and assist in the identification of additional risk factors for hepatocellular carcinoma. the main objectives are: 1. provide a mechanism to store the information about subjects with hepatocellular carcinoma 2. use of tissue samples for translational/further research purposes

the establishment of a tissue registry for hepatocellular carcinoma biopsy specimens for genetic and histologic research (tir-hcc) is a project aimed at addressing the high incidence rates of primary liver cancer in armenia. this initiative seeks to establish a cancer registry to support research efforts and identify additional risk factors associated with hepatocellular carcinoma (hcc). the study will involve patients of armenian descent who exhibit clinical, biochemical, and imaging evidence of hepatocellular carcinoma. data collection will include tissue and blood samples, which will undergo histologic and genetic analyses. additionally, relevant clinical history, laboratory results, imaging findings, and gut microbiota profiles will be collected. to ensure a comprehensive dataset, samples will be collected from eight institutions in armenia. the project aims to accumulate data from a total of 500 patients, providing a substantial pool for research and analysis. by establishing the tir-hcc registry, researchers hope to contribute to the understanding of hepatocellular carcinoma and potentially identify new risk factors associated with the disease. the collected data will aid in advancing knowledge of hcc and guide future strategies for prevention, early detection, and treatment.

Eligibility criteria:
inclusion criteria: * patients with biopsy-confirmed diagnosis of hcc * armenian descent * having given their signed informed consent exclusion criteria: * failure to obtain informed consent
eyedrop instillation technique

Conditions: Glaucoma; Glaucoma Suspect

Summary: eye drop instillation is a problem from glaucoma patients. studies reveal that 30-50% of glaucoma patients have problems instilling their eyedrops. these problems include not hitting the eye, spending many drops to get a single successful instillation and bottle contamination. the present study will evaluate the effect of encouraging patients to put their eyedrops using one of 2 techniques, randomly assigned, to determine which is more successful at instilling the eye drop into the eye while spending the least amount of drug. in one of the techniques the patient instills the eye drop with their eyes open in the inferior cul de sac. in the other technique the patient instills the eye drop with the eyes closed near the inner canthal region. patients will be randomized to encouragement to use the drops with either of the techniques. encouragement will take place over a visit where they will be subjected to: * baseline evaluation of eye drop instillation using their usual technique. * short (2-5 minute) educational session session for the assigned technique. * followup evaluation immediately after the educational session.


Eligibility criteria:
inclusion criteria: * glaucoma or glaucoma suspect * use of topical glaucoma medication in both eyes for at least 1 year prior to enrollment * va of 20/60 or better with habitual correction in at least one eye exclusion criteria: * previous history of allergy to fluorescein * received topical anesthesia for iop measurement or other reason within the last 2 hours. * rejects participation

Keywords: glaucoma randomized controlled trial eye drops instillation compliance
prospective study of extended robotic right hemicolectomy with complete mesocolic excision for cancer

Conditions: Colorectal Cancer

Summary: a single-center prospective study to elucidate whether extended robot-assisted right colectomy (e-rarc) performs as well as extended open right colectomy (e-orc) in terms of specimen quality, and in addition, whether less postoperative morbidity and shorter length of stay (los) can be attained. patients with colonic cancer near the right flexure or the oral part of the transverse colon will be compared excluding the most technically demanding and frail patients in both groups. a total of 40 patients undergoing e-rarc in a prospective series will be included and compared with 44 consecutive patients previously treated with e-orc.

complete mesocolic excision with central vascular ligation (cme) is an improvement of surgical technique in the operation for colonic cancer suggested to increase long-term survival. the concept was originally developed for open surgery by w. hohenberger in erlangen with excellent survival rates. however, if the tumor is located in the transverse colon or near the right colonic flexure, the procedure is particularly technically demanding, and for that reason most surgeons still prefer to do it by open operation (laparotomy) instead of the minimally invasive approach (laparoscopy) presently recommended for colonic cancer surgery. the advent of robotic surgery has improved the dexterity of instruments used in laparoscopic surgery and pushed the limits of what is possible with a minimally invasive approach. since minimally invasive surgery is associated with better outcomes in terms of postoperative morbidity, pain, length of stay etc., it would be highly desirable if cme surgery could be done by robot-assisted laparoscopic operation instead of the current open approach. the current single-center study is proposed to elucidate whether extended robot-assisted right colectomy (e-rarc) performs as well as extended open right colectomy (e-orc) in terms of specimen quality, and in addition, whether less postoperative morbidity and shorter length of stay (los) can be attained. patients with colonic cancer near the right flexure or the oral part of the transverse colon will be compared excluding the most technically demanding and frail patients in both groups. a total of 40 patients undergoing e-rarc in a prospective series will be included and compared with 44 consecutive patients previously treated with e-orc.

