Kornimate/medical-research-clean huggingface dataset:
in vitro model of the cystic fibrosis bronchial epithelium via ips technology

Conditions: Cystic Fibrosis

Summary: in order to further enable physiopathology studies, the aim of this project is to validate an in vitro model of cystic fibrosis created using induced pluripotent stemcell (ips) differentiated bronchial epithelium from cystic fibrosis (cf) patients homozygous for the p.phe508del mutation of the cystic fibrosis transmembrane conductance regulator (cftr) gene.

the investigator's primary objective is to generate ips lines from 3 cf patients and from 3 healthy subjects. secondary objectives include verification that cell lines express the cftr gene according to their genotype, verification or relative production of the cftr protein for each ips line, and amplification of obtain ips lines for aliquot creation to facilitate sharing.

Eligibility criteria:
inclusion criteria for subjects with cystic fibrosis: * homozygote for the p.phe508del mutation * signed informed consent given by the subject inclusion criteria for subjects without cystic fibrosis: * signed informed consent given by the subject exclusion criteria: * pregnancy, breastfeeding * participant in an exclusion period determined by a previous study * participant under any kind of guardianship * unaffiliated with or not a beneficiary of a social security program (health insurance) * subject deprived of liberty (e.g. prisoners) * subject with positive infectious markers for hiv1, hiv2, hbc or hbv exclusion criteria for subjects with cystic fibrosis: * any pathology requiring a treatment or a pathology not requiring treatment but with clinical significance according to the investigator
transdermal estrogen in women with anorexia nervosa

Conditions: Anorexia Nervosa

Summary: randomized, placebo-controlled study investigating the use of physiologic, transdermal estrogen for low bone mass in adult women with anorexia nervosa.

anorexia nervosa is a prevalent psychiatric with a lifetime prevalence of up to 2.2%. among the many medical co-morbidities associated with anorexia nervosa, the most common is significant bone loss, which can persist despite weight recovery. nearly 90% of women with anorexia nervosa have osteopenia and this low bone mass is associated with an increased fracture risk. nearly 30% of women with anorexia nervosa report a history of a fracture and a prospective study demonstrated a 7-fold increased risk of fracture in women with anorexia nervosa compared to age-matched controls. because anorexia nervosa is a chronic disease that can persist despite psychiatric and nutritional counseling, the bone loss and increased fracture risk can persist and lead to lifelong morbidity. therefore, finding a treatment for bone loss associated with anorexia nervosa is of critical importance. this 18-month randomized, placebo-controlled study will investigate in women (ages 20 to 45 years old) with anorexia nervosa whether treatment with transdermal estrogen replacement will increase bone mineral density (bmd).

Eligibility criteria:
inclusion criteria: 1. female 2. 19-45 years of age 3. dsm-5 psychiatric criteria for anorexia nervosa 4. \<85% of ideal body weight as defined by the 1983 metropolitan life insurance height and weight tables 5. amenorrhea 6. t-score of \< -1.0 at spine or hip exclusion criteria: 1. diseases known to affect bone metabolism, including untreated thyroid dysfunction, vitamin d deficiency, cushing's syndrome, diabetes mellitus or renal insufficiency (egfr \< 60) 2. personal history of venous or arterial clot 3. history of stroke or myocardial infarction 4. history of hypercoagulable disorder 5. personal history or history of a first-degree relative with breast cancer 6. history of hereditary angioedema 7. any medication known to affect bone metabolism, including systemic glucocorticoids within three months of the baseline visit, depot medroxyprogesterone within 6 months of the baseline visit, oral bisphosphonates within one year of the baseline visit or iv bisphosphonates within three years of the baseline visit 8. bone fracture within the prior 12 months 9. serum potassium \ 3 times the upper limit of normal or hemoglobin \< 10 g/dl 10. fasting serum triglyceride level \> 150 mg/dl 11. pregnant or breastfeeding (or desiring pregnancy within the next 18 months) 12. active substance abuse 13. elevated pth level 14. 25-oh vitamin d level \< 20 ng/ml 15. low phosphorus level

Keywords: bone mineral density estrogen
a observational study of assessment and treatment adequacy of emergency cancer pain in tertiary cancer hospital

Conditions: TO STUDY EMERGENCY CANCER PAIN PATTERNS AND TREATMENT ADEQUACY.

