Kornimate/medical-research-clean huggingface dataset:
lci in chronic atrophic gastritis and early gastric cancer

Conditions: CAG - Chronic Atrophic Gastritis; EGC - Early Gastric Cancer

Summary: color change is a useful marker for the endoscopic identification of chronic atrophic gastritis (cag) and gastric cancer (gc). several histopathological studies have suggested a correlation between certain gastrointestinal lesions and intramucosal vascularity. the aim of this study is to investigate the association between the color and mucosal microvascular density of cag and early gc using linked color imaging (lci). in this study, lesions diagnosed as cag and early gc will be observed using lci. in each image, the color values of atrophic and non-atrophic mucosa, as well as cancerous and non-cancerous mucosa, will be quantified using the international commission on illumination 1976 (l∗, a∗, b∗) color space. histological microvascular density in biopsy or resected specimens will be evaluated using cd31 immunostaining. color differences at the atrophic border and cancerous border, defined as euclidean distances of color values between the atrophic and non-atrophic mucosa, as well as cancerous and non-cancerous mucosa, will be calculated according to mucosal microvascular density.

in this study, 10 patients diagnosed with cag or early gc by esophagogastroduodenoscopy at fifth medical center of chinese pla general hospital between september 2023 and december 2023 will be enrolled. the following equipment will be used for the study: lci endoscope (eg-760z, fujifilm co., tokyo, japan), light sources (lasereo ll-4450; fujifilm co.), and video processors (advanciahd vp-4450hd; fujifilm co.). during esophagogastroduodenography, the atrophic or cancerous border will be identified. following identical compositions, images will be continuously captured via lci. endoscopic biopsy or resection will be performed, and the mucosal microvascular density will be histopathologically analyzed using the specimens. the color values of atrophic and non-atrophic mucosa, as well as cancerous and non-cancerous mucosa, will be quantified using the international commission on illumination 1976 (l∗, a∗, b∗) color space. histological microvascular density in biopsy or resected specimens will be evaluated using cd31 immunostaining. color differences at the atrophic border and cancerous border, defined as euclidean distances of color values between the atrophic and non-atrophic mucosa, as well as cancerous and non-cancerous mucosa, will be calculated according to mucosal microvascular density.

Eligibility criteria:
inclusion criteria: * patients diagnosed with chronic atrophic gastritis (cag) and early gastric cancer (egc). by esophagogastroduodenoscopy exclusion criteria: * inappropriate lci images as a result of bleeding, ulceration, or excessive mucosal congestion * patients with severe anemia or portal hypertension * patients diagnosed as having a mixture of the differentiated and undifferentiated types of gastric carcinoma, or having helicobacter pylori infection

Keywords: color information linked color imaging mucosal microvascular density chronic atrophic gastritis early gastric cancer
a study to evaluate the safety and efficacy of ccx140-b in subjects with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the safety and potential effectiveness of ccx140-b in subjects with type 2 diabetes mellitus.

the primary objective of this study is to evaluate the safety and tolerability of ccx140-b in subjects with type 2 diabetes mellitus (t2dm) based on subject incidence of adverse events. the secondary objectives of this study include evaluation of the effect of ccx140-b on several measures of effectiveness commonly used in the evaluation of diabetes medications. study acquired by amgen and all disclosures were done by previous sponsor chemocentryx.

