Kornimate/medical-research-clean huggingface dataset:
individualised gait modification strategies in alkaptonuria patients

Conditions: Alkaptonuria

Summary: this study evaluates the efficacy of a gait modification intervention using real-time biofeedback on reducing the knee joint loading in alkaptonuria patients during treadmill walking. it will also assess whether the individualised adopted gait modification can be retained without feedback and during over ground walking.

alkaptonuria (aku) is a degenerative disease affecting the cartilage of the joints. the disease affects movement function, particularly walking/gait which is an important activity of daily living. it is believed that increased joint loading measured by the moments acting upon the joints, contributes to the degeneration of joint cartilage in alkaptonuria, particularly in the weight bearing joints such as the knee and hips, resulting in accelerated progression of painful symptoms. currently there is no cure for alkaptonuria and the current management includes joint replacement surgery. gait modification strategy interventions could be a non-invasive alternative which could delay the time to surgical interventions by reducing or altering joint loading and stalling the progression of disease. the aims of this study are 1) to determine if individualised gait modification strategies can be used to reduce the 3d knee joint loading, 2) to determine if the gait modifications can be retained without feedback during over ground walking and 3) to determine the individualised gait modification strategies adopted by aku patients. gait data will be measured and quantified using the non-invasive typical clinical gait analysis set up, using 3d motion capture combined with force data whereby joint angles, moments and powers can be calculated in all 3 planes of motion during treadmill walking. the intervention will involve real-time biofeedback using motek's m-gait treadmill. due to the heterogeneity of the sample, each aku patient will act as their own control. gait data will be compared pre- and post-intervention and a validated pain score will be used to identify any patterns with knee pain and adopted gait modifications.

Eligibility criteria:
inclusion criteria: * the diagnosis of alkaptonuria * able to understand written and spoken english. * willing and able to give informed consent to participate * above the age of 18. exclusion criteria: * the reliance on or use of a walking aid. * any previous lower limb joint replacements. * any severe pain or unable to walk comfortably and consecutively for 20 minutes. * pregnant
comparative, randomized study on the anti-inflammatory and regenerative efficacy of a new medical device (dm) based on hydrolyzed collagen peptides in patients with femoro-acetabular impingement undergoing hip arthroscopy

Conditions: Femoroacetabular Impingement; Hip Arthroscopy; Hip Osteoarthritis; Hydrolyzed Collagen Peptides

Summary: hip osteoarthritis (hoa) is the most common joint disorder and a major cause of disability in the adult population. thus, the early diagnosis, prevention, and treatment of the early stages of the disease and of the pre-arthritic condition, in particular in adolescents and young adults, is crucial to reducing the incidence of end-stage hoa and the need for total hip replacement (thr). evidence has mounted for a prominent etiologic role of femoroacetabular impingement (fai) in the development of early hoa leading to the development of early cartilage and labral damage in the non-dysplastic hip. therefore, the surgical treatment of fai with mini-invasive arthroscopy is crucial. to improve the outcome after surgery, cortisone is routinely injected during the procedure for anti-inflammatory purposes. the aim of the study is to compare the use of cortisone (gold-standard) (c) to a new class iii medical device based on hydrolysed collagen peptides pep-52, peptys (p) and to investigate potential associations among the preoperative symptoms and hip function, the outcomes after arthroscopic surgery and biomarkers in synovial fluids (sfs).

patients scheduled for hip arthroscopy for treatment of fai and/or labral pathology will be enrolled. the two treatments, c or p, will be administrated to patients with random sampling. sfs samples, when available, are obtained by aspiration just prior to surgical intervention, collected and stored for biomarkers analysis. at the baseline, oa severity will be assessed with a radiographic scoring system (tönnis classification). physical examination and clinical assessment using the hip disability \& osteoarthritis outcome score (hoos) and vas score for pain will be performed at the time of surgery and at 1-6 months of follow up. at the time of surgery, chondral (outerbridge score) and labral pathology based on direct arthroscopic visualization will be also evaluated. the presence of inflammatory molecules at the baseline in the sfs will be also evaluated.

