Kornimate/medical-research-clean huggingface dataset:
mediolateral episiotomy and obstetric anal sphincter injuries in instrumental delivery

Conditions: Obstetric Anal Sphincter Injury; Episiotomy Wound; Anal Incontinence; Pelvic Floor Disorders; Depression

Summary: literature is contradictory about the impact of mediolateral episiotomy during operative vaginal delivery in obstetric anal sphincter injuries prevention explaining the absence of international guidelines. the investigators consider that a randomized trials does not appears feasible for both ethical and practical reason and so we suggest a large national observational study. the investigators will include all nulliparous women that underwent an operative vaginal delivery within the 72h following the delivery at more than 34 weeks of amenorrhea. the investigators will collect data about the history of pregnancy, the course of labor, the mode of delivery, maternal immediate and one-year morbidity, neonatal immediate morbidity. the investigators expect a one-year study in 129 recruiting center with 15000 included women. the primary objective is to assess the protective effect of mediolateral episiotomy against obstetric anal sphincter injury during instrumental delivery in nulliparous women according to the type of instrument used. the secondary endpoints are to investigate the effect of mediolateral episiotomy on one-year maternal morbidity, immediate maternal morbidity. the investigators also aim to develop a clinical score to assess the absolute risk of obstetric anal sphincter injury during instrumental delivery. finally, the investigators will investigate the impact of fetal presentation ultrasound assessment immediately before instrumental delivery on the mode of delivery.


Eligibility criteria:
inclusion criteria: * age of 18 years or older * nulliparity and instrumental delivery of a singleton in cephalic presentation in the previous 72 hours including failure of vaginal instrumental delivery leading to cesarean section exclusion criteria: * expression of any opposition or objection to study participation * previous delivery of a fetus at a gestational age greater than 20 weeks, regardless of the mode of delivery * preterm birth before 34 weeks of amenorrhea * fetal presentation other than cephalic * multiple pregnancy * in utero death * inability to understand french * under judicial protection * without access to a numeric terminal with internet connexion
efficacy and safety of bilateral theta burst stimulation for the treatment of auditory hallucinations

Conditions: Auditory Hallucinations

Summary: first clinical studies indicate an effect of repetitive transcranial magnetic stimulation(rtms) in the treatment of auditory hallucinations (ah). however, effect size, optimal stimulation site and parameters are unclear. with this randomized, placebo-controlled clinical trial we test the efficacy and safety of bilateral continuous theta burst stimulation (ctbs), a patterned form rtms, against auditory hallucinations. the treatment will be applied add-on to individual antipsychotic and behavioral therapy. patients will be treated for 6 weeks each weekday (30 sessions) with 40s of ctbs (halfway between t3/p3 and t4/p4). for weeks 1-3, half of the subjects will be randomized to a sham-stimulation (coil tilted 45°). during weeks 4-6, all subjects receive real ctbs.


Eligibility criteria:
inclusion criteria: * auditory hallucinations at least once a week * schizophrenia (dsm-iv) * stable treatment setting (in- or out-patient) * no change of antipsychotics during and at least 1 week before treatment initiation exclusion criteria: * epilepsy * benzodiazepines \> 1,5mg lorazepam / d * pregnancy * metal parts in the brain * cardiac pacemaker * deep brain stimulation
autologous tumor-infiltrating lymphocyte (gt307) for treatment of patients with advanced colorectal cancer

Conditions: Adult

Summary: this study is a single arm, open design aimed at evaluating the safety and tolerability of autologous tumor-infiltrating lymphocyte (gt307) for treatment of patients with advanced colorectal cancer,while evaluating pharmacokinetic characteristics and efficacy assessment to determine the optimal biological dose (obd).