Eligibility criteria:
key inclusion criteria: * diagnosed type 2 diabetes mellitus * must have a body mass index ≥25 and \ 94 cm for men and \>80 cm for women * must be on a stable dose of metformin for at least 8 weeks prior to randomization * hemoglobin a1c (hba1c) of 6.5 to 10.0% inclusive and fasting plasma glucose 135 to 270 mg/dl inclusive at screening key exclusion criteria: * type 1 diabetes mellitus or history of diabetic ketoacidosis * received insulin treatment within 12 weeks of randomization * received chronic (more than 7 days) systemic glucocorticoid treatment within 12 weeks of randomization * received sulfonylurea, thiazolidinedione, exenatide, or any other glucose lowering treatment (other than metformin) within 8 weeks of randomization * symptomatic congestive heart failure requiring prescription medication, clinically evident peripheral edema, poorly-controlled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100), history of unstable angina, myocardial infarction or stroke within 6 months of randomization, or chronic renal failure * history or presence of drug-induced myopathy, drug-induced creatine kinase elevation, or leukopenia (wbc count \<3.5 x 10(9)/l) * history or presence of any form of cancer within the 5 years prior to randomization, with the exception of excised basal cell or squamous cell carcinoma of the skin, or cervical carcinoma in situ or breast carcinoma in situ that has been excised or resected completely and is without evidence of local recurrence or metastasis * fasting serum triglyceride \>400 mg/dl
central corneal thickness with sensimed triggerfish

Conditions: Glaucoma; Ocular Hypertension

Summary: investigation of the occurrence of possible corneal swelling after continuous intraocular pressure (iop) monitoring with a contact lens-based sensor during the sleeping period.


Eligibility criteria:
inclusion criteria: * glaucoma and ocular hypertension scheduled for overnight hospitalisation * stable iop-lowering treatment since at least 4 weeks before study * at least 18 years * having provided informed consent exclusion criteria: * contact lens wear within the last 2 years * contraindication for silicone lean wear * corneal abnormality in either eye * ocular infection or inflammation * history of ocular surgery within the last 3 months * full-frame metal glasses during iop monitoring with sensimed triggerfish * pregnancy and lactation * patients not able to understand the nature of the research * patients under tutelage * patients committed to an institution by virtue of an order issued either by the courts or by an authority * simultaneous participation in other clinical research
effect of neostigmine on the recovery of rocuronium: a comparison between partial and tof ratio-based dose

Conditions: Muscle Relaxant; General Anesthesia

Summary: this study aimed to evaluate the effect of neostigmine partial dose towards neuromuscular blockade of rocuronium

approval from ethical committee of faculty of medicine university of indonesia was acquired prior conducting the study. subjects were given informed consent before enrolling the study and randomized into two groups. intravenous (iv) cannula with ringer lactate fluid, non-invasive blood pressure monitor, electrocardiogram (ecg) and pulse-oxymetry were set on the subjects in the operation room. after preoxygenation was given with 100% oxygen, general anesthesia induction was done with midazolam 0.01-0.02 mg/kg, fentanyl 3 mcg/kg, propofol 1-2 mg/kg, and rocuronium 0.6 mg/kg. following induction, endotracheal intubation or laryngeal mask insertion was performed. maintenance was done by sevoflurane 1.2 vol%, and fentanyl 1.2 mcg/kg. after the surgery had finished, fentanyl drip was stopped. subjects were then observed until spontaneous breaths occured adequately (tidal volume ≥ 5 ml/kg) before train of four (tof) ratio was evaluated using acceleromyography (amg). before reversal (neostigmine) was given, anesthetic gas was stopped and duration of operation as well as post-operative tof ratio was recorded. the time since reversal was given then recorded. group a received neostigmine partial dose (0.02 mg) in combination with atropine 0.4 mg for every milligram of neostigmine. group b received tof ratio-based dose of neostigmine in combination with atropine 0.4 mg for every milligram of neostigmine. after administration of neostigmine, tof ratio was measured every 5 minutes until tof ratio of ≥ 90% was achieved, and finally definitive airway could be removed. for group a, another partial dose of neostigmine was given after 10 minutes from the first reversal dose if the tof ratio of ≥90% had not been reached. for group b, another tof ratio-based dose of neostigmine was given after 10 minutes from the first reversal dose if the tof ratio of ≥90% had not been reached. subjects were then transported to recovery room. data was analyzed using statistical package for the social sciences (spss), for numerical data using unpaired t-test or mann-whitney-u test, for categorical data using chi-square test or fischer exact's test. data normality was tested by kolmogorov-smirnov test. significant value is p\<0.05.

