Kornimate/medical-research-clean huggingface dataset:
reproductive health program in patients with cancer

Conditions: Malignant Neoplasm

Summary: this clinical trial studies reproductive health program in patients with cancer. a reproductive health program may improve patients' understanding of reproductive risks and receipt of appropriate treatment to achieve their reproductive health goals.

primary objectives: i. to evaluate the success of the implementation of reproductive health programming (didactics, engendering reproductive health within oncologic survivorship \[eros\] reproductive health assessment and eros trial algorithm) among reproductive aged females (15-55) with cancer. secondary objectives: i. to assess the degree of discrepancy between patients and their clinicians in estimates of significance of the reproductive health goals for the patient. ii. to evaluate baseline and follow-up reproductive health assessments for trends in reproductive health choices relating to oncofertility, oncocontraception and pregnancy over the 2-year study period. iii. to identify clinical and demographic factors that predict the adequacy of reproductive health care management. tertiary objectives: i. to perform a longitudinal study following endocrine markers of fertility in a cohort of the first 200 registered eros trial patients who agree to participate. ii. to perform a longitudinal study of sexual function using the patient-reported outcomes measurement information system (promis) sexual function survey in all subjects participating in the eros trial. outline: participating institutions are randomized to 1 of 2 arms. patients are assigned to a study arm depending on the institutional assignment. arm a: patients undergo usual standard practice related to reproductive health. arm b: patients undergo reproductive health program comprising didactics, reproductive health assessment and navigating algorithm, and network development. after completion of study intervention, patients are followed up periodically.

Eligibility criteria:
inclusion criteria: * female patients presenting with initial diagnosis of any type of cancer, including patients with ductal carcinoma in situ (dcis) * pre-menopausal patients within the reproductive age range of 15-55 years; pre-menopausal is defined as females meeting the following criteria: * patients not currently on hormonal contraception with the presence of menses in the past 6 months * if no menstruation in the past 6 months, without hormonal manipulation, then confirmed follicle-stimulating hormone (fsh) \< 23mlu/ml * if age \< 47 years and on hormonal contraception, then patient will be eligible regardless of menstrual history * if age ≥ 47 years and on hormonal contraception, then fsh confirmed \< 23miu/ml * pregnant women are eligible to participate in this study * patients must have the cognitive ability to participate in the study exclusion criteria: * patients who have initiated chemotherapy, radiation therapy or endocrine therapy prior to registration to this study * prior hysterectomy, bilateral oophorectomy or sterilization of any method

Keywords: reproductive health
the effect of nebulizied nitroglycerin as an adjuvant therapy for persistent pulmonary hypertension of newborns

Conditions: Persistent Pulmonary Hypertension of the Newborn; Echocardiography; Respiratory Disease

Summary: this aim of the study is to evaluate the effect of nebulized nitroglycerin on echocardiographic (biventricular function, pulmonary artery pressure, pda and pfo shunting and tissue doppler imaging) and clinical parameters (oxygen saturation index, heart rate, blood pressure, mean airway pressure, ventilation setting) in patients with pphn.


Eligibility criteria:
inclusion criteria: * infants ≤72 hours' old, ≥37 weeks of gestation, ≥50% fio2 need despite lung recruitment, abnormal oxygen saturation index or echocardiographic signs of pphn will be enrolled in the trial. exclusion criteria: * • diagnosis of pphn discovered after more than 72 hours. * failure of used medications and need to administrate milrinone
reversing poor graft function with eltrombopag after allogeneic hematopoietic cell transplantation

Conditions: Leukemia; Graft Failure

Summary: poor graft function (pgf) after allogeneic hematopoietic cell transplantation (allo-hct) is a misunderstood complication associated with poor outcome and limited therapeutic options. despite the lack of standardized diagnostic criteria, pgf is commonly defined as follows: one or several significant cytopenias after allo-hct persisting or developing after allo-hct despite full donor chimerism and in the absence of relapse or other causes. not only pgf can alter patients' quality of life by leading to recurrent transfusions, bleeding events and infections, but it is also associated with poor survival after allo-hct. although pgf is relatively frequent, there is no well-codified behavior in the literature or in the recommendations issued by the various learned societies of transplantation. the aim objective of the investigator's study is to demonstrate that eltrombopag improve pgf after allo-hct


