Kornimate/medical-research-clean huggingface dataset:
identification of anxiety and depression in adolescents/young adults (aya) with cancer

Conditions: Cancer; Depression, Anxiety

Summary: this is a prospective, multisite (but all within the utsw irb), observational study assessing the relationship of hope to anxiety and depression, qol, and social support over time in the first year after cancer diagnosis or relapse in aya (ages 15-29 years of age).

the principal investigators' ongoing work suggests hope is a target for intervention to improve quality of life (qol) and reduce anxiety and depression (a/d) among adolescents/young adults (aya). no study to the investigators' knowledge has evaluated the promising impact of hope interventions in aya cancer patients. to address this gap, the investigators will expand the investigators' prior research on hope, a/d, and qol to aya receiving care across three diverse healthcare systems. patients will be approached for participation within 3 months of their initial/relapse cancer diagnosis. eligible patients (and the parent/caregiver for minor patients) will be approached in a private area of the clinic or hospital room to explain the research aims and informed consent process. after obtaining informed consent/assent (from parents if patients are under 18, from aya if patient is 18 or older), participants (patients) will utilize an ipad to complete measures via redcap.

Eligibility criteria:
inclusion criteria: * adolescents and young adults (15-17, 18-29 years of age, respectively) with a new or relapse diagnosis of a malignancy * patients will include those being followed (treatment or observational) for any malignant disorder at children's medical center, ut southwestern medical center, or parkland health and hospital systems * patients whose native language is spanish or english are eligible to participate * patients may have any life expectancy * ability to understand and the willingness to sign a written informed consent. exclusion criteria: * patients with clinically apparent cognitive disabilities which would preclude understanding and completion of measures. * patients with significant medical issues such as delirium which preclude their ability to consent and complete initial measures
lifestyle and dietary pattern in relation to precursor lesions of colorectal cancer and cardiometabolic diseases

Conditions: Polyps; Cardiovascular Diseases

Summary: the association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. this study is conducted in jinhua, a city with a high prevalence of colorectal cancer in china, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

investigations of lifestyle and dietary factors in relation to precursor lesions of colorectal cancer and cardiometabolic diseases are limited in china. the investigators aim to collect the basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors and so on, to assess the associations between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases. this large cohort - the lanxi pre-colorectal cancer cohort (lp3c) also included several subcohorts consisting of patients with cvd, diabetes, hypertension, metabolic syndrome, obese/overweight or fatty liver disease. results from this study will be valuable for colorectal cancer and cardiometabolic disease prevention in china.

Eligibility criteria:
inclusion criteria: * subject aged ≥45 and ≤74 years old * subject has complete data on diet and follow-up time exclusion criteria: * colorectal cancer * severe intestines problems

Keywords: dietary factors precursor lesions of colorectal cancer lifestyle polyps cardiovascular diseases
novel imaging techniques for the characterization of musculoskeletal tumors ii

Conditions: Soft Tissue Neoplasm; Bone Neoplasm

Summary: this study aims at evaluating the value of various artificial intelligence based techniques to improve the characterization and image post-processing for patients with musculoskeletal tumors.

comparison of values relating to the texture parameters of tumors evaluated by mri and ultra-high resolution ct between benign and malignant lesions using histological analysis as the standard of reference. comparison of the diagnostic performance of texture parameters derived from different mri sequences and ultra-high resolution ct for musculoskeletal tumor characterization. evaluate the impact of ultra-high resolution with respect to standard resolution on ct images comparison of the diagnostic performance of the texture parameters for the tumor on the diagnostic performance of texture analysis derived parameters for the characterization of musculoskeletal tumors. evaluate the effectiveness and accuracy of automatic artificial intelligence (ai) based tumor segmentation tools. evaluate the use of trabecular analysis on ultra-high resolution ct images for the evaluation of tumor-bone interfaces.

Eligibility criteria:
inclusion criteria: * patients suspected to have a bone or soft-tissue tumor referred for imaging for initial tumors characterization and staging. exclusion criteria: * pregnancy * breast feeding patients * renal insufficiency * contra indications to mri or ct * prior surgery or treatment to the evaluated lesion.