Eligibility criteria:
inclusion criteria: * candidates for hip arthroscopy for femoroacetabular impingement (fai) * ability to provide informed consent exclusion criteria: * inability to provide informed consent; * patients suffering from cancer or with poor general health conditions; * patients suffering from coagulation diseases; * positive history of tumor, infection, rheumatic or metabolic disease in the joint undergoing surgery; * systemic inflammatory rheumatic diseases; * pregnant or breastfeeding women; * patients with proven hypersensitivity to collagen of bovine origin or vitamin c.
oxidative stress in response to electroacupuncture against physical activity in diabetic patients

Conditions: Diabetes Mellitus, Type 2

Summary: os is an important pathogenetic mechanism for the development of t2dm and its complications. oxidative stress is an imbalance of the generation of free radicals or known as reactive oxygen species (ros) and reactive nitrogen species \[rns\]) and their neutralization by the antioxidant mechanisms. increased levels of ros and rns lead to damage of lipids, proteins, and dna, ultimately causing the destruction of the islet cells of pancreas through apoptosis . elliptical trainer device is a relatively new modality of exercise and is advertised to be superior to a treadmill because of the low joint impact and the more reasonable costs of an elliptical trainer compared to a treadmill . additional quantative research is needed to further evaluate the effectiveness of elliptical trainers and the physiological and perceptual responses to the machine electroacupuncture (ea) is a treatment form of traditional acupuncture in which small electrical currents are passed through needles inserted into the subject's skin using ea stimulator. it seems to have more acceptable results and effects on many important clinical applications and medical research sets .

60 diabetic patients will be randomly divided to electroacupucture group (30 patients) and high intensity elliptical training (30 patients). the treatment will be done for 5 sessions per week for 12 weeks

Eligibility criteria:
inclusion criteria: * type 2 diabetic elderly * body mass index less than 30 kg/m2. * fasting blood more than 126 mg/dl exclusion criteria: * cardiac patients * renal patients * respiratory patients * liver patients * patients who received any complementary therapies within 3 past months
factors of importance for the subjective and objective burden of informal caregivers to patients with functional psychoses - a descriptive and comparative study

Conditions: Functional Psychoses; Informal Caregivers

Summary: the objective is to find determinants for the subjective and objective burden of informal caregivers to patients who are requiring continued antipsychotic treatment for functional psychoses among factors related to the patient, the health care and support provision system and the informal caregiver him/her-self.

the study also comprises a descriptive part with the aim: * to describe clinical characteristics, symptoms, and functioning in the patient group. * to describe patient resource use in terms of support from the health care and social care sector. * to describe the socio-economic situation, the general and psychological health, and the coping ability of the informal caregivers.

Eligibility criteria:
inclusion criteria: * provision of informed consent * patients, male or female, aged 18 years or more, suffering or having suffered from a psychotic episode and being in need of continuous antipsychotic medication. * the respective patient must have at least one informal caregiver. * subjects (patients and informal caregivers) must be able to read and write. exclusion criteria: * diagnosis of dementia and such cognitive impairment which makes self assessments even with assistance unreliable (patients and informal caregivers). * involvement in the planning and conduct of the study (patients and informal caregivers). * other concurrent medical condition interfering with ability to complete study (patients and informal caregivers).

Keywords: caregiver burden
current trend of epidemiology of psychiatric emergency and the stress of duty psychiatric resident

Conditions: Emergent Psychiatric, Consultation, Residentship

Summary: agitation, paranoia, and suicide risk of the psychiatric patients made them difficult to be managed when they visited medical emergency services. the prolonged waiting time at medical emergency services and the stigmatization of psychiatric medicine also made the psychiatric emergency services full of challenges. however, in recent years, the random killings, celebrity suicide and other major social events attracted much attention to the emergency psychiatry. following the establishment of the national health insurance, the law of mandatory admission, and the prevalence change of all psychiatric diseases, we are now dealing with totally different types of emergent psychiatric conditions, i.e., depression and suicide. however, the real epidemiological data need to be updated. psychiatric emergency is one of the entrances of the psychiatric network. a comprehensive review of the psychiatric emergency would be needed for the base of further research. this study is aimed to investigate the prevalence of psychiatric diagnosis of patients who came to emergency department of national taiwan university hospital and needed a psychiatric consultation. the epidemiological data will be compared to those collected 30 years ago in the same hospital to examine the 30-year trend. on the other hand, the visiting time and the staying time will be analyzed. the stress of on-duty and the contributing factors will be assessed by a 2-hour in-depth interview with psychiatric residents.


Eligibility criteria:
inclusion criteria: * psychiatric resident in ntuh exclusion criteria: * major psychiatric illness
study on two different formulations of 6-mercaptopurine. tablet versus oral liquid

