Kornimate/medical-research-clean huggingface dataset:
biomarkers and risk factors for perioperative neurocognitive dysfunction in elderly patients

Conditions: Perioperative Neurocognitive Dysfunction

Summary: basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.


Eligibility criteria:
inclusion criteria: * age more than or equal to 65 years old * asa classification ⅰ\~ⅲ grade exclusion criteria: * history of previous craniocerebral surgery or craniocerebral trauma * inability to successfully complete preoperative psychological function tests * those who are severely deaf, speech impaired and otherwise unable to communicate.
laparoscopic extraperitoneal ( modified) burch colposuspension

Conditions: Stress Incontinence, Female

Summary: urinary incontinence is a very common problem in women and can be seen at any age. laparoscopic burch operation has been shown to be an effective, convenient and safe method in women with stress incontinence. laparoscopic burch operation is less invasive because it is advantageous in terms of hospitalization time, blood loss, pain and recovery time, but the disadvantage is the procedure time. modified extraperitoneal technique may be a good method for lowering the procedure time.

in the research; the pre- and postoperative urodynamics of patients who underwent laparoscopic extraperitoneal (modified) burch operation in the gynecology and obstetrics clinic of istanbul health sciences university gaziosmanpasa training and research hospital will be compared. surgical outcomes together with complications will also be assessed. in addition, the quality of life (sf36), which determines the quality of life of the patients related to the urinary system functions, and the urogenital distress inventory (udi - 6), incontinence impact questionnaire (iiq-7) questionnaires that determine the effects of urinary incontinence, will be assessed preoperatively and postoperative 6 months of the patients.

Eligibility criteria:
inclusion criteria: * having stress urinary incontinence exclusion criteria: * having any kind of urogynecological surgery history * having pelvic mass * having endometrial or myometrial pathology * having uterine prolapsus grater than grade 2 * benign obese
effects of perioperative transauricular vagus nerve electrical stimulation on pod, pocd and cpsp

Conditions: Postoperative Cognitive Dysfunction; Postoperative Delirium; Chronic Post Operative Pain

Summary: postoperative delirium (pod) and postoperative cognitive dysfunction (pocd) occur in 11-51% of patients after surgery, and its prevalence increases with age. the occurrence of delirium is associated with increased morbidity and mortality, prolonged hospital stay, worse functional recovery. orthopedic procedures and specifically joint replacements have been considered as a major risk for development of chronic postsurgical pain (cpsp). approximately 13-44% of patients will develop cpsp after knee or hip arthopioid abuseroplasty. cpsp may cause the discomfort, distress, disability and opioid abuse. mounting evidence has revealed that inflammation triggered by surgical trauma plays a key role in pod, pocd and cpsp. recent studies found that vagus nerve stimulation showed the suppression of inflammation. in this study, the effect of perioperative transauricular vagus nerve stimulation on the prognosis of patients undergoing arthroplasty will be investigated, providing potential solutions for the prevention and treatment of postoperative cognitive dysfunction, postoperative delirium and chronic postsurgical pain.

the investigators assessed pod by the confusion assessment method for the icu twice daily for 7 days after surgery. participants' cognitive function was assessed with neuropsychological battery tests. the tests included digit span (forward and backward), corsi block, paired associate verbal learning, digit symbol test, trail-making test and so on.the investigators make a cpsp diagnosis based on the 11th revision of the international classification of diseases.

