Kornimate/medical-research-clean huggingface dataset:
impact of yoga on blood pressure, quality of life and stress in patients with hypertension

Conditions: Hypertension

Summary: the purpose of this study is to determine the effects of a short yoga program practiced daily at home on blood pressure, quality of life and stress. the subjects of the study are primary health care patients diagnosed with hypertension, with or without current medication.

hypertension is one of the most common diseases in the world, affecting approximately 26% of the adult population. persistent hypertension increases the risk of developing coronary heart disease, stroke and other cardiovascular diseases, such as heart failure. hypertension is a common diagnosis in primary health care and the societal costs of examination and treatment of hypertension and its consequences are considerable. the yhip-study (the impact of yoga on blood pressure and quality of life in patients with hypertension), that investigated yoga as additional treatment for hypertension on primary care patients, showed that a short yoga program practiced daily at home had a blood pressure lowering effect as well as a positive effect on self-rated quality of life compared to control. other previous studies have demonstrated positive effects of yoga on blood pressure, quality of life, subjective well-being and stress. however, these studies are relatively few and we need to further investigate the possibility of using yoga as a treatment in primary health care. if the yoga intervention shows to be effective, yoga exercises may be useful as a supplementary bp therapy in addition to medical treatment when prescribed by primary care physicians. it is to be hoped that patients will also experience a higher quality of life and less stress if they perform yoga on a regular basis.

Eligibility criteria:
inclusion criteria: * 30-80 years old * diagnosed with hypertension since at least one year * blood pressure 130-160 mm hg systolic and/or 85-100 diastolic at the last blood pressure control by doctor or nurse. * blood pressure within inclusion- and exclusion-limits at baseline control exclusion criteria: * blood pressure outside the range of 120-180 systolic and 80-110 diastolic at the last blood pressure control or at baseline control. * medical adjustments regarding hypertension within 4 weeks prior to begin of study. * expected inability to understand instructions about yoga exercises (e.g dementia and mental retardation) or physical or psychical inability to carry out yoga exercises (e.g severe physical or psychical handicap). * need for interpreter. linguistic/language difficulties

Keywords: yoga hypertension quality of life primary health care stress anxiety depression
study evaluating gap-486 in heart rhythm

Conditions: Arrhythmia

Summary: the purpose of this study is to learn the effects of a test drug on heart rhythm, and to provide additional data to see if the test drug is well tolerated and safe.


Eligibility criteria:
inclusion criteria: * patients undergoing an electrophysiology study for evaluation of heart rhythm. exclusion criteria: * patients with uncontrolled blood pressure * patients with certain cardiac risk factors * patients with significant kidney or liver problems

Keywords: arrhythmia, syncope, antiarrhythmic
evaluation of postoperative pain with resin based sealer vs zinc oxide eugenol based sealer after single visit endodontic

Conditions: Post Operative Pain

Summary: the goal of root canal therapy is thorough disinfection and obturation of the root canal system in all its dimensions and promote periradicular tissue repair.this study was done to compare the postopertaive pain after single visit endodontics using resin based sealer and zinc oxide eugeonal sealer

a total of 100 patients requiring endodontic treatment for permanent molar in accordance with the inclusion and exclusion criteria will be selected for the study. the treatment and study design will be explained to the patients in their own comprehendible language and a written informed consent will be obtained from the voluntary patients who participated in the study. a cold test and electric pulp-test was used to assess pulp vitality. based on clinical and radiographic findings, the patients diagnosis of irreversible pulpitis. patients will be randomly divided into two groups group a = resin based sealer and group b = zinc oxide eugenol sealer. prior to treatment the patients will be instructed how to complete a visual analog scale (vas) to determine their pain score. the vas included a 10 cm straight horizontal line numbered at each centimeter with the following criteria.local anesthetic with 2% lignocaine containi local anesthetic with 2% lignocaine containing 1:80000 epinephrine will be administered to each patient after recording preoperative pain levels . a rubber dam will be applied. the endodontic access cavities will be prepared with endo access burs .working length will be established with #10 k file and the root canal will be instrumented with one shape rotary system up to #25.6% under copious irrigation with 3% sodium hypochlorite and normal saline. before obturation root canals will be final rinse with 5 ml of 17% edta solution. in both groups, the root canal will be dried with paper points and obturated using gutta-percha cones and resin based sealer/zinc oxide eugenol sealer. coronal access cavities will be restored with direct composite restorations using dentinal adhesives and universal composite resin . postoperative vas scores will be recorded after 24 h and 48 h to determine their post-operative pain.