Eligibility criteria:
inclusion criteria: * patients aged 18-60 years old * american society of anesthesiologists (asa) physical status i-ii who were planned to undergo any elective surgery at operating room in general anesthesia * subjects had been explained about the study, and agreed to enroll and have signed the informed consent form exclusion criteria: * bmi ≥ 30 * had any severe kidney or liver disease * had neuromuscular disease or asthma drop out criteria: * duration of operation less than one hour or more than 2 hours * during surgery received maintenance dose of neuromuscular block * intraoperative cardiac arrest was occurred
anticoagulation therapy in the very old

Conditions: Atrial Fibrillation

Summary: this study is designed to evaluate the efficacy and safety of warfarin anticoagulation in the very old and attempt to identify risk factors which may impede safe and effective anticoagulation.

this is a prospective registry study with data being collected continuously for 24 months. patients who have electrocardiographically confirmed atrial fibrillation, are being followed by the pen bay medical center anticoagulation services and are at least 90 years old will be recruited into the study. a matched cohort of patients between the ages of 80 and 89 and another matched cohort of patients between the ages of 70 and 79 will also be recruited into the study for comparison. data related to adverse events, concomitant medications, living arrangements, mobility and alcohol use will be collected every 6 months. in addition the cha2ds2-vasc (score for atrial fibrillation stroke risk), has - bled (major bleeding risk score for patients on anticoagulation), frailty and mini cog scores will be recalculated at each visit.

Eligibility criteria:
inclusion criteria: * 70 years of age or older * electrocardiographically confirmed atrial fibrillation * anticipated regular follow up with patient by penobscot bay medical center (pbmc) anticoagulation services * subject or legally authorized representative must be willing to provide informed consent exclusion criteria: - patients not being followed by the pbmc anticoagulation services

Keywords: elderly anticoagulation risk assessment
web-based intervention for lung cancer patients and their informal caregivers

Conditions: Non-Small Cell Lung Cancer

Summary: the purpose of this study is to find out if patients with lung cancer and their main informal caregiver (person providing physical, emotional, or financial support) are helped by getting information, support, and decision making tools through a computer system called chess(the comprehensive health enhancement support system)

many patients and their family/friends use the internet for obtaining information regarding the cancer diagnosis and treatment. in this study, the main caregiver of patients with advance (stage iii or iv) non-small cell lung cancer is provided with a computer and internet access. approximately one-half of the participants will also receive chess.

Eligibility criteria:
inclusion criteria: * advanced non-small cell lung cancer (stage iii or stage iv) * needs to have a "caregiver" - a spouse, partner, family member, or friend providing emotional, physical, and/or financial support - to participate with the patient.

Keywords: lung cancer, caregivers, support, resources, education
evaluation of effects of clavicular hook plate on subacromial space

Conditions: AC Joint Dislocation

Summary: in this study, the investigators intend to demonstrate that the hook plate may have adverse effects on subacromial structures even with a short period of hardware retention. the investigators also sought to determine if musculoskeletal sonography could be used as a tool to demonstrate shoulder pathology such as subacromial impingement or rotator cuff tear in patients receiving hook plate fixation. the clinical results of patients receiving hook plate fixation, specifically bony union, pain relief, shoulder function and range of motion (rom), were also evaluated.


