Kornimate/medical-research-clean huggingface dataset:
study evaluating paz-417 in healthy young/elderly

Conditions: Alzheimer Disease

Summary: this study is to evaluate the safety and tolerability of single, ascending doses of paz-417 in healthy young and healthy elderly subjects. the effect of a high fat meal on the metabolism of paz-417 will also be studied, along with blood levels of paz-417 . changes in cognitive function will be assessed.


Eligibility criteria:
inclusion criteria: 1. men or women, aged 18 to 50 years inclusive (healthy young subjects) and \> 65 years inclusive (elderly subjects) on study day 1. women of nonchildbearing potential may be included if they are either surgically sterile (hysterectomy and/or oophorectomy) or postmenopausal for ≥1 year (with estradiol ≤25 pg/ml\[92 pmol/l\] and fsh ≥40 miu/ml) and must have a negative serum pregnancy test result within 48 hours before administration of test article. women who are surgically sterile or post-menopausal must provide documentation of the procedure by an operative report or by ultrasound and have a negative serum pregnancy test result within 48 hours before administration of test article. 2. the elderly subjects must be generally healthy, but may be enrolled with a stable, chronic illness, if it is well-controlled, and does not interfere with the primary objective of the study. subjects may be included with clinically important deviations from normal limits in medical history, physical examination, vital signs, 12-lead ecgs, or clinical laboratory test results which are associated with stable, chronic, well-controlled, medical conditions. 3. the estimated creatinine clearance must be within the age-appropriate normal range. exclusions criteria: 1. presence or history of any disorder that may prevent the successful completion of the study. 2. any surgical or medical condition that may interfere with the absorption, distribution, metabolism, or excretion of the test article. 3. exclude subjects with a history of vascular disorders (peripheral, coronary, venous), chronic inflammatory disorders (e.g., rheumatoid arthritis), hematologic disorders, and bleeding disorders (e.g., hemophilia, idiopathic thrombocytopenic purpura, von willebrand's disease).

Keywords: healthy safety
patient-led surveillance compared to clinician-led surveillance in people treated for localised melanoma.

Conditions: Melanoma (Skin)

Summary: the purpose of this pilot study is to evaluate digitally supported skin self-examination compared to usual care in people treated for localised melanoma.

patients may be eligible to join this study if they are aged 18 years or above, have been treated for stage 0/i/ii melanoma and are attending regular melanoma surveillance follow-ups at the melanoma institute australia (mia), royal prince alfred hospital (rpah) or the newcastle skin check clinic. people who are found to be eligible and who consent to participate will be randomised (allocated by chance) to the intervention or usual care in a 1:1 ratio. usual care group will receive an educational booklet on early melanoma and the usual number of routine clinic visits. in addition to usual care, participants allocated to the intervention group will be required to download a skin checker app to their smartphone and will use a mobile dermatoscope to perform total body skin self-examinations every 2 months for 6 months in total. email and sms reminders will also be sent every two months to participants in the intervention group. participants will be documented on how well they are able to perform a self skin examination, their levels of melanoma-related anxiety, the number of skin lesions biopsied or removed, and the costs of follow-up to the participant and to the healthcare system. frequent follow-up of localised melanoma is time and resource intensive, and has not shown improved outcomes. this pilot study will provide evidence on which model is best for follow-up care after treatment for localised melanoma.

Eligibility criteria:
inclusion criteria: * patients treated for stage 0/i/ii melanoma and are attending regular melanoma follow-up as indicated by scheduled visit within next 12 months in clinic patient booking system and * are able to self-examine; * have a suitable study partner (spouse, partner, family member, friend); * have a smart phone with access to wifi / email / sms text messaging; * are able to give informed consent ; * have sufficient english language skills to read the materials and complete the questionnaires; exclusion criteria: * unable to perform self-examination * no partner or friend to help with self-examination * do not have access to a smart phone with wifi/email/sms text messaging * with a known past or current diagnosis of cognitive impairment
effect of online education given to young adults on testicular cancer health beliefs and behaviors

Conditions: Testicular Neoplasms

Summary: aim: one of the cheapest, easiest and most effective ways to detect testicular cancer early is to resort to early detection screening methods associated with health beliefs about testicular cancer, and the second is to self-examine the testicles. in the country, there are a limited number of studies on the health beliefs and early diagnosis behaviors of young adult men for testicular cancer. for this reason, the study was conducted to determine the effect of online education given to young adults on testicular cancer health beliefs and behavior. material and method: the research was conducted as a randomized controlled experimental study. the study population consisted of 768 individuals who applied to family health centers affiliated to agri provincial health directorate between april 2021 and june 2022, and the sample of the research consisted of 90 individuals selected from the population using the improbable random sampling method. "descriptive feature form", "champion's health belief model scale in testicular cancer screenings" were used to collect data. in the analysis of data; percentile distribution, chi-square, fisher-freeman-halton exact test, t-test in independent groups, repeated measures anova test, friedman test, one way anova test, kruskall wallis test, and post hoc analyzes (bonferroni, games howell, dunn) were used.


