Kornimate/medical-research-clean huggingface dataset:
short-term ketogenic diet as compared with conventional long-term trial in refractory infantile spasms: a randomized, controlled study

Conditions: Infantile Spasms

Summary: this is a randomized, controlled study to compare short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.


Eligibility criteria:
inclusion criteria: 1. patients, who have recalcitrant infantile spasms and undertake the ketogenic diet at severance hospital and sanggye paik hospital from 2005 to 2008. 2. clinical and electroencephalography findings are compatible with infantile spasms 3. spasms are intractable to the initial combination of vigabatrin (150 mg/kg) and topiramate (10 mg/kg) and/or additional indicated anti-epileptic drugs including prednisolone (2 mg/kg for 2 weeks and an additional 2 weeks for tapering). 4. study entry requires magnetic resonance imaging to confirm the absence of a progressive cerebral lesion. exclusion criteria: 1. patients who have a history of hyperlipidaemia and underlying metabolic diseases including acute intermittent porphyria, pyruvate carboxylase deficiency, and fatty acid oxidation defects. 2. patients who have a history of nephrolithiasis.

Keywords: refractory infantile spasms
addressing post-covid-19 musculoskeletal symptoms

Conditions: Telemedicine; Musculoskeletal Disease; SARS-CoV-2; Pain; COVID-19; Exercise

Summary: the purpose of the study will be to evaluate the effect of a rehabilitation program on the improvement of patients with post-covid-19 musculoskeletal symptoms, as well as to quantify the impact of telemedicine that evaluates the evolution of pain, functionality, and quality of life.

a randomized clinical trial will be conducted in 100 patients with post-covid-19 musculoskeletal symptoms who will undergo a multicomponent rehabilitation program, together with an intervention and a follow-up using programmed telemedicine sessions. data will be collected on the improvement of functional capacity and quality of life, in addition to assessing the evolution of musculoskeletal symptomatology, as well as pain and psychological variables. the telemedicine sessions will improve user adherence and follow-up, and the results are expected to be disseminated to the scientific community during and after the end of the study.

Eligibility criteria:
inclusion criteria: * need to be post-covid-19 patients (icu or non-icu) * musculoskeletal symptoms * be of adult age (over 18 years) exclusion criteria: * myocardial infarction * uncontrolled arrhythmia * recent pulmonary thromboembolism * terminal illness * patients undergoing lower limb unloading * lower or upper limb fractures in the last three months * severe pain (score greater than 7 on the vas of 10 points) * suffering from the previous pathology that causes neuromuscular weakness * be younger than 18 and older than 65 years old * influenced by medication that does not allow assessment of the real muscular functionality of the patient * patients with cognitive impairment that would prevent them from understanding and collaborating in the performance of the rehabilitation program plus telemedicine * patients with cardiorespiratory instability and uncontrolled arterial hypertension * systemic illness (tumor and rheumatologic diseases) * recent unrelated trauma * limiting psychiatric pathology

Keywords: telemedicine sars-cov-2 rehabilitation therapeutic exercise
clasic laryngeal mask airway(c-lma) and i-gel releated regurgitation and complications

Conditions: Bladder Tumour; Prostate Hyperplasia

Summary: 1. i-gel 2. c-lma compare the effect on gastroeosephageal reflux postoperative complicatios.

120 asa i-ii adult patients. patients were randomised into two groups 1. i-gel 2. c-lma volume controlled ventilation, general anesthesia asses gastroeosephageal reflux, sore throat, coughing, dysphagia,dysphonia recorded.

