Kornimate/medical-research-clean huggingface dataset:
ganglionated plexus ablation for treatment of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this study evaluates the effect of catheter ablation of ganglionated plexi (gp) for the treatment of adult patients with atrial fibrillation heart arrhythmias. the location of gp will be demonstrated by a novel nuclear imaging cardiac camera. 3d images from the cardiac camera will guide the gp ablation procedure.

catheter ablation procedures are nowadays routine procedures in patients with drug-refractory atrial fibrillation (af). however, ablation success for patients even in the early stages of af is currently only around 70% and may require multiple procedures. the intrinsic cardiac autonomic nervous system (ans), which forms a neural network, has been shown to be a critical element responsible for the initiation and maintenance of af. autonomic inputs to the heart converge at several locations; these convergence points are typically embedded in the epicardial fat pads and form ganglionated plexi (gp) that contain autonomic ganglia and nerves. in human hearts, there are at least 7 gp and the 4 major left atrial gp are located around the antrum of the pulmonary veins (pvs). high-frequency stimulation (hfs; 20 hz, 10-150 v and pulse width 1-10 ms) can localize gp during an invasive electrophysiology (ep) study. a novel dedicated cardiac nuclear imaging camera with solid-state detectors (d-spect, spectrum dynamics) has demonstrated significantly improved sensitivity and image resolution and can provide novel imaging information on previously 'invisible' structures like the gp. using this 3d image information to guide gp ablation could significantly facilitate af ablation and result in improved ablation outcomes.

Eligibility criteria:
inclusion criteria: * paroxysmal or early persistent atrial fibrillation with ongoing af for less than 1 week * able to give written informed consent * age \>18 years old and ≤ 80 years * fulfil established clinical criteria for catheter ablation of atrial fibrillation * normal left ventricular (lv) ejection fraction and no evidence of significant structural heart disease exclusion criteria: * reversible cause of atrial fibrillation * recent cardiovascular event including transient ischaemic attack (tia) * intolerance or unwillingness to oral anticoagulation with warfarin * bleeding disorder * contraindication to computed tomography (ct) scan * presence of intracardiac thrombus * vascular disorder preventing access to femoral veins * cardiac congenital abnormality * severe, life threatening non cardiac disease * active malignant disease or recent (\<5 years) malignant disease * presence of atrial septal defect (asd) or patent foramen ovale (pfo) closure device * unable or unwilling to comply with follow-up requirements * patients on amiodarone until less than 3 months prior to the screening visit * left atrium size \> 5.5 cm on parasternal diameter in transthoracic echocardiography (tte) * renal impairment * pregnancy

Keywords: ganglionated plexi
study of inhaled glucocorticosteroid administration in asthma patients

Conditions: Asthma

Summary: once-daily inhaled glucocorticosteroids treatment can sufficiently control airway inflammation in asthma patients.


Eligibility criteria:
inclusion criteria: * receive ics for one year or more, with no change in dose within the previous 8 weeks exclusion criteria: * two or more courses of oral corticosteroid in the previous 12 months * admission to hospital due to asthma in the previous 6 months * admission to the intensive care unit due to asthma at any time in the past * current cigarette smoker.

Keywords: asthma patients well-controlled
recombinant human endostatin continued pumping into vein combining with ccrt in unresectable stage iii nsclc

Conditions: Stage III Non-small-Cell Lung Cancer

Summary: resistance of hypoxic tumor cells to radiation is a significant reason of failure in the local control of tumors, especially the squamous cell carcinomas. preclinical models have shown that endostar may transiently "normalize" the tumor vasculature to make it more efficient for oxygen delivery, thereby providing a window of opportunity for enhanced sensitivity to radiation treatment. this study is to evaluate the safety, toxicity, and efficacy of the addition of endostar continued pumping into vein to the standard ccrt regimen in patients with unresectable stage iii nsclc.

primary evaluate the efficacy and safety of endostar combined with concurrent chemo-radiotherapy (ccrt) in patients with unresectable stage iii non-small-cell lung cancer (nsclc). secondary measure changes in vegf and other angiogenic cytokines and antiangiogenic factors in plasma samples from these patients. evaluate the application of ct perfusion imaging to determine changes in tumor vascular mophology and function during treatment.

