Kornimate/medical-research-clean huggingface dataset:
nasal carbon dioxide (co2)for the treatment of temporomandibular disorders (tmd)related pain

Conditions: Temporomandibular Disorders; Pain; Headaches

Summary: this purpose of this study is to evaluate the safety and efficacy of treatment with nasal co2 in the treatment of pain and other symptoms related to temporomandibular disorder (tmd).

this is a randomized, controlled trial evaluating the safety and efficacy of nasal carbon dioxide for the treatment of pain and other symptoms related to temporomandibular disorders (tmd). approximately 115 men and women ages 18 to 70 years old who have a history consistent with tmd-related pain for at least 3 months and meet all other eligibility criteria will be enrolled in this study. there may be up to two (2) visits to the clinic, screening and treatment. screening and treatment may occur on the same day.

Eligibility criteria:
key inclusion criteria: * have a history consistent with tmd-related pain for at least 3 months prior to screening * agree not to use certain medications prior to randomization within the study specified * females of childbearing potential must commit to using an acceptable method of birth control and have a negative pregnancy test. key exclusion criteria: * have recent history of alcohol or drug abuse within 2 years prior to randomization * current major psychiatric disorder such as suicidal ideation, bipolar, panic disorder, schizophrenic, or psychoses * history of asthma (other than mild or intermittent) * have an existing serious unstable systemic disease (such as severe emphysema, other respiratory diseases, heart disease, etc.) that precludes participation in the study * clinically significant nasal disorder (such as deviated septum, presence of polyps, evidence of significant congestion, rhinitis, or other nasal abnormalities) * current diagnosis of fibromyalgia * history or clear clinical evidence of osteoarthritis of temporomandibular joint (tmj) * a tmd diagnosis of disc displacement without reduction, "locking"

Keywords: temporomandibular disorders tmd tmj/tmd pain management pain headaches
music therapy model "the bonny method of guided imagery and music" on patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis; Quality of Life; Chronic Pain

Summary: the aim of this study is to investigate the effect of music therapy and in particular of the model "the bonny method of guided imagery and music (gim)" in patients with rheumatoid arthritis (ra) in relation to both chronic pain relief and other psychosocial parameters, as well as the effect of the method on caregiver burden.


Eligibility criteria:
inclusion criteria: * rheumatoid arthritis (ra) * over 18 years of age exclusion criteria: •none

Keywords: rheumatoid arthritis gim bonny method model
exposed versus buried intramedullary k-wires for pediatric forearm fractures

Conditions: Forearm Fracture

Summary: comparing the rate of complications between buried and exposed intramedullary implants after fixation of pediatric forearm fractures.

comparison between buried and exposed intramedullary k-wire in fixation of pediatric forearm fracture in rate of complications such as infection,malunion,nonunion and refracture.

Eligibility criteria:
inclusion criteria: 1. age: less than 10 years . 2. diaphyseal forearm fracture. 3. closed fracture. 4. isolated or combined fracture of forearm. exclusion criteria: 1. patient age: more than 10 years old . 2-open fracture. 3- pathological fracture. 4-patient with medical history (immune compromized patient e.g d.m, cancer on chemotherapy and aplastic anemia). 5- neurovascular injury.
prospective coronary heart disease cohort

Conditions: Coronary Heart Disease; Myocardial Infarction

Summary: to evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.

patients with cardiovascular disease undergoing coronary angiography will be recruited and prospectively followed up for the incidence of major adverse cardiovascular events (mace events), including all-cause mortality, cardiovascular mortality, ischemic stroke, heart failure and rehospitalization. blood and fecal samples will be collected for further analysis. the basic and clinical information will be collected such as socio-demographic, diet, lifestyle, psychological status and medical history. the biomarkers for the incidence of coronary heart disease and the factors contributing to the poor prognosis of coronary heart disease will be investigated based on multi-omics analysis.

Eligibility criteria:
inclusion criteria: * diagnosed as coronary heart disease or with unexplained chest pain needed to undergo coronary angiography. * healthy subjects undergoing routine physical examination in the physical examination department and willing to sign informed consent will be recruited as control subjects. exclusion criteria: * with malignant tumors, infectious diseases and advanced liver diseases. * won't sign an inform consent.
veteran health study

Conditions: Stress Disorders, Post-Traumatic; Depression; Diabetes; Cardiovascular Disease

Summary: the purpose of the veteran health study (csp #569) is to better understand the mental and physical health of veterans as they get older. we are inviting approximately 10,000 members of the vietnam era twin (vet) registry to participate. as veterans approach their mid-sixties, it is important to understand the impact of wartime deployment on health and mental health outcomes nearly 40 years later. the investigators will assess the prevalence of post-traumatic stress disorder (ptsd) and other mental and physical health conditions for vietnam era veterans, and explore the relationship between ptsd and other conditions. csp #569 involves 3 phases of data collection. in phase i, vet registry members are invited to complete a paper and pencil questionnaire including items on physical and mental health, disability, health behaviors, demographic information and use of health care services. after completing phase i, vet registry members are invited to phase ii which involves a telephone interview about mental health. in phase iii, some of those who participated in phase i will be invited to a sub-study confirming self-reported heart disease and diabetes using a provider survey. data collected for csp #569 will be combined with existing vet registry data. this will provide a rich picture of the health of vietnam era veterans and the influence of ptsd on the lives of veterans.


