Kornimate/medical-research-clean huggingface dataset:
comparison of efficacy between silicone ahmed glaucoma valves and second trabeculectomy in glaucoma patients

Conditions: Open Angle Glaucoma

Summary: in the management of open angle glaucoma, frequently more then one procedure is necessary to control the intra ocular pressure. there is still no consensus whether this second intervention should be a second trabeculectomy or a shunt device. in the present study we compare a second trabeculectomy versus ahmed silicone shunt device in open angle glaucoma patients with previous trabeculectomy without proper iop control.

in the management of open angle glaucoma, frequently more then one procedure is necessary to control the intra ocular pressure. there is still no consensus whether this second intervention should be a second trabeculectomy or a shunt device. in the present study we compare a second trabeculectomy versus ahmed silicone shunt device in open angle glaucoma patients with previous trabeculectomy without proper iop control. 40 patients with clinically uncontrolled open angle glaucoma with previous trabeculectomy surgery were selected from the glaucoma sector of federal university of sao paulo. patients were randomized to one of two groups: 1. silicone ahmed implant 2. second trabeculectomy surgery description: ahmed silicone tube implant: a fornix-based conjunctival flap was created between two adjacent recti muscles. before placement of the tube implant body to the sclera, tube was irrigated with saline solution to open the valve mechanism. the implant's polypropylene body was sutured to sclera with 6.0 silk suture. the tube then trimmed and the anterior chamber was entered from 1mm posterior to corneoscleral limbus with 23-gauge needle. a human donor scleral flap was placed over the tube and sutured to the sclera with 10.0 nylon suture. the conjunctiva was sutured to the limbus. second trabeculectomy: a fornix-based conjunctival flap was created in the opposite superior quadrant of the previous trabeculectomy. mitomycin-c was used under the conjunctival flap for up to 4 minutes (0,3mg/ml) and rinsed with 30ml saline solution. scleral flap with crescent bevel and sclerectomy with a punch. iridectomy and flap suture with nylon 10-0. conjunctival suture with nylon 10-0. follow up after surgery was in the 1st, 4th, 7th, 15th, 30th days and after that monthly or whenever needed for clinical reasons.

Eligibility criteria:
inclusion criteria: * patients with open angle glaucoma and uncontrolled iop despite the use of maximum tolerated glaucoma medication. * patients over 18 years old. * patients who can understand and sign the inform consent form. exclusion criteria: * other forms of glaucoma other than open angle glaucoma; previous psiquiatric condition ; * patients who can understand and sign the inform consent form; * visual acuity worse than hand motion; * previous retina surgery with buckle implant

Keywords: glaucoma drainage implant ahmed valve second trabeculectomy
investigating the relationships among illness cognition, social support, stress, and emotional reactions of infertile patients

Conditions: Infertile Patients

Summary: the current study attempted to explore the relationships among stressors (cognitions of illness, socioeconomic status, social support, marital stressor, social stressor, etc), perceived stress level, and emotional reactions (anxiety and depression) of infertile patients and to propose the measurement and structural models of infertile aniexty and depression.

the current study attempted to explore the relationships among stressors (cognitions of illness, socioeconomic status, social support, marital stressor, social stressor, etc), perceived stress level, and emotional reactions (anxiety and depression) of infertile patients and to propose the measurement and structural models of infertile aniexty and depression. structural equation modeling (sem) will be utilized through amos 17 to analyze the data, construct the initial model, and afterward present the modified structural model of the psychological responses for infertile patients.

Eligibility criteria:
inclusion criteria:male infertile patients(icd-9:606) and female infertile patients(icd-9:628). exclusion criteria:non-infertile patients.

