Kornimate/medical-research-clean huggingface dataset:
preoperative concurrent chemoradiotherapy for potentially resectable adenocarcinoma of the esophagogastric junction

Conditions: Gastroesophageal Junction Adenocarcinoma

Summary: stage i：preoperative therapy * capecitabine plus oxaliplatin with concurrent radiotherapy is superior to surgery alone ; stage ii: perioperative therapy * perioperative capecitabine plus oxaliplatin with concurrent radiotherapy is superior to adjuvant capecitabine plus oxaliplatin alone; * a regimen of capecitabine plus oxaliplatin(xelox) improves survival among patients with incurable locally advanced or metastatic adenocarcinoma of stomach and gastroesophageal cancer . the investigators assessed whether the addition of a perioperative regimen of xelox regimen with concurrent radiotherapy to adjuvant alone improves r0 resection rate and survival among patients with curable locally advanced adenocarcinoma of stomach and gastroesophageal cancer


Eligibility criteria:
inclusion criteria: 1. disease must be clinically limited to the esophagogastric junction, defined typeⅱ typeⅲ(from the endoscopic point of view according to the aeg criteria) 2. histologically confirmed primary adenocarcinoma 3. t2-4 n0-3 m0. t1 tumors are eligible if t1n1-3m0， 4. ecog performance status ≦2 aeg is defined and described as tumors which have their center within 5cm proximal or distal of the anatomical cardia. the classification of aeg type i, type ii and type iii aeg type i: adenocarcinoma of the distal esophagus,which usually arises from an area with specialized intestinal metaplasia of the esophagus, i barrett's esophagus, and may infiltrate the esophago-gastric junction from above; * aeg type ii: true carcinoma of the cardia, arising from the cardia epithelium or short segments with intestinal metaplasia at the esophago-gastric junction; * aeg type iii: subcardial gastric carcinoma, which infiltrates the esophago-gastric junction and distal esophagus from below. exclusion criteria: 1. tis (in-situ carcinoma) and tumors determined to be tin0 following endoscopy, endoscopic ultrasound and ct scanning. 2. patients with primary carcinomas of the esophagus. 3. prior chest or upper abdomen radiotherapy, prior systemic chemotherapy within the past 5 years, or prior esophageal or gastric surgery. 4. patients with evidence of metastatic disease are not eligible. 5. patients with a history of seizure disorder who are receiving phenytoin, phenobarbital, or other antiepileptic medication. 6. patients who cannot fully comprehend the therapeutic implications of the protocol or comply with its requirements. 7. patients with any medical or psychiatric condition or disease which, in the investigator's judgment, would make the patient inappropriate for entry into this study. 8. history of hypersensitivity to fluoropyrimidines, capecitabine, oxaliplatin or the ingredients of this product -

Keywords: capecitabine oxaliplatin preoperative concurrent chemoradiotherapy gastroesophageal junction adenocarcinoma
quantification of viral load in the upper respiratory tract in patients treated with olsetamivir for influenza

Conditions: Flu

Summary: seasonal influenza is a frequent disorder with high impact on morbidity and mortality and significant burden on healthcare-related cost. in france, the 2018-2019 flu epidemic has led to 13,100 all-cause death including 9,900 death directly related to the viral infection. as cross-transmission of influenza is responsible for nosocomial outbreaks, preventing transmission of infectious agents in healthcare settings is a major issue. if vaccination of patients and healthcare givers remains cornerstone, control procedures are mandatory. therefore patients admitted with influenza require isolation precautions including admission in a single room and protective measures. based on experts advise, isolation is currently recommended for 5 to 8 days. duration of isolation depends on immune status and antiviral therapy. however, during periods of epidemic, every hospital room is valuable and each ressource has to be tightly used. risk of contamination is related to the presence of influenza in the upper airways. to the promoteur 's knowledge, presence of influenza in the upper airways has not been studied in patients receiving oseltamivir. the question is : do duration of isolation in patients admitted with flu decreas when they are treated with antiviral therapy. to answer this question the promoteur would aim to determine influenza carriage in the upper airways in in-patients treated by olsetamivir.