Eligibility criteria:
inclusion criteria: * all twins who are currently active in the vet registry will be invited to participate in csp #569. exclusion criteria: * unable or unwilling to provide informed consent

Keywords: stress disorders, post-traumatic depression diabetes cardiovascular disease depressive disorder behavioral symptoms metabolic diseases mental disorders anxiety disorders
clinical study to further evaluate the efficacy of dabrafenib plus trametinib in patients with rare braf v600e mutation-positive unresectable or metastatic solid tumors

Conditions: Rare Unresectable or Metastatic BRAF V600E Mutation-positive Solid Tumors

Summary: this study is a phase iv, pragmatic single-arm prospective, open label study in pediatric (6 years or older) and adult study participants with rare braf v600e mutation-positive unresectable or metastatic solid tumors for whom a decision has already been made to be treated with dabrafenib and trametinib, irrespective of the trial participation.


Eligibility criteria:
inclusion criteria: * study participant with a braf v600e mutation-positive solid tumor as confirmed by a local laboratory test; * at least 1 measurable lesion as defined by recist v1.1 per local review; * study participant previously not treated with dabrafenib and/or trametinib. study participants who received dabrafenib and trametinib in the past for the treatment of other malignancies are eligible if treatment has been discontinued for greater than 1 year; * ability to provide scans for central imaging review exclusion criteria: * those with the following tumor types: melanoma, nsclc, atc, btc, glioma and crc; * study participants who have contraindication to receive dabrafenib and/ or trametinib according to the local label;

Keywords: braf v-raf murine sarcoma viral oncogene homolog b1 dabrafenib trametinib tumor agnostic
assessment of ultrasonographic measurement of inferior vena cava collapsibility index in prediction of hypotension associated with tourniquet release in total knee replacement surgeries under spinal anesthesia

Conditions: Fluid Hypovolemia, Cerebrospinal

Summary: administration of intravascular fluids is one of the methods to prevent sa-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery. over fluid resuscitation is associated with organ dysfunction and higher mortality rate , thus, to avoid ineffective or even harmful intravascular volume expansion, it is important to have tools to predict hypotension and fluid responsiveness.


Eligibility criteria:
inclusion criteria: * asa grade i, ii, iii * age 18 -65 yrs * spinal anesthesia exclusion criteria: * patient refusal * patient having contraindication of spinal anesthesia (infection at the site of injection, spine deformity, coagulation disorders ) . * known cardiac, renal, neurological, metabolic, endocrine, psychiatric, respiratory disease.
the effect of zinc on the gingival crevicular fluid level of total oxidant capacity in type 2 diabetic patients

Conditions: Chronic Periodontitis

Summary: to evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled type-2 diabetic patients with stage-ii and iii periodontitis after non-surgical periodontal therapy.

hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and zinc supplementation is known to be helpful in restoring plasma zinc levels to normal,zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (dm2) to happen ,zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (sod), and zinc deficiency impaired their synthesis, leading to increased oxidative stress

Eligibility criteria:
inclusion criteria: * controlled type-2 diabetes mellitus * stage-ii \&iii periodontitis * at least 2 sites with clinical attachment loss 3 or 4 mm to ≥5 mm and radiographic bone loss 15% extending to mid-third of root and beyond. * probing depth from ≤5 mm to ≥6 mm exclusion criteria: * any periodontal or antibiotic treatment during the last six months. * receiving trace element supplements in the previous three months * pregnant or lactating females * gastric or diuretic treatment * acute renal failure * smoking

Keywords: zinc non-surgical periodontal therapy stage ii periodontitis stage iii periodontitis gingival crevicular fluid total oxidant capacity type 2 diabetic patients
antiemetic effect of the addition of ondansetron to the morphine solution in patient-controlled analgesia (pca)

Conditions: Postoperative Nausea and Vomiting

Summary: pca morphine always introduces nausea and vomiting during the postoperative period. ondansetron can reduce ponv (postoperative nausea vomiting). we, the researchers at khon kaen university, are trying to add ondansetron in pca morphine. patients receive a small dose of ondansetron when they request morphine.


