Kornimate/medical-research-clean huggingface dataset:
a combination of akr1b10 and ca19-9 improves the diagnosis of pdac

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: the purpose of this study is to clarify the diagnostic significance of akr1b10 in patients with pancreatic ductal adenocarcinoma, and to combine with ca19-9 to improve the diagnosis rate of pancreatic ductal adenocarcinoma.


Eligibility criteria:
general inclusion criteria 1. age ≥ 18 years old; 2. sign the informed consent form voluntarily; 3. not a patient in the intensive care unit; 2. patients with pancreatic ductal adenocarcinoma (pdac group) 1. two or more imaging studies (ultrasound, ct, mri) found pancreatic tumors before operation, after surgical resection, intraoperative frozen pathology and postoperative pathology were clearly diagnosed as pdac by 2 experienced pathologists, or diagnosed as pancreatic ductal adenocarcinoma by preoperative needle biopsy； 2. no other treatments such as radiotherapy or chemotherapy have been taken before the operation. 3. benign disease group (benign group) 1. diagnosis of pancreatic intraductal papillary mucinous tumor (ipmn), mucinous cystadenoma or pancreas cyst based on clinical manifestations, clinical examinations, medical imagings (ultrasound/ct/mri/ercp), biopsy, and pathology 2. no relevant surgical treatment; 4. healthy donors (healthy group) 1. healthy donors undergoing medical examinations at the above research centers; 2. healthy donors of similar age without any benign or malignant diseases. exclusion criteria: 1. pdac group: 1. patients who have undergone radiotherapy, chemotherapy and other tumor-related treatments before surgery; 2. patients with non-primary pancreatic cancer; 3. patients undergoing secondary operations; 4. infected with hiv or aids related diseases; 5. diagnosed as chronic or acute gastroenteritis; 6. pregnant women; 7. other situations that are not suitable for this research; 2. benign group (1) patients who have undergone related surgical treatment in other hospitals; (2) patients with a history of malignant tumors; 3. healthy group: 1. patients with a history of tumor; 2. tumors found in medical examinations; 3. history of hepatitis b or c; 4. a history of acute or chronic gastroenteritis, cholecystitis, and cholangitis.

Keywords: pancreatic ductal adenocarcinoma ca199 akr1b10
the effect of antecedent hypoglycaemia on β2-adrenergic sensitivity

Conditions: Diabetes; Hypoglycemia Unawareness

Summary: hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration. the loss of autonomic symptoms to hypoglycemia does not solely depend on loss of adrenaline responses.differences in sensitivity to catecholamines may also be involved. reconciling the data on β2-adrenergic receptor polymorphism to those on loss of β-adrenergic sensitivity in diabetic patients with hypoglycemia unawareness, we hypothesize that hypoglycemia unawareness is at least partly the result of desensitization of the β2-adrenergic receptor and that patients who are homozygous for arginine at codon 16 are particularly susceptible for this desensitization process, whereas patients who are homozygous for glycine at codon 16 are resistant for desensitization. objectives 1. to determine whether, and if so to what extent, antecedent hypoglycemia reduces β2-adrenergic sensitivity in healthy subjects with arg16 homozygosity. 2. to investigate whether or not healthy subjects with gly16 homozygosity are resistant to desensitization 3. to confirm that antecedent hypoglycemia reduces the heart rate response to isoproterenol and to assess to what extent this reduced response is mediated by impairments in baroreflex sensitivity.


Eligibility criteria:
inclusion criteria: * informed consent * homozygous for arginine at codon 16 or homozygous gly at codon 16 * no regular usage of medication other than oral contraceptives exclusion criteria: * history of cerebrovascular, cardiovascular, or peripheral vascular disease * smoking * alcohol usage of more than 10 units per week * inability to abstain from xanthine-derivatives (coffee, tea, cola, chocolate, cacao) or alcohol for 2 days * bmi above 30 kg/m2 * participation to any other trial in the preceding 3 months * ongoing disease of any kind * pregnancy

