Kornimate/medical-research-clean huggingface dataset:
efficacy of two oral hygiene regimens in the reduction of dentin hypersensitivity after periodontal treatment

Conditions: Dentin Sensitivity; Periodontal Diseases

Summary: this study aim is to determine the efficacy of two oral hygiene regimens in the reduction of dentin hypersensitivity on subjects undergoing non-surgical periodontal treatment, over a period of 8 weeks.

this study aim was to determine the efficacy of two oral hygiene regimens in the reduction of dentin hypersensitivity on subjects undergoing non-surgical periodontal treatment, over a period of 8 weeks. the study was conducted in piracicaba dental school, piracicaba, são paulo, brazil, using a double-blind/two treatment design. sixty subjects (30 per group) that meet the inclusion and exclusion criteria were assigned to the groups: test group (non-surgical periodontal treatment + in-office application of colgate sensitive pro-relief - cspr + tooth brushing with at home cspr toothpaste) and control group (non-surgical periodontal treatment + in-office application of a fluoride-free prophy paste + tooth brushing with a colgate cavity protection toothpaste). air blast sensitivity assessments were used to compare the efficacy of the two approaches using both the schiff scale. the sensitivity parameters were measured at baseline, 1, 4 and 8 weeks.

Eligibility criteria:
inclusion criteria: 1. males and females, between 30-75 years of age; 2. availability for the duration of the study; 3. individuals diagnosed with moderate chronic periodontal disease (4-5 mm loss of clinical attachment, according to aap), and indication for non-surgical periodontal therapy; 4. diagnosis, by air blast, of at least two (2) hypersensitive teeth with a score of 2 or 3 on the schiff cold air sensitivity scale; 5. subjects in good general health and no allergies to products that are being tested. exclusion criteria: 1. oral pathology, chronic disease, or a history of allergy to testing products; 2. qualifying sensitive teeth with extensive/defective restorations, pulpitis, caries, cracked enamel, or these teeth used as abutments for removable partial dentures; 3. subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; 4. subject regularly using desensitizing toothpaste; 5. current smokers; 6. subject pregnant or breast feeding; 7. allergies to oral care products, personal care consumer products, or their ingredients.

Keywords: dentin hypersensitivity periodontal disease arginine
the effects of different ventilator strategies on inflammation and injury in normal lungs

Conditions: Acute Respiratory Distress Syndrome

Summary: this research is being done to determine if there is a way the investigators can improve the techniques that they use to assist patients with their breathing during surgery. the majority of surgeries require patients to concurrently undergo general anesthesia. this usually includes a breathing tube and a machine that breathes for the patient during the duration of the surgery. the doctors would like to investigate the effects of this type of anesthesia to healthy adult patients and whether they can improve the way they give general anesthesia to patients. the investigators plan to ask approximately 200 patients to participate. if the patients decide to participate in the study,some additions will be made to the standard anesthetic care they receive. the patients will additionally be monitored for adequate oxygenation in their blood as well as level of inflammation in their blood and lungs. the patients' breathing tube will be bathed with warm normal saline and suctioned twice during the operation. when these procedures are done the patients will be asleep and not be aware of what is happening.

the ability to provide mechanical ventilation that will not injure and may protect normal lungs during major surgical procedures of long duration may improve postoperative outcomes and decrease morbidity and mortality. the aim of the current study was to identify ventilator strategies that are less damaging to normal lungs. the investigators plan to compare three ventilation strategies commonly utilized in the operating room in normal lungs. one group will be ventilated with high tidal volume (15 ml/kg pbw) and low peep (3 cm h2o), another group ventilated with low tidal volume (6 ml/kg pbw) and low peep (3 cm h2o) and the final group ventilated with low tidal volume (6 ml/kg pbw) and high peep (10 cm h2o). this study will show the effects of these commonly used methods of ventilation on pulmonary mechanics, systemic and pulmonary inflammatory markers and outcomes in patients with normal lungs undergoing surgery of long duration.