Eligibility criteria:
inclusion criteria: 1. patient who agree to participate in study 2. asa classification 1or 2 3. minimum age of 18years old and maximum age of 65 years old 4. maxillary and mandibular single rooted teeth included in the study 5. patient with symptomatic irreversible pulpitis with either normal apical tissue or symptomatic apical periodontitis. exclusion criteria: - 1. asa classification 3 to 5 2. patient with immature apices and root resorption will be excluded from the study. 3. severe periodontal problem. 4. vertical or horizontal root fractures will be excluded from the study 5. patients who will be already on analgesia within 24 hours excluded from study 6. those requiring root canal treatment of two or more teeth ipsilaterally (since the pain caused by any of these teeth can result in false positive reading) will be excluded
dyadic sleep study

Conditions: Gastrointestinal Cancer

Summary: the purpose of this study is to learn about sleep behaviors and test different ways to help patients with cancer and caregiver partners.


Eligibility criteria:
inclusion criteria: * the eligibility criteria for patients are: * newly diagnosed with stage i to iv of a gi cancer (anus, colon, esophagus, gallbladder, large and small intestine, liver, pancreas, rectum, stomach, other biliary or digestive organs) * diagnosis in the past 12 months at the time of enrollment * having a consistent sleep partner. * the eligibility criterion for caregivers is: * a sleep partner of the patient. * additional eligibility criteria for both patients and caregivers are: * pittsburgh sleep quality index (psqi) ≥ 5, * willing to change sub-optimal sleep habits, * 18 years or older, * able to speak/listen english at the 8th grade level for intervention sessions, * able to read english or spanish at the 8th grade for self-reported questionnaires, * \> 4 weeks after surgery, if any, prior to enrollment, and no surgery planned in the next 5 weeks during the study period because surgery affects sleep. exclusion criteria: * exclusion criteria for both patients and caregivers are having had a diagnosis of major depressive disorder, psychosis, or bipolar disorder that is not currently treated; * active suicidality, or substance or alcohol dependency in the past year; * currently have narcolepsy, restless leg syndrome, or untreated sleep apnea that is screened using the sleep health screen; * both patients and caregivers have an extreme chronotype, or do shift work to have no overlap in sleep schedule between them; and plan trans-meridian travel during the period of data collection blocks; and having hearing or visual impairment, dementia, or cognitive dysfunction. * adults unable to consent, individuals who are not yet adults, pregnant women, or prisoners will be excluded.
effects of cisatracurium on succinylcholine-induced fasciculations and myalgia

Conditions: Fasciculation

Summary: the purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.

purpose: to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia. methods: ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. general anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. the side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before the induction, at the time of endotracheal intubation, and 5 min after intubation were recorded.

Eligibility criteria:
inclusion criteria: * american standards association (asa) physical status i or ii patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia * 20 - 65 years old * without acid-base imbalance and electrolyte disturbance * with normal hepatic and renal function exclusion criteria: * patients with known hyperkalemia * patients with increased intraocular pressure * patients with increased intracranial pressure * patients with symptoms of gastroesophageal reflux * patients with anticipated airway difficulties * patients with malignant fever * patients with neuromuscular disease * patients with burn or crush injuries * patients with taking drugs known to alter the action of neuromuscular blockers * patients with with a body mass index exceeding 30

Keywords: cisatracurium myalgia fasciculation succinylcholine
a study to evaluate the efficacy and safety of incb054707 in participants with prurigo nodularis