Keywords: hypoglycemia unawareness diabetes adrenal receptor adrenerg respons adrenergic beta-agonists salbutamol
study on the application of intraoperative optical coherence tomography technique in the diagnosis and treatment of lens diseases

Conditions: Lens Diseases

Summary: accurately assessing and dealing with anterior segment changes in the eyes of patients with lens diseases can better guide the operation details during surgery and make reasonable plans for possible intraoperative and postoperative complications. applying the intraoperative optical coherence tomography technique, this study analyzes the correlation between preoperative, intraoperative anterior segment structural changes and postoperative surgical effects in patients with lens diseases, and evaluates the clinical benefits of intraoperative optical coherence tomography technique in lens surgery. this study is intended to further improve the diagnosis and treatment quality of clinical lens diseases.

in the eyes of patients with lens diseases, there are often some special anterior segment changes, including ectopia lentis, abnormal lens morphology, and rupture of the lens capsule. these changes can be caused by ocular trauma, congenital anomalies, or be secondary to other ocular diseases and systemic diseases. accurately assessing and dealing with these anterior segment changes can better guide the operation details during surgery and make reasonable plans for possible intraoperative and postoperative complications. this study is based on intraoperative optical coherence tomography technique, analyzes the correlation between preoperative, intraoperative anterior segment structural changes and postoperative surgical effects in patients with lens diseases, and evaluates the clinical benefits of intraoperative optical coherence tomography technique in lens surgery. this study is intended to further improve the diagnosis and treatment quality of clinical lens diseases.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years old, with lens opacity or abnormal position, and other conditions meeting the surgical indications, needing lens surgery treatment, with or without anterior segment structural changes. exclusion criteria: * combined with other eye diseases that seriously affect visual prognosis, serious systemic diseases and other conventional contraindications for lens surgery.
a study of the pharmacokinetics and immunologic effects of lipoic acid in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to learn about an investigational drug known as oral lipoic acid (la) that may help treat multiple sclerosis. this study will measure how a person's body absorbs and breaks down the drug (pharmacokinetics) and will compare four different forms of the drug from four different manufacturers as well as la in conjunction with fish oil.

multiple sclerosis (ms) is a common, often disabling inflammatory disease of the central nervous system (cns). present treatments for ms are only partially effective, available only in injectable forms, have significant side effects and are very costly. developing more effective and better-tolerated treatments of ms thus remains an important goal for the improvement of the care of ms. lipoic acid (la) is an antioxidant that is widely available as a dietary supplement. the primary outcome of this study is to determine the pharmacokinetics of oral la 1200 mg to see if we can identify factors affecting the bioavailability of la. we will also study the salivary concentrations of oral la and its correlation with the serum la concentrations. we will also study the effects of la on the immunological markers after four hours of administration.

Eligibility criteria:
inclusion criteria: * definite ms by mcdonald's or poser's criteria * edss ≤ 7.5 * age 18 to 80 exclusion criteria: * no clinically significant ms exacerbation within 30 days of the screening * no systemically administered corticosteroids within 30 days of study entry * patient not pregnant or breast feeding * no la in previous 2 weeks * not on anti-coagulants such as heparin, coumadin, or aspirin during study * no other significant health problem (e.g. active coronary heart disease, liver disease, pulmonary disease, diabetes mellitus) that might increase risk of patient experiencing adverse events * inability to give informed consent * any condition which would make the patient, in the opinion of the investigator, unsuitable for the study

Keywords: multiple sclerosis lipoic acid la pharmacokinetics immunological effects
effects of scapular strength exercise for patients with lateral epicondylalgia

Conditions: Lateral Epicondylitis

Summary: the aim of the study is to determine whether a scapular strength exercise program combined with a conventional exercise program in epicondylar region in patients with lateral epicondylalgia produces statistically significant improvements in pain in the short and medium term compared to a conventional exercise program.

it is a single-blind clinical trial design, with third-party evaluation. there are two groups, the control group and the experimental group. in the control group, only the conventional exercise program for epicondylar muscles will be performed and the experimental group will also perform a scapular exercise program. group assignment is randomized using the g\* power software program, following the inclusion and exclusion criteria. variables related to pain, functionality, pressure pain threshold, prehensile strength and quality of life will be measured. the study will last 7 months.

