Kornimate/medical-research-clean huggingface dataset:
protective variable ventilation for open abdominal surgery

Conditions: Development of Pulmonary Dysfunction Following Open Abdominal Surgery

Summary: variable ventilation has been shown to improve lung function and reduce lung damage as well as inflammation in different models of the acute respiratory distress syndrome. also, variable ventilation is able to recruit lungs. the present study will investigate whether variable as compared to non-variable ventilation improves post-operative lung function and reduces systemic inflammation in patients submitted to open abdominal surgery.


Eligibility criteria:
inclusion criteria: * elective open abdominal surgery * asa classification 2-3 * age between 18 und 85 yrs * expected duration of surgery \> 3 h * expected extubation in the operation room * written informed consent exclusion criteria: * chronic lung disease (except to copd stadium i and ii, and asthma) * body mass index (bmi) \> 40 * allergy to one of the drugs to be used for general anesthesia * participation in another interventional trial within 4 weeks before enrollment * addiction or any other disease that may interfere with the capacity of giving informed consent * pregnant or breastfeeding women * women in reproductive age, except to those who fulfill one of the following: * post-menopause (12 months natural amenorrhoea, or 6 months amenorrhoea and serum fsh \> 40 mlu/ml * post-operative (6 weeks after two-sided ovariectomy) * routine and correct use of anticonceptional methods with failure rate \< 1 % per year * sexually not active * vasectomy of the partner * indication of low compliance with the protocol * contraindication for mri examination

Keywords: mechanical ventilation lung function abdominal surgery, open systemic inflammation
effects of dietary polyphenols and ω-3 fatty acids on cardiovascular risk factors in high risk subjects

Conditions: Metabolic Syndrome

Summary: the aim of this study is to explore if a 8-weeks dietary intervention with polyphenols and omega 3 fatty acids (alone or combined) may be effective on postprandial lipids metabolism and other cardiovascular risk factors in people at high cardiovascular risk.

fish consumption is associated with a lower cardiovascular risk and dietary supplementation with ω-3 fatty acids reduces plasma triglyceride levels. the mechanisms of action of ω-3 fatty acids are currently not completely understood. it has been hypothesized that polyunsaturated ω-3 fatty acids beneficial effects may be mediated through their ability to facilitate plasmalogen replenishment. polyphenols are associated with beneficial effects on some cardiovascular risk factors, in particular with a reduced lipid oxidation. less data are available on their effects on lipid metabolism. recent data suggest that these effects could be mediated by changes in plasmalogen levels. the effects on lipid metabolism of combining the two dietary approaches (ω-3 fatty acids and polyphenols) are not known. while developed populations live for the most part in the postprandial state, much of the information on lipid metabolism refers to fasting condition. dietary intervention study design eighty people at high cardiovascular risk randomly assigned to one of the four different nutritional 8-week interventions: (a) control diet poor in omega-3 fatty acids and polyphenols (b) diet rich in omega-3 fatty acids (c) diet rich in polyphenols (d) diet rich in omega-3 fatty acids and polyphenols

Eligibility criteria:
inclusion criteria: * bmi \>25\<35 kg/m2 * high waist circumference (men \>102 cm, women \>88 cm) + one the following components of metabolic syndrome : fasting plasma triglycerides ≥150 mg/dl fasting hdl-col \<40 mg/dl (men) and \<50 mg/dl (women) fasting plasma glucose 100-125 mg/dl exclusion criteria: * fasting plasma triglycerides ≥400 mg/dl and cholesterol \>270 mg/dl * cardiovascular events (ami and/or stroke) in the last 6 months * diabetes mellitus * regular intensive physical activity * kidney (serum creatinine \>1.7 mg/dl) and liver (transaminases \>double) * hypolipidemic or antinflammatory drugs * anemia (hb \<12 g/dl) or any other chronic disease

Keywords: polyphenols omega-3 postprandial lipemia adipose tissue
orthofeet: a prospective proof of concept trial to evaluate an innovative pain relief footwear

Conditions: Foot Pain

Summary: the purpose of this prospective randomized crossover study is to evaluate the effectiveness of a new pain relief footwear, orthofeet, in reducing foot pain and improving daily physical activity. the investigators hypothesize that wearing orthofeet shoes will lead to a reduction in foot pain, resulting in increased daily physical activity, objectively measured using validated wearable devices.

