Kornimate/medical-research-clean huggingface dataset:
non invasive ventilation versus continuous positive airway pressure after extubation of very low birth weight infants.

Conditions: Neonatal Respiratory Failure

Summary: the purpose of this study is to determine whether nasal intermittent positive pressure ventilation (nippv) non synchronized is better than continuous positive airway pressure (ncpap)in preventing extubation failure within 72 h, after extubation of very low birth weight infants at the neocosur network.

is a randomized trial to preterms infants \<1500g and less than 34 weeks with rds requiring machanical ventilation in the extubation period, randomized to receive nippv or ncpap once extubation criteria were met. parental written informed consent is required previous extubation. the failure rate is defined as the need for re-intubation and mechanical ventilation). exclusion criteria are: major congenital anomalies; presence of cardiovascular instability;intubation less than 2 hours; mechanical ventilation more than 14 days, using muscle relaxant, airway anomalies, consent not provided or refused. outcome measures: the primary outcome was to assess the need for re-intubation within the first 72 hours after extubation in the 2 groups. the criteria for failure were met by at least 1 of the following: ph \ 65 mmhg; recurrent apnea more than 2 episodes per hour associated with bradycardia; during 4 hour continuous; 2 episodes of apnea that required bagand-mask ventilation in any time during the study; or a pao2 \ 0.6. the secondary outcomes concerning respiratory support were total duration on ett ventilation, total duration on ncpap, total duration on supplemental oxygen, incidence of pneumothorax,bpd and dead. other outcomes included incidence of patent ductus arteriosus (pda), necrotizing enterocolitis, intraventricular hemorrhage grades 3 and 4, retinopathy of prematurity stage 3, time to full feeds, and length of hospital stay. sample size calculations for the primary outcome: we estimated that there would be a more than 80% chance of detecting 43% difference between the groups (alpha 0.05) when samplesize (n) is 110 patients for each mode of treatment.

Eligibility criteria:
inclusion criteria: * preterm with a weight less than 1501 g * gestational age less or equal to 34 weeks * preterm that meets extubation criteria after at least 2 hours and less than 14 days connected to mechanical ventilation * patient receiving methylxanthynes exclusion criteria: * patient more than 14 days in mechanical ventilation * newborn with congenital cardiopathy * newborn with congenital malformation * newborn wirh chromosomopathy or genopathic disease * newborn with suspected gastrointestinal disease * newborn with neuromuscular disease or receiving muscle relaxants * lack or informed consent signed by parents or legal representative
a study to assess multidomain endpoints of an ecg patch

Conditions: Acute Decompensated Heart Failure

Summary: this study aims to evaluate the utility of a wearable heart monitoring patch that can be worn on the body to collect various measurements related to heart failure and develop a concept to potentially be used as a new measurement. it is crucial to test out new ways that make it easier to do research for new drugs and increase our chances of knowing how well they will work early on in the development process. results from this study will be useful in planning future development programs for drugs aimed at treating patients with heart disease. this study will be conducted in a single hospital, it is non-randomised (not chosen by chance), exploratory, study in the united kingdom (university hospitals of leicester nhs trust). it aims to involve up to 80 men and women recently admitted due to sudden, severe heart failure symptoms. participants will be part of the study for about two months, with one hospital visit after discharge, as commonly done in heart failure centres. * visit 1 (pre-screening/screening/enrolment) will assess the participant's eligibility for participating in the study and for collecting data following hospitalisation for acute decompensated heart failure (adhf). participants will be trained and receive an ecg patch to wear from that moment onwards at home for a period of 4 to 7 days. * visit 2 (follow-up visit) will be conducted approximately 6-8 weeks post visit 1 and this will be the final study-related site visit. participants will receive an ecg patch to wear at home for a second time for a period of 4 to 7 days. * visit 3 (review of medical records). it is a review of the health status using medical records by the study team. the participant is not expected to attend the hospital for any appointments


Eligibility criteria:
inclusion criteria: * men and women aged 18 years or older * confirmed diagnosis of heart failure according to the latest esc criteria * primary cause of hospitalisation due to decompensated heart failure * willing and able to complete all visits and assessments as per protocol * provision of signed and dated, written informed consent before any study-specific procedures. exclusion criteria: * receiving renal replacement therapy * implanted cardiac (or other) device in-situ, cardiac pacemaker, defibrillator, or other implanted electronic devices or other ventricular assist device in situ * currently receiving chemotherapy * receiving end-of-life care * active severe infection: individuals with an active severe infection, as determined by the pi's clinical judgment, will not be eligible for study participation * hypersensitivity to patch adhesive/ materials in the patch * skin condition or damage that prevents wearing of the patch.