Eligibility criteria:
inclusion criteria: * untreated histologic or cytologic of nsclc verified * inoperable stage iiia or iiib nsclc * measurable disease by recist * 18\~70 years of age * an ecog ps of 0 to 1 * absolute neutrophil count (anc) of ≥1500/μl, hemoglobin ≥10gm/dl, platelet ≥100,000/μl * serum creatinine ≤1.25 times of upper limit of normal (uln), calculated creatinine clearance (crcl) of ≥60ml/min * bilirubin 1.5×uln, ast and alt less than 2.5×uln, alkaline phosphatase less than 5×uln * forced vital capacity in 1 second (fev1) higher than 0.8 l * cb6 is normal * written informed consent exclusion criteria: * a history of other malignant diseases * any contraindications for chemoradiotherapy * distant metastasis * malignant pleural and/or pericardial effusion * pregnant or nursing * preexisting bleeding diatheses or coagulopathy

Keywords: recombinant human endostatin non-small-cell lung cancer chemoradiotherapy
surgical guides effectiveness

Conditions: Atrophic Maxilla

Summary: the use of zygomatic implants is a technique that is becoming more and more widespread in daily clinical practice, however, few professionals feel safe and confident in performing this type of procedure. we therefore believe that a line of research focused on simplifying this technique will have an extraordinary impact on the safety of both patients and surgeons. currently, new surgical guides have emerged that guarantee greater precision in the placement of zygomatic implants. however, no comparative clinical studies have yet been performed to evaluate the degree of accuracy of guided implant placement compared to the conventional freehand technique.

the primary objective of the study is to study the accuracy of the use of guided surgical splints compared to traditional freehand zygomatic implant placement. the secondary objectives are: * to compare the magnitude of variations depending on implant length by superimposing postoperative ct scans using 3dslicer® (http://www.slicer.org) and exocad® software. * to compare the magnitude of the variations depending on the location of the implant by superimposing postoperative and postoperative ct scans using 3dslicer® (http://www.slicer.org) and exocad® software. * to assess the clinical relevance of cogomatic implant placement using guided surgical splinting on pain parameters and surgical time.

Eligibility criteria:
inclusion criteria: • age between 18-80 years of age, patients who sign the informed consent form and patients who consent to undergo preoperative and postoperative orthopantomography and ct scans. exclusion criteria: * smoking (more than 10 cigarettes per day). * alcoholism (more than 25g/day in women and more than 40g/day in men according to who criteria), * oncological treatment (history of treatment in the last 6 months or current treatment with chemotherapy or radiotherapy). * history of head and neck radiotherapy. * allergic to anesthetics or antibiotics.
molekule for allergic rhinitis/asthma

Conditions: Asthma; Allergic Rhinitis; Allergic Conjunctivitis

Summary: exposure to airborne allergens and pollutants is linked to symptom severity of allergies, asthma and other respiratory problems. in this study an air purifier using photo-electrochemical oxidation technology (peco) will be used in the home environment of study participants. the investigator will assess the reduction of symptoms from allergic rhinitis/conjunctivitis and asthma.

the purpose of this study is to assess the efficacy of the portable peco air purifier in reducing symptoms from allergic rhinitis and asthma. using a randomized, double blinded placebo, controlled trial we will be then able to assess if there are any changes after the use of the peco air purifier after completing an initial baseline survey \& comparing to the exit survey. this is a double-blind study, which means that neither the participant nor the investigator knows which device is being used until after the trial is over.

