Kornimate/medical-research-clean huggingface dataset:
the role of aquatic-based plyometric exercises for patients with juvenile idiopathic arthritis

Conditions: Juvenile Idiopathic Arthritis

Summary: this study was designed to assess the effect of a 12-week aqua-plyometric (aquaplyo) training on muscle strength, bone health, and physical ability in children with juvenile idiopathic arthritis (jia). forty-eight patients with jia were randomly allocated to the aquaplyo group (n = 24, received an aquatic-based plyometric training program, twice/week, over 12 weeks) or the control group (n = 24, received standard exercise program). both groups were assessed for muscle strength, bone health, and physical ability pre and post-treatment.

forty-eight patients with jia were recruited from the pediatric rheumatology clinics of three large referral hospitals in riyadh, saudi arabia. the study included patients who had a confirmed diagnosis of polyarticular jia (according to the criteria set forth by the international league of associations for rheumatology), aged 12-18 years, identified being stable cases, and did not participate in a regular exercise program (in the past six months). patients who had fixed deformities, a history of joint surgery, or whose radiological investigations revealed erosive changes of bone, ankylosing, or fractures were excluded. outcome measures 1. muscle strength: the peak concentric torque of the right and left quadriceps muscle was measured through an isokinetic dynamometer. 2. bone health: areal bone mineral density, volumetric bone density, and bone mineral content of the lumbar spine and neck of femur were measured through dual-energy x-ray absorptiometry (dexa) scanning. 3. physical ability: the physical performance was assessed using the 6-minute walk test. the aquaplyo group received a 12-week aquaplyo training, 45 minutes per session, two times a week for 12 consecutive weeks, in conformity with the national strength and conditioning association guidelines and american academy of pediatrics safety standards. the aquaplyo program consisted of ten unilateral and bilateral lower limb plyometrics in the form of hopping/bounding/jumping activities conducted in a water medium. the aquaplyo training included a warm-up for 10 minutes and a cool-down for 5 minutes. the control group received the standard exercise program, 45 minutes per session, two times a week for 12 consecutive weeks. the program consisted of flexibility exercise, strength training, weight-bearing, proprioceptive training, and free treadmill walking or cycle ergometry.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of jia * polyarticular onset of jia with bilateral involvement of the knee joint * age between 12 and 18 years * stable conditions (i.e., receive stable doses of medications in the past three months) * not participating in a regular exercise program in the past six months exclusion criteria: * fixed deformities * history of joint surgery * ankylosing or fractures * bone destruction (erosive changes of the knee joint) * cardiopulmonary comorbidities * recommendation against engaging in potentially explosive physical activities by the attending rheumatologist.
bowel dysfunction after rectal cancer treatment

Conditions: Low Anterior Resection Syndrome

Summary: bowel dysfunction after rectal cancer treatment may significantly affect the quality of life. our study aimed to estimate the incidence and characterize the low anterior resection syndrome(lars). we performed a prospective evaluation of patients treated with anterior resection for rectal cancer at two hospitals. assessment was performed at baseline, after neoadjuvant treatment, and 1, 6 and 12 months after bowel transit reconstruction using the following scores: bristol scale, lars score, msk-bfi, fiql, eortc-qlq30 and a visual analogue scale.

low anterior resection syndrome (lars) refers to wide-ranging symptoms including evacuatory dysfunction, fecal urgency and incontinence. the assessment of bowel dysfunction after rectal cancer treatment has improved since the development of the lars score. this score has widely been used with a meta-analysis reporting a pooled prevalence of "major lars" of 41%. however, several studies have found a large proportion of patients with major lars in the general population without rectal cancer raising questions about the specificity of this score. moreover, most studies on the prevalence of lars do not include a baseline evaluation and, therefore, may not allow establishing whether the dysfunctions appeared after the treatment. consequently, we considered that a prospective study including a baseline evaluation and multiple validated questionnaires was required. the present study aimed to estimate the incidence and characterize bowel dysfunction after rectal cancer treatment. the results of this study will be useful to improve the preoperative information given to the patient and the shared decision-making process.