Conditions: Prurigo Nodularis

Summary: the purpose of this study is to evaluate the efficacy and safety of incb054707 in participants with prurigo nodularis over a 16-week double-blind placebo-controlled treatment period, followed by a 24 -week single blind extension period.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of pn for at least 3 months before screening. * inadequate response or intolerant to ongoing or prior pn therapy. * ≥ 20 pruriginous lesions on ≥ 2 different body regions at screening and day 1. * willingness to avoid pregnancy or fathering children * further inclusion criteria apply. exclusion criteria: * have chronic pruritus due to a condition other than pn; have neuropathic and psychogenic pruritus such as but not limited to notalgia paresthetica, brachioradial pruritus, small fiber neuropathy, skin picking syndrome, or delusional parasitosis. * current use of a medication known to cause pruritus. * women who are pregnant (or who are considering pregnancy) or lactating. * medical history including thrombocytopenia, coagulopathy or platelet dysfunction, q-wave interval abnormalities, current or history of certain infections, cancer, lymphoproliferative disorders and other medical conditions at the discretion of the investigator. * have evidence of active or latent or inadequately treated infection with mycobacterium tuberculosis. * participants known to be infected with hiv, hepatitis b, or hepatitis c. * laboratory values outside of the protocol-defined ranges. * further exclusion criteria apply.

Keywords: prurigo nodularis pn incb054707 chronic pruritus
family integration in therapy activities in the intensive care unit: the fit-icu feasibility study

Conditions: Critical Illness; Delirium

Summary: an icu admission is stressful for not only patients but their families as well. research has shown that involving family members during a loved one's icu stay can be helpful for them, but there is not clear direction on the best way to do this. for patients, family presence as well as early movement during their icu stay has been shown to help recovery from things like delirium (a state of confusion) faster, and might prevent the weakness that can happen with a stay in the icu. in this study, the investigators will explore whether having family help with moving patients through physiotherapy guided exercise can help both patients and families have a better experience and result from their icu stay. the investigators hypothesize that family involvement in activities as part of an overall physiotherapy treatment plan will provide a tangible means for family members to engage in the care of their critically ill loved one, thus improving outcomes for both critically ill patients and family members.


Eligibility criteria:
inclusion criteria: * adults (≥18 years) in the icu * anticipated length of stay ≥48 hours for whom a request for physiotherapy has been placed by the treating physician * appropriateness for physiotherapy confirmed by the unit's physiotherapist. * families will be eligible if they are able to be present in icu during physiotherapist or research team work hours until they are cleared to deliver activities independently, then at least three times weekly thereafter. exclusion criteria: * patients who are receiving end of life care * patients who have high risk injuries including spinal cord injury or spinal fractures, post-operative from spinal surgery, and untreated hip or long bone fractures * patients at risk of raised intracranial pressure (icp) (e.g. malignant middle cerebral artery stroke, large subarachnoid hemorrhage), admitted post trauma activation, post-operative from brain surgery or with external ventricular drain (evd) in situ. * patients who are bed-bound or require mechanical lift at baseline who would not otherwise be offered physiotherapy services. * exclusion criteria for families include any major barriers to participation, i.e., physical, cognitive, emotional or capacity to understand and communicate with the team.
gene regulation by thiazolidinediones

Conditions: Inflammatory Bowel Disease

Summary: the purpose of this study is to determine the effect of rosiglitazone on the genes of the colon

the primary aim of the study is to examine the effect of rosiglitazone (avandia) on gene regulation in colonic epithelium in the absence of pathologic acute and chronic intestinal inflammation. the secondary aims are to determine the effect of rosiglitazone (avandia) therapy on t cell activation and cytokine expression in the absence of pathologic acute and chronic intestinal inflammation.

Eligibility criteria:
inclusion criteria: * capable of giving informed consent * agrees to use a barrier method of birth control for the duration of the study exclusion criteria: * history of inflammatory bowel disease * has taken prescription or over the counter medications in the two weeks prior to enrollment * history of diabetes, heart failure, angina, hypertension, coronary heart disease, cancer, bleeding disorder, hiv, aids * fasting ldl \>160 mg/dl * history of smoking in the year prior to enrollment * pregnant or breastfeeding
a study to evaluate the safety and efficacy of basmisanil in adults with severe motor impairment following an ischemic stroke

Conditions: Stroke

Summary: this phase iia, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic stroke.