Eligibility criteria:
inclusion criteria: * suspected or verified colonic cancer visualized by colonoscopy and on ct in the anal part of the ascending colon, in the right flexure or in the oral 2/3 of the transverse colon * patient is 18 years or older, legally competent and able to comprehend information and give consent * tumor is uicc stage i-iii on preop ct * operation is elective exclusion criteria: * previous major open intraabdominal surgery * ileus or other acute abdominal condition * ct scan with suspicion of t4 tumor * rita score \> 3 (preop risk and frailty score) * bmi \> 35 kg/m2 * project surgeon not available

Keywords: robot hemicolectomy cancer
epidemiology and its results in hip fractures followed in postoperative intensive care

Conditions: Hip Fracture; Mortality Rate

Summary: type of study: observational study goal of this : we conducted a retrospective evaluation of patients with hf who received postoperative icu, with a focus on 30-day, 90-day and 1-year mortality outcomes. participant population/health conditions:patients over the age of 18 who are hospitalized in the intensive care unit of our hospital after hip fracture operation.

the proportion of elderly individual aged 65 and over in the global populatin is currently %9 and hip fractures (hfs) are a leading injury in this population worldwide. we conducted a retrospective evaluation of patients with hf who received postoperative icu, with a focus on 30-day, 90-day and 1-year mortality outcomes.

Eligibility criteria:
inclusion criteria: * patients with postoperative hip fractures hospitalized in the intensive care unit of our hospital exclusion criteria: * patients who do not have a hip fracture operation will not be included.
combination of ak104 and neoadjuvant chemoradiotherapy in pmmr/mss locally advanced rectal cancer

Conditions: Locally Advanced Rectal Cancer

Summary: this is an open-label, single-arm study to investigate the efficacy and safety of ak104 (an anti-pd1 and anti-ctla4 bispecific antibody) and neoadjuvant chemoradiotherapy in patients with pmmr/mss locally advanced rectal cancer.

the study evaluates the addition of ak104(an anti-pd1 and anti-ctla4 bispecific antibody) in neoadjuvant chemoradiotherapy in proficient mismatch repair (pmmr) /microsatellite stable (mss) locally advanced rectal cancer (larc). a total of 33 pmmr/mss larc patients will receive long-course chemoradiotherapy plus 2 cycles of ak104, followed by another 3 cycles of ak104, finally received clinical routine manage. the tumor response to treatment, adverse effects and long-term prognosis will be analyzed.

Eligibility criteria:
inclusion criteria: 1. age 18-75 2. ecog 0-1 3. rectal adenocarcinoma 4. ct3-4anany or ct1-4an+ 5. no distant metastasis 6. location ≤12 cm from the anal verge 7. positive pd-l1 expression (pd-l1 tps≥1% or pd-l1 cps ≥1) 8. the msi status is mss and pmmr 9. sufficient bone marrow, kidney and liver function 10. no previous surgery of the rectum, no previous chemotherapy, no previous pelvic radiation, no previous biotherapy, no immunotherapy exclusion criteria: 1. bowel obstruction 2. distant metastasis 3. severe arrhythmia, cardiac dysfunction (nyha grade iii or iv ) 4. uncontrollable severe hypertesion 5. active severe infection 6. cachexia, organ dysfunction 7. previous pelvic radiotherapy or chemotherapy 8. multiple primary cancers 9. epileptic seizures 10. malignant history within 5 years, except cervical carcinoma in situ or cutaneous basal cell carcinoma 11. persons deprived of liberty or under guardianship 12. impossibility for compliance to follow-up 13. certain or suspicious allergy to research drug 14. pregnant or breast-feeding woman
sandplay activity in psychiatry clinic (sapc)