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years) * positive testing for influenza (a or b) * patients hospitalized and treated with olsetamivir * signature of informed consent * affiliation to healthcare insurance (france, monaco) exclusion criteria: * refusal to participate * admission to intensive care * palliative care * unable to give inform consent * patients under legal protection
video-assisted telephone cpr with the emergencyeye-software - a pilot study - proof of concept

Conditions: Cardiac Arrest

Summary: technical advance as broad-bandwidth wireless internet coverage and the ubiquity utilization of smartphones has opened up new possibilities which surpass the normal audio-only telephony. high quality and real-time video-telephony is now feasible. however until now this technology hasn't been deployed in the emergency respond service. in the hope of helping the detection of the cardiac arrest, offer the possibility to evaluate and correct via a video-instructed cpr (v-cpr) and to facilitate a fast localization of the emergency site, a new software (emergencyeye®/ramses®) was developed which enables the dispatcher a video-telephony with the callers mobile terminal (smartphone) if suitable. this technology hasn't been tested in a randomized controlled trial in real environment conditions yet. this is to be done in this study.

technical advance as broad-bandwidth wireless internet coverage and the ubiquity utilization of smartphones has opened up new possibilities which surpass the normal audio-only telephony. high quality and real-time video-telephony is now feasible. however until now this technology hasn't been deployed in the emergency respond service. in the hope of helping the detection of the cardiac arrest, offer the possibility to evaluate and correct via a video-instructed cpr (v-cpr) and to facilitate a fast localization of the emergency site, a new software (emergencyeye®/ramses®) was developed which enables the dispatcher a video-telephony with the callers mobile terminal (smartphone) if suitable, and automated localisation of the caller. this technology hasn't been tested in a randomized controlled trial in real environment conditions yet. this is to be done in this study.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * cardiovascular diseases * pulmonary diseases * pregnancy * all other conditions that make cpr impossible
intensive smoking and alcohol cessation intervention in bladder cancer surgery patients

Conditions: Bladder Cancer; Smoking; Alcohol Consumption

Summary: radical cystectomy provides the best cancer-specific survival for muscle-invasive urothelial cancer. however the postoperative morbidity remains at 11-68 %. smoking and alcohol consumption above two drinks per day is associated with an increased risk of postoperative morbidity. six-eight weeks of smoking and alcohol abstinence prior to elective surgery is recommended to reduce this risk, but for cancer patients the preoperative period is often very short. this randomised clinical trial (stop-op) will reach a conclusion on the effect of a new gold standard programme for both smoking and alcohol cessation intervention using the gold standard programme (gsp) on the frequency and severity of postoperative complications after bladder cancer surgery.

the study is a multicentre randomised clinical trial involving 110 patients with a risky alcohol intake (exceeding 21 alcohol units (252 g ethanol) per week or/ and daily smoking scheduled for bladder cancer surgery. patients will be randomised to the 6-weeks gsp or treatment as usual (control). the gsp combines patient education and pharmacologic strategies. the gsp includes benzodiazepine therapy for withdrawal symptoms, controlled disulfiram therapy, and nicotine replacement.

Eligibility criteria:
inclusion criteria: * patients \> 18 years scheduled for cystectomy due to bladder cancer * daily smoker or/and intake of -\>21 units (252 g) of alcohol pr week * informed consent exclusion criteria: * cancelled operation * hypersensitivity to benzodiazepines, disulfiram or nicotine replacement * pregnant or breastfeeding women * mentally incompetent patients

Keywords: radical cystectomy bladder cancer smoking cessation alcohol cessation postoperative complications
the effects of atorvastatin on the nitric oxide-system in healthy young man

