Kornimate/medical-research-clean huggingface dataset:
evaluation of remineralization potential of self assembling peptide combined with fluoride

Conditions: Caries; Initial

Summary: self-assembling peptide (p11-4) exhibited an outstanding ability for biomimetic re-mineralization of incipient enamel carious lesions. it creates a 3d matrix within the subsurface of carious lesions, allowing de novo formation of hydroxyapatite crystals, thus enabling guided enamel regeneration of the demineralized enamel structure. addition of fluoride to p11-4 may have a synergistic effect on the remineralization potential.

this study is a randomized clinical trial, with parallel study design, 1:1 allocation ratio and superiority framework. the aim of the current trial is to evaluate remineralization potential of p11-4 combined with fluoride compared to fluoride varnish in management of incipient white spot carious lesions. progress of the lesions will be assessed using laser fluorescence (diagnodent).

Eligibility criteria:
inclusion criteria: * active carious white spot lesions. * patient compliance. * controlled oral hygiene condition. exclusion criteria: * participant in another trial. * non carious lesions. * systemic diseases or concomitant medication affecting salivary flow. * cavitation of carious lesions. * parafunctional habits. * pregnancy.
prevalence of vitamin d deficiency in type 1 diabetes mellitus and effect of supplementation on insulin requirements

Conditions: Type 1 Diabetes Mellitus

Summary: our objective is to demonstrate that providing supplemental vitamin d to children with new onset dm will significantly decrease the levels of hba1c and insulin requirement by the following methods. 1. identify how often vitamin d levels are low in patients with new onset type 1 diabetes mellitus (dm). 2. record the hemoglobin a1c (hba1c) level (which reflects the average blood sugar level over the past few months) and document insulin requirements before and after vitamin supplementation is given. hypothesis: maintaining vitamin d levels \>30 ng/ml will decrease hba1c and insulin requirements.

new onset type 1 dm patients who present at william beaumont hospital, royal oak or to the pediatric endocrine clinic will be approached about the study at their presentation and time will be given for the patient and family to discuss and ask questions regarding the study. patients will then be enrolled following informed consent. glucose levels and insulin requirements will be monitored continuously from the faxed weekly logbooks from the point of diagnosis for 3 months (as standard practice for all newly diagnosed diabetic patients in our clinic). at the baseline visit a vitamin d level will be drawn and frozen for 3 months prior to processing. .after 3 months vitamin d, calcium, alkaline phosphatase, phosphorus and other standard of care lab draws will be done. approximately an additional 3 tsp of blood will be taken. all female subjects of child bearing potential will have a pregnancy test done. emla cream to anesthetize the area will be used prior to blood draw. a vitamin d level of \<30 ng/ml is considered insufficient and the patient will then be given vitamin d supplement. the vitamin d level, calcium, alkaline phosphatase and phosphorus will be rechecked at 6 months (additional 3 tsp of blood) . glucose levels and insulin requirements will be monitored continuously from the faxed weekly logbooks again for another 3 months.

Eligibility criteria:
inclusion criteria: * newly diagnosed type i dm. * age \<18 years exclusion criteria: * pregnancy

Keywords: diabetes type i newly diagnosis type i diabetes mellitus
a randomized controlled trial of vsl#3 for the prevention of endoscopic recurrence following surgery for crohn's disease.

Conditions: Crohn's Disease; Inflammatory Bowel Disease

Summary: this randomized placebo-controlled double-blind, multi-centre trial will determine the efficacy of the probiotic vsl#3 in the prevention of crohn's disease development following surgical resection and re-anastomosis. a total of 120 patients will be randomly assigned in a 1:1 ratio to receive vsl#3 or placebo for 90 days. patients who respond to study treatment, as defined by the absence of a severe endoscopic recurrence at day 90, will be offered open-label vsl#3 for an additional 9 months.


Eligibility criteria:
inclusion criteria: 1. subjects 16 years of age or older 2. diagnosis of crohn's disease 3. resection of ileocolonic crohn's disease and small bowel to colonic anastomosis within 30 days of randomization 4. able to provide informed written consent 5. women of child-bearing potential with a negative serum pregnancy test, and/or use of effective contraception exclusion criteria: 1. use of perioperative steroids in tapering doses and anti-diarrheal agents 2. treatment with a tnf-antagonist in the 8 weeks prior to resection 3. clinically significant crohn's disease elsewhere in the gi tract 4. clinically documented short bowel syndrome 5. serious disease other than crohn's disease 6. impaired liver or renal function 7. history of cancer with less than 2 years disease-free state 8. abnormal laboratory values 9. alcohol or drug abuse 10. some psychiatric conditions 11. patients using other study medications 12. patients who are unable to attend study visits or comply with study procedures 13. positive pregnancy test
the prognostic value of pupil near response in uws patients

