Kornimate/medical-research-clean huggingface dataset:
characterization of the digestive functions and the enteric nervous system in obesity. investigations of relationships with metabolism disorders (enteroneurobesity)

Conditions: Obesity

Summary: 60 patients scheduled for bariatric surgery will be included into 3 categories (20 patients with non complicated obesity, 20 patients with metabolic syndrome and 20 patients with a type 2 diabetes or hypertension). 20 volunteers will be enrolled as normal referents. the patients and the volunteers will have a classical pre-operative check-up (fibroscopy, oesophageal phmetry and manometry) and extra investigations as isotopic gastric empty exam, lactulose oro-caecal transit exam, intestinal permeability test calculated by lactulose-manitol ratio urinary excretion. intestinal and colonic biopsies will be also provided for studying permeability. for only patients, samples from the gastric resection will be provided for analysing the enteric nervous system and motricity.


Eligibility criteria:
patients: patients must be aged between 18 and 65 years old with a bmi\>40kg/m2 for non complicated patients or with a metabolic syndrome and with a bmi\>35kg/m2 for patients with type 2 diabetes or hypertension. they must be eligible for bariatric surgery. patients with a type 1 diabetes, neurologic or neuro-degenerative disease will be excluded. volunteers: volunteers must be aged between 18 and 65 years old with a bmi between 20 and 25kg/m2 men and women are eligible.

Keywords: patients eligible for bariatric surgery (bmi>40kg/m2)
combined anticholinergic medication and sacral neuromodulation to treat refractory overactive bladder

Conditions: Overactive Bladder

Summary: this study is a retrospective chart review including all patients who received surgical placement of a snm device with dr. noblett from 2001 to the present.

the following data will be collected from patient charts: age at time of surgery, gravidity/parity, body mass index, pre-existing medical conditions/surgical history, current medications, menopausal status, form and severity of oab symptoms, other previously or currently used interventions, method of snm device placement, observed motor/sensory response, percent improvement of symptoms, follow-up oab symptoms, frequency of interstim settings adjustments, adverse events, significant changes in health, and incidence/reason for drop out.

Eligibility criteria:
inclusion criteria: * female patients with symptoms of oab, namely urge incontinence and urgency-frequency. * ages 18 and older. exclusion criteria: * any patient who received surgical placement of an snm device to treat non-obstructive urinary retention, or the symptoms of an underlying neurologic pathology, such as parkinson's or multiple sclerosis.

Keywords: snm device chart review of patients with surgical placed snm device
a study to evaluate different targeted therapies for patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. this study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active rheumatoid arthritis (ra). this study currently includes 3 substudies evaluating different treatments in participants with ra. substudy 1 will evaluate lutikizumab compared to placebo (looks like the study treatment but contains no medicine). substudy 2 will evaluate ravagalimab compared to placebo and substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (b/tsdmard) therapies will be enrolled in the study at approximately 65 sites worldwide. there may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. participants will attend regular visits during the study at a hospital or clinic. the effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.


Eligibility criteria:
inclusion criteria: * at any time prior to the screening visit, participant must have been treated for \> or = 3 months with at least 1 b/tsdmard therapy but continued to exhibit active ra, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. the maximum cap for prior use of b/tsdmard is 2. * participant must be on a stable dose of methotrexate (mtx) exclusion criteria: * participant is taking nonsteroidal anti-inflammatory drugs (nsaids), acetaminophen/paracetamol, low-potency opioids (tramadol, codeine, hydrocodone, alone or in combination with acetaminophen), oral corticosteroids (equivalent to ≤ 10 mg/day of prednisone), or inhaled corticosteroids for stable medical conditions unless they have been on stable doses for ≥ 1 week prior to baseline visit. * history of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than rheumatoid arthritis.

Keywords: rheumatoid arthritis
association of low vitamin d levels with mortality in patients with reduced left ventricular function referred to cardiac surgery

Conditions: Malnutrition

Summary: this study investigates if reduced serum levels of vitamin d concentration are a typical feature in patient group with low left ventricular function admitted for cardiac surgery interventions. and also the necessity of more preventive strategies for adequate nutrition of these patients with more focus on intake of vitamin d before admission to cardiac surgery.