Eligibility criteria:
inclusion criteria: * tenderness over the epicondyle. * clinical diagnosis of ld for at least 3 months. * positive mills and maudsley test exclusion criteria: * patients with carpal tunnel syndrome, rheumatoid arthritis, cervical root syndrome, rotator cuff tendinopathy. * fractures or surgical history in the shoulder or elbow. * history of elbow immobilization. * limitation in range of motion of the shoulder. * having undergone upper limb surgery in the last 6 months * unhealed wound in the region in the treatment area * impairment at a cognitive level that makes understanding with the therapist impossible. * neural entrapment of the radial nerve. * corticosteroid infiltration in the upper limb to be treated.

Keywords: lateral epicondylalgia tennis elbow lateral epicondylitis exercise scapular muscle
determination of risk factors of postpartum urinary retention

Conditions: Postpartum Acute Urinary Retention

Summary: postpartum urinary retention is an uncommon complication of the vaginal delivery. failure to diagnose it may have a real impact both on the urinary plane but also on the psychological level. the hypothesis is that the identification of risk factors for the emergence of acute urinary retention would allow preventive management. the investigator conducted a retrospective, comparative, case-control study, including 2 groups of 96 patients who have had a vaginal delivery in the department between 2011 and 2015. the first group included patients with postpartum acute urinary retention (paur). the second group, control group, without paur, was selected randomly, respecting a 1:1 matching criteria, including the year of delivery and the age of the patient at delivery. the goal was to identify the potential risk factors of post-partum acute urinary retention in order to define a better prevention.


Eligibility criteria:
inclusion criteria: * vaginal delivery * between 2011 and 2015 * postpartum acute urinary retention for the first group / without postpartum acute urinary retention for the second group exclusion criteria: * caesarean section
post covid-19 dysautonomia rehabilitation randomized controlled trial

Conditions: Post-Acute COVID-19 Syndrome; Dysautonomia

Summary: dysautonomia in post-covid-19 condition appears to affect a significant number of patients, with reports raising the incidence up to 61%, having an overlap with myalgic encephalomyelitis/ chronic fatigue syndrome. quality of life and daily function is significantly impacted and conservative management interventions, despite the lack of high quality evidence up to now, are needed to ameliorate disability. 50 adults with a dysautonomia post-covid-19 diagnosis based on the ewing battery and a nasa lean test will be enrolled in a randomized single blinded controlled trial with a crossover design. feasibility and lack of definite dysautonomia diagnosis will be the primary out-comes, while secondary outcomes will be health-related, clinical and cardiopulmonary exercise test indicators. safety and acceptance will also be checked, primarily excluding participants with post exertional malaise. the long-covid patients causal diagnosis and rehabilitation study in patients with dysautonomia (locodire-dys) study intervention will consist of an educational module, breathing retraining and an individualized exercise intervention of biweekly sessions for two months with regular assessment of both groups. locodire- dys aims to be the first post-covid-19 randomized study in people with dysautonomia offering a multimodal intervention both in diagnosis and management


Eligibility criteria:
inclusion criteria: * adults 18-65 years of age * who definition of post covid-19 condition * confirmed dysautonomia diagnosis through ewing battery * able to attend 2 times/ week for 8 weeks * able to provide informed consent exclusion criteria: * absolute or relative contra-indications to exercise due to cardiac pathology * serious mental/ cognitive impairment that will not allow systematic participation * unable to regularly reach the center * pregnancy * cfs/me fulfilling the canadian consensus criteria * secondary health conditions that would explain symptoms, intervene in dysautonomia diagnosis or would impede participation in the exercise protocol (i.e. , untreated hypothyroidism and diabetes melitus, major psychiatric disorders, copd, pics, pulmonary fibrosis, chronic respiratory or heart failure, not ambulatory, suffering from dementia, chronically paralyzed, with paraplegia, with multiple injuries or other serious orthopedic problems that caused disability, patients suffering from very serious underlying diseases such as end-stage cancer, and those with neurological diseases causing disability)

