Kornimate/medical-research-clean huggingface dataset:
heart rate variability and orthostatic hypotension in stroke patients evaluated by intelligent biosensor system

Conditions: Cerebrovascular Accident

Summary: this research investigated the heart rate variability (hrv) and stroke patients' orthostatic hypotension in hospitalized stroke patients accompanied with dizziness at varied tilting angle controlled by tilting table with intelligent biosensor.

stroke patients readily accompany with the occurrence of orthostatic hypotension. to earlier predict patients occurring dizziness during the tilt table test, this study utilized a self-developed integrated intelligent biosensor system to assist clinical staff efficiently and immediately assessing stroke patients with orthostatic hypotension. further purposes were to survey the relationship between the orthostatic hypotension and heart rate variability (hrv) and find the predicted models of orthostatic hypotension.

Eligibility criteria:
inclusion criteria: * patients who are first time to get stroke. exclusion criteria: * unstable physiological conditions, serious joint spasticity, use cortisol or calming drugs, other neurological diseases

Keywords: heart rate variability orthostatic hypotension stroke integrated intelligent biosensor system
effectiveness of self-myofascial release combined with biofeedback and electrical stimulation for the management of mfpp

Conditions: Myofascial Pelvic Pain

Summary: myofascial pelvic pain (mfpp) caused by myofascial trigger points (mtrps) is a major contributor of female chronic pelvic pain. however, the effect of the patient's self-myofascial release (smfr) is not clear. current study is to investigate the effect of smfr combined with biofeedback and electrical stimulation (bes) therapy compared with bes alone in patients with mfpp.

68 patients was enrolled and randomly allocated into two groups: bes-smfr group (n=34) and bes group (n=34). every patient received 4 weeks treatment, and was evaluated at baseline (t0), 4-week post-intervention (t4) and 12-week follow-up (t12). the primary outcome was pain intensity. the secondary outcomes were degree in activation of mtrps, surface electromyography (semg) levels, and patient global impression of improvement (pgi-i).

Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 years; 2. presence of persistent chronic pelvic pain ≥ 4 points on a 10 points numeric rating scale for at least 3 months; 3. at least one active mtrp in one of muscle group including obturator internus, levator ani, piriformis, coccygeus on pelvic examination. exclusion criteria: 1. diseases of the urinary, genital, colorectal systems; 2. prolapse of the pelvic organ; 3. a history of pelvic rehabilitation within the 3 months prior to study; 4. psychiatric disorders; 5. pregnancy; 6. breastfeeding.
risk factors of failure of conservative treatment in acute non complicated appendicitis

Conditions: Conservative Management

Summary: from this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the nom of uncomplicated acute appendicitis. these include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, tlc cells/dl, crp mg/l, appendix diameter mm, modified alvarado score , and adult appendicitis score .

expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . it is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Eligibility criteria:
inclusion criteria: * male or female patients é diagnosis of acute appendicitis . * patients with ages: from 16 to 60 years old. exclusion criteria: * complicated aa (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor). * inflammatory bowel disease. * inability to co-operate and give informed consent. * diffuse peritonitis. * antibiotic documented allergy \& allergy to contrast media . * patients with serious comorbid conditions dm \& renal insufficiency, serum creatinine \> 150 μmol/l . * pregnant \& lactating patient. * patients with bleeding diathesis and those on anticoagulants. * patients with advanced malignancies \& patient on immunosuppressive drugs . * patients with previous appendectomy. * extreme of age.

Keywords: appendicitis
outcomes and user acceptance of the intellivue alarm advisor software (europe)

Conditions: Clinical Alarms

Summary: this clinical study will be conducted as a comparative study focusing on usability and efficiency by comparing alarm burden pre- and post-implementation of an "alarm advisor software".

in a first phase of data collection (pre-implementation) all alarms of an intensive care unit population are recorded. in an interim period an alarm advisor software will be introduced to the unit. in a second phase (post-implementation) the same set of alarm data will be recorded. the "alarm advisor" software can identify alarms based on criteria set by the medical staff and provide hints to reduce alarms and alarm nuisance (e.g. by proposing adjustments of alarm limits). the effect of reduction of recurring nuisance alarms through the implementation of the alarm advisor shall be evaluated.