Eligibility criteria:
inclusion criteria: * 50 to 80 years old. * asa grade i-ⅲ. * elective knee or hip replacement. exclusion criteria: * mini-mental state examination (mmse) score \< 23. * education years\<7. * peptic ulcer disease, serious cardiac-cerebral vascular disease. * neurological or psychiatric disorders. * history of drug and alcohol abuse. * hepatic and/or kidney dysfunction. * bmi\>35. * patients on antidepressants. * asa \>ⅲ.
ivermectin in treatment of covid 19 patients

Conditions: Covid19

Summary: as egypt suffered a lot during the pandemic of covid 19 with limited drug choices, many of the patients could not acheive viral clearence with the standard module of care teh idea of introduction of new medications in the treatment protocol of covid 19 managment. ivermectin had shown a promising results in vitro studies and in limited in vivo studies. this clinical trial may open a new hope for covid 19 patients as a new and cheap line of treatment

the study will compare the effect of ivermectin in comaprison and addition to the standard mode of care for the covid 19 patients

Eligibility criteria:
inclusion criteria: * asymptomatic mild cases and moderate cases proven to be infected by covid 19 by viral rna swap exclusion criteria: * contraindications for the drug: hypersensitivity. * any medications with possible drug interactions. * severe cases. * any malignant condition. * pregnant females. * breast feeding females. * any patient on the following medications: erdafitinib- lasmiditan- quinidine due to potential severe drug interaction.
exploring the effectiveness of unpowered negative pressure wound therapy

Conditions: Chronic Wound; Acute Wound

Summary: the aim of this study is to investigate the effectiveness of non-powered negative pressure wound therapy (npwt) on the healing of abdominal surgical wounds. it is designed as a randomized controlled trial with an experimental group (using npwt) and a control group (conventional wound care). the study aims to recruit 160 participants: 80 with acute wounds and 80 with chronic wounds. participants will be randomly assigned to either the experimental group (40 acute wounds, 40 chronic wounds) or the control group (40 acute wounds, 40 chronic wounds). the study will assess wound healing rates and speed, quality of life, self-perceived health status, pain levels, complications, and wound care costs using indicators. effectiveness will be analyzed using generalized estimating equations (gee). the study anticipates that results will contribute to evaluating the effects of non-powered npwt on wound healing, quality of life, pain, and cost-effectiveness in patients with acute and chronic wounds.


Eligibility criteria:
inclusion criteria: 1. patients with acute wounds (wound duration \<4 weeks) or chronic wounds (wound duration ≥4 weeks). 2. wound depth \<2 cm. 3. age ≥18 years. 4. patients who have been evaluated and approved for participation by their attending physician. exclusion criteria: 1. patients with unstable vital signs. 2. presence of ischemia in the wound or surrounding tissues. 3. fragile skin around the wound. 4. severe wound infection or necrotic tissue. 5. wound size \>10 × 20 cm.

Keywords: negative pressure wound therapy; wound care randomized controlled trial
low versus moderate-intensity aerobic training in post-discharge covid-19 subjects

Conditions: COVID-19; Aerobic Exercises; Elderly

Summary: the main purpose of this study is to compare the impact of low versus moderate-intensity aerobic training in post-covid 19 older subjects. on exercise adherence and changes in physical fitness, psychological status, and quality of life after a 10-week intervention.


Eligibility criteria:
inclusion criteria: * age range of 60 - 80 years with * diagnosis of post-covid-19 exclusion criteria: * • history of lower limb surgeries, fractures * cardiac problems * respiratory problems * neurological problems * systemic problems and any other contraindications for aerobic training
interest balance auto-immune population in patients with focal epilepsy of unknown cause, not structural, not genetics, newly diagnosed

Conditions: Epilepsy

Summary: the knowledge of encephalitis associated with antibodies targeting intracellular antigens, and neuronal surface antibody syndromes has expanded considerably in recent times. the primary purpose of the investigators protocole is to determine the incidence of anti-neuronal antibodies (blood and csf) in a population of patients suffering from focal epilepsy of unknown cause to guide the management of these patients. the investigators hypothesis is that dysimmune encephalitis is more common than is suggested by the current literature, and that sometimes forms of encephalitis dysimmune "at minimum" can be observed only in the form of focal epilepsy without further manifestation associated.