Summary: emergency cancer pain management has been inconsistent and inadequate across the globe. this study aims to know emergency room cancer pain patterns and treatment adequacy in tertiary care cancer hospitals.


Eligibility criteria:
inclusion criteria: * adult cancer patients reporting to emergency room with complaints primarily of pain exclusion criteria: * patients below 18 years of age and patients with incoherent behaviour.
effect of oral cinnamon intervention in metabolic syndrome

Conditions: Metabolic Syndrome

Summary: this double blind placebo control study with supplementation of oral cinnamon is being conducted to test the hypothesis that in subjects with metabolic syndrome oral cinnamon may lead to improvement in body composition and metabolic parameters.


Eligibility criteria:
inclusion criteria: 1. subjects aged between 25 -65 years 2. subjects identified with any three of following: 1. fasting blood glucose ≥100 mg/ dl 2. waist circumference ≥ 90 cm ( males) ≥ 80 cm (females) 3. triglycerides ≥ 150 mg/dl 4. high density lipoprotein cholesterol ≤ 40 mg/dl ( in males) , ≤ 50 mg/dl (in females) 5. blood pressure systolic bp ≥ 130 mm hg 6. diastolic bp ≥ 85 mm hg 3. subjects who were willing to participate in the study. 4. subjects, if on medication for high blood pressure were stable and there was no change in the dosage for the past 3 months. exclusion criteria: 1. subjects suffering from other chronic diseases and metabolic complications such as cardiovascular disease, diabetes, renal disease, myocardial infarction and other endocrine disorders. 2. subjects who were allergic to wheat flour and cinnamon. 3. subjects who were on medication of anti dyslipidemic or hypoglycemic drugs. 4. subjects who had undergone bypass procedure. 5. subjects suffering from any debilitating disease such as tuberculosis, hiv etc. 6. subjects suffering from uncontrolled hypothyroidism/ hyperthyroidism 7. pregnant and lactating mothers
profiling of post covid-19 infection patients: an online survey

Conditions: Covid19

Summary: the aim of this study is to explore the relation between indicators of central sensitisation, quality of life and functional status in patients post covid-19 infection.


Eligibility criteria:
inclusion criteria: * male and female adults who were previously infected with covid-19
non-missile penetrating head trauma,cases registry in sohag university hospital

Conditions: Head Injuries With Non Missile Penetrating Objjects

Summary: a retrospective study was done in neurosurgery trauma unit, sohag university. eighteen patients reported with different mechanisms of trauma. all patients clinically tested involving neurological evaluation. computed tomography brain was done for them at the time of admission. cautious removal of the penetrating object with local debridement of surrounding tissues including skin, skull, dura and brain tissue and watertight closure of the dura should be done. patients transferred to the intensive care unit (icu) for 48 - 72 hours.

traumatic intracranial penetration of foreign non-missile object rarely occurs. early mortality may be caused by hemorrhages, major vascular injury or contusions; while epileptic seizures and infections are among the possible complications in later stages. complete excision of the foreign object should be done for all patients and any dural and/or vascular injuries should be repaired during surgical treatment. neurological level, hemodynamic and respiratory status at hospital admission, type of penetrating the object, pupil size, and reactivity, as the ct findings, all these factors will affect the prognosis so they should be evaluated carefully before the decision of the line of management. intracranial infection, csf leak and recurrent attacks of convulsions are the most common complications. our goal in this study to report cases with non-missile penetrating head injuries and evaluate the possible predictive factors in a series of 18 patients sustaining penetrating head injuries, admitted to our hospital over a period of 2 years, to be used as a guide for the surgical management.