Eligibility criteria:
inclusion criteria: * all routinely cardiac procedures exclusion criteria: * dialysis, cancer

Keywords: vitamin d malnutrition cardiac surgery study emphasize importance significant high risk patient
the feasibility, potential efficacy, and experiences of using a group-based acceptance and commitment therapy among older people with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: no study has investigated the effects of act on community-dwelling chinese older adults. given that clinical practice guidelines have recommended exercise therapy for treating people with clbp, a combination of act and exercise therapy may yield better clinical outcomes than exercise alone among community-dwelling older adults with clbp. a double-blinded (participants and statistician) pilot randomized controlled trial (rct) will be conducted to evaluate the feasibility and the relative effects of act plus back exercise training as compared to exercise alone in improving psychological flexibility, physical wellbeing, and quality of life of community-dwelling older people with clbp. further, a qualitative research study will be conducted to understand the experiences of participating in act and back exercise training in older people with clbp (including identifying facilitators and barriers to participation).

participants will be recruited from rehabilitation clinics, or community centres by posters posted in these locations. a total of 30 older people with lbp will be recruited and randomized into either a 4-week act plus back exercise group, or a back exercise control group. immediately after the 4-week treatment, participants will be invited to complete another set of questionnaires that are identical to their baseline questionnaires to evaluate the effects of interventions on their pain, physical function, psychological wellbeing, and quality of life. at 3-month post-treatment, participants will be invited to complete the identical questionnaires again.

Eligibility criteria:
inclusion criteria: 1. have non-specific lbp in or near the lumbosacral spine with or without leg pain that lasts for at least 3-months in the last 12 months 2. have sought some medical or healthcare professional treatments for clbp 3. able to read and write at an adequate level of proficiency in chinese 4. mini-mental status examination (mmse) scores 23 or above exclusion criteria: 1. people with malignant pain or lumbar spinal stenosis 2. confirmed dementia 3. severe cognitive impairment 4. serious psychiatric or psychological disorders 5. mini-mental status examination (mmse) scores below 23

Keywords: chronic low-back pain (clbp) acceptance and commitment therapy (act) psychological flexibility
molecular epidemiology of therapy-related acute myeloid leukemia/myelodysplastic syndrome (aml/mds)

Conditions: Leukemia; Myelodysplastic Syndrome

Summary: the goal of this research study is to identify biologic and lifestyle factors that may increase a person's risk of developing acute myeloid leukemia or myelodysplastic syndrome after treatment for a previous cancer (treatment-related aml/mds).

for this study, you will be asked to take part in a personal or mail interview. during the interview, you will be asked questions about your demographics (age, sex, etc.), any chemicals you may have been exposed to, your medical history, family history of cancer, your diet, and your smoking and alcohol use histories. it should take around 50 minutes to complete the interview. treatment information from your medical records at m. d. anderson will also be collected. you will be asked to provide a saliva sample or have around 1 tablespoon of blood drawn for special tests. these tests will look for biologic factors associated with treatment-related aml/mds. your participation in this study will be over once the interview has been completed and blood or saliva have been collected. this is an investigational study. up to 600 participants will take part in this study. all will be enrolled at m. d. anderson.

Eligibility criteria:
inclusion criteria: 1. age 18 years or older 2. willing and able to provide written informed consent and authorization 3. willing to donate a saliva sample or 10 ml of blood and to complete a self-administered or personal interview 4. a histologically confirmed diagnosis of aml or mds (cases only) 5. a history of a previous primary malignancy that was treated with chemotherapy and/or radiation therapy (cases only) 6. enrolled in leukemia/mds studies under protocol id00-173 or id03-0250 (cases only) 7. treated for a primary malignancy at mdacc (controls only) 8. matched to cases (2:1) by cases' prior malignancy(site, treatment (chemo and/or radiation), year of diagnosis (+/- 3 years)), age (+/- 5 years), sex, and ethnicity. (controls only) exclusion criteria: 1. under 18 years of age 2. history of second primary malignancy (controls only)

Keywords: acute myeloid leukemia myelodysplastic syndrome leukemia mds aml malignancy molecular epidemiology epidemiologic markers clinical markers constitutional genetic markers case-comparison study
educational intervention on celiac disease and gluten-free diet through social networks (glutlearn project).

