Kornimate/medical-research-clean huggingface dataset:
optimization of time parameters of priming itbs for poststroke motor rehabilitation

Conditions: Stroke; Stroke Rehabilitation

Summary: the goal of this clinical trial is to identify the effect of different time intervals between continuous theta burst stimulation (ctbs) and intermittent theta burst stimulation(itbs), on top of a standard robot-assisted training (rat) for sensorimotor rehabilitation in patients with chronic stroke. using electroencephalography (eeg) to explore potential sensorimotor neuroplasticity underying stroke.

delivering intermittent theta burst stimulation (itbs) primed with continuous theta burst stimulation (ctbs) to the primary motor cortex (m1) may enhance the facilitatory effect of itbs on the stimulated m1 through metaplasticity. previous studies have verified the effectiveness of priming itbs on improving motor rehabilitation in patients with stroke. however, the optimal time interval between ctbs and itbs remains unknown. the aim of this clinical trial is to identify the effect of different time intervals between ctbs and itbs, followed with a standard robot-assisted training (rat) for sensorimotor rehabilitation in patients with chronic stroke. using electroencephalography (eeg) to explore potential sensorimotor neuroplasticity. a three-arm randomized controlled trial (rct) will be performed with an estimated total of 30 patients with chronic stroke. all participants will be randomly allocated to receive 10-session intervention of different tbs protocols (i.e., ctbs-3min interval-itbs, ctbs-10min interval-itbs and ctbs-20min interval-itbs), delivered for 2-4 sessions per week, lasting for 3-4 weeks. all participants will receive a 20-minute standard rat after each stimulation session. primary outcome will be fugl-meyer assessment-upper extremity scores (fma-ue). secondary outcomes will be action research arm test (arat), kinematic outcomes generated during rat as well as eeg.

Eligibility criteria:
inclusion criteria: 1. diagnosis of hemorrhagic or ischemic stroke using computed tomography (ct) or magnetic resonance imaging (mri). 2. the first-ever stroke with unilateral hemiplegia. 3. 18-75 years old. 4. chronic stroke ( ≥ 6 months). 5. residual hemiparetic upper limb functional level 2-6 in the functional test for the hemiplegic upper extremity (fthue-hk). 6. can understand and read chinese. 7. signed informed consent. exclusion criteria: 1. diagnosis of any clinically significant or unstable medical disorder. 2. any contraindications to tms based on the tms safety guidelines (rossi, hallett, rossini, \&amp; pascual-leone, 2011). 3. inability to follow treatment instructions due to severe cognitive (using the hong kong version of the montreal cognitive assessment (moca-hk) \&lt; 22/30) and communication deficiency. 4. extreme spasticity over the hemiparetic upper limb (modified ashworth score\&gt;2) or severe pain that hindered movement. 5. a history of neurological or psychiatric disease excluding stroke, or current use of psychoactive medication (sedatives, antipsychotics, antidepressants, etc.).

Keywords: stroke tms tbs eeg
comparison of proprioception for hto (high tibial osteotomy) and uka (unicompartmantal knee arthroplasty)

Conditions: Knee Osteoarthritis

Summary: osteoarthritis of the knee (koa), a common degenerative joint disease, affects a significant part of the world's population. although it can hold all the compartments in the knee joint, isolated medial compartment involvement has been reported in about 85% of individuals diagnosed with koa. in the management of degenerative medial gonarthrosis; symptomatic relief and provide orthopaedic surgeons with the aim to slow down the progression of total knee arthroplasty (tka) unikompartmental knee arthroplasty (uka) and high tibial osteotomy (hto) is used. in recent years, hto and uka have been preferred more frequently among these surgical methods due to a number of advantages they provide for patients. as a result of the orthopedic surgeries performed, interventions are made on bone and joint structures and problems may occur in the proprioceptive inputs provided by the body. in uka, a new joint structure is created by changing the bone structure and removing the tibial plateau, while in hto, the existing bone structure is preserved and a positional change is created. thus, while it is expected that the proprioceptive response to be different between the two surgeries, no studies have been found in the literature on this issue. accordingly, the purpose of this study is to compare the effects of hto and uka surgeries applied to individuals diagnosed with medial gonarthrosis on the proprioception of patients and to examine the effects of hto and uka surgeries on patients diagnosed with medial gonarthrosis. h0: there is no difference between the surgical methods applied when the proprioception of patients with hto and uka surgeries planned for individuals with medial gonarthrosis is considered. h1: there is a difference between the surgical methods applied when the proprioception of patients with hto and uka surgeries planned for individuals with medial gonarthrosis are considered.

