Kornimate/medical-research-clean huggingface dataset:
lacrimal drainage system obstruction associated to radioactive iodine therapy for thyroid carcinoma

Conditions: Lacrimal Apparatus Disease

Summary: the radioactive radioiodine therapy (na131i) for the treatment of differentiated thyroid carcinoma is a procedure used for ablation of remaining thyroid tissue after thyroidectomy and metastases. although serious complications are uncommon after treatment, there are well-documented adverse reactions secondary to the involvement of the salivary glands, such as dry mouth, pain in the parotid glands and dysphagia, even after administration of low doses of radioiodine. however, ocular complications of such treatment are scarcely reported in literature. among them the investigators can mention recurrent and chronic conjunctivitis, keratoconjunctivitis sicca and dry eye, affecting 23% of patients undergoing radioactive iodine therapy. dysfunction of the lacrimal gland is described in recent studies, especially after high cumulative dose of the drug. likewise, epiphora and nasolacrimal duct obstruction have been reported as complications associated with the use of radioiodine, although studies are not available to assess its true incidence through the systematic evaluation of patients. it can be seen in routine practice that these patients would normally be referred for ophthalmological examination only if a complaint, what happens in the process of ovl already installed after the use of high doses of radioiodine. with the early evaluation of these patients, the investigators focused on detecting the process of ongoing obstruction in order to study interventions that prevent its final installation.


Eligibility criteria:
inclusion criteria: * thyroid carcinoma * previous thyroidectomy exclusion criteria: * potential causes of dry eye (autoimmune diseases, contact lens wearers or drugs that alter tear production, such as antihistamines and psychotropic) * use of other anti-neoplastic, such as 5-fluorouracil and docetaxel, which can cause epiphora and ovl * lacrimal gland / ocular trauma * radiation therapy for other diseases or radiotherapy of head and neck * patients with diseases that alter the neural control of tear secretion, hormone therapies, pterygium, graves' disease with or without ophthalmopathy, blepharitis and other conditions that may reduce tear production or result in rapid evaporation.

Keywords: iodine radioisotopes nasolacrimal duct radiation effects
are alterations in shoulder rotations and core stability effective for water polo shoulder problems?

Conditions: Shoulder Injuries; Sport Injury; Sports Physical Therapy

Summary: hypothesis of the clinical study: there are differences between the water polo group and the non-water polo group in terms of shoulder parameters and core (lumbopelvic) parameters and there are differences between the throwing and non-throwing sides in terms of shoulder parameters in water polo group.


Eligibility criteria:
inclusion criteria: * participating to the study in a voluntary basis. * participant in ages between 10-30 years of age. * parent permission for participants younger than 18 * giving consent for older than 18 exclusion criteria: * having a history of orthopaedic surgery in the shoulder girdle within the last 6 months * having a history of fracture within the shoulder girdle complex * having a shoulder problem within the last 6 months continuing more than 3 months * having a history of pathology in lumbar area within the last 6 months
comparison of self-assessment vs. assessment by others of critically ill patients

Conditions: Critical Illness; Self-Assessment; Assessment, Self

Summary: we will test the results of standardized questionnaires for patients admitted to intensive care assessed by relatives/caregivers compared to the patient itself. furthermore we will compare results with patients not admitted to intensive care.


Eligibility criteria:
inclusion criteria: * patient with a postoperative risk to be admitted to intensive care * signed informed consent exclusion criteria: * patient who is not able to fill out the questionnaires alone and independent * patient without relatives or a caregiver who could answer the assessment after surgery

Keywords: assessment by others self-assessment critically ill intensive care standardized questionnaire functional status whodas eq5d iadl barthel score sf-36 moca blind
tau pet imaging in northern manhattan study of metabolism and mind

Conditions: Diabetes Mellitus; Alzheimer Dementia

Summary: the purpose of this project is to study brain imaging of a substance called tau, which is found in brains of persons with alzheimer's disease, using the tau binder, 18f-thk-5351, for live imaging of tau in the brain. the main goal of this proposal is to study whether diabetes status (type 2 diabetes \[referred to as diabetes\] and pre-diabetes, compared with normal glucose tolerance \[ngt\]), is associated with increased tau accumulation in the brain, one of the culprits of alzheimer's disease, in a community-based group of middle aged caribbean-hispanics with a mean age of 63 years. the investigators propose to conduct tau positron emission tomography (pet) imaging in 30 middle aged hispanics.