Keywords: long covid post covid-19 condition rehabilitation
use of botulinum toxin a in direct eyebrow lift scar

Conditions: Skin Scarring; Eyebrow Ptosis

Summary: prospective, controlled and randomized study in which participants indicated for surgery to direct eyebrow lift will be randomized into two groups. in addition to surgery, the patients will be treated with botulinum toxin in one eyebrow and saline (placebo) in the other site. the patients participate as treatment and placebo at the same time. assessments will be carried out through non-invasive exams.

a component of eyebrow ptosis, part of the natural aging process, with or without asymmetries, is found in the majority of patients who seek the blepharoplasty procedure. there are several procedures to address this condition, but none of them is undoubtedly superior to the others. the direct eyebrow lift technique is known for providing good eyebrow suspension, predictable results and relatively low complexity surgery, which can be performed with local anesthesia. however, the biggest concern for surgeons and patients is the final appearance of the scar, which will be in a visible area of the face. botulinum toxin a has been used in recent studies precisely to improve the appearance of scars. previous studies mainly evaluated traumatic lacerations and post-tumor excision reconstructions, obtaining positive results, with an improvement in the appearance of the wounds in patients who used the medication. it is a safe drug, used for several years for other purposes and without serious adverse effects according to these studies. the objective of this study is to compare the use of botulinum toxin a versus 0.9% saline solution in the healing of direct eyebrow lift surgery.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with indication for direct eyebrow lift surgery. exclusion criteria: * vulnerable groups: children, pregnant women and immunosuppressed patients * allergy to botulinum toxin a * patients under 18 years old * women who are breastfeeding * patients with muscular/neuromuscular diseases such as myasthenia gravis and amyotrophic lateral sclerosis * patients who underwent botulinum toxin a injection in the last 6 months prior to surgery * patients with a history of radiotherapy, chemotherapy or hematological disorders * refusal to participate in the study

Keywords: botulinum toxin a direct eyebrow lift eyebrow scar
effect of a monthly high dose of vitamin d3 on bariatric surgery patients

Conditions: Morbid Obesity; Vitamin D Deficiency

Summary: bariatric surgery patients tend to have malabsorption of many micronutrients such as b12, iron and vitamin d postoperative. so in this study, a monthly high dose of vitamin d3 is giving to patients with their routine supplements and followed up for 6 months. hypothesis:bariatric surgery subjects taking monthly high dose cholecalciferol supplements in addition to the standard vitamin d protocol will have a significant rise in serum vitamin d levels compared to the subjects taking only the usual vitamin d protocol.

sun exposure and supplement use questionnaire: a registered dietitian asked each subject for information on sun exposure, vitamins, medications, and any other supplement usage before each blood sample was taken. lab analysis included serum hydroxy vitamin d levels pre and 3 months postoperative. descriptive statistics which include both the means and standard deviations were calculated on the study variables. a paired sample t-test was used to determine if there was a significant difference in mean values pre and post vitamin d supplementation. an independent sample t-test was used to assess for significant differences in group (control vs. vitamin d supplement) means. a p-value \< 0.05 was considered statistically significant. statistical analyses were done using spss version 21 (spss, chicago, iii, usa).

Eligibility criteria:
inclusion criteria: * morbidly obese and eligible for bariatric surgery exclusion criteria: * under 18 and over 60 years of age * elevated serum vitamin d and calcium * pregnant and lactating women

Keywords: vitamin d obesity bariatric surgery
intestinal permeability and gastroparesis

Conditions: Gastroparesis; Healthy

Summary: the purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.


