Kornimate/medical-research-clean huggingface dataset:
a guided internet intervention for women treated for gynecological cancer

Conditions: Quality of Life

Summary: gynecological cancers are the sixth most common cancer forms and the number of survivors is increasing as a consequence of more efficient treatment and longer life span. as part of regulary care after cancer treatment the women have five years of follow-up with the primary focus on recurrence, aiming to increase survival. however, several studies have shown that there is no evidence for this assumption on increased survival (ref). there are now suggested alternative perspectives in the follow up period targeting late effects, health-related quality of life (qol) and patient satisfaction with care.the main aim of the current study is to test the feasibility and acceptability of an internet-based psychosocial intervention for women treated with curative intent gynecological cancer. another aim is to test the perceived effect on gynecological cancer survivors health-related self-care and qol.

the study's objectives and research questions research questions 1. how did the participants use the program? 1. what are the barriers and facilitators concerning technologies of the internet-based self -management intervention? 2. number of logins 3. how much time did the participants spend on the program (per login ) 4. number of modules completed, number of home-work and mindfulness assignment completed 5. type of errors made ... 2. what is the participants' perceived credibility of the program? 3. how do the participants experience the guided psychosocial digital intervention? 1. how do participants experience the cancer trajectory, their every-day lives and health-related qol post-treatment gynaecological cancer (before the intervention)? 2. how do the participants experience the internet-based intervention regarding content, the home-work assignments, and the mindfulness assignments, the active participation? 3. how do the participants experience the telephone-contact and follow-ups with the nurse once a week? 4. which factors do they describe as important for their satisfaction and dissatisfaction 4. how is the perceived effect on the gynecological cancer survivors' competence, qol, self-care and coping? it is hypothesized that an internet-based psycho-social intervention will support women in developing self-competence and self-care which could be measured as increased qol and secondarily affect the impact of cancer, distress, anxiety, depression, self-esteem, and self-reported ability to monitor and respond to symptoms of recurrence.

Eligibility criteria:
inclusion criteria * have had gyneocological cancer * maximum 1 year after gynecological cancer exclusion criteria: * severe medical or psychiatric condition * relapse of gynecological cancer

Keywords: cancer
efficacy study in patients with acne vulgaris.

Conditions: Acne Vulgaris

Summary: safety and efficacy study in patients with acne vulgaris

randomized, double-blind, placebo controlled, parallel-group, multiple-center study to evaluate the efficacy and safety of adps in the treatment of acne vulgaris.

Eligibility criteria:
inclusion criteria: * healthy male or non pregnant female aged ≥ 9 years with a clinical diagnosis of acne vulgaris exclusion criteria: * female subjects who are pregnant, nursing or planning to become pregnant during study participation.
natural history study in huntington disease gene expansion carriers (hdgecs) - shield hd

Conditions: Huntington Disease

Summary: shield hd is an international, multisite, prospective, longitudinal cohort natural history study to assess the natural history of hd and its biomarkers that are associated with modulation of the number of cytosine-adenine-guanine (cag) repeats in the mutant huntingtin (htt) gene. approximately 60 patients will be enrolled into the study and followed for up to 24 months at clinical sites in north america and europe. the results of this study will inform assessments for a future interventional treatment trial.

the rationale for this study is to obtain longitudinal information related to somatic instability and dna damage response genes in hdgecs at various stages of the disease. established assessments of disease progression will also be recorded.

