Kornimate/medical-research-clean huggingface dataset:
relation between covid-19 pts and hyponatremia in adreno ortical insufficient patients.

Conditions: COVID-19

Summary: hyponatremia in covid-19 patients with adrenal insufficiency

hyponatremia is the most prevalent hydroelectrolytic disorder in clinical practice, and is linked to higher rates of morbidity and mortality. 1, 2.sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with covid-19 . and it is associated with a higher risk of morbidity, mortality, and disability. acute hyponatremia causes serious brain swelling that can lead to permanent disability or death. chronic hyponatremia causes attention deficit, gait instability, and osteoporosis, mechanisms of hyponatremia in coronavirus disease 2019 (covid-19) patients. osmotic syndrome of inappropriate antidiuretic hormone release (siadh) as a major mechanism. also hypovolemic hyponatremia that may have been common in covid-19 patients since nausea, vomiting, diarrhea.we predict critical illness-related corticosteroid insufficiency (circi) play a role in hyponatremia in covid-19 , high percentage of critically ill patients with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection in the study were treated with vasopressors (2). angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 serine protease were colocalized in adrenocortical cells in the zona fasciculata and zona reticularis (2). plasma cortisol concentrations will be collected in critically ill patients with covid-19 (2). the cortisol levels of critically ill patients with covid-19 were low(2).we aimed to identify the previlence and mortality rate of hyponatremia in covid 19 patient with adrenal insufficiency . our studies will present in assiut hospital university on patients in isolation ward from october 2021 to october 2022.

Eligibility criteria:
inclusion criteria: * 1-suspected covid-19 patients come to isolation hospital in assuit. 2-hyponatremia. 3- adrenal insufficiency exclusion criteria: * non-cooperative patients

Keywords: hyponatremia
a phase i trial using suramin to treat superficial transitional cell carcinoma of the bladder

Conditions: Bladder Neoplasms; Carcinoma, Transitional Cell

Summary: patients with superficial transitional cell carcinoma of the bladder will be treated with intravesical suramin in a phase i dose escalating study. the toxicity of suramin administered in this fashion will be evaluated.

patients with superficial transitional cell carcinoma of the bladder will be treated with intravesical suramin in a phase i dose escalating study. the toxicity of suramin administered in this fashion will be evaluated.

Eligibility criteria:
disease characteristics: histologically confirmed superficial transitional cell carcinoma of the bladder pathologically staged as tis, ta, or t1. visible tumors at time of treatment not required. no metastatic disease or muscle invasion. clinically useful pretreatment bladder function required. no significant prostatic obstructive symptoms associated with impaired or incomplete bladder emptying. no active urinary tract infection. prior/concurrent therapy: at least 1 course of prior standard intravesical therapy required. at least 4 weeks since intravesical treatment, with resolution of any local or systemic toxicity. patient characteristics: age: 18 and over. performance status: ecog 0 or 1. hematopoietic: wbc at least 3,300; hemoglobin at least 10 g/dl. hepatic: bilirubin no greater than 1.5 mg/dl; ast and alt no greater than 2 times normal. renal: creatinine no greater than 1.5 mg/dl. other: medically able to undergo cystoscopy. no pregnant women.

Keywords: adult intravesical chemotherapy
predicting central pain among people with a spinal cord injury by evaluating mechanisms regulating pain and efficacy testing of the tens apparatus

Conditions: Pain; Healthy

Summary: people with a spinal cord injury can develop chronic pain within months of the injury. up to 80% of the patients will develop chronic pain called "central pain" and describe the pain as: burning, stabbing, or "like electricity." central pain mechanism is unknown and therefore treatment is currently not effective. it is hypothesized that chronic pain is associated with impaired function of the systems regulating pain, however, this hypothesis has not been tested among spinal cord injury patients. presence of such a connection, between the regulating system dysfunction and central pain, will help both predicting the risk of central pain and develop a treatment. the current research objective is to make several sensory measurements which will measure the functioning mechanisms of regulation and control of the pain. these measurements are accepted throughout the world and are based on psychophysical assessment of patients. these measurements are designed to assess whether spinal cord injury chronic central pain patients demonstrate impairment in the regulation of pain. finding such a link between central pain and impaired regulation could shed light on the mechanism of central pain. in addition, these measurements are designed to assess whether fresh spinal cord injury patients that have not yet developed central pain demonstrate impairment in the regulation of pain immediately after the injury. by repeated assessments of pain regulation capabilities, which will be made to fresh spinal cord injury patients during the first months of injury, and comparing the results of these measurements between those who will develop center pain and those who will not, we could identify indicators for predicting the risk of central pain. another goal of the study is to investigate the efficacy of central pain treatment, using a tens, when the parameters of the tens treatment will be built according to the level of functioning of the regulating systems of the individual.