Conditions: Sandplay Therapy; Anxiety

Summary: this research was conducted to examine the effect of sandplay activity on anxiety and well-being levels in patients in psychiatric clinics. the research was carried out in isparta süleyman demirel university psychiatric clinic as a single-blind randomized controlled experimental study in the pre-test, final-test order between 2020-2021. ethical permission was obtained from the clinical research ethics committee and application permission from the institution for pre-research. 63 patients (intervention-32 and control-31) selected by block randomization method formed the universe of the study. no intervention was applied to the control group. a preliminary test and a final test were performed two days apart, one hour apart on the first and fourth days. two sessions of sandplay activity were applied to the intervention group with a decongest of two days, and each session was pre-tested. the data was collected using "the personal information form", "the spielberger status anxiety" inventory, and "well-being star scale" and also data showed normal distribution. in statistical analysis, t-test, chi-square test, pearson correlation test was used dependent and independent groups. for the purpose of the research, the hypotheses of the research are as follows:: 1. hypothesis (h1): after intervention, anxiety levels of patients who underwent sandplay activity (in a psychiatric clinic) are lower than in the control grouproup 2. hypothesis (h1): after intervention the level of well-being of patients undergoing sand play activity (in a psychiatric clinic) is higher than that of the control group. 3. hypothesis (h1): there is a negative correlation between the level of anxiety and the level of well-being in psychiatric clinics who sandplay activity is practiced and not practiced. this research is turkish language.


Eligibility criteria:
inclusion criteria being over 18 years old, volunteering to participate, not having a defect in the ability to evaluate and reason the truth, not having hearing, understanding, and speaking problems, not have a physical disability exclusion criteria from research to be involved in another study on a similar experimental subject being on the first day of hospitalization and on the day of discharge removing criteria state their willingness to leave the research voluntarily transfer to another place and/or unscheduled early discharge

Keywords: anxiety, well-being, sandplay, psychiatric nursing, psychiatric care
a study of patient perception and quality of life associated with the use of olopatadine 0.2% in subjects with allergic conjunctivitis

Conditions: Allergic Conjunctivitis

Summary: the purpose of this study was to evaluate subject perceptions of olopatadine 0.2%, dosed once-daily, in subjects with allergic conjunctivitis and to record any adverse events as described by the subjects as a part of this post marketing surveillance study.


Eligibility criteria:
inclusion criteria: * history (within the past 24 months) of allergic conjunctivitis. * willing to avoid contact lens wear for each of the study visits, immediately prior to study medication installation and for 10 minutes after installation of study drug. * contact lens wear should be stable and consistent for 3 months prior to screening visit (day 1). * other protocol-defined inclusion criteria may apply. exclusion criteria: * contraindications or hypersensitivity to the use of the study medication or its components. * inability or unwillingness to follow all study instructions and complete study visits as required. * subjects with only one sighted eye or not correctable (using etdrs chart) to 0.6 log mar or better in both eyes at the screening visit. * a known history of recurrent corneal erosion syndrome (idiopathic or secondary to dry eye). * ocular trauma within six months prior to visit 1 in either eye as determined by subject history and/or examination. * other protocol-defined exclusion criteria may apply.
methodist health system covid-19 patient registry

Conditions: COVID-19

Summary: this is a prospective cohort observational registry study that will include data on all patients who are treated at mhs facilities for covid-19.

this is a prospective cohort observational registry study that will include data on all patients who are treated at mhs facilities for covid-19. data including, but not limited to demographics, comorbidities, medications, treatment, and clinical outcomes will be collected from february 2020 to december 2025. subjects will undergo no additional tests or procedures as part of this registry study. all patient data will be obtained from the patient's electronic health records (ehr) of the hospital or clinic in a retrospective manner. the process for gathering the data will not influence treatment decisions. there will be no direct patient contact associated with inclusion in this registry study.

Eligibility criteria:
inclusion criteria: * patient tested positive for covid-19 (sars-cov-2) * patient sought care for covid-19 at a mhs facility * aged 18 years or older exclusion criteria: * patient that do not have covid-19 * non-confirmed covid-19 patients * aged 17 years or younger
preventive use of corticosteroids during the post-partum in relapsing ms patients (copp-ms)

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is most prevalent among women of childbearing age. the post-partum (pp) period is a critical phase in ms patients, during which a recrudescence of disease activity is expected. different strategies have been assessed in the prevention of post-partum relapse. high dose methylprednisolone was evaluated in a case control study with historical controls but the positive results have not been confirmed. in this study, the main objective will be to compare the risk of relapse in the 6 months pp period between patients treated systematically by high dose methylprednisolone after delivery compared to patients who didn't receive a systematic treatment. the second objective will be focused on the comparison of the disease activity and disability progression in patients who have resumed early a disease modifying drug (dmd) after delivery vs patients who haven't.

even if two small case control studies underlined the positive effect of high dose methylprednisolone on the relapse risk in the pp period in ms, these data have to be confirmed by a larger study. the impact of such a strategy remains also uncertain concerning the risk of long term disability. in this project, the investigators will also analyze the influence of the delay of dmd reintroduction after delivery on the relapse risk but also on the risk of disability. the results will have an important role in the therapeutic management of the post-partum period in ms patients.