volunteer participants who have been diagnosed with medial gonarthrosis and have varus deformity and have undergone surgery will be included. the surgical groups will be divided into two categories: hto and uka. evaluations of the participants in terms of proprioception will be made. a voluntary consent form will be obtained from the participants.

Eligibility criteria:
inclusion criteria: * undergoing surgery at the age of 50-65 * performing unilateral uka or hto surgery * moderate medial knee arthrosis on pre-op x-ray * presence of mild varus deformity in the pre-op period * should be bmi\<30 exclusion criteria: * regular exercise at least 3 days a week, 150 minutes, moderate intensity * having undergone revision surgery * the presence of any other orthopedic problems/problems and surgery * concomitant of a common rheumatological disease * presence of neurological problems/problems * having visual and auditory problems at a level that prevents communication

Keywords: gonarthrosis high tibial osteotomy unicompartmantal knee arthrodesis proprioception
large head x3 study

Conditions: Degenerative Joint Disease

Summary: the purpose of this study is to explore the benefit of x3 polyethlene inserts with larger diameter heads used in the japanese population. range of motion (rom) and lift-off distance for both 28mm, 32mm and 36mm in patients will be examined intraoperatively by using the stryker computerized tomography (ct) based navigation system. another aspect of this study is to observe wear resistance performance of x3 over historical liner existing highly crosslinked polyethylene.


Eligibility criteria:
inclusion criteria: 1. patient who is a candidate for primary total hip arthroplasty (tha) with cementless acetabular and femoral components. 2. patient who has diagnosis of degenerative joint disease and no bacterial infectious disease. 3. patient whose age is 20 or over. 4. patient who signed an institutional review board (irb)-approved, study specific informed patient consent form. 5. patient who is willing and able to comply with postoperative scheduled evaluations. exclusion criteria: 1. patient who has a bacterial infectious disease or has a high risk of a bacterial infection. 2. patient who requires revision surgery of a previously implanted total hip arthroplasty. 3. patient who is morbidly obese, defined as having a body mass index (bmi) \> 45. 4. patient who is or may be pregnant female. 5. patient who has a neuromuscular or neurosensory deficiency, which limits ability to evaluate the safety and efficacy of the device. 6. patient with diagnosed systemic disease (i.e. paget's disease, renal osteodystrophy). 7. patient who is immunologically suppressed or receiving chronic steroids. 8. patient who is judged ineligible with specific reason by primary doctor.
a study to compare the efficacy and safety of oral azacitidine plus best supportive care (bsc) versus placebo plus bsc in participants with international prognostic scoring system revised (ipss-r) low- or intermediate-risk myelodysplastic syndrome (mds)

Conditions: Myelodysplastic Syndromes

Summary: the purpose of this study is to evaluate the safety and efficacy of oral azacitidine in participants with low to intermediate international prognostic scoring system revised (ipss-r) myelodysplastic syndrome (mds).


Eligibility criteria:
inclusion criteria: • participant has a documented diagnosis of mds according to who 2016 classification that meets international prognostic scoring system revised (ipss-r) classification of low- or intermediate-risk disease (ipss-r score between 1.5 and 4.5). mds diagnosis, who classification, and ipss-r risk classification will be prospectively determined by independent central pathology and cytogenetics review, and applicable central laboratory results. • participant must have an eastern cooperative oncology group (ecog) performance status of 0, 1, or 2. exclusion criteria: * participants with prior malignancies must have an expected median life expectancy of at least 12 months at the time of inclusion and no active treatment of any sort for at least 24 weeks prior to randomization (including but not limited to immunotherapy or targeted therapy) * hypoplastic myelodysplastic syndrome (mds) with a marrow cellularity of ≤ 10% * participants diagnosed with mds with excess blasts-2 (mds-eb2) * prior treatment with azacitidine (any formulation), decitabine, or other hypomethylating agent other protocol-defined inclusion/exclusion criteria apply