Eligibility criteria:
key inclusion criteria patients who meet all of the following criteria will be eligible to participate in the study: 1. capacity to comprehend the study objectives and procedures 2. documentation of genetically confirmed disease by direct dna testing, defined as a cag repeat length ≥39 in the htt gene 3. ability to undergo and tolerate mri scans 4. ability to tolerate blood draws and lumbar punctures key exclusion criteria patients who meet any of the following criteria will be excluded from participation in the study: 1. any conditions, including severe chorea and dementia, that would prevent either writing or performing pen and paper, tablet, or computer based tasks as determined by the investigator 2. treatment with an investigational drug within 30 days prior to screening or within 5 half lives of the investigational drug, whichever is longer 3. history of gene therapy or cell transplantation or any other experimental brain surgery

Keywords: hd
dc vaccine combined with cik cells in patients with esophagus cancer

Conditions: Esophagus Cancer

Summary: the aim of this phase i/ii study is to evaluate the safety and efficacy of dendritic cells(dc) combined with cytokine-induced killer (cik) cells in patients with advanced esophagus cancer. experimental recombinant adenovirus coded mrna including muc1 and survivin that transfected dc, which are used for dc-based immunotherapy. based on the results of our previously performed preclinical study with dc vaccine combined with cik cells, the researcher plan to perform the clinical trial.


Eligibility criteria:
inclusion criteria: * histopathologically confirmed diagnosis of esophagus cancer * age \>18 years at time of consent * received standardized treatment of small-cell lung cancer * interval between the last standardized treatment and dc/cik treatment ≥ 4weeks * kps (karnofsky performance scale) \>60 * patient's written informed consent * no severe viral or bacterial infections * predicted survival \>3 months exclusion criteria: * serious dysfunction of vital organs(heart, liver or kidney) * history of autoimmune diseases * pregnant and breast-feeding patient * active or chronic infectious diseases * history of allergy or hypersensitivity to study product excipients * currently participating in another clinical trial * received chemotherapy, radiotherapy, immune inhibitor (such as corticosteroid) or other immunotherapy (such as vaccine) during prior 4 weeks * clinically relevant diseases or infections (hbv, hcv, hiv)
a study of ibi306 in participants with hypercholesterolemia

Conditions: Hypercholesterolemia

Summary: this study is designed for multi-center, double-blind, randomized, placebo-controlled phase iii trial to evaluate the safety and tolerability of subcutaneous injection of ibi306 in hypercholesterolemia patients.


Eligibility criteria:
inclusion criteria 1. males and females ≥ 18 to ≤ 75 years of age 2. diagnosis of hypercholesterolemia 3. ldl cholesterol ≥ 70 mg/dl (1.8mmol/l) 4. very high or high cardiovascular risk 5. tg≤500 mg/dl(5.64 mmol/l) exclusion criteria 1. uncontrolled hypertension 2. uncontrolled hyperthyroidism or hypothyroidism 3. severe renal dysfunction 4. known sensitivity to any of the products to be administered during dosing
mitigating sexual stigma within healthcare interactions improve engagement of msm in hiv prevention

Conditions: Human Immunodeficiency Virus; Stigma, Social; Patient Engagement

Summary: the purpose of this study is to explore drivers and mitigators of anal sex stigma in healthcare, and then to develop and pilot an intervention for health workers that mitigates the deterrent effects of this stigma on the engagement of gay and bisexual men in hiv-related services.

this 5-year study aims to understand determinants that perpetuate and mitigate stigma toward anal sex during healthcare encounters, in order to develop and pilot a strategy that responds to these determinants and thereby improves the quality of care and hiv service engagement among men who have sex with men (msm). the study team collected data during in-depth interviews with 20 adult msm as well as 20 adult healthcare workers (hcws) to identify strategies that could be readily used in health services to reduce stigma. analysis of this data then informed consultation with an advisory board of hcws and healthcare consumers (not limited to msm), to develop the content of a set of implementation strategies to mitigate stigma and thereby improve health service delivery. evaluation of a set of implementation strategies was performed in the southern us, a high incidence region, by pilot testing with 65 adult hcws who in clinical sites where msm are under-engaged in hiv services.