Eligibility criteria:
inclusion criteria: 1. voluntarily join the study, signed informed consent form， willing and able to comply with the study protocol; 2. age 18 to 70 years old; 3. advanced colorectal cancer that progresses after first-line chemotherapy； 4. eastern cooperative oncology group (ecog) performance status score of 0 or 1; 5. expected survival time of ≥ 12 weeks; 6. good function of vital organs; 7. subjects entering this study due to disease progression must have an imaging record of disease progression before tumor sampling; 8. at least one measurable target lesion that meets the definition of recist v1.1 after tumor sampling. exclusion criteria: 1. patients with uncontrollable tumor-related pain as judged by the investigator; participants requiring analgesic medication must already have a stable analgesic regimen at the time of study entry; symptomatic lesions suitable for palliative radiotherapy should be completed prior to study entry; 2. known mental illness, alcoholism, drug use or substance abuse; 3. pregnant or lactating women; or women who are pregnant, breastfeeding, or planning to become pregnant within 1 year after cell infusion; 4. those who have received other clinical trial drug treatment within 4 weeks before preconditioning by lymphodepletion,plan to participate in other clinical trial drug treatment during the study; 5. the investigators determine that other conditions that make the patient not suitable for enrollment
investigation of the effects of pilates training combined with whole body vibration on balance and mobility in individuals with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the aim of this study is to investigate the effects of pilates training combined with whole-body vibration (wbv) on balance and mobility in individuals with multiple sclerosis (ms). the main questions it aims to answer are: * are the improvements in core stability, lower limb functional muscle strength, balance and mobility obtained with pilates training combined with wbv (pilates-wbv) in individuals with ms greater than with pilates training alone? * are the improvements in upper extremity performance and fatigue obtained with pilates-wbv training in individuals with ms greater than with pilates training alone? researchers will compare pilates-wbv training with a group that received pilates training alone to see if there is any additional benefit. participants will: * take pilates-wbv or pilates training twice a week for 6 weeks * be evaluated with pre- and post-training


Eligibility criteria:
inclusion criteria: * definitive multiple sclerosis diagnosed by a specialist * expanded disability status scale (edss) score between 0-5 * accepting participation in the study voluntarily exclusion criteria: * an ms attack within the last three months * pregnancy * endoprosthesis or electronic implant * a cardiovascular, pulmonary or orthopedic disease * a disease that can affect the immune system, such as infection or cancer * additional neurological disease

Keywords: balance multiple sclerosis mobility pilates vibration
noninvasive intratumor heterogeneity evaluation in hnscc

Conditions: Head and Neck Cancer

Summary: this study focuses on tumor heterogeneity, a core challenge in the field of oncology, and innovatively utilizes patient imaging data to deeply mine and analyze intratumoral heterogeneity. by constructing an imaging analysis model for tumor heterogeneity and associating this model with clinical, pathological, transcriptomic, and metabolomic data of patients, a multi-omics decoding of tumor heterogeneity is achieved. the main questions it aims to address are: can the ith model stratify patients' treatment efficacy and prognosis assessment? can pathological and multi-omics sequencing map the mechanisms behind the ith model?


Eligibility criteria:
inclusion criteria: pathologically confirmed head and neck squamous cell carcinoma (hnscc). complete clinical, imaging, and pathological data. available complete follow-up information. exclusion criteria: patients who received chemotherapy or radiotherapy before surgery. poor image quality. tumors too small to be easily identified. history of other concurrent malignant tumors.
sigil: signal interpretation and analysis in real life cardiac arrhythmias

Conditions: Cardiac Arrhythmia

Summary: this study essentially consists of the prospective collection of mapping data derived from patients undergoing clinically indicated 3d mapping procedures. there is no intervention. the mapping data is used to construct and/or validate new activation mapping algorithms but will not be used to direct clinical treatment of the patient.

