Kornimate/medical-research-clean huggingface dataset:
covid-19 vaccine hesitancy among nurses

Conditions: COVID-19; Vaccine Hesitancy; Vaccination; Nurses

Summary: the purpose of this study is to investigate the correlation of intention to receive covid-19 vaccine, recommendation behavior, and 5c psychological antecedents among nurses. the results can be used to assist suggestions in the health education provided by nurses on the topic of covid-19 pneumonia and its vaccination. the purpose of the study is also wants to build a basis for future research and public support in vaccine decision-making, as well as to enhance the promotion of vaccine policy and enhance the resilience of the whole population during the pandemic ear.

a cross-sectional study based on convenience samples. the investigators recruit nurses and the general public to respond to structured self-filling electronic questionnaires by using an electronic data collection system. the questionnaires include demographic data and vaccine hesitancy questions in a total of 35 items. convenience sampling was applied to estimate the sample size according to the number of nurses in each county. it is planned to collect a total of 4258 responses by the end of the study. the study instrument is the 5c psychological antecedents of vaccination, which includes confidence, complacency, constraints, calculation, and collective responsibility.

Eligibility criteria:
\[nurses\] inclusion criteria: * male and female participants must be ≥ 20 years at the time of informed consent. * male and female participants have verification of registered nurse license. exclusion criteria: * male and female participants be\>80 years at the time of informed consent. \[general publics\] inclusion criteria: * male and female participants must be ≥ 20 years at the time of informed consent. * male and female participants have reading abilities above the intermediate level. exclusion criteria: * male and female participants be\>80 years at the time of informed consent.
postoperative opioid use and pain scores in patients undergoing transforaminal lumbar interbody fusion

Conditions: Low Back Pain

Summary: the purpose of this project is to study the effects of preoperative followed by scheduled intravenous acetaminophen on pain control for 24 hours postoperatively after minimally invasive 1 or 2 level transforaminal lumbar interbody fusion.

the purpose of this project is to study the effects of preoperative followed by scheduled intravenous acetaminophen on pain control for 24 hours postoperatively after minimally invasive 1 or 2 level transforaminal lumbar interbody fusion. the advantages of intravenous acetaminophen are well known in the literature and its opioid-sparing effects have been documented in multiple surgical studies. multimodal regimens are now being advocated in the literature to decrease opioid use (8, 23). this is especially significant in spine surgery patients who often have chronic pain requiring long-term use of these habit-forming drugs as well as in patients who may not be able to tolerate opiods due to health status. to our knowledge there are no studies done in the u.s. on the opioid sparing and pain reducing effects of intravenous acetaminophen on patients undergoing elective minimally invasive 1 or 2 level transforaminal lumbar interbody fusion. investigating intravenous acetaminophen, particularly its pain reducing and opioid sparing effects, may give surgeons another medication for use in a multimodal approach to pain.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * being scheduled to have elective primary minimally invasive 1 or 2 level transforaminal lumbar laminectomy interbody fusion * asa i, ii, or iii * informed consent form signed exclusion criteria: * anyone weighing less than 50kg (as this would require a dosing change). * hypersensitivity or contraindication to intravenous acetaminophen or opioids * allergy to methocarbamol; morphine sulfate, sevoflourane, or fentanyl * impairment of liver function-- defined as the inability to receive intravenous acetaminophen without dose adjustment as determined by the investigator; or history of chronic liver disease defined as history of hepatitis of any kind as recorded in the patient's chart * mental retardation recorded as a diagnosis in the patient's chart * history of chronic pain (defined as currently receiving treatment from a specialist for pain) * history of pain recalcitrant to intravenous morphine * impaired kidney function (defined as creatinine \> 1.5) * anyone who is not a candidate for general anesthesia or any other portion of the investigator's standard of

Keywords: acetaminophen in transforaminal lumbar interbody fusion
smcs with lvh compared to hcm

Conditions: Syndromic and Metabolic Cardiomyopathy; Hypertrophic Cardiomyopathy (HCM)

Summary: the goal of this cohort study is to investigate the clinical characteristics of smcs and to explore the difference in cardiovascular outcomes in comparison to age-, sex-, and admission year-matched hcm patients. the main question it aims to answer is: * do patients with smcs have higher rates of cardiac outcomes? * what risk factors do smcs patients experience a poor prognosis?