Eligibility criteria:
inclusion criteria: * adult patients (18-75 years old). * men and women. * patients with gastroparesis. exclusion criteria: * patients will be excluded from the study if symptoms are thought to represent an organic disorder (e.g., peptic ulcer disease, hepatitis, pancreatitis, inflammatory bowel disease, a known malignancy, radiation-induced injury, an active infection, vasculitis, celiac disease), gerd, esophagitis, eosinophilic esophagitis or h. pylori. * patients with uncontrolled diabetes mellitus (hemoglobin a1c \> 10). * patients with prior surgery to the esophagus, stomach or duodenum. * patients taking opioids, steroids, anti-histamines, immunosuppressive agents, nsaids, or mast cell stabilizing agents within the prior 3 months. * patients currently prescribed aspirin or aspirin regimens for other clinical reasons. * patients with known allergies to lactulose: mannitol will be excluded.
to evaluate immunogenicity, reactogenicity & safety of 2 doses of gsk bio hrv liquid vaccine given to infants (vietnam)

Conditions: Infections, Rotavirus

Summary: to provide specific data on immunogenicity of gsk biologicals' hrv liquid vaccine, when co-administered with the routine expanded program of immunization (epi) in vietnam. the study will also assess reactogenicity and safety of the hrv liquid vaccine relative to the placebo


Eligibility criteria:
inclusion criteria: * healthy male or female infant between, and including, 6 and 10 weeks of age with a birth weight of \> 2000 grams. * written informed consent obtained from the parent or guardian of the subject. exclusion criteria: * use of any investigational or non-registered product (drug or vaccine) other than the hrv liquid vaccine or placebo within 30 days preceding the first dose of hrv liquid vaccine or placebo, or planned use during the study period. * chronic administration of immunosuppressants or other immune-modifying drugs since birth. * planned administration/ administration of a vaccines not foreseen by the study protocol except for dtpw, hbv and opv vaccines within 14 days before each dose of hrv liquid vaccine or placebo and ending 14 days after. * concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product (pharmaceutical product or device). * history of allergic disease or reactions likely to be exacerbated by any component of the hrv liquid vaccine or placebo.

Keywords: prophylaxis against gastroenteritis caused by rotavirus
randomized controlled trial of a self-help book for insomnia in patients with co-morbid osa and insomnia

Conditions: Sleep Apnea; Insomnia

Summary: obstructive sleep apnea (osa) is a common sleep disorder treated with continuous positive airway pressure (cpap). some osa patients also suffer from co-morbid insomnia. cpap treatment may be complicated in patients with co-morbid insomnia. this project evaluates the effects of a self-help book for insomnia in patients being treated with cpap for osa.

this study is a randomized controlled trial evaluating the effect of a self-help book for insomnia in patients with obstructive sleep apnea (osa) and co-morbid insomnia. 180 patients are randomized to either receive the self-help book (90 patients) or sleep hygiene advice (90 patients). patients fill out questionnaires about sleep and health both at baseline and after three months. furthermore, cpap compliance and osa severity will be evaluated after three months of cpap use. the aim is to evaluate whether the self-help book will improve sleep parameters and cpap compliance.

Eligibility criteria:
inclusion criteria: * patients diagnosed with osa and scheduled for cpap treatment. * having co-morbid insomnia. exclusion criteria: * less than 18 years of age * not fluent in norwegian
effects of lingzhi on disease progression in patients with untreated early parkinson's disease

Conditions: Parkinson Disease

Summary: lingzhi(ganoderma) is widely used in traditional chinese medicine. previous studies indicated that lingzhi was safe, well tolorated, and improved symptoms as an add-on therapy to levodopa in early parkinson's disease(pd) patients. here the investigators design a multicenter, randomized, double-blind, placebo-controlled, delayed-start trial to evaluate the effects of lingzhi on modifying disease progression in untreated pd patients.


Eligibility criteria:
inclusion criteria: * meeting the criteria for "probable parkinson's disease" according to 2015 mds clinical diagnostic criteria for parkinson's disease * aged 30-80 years * hoehn-yahr stage≤2 * updrs part iii subscores ranging from 10 to 30 points * disease duration of 5 years or less * untreated with antiparkinsonian drugs for at least two weeks preceding the trial * willing to sign the written informed consent exclusion criteria: * atypical or secondary parkinsonism * with psychiatric symptoms or a history of psychiatric diseases * with cognitive impairment(mmse score\<24) * major liver or kidney dysfunction * participating in other clinical trials within 3 months preceding the current trial

Keywords: parkinson's disease lingzhi traditional chinese medicine