Kornimate/medical-research-clean huggingface dataset:
sintilimab combined with chemotherapy as adjuvant treatment for phase iii gc and gej

Conditions: Gastric Adenocarcinoma; Esophagogastric Junction Adenocarcinoma

Summary: this study is a prospective, single-arm, phase ii clinical study. screening patients with stage iii gc/gej adenocarcinoma after d2 or broader radical resection. after enrolling in the study, the subjects receive sintilimab combined with oxaliplatin+tegafur, gimeracil and oteracil potassium capsules (sox) or oxaliplatin+capecitabine (xelox) , in which the combined chemotherapy is up to 8 cycles, and the total course of treatment was 16 cycles. the following-up of subjects includes adverse events、disease status、living conditions and the quality of life.

this study is a prospective, single-arm, phase ii clinical study. screening patients with stage iii gc/gej adenocarcinoma after d2 or broader radical resection that meets the criteria for group entry and does not meet the exclusion criteria. after signing the informed consent, the subjects entered the trial group to receive adjuvant treatment with sintilimab combined with chemotherapy (sox or xelox ), in which sox or xelox chemotherapy was up to 8 cycles, and the total course of treatment was 16 cycles. the efficacy is evaluated every 4 cycles during the study treatment. the frequency of follow-up after treatment is defined as: once every 3 months within 2 years after surgery, every 6 months for 2 to 5 years, and once a year after 5 years. the follow-up interval can be adjusted according to the clinical need. safety follow-up is from the beginning of the first treatment to 30 days after the last medication.

Eligibility criteria:
inclusion criteria: 1. age ≥18. 2. patients with histopathological confirmed gastric/gej adenocarcinoma. 3. the ptnm is confirmed between iiia-iiic and the pd-l1 cps\>=1. 4. patients treated with d2 surgery. 5. ecog is 0 or 1. 6. patients who could tolerate chemotherapy combined with immunotherapy. 7. patients who are not pregnant and have no willing to get pregnant within 6 months after the treatment is over. 8. patients who are willing to offer their postoperative tumor tissue and their peripheral blood samples. 9. patients who are volunteer to sign the icf. exclusion criteria: 1. patients who had received neoadjuvent treatments before surgery. 2. patients who have discovered tumor relapse or metastasis before adjuvent treatment. 3. patients who have other malignant tumors. 4. patients who could not swallow the tablets and capsules. 5. other conditions which the researchers think are not suitable for participate the study.
switch study to evaluate f/taf in hiv-1 infected adults who are virologically suppressed on regimens containing abc/3tc

Conditions: HIV-1 Infection

Summary: the primary objectives of this study are to evaluate the efficacy, safety, and tolerability of switching abacavir/lamivudine (abc/3tc) fixed-dose combination (fdc) tablets to emtricitabine/tenofovir alafenamide (f/taf) fdc tablets versus maintaining abc/3tc in human immunodeficiency virus type 1 (hiv-1) infected adults who are virologically suppressed on regimens containing abc/3tc.


Eligibility criteria:
key inclusion criteria: * the ability to understand and sign a written informed consent form * on antiretroviral regimen containing abc/3tc fdc in combination with one 3rd agent for ≥ 6 consecutive months prior to screening * plasma hiv-1 rna levels \< 50 copies/ml for ≥ 6 months preceding the screening visit (measured at least twice using the same assay) and without experiencing two consecutive hiv-1 rna above detectable levels after achieving a confirmed (two consecutive) hiv-1 rna below detectable levels on the current regimen in the past year * plasma hiv-1 rna should be \< 50 copies/ml at the screening visit * normal ecg * estimated glomerular filtration rate (gfr) ≥ 50 ml/min according to the cockcroft gault formula for creatinine clearance * hepatic transaminases (ast and alt) ≤ 5 × upper limit of normal (uln) * total bilirubin ≤ 1.5 mg/dl, or normal direct bilirubin * adequate hematologic function * serum amylase ≤ 5 × uln * females of childbearing potential and males must agree to utilize highly effective contraception methods or be non-heterosexually active or practice sexual abstinence from screening throughout the duration of study treatment and for 30 days following the last dose of study drug key exclusion criteria: * a new aids-defining condition diagnosed within the 30 days prior to screening * hepatitis b surface antigen (hbsag) positive * individuals experiencing decompensated cirrhosis * individuals receiving ongoing treatment with bisphosphonate to treat bone disease (eg, osteoporosis) * pregnant or lactating females * have an implanted defibrillator or pacemaker * current alcohol or substance use judged by the investigator to potentially interfere with study compliance * a history of malignancy within the past 5 years (prior to screening) or ongoing malignancy other than cutaneous kaposi's sarcoma (ks), basal cell carcinoma, or resected, non-invasive cutaneous squamous carcinoma. * active, serious infections (other than hiv-1 infection) requiring parenteral antibiotic or antifungal therapy within 30 days prior to day 1 visit * any other clinical condition or prior therapy that, in the opinion of the investigator, would make the individual unsuitable for the study or unable to comply with dosing requirements * participation in any other clinical trial (including observational trials) without prior approval * medications excluded due to the potential for interaction with emtricitabine (ftc), taf, abc or 3tc note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: hiv hiv-1 positive virologically-suppressed
adenoma detection rate of 3d colonoscopy