Eligibility criteria:
inclusion criteria: * patients who were diagnosed smcs or hcm. gene testing and muscle biopsy were used to confirm the diagnosis of smcs. the diagnose of hcm was according to the 2024 esc guidelines of hcm but without evidence of smcs. * complete baseline data * accessible follow-up data exclusion criteria: * incomplete baseine data
exercise in adults with post-acute sequelae of sars-cov-2 (covid-19) infection study

Conditions: COVID-19

Summary: to examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with pasc.

conduct a randomized control trial with a wait-list control to examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with pasc. examine participant compliance (in-person attendance, online engagement) with the 8-week exercise training program including in-person exercise sessions, cognitive performance training, and virtual exercise sessions delivered via a mobile application. to determine if compliance with the 8-week exercise training program is associated with improvement in functional, cognitive, and emotional health outcomes. determine if there is a maintenance effect for individuals randomized into the 8-week exercise training program by comparing their outcomes at the end of the 8-week training exercise program to their outcomes at the end of their trial participation (16 weeks).

Eligibility criteria:
inclusion criteria: * 18-65 years of age * self-reported history of covid-19 diagnosis * self-reported ongoing symptoms of pasc \>4 weeks after initial infection exclusion criteria: * neuromotor, musculoskeletal, or rheumatoid disorders that are exacerbated by exercise or conditions preventing cooperation * covid-19 infection occurring \> 6 months prior to screening date * contraindications to symptom-limited maximal exercise testing * individuals without access to a device with ios (apple devices such as iphone, ipad, macbook, etc.) * patient-reported diagnosis of severe arterial hypertension * patient reported metabolic disease * patient reported uncontrolled asthma * inmates * pregnancy * patient reported supplemental o2 use * presence of beards * patient reported diagnosis of claustrophobia * non-english speaking
e-therapeutic program for obese adolescents

Conditions: Obesity

Summary: this study aims to: i. determine the e-therapeutic intervention program effectiveness compared with the standard treatment protocol, on both the behavioural change (treatment adherence and promotion of healthy lifestyles) and health impact (weight control and quality of life), based on a population of adolescents followed at paediatric obesity clinic (poc) of hospital de santa maria (hsm), lisbon (portugal). ii. evaluate the health profile, treatment adherence, lifestyle and impact of weight on quality of life of this population. iii. test the usability of an e-therapeutic platform for obese adolescents and their families.

information and communications technology (ict) have been identified as important tools, allowing for health gains and reducing costs. they have been associated with positive results in terms of efficiency, effectiveness, equity, accessibility and quality of the provided care/services (alcañiz et al., 2009; baulch et al., 2008; cottrell, 2005; grohol, 1999). the existence of accurate, reliable, structured and relevant information, available when and where is needed, enables professionals and consumers to make informed and timely decisions (high commissioner for health, 2010; organization for economic cooperation and development, 2010). this project was designed according to the national guidelines (direção-geral da saúde, 2005), and has the potential to become a relevant educational and intervention instrument. its content may be adapted to the needs and expectations of target groups. strategies as problem solving reinforced by the e-therapeutic programme may enable participants to overcome barriers to adherence and thereby enhance treatment-induced weight losses (murawski et al., 2009). moreover, this project will allow to: a) obtain relevant information about patients and their progress, enabling health professionals to interpret the inputs and send feedback in real time, b) tailor therapeutic strategies to individual responses, c) monitor individual progress. this study is designed as a randomized clinical trial. the experimental group will follow the standard treatment protocol and, additionally, receive free access to the e-therapeutic platform (next.step) for 24 weeks. the control group participants will follow the standard treatment protocol and join a waiting list for entering the next.step. based on the literature review and on the contribution of the nola pender's health promotion reference model (pender et al., 2010), investigators will look for empirical evidence for the general investigation hypothesis: treatment adherence, healthy lifestyles, quality of life and weight control of obese adolescents are positively influenced by this intervention program.