Eligibility criteria:
inclusion criteria: * being 18-35 years old, * being literate, * computer can be used, * being able to access the internet, * not having a testicular diagnosis before, * deciding to participate in the research. exclusion criteria: * being outside the age range of 18-35, * to be diagnosed with testicular cancer before

Keywords: health belief model health behavior education, distance testicular neoplasms
an expanded access study of oral liquid efavirenz in the treatment of children with hiv infection: canada

Conditions: HIV Infection

Summary: this study is being conducted to assess the safety and tolerability of an oral liquid solution of sustiva for antiretroviral therapy-naive or therapy-experienced hiv-1 infected children between the ages of 3-16 who are failing or intolerant of their current antiretroviral regimen and who are unable to swallow sustiva capsules.


Eligibility criteria:
inclusion criteria: * children 3-16 years of age * anti-retroviral naive or experienced * failing or intolerant to current anti-retroviral (arv) regimen * limited available viable therapeutic options * inability to take capsules/tablets exclusion criteria: * weighs less than 10 kg * failure on or concomitant use of other non-nucleoside reverse transcriptase inhibitors (nnrtis) * an active aids-defining opportunistic infection or disease * more than two episodes of moderate to severe diarrhea or vomiting lasting more than four days within the past three months
study of top1630 for dry eye syndrome

Conditions: Dry Eye Syndrome

Summary: in subjects with dry eye syndrome (des): the primary objective of this study is to confirm the efficacy of top1630 0.1% ophthalmic solution tid ou compared to placebo treatment at day 29 on pre-specified sign and symptom endpoints in subjects with moderate to severe des.

this study is designed to assess the efficacy and safety of top1630 ophthalmic solution in subjects with dry eye syndrome (des). eligible subjects will be randomized double masked to either top1630 or placebo for a duration of 28 days' treatment.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age; * provide written informed consent; * have a reported history of dry eye; * have a history of use of eye drops for dry eye symptoms; symptoms of dry eye syndrome including: * ocular discomfort * conjunctival redness * tear film break up time * schirmer test score signs of dry eye syndrome including: * conjunctival staining score exclusion criteria: * have any clinically significant slit lamp findings at entry visit ; * be diagnosed with an ongoing ocular infection; * have any significant ocular lesion that could interfere with assessment of safety or efficacy or prevent study conduct in the opinion of the pi; * have any planned ocular and/or lid surgeries over the study period; * have an uncontrolled systemic disease; * be a woman who is pregnant, nursing or planning a pregnancy; * be a woman of childbearing potential who is not using an acceptable means of birth control; * have a known allergy and/or sensitivity to the test article or its components; * have a condition or be in a situation which the investigator feels may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study
the comparison of voice quality in early laryngeal cancer between surgery and radiotherapy

Conditions: Voice Quality

Summary: early laryngeal cancer is a well known field with great controversy in treatment. two options are available in treatment of patients the first one is partial laryngectomy and the second one is radiotherapy.one of major concern of patients have been the quality of voice ,so we design this trial to answer the priority of each options.

early laryngeal cancer is a well known field with great controversy in treatment. two options are available in treatment of patients the first one is partial laryngectomy and the second one is radiotherapy.one of major concern of patients have been the quality of voice as part of quality of life ,so we design this clinical randomised trial to answer the priority of each options.

Eligibility criteria:
inclusion criteria: * early laryngeal cancer exclusion criteria: * no history of radiotherapy and collagen vascular disease

Keywords: laryngeal cancer radiotherapy voice quality
evaluation of anatomical results and sexual functions after unilateral and bilateral laparoscopic suture sacro-hysteropexy operations

Conditions: Pelvic Organ Prolapse

Summary: the study was planned as prospective and randomized. for the study, patients will be randomized into two groups as unilateral and bilateral suture sacro-hysteropexy operations.

the study was planned as prospective and randomized. for the study, patients will be randomized into two groups as unilateral and bilateral suture sacro-hysteropexy operations.computerized random number table will be used as randomization method. patients who agree to participate in the study and fulfill the inclusion criteria will be evaluated on the effects of prolapse on quality of life and sexual function before and after the surgical procedures and their complaints and satisfaction will be questioned. surgical success and complications will be evaluated. changes in the level of prolapse will be evaluated.