the burden of late onset alzheimer's dementia (load) and its antecedents is increasing without known prevention or cure, and diabetes seems to be one of the strongest risk factors. the predominating causal model in alzheimer's disease (ad) research is based on the amyloid hypothesis, which posits that amyloid (a) deposition in the brain causes synaptic dysfunction resulting in early memory deficits and progression to mild cognitive impairment (mci) and dementia. tau has also gained increasing interest as an ad pathology feature, biomarker, and treatment target. there are no known curative or preventive measures for load. one of the strongest potential load risk factors is type 2 diabetes, an abnormal elevation of blood glucose associated with microvascular and macrovascular complications including cerebrovascular disease. many studies have reported an association of diabetes with dementia, including load and vascular dementia (vd). most studies have found that diabetes is associated with an increased risk of both load and vd, with a stronger association for vd compared with load. thus, this study focuses on the relation of diabetes, pre-diabetes, and elevated glucose, with ad.

Eligibility criteria:
inclusion criteria: * all persons who have undergone magnetic resonance imaging (mri) and amyloid pet already, or those who prospectively are deemed eligible for the parent study covered under protocol aaaq2950, will be approached for participation. exclusion criteria: * person who are not participating in the mri and amyloid pet under protocol aaaq2950

Keywords: diabetes mellitus alzheimer's disease dementia thk
peri-conception key nutritional factors and congenital heart disease

Conditions: Congenital Heart Disease

Summary: the study is a nested case-control study and the purpose is to describe the status of key nutrients(eg.folic acid and vitamins) supplementation among pregnant women in shanghai, to find out the association between the level of serum key nutrients during peri-conceptional period and the incidence of congenital heart defects (chd) in newborn, and to provide better preconception care.

congenital heart defects (chd) are among the most common major congenital anomalies with an incidence of about 8-12/1,000 live births worldwide. the mechanism of chd is still unclear. many studies indicated that the level of key nutrients (eg.folic acid and vitamins) during peri-conceptional period might affect the incidence of chd, but the evidence is limited. the study aimed to explore the association between serum key nutrients during peri-conceptional period and the incidence of chd in newborn. all couples attending pre-pregnancy physical examination from 11 districts (minhang district, huangpu district, xuhui district, changning district, jingan district, putuo district, yangpu district, jiading district, pudong district，songjiang district, qingpu district) in shanghai from march 2016, are recruited and their blood samples and questionnaires about the supplementation of key nutrients are collected. during the gestation, venous blood of pregnant women at all of three trimesters is taken. besides, questionnaires about the supplementation of key nutrients at the first antenatal visit are also obtained. the level of serum folic acid, vitamin a and vitamin b12 at preconception and during gestation are measured. finally, investigators identifies those whose newborns developed chd during follow-up as the cases. then, investigators selects four controls for each case from the rest of the cohort by matching on constitutional determinants of chd such as age and sex. participants are identified by national identification number during the follow up. the level of serum key nutrients is compared in cases and controls. univariate and multivariate association analyses will be performed to identify risk factors to chd by using multivariate logistic regression model.

Eligibility criteria:
inclusion criteria: * attend pre-pregnancy physical examination from 11 districts in shanghai, or pregnant women present at first antenatal care \< 14 week of gestation * plan to deliver in shanghai exclusion criteria: * none

Keywords: congenital heart disease key nutritional factors conception pregnant
pupillometry in delayed sleep wake phase disorder

Conditions: Delayed Sleep-Wake Phase Disorder

Summary: the goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. a subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. the main questions it aims to answer is: are there differences in the light response in patients with delayed sleep-wake phase disorder? does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? participants will complete activity and melatonin testing at home to determine their circadian timing. this will be followed by an eye test looking at the pupil response to different light stimuli. a subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. during one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.


Eligibility criteria:
inclusion criteria: * delayed sleep-wake phase disorder exclusion criteria: * use of medications known to alter pupil diameter * history of eye disease or eye surgery * unstable medical or psychiatric condition * shift work or self imposed irregular sleep schedules * caffeine consumption \>400mg/day
open-label, safety and tolerability extension study of kns-760704 in amyotrophic lateral sclerosis (als) (cl211)

Conditions: Amyotrophic Lateral Sclerosis

Summary: this is an open-label, multi-center study designed to extend the evaluation of the safety, tolerability, and clinical effects of oral administration of kns-760704 in patients with als.

patients who complete the part 2 week 28 visit in study kns-760704-cl201 and patients with als who were actively receiving rtpb \[(6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazolediamine dihydro-chloride monohydrate\] under research ind #60,948 were eligible to participate in this study. eligible patients received 1 tablet of kns-760704 (150 mg) every 12 hours (q12h) (300 mg total daily dose) for up to 180 weeks.