Keywords: acute decompensated heart failure; heart failure; ecg patch
efficacy of tecar device with exercises in ankle sprain

Conditions: Ankle Sprain; TECAR Therapy; TECAR Therapy Efficacy in the Treatment of Ankle Sprain; Ankle Dynamic Balance; Ankle Pain; Ankle Proprioception

Summary: the goal of this clinical trial is to evaluate the effect of applying tecar therapy during active therapeutic exercises on pain, ankle dynamic balance, proprioception, and daily function in patients with acute ankle sprain. the main questions it aims to answer are: * does there is a significant effect of applying tecar therapy during active exercise after acute lateral ankle sprain on pain? * does there is a significant effect of applying tecar therapy during active exercise after acute lateral ankle sprain on balance? * does there is a significant effect of applying tecar therapy during active exercise after acute lateral ankle sprain on proprioception? * does there is a significant effect of applying tecar therapy during active exercise after acute lateral ankle sprain on daily function? the patients will be randomly divided into two groups. the control group (a) will receive the conventional therapy which is ankle and subtalar rom in a pain-free range, calf muscle stretch, ankle strengthening exercises against resistance bands in all directions, weight-bearing exercise, forward lunges, bilateral and unilateral squats, bilateral and unilateral heel raises against bodyweight resistance, and balance training. the experiment group (b) will receive conventional therapy with tecar therapy application during active therapeutic exercises. treatment will be for 4 weeks with 2 sessions per week. tecar application will be 20 mins per session (10 mins capacitive and 10 mins resistive). to the best of the researchers' knowledge, no study has proved the effects of applying tecar therapy during active therapeutic exercises after an acute lateral ankle sprain has yet been done. thus, the purpose of the present study was to prove if there an effect of applying tecar therapy during active therapeutic exercises included in the conventional physiotherapy (price with therapeutic exercises) and conventional physiotherapy alone on pain, ankle dynamic balance, proprioception, and daily function in subjects with an acute lateral ankle sprain.


Eligibility criteria:
inclusion criteria: * gender will be male and female. * age from 20-40 years old. * grade \| and \|\| lateral ankle sprain. * patients who will be diagnosed and referred by orthopedic surgeon. * acute stage of lateral ankle sprain. * bmi ≤ 30. * positive confirming tests. exclusion criteria: * ankle fractures such as talus bone fracture, tibia fracture, ankle dislocation. * unwilling to continue treatment. * contraindications to use tecar therapy, such as pregnancy, the presence of malignant tissue, tumors, in the ankle, and electrical devices implanted in the body. * grade \|\|\| ankle sprain. * systematic diseases such as rheumatoid arthritis. * recently received intra-steroid injection * pain exacerbation during the intervention.

Keywords: ankle pain ankle dynamic balance ankle proprioception ankle daily function tecartherapy
influence of tdcs on cortical plasticity in patients with mild cognitive impairment (mci)

Conditions: Patients With Mild Cognitive Impairment

Summary: the aim of this study is to investigate whether the anodal transcranial direct current stimulation (tdcs) over the primary motor cortex (m1) in patients with mild cognitive impairment (mci) leads to an increase in cortical plasticity (change in motor evoked potentials (mep) in mv).


Eligibility criteria:
inclusion criteria: * right-handed according to the oldfield händigkeits inventory (lateralization index\> 70) (1971) * cognitive impairment according to the diagnostic criteria of a mci (amnesic or even multiple domains) * no therapeutic treatment with ache inhibitors * no motor impairments relevant to everyday life * age 50 to 80 years exclusion criteria: * severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected * epilepsy, epileptic seizure in medical history * cognitive deficit (mmse \<20) * depressive episode (beck depression inventory (bdi)\> 12) * newly taking (\<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors * pregnancy * pacemaker (contraindication for mri) * other metal parts in the body (contraindication for mri)

Keywords: mild cognitive impairment transcranial direct current stimulation cortical plasticity
fixation of the posterior malleolus in medium-sized trimalleolar ao weber-b fractures.