Eligibility criteria:
inclusion criteria: 1. patients between the ages of 18-60 2. no previous prolapse surgery 3. not having a chronic disease 4. having stage 3-4 prolapse exclusion criteria: 1. outside the age range of 18-60 years 2. previous prolapse surgery 3. having early stage (1-2) prolapse 4. history of chronic disease

Keywords: suture sacro hysteropexy pelvic organ prolapse
improving transition care for adolescents and young adults with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: the purpose of this research study is to evaluate a transition preparation program designed for adolescents and young adults (ayas) with type 1 diabetes (t1d). this transition program will support ayas as they prepare to transition from pediatric to adult endocrinology medical care and will also include a caregiver. results from this study will inform clinical recommendations regarding self-management best practices for ayas with t1d prior to transitioning to adult medical care.

investigators will recruit adolescents and young adults ages 16-22 years with t1d and a parent/guardian. families will participate in one of two 6-month treatments: 1) shift2, engaging in monthly sessions with transition coaches providing education on diabetes management and healthcare transition, or 2) enhanced treatment (tau+), engaging in routine medical care and receiving monthly education (no coaches).

Eligibility criteria:
inclusion criteria: aya: 1. type 1 diabetes diagnosis for at least 1 year (as documented in medical record) 2. 16-22 years old 3. english speaking 4. children's hospital of richmond patient (division of pediatric endocrinology) 5. must have a caregiver willing to participate caregiver: 1. age greater than 18 years 2. provides care to aya and willing to participate exclusion criteria: aya: 1. non-english speaking 2. significant psychiatric, cognitive, medical or developmental conditions that would impair their ability to complete assessments and/or engage in diabetes self-care behaviors (e.g., malignancies, psychosis, intellectual disability 3. hospitalization for depression, suicidal ideation or other psychiatric disorder within the past 12 months. life time history of psychotic disorder 4. medically-induced diabetes or diagnosis of diabetes other than type 1 diabetes. 5. currently pregnant, pregnant within the past 6 months, currently breastfeeding or planning to become pregnant within the next 12 months. 6. another member of the household (other than the participating parent) is a participant or staff member on this study. 7. participation in another research study that may interfere with this study. 8. previous participation in the shift pilot study caregiver: 1. non-english speaking 2. significant psychiatric, cognitive, developmental conditions that would impair their ability to complete assessments and/or engage in supporting the aya with diabetes self-care behaviors (e.g., psychosis, intellectual disability) 3. another member of the home (not aya) is a participant/staff member on current study 4. participation in another research study that may interfere with current study 5. previous participation in shift pilot study

Keywords: diabetes management transition
a virtual-reality based approach to improve behavioral weight management outcomes

Conditions: Weight Loss

Summary: a pilot randomized trial was done to test the feasibility integrating virtual reality (vr) into standard behavioral weight loss treatment.

participants with overweight or obesity are randomly assigned to a 4-week standard behavioral weight loss plus non-weight-related vr app (i.e., control group) or standard behavioral weight loss plus weight-related vr app (i.e., intervention group). the intervention's vr tool was designed to enable practice of behavioral skills taught in weekly group meetings, including managing social and home environmental cues for eating and activity.

Eligibility criteria:
inclusion criteria: non-pregnant adults (age \> 18 years) overweight or obesity (bmi ≥ 25) able to speak and read in english. available on thursday evenings have an iphone 6 or higher exclusion criteria: self-reported serious psychological problems or medical problems
anti-inflammatories and adolescent schizophrenia

Conditions: Schizophrenia

Summary: a double-blind controlled trial assessing the efficacy of anti-inflammatories on symptoms and cognition of adolescents with schizophrenia

patients will be evaluated to confirm the diagnosis of schizophrenia, duration of the disease and record a history of atopic diseases or recurrent infections throughout life. the panss, psp, and mccb battery scales will be administered. a blood sample will be taken for the determination of markers of inflammation before the start of pharmacological treatment. patients will start the antipsychotic medication assigned by their treating physician. they will also be assigned randomly to the treatment arm. the study drug will be provided by the research team under the presentation of capsules containing celecoxib 200 mg, minocycline 100 mg or placebo, and patients will be instructed to take one capsule every 12 hrs daily. the patient will be reassessed with panss, psp, and mccb after completing 6 weeks of pharmacological treatment, type and dose of medication will be recorded and serum markers of inflammation will be determined again.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or schizophreniform disorder. * patients in their first psychotic episode or previously diagnosed * no specific pharmacological treatment (antipsychotic at therapeutic doses in regular doses) in the previous two weeks. * have a responsible parent or guardian. exclusion criteria: * active infection * chronic somatic diseases, including autoimmune diseases * comorbidity with anorexia, substance use disorders * pregnancy * use of anti-inflammatory medications or antibiotics

