Kornimate/medical-research-clean huggingface dataset:
non - incised papilla versus single flap technique in the reconstruction of intrabony defect

Conditions: Periodontal Attachment Loss

Summary: the present study will aim to assess the effectiveness of the non-incised papilla surgical approach nipsa used for the surgical debridement of deep intraosseous defects compared to the single-flap approach sfa. primary outcome: interproximal clinical attachment level gain secondary outcomes: residual probing pocket depth (ppd), pocket depth (pd) reduction, recession (rec), location of the tip of the papilla (tp), width of the keratinized tissue (kt), wound closure (wc), supra-alveolar attachment gain (supra-ag)

the present study will aim to assess the effectiveness of the non-incised papilla surgical approach nipsa used for the surgical debridement of deep intraosseous defects compared to the single-flap approach sfa. primary outcome: interproximal clinical attachment level gain secondary outcomes: residual probing pocket depth (ppd), pocket depth (pd) reduction, recession (rec), location of the tip of the papilla (tp), width of the keratinized tissue (kt), wound closure (wc), supra-alveolar attachment gain (supra-ag)

Eligibility criteria:
inclusion criteria: * - age \> 18 years * diagnosis with stage iii-iv periodontitis. * presence of one or more intrabony defects with probing pocket depth (ppd) \> 5 mm and radiographic defect depth \> 4 mm. * full-mouth plaque score (fmps) and full-mouth bleeding score (fmbs) \< 30% (measured at four sites per tooth). * no relevant systemic condition or disease. exclusion criteria: third molars and teeth with type iii mobility or with an incorrect endodontic or restorative treatment. -
effects of caloric restriction on fetuin-a and cardiovascular risk factors

Conditions: Type 2 Diabetes; Overweight

Summary: the aim of this randomized controlled study was to evaluate the effects of cr on circulating fetuin-a levels in obese humans with type 2 diabetes based on monitoring energy intake and energy expenditure by daily activity. furthermore, the investigators examined the relationship between the changes of fetuin-a levels induced by cr and cardiovascular risk parameters including atherogenic lipid profile, visceral fat area (vfa), brachial artery endothelial function, and carotid imt.

rapidly growing aging society augmented the risk of age-associated disorders, such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. dietary interventions that reduce daily energy intake, also known as caloric restriction (cr), has been shown to be the most robust intervention to extend average and maximal lifespan in various experimental animals (1). in addition, cr diminishes the risk of multiple age-associated diseases, such as diabetes, cardiovascular disease, and some forms of cancer in rodents and primates (rhesus monkeys) (1; 2). moreover, in obese humans, cr improves insulin sensitivity and reduces fasting glucose as well as the other components of metabolic syndrome (3). however, the exact underlying mechanism of cr has not been fully defined yet. recently, it is hypothesized that liver may regulate systemic energy metabolism through production of secretory proteins known as hepatokines. fetuin-a, a circulating glycoprotein almost exclusively secreted by the liver, has been found to inhibit insulin receptor tyrosine kinase activity in animal studies (4). fetuin-a knockout (ko) mice have enhanced glucose sensitivity, resistance to weight gain, and lower serum free fatty acid levels (5). in humans, high fetuin-a levels are associated with insulin resistance and fat accumulation in the liver (6). ix et al. reported that higher human fetuin-a concentrations are strongly associated with metabolic syndrome and atherogenic lipid profile in non-diabetic patients with coronary artery disease (7). in addition, fetuin-a levels were associated with surrogate marker of atherosclerosis such as arterial stiffness and intima-media thickness (imt) (8). recent studies reported that elevated fetuin-a levels predict increased risk of myocardial infarction and ischemic stroke (9) as well as type 2 diabetes (10). however, there has been no previous report about the effects of cr on fetuin-a comparing with changes of cardiovascular risk indicators in animals or humans.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * bmi \>= 23 kg/m2 * stable body weight (\<2 kg change in weight in the past 6 months) * sedentary lifestyle (\<20 min of exercise twice a week) exclusion criteria: * smoking * cardiovascular disease * chronic kidney disease * chronic liver disease * pregnant or breast feeding * any major illness * taking medications that could affect laboratory test results

Keywords: type 2 diabetes overweight
prevalence, awareness, attitudes and patterns of stimulant drug use among students in egyptian universities