Conditions: Acute Lymphoblastic Leukemia; 6-mercaptopurine Therapy

Summary: acute lymphoblastic leukemia (all) accounts for 30 % of all childhood malignancies. the patients undergo four phases of treatment, finishing with a late maintenance phase in which 6-mercaptopurine and methotrexate are essential components. insufficient treatment intensity in this phase is associated with increased risk of relapse. excessive variation in the bioavailability of 6-mercaptopurine has been observed which can cause both risks of undertreatment/relapse as well as overtreatment with severe side effects. in the attempt to achieve individualized 6-mercaptopurine dosing different approaches have been pursued. nonetheless variation in bioavailability remains a problem. earlier, oral tablets of 50 mg (purinethol) were the only administration form of 6-mercaptopurine and it was primarily designed for adult patients. challenges with accurate dosing and getting the children to swallow the tablets have been a widespread problem, forcing the caregivers to divide or crush the tablets as well as having to administer different dosages over 2-3 days. due to these problems, an oral liquid formulation of 6-mercaptopurine (xaluprine) has been developed. however this oral liquid has only been tested on healthy adult volunteers, and not on the target group, childhood patients. this project will assess the bioavailability and plasma kinetics of oral liquid and tablet formulation of 6-mercaptopurine in children with acute lymphoblastic leukemia. the investigators hypothesize to observe comparable plasma kinetics, in children with acute lymphoblastic leukemia when treated with 6-mercaptopurine in the form of a tablet and oral liquid formulation, as previously observed in healthy adults.


Eligibility criteria:
inclusion criteria: * childhood acute lymphoblastic leukemia patients, age 0-18 years at diagnosis, treated at the department of pediatrics and adolescent medicine, rigshospitalet. * informed consent exclusion criteria: * none

Keywords: 6-mercaptopurine drug formulation
saccharomyces boulardii in irritable bowel syndrome

Conditions: Diarrhea Dominant Irritable Bowel Syndrome

Summary: various studies have been conducted in past using different strains of probiotics in evaluating ibs symptoms. the results are by no means consistent and the overall impact of probiotics in ibs remains unclear. however, recently o'mahony l et al have shown that bifidobacterium infantis 35624 alleviates symptoms in ibs; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine (il-10/il-12 ratio), suggesting an immune-modulating role for this organism, in this disorder.saccharomyces boulardii is a probiotic yeast that has been successfully used for the antibiotic induced diarrhea, prevent relapse of clostridium difficile and crohn's disease. it ameliorates intestinal injury and inflammation caused by a wide variety of enteric pathogens.we therefore plan a double-blind, randomized, placebo-controlled study to assess the effects of saccharomyces boulardii in improving symptomatology of diarrhea predominant ibs and its effect on quality of life. we also plan to assess the changes in the relative production of anti-inflammatory interleukin (il)-10 to proinflammatory cytokines (il-12, il-8 and tnfα).


Eligibility criteria:
inclusion criteria: 1. diarrhea-predominant ibs satisfying rome iii criteria. 2. adults aged 18-70 exclusion criteria: 1. pregnant and lactating females 2. inflammatory bowel disease and other systemic disease 3. patients on anti-diarrheal and antibiotics drugs 4. patients with any ongoing infection 5. not willing to participate 6. allergy to any of saccharomyces boulardii components 7. central venous catheter carriers 8. other probiotics e.g., lactobacillus and bifidobacterium

Keywords: ibs saccharomyces boulardii probiotics cytokine histology efficacy
"swallow my urine back" : inhibition of detrusor overactivity by swallowing maneuver

Conditions: Overactive Detrusor

Summary: the purpose of this study is to find out whether swallowing has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity (do).

consecutive patients with do will be included in this study. during urodynamics, the amplitude of the waves of do will be documented and compared. at the beginning of the 2nd wave, patients will be asked to perform 5 repetitive swallows. following each wave, patients will be asked to grade the severity of the urgency by a visual analogue scale (vas).

Eligibility criteria:
inclusion criteria: patients with do in filling cystometry * antimuscarinic medications were requested to stop for 7 days before the cystometry exclusion criteria: none

Keywords: urodynamics overactive bladder
feasibility of blood glucose control with the space tgc system in postoperative cardiac surgery patients in the icu

Conditions: Critical Illness

Summary: hyperglycemia is common in critically ill patients and associated with an adverse outcome. thus, glycaemic control is an important issue in critical care. despite extensive efforts of the intensive care unit staff difficulties were experienced in achieving efficient and safe glucose control. a fully automated algorithm may help to overcome some of these limitations by excluding intuitive interventions and integrating relevant clinical data in the decision-making process. space glucosecontrol (tgc system) is a decision support system which helps to achieve safe and reliable blood glucose control in the desired ranges. information on parenteral and enteral nutrition is automatically integrated into the calculations. the primary objective of the current study is to investigate the performance and usability of the space tgc system for glucose control over an extended glucose control range (4.4 to 8.3 mmol/l) in postoperative cardiac surgery patients.