Eligibility criteria:
inclusion criteria: * relapsing ms patients according to macdonald criteria 2010 * age between 15 and 49 years old at the pregnancy * age between 18 and 51 years old when filling the questionnaire of the study * at least one full pregnancy with live birth after the beginning of the ms diagnosis * at least one neurological visit during the 12 months period after the delivery * at least one neurological visit per year in the 12 months preceding the pregnancy * pregnancy must occur between 01/2007 and 01/2017 in case of several pregnancies per woman, only the first one occurring in the period will be analyzed * having received information on the protocol and not having expressed opposition to participating in the study. exclusion criteria: * patients who have received immunoglobulines or plasma exchanges after the delivery in prevention of a relapse * patients presenting a spms or ppms form at the beginning of pregnancy * protected persons referred to in articles l. 1121-6 to l. 1121-9 of the code of public health (eg minors, persons deprived of liberty, ..) except nursing mothers postpartum.

Keywords: post-partum corticosteroids relapse disease modifying drugs (dmd)
effect of action observation training on gait variables and global cognitive functions

Conditions: Mild Cognitive Impairment

Summary: this study will investigate the effect of action observation teaining (aot) on gait variables and global cognitive functions in older adults with mild cognitive impairment (mci). the specific objectives are 1) to compare gait variables and global cognitive functions among the aot with gait training, gait training, and control groups at before training, after training, and follow up and 2) to compare gait variables and global cognitive functions among before training, after training, and follow up in each of the groups.

participants in this study will be older adults recruiting from the physical therapy center of mahidol university, siriraj hospital, and community at phuttamonthon area (n = 39). they will be diagnosed as a mci, using core clinical criteria of the national institute on aging and the alzheimer's association by a physiotherapist. prior to participate in the study, participants will be informed the details of the study and sign the informed consent. all participants will be recorded the demographic data and will be assessed visual acuity, hearing, sensation and muscle strength of lower extremity, balance, gait variables, and global cognitive function. participants who pass the criteria will be randomly assigned to either the aot with gait training group (n = 13), the gait training group (n = 13), and the control group (n = 13) by stratified randomization. gait variables will be collected by the force distribution measurement platform during walking at comfortable speed (single task) and during counting backwards from 100 by sevens (dual tasks). global cognitive function will be assessed by the montral cognitve assessment (moca). all varaibles will be assessed 3 times which will be at before training, after 4-week of training, and 4-week follow-up.

Eligibility criteria:
inclusion criteria: * aged 60-80 years old. * having subjective evidence of cognitive decline from patients, or from closely informants, or from a clinicians. * having objective evidence of cognitive decline, deﬁned by using a montreal cognitive assessment (moca) 18-24 points. * independent function in daily life * independent walking without using gait aids. * having fall risk, defined by the fall risk threshold (gait velocity \< 1 m/s in walking while counting backwards from 100 by sevens). * able to understand thai language and follow study protocol. exclusion criteria: * having history of stroke or heart attack or parkinsonism symptoms. * the presence of major depression disorder deﬁned by a patient health questionnaire-9 \> 9 points. * diagnosis as dementia by neurologists. * any cardiac or respiratory disease that could cause gait limiting. * musculoskeletal disorder that affected gait performance. * balance disorder in assessment day, such as vertigo and dizziness. * visual acuity with a glasses worse than 6/15 (metric system) in both their eyes.

Keywords: action observation training gait
a functional pain scale to improve the patient experience

Conditions: Pain Measurement

Summary: this will be an observational cohort study to evaluate pain measurement after surgery using a new functional pain scale.

patients admitted for orthopedic surgery may take part in this research. participants will be assessed using three different pain scales: numeric rating scale (nrs), faces pain scale and a new functional pain scale (fps).

Eligibility criteria:
inclusion criteria: * completed orthopedic (hip or knee) surgery * english as primary language and able to read * low risk as assessed by opioid risk assessment tool (orat) * no history of opioid abuse * patients with a diagnosis of chronic pain other than the scheduled hip or knee meeting the above criteria may be included. exclusion criteria: * previous diagnosis of cognitive impairment