Eligibility criteria:
msm participants inclusion criteria: 1. be aged 18 or older 2. report being assigned male at birth and identifying currently as male 3. reside in the united states 4. read and communicate in english 5. have had anal intercourse with a man in the past year or intend to in the next year exclusion criteria: not applicable healthcare worker participants inclusion criteria: 1. be aged 18 or older 2. read and communicate in english 3. bear a role responsibility for hiv-related screening and referral (e.g., as a peer/outreach worker, test counselor, case manager, social worker, medical assistant, nurse, physician assistant, physician) exclusion criteria: not applicable

Keywords: implementation science health stigma and discrimination framework theoretical domains framework theory and techniques tool anal sex stigma men who have sex with men sexual and gender minority
a study of exclusion criteria in a university population

Conditions: Influenza

Summary: much of community transmission of seasonal and pandemic influenza occurs in younger individuals, because of their susceptibility and their social interaction patterns.universities are places where transmission of influenza is facilitated because of the age of individuals involved, their close contact with each other, and low vaccination coverage. staying home when you are sick (i.e., voluntary sequestration) has been identified as one of the most efficient ways to reduce influenza transmission, but there are still insufficient data on the effects of social distancing to be able to make recommendations for future pandemics or even outbreaks of seasonal influenza. the investigators are conducting a study on the effect of voluntary sequestration during illness on the transmission of influenza among social networks in university residence housing units at the university of michigan. the sequestration interventions will be carried out during a period of influenza transmission that is defined by surveillance conducted at the university health service. data will be collected on use of the interventions and the occurrence of influenza and other illnesses. in all selected residence halls, specimens will be collected when illness meeting a case definition for influenza-like illness occurs. this study in a university population will evaluate the acceptability and magnitude of effect that can be expected from such an intervention, and determine the number of days that sequestration should be practiced.


Eligibility criteria:
inclusion criteria: * live in a participating residence hall at the time of enrollment * be at least 18 years of age * be willing to report social habits and illness information electronically on a weekly basis * be willing to have a throat swab specimen collected if you have signs of illness during the influenza season * be willing to nominate close social contacts living in eligible residence halls for participation in the study * be willing to participate in a 3-day sequestration protocol as randomly assigned. exclusion criteria: * non-residence in selected residence halls * unwillingness to participate in voluntary sequestration protocol and complete online surveys * already study employee

Keywords: influenza non pharmaceutical intervention sequestration social network
attentional focus instructions and conscious movement processing in older adults

Conditions: Fall Injury; Walking, Difficulty; Gait, Unsteady

Summary: this study aims to provide a novel scientific contribution through addressing critical knowledge gaps, examining the effects of attentional focus instructions on real-time (state) conscious movement processing propensity, gait parameters, and muscle efficiency in older adults in hong kong at risk of falling while walking in a challenging environment. the study results could update our scientific understanding of the mechanisms of conscious movement processing and the interventional effects of attentional focus instructions in older adults. it could ultimately enhance the methodology used for developing the most appropriate psychomotor gait re-education intervention in rehabilitation and provide clear guidelines on the exact attentional focus training that older adults require. further, it could mitigate the effect of conscious movement processing and risk of falling in older adults.


Eligibility criteria:
inclusion criteria: * age 65 or above; * able to walk independently indoor for at least 20 metres without a walking aid. exclusion criteria: * a total score of less than 24 on the mmse-c (chiu et al., 1994; folstein et al., 1975); * the presence of any untreated cerebral vascular disease, parkinson's disease, or any other major neurological deficit; * the presence of an unstable medical condition affecting safety while walking ; * a history of a major fall incident within the last year; * a static visual acuity poorer than 20/40 vision (assessed using the tumbling e eye chart).

Keywords: attentional focus instructions conscious movement processing walking muscle efficiency gait parameters
effect of transjugular intrahepatic portosystemic shunt on oxygenation in cirrhotic patients with hepatopulmonary syndrome

Conditions: Hepatopulmonary Syndrome

Summary: to prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (tips) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (hps).