Keywords: anemia thrombocytopenia
dupilumab phase 4 study

Conditions: Atopic Dermatitis

Summary: the investigators will monitor for the incidence of adverse-events in a prospective, longitudinal, non-interventional and observational real-world sub-study of adults patients with moderate-to-severe ad who are receiving dupilumab as standard-of-care therapy.

the investigators will conduct a prospective, longitudinal, non-interventional and observational sub-study of patients receiving dupilumab as normal standard-of-care treatment to assess the efficacy (specific aim #1) and safety (specific aim #2) of dupilumab for the treatment of moderate-to-severe ad, as well as the prevention and/or mitigation of comorbid health conditions (specific aim #3). this study will address the hypotheses that dupilumab will lead to improved long-term control and decreased severity of ad, and that long-term monitoring will shed light on the incidence of adverse drug events.

Eligibility criteria:
inclusion criteria: * individuals aged 18 and over who have been diagnosed with atopic dermatitis and are using dupilumab therapy as part of standard of care. * parents of adolescents ages 12 to 17 who have been diagnosed with atopic dermatitis and are receiving dupilumab off-label for the management of ad. exclusion criteria: * patients not on dupilumab * those who do not comply with the study requirements * those who do not provide informed consent

Keywords: atopic dermatitis, dupilumab
work productivity and social activities in patients with ankylosing spondylitis

Conditions: Ankylosing Spondylitis; Work Productivity

Summary: the aim of this study is to evaluate the relationship between decrease in work productivity and social activities in patients with ankylosing spondylitis (as) with disease activity, depression and quality of life together with demographic data.

for this study, which is planned as a cross-sectional clinical study, 100 patients who were diagnosed with as between the ages of 18-65 and who applied to the istanbul physical therapy rehabilitation suam physical medicine and rehabilitation outpatient clinic between april 15, 2019, and april 15, 2020, and 100 healthy volunteers compatible with age. was included. demographic data of the participants were recorded. work productivity and activity reduction questionnaire: general health (wpai: gh), social role participation questionnaire short form (srpq), short form-36 (sf-36), hospital anxiety, and depression scale (hads), will be evaluated. besides, if the patient group exists, laboratory results (crp, erythrocyte sedimentation rate, hla-b27), and bath ankylosing spondylitis functional index (basfi), bath ankylosing spondylitis disease activity index (basdai), bath ankylosing spondylitis metrology index (basmi), visual analog scale (vas) resting, night and activity values were recorded.

Eligibility criteria:
inclusion criteria: * patients with as diagnosis between the ages of 18-65 * healthy volunteer individuals between the ages of 18-65 without known musculoskeletal disease exclusion criteria: * those with serious systemic diseases that may interfere with working (respiratory system, cardiovascular system, renal and metabolic diseases) * those with orthopedic and psychiatric diseases * those with inflammatory diseases other than known as * pregnant * people with disability due to the history of trauma * those with injury after the operation * those with diseases that cause neurological sequelae

Keywords: spondylitis ankylosing quality of life employment
comparison of erector spinae plane block and serratus posterior superior intercostal plane block

Conditions: Erector Spinae Plane Block; Serratus Posterior Superior Intercostal Plane Block; Acute Pain; Postoperative Pain; Breast Neoplasms

Summary: breast cancer is the most common malignancy in women. modified radical mastectomy, a surgical procedure in the treatment of breast cancer, is one of the standard treatments. postoperative pain can seriously reduce the quality of life in patients, and inadequately treated acute pain can trigger chronic pain syndrome. therefore, thoracic paravertebral block and thoracic epidural block are effective in postoperative analgesia. however, the use of these blocks is limited due to complications. in recent years, less invasive blocks, such as pectoral nerve block (pecs i-ii), serratus anterior plane block (sapb), erector spinae plane block (espb), and serratus posterior superior intercostal plane block (spsi̇pb) have been applied. in this study, it was aimed to compare the analgesic effectiveness of espb and spsi̇pb applications in patients undergoing breast surgery.

postoperative pain will be assessed during resting and coughing with a visual analog scale (0-10 cm) and nausea and vomiting with a postoperative nausea vomiting score at the postoperative 1, 4, 8, 12, and 24 hours. the amount of tramadol consumed in the postoperative period will be recorded. patient satisfaction will be assessed with the likert scale at postoperative 24 hours.