a clinical study at baylor college of medicine is being conducted to evaluate the short- and intermediate-term benefits and effectiveness of a novel pain relief footwear, orthofeet. this 12-week randomized crossover trial aims to recruit 50 eligible ambulatory adults (aged 50 years or older) with moderate self-reported foot pain. participants will be randomly assigned to group ab (25 subjects) or group ba (25 subjects), with no differences in assessments or eligibility criteria between the groups. in group ab, participants will wear orthofeet shoes for 6 weeks, followed by their own shoes for another 6 weeks, while group ba will follow the reverse order. pain and function, the primary outcomes, will be measured using the foot function index (ffi), and acceptability will be assessed using a technology acceptance model (tam) questionnaire. data will be collected at baseline, 6 weeks, and 12 weeks.

Eligibility criteria:
inclusion criteria: * 50 years or older * self reported foot pain including heel, arch, or ball of foot exclusion criteria: * plantar ulcer patients with major foot deformity (e.g., charcot foot, pes cavus) * lower extremity amputation including minor amputation. foot pain because of nail disorder or keratotic lesions (e.g. corns, calluses) * unstable conditions such as recent stroke, anticipated changes in medication regime * acute fractures of the foot * non-ambulatory or unable to stand without help or walk a distance of at least 6 feet without assistance. * major cognitive impairment or major depression

Keywords: foot pain falls frailty footwear mobility
intravenous immunoglobulin (ivig) in lung transplantation

Conditions: Hypogammaglobulinemia; Lung Transplantation

Summary: the purpose of this study is to determine if intravenous immunoglobulin (ivig) can prevent bacterial infections in lung transplant patients with low serum levels of immunoglobulin.

an increased risk of infection despite intensive antimicrobial prophylaxis is a well-recognized complication of lung transplantation. recent evidence suggests that immunosuppressive therapy after solid organ transplantation may lead to humoral immunodeficiency due to hypogammaglobulinemia (hgg). in lung transplant recipients with hgg, ivig therapy offers the potential to significantly decrease the incidence and severity of infections, thereby reducing morbidity and potentially mortality. comparison: the investigators are conducting a randomized clinical trial of ivig versus placebo for lung transplant patients with severe hgg to see if ivig decreases the number of bacterial infections in these patients.

Eligibility criteria:
inclusion criteria: * lung transplant recipients \> 3 months after transplant surgery * immunoglobulin g (igg) \< 500 mg/dl * stable medical regimen exclusion criteria: * acute rejection * active infection * contraindication to ivig * pregnancy * recent thrombotic event

Keywords: hypogammaglobulinemia lung transplantation
laac-registry: clinical outcome after echocardiography-guided laa-closure

Conditions: Atrial Fibrillation; Cardiovascular Diseases; Thromboembolism

Summary: the study aims at comparing, in a large cohort of consecutive clinically indicated left atrial appendage closure, clinical and imaging outcomes between different subpopulations.

percutaneous left atrial appendage closure (laac) has established itself in clinical practice as a safe and efficient therapeutic option for atrial fibrillation patients with a relative/absolute contraindication to oral anticoagulation. the purpose of this observational study is to prospectively collect procedural and follow-up data of all patients submitted to a clinically indicate laac in order to assess the impact of patient characteristics, procedural technique (imaging used to guide/plan procedure, device implanted, post-procedural drug regimens, etc.) on procedural safety and efficacy. the endpoints will be assessed by means of clinical follow-up at 1-3-5 years after laac and imaging exams (tee at1-3 months, ccta at 1-13months).

Eligibility criteria:
inclusion criteria: * age\> 18 * written informed consent to participate in the study * patients with paroxysmal, persistent, or permanent non-valvular af and cha2ds2-vasc score of ≥2 that are planned for an elective laa-closure * anatomic characteristics allow placement of a ce marked device, dedicated for laac exclusion criteria: * none. considering the nature of the project, which is to prospectively collect information on all patients treated with laac in our center, we will only exclude patients unwilling to sign the informed consent.