Eligibility criteria:
inclusion criteria: patients with anterior resection for rectal adenocarcinoma with curative intention, with or without neoadjuvant chemoradiotherapy, total or partial excision of the mesorectum, colorectal or coloanal anastomosis. exclusion criteria: * disseminated disease * surgery with palliative intent * refusal to participate in the study * intellectual difficulty to answer the questionnaires
evaluation of one burr hole evacuation for subdural hematoma

Conditions: Subdural Hematoma

Summary: to evaluate the outcome of one burrhole evacuation for subdural hematoma and it has the same result of traditional two burrhole

* subdural hematoma (sdh): abnormal collection of liquefied blood degradation underneath the dura matter (1.2.3). * one of the most frequent types of intracranial haemorrhage, that is still associated with significant morbidity (1.4.5). * the sdh: is a common disease in elderly patient, and its incidence is highest in persons older than 70 years of age (1.5). * types of subdural hematoma(18.19) 1- acute: present within 48-72 hours of injury. 2. sub-acute: manifest itself between 3-20 day. 3- chronic (ch): produce symptoms from 3 weeks to several months after injury risk factors: (7.8.9.10.11.12) 1. trauma; mostly minor trauma, approximately two thirds of the patients have suffered one. reports exist of chronic sdh due to birth trauma in neonates. 2. advanced age: the elderly are at risk due to: 1. brain atrophy, whereby the bridging veins are stretched and become more fragile. 2. older people tend to fall more often and suffer minor head trauma. 3. with increase age, the incidence of blood thinner administration raises leading to increased risk for haemorrhage 3. chronic alcoholism: 4. gender: men, from all age groups, suffer higher rates of chsdh than woman. 5. coagulapathy: therapeutic anticoagulation and antiplatelet therapy. 6. medical conditions: sepsis, hepatic failure, hemophilia, dic and renal dialysis. 7. intracranial hypotension: as after ventriculoperitoneal shunt. clinical presentation (1.13) * symptoms of increase intra cranial pressure: headache, nausea, vomiting. * focal neurological deficit - (weakness, aphasia). * disturbed conscious level (dcl) * seizures * imaging investigation: ct brain (14.15) * management : (1.6.16.17) 1. conservative: a watch, wait and re-scan policy is usually recommended in asymptomatic or minimally symptomatic patient with a thin chsdh. 2. surgical: for symptomatic (sdh) a- burr hole drainage b-twist drill drainage c- craniotomy * prognostic factors : (2.5) 1- age of patient 2- associated chronic diseases like hypertension, liver diseases .......etc 3- laboratory investigation like hb , platlate count ,pc,and pt. 5- hematoma thickness 6- number of burr hole : one or two burr hole

Eligibility criteria:
inclusion criteria: * patients with subdural hematoma either unilateral or bilateral * fit for surgery * chronic sdh * subacute sdh * age: patients older than 18 years old * sex: both sex exclusion criteria: * patients unfit for surgery * acute sdh * subdural hyroma * subdural empyema * patient treated conservatively
canadian study of trandolapril on blood pressure in hypertensive patients (trail)

Conditions: Hypertension

Summary: the trail study was conducted to examine the effects of escalating doses of an ace inhibitor, trandolapril, on lowering blood pressure in stage 1-2 hypertensive patients.


Eligibility criteria:
inclusion criteria: * stage 1 or 2 hypertension exclusion criteria: * uncontrolled diabetes * subject has a hypersensitivity to ace inhibitor

Keywords: hypertension trandolapril
visual function after implantation of bilateral acrysof restor aspheric +3

Conditions: Cataract

Summary: a prospective evaluation of the visual parameters in a series of patients bilaterally implanted with acrysof restor +3 intraocular lens (iol).


Eligibility criteria:
inclusion criteria: * diagnosed with cataracts exclusion criteria: * pre-existing conditions that could skew the results or are contraindications for the restor intraocular lens; * \<1 diopter astigmatism by keratometry readings.