Conditions: Cardiovascular Diseases; Nephropathy

Summary: it has been documented that statin reduce mortality and morbidity in patients with cardiovascular disease. this effect can partly be related to a reduction in cholesterol levels in blood. nitric oxide (no) production is reduced in several chronic diseases such as nephropathy, diabetes and hypertension. the purpose of this study is to investigate the effect of atorvastatin treatment on the no-system measuring renal and cardiovascular variables in healthy man.

subjects will be examined on two examination days. 4 days prior to each examination day subjects are treated with either atorvastatin or placebo. during treatment periods subject are given a standardized diet. on the examination days subject are given l-nmma(l-ng-monomethyl arginine citrate), a no inhibitor, 6 mg bolus infusion followed by continuous 4 mg/kg/hr infusion for 1 hour. renal function, central hemodynamic and vasoactive hormones are evaluated prior, during and after l-nmma infusion. renal function is measured by renal clearance of 51cr-edta and urinary sodium, potassium and albumin concentration. urinary excretion of protein from sodium channels such as the nacl cotransporter (ncc), the na-k-cl cotransporter (nkcc) and the epithelial sodium channel (enac)will be measured to evaluate channel activity in the nephron. central blood pressure, pulse wave analysis, and augmentation index are measured using sphygmocor® from atcor. the vasoactive hormones aldosterone, renin, angiotensin ii, atrial natriuretic peptide (anp), brain natriuretic (bnp) and endothelin is measured in plasma

Eligibility criteria:
inclusion criteria: * men and women, age 18-40 years * body mass index (bmi) 18,5-30 kg/m2 exclusion criteria: * arterial hypertension (\>140 mmhg systolic and/or 90 mmhg diastolic) * anamnestic or clinical signs of heart, lung, lever, kidney and brain disease * neoplastic disease * alcohol abuse, * drug abuse * medical treatment except oral anticontraceptive * smoking * pregnancy or * abnormal blood and urine sample * abnormal ecg * blood donation within a month before examination

Keywords: statin l-nmma healthy subjects nephrology
micro study: detecting bacterial infections related to orthopaedic surgical implants

Conditions: Open Reduction and Internal Fixation of Extremity Fractures

Summary: a prospective trial conducted at shock trauma of patients between 18 years of age and older who have sustained a fracture with metal implanted. the investigators will be collecting between 1-3 routine blood draws for the purpose of laboratory analysis to assess biofilm growth. patients may be infected or non-infected at the time of blood draw; they will be selected at random for purposes of this study. all patients will be followed as standard of care by their treating physician for all their follow up visits.

surgical site infection in the orthopaedic surgery population is a significant public health issue. wound infections result in both increased length of hospital stay and total cost of care. surgical site infection (ssi) is the most common preventable adverse outcome after a major operation. the economic costs to the us healthcare system are enormous estimated to be in excess of $1.8 billion per year. for patients who develop an ssi, the cost may be even higher with length of stay and risk of death doubled. thus the benefits of any intervention decreasing the risk of ssi are very tangible. a biofilm is a layer of bacteria that adheres to a surface; in orthopaedics, this often means adherence to implanted metal after fracture surgery. the test that has been designed by one of the investigators on the study has been shown in an animal model to detect the formation of a biofilm up to 1 month prior to clinical detection. having a blood assay such as this would allow earlier antibiotics and potentially prevent the need for further surgeries to remove metal implants and clean out the biofilm.

Eligibility criteria:
inclusion criteria: * previous fracture fixation with an implant (intramedullary nail, plate, screws), or joint revisions, or periprosthetic fracture, or admitted from orthopaedic trauma clinic due to infection, or inpatient with a known infection. * english speaking exclusion criteria: * patients with planned follow-up at another medical center * patient lives outside of the hospital catchment area

Keywords: methicillin-resistant staphylococcus aureus (mrsa) infection biofilm assay
identifying the effect and working mechanisms of myplan 2.0 in older adults

Conditions: Overweight

Summary: the aim of this study is to investigate whether and how 'myplan 2.0' helps older adults to be more physically active or less sedentary. two groups will be created, an intervention group and a waiting-list control group.

the aim of this study is to investigate whether and how 'myplan 2.0' helps older adults to be more physically active or less sedentary. two groups will be created, an intervention group and a waiting-list control group. both groups will be tested during three testing waves: pretest, posttest and follow-up test. only the intervention group will be given acces to 'myplan 2.0'. 'myplan 2.0' consists of a website and mobile application targeting physical activity and sedentary behaviour. the intervention has a duration of five weeks.