Keywords: infertile patients
efficacy analysis of complete laparoscopic resection of recurrent hepatocellular carcinoma

Conditions: Recurrent Hepatocellular Carcinoma

Summary: this study is aiming to evaluate the clinical efficacy of complete laparoscopic resection of recurrent hepatocellular carcinoma (hcc).

the investigators conducted a prospective study of 64 patients who were diagnosed with recurrent hcc and underwent surgical resection at the sun yat-sen university cancer center from june 2014 to november 2014; 31 patients were enrolled in the laparoscopic group and underwent complete laparoscopic resection of hcc, and 33 patients were enrolled in the control group and underwent open surgical resection. the operation time, intraoperative blood loss, shortest distance between the tumor edge and normal liver tissue, postoperative pain scores, postoperative time until the patient could walk, postoperative time until the patient could pass gas, hospital stay, and inpatient costs were compared between the two groups. the patients were followed up for one year after surgery, and the relapse-free survival was compared between the two groups.

Eligibility criteria:
inclusion criteria: 1. recurrent hcc after open surgery 2. recurrent hcc located in any part of the left lateral lobe or the diaphragm side of the right lobe and near the surface of the liver, which resulted in an easier operation 3. no significant surgical contraindications 4. no major vessel or bile duct tumor invasion and metastasis 5. grade a or b liver function or grade c liver function that recovered to grade a after liver-protective treatment; 6. the patient and his/her family was willing to undergo laparoscopic resection. exclusion criteria: 1. major vessel or bile duct tumor invasion 2. recurrent hcc located in the right liver parenchyma and near secondary vessels and bile ducts, resulting in a difficult operation 3. grade c liver function 4. significant surgical contraindications 5. the patient and his/her family declined laparoscopic hepatectomy.

Keywords: laparoscopic hepatocellular carcinoma recurrence
evaluation of hifu in treatment of localized prostate cancer and of recurrence after radiotherapy

Conditions: Prostate Cancer; Ultrasound Therapy

Summary: to compare the efficacy of hifu treatment with standard treatment in two situations: 1. as first-line cancer treatment, hifu is compared to radical prostatectomy. 2. for patients with recurrence after external beam radiotherapy, hifu treatment is compared to radical prostatectomy.


Eligibility criteria:
general inclusion criteria * patients with localized adenocarcinoma of the prostate classified as t1-2, n0, nx m0 * classified as low or intermediate risk * patient with psa \< 15 ng/ml, gleason score ≤ 7 restricted to the form \[3 + 4\]. * biopsy with at least 12 specimens and a maximum of four out of six invaded sextants * patient with a pelvic mri if there is an intermediate risk and a bone scintigraphy if psa \> 10 ng/ml * patient affiliated with health insurance or beneficiary of an equivalent plan inclusion criteria for the hifu arm * patients 70 years of age or older * patients with a life expectancy related to age and associated illness estimated to be greater than 5 years inclusion criteria for total prostatectomy arm • patients with a life expectancy greater than 10 years and a state of health allowing general anaesthesia. non-inclusion criteria * patient participating in other biomedical research within 3 months prior to their inclusion in this protocol * included patient simultaneously participating in another research study

Keywords: hifu
exercise in hypoxia and nitrate supplementation in athletes: is the whole greater than the sum of its parts?

Conditions: Hypoxia

Summary: determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions.

determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions. it is hypothesized that the combined effect of these interventions will promote an additional performance and health improvement in this population at sea-level and altitude conditions, compared with the single effect.

Eligibility criteria:
inclusion criteria: * trained male subjects, regularly involved in competitive running, cycling and/ or triathlon events (4-5 times per week) in the past five years exclusion criteria: * smoking or other chronic issues * using medication or dietary supplements in the last 3 months, or during the duration of the study * being exposed to altitude (≥2000 m) in the last 3 months
gw572016 in patients with advanced or metastatic breast cancer

Conditions: Neoplasms, Breast

Summary: this study is designed to evaluate the efficacy and safety of gw572016 in patients with refractory breast cancer and consists of two cohorts of patients. patients in cohort a must have erbb2 overexpressing tumors while patients in cohort b must have non-erbb2 overexpressing tumors. patients eligible for this study must have advanced metastatic breast cancer who have previously received treatment with anthracycline and taxane.