Keywords: restor aspheric +3 iol
a randomized controlled trial of apps to home monitor your asthma

Conditions: Asthma

Summary: the objective of this study is to design, implement, and evaluate the impact of an adapted health information technology(it)-enabled practice model for asthma symptom monitoring using patient-reported outcomes (pros) in a primary care setting. adults over 18 years of age with asthma will be recruited at primary care clinics and randomized to either 1) asthma symptom monitoring via the mobile health (mhealth) app; or 2) usual care. the investigators will collect data on patient-reported asthma quality of life and asthma-related healthcare utilization. we will also study barriers and facilitators to implementation of the mhealth app and health it-enabled practice model.

the specific aims of this study are: 1. adapt our existing health it-enabled practice model for asthma symptom monitoring using pros to a primary care population. the health it-enabled practice model is comprised of the following: an mhealth app that can be installed on patients' smartphones that integrates into clinical workflow; and an asthma pro dashboard in the electronic health record (ehr) for clinicians. 2. implement the adapted health it-enabled practice model in 7 primary care community clinics, identify a cohort of eligible asthma patients to participate, and train clinicians and clinical staff. 3. rigorously evaluate the impact of this new health it-enabled practice model using a randomized controlled trial study in which we enroll 500 asthma patients (250 intervention, 250 usual care) by primary care clinician. we will measure patient-reported asthma quality of life and asthma-related healthcare utilization (defined as urgent care and emergency room visits and hospitalizations) as our primary and secondary outcomes, respectively. we will use mixed methods to identify barriers and facilitators to implementation and factors that affect sustainable spread and scale as per the non-adoption, abandonment, scale-up, spread, and sustainability (nasss) framework.

Eligibility criteria:
inclusion criteria: * english- or spanish-speaking * 18 years of age * regularly uses (most days) a compatible smartphone (ios or android) * able to provide consent * seen for primary care within the last 12 months at one of the 7 outpatient primary care clinics that are part of the brigham \& women's hospital (bwh)/ brigham \& women's faulkner hospital (bwfh) practice-based research network. * at least one visit coded for asthma within 12 months prior to screening, including inpatient, emergency department, urgent care/walk-in, and specialist visits. exclusion criteria: * deemed inappropriate for study, per judgment of the bwh/ bwfh primary care provider * unable to provide consent

Keywords: patient-reported outcomes (pros) mobile health (mhealth) apps asthma electronic health record (ehr) health information technology implementation research mobile phone
study to assess the burden of mild outcomes (physician office visits) due to influenza in the united states

Conditions: Influenza

Summary: this is a database study to quantify the burden of multiple mild outcomes (i.e., those that result in visits to a physician's office) attributable to influenza in the united states, stratified by age group, geographic region and influenza subtype for selected influenza seasons.

this is a retrospective database study to quantify the burden of multiple mild pre-defined influenza-attributable outcomes of interest, which resulted in physician office visits for persons who were less than 65 years of age, in the united states in the relevant marketscan commercial database in the period from july 2000 through april 2009, and october 2010 to may 2011. the corresponding physician office visits for persons 65 years of age and older, with a mild influenza-attributable outcome of interest, in the united states that were recorded in the relevant marketscan medicare supplemental database in the period from july 2006 through april 2009, and october 2010 to may 2011 were also investigated. the period from april 2009 through september 2010 is excluded to avoid the h1n1 pandemic wave.

Eligibility criteria:
inclusion criteria: • recorded in a marketscan database with any of the specified diagnostic codes. exclusion criteria: • missing data in any of the following fields: age, diagnosis, region or visit date.