Eligibility criteria:
inclusion criteria: * for all subjects: * age - 18-70 * cognitive status that allows voluntary cooperation understanding of instruction * for chronic spinal cord injury subjects: * spinal cord injury (complete and incomplete) * height of injury - under 7th cervical vertebra * time since injury - one year or more. * for chronic spinal cord injury subjects: * spinal cord injury (complete and incomplete) * height of injury - under under 7th cervical vertebra * time since injury - three weeks or less exclusion criteria: * subjects suffering from the following conditions: pacemaker,pregnancy,cancer, tuberculosis, thrombosis, metallic implants * systemic diseases that affect the sensory perception (such as diabetes) * patients with other neurological pathologies (such as head injury-tbi) * pregnancy

Keywords: chronic spinal cord injury patients
combination chemotherapy in treating patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic colorectal cancer.

objectives: * determine the response rate of patients with metastatic colorectal carcinoma treated with o6-benzylguanine and carmustine. * evaluate tumor tissue biochemical and immunohistochemical predictors of response in patients treated with this regimen. * correlate carcinoembryonic antigen levels in the peripheral blood with response in patients treated with this regimen. outline: this is a multicenter study. patients receive o6-benzylguanine (bg) iv over 1 hour and carmustine iv over 1 hour (beginning 1 hour after completion of bg infusion) on day 1. treatment continues every 6 weeks in the absence of disease progression or unacceptable toxicity. patients are followed every 3 months. projected accrual: a total of 19-36 patients will be accrued for this study within 1.7-3 years.

Eligibility criteria:
disease characteristics: * diagnosis of metastatic colorectal carcinoma * bidimensionally measurable disease patient characteristics: age: * 18 and over performance status: * ecog 0-2 life expectancy: * at least 12 weeks hematopoietic: * wbc at least 4,000/mm\^3 * granulocyte count at least 1,500/mm\^3 * absolute neutrophil count at least 1,500/mm\^3 * platelet count at least 100,000/mm\^3 * hemoglobin greater than 8 g/dl hepatic: * bilirubin no greater than 1.2 mg/dl * ast and alt less than 2.5 times upper limit of normal (uln) * pt no greater than uln (not on anticoagulation therapy) renal: * creatinine no greater than 1.5 mg/dl * creatine clearance greater than 60 ml/min pulmonary: * dlco at least 60% other: * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception during and for 2 months after study * no other concurrent active malignancies * prior malignancies presumed to be cured allowed * no other concurrent uncontrolled severe medical problem that would preclude study participation prior concurrent therapy: biologic therapy: * not specified chemotherapy: * at least 6 months since prior adjuvant chemotherapy without disease recurrence * no more than 1 prior chemotherapy regimen for metastatic disease endocrine therapy: * not specified radiotherapy: * prior adjuvant radiotherapy allowed * no prior radiotherapy to more than 25% of total bone marrow surgery: * not specified other: * no other prior therapy for advanced disease

Keywords: stage iv colon cancer stage iv rectal cancer recurrent colon cancer recurrent rectal cancer
prognostic factors for ablation of atrial fibrillation

Conditions: Atrial Fibrillation; Catheter Ablation; Spectral Analysis; Vectorcardiography; Heart Rate Variability

Summary: the aim of the study is to find factors associated with sinus rhythm maintenance after catheter ablation for atrial fibrillation.

catheter ablation presents the most effective kind of treatment for atrial fibrillation (af). however, its efficacy is still limited, and af reoccurs in approx. 30% of patients during the first year after ablation. several factors associated with af recurrences were found, such as dilated left atrium, higher age, or the duration of af before the ablation. as it was shown, the detailed analysis of the ecg before the ablation could also serve several important factors that could predict af reoccurrence. in the study, all participants who will be referred for af ablation in the study center will be enrolled. pre-procedural ecg on the day of the ablation (just during the procedure) will be analysed using several methods: 1) spectral analysis (dominant af frequency will be determined), 2) heart rate variability (for time and frequency domain analysis), 3) vectorcardiography. all ecg recordings will be analyzed using matlab software. all participants will have regular follow-up checks at 3, 6, and 12 months after ablation including 24-hour holter recordings. based on the rhythm presence during the follow-up, participants will be divided in two groups: 1) af group (patients with af recurrences) and 2) sinus rhythm (sr) group (patients without af reoccurrence during follow-up). af reoccurrence will be determined at a presence of af or any other atrial tachycardia lasting \> 30 sec. the results of pre-procedural ecg analysis will be compared between both groups. logistic regression will be done to determine optimal combination of parameters associated with af freedom.