Eligibility criteria:
inclusion criteria: * radiologic assessment confirming an acute middle cerebral artery ischemic stroke * index stroke occurred within the past 3-4 days * inpatient males and females * severe hemiparesis or hemiplegia defined by fmms score less than or equal to (\</=) 35 * sufficient speech, vision and hearing to participate in study evaluations exclusion criteria: * nihss greater than (\>) 20 * severe aphasia that prevents a participant from following directions in rehabilitation * significant deficit from prior strokes or pre-existing motor deficit * history of epilepsy, neurosurgery, severe head trauma or central nervous system infections that have residual symptomatology or have required treatment in the last 12 months * known or suspected clinical seizure post-index stroke * history of pre-existing dementia or use of medications for dementia * history of clinically significant pre-existing psychiatric conditions within 12 months prior to stroke * due to undergo carotid surgery within the next 4 months * enrollment/participation in any interventional study (clinical trial) involving an investigational drug (unapproved) or non-drug treatment within the prior 3 months or 6 times the half-life (whichever is longer) * clinically relevant medical conditions that would likely interfere with the study conduct and scheduled assessments * contraindication to magnetic resonance imaging (mri) or conditions which render interpretation of mri difficult

Keywords: stroke motor impairment stroke recovery middle cerebral artery stroke fugl meyer fugl-meyer motor scale (fmms)
pocd: correlations with the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin b12.

Conditions: Postoperative Cognitive Dysfunction

Summary: to study on the postoperative cognitive dysfunction: correlations with the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin b12. to explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin b12 could be used as predictor(s) of pocd and to provide reference for pocd prevention, early detection and timely diagnosis and treatment.


Eligibility criteria:
inclusion criteria: * non-cardiac surgery patients; * age is greater than or equal to 60 years old; * han nationality, mother tongue is chinese; * the mmse score: illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; * the geriatric depression scale (gds) grade 1 or 2; * the important function without serious heart, brain, liver, kidney, lung and other organs; * the asa class i or ii; * the people signed informed consent. exclusion criteria: * the diagnosis of neurological and psychiatric disorders, such as alzheimer's disease, parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; * had severe head and face disease, trauma history or history of surgery; * the serious body disease and tobacco, wine and other substance abuse history; * the presence of malignant tumor with shorter survival disease.

Keywords: non-cardiac surgery postoperative cognitive dysfunction
characterizing cognitive decline in late life depression: the adni depression project

Conditions: Major Depression; Late Life Depression (LLD)

Summary: the purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in late life depression (lld). this is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. from the originally enrolled participants, the continuation of the adni-d study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. data from an additional 300 non-depressed subjects will be used from adni studies for comparison. depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. an magnetic resonance imaging (mri) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (pet) imaging will be conducted at san francisco va. collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. blood samples will also be collected for genetic analysis.


Eligibility criteria:
inclusion criteria: 1. individual participated in original characterizing cognitive decline in late life depression study or multimodal mri characteristics of psychotherapy response in late life depression study. exclusion exceptions: 1. antidepressant medication treatment is allowed only if the medication dose is stable for 4 weeks prior to the mri scan. 2. psychotherapy interventions is allowed only if they have completed at least 4 weeks of individual or group psychotherapy intervention prior to the mri scan. 3. participants taking cognitive enhancing medications will be able to enter the study.

Keywords: depression late life depression lld amyloid imaging biomarkers
repetitive transcranial magnetic stimulation for post-concussion headaches

Conditions: Brain Concussion; Mild Traumatic Brain Injury; Headache; Post-Concussion Symptoms

Summary: this study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rtms), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mtbi). rtms has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. this study uses rtms to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. this project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mtbi.


Eligibility criteria:
inclusion criteria: * 18 - 55 years old who were actively working prior to mtbi * mtbi with loss of consciousness for less than 30 min, initial glasgow coma scale between 13 and 15, or post-traumatic amnesia for ≤ 24 hours * diagnosis of persistent post-traumatic headache according to the international classification of headache disorders, 3rd edition (ichd-3) criteria * headache develops within 7 days after head trauma * headache persists for \>=3 months after head trauma despite receiving standard care * average persistent headache intensity is \>= 3/10 of the numerical rating scale (nrs) on \>=3days/week * no evidence of radiculopathy or peripheral neuropathy on electromyography or clinical evaluation * no evidence of other possible causes of headaches exclusion criteria: * history of chronic headache diagnoses such as migraine, tension, or cluster headaches prior to the incidence of mtbi * history of other neurologic conditions with medications affecting the central nervous system * contraindications of receiving tms (e.g., a history of epileptic seizure and having implants like a cardiac pacemaker or intracerebral vascular clip

Keywords: repetitive transcranial magnetic stimulation non-invasive brain stimulation neuromodulation chronic pain biomarkers