Eligibility criteria:
inclusion criteria: * confirmed advanced (iiib or stage iv) breast cancer who have progressed on prior anthracycline and taxanes containing regimens + trastuzumab for cohort a patients. * patients must have adequate blood, liver, and kidney function and either be fully active or restricted only in performing strenuous activity. * female patients of child-bearing potential must be willing to abstain from intercourse from 2 weeks prior to administration of the first dose of study medication until 28 days after the final dose of study medication or be willing to consistently and correctly use an acceptable method of birth control. exclusion criteria: * patients with certain heart problems.

Keywords: lapatinib metastatic breast cancer trastuzumab (herceptin) stage iv breast cancer erbb2 erbb1
efficacy of 308-nm excimer laser for primary localized cutaneous amyloidosis treatment in asians

Conditions: Lichen Amyloidosis

Summary: efficacy of 308-nm excimer laser for primary localized cutaneous amyloidosis treatment in asians, pilot study.


Eligibility criteria:
inclusion criteria: * patients, aged \>18 years old with lichen amyloidosis diagnosed by using clinical presentation and pathologic features exclusion criteria: * those with cutaneous amyloidosis associated systemic diseases * pregnancy or lactating woman * those who are allergic to urea, olive oil * those who are photosensitive to ultraviolet radiation * those who had been previously treated with medications/ radiation/ laser within 3 months for systemic and 1 month for topical therapy

Keywords: 308-nm excimer laser primary localized cutaneous amyloidosis lichen amyloidosis asians
facilitation and barriers to breastfeeding in the nicu

Conditions: Breastfeeding; Prematurity

Summary: to date, there is a paucity of research focusing on maternal breastfeeding goals, how these goals may change after an unexpected event such as a preterm birth, and how mothers of ill and preterm infants define breastfeeding success. no studies were identified that focused exclusively on the breastfeeding goals of mothers of hospitalized preterm infants the purpose of this study is to answer the following research questions: 1) what are the breastfeeding goals of mothers with preterm infants in the nicu? and 2) what are mothers' perceptions of facilitators and barriers to meeting their breastfeeding goals in the nicu?

as the objective of this study is to describe the breastfeeding goals of mothers and their perceptions of breastfeeding support in the nicu, this study will follow a descriptive, qualitative design. mothers of preterm newborns in the royal victoria hospital will participate in a semi-structured interview about their breastfeeding goals and what they perceived to be facilitators and barriers to achieving their intended goals. during the interviews, the mothers will be asked a set of socio-demographic questions, open-ended questions about their breastfeeding goals, and open-ended questions about their perceptions of barriers and facilitators to meeting these goals in the nicu participants may also receive one follow-up phone call to clarify their responses to the questions or to validate the information obtained from the interview.

Eligibility criteria:
inclusion criteria: 1. have one (or more) infant(s) currently admitted in the nicu at the rvh; 2. intended to provide breast milk to their infant(s); 3. are able to speak english; and 4. are willing to be audiotaped during the interview. exclusion criteria: include mothers who: 1. never intended to breastfeed; 2. have high risk social situations (for example, known maternal mental illness; involvement of youth protection; known alcohol and drug abuse; adoption; identified congenital anomalies); 3. gave birth at term; and 4. have infants with significant birth defects or serious medical conditions in addition to prematurity.

Keywords: breastfeeding premature infants
impact of sleep apnea on sepsis mortality

Conditions: Sleep Apnea Syndromes; Sepsis; Mortality

Summary: by clinical record review, this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea, who were diagnosed and treated in taipei veterans general hospital, taiwan.

this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea (osa). patients with a diagnosis of sepsis, who had received a prior polysomnography at taipei veterans general hospital during jan. 1, 2001 to may 31, 2017 will be enrolled. obstructive sleep apnea (osa) is defined by an apnea-hypopnea index at least 5/hr with compatible symptoms. their clinical record will be reviewed and data including demography, polysomnography and details related to sepsis (source of infection, number of organ dysfunction at initial diagnosis of sepsis and survival time) will be collected. the start of the survival time (follow-up time) is the date when sepsis is diagnosed. the end of the survival time (follow-up time) is the date of death or end of hospitalization (date of discharge). survival analyses will be performed.