Conditions: Celiac Disease

Summary: celiac disease (cd) is an autoimmune disease that occurs in people who are genetically predisposed to gluten consumption (1). the prevalence of the disease is about 1-2% and it is more common in women than in men, and in children than in adults (2). the only current treatment for celiac disease is a strict, lifelong gluten-free diet. this involves the complete elimination of gluten from the diet. gluten is not only present in some cereals such as wheat, rye, barley and oats, but is also found in many foods that have been processed. in addition to being safe, the gluten-free diet must also be balanced. following a gluten-free diet creates psychological and social problems for the people who have to follow it (3). it has been seen in several studies that people with celiac condition can feel different and excluded, as it is difficult to eat out, to make sure that the food is gluten-free and to avoid cross-contact (4-8). due to the complicate situation of people with celiac disease, they do not hesitate to seek information about the management of their diseas. that is why people with celiac disease turn to social networks, as a rapid, visual and accessible way to share information (9-11). in line with the objectives of the university to which the gluten3s research group belongs to (university of the basque country, upv/ehu), the group has been aware for some time of the importance of disseminating science on social networks in order to make the results of the research reach the general public. it is considered that creating a nutritional education programme about cd and gluten-free diet (gfd), delivered by experts in the field, could be useful in improving knowledge and attitudes about this matter. this will empower people with cd to improve their self-care and take control of their situation. furthermore, it is also interesting to design the programme in such a way that the impact of the intervention can be measured, always with the intention of continuous improvement and reaching people with celiac disease and their environment in an effective way. the educational intervention will be carried out for one month and is aimed at adults with coeliac disease or adults with coeliac relatives who are involved in their care. each day a post will be uploaded to instagram with specific, accurate and current information. the content of the intervention has been divided into 5 main blocks: 1) general concepts about cd, 2) balanced gfd, 3) food labelling, 4) cross-contact/cross-contamination, 5) new research on cd and useful resources for disease management. the evaluation of the intervention will be carried out through pre- and post-intervention questionnaires.


Eligibility criteria:
inclusion criteria: * be of legal age * have celiac disease or be involved in the care of a person with celiac disease * be an instagram user

Keywords: celiac disease nutrition education gluten-free diet balanced diet social networks
panretinal photocoagulation (prp) plus ranibizumab for proliferative diabetic retinopathy

Conditions: Diabetic Retinopathy; Retinal Neovascularization

Summary: the purpose of this study is to evaluate the effects of panretinal photocoagulation plus intravitreal ranibizumab for the treatment of patients with high risk proliferative diabetic retinopathy in terms of changes in visual acuity and neovascularization area.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * high risk proliferative diabetic retinopathy * visual acuity ≥ 20/800 * no previous laser treatment for diabetic retinopathy exclusion criteria: * previous pars plana vitrectomy * systemic thrombo-embolic events * uncontrolled systemic hypertension * conditions avoiding adequated documentation * previous eye surgery in the last 6 months before inclusion in the study

Keywords: proliferative diabetic retinopathy retinal neovascularization angiogenesis inhibitors ranibizumab laser
effects of circadian rhythm on glycemic regulation during continuous moderate exercise and intense intermittent disease in adolescents living with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes

single-center, randomized, controlled study in adolescents living with type 1 diabetes. this study aims to evaluate the effect of exercise timing (morning vs. afternoon) and exercise type (continuous vs. intermittent) on blood glucose levels during and after exercise, as well as to assess the effect of exercise timing (morning vs. afternoon) and type of exercise (continuous vs. intermittent) on blood glucose during and after exercise

Eligibility criteria:
inclusion criteria: * children and adolescents aged 10 to 16; * living with type 1 diabetes for at least 1 year with hba1c less than or equal to 12%; * socially insured ; * having given their written consent to participate in the research, as well as that of their legal guardians; * willing to comply with all research procedures and duration. exclusion criteria: * clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate less than 40 ml/min), neuropathy or severe proliferative retinopathy as assessed by the investigator; * recent acute macrovascular event (\< 3 months), e.g. acute coronary syndrome or cardiac surgery; * abnormal blood picture and/or anemia; * current pregnancy; * other serious medical condition likely to interfere with study participation or ability to complete exercise periods in the judgment of the investigator (e.g., orthopedic limitation); * inability to receive informed information; * inability to participate in the entire study; * lack of social security coverage; * refusal to sign consent form.

Keywords: adolescents type 1 diabetes glycemic regulation circadian rhythm
the prevention of thromboembolic complications associated with coil embolization

Conditions: Thromboembolic Stroke; Aspirin; Clopidogrel; Coil Embolization; Prevention

Summary: clopidogrel has been to be reported to be superior to aspirin for the prevention of thromboembolic complications associated with coil embolization in patients with ruptured aneurysms.