Keywords: mri ct texture analysis ultra-high resolution tumors musculoskeletal
multi-omics for maternal health after preeclampsia

Conditions: Pre-Eclampsia; Pregnancy Induced Hypertension

Summary: to develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies.

the investigators will recruit and retain a diverse population of pregnant women who are high- and low-risk for hypertensive disorders of pregnancy/preeclampsia (hdp/pe) for longitudinal collection of phenotypic and environmental exposure measures and biosamples for integrative analysis of phenotypic, environmental, and multi-omic data to understand links between development of hdp/pe and associated fetal pathologies during pregnancy, as well as postpartum maternal health. participation in the study will begin no later than the second trimester of pregnancy (enrollment by 24 weeks of gestation) and continue through the first year postpartum. over the course of the study, biospecimens and relevant surveys and cardiovascular assessments will be collected at specified intervals/time-points, as outlined in the table below. in-person study visits should take no more than 30 minutes. relevant medical information collected as part of routine clinical care will be obtained from the electronic medical record (emr). the study will take place at ucsd and vumc prenatal clinics and hospital labor and delivery units, or another private location of the participants choosing, such as their home or office.

Eligibility criteria:
inclusion criteria: * pregnant women 18 years of age to 50 years of age * 10-24 weeks gestation at time of enrollment * singleton pregnancy * planning to deliver at a study site (ucsd or vumc) exclusion criteria: * inability to give informed consent * intrauterine fetal demise * fetal genetic or structural anomaly * institutionalization for psychiatric disorder, mental deficiency or incarcerated * active or history of malignancy requiring major surgery or systemic chemotherapy * multi-fetal gestation or a twin demise at any gestational age * known maternal or fetal chromosomal anomalies * patients who plan to keep their placenta after delivery

Keywords: hypertension pregnancy pre-eclampsia postpartum
testing of different methods for determining whether breast cancer has spread to the lymph nodes

Conditions: Breast Neoplasms

Summary: sentinel lymph node biopsy (slnb) has recently emerged as a less invasive alternative to axillary lymph node dissection (alnd) in the treatment of breast cancer. however, slnb has a number of limitations, and we believe that alternative strategies for staging of the axilla should be explored. the hypothesis of this proposal is that the combination of preoperative high-resolution axillary ultrasound (aus), fine needle aspiration biopsy (fnab), and molecular analysis using real-time reverse transcription-polymerase chain reaction (rt-pcr) represents a viable, minimally invasive alternative to slnb. we propose a prospective cohort study to rigorously assess the diagnostic accuracy of molecular analysis of aus-fnab specimens. the primary endpoint of this study is to determine the feasibility of aus-fnab and real-time rt-pcr to predict the pathologic status of the axilla in a proof-of-principle study. in the short term, validation of this innovative strategy is likely to reduce the number of sentinel node procedures. in the long term, we believe that aus-fnab may ultimately replace slnb.


Eligibility criteria:
inclusion criteria: * female patients, aged 18 and over. * patients must be newly diagnosed with clinical stage i or ii breast cancer and be eligible for breast surgery and core breast biopsy of their proven breast carcinoma. exclusion criteria: * inability to give informed consent * contraindications for breast surgery or biopsy patients with no evidence of malignancy scheduled to undergo procedures under general anesthesia must fulfill the following eligibility requirements: * female patients, aged 18 and over * patient must be scheduled to undergo a procedure under general anesthesia with access to lymph nodes that can be biopsied by fna biopsy at minimal risk to the patient * patient must be willing to give informed consent * patient with no history of malignancy

Keywords: breast cancer axilla ultrasound fna molecular analysis
yoga for patients with epilepsy

Conditions: Epilepsy

Summary: to establish the safety and feasibility of having patients with epilepsy perform yoga.

subjects will keep logs of seizure frequency prior to, during, and following training in a yoga regimen. instruction in the yoga regimen will occur at bidmc, and home practice following classroom instruction will occur as part of the study. side effects, changes in seizure frequency, and quality of life assessments will be performed.

Eligibility criteria:
inclusion criteria: 1. must be able to give full informed consent. 2. must have one or more of the following seizure types: simple partial, complex partial, or secondarily generalized. 3. age 18-64. 4. must have 4-20 during the baseline phase. 5. must have medical clearance from their primary care giver sufficient to allow for participation in yoga exercises. 6. must be stable enough to allow for all anticonvulsant levels to remain constant for the duration of the study. exclusion criteria: 1. having primary generalized epilepsy or atonic seizures. 2. having a history of status epilepticus in the past two years. 3. any medical problem that would preclude participation in a yoga class. 4. nonepileptic or psychogenic seizures. 5. pregnancy.