Keywords: left atrial appendage closure amulet watchman watchman flx acp cardiac computed tomography angiography transesophageal echocardiography peridevice leak thromboembolic events atrial fibrillation
treatment of patients with anxiety disorder (0777-022)

Conditions: Generalized Anxiety Disorder

Summary: the purpose of the study is to examine the safety and efficacy of mk0777 during treatment for generalized anxiety disorder.


Eligibility criteria:
inclusion criteria: * male and female patients ages 18 to 70 exclusion criteria: * women who are breastfeeding or pregnant * positive result at prestudy on urine drug screen for illicit drugs * history of alcohol or drug abuse
substrate guided ablation therapy for atrial fibrillation

Conditions: Persistent Atrial Fibrillation

Summary: atrial fibrillation (af), often referred to as an 'irregular heartbeat', is the most common abnormal heart rhythm worldwide. af may be intermittent (termed paroxysmal) or sustained (termed persistent).catheter ablation is increasingly being used to manage individuals with af, however in a significant proportion of cases af recurs. such rhythm control interventions are known to be less effective in individuals with persistent af compared with those with paroxysmal af. analysis of heart tissue of individuals with af show deposition of scar tissue within the heart muscle and this scar tissue promotes abnormal electrical activity that is involved in causing af. the aim of the proposed study is to evaluate the feasibility and effectiveness of combining conventional pulmonary vein isolation (pvi) during catheter ablation for af with adjunctive substrate ablation.

this is a single-centre, non-randomized study investigating the feasibility, safety and efficacy of substrate guided ablation in persistent af. the study population will be patients between the ages of 18 and 80 with symptomatic, persistent atrial fibrillation (≥1 year) referred for catheter ablation on standard clinical grounds. the catheter ablation procedure will be performed using the precision ensite™ three dimensional mapping system and the advisor high density grid™ mapping catheter (abbott medical incorporated). all patients will undergo conventional pulmonary vein isolation (pvi). as an adjunctive strategy to pvi, low voltage areas (used as a surrogate for atrial scar), as derived from the voltage map, will be targeted for ablation in order to isolate or homogenise these areas of the atrium. a pre-procedural cardiac magnetic resonance imaging scan will be performed in all patients. all patients will undergo 12 months follow-up with an ecg and ambulatory holter monitoring at 3, 6 and 12 months.

Eligibility criteria:
inclusion criteria: * patients aged ≥18 years and ≤ 80 with a clinical indication for persistent atrial fibrillation ablation exclusion criteria: * contraindication to anticoagulation * thrombus in the left atrium despite anticoagulation * cerebrovascular accident within the previous 6 months * patients actively participating in another research study will be not be permitted to enrol. patients who have been involved with other research studies will be able to participate after a minimum period of 3 months after completion of prior study follow up * females of childbearing potential must have a negative pregnancy test on the day of the ablation procedure due to the radiation exposure during the procedure

Keywords: atrial fibrillation catheter ablation substrate
emg-based hand-wrist control: study b mirrored

Conditions: Amputation; Amputation; Traumatic, Hand; Amputation, Congenital; Prosthesis User

Summary: study assessing four-channel prosthesis controller, that compares contralateral (mirrored) emg-force training to ipsilateral emg-target training with both limb-absent and able-bodied subjects

system identification models relating forearm electromyogram (emg) signals to phantom wrist radial-ulnar deviation force, pronation-supination moment and/or hand open-close force (emg-force) are hampered by lack of supervised force/moment output signals in limb-absent subjects. in able-bodied and unilateral transradial limb-absent subjects, we studied three alternative supervised output sources in one degree of freedom (dof) and 2-dof target tracking tasks: (1) bilateral tracking with force feedback from the contralateral side (non-dominant for able-bodied/ sound for limb-absent subjects) with the contralateral force as the output, (2) bilateral tracking with force feedback from the contralateral side with the target as the output, and (3) dominant/limb-absent side unilateral target tracking without feedback and the target used as the output.

Eligibility criteria:
inclusion criteria: * limb-absent subjects: unilateral trans-radial limb absence or amputation * be capable of completing the requested contractions on the affected dominant side exclusion criteria: * past injuries to the upper limbs that would limit their ability to complete the requested contractions * scars that would impede the use of surface electrodes

Keywords: prosthesis electromyography emg semg control myo regression transradial terminal device electrodes
evaluation of pain following scoliosis surgery.