Conditions: Study of Stimulants in Egypt

Summary: stimulants are dangerous drugs that are commonly abused by individuals looking to stay alert and focused, lose weight, stay awake, and get high. although these drugs can be extremely harmful and even life-threatening, many of them can also be used to treat conditions like adhd, narcolepsy, and in some cases, depression. there are many types of stimulant drugs, and it can be beneficial to know a little about each one, its purposes, and how harmful it can be when abused. illicit stimulants are usually schedule ii, depending on whether or not they can be used to treat medical conditions. while some variations of stimulants are schedule i drugs, most are extremely addictive and dangerous schedule ii substances. these drugs are often abused in a binge-crash pattern. according to the nida teen, "in order to keep the 'high' going, people may take the drug repeatedly within a short period of time, at increasingly higher doses." this makes these drugs extremely addictive. the aim of this survey to detect prevalence of non prescription stimulants in egyptian students and increase their awareness of the harmful effects of these drugs.

methodology undergraduate students at a large public university in egypt (minia, assuit, souhag, south valley) who were 18 years of age or older took the survey in 2024. all survey and recruitment materials were approved by minia university, faculty of pharmacy. students will receive survey through email. students took the survey online at a time and location of their choice. no time limit was imposed. participants will automatically routed through each section of the survey. first, students read a description of the study, including potential benefits and costs of taking the survey, and then they will be asked if they are a current undergraduate student at the participating university and their age. first section included the demographic data of participants, the second section the investigator will aske participants to indicate if they had ever been prescribed a stimulant. if participant answered yes, participants will route to the next section which asks about the frequency of use, the effects of stimulants and any complain if present.

Eligibility criteria:
inclusion criteria: - academic student age (18-30) years included in medical faculty exclusion criteria: * not undergraduates student aged \< 18 years

Keywords: prevalence awareness attitudes stimulant drug egyptian universities
digestnewborn study

Conditions: GDM; Hypoglycemia

Summary: we wish to study the effect of a mothers sugar (glucose) control during pregnancy on her baby's sugar control after birth.


Eligibility criteria:
inclusion criteria: * mothers and their babies who have been enrolled in digest trial and who have provided informed consent exclusion criteria: * none
effects of early manual therapy on functional outcomes after volar plating of distal radius fractures

Conditions: Distal Radius Fracture

Summary: the aim of the study was to investigate the effects of early manual therapy on function, pain, range of motion (rom), hand and pinch grip strength and disability level in patients underwent volar plating after distal radius fracture (drf). patients were randomly divided into two groups: routin physiotherapy (rp) or early manual therapy (emt). while rp group received routine physiotherapy, emt group received routine physiotherapy plus mulligan's mobilization with movement technique. all treatments were done two sessions a week, through 12 weeks. function, pain, range of motion (rom), hand and pinch grip strength and disability level of patients were assessed. measurements were made at postoperative week 3, 6 and 12.


Eligibility criteria:
inclusion criteria: * an age of eighteen years or older * an unstable fracture of the distal end of the radius * fixation with a volar locking plate * able to read, write, and understand turkish * willing and able to attend the study exclusion criteria: * previous fracture on the injured side * concurrent fracture in contralateral upper extremity * accompanied bony and soft tissue injuries other than radius fracture * inflammatory joint diseases, metabolic diseases and neurological diseases * mental and cognitive disorders that would seriously affect cooperation

Keywords: manual therapy radius fracture function disability physiotherapy
a prospective single center clinical study for capsulotomy using the lensx 550 laser

Conditions: Cataract

Summary: the lensx 550 laser system is a femtosecond laser intended for use in performing anterior capsulotomy during cataract surgery. the anterior capsulotomy creates a circular opening in the anterior surface of the capsular bag that contains the cataractous crystalline lens. the objective of this study is to evaluate the ability of the lensx 550 laser to successfully perform anterior capsulotomy during cataract surgery.


Eligibility criteria:
inclusion criteria: * must be eligible to undergo cataract extraction by phacoemulsification with primary intraocular lens implantation in at least 1 eye. * must be at least 24 years of age. * must be willing and able to return for scheduled follow-up examinations. * subjects must sign and be given a copy of the written informed consent form. exclusion criteria: * corneal disease or pathology that precludes applanation of the cornea or transmission of laser wavelength or distortion of laser light. * subjects with a poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally are excluded. * subjects with residual, recurrent, active ocular or eyelid disease, including any corneal abnormality (for example, recurrent corneal erosion, severe basement membrane disease) in either eye are excluded. * history of steroid-responsive rise in intraocular pressure, glaucoma, or preoperative iop\>21 mm hg in either eye. * lens/zonular instability such as, but not restricted to, marfan's syndrome, pseudoexfoliation syndrome, etc. * previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye. * subjects who are pregnant, lactating, or planning to be pregnant during the course of the study. * known sensitivity to planned study concomitant medications. * subjects participating in any other ophthalmic drug or device clinical trial during the time of this clinical investigation. * subjects presenting any contraindications to cataract surgery.

