Kornimate/medical-research-clean huggingface dataset:
application of augmented reality (ar) in hiv self-test in men who have sex with men community

Conditions: Hiv

Summary: objective: to apply augmented reality (ar) technology in hiv self-test and to assess its impacts in enhancing testing performance among men who have sex with men (msm). design: parallel randomised controlled, open label, trial. block randomisation with a block size of 4 would be used to allocate the study arms. participants: men who have sex with men in hong kong intervention: self-test assisted by ar vs self-test with instruction sheets main outcome measures: effectiveness, usability, learnability, efficiency and satisfaction scores; rate of completion and result upload; acceptability of ar approach in assisting self-test anticipated results: 200 msm would be recruited with 50 and 150 in control and intervention group, respectively. the scores in the intervention group are 10% higher than the control group. proportion of satisfied participants in the intervention group is 10% more than the control group. ar approach is feasible and acceptable to msm for assisting in hiv self-test.

about 200 msm would be recruited through community-based organisations and internet channels where msm socialise and seek partners. fifty and 150 participants would be randomly assigned into the control and intervention group by block randomisation with a block size of 4, respectively. after giving informed consent, subjects would be invited to complete an online questionnaire and request for an hiv self-test kit in the online portal before randomisation. participants in the control group would be given a standard commercially available self-test kit which included bilingual instruction sheets. subjects in the intervention arm would be asked to use the ar element to assist the same standard commercially available self-test kit. all participants would be asked to upload the test result and complete a post-test questionnaire on the usability of the test and the ar approach. the result would be validated by an experienced research staff. subjects with a positive result would be contacted for follow up. main outcome measures in this study would include the confidence in performing the self-test and the usability of hiv self-testing between the two arms.

Eligibility criteria:
inclusion criteria: * adult men who have sex with men * has access to a smartphone with internet access exclusion criteria: * unable to communicate in written chinese or english * unable to give informed consent
double trigger in patients with low number of oocytes retrieved per number of preovulatory follicles

Conditions: Infertility, Female

Summary: the aim of this randomized controlled trial is to determine whether co-administration of gnrh agonist and hcg for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to coh, due to low (\ 14 mm in diameter on day of hcg administration


Eligibility criteria:
inclusion criteria: * patients with history of poor oocytes yield in previous ivf attempt, despite normal response to coh, due to low (\ 14 mm in diameter on day of hcg administration * patients with 6 to 15 mature follicles on the day oocyte trigger in the current ivf-et attempt exclusion criteria: * endometriosis * pcos

Keywords: ivf hcg gnrh agonist trigger
change in inflammatory state in patients undergoing transcatheter ablation of atrial fibrillation

Conditions: Atrial Fibrillation; Marker of Inflammation; Inflammation; Arrhythmia

Summary: it is a non-pharmacological (biological), spontaneous observational study. the main objective is to evaluate the correlation between inflammation markers and local adiposity, clinical risk factors and their possible variation following an af ablation procedure

the study includes the execution of a sample for each time point for the evaluation of inflammation and fibrosis markers identified so far in the literature, such as interleukin 6, n-terminal propeptide of procollagen type 1 (p1np), chitinase-3-like protein 1 (ykl-40), tumor necrosis factor (tnf-alpha), glyca, proprotein convertase subtilisin/kexin type 9 and omega-3 fatty acids.

Eligibility criteria:
inclusion criteria: * paroxysmal or persistent af; * patients undergoing esc/erah(european society of cardiology/european heart rhythm association) approved catheter ablation procedures; * aged between 18 and 85 years; * ability to provide informed consent for study participation. exclusion criteria: * age \> 85 years or \< 18 years; * presence of left auricular thrombosis on pre-procedural transesophageal echocardiogram; * nyha functional class iv; * left ventricular ejection fraction \<30%; * myocardial infarction or unstable angina or recent coronary artery bypass graft (\<6 months); * significant co-morbidity, such as cancer, severe renal failure requiring dialysis, severe obstructive pulmonary disease, cirrhosis, with a life expectancy of less than 12 months; * presence of contraindications to the procedure; * inability to provide informed consent for study participation.
internet self-management for people with intermittent urinary catheters

Conditions: Spinal Cord Injury

Summary: 1. design and develop web-based self-management intervention to improve catheter-related outcomes and quality of life in people with spinal cord injury (sci). 2. conduct a pilot study to assess the feasibility (i.e., acceptability and usability of the website application) and preliminary effectiveness of this new self-management intervention. 3. develop and test the reliability of new/modified measures (intermittent catheter self-efficacy and self-management).

stages involve: (1) develop an internet-based intervention to improve self-management and outcomes related to clean intermittent catheterization (cic) among people with sci (2) pretest the internet application with five persons with sci using cic; and (3) conduct a web-based six-month intervention pilot study in a group of 30 with sci using cic. outcomes are: catheter-related adverse health outcomes (e.g., uti, urine leakage), cic self- management, cic self-efficacy, health related expenditures and quality of life. information from this study will be used to modify the internet application for a future phase 2 trial in a larger study.