Eligibility criteria:
inclusion criteria: * diagnosis of poor graft function defined as: * patient ≥ day+60 after allo-hct, * persisting thrombocytopenia on two different samples over at least two weeks (platelet \< 30g/l with transfusion requirement) +/- neutropenia (anc \<1g/l) +/- anemia (hb \<8g/dl or transfusion requirement), * full donor chimerism on whole blood (≥ 95%), * biopsy proven hypocellular marrow without evidence of myelodysplasia * no evidence for relapse, * no evidence for active acute or chronic graft versus host disease, * absence of active viral infection (ebv, cmv, adenovirus, parvovirus b19), * absence of b9/b12 deficiency, * absence of hypothyroidism, * absence of hypogonadism, * absence of dialysis, * absence of thrombotic microangiopathy, * absence of macrophage activation syndrome, * no other known causes of poor graft function. * written informed consent must be obtained before any study-trial specific procedure are performed, * affiliation to a social security system. exclusion criteria: * criteria for poor graft function not fulfilled (see above), * patients aged less than 6 years old (or unable to swallow), * hepatic impairment (child-pugh ≥ 5), * patients with bone morrow fibrosis, * patients with a cytogenetic abnormality of chromosome 7 * hypersensitivity to eltrombopag or to any of the excipients, * patients with any contra-indication to eltrombopag, filgrastim, * unable to understand the investigational nature of the study or give informed consent, * history of congestive heart failure, arrhythmia requiring chronic treatment, arterial or venous, * thrombosis (not excluding line thrombosis) within the last 1 year, or myocardial infarction within 3 months before enrollment, * ecog performance status of 3 or greater, * pregnant and/or lactating women, * freedom privacy.

Keywords: poor graft function (pgf), allogeneic hematopoietic cell transplantation (allo-hct) eltrombopag.
data collection for next generation ultrasound technology development

Conditions: Endstage Renal Disease

Summary: the study is designed to collect data from a ultrasound device being used to evaluate feasibility of next generation algorithms for ultrasound data processing and does not test any health outcome.

the study is designed to collect data from a ultrasound device being used to evaluate feasibility of next generation algorithms for ultrasound data processing and does not test any health outcome. all eligible adults (aged 18 or older) will contribute case data from a convenience sample of maintenance hemodialysis population available at the study site and consistent with feasibility assessment of the technology. a relatively large feasibility population is used due to the need to test feasibility of multiple features across variations within this population.

Eligibility criteria:
inclusion criteria: 1. are adults (aged 18 years of age or older) at the time of consent; 2. are undergoing maintenance hemodialysis (mhd); and 3. are able and willing to provide written informed consent for participation exclusion criteria: 1. have anatomical characteristics or comorbid medical conditions that prevent completion of ultrasound scanning using the study device; or 2. are potentially put at additional risk by participating, in the opinion of the investigator.
comparative study of robotic, laparoscopic and open surgery for enucleation of benign pancreatic neoplasms

Conditions: Pancreatic Neuroendocrine Tumors

Summary: to determine the efficacy and safety of robotic, laparoscopic and open surgery for enucleation of benign pancreatic neuroendocrine tumors

the study was prospective and retrospective, non-randomized study included patients with benign pancreatic neoplasms. the robotic arm consecutively includes patients underwent robotic enucleation surgery and expected number in this arm is 50. the laparoscopic and open surgery arms retrospectively include case from the year 2004. the number of patients for laparoscopic and open surgery arms are 50 and 100, respectively.

Eligibility criteria:
inclusion criteria: * 18-80 years old * body mass index\<30 * preoperative diagnosis of resectable benign pancreatic neuroendocrine tumors * tumor type: non-functional pancreatic endocrine tumours and insulinomas * largest diameter \< 4cm * preoperative ct showed no evidence that tumor was connected with main pancreatic duct exclusion criteria: * severe cardio/pulmonary complications * other pancreatic diseases, including pancreatitis and pancreatic cancer * multiple pancreatic neuroendocrine tumors * distant metastasis
one-year patency comparison between radial artery and no-touch saphenous vein grafts in women undergoing isolated cabg

Conditions: Cardiac Disease; Surgery-Complications; Graft Failure

Summary: the use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. however, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. the saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. this randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.


Eligibility criteria:
inclusion criteria: women aged 18 years or older and younger than 70 years, undergoing isolated and primary myocardial revascularization surgery, with triarterial coronary artery disease (three vessels involved) in vessels subject to surgical revascularization and left ventricular ejection fraction greater than 35%. the target coronary vessels of the study will be those in the territory of the left circumflex artery and the right coronary artery, which must have at least 1.5 mm in diameter, and with proximal obstructive lesions of at least 70%. exclusion criteria: 1. preoperative conditions: 1. lack of the patient's written informed consent. 2. presence of poorly controlled diabetes, with a glycated hemoglobin value \>7 mg/dl. 3. emergency or salvage surgery, where the intervention needs to be performed quickly due to the critical clinical condition of the patient. 4. renal failure with glomerular filtration rate (creatinine clearance) \<30 ml/min. 2. inability to use the saphenous and/or radial vein 1. positive allen test using a pulse oximeter 2. presence of abnormal flow detected by means of a doppler exam in one of the grafts to be used. 3. history of vasculitis or raynaud's syndrome, varicose veins, or history of previous saphenous vein removal 3. conditions that may affect patient follow-up 1. presence of advanced peripheral arterial disease 2. known contrast allergy: presence of a documented allergy to the contrast agent used in radiological procedures. 3. impossibility of tracking due to geographic inaccessibility. 4. patients with lack of adherence to guidelines and/or prescribed medications.