Eligibility criteria:
inclusion criteria: 1. patient has provided signed informed consent for this trial before the commencement of any study-related procedure 2. patient is actively participating in knopp protocol kns-760704-cl201 and has completed the part 2 week 28 visit in that study or patient is actively receiving rtpb under research ind #60,948 exclusion criteria: 1. patient did not participate in knopp protocol kns-760704-cl201 or patient did not receive rtpb under research ind #60,948. 2. patient discontinued from kns-760704-cl201 for any reason other than enrollment into this study (applies to patients enrolled in kns-760704-cl201 only) 3. patient was not taking rtpb under research ind #60,948 prior to april 30, 2009 (applies to patients enrolled under research ind #60,948 only)

Keywords: als amyotrophic lateral sclerosis lou gehrig lou gehrig's lou gehrig's disease motor neuron disease nervous system diseases kns-760704 rtpb
fet-pet for diagnosis and monitoring in patients with low grade glioma

Conditions: Astrocytoma; Oligoastrocytoma; Oligodendroglioma

Summary: the aim of the study is to compare the two imaging modalities perfusion weighted mr-imaging and fet-pet in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. additionally, therapeutic effects should be assessed during a time period of two years.


Eligibility criteria:
inclusion criteria: * neuroradiologically suspected low grade glioma (astrocytoma whoi-ii, oligodendroglioma who ii, oligoastrocytoma who ii) * histological verification will be obtained either by microsurgery or by stereotactic biopsy * patients older than 18 years * karnofsky performance score \>=70 * pregnant or nursing female patients will not be included in this study exclusion criteria: * patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills * patients who cannot lie quiet for a time period of app. two hours during the fet-pet scan * medical history of a metastatic brain disease * patients in whom an mri scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc.

Keywords: low grade glioma astrocytoma molecular imaging fet pet therapy monitoring temodar
efficacy of an assisted therapy optimizing module to improve physician adherence

Conditions: Heart Failure

Summary: heart failure patients within the hm programme

a prospective, randomized, multi-sectoral multi-centre study with parallel group design. application of guideline-directed medical therapy (gdmt) improves quality of life and decreases hospitalization for heart failure and mortality. gdmt is in general underused. this also applies to patients who are cared for in the integrative, telemedicine-supported disease management program herzmobil tirol (hmt). the assisted therapy optimizing module has been designed to actively assist network physicians in adhering to and improving guideline-based medical therapy.

Eligibility criteria:
inclusion criteria: ampel, cip, version: 1.2 date: 27.03.2024 1. written, signed and dated informed consent for inclusion in the hm programme 2. male and female patients over 18 years of age. 3. hospitalised for decompensated heart failure requiring intravenous diuretics 4. need for iv diuresis in nonhospital setting because of impending hospitalization for cardiac decompensation exclusion criteria: 1. multimorbidity (charlson comorbidity index \> 6) 2. dementia 3. lack of willingness to participate

Keywords: heart failure
safety and efficacy of oral bay85-8501 in patients with non-cf (cystic fibrosis) bronchiectasis

Conditions: Bronchiectasis

Summary: the primary objective of this study is to assess the safety and tolerability of 28 day oral administration of bay85-8501 versus placebo in subjects with non-cf bronchiectasis (be). the secondary objectives are to examine the effect of bay85-8501 on pulmonary function, biomarkers of inflammation and tissue damage, and the impact on overall health and perceived well-being and to evaluate the pharmacokinetics of bay85-8501.


Eligibility criteria:
inclusion criteria: * proven and documented diagnosis of non-cf (cystic fibrosis) idiopathic or post-infectious be (bronchiectasis) by computed tomography (ct) scan \[conventional high resolution ct is considered the standard\], including 2 or more lobes and dilated airways compatible with be at initial diagnosis * stable pulmonary status as indicated by the forced, expired volume in 1 second (fev1) percent predicted ≥30% and \<90% (post-bronchodilator) * stable (i.e., no dose change) regimen of standard be treatment administered at least for 4 weeks prior to screening * cough on most days exclusion criteria: * forced, expired volume in 1 second \<30% or ≥90% predicted (post-bronchodilator) * recent significant hemoptysis (≥300 ml or requiring blood transfusion) in the preceding 4 weeks before screening (and during the screening period) * known cystic fibrosis and/or documented chronic bronchial asthma * active allergic bronchopulmonary aspergillosis (abpa) * diagnosis of common variable immunodeficiency (cvid) * systemic or inhaled antibiotic treatment within 4 weeks prior to screening * treatment of an exacerbation within 4 weeks prior to screening * systemic corticosteroids at \>10 mg/day prednisolone equivalent for \>2 weeks within 4 weeks prior to screening

