Kornimate/medical-research-clean huggingface dataset:
avecure flexible microwave ablation probe for lung nodules

Conditions: Stage I - II Primary Lung Cancer; Stage I Lung Cancer; Stage II Lung Cancer; Lung Cancer Stage I; Lung Cancer Stage II; Lung Cancer

Summary: this research study to determine the effectiveness of the avecure flexible microwave ablation probe to destroy cancerous lung nodules up to 3 c m in size. this research study involves microwave ablation (mwa)

this will be a single arm, prospective cohort study. the names of the study intervention involved in this study is: * cone beam computed tomography (cbct)-guided electromagnetic navigational bronchoscopy (enb) microwave ablation (mwa) * a rapid on-site evaluation (rose) will be performed before the mwa to confirm that the lesion is malignant, this can lead to longer procedure time and time under anesthesia. the research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. * participants will receive the study intervention and will be followed for 30 days. * it is expected that about 10 people will take part in this research study. this research study is a pilot study, which is the first-time investigators are examining this intervention using a bronchoscopic approach for microwave ablation of solitary pulmonary nodules. the u.s. food and drug administration (fda) has approved this intervention as a treatment option for this disease.

Eligibility criteria:
inclusion criteria: * subject with stage i - ii primary lung cancer (solitary nodules up to 3 cm) as defined by previous pathology or rose. * pathological proof of target nodule/tumor type and malignancy with specimen considered adequate per institutional laboratory standards * target nodule/tumor which can be accessed via navigational bronchoscopy and confirmed location with cone beam ct scan intra-operatively * resection/surgical candidate (lobectomy or greater) * participants must be at least 22 years old and able to provide consent exclusion criteria: * subjects in whom flexible bronchoscopy is contraindicated * target nodule \< 1.0 cm * prior radiation or neo adjuvant chemotherapy of the target nodule/tumor * any comorbidity that the investigator feels would interfere with the safety of the subject or the evaluation of study objectives * pacemaker, implantable cardioverter, or another electronic implantable device * patient cannot tolerate bronchoscopy * patients with coagulopathy * patients in other therapeutic lung cancer studies * subject is pregnant or breastfeeding * covid-19 positive patient at the time of procedure.

Keywords: stage i - ii primary lung cancer stage i lung cancer stage ii lung cancer lung cancer stage i lung cancer stage ii lung cancer
changes in blood flow in mca of fetuses to mothers having clinical chorioamnionitis

Conditions: Chorioamnionitis

Summary: this study will try to determine whether fetuses to mothers having clinical chorioamnionitis have changes in blood flow in middle cerebral artery.

this study will try to determine whether fetuses to mothers having clinical chorioamnionitis have changes in blood flow in middle cerebral artery. mca flow parameters will be evaluated during labor of women with and wthout chorioamnionitis

Eligibility criteria:
inclusion criteria: * women giving birth week 37-42 * healthy * one fetus exclusion criteria: * more than one fetus * iugr * illness or damage to fetus
evaluation between zirconia and stainless steel crowns

Conditions: Tooth Diseases

Summary: introduction and research problem: the aim of this project is to evaluate and compare two full coronal restorations on primary posterior molars over a period of 3, 6 and 12 months in terms of restoration failure, marginal integrity, proximal contact, secondary caries, occlusion and gingival response. the restorations types are stainless steel crowns (ssc) and nusmile zirconia crowns (nu/zr). materials and methods: children attending the king abdulaziz university, faculty of dentistry (kaufd) clinics who need restorations will be screened for inclusion criteria till 120 teeth are recruited (60 teeth for ssc restorations and 60 for nu/zr restorations). split mouth technique will be used to ensure equalizing variables for both groups, each patient will have side restored with ssc and the opposite side will be restored with nu/zr crowns. randomization will be done using statistical package for the social sciences (spss) software version 20.0 (armonk, new york; international business machines corporation (ibm corp) for each age group separately with a uniform random variable generation. a simple descriptive statistics will be used for analysis and a t-tests with wilcoxon signed-rank will be used. level of significance will be set at (α = 0.05) and level of confidence at (95%).