Eligibility criteria:
inclusion criteria: 1. patients who received received a polysomnography at taipei veterans general hospital during jan. 1, 2001 to may 31, 2017 2. patients who were admitted with a diagnosis of sepsis after the polysomnography 3. the diagnosis of sepsis fulfilling the clinical criteria exclusion criteria: 1. younger than 20 years 2. not compatible with a definition of sepsis 3. subjects with incomplete data

Keywords: obstructive sleep apnea sepsis outcome prognosis sleep-disordered breathing
impact of cataract surgery to socioeconomic status in rural area

Conditions: Cataract Surgery

Summary: this is a randomized controlled trial to investigate the effect of cataract surgery on the socioeconomic status of cataract patients in rural area of southern china.

cataract is the leading cause of visual impairment worldwide and surgery is the only effective treatment. previous studies show that visual impairment impacts the patient's socioeconomic status(ses). however, how cataract surgery affects the ses of cataract patients in rural area of china has not been determined before. in the investigators study, cataract patients in rural area of southern china will be enrolled and randomly divided into two groups. cataract surgery will be performed in 4 weeks in intervention group, while performed at 1 year later in control group. the annual personal income by work, annual household income, hours in paid and unpaid work in the previous month, real estate ownership, household expenditures and quality of life will be investigated before and 1 year after surgery. then, the difference in ses and quality of life change between two groups at 1 year later will be assessed.

Eligibility criteria:
inclusion criteria: * age-related cataract patients aged over 50 with best corrected visual acuity (bcva) less than 0.3 in the better eye. exclusion criteria: * history of other eye disease that contributes to visual impairment, including keratopathy, uveitis, glaucoma, retinopathy, ocular trauma, or intraocular surgery. * cases in need of expedited surgery, including shallow anterior chamber (central anterior chamber depth less than 2 mm and/or peripheral anterior chamber depth less than 1/4 corneal thickness), blindness of grade iv and v (bcva less than 0.02 in the better eye), and intumescent or hypermature stage of cortical cataract. * systemic disease dampening activity, including cardiovascular and cerebrovascular diseases, hemiplegia, neurodegenerative diseases such as alzheimer's disease and parkinson's disease. * patients not willing to participate in the study.

Keywords: cataract surgery socioeconomic status quality of life rural area china randomized controlled trial
diabetes journey: an adolescent adherence barriers intervention

Conditions: Type 1 Diabetes; Adherence, Patient

Summary: the purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a web-based intervention addressing adherence barriers in adolescents with t1d.

type 1 diabetes (t1d) treatment adherence is complex and involves glucose monitoring, counting carbohydrates, and intensive insulin delivery via injections or insulin pump in response to food intake, exercise, and illness to achieve near-normal blood glucose levels. evidence demonstrates that adhering to t1d treatment is challenging, especially during adolescence. non-adherence leads to suboptimal glycemic levels that severely compromise health and quality of life. suboptimal adherence to t1d treatment regimen is common in \>50% of adolescents and directly related to suboptimal glycemic control, increased risk of hospitalizations for diabetic ketoacidosis, and decreased health-related quality of life (hrqol). the maximum benefits of current diabetes technology are limited by the knowledge, skills, adherence barriers, and non-adherence behaviors.10-14 ultimately, adolescents have to overcome these barriers in order to benefit from technological advances. thus, there is a clear need for behaviorally focused interventions to identify and reduce adherence barriers. the overall objective of this study is to identify adolescents with elevated adherence barriers and provide novel tailored mhealth intervention (diabetes journey) targeting these barriers. this study is two phases and includes a small pilot of up to 12 adolescents with type 1 diabetes (phase 1) and a randomized controlled clinical trial (phase 2). the randomized controlled clinical trial will examine feasibility, acceptability and preliminary efficacy of diabetes journey versus enhanced standard of care (control group) in approximately 256 adolescents with type 1 diabetes. primary and secondary outcomes include adherence barriers, adherence, health-related quality of life and a1c. satisfaction and acceptability will also be examined. mediators and moderators will include executive functioning, diabetes distress, family conflict, depressive symptoms, fear of hypoglycemia and sleep.

