Kornimate/medical-research-clean huggingface dataset:
zhejiang nutrition and health study

Conditions: Metabolic Disease; Cardiovascular Diseases; Healthy Aging

Summary: this project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in zhejiang province. the cohort will include individuals in a wide range of age groups. the demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. it will give a deeper insight to the relation between nutrition and healthy aging and longevity. ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.

this project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in zhejiang province. the cohort will comprise individuals in a wide range of age groups starting at 6 years old. the participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. it will give a deeper insight to the relation between nutrition and healthy aging and longevity. ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.

Eligibility criteria:
inclusion criteria: * chinese citizens who have resided in the surveyed area for at least 6 months before the survey within the last 12 months. * aged 6 years or older. * they are included as resident households, which are comprised of people living together in one place based on family relationships, and at least one resident with permanent household registration. exclusion criteria: * residents living in functional zones such as construction worker dormitories, military barracks, schools, nursing homes, etc.

Keywords: nutrition health healthy lifespan
assessment of ability of 3d fluorscopy in aiding accurate syndesmotic reduction following traumatic ankle injury

Conditions: Displaced Ankle Fractures

Summary: the purpose of this study is to determine if use of new imaging technology termed "3d fluoroscopy" will lead the surgeon to change the position of the fractured bones to a more accurate position.


Eligibility criteria:
inclusion criteria: * skeletally mature * patients with unilateral, acute, displaced ankle fractures with preoperative evidence of syndesmotic disruption or intraoperative evidence of syndesmotic instability following malleolar fixation. exclusion criteria: * patients skeletally immature; * patients less than age 18 years and more than age 75; * patients with previous ankle trauma to either ankle; * patients with bilateral ankle injuries; * patients with previous osseous injuries to the tibia or fibula; and * patients with isolated syndesmotic injury and no fracture (i.e. high ankle sprains)

Keywords: 3d fluoroscopy
effect of swedish hand massage on pain in patients undergoing cabg surgery

Conditions: Coronary Artery Bypass Graft Surgery (CABG); Pain; Pain Management; Nursing; Massage; Hand Massage

Summary: coronary artery bypass grafting (cabg) surgery is performed commonly today. heart surgery performed on more than two million individuals every year leads patients experience severe postoperative pain for causes such as cutting of intercostal nerves along the incision line, pleural irritation caused by thoracic catheters etc. hand massage, which is one of the non-pharmacological methods, is an effective procedure that can be applied independently by nurses for pain management. the objective of this randomized controlled study is to investigate the effect of hand massage applied to the patients with cabg surgery during the postoperative intensive care process, on pain.


Eligibility criteria:
inclusion criteria: * patients who underwent cabg surgery, * stated that they were in pain, * 18 years old and older, * had not completed 48 hours after the surgical procedure, * accepted to participate in the study verbally and in writing after being informed about the study, * could understand the information given, * could read, write and speak turkish, * did not have any physiological, psychological or mental problems that would prevent verbal communication, * did not have any limb, vascular problem, wound or catheter that would prevent the application of hand massage, * were asa classified as i and ii, * had no previous hand massage experience, * did not participate in any other clinical studies during the same period, * did not develop any complications during and after the surgical procedure, * physiological parameters were within normal limits during the surgical procedure, * received the same type of treatment in the post-surgical period, * body mass index was within normal limits exclusion criteria: * patients who have complications during or after surgical intervention, * intubated, * have any limb, vascular problem, wound or catheter that prevents hand massage, * under the effect of pharmacological or non-pharmacological interventions that will affect pain, * obese (body mass index (bmi≥30),

Keywords: coronary artery bypass graft hand massage swedish massage pain nursing
karolinska interventional study of mammograhic density (karisma-1)

Conditions: Breast Cancer; Mammographic Density

Summary: a feasibility study, randomising to either 10 or 20 mg of tamoxifen. the primary aim is to identify the time to mammographic density change and piloting the procedures. it is known that a density change is seen after 12 months of 20 mg of tamoxifen, but the clinical experience indicates that an effect of drugs influencing mammographic density could be seen already after a few months. the second aim is to evaluate if there is a density change from 10 mg of tamoxifen equivalent to 20 mg.

the investigators want to conduct a feasibility study including 42 women who will be randomised to either 10 or 20 mg of daily oral tamoxifen. the primary aim of the study is to identify the time to mammographic density change and piloting the procedures. it is known that a density change is seen after 12 months of 20 mg of daily tamoxifen, but the clinical experience indicates that an effect of drugs influencing mammographic density could be seen already after a few months. the second aim of the pilot study is to see if there is a density change from 10 mg of tamoxifen equivalent to 20 mg and if there is a difference in adverse reactions between the two doses. interim analysis will be performed at 6 months, monitoring both safety and level of mammographic density change.