Eligibility criteria:
inclusion criteria: * atrial fibrillation exclusion criteria: * absent of informed content
detecting and addressing preclinical disability

Conditions: Back Pain; Coronary Artery Disease; Chronic Obstructive Pulmonary Disease; Diabetes; Hypertension; Multiple Sclerosis; Osteoporosis; Osteoarthritis; Rheumatoid Arthritis; Stroke

Summary: the physical functioning inventory (pfi) is a standardized patient reported outcome measure that assesses preclinical disability. preclinical disability is a functional state in which people are still able to complete daily living tasks (e.g., walking, bathing) but are changing the frequency or modifying the way that they complete the tasks. the investigators have done some preliminary research using the pfi as an online monitoring tool (richardson 2012), but further study is required to examine its psychometric properties and its suitability for use as a primary outcome measure. this measurement study has been designed to identify the optimal number of items on the pfi and to determine the reliability, validity, and responsiveness of the pfi when administered to a sample of adults and older adults both with and without chronic conditions. this project will also allow us to evaluate the use of self-monitoring of physical function and the added value of rehabilitation professionals to support self-monitoring. using the results of the pfi, the investigators aim to develop a "tailored" population-based rehabilitation self-management intervention delivered through a secure messaging system in the patient's electronic personal health record (myoscar) that focuses on the early detection and prevention of preclinical disability.


Eligibility criteria:
inclusion criteria: * greater than or equal to 44 years of age * able to communicate in english * have had at least 3 physician visits in the last year * are able to access an email address independently * have a chronic disease exclusion criteria: * any evidence of cognitive impairment * unable to travel to the clinic * awaiting long-term care * planning to relocate * experiencing an acute illness * are receiving palliative care
a digital health intervention to improve symptoms and physical activity during breast radiation

Conditions: Anatomic Stage 0 Breast Cancer AJCC v8; Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Breast Carcinoma

Summary: this clinical trial evaluates a digital health intervention for improving symptoms and physical activity among patients with breast cancer undergoing radiation. cancer-related fatigue is common and strongly associated with quality of life during and after treatment. increasing emphasis on early symptom detection and management has prompted initiatives to collect patient-reported fatigue from all patients during treatment. mind-body interventions including physical activity and yoga are recommendations to treat fatigue and comorbid (coexisting) symptoms. lower socioeconomic status has not only been associated with higher rates of physical inactivity but also with perceptions that it could negatively impact fatigue and quality of life during treatment. a virtual mind-body program called integrative medicine at home (im@home) includes cardio fitness and yoga classes in a bundled intervention that has demonstrated decreased fatigue, depression, insomnia, and symptom distress among patients undergoing breast radiation. the im@home program may also increase physical activity among patients with breast cancer undergoing radiation.

outline: registry: patients receive a fitbit activity tracker and complete patient-reported outcomes (pro) surveys every 2 weeks (q2w) to monitor fatigue, comorbid symptoms, and physical activity during and immediately after radiation therapy. patients with presence of self-reported symptoms or physical inactivity at baseline and/or from any q2w pro surveys are then invited to participate and register for im@home. intervention: patients participate in the im@home program consisting of 20+ live, virtual mind-body and fitness classes ranging from yoga and tai chi to dance cardio, guided meditation, and music therapy delivered via zoom over 30-60 minutes. patients are instructed to complete at least 3 classes per week for 12 weeks.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old. * ability to understand english, or has a caregiver who understands english. * ability to understand and willingness to sign a written informed consent document, virtually or in-person. * current breast cancer diagnosis. * currently receiving radiation with curative intent (including partial breast, whole breast, or regional nodal radiation). exclusion criteria: * patients who are non-english speaking that would prevent their participation in im@home. * patients with metastatic disease (i.e. stage iv).
expression profiles of integrin αdβ2 on neutrophils in sepsis

Conditions: Sepsis

Summary: in this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. sepsis is a severe type of infection, affecting various parts of the body. neutrophils are a type of white blood cell that are part of the body's immune system. even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. neutrophils can change their character in sepsis. because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.