Eligibility criteria:
inclusion criteria:individuals will be included if they are english speaking adults over 18 years with an sci and are interested in participating. inclusion criteria are: 1. use of cic for regular bladder drainage, 2. expect to use cic indefinitely or for at least nine months, and 3. access to and ability to use a computer and telephone. computer and telephone use may be voice activated for those with little hand use. study participants do not need to perform cic entirely themselves, as people with limited hand dexterity may have caregivers who do the procedure. they do need to be able to use the computer and telephone however. additional inclusion criteria for the five persons in the "intervention and pretesting group" (described below in iii, 1) include: 1. having used cic for regular bladder drainage for at least one year and 2. expect to use cic indefinitely or for at least one more year. people will need to have used cic for at least a year so that they are well experienced in cic because the two peer leaders will be selected from this group. exclusion criteria: * people will be excluded if they cannot communicate in english, * are terminally ill, or are expected to discontinue cic within the next nine months. - non-english speaking people will not be included because translated instruments (e.g., spanish) are not available for all measures and doing this as a part of this small study might compromise the integrity of this first test of preliminary effectiveness.

Keywords: self-efficacy self-management web-based intervention research
swallowing difficult sensation after cervical spine surgery

Conditions: Swallowing Disorder

Summary: in many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. in addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow transmission was still not evaluated, which still depended on the videofluoscopic swallowing studies. high resolution impedance manometry could help us to measure the bolus flow according to the impedance changes. however, the comparison between two approach methods of postoperative recovery of swallowing function is still inconclusive. the investigator aimed to examine the correlation between high-resolution manometric and videofluoroscopic measurements of the swallowing function.

background: in many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. in addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow transmission was still not evaluated, which still depended on the videofluoscopic swallowing studies. high resolution impedance manometry could help us to measure the bolus flow according to the impedance changes. however, the comparison between two approach methods of postoperative recovery of swallowing function is still inconclusive. objectives: the objective of the current study was to examine the correlation between high-resolution manometric and videofluoroscopic measurements of the swallowing function. patients and methods: consecutive patients who will fulfill the criteria of postoperative cervical spine surgery patients aged \>= 20 will be enrolled and the dysphagia questionnaire score (eat-10) was higher than 3, including 3. after got the inform consent, these patients receive the swallowing function by videofluroscopy and hrim. expected result: the investigator will evaluate the swallowing changes of these postoperative cervical spine patients with suspected dysphagia. the investigator expected that the highly correlation between the hrim and vfss.

Eligibility criteria:
inclusion criteria: * \> 20 years old * postoperative cervical spine surgery * eat-10 questionnaire exclusion criteria: * pregnancy * bleeding tendency * heart or lung failure
electromyographic biofeedback and physical therapy in upper limb hemiparesis

Conditions: Electromyography

Summary: the aim of this study was to assess the effect of a specific protocol of semg-bfb in upper limb hemiparesis added to conventional physical therapy on changes in upper extremity functionality, motor recruitment pattern and range of motion (rom) compared to the single application of conventional physical therapy. it aims to find a 22.22% difference between both interventions.

upper limb hemiparesis is a common consequence after brain damage. objective: to evaluate the effect of a specific protocol of surface electromyographic biofeedback (semg-bfb) and conventional physical therapy in upper limb functionality, muscle recruitment changes, and glenohumeral range of motion compared to the single application of conventional physical therapy. design: randomized controlled clinical trial. sample: 40 participants from state center of attention to brain injury were recruited. interventions: patients were randomly assigned to 2 groups where the experimental group received semg-bfb for the upper trapezius and middle deltoid muscles of the upper limb with hemiparesis and the control group received a placebo of the same technique. both treatments were applied for 6 weeks. the score of the fugl-meyer assessment-upper extremity" for functionality and shoulder range of motion were objectified. root mean square (rms) value was assessed as a secondary measure data were collected before and after intervention. a protocol of semg-bfb in upper limb may have an important role in the recovery of subjects with upper limb hemiparesis.