Eligibility criteria:
inclusion criteria: * asa i-ii * adult * elective surgery * bladder tumour * prostat hyperplasi exclusion criteria: * emergency surgery * hiatal hernia * gastroeosephageal reflux disease

Keywords: i-gel c-lma gastroeosephageal reflux sore troat
feasibility and safety of acupuncture in the prevention of late irinotecan-related diarrhea in pediatric patients

Conditions: Pediatric Cancer; Solid Tumor

Summary: to evaluate the feasibility of an acupuncture protocol in the prevention of late diarrhea due to irinotecan in pediatric patients with solid tumors, a pre-post pilot study will be conducted. pre-post pilot study non-randomized, open label, single arm study. there will be a single study group that will be used at the same time as your own control. the intervention will take place for approximately one year.

pre-post pilot study non-randomized, open label, single arm study. the objective of this pilot study is to demonstrate that cancer acupuncture pediatric treatment is a safe and feasible treatment in the prevention of late-onset diarrhea related to with irinotecan. this pilot study will include patients between 0 and 18 years of age with a solid tumor (nephroblastoma, neuroblastoma, central nervous system tumors and rhabdomyosarcoma) receiving their first cycle of irinotecan, in our center, at 50 mg/m2/intravenous dose daily for five days (cumulative dose weekly = 250 mg/m2) and who do not receive concomitant abdominal radiotherapy. acupuncture will be applied as a complementary treatment along with the usual regimen of prophylaxis and treatment of late diarrhea.

Eligibility criteria:
inclusion criteria: * patients from 0 to 18 years old with solid tumors who start treatment in our center with irinotecan at 50 mg/m2/intravenous dose in day hospital. * blood tests prior to the start of the appropriate chemotherapy cycle to receive acupuncture with continuous stimulation needle insertion: neutrophils greater or equal to 1000 cells/mm3 and platelets greater than or equal to 50,000 cells/mm3. * signature of informed consent by parents in the case of children under 12 years of age and assent of the minor. * signature of informed consent in the case of those over 12 years of age exclusion criteria: * participate in a clinical trial that is developed in the pediatric oncology area of the hospital sant joan de deu where acupuncture intervention is not permitted. * have received acupuncture treatment in the last ten days. * receive concomitant abdominal radiotherapy. * have diarrhea on day 1 of the cycle

Keywords: cancer children diarrhea acupuncture irinotecan
comparison of maternal and neonatal vitamin d levels in term neonates with and without early onset sepsis

Conditions: Vitamin D Deficiency

Summary: neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life which is still an important cause of morbidity and mortality. vitamin d is a fat-soluble steroid hormone that primarily contributes to the maintenance of normal calcium homeostasis and skeletal mineralization. in addition to its classical role in bone metabolism, vitamin d also has immunomodulatory effects on immune function. although some studies reported a link between vitamin d deficiency and critical illness in adults, a direct relationship has not been directly shown yet. however, to the best of our knowledge, no study evaluated the association between eos and maternal/neonatal vitamin d levels. the objective of this prospective study is to determine the possible role of maternal and neonatal plasma vitamin d levels on eos development in term infants. we also aim to evaluate possible effect of the severity of vitamin d deficiency on eos development in the study population.

term infants with clinical and laboratory findings of early onset sepsis who are \>37 weeks of gestational age and will be admitted to neonatal care unit of kanuni sultan suleyman training and research hospital will be included in this prospective study. the study group will consist of term neonates who are clinically suspected to have an early infection from the 1st day of life. blood for neonatal and maternal vitamin d levels will be obtained from all infants and their mothers at the time of hospital admission. only infants with high probable sepsis will consist the study group. the healthy infants who admit to our outpatient clinic for routine evaluation at postnatal day 3 with no signs of clinical and laboratory infection and are evaluated for hyperbilirubinemia will be referred to as the control group. the control group wll consist term infants with the same gestational and postnatal age of the infants that will be included in the study group. in both groups, maternal samples will be obtained at the postpartum period at the time of infant's hospitalization. plasmas after separated and stored at -800c. levels of 25-ohd were determined using shimadzu lc-20at model high performance liquid chromatography (hplc) system. data will be analyzed using spss software and appropriate statistical analyses will be performed.