Conditions: Trimalleolar Fracture; Posterior Malleolus; Open Reduction and Internal Fixation

Summary: the optimal treatment of ankle fractures with involvement of the posterior malleolus remains a subject of debate. despite a large amount of literature on the role of the posterior malleolus in a so-called trimalleolar fracture, there are no clear guidelines for its treatment. its size is the leading indication whether fixation of the fragment is necessary or not. most orthopedic surgeons consider a posterior malleolar fracture fragment larger than 25% to 33% an indication for fixation. interestingly, after careful evaluation of the available literature, there does not seem to be hard evidence for these numbers. it is generally accepted that restoration of a normal anatomic mortise and normal tibiotalar contact area are key elements for a good functional outcome. inadequate reduction of the posterior fragment may alter the tibiotalar contact area and the joint biomechanics with altered stresses in parts of the joint, leading to the development of osteoarthritis and worse functional outcome. traditionally, reduction of these larger fragments is indirectly, followed by percutaneous screw fixation in anterior-posterior direction. disadvantages are that it is hard to achieve an anatomical reduction, and that fixation of smaller fragments is very difficult. recently, a direct exposure of the posterior tibia via a posterolateral approach in prone position, followed by open reduction and fixation with screws in posterior-anterior direction or antiglide plate is advocated by several authors. this approach allows perfect visualization of the fracture, articular anatomical reduction, and strong fixation. another advantage is that even small posterior fragments can be addressed. several case series are published, which describe minimal major wound complications, good functional outcomes, and minimal need for reoperation. since 2 years, in our institution we perform an open, anatomical reduction and fixation of all medium-sized posterior fragments via this approach. although not thoroughly investigated yet, it seems to lead to better clinical outcomes than described in the literature and our retrospective cohort study.


Eligibility criteria:
inclusion criteria: * age between 18 and 70 years old * first ankle fracture of the affected side. * trimalleolar ao-weber b fracture with additional medium-sized posterior fragment (5-25% of involved articular surface, ao type 44-b3) exclusion criteria: * severe traumatized patients * multiple fractures during visit emergency department * ankle fracture of the same ankle in the history * patients with pre-existent mobility problems * pre-existent disability * patients living in another region and follow-up will take place in another hospital. * inability to speak the dutch language.
nutritional status of pregnant women following bariatric surgery

Conditions: Obesity and Obesity-related Medical Conditions; Pregnancy; Metabolic Surgery

Summary: the aim of this observational study is to learn more about nutrient status during pregnancy after bariatric surgery. all pregnant women older than 18 years who underwent bariatric surgery and sought obstetric care within one of the participating hospitals were included and followed up until 2 months post-partum.


Eligibility criteria:
inclusion criteria: * older than 18 years * medical history of metabolic bariatric surgery (roux-en-y gastric bypass or sleeve gastrectomy) exclusion criteria: * elective termination of pregnancy * multiple pregnancy * metabolic bariatric procedures other than roux-en-y gastric bypass or sleeve gastrectomy * reversal of the bariatric procedure * malnutrition due to other causes (e.g., malignancy, alcoholism)

Keywords: nutrient status nutritional supplementation metabolic bariatric surgery
a multicenter clinical study on the continuous vs. intermittent infusion of ceftazidime-avibactam in critically ill patients with severe infections

Conditions: Patients With Critically Ill Infections

Summary: the objective of this study is to determine whether continuous infusion of ceftazidime-avibactam (caz-avi) could improve clinical outcomes in critically ill patients compared with intermittent infusion.

this study employs a prospective, open-label, randomized controlled, multicenter clinical trial design comparing "caz-avi continuous infusion" versus "caz-avi intermittent infusion," .the secondary objectives is to observe the clinical cure, bacterial clearance, the probability of target attainment (pta) of tdm. etc

Eligibility criteria:
inclusion criteria: * 18-85 years old, male or female. * patients who are admitted to icu wards. * patients clinically diagnosed with carbapenem-resistant organism (cro) infections, and has been commenced on targeted therapy with ceftazidime-avibactam. * one or more organ dysfunction criteria in the previous 24 hours i. map \ 4 hours; iii. respiratory support using supplemental high flow nasal prongs, continuous positive airway pressure, bilevel positive airway pressure or invasive mechanical ventilation for at least 1 hour. iv. serum creatinine concentration \> 220 μmol/l or \>2.49 mg/dl exclusion criteria: * patient has a known allergy to ceftazidime-avibactam. * patient has received ceftazidime-avibactam for more than 48 hours during current infectious episode. * patient is in severe condition or expected to survive for no more than 48 hours. * patient who receives lung or heart transplant or stem cell transplant. * patient is known or suspected to be pregnant. * patient has previously been enrolled in the current study. * other conditions which are regarded as inappropriate for enrollment.

Keywords: ceftazidime-avibactam continuous versus intermittent infusion clinical study
yoga intervention for the improvement of cancer-related stress in cancer survivors

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial develops and test a yoga intervention in improving cancer-related stress in cancer survivors. the online hatha yoga intervention of breathing and movement incorporates both restorative poses, breathing techniques, guided meditation and may reduce stress levels and improve overall quality of health in cancer survivors.

primary objective: i. to develop and test the feasibility of a standardized 12-week online hatha yoga intervention (n=30) of breathing and movement incorporating both restorative poses, breathing techniques, guided meditation. secondary objectives: i. to evaluate the yoga intervention in relation to self-reported levels of stress and quality of life in cancer survivors (n=30). ii. feasibility of collecting blood and saliva at baseline and post-intervention for stress biomarkers, including cortisol and norepinephrine. exploratory objective: i. to determine how behavior change, quality of life (qol), and biomarkers of adrenergic stress, inflammation, and immunosuppression are affected by a 12-week online yoga program completed by cancer survivors. outline: patients receive online yoga intervention once a week (qw) for 12 weeks. after completion of study, patients are followed up at 3 months.