Eligibility criteria:
inclusion criteria: * patients admitted to the intensive care unit during the study period exclusion criteria: * none

Keywords: alarms alarm fatigue alarm nuisance alarm reduction patient monitoring intensive care
the use of the uroshield device in patients with indwelling urinary catheters

Conditions: Urinary Tract Infection

Summary: according to the israeli ministry of health requirement, this study was designed to evaluate the efficacy of the uroshield system is patients that require urinary catheterization. this was designed to compare standard treatment (urinary catheter alone) with the uroshield treatment in occurrence of catheter associated urinary tract infection, pain, discomfort, biofilm prevention and trauma.

this study is aimed at assessing the effectiveness of the nanovibronix™ uroshield™ system in comparison to urinary catheter alone in patients requiring urinary catheterization. 1. primary objectives * to observe the effect of uroshield in reduction of patient's complaints relating to indwelling urinary catheters * pain * discomfort * to observe the effect of uroshield in the reduction/prevention of biofilm * to observe the effect of uroshield on the occurrence of bacteriuria and/or uti's on patients with indwelling urinary catheters 2. safety objective to assess the safety parameters of the uroshield system 3. secondary objectives * to observe the effect of uroshield in reduction of foley catheter related pain medication in patients with indwelling urinary catheters * to observe the effect of uroshield in reduction of antibiotic medication in patients with indwelling urinary catheter * to observe the effect of uroshield on the clogging of urinary catheter when used chronically and the need to replace the catheter * to observe the effect of uroshield on the decrease of tissue damage of patients with indwelling urinary catheters by measuring cell count before and after removal of catheter

Eligibility criteria:
inclusion criteria: * hospitalized patients age 18 years or older * patients requiring or having catheterization for more than 24 hours * patient able, agrees and signs the informed consent form exclusion criteria: * pregnant or breastfeeding women. women of child bearing potential will perform a pregnancy test before inclusion into the study * presence of any clinically relevant known urinary tract infection * patient with condition who is not expected to survive the study period * known hiv positive * patient has any condition, which precludes compliance with study and/or device instructions. * patient is currently participating in another clinical study. * known allergy to latex
high-flux hemodialysis versus hemodiafiltration for end-stage renal disease

Conditions: Chronic Kidney Failure

Summary: this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on small and moderate molecule substances clearance. meanwhile, this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on cardiac function. in this self matching study, participants will receive high-flux hemodialysis compared to hemodiafiltration.

hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water, is one of the most commonly replacement therapy. hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.

Eligibility criteria:
inclusion criteria: 1. subject has end-stage renal disease. 2. subject has been on regular dialysis treatment for at least 6 months. 3. subject has autologous vascular access. 4. subject is offered thrice weekly hemodialysis. 5. subject is offered 4 hours duration hemodialysis. exclusion criteria: 1. infectious disease 2. poor echocardiographic window that was unsuitable for interpretation

Keywords: hemodialysis hemodiafiltration end-stage renal disease
exercise tolerance after venous recanalization for post-thrombotic syndrome

Conditions: Post Thrombotic Syndrome; Venous Thromboses; Claudication, Intermittent

Summary: post-thrombotic syndrome (pts) is the most frequently observed chronic complication of deep vein thrombosis (dvt), with an estimated cumulative incidence of 20-50%. endovascular venous recanalization with angioplasty and stenting of obstructive lesions is the recommended treatment option to reduce or correct the symptoms of dvt. however, its impact on the physical capacity and breathlessness of patients has not been fully demonstrated. the heterogeneous evidences of clinical improvement is probably related to the presence or absence of collateral veins developed in these patients with proximal venous obstruction (iliac or iliofemoral with or without inferior vena cava involvement), which ensure the cardiac venous return. the aim of this study is to compare changes in maximal oxygen uptake after endovascular venous recanalization in dvt patients and to evaluate the hemodynamic, respiratory and muscular improvement induced by the restoration of venous flow in the occluded segments.


Eligibility criteria:
inclusion criteria: * patient eligible for endovascular treatment for post-thrombotic syndrome in a chronic context (6 months after the occurrence of thrombosis, without time limit), after validation of the indication during a monthly medical-radiological pcr (st eloi vascular medicine team and vascular radiologist performing the endovascular treatment) * age \>= 18 years exclusion criteria: * contraindication to the performance of a maximal effort test on a cyclo-ergometer * refusal of consent after information * adult protected by law (guardianship, curatorship) * pregnant or breastfeeding woman * patient not affiliated to a social security system or not benefiting from such a system