Eligibility criteria:
case inclusion criteria: * sepsis patient in the icu with a breathing tube control inclusion criteria: * scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure * plan to have endotracheal tube for planned procedures. exclusion criteria: * on chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)
a pilot dose ranging study of spinosad creme rinse

Conditions: Pediculosis Capitis; Head Lice

Summary: a pilot dose ranging study to evaluate the safety and efficacy of different strengths of spinosad creme versus a vehicle control.

a phase 2a, randomized, single investigational site, investigator/evaluator-blind, four-arm, parallel-group, vehicle-controlled, pilot study to evaluate the safety and efficacy of different strengths of spinosad creme rinse verses vehicle control.

Eligibility criteria:
inclusion criteria: * active head lice infestation * male or female, 2 years of age or older * good general health * appropriately signed informed consent * subject agreement to not use any other form of lice treatment during the course of the study * subject agreement to not cut or chemically treat their hair between visits exclusion criteria: * history of irritation or sensitivity to pediculicides or hair care products * individuals with any visible skin/scalp condition that would interfere with the evaluation * individuals previously treated with a pediculicide within 4 weeks prior to study enrollment * individuals using hair dyes, bleaches, permanent waves or relaxing solutions 2 weeks prior to study enrollment * individuals who have participated in any clinical trial within 30 days of enrollment * individuals with family members who were infested with lice but were unwilling or unable to enroll in the study or use a standard course of lice treatment * females who were pregnant or nursing * sexually active females not using effective contraception

Keywords: pediculosis capitis head lice
mitaorta - role of mitochondrial dynamic in aneurysm and dissection of ascending thoracic aorta

Conditions: Aortic Aneurysm and Dissection

Summary: the main objective is to compare the mitochondrial dynamic between patients operated for aneurysm of ascending aorta or type a aortic dissection (aad) or control group

in an aortic aneurysm process, the alteration of the extracellular matrix (ecm) as well as the apoptosis of the smooth muscle cells are due to inflammatory phenomena and oxydative stress, involving mitochondria which has a key place within cells. mitochondrial fusion and fission constitute mitochondrial dynamic and are involved in the mechanisms described above. the alteration of mitochondrial dynamics has been demonstrated in many pathologies, in particular neurological, cancer and cardiovascular disease and generally occurs in favor of fission. in a mouse model (faseb j, 2021, robert p ), the role of mitochondrial fusion has been demostrated as a protective factor against hypertension in resistance arteries and a deletion of opa1 (optic atrophy 1) fusion protein may lead to aneurysm until aortic dissection. the results of this experimental study suggest a role of the alteration of mitochondrial dynamic in the development of aneurysm and aortic dissection.

Eligibility criteria:
inclusion criteria: * aneurysm aortic group: patients treated for an aneurysm of the ascending thoracic aorta with surgical indication according to the esc guidelines (2014). * aortic dissection group: patients treated for type a acute aortic dissection or intramural hematoma of the ascending thoracic aorta in emergency. * control group: patients operated for aortic valve replacement (little aortic sample before closing aortotomy) or coronary artery bypass grafting which the use of a saphenous graft and the performance of a proximal anastomosis on the ascending aorta is planned exclusion criteria: * patients under 18 years old * other acute aortic syndromes (penetrating ulcers, iatrogenic or traumatic dissections) * patients treated for aortic valve replacement in the context of infective endocarditis * patients treated for emergency aortic valve replacement or coronary bypass surgery\*\* * pregnant, parturient and breastfeeding women * patients protected by an administrative or judicial measure (curatorship, guardianship) * patients receiving psychiatric care under duress * adults subject to a legal protection measure. * patients whose the samples planned for the study could not be taken; * patients in the control group whose tissue sampling will not be performed.

Keywords: extracellular matrix cell survival oxydative stress mitochondrial fusion metabolomic profiling of aortic aneurym metabolomic profilng of aortic dissection
working memory training for dysphoric students

Conditions: Depression

Summary: depression is associated with impairments in executive functions, including working memory (wm) which is needed to maintain and manipulate goal-relevant information. due to these wm impairments depressed individuals have difficulties inhibiting and shifting from irrelevant (negative) information and updating goal relevant information. this study explored whether training wm decreases these impairments and reduces clinical symptoms of depression, anxiety and rumination. sixty-one students with an elevated score on the bdi-ii, representing a dysphoric mood state, executed a working memory training (n = 34) or placebo training (n = 27). before and after training their depression, anxiety, rumination and working memory were assessed. furthermore, they executed a working memory task while their pupil dilation was measured to assess their fatigue. moreover, the investigators compared the dysphoric students with a healthy student population on all measures.


Eligibility criteria:
inclusion criteria: * bdi 10 of higher for dysphoric group * bdi 5 or lower for healthy control group

Keywords: depression anxiety working memory rumination cognitive training executive functioning