Eligibility criteria:
inclusion criteria: 1. chronic allergic rhinitis and/or conjunctivitis by history 2. history of adult asthma requiring medications now or in the past 3. age ≥18 4. carat score less than 24 exclusion criteria: 1. participant is \<18 years-old 2. use of systemic corticosteroids within 14 days of study initiation 3. treatment with biologic agents or allergen immunotherapy 4. treatment with other immunomodulators (cyclosporine, azathioprine, hydroxychloroquine, etc) 5. sensitive to fan sound or blue/purple light at night time

Keywords: asthma environmental intervention allergies air purifier
postoperative pain for patients after ta-bsm

Conditions: Nerve Block; Transapical Beating-heart Septal Myectomy

Summary: to retrospectively analyze the intraoperative and postoperative status of patients with hypertrophic cardiomyopathy undergoing ta-bsm, and to estimate whether paravertebral nerve block can improve postoperative pain for these patients.

since conventional septal myectomy can be only assessed when the heart resumes beating, and the complications induced by cardiopulmonary bypass are inevitable, a novel transapical beating-heart septal myectomy (ta-bsm) has been invented, which provides real-time evaluation to guide resection while reducing surgical trauma. postoperative pain after ta-bsm is unknown. whether paravertebral nerve block can improve postoperative pain caused by ta-bsm is the objective of our study.

Eligibility criteria:
inclusion criteria: * age 18\~75 years * american society of anesthesiologists classification ii-iii * elective ta-bsm was performed exclusion criteria: * underwent multiple surgical procedures or required cardiopulmonary bypass assistance * combined other function decompensation disease * patients with incomplete medical records
a randomized clinical study comparing a fully-coated cementless stem versus a cemented stem for total hip replacements

Conditions: Osteoarthritis

Summary: the purpose of this study is to answer the question as to whether or not a fully coated cementless stem is equal to or better than a cemented stem in patients over 72 years with good bone quality.


Eligibility criteria:
inclusion criteria: * adult patients undergoing surgery for total hip replacements, including diagnosis of osteoarthritis, rheumatoid arthritis, traumatic and post-traumatic arthritis, avascular necrosis and congenital dislocation of the hip. congenital dislocation of the hip will be included where small but anatomical acetabuli are present, ie., the acetabuli located near the tear-drop * revisions of failed osteotomies may be included * bone quality felt to be acceptable to the surgeon for cementless arthroplasty preoperatively in patients \> 72 years of age exclusion criteria: * patients with active infection * revision cemented total hip replacement * charcot joints * patients with primary or secondary bone tumors in the vicinity of the joint to be replaced * c.d.h. with abnormally placed acetabuli or femoral canals * fibromyalgia patients
endotoxin and inflammatory markers in healthy non-smokers and current smokers including patients with chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the primary aim of this study is to investigate the effects of inhaled lipopolysaccharide endotoxin (lps) on bronchial and alveolar exhaled nitric oxide (no) and no metabolites and other inflammatory markers and mediators in exhaled breath condensate, induced sputum, nasal lavage and mouthwash fluid in healthy non-smokers and current smokers, including patients with chronic obstructive pulmonary disease (copd).


Eligibility criteria:
inclusion criteria: * healthy non-smokers: normal spirometry (forced expiratory volume in 1 second \[fev1\] more than or equal to 90% predicted) and normal exhaled no (between 8 and 24 ppb; flow 50 ml/s) * 0: at risk (current or ex-smokers): normal spirometry, with or without chronic symptoms (cough, sputum production) * i-ii: mild-moderate copd * fev1 reversibility of \< 15% after inhaled beta2-agonists * fev1/forced vital capacity (fvc) \< 70% predicted * fev1 between greater than or equal to 50% and less than 80% * with or without chronic symptoms (cough, sputum production) * able to comprehend and grant a written informed consent exclusion criteria: * concomitant use or pre-treatment within the last 4 weeks with oral steroids * respiratory infection within 4 weeks prior to entry into the trial * females who are pregnant or lactating * history of current or past drug or alcohol abuse

Keywords: mild to moderate chronic obstructive pulmonary disease (copd) volunteers (healthy non-smokers) volunteers (current or ex-smokers)
comparison between iort and postoperative radiotherapy in breast conserving surgery

Conditions: Quality of Life

Summary: to compare the satisfaction with conserved breast, acute and chronic postoperative complications and tumor control between intraoperative radiotherapy(iort) and traditional postoperative radiotherapy following breast-conserving surgery (bcs).