cardiac arrhythmias are a common clinical problem in cardiology. often, such arrhythmias can be effectively and permanently treated through catheter ablation. a key technology enabling the success of catheter ablation is activation mapping of cardiac arrhythmias. this refers to the construction of maps which depict the sequential activation of the cardiac chamber of interest. it is a fundamental electrophysiology technique, but at the same time, the principles behind activation map construction have not changed for decades. in brief, the way activation maps are constructed nowadays consists of the following steps: (i) sequential acquisition of voltage signals throughout the cardiac chamber of interest, recording both the signal together with the location of the signal in 3d space (ii) local activation time annotation of each of the acquired signals in relation to a so-called timing reference (iii) depiction of the annotated activation time graphically as a so-called activation map, through which the mechanism of the arrhythmia can be understood and an appropriate ablation target chosen following assignment of the lat to each individual signal, the map is complete and can be used to discern the arrhythmia circuit to choose an appropriate ablation target. the objective of this study is to develop, refine and validate lat-independent methods of activation map analysis using mapping data acquired from patients undergoing clinically indicated ep mapping and ablation procedures. specific objectives: (i) electrogram signature analysis. to use machine learning techniques to identify electrogram properties associated with specific conduction patterns. (ii) intracardiac egm summation. to integrate all acquired points into a global function that allows as precise a determination as possible of the period of isthmus conduction in re-entrant arrhythmias. (iii) conduction velocity estimation. to algorithmically determine conduction velocity using proprietary techniques to wholly or partially reduce reliance on lat annotation.this study aims to collect the electroanatomic 3d maps from patients to develop novel mapping algorithms, but this map data is not used to direct clinical treatment.

Eligibility criteria:
inclusion criteria: 1. patient undergoing a clinically indicated 3d mapping procedure for a cardiac arrhythmia 2. ability to provide informed consent exclusion criteria: * patients who cannot provide informed consent will be excluded. otherwise, there are no specific exclusion criteria.
safety, feasibility and effect of an individualized physical activity intervention for gastric cancer patient undergoing minimally invasive gastrectomy: a pilot study

Conditions: Gastric Cancer Patient

Summary: gastric cancer is a major health issue and one of the most common malignance in korea. with the popularization of cancer screenings and increasing the average lifespan, the number of gastric cancer patients is increased. in the past, most of the research were concerned with survival and recovery after cancer surgery. however, as the medical technology had been developed and recovery rate and survival rate of cancer patients had risen, the patients wanted to return to a daily life and desire for participation for leisure. in other words, the patients who underwent surgery wants to maintain a high quality of life(qol) level as like prior to cancer surgery. there are many reports on the effect of the exercise program after cancer surgery. in addition, exercise program was associated with improving the qol and functional recovery, decreasing a mood of depression, maintaining a muscle mass and improving the survival rate. however, the subject patients of previous studies were western people. therefore, the results were not disclosed whether the exercise program suited to the body characteristics of korean people. furthermore there was no exercise program studies for the gastric cancer patients. medical service for cancer patients care should include not only diagnosis, treatment as like surgery but efforts on enhancing the quality of life. in other words, post-management education and management program as like exercise program are necessary for the cancer patients after surgery. so, the research about how to practice the exercise program and how to evaluate the effect on the recovery is needed.


Eligibility criteria:
inclusion criteria: 1. early gastric cancer patients 2. undergoing minimally invasive surgery 3. age: 20-70 4. ecog: 0-1 5. a patient who did not exercise regularly for the last 6 months 6. a patient who signed the informed consent exclusion criteria: 1. pregnancy or plans to become pregnant 2. cognitive disabilities 3. other primary cancer history 4. history of major abdominal surgery except current surgery 5. cardiopulmonary medical comorbidity 6. living \> 60 km from the hospital

Keywords: gastric cancer, minimally invasive gastrectomy, physical activity intervention
circulating tumor cells screen for breast cancer

Conditions: Breast Neoplasm; Neoplastic Cells, Circulating

Summary: a prospective study was used to collect patients considering breast cancer admitted to our general surgery department from 2019-6 to 2023-8, to identify the case group (breast cancer) and the control group (non-breast cancer), to compare the differences in ctc in peripheral blood between the two groups, and to draw conclusions after statistical analysis.