Keywords: mild outcomes database influenza-attributable retrospective influenza united states of america (usa)
the influence of nocturnal food intake in eating behavior of night workers

Conditions: Shift Work Type Circadian Rhythm Sleep Disorder

Summary: this study aimed to verify the influence of night work and food intake during the night shift on the eating behavior of fixed night workers the next day.

night work causes restriction of sleep time and circadian misalignment and, therefore, have been associated with nutritional and metabolic impairments. the objective of the present study is to verify the influence of night work and food intake in this period on the behavior of the following day. the workers selected by criteria and inclusion and exclusion will be evaluated at the baseline: anthropometric parameters, food consumption and perception, duration of food consumption, sleep habits and chronobiological pattern (sleep monitoring by actigraphy, chronotype, social jet lag), parameters biochemical (blood count, lipidogram, c-reactive protein, cortisol, glucose, insulin).subsequently, 30 workers will integrate a randomized and controlled crossover clinical study with three randomly established interventions: (1) two nights of work without meals during the shift; (2) two nights of work with a meal during the shift; (3) two nights sleep. participants will go to the laboratory the morning after the second night of each condition to offer a test meal ad libitum, which will consist of foods of various compositions and food groups. preprandial metabolic assessments will be conducted (ghrelin, glp-1 - glucagon-like peptide 1, pyy-peptide yy). the following postprandial evaluations will be carried out and in the 24 hours following the experiment: food choices (record of all foods) and food perceptions (hunger, appetite, satiety and eating). it is expected to determine how nocturnal versus nocturnal work, and nocturnal fasting versus nocturnal fasting affect the next day's food choices.

Eligibility criteria:
inclusion criteria: * agree to participate in the study and sign the informed consent form (ehic). * no significant changes in body mass in the last 6 months. * with stable food and sleep routine in the last two months. exclusion criteria: * failure to provide the information or material necessary for the development of the study. * report of chronic non-communicable diseases. * report of diagnosed and untreated psychiatric disorders.
effectiveness of probiotic gummies in relieving allergic rhinitis in children

Conditions: Children With Allergic Rhinitis

Summary: to evaluate the effect of probiotic gummies on serum metabolite levels, clinical efficacy, and regulation of gut microbiota in children with allergic rhinitis compared with placebo.


Eligibility criteria:
inclusion criteria: 1. voluntary, written, signed informed consent to participate in this study; 2. be able to complete the study in accordance with the requirements of the test protocol; 3. age 4-14 years old; 4. meet the diagnostic criteria for allergic rhinitis established in the guidelines for the diagnosis and treatment of allergic rhinitis in children (2022 revised edition); 5. symptoms: 2 or more symptoms: sneezing, watery discharge, nasal itching and nasal congestion and other symptoms last or accumulate for more than 1 hour per day, and may be accompanied by eye symptoms such as itching, watery eyes and red eyes; 6. signs: pale and edema of the nasal mucosa, which may be accompanied by watery discharge; exclusion criteria: 1. drugs that affect the intestinal flora (including antimicrobial drugs, microecological preparations, intestinal mucosal protectors, chinese patent medicines, etc.) have been used continuously for more than 1 week within 1 month before screening; 2. patients with pulmonary tuberculosis; 3. combined with allergic asthma; 4. those with nasal polyps or severe nasal septum deviation; 5. patients with severe systemic diseases or malignant tumors; 6. those with congenital genetic diseases and congenital immunodeficiency diseases; 7. those who regularly use probiotics or prebiotics within 6 months before the screening period; 8. those with severe digestive tract diseases (including severe diarrhea, inflammatory bowel disease, etc.); 9. patients with metabolic syndrome (including obesity, dyslipidemia, hypertension, diabetes, etc.); 10. patients with sinusitis, otitis media, or respiratory tract infection; 11. those who are allergic to the probiotic-related ingredients used in this trial; 12. those who stop taking the test sample or add other drugs in the middle of the test, and the efficacy cannot be judged or the data is incomplete; 13. those who take items with similar functions to the test in a short period of time, which affects the judgment of the results; 14. subjects who are unable to participate in the test due to their own reasons; 15. subjects who are judged by other investigators to be insuitable to participate.
time to treatment and disease-free survival of patients with high-risk head-neck cutaneous squamous cell carcinoma