Eligibility criteria:
inclusion criteria: * primary invasive breast cancer confirmed by pathology. * maximum tumor diameter ≤3.5cm. * clinical lymph nodes are negative. * single or multiple tumors are located on the same side of the nipple and in the same quadrant. * ecog status score ≤ 2. * with informed consents. exclusion criteria: * previous history of breast cancer or other malignant tumors. * inflammatory breast cancer; 3. previous radiotherapy history. * other diseases affecting radiotherapy, such as connective tissue disease, heart disease, lung disease and so on. * patients who are not going to have the axillary lymph node surgery (including sln and alnd) were excluded.

Keywords: intraoperative radiotherapy breast-conserving surgery
a study of ocrelizumab in combination with methotrexate in patients with rheumatoid arthritis who are naive to methotrexate (film)

Conditions: Rheumatoid Arthritis

Summary: this study will evaluate the efficacy and safety of ocrelizumab, compared with placebo, in combination with methotrexate in patients with active rheumatoid arthritis who are naive to methotrexate. patients will be randomized to receive placebo, ocrelizumab 200mg i.v. or ocrelizumab 500mg i.v. on days 1 and 15. repeat courses of i.v. treatment will be administered at weeks 24, 52 and 76. all patients will receive concomitant methotrexate (7.5 mg escalating to 20mg p.o. weekly). the anticipated time on study treatment is 2+ years, and the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * rheumatoid arthritis for 3 months-5 years * naive to methotrexate * if receiving steroids or nsaids, must be on a stable dose for 4 weeks prior to baseline exclusion criteria: * rheumatic autoimmune disease or inflammatory joint disease other than ra * prior receipt of any biologic therapy for ra * concurrent treatment with any dmard

Keywords: film ra anti-cd20 cd20
effects and perception of intensive virtual reality training on upper limb functions after stroke

Conditions: Stroke

Summary: previous literature review shows limited work on upper limb recovery from virtual reality device and most of them are pilot studies meta-analysis some randomized control trial studies are done but this study will cover mixed method including both qualitative and quantitative method.

stroke is the leading cause of disability worldwide approximately 80% of stroke survivors regain ability to walk, 30 - 66% of survivors are not able to use their affected upper limb mobility. with improving survival rates and longer life expectancy in general, the burden of caring for stroke survivors is likely to increase. as a lack of upper limb recovery results in significant dependence and a reduced quality of life. persistent upper limb (ul) dysfunction after a stroke is one of the most challenging issues in rehabilitation. effective upper limb treatment interventions have therefore been identified as a priority for stroke research. one of the rehabilitation strategies include performing self-administered exercises using vr games technology. effective treatment interventions post-stroke is characterized by high intensity and repetitive practice of a meaningful task. however, changes in infrastructure, an emphasis on mobility during early rehabilitation ,to reduce hospital length of stay and a lack of therapy on discharge home have resulted in challenges delivering the amount of rehabilitation necessary to optimize recovery. a promising technique, which has the capability of creating an interactive environment in which practice intensity and feedback can be manipulated to retrain movement in the upper limb in people with stroke, is virtual reality (vr) technology .vr provides a sense of illusion: of being immersed in a world where objects can he visualized and interact with. the system is usually a controlled one, where the objects and interaction styles (point, touch, grasp) are defined prior to the controlling program being executed. there are a number of ways in which the virtual environment (ve) can he presented to the user. most common are desktop (fish tank) vr systems where the ve is displayed on a standard desktop monitor. the user can interact with the environment via standard hardware (keyboard, mouse) or via specialized vr devices such as data gloves, hut is conscious of 'looking at' the environment rather than 'immersed in' the environment.

Eligibility criteria:
inclusion criteria: 1- subacute and chronic stroke patient \> 3 months post stroke till 1 year. 2. both gender 3. age: 40-70 years 4. modified ashworth scale1-3 5. mmse\>25 6. able to follow verbal instructions related to the use of vr devices exclusion criteria: 1. neurological disorders other than stroke. 2. aphasia that would limit the ability to follow verbal instructions. 3. participation in other upper extremity therapies during the study

Keywords: intensive virtual reality upper limb functions
anti-histamines and methacholine challenges.

Conditions: Asthma

Summary: the asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. the use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction. if using methacholine, this may also be true depending on whether old (e.g. benadryl) or new (e.g. desloratadine) antihistamines are used. this study will look at the effect of old and new antihistamines on inhaled methacholine challenge response in individuals with mild asthma.