Conditions: Colorectal Neoplasms; Colorectal Cancer

Summary: adenoma detection rate (adr) has been the most important quality indicator on colonoscopy because adr was reversely related with crc incidence and mortality. several image enhanced technologies, such as narrow-band imaging (nbi) or linked colour imaging (lci) had been proved to have ability to increase the adr. 3d techonology, however, has not been validated on colonoscopy performance. therefore, current study was to compare the adr between new 3d colonoscopy and conventional 2d colonoscopy.

an accumulating body of evidence has shown that detection and resection of pre-cancerous adenoma by colonoscopy could effectively prevent colorectal cancer (crc) and its related mortality. among various colonoscopy quality indicators, such as cecal intubation rate, withdrawal time, and adenoma detection rate (adr), adr is the most important one and most closely associated with the subsequent risk of crc. a recent study further demonstrated the improvement of adr could reduce subsequent risk of crc. to be noted, among all colorectal neoplasm, non-polypoid lesions, such as flat or depressed lesions, carries higher likelihood to be overlooked during conventional colonoscopy and these overlooked lesions were the main etiology of post-colonoscopy colorectal cancer (pccrc). nowadays, several colonoscopy technologies had been developed to enhance the detection of colorectal adenoma such as using digital or dye-spray chromoendoscopy or add-on device such as cap-assisted endoscopy. among them, some had showed the potential to enhance the detection of non-polypoid lesion, for example, the next-generation nbi or iscan. 3d endoscopy is a new technology that using image processing technique to offer more information on tissue depth in comparison with conventional 2d endoscopy. the utility of 3d endoscopy on gi tract was mainly from upper gi tract and it was proved to enhance the diagnostic accuracy on superficial gastric tumors and shortened the procedure time during performing gastric endoscopic submucosal dissection(esd). however, few is known that whether 3d colonoscopy could enhance the adenoma detection, especially for non-polypoid lesion detection, during colonoscopy examination. therefore, this prospective, randomized control study is aim to demonstrate the efficacy of 3d colonoscopy on adenoma detection in comparison with conventional 2d colonoscopy.

Eligibility criteria:
inclusion criteria: * age 40 or above * indication for colonoscopy, including screening, surveillance, symptomatic, etc exclusion criteria: * poor and inadequate bowel preparation * incomplete study because of obstructive lesion, including cancer, stenosis, etc. * failure of cecal intubation, difficult insertion * inflammatory bowel disease * hereditary polyposis, (fap, lynch syndrome, hyperplastic polyposis, etc.)

Keywords: 3d colonoscopy colorectal neoplasm
study comparing marathon polyethylene and enduron polyethylene acetabular liners used in total hip arthroplasty

Conditions: Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Summary: the purpose of the study is to determine whether crosslinked marathon and standard enduron polyethylene liners show differences in bone loss around the hip implant.

several institutions report very low wear rates with highly crosslinked polyethylene based on early clinical data. however, since bone loss typically appears after 5-year follow-up, the reduction in the incidence and extent of bone loss among total hip replacement patients with crosslinked marathon liners, compared to those with standard enduron liners, has not been as dramatic as the wear reduction. despite the substantial reduction in wear that we observed at 5-year follow-up, the patients' perceptions of their outcomes remained similar among the marathon and enduron groups. this study will evaluate outcome at a minimum of 10-years after surgery among the same group of patients whose outcome was previously reported at 5-year follow-up. at 10-year follow-up, we anticipate that the reduction in wear associated with marathon polyethylene will be associated with significant reductions in bone loss when compared to the enduron polyethylene.

Eligibility criteria:
inclusion criteria: (from original study) -elective total hip replacement patient (from 10-year follow-up) * consented to the original study. * received a duraloc 100 cup with either a crosslinked marathon or standard enduron liner. * received an aml/solution or a prodigy stem with 28mm cobalt chrome femoral head. exclusion criteria: (from original study) -none (from 10-year follow-up) * patient did not receive device as specified in inclusion criteria. * patient refused to consent to the 10-year follow-up.