Eligibility criteria:
inclusion criteria: * infants \>37 weeks of gestational age and are admitted to neonatal care unit of kanuni sultan suleyman training and research hospital * infants with clinical and laboratory findings of early neonatal sepsis * term infants without sepsis as the control group exclusion criteria: * presence of maternal clinical and/or histological chorioamnionitis, * presence of premature rupture of membranes (prom), * infants with probable or possible sepsis according to criteria, * refusal of parental consent, * lack of laboratory data, * major congenital abnormalities

Keywords: vit d; sepsis; newborn; maternal; neonatal
treatment of partial-thickness rotator cuff tears

Conditions: Arthroscopic Surgical Treatment of High-grade (>50%) Partialthickness

Summary: the goal of this clinical trial is to demonstrate that regeneten is superior to standard repair techniques when surgically treating high-grade (\>50%) partial-thickness tears.

the objective of this study is to demonstrate arthroscopic surgical treatment of high-grade (\>50%) partial-thickness tears using regeneten yields statistically superior patient post-operative recovery outcomes, faster return to activities of daily living, and less health care utilization versus standard surgical repair techniques.

Eligibility criteria:
inclusion criteria: patients will be considered qualified for enrollment if they meet the following criteria: 1. male or female ≥18 years 2. high-grade (\>50% tendon thickness) partial-thickness tear 3. failed conservative medical management of the tendon tear defined as: 1. four (4) to six (6) weeks of formal physical therapy or guided home exercises 2. activity modification 3. shoulder injection at the discretion of the surgeon 4. able to comply with the post-operative physiotherapy and follow-up schedule 5. able to speak and read english provide written informed consent exclusion criteria: any one (1) of the following criteria will disqualify a patient from participation in the study: 1. prior shoulder surgery on index shoulder within 12 months of enrollment 2. failed primary rotator cuff surgery of the index shoulder 3. on steroids within 1 month of enrollment 4. metastatic disease 5. concomitant surgeries for bone defects requiring bone implantation (latarjet procedures) or for superior labral tear from anterior to posterior (slap) 6. concomitant biceps tenodesis 7. rheumatoid arthritis 8. advanced osteoarthritis 9. fatty infiltration of the index shoulder rotator cuff muscle ≥ grade 3 10. chronic pain disorders (i.e., fibromyalgia) 11. history of insulin dependent diabetes 12. history of heavy smoking (\> 1 pack per day) within 6 months of enrollment 13. currently involved in any injury litigation or workers compensation claims 14. hypersensitivity to bovine-derived materials medical or physical condition that, in the opinion of the investigator, would preclude safe participation in the study

Keywords: regeneten regeneten bioinductive implant highgrade partial thickness tear rotator cuff tear rotator cuff repair
quit2heal smartphone app in helping cancer patients quit smoking

Conditions: Hematopoietic and Lymphoid System Neoplasm; Malignant Solid Neoplasm

Summary: this phase iii trial compares the quit2heal smoking cessation smartphone application (app) to the quitguide app in helping cancer patients quit smoking. both apps provide tools to cope with urges to smoke, step-by-step guides for quitting smoking, help in planning for quitting and staying tobacco-free, and scientifically-based recommendations for how to select medications that aid in smoking cessation.

outline: patients are randomized to 1 of 2 arms. arm i: patients receive the quit2heal app and are encouraged to use it frequently. during the entire 12-month follow-up period, the app will remain fully available anytime study participants wish to use it. arm ii: patients receive the quitguide app and are encouraged to use it frequently. during the entire 12-month follow-up period, the app will remain fully available anytime study participants wish to use it. after randomization, patients are followed up at 3, 6, and 12 months.

