Kornimate/medical-research-clean huggingface dataset:
using mobile application for rehabilitation in patients with chronic neck pain

Conditions: Neck Pain; Chronic Pain

Summary: the aim of this study is to reduce pain, increase range of motion, increase the endurance of deep cervical flexors muscles, and increase quality of life with mobile application in the treatment of patients with chronic neck pain. although many benefits of exercises have been proven, the effectiveness, follow-up and continuity of exercise will be investigated with mobile application tracking.

one of the important factors in mechanical chronic neck pain is the decrease in the endurance of the deep cervical flexor muscles. as a result of this decrease, an increase to the activation of m. scalenus anterior and m. sternocleidomastoid muscles is observed. it is known that patients avoid some movements due to pain, and as a result, loss of muscle strength and endurance in the neck, upper back, around the scapula and shoulder occurs. the loss in strength and endurance, combined with the severity of pain, may affect the stability of the upper extremity has been considered. patients with chronic neck pain may experience a number of problems due to the predisposition to accompany pain or some problems caused by neck pain. it is known that all these problems affect the quality of life of patients by limiting their daily living activities. with the developing technology, mobile health applications have started to be used more and more in our lives. in addition to preventing disease, reducing risk factors, increasing physical activity and quality of life, mobile applications are used in many different areas such as diagnosis, treatment, feedback and monitoring.

Eligibility criteria:
inclusion criteria: * having chronic neck pain in the past 6 months * no communication problem * be literate, * individuals who speaks turkish and can use developed mobile application exclusion criteria: * previous neck or shoulder surgery, * shoulder pain due to any reason, * having tumor or inflammatory disease underlying neck pain * having mental disorder, * individual with sequestered disc level or root compression, * individual with uncontrolled diabetes mellitus and hypertension * patients received additional treatment * patients who did not complete physical therapy sessions

Keywords: neck pain chronic pain mobile health mobile apps quality of life
basic mechanisms of meditation and cardiovascular disease in older blacks

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to evaluate the effects of meditation on older african americans with documented cardiovascular disease (cvd).

cardiovascular disease (cvd) is the leading cause of death and disability in older african americans, and accounts for 40% of the disproportionate risk for mortality observed in african americans compared to white americans. the majority of cvd patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. the pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and cvd. preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in african americans further suggests that these mechanisms are particularly relevant in this group.

Eligibility criteria:
inclusion criteria: * african-american (self-identified) * local residence * able to participate * coronary artery disease by mi, cabg, ptca (\>3 months prior), or angiography * consent and referring md approval

Keywords: cvd
impact of rapid flu testing in bmc ed

Conditions: Influenza-Like Illness; Influenza

Summary: the purpose of the study is to compare emergency department patients who undergo influenza testing using an fda-approved point-of-care device (cobas liat influenza a/b assay) located in the ed, to patients whose samples are sent to the bmc central laboratory. patients who agree to participate will have their samples randomly assigned to be tested on either at the core lab, or on the poc device. the current turnaround time for samples sent to the laboratory is approximately two hours; investigators expect that the point of care device can reduce this time. investigators will determine if the time to disposition and the administration of antibiotics is different in the group undergoing poc influenza testing compared to those undergoing laboratory-based influenza testing


Eligibility criteria:
inclusion criteria: * adult patients 21 years of age or older * presenting to the bmc main ed or urgent care area with influenza-like illness * physician ordered an influenza a/b diagnostic test exclusion criteria: * previously enrolled in the study * any influenza test result already available at the time approached by the ed ra * physician ordered comprehensive multiplex pcr respiratory pathogen assay instead of an initial influenza a/b-only test. * unable to give informed consent
pilot study of stem cell treatment of patients with vocal fold scarring

Conditions: Improved Healing of Scarred Vocal Folds; Improved Vocal Fold Status; Improved Vocal Fold Function

Summary: this is a pilot-study of 16 selected swedish patients which all have severe hoarseness or aphonia due to vocal fold scarring (from previous surgery, radiation therapy, inflammation or possibly hereditary). the patients are operated with phonomicrosurgical dissection of the scarred vocal folds, removal or scar tissue and injection of autologous mesenchymal stroma cells, amsc (which were previously harvested from each patients´s bone marrow, purified, expanded and characterized according to standard procedure at the center of hematology and regenerative medicine karolinska university hospital huddinge). 8 patients is planned to be treated with a single injection of amsc and 8 patients with injection of amsc mixed with a carrier hyaluronan gel developed at uppsala university sweden and at the karolinska institute. the laryngeal status, vocal fold function, and voice function will be followed individually with an advanced battery of examinations performed before and up to 1 year postoperatively. side effects and complications are noted and reported during surgery and following surgery at regular intervals during at least 1 year since spring 2015 no new patients have been recruited and no treatments are given during 2016 or 2017. the monitoring authority was changed from swedish national board of health to swedish medical product agency (mpa) in march/april 2016. further inclusions and treatments are postponed until permission is granted from mpa to continue the study.