Keywords: capsulotomy
comparative effectiveness and cost-benefit analysis of vancomycin powder in high risk spine surgery patients

Conditions: Surgical Site Infection

Summary: despite the use of prophylactic systemic antibiotics and improved surgical technique, surgical site infections remain a serious concern. the incidence of deep infection after spine surgery has been lowered with systemic antibiotics, yet after instrumented fusion for traumatic injuries infection rates remain as high as 10%. the impact on patients and cost of treating such infections is profound. with diminishing healthcare dollars and policy that refuses to reimburse for postoperative infections, it is critical that physicians and hospital systems seek out cost effective ways of decreasing postoperative infections. local delivery of antibiotics into the surgical site have been found to significantly decrease infection rates in those undergoing posterior spine fusion for traumatic injuries as studied in a retrospective manner by the investigators of this grant. in this proposal the investigators will prospectively randomize patients undergoing posterior spinal stabilization for traumatic injuries into either receiving vancomycin powder into the surgical site (treatment) versus not receiving vancomycin powder (control) and subsequently follow infection rate, complications, and cost of care. the investigator's hypothesis is that i) vancomycin powder will decrease infection rates ii) have no systemic toxicity iii) and be a cost saving advancement in the safety of delivering spine surgical care.


Eligibility criteria:
inclusion criteria * all english-speaking patients ≥ 18 years undergoing posterior spine fusions at vanderbilt university medical center for the treatment of traumatic injuries will be considered for inclusion exclusion criteria * have a known allergy to vancomycin * do not agree to participate * had previous spine surgery at the injury level within 6 months * are pregnant * have a history of steven's johnson syndrome * have a history of infections at the surgical site * have a history of cancer or radiation treatment at the injured level * have open spine fractures * have traumatic injuries to non-spine organ systems that limit their functional capacity
zedebac: zebinix effects in dependency of baseline conditions

Conditions: Focal Epilepsy

Summary: this is a non interventional prospective study. centers will enroll adult participants with partial onset seizures with or without secondary generalisation for whom the clinician has decided to initiate eslicarbazepine acetate (esl) as an adjunctive therapy or monotherapy prior to the decision to take part in this study. participants to be enrolled into the study will receive esl either as an adjunctive therapy to one baseline antiepileptic drug (aed) or to at least two baseline aeds or as monotherapy. participants will be seen at baseline and at a follow-up visit after approximately 6 months to assess retention, efficacy, tolerability, quality of life (optional), and cognitive performances (optional).


Eligibility criteria:
inclusion criteria: 1. partial onset seizures with or without secondary generalisation in conjunction with a diagnosed epilepsy of symptomatic or unknown course. 2. the decision to prescribe eslicarbazepine acetate (esl) was taken independent of and prior to enrollment into this study. 3. treatment with esl is in agreement with the valid summary of product characteristics (smpc) version, particularly with the licensed indication. 4. age 18 years and older. 5. participant's written consent. exclusion criteria: 1. known psychogenic non-epileptic attacks. 2. participation in an interventional study. 3. previous enrollment in the current study.

Keywords: partial onset seizures with or without secondary generalization
implementation of evidence based facility and community interventions to reduce the treatment gap for depression

Conditions: Depression

Summary: the goal of this hybrid type 2 implementation-effectiveness cluster randomised controlled trial is to reduce the treatment gap for depression through the integrated implementation of interventions in facility and community platforms, in goa, india. the primary question is to examine whether a community intervention ("community model") enhances the demand for, and improves the outcomes of, an evidence-based, brief psychological treatment for depression delivered by non-specialist health workers in primary health care facilities ("facility model"). participants in the facility model arm will receive only a psychosocial intervention for depression (the healthy activity program - hap) while participants in the community model will receive both the hap and the community intervention. we will compare the facility model and the community model to assess if the latter is superior in increasing the demand for depression treatment in primary care, increasing uptake of treatment by people with depression, increasing treatment completion rates, and reducing the severity of depression.