this project is a prospective study by collecting clinical data from breast cancer and non-breast cancer patients admitted to our general surgery department from 2020 to 2023, and drawing peripheral blood for ctc testing. the clinical data of 200 patients were initially collected and grouped, with the study group positioned as breast cancer patients (patients with pathologically determined breast cancer) and the control group as non-breast cancer patients (patients with benign breast tumors and healthy women), to investigate the expression of ctc in breast cancer and correlation with the degree of metastasis, as well as to further understand the relationship between ctc in peripheral blood and breast cancer clinicopathology. the circulating tumor cell enrichment was compared between the two groups, and the data were derived for statistical analysis to draw conclusions, as well as to identify shortcomings and make improvements to the existing problems.

Eligibility criteria:
inclusion criteria: clinical diagnosis of breast cancer must be able to cooperate with the examination exclusion criteria: patients were currently undergoing or had prior cancer treatment; patients had other conditions which investigators thought not suitable for the study.

Keywords: breast cancer circulating tumor cells
auricular acupressure on improving pain and heart variability in patients after cervical spine surgery

Conditions: Auricular Acupressure; Cervical Spine Surgery

Summary: the primary objective of this study is to investigate the effectiveness of auricular acupressure in improving post-cervical spine surgery pain and heart rate variability in patients.

this study adopts a quasi-experimental research design, where a medical center in northern taiwan served as the enrollment location. both the experimental group and the control group received standard ward care. the experimental group commenced auricular acupressure intervention post-surgery. questionnaire assessments and heart rate variability measurements were conducted in the experimental group on the first, second, third, and fourth days before discharge. the control group did not receive auricular acupressure and underwent only questionnaire assessments and heart rate variability testing. measurement tools included the mcgill pain questionnaire and the heart master wrist-worn physiological monitor.

Eligibility criteria:
inclusion criteria: 1. those who are over 20 years old and have undergone cervical spine surgery. 2. those who have clear consciousness and can communicate in mandarin or taiwanese. 3. patients who have undergone cervical spine surgery and have no complications (such as wound infection or postoperative limb mobility impairment) disability). 4. those who are willing to cooperate with ear acupuncture and heart rate variability testing. 5. those who agree to participate in the research and sign the consent form. 6. the skin of the auricle is intact and has no deformation, defects or allergies.- exclusion criteria: 1. those who use self-controlled pain control (pca) after surgery. 2. those diagnosed with mental illness or cognitive impairment. 3. those who are transferred to the intensive care unit after surgery. 4. those who use breathing aids. 5. those with major chronic diseases, such as cardiovascular disease or cancer. 6. those who develop delirium after surgery.

Keywords: cervical spine surgery post-operative pain auricular acupressure heart variability.
effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy.

Conditions: Oxaliplatin-induced Peripheral Neuropathy

Summary: it is a phase ii trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. the trial population is composed of patients ≥18 years old that have developed stage ii/iii colorectal cancer and are eligible for simplified folfox4 (6-12 cycles) adjuvant chemotherapy. the primary objective is to assess the preventive efficacy of riluzole on the severity of oxaliplatin-induced peripheral neuropathy during the simplified folfox4 adjuvant chemotherapy of stage ii/iii colorectal cancers.