Eligibility criteria:
inclusion criteria: * age between 15-60 years old exclusion criteria: * history of motion sickness, smoking

Keywords: ondansetron pca
preemptive use of the nicotine patch for postoperative pain relief after open abdominal surgery

Conditions: Postoperative Pain

Summary: the efficacy of a low dose nicotine patch of seven milligrams placed before surgery and its effect on decreasing pain after surgery is the main purpose of the study.

study patients include nonsmokers aged 18-75 undergoing open abdominal wall surgery under general anesthesia. if the patient smokes, receives a regional anesthetic such as an epidural, or is pregnant, then he/she is excluded from the study. there are two randomized study groups. group b receives a seven-milligram transdermal patch and group a receives a placebo patch. generic seven-milligram nicotine patches or identical placebo patches made from band-aids are glued to a 3x4 inch adhesive pad and placed on the individuals' right upper arm 1 hour before surgery. all patients are given a standardized anesthetic consisting of a narcotic infusion, propofol, a neuromuscular blocking agent, anesthetic gas agent, antinauseant medication and a nonsteroidal. patients receive postoperative analgesia for twenty four hours after surgery with a narcotic or an additional nonsteroidal medication. all patients receive intravenous controlled patient controlled analgesia (ivpca) with morphine sulfate one milligram per ten minutes, forty milligram four hour limit. patients also receive toradol fifteen milligrams for breakthrough pain. the patch is removed from participants twenty four hours post ivpca initiation. the following items are assessed every four hours for twenty four hours after post anesthesia care unit discharge: a verbal rating of pain, total ivpca morphine use, nausea occurrence, vomiting occurrence, and sedation score by the nurse.

Eligibility criteria:
inclusion criteria: * study patients include nonsmokers aged 18-75 undergoing open abdominal wall surgery under general anesthesia. exclusion criteria: * if the patient smokes, receives a regional anesthetic such as an epidural, or is pregnant, then he/she is excluded from the study.

Keywords: preemptive nicotine patch open abdominal surgery
major adverse cardiac events after carotid endarterectomy

Conditions: Carotid Stenosis; Carotid Endarterectomy; Adverse Cardiac Events

Summary: carotid endarterectomy is the operation for curing the significant carotid artery stenotic patients who are also at high cardiac risk. this retrospective study is to find out the incidence and risk factors related.

the investigator plan to retrospectively investigate 175 carotid endarterectomy patients in siriraj hospital to find the incidences of major adverse cardiac events, including * myocardial infarction is defined as rising of cardiac bio-markers in the setting of myocardial ischemia (relevant anginal symptoms, ecg changes or imaging e.g. echocardiography)2,10 * significant arrhythmia is defined as symptomatic or causing hemodynamic changes without other explainable causes. * heart failure is defined according to modified framingham criteria3 * cardiac death is defined as mortality in association and as a direct result from myocardial infarction, arrhythmia or heart failure if possible, the investigators will try to find the associate or risk factors for those events.

Eligibility criteria:
inclusion criteria: * every patients undergoing carotid endarterectomy in siriraj hospital exclusion criteria: * patients with other simultaneous surgery with carotid endarterectomy

Keywords: carotid endarterectomy adverse cardiac events
time to return of bowel function following perioperative probiotics in colorectal cancer surgery

Conditions: Colorectal Cancer; Ileus Postoperative; Flatus; Diet, Healthy

Summary: there is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. one metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (pmid:37373843). more broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (pmid: 35231076). in spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in singapore. we therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.


Eligibility criteria:
inclusion criteria: 1. undergoing elective colorectal cancer surgery in which an oncologic resection is planned 2. age between 21 and 99 years at the time of consent 3. willing to consider oral nutritional supplementation 4. on an early recovery after surgery (eras) pathway 5. able to provide informed consent exclusion criteria: 1. patients with known contraindications to probiotic use 2. patients undergoing emergency surgery 3. taking any other form of probiotics 4. taking oral antibiotics within 7 days of commencement of study 5. vulnerable patients including pregnant patients, inmates, and those who are cognitively impaired and therefore are not able to provide informed consent.

Keywords: colorectal cancer colorectal surgery nutritional supplementation probiotics time to bowel movement time to flatus length of stay complications
efficacy and safety of alx-0171 in adult hematopoietic stem cell transplant (hsct) recipients who present with respiratory syncytial virus (rsv) infection

Conditions: Respiratory Syncytial Virus Lower Respiratory Tract Infection

Summary: the primary objective of the study is to evaluate the antiviral effect and safety of inhaled alx-0171 in adults diagnosed with respiratory syncytial virus (rsv) respiratory tract infection after hematopoietic stem cell transplantation (hsct). the secondary objective is to assess the clinical activity, pharmacokinetics (pk), virology, and immunogenicity of inhaled alx 0171 in adults diagnosed with rsv respiratory tract infection after hsct.