Eligibility criteria:
inclusion criteria: * severe hoarseness * vocal fold scarring * no active other treatment * age above 18 years exclusion criteria: * active treatment of laryngeal disorder * active inflammatory condition of the larynx * diagnosed or suspicions of local malignancy

Keywords: vocal fold scarring mesenchymal stem cells
effectiveness of telepractice by smartphone app technology in preventing voice problems

Conditions: Prevention of Voice Disorders in Student Teachers

Summary: voice disorders in teachers have a significant impact on communication, quality of life, and economic costs to the healthcare system. we need to advance the prevention of voice disorders in teachers by testing an online telepractice model with synchronous (in real-time) and asynchronous (stored and accessed later) methods. the current study will investigate the effectiveness of the theoretically-driven global voice prevention model (gvpm) delivered by two methods; 1) online telepractice (synchronous and asynchronous) and 2) traditional, in-person for vocally healthy physical education and vocal music student teachers. effectiveness of the model will be assessed by voice-related measures captured daily on a smartphone app during student teaching, matching the asynchronous aspects of the telepractice model and representing the effects of vocal loading from teaching.


Eligibility criteria:
inclusion criteria: * senior at west chester university as of fall 2016 and fall 2017, * student teaching during spring 2017 or 2018, * healthy voice user, * owns a smartphone exclusion criteria: -
ultrasound guided quadratus lumborum block for postoperative pain in abdominoplasty

Conditions: Pain

Summary: the original concept of a quadratus lumborum block (qlb) indicated for analgesia after abdominal surgery was first described by blanco in 2007. also referred to as a posterior transversus abdominis plane (tap) block, the qlb consists in deposition of local anesthetic on either the posterior or the anterolateral border of the quadratus lumborum muscle. tap blocks have already been proved effective in urologic, abdominal, and gynecologic procedures by blocking the sensory nerve supply to the anterior abdominal wall thus reducing the amount of postoperative analgesic medication. the main advantages of qlb compared to the tap block is a wider sensory block area and a longer duration of analgesia. this is due to the extension of local anesthetic agents beyond the tap plane to the thoracic paravertebral space(4). previous reports have shown that qlb is effective in providing pain relief after various abdominal operations. however, there are no published reports on qlb for postoperative pain after abdominoplasty. this prospective, randomized, double-blinded, controlled study aims to evaluate the analgesic efficacy, opioids consumption and quality of recovery of qlb in patients undergoing abdominoplasty. patients scheduled to have abdominoplasty will be randomized to receive bilateral qlb with either ropivacaine 0.2% or normal saline. post-operative cumulative analgesic medication consumption, pain severity at rest and on movement, as well as quality of recovery will be evaluated and compared in both groups.


Eligibility criteria:
inclusion criteria: 1. standard abdominoplasty procedure 2. written informed consent 3. age ≥ 18 years 4. female exclusion criteria: 1. patient's refusal 2. allergies to any study medication 3. inability to comprehend or participate in scoring scales 4. deformations that could possibly affect the spread of the local anesthetic in the quadratus lumborum muscle plane 5. quadratus lumborum muscle plane not seen in ultrasound examination 6. coagulopathy or on anticoagulants

Keywords: qlb abdominoplasty quadratus lumborum block
hydros and hydros-ta joint therapy for pain associated with knee osteoarthritis

Conditions: Osteoarthritis of the Knee

Summary: the purpose of this study is to evaluate the safety and efficacy of hydros-ta joint therapy for relief of pain due to oa of the knee. hydros-ta is designed to provide fast acting and long lasting pain relief for up to six months with a single ia injection.