Keywords: iliac vein inferior vena cava exercice tolerance cardio-pulmonary exercice testing muscle physiological testing
a new method of muscle strength testing using a quantitative ultrasonic technique and a convolutional neural network

Conditions: Muscle Disorder

Summary: in addition to muscle thickness and average echo intensity, this study aimed to use quantitative ultrasonic technology to increase the number of related parameters of power doppler ultrasonography measured to describe the number, quality, and recruitment level of muscles. in addition, this method was compared with the existing muscle strength testing methods. image recognition was performed using the traditional multivariate linear regression statistical method and the ai convolutional neural network algorithm to investigate the application of quantitative ultrasonic technology for direct evaluation of muscle strength in clinical practice.

collection of all quantitative ultrasonic data was performed by one ultrasound physician. the aixplorer® series color ultrasonic diagnostic instrument of supersonic imagine (france) and an l15-4 linear array probe were used. the medial head of the quadriceps muscle was measured. the subjects wore short pants that settled above the knees. tight pants were avoided to prevent impaired venous return, which can affect the power doppler ultrasonography result. the subjects did not exercise within half an hour before testing. two-dimensional images of the subjects' muscles were collected in a quiet resting state and used to measure muscle thickness and the average echo intensity. the power doppler images were used to measure the level of muscle hyperemia. the measurements were performed in the 0° knee extension position and the most prominent part of the medial head of the quadriceps muscle was measured by the ultrasound physician using visualization. the probe angle was perpendicular to the trajectory of the muscle bundle, and the measurement was performed with the muscle in a relaxed state. after the measurements, the knee was restrained to complete the isokinetic muscle strength test. when testing of the last group was completed, the knee was released immediately. the two-dimensional image and the power doppler image at the same location were captured and the image acquisition time was no more than 3 s.

Eligibility criteria:
inclusion criteria: * no major complaints of muscle numbness, spasm, or atrophy, muscle-related physical activity impairment or joint swelling and pain * no obvious malformation in the lower limbs * no disease history in the musculoskeletal system, nervous system, and peripheral blood, * no history of severe trauma in the lower limbs * joint mobility and muscle tension met the thresholds of muscle strength assessments * no severe osteoporosis * no acute inflammation or acute bone fracture repair * between 18-55 years of age exclusion criteria: -
low-level laser in treatment of head and neck lymphedema: a pilot study

Conditions: Head and Neck Cancer; Lymphedema; Fibrosis

Summary: the purpose of this pilot clinical trial is to evaluate the feasibility of the use of low-level laser for head and neck cancer survivors with lymphedema.

primary aim: to determine the feasibility of the use of lllt for hnc survivors with lymphedema, specifically to 1) obtain recruitment estimates and determine barriers to recruitment; 2) identify barriers to implementation; 3) assess safety; and 4) evaluate patient satisfaction.

Eligibility criteria:
inclusion criteria: * \>18 years of age * completion of either postoperative radiation or chemoradiation therapy * no evidence of cancer * having head and neck external lymphedema * either completion of lymphedema therapy or not in active lymphedema therapy * ability to speak and read english * able to provide informed consent exclusion criteria: patients will be excluded if they have any of the following medical conditions that would prohibit the safe implementation of lllt: pregnancy; photosensitivity; chronic inflammatory diseases; venous thrombosis; history of severe trauma; medication that affects body fluid and electrolyte balance; use of high doses of non-steroidal anti-inflammatory drugs; or pre-existing skin rash, ulceration, open wound in the treatment area; and allergic and other systemic skin diseases.
individual closed-loop neuromodulation therapy for alzheimer's disease

Conditions: Alzheimer Disease; Mild Cognitive Impairment

Summary: the project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tacs) to study patients with symptoms of mild cognitive impairment which is likely due to alzheimer's disease or another form of dementia (ad-mci). patients will undergo an eeg and complete some questionnaires and computer tasks during each study visit. the project has the following aims and hypotheses: 1.) to determine the impact of closed-loop 40 hz tacs on the entrainment of natural gamma rhythms in patients with ad-mci, 2.) to determine the impact of closed-loop 40 hz tacs on cognitive performance in patients with ad-mci, and 3.) to assess the relationship between baseline neurodegenerative burden and impact of tacs. \[exploratory\]


Eligibility criteria:
inclusion criteria: * overall cognitive functional status consistent with amnesic mci (cdr 0.5) likely due to ad (ad biomarker supported) * 50-80 years of age * english native speakers exclusion criteria: * known presence of a structural brain lesion (e.g., tumor, cortical infarct) * acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure * active hematological, renal, pulmonary, endocrine or hepatic disorders * longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed * tacs contraindications (lesions in the scalp, history of seizures)
a pilot surveillance study to monitor natural killer cells and circulating tumor cells in women with previously treated non-metastatic triple negative breast cancer and women with previously treated non-metastatic breast cancer with a confirmed brca mutation.