Keywords: osteolysis polyethylene crosslinked polyethylene total hip replacement ct
chronic muscle disuse in the elderly

Conditions: Osteoarthritis

Summary: the purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly characterized by chronic muscle disuse (patients with knee osteoarthritis) and healthy elderly no evidence of knee osteoarthritis and normal physical activity levels.

skeletal muscle disuse is an important contributing factor to physical disability. disuse is more frequent in the elderly and they are more susceptible to its debilitating effects because of their diminished physiological reserve. despite these facts, the mechanisms whereby disuse promotes skeletal muscle contractile dysfunction in this population remain largely undetermined. therefore, the investigators will systematically test for modifications of single skeletal muscle fiber structure and function that underlie contractile dysfunction. elderly individuals characterized by chronic muscle disuse (patients with knee osteoarthritis) will be compared to carefully-matched controls with no clinical evidence of knee osteoarthritis and normal activity levels. thereafter, elderly with chronic disuse will undergo an exercise intervention to remediate muscle disuse. the investigators hypothesize that muscle disuse impairs contractile function, in part, through alterations in myosin kinetics, myofilament protein content and the mechanical properties of the myofilament lattice and that exercise rehabilitation will counteract these deficits. the investigators will specifically examine the effect of disuse on mechanical, kinetic and structural properties and molecular composition of single muscle fibers in cases and controls, as well as determine how increasing muscle use in elderly with chronic disuse via exercise training affects muscle fiber mechanical, kinetic and structural properties and molecular composition. these translational studies will provide the first comprehensive evaluation of the cellular and molecular mechanisms through which muscle disuse alters skeletal muscle structure and contractile function in elderly humans. this knowledge can assist in the development and refinement of preventative and corrective therapies for disability by tailoring these approaches to address specific molecular defects.

Eligibility criteria:
knee osteoarthritis patients inclusion criteria: * 60-80 yrs of age * physician-diagnosed, symptomatic knee osteoarthritis * ambulatory and able to perform lower extremity resistance exercise exclusion criteria: * rheumatoid arthritis or other autoimmune disease * chronic heart, lung, kidney or liver disease or hypertension * diabetes * history of stroke * other neurological or musculoskeletal disease healthy controls criteria are identical to those for knee osteoarthritis patients above, but controls will have no clinical or radiographic evidence of osteoarthritis and will have normal activity physical activity levels.

Keywords: elderly muscle disuse osteoarthritis exercise
the effect of virtual reality application on pain severity, anxiety level and patient satisfaction

Conditions: Anxiety; Pain

Summary: in this study; it is aimed to examine the effect of virtual reality based relaxation program on pain severity, anxiety level and patient satisfaction in patients who will be applied angiography.

beginning 1 minute before the start of the procedure, the patients will be watched (30-45 minutes) with an android mobile phone inserted into the cardboard super flex binoculars glasses, with a music background, licensed product "secret garden", during the procedure (30-45 minutes).

Eligibility criteria:
inclusion criteria: * being over 18 years old * ability to communicate adequately * absence of psychiatric problems * volunteering to participate in the research * experiencing coronary angiography for the first time exclusion criteria: * those who have communication problems * those with psychiatric problems * emergency coronary angiography * having symptoms of myocardial infarction, * being unconscious, * having surgery in the last 6 weeks,

Keywords: virtual reality glasses pain anxiety angiography.
arterial tone influence on cardiac output measured by pram

Conditions: Cardiac Output; Critically Ill

Summary: this study evaluates the role of arterial tone in the accuracy of cardiac output (co) measurement by pressure recording analytical method (pram). patients receiving noradrenaline who need for clinical reason to change the noradrenaline dose will be enrolled. we use echocardiography as reference method of co measurement.

pressure recording analytical method (pram) is an arterial pulse contour analysis method for co measurement. as it is an uncalibrated method, one possible reason for its inaccuracy is rapid changes in arterial tone.

Eligibility criteria:
inclusion criteria: * invasive blood pressure monitoring on site * need to start or change the dose of noradrenaline infusion for clinical reason exclusion criteria: * age \<18 * arrhythmia * severe valvular insufficiency * pregnancy * low quality arterial signal
quality of life after esophagectomy for cancer

Conditions: Esophageal Cancer

Summary: the purpose of the current study is to assess the role of pyloric drainage procedure on altering the reflux effect on the quality of life in patients who underwent esophagectomy. researchers hypothesize that the patients who underwent minimally invasive esophagectomies without pyloric drainage experience less reflux symptoms and therefore have a better quality of life.

surgery is considered curative for patients with esophageal cancer. the minimally invasive approach was developed such that laparoscopy and thoracoscopy replace large abdominal and thoracic incisions. for both open and minimally invasive procedures, patients have many adjustments to overcome in order to regain quality of life that is within the norm. in a recent study on the health-related quality of life (hrql) after curative surgical resection, symptoms of reflux was the only variable that worsened with statistical significance. the study plan is to retrospectively compare two groups of patients: those who underwent esophagectomy with pyloric drainage procedure and those who did not. the study will be done using all md anderson patients who underwent minimally invasive esophagectomies, in which pyloroplasty and pyloromyotomy are not standard procedures. clinically relevant data and demographic information will be collected retrospectively for the two groups including age, gender, body mass index, level of anastomosis, and time elapsed since surgery. all patients will be interviewed via telephone. at least two attempts will be made to contact each patient.