Eligibility criteria:
inclusion criteria: * those aged 18-65 * those with asa scores i-ii-iii * those with a body mass index (bmi) between 18-35 * patients who will undergo breast surgery exclusion criteria: * those under the age of 18 and over the age of 65 * those with asa score iv and above * those with a history of allergy to the drugs to be blocked * those with a history of bleeding diathesis * patients with infection in the area to be blocked * those with a bmi below 18 and above 35 * patients who underwent surgery under emergency conditions
tap block or wound infiltration for laparoscopic pediatric appendectomy: a pilot study

Conditions: Appendectomy; Laparoscopy; Anesthesia, Conduction; Child, Preschool

Summary: effectiveness of the tap block compared to wound infiltration in controlling pain after laparoscopic appendectomy in children

laparoscopic appendectomy is one of the main emergency surgical procedures performed in children. the available local anesthesia techniques include wound infiltration or "wall" blocks such as the tap (transversus abdominis plane) block. the greater evidence on the adult population suggests that both techniques are valid for pain control in the immediate postoperative period, although wall blocks can guarantee a more prolonged analgesic effect over time. the evidence on the pediatric population, on the other hand, is less strong and sometimes conflicting: therefore, the objective of our study is to verify the efficacy of tap block compared to wound infiltration in the control of postoperative pain after appendectomy in pediatric patients.

Eligibility criteria:
inclusion criteria: * patients aged between 3 and 16 years, candidates for laparoscopic appendectomy for suspected acute appendicitis. * asa physical status class i and ii * informed consent signed by parents / legal guardians exclusion criteria: * severe obesity (bmi\> 95th percentile for age and weight) * perforated appendicitis * paralytic ileum * non-stabilized neuropathies * allergy to local anesthetics or analgesics used in the study protocol. * patients on chronic opiate treatment * need for perioperative hospitalization in intensive care with sedation and / or mechanical ventilation

Keywords: tap block wound infiltration laparoscopic appendectomy levobupivacaine pediatric surgery pediatric anesthesia
the effect of whole-body vibration treatment before total knee arthroplasty

Conditions: Whole-body Vibration; Arthropathy of Knee; Swelling/ Edema

Summary: the study's objective is to investigate the effects of whole-body vibration therapy administered before surgery on various factors related to patients who undergo total knee arthroplasty. these factors include pain, swelling, skin temperature, normal joint movement, knee joint position sense, knee extensor muscle strength, functional status, and patient satisfaction.

the study will include participants aged 50-80 who are planning to undergo total knee arthroplasty. according to the sample size analysis, a total of 40 people will be included in this study. the enrolled participants will be randomly assigned to one of two parallel groups: the whole-body vibration group or the sham whole-body vibration group. both groups will receive standard patient education and exercise training.the experimental group will receive whole-body vibration along with exercise on the whole-body vibration device, while the control group (sham group) will receive sham vibration on the same device. all participants will receive treatment for a total of 5 days, one session per day.

Eligibility criteria:
inclusion criteria: * patients with advanced idiopathic knee oa and scheduled for unilateral total knee arthroplasty will be considered candidates for the present study and will be asked to participate exclusion criteria: * if they had undergone another hip or knee joint replacement in the previous year * if they had any medical condition in which exercise was contraindicated * if they had any disease that affected functional performance

Keywords: whole-body vibration total knee arthroplasty swelling edema
effect of whole-body vibration on postural stability, muscle flexibility and lower limb power in young basketball players with generalized joint hypermobility