Keywords: schizophrenia adolescents inflammation anti-inflammatory
early mobilisation after surgery in patients with elbow fracture-dislocation

Conditions: Early Mobilization; Elbow Stiffnes; Elbow Fracture

Summary: the purpose with the study is to evalute if early mobilsation after surgery in patients vid elbow frakture-dislocation may lead to better armfunction and reduce common complications as stiffnes in the elbow. after surgery patients will be randomised to either early mobilisation (exercise treatment 3 days after surgery) or ordinary treatment (plaster and exercise treatment 3 weeks after surgery).

in patients with elbow fracture in combinations with dislocation, surgery is often indicated. after surgery the ordinary standard praxis treatment is immobilisation in a plaster for 3 weeks. one common complication is "stiff elbow". stiffness in the elbow may be due to "heterotopic ossification" which is the abnormal growth of bone in the non-skeletal tissues including muscles or tendons. there is a prospective study that have reported positive results with early mobilisation starting two days after surgery in these patients. however, randomised clinical trials are missing. therefore our aim was to investigate if early mobilisation may increase elbow function (increased range of motion and decreased pain) and also reduce comlications as stiff elbow compared to ordinary treatment in these patients. all patients operated with elbow fracture-dislocation at the university hospital in linköping were asked if the wanted to participate in the study. they had thourough written and oral information about the study. if they agree to participate written informed consent was collected. after surgery patients were randomised to either early mobilisation or to ordinary treatment (standard praxis). at baseline before surgery or directly after patients filled in some background vatiables such as gender, age social status medical treatment etc they also filled in some self-adminstrated outcome measure in purpuse to evalute upper extremity function and activity and health related quality of life. follow ups with x ray and upper extremity function and activity were at 3 weeks 3 and 12 months with an independent observer. in beteween these follow ups patient followed the treatment regime (ordinary or early exrecise treatment) and had support from a physiotherapist.

Eligibility criteria:
inclusion criteria: patients over 18 years with elbow fracture-dislocation being operated on. - exclusion criteria: * ongoing cancer and earlier radiation therapy in the study arm * neurological disease * cervcialgia or disc herniation in the neck * associated nerv or blodvessel injury * dementia

Keywords: upper extremity function elbow stiffnes early mobilization
covid-19 pandemic: perception, attitude

Conditions: COVID-19 Pandemic

Summary: : adherence to preventive control measures is influenced by perception, attitudes and practices toward the disease prevention.

methods study design: a cross-sectional survey study was utilized in which data were collected following the checklist for reporting results of internet e surveys (cherries) guidelines during the period from march to july2021. study settings and participants the study conducted through an electronic anonymous online survey distributed among students from three health sector faculties (medicine, pharmacy, and nursing) in six egyptian universities (cairo, suez canal, tanta, daria, aswan, kufr elsheikh). the self-administered online questionnaire was hosted in google form and the link was distributed through official university platforms and informal student groups on social media like facebook and whatsapp pages. representatives of students were also engaged in distributing the questionnaire's link directly to their colleagues from each faculty. a non-randomized convenient sample of 1900 university medical students was included in the study. data collection the study questionnaire was developed based on the covid-19 rapid quantitative assessment tool as part of the risk communication and community engagement (rcce) action plan guidance covid-19 preparedness and response developed by the china international famine relief commission publication, united nations children's fund (unicef) and world health organization (who) \[14\]. most of the questions were in the form of "yes and no" questions except for a few questions with the third "i don't know" option, a five-point rating scale question. after the tool was developed, the application was tested by the eyi (egyptian youth initiative) executive team at the national population council (npc)/unicef to verify, confirm and skip patterns and follow them to guarantee the accuracy of data collection. to ensure the validity and accuracy of the data collected, the investigators settle detailed instructions regarding study objectives for all student counselors who distributed the questionnaire to the subjects in advance. the survey tool automatically verifies that all questions must be filled before submission and cannot be submitted twice.

Eligibility criteria:
inclusion creteria university students from health sector faculties exclusion criteria: -