Eligibility criteria:
inclusion criteria: 1. patients aged ≥ 18 years old, 2. eligible patient starting adjuvant oxaliplatin-based chemotherapy (6-12 cycles, simplified folfox4) for stage ii/iii colorectal cancer, 3. histological or cytological confirmation of colorectal cancer, 4. performance status (ecog) ≤2, 5. normal hematological function (anc ≥1.5 x 10⁹/l; platelets count ≥100 x 10⁹/l; hemoglobin ≥9.0 g/dl), 6. normal hepatic function: total bilirubin ≤1.5 x upper limit of normal (uln) (unless documented gilbert's syndrome); aspartate aminotransferase (asat) and alanine aminotransferase (alat) ≤3 x uln, and gamma-glutamyltransferase (ggt) ≤3 x uln, 7. normal renal function: serum creatinine ≤1.5 x uln, 8. normal cardiac function: ecg, 9. patients affiliated to the french national health insurance, 10. patient must have signed a written informed consent form prior to any study specific procedures, 11. french language comprehension, 12. patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up. exclusion criteria: 1. metastatic cancer, 2. diagnosis of neuropathy, 3. eortc qlq-cipn20 sensory score \>6, 4. previous neurotoxic chemotherapy treatment, 5. patients with chronic obstructive pulmonary disease, 6. alat/asat elevated more than 3 times the normal value, 7. patients with known allergy or severe hypersensitivity to riluzole or any of the study drug excipients, 8. dependence on alcohol or drugs, 9. psychotic disorders, 10. women pregnant or breastfeeding, 11. patients undergoing a measure of legal protection (trusteeship, guardianship ...).

Keywords: riluzole oxaliplatin colorectal cancer neuropathy
efficacy of low dose of proton pump inhibitor in treatment bleeding ulcers

Conditions: Gastroduodenal Ulcer; Marginal Ulcer; Peptic Ulcer Hemorrhage

Summary: determining the efficacy of low dose of ppi in management acute peptic ulcer bleeding

determining the efficacy of low dose meaning 40 mg of omeprazole twice in management acute peptic ulcer bleeding

Eligibility criteria:
criteria: inclusion criteria: high risk ulcers defined according to the forrest classification with respect to high-risk stigmata, active bleeding was defined as a continuous blood spurting (forrest ia) oozing (forrest ib) from the ulcer base. a non-bleeding visible vessel at endoscopy was defined as a discrete protuberance at the ulcer base(forrest iia). an adherent clot was one that was resistant to forceful irrigation or suction (forrest iib). exclusion criteria: ulcer was malignant non ulcerative bleeding such as angiodysplasia , a mallory-weiss tear

Keywords: gastroduodenal ulcer marginal ulcer peptic ulcer hemorrhage peptic ulcer
the effect of relaxation techniques on earthquake survivors

Conditions: Earthquake; Mental Health Issue

Summary: the aim of this study is to investigate the effect of relaxation and breathing exercises on individuals experiencing post-earthquake stress-related symptoms.

earthquakes negatively affect survivors both physically and psychologically. early psychological symptoms after disasters are considered normal responses to an abnormal event. therefore, it is not unexpected to feel very intense negative emotions after such traumas. however, the chronicity of these negative emotions puts the lives of individuals at risk. mental problems such as stress, depression, posttraumatic stress disorder and anxiety are seen at high levels among earthquake survivors. in this study, it was aimed to investigate the effect of relaxation and breathing exercises applied to earthquake survivors who experienced post-earthquake stress-related symptoms. there are two gropus: relaxing exercise group and control group. relaxing and breathing exercise protocol is only for relaxing exercise group. a protocol consisting of 40 minutes of progressive muscle relaxation exercise and breathing exercises, 3 times a week for 4 weeks, was planned. control group participants were asked to continue their daily lives. evaluations were made before and 4 weeks after the intervention and stress-related symptoms were measured.

Eligibility criteria:
inclusion criteria: * individuals with a beck anxiety inventory score greater than 8 and anxiety experience for more than 1 month * individuals who experienced the earthquake of february 6, 2023 kahramanmaraş / türkiye and agreed to participate in the study * individuals without cognitive impairment * individuals who can understand and apply verbal commands in turkish exclusion criteria: * any history of psychiatric medication support for the last 6 months * any history of psychological problems before the earthquake

Keywords: earthquake physiotherapy breathing exercise relaxing exercise stress mental health