Eligibility criteria:
inclusion criteria: 1. patients who are 18 years-old or older 2. patients who received esophagectomy indicated for primary esophageal cancer, either adenocarcinoma or squamous cell carcinoma 3. patients who received minimally invasive or transthoracic or transhiatal or three-field esophagectomy at mdacc during or after 2004 4. patients who are english-speaking and of any ethnicity 5. patients with prior cancers, any clinical stage of esophageal carcinoma, any performance status (as rated by american society of anesthesiologist risk scale), received or did not receive preoperative treatment, had level of anastomosis in either neck or chest exclusion criteria: 1) patients who received esophagectomies indicated for emergency, salvage or redo

Keywords: esophageal cancer pyloric drainage pyloric drainage procedure reflux reflux symptoms esophagectomy quality of life health-related quality of life hrql
the fbri vtc neuromotor research clinic

Conditions: Neuromotor Impairments; Cerebral Palsy; Microcephaly; Autism; Trauma, Brain; Acquired Brain Injury; Pediatric Stroke

Summary: the fbri vtc neuromotor research clinic was established and opened in may of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. it is direct by dr. stephanie deluca and based on the principles surrounding acquirec therapy. acquirec therapy is an evidenced-based approach to pediatric constraint-induced movement therapy, which refers to a multi-component form of therapy that is focused on helping children who have asymmetric motor abilities between the two sides of the body. historically, acquirec therapy has the unimpaired or less impaired upper extremity constrained (by a cast or a splint) while also receiving active therapy from a specially trained therapist who shapes new skills and functional activities with the child's more impaired upper extremity but who is also a licensed occupational or physical therapist (ot/pt). therapy dosages are high much higher than tradition ot or pt - often lasting many hours per day, up to 6 hours a day, 5 days a week, for 2-4 weeks. investigators have developed further treatments based on the same principles of intensive services combined with behavior shaping for other areas of the body that are also affected by weakness (e.g., the leg and trunk) also, but which usually do not involve constraint. these have been more generally labeled acquire therapy. all forms involve intensive, play-based therapy for children with asymmetric motor impairments of the arms and hands. the primary focus of treatment is to facilitate the acquisition of new motor skills in the child's weaker body parts through high levels of intensive therapy using scientifically-based behavioral guidelines. therapy is also delivered in naturalistic environments. acquirec therapy as a treatment method has been tested in two randomized controlled trials, and a specific manual for its implementation has been developed. dr. (s) ramey and deluca previously founded a similar clinic, the pediatric neuromotor research clinic, at the university of alabama at birmingham where dr. deluca directed the research clinic for 13 years and oversaw the implementation of the acquirec therapy treatment protocol in more than 400 cases. this research will involve analyzing and interpreting the clinical data of children going through clinical procedures at the fbri vtc neuromotor research clinic. all participation is voluntary and no children will denied services if families choose not to participate.


Eligibility criteria:
inclusion criteria: * neuromotor impairment exclusion criteria: * fragile health
dietary oxalate and innate immunity in kidney stone disease

Conditions: Kidney Stone

Summary: this study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate).

oxalate is a small molecule found in plants and plant-derived food. it has been shown that meals containing high amounts of oxalate can increase urinary oxalate excretion, which is a risk factor for calcium oxalate kidney stones (caox ks). small increases in oxalate can stimulate urinary crystals to form which can elicit an immune response. this study consists of having healthy subjects consume both low and oxalate enriched diets to evaluate the effect of oxalate on urinary crystals and immune responses. participants will receive a low or high oxalate diet for 4 days prior to having a wash out period for 6 days. participants will then crossover to the opposite oxalate diet for four more days.

Eligibility criteria:
inclusion criteria: * healthy subjects (men and women) between the ages of 18 and 60 years of age * no calcium oxalate kidney stones or other medical conditions * normal comprehensive metabolic panel (cmp) * non tobacco users * not pregnant * bmi between 20-30 kg/m2 * willing to abstain from vigorous exercise and vitamins/supplements during the study * willing to consume only provided diets, accurately collect 24-hour urine samples, and have blood drawn exclusion criteria: * inability to sign and read the informed consent * any medical, psychiatric, or social conditions that would prohibit participants from abiding by the study requirements * physician refusal * pregnant women * active medical problems * history of kidney stones or any medical condition that could influence absorption or excretion of oxalate * tobacco users * taking medications or dietary supplements * bmi \>30 or \<20

Keywords: dietary oxalate diet therapy