Kornimate/medical-research-clean huggingface dataset:
effect of dexmedetomidine on pain due to propofol injection

Conditions: Pain; Intravenous Propofol Injection

Summary: propofol is commonly used iv anesthetic, it has been formulated in a concentration of 10 mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides). when used for anesthetic induction, propofol causes pain on injection in 28%-90% of patients. pain probably results from a direct irritant effect. several methods have been used to reduce this pain. lidocaine pretreatment has been commonly proposed to decrease propofol induced pain, but its failure rate is between 13-32%. dexmedetomidine is highly selective alfa-2 adrenoreceptor agonist. alpha-2 receptors are located on blood vessels where they inhibit norepinephrine release. investigators, therefore, speculated that dexmedetomidine could attenuate the pain due to injection of propofol. investigators conducted a study to determine the efficacy of dexmedetomidine in decreasing pain due to injection of propofol.

propofol solution is fat emulsion consisting of soyabean oil. when used for anesthetic induction, propofol causes pain or discomfort on injection. many factors appear to affect the incidence of pain, which includes site of injection, size of vein, speed of injection, buffering effect of blood, temperature and composition of propofol solution and concomitant use of drugs such as local anaesthetics and opiates. pain on injection of propofol can be immediate or delayed. immediate pain probably results from a direct irritant effect whereas delayed pain probably results from an indirect effect via the kinin cascade. delayed pain has latency of between 10 and 20 s. the pain produced is usually described as tingling, cold, or numbing, at its worst, a severe burning pain proximal to the site of injection. this sensation tends to occur within 10-20 s of injection and lasts only for the duration of injection. despite this discomfort, the incidence of phlebitis is less than 1%. several methods have been used to reduce this pain with limited success. lidocaine pretreatment is commonly used to decrease propofol induced pain, but its failure rate is between 13-32%. dexmedetomidine is an selective alfa-2 adrenoreceptor agonist with supraspinal, spinal, and peripheral actions. alpha-2 receptors are located on blood vessels where they inhibit norepinephrine release. investigators, therefore, speculated that dexmedetomidine could attenuate the pain due to injection of propofol.

Eligibility criteria:
inclusion criteria: * asa i \& ii * both gender * age 18-60 * elective surgery exclusion criteria: * patients taking sedatives or analgesics in the past 24 hours * history of allergic reactions to anesthetic drugs, * atrio-ventricular conduction defects * cardiovascular disease and * pregnant

Keywords: propofol pain dexmedetomidine
assessment of efficacy and safety of tocilizumab compared to deferoxamine, associated with standards treatments in covid-19 (+) patients hospitalized in intensive care in tunisia

Conditions: COVID19; Intensive Care Unit

Summary: assessment of efficacy and safety of tocilizumab compared to deferoxamine, associated with standards treatments in covid-19 (+) patients, hospitalized in intensive care in tunisia. multicentric, comparative, randomized study.

arm1 : * usual standard treatment\* * tocilizumab (loc) (8mg/ kg per day) (1 injection per infusion) a second injection may be considered if necessary, but no more than 800 mg per day. only on the 1st day (d0) * enoxaparin (4000 iu x 2) per day for the duration of hospitalization versus arm 2: * usual standard treatment\* * deferoxamine (desferal 500 mg, powder, and solvent for iv solution) by electric syringe 40 mg/kg/day 5day/7 without exceeding 5 g per day for 14 days * enoxaparin (4000 iu x 2) per day for the duration of hospitalization usual standard treatment\*: according to the standard practices of each center, apart from the active molecules of the 2 arms and their therapeutic class)

Eligibility criteria:
inclusion criteria: * patient confirmed covid19 positive * patient with acute respiratory deficiency * patient hospitalized in the intensive care unit * age \>18 years old * having given written consent for their participation in the study exclusion criteria: * taking tocilizumab or hydroxychloroquine deferoxamine within one month prior to inclusion (excluding participation in thinc or covid_2pro or covid+pa studies) * severe/severe liver failure * dialysis patients * renal insufficiency (clearance\< 30ml/min/1.73m2) * allergy to deferoxamine * pregnant or breastfeeding woman * hypersensitivity to the active substance or any of the excipients of tocilizumab * a decrease in blood platelets with previous use of enoxaparin or another heparin drug, * hemophilia and related diseases, * stomach or duodenal ulcer

Keywords: deferoxamine tocilizumab
effects of foam rolling, foam rolling with dynamic movement, and static stretching on plantar flexor range of motion and tissue properties in healthy participants

Conditions: Healthy Subjects (HS)