Eligibility criteria:
inclusion criteria: * elective surgery under general anesthesia expected to take 4 hours or more positioned supine for surgery exclusion criteria: * subjects who have hiv or who have had radiation or chemotherapy for cancer * subjects undergoing surgery on chest or lings * subjects who have obstructive sleep apnea (osa), asthma, tuberculosis, chronic obstructive pulmonary disease

Keywords: intraoperative protective ventilation strategies
safety and efficacy trial of a targeted psma fluorescent contrast agent (dgpr1008) for intraoperative imaging of prostate cancer

Conditions: Prostate Cancer Patients Undergoing Radical Prostatectomy

Summary: a single-arm, open-label, multi-center study to evaluate safety, tolerability, pharmacokinetics, and the effectiveness of near-infrared fluorescence imaging during surgery.

we plan to enroll 24 prostate cancer patients and divide them into 2 dosage groups. intravenous administration will be conducted 24 hours before surgery. blood samples will be collected for relevant tests, and fluorescence imaging will be performed during the operation. after surgery, the intraoperative imaging results will be compared with pathological findings to draw relevant conclusions.

Eligibility criteria:
inclusion criteria: * subjects must provide informed consent prior to enrollment, fully understand the trial details, adverse events, and communicate effectively with investigators. written informed consent must be voluntarily signed. adult male subjects aged ≥18 years. subjects with pathologically confirmed prostate cancer (gleason score ≥7) via pre - operative prostate biopsy, scheduled for radical prostatectomy. no significant liver or kidney impairment: liver - total bilirubin ≤2×uln (except gilbert syndrome), alt/ast ≤3×uln; kidney - creatinine clearance rate ≥50 ml/min/1.73m² (simplified mdrd). no surgical contraindications; suitable for laparoscopic radical prostatectomy as determined by the investigator. subject and partner/spouse agree to avoid conception and sperm donation from screening until 3 months post - trial, and use effective contraception. exclusion criteria: * subjects will be excluded if any of the following apply: allergic constitution (history of allergy to ≥2 drugs), prone to allergic reactions, or allergic to the investigational drug (including components). clinically significant abnormal screening results affecting the study, or serious concomitant diseases (except stable cases approved by the investigator). participation in other clinical trials and received investigational products within 1 month before study drug administration. other conditions deemed unsuitable for enrollment by the investigator.

Keywords: dgpr1008
german diabetes-diet-intervention and energy restriction-trial (ddiet)

Conditions: Type 2 Diabetes

Summary: diet intervention according to the german diabetes risk score in newly diagnosed type 2 diabetes. this study aims to explore the effect of diet lacking red meat, but containing increased fibers and coffee (verum) versus standard recommendation (control) in a multicenter setting.

this study is a randomised, multicenter controlled trial our aim is to test the effects of an 8-week diet lacking red meat, containing increased fibers and coffee (verum) versus standard recommendation (control)in a multicenter setting. we are expecting that the verum diet will improve insulin sensitivity and insulin secretion due to reductions in visceral and hepatic fat along with improved adipocyte cytokine secretion profiles

Eligibility criteria:
inclusion criteria: * type 2 diabetic patients * disease duration for five years or less, * age of 69 years or less, * body mass index of 30 kg/m2 or more, * hemoglobin a1c of 5,5 % to 9% * patient should be on standard diet or metformin +/- acarbose monotherapy * patient should be without exclusion criteria for coffee consumption exclusion criteria: * disease duration more than five years, * age of \> 69 years, * body mass index of \< 30 kg/m2, * hemoglobin a1c \ 9% * if patient becomes insulin therapy * if patient has exclusion criteria for coffee consumption * if patient is non-compliant with study protocol * if patient is pregnant * if patient has acute infection * if patient has anaemia * if patient has malignancies * if patient has autoimmune or immune compromising diseases including hiv/aids * if patient has psychiatric diseases or addiction

Keywords: insulin sensitivity type 2 diabetes diet intervention
perioperative metabolic and hormonal aspects in major emergency surgery

Conditions: Surgery--Complications; Acute Illness; Gastrointestinal Disease; Stress

Summary: emergency laparotomies, which most often is performed due to high risk disease (bowel obstruction, ischemia, perforation, etc.), make up 11 % of surgical procedures in emergency surgical departments, however, give rise to 80 % of all postoperative complications. the 30-day mortality rates in relation to these emergent procedures have been reported between 14-30 %, with even higher numbers for frail and older patients. the specific reasons for these outcomes are not yet known, however, a combination of preexisting comorbidities, acute illness, sepsis, and the surgical stress response that arise during- and after the surgical procedure due to the activation of the immunological and humoral system, is most likely to blame. the complex endocrinological response and consequences of this response to emergency surgery are sparsely reported in the literature. the aim of this phase project is to evaluate and describe the temporal endocrine, endothelial and immunological changes after major emergency abdominal surgery, and to associate these changes with clinical postoperative outcomes.