Conditions: Vegetative State

Summary: previous studies suggest that the stimulus of pupil near response (pnr) may be a conscious perception of a blurred image. moreover, pnr is a reflex that can be objectively observed and with no motor output, suggesting it might be a more convenient index for consciousness evaluation and consciousness recovery in patients with disorders of consciousness (doc). we thus hypothesized that pnr+ patients (patients show pnr during the assessment) would have better prognosis than pnr- patients (patients fail to show pnr during the assessment).based on this hypotheis, researchers will assess pupil near response in patients with unresponsive wakefulness syndrome (uws) and compare the prognosis difference between pnr+ patients and pnr- patients to assess its prognosis value.

pnr assessments will be conducted in patients with unresponsive wakefulness syndrome (uws) diagnosed by the coma recovery scale-revised (crs-r).an objective index,the ratio of pupillary constriction (pupil diameter change after a stimulus presentation divided by the resting state pupil diameter) will be used as the measure of pnr's presence (positive results indicate the presence of pnr,whereas negative results indicate the absence of pnr).according to the presence of pnr,patients will be divided into 2 groups,one includes patients who show pnr during the pnr assessment (pnr+),the other includes patients who fail to show pnr during the pnr assessment(pnr-).3 months later,a follow-up will be conducted to obtain their prognosis in the form of another crs-r assessment.patients diagnosed as minimally conscious state (mcs) will be considered as favourable prognosis,patients diagnosed as uws will be considered as unfavourable prognosis.their prognosis difference will then be compared to see pnr's effect on their prognosis (consciousness recovery). and for they couldn't show conscious visual behaviors (visual behaviors in crs-r which indicate mcs) in the first crs-r,their difference between visual prognosis (difference between each group's proportion of patients showing conscious visual behavior diagnosed by crs-r in the follow up) will be compared to see pnr's capability to predict prognosis in patients without voluntary eye movements (conscious visual behaviors in crs-r require voluntary eye movements). researchers expect to see the pnr+ group have better prognosis in both comparison.

Eligibility criteria:
inclusion criteria: * unresponsive wakefulness syndrome (diagnosed by crs-r) * normal or corrected to normal vision before the incidence (myopia did not exceed 300 degrees fahrenheit, farsightedness was less than + 2.00 d) * positive pupil light reflex. exclusion criteria: * nystagmus and drooping eyelids * unstable vital signs * under sedation during pnr test.

Keywords: disorders of consciousness unresponsive wakefulness syndrome pupil near response prognosis of consciousness recovery
the role of the thymus in myasthenia gravis

Conditions: Myasthenia Gravis; Thymoma

Summary: although the association between thymic hyperplasia / thymoma and autoimmune myasthenia gravis has been known for some time, the question of causality remains uncertain. recent research findings indicate, however, that especially in myasthenia patients with thymomas a non-physiological export of naive cd4 + t-cells can take place by the tumour and this could possibly play an important role in the pathogenesis of myasthenia gravis. the investigators want to analyse the functionality and specificity of t-cells generated in thymomas as well as the effect of thymectomy on the immune system.

on one hand we want to perform a detailed analysis of the t-cells generated in thymomas in terms of their functional capacity and their specificity. we will analyse blood and thymoma tissue of patients with myasthenia gravis with thymona, patients with myasthenia gravis without thymona, and patients with thymona without myasthenia gravis. hypothesis: the t-cells which are generated in the thymoma in thymoma-associated myasthenia gravis can be differentiated from t-cells which are generated in normal thymoma tissue with regard to functionality and t-cell receptor specificity. this non-physiological t-cell maturation might be the cause for the formation of auto-antibodies. on the other hand we want to examine the effects of thymectomy on the immune system in the context of myasthenia gravis. we will analyse blood and thymoma tissue of patients with myasthenia gravis with thymona, patients with myasthenia gravis without thymona, patients with thymona without myasthenia gravis and patients with cardiac, or thyroid surgery. hypothesis: 1. thymectomy in patients with myasthenia gravis leads to a reduced number of auto-reactive, e.g. acetylcholine receptor (ach-r)-specific t cells. in contrast, t-cells with other specifities, for example against cmv or tetanus, are not affected. 2. the non-physiological export of thymocytes from thymomas leads to a significant shift in leukocyte populations in peripheral blood.