Eligibility criteria:
inclusion criteria: * age group of 4-8 years * free of any systemic disease * cooperative patient * at least two matched bilateral carious primary molars * minimal of two surfaces of caries in the targeted tooth * written consent obtained from the parent/guardian exclusion criteria: * any subject that does not fall under the inclusion criteria were excluded.

Keywords: stainless steel crowns zirconia crowns aesthetic restorations
the effects of chiropractic in adults with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the purpose of this study is to assess the feasibility of our study procedures/protocols and to look at the potential effects of chiropractic care on people with metabolic syndrome.

after providing informed consent, individuals will undergo 6 weeks of chiropractic care. throughout these 6 weeks there will be three assessments (day 0, week 2, and week 6) that each include the following: 1. seated resting recording 2. auditory oddball task 3. isometric hand grip 4. postural challenge 5. treadmill walking 6. patient-reported outcome surveys each assessment will consist of the following recordings: 1. electroencephalography \[eeg\] 2. electrodermal activity \[eda\] 3. impedance cardiography \[icg\] 4. electrocardiogram \[ecg\]

Eligibility criteria:
inclusion criteria: * individuals over the age of 18 * individuals who can wear an eeg net for 30 minutes * individuals who can sit quietly for at least 15 minutes * individuals who can walk unassisted for up to 10 minutes * individuals who can provide informed consent * individuals who meet 3 of the 5 following criteria: * elevated waist circumference (\>40 in/102 cm if male and \>35 in/88cm if female) * elevated triglycerides (\>150 mg/dl) or drug treatment for elevated triglycerides * reduced hdl-cholesterol (\<40mg/dl if male and \<50 mg/dl if female) or drug treatment to increase hdl-c * elevated blood pressure (\>130 mm hg systolic bp or \>85 mm hg diastolic bp) or drug treatment to reduce blood pressure * elevated fasting glucose (\>100 mg/dl) or drug treatment to reduce blood glucose exclusion criteria: * individuals with a known disorder resulting in syncope/fainting during postural changes (e.g., pots, orthostatic hypotension) * individuals with impaired function of the dominant hand * individuals with malignant hypertension * individuals with a known heart condition such as arrhythmia that results in an aberrant ecg recording * individuals with any implanted devices (i.e., pacemakers) * individuals with brain aneurysms * individuals with a history of epilepsy or stroke that would influence eeg readings * individuals with a diagnosed externalizing or thought disorder (i.e., anti-social disorder, any major personality disorder such as borderline personality disorder, or schizophrenia) * individuals who are on short-acting benzodiazepines which include midazolam \& triazolam * individuals with any serious injury or surgery to the head or torso, or lower body in the last 6 months * individuals with a hearing impairment or hearing aids (due to the auditory stimulus recording being performed) * individuals who are currently pregnant * individuals with current litigation related to a physical, health-related injury * individuals who have been diagnosed with rheumatoid arthritis, osteoporosis or instability of the neck. * individuals with moderate to severe pain on a daily basis * pain on the day of testing rated greater than 3/10 on a visual analog scale (vas)

Keywords: chiropractic metabolic syndrome spinal manipulation autonomic nervous system eeg patient reported outcomes
bevacizumab (avastin) into the tumor resection cavity in subjects with glioblastoma multiforme at first recurrence

Conditions: Glioblastoma Multiforme

Summary: this is a phase 1b study for safety and tolerability of bevacizumab(avastin)administered into the tumor resection cavity in subjects with glioblastoma multiforme (gbm) at first recurrence.