Eligibility criteria:
inclusion criteria: * have access to internet * being computer literate exclusion criteria: * non dutch speaking

Keywords: physical activity sedentary behaviour ehealth mhealth self-regulation behaviour change techniques
vitamin d receptor polymorphisms and efficacy of vitamin d-fortified yogurt drink in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: study is a 12-week double blind,controlled experiments designed to examine the possible effects of vitamin d receptor gene polymorphisms on the metabolic, inflammatory and oxidative stress markers in type 2 diabetic patients to vitamin d-fortified yogurt drink intake.

in a 12-week randomized controlled trial ( double-blind study), based on data on serum 25(oh)d changes from other studies (35), to achieve 1 standard deviation difference in circulating 25(oh)d with two-sided alpha of 0.05 and a beta of 0.2 after a 12-week intervention period, the sample size was calculated 40 individuals per treatment group. considering 3 polymorphic variant groups and one control group which receives plain yogurt drink, 160 subjects are needed. allowing for 10% attrition over 12 weeks of intervention, a total of 180 subjects are required. in treatment groups, all patients receive 500 ml per day of low-fat (1%) yogurt drink fortified with approximately 500iu of vitamin d3 . control group receives 500 ml per day of plain (unfortified) yogurt drink. metabolic, inflammatory and oxidative stress markers are evaluated at the beginning and in the end of the interventional period.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * informed consent * bmi between 25 to 35 kg/m2 * age: 30-45 years old * willingness to maintain current body weight for the duration of the study * willingness to maintain baseline lifestyle activities and routines for the duration of the study * willingness to avoid the use of all over-the-counter or prescription vitamins, dietary supplements, and herbal products during the study exclusion criteria: * history of cardiovascular , gastrointestinal , renal disease and any other endocrinological disorders * subjects receiving vitamin d or omega-3 supplement * pregnancy , or lactation within the study period * treatment with insulin * treatment for weight reduction * treatment for reducing serum lipids

Keywords: vitamin d fortification yogurt drink efficacy
the accessit study

Conditions: Respiratory Support

Summary: the study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.

in patients with spinal cord injury, separation from mechanical ventilation is an essential aspect of the prognosis. denervation of specific muscles, as a consequence of the injury, can generate a dysfunction of the involved muscles and/or a disruption of their coordination during breathing. respiratory muscle dysfunction is strongly associated with failure of weaning from mechanical ventilation. however, the pattern of activation and coordination of the different respiratory muscles, as well as their evolution over time, have been poorly investigated in spinal cord injury, particularly during the acute phase in intensive care unit. assessing the structure, activity, and function of the respiratory muscles at different time points after the injury would help to better understand the natural course of respiration in these patients and the possible therapeutic approaches. in fact, depending on the activation/deactivation and residual function of the respiratory muscles, there might be potential for recovery and training, with the possibility of improving patients' clinical outcomes. in this preliminary physiological study, the investigators aim to assess the feasibility of monitoring non-invasively the respiratory muscles in mechanically ventilated adult patients with traumatic spine lesion, with and without spinal cord injury. the investigators also aim to assess, monitor, and compare over time the structure, degree of activation, function, and coordination of the different respiratory muscles. because the diagnosis of spinal cord injury is not always made immediately in spine trauma patients, and because other factors related to chest or abdominal trauma could interfere with the respiratory pattern, the plan is to study and follow patients with spinal cord injury, using patients with traumatic spine lesion without spinal cord injury as controls.