Eligibility criteria:
inclusion criteria: * presence of cirrhosis * alveolar-arterial oxygen gradient ≥ 15 mm hg (≥ 20 mm hg for age \> 64 years) * positive contrast-enhanced echocardiography exclusion criteria: * age of less than 18 years * intrinsic cardiopulmonary disease * malignancy * active infection * pregnancy * previous shunt therapy * refusal to participate
combining tongue and gastric cancer cascade with artificial intelligence

Conditions: Artificial Intelligence; Tongue; Gastric Cancer

Summary: this study combines artificial intelligence with tongue images, by collating and collecting tongue images and diagnostic and pathological results of gastroscopic diseases, mining and analysing the correlation between tongue images and olga, olgim stages, correa sequences and constructing prediction models, to deeply investigate the relationship between tongue images and precancerous diseases, precancerous lesions and gastric cancer.

firstly, tongue pictures and patient information will be collected after the patient signed an informed consent form. secondly, after the patient undergoes gastroscopy, patient gastroscopy reports and pathology reports will be obtained. thirdly, the investigator will assess the patient's gastroscopy report for the correa sequence of gastric cancer with olga and olgim staging. finally, the patient's tongue image, information and gastric cancer cascade response are matched to construct an artificial intelligence model and assess the quality of the model.

Eligibility criteria:
inclusion criteria: * patients between 40 and 80 years of age who are scheduled for gastroscopy. * patients all gave their informed consent and signed the informed consent form. exclusion criteria: * persons with severe cardiac, cerebral, pulmonary or renal dysfunction or psychiatric disorders who are unable to participate in gastroscopy. * patients with previous surgical procedures on the gastrointestinal tract. * patients taking bismuth or other staining drugs.

Keywords: artificial intelligence tongue gastric cancer
milk supplementation and bone health in children

Conditions: Bone Density Increased; Body Height

Summary: objectives: to examine the effects of a yili child formula milk and regular milk on bone health and growth in young children. study design: cluster randomized controlled trial. setting: kindergartens in hui-ning county of gansu province, china (north west). participants: \>=246 apparent healthy children aged 4-6 years old. interventions: (i) yili child formula milk (qq star formula, sci-pro nutr5+6tm), 195 ml \*2 /day; (ii) yili regular milk (pure milk), 195ml\*2 /day; (iii) controls: about 50g/d grain foods (containing 20-30 g carbohydrates), e.g. bread. interventional duration: 12 months. outcome measures: determined at 0, 6 and 12 months post treatments. primary outcomes: bone density and bone mineral contents at the forearm and heel, bone biomarkers. secondary outcomes: (1) anthropometric indices: weight, height, waist circumference, etc.; (2) immune status. other measures: dietary intakes, physical activities, general information, medical information, adverse of side effects. data analyses: the one-year changes and percent changes in the primary and secondary outcomes will be compared among the 3 groups.


Eligibility criteria:
inclusion criteria: * aged between 4-6 years; * female and male * can be enrolled into kindergarten/school as a normal child. * be willing to drinking milk daily. exclusion criteria: * milk allergy or intolerance, did not to be used to drinking milk; * had the following diseases/conditions confirmed by a hospital: serious diseases of heart, liver, kidney, brain, hematopoietic system, immunity, thyroid or cancer that need to be hospitalization for more than 1 week or take medication(s) for more than 1 month with the past two years. * having infectious diseases, e.g., tuberculosis, hepatitis, etc. * taking vitamin d, calcium tables or nutrient package; * consumed more than 3 times (\>600ml) milk each week in the previous month. * be not willing to provide informed consent, or have other conditions that were considered to be unsuitable for the study by the investigators. * increases of body health were out of the range between 5-8 cm in the last year.

Keywords: milk bone health body growth young children
a study of loading doses of intravenous bondronat (ibandronate) in patients with breast cancer and malignant bone disease.