Eligibility criteria:
inclusion criteria: * surgery within 72 hours of an acute admission to the department of surgery or an acute reoperation. * major gastrointestinal surgery on the gastrointestinal tract (see intervention definition) exclusion criteria: * not capable of giving informed consent after oral and written information * previously included in the trial * elective laparoscopy * diagnostic laparotomy/laparoscopy where no subsequent procedure is performed (nb, if no procedure is performed because of inoperable pathology, then include) * appendectomy +/- drainage or cholecystectomy +/- drainage of localized collection unless the procedure is incidental to a non-elective procedure on the gi tract * non-elective hernia repair without bowel resection. * minor abdominal wound dehiscence unless this causes bowel complications requiring resection * ruptured ectopic pregnancy, or pelvic abscesses due to pelvic inflammatory disease * laparotomy/laparoscopy for pathology caused by blunt or penetrating trauma, esophageal pathology, pathology of the spleen, renal tract, kidneys, liver, gall bladder and biliary tree, pancreas or urinary tract

Keywords: inflammation insulin-glucose homeostasis hypothalamic-pituitary-adrenal axis endothelial function and damage thyroid hormones
comparison of femoral nerve catheter and adductor canal block with steroid adjuvant in total knee replacement (tkr)

Conditions: Osteoarthritis

Summary: we hypothesize continuous adductor canal block with steroid adjuvant would offer no inferior analgesics and rehabilitation ability than continuous femoral nerve block for postoperative patients receiving total knee arthroplasty.

a total of 80 patients who will undergo total knee arthroplasty will be randomized into two groups: treatment groups treatment details femoral group (40 patients) continuous femoral nerve block (bolus: 0.5% ropivacaine 10-15 ml ; infusion of 0.15 % ropivacaine 4-6ml/h) adductor group (40 patients) adductor canal block with steroid adjuvant (bolus: 0.5% ropivacaine 10-15ml; dexamethasone 4mg) (total 80 patients will be recruited) * all patients will receive single shot tibial nerve block with local anaesthetics (0.5% ropivacaine 5-8ml) before surgery for analgesia of posterior knee. * all patients will receive the same preemptive and postoperative multimodal medications for perioperative analgesia. * all groups will receive standardized method of spinal anaesthesia and standardized method of intraoperative sedation for the surgery. * intravenous patient controlled analgesia (pca) with morphine will be given for 48h to patient as rescue analgesia.

Eligibility criteria:
inclusion criteria: * diagnosis of primary osteoarthritis * scheduled for elective total knee arthroplasty * signed written informed consent * planned use of spinal anaesthesia * cognitive sound to use assessment tools exclusion criteria: * patients refusing to give consents * scheduled for revision total knee replacement * patient outside range of 30 to 80 yrs old * non-chinese population * cognitive impairment/ inability to use the outcome assessment tools * contraindications to regional anesthesia * severe cardiovascular disease (unstable angina, second or third degree heart block) * pre-existing neurologic disease including psychiatric disorder * drug abuser * pre-operative history of neurological abnormality in the ipsilateral leg e.g. history of stroke, neurogenic pain or previous nerve injury. * allergy or contraindication to drugs used in this study: morphine, non-steroidal anti-inflammatory drugs (nsaid) such as ketorolac , diclofenac, dihydrocodeine, local anaesthetics (lignocaine, ropivacaine, bupivacaine), epinephrine * moderate or severe renal impairment (serum creatinine \> 160 micromol/l)

Keywords: femoral nerve block adductor canal block steroid total knee replacement
neo-masct immunotherapy for advanced nsclc.