Eligibility criteria:
inclusion criteria: * presence of traumatic spine lesion (with and without spinal cord injury) * requiring invasive mechanical ventilation, via oro-tracheal or tracheostomy tube, * 16 years of age or older * patient or substitute decision maker able to provide consent exclusion criteria: * expected withdrawal of treatments within 24 hours of screening * chronic respiratory failure already treated with mechanical ventilation before the injury * documented pre-existing neuromuscular diseases

Keywords: spinal cord injury trauma respiratory muscles mechanical ventilation acute respiratory failure diaphragm dysfunction
anti-eryptotic effect of a food supplement with plants sterols in hypercholesterolemia treated with statins

Conditions: Cardiovascular Diseases; Hypercholesterolemia; Atherosclerosis

Summary: potential anti-eryptotic effect of a regular intake of a plant sterol (ps)-containing food supplement, in moderate hypercholesterolemic patients treated with the ps-containing food supplement or placebo supplement.

oxidative damage has been related to the externalization of phosphatidylserine in erythrocytes, an event associated with eryptosis (programmed death of erythrocytes). in addition, an increase in eryptosis has been observed in patients with hypercholesterolaemia. ps-enriched food supplements could be a nutritional strategy to improve risk factors in patients with moderate hypercholesterolemia treated with statins, constituting a synergistic treatment with these drugs. the present study aims to evaluate the eryptotic process (externalization of phosphatidylserine) after regular intake of a food supplement containing ps (2g/day) in patients with moderate hypercholesterolemia treated with statins. this is a case-control study with 32 cases (intake or a ps-containing food supplement) and 16 controls (placebo intake based on the excipient), with an intervention period of 6 weeks. the evaluation of eryptosis is carried out by determining the externalization of phosphatidylserine, the size of the erythrocytes and an ex vivo assay of adhesion of eryptotic erythrocytes to the vascular endothelium. in addition, the redox state (gsh), the in vivo oxidation of cholesterol (cops), and biochemical and hematological parameters are evaluated. all parameters are evaluated at the beginning (week 0) and at the end of the intervention period (week 6).

Eligibility criteria:
inclusion criteria: * participants with hypercholesterolemia (ldl cholesterol ≥ 160mg/dl at the time of diagnosis), receiving treatment with moderate intensity statins (atorvastatin 10-20 mg or simvastatin 20-40 mg or rosuvastatin 5-10 mg) * no previous episodes of cardiovascular disease * absence of other analytical abnormalities or previous illnesses exclusion criteria: * diabetes mellitus * participants in secondary prevention * treatment with lipid-lowering drugs other than atorvastatin, simvastatin or rosuvastatin * liver disease * renal failure * uncontrolled hypothyroidism * smokers * participants consuming foods enriched with ps or food supplements that contain ps

Keywords: cholesterol plant sterols eryptosis cholesterol oxidation products
blood types and erectile dysfunction

Conditions: Erectile Dysfunction

Summary: the researchers aimed to investigate the relationship between abo blood types and erectile dysfunction.

this retrospective study is done in ordu university hospital among patients who administered to urology polyclinic between april 2013 and april 2014. sexually active 102 patients whose blood types were known were included in this study. while 56 patients had sexual intercourse problems 46 had not and this group was taken as a control group. individuals who had a sexual partner and whose sexual intercourse were continuing unproblematic ally were accepted as normal. individuals who had not have sexual intercourse though having a sexual partner or unable to maintain the intercourse were accepted to have sexual dysfunction. patients' sexual function was evaluated via the i̇eff-5 questioning form. in the same session the patients' blood types were also recorded and their i̇eff-5 (erectile function international evaluation form) symptom scores were compared with their blood types.

Eligibility criteria:
inclusion criteria: * male, person who have sexual intercourse exclusion criteria: * female, who have no sexual intercourse

Keywords: blood group antigens erectile dysfunction