Conditions: Carcinoma, Squamous Cell; Skin Cancer; Carcinoma, Squamous Cell, Skin; Carcinoma, Squamous Cell of Head and Neck; Recurrence; Metastasis

Summary: the purpose of this study is to investigate the association between time to treatment (defined as date of pathological diagnosis to date of start treatment) and disease free survival in patients with high risk cutaneous squamous cell carcinoma in the head-neck region.

skin cancer is the most common type of cancer in the netherlands. cutaneous squamous cell carcinoma (cscc) accounts for 20% of all cutaneous malignancies. the incidence of cscc has been rising over the years in the netherlands, from 8,966 new csccs cases registered in 2012 to 14,873 cases in 2022. csccs mostly involve patients aged 75 years and older. since exposure to uv radiation is the main risk factor for the development, csccs particularly occur on sun exposed areas of the skin such as in the head-neck region and the extremities. other risk factors include a fitzpatrick skin type i or ii, use of immunosuppression, exposure to arsenic, and infection with human papilloma virus. risk of metastasis and recurrence in general csccs are 2.6-5% and 1.9-3.7%, respectively. however, these risk ratios may increase to 37% in high-risk csccs. high risk csccs are defined as csccs with risk factors for development of metastatic disease or recurrence, e.g. poor histological differentiation, perineural/lymphovascular infiltration, diameter ≥20 mm. due to the increasing incidence, advanced age, risk of metastasis and recurrence, and the high risk-location in the head-neck region related to functional and cosmetic importance, high-risk csccs in the head-neck region (high-risk hncsccs) require complex and multidisciplinary care. therefore, care pathways have been developed. an important part of these care pathways are waiting times and, in particular, the time to treatment. for example, in mucosal head-neck tumors, prolonged waiting times have been described to be associated with reduced survival rates. this led to the hypothesis that prolonged waiting times result result in lower survival rates for patients with high-risk hncsccs. this study aimed to investigate the association between time to treatment defined as date of pathological diagnosis to date of start treatment) and disease free survival in patients with high risk hncsccs.

Eligibility criteria:
inclusion criteria: * patient diagnosed with high-risk hncsccs, defined as t2 to t4 hncscc * treated in the maastricht university medical center+ (mumc+) or radboud university medical center (radboudumc) * treated between 2010 to 2018 exclusion criteria: * patients aged younger than 18 years * patients with a t1 hncscc * patients with recurrence or metastatic disease of a previously treated hncscc

Keywords: disease free survival survival multicenter time to treatment waiting times
kaffes stent in the management of post-surgical biliary strictures

Conditions: Benign Biliary Stricture; Biliary Stricture; Cholangitis; Bile Duct Stricture; Bile Duct Injury

Summary: post-surgical biliary strictures are common especially after cholecystectomy. standard treatment involves the performance of multiple procedures over a 1 year period at least using several plastic stents to achieve permanent dilatation of these strictures. metallic stents have the theoretical benefit of absence of need of multiple sessions. these strictures however are frequently very close to the hilum and thus previously considered a contraindication for insertion of metallic stents for the fear of occlusion of the contralateral ducts. metallic stent migration is also a frequent problem. the use of a metallic stent that is short and completely intraductal, in theory, should reduce the risk of stent migration. this is a randomized controlled trial comparing the efficacy and safety of a short metallic intraductal stent to the conventional treatment which is multiple plastic stents. in cases with a stricture reaching or close to the hilum a technique is used to avoid obstruction of the contralateral ducts which is insertion of a 7 french plastic stent alongside the metallic stent.


Eligibility criteria:
inclusion criteria: * confirmed benign postsurgical biliary stricture by presence of all 3 of the following: ultrasound imaging or magnetic resonance cholangiopancreatography (mrcp) showing biliary dilatation, raised bilirubin and or alkaline phosphatase, history of biliary tree surgery within the previous year * naïve to endoscopic therapy * age \> 18 years exclusion criteria: * coagulopathy * inability of patient to adhere to regular follow-up * living-donor liver transplant patients