Keywords: elastase inhibition
pre-surgical intervention for targeted therapies for breast cancer

Conditions: Invasive Breast Cancer

Summary: the purpose of this study is to determine the feasibility of a short term administration of a targeted therapy (i.e., anastrozole) in women with newly diagnosed early invasive or non invasive breast cancer during the interval between their breast biopsy and surgery. anastrozole is a form of hormonal therapy which is part of the standard treatment for hormone sensitive breast cancer in postmenopausal women. this clinical model is being used to evaluate the biologic effects of this drug on a specific molecular pathway called the pi3k/akt signaling pathway.

several clinical models are being explored for use in the phase i/ii evaluation of targeted therapies for breast cancer. biological markers can be measured in early stage invasive cancers in a presurgical model involving a short term intervention. in this model, women with newly diagnosed early invasive breast cancer receive a study drug during the interval between diagnostic breast biopsy and surgical resection. tumor tissue obtained from the biopsy and surgical specimens are used to measure pre and post treatment molecular markers, respectively. the main advantages of this model include the ability to obtain direct information on molecular response in tumor tissue and elucidate drug mechanisms of action, the large patient population to draw from with early stage breast cancer, and the lack of unnecessary invasive procedures. we plan to conduct a pilot study of 10 postmenopausal women with newly diagnosed estrogen receptor (er) positive invasive or non invasive breast cancer who will receive oral anastrozole 1mg daily for two weeks in the interval between diagnostic breast biopsy and definitive breast surgery. patients will be identified by the breast surgeon or mammographer performing the breast biopsy. patients with histologically confirmed er+ invasive or non invasive breast cancer will be recruited by the medical oncologist and will start anastrozole two weeks prior to their scheduled surgery. the primary objective of this study is to demonstrate the feasibility of this presurgical model for evaluating targeted therapies for breast cancer. secondary endpoints include changes in tissue levels of the proliferation marker ki67 and proteins involved in pi3k/akt signaling.

Eligibility criteria:
inclusion criteria: * histologically-confirmed operable er+ and/or pr+ invasive breast cancer or ductal carcinoma in situ (dcis), who undergo core needle biopsy followed by surgical excision at least 2 weeks after enrollment * postmenopausal status defined as cessation of menses for \>1 year or fsh \> 20 miu/ml (within the past month) * age ≥ 21 years * no prior chemotherapy, radiation therapy, or surgery within 6 months of study entry * signed informed consent exclusion criteria: * treatment with other investigational drugs within 6 months of study entry * other serious intercurrent medical illness

Keywords: postmenopausal women er+ estrogen positive pr+ progesterone positive
interactive robot on pre-operative anxiety and fear of children

Conditions: Surgery

Summary: the aim of this study is to determine the effect of preoperative preparation applied with an interactive robot on children's preoperative anxiety and fear levels. hypothesis; h1: pre-operative preparation with an interactive robot has an effect on the anxiety level of children h2: pre-operative preparation with an interactive robot has an effect on the fear level of children h3: the anxiety levels of children in intervention and control groups are different after the pre-operative preparation h4: the fear levels of children in intervention and control groups are different after the pre-operative preparation

the use of interactive robots can be preferred as a remarkable method of communication with hospitalized children. in this way, it will be easier for the children to understand the procedure and they will be able to communicate easily with healthcare professionals. children may develop a sense of control and the level of anxiety and fear they experience may decrease when they interact with robots. it is reported in the literature that children show more interest in robots than they do in adults. in addition, children see social robots as living creatures, not as devices, and children who spend time with them for a long time adopt them as friends. in a study, a social humanoid robot was used to prepare children aged 7-12 (n = 11) regarding the cancer diagnosis process and interventional procedures. according to the results of the study, the children's stress, depression, and anger during the treatment decreased significantly. interactive robots positively affect postoperative mobilization in children undergoing day surgery and reduce the anxiety level of children before mobilization. as a result, it may be easier for children to cope with stress with the use of interactive and humanoid robots. also, interactive robots can facilitate cooperation between the child and the nurse by playing an intermediary role in communication with children. determining the effects of interactive robots on children by using them before the surgical procedure is important to ensure the active participation of children in the surgical process in pediatric surgery clinics. it is thought that this research is important in terms of interventions which appropriate to the supportive care role of nurses and will contribute to the literature.

Eligibility criteria:
inclusion criteria: * those between the ages of 5-10, * having planned day surgery, * scheduled for general anesthesia * have not had surgery before, * those who can speak turkish exclusion criteria: * children have mental-cognitive problems, * children have hearing, vision and/or speech disabilities

Keywords: minor surgical procedures nursing interactive robot chlidren