Eligibility criteria:
inclusion criteria: * any patient with penetrating head trauma exclusion criteria: * missile penetrating head injuries

Keywords: penetrating brain trauma (pbt),traumatic brain injury (tbi), intensive care unit, non missile.
pre-approval single-patient expanded access for abrocitinib (pf-04965842)

Conditions: Severe Uncontrolled Atopic Dermatitis

Summary: provide pre-approval single patient expanded access (compassionate use) of abrocitinib for patients with severe uncontrolled atopic dermatitis

in expanded access, treating physicians are the sponsor. expanded access requests from treating physicians may be submitted at www.pfizercares.com ; availability will depend on location/country.

Eligibility criteria:
must have severe uncontrolled atopic dermatitis refractory to other available treatments

Keywords: atopic dermatitis ad atopic eczema jak inhibitors
a dose-finding study in japanese patients to evaluate the effect of obicetrapib as an adjunct to stable statin therapy.

Conditions: Dyslipidemia; Hypercholesterolemia; High Cholesterol

Summary: this study will be a placebo-controlled, double-blind, randomized, phase 2 dose-finding study in japanese patients to evaluate the efficacy, safety, and tolerability of obicetrapib as an adjunct to stable statin therapy.

this study will be a placebo-controlled, double-blind, randomized, phase 2 dose-finding study to evaluate the efficacy, safety, and tolerability of obicetrapib as an adjunct to stable statin therapy in japanese patients. the screening period for this study will take up to 2-weeks. afterwards, patients will be randomized to placebo, 2.5 mg obicetrapib, 5 mg obicetrapib or 10 mg obicetrapib for an 8-week treatment period. after the treatment period, patients will continue for a 4-week safety follow-up visit.

Eligibility criteria:
inclusion criteria: * ldl-c \> 70 mg/dl and tg \< 400 mg/dl, * treated with a stable statin therapy; atorvastatin 20/40 or simvastatin 10/20 exclusion criteria: * bmi \> or =35 kg/m2 * significant cardiovascular disease * hba1c \> 10% * uncontrolled hypertension * active muscle disease * gfr \< 60 ml/min * hepatic dysfunction * anemia * existing cetp deficiency * history of homozygous familial hypercholerstrolemia * history of malignancy * alcohol abuse * treatment with investigational product * treatment with pcsk9 * clinically significant condition * known cetp inhibitor allergy

Keywords: obicetrapib statin ldl-c cholestero l atherosclerosis
the effect of reiki applicatıon on sleep and qualıty of life in epılepsy patıents

Conditions: Sleep; Life Quality

Summary: after the general period of positive social adjustments, epilepsy is in a high life cycle to control seizures. during seizures in epilepsy, patients' quality of life and antiepileptic life span can be seen in daily life such as daily life and daily awakenings. reiki, which has been proven by studies in health problems such as fatigue and pain; an energy that can be unblocked or applied in a non-applicable way can benefit from a therapy that can be applied by touch or remotely, without negative effects. in the literature, reiki applied to epilepsy patients has sleep and quality of life. this thesis is planned to do research on sleep and living areas of reiki applied to epilepsy patients.

this research; it will be carried out on a voluntary basis with the treatment of 60 patients with epilepsy, 30 of which will be tested, 30 of which will be comprehensive, from the university of fır hospital neurology clinic polyclinic and those over 18 years of age, who can communicate adequately, who have psychiatric problems, who are in the last six body mind, who can control the phone, who will come to the scale, who will come to sleep. the study will be a pretest-posttest controlled group study. data; patient information form will be collected with pittsburgh sleep quality scale, quality of life in epilepsy scale. the control method will not interfere. if we try, first the application places and the way of doing it will be shown. administration through 4 weeks, first consecutive week; 1 session face-to-face 30-45 minutes, then 3 sessions of 21 minutes of training, 2 sessions of 21 minutes of training in the other 3 training courses, a total of 4 weeks 10. for face-to-face reiki; a room will be used inside the hospital. reiki to 7 different chakras to be taken in the first session. for the other sessions, before the application, all will be called and informed about the reiki will be sent, and then he will apply reiki from a distance for 21 minutes by using the training and reiki symbols. the scales will be reapplied by the researcher, either face to face or face to face, during the experiment and 4 weekends to be controlled. finally, there will be a significant difference between the pretest and the son test.