Eligibility criteria:
inclusion criteria: * have radiographic evidence within the prior 6 months, as shown in the radiology reports, of oa grade 2 or 3 using kellgren-lawrence grading for oa. * symptoms in the index knee for at least 12 months. * fully ambulatory subject (ability to perform a 15 meters walk test). * male and female subjects 40 through 85 years of age. exclusion criteria: * bmi \>40 kg * secondary oa (acute knee injury, rheumatoid arthritis, gout, history of joint infection, osteonecrosis, chronic fibromyalgia) or other chronic autoimmune disease. * intra articular steroid therapy in last 3 months * intra articular viscosupplementation in last 6 months

Keywords: osteoarthritis knee
dietary therapy in epilepsy treatment (diet-trial): a randomised non inferiority trial comparing kd, mad & lgit for drug resistant epilepsy

Conditions: Drug Resistant Epilepsy

Summary: this randomised trial is undertaken to assess whether mad or lgit is non-inferior to kd with regard to seizure control at twenty-four weeks among children with drug resistant epilepsy. the hypothesis of the study is that in 1 to 15-year-old children with drug resistant epilepsy, use of modified atkins diet (mad) or low glycemic index therapy (lgit) as an add on to the ongoing anti-epileptic drugs would not be inferior to ketogenic diet by \>15% in terms of seizure reduction from baseline seizure frequency at 24 weeks. the primary outcome of the study is to determine the efficacy of mad as compared to kd and lgit as compared to kd for seizure reduction in drug resistant epilepsy following 24 weeks of dietary therapy in 1 to 15-year-old children on anti-epileptic drugs. the change in seizure frequency will be estimated as percentage change in seizure reduction at 24 weeks as compared to baseline.


Eligibility criteria:
inclusion criteria: 1. children aged 1-15 years with drug resistant epilepsy (drug resistant epilepsy for the study will be defined as seizure frequency \>4 seizures per month, and treatment failure of ≥2 prescribed antiepileptic drugs). 2. willing to come for regular follow up exclusion criteria: 1. surgically remediable cause for drug resistant epilepsy 2. proven inborn error of metabolism except those in which kd is indicated (i.e., pyruvate carboxylase deficiency and glut-1 deficiency) 3. previously received kd, mad or lgit 4. known case of 1. chronic kidney disease 2. chronic liver disease/ gi illness 3. chronic heart disease (congenital and acquired) 4. chronic respiratory illness
cardinal- a clinical study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of tern-701 in participants with chronic myeloid leukemia

Conditions: Chronic Myeloid Leukemia, Chronic Phase; Chronic Myeloid Leukemia

Summary: the goal of the study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of tern-701, a novel highly selective allosteric inhibitor of bcr-abl1, in participants with previously treated chronic phase - chronic myeloid leukemia (cp-cml). the study has two parts: part 1 of the trial (dose escalation) will evaluate sequential dose escalation cohorts of tern-701 administered once daily. part 2 (dose expansion) consists of randomized, parallel dose expansion cohorts of tern-701 that will further evaluate the efficacy and safety of at least 2 recommended dose levels for expansion selected from part 1. in both part 1 and part 2, participants will receive continuous daily dosing of tern-701 divided into 28-day cycles. during the treatment period, participants will have scheduled visits to the trial center at cycle 1 day 1(c1d1), c1d2, c1d8, c1d15, and c1d16, followed by day 1 of cycles 2 through 7, and day 1 of every 3 cycles thereafter. approximately 100 participants could be enrolled in this trial, including up to 60 participants in part 1 (dose escalation), including optional backfill cohorts, and approximately 40 participants in part 2 (randomized dose expansion). all participants will receive active trial intervention. at least 4 dose-level cohorts may be evaluated in part 1; at least 2 dose levels may be evaluated in part 2.


Eligibility criteria:
key inclusion criteria: * male or female participants ≥ 18 years of age at the time of signing the informed consent * have an ecog performance status score of 0 to 2 * have an established cytopathologically confirmed diagnosis of bcr-abl1 positive cml in chronic phase * have received treatment with active site targeting tkis and have treatment failure, suboptimal response, or treatment intolerance * prior treatment with asciminib may be allowed * adequate organ function, as assessed by local laboratory key exclusion criteria: * systemic antineoplastic therapy (including prior tkis, interferon-alfa, therapeutic antibodies, chemotherapy) or other experimental therapy 7 days before the first dose of tern-701 * have completed previous anticancer therapy without resolution of all associated clinically significant toxicity (to ≤ grade 2 or baseline)

Keywords: allosteric inhibitor of bcr-abl1 cml tern-701 chronic myeloid leukemia t315i t315i mutant cardinal hs-10382
retrospective evaluation of infections after delivery