Eligibility criteria:
inclusion criteria: * baseline forced expiratory volume in 1s (fev1) of 70% or more of predicted * methacholine provocative concentration causing a 20% fall in fev1 16mg/ml or less * no respiratory infection or change in allergen exposure for 4 weeks prior to screening and throughout the study * no significant medical co-morbidities * allergy exclusion criteria: * pregnant or breastfeeding females * unable to withhold antihistamines, anticholinergics, long acting bronchodilators and combination therapies

Keywords: airway hyperresponsiveness
18f-fdg pet/ct in the diagnosis of tuberculous pericarditis

Conditions: Diagnostic Self Evaluation

Summary: a total of 11 patients confirmed with tuberculous pericarditis were enrolled in this study to analyze the diagnostic value of 18f-fdg pet/ct for tuberculous pericarditis.

a total of 11 patients with tuberculous pericarditis, who underwent 18f-fdg pet/ct from january 2015 to february 2022 in the affiliated hospital of jiangnan university were retrospectively reviewed in this study to analyze the diagnostic value of 18f-fdg pet/ct in tuberculous pericarditis.

Eligibility criteria:
inclusion criteria: patients confirmed as tuberculous pericarditis through follow-up. exclusion criteria: patients confirmed as other pericarditis through follow-up.
establishing correlation between non-invasive pulmonary blood pressure readings and swan-ganz results

Conditions: Congestive Heart Failure

Summary: pulmonary hypertension (ph) is prognostic indicator in heart failure patients for poor outcome, however, it is challenging for monitoring. the current study is designed to explore whether data generated using suremedix device including a pump and non-invasive sensors including, chest motion sensor, photoplethysmography (ppg), and electrocardiography (ecg), can be used to identify detectable oscillations that are correlated with the mean, the diastolic and the systolic pressure values of the pulmonary artery, as measured using the gold-standard swan-ganz method.


Eligibility criteria:
inclusion criteria: * heart failure patient scheduled for right heart catheterization (swan-ganz) * age range: 18 - 80 years * pulmonary artery systolic pressure values ≤50 mmhg according to swan - ganz measurement * able and willing to sign informed consent exclusion criteria: * history or current diagnosis of asthma or any other significant pulmonary disease * jugular access site * atrial fibrillation * prior lung volume reduction surgery, lobectomy or pneumonectomy, or lung transplantation * requirement for any ventilator support (including cpap or bpap) * use of long-term oxygen therapy * known upper airway obstruction * known susceptibility to pneumothorax or pneumothorax in the medical history * chest surgery or pacemaker implantation in the prior 6 months * significant primary valvular disease * major cardiovascular event within the prior 3 months * current heavy smoker (more than one pack per day) * any diagnosed respiratory tract infection (including upper respiratory tract), airway or lung disease or copd exacerbation in the prior 3 months * female patient pregnant or breast-feeding or planning to be pregnant in the next year * diagnosis of obstructive sleep apnea * unexplained muscle weakness. unable to comfortably lie down for 30 minutes * current hospitalization due to chf deterioration * patients with a body mass index (bmi) ≥ 40kg/m2 * any condition that the pi believes could interfere with the intent of the study or would make participation not in the best interest of the patient
upper limb rehabilitation after stroke assisted with a hybrid electrical stimulation (es)-robot system

Conditions: Stroke

Summary: the purpose of this study is to investigate the combined training effectiveness of mechanical robot and neuromuscular electrical stimulation on upper limb rehabilitation after stroke.


Eligibility criteria:
inclusion criteria: the recruited subjects will * have unilateral ischemic brain injury or intracerebral hemorrhage at least 6 months after the onset of single stroke * have moderate level of motor impairment in the affected upper limb, assessed by fugl-meyer assessment (9\<shoulder/elbow\<27; 6\<wrist/hand\<18) * have enough cognition to be able to follow the training protocol as assessed by mini-metal state examination (mmse\>21) * have detectable emg signals (3 times of the standard deviation above the baseline) from the upper limb muscles.