Eligibility criteria:
inclusion criteria: * acquired brain injury after two months of medical evolution at least; * suffer paretic upper limb; * spasticity no greater than 3 in the modified ashworth scale; * minimum active rom of 20º of glenohumeral abduction. exclusion criteria: * peripheral nerve injury, fractures of upper limb, cervical radiculopathy, complete luxation of the shoulder and severe cognitive impairment.

Keywords: brain injuries upper extremity biofeedback electromyography recovery of function
changes in velocimetric indices of uterine and umbilical arteries before and after combined spinal-epidural analgesia in laboring women

Conditions: Labor Pain

Summary: combined spinal-epidural (cse) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief. cse is not only beneficial for its faster onset of analgesia, but also it is favorable in relation to the need for rescue analgesia, urinary retention, and rate of instrumental delivery compared to the traditional epidural. despite its beneficial effects, there is a risk of about 15-30% of developing abnormal fetal heart rate following cse. this is self-resolving with minimal or no intervention. although the cause of fetal bradycardia is not fully elucidated, variations in uterine artery blood flow after epidural analgesia are thought to be due to the interaction of numerous events related to blockade of sympathetic innervations, fluid administration, maternal hypotension, uterine vascular effects of sympathetic block, fluctuations in circulating catecholamines, and possibly the effect of opioids. similar mechanism is thought to be a cause of fetal bradycardia after the cse with its faster onset and superior block. maternal or fetal circulation during labor can be assessed using continuous-wave doppler ultrasound to monitor maternal uterine artery (uta) and fetal umbilical artery (uma) velocity waveforms to detect changes in blood flow. the velocimetry indices mentioned above have been often used to assess the changes in the blood flow before and after the induction of epidural analgesia during labor in several studies. although there are some studies regarding the effect of labor epidural analgesia using velocimetry indices, but there is currently no published study evaluating velocimetry indices of uterine and umbilical arteries before and after the induction of cse. thus, the aim of this study is to investigate the impact of cse to maternal and fetal blood flow to evaluate the relationships. the investigators hypothesize that both uterine artery and umbilical artery blood flow are reduced after the induction of cse, which may be responsible for the occurrence of fetal bradycardia.


Eligibility criteria:
inclusion criteria: * written informed consent * term pregnant patients requesting labor analgesia * singleton pregnancy * term pregnant patients in active labor * asa\<4 * no evidence of fetal congenital anomalies, fetal compromise or fetal decelerations prior to cse exclusion criteria: * refusal to consent for the study * known spinal deformities * previous back instrumentation * patients with bmi\>50 kg/㎡ due to anticipated technical challenges in doppler studies

Keywords: combined spinal epidural (cse) fetal bradycardia ultrasound velocimetric index
attention training and its effects on body image disturbance

Conditions: Body Dissatisfaction; Eating Disorder Symptoms

Summary: research has consistently found attentional biases towards negative weight-related stimuli in individuals with eating disorders. it has been suggested that these biases may act as a vulnerability factor for the development and maintenance of body dissatisfaction and may therefore be an important target for intervention. previous studies have demonstrated the capacity to modify the patterns of attention allocation to threatening stimuli in a variety of anxiety disorders, with a subsequent and sustained reduction in anxiety symptoms. thus, the present study aimed at testing the efficacy of attention training in reducing attentional biases and eating disorder symptoms in individuals with elevated levels of body image disturbance and eating disorder symptomatology of clinical severity. thirty-two participants were randomly allocated to receive eight sessions of a 10-minute computer task aimed at training their attention away from weight-related stimuli or a control placebo training condition. results showed that participants in the attention training group had a significantly greater reduction in their attentional bias and body dissatisfaction from pre- to post-training relative to the placebo condition. at follow-up, both groups showed a significant decrease in body dissatisfaction from their pre-training levels. the only significant difference between groups in eating disorder symptoms at follow-up was in terms of the attention training group experiencing a greater reduction in weight and shape concerns.