Eligibility criteria:
inclusion criteria: 1. subject has received an hsct using any conditioning regimen and for any underlying etiology (i.e., subject has received an autologous or allogeneic hsct) 2. subject is clinically diagnosed with rsv infection with new onset or acute worsening 3. symptoms likely related to rsv infection have appeared within 5 days of screening and their severity requires initial or maintained hospitalization. 4. documented rsv infection in the upper respiratory tract (urt) 5. subject has: * diagnosis of rsv lower respiratory tract (lrt) disease or * diagnosis of rsv urt disease with high risk of progression to lower respiratory tract infection (lrti) others as defined in the protocol exclusion criteria: 1. subject has clinically significant bacteremia or fungemia within 7 days of screening 2. subject has clinically significant bacterial, fungal or viral pneumonia 3. subject presents evidence of shock requiring intensive care unit (icu) monitoring and/or vasopressor treatment 4. subject requires or is expected to require invasive mechanical ventilation or intensive non-invasive respiratory support. standard oxygen supplementation up to 6 l/minute is permitted provided it can be interrupted for the duration of study drug administration. others as defined in the protocol
oxytocin, trauma disclosure and intrusions

Conditions: Healthy

Summary: severe traumatic experiences such as falling victim to assault, torture, or rape have deleterious effects. clinical manifestations include intrusions, avoidance behavior, and hyperarousal, which are associated, at a circuit level, with hyperfunction of the amygdala and hypofunction of prefrontal cortex (pfc) subregions. in up to 50 % of the cases, resilience is not sufficient and trauma-exposed individuals develop posttraumatic stress disorder (ptsd). oxytocin (oxt) is a hypothalamic peptide hormone that exerts anxiolytic effects. recent clinical trials provide preliminary evidence that post-trauma administration of oxt could be effective as a preventive intervention for ptsd in a subsample of individuals exhibiting early ptsd symptoms prior to the onset of the disorder. however, the underlying neurobiological mechanisms are unclear. therefore, the rationale of the present project is to expose a sample of healthy participants to experimental trauma in order to explore the circuit mechanisms by which oxt influences, and interferes with, traumatic experience. functional magnetic resonance imaging (fmri) will be employed in order to elucidate the long-term effects of intranasal oxt on trauma-induced intrusions, amygdala and pfc responses during an emotional face matching task and resting state functional connectivity.

participants will be exposed to an experimental trauma (i.e. a highly aversive movie) at days 1 and 4 of the study. after the first experimental trauma and after the first functional magnetic resonance imaging (fmri) measurement, the participants will receive intranasal oxt or placebo in three different groups (1. oxt for six days, 2. oxt for three days and then placebo for three days, 3. placebo for six days). the same fmri tasks will be used after the first and second trauma exposure (i.e. one measurement before the treatment and one measurement after three days of treatment).

Eligibility criteria:
inclusion criteria: * healthy female volunteers * right-handed exclusion criteria: * current or past psychiatric disease * current or past physical illness * psychoactive medication * hormonal contraception * mri contraindication (e.g. metal in body, claustrophobia)

Keywords: amygdala, fear, intrusion, oxytocin, trauma disclosure
a study to evaluate biomarker signature to predict the persistence of post-traumatic headache

Conditions: Post-Traumatic Headache; Healthy

Summary: the purpose of this research study is to develop a model to help distinguish patients at high-risk for developing persistent post-traumatic headache from patients who experience headache recovery. researchers will do this by comparing the brain images, clinical data, and speech of healthy controls to people who have been diagnosed with post-traumatic headache.


Eligibility criteria:
inclusion criteria: * post-traumatic headache (pth) and persistent post-traumatic headache (ppth) will be diagnosed using the ichd-3 diagnostic criteria for pth attributed to mild traumatic brain injury (concussion). * for patients with pth, only patients with new onset of pth without history of ppth will be included in the study. * a personal history of prior concussion and history of migraine are allowed according to ichd-iii diagnostic criteria. * tension-type headaches on three or fewer days per month is allowed for healthy control subjects. exclusion criteria: * history of moderate or severe traumatic brain injurie (tbi). * prior history of gross anatomical change on imaging. * contraindication to mri, including but not limited to severe claustrophobia and/or presence of ferrous materials in the body. * women who are pregnant, or believe that they might be pregnant. although there are no known contraindications or risks associated with pregnancy and mri, we will exclude pregnant women or women who believe that there might be a chance that they are pregnant. * history of concussion or more severe tbi. * history of migraine or other headaches. * the diagnosis for pth and ppth will be verified by dr. schwedt (co-investigator) a board-certified physician in neurology and headache medicine. presence of concussion will be verified using the ohio state university tbi identification method, a standardized questionnaire assessing the lifetime history of tbi for an individual.