Eligibility criteria:
inclusion: * age: \> 18 years of age * admitted following cardiac surgery * stay in the icu expected to be \> 20 h * blood glucose \> 6.7 mmol/l within 4 hours of icu admission or patient already on insulin treatment exclusion: * patients with hyperglycaemic crisis/ketoacidosis due to insulin deficiency. * known or suspected allergy to insulin * any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the patient (i.e., liver failure, other fatal organ failures) * patients participating in another study * moribund patients likely to die within 24 hours * patients after organ transplantation within the last three months * patients under high dose cortisol treatment (cortisol \> 1000 mg/day or equivalent doses of hydrocortisol)

Keywords: algorithm tight glycemic control glucose control intensive care insulin icu
efficacy and safety of mt-5199 in subjects with tardive dyskinesia

Conditions: Tardive Dyskinesia

Summary: the purpose of this study is to evaluate the efficacy and safety of mt-5199 administered once daily for the treatment of tardive dyskinesia (td) symptoms.


Eligibility criteria:
inclusion criteria: * have one of the following clinical diagnoses for at least 3 months prior to screening: schizophrenia or schizoaffective disorder, bipolar disorder, or depressive disorders. * have a clinical diagnosis of neuroleptic-induced td. * have moderate or severe td. * if using maintenance medication(s) for schizophrenia or schizoaffective disorder, or bipolar disorder, or depressive disorders, be on stable doses. exclusion criteria: * have an active, clinically significant unstable medical condition in screening period. * have a significant risk of suicidal or violent behavior. * have a known history of long qt syndrome or cardiac tachy-arrhythmia. * are currently pregnant or breastfeeding.
prognostic value of a diaphragmatic endurance test in patients with amyotrophic lateral sclerosis

Conditions: ALS (Amyotrophic Lateral Sclerosis)

Summary: amyotrophic lateral sclerosis (als) is a neurodegenerative disease which involves respiratory muscles and can lead at short term to respiratory failure. the occurrence of respiratory failure is associated with morbidity and an increased mortality. to date, respiratory muscle weakness is predicted from the reduction of vital capacity, maximal inspiratory force, nocturnal symptoms and hypercapnia. even taken together, the predictive value of these indices is low. the investigators hypothesize that an endurance test of diaphragmatic work would be more sensitive to respiratory muscle involvement than maximal respiratory force. consequently, the investigators assessed diaphragmatic performance through an isocapnic hyperventilation test (iht) in patients at the onset of als and, then regularly up to the occurrence of respiratory failure. the investigators make the hypothesis that iht will be altered earlier than maximal inspiratory force


Eligibility criteria:
inclusion criteria for patients : * older than 18 years old and younger than 80 years old * als patient seen during the diagnostic assessment inclusion criteria for control group : * older than 25 years old and younger than 80 years old * no respiratory or neurologic active pathology exclusion criteria for patients : * bulbar als (inability to perform maximal respiratory maneuvers) * dementia * respiratory failure at diagnosis (arterial carbon dioxide partial pressure (pco2) \> 45 mmhg) * respiratory or neurologic active pathology exclusion criteria for control group : * chest wall deformation with spirometric defect

Keywords: amyotrophic lateral sclerosis als diaphragmatic endurance test
clinical trial of gaia-102 for advanced and relapse nsclc

Conditions: Cell Therapy; NSCLC

Summary: phase i part : confirm the safety of gaia-102 alone or gaia-102 with pembrolizumab for advanced / relapse non-small cell lung cancer, and decide recommended dose for phase ii. phase ii part : explore the efficacy and safety of gaia-102 alone or gaia-102 with pembrolizumab for advanced / relapse non-small cell lung cancer at the recommended dose of gaia-102 decided in the phase i part.

phase i part : the gaia-102 cohort (level a1\~a3) and the gaia-102 + pembrolizumab cohort (level b1\~b3) will be implemented in a 3 + 3 design. first, start from level a1 and set the dlt evaluation period until day 28 of cycle 1, and confirm the safety up to cycle 1_day 28 of level a1. after that, level a2 and level b1 will be started in parallel. after that, unless mtd is recognized, the safety at each level will be confirmed in sequence, and the recommended doses of phase ii part will be determined. phase ii part : at the recommended number of doses confirmed in phase i part, 20 patients will be administered up to 3 cycles, and the safety and efficacy of gaia-102 alone or with pembrolizumab will be evaluated by orr.

Eligibility criteria:
inclusion criteria: 1. patients who have been confirmed to have nsclc by histological or cytological examination 2. patients with ecog performance status (ps) 0-1 at the time of obtaining consent 3. patients aged 20 years or older at the time of obtaining consent exclusion criteria: 1. patients with symptomatological cranial nerve system metastasis. if treatment for cranial nerve system metastasis has already been performed and the neurologically recovered state has been maintained for 2 weeks or more before registration, registration is possible. 2. patients diagnosed with cancerous meningitis 3. patients who received allogeneic hematopoietic stem cell transplantation 4. patients with active autoimmune disease