Summary: each voluntary participant will be invited and tested at the functional assessment laboratory. after reading and completing the informed consent document regarding our research and data processing, participants will be invited for four separate sessions at the laboratory. during the first session, essential personal information (name, surname, sex, age) will be recorded. immediately after measuring the participant's height using a stadiometer and weight using a scale, several tests will be conducted to assess pain thresholds and tissue density using specific dynamometers, joint mobility levels of the participants (passive muscle mobility test and a test using the accelerometer), and a bioimpedance analysis to assess body fluids. after a 15-minute rest period, the tests will be repeated to obtain an initial baseline control assessment. the subsequent sessions will involve the same evaluations, which will be conducted before, immediately after, and 15 minutes after the proposed intervention. the proposed interventions will be randomized across the sessions and will alternatively include: a brief session of static stretching on the leg muscles (4 sets of 30 seconds with 15 seconds of rest between sets), a session of static foam rolling (4 sets of 30 seconds with 15 seconds of rest between sets) on the same muscle groups, where pressure is applied to the muscle through the participant's body weight on a foam roller while performing muscle contractions, or dynamic foam rolling, during which the muscle will be rolled over the foam roller.


Eligibility criteria:
inclusion criteria: healthy participants, adult participants, active, agreeing to sign the consent form exclusion criteria: participants with neuromuscular, orthopedic and gynecological disease (or taking oral contraceptives) or those having injuries of the lower extremities were excluded from the investigation. female participants were allowed to participate to the experiments only during the follicular phase of their menstrual cycle and always before ovulation

Keywords: stiffness jump pain sensitivity eim l-bia
role of pain modulation in gerd patients who failed standard dose proton pump inhibitors (ppi)

Conditions: Gastroesophageal Reflux Disease

Summary: the main objective of this study is to evaluate the role of pain modulation in gerd patients who fail to obtain clinical relief with standard dose (once daily) ppi. the study will compare the efficacy of 1) standard dose ppi plus low-dose tricyclic antidepressant (tca) to, 2) double dose ppi to, 3) standard dose ppi and placebo to determine the relative symptom resolution and health related quality of life in gerd patients who fail standard dose ppi and are randomly assigned to one of these three groups.

to evaluate the role of pain modulation in gastroesophageal reflux disease(gerd)patients who fail to obtain clinical relief with standard dose (once daily) proton pump inhibitor(ppi). the study will compare the efficacy; of 1)standard dose ppi plus low-dose tricyclic antidepressant (tca) to, 2) double dose ppi to, 3) standard dose ppi and placebo to determine the relative symptom resolution and health related quality of life in gerd patients who fail standard dose ppi and are randomly assigned to one of these three groups.

Eligibility criteria:
inclusion criteria: * male or female * ages 18 to 75 * at least two episodes of heartburn per week while on ppi once daily * able to communicate with the investigator and comply with the requirements of the study * subjects who give written informed consent after being given a full description of the study. exclusion criteria: * known allergy or intolerance to tca * use of antidepressant or a diagnosis of depression * history of serious arrhythmia or use of anti-arrhythmics * history of seizures * subjects with significant co-morbidity, e.g., cardiovascular, respiratory, urogenital, renal, gastrointestinal, hepatic, hematologic, endocrine, neurologic or psychiatric. * evidence or history of drug abuse within the past 6 months * erosive esophagitis, esophageal ulceration, peptic stricture, barret's esophagus, or adenocarcinoma of the esophagus on endoscopy. * history of esophagogastric surgery * gastric or duodenal lesions (ulcer, tumor, etc) * women who are pregnant or of childbearing age who are not on contraception * patients who are unwilling or unable to provide informed consent

Keywords: acid reflux studies efficacy of ppi therapy failing ppi therapy gerd acid reflux disease
evaluation of a video-based media series to promote effective parenting

Conditions: Childhood Disruptive Behavior Problems

Summary: researchers are developing and experimentally evaluating two variants of a 10-episode, brief (12 minutes per episode), infotainment-style television series targeted at parenting practices, to determine the potential value of television for bringing evidence-based parenting practices to parents. the study compares an "information-only" version of the television series against an "enhanced" version that is designed to actively promote parents' adoption of the targeted strategies. both versions of the series are compared against a waitlist control group. the media series is derived from the triple p positive parenting program.