Eligibility criteria:
inclusion criteria: * patients with compelling indications for thymectomy due to thymoma (with or without myasthenia gravis), or * patients with elective indication for thymectomy due to thymoma without myasthenia gravis * patients with indication for a heart or thyroid surgery, in which for op-technical reasons, a (partial) resection of the thymus is performed. * signed informed consent form * age \> 17 years exclusion criteria: * other immunological diseases such as rheumatoid arthritis, multiple sclerosis

Keywords: myasthenia gravis thymoma t-cells thymectomy
gebt telehealth administration usability study

Conditions: Gastroparesis

Summary: the purpose of this study is to establish the usability of a telehealth platform for the administration of gebt.

this study is intended to demonstrate that the 13c-spirulina gastric emptying breath test (gebt) can be successfully administered via a telehealth platform. telehealth administration of gebt is where a trained cairn employee uses a video link to remotely supervise the completion of the test request form, collection of breath samples, cooking and consumption of the test meal and return of breath samples by the patient to cairn.

Eligibility criteria:
inclusion criteria: * males and females, greater than or equal to 18 years of age at the time of signing the consent form, from healthy and intended use population (i.e. symptomatic for gastroparesis). women of childbearing potential must not be pregnant at the time of gebt administration. * ability to eat test meal and provide breath samples * access to a microwave oven at home * internet connection and telehealth accessible device (smart phone/tablet/computer with visual and voice capability) at home * environment to sit comfortably and quietly at home exclusion criteria: * history or physical exam suggestive of systemic disease such as pathophysiologic disorders such as renal failure, chronic heart disease, chronic respiratory disease, liver disease, or malabsorption syndrome * history of abdominal surgery except appendectomy * females on hormone replacement therapy other than birth control medications * receipt of any investigational drug within 4 weeks of the study * pregnancy * intolerance or allergy to any component of gebt meal * history of neurological or psychiatric disorders

Keywords: gastroenterology gastric emptying breath test telehealth
dialogical family guidance for neurodevelopmental disorders

Conditions: Family Dynamics

Summary: previous studies have highlighted the need to offer targeted effective interventions to strengthen the wellbeing of all family members in families with children with neurodevelopmental disorders (ndd). interventions for this target group requires development and research. a new family intervention, dialogical family guidance (dfg) was tested in this study. all families received dfg intervention ( 6 meetings ).

previous studies have highlighted the need to offer targeted effective interventions to strengthen the wellbeing of all family members in families with children with neurodevelopmental disorders (ndd). interventions for this target group requires development and research. a new family intervention, dialogical family guidance (dfg) was tested in this study. fifty families of children with ndd were randomized into two intervention groups. intervention group i were delivered dfg immediately, and intervention group ii were delivered dfg after three months. family functionality, health and support (fafhes), sdq and the 5-15-questionnaire and dfg parent questionnaires were used to collect data at baseline, after three and six months. fifty families were invited to the study. thirty-four families completed the study. a comparison were made between intervention group i and ii.

Eligibility criteria:
inclusion criteria: * clinical neurodevelopmental disorder diagnosis (eg adhd, asd, tics, language disorders) * the child is aged between 4-16 years * parent have adequate finnish language skills * parents are biological parents or step-parents of the child exclusion criteria: * the child is under 4 or over 16 years old * parents do not have adequate finnish language skills

Keywords: dialogical family guidance family health neurodevelopmental disorders
early versus delayed laparoscopic cholecystectomy for acute mild biliary pancreatitis: a prospective comparative study

Conditions: Biliary Acute Pancreatitis

Summary: the goal of this observational study is to evaluate the outcomes of early versus delayed cholecystectomy following mild biliary pancreatitis in nepalese patients.

this was a hospital-based prospective observational study performed at a tertiary academic center from september 2020 to august 2021. patients diagnosed with acute mild biliary pancreatitis according to the revised atlanta classification 2012 were enrolled from the emergency/outpatient department. detailed history taking and thorough general and systemic examinations were conducted. eligible patients were informed about treatment options (early vs. delayed lc) and provided informed written consent. randomization into "early" or "delayed" groups was performed, and detailed investigations were conducted. to avoid bias, randomization was accomplished by lottery method. in the early group, laparoscopic cholecystectomy was performed during the same admission, while delayed group patients underwent surgery after symptom resolution and readmission. surgeries were performed under general anesthesia with standard laparoscopic techniques with surgeons of equivalent qualifications. postoperative care included analgesics and antibiotics, with follow-up examinations and histopathological assessments conducted at specified intervals. oral intake and pain management protocols were implemented postoperatively, with patients monitored for recovery and instructed to return to normal activities after staple removal. patients were asked to complete a visual analog pain score (vas) from 0 (no pain) to 10 (intolerable pain) on the seventh postoperative day.

Eligibility criteria:
inclusion criteria: * patients (\>18 years of age) who presented with the diagnosis of acute mild biliary pancreatitis in our hospital were included after obtaining written consent exclusion criteria: * patients with severe sepsis, acute moderate and severe pancreatitis, immunocompromised conditions, biliary peritonitis, cholangitis, pregnancy, admission to the intensive care unit (icu) or high dependency unit (hdu) and those who declined to provide consent.