Keywords: cardiovascular surgery coronary disease women graft patency
an observational study of avastin (bevacizumab) and interferon alpha 2a in patients with metastatic renal cell cancer (vera)

Conditions: Renal Cell Cancer

Summary: this prospective observational study will evaluate the efficacy and safety of avastin (bevacizumab) in combination with interferon alpha 2a in patients with previously untreated metastatic renal cell cancer. data will be collected from each patient for up to 4 years.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * histologically confirmed metastatic renal cell cancer, clear cell type * eligible for treatment with avastin and interferon alpha 2a according to local prescribing information exclusion criteria: * contraindications for avastin or interferon alpha 2a treatment according to local summary of product characteristics * known hypersensitivity to avastin and/or interferon alpha 2a or any of its excipients
honest, open, proud - college for post-secondary students with mental health challenges

Conditions: Stigmatization; Mental Health Issue; Disclosure

Summary: the purpose of the study is to evaluate the efficacy of an online format of the group-based intervention "honest open proud-college" among canadian post-secondary students.

mental health issues have been highlighted as a growing concern within the post-secondary student population. studies show that one significant concern for post-secondary students pertains to disclosing their mental challenges to others. disclosure decisions are especially relevant for postsecondary students in the context of academic and social support. students with mental health challenges who do not receive helpful accommodations may experience greater stress related to academics. students also note that, in navigating their social sphere, they often need to consider what aspects of their mental health challenges to share in what situations. as such, students often need to make decisions about whether to conceal or disclose their mental health challenges, both of which have their own pros and cons. disclosure is a complex decision that requires consideration of personal and contextual factors. honest, open, proud-college (hop-c) is a peer-led, group-based intervention, that supports post-secondary students in the process of making decisions to disclose their mental health conditions. this study will evaluate the impacts of hop-c administered through a videoconferencing platform on personal, social, and disclosure related outcomes.

Eligibility criteria:
inclusion criteria: * age 17 to 29 years old * enrolment in an university or college in canada * self-identify as experiencing mental health challenges * moderate level of self-reported self-stigma (score 4 or higher on the screening item "do you feel ashamed about dealing with anxiety, depression, or any other mental health challenges?", rated from 1, not at all, to 7, very much) exclusion criteria: -

Keywords: mental illness stigma self-stigma post-secondary students group intervention disclosure
five-year mortality rate in people with diabetic foot ulcer

Conditions: Diabetes Mellitus; Diabetic Foot; Diabetes Complications

Summary: as the global mortality rate decreases for diabetics patients, further explorations and datas are needed about the specific population of diabetics patients suffering a diabetic foot ulcer (dfu). this study investigates the 5 years mortality rate in patients with a diabetic foot ulcer occurring in 2010.

diabetic foot ulcer (dfu) is an economic burden for many countries around the world. it also induces a dramatic decrease in physical, emotional, and social functioning for patients. oftenly associated with advanced micro and macrovascular complications, high morbidity and a greater risk of premature death (mainly by ischemic heart disease) occure. only few studies explored dfu patients' long term survival: the few datas coming from cohorts in the 2000's reported mortality rates around 45% at five years after dfu's diagnosis. but life expectancy in diabetics patients imporved during last decade. so the main objective of our study is to evaluate the diabetics patients' 5 years mortality rate, in whom dfu was diagnosed in 2010. moreover, our secondary objective is to identify the mortality's predictive factors in 2010.

Eligibility criteria:
inclusion criteria: * type 1 or 2 diabetes * consultation for new diabetic foot ulcer during the year 2010 exclusion criteria: none

Keywords: diabetes mellitus diabetic foot mortality rate diabetes complications
the effects of bobath method and task-oriented approach in stroke patients