Conditions: Triple Negative Breast Cancer; Natural Killer Cells; BRCA Mutation

Summary: the purpose of this research study is: * to test blood for the presence of tumor derived circulating tumor cells (ctcs) or circulating tumor dna (ctdna) using an investigational medical device called the liquidbiopsy®. using the liquidbiopsy® platform, recovered cells or dna can also be investigated to obtain genetic information that may be useful to treating physicians in understanding disease. * to test blood for natural killer cells (nk cells), which are part of the body's natural immune defense against tumors. a device called the nk vuetm kit will be used for this test. the liquidbiopsy® is a new investigational device. an investigational device is one that is not approved by the united states food and drug administration (fda). the nk vuetm kit is an investigational device in the united states but is approved in canada and south korea as a class ii device. if a tumor is present, very tiny numbers of tumor cells or the contents of these tumor cells can get dislodged from the tumor and swept into the bloodstream. the liquidbiopsy® device is able to purify the tiny numbers of tumor cells or ctdna in the blood. even if a tumor is too small to be found by other means such as an x-ray, it is possible that ctdna or ctcs may be found in the blood. genetic information can then be recovered from these cells or dna to look for genetic changes that are related to the abnormal growth in a tumor. this will potentially allow researchers to study tumor cells or tumor dna from a blood sample instead of a biopsy sample. this may influence cancer diagnosis, treatment and drug selection in the future. nk cells occur naturally in the body and kill tumor cells. this study will measure the activity of the nk cells in blood. a strong correlation between low nk cell activity and increased circulating tumor cells in blood has been reported.


Eligibility criteria:
inclusion criteria: * signed informed consent form. * female. * over 18 years of age. * previously treated non-metastatic triple negative breast cancer or women with previously treated non-metastatic breast cancer with a confirmed brca mutation who have completed therapy within three years of enrollment in this study. * subject may be invited to annual review of the subject information and donation schedule by email or mail follow up for five years after sampling. * subject provides written authorization for use and disclosure of protected health information (phi). exclusion criteria: * any conditions inappropriate for blood drawing. * known active viral or bacterial infection at time of blood draw. * known hiv, hepatitis b, or hepatitis c infection.

Keywords: triple negative breast cancer breast cancer natural killer cells brca mutation
the prescriptive validity of a novel fall risk clinical prediction rule for people with copd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this study has 3 objectives: (1) demonstrate the effectiveness of balance training for people with copd, (2) determine which patients with copd respond best to balance training, and (3) calculate clinically meaningful changes in balance for patients with copd.

after receiving a detailed explanation of the study, including its risks and benefits, and providing informed consent, patients will be screened for eligibility criteria during a single 75-minute evaluation for participation in a physical therapy based pulmonary rehabilitation program. those meeting eligibility criteria will be randomly assigned in blocks of four (by clinical site) in a single-blind manner (patients) in a 1:1 ratio to either balance training or a breathing and stretching exercise program. both groups will receive respiratory muscle stretch exercises, aerobic exercise, strength training, and fall prevention education. the intervention phase will last 8 weeks, with patients being seen 3 times per week for 75 minute sessions supervised by a physical therapist or physical therapist assistant.

Eligibility criteria:
inclusion criteria: * having reported a fall in the past 5 years, or a near fall in the past year, or a score ≥ 9 on the short version of the falls efficacy scale - international version * age ≥ 60 years * both sexes * spirometrically-confirmed copd of all disease severity stages * being independently ambulatory with or without a gait aid * medical clearance by a physician to participate in pulmonary rehabilitation * provision of informed consent. exclusion criteria: * having suffered a recent, severe copd exacerbation (recent is 30 days or less prior to the study baseline) * participation in a formal exercise program in the three months prior to the study baseline * an inability by the patient to complete all study testing due to physical, psychological, communication-barrier, or other unanticipated reasons.

Keywords: balance falls fall risk aerobic exercise strength training fall prevention stretching exercise breathing exercise randomized controlled trial clinical prediction rule minimal clinically important difference