Eligibility criteria:
* be over 18 years old * ability to communicate adequately * absence of psychiatric problems * not having received body-mind therapy (yoga, reiki, massage, meditation) in the last six months * volunteering to participate in the research * own a phone * having a scale score of greater than 5 according to the pittsburgh sleep quality scale * not using sleeping pills 4.4.2. exclusion criteria from research * being under the age of 18 * having trouble communicating * having a psychiatric problem * having received body-mind therapy (yoga, reiki, massage, meditation) in the last six months * not being willing to participate in the research * not having a phone * having a scale score of less than and/or equal to 5 on the pittsburgh sleep quality scale * using sleeping pills
evaluation of the efficacy and safety of laxymig® as prophylactic treatment in patients with migraine

Conditions: Migraine With Aura; Migraine Without Aura

Summary: the purpose of this study is to evaluate the efficacy and safety of laxymig® er compared with placebo in prophylactic monotherapy treatment of migraine headache.

the purpose of this study is to evaluate the efficacy and safety of laxymig® er compared with placebo in prophylactic monotherapy treatment of migraine headache. four weeks baseline, following with 12 weeks treatment phase. subjects migraine are recorded by diary cards and re-evaluated by the investigator. subject will have visit every 4-week (+/- 7 days).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of migraine with or without aura (typical aura with migraine headache) * subjects who had an average of two or more migraine frequencies per month during the 3 months before screening exclusion criteria: * female subjects who are pregnant, lactating * chronic daily headache * previous treatment with three or more migraine prophylaxis medications failed * subjects with hepatic disease whose liver enzymes are over 2 times of upper limit of reference or significant dysfunction * coexisting medical, neurological, or psychiatric disorder that may hinder the study according to the investigator's judgment

Keywords: migraine migraine prophylaxis
amniotomy for second-trimester pregnancy termination

Conditions: Abortion, Missed

Summary: the termination of abortion is an important issue that has many controversies. the most common time of serious abortion-related complications is the second trimester. missed abortion is one of the most common indications of termination of pregnancy in the second trimester. misoprostol and mifepristone are effective drugs for induction of abortion but these drugs are now expensive, and non-available in many developing countries. the effectiveness of foley's catheter balloon on cervical ripping for mid-trimester pregnancy termination has been proved before. it can effectually shorten the time of the expulsion of the fetus. amniotomy defines as an artificial rupture of the membranes; it is an ordinary obstetric practice used mainly in the induction of labor, with good results and less morbidity. the obstetricians used to combine amniotomy with other methods such as prostaglandins or oxytocin to induce labor in a woman with an unfavorable cervix. despite plenty of studies that investigated the role of amniotomy for induction of labor but the studies which addressed the role of amniotomy in the induction of second-trimester abortion are very scarce in the literature.


Eligibility criteria:
inclusion criteria: * women aged 18-40 years old. * women who are pregnant in singleton mid-trimester missed abortion (18-26 weeks). * bishop's score is ≤ 4. exclusion criteria: * women who delivered before by classic caesarian section or had a history of -myomectomy, hysteroscopic uterine surgery, or cervical surgery like conization. * women with multiple gestations. * women with ultrasonography evidence of low amniotic fluid volume. * women with rupture of fetal membranes. * women with evidence of low implanted placenta by ultrasound. * history or laboratory evidence of intra-uterine infection. * history is suggestive of latex allergy. * women with severe anemia, hypertension, diabetes, or with coagulopathy.
study of molecular response in adult patients on nilotinib with philadelphia chromosome positive chronic myelogenous leukemia (ph+ cml) in chronic phase and a suboptimal molecular response to imatinib