Eligibility criteria:
inclusion criteria: * all the patients enrolled in the study underwent mri and angiography. * participants included in the study were confirmed on assessment, and verified for ruptured aneurysm by imaging using either computed tomography (ct) or mri. exclusion criteria: * patients with any history of sensitivity or reaction to aspirin, or any contraindication for mri, were excluded from the study.
a study to evaluate mk0476 and fluticasone to control asthma in patients with mild persistent asthma (0476-910)

Conditions: Asthma, Bronchial

Summary: a study to evaluate mk0476 and fluticasone to control asthma in patients with mild persistent asthma.


Eligibility criteria:
inclusion criteria: * patient is male or female, 6-14 years of age with mild persistent asthma * patient has a history of the following symptoms: wheezing, chest tightness, cough, etc. * patient has asthma diagnosed by a doctor exclusion criteria: * patient is hospitalized * patient has had major surgery or participated in another clinical trial in the last 4 weeks * patient has been on a breathing tube for asthma
effects of physical activity on cardiovascular risk markers in school-aged mexican children

Conditions: Obesity; Cardiovascular Disease

Summary: childhood obesity is a public health problem; in mexican children a high prevalence of cardiovascular risk factors are present. physical activity has been proposed as a strategy to reduce this risk. we conducted a pre-posttest intervention study of 214 school-aged mexican children (4th to 6th grade), to assess the effects of two physical activity routines with different duration and intensity (40 minute aerobic routine vs. 20 minute routine) on cardiovascular risk markers. physical activity routines were assigned randomly to two public schools in toluca, mexico (20 min: group 1 (n= 117), 40 min: group 2 (n=97)). the routines were implemented monday through friday for 12 weeks. nutrition assessment was done before and after the intervention and included anthropometric measurements (weight, height, body mass index, waist circumference and body composition), blood pressure and biochemical analysis (triglycerides, total cholesterol ldl-cholesterol, hdl-cholesterol, glucose and insulin). heart rate was monitored 3 times during the intervention to evaluate the routine´s intensity.


Eligibility criteria:
inclusion criteria: * all children from 4th to 6th grade, from 2 public urban schools in toluca, estado de méxico exclusion criteria: * if they have a chronic disease * if they can not do exercise * if they have low body mass index (bmi less than 5th percentile). * if they miss more than 20 sessions * if they decide that they did not want to participate any more.

Keywords: school-aged children obesity cardiovascular risk physical activity
sunitinib treatment on tissue sodium accumulation (tss2)

Conditions: Renal Cell Cancer Metastatic; Hypertension; Sodium Imbalance

Summary: here, it is investigated how sunitinib, a tyrosine kinase-inhibitor targeting vascular endothelial growth factor receptors, might influence sodium homeostasis in the skin and if this is related to a well-described treatment side-effect of sunitinib, hypertension.

tyrosine kinases-inhibitors targeting vascular endothelial growth factor (vegf)-receptors (rtkis) are increasingly used in oncology in several metastatic tumor types. these agents are featured by toxicities including hypertension. according to a new insight, sodium in response to a high dietary sodium intake, is accumulated in a hyperosmolar way in the interstitial compartment. in response to this high sodium concentration cells of the mononuclear phagocytic system (mps) are activated resulting in an increased production of vegf-c, activation of vegf type 3 receptors and formation of a lymphatic capillary network, involved in clearance of interstitial sodium. blockade of stimulation of vegf-c receptors or depletion of mps cells in rodents has been associated with salt-sensitive hypertension. sunitinib is an orally-active, multitarget rtki mainly used for the treatment of patients with metastatic renal cancer and imatinib-resistant gastrointestinal stromal tumors. sunitinib blocks all three vegf receptors subtypes, including vegf-receptor type 3. the investigators hypothesize that treatment of patients with sunitinib is associated with tissue sodium accumulation and this accumulation contributes to the rise in blood pressure. tissue sodium is measured by using a newly developed 23na magnetic resonance-imaging (mri) technique which allows a non-invasive and contrast agent-free sodium content measurement in the muscle and skin of the lower leg.

Eligibility criteria:
inclusion criteria: * age men \> 18 years * life-expectation \> 3 months * stable weight * blood pressure below 140/90 mmhg at baseline * estimated glomerular filtration rate \> 45 ml/min/1.73m2 * willingness to give written informed consent exclusion criteria: * heart failure * liver disease with ascites * nephrotic syndrome * gastrointestinal complaints, preventing normal daily food intake or diarrhea * any form of diabetes mellitus * known autoimmune diseases * acute or chronic infection * alcohol or substance abuse

Keywords: sunitinib tyrosine kinases-inhibitor sodium mri skin