Conditions: NSCLC Stage IV

Summary: neoantigen （neo）is a new targets for immune cells，that the dc neoantigen immunotherapy was more effective in triggering specific t-cell responses. neo-masct using the dc vaccine and neoantigen t cells .dendritic cells(dc) was induced from autologous peripheral blood，and be loaded with antigens and re-infused. in vitro, antigen-pulsed dc can stimulate autologous t-cell proliferation and induction of autologous specific cytotoxic t-cells(ctl)，similarly re-infused. the study is aimed to evaluate the safety of neo-masct in patients with advanced nsclc.

this study is divided into two stages. the first stage is the safety study in small samples, and the second stage is the sample size expansion phase. 20 failed standard treatment patients with advanced or recurrent nsclc will be recruited .

Eligibility criteria:
inclusion criteria: 1. the age is 18 to 80 years old. 2. the failure standard treatment subjects with advanced or relapsed nsclc. 3. informed consent of the patient/legal representative was signed. 4. other anti-cancer treatments are at least one month apart from the study . 5. the eastern cancer cooperative group (ecog) was rated 0-2. 6. according to the the reaction of solid tumors v1.1 (recist1.1 standard), there must be at least one measurable lesion . 7. the baseline blood and biochemical targets met the following criteria: the hemoglobin ≧ 85g/l ;white blood cells ≧ 3.0 x10 \^ 9 / l;platelet ≧ 50 x10 \^ 9 / l;alanine aminotransferase (alt), serum aspartate transaminase(ast) ≦ 2.5 times normal value limit; for patients with live metastases, alt and ast are five times the normal limit; the alkaline phosphatase(alp) ≦ 2.5 times the normal value; serum bilirubin less than 1.5 times the normal value limit; exclusion criteria: 1. participate in the planning or implementation of the research . 2. in addition to other clinical studies, unless it is an observational clinical study . 3. being pregnant or planning a pregnancy. 4. refuse to provide a blood specimen . 5. allergic to sodium hydroquinone . 6. there is a history of organ transplantation 7. brain transfer of the active period 8. immunosuppressant drugs are currently in use or within 14 days prior to treatment. 9. the following exceptions are:nasal, inhaled, topical use of steroid, or topical steroids (such as interjoint injection) . 10. use a corticosteroid, no more than 10mg/day of prednisolone or its equivalent . 11. the use of steroids as a preventative treatment for hypersensitivity (such as ct scans) .
bowel preparation and pelvic organ prolapse surgery

Conditions: Pelvic Organ Prolapse

Summary: the purpose of this study is to find out if performing a bowel preparation prior to pelvic organ prolapse surgery has any effect on the return of bowel function after surgery.


Eligibility criteria:
inclusion criteria: * are between the ages of 21-90 years. * have a posterior vaginal wall prolapse. * are undergoing vaginal prolapse reconstructive surgery including posterior repair with suspension of the vaginal apex (top) to the ligaments in your pelvis, repair of the cul de sac or "enterocele", with or without anti-incontinence surgery. * are receiving general anesthesia. exclusion criteria: * patient undergoing concomitant anal sphincteroplasty, rectovaginal fistula repair, rectopexy, or rectal resection/reanastomosis. * patient undergoing any mesh augmentation. * patient with any neurological condition involving bowel function. * patient on regular narcotic medication preoperatively. * patient does not want to be in the group she was randomized to. * patient currently pregnant or planning to become pregnant, or breastfeeding. * patient with ascites. * patient with known or suspected gastrointestinal obstruction or perforation. * patient with history of hyperparathyroidism. * patient with dehydration. * patient with active inflammatory bowel disease. * patients with congestive heart failure. * patients with dialysis dependent renal disease.