Eligibility criteria:
inclusion criteria: 1. recurrent glioblastoma 2. at least 12 weeks expected survival (kps \>60) 3. 18 years of age or older 4. able and willing to participate exclusion criteria: 1. any prior diagnosis of any other cancer or other concurrent malignancy. 2. planned use or current use of other investigation therapy. 3. systemic autoimmune disease 4. hiv positive 5. concurrent life threatening disease 6. impaired organ function 7. active infection 8. inadequately controlled hypertension 9. congestive heart failure 10. myocardial infection/unstable angina within 6 months 11. stroke within 6 months 12. pheripheral vascular disease 13. history of abdominal fistula/gastrointestinal performation 14. non-healing wound 15. coagulation disease 16. known allergy to study treatments 17. pregnant or lactating

Keywords: brain tumor gbm brain cancer
evaluating vitamin d content in mushrooms

Conditions: Vitamin D Deficiency

Summary: this study will evaluate how much vitamin d is present in a mushroom supplement. this supplement contains an extract from mushrooms that have been exposed to sunlight. the mushroom supplement will be compared to non-commercially available vitamin d supplements produced in a goo manufacturing practices (gmp)-licensed facility.

mushrooms have the capability to produce vitamin d in a similar way to human skin. when exposed to ultraviolet light, mushrooms will convert a precursor to vitamin d. this reaction produces large amounts of vitamin d. this study is comparing a natural source of vitamin d to a synthetic source of vitamin d and will help determine if mushrooms are a novel source for this essential nutrient.

Eligibility criteria:
inclusion criteria: * all healthy adults, male and female, age 18-64 years exclusion criteria: * currently taking, or having taken less than one month prior to start of study, a prescription of 50,000 iu of vitamin d2 or 2000 iu vitamin d2 or vitamin d3 * allergy to mushrooms * history of elevated calcium (\>10.4 mg%) * patients with a current or recent history of severe, progressive, and/or uncontrolled renal, hepatic, hematological, endocrine, pulmonary, cardiac, neurological, or cerebral disease. * supplementation with over the counter formulations of vitamin d2 or vitamin d3 * subjects with a history of an adverse reaction to orally administered vitamin d. * subjects who are taking oral dilantin or glucocorticoids. * exposure to a tanning bed or tanning on a beach for more than eight hours with no sunscreen within 2 weeks prior to start of study. * history of intestinal malabsorption (i.e. cystic fibrosis, fat malabsorption syndrome, crohn's disease, gastric bypass surgery). * subjects with any other condition which in the investigator's judgment would make the patient unsuitable for inclusion in the study.
racial and economic disparities and unmet needs in patients with severe aortic valvular disease

Conditions: Disparities in Treatment of Aortic Valve Stenosis; Aortic Valve Stenosis

Summary: common barriers to receiving appropriate guideline-driven care for patients with severe aortic stenosis include referral biases by primary care providers (lack of provider education), patient comorbidities (degree of fragility), as well as psychosocial issues and cultural barriers. additionally, race, ethnicity, socioeconomic status (ses) and education level are shown to be persistent barriers to accessing healthcare services and healthcare systems, creating a significant practice gap between various patient populations. the most recent transcatheter valve therapies (tvt) registry data show that \>94% of tavr recipients are caucasian, followed by less than 4% of african-americans and hispanics, respectively. there is a critical need to understand the barriers to treatment and care among severe aortic valve disease patients of disparate groups. this study is a multi-center, retrospective and prospective cohort study of patients diagnosed with severe aortic stenosis. additionally, we will be surveying referring primary care providers, cardiologists and cardiovascular surgeons to assess their current referral practices for patients with severe aortic stenosis.


Eligibility criteria:
inclusion criteria: * disparity/diversity background (either race/ethnicity, low ses (adults with incomes at or below the federal poverty level (family income to poverty ratio, ≤1), language (non-english speaker) or education (≤9 years of education)) * patient scheduled for transcatheter aortic valve replacement using the edwards sapien valve, or recently implanted with edwards sapien valve (up to 1 year post-tavr) * echocardiographic diagnosis of severe, symptomatic as and intermediate to high surgical risk per society of thoracic surgeons (sts) mortality risk-score exclusion criteria: * age \< 18 * patients who do not allow their records to be used for research

Keywords: aortic valve stenosis disparities
effects of tamsulosin 0.4mg on clinical outcomes in korean men with severe symptomatic benign prostatic hyperplasia (bph)

Conditions: Benign Prostatic Hyperplasia

Summary: the purpose of this study is to compare the efficacy and safety of tamsulosin 0.4mg (harnal® d. 0.2mg, 2t) with tamsulosin 0.2mg (harnal® d 0.2mg, 1t) in patients with severe symptomatic benign prostatic hyperplasia as a first line therapy.