Conditions: Chronic Myelogenous Leukemia - Chronic Phase

Summary: this exploratory study will evaluate the change in molecular response in chronic myelogenous leukemia - chronic phase patients with a complete cytogenetic response and have a suboptimal molecular response to imatinib


Eligibility criteria:
select inclusion criteria: * male or female patients ≥ 18 years of age with a confirmed diagnosis of ph+ cml-cp and ccyr * a suboptimal molecular response to imatinib defined as: * group 1: treated with 1 year of imatinib, complete cytogenetic response (ccyr) but no major molecular response (mmr) (bcr-abl levels \>0.1%is); * group 2: no specific duration of imatinib required, achieved ccyr but has \>1 log increase in bcr-abl transcript levels * adequate end organ function * patients must have had an imatinib washout period of at least 3 days and not to exceed 7 days prior to the first dose of nilotinib. group 1 patients must have been treated with imatinib for at least 1 year. there was no imatinib treatment duration requirement for group 2 patients. * for group 1, patients were eligible for screening if they were treated with an imatinib dose of at least 400mg daily. dose reduction could have occurred as long as the minimum dose was 300mg daily and the reduction lasted ≤ 28 days. the patient was required to be on 400 mg daily (or a higher dose) of imatinib for at least 6 consecutive months leading up to screening for this study. * for group 2 patients, dose reduction while on imatinib could have occurred as long as the minimum dose was 300 mg daily, and the reduction lasted ≤28 days. select exclusion criteria: * prior accelerated phase or blast crisis cml * patients achieving prior ccyr on imatinib who lost cytogenetic response prior to entering study * previously documented t315i mutations * prior therapy with any other tyrosine kinase inhibitor except imatinib * patients with contraindications to receiving nilotinib, including concomitant medications

Keywords: leukemia chronic myelogenous leukemia chronic phase molecular response nilotinib enabl
cone-beam ct in the diagnosis and surgical treatment of otosclerosis.

Conditions: Otosclerosis; Cone Beam Computed Tomography; Stapes Fixation

Summary: our studies will systematically investigate and establish evidence on whether cone-beam computed tomography (cbct) of the temporal bone could be used in the diagnosis and treatment of otosclerosis and in the post-operative follow-up after stapedotomy.

cone-beam ct has a high resolution and a low effective radiation dose to the patient when compared to conventional ct-scans. surgical treatment of otosclerosis is primarily by stapedotomy. the decision of surgical treatment is currently based on the history, clinical examination, and audiological tests, but stapes fixation can only be confirmed per-operatively. this protocol includes the following overall aims for the following studies: * to establish the diagnostic precision of clinical cbct in diagnosing otoslcerosis, i.e., the sensibility and specificity for our scanning protocols (n=50). * to determine if cbct can support the clinicians' decision making in the diagnosis of otosclerosis (n=100). * to assess the value of cbct in the planning of stapes surgery. two groups will be established: cbct-based pre-operative planning (e.g., prothesis parameters and anatomic landmarks) and no-planning (standard treatment). patients will be allocated by 1:1 randomization (n=75). * to assess the value of cbct in the post-operative follow-up of 2-3 weeks, 2-3 months, and 12 months. follow-up includes a clinical examination, audiometry, cbct (block-randomized), and patient questionnaires (audiometry and patient questionnaire not at the "2-3 weeks" control) (n=75). * to assess the value of pre-preoperative cbct on post-surgical result at follow up (2-3 weeks, 2-3, months and 12-months) (n=75).

Eligibility criteria:
inclusion criteria: * adults (\>18 years of age). * referred to our department suspected for otosclerosis. * consents to participation in the project. exclusion criteria: * a history of surgical treatment for otosclerosis (ipsilateral ear). * a history of tympanoplasty type 2-4 (ipsilateral ear). * other competing middle-ear diseases (ipsilateral ear). inclusion and exclusion criteria for patients enrolled for post-surgical follow-up are the same as above in addition to: exclusion: - intraoperative findings not supporting otosclerosis.

Keywords: otosclerosis stapedotomy cone beam ct