Conditions: Idiopathic Scoliosis

Summary: the main objective of this study was to evaluate acute pain following scoliosis surgery in adolescent.


Eligibility criteria:
inclusion criteria: * adolescent from 10 to 18 years of age * idiopathic scoliosis * posterior surgery for spinal arthrodesis * non opposition children and parents exclusion criteria: * complication following surgery needing reoperation * secondary intervention * anterior surgery * non idiopathic scoliosis
electromyographic estimation of neuro-muscular coordination of masticatory muscles in patients treated with implants (d-2012-057)

Conditions: Edentulous; Teeth Replacement; Bounded Edentulous Space

Summary: the result of the study will demonstrate that the functional activity of maxillofacial area with edentulous posterior bounded spaces recovers more effectively in patients treated with restorations on implants comparing to patients treated with fixed dentures.

all patients will be provided with electromyographic research before denture treatment, in a month and three months after the termination of treatment.

Eligibility criteria:
inclusion criteria: * partially edentulous bounded space in dental arch (not more that 3 teeth absent) * patients ages 20-45 y.o. exclusion criteria: * chronical third-degree cardiac failure * connective tissue diseases * decompensated diabetes * neoplastic processes * strokes
comparison of topical 5%potassium hydroxide vs liquid nitrogen in the treatment of plane warts

Conditions: Plan Warts

Summary: abstract objective: to study the efficacy while comparing potassium hydroxide 5% with liquid nitrogen in treatment of plane warts. study design: randomized-controlled trial (rct), (double-blind). study setting and duration: dept dermatology, cmh-abbottabad, nov-2022 / april-2023. methodology: the sample size of 60 patients (children and adults aged 4 to 30 years) was calculated using openepi app sample size rct calculator, after informed consent by using non-probability consecutive sampling technique. patients randomly assigned into two groups i.e. in group-a 30 patients were given topical 5%-potassium hydroxide solution on affected area once at night upto 4 weeks and in group-b 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. patients were reassessed at every two weeks and final assessment was done at 12th week whereas followed up for 3 months to monitor recurrence. demographic information and frequency percentages were calculated for qualitative variables by using spss26. to determine statistical significance taking p-value \<0.05 as significant, and χ2-square test was used.


Eligibility criteria:
inclusion criteria: * age 4-30 years * both males and females * greater than 3 number of warts exclusion criteria: * pregnancy * breast feeding * those who are taking immunosupressive drugs
supporting treatment adherence needs in diabetes

Conditions: Type 1 Diabetes

Summary: there is an unmet treatment need for depressed adolescents with type 1 diabetes. to address this unmet need, we have designed a new, family-based, cognitive-behavioral intervention to reduce depressive symptoms, improve family functioning, and improve medication compliance. the intervention is delivered in two phases (1 - reduction of depressive symptoms and family conflict, 2 - adherence promotion) as efforts to improve adherence will have a greater likelihood of success if individual and family functioning variables are addressed first. to test the effectiveness of this intervention in reducing depressive symptoms and improving adherence, we will conduct a randomized controlled trial comparing this new intervention to usual care in a sample of fifty-two adolescents with type 1 diabetes and their primary caregivers. given the absence of this type of intervention and the significance of the problem, this study is timely and important, as it has the potential to positively impact diabetes-specific health outcomes.


Eligibility criteria:
inclusion criteria: * age 13-17 * diagnosis of type 1 diabetes according to criteria from the ada for at least 1 year * daily insulin dosing of at least 0.5 units per kilogram per day * clinical elevation on the cdi (i.e., score at or above 13) * assent to participation in study exclusion criteria: * other chronic, physical disease or condition except for celiac or thyroid disease * diagnosis of major mental disorder (e.g., bipolar disorder, thought disorder, anorexia nervosa) * diagnosis of developmental disorder (e.g., mental retardation, autism, asperger's) * current enrollment in psychotherapy specifically targeting depression

Keywords: adolescents depression adherence family functioning intervention
early administration of recombinant erythropoietin (rhepo) in transfusion savings in trauma patients

Conditions: Trauma

Summary: the objective of our study is to demonstrate the interest of early administration of recombinant erythropoietin in trauma patients

could an early use of rhuepo (recombinant human erythropoietin ) be lead to an individual benefice on transfusion savings after traumatic surgery?