the mass media, and television in particular, hold significant potential as part of a population-wide strategy for bringing evidence-based parenting practices to a broad range of parents experiencing challenges raising their children. the potential of television for affecting parenting has received very little research attention, however; thus, little is known about how media messages to affect parenting practices might be optimally designed. this study will develop and experimentally evaluate two variants of a 10-episode, brief (12 minutes per episode), infotainment-style television series targeted at parenting practices, derived from the triple p-positive parenting program (sanders, 1999). a sample of 300 families of children ages 3-6 years with somewhat elevated disruptive behavior problems will be randomized to (a) receive a standard "information-only" version of the series that includes only modeling and demonstration of target parenting skills, (b) receive an enhanced "behavior activation" version of the series designed to actively promote parental behavior change, through elements addressing attributions, self-efficacy and expectancies, social support, and emotional reactivity, or (c) a waitlist control group. measures of parents' parenting practices, cognitions, affect, and social support, and children's disruptive behavior problems, will be obtained at baseline, post-intervention, and 6-month follow-up. the relative efficacy of the standard and enhanced versions of the triple p media series in improving these outcomes will be examined, as well as moderators of these effects, such as baseline level of behavior problems and parental stress. this study will further our understanding of the potential value of television programming for improving parenting practices.

Eligibility criteria:
inclusion criteria: * parent(s) living with a child 3 to 6 years old * child scores 1 or more standard deviations above the mean on the eyberg child behavior inventory * english speaking * parent at least 20 years old exclusion criteria: * currently receiving any other structured parenting intervention (home visits, parenting classes, individual parent training, family therapy) * father-only households

Keywords: behavior problems children prevention television media parenting
clinical trial comparing carnoy's and gewf solutions for lymph node clearing technique in colorectal cancer

Conditions: Colorectal Neoplasms; Neoplasm Metastasis

Summary: regional lymph node metastasis is a major determinant of local recurrence and overall survival rates in patients with colorectal cancer. because of the poor prognosis associated with the presence of lymph node metastasis, stage iii colorectal cancer patients should receive adjuvant treatment with chemo and / or radiation therapy according to the site of tumor. several authors have investigated the use of revealing solutions for lymph node clearance in colorectal cancer. most studies comparing conventional histopathological specimen examination to any lymph node clearing technique showed that the use of revealing solutions increases the mean number of lymph nodes harvested, usually in a statistically significant manner. it is still controversial the impact of the use of revealing solutions for upstaging of lymph node status and consequently for the indication for adjuvant therapy. therefore will be conducted a randomized clinical trial to compares the performance of gewf and carnoy solutions for the histopathological examination of patients with colorectal cancer. the aim of this study is to determine the lymph node revealing solution with the best performance (increase in the mean number of lymph node harvested and lymph node upstaging) in patients with colorectal cancer.

patients with histologically proven colorectal adenocarcinoma submitted to curative resection and conventional histopathological examination of the surgical specimen are randomized to undergo further investigation by lymph node clearing technique with carnoy or gewf solution.

Eligibility criteria:
inclusion criteria: * histologically proven colorectal adenocarcinoma * voluntary agreement of the patient to participate in research * voluntary agreement of the surgeon to participate in research exclusion criteria: * absence of accurate histopathological data

Keywords: neoplasm metastasis colorectal neoplasms lymph nodes lymph node revealing solution
interpersonal therapy-based treatment to prevent postpartum depression in adolescent mothers

Conditions: Postpartum Depression

Summary: the specific aim of this study is to conduct a randomized controlled trial to evaluate whether project reach (an interpersonal psychotherapy-based intervention) compared with a didactic attention-control program reduces the risk of ppd in adolescent mothers. primary hypothesis: 1. the intervention (project reach) will be significantly more efficacious than the control program in reducing the risk of ppd up to six months postpartum in adolescent mothers. secondary hypotheses: 2. the decreased rate of major depression in the project reach group compared to the control program group will be sustained through one year postpartum. 3. adolescent mothers in project reach compared to the control program group will have higher levels of maternal-child bonding.

each year, more than 400,000 births in the united states are to mothers less than 20 years old. alarmingly, approximately 25-36% of teen mothers experience postpartum depression (ppd), a condition associated with significant social and health morbidity. ppd places teen mothers and their children at great risk during an already challenging time in their lives. preventing ppd in this vulnerable population is essential to improving overall health. project reach is a randomized controlled trial, to evaluate whether our novel preventive intervention compared to a didactic attention control reduces the risk of ppd in adolescent mothers. the intervention, reach (relax, encourage, appreciate, communicate, help), is based on interpersonal psychotherapy (ipt) and targets those factors that may play a significant role in the development of ppd in adolescent mothers (i.e., poor social support, role transitions and life stressors). the control condition includes didactic prenatal education sessions. project reach builds on the foundation of our nimh-funded treatment development project and pilot study (r34 mh077588). the pilot study demonstrated feasibility, acceptability and initial efficacy in a small sample. the current r01 proposal aims to evaluate the efficacy of the project reach intervention in reducing the risk of ppd.