Eligibility criteria:
inclusion criteria * t1d diagnosis \>1 year * adolescents with t1d ages 13-17 * elevations on the barriers to diabetes adherence questionnaire (scores of ≥3 of 53 for the stress/burnout and/or time pressure/planning subscales) based on their previous clinic visit scores * ability to read/speak english (all measures are in english) exclusion criteria * diagnosis of significant developmental disorders (e.g., autism spectrum disorder, moderate/severe developmental or intellectual disability) * comorbid medical diagnoses (e.g., cystic fibrosis, asthma) with the exception of endocrine disorders (e.g., celiac disease, thyroid) * no use of/plans to use non-insulin medication for blood glucose control

Keywords: adolescent mhealth executive functioning skills adherence barriers
chordart system for mitral regurgitation

Conditions: Mitral Valve Repair; Mitral Regurgitation; Mitral Valve Insufficiency

Summary: the chordart system is a novel catheter based technology for mitral chordal replacement that enables controlled implantation of artificial mitral chords to treat mitral regurgitation with a minimally invasive approach. the implant is designed to allow transfemoral antegrade implantation.

chordart utilizes a minimally invasive catheter based approach by which multiple artificial chordae are precisely positioned into the papillary muscle and then secured to the pathological leaflet.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * mitral regurgitation due to degenerative mitral leaflet prolapse or flail * left ventricular ejection fraction \>20% * new york heart association functional class ii to iv * able and willing to give informed consent and follow protocol procedures. exclusion criteria: * life expectancy \<1 year * hemodynamic instability * severe untreated ischemic disease * pulmonary hypertension * any prior mitral valve surgery or transcatheter mitral valve procedure * stroke or transient ischemic event within 30 days before randomization * patient is pregnant (urine human chorionic gonadotropin (hcg) test result positive), planning to be pregnant or lactating. * renal insufficiency * acute anemia * chronic obstructive pulmonary disease * severe right ventricular dysfunction * hepatic insufficiency * patient is participating in other investigational studies

Keywords: degenerative mitral leaflet prolapse heart disease minimally invasive
proximal versus distal segments of no-touch saphenous vein grafts

Conditions: Leg Wound Complication After No-Touch Harvestingof Veins

Summary: the optimum segment of no-touch veins for bypassing is still undefined. the purpose of this study is to assess the incidence of leg wound complication after no-touch harvesting of proximal segment of saphenous veins compared to distal segment of veins in the leg. graft occlusion rates between the two segments of veins for bypassing will also be compared during follow-up.

this is a prospective, single-center, open-label, randomized within-subject-controlled trial. we aim to randomize 100 patients undergoing isolated coronary artery bypass graft (cabg). we consecutively screen patients during the study enrollment period and seek informed consent from all eligible patients. in each patient, one saphenous vein graft (svg) will be randomized to be the proximal segment, while another will be the distal segment as control. healing of leg wounds will be assessed on day 6 post-operatively. follow-up will be performed via face-to-face interview until at least 1 year after the operation by ct angiography.

Eligibility criteria:
inclusion criteria: * patients aged 18 or older who undergo primary isolated open-chest cabg with two vein grafts, one to the left coronary territory and the other to the right, with or without cardiopulmonary bypass exclusion criteria: * concomitant cardiac or vascular surgeries (i.e. valve repair or replacement, maze surgery) * redo cabg * emergent cabg (cardiogenic shock, inotropic pressure support, iabp) * severe vein varicosity as assessed after vein harvesting and before randomization * use of vascular stapler for anastomosis * endarterectomy of coronary artery during surgery * left ventricular repair due to ventricular aneurysm * concomitant life-threatening disease likely to limit life expectancy to less than two years * severe renal insufficiency (i.e. creatinine \>200 μmol/l) * contraindications for dual antiplatelet therapy, such as active gastroduodenal ulcer * participant of other ongoing clinical trials

Keywords: leg wound complication no-touch saphenous vein harvesting technique coronary artery bypass graft