Eligibility criteria:
inclusion criteria: * patients between 18 to 65 years old * patient with an asa 1 or 2 (asa 1 corresponding to a patient in perfect health and asa 2 to a patient with moderate involvement and well controlled organ function) * patient presenting at least one of the following fractures: basin and / or femur with surgical indication, associated or not with other fractures. * patient with hemoglobin between 9 and 13 g / dl at the time of admission on trauma department exclusion criteria: * patient with contraindication to synthetic erythropoietin * patient with intravenous iron contraindication * pregnant patient or with a risk of pregnancy * patient who has not given his consent or does not understand the protocol * patient with hemodynamic instability * patient participating in another research protocol for less than 3 months.
home neuromodulation of the neurogenic bladder in chronic spinal cord injury with transcutaneous tibial nerve stimulation

Conditions: Chronic Spinal Cord Injury; Neurogenic Bowel

Summary: determine the safety, feasibility, compliance, and efficacy of a daily home ttns protocol in chronic sci provided by self or caregiver for 4 weeks.

in specific aim 1, we will monitor for safety, feasibility, and compliance of a home ttns program for bladder management. in specific aim 2, the efficacy of home ttns will be compared to baseline incontinence- quality of life questionnaire. a bladder diary will also capture important information such as frequency and volume of catheterization, incontinence episodes, and other related observations.

Eligibility criteria:
inclusion criteria: * 18-65 years old * neurologically stable sci for ≥ 6 months * intermittent catheterization to empty bladder * stable bladder medications for ≥ 3 months exclusion criteria: * multiple medications for the bladder * other diagnoses to explain incontinence (ex: uti, bladder stones, multiple sclerosis, etc.) * 2+ pitting edema that does not resolve * known peripheral neuropathy or injury to the path of the tibial nerve * demand-type cardiac pacemaker or implanted defibrillator * cancer in the tibial nerve path and/or bladder * inability to elicit toe/plantar flexion with electric stimulation during the clinic visit. * inability to understand directions * non-english speaking

Keywords: electric stimulation
tools for wellbeing covid-19 national study of undergraduate students

Conditions: Stress; Anxiety; Depression; Resilience; Wellbeing; Mood

Summary: the study evaluates the effectiveness of yoga practices on reducing stress, negative emotion, anxiety, and depression and on increasing positive emotion, wellbeing and resilience. the study uses randomized wait-list control. all u.s. undergraduate students in 4-year universities and colleges age 18 or older are eligible to participate.

the purpose of this project is to widely disseminate a system of yoga tools to university students, faculty, and staff internationally to buffer the psychological impact of the covid-19 pandemic. a recent study finds that stress, anxiety, and depression are the major psychological responses to covid-19 during the early outbreaks in china (wang et al., 2020). globally, universities have closed campuses and moved learning, teaching, and working online with a very short notice. cdc suggests that keeping physically active and meditation are among the key activities to maintain a strong immune system and mental health during quarantine. studies have documented physical and mental benefits of yoga practices (balasubramaniam, telles, \& doraiswamy, 2013; brems, 2015; brunner, abramovitch, \& etherton, 2017; büssing, michalsen, telles, sherman, \& khalsa, 2012) this project introduces a system of yoga tools to buffer the psychological impact of covid-19. this system of yoga tools is designed by sadhguru jaggi vasudev, a yogi, mystic, author, and founder of the isha foundation. the isha foundation is a volunteer-based international non-profit organization, offering yoga and meditation programs for human wellbeing and global harmony. in partnership with the isha foundation and harvard university medical school, the study will document the short-term and long-term effects of these yogic practices on stress, mood, wellbeing, resilience, and academic engagement for students and work engagement for faculty and staff during this challenging time.

Eligibility criteria:
inclusion criteria: * 18 or older * enrolled in 4-year universities/colleges in 2020 * not graduate in may 2020 exclusion criteria: * younger than 18 * not enrolled in 4-year universities/colleges in 2020 * graduate in may 2020

Keywords: yoga stress anxiety depression wellbeing covid