Eligibility criteria:
inclusion criteria: * the patient received surgical treatment for ac joint dislocation of unstable distal clavicle fracture in our hospital from december 2007 to january 2009. exclusion criteria: * the patient who was expired or the injured limb has preexisting injury or neurological deficit.
clairity in a university mental health clinic

Conditions: Depression; Anxiety; Suicide; Mental Health Issue

Summary: this is a clinical trial to evaluate the effectiveness of the clairity tool within the university setting for students who are being seen by a mental health provider.

in this study, the investigators plan to evaluate the effect of the clairity process in a university setting. the clairity process will be implemented as a 15-20 minute "between-the-visit" mental health check-in between a patient and clinical staff. clairity will record and analyze patient speech using artificial intelligence algorithms developed for early detection and monitoring of mental health and suicidal risk. this study will be the first to return clairity results real time to the clinician. the study employs a mixed-methods design, using rolling recruitment of clients of the xavier university psychological services clinic (xups) during the 2022-2023 school year. study-trained clinical research coordinators will begin enrolling participants after completing the online protocol training and brief human subject's protection training.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * currently a client receiving services from xups * able to provide informed consent * speaks and understands english fluently * willing to abide by all research procedures exclusion criteria: * participants with communication disorders (linguistic or articulation) or who cannot articulate clearly in english. * participants with an intellectual and/or neurocognitive disability that the study staff deems a barrier to participation. * history of any other serious medical or psychiatric condition that would interfere with the ability of the patient to complete the study or would make it ethically unfeasible to enroll. * any participant, who at the discretion of the study staff, should not be enrolled.
an investigational immuno-therapy study of ulocuplumab in combination with low dose cytarabine in patients with newly diagnosed acute myeloid leukemia

Conditions: Leukemia

Summary: the purpose of this study is to determine the safety and effectiveness of ulocuplumab in combination with low dose cytarabine in the treatment of newly diagnosed acute myeloid leukemia (aml).


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * newly diagnosed acute myeloid leukemia (aml) * considered inappropriate for intensive remission induction therapy by an investigator * not eligible for stem cell transplantation exclusion criteria: * acute promyelocytic leukemia * current myelodysplastic syndrome only subjects * unstable angina or uncontrolled congestive heart failure * any other malignancy, excluding basal or squamous cell carcinoma of the skin, in situ melanoma, cervical carcinoma in situ, localized prostate cancer, or superficial bladder cancer stage 0, from which the subject has not been disease-free for at least 3 years * respiratory disease requiring continuous supplemental oxygen other protocol defined inclusion/exclusion criteria could apply
fluoride varnish randomized clinical trial

Conditions: Dental Caries

Summary: the purpose of this study is to compare the efficacy of fluoride varnish (fv) applied once or twice a year with counseling to counseling alone in preventing early childhood caries (ecc) (tooth decay in children under the age of five).

this project was a prospective, randomized clinical trial (rct) among initially caries-free children from about six months old (when primary teeth erupt) up to age three at two public health facilities in san francisco, one serving a primarily latino and one a primarily asian population. the rct 1) compared the efficacy of once or twice/year fluoride varnish (fv) application and counseling to counseling alone in preventing early childhood caries (ecc); 2) assessed pre-intervention salivary markers (biologic and chemical), behavioral and demographic factors as predictors of ecc; 3) compared the efficacy of these interventions between sites serving different ethnic populations with a high prevalence of ecc; and 4) determined the salivary fluoride release profile following exposure to fluoride varnish.

Eligibility criteria:
inclusion * children \< 44 months old * caries-free * 4 erupted maxillary incisors * residing in fluoridated community (san francisco) exclusion * cleft palate * developmental or learning disabilities * children with transient residence (homeless, migrant, foster home) * children with an another household member participating in the study

Keywords: early childhood caries
comparison of oxygen saturation measurements using different glove colors in children

Conditions: Infection; Oxygen Saturation; Children

Summary: the aim of this study was to determine the effect of different colored gloves on oxygen saturation in pediatric patients whose oxygen saturation was measured by pulse oximetry in pediatric emergency department. the population of the study, which is planned as a prospective cohort study, will consist of children between the ages of 3-18 years who underwent oxygen saturation measurements in the pediatric emergency clinic of i̇zmir bakırçay university cigli and training and research hospital between october 2024 and october 2025.