Conditions: Postpartum Infection

Summary: in general, transabdominal and transvaginal ultrasound represent the first imaging method in the study of suspected postpartum infections because of its good sensitivity, low cost, and high safety for patients (in fact, it allows the patient to be studied at the bedside, even in clinically unstable patients, it is well tolerated by patients, and it has no risks). ct has an excellent sensitivity in the diagnosis of postpartum infections, however, it has some drawbacks: it is not an examination that can be performed in clinically unstable patients, it cannot be performed at the patient's bedside, it has high costs, and it involves the administration of a significant dose of radiation . there are conflicting data in the literature regarding which examination is most useful for the diagnosis/management of infections in postpartum. therefore, the investigators want to evaluate whether ultrasound alone, compared with management with combined ultrasound and ct scan, is a useful and sufficient diagnostic tool for the diagnosis and management of postpartum infectious complications.

cases of infection recorded as a result of these parts will be reviewed. laboratory tests and clinical data of these will be reviewed. instrumental, ultrasound and ct images taken in the postpartum for diagnostic confirmation and subsequent follow-up will also be reviewed. for each patient, information will be collected on: * age, weight, height * previous pregnancies and their outcome * pregnancy that arose spontaneously or through medically assisted procreation techniques * conditions concomitant or complicating pregnancy * pregnancy outcome (spontaneous delivery or cesarean section) * laboratory tests * clinical data collected during hospitalization (vital parameters, symptoms, any medications administered) * radiologic (ct) or ultrasound (transabdominal and/or transvaginal) investigations performed during the hospital stay, in continuation-iter or in a subsequent hospitalization: name and model (and probe, for ultrasound examinations) of the equipment used will be specified for each examination performed.

Eligibility criteria:
inclusion criteria: * women aged 18 years or older * diagnosis of postpartum infection (within 30 days after delivery). clinical diagnosis is established by the following criteria (two or more of the following): * temperature \>38°c or \<36°c * hr \>100 bpm * fr \>20 respiratory acts/min or paco2 \<32mmhg * gb \>14 x 109/dl or \<4 x 109/dl * ega: lactates \>2mmol/l (or 18 mg/dl) * pcr \>2ds from normal value * procalcitonin \>2ds from normal value or positive laboratory culture result for the presence of bacteria (urinoculture, peritoneal fluid culture, abscess...). * obtaining informed consent * women who have had at least one ultrasound (transabdominal and/or transvaginal) and one ct scan for suspected postpartum infection exclusion criteria: * women with localized or systemic infection following infection unrelated to delivery or incision site (in case of cesarean section), such as pneumonia, mastitis, influenza, covid-19.

Keywords: ultrasound
systematic prevention of further fractures in patients with hip fractures and osteoporosis.

Conditions: Hip Fracture; Osteoporosis

Summary: the purpose of this study is to determine if prevention of further fractures is possible through systematic evaluation for osteoporosis in patients with recent hip fracture

osteoporosis is a common disease characterized by an increased risk of fracture. furthermore recent studies has revealed that patients with fractures have increased risk of renewed fracture. most fractures in the elderly are partly attributable to osteoporosis. the most severe of these shown to be the hip fracture (hfx) which increase mortality and decrease health related quality of life and has major impact on the level of national health service. solid evidence is available showing several interventions to reduce the risk of osteoporotic fractures. in spite of this only few hfx patients are offered examination or treatment for osteoporosis and very rare this happens on a routine basis. in the county of funen and ribe in denmark the departments of endocrinology and orthopedic surgery at odense university hospital and hospital of south western jutland therefore initiated a fracture discharge program as part of a health technology assessment (hta) study offering evaluation for osteoporosis to hfx patients. evaluation consists of duel energy x-ray absorptiometry, instant vertebral assessment, a biochemical panel, and clinical assessment followed by specific anti-osteoporotic treatment as appropriate. the hta study is designed as a longitudinal cohort study of patients admitted to the participating departments with a low energy hfx. inclusion started january first 2005 and ends december 31. 2006. after the last inclusion the follow up of the last patient are set to 2 years. in the study period data will be collected on subsequent fractures, epidemiological and demographic factors, questionnaires on quality of life, and register data on mortality, use of medication, and use of health services. the control group consists of patients admitted to any other hospital in the two participating counties who are not given this systematic evaluation for osteoporosis on a routine basis. the hta report will provide data to suggest if a systematic offer of evaluation and treatment of osteoporosis in hfx patients: can reduce further fractures is accepted by the majority of patients can increase the amount of life years by decreasing mortality can increase quality of life by reducing the amount of fractures is cost effective for the health care providers

Eligibility criteria:
inclusion criteria: * admitted to the department of orthopedic surgery at odense university hospital or hospital of south western jutland with a low energy hip fracture exclusion criteria: * dementia * pathological fracture * severe comorbidity * not wanting to participate

Keywords: prevention health technology assessment population based fracture