Conditions: Stroke

Summary: trunk impairment and asymmetry that occur after stroke negatively affect many functional activities in the daily lives of patients. there are different neurophysiological approaches such as bobath method and task-oriented approach used in post-stroke rehabilitation programs in the literature. however, there are not many studies that comprehensively evaluate and compare the effects of these neurophysiological approaches on trunk muscles, balance and gait in stroke patients. the aim of this study is to examine and compare the effects of bobath method and task-oriented approach on architectural features and activation of trunk muscles and functional performance in stroke patients. in addition, this study will demonstrate with muscle thickness and activation the asymmetry that may occur between the hemiparetic and non-paretic trunk muscles of stroke patients, and will allow examining the effects of these features on functional performance. this study was planned to include two treatment groups. the bobath group will receive bobath based trunk, balance and walking exercises, while the task-oriented group will receive exercises for oriented task. trunk impairment, motor functions, thickness and activation of trunk muscles, spatio-temporal parameters of gait, balance and goal attainment will be assessed before and after 8 weeks treatment program. as a result; effectiveness of bobath method and task-oriented approach will be compared and relationship between muscle thickness, activation and functional performance will be examined.


Eligibility criteria:
inclusion criteria: * unilateral stroke for more than 3 months * being over the age of 18 * having trunk impairment (not having full points in the trunk impairment scale) * being able to walk without support or with walking aid. exclusion criteria: * having recurrent stroke * having an orthopedic or neurological disorders other than stroke that may affect motor performance * having a cognitive problem (not having mini mental state examination score ≥ 24)

Keywords: stroke cerebrovascular disorders trunk muscle thickness ultrasonography muscle activation electromyography gait balance
a comparison of three different entry points to establish the pneumoperitoneum

Conditions: Laparoscopic Entry Technique

Summary: the palmer's point and periumbilical region are the common laparoscopic entry site to establish the pneumoperitoneum. in the present study, the investigators assess the safety and feasibility of meng's point as a new laparoscopic entry site in cases to perform the gastrointestinal surgery. this prospective and randomized study will compare the three entry techniques with regard to: * complications related to the entry technique * time taken to enter the abdomen. * the number of attempts taken to enter the abdomen

patients of china-japan friendship hospital that are having a laparoscopic surgery for general surgery purposes will participate in the study. patients with previous abdominal surgeries will be excluded from the study. a patient information sheet will be provided and written consent will be obtained. patients who give written consent will be randomized into the three arms of the trial. all patient information will be confidential and only be available to researches involved in the study. only one attending surgeon of the general surgery department of china-japan friendship hospital will participate in the study. 90 patients will be recruited over one year period and the data will be analysed by a statistician.

Eligibility criteria:
inclusion criteria: * any patient suitable for laparoscopic abdominal surgery exclusion criteria: * previous abdominal surgeries

Keywords: laparoscopic entry meng's point veress needle
perioperative stress management in outpatient surgery with l-tyrosine supplementation (spot)

Conditions: Stress

Summary: patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. the previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and l-tyrosine supplementation. currently with the progression of outpatient surgery and the need for early rehabilitation, l-tyrosine supplementation is suppressed to improve recovery. some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). the strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.


Eligibility criteria:
inclusion criteria: * membership of a social security scheme or equivalent * at least 18 years of age * able to express consent * indication of unilateral or bilateral inguinal hernia cure * general anaesthesia proposed and retained for inguinal hernia treatment regardless of surgical technique exclusion criteria: * surgical indication for another reason or hernial cure associated with another procedure * smoking estimated at more than 35 pack-years * history of psychiatric pathology * asa 3 or 4 according to the american society of anesthesiologists classification. as a reminder, an asa 3 class concerns a patient with a severe but not disabling general disease, and an asa 4 class concerns a patient with a disabling general disease involving the vital prognosis. * asa 2 and having at least one of the following pathologies or patients treated with -blockers: insulin-dependent diabetes, high blood pressure, heart rhythm disorder, dysthyroidism, progressive neurological disease, long-term benzodiazepines. * starch allergy or intolerance

Keywords: l-tyrosine supplementation perioperative stress
2d and tissue doppler imaging echocardiography analysis of left ventricular regional wall motion and prognosis

Conditions: Coronary Artery Disease

Summary: development of myocardial ischemia, and/or myocarditis would induce different changes in myocardial contraction behavior pattern,which maybe very subtle, and may not be detected by the 2d and m-mode echocardiography examinations. according to tissue doppler imaging(tdi), they can be depicted by different models of echo with higher frame rates. in addition, many studies using tdi have significantly contributed of efforts to evaluate systolic and diastolic function and prognosis. this study assess the value of the indices of left ventricular function obtained by using tdi in patient with coronary artery disease(cad). we hypothesized that tdi will add incremental value for regional wall motion abnormality of cad and its prognosis.


Eligibility criteria:
inclusion criteria: 1. angina 2. acue coronary syndrome 3. left ventricular systolic dysfunction exclusion criteria: 1. significant valvular disease 2. active cancer status 3. acute renal failure 4. contrast allergy history 5. pregnancy

Keywords: cad