Eligibility criteria:
inclusion criteria: * patients from poc/hsm * aged between 12 and 18 years * bmi percentile ≥ 95th * internet access at least once a week exclusion criteria: * presence of severe psychopathology * inability to communicate in writing * pregnancy * having been proposed for bariatric surgery

Keywords: obesity overweight technology internet intervention adolescents
post market safety study and effectiveness with evolence in subjects with skin color types iv-vi

Conditions: Non Therapeutic Body Modification

Summary: approximately 165 subjects with fitzpatrick skin color types iv, v, and vi and a moderate to deep wrinkle between the corner of the nose and the corner of the mouth, will be treated with evolence® (an approved collagen filler) to smooth and flatten that wrinkle. they will be observed for 6 months to establish safety of the product as it relates to scarring and changes in skin pigment, and long term effectiveness.

this is an open-label, multi-center, prospective, postmarket study to assess the safety and effectiveness of evolence® (dp101) in subjects with fitzpatrick skin color types iv, v, and vi seeking correction of bilateral facial wrinkles and folds of the nasolabial area. the study will enroll and treat a total of 165 subjects with fitzpatrick skin color types iv, v and vi who have clinical evidence of moderate to deep bilateral wrinkles in the nasolabial area.

Eligibility criteria:
inclusion criteria: * \>18 years of age * moderate to deep wrinkle in the naso-labial fold * fitzpatrick skin type iv, v or vi exclusion criteria: * pregnant or nursing females * hx of allergies to related products * history of keloids, active skin disease, or previous augmentation of the treatment area
evaluation of efficacy of sameup in subjects with depression symptoms: a randomized study

Conditions: Depressive Symptoms

Summary: this study is planned to assess the efficacy of sameup versus placebo after six weeks of treatment in subjects characterized by depression symptoms according to icd-10 (international classification of diseases - 10th revision) diagnostic criteria and confirmed by mean of zung's self-rating depression scale.

depression is a common condition of low mood and aversion to activity that can affect a person's thoughts, behaviour, tendencies, feelings, and sense of well-being. several literature findings suggest that an oral combination of the two food supplements same (s-adenosyl-l-methionine) and probiotic lactobacillus plantarum might be favourable in relieving some of symptoms of depression, particularly in the mild to moderate forms of this condition. this double blind placebo controlled clinical study aims to evaluate this hypothesis. in particular, the primary objective is to assess, versus placebo, the efficacy of sameup in improving the overall symptomology of depression after 6 weeks of treatment. subjects with mild to moderate depression were identified according to icd-10 diagnostic criteria and confirmed by mean of zung's self-rating depression scale. sameup, the investigational food supplement, is an oral formulation (tablet) containing s-adenosyl methionine (same) 200 mg and lactobacillus plantarum heal9 1x109 cfu, already notified to the ministry of health as food supplement. placebo is an oral formulation of inert tablet. placebo and sameup are indistinguishable.