Eligibility criteria:
inclusion criteria: * previously participated in the karma study * attending the national mammography screening program, i.e. aged 40-74 * a mammogram, including a stored raw image, must have been taken within 3 weeks of baseline and start of therapy * having a mammographic volumetric density above the lowest 1/6, measured by volpara * informed consent must be signed before any study specific assessments have been performed exclusion criteria: * being pregnant or planning to become pregnant during the study * any previous or current diagnosis of breast cancer (including carcinoma in situ) * recalled (mammographic code 3 or above) after baseline screening mammography * any previous diagnosis of cancer, with the exception of non-melanoma skin cancer and in situ cancer of the cervix * currently using oestrogen and progesterone-based hormone replacement therapy * current use of hormone contraceptive with hormones, e.g. hormonal contraceptive pills, or progesterone implants. hormonal intrauterine devices are accepted. * a history of thromboembolic disease such as embolism, deep vein thrombosis, stroke, tia or cardiac arrest. * a history of immobilization, e.g. using wheelchair * uncontrolled diabetes defined as known untreated diabetes * hypertension at baseline, defined as systolic pressure higher than 140 mm hg and diastolic higher than 90 mm hg * use of drugs that interfere with cyp2d6 expression such as paroxetine, fluoxetine and bupropion

Keywords: tamoxifen low-dose randomized clinical trial
assessment of pain and quality of life in breast and prostate cancer patients with bone metastases

Conditions: Neoplasm Metastasis

Summary: this study will evaluate the safety, tolerability and efficacy of zoledronic acid administered intravenously every 3-4 weeks in patients with bone metastases from either breast cancer or prostate cancer.


Eligibility criteria:
inclusion criteria: * ambulatory patients \>18 years * proof of breast cancer or prostate cancer * diagnosis of at least one cancer-related bone lesion that is detectable on conventional radiographs or bone scan at screening * negative pregnancy test * ecog performance status of 0,1 or 2 exclusion criteria: * patients with abnormal renal function * patients with clinically symptomatic brain metastases * known hypersensitivity on zoledronic acid or other bisphosphonates * pregnancy or lactation other protocol-defined inclusion/exclusion criteria may apply.

Keywords: metastasis neoplasm pain breast cancer prostate cancer bone metastasis
faecal microbiota transplantation in obesity

Conditions: Obesity, Morbid

Summary: 40 patients meeting the criteria for obesity surgery are enrolled. fecal microbiota transplantation (fmt) will be administered in gastroscopy 6 months before obesity surgery. 20 of the patients will receive a fecal transplant of a thin donor and 20 will receive placebo - a transplant made of their on feces. changes in weight, laboratory values, general well being and stool microbiota will be measured up to one year after the surgery; one and a half years after fmt. the hypothesis is that fmt and the change in gut microbiota will help to reduce and maintain lower weight.


Eligibility criteria:
inclusion criteria: • candidates for the bariatric surgery bmi ≥ 40 or bmi ≥35 and at least two obesity-related co-morbidities such as type ii diabetes (t2dm), hypertension, sleep apnea and other respiratory disorders, non-alcoholic fatty liver disease, osteoarthritis, lipid abnormalities, gastrointestinal disorders, or heart disease. * availability of consecutive fecal samples during one year * compliance to attend gastroscopy and fmt * 18-65 years exclusion criteria: * unable to provide informed consent * pregnancy * type i diabetes mellitus * severe renal insufficiency, gfr\<30% * chronic or recurrent bacterial infection needing antimicrobial treatment * large hiatal hernia
mobile mri for immediate radiological acute cerebral lesion evaluation in stroke

Conditions: Stroke, Acute

Summary: this prospective observational study will evaluate the potential value of mobile mri in patients with suspected or proven acute stroke and transient ischemic attack (tia), undertaking additional imaging in the emergency department, acute stroke unit, or outpatient settings, and comparing diagnostic accuracy, diffusion-weighted imaging (dwi) lesion volume and detection of complications (brain swelling or haemorrhagic transformation). information on ease of use, tolerability and image quality will also be gathered.

the study will investigate mobile mri for immediate radiological acute cerebral lesion evaluation in stroke. the objectives are: 1. among patients with possible acute minor stroke or tia, to compare the detection