Eligibility criteria:
inclusion criteria: * male or female 18-65 years * presenting focal epilepsy on the following arguments * crisis with clinical symptoms indicating focal seizure * \& / or crisis or critical focal inter-recorded on eeg interpreted by a neurologist with expertise in the field of epilepsy. * having not yet received a csf analysis * from unknown cause: * no evidence of injury (excluding temporal or hyperintensity of hippocampal sclerosis) on brain mri with focus on regions of interest cuts. * no discharge or generalized photosensitivity recorded over an extended interpreted by a neurologist with expertise in the field of epilepsy video-eeg. * no argument for metabolic or neurodegenerative genetic epilepsy. * normal neurological examination. * epilepsy that started within a period of two years preceding the study entry (including vegetative symptoms of temporal focal seizures). * without treatment or as benzodiazepines or taking anti-epileptic first-line monotherapy (excluding benzodiazepines). * informed consent signed * affiliated with a social security scheme exclusion criteria: * structural abnormality found in brain mri (except temporal hyperintensity and / or sclerosis of the hippocampus). * background neurological: hyperthermic seizures in childhood, neonatal distress, history of seizures related to a circumstance, inflammation or infection of the cns. * taking toxic: chronic alcoholism, narcotic consumption * the case for a genetic / metabolic neurodeg ear /: generalized eeg / photosensitivity / family history of epilepsy / autism / disorder syndrome psychomotor development / dysmorphic syndrome / extrapyramidal syndrome associated discharge * history of thyroiditis or m. system (lead, sgs, pr, sarcoidosis) * immunosuppression innate or acquired * ic lumbar puncture or have already received a lumbar puncture before inclusion in the protocol. * person under supervision or guardianship.

Keywords: limbic encephalitis anti-neuronal antibodies
gut and oral microbiome of gdm patients during pregnancy

Conditions: Gestational Diabetes; Pregnancy Related

Summary: the study aimed to clarify the characteristics of the intestinal and oral microbiome of gestational diabetes mellitus(gdm) patients during the whole pregnancy, try to clarify the relationship between the microbiome and gdm.

the aims of the study are to reveal the possibly natural change of the gut and oral microbiome of gdm patients during pregnancy, and to explorer whether gdm happened during pregnancy are associated with the maternal gut and oral microbiomes. as a perspective cohort study, the researchers will recruit pregnant women in early pregnancy（before 13 gestational weeks）and following the pregnancies till delivery. the stool samples and saliva samples of the recruits will be collected in 9\~14,24\~28 and 32\~37 gestational weeks separately. the investigators will also perform oral examination between 24\~28 weeks and sample subgingival plaque for test. overall, all samples will be examined use 16s rrna gene sequencing to analyze microbiome. and part of the samples of gdm patients will be analyzed using metagenomics. combine with the pregnancy outcomes, the differences of gut and oral microbiome between gdm patients and healthy women will be expected, as well as the natural change during pregnancy.

Eligibility criteria:
inclusion criteria: * pregnant women * gestational age: before 13+6 weeks * regular prenatal care in pumch exclusion criteria: * have medical history or current conditions： gastrointestinal disorders, for example: gastritis, gastric ulcer, inflammatory bowel disease; hypertension; diabetes; sle or other severe ctd; * pregnant, combine with malignancy diseases; * pregnant, can't ensure regular prenatal check.

Keywords: gastrointestinal microbiome pregnancy gestational diabetes mellitus
complementary testing to evaluate immunogenicity of human papillomavirus (hpv) vaccine (580299) in healthy female subjects aged >/= 26 years

Conditions: Infections, Papillomavirus

Summary: infection with human papillomavirus (hpv) has been clearly established as the central cause of cervical cancer. indeed, certain oncogenic types of hpv can infect the cervix (part of the uterus or womb). this infection may go away by itself, but if it does not go away (this is called persistent infection), it can lead in women over a long period of time to cancer of the cervix. this study will supplement an ongoing study evaluating the safety, efficacy and immunogenicity of the vaccine in women aged 26 years and above. this study will therefore assess additional immunogenicity parameters of the vaccine in women from selected investigative sites. the protocol posting has been updated in order to comply with the fda amendment act, sep 2007.