Keywords: biliary acute pancreatitis laparoscopic cholecystectomy outcomes
the relationship between allergic rhinitis and geographic tongue

Conditions: Allergic Rhinitis; Geographic Tongue

Summary: allergic rhinitis is a complex chronic inflammatory disease, it always presents with nasal obstruction, nasal itching, sneezing and runny nose. whether in adults or children, rhinitis is a complex disease. the prevalence of allergic rhinitis in taiwan is about 24-29%. taiwan is a developing country. it is a hot and humid country. in developing countries, industrialization, air pollution makes the constantly increasing number of patients with rhinitis. penghu in 1994 for children aged 7 to 14 by the study found that among 7599 people, 1766 people have allergic rhinitis, about 23.2%. allergic rhinitis is a complex chronic disease. so, it become a diagnostic challenge, its prevalence always underestimated. the prevalence of rhinitis has increased in recent years. the phenomenon of underestimate is caused by variety of personal and environmental factors. allergic rhinitis had increased direct and indirect social and economic burden. geographic tongue is a benign tongue performance. geographic tongue has been reported their relevance to allergy. geographic tongue is a chronic tongue situation. the causes of geographic tongue still remains unknown. allergic rhinitis is a diagnostic challenge to clinicians. the investigators hope that geographic tongue could play a role in the diagnostic of allergic rhinitis. the prevalence of geographic tongue in the united states is about 1.8%, white americans and mexicans have a higher incidence rate. this study will investigate the relevance between allergic rhinitis and geographic tongue. the investigators will analyze the relevant gender, age, severity of inspection reports. the research results wound provide an important reference to the diagnosis of allergic rhinitis.


Eligibility criteria:
inclusion criteria: * rhinitis and non-rhinitis patients * willing to complete the study * no limitation of tongue movement exclusion criteria: * more than 90 years old or younger than 20 years old * unable to complete the study

Keywords: allergy rhinitis geographic tongue
impact of preterm single donor milk in very low birth weight infants

Conditions: Infant, Premature, Diseases

Summary: human milk is the best source of enteral nutrition for the preterm infant. however during the infants first hours and days of life breastmilk from the own mother is usually not available. until may 2012 the practice in the neonatal division of the department of pediatrics /medical university vienna was to start with formula feedings within the first 6 hours of life of a premature infant and switch over to breastmilk as soon it was available. in june 2012 the investigators changed this feeding regimen and started to use single donor milk of mothers of preterm infants for the first hours and days of the preterm infants life. in a prospective observational study the investigators evaluated the impact of single donor milk from preterm infants on time to full enteral feedings, gastrointestinal tolerance and nec incidence in preterm infants with a birthweight below 1500 grams and a gestational below 32 weeks. data will be compared with a historical control group starting with preterm formula as source of enteral nutrition. the investigators hypothesize that starting enteral nutrition with single donor milk of mothers from preterm infants with shorten time to full enteral feedings.


Eligibility criteria:
inclusion criteria: * very low birth weight infants with a birthweight \<1500g * gestational age \<32 weeks * informed consent exclusion criteria: * major congenital malformations * systemic metabolic diseases * short bowl syndrome * gastrointestinal abnormalities * when preterm infant was transferred or discharged

Keywords: preterm single donor milk human milk very lo birth weight infants enteral feedings nec
effect of long-term exercise on haemostasis and inflammation in patients with coronary artery disease

Conditions: Coronary Artery Disease; Exercise; Inflammation; Hemostasis

Summary: introduction: regular exercise training improves prognosis in patients with coronary artery disease (cad). this study investigates whether the beneficial effects of exercise can be partly explained by favourable changes in haemostasis and inflammation. methods: 150 cad patients are randomised to a supervised long-term exercise program (3 months) or usual care. blood samples are obtained at baseline, 1.5 months, and 3 months after randomisation. results: the investigators will evaluate platelet turnover and aggregation, coagulation, fibrinolysis, and inflammatory markers before and after short- and long-term exercise, and the two randomised groups will be compared. perspectives: the present study will increase our knowledge of the beneficial mechanisms underlying the effect of exercise in cad patients, potentially paving the way for improved exercise recommendations.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * angiographically verified coronary artery disease with stenosis of at least 50% or previous percutaneous coronary intervention (pci)/coronary artery bypass graft (cabg) surgery. * diagnosis or revascularisation have been made at least 12 months prior to inclusion. exclusion criteria: * inability to perform strenuous exercise * anticoagulant treatment * heart failure (ejection fraction \ 2) * implanted implantable cardioverter defibrillator (icd) or cardiac resynchronization therapy (crt) * serious arrhythmia requiring hospitalisation within the last 6 months * severe valvular heart disease * chronic obstructive pulmonary disease gold iv

Keywords: cardiovascular diseases exercise hemostasis inflammation