Keywords: epilepsy, yoga
effects of ischemic preconditioning on conditioned pain modulation and heart rate variability in knee osteoarthritis

Conditions: Ischemic Preconditioning

Summary: introduction: musculoskeletal disorders have affected approximately 1.3 billion people worldwide. evidence shows that chronic diseases and musculoskeletal conditions often occur together, and among them it is estimated that more than 240 million people worldwide have symptomatic osteoarthritis (oa) and activity limitation, which is a major contributor to chronic pain and changes central in pain processing. it is known that physical exercise (active approach to treatment) and manual therapy (passive approach) are capable of intervening in the pain processing system, but passive approaches have been little investigated. among them, little is known about the effect of ischemic preconditioning (ipc) for pain management and its impact on conditioned pain modulation (cpm) and cardiac autonomic control. there is no evidence that ipc causes systemic hypoalgesia and increased vagal modulation, so this provides a rationale for study. objectives: to analyze the acute effect of ipc on local pain, cpm and cardiac autonomic control in women with knee oa and observe whether there is a correlation between them. methods: double-blind, placebo-controlled, randomized clinical trial. participants will be divided into ipc or placebo groups. outcomes evaluated: cpm and cardiac autonomic modulation. comparisons will be performed using generalized mixed linear models fitted to the data. for correlation, the pearson or spearman correlation test will be used according to the normality of the data. all analyzes will assume a significance level of p\<0.05.


Eligibility criteria:
inclusion criteria: * medical diagnosis for uni or bilateral oa of the tibiofemoral joint (grade ii or superior kellgren-lawrence radiographic changes); * not having systemic rheumatic diseases such as fibromyalgia, rheumatoid arthritis, systemic lupus erythematosus; * not having total knee arthroplasty, knee ligament injury, history of knee surgery; * not having heart disease, congestive heart failure, or a history of acute myocardial infarction (except those with hypertension); * not having diagnosis of neurological, metabolic, endocrine disorder, respiratory disease; * not being an alcoholic or smoker; * not use drugs that influence cardiac autonomic modulation (beta-blocker); * not having one or more predisposing risk factors for thromboembolism. exclusion criteria: * use anti-inflammatory drugs or analgesics 24 hours before the test; * perform physical activity; * consume alcohol; * perform therapeutic treatments for pain relief; * errors in capturing the rr intervals; * want to leave the study.

Keywords: ischemic preconditioning therapeutic occlusion conditioned pain modulation heart rate variability autonomic nervous system osteoarthritis chronic pain
comparison between robotic-arm assisted total knee replacement and traditional total knee replacement

Conditions: Osteoarthritis, Knee

Summary: this is a multicenter, prospective, and case-control study. five joint centers and 100 participants will be included. the study group used robotic-assisted modified kinematic alignment total knee replacement, and the control study used traditional alignment manual total knee replacement. the knee society score (kss), hip-knee-ankle(hka) angle, mechanical lateral distal femoral angle(mldfa), mechanical medial proximal tibial angle(mmpta), sagittal femoral component angle(sfca), range of motion(rom), womac score, sf-36, visual analogue scale(vas score), surgical time, blood loss, and complications are evaluated and compared.


Eligibility criteria:
inclusion criteria: * age between 18 years and 85 years * primary total knee replacement exclusion criteria: * obvious bone defect * infection * bmi\>\>35kg/m2 * severe osteoporosis * mental disease

Keywords: robotic-arm assisted total knee replacement kinematic alignment
cold plasma to treat hair loss

Conditions: Androgenetic Alopecia

Summary: self applied cold plasma activated medium used for androgenetic alopecia


Eligibility criteria:
inclusion criteria: * diagnosis of mild-to moderate androgenetic alopecia * ability of applying treatment regularly * ability to keep in-person follow-up appointments exclusion criteria: * any inflammatory scalp condition * starting or discontinuing any hair loss treatments within 6 months of start date * allergy to any components of the carrier solution
food and alcohol behavior study: meaningful enhancement

Conditions: Folate Deficiency

Summary: this study will determine how folate supplementation affects both serum and red blood cell folate status in females ages 18 -24 years old. additionally, this study will determine the effect of folate supplementation on mood, cognition, and sleep patterns. this study will fill a crucial gap in understanding how folate status affects a variety of health behaviors in order to better inform public health practice and prevention.

preliminary studies conducted by the investigator's team indicate that 95.7% of previous participants (all alcohol consuming, ages 14-24), were below the threshold for red blood cell (rbc) folate status for women of childbearing potential. understanding how the interaction of behaviors (alcohol use, nutrient supplementation, diet) contribute to sub-optimal folate status is critical to developing and expanding upon evidence-based fasd prevention programs. notably, how nutrient supplementation might improve overall folate status in a group with poor folate status and other behaviors that confound the absorption of folate. because the participants do not view themselves as being at risk for unwanted pregnancy, their motivation to take a supplement for a future pregnancy is very low. this team seeks to collect data on how folate supplementation might improve individually measured outcomes, like cognition and mood, so that interventions might be developed focusing on these individual outcomes. after becoming aware of the study, prospective participants will undergo a screening questionnaire for inclusion/exclusion criteria. once the participant meets the inclusion criteria, the study will be fully explained and written informed consent will be handed out. participants will be randomized in a single-blind manner (participant) in a 1:1 ratio to the methyl folate supplement (1,000 mcg, once daily) or placebo (once daily).