Eligibility criteria:
(a) contact coverage outcome inclusion criteria * adults (\>18 years) * residing in the clusters included in the trial * speak english or one of the local languages (konkani, marathi, hindi) exclusion criteria * patients with significant speech, hearing, or language impairment that interferes with completion of the screening and/or receipt of psychosocial intervention * patients who present to the health centre for emergency medical attention * patients with active psychotic symptoms (b) effectiveness coverage outcome inclusion criteria * adults (\>18 years); * residing in the clusters included in the trial * speak english or one of the local languages (konkani, marathi, hindi). * screen positive for moderately severe or severe depression (total score \>14) on the patient health questionnaire-9 items (phq-9) exclusion criteria * patients with significant speech, hearing, or language impairment that interferes with completion of the screening and/or receipt of psychosocial intervention * patients who present to the health centre for emergency medical attention * patients with active psychotic symptoms
effect of metformin on early pregnancy loss in pregnant women with polycystic ovarian syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with polycystic ovary syndrome (pcos).

polycystic ovary syndrome (pcos) is the most common endocrine disorder in women of reproductive age. pcos produces symptoms in approximately 5 to 10% of women of reproductive age (12-45 years old) and is thought to be one of the leading causes of the female subfertility * the aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with pcos * research question: in pregnant women with pcos, does metformin use decreases the rate of early pregnancy loss? -research hypothesis: in pregnant women with pcos, metformin may reduce the rate of early pregnancy loss.

Eligibility criteria:
inclusion criteria: * age : 25 - 35. * pregnant patients in their 1st trimester with history of infertility due to pcos confirmed by at least 2 of the following criteria ( rotterdam criteria ) * at least twelve small follicles 2-9 mm in at least one ovary; diagnosed by ultra sound examination. * symptoms or biochemical evidence of hyperandrogenism; diagnosed by examination and laboratory investigations. * anovulation or oligo-ovulation with fewer than nine menstrual periods every 12 months : diagnosed by thorough history taking. * non diabetic patients who received metformin along with other ovulation-inducing drugs prior to pregnancy. exclusion criteria: * patients with other causes of infertility other than pcos * contraindications to metformin : liver impairment , renal failure. * patients with pcos who didn't receive metformin with drugs of induction of ovulation before pregnancy.
analysis of neuromuscular responses and the balance after the application of physiotherapy resources

Conditions: Musculoskeletal Injuries; Cryotherapy Effect; Complication of Diathermy Procedure

Summary: the aim of this study was to evaluate the effect of ice and shortwave diathermy in different regions of lower limb neuromuscular response and balance.

applying ice and shortwave diathermy was performed separately (on different days) in the foot, ankle and calf. to assess the neuromuscular response was evaluated electromyographic activity of the rectus femorals, biceps femorals, gastrocnemius and tibialis anterior. to assess the effect of applications on balance, through a force platform was evaluated oscillation of the center of pressure as well as ground reaction forces.

Eligibility criteria:
inclusion criteria: * woman * healthy * young * sedentary exclusion criteria: * sensory changes * history of fractures in the lower limbs * being in the menstrual period * diabetes mellitus * bone, muscle and/or neural diseases

Keywords: ice heat ground reaction forces electromyography lower limb center of pressure
clinical and microbiological comparison of 0.12% chx and 0.05% chx+0.05%cpc mouthwashes in tps patients

Conditions: Chlorhexidine; Gingivitis; Periodontitis; Cetylpyridinium Chloride

Summary: the present study compares the effectiveness of two mouthwash formulations (0.12% chx and 0.05% chx+0.05%cpc) in reducing gingival inflammation and microbial colonization in individuals with gingivitis and in preventing periodontitis recurrence. the main focus is on assessing the clinical impact of the mouthwashes over six months, with a secondary goal of evaluating their effect on systemic blood pressure.

this study aims to assess the impact of at-home use of 0.05% cpc + 0.05% chlorhexidine or 0.12% chlorhexidine, combined with professional plaque removal, on gingival inflammation and microbial quantity and quality in individuals diagnosed with gingivitis and reduced periodontium. it seeks to identify the most effective mouthwash formulation for reducing microbial colonization and preventing periodontitis recurrence. comparing the commonly used 0.12% chlorhexidine with the alternative formulation of 0.05% chlorhexidine + 0.05% cpc over one month, with no reported side effects, is the main focus. the study does not pose risks to participants, with the main inconvenience being tooth enamel darkening, which can be easily resolved with professional dental cleaning. the primary objective is to evaluate the additional clinical effect of both formulations after professional plaque removal over six months in patients undergoing supportive periodontal therapy. the secondary objective is to assess the impact of these antimicrobials on systemic blood pressure.

Eligibility criteria:
inclusion criteria: * bleeding on probing (bop) ≥10%, * no more than 4 sites with pocket depth (ppd) \>5mm * presence of attachment loss (al) and radiographic bone loss (rbl) * a minimum of 20 teeth exclusion criteria: * intolerance or allergy to antimicrobials * systemic therapy with anticoagulants/beta-blockers * local/systemic antibiotic therapy 3 months before * inability to understand and sign the written informed consent

Keywords: prevention