Conditions: Pain; Bone Neoplasms; Neoplasm Metastasis

Summary: this single arm study will assess the efficacy and safety of loading doses of intravenous bondronat in patients with breast cancer and malignant bone disease experiencing moderate to severe bone pain. patients will receive an intravenous infusion of 6mg bondronat on days 1, 2 and 3. the anticipated time on study treatment is 3 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * female patients, \>=18 years of age; * breast cancer; * bone metastases; * moderate to severe pain; * adequate renal function. exclusion criteria: * bisphosphonate treatment within 3 weeks of study enrollment.
analgesic effect of non invasive stimulation : comparison of rtms and tdcs efficacy

Conditions: Pharmacoresistant Neuropathic Pain

Summary: the aim of this study is to compare analgesic efficacy of two non invasive techniques based on motor cortex stimulation in neuropathic pain patients. high frequency repetitive transcranial magnetic stimulation (hf-rtms) of primary motor cortex has been demonstrated to induce an analgesic effect significantly different from placebo; this effect is clinically useful if rtms sessions are applied daily during five consecutive days. transcranial direct current stimulation (tdcs) is a new approach of non invasive cortical stimulation but its efficacy in neuropathic pain has been not yet established. the investigators propose to compare the analgesic effect of 5 tdcs sessions applied daily to a similar protocol using hf-rtms. in parallel to the clinical therapeutic evaluation, functional-mri will be performed before and after the five sessions of rtms and tdcs, in order to reveal the potential plasticity induced within motor somatotopic map of the primary motor cortex.


Eligibility criteria:
inclusion criteria: * patients aged from 18 to 80 years, male or female, fully informed and having given their written consent * pharmacoresistant neuropathic pain during at least one year, without any change of the pharmacological treatment since at least one month exclusion criteria: * drug addiction, headache, epilepsy history * ferromagnetic intracranial device * implanted stimulator * absence of contraceptive method for women of childbearing age

Keywords: pain neuropathic cortical stimulation motor cortex plasticity rtms tdcs
comparing outcomes of elbow extension tendon transfers

Conditions: Cervical Spinal Cord Injury

Summary: active elbow extension has significant functional benefits for individuals with tetraplegia. the proposed work will provide information to assess how effectively people are using their elbow extension tendon transfers, and whether one surgery works more effectively than the other. this study will provide recommendations to clinicians about the possibility of improving function after surgery using rehab techniques.

voluntary control of elbow extension significantly improves functional abilities for individuals with tetraplegia. as a result, surgical reconstruction of elbow extension via tendon transfer is considered a fundamental intervention that benefits the patient, even if other tendon transfers aimed at improving hand function are never performed. presently, there are two common tendon transfer surgeries used to restore elbow extension following spinal cord injury. these are the posterior deltoid to triceps transfer and the biceps to triceps transfer. both surgeries significantly improve voluntary elbow extension, although there is variability in the amount of control that is restored among patients. this study will directly compare the performance of the posterior deltoid transfer to the biceps transfer with regard to: voluntary elbow extension strength, the ability to activate the transfer, and neural factors associated with voluntary and involuntary control of individual muscles. these comparisons will be made in functionally relevant postures and will provide fundamental information that will improve clinical understanding of the capacity of each of these two procedures to restore elbow extension. the fundamental hypothesis of this proposal is that an inability to maximally activate the transferred posterior deltoid and the transferred biceps significantly limits the elbow extension moment that can be produced.

Eligibility criteria:
inclusion criteria: * cervical spinal cord injury (c5-c7) * posterior deltoid to triceps tendon transfer at least one year post-surgery * biceps to triceps tendon transfer at least one year post-surgery exclusion criteria: * subjects will be excluded from the studies if there is presence of concurrent severe medical illness, including: * unhealed decubiti * use of baclofen pumps * existing infection * cardiovascular disease * significant osteoporosis (as indicated by a history of fractures following injury) * or a history of pulmonary complications or autonomic dysreflexia

Keywords: tendon transfer elbow