Eligibility criteria:
inclusion criteria: 1. written informed consent, personally signed and dated by the subject. 2. males and females, aging 18-60 years old (limits included). 3. diagnosis of mild to moderate recurrent depressive disorder according to the icd-10 / f33 criteria (world health organization, 2004). 4. subject who, having completed the z-sds depression questionnaire, has a raw score between 41 and 55 (including limits). 5. subject able to comprehend the full nature and purpose of the study, available to cooperate with the investigator and to comply with the requirements of the entire study. exclusion criteria: 1. pregnant or breast-feeding woman. 2. subject with one or more psychiatric disturbances, such as: alcoholism, substance abuse or dependency disorder, bipolar disorder, schizophrenia, or other personality disorder. 3. subject with known or potential hypersensitivity to any ingredient in the study product. 4. subject in treatment with psycholeptic drug, such as: antipsychotics, anxiolytics, hypnotics and sedatives. 5. subject who has taken during the 2 weeks prior to inclusion, who is currently taking or plans to take other orally administered food supplements except the study product. only multivitamins, salts and trace elements are accepted

Keywords: depression probiotic same lactobacillus plantarum 299v anxiety insomnia irritable bowel syndrome randomized controlled study
a study to assess the effect of exenatide treatment on mean 24-hour heart rate in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: this study will explore the effect of exenatide (given twice a day) versus placebo (given twice a day) treatment on change in mean 24-hour heart rate over a 12 week period of drug exposure in patients with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes. * treated with metformin and/or a thiazolidinedione. * hba1c between 6.5% and 9.5%, inclusive. * body mass index (bmi) \> 25 kg/m\^2 and \< 40 kg/m\^2. exclusion criteria: * have previously received exenatide or glucagon-like peptide-1 analogs. * have participated in an interventional medical, surgical, or pharmaceutical study (a study in which an experimental, drug, medical, or surgical treatment was given) within 30 days of screening. this criterion includes drugs that have not received regulatory approval for any indication at the time of study entry. * receiving beta blockers. * receiving treatment with a drug directly affecting gastrointestinal motility, including but not limited to reglan® (metoclopramide), propulsid® (cisapride), and chronic macrolide antibiotics. * have received treatment with systemic glucocorticoid therapy by oral, intravenous (iv), or intramuscular (im) route within 6 weeks of screening, or are regularly treated with potent, inhaled intranasal steroids that are known to have a high rate of systemic absorption or bronchodilators. * have been treated with drugs that promote weight loss (for example, adipex® \[phentermine\], acomplia® \[rimonabant\], xenical® \[orlistat\], meridia® \[sibutramine\], acutrim® \[phenylpropanolamine\], or similar over-the-counter medications) within 3 months of screening. * have been treated for longer than 2 weeks with any of the following excluded medications within 3 months prior to screening: \*insulin; \*alpha-glucosidase inhibitors (for example, glyset® \[miglitol\] or precose® \[acarbose\]); \*meglitinides (for example, prandin® \[repaglinide\] or starlix® \[nateglinide\]); \*sulfonylureas (for example, glucotrol® \[glipizide\] or micronase® \[glyburide\]); \*dipeptidyl peptidase iv (dpp-iv) inhibitors (for example, januvia™ \[sitagliptin\]) * have donated blood within 60 days of screening.

Keywords: exenatide byetta type 2 diabetes heart rate amylin lilly
effects of "music for the mind" on pre-operative anxiety in dentistry

Conditions: Dental Anxiety

Summary: to examine the pre-operative effect of music for the mind compared to some other styles of music in patients undergoing dental procedures.

120 patients were sequentially assigned to four groups of 30 subjects. the music groups received music for the mind, iranian traditional music and mozart music through headphone for ten minutes prior to dental procedures, and the control group received silence through headphone. anxiety score and pulse rate and blood pressure were measured before and after receiving music

Eligibility criteria:
inclusion criteria: * need for dental treatments exclusion criteria: * usage of anxiety drugs * usage of psychoactive drugs * emergency cases

Keywords: music dental anxiety "music for the mind" mozart iranian traditional music
joint consultation between a neurologist and a clinical psychologist

Conditions: Neurodegenerative Disorders

Summary: joint consultations appeared a few years ago in routine medical practice, but they are still not widely used and rarely evaluated. the primary purpose of the study is to evaluate the impact for the patient of the presence of a clinical psychologist during the joint consultation. the secondary purpose is to evaluate the impact for the patient and for the neurologist of the presence of a clinical psychologist during the joint consultation