the aim of this study was to determine the effect of different colored gloves on oxygen saturation in pediatric patients who underwent oxygen saturation measurement by pulse oximetry in pediatric emergency department. the population of the study, which is planned as a prospective cohort study, will consist of children aged 3-18 years who underwent oxygen saturation measurements in the pediatric emergency clinic of i̇zmir bakırçay university çiğli and training and research hospital between october 2024 and october 2025. the sample of the study will consist of children who meet the inclusion criteria on the specified dates and whose parents/legal guardians agree to participate in the study. descriptive characteristics form and oxygen saturation measurement value record form will be used for data collection.

Eligibility criteria:
inclusion criteria: * children between the ages of 3-18, * the parent/legal guardian or the child himself/herself agrees to participate in the study, * arterial blood gas measurement was performed, exclusion criteria: * the finger has a skin condition, * having nail polish on your fingernails, * having a severed finger,
efficacy of the transversus abdominus plane (tap) block for post-cesarean delivery analgesia

Conditions: Pain

Summary: the purpose of this study is to determine if patients having the transversus abdominal place (tap) block at the end of a cesarean delivery have less pain in the post-delivery period than those who do not. freezing medication is injected between the layers of muscle on either side of the belly, to freeze the nerves that carry pain stimuli from an abdominal wound. this technique has been useful for many abdominal operations, and has recently been studied in cesarean sections, however more information is needed.

a cesarean section is a surgical procedure and, like all surgeries, there is pain after the operation. the purpose of this study is to find out if patients have less pain after a cesarean delivery when they receive an injection of local anesthetic on either side of their abdomen, into the plane of the transversus abdominis muscle. we are also interested in whether or not this injection decreases the need for other pain-killing medication during this time. patients will randomly be assigned to receive either local anesthetic or a placebo. in addition, all patients will receive the usual standard of care and medication for pain. at 6, 12, 24 and 48 hours after the operation, patients will be asked about their pain and satisfaction with pain management. the risk of side effects is very low, as the block is done in an area with low blood supply. we propose that the addition of the tap block to the current multi-modal regimen of post-cesarean pain management will reduce pain scores and requests for additional analgesia post-operatively, as well as increase patient satisfaction with their pain control.

Eligibility criteria:
inclusion criteria: * women undergoing elective cesarean delivery exclusion criteria: * patients unable to communicate in english * patients with an american society of anesthesiologists (asa) classification of 3 or higher * patients with contraindications to spinal anesthesia * patients with an allergy to ropivacaine, morphine, ketorolac or acetaminophen * patients who have taken any pain medication in the past 24 hours * patients with a bmi \> 40

Keywords: cesarean section
investigation of the analgesic effects of intradermal and subdermal sterile water injection on active labor pain

Conditions: Labor Pain and to Reduce Pain

Summary: labour pain has different locations, intensity, quality and meaning for each woman, and the experience of pain changes throughout the delivery process. this pain is often associated with varying degrees of fetal malposition, particularly occipito-posterior position, which may apply pressure on pain-sensitive structures within the pelvis. administration of injections into the sacral area (both posterior iliac spines and 2 cm downward and medial) is used and have been shown to relieve the pain of labor. controlling pain with simple methods can reduce the desire of mothers to give birth by cesarean section and make them more diligent for normal birth. the benefit we expect from the research; since sterile water injection is a safe, effective and low-cost method, it is important to understand the effectiveness of its use to reduce labor pain. it also aims to increase the knowledge of gynecologists about this method.


Eligibility criteria:
inclusion criteria: * singleton pregnant women with cephalic presentation who are admitted to the delivery room clinic for delivery, who do not have an additional chronic disease, who have not given birth before, and who are in the second stage of labor (active cervical dilatation of 6 cm and above) will be included in the study. exclusion criteria: * patients who do not volunteer to participate in the study will be excluded.

Keywords: delivery pain analgesia