Keywords: pelvic organ prolapse bowel preparation
effect of functional power training on calf muscle length and strength in children with spastic paresis

Conditions: Cerebral Palsy, Spastic

Summary: spastic paresis (sp) is a common motor condition in children and is often caused by cerebral palsy. skeletal muscles develop differently in children with sp due to brain damage in early development; muscle strength and muscle length are reduced compared to typically developing (td) children. especially, the calf muscles are affected, which particularly affects their ability to walk and to run, hindering participation in society. there are several treatments aimed to increase the range of motion of the joint by lengthening the muscle, for example botulinum toxin injections. however, these treatments can have a weakening effect on the muscle due to deconditioning from immobilization and due to paralysis. in rehabilitation centers in the netherlands functional power training (megapower) is offered to children with sp who want to walk and run better. it has been shown that this training improves calf muscle strength and performance during functional walking tests. however, the effect of megapower training on muscle morphology (i.a. muscle volume and length) is still unknown. therefore, the aim of this study is to assess the effect of megapower training on the muscle morphology of the medial gastrocnemius in children with sp using 3d ultrasonography. it is expected that megapower training results in an increase of muscle volume as well as elongation of the muscle belly. muscle volume could increase due to hypertrophy of the muscle fibers induced by the training, which could elongate the muscle belly length due to the pennate structure of the medial gastrocnemius. a double-baseline design will be applied for this study with three different measurement times (t0-t1-t2) to compare the training period (12 weeks) with a period (12 weeks) of usual care.


Eligibility criteria:
inclusion criteria: * gross motor function classification system i-iii * children should be able to lie on their stomach for min. one minute * children should be able to follow instructions. exclusion criteria: * received (one of) the following interventions within six months: * casting * botulinum toxin type-a injections * orthopedic surgery.

Keywords: medial gastrocnemius morphology 3d ultrasonography functional power training
influence of oesophageal contractile reserve in high resolution manometry on post operative dysphagia after anti-reflux surgery

Conditions: Dysphagia

Summary: the main objective of this study is to evaluate, in a prospective cohort, the link between preoperative contractile reserve of oesophagus evaluated by high resolution manometry (hrm) and the occurrence of post operative dysphagia after anti-reflux surgery.


Eligibility criteria:
inclusion criteria: * patient with an indication validated at a fundoplication directed by a visceral surgeon from vienne county * patient sent for the realization of a preoperative hrm, * patient giving consent to participate in the study. exclusion criteria: * patient unable to sign a consent or protected (minors, pregnant women, patient under guardianship), * history of oesophageal surgery or radiotherapy, * history of systemic pathology with oesophageal involvement, * contraindication to an oesophageal manometry : altered general status and vigilance , important swallowing disorders
effect of tranexamic acid on postoperative bleeding following sinus and nasal surgery

Conditions: Chronic Sinusitis; Nasal Obstruction; Turbinate; Hypertrophy Mucous Membrane; Deviated Nasal Septum - Congenital; Deviated Nasal Septum Acquired

Summary: the purpose of the research is to assess the effectiveness of a dose of intravenous tranexamic acid (txa) given intraoperatively to reduce postoperative bleeding after endoscopic sinus or nasal surgery (e.g. septoplasty, endoscopic sinus surgery, turbinate surgery). this medication has been shown to decrease blood loss during this type of surgery, but the implications for bleeding following surgery are unclear. any impact on postoperative bleeding will be assessed over the first 7 days following surgery leading up to the first scheduled postoperative clinic visit. patients will keep a standardized daily diary of their bleeding experience by indicating on a 0-10 visual analog scale (vas) their impression of their bleeding. the primary outcome is the patient-reported visual analog scale (vas) bleeding score on each day after surgery. the secondary outcomes include the the frequency with which the otolaryngology resident service is requested to evaluate patients in the recovery unit for postoperative bleeding concerns and the frequency of interventions such as application of hemostatic materials, packing, cautery, and/or return to the operating room.


Eligibility criteria:
inclusion criteria: * scheduled to undergo elective sinus or nasal surgery (e.g. septoplasty, inferior turbinate reduction, endoscopic sinus surgery) * age 18 or greater * english-speaking * able to provide consent exclusion criteria: * minors (age\<18) * pregnant or may become pregnant by time of surgery * prisoners * non-english speaking * foreign citizens * unable to provide consent * known pro-thrombotic coagulation disorders * active intranasal drug use (e.g. cocaine) * surgery is for a sinonasal tumor or other sinus pathology not described in inclusion criteria * enrollment is in conflict with existing study participation