Eligibility criteria:
inclusion criteria: * patient with a neurodegenerative and/or neurogenetic disease * adult patient exclusion criteria: * dementia * age \<18 years

Keywords: joint neurologist psychologist consultation neurodegenerative and/or neurogenetic disease
daily activity and gait analysis after viscosupplement injection among hip osteoarthritis patients

Conditions: Hip Osteoarthritis

Summary: the objective of this study is to assess the changes in daily physical activity and gait pattern, following a viscosupplement injection among a population who is suffering from hip osteoarthritis. a kinetic and kinematic gait analysis, an actigraph activity monitor, a functional timed-stair-test and two questionnaires (medical outcome study short-form36 (mos-sf36), hip disability and osteoarthritis outcome score (hoos)) about how the pathology affects the quality of life, will be use.


Eligibility criteria:
inclusion criteria: * from 45 years old to 65 years old * clinically symptomatic moderate or severe hip osteoarthritis (tönnis grade ii to iii) * capacity to keep steady upright position and walking during 15 minutes * body mass index \< 40kg/m2 exclusion criteria: * bilateral hip osteoarthritis * no broken hip or leg during the last 12 months * bone necrosis * rheumatoid arthritis, articular chondrocalcinosis, metabolic bone disease, psoriasis, gout, active infection * per os corticosteroid treatment * corticosteroid injection \< 3 months * viscosupplement injection \< 6 months * hypersensitivity to hyaluronic acid products * planed surgery during study duration * physical or mental disability to fill in questionnaires and/or to participate to follow-up
the effect of orthosis and exercise in pes planus

Conditions: Pes Planus

Summary: there is no definite evidence for the conservative treatment of pes planus. we want to verify the combination efficacy of orthosis and toe walking exercise for the treatment of pes planus.

observation cohort study we prescribe ucbl orthosis and teach toe walking exercise. and we will check standing foot radiography (ap/lateral) annually. and we will compare the changes of talometatarsal angle and calcaneal pitch angle.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with pes planus * calcaneal pitch angle \< 15 degree exclusion criteria: * peripheral neuropathy * infection * rheumatoid arthritis * operation history

Keywords: pes planus ucbl exercise
the effects of online single-session interventions on college student well-being

Conditions: Well-Being; Depressive Symptoms; Anxiety; Affect

Summary: this study seeks to investigate the effects of an online single-session intervention on college student mental health and well-being. undergraduate students from the university of pennsylvania and harvard will be randomized to a 30-minute single-session intervention or a study skills control group. students' depressive symptoms, anxiety symptoms, positive and negative affect, and subjective well-being will be assessed up to 12 weeks post-intervention.

the design of our study is a randomized control trial. after enrollment in the study, participants will randomly assigned to one of two conditions. in each condition, participants will be asked to complete an initial survey of mental health and well-being measures. following this survey, participants will complete either a well-being skills single-session intervention or control single-session intervention (study skills) depending on which condition they were assigned to. these single-session interventions educate the participant on their focal concept and teach them exercises to improve that skill. completing the single-session intervention will take approximately 20-30 minutes. after completing their single-session intervention, all participants will retake the measures of mental health and well-being presented to them at the beginning of the program. participants will also be asked to complete measures of intervention feasibility, acceptability and appropriateness at this time. following this initial intervention, participants will retake the measures of well-being and mental health at 2 weeks, 4 weeks, and 12 weeks after they completed the intervention. this will allow us to fulfill our first objective by determining how long single-session interventions improve undergraduate mental health and well-being.

Eligibility criteria:
inclusion criteria: * current undergraduate student at select universities * able to access the internet * can participate in follow-up surveys for three months post sign-up exclusion criteria: * unable to access the internet * will not be able to respond to the follow-up surveys post-intervention