Eligibility criteria:
inclusion criteria: * severe luts : ipss ≥ 20 exclusion criteria: * post voided residual urine ≥ 150ml * patients performing catheterization * urinary tract infection patients * patients taking 5 alpha reductase inhibitor * known hypersensitivity to tamsulosin * history of postural hypotension or syncope * hypertension patients treated with other alpha1-blockers * patients newly taking anticholinergic medication within 1 month * hepatic insufficiency (ast/alt ≥ 2 times of normal range) * renal insufficiency (s-cr ≥ 2mg/dl)
high powered stone dusting vs. fragmentation and basketing at time of ureteroscopy

Conditions: Kidney Stone; Ureteral Stone

Summary: the purpose of this study is to determine the differences in stone free results, patient side effects, and patient satisfaction between dusting vs. basket extraction for kidney and ureteral stones (a kidney stone located in the tube between the kidney and bladder) 6 mm and greater in size undergoing ureteroscopic treatment. dusting is when a laser is used to break a stone down into tiny fragments that are able to pass through the urine. basket extraction is when a small wire basket is used to remove stone fragments.

on the day of surgery, the treatment assigned to the patient will be determined by chance, like flipping a coin. neither the patient nor the study doctor will choose the treatment type. each patient will have an equal chance of being given either surgical treatment. one group will have stones treated with high-powered laser dusting and the dust produced will pass spontaneously through the urine. the other group will have stones treated with low power laser fragmentation and stones will be removed using a basket. the surgical procedure will not differ from the treatment a patient would receive if he/she were not in this study. after surgery, participants will complete a pain assessment questionnaire in the outpatient recovery area before being discharged to go home. participants will also receive a daily email or text message to assess pain and daily activities. participants will answer these questions daily until pain has resolved and daily activities have returned to baseline levels. six weeks after surgery, participants will undergo an ultrasound to assess for swelling of a kidney due to a build-up of urine (called hydronephrosis), which is standard of practice after ureteroscopy. participants will also return to the urology clinic 12 weeks after surgery for a standard of care follow up visit. at this visit, participants will undergo standard of care procedures known as renal bladder ultrasound and kidney ureter bladder abdominal x-ray to evaluate for stones. participants will also complete another pain assessment questionnaire at this appointment. researchers will review the medical record to evaluate the effectiveness of the surgery at removing kidney stones and preventing kidney stone recurrence as well as to track quality of life outcomes.

Eligibility criteria:
inclusion criteria: * \>18 years of age * undergoing ureteroscopic stone extraction * stone size 6mm stones or greater and the location to mid ureter or higher * willing to sign informed consent form * able to read, understand, and complete patient questionnaires, and pain questionnaires exclusion criteria: * \< 18 years of age * inability to provide informed consent * concomitant surgery (i.e. percutaneous nephrolithotomy, holmium laser enucleation of the prostate * solitary kidney * nephrocalcinosis * members of vulnerable patient populations * patients without access to a phone that can receive txt messages
quality assessment in endoscopic retrograde cholangiopancreatography(ercp)

Conditions: Cholangiopancreatography, Endoscopic Retrograde; Common Bile Duct Lithiasis; Biliary Strictures; Bile Duct and Pancreatic Tumors

Summary: the investigators will prospectively collect patient and procedure-related data in an observational study in order to detect patient and procedure-related risk factors for poor outcome (i.e. technical failure of the procedure; procedure-related complications). data will be prospectively reported using standard report forms and patients will be followed up to 30 days to detect late-onset complications.

this is an investigator-driven, prospective multicenter trial which analyzes the impact of trainee participation on procedure-related outcome (technical success and procedure-related complications). all ercps in the participating centers will be documented using a standard report form which will require the attending endoscopist to provide data relating to the patient (age, gender, diagnosis, bilirubin levels) and the procedure (including but not limited to the indication, technical aspects including cannulation technique, time to cannulation, degree of trainee involvement - where appropriate, procedure-related adverse events and their outcome). because teaching ercp is not yet a standardized procedure, we aim to assemble a large database, stemming from the experience of several teaching centers in order to identify the main patient and operator-related factors which might influence the outcome of the procedure.