Conditions: Generalized Joint Hypermobility

Summary: the goal of this clinical trial is to assess the effect of whole body vibration (wbv) on postural stability, flexibility of the lumbar-pelvic-hip complex and lower leg muscles, and jumping ability in basketball players aged 9-15 years. the main questions it aims to answer are: does wbv affect the level of postural stability in basketball players aged 9-15 years? does wbv affect the level of postural stability in basketball players aged 9-15 years? does wbv affect the flexibility of the iliopsoas, rectus femoris, posterior group of hamstrings, soleus and gastrocnemius in basketball players aged 9-15 years? does wbv affect the jump height, relative peak power, contraction time in basketball players aged 9-15 years? participants will take part in 6 vibration sessions at 20hz over 6 weeks. vibration will be performed on the galileo med35 platform (3x3 min).


Eligibility criteria:
inclusion criteria: * men aged 9-15 * playing basketball in a sports club at least 2 training sessions a week exclusion criteria: * thrombosis (acute narrowing of blood vessels), * inflammation of the musculoskeletal system, * arthropathy, * hernias, * discopathies, * tendonitis, * fresh fractures, * scars, * surgeries, * kidney stones, * rheumatoid arthritis, * implants in the body, * epilepsy, * current injuries to the musculoskeletal system, * occurrence of chronic pain complaints of the musculoskeletal system.
early warning and optimization strategy in carotid endarterectomy

Conditions: Carotid Stenosis; Carotid Artery Diseases; Stroke; Vascular Diseases

Summary: carotid endarterectomy has been proven effective in prevention of cerebral vascular events in patients with severe carotid artery stenosis (symptomatic,\>50%;asymptomatic,60%). but during the surgery, when the carotid artery is clipping, the patient will have the chance to have hypoperfusion or stroke. our study is designed to determine how to use tcd to reduce the risk of death and nonfatal stroke in patients .

aha guidelines recommend carotid endarterectomy (cea) for severe carotid stenosis. but during cea, there is little chance that the patient suffer from severe hypoperfusion or stroke. so we use tcd to monitor the blood flow of brain in the surgery and keep the blood pressure stable. the sudy is designed to find out whether the index which we found in previous work is more sensitive to show the blood flow of middle cerebral artery.

Eligibility criteria:
inclusion criteria: * carotid artery stenosis detectable by duplex ultrasound, and no previous procedure done on it, which might well need procedural treatment now with cea or cas. * already started any appropriate medical treatment (eg, statin, aspirin etc), and already recovered from any necessary coronary procedures (eg, cabg) * patient seems fit and willing for follow-up in person (at 1 month) and by annual letter (for at least 5 years) * some type of angiography (eg, mra or cta) has already been done that has shown that cea . exclusion criteria: * small likelihood of worthwhile benefit (eg, very low risk of stroke because stenosis is very minor, or major co-morbidity or life-threatening disease, such as advanced cancer)

Keywords: internal carotid artery stenosis carotid endarterectomy stroke cerebrovascular atherosclerosis
post marketing surveillance study to observe safety and efficacy of ibrance®

Conditions: Breast Neoplasm

Summary: this non-interventional study is designated as a post marketing surveillance study and is a commitment to ministry of food and drug safety (mfds). before the approval of ibrance® in korea, as a part of risk management plan (rmp), which is required by mfds, safety and efficacy information of new medication will be provided at minimum 1,000 participants administered in the setting of routine practice during the initial 9 years after the approval.


Eligibility criteria:
inclusion criteria * women of ≥18 years of age with proven diagnosis of advanced/metastatic breast cancer (locoregionally recurrent or metastatic disease). * estrogen receptor+ (er+) and/or progesterone receptor+ (pgr+) tumor based on local laboratory results (test as per local practice). * human epidermal growth factor receptor 2 -(her2-) breast cancer based on local laboratory results (test as per local practice or local guidelines) * patients must be appropriate candidates for hormone therapy. * evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study. * during the post marketing surveillance (pms) period, patients who initially administer ibrance® exclusion criteria * known hypersensitivity to letrozole or its excipients or to any cyclin-dependent kinase 4/6 (cdk4/6) inhibitor excipients. * pregnant women

Keywords: metastatic breast cancer safety ibrance