Eligibility criteria:
inclusion criteria: * a female enrolled in study 104820 and who received three doses of study vaccine/control. * subjects who the investigator believes that they can and will comply with the requirements of the protocol should be enrolled in the study. * written informed consent obtained from the subject prior to enrolment in this ancillary study. exclusion criteria: * pregnancy. * administration of any hpv vaccine other than that foreseen by the study protocol. * use of any investigational or non-registered product (drug or vaccine) other than the study vaccine since study start. * chronic administration of immunosuppressants or other immune-modifying drugs since study start. * administration of immunoglobulins and/or any blood products within 90 days preceding a blood sampling.

Keywords: human papillomavirus
prevalence of urinary incontinence in different age categories

Conditions: Urinary Incontinence

Summary: introduction: urinary incontinence (ui) is considered erroneously by many as being a phenomenon of the aging process, however there is a growing prevalence of complaints of ui in nulliparous and nulligest young women. objective: to investigate the prevalence of urinary incontinence in women of different age groups. method: 78 nulliparous and nulligest women of different resident age groups in the city of france, being these divided in: g1 (10-18 years); g2 (20-35 years); g3 (45-60 years) and g4 (65-75 years). excluded from this study were women with cancer or surgeries of the inferior urinary treatment, urinary infection, alterations cognitive, pregnant and obesity. all the participants were questioned as a perception of urine loss, to the efforts or effortlessly evident.

all participants were asked about perceived loss of urine, the effort or without apparent effort. the responses of participants from g1 were offered by parents and / or responsible.

Eligibility criteria:
inclusion criteria: * nulliparous and nulligest women exclusion criteria: * women with cancer reported * surgeries of the inferior urinary treatment * urinary infection * cognitive alterations * pregnant * obesity

Keywords: urinary incontinence
evaluation of survival prognostic factors for patients with exocrine pancreatic cancer resectable or potentially resectable

Conditions: Pancreatic Cancer

Summary: this study aims to collect clinical, biological and quality of life data from patients with a borderline or resectable pancreatic cancer. it will collect information from the date of diagnosis along the therapeutic care of the patients, and a 3-years follow-up after the end of the treatment. the database will be updated at each patient's visit. biological samples will include: tumor, and plasma. epidemiological data will also be collected, whereas quality of life will be assessed by the eortc standard. the objectives of this database are to identify new biomarkers (genomic, immunologic, and epidemiologic) and promote high quality standard research protocol.


Eligibility criteria:
inclusion criteria: * patients with exocrine resectable pancreatic adenocarcinoma or potentially resectable (that after neoadjuvant treatment are considered appropriate candidates for resection) * histologically or cytologically documented diagnosis of exocrine pancreatic adenocarcinoma * written informed consent obtained prior enrollment in the study exclusion criteria: * other types of pancreatic cancer, in particular endocrine tumor or acinar cells * ampulloma * metastatic disease * other malignancy within the last 5 years, except for adequately treated carcinoma in situ of the cervix or squamous carcinoma of the skin, or adequately controlled limited basal cell skin cancer * patient with any medical or psychiatric condition or disease which would make the patient inappropriate for entry into this study * patient under guardianship, curator or under the protection of justice.
videomusic and psychic trauma

Conditions: Post Traumatic Stress Disorder

Summary: this project is interested in the flow of consciousness and its modalizations during psychological trauma (post-traumatic stress disorder) and its resolution. it is based on the premise that in ptsd, consciousness becomes more rigid, less fluid, due to the memory always imposing itself on the consciousness. the resolution of the trauma and the subsequent reduction of anxiety might improve the fluidity of consciousness and thus lead to an overall improvement in the psychological state of ptsd patients. in cases of ptsd, music has been shown to reduce anxiety from the very first session and has a very positive effect on all ptsd symptoms. in this project the following elements will be evaluated : on one hand, the changes in consciousness and its fluidity and, on the other hand, the evolution of anxiety following the listening of a new kind of work, videomusic (which associates a video scenario with music) exemplifying (metaphorizing) the trauma and its resolution.


Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age * patients diagnosed with simple post traumatic stress according to dsm 5 criteria * patient able to express consent prior to participation in the study * patient affiliated to or beneficiary of a social security regimen exclusion criteria: * other serious psychiatric pathologies * serious chronic pathologies, especially neurological ones * epilepsy * blindness or deafness * psychiatric decompensation * pregnant women * patient under judicial protection (guardianship, curatorship...) or justice safeguard * any other reason that, in the opinion of the investigator, could interfere with study objective evaluation

Keywords: psychic trauma phenomenology consciousness anxiety music videomusic
duke apol1 research biorepository

Conditions: End Stage Kidney Disease

Summary: the duke apol1 nephropathy biorepository aims to address needs within non-diabetic kidney failure research by utilizing existing and, when necessary, developing new infrastructure to support the consent of patients and the collection of dedicated samples for apol1 nephropathy biorepository. the mutations in apol1 gene that are strongly associated with kidney disease are only present in individuals of recent african ancestry (i.e., black people). caucasians do not have these apol1 mutations nor the associated kidney disease. therefore, majority of subjects recruited for this study will be self-identified african americans, afro-caribbean and other black individual. study subjects will include individuals with end stage kidney disease and those without any clinical evidence of kidney disease. additionally, healthy black adults with no known history of kidney disease will be recruited as controls in this study because they are the only group that can fill this role.

the risk of end stage kidney failure among african americans is 4 times that of caucasian americans. this excess risk of kidney failure is largely attributable to mutations in apolipoprotein l1 gene. while 10-15% of african americans in the united states possess kidney disease-associated apol1 mutations, nearly 40% of african americans on dialysis have these mutations. there are significant gaps in the understanding of the pathophysiology of apol1-nephropathy. only some of the people with apol1 mutations develop kidney failure. the pathways that link apol1 mutations with end stage kidney failure are not understood. because kidney biopsy is generally obtained from patients with evidence of kidney disease-whose kidneys have experienced significant damage and sclerosis-access to the relevant kidney cells is very limited. however, recent advancements in biomedical research have made it possible to develop kidney-like cells from inducible pluripotent stem cells (ipscs) which were derived from blood cells of individuals. this innovative technique will allow us to generate ipsc-derived cells from the blood of individuals who have developed apol1-nephropathy for the purpose studying them in research lab so as to decipher the cellular mechanism of their kidney failure.

Eligibility criteria:
inclusion criteria: * majority of subjects recruited for this study will be self-identified african americans, afro-caribbean and other black individuals. study subjects will include individuals at various stages of kidney disease and those without any clinical evidence of kidney disease. * healthy black adults, age 50 and older with no known history of kidney disease will be recruited as controls exclusion criteria: * black adult cases with diabetic nephropathy * healthy controls with kidney disease

Keywords: eskd apol 1 gene kidney disease
soother trial to treat rectal itch

Conditions: Pruritus Ani

Summary: longitudinal, observational, single-arm trial of a novel, composite lidocaine ointment to treat rectal itch (pruritus ani)


Eligibility criteria:
inclusion criteria: * presence of pruritus ani (anal itch/discomfort) for at least 2 weeks, and a compatible physical exam. exclusion criteria: * inability to understand informed consent, history of inflammatory bowel disease, known venereal disease, or immunodeficiency disease, history of or current anal or perianal abscess, anal or rectal surgery within the past 12 weeks, pregnancy or breastfeeding female, or signs of other rectal diseases such as anorectal fistula, infection, perianal eczema or tumors.

Keywords: pruritus ani rectal itch anal itch