Eligibility criteria:
inclusion criteria: * age \>= 18 years of age * have been diagnosed with a cancer and have finished treatment * have been cleared for physical activity by a physician or nurse practitioner (physician or nurse practitioner name and date clearance received) * participant must understand the investigational nature of this study and sign an independent ethics committee/institutional review board approved written informed consent form prior to receiving any study related procedure exclusion criteria: * unwilling or unable to complete the assessment in english * are pregnant or nursing * are unwilling or unable to follow protocol requirements * have skeletal instabilities and/or cardio-pulmonary comorbidities * have any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study
investigation of glass carbomer performance

Conditions: Dental Caries

Summary: the aim of this in vivo study was to evaluate the clinical 1 year follow-up of silica and flouroapatite reinforced glass carbomer filling material.

the aim of this in vivo study was to evaluate the clinical 1 year follow-up of silica and flouroapatite reinforced glass carbomer filling material. in this study, total of 100 (46 class i, 54 class ii) restorations were performed in 36 patients. all cavities were prepared conventionally. half of the restorations were restored with nano composite resin (tokuyama estelite, tokuyama dental, japan) and the other half were restored with glass carbomer material (gcp dental, the netherlands). rubber-dam was used for isolation. before the replacement of composite restorations, enamel edges were etched according to selective etching method. then universal adhesive system was applied. composite resin was applied to the cavity in 2 mm layers by incramental technique. glass carbomer was placed with bulk technique by applying finger pressure with surface covering. composite restorations were polymerized with led light curing unit. glass carbomer restorations were cured its own special curing unit. restorations were evaluated with modified usphs criteria at the end of the first week, 6 months and 12 months. data were analyzed using fisher's exact chi-square test, fisher freeman halton test and continuity (yates) correction. wilcoxon sign test was used for intra-group comparisons of the parameters. statistically significance was evaluated at p \<0.05.

Eligibility criteria:
inclusion criteria: 1. 20-25 years of age 2. no systemic diseases 3. presence of molar / premolar teeth with occlusal and / or interface caries 4. lack of parafunctional habits such as clenching and grinding of teeth 5. lack of cooperation problems 6. accepted regular visits - exclusion criteria: * 1-any endodontic treatment or withdrawal indications (abscess, swelling and fistula complaints, palpation and percussion pain, spontaneous or night pain) 2- teeth with congenital developmental defect 3- teeth with pathological mobility 4- teeth which do not have normal occlusion due to skeletal or pathological reasons 5- lack of contact or opposite teeth

Keywords: glass ionomer, composite, clinical
effect of mobile communication on congenital ectopia lentis follow-up adherence

Conditions: Ectopia Lentis

Summary: regular follow-up is essential to successful management of congenital ectopia lentis, but it is often ignored by parents in china. with rapid economic development, there are increasing numbers of mobile phone users that allow for communication applications to be used in medical care. the investigators aimed to assess the potential of the smartphone application assisted medical service to increase patient compliance in attendance of follow-up after congenital ectopia lentis treatment.

congenital ectopia lentis is a rare ophthalmic disease that seriously harms the physical and mental health of patients. surgery is the only definite treatment at present. however, severe visual impairment is common in congenital ectopia lentis patients in china, and delayed presentation to hospital and late surgical treatment are found to be the major reasons. in china, the messaging application wechat has become the most popular communication tool. as most congenital ectopia lentis patients' parents are younger people, they are more likely to use technology, such as wechat, in their daily lives. in addition, it allows ophthalmologists to utilize this communication application to relay health related information and reminders to patients. this makes it feasible to apply this smartphone application in improving attendance of follow-up visits. in this trial, the investigators aimed to assess the potential of the smartphone application assisted medical service to increase patient compliance in attendance of follow-up after congenital ectopia lentis treatment.

Eligibility criteria:
inclusion criteria: * 1. identified with congenital lens dislocation after surgery and age ≤ 18 years old; 2. parents were able to access a mobile phone and communicate via the smartphone application (wechat); 3. agree to participate in this study and sign the informed consent. exclusion criteria: * 1. with other ophthalmic diseases such as glaucoma, uveitis and corneal disease.