Eligibility criteria:
inclusion criteria: * age 18 or older * diagnosed with cancer within the past 24 months or currently receiving or planning to receive cancer treatment in the next 3 months * smoked a cigarette (even a puff) in the past 30 days * interested in learning skills to quit smoking * willing to be randomly assigned to either smartphone application * live in the united states and will remain in the united states (us) for the next 12 months * have at least daily access to their own smartphone * know how to download a smartphone application * be willing and able to read english * not currently (i.e., within past 30 days) using other smoking cessation interventions * have never participated in our prior research trials * have never used the national cancer institute (nci)'s quitguide app * being willing to complete a follow-up survey at 3, 6, and 12 months post-randomization * providing email, phone number(s), and mailing address exclusion criteria: * currently (i.e., within past 30 days) using other smoking cessation interventions * has participated in our prior research trials * has used the nci's quitguide app * not willing to complete a follow-up survey at 3, 6, and 12 months post-randomization * not providing email, phone number(s), and mailing address
short message service in colonoscopy preparation (pericles-ii-sms)

Conditions: Colon Cancer

Summary: the purpose of this study is to analyze if integration of new media (sms) could improve the quality of colonoscopy preparation.

the study approach is the implementation of new media into colonoscopy preparation. as most of our patients already use mobile phones the study should evaluate if time adjusted information about diet recommendation, laxative intake and behavioral recommedation improve the patient compliance and the quality of colonoscopy preparation. in total 14 sms wil be sent to the study participants starting 4 days prior the colonoscopy appointment. no additional or different information is provided in comparison to regular colonoscopy preparation for out-patient colonoscopy. study participant are randomized when included into the study. group 1 receives a sms- supported colonoscopy preparation, group 2 receive no sms and prepares regularly. primary endpoint is bowel cleanness measured by boston bowel preparation scale, secondary endpoints are patient satisfaction, adenoma detection rate and compliance.

Eligibility criteria:
inclusion criteria: * over 18 years old * written informed consent * mobile phone user * appointment for outpatient colonoscopy exclusion criteria: * no outpatient colonoscopy * no mobile phone

Keywords: colonoscopy colonoscopy preparation screening new media sms short message service
long term follow-up of burn injuries

Conditions: Burn

Summary: the purpose of the study is to investigate the psychological effects of burn injuries as experienced by patients.

we are interested in determining how people adjust to burn injuries as a way of facilitating optimal recovery. this is done by conducting several questionnaires at the time of the discharge in the hospital, and later follow up with the patients up to two years.

Eligibility criteria:
inclusion criteria: * patients with more than a 30% total surface area burn * english speaking exclusion criteria: * patients with less than a 30% total surface area burn * non english speaking

Keywords: long term follow-up
evaluation of intestinal microbiota implication in ruptured intracranial aneurysm

Conditions: Intracranial Sacciform Aneurysm

Summary: the physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. the microbiota is known to interact with brain and can promote inflammation. the objective of this study is to describe microbiota with taxonomic and metabolomic analysis. a comparison between ruptured and unruptured intracranial aneurysm will be performed. the study hypothesis is that microbiota is different between ruptured and unruptured patient.


Eligibility criteria:
inclusion criteria: * one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group exclusion criteria: * transient modification of microbiota: antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like crohn), bmi for more than 30, very restrictive diet (like vegan * specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, type 1 neurofibromatosis, rendu-osler, marfan * participation to a study with the objective of microbiota modification

Keywords: intracranial aneurysm intestinal microbiota risk factor ruptured
improving clinical staging for muscle invasive bladder cancer through molecular profiling and improved imaging

Conditions: Bladder Cancer

Summary: the goal of this research study is to improve detection of cancer outside of the bladder through genetic testing and improved imaging.

if participant agrees to take part in the study, a piece of the tumor that is removed during the biopsy will be collected for research purposes. the tissue will be sent to the laboratory for genetic testing. if they have had a computed tomography scan (ct scan) or magnetic resonance imaging scan (mri) recently, information collected from the scan will be collected. if they have not had one recently, they will have an mri with contrast as part of this study. they will receive a separate consent form for this mri scan. the results of the test will be given to their doctor, but the results will not be used to decide their treatment. after they have surgery, information will be collected from their medical records, such as their diagnosis. length of study: * their participation on this study will be over once their surgery is completed. * this is an investigational study. up to 100 participants will take part in this study. all will be enrolled at md anderson.