Eligibility criteria:
inclusion criteria: * if they have a score on the body shape questionnaire of 113 or more and a score in the ede-q of 4 or more in any subscale. exclusion criteria: * attention bias score of \<-10
effects of action observation therapy with otago exercises on balance and quality of life in older adults

Conditions: Balance; Distorted

Summary: this study is to determine to see the effect of action observation therapy with otago exercise on balance and quality of life.

this study is designed to reduce the fall and balance problems and increase the quality of life in older adults. balance, which declines with aging, is a complex sensory-motor process in which the visual, vestibular, and musculoskeletal systems work cooperatively to produce postural stability and loss of balance control causes falls, resulting in severe injuries, such as fractures, causing longstanding pain, lower quality of life, disability, and even death. interventions include balance and postural control that can help older people to avoid falling, through tai chi methods, gait training, strengthening exercises, and balance training programs. the otago exercise program comprises muscle strength exercises, balance training, and walking. the otago workout program is based on individual tolerance, consisting of strengthening, balance, walking, and aerobic activities, and can be done at home environment action observation is a cognitive intervention training strategy that involves observing other people's performance in order to promote motor learning. participants were instructed to watch a video on a screen while comfortably seated in a chair with armrests. they were not allowed to follow along or engage in any movement while watching the video. after the watching video of each component of otago exercises the exercises performed by participant based on the content of the video.

Eligibility criteria:
inclusion criteria: * both genders * participant experience fall \> one time in last 6 months. * participants having berg balance score between 20 to 40 exclusion criteria: * ●abnormalities in visual, auditory, or vestibular system * limb defects * history of recent fractures * participants with cardiovascular, cerebrovascular disease or traumatic brain injury and epilepsy
phase ii study of teriflunomide as adjunctive therapy to glatiramer acetate in subjects with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the primary objective was to estimate the tolerability and safety of 2 doses of teriflunomide administered once daily for 24 weeks, compared to placebo, in patients with multiple sclerosis \[ms\] with relapses who were on a stable dose of glatiramer acetate \[ga\]. the secondary objectives were: * to estimate the effect of the 2 doses of teriflunomide, compared to placebo, in combination with a stable dose of ga on magnetic resonance imaging \[mri\] parameters, relapse rate and patient-reported fatigue; * to perform pharmacokinetic analyses of the 2 doses of teriflunomide in combination with a stable dose of ga.

the duration of the study period for a participant was approximatively 44 weeks broken down as follows: * screening period up to 4 weeks, * 24-week double-blind treatment period\*, * 16-week post-treatment elimination follow-up period. '\*' participants successfully completing the week 24 visit were offered the opportunity to enter the optional long-term extension study lts6047 - nct00811395.

Eligibility criteria:
inclusion criteria: * definite ms diagnosis according to mcdonald's criteria; * relapsing clinical course, with or without progression; * expanded disability status scale \[edss\] less or equal to 5.5 (ambulatory); * stable dose of glatiramer acetate \[ga\] for at least 26 weeks prior to the screening visit; * no onset of ms relapse in the preceding 60 days prior to randomization; * clinically stable for 4 weeks prior to randomization. exclusion criteria: * other chronic disease of the immune system, liver function impairment or chronic pancreatic disease; * pregnant or nursing woman; * alcohol or drug abuse; * use of cladribine, mitoxantrone, or other immunosuppressant agents such as azathioprine, cyclophosphamide, cyclosporin, methotrexate or mycophenolate before enrollment; * human immunodeficiency virus \[hiv\] positive status; * any known condition or circumstance that would prevent in the investigator's opinion compliance or completion of the study. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: ms glatiramer acetate adjunctive therapy relapses
treatment with aspirin after preeclampsia: tap trial

Conditions: Hypertensive Disorder of Pregnancy; Pre-Eclampsia; Hypertension; Eclampsia; Gestational Hypertension; Cardiovascular Diseases; Toxemia; Pregnancy Complications; Vascular Diseases; Hypertension, Pregnancy Induced; Hypertension;Pre-Eclamptic

Summary: the objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower bp at 6 months postpartum. subjects will undergo 3 study visits involving bp measurements, blood draws, questionnaires, and/or microiontophoresis. up to 60 adult subjects will be enrolled at magee-women's hospital.

this is a pilot randomized, single-center, double-blind placebo-control study of low dose aspirin in postpartum individuals with preeclampsia. individuals will be randomized at the time of delivery 1:1 to 81mg of low-dose aspirin or identical appearing placebo daily for six months postpartum. treatment and control groups will monitor home blood pressure throughout the study period and undergo two study visits. at each study visit, participants will undergo a blood draw, blood pressure measurement and assessment of endothelial function with microiontophoresis. participant adherence will be monitored through pill counts, text message check-ins, patient diary and biochemical monitoring.

Eligibility criteria:
inclusion criteria: * postpartum individuals ≥18 years old * preeclampsia diagnosis exclusion criteria: * fetal anomaly * multiple gestation * pre-pregnancy hypertension * allergy or contraindication to low-dose aspirin * pre-pregnancy diabetes

Keywords: hypertension