Eligibility criteria:
inclusion criteria: * all patients undergoing ercp with attempted cannulation of either the major or minor papilla exclusion criteria: * refusal to sign the informed consent
brief interventions in chronic migraine

Conditions: Chronic Migraine

Summary: people with chronic migraine headaches face many challenges, including high levels of daily pain, disturbances to everyday activities and sleep, and problems with mood such as depression or anxiety. this trial is being completed to study whether changing an individual's behaviors may have an impact as a treatment for migraine headaches. eligible participants will be randomized to one of the four arms. this study will be conducted remotely without in-person contact. study hypothesis: * there is a main effect of attending either the empowered relief and health education intervention on reductions in migraine-related disability 1 month after completing either intervention * there is a main effect of empowered relief and health education interventions on reducing pain-related catastrophizing and migraine symptom severity 1 month after completing either intervention (secondary hypothesis) * the expected reductions in migraine-related disability, pain catastrophizing, and migraine symptom severity will be maintained at secondary time points (2 months, 3 months, and 6 months after completing either intervention) (secondary hypothesis)


Eligibility criteria:
inclusion criteria: * self-reported neurologist diagnosis of chronic migraine * meets diagnostic criteria for chronic migraine according to the identify chronic migraine (idcm) self-reported instrument * english-speaking * internet access and audio-visual conferencing capability (e.g., zoom meetings by phone or computer) in the home * age 18 years or older exclusion criteria: * currently receiving cognitive-behavioral therapy for pain or migraine * open litigation regarding a medical condition, as assessed in preliminary study screening * inability to provide informed consent and complete study procedures (e.g., indications of suspected major cognitive impairment via observations of study staff during consenting) that would preclude comprehension or participation in study protocols * failure to complete at least 7 out of 14 pre-intervention daily diaries

Keywords: health education migraine-related disability empowered relief
targeted t-cell therapy in solid tumors

Conditions: Malignant Solid Tumor

Summary: this is a single-center, open, single-arm controlled prospective clinical trial of patients with solid tumors treated with targeted activation of t cells through intravenous infusion.the purpose of this study was to evaluate the clinical efficacy and safety of targeted activated t cells in the treatment of solid tumors.

in china, malignant tumors have become the leading cause of death for urban and rural residents, with solid tumors accounting for 77 percent.immunotherapy is considered one of the most promising ways to fight cancer.this study is a single-center, open, single-arm controlled clinical trial (after intravenous infusion of targeted t cells, compare the changes of self-lesion). the essence of this study is to collect immune cells to the surrounding of tumor cells, so that immune cells can kill tumor cells at close range.the researchers plan to enroll 10 patients with solid tumors and follow them up to the end of the study after completing 9 courses of treatment.the results of this study were statistically analyzed using recist1.1 records.

Eligibility criteria:
inclusion criteria:1. age: 18\~75 years old; 2. patients with solid tumors still show progress after radiotherapy, chemotherapy and targeted therapy, with at least one measurable lesion; 3. no congenital autoimmune diseases or immunodeficiency diseases;' 4. at least one or more solid tumor targets of her2, muc1, cea, egfr and gpc3 were positive by immunohistochemical examination of tumor tissues; 5. no serious infectious diseases (hepatitis b, c, syphilis, aids); 6. sign informed consent voluntarily. - exclusion criteria:1. the researchers determined that the patient could not complete 6 courses of treatment. 2. patients with t-cell lymphoma. 3. pregnant or lactating female patients, or those who do not want to use contraception during the trial. 4. allergic to both ct and mri contrast agents and unable to conduct imaging evaluation. 5. other patients in the treated group who were considered as unfit for cell therapy. -

Keywords: targeted t-cell her2 muc1 cea egfr gpc3