Eligibility criteria:
inclusion criteria: * less than 24 weeks pregnant * not currently being treated for depression * speaks and reads english fluently exclusion criteria: * currently receiving mental health services from a health care provider * meets dsm-iv criteria for an affective disorder, substance use disorder, or psychosis

Keywords: randomized trial postpartum depression adolescent pregnancy interpersonal psychotherapy
impact of using an hemodynamic monitoring system on anesthetic consumption during abdominal surgery

Conditions: Hypotension During Surgery

Summary: in this study investigators will study the association between the use of an hemodynamic monitoring system and the anesthetic consumption in patients following major abdominal surgery. investigators will randomise patients for a control group and an intervention group. patients belonging to intervention group will be monitored with a non-invasively continue system (acumen iq cuff sensor), while the control group will be monitored with a non-invasive intermittent pressure system. the total amount of ml of sevoflurane will be registered in both groups and the difference will be considered as the aim of our study


Eligibility criteria:
inclusion criteria: * over 18 years of age * signature of informed medical consent exclusion criteria: * bmi\> 30 * egfr\<30 * nyha iii-iv * severe cardiac valvular diseases * absence of informed medical consent

Keywords: anestethic comsumption hemodynamic monitoring
plant-based ingredient on post prandial glucose in type ii diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: effects of a plant based ingredient on blood glucose in type ii diabetes patients.

the study is designed to determine the extend to which a plant based ingredient in a food format affects blood glucose responses in untreated type ii diabetes patients.

Eligibility criteria:
inclusion criteria: * male and female volunteers with confirmed type ii diabetes not treated with pharmaceutical-based glucose lowering treatment for past three months (controlled solely through diet and exercise); * age ≥ 20 and ≤ 65 year at screening; * body mass index (bmi) between ≥18 and ≤ 32 kg/m2; * hba1c ≥48 mmol/mol and ≤53 mmol/mol (≥ 6.5% and ≤ 7.0%). at discretion of the study physician, subjects with hba1c \>53 mmol/mol and \ 7.0% and \< 7.5%) controlled solely through diet and exercise are also allowed to participate. exclusion criteria: * being an employee of unilever or research site; * chronic smokers, tobacco chewers and drinkers; * no medication, including vitamins and tonics, except for cholesterol, as determined by the physician; * reported weight loss/gain ≥ 10% of body weight in the 6 months preceding screening; * allergy to any food or cosmetics; * if female, not being pregnant or planning pregnancy during the study period; * if female, lactating or has been lactating for 6 weeks before pre-study investigation and/or during the study period.
the stop unhealthy substance use now trial

Conditions: Risky Health Behavior; Substance Use Disorders; Substance Abuse; Alcohol Use Disorder; Drinking, Alcohol; Substance Use

Summary: the stop unhealthy (stun) substance use now trial (stun ii) is a multisite trial aiming to evaluate the comparative effectiveness of the following strategies for improving the implementation of screening and interventions for substance use disorders in primary care: practice facilitation (pf), pf plus a learning collaborative (lc), pf plus performance incentives (pi), and pf+lc+pi. we plan to enroll 144 clinic staff participants from 48 primary care practices

the stop unhealthy (stun) substance use now trial (stun ii) is a multisite trial aiming to evaluate the comparative effectiveness of the following strategies for improving the implementation of screening and interventions for substance use disorders in primary care: practice facilitation (pf), pf plus a learning collaborative (lc), pf plus performance incentives (pi), and pf+lc+pi. we plan to enroll 144 clinic staff participants from 48 primary care practices specific aim 1 (primary aim) will compare the effect of learning collaborative (lc) participation, performance incentives (pi), or their combination, with practice facilitation (pf) only, on implementation of evidence-based screening for suds. specific aim 2 (secondary aim) will compare the effect of lc participation, pi, or their combination, with pf only, on implementation of evidence-based interventions for suds, including (a) brief counseling, (b) medications (e.g., buprenorphine, naltrexone) and adherence to them, and (c) referral to specialty care. specific aims 1 and 2 will produce fundamentally important evidence about the comparative effectiveness of pf, pf+lc, pf+pi, and pf+lc+pi strategies on uptake of evidence-based screening and interventions for sud when delivered to primary care practices. specific aim 3 (exploratory aim) will use a longitudinal mixed-methods evaluation to assess the association between implementation effectiveness and putative moderators (e.g., organizational readiness for change) and mediators (e.g., implementation climate). aim 3 will generate scientific knowledge about mechanisms of change (why and how the various strategies work) in primary care settings.

Eligibility criteria:
inclusion criteria: * clinic staff members from primary care practices who provide care for adult patients and have a leadership role within the practice (e.g. lead physician, practice manager, lead medical assistant/nurse, clinical champion) exclusion criteria: * clinic staff members who already have ongoing involvement in programs that would conflict with or preclude this study