Eligibility criteria:
inclusion criteria: * females restricted to those living in the united states * not currently using hormonal birth control * must experience menses * must begin the study exactly one week after the start of their menstrual cycle * folate consumption must be less than or equal to 250 micrograms of dietary folate equivalents (dfes) exclusion criteria: * current use of a folate supplement
normal parameters of cranial vessels using cranial vascular duplex among egyptian population

Conditions: Atherosclerosis; Atheroma of Cerebral Arteries; Atheroma; Carotid Artery; Atheroma; Cerebral

Summary: the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the egyptian population.

atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. in the united states and western communities, extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. little is known about the prevalence and distribution of carotid disease among the populations in the developing countries. vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in mri machines, and has much less risks compared to conventional angiography studies. although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations. the parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.

Eligibility criteria:
inclusion criteria: * normal subjects between 20-40 years exclusion criteria: * diabetic patients, hypertensive patients, any evidence of vascular disease either peripheral or central, subjects refusing to participate

Keywords: cranial vessels normal parameters carotid duplex egyptian
evaluation of the sarcopenia in hepatobiliary surgery

Conditions: Sarcopenia; Hepatobiliary Disease; Postoperative Complications; Surgery

Summary: the sarcopenia is defined as a loss of muscle mass and a loss of muscle function ( strength or performance). some studies showed that the sarcopenia increase the postoperative complications and the overall survival in abdominal surgery. but the sarcopenia is not evaluated in the hepatobiliary surgery. this prospective, monconcentrique study aim to evaluate the prevalence of sarcopenia, and its associated morbimortality in hepatobiliary surgery for malignant or benign tumors.


Eligibility criteria:
inclusion criteria: * hepatobiliary surgery * scheduled surgery * oral consent exclusion criteria: * pregnancy * patient under low protection * emergency surgery * hepatic encephalopathy stage ii, iii and iv
effects of transcranial direct current stimulation on pain control in chronic painful total knee arthroplasty

Conditions: Pain, Chronic

Summary: the tsef-ptg study aims to evaluate the effects of transcranial direct current stimulation (tdcs) and exercise versus sham tdcs (placebo) and exercise on pain control in chronic painful total knee arthroplasty (tka) patients.

the tsef-ptg study is a single center, double blinded randomized controlled trial. the aim is to evaluate the effects of a tdcs stimulation and exercise vs sham tdcs and exercise on pain control in chronic (lasting more than 3 months from the intervention) painful total knee arthroplasty (tka) patients. the participants will be randomized in two groups: intervention group (ig) and control group (cg). the ig will receive a 20 minute program of active tdcs (2ma intensity, anode placed on primary motor cortex controlateral to the tka, cathode placed on controlateral supraorbital region) followed by a 30 minute exercise program, 5 days a week, for 2 consecutive weeks. the cg will receive a 20 minute program of sham tdcs (15 seconds of activation and then no stimulation, same position of ig) followed by the same 30 minute exercise program, 5 days a week, for 2 consecutive weeks. the participants will be evaluated at t0 (enrolling), t1 (at the end of the program), t2 (at 1 month from the end of the program) and t3 (at 3 months from the end of the program). the primary outcome is the variation of pain intensity, the secondary outcomes are the variation of knee function and of the quality of life.

Eligibility criteria:
inclusion criteria: * signed informed consent * able to independently walk (with or without walk aids) * chronic painful tka (more than 3 months) * visual analogic scale for pain more than 3/10 * no cognitive impairments (mmse\>24 or =24/30) exclusion criteria: * intracranial metal devices, pacemakers or any implantable devices * cutaneous abnormalities on the stimulation sites * epilepsy (past or present) * neurological or psychiatric pathologies * cognitive impairment (mmse\<24/30) * no opioids abuse (past or present) * severe cardiopulmonary, renal or hepatic pathologies * pregnancy * known present tka complications (e.g. infections, mobilization, etc...) * pain therapy modifications in the last 1 month

Keywords: total knee arthroplasty chronic pain transcranial direct current stimulation