Eligibility criteria:
inclusion criteria: 1. patients with biopsy proven bladder cancer of any age will be eligible for enrollment. exclusion criteria: 1. contraindication to pelvic mri (metallic implants/hardware, claustrophobia) 2. participants who have previously received chemotherapy as part of multimodal therapy.

Keywords: bladder cancer muscle invasive bladder cancer mibc biopsy specimen molecular profiling bladder surgery magnetic resonance imaging mri trans urethral resection of bladder
nalbuphine as an adjuvant to local anaesthetic mixture in peribulbar cataract surgery

Conditions: Nalbuphine as an Adjuvant to L. A in Peribulbar Block for Cataract Surgery

Summary: nalbuphine has been used as an adjuvant to bupivacaine in intrathecal, epidural, caudal anesthesia and peripheral nerve blocks showing an increase in the efficacy and the duration of postoperative analgesia.the aim of this study is evaluation of the effect of nalbuphine when used as an adjuvant to a local anesthetic mixture in peribulbar block undergoing cataract surgery

44 patients (22 in each group) scheduled for elective cataract surgery using peribulbar block. patients of group n received local anesthetics received 6 ml of 0.5% bupivacaine 1 ml hyaluronidase (75 iu), and 4mg of nalbuphine in 1 ml of saline (total 8 ml) and patients of group c received 6 ml of 0.5% bupivacaine, 1 ml hyaluronidase (75 iu) and1 ml saline (total 8 ml). addition of nalbuphine to bupivacaine in peribulbar block is associated with reduced the time of onset of globe akinesia, increased the duration of globe akinesia and analgesia with better postoperative pain relief

Eligibility criteria:
inclusion criteria: * patients aged 40-60 years. * both sex. * asa physical status ι\&ii. * patient with axial globe length below 26 exclusion criteria: * refusal of the patient to participate in the study. * coagulation abnormalities(inr\>1.4). * more than asa ii. * high myopia with axial length more than 26 mm. * mentally retarded patients and failure of proper communication as in deafness . * morbidly obese patients(bmi\>35) * patients with glaucoma (increased iop\>20mmgh) * patients with history of hypersensitivity to study drugs
rigorous evaluation of yes and know, a fully virtual sexual health and well-being intervention for youth

Conditions: Pregnancy Related; Sexually Transmitted Diseases; Adolescent Behavior

Summary: this study is a 2-arm cluster randomized controlled trial with approximately 1,200 youth aged 14-19 years to assess the effectiveness of yes and know, a sexual health education program. to be eligible, participants must be 14-19 years old and english-speaking. those in the treatment arm will receive yes and know, a synchronous virtual program delivered over multiple sessions totaling nine hours, along with asynchronous online activities and resources. those in the control arm will receive a similarly structured program focused on nutrition education. participants will complete brief online surveys at baseline and at 3 and 12 months after the synchronous sessions. the study will assess the program's effectiveness in reducing the prevalence of unprotected sex among youth and improving short-term outcomes, such as knowledge of reproductive health and healthy relationships, self-efficacy, and the use of reproductive health services.

for the yes and know study, cohorts of 5-15 participants will be recruited and randomized into one of the two study conditions: yes and know: life skills intervention (intervention condition) or yes and know: nutrition skills intervention (comparison condition). the programs will be delivered by trained health educators through synchronous virtual sessions. participants can access the supplemental resources and activities for their respective programs on the program's website. each cohort will be recruited from a local partner site (with a focus on rural communities in the south and southeast regions of the united states), and young people must have consent and provide their assent to be part of the study. yes and know: sexual health and life skills covers sexual and reproductive health, healthy relationships, life skills, and educational and career success. yes and know: nutrition skills covers learning to make healthy decisions about food, weight and disordered eating, and creating nourishing meals. both programs consist of nine 60-minute synchronous group sessions, totaling nine hours, to be taught at least once a week (or more frequently depending on sites' scheduling).

Eligibility criteria:
inclusion criteria: * ages 14-19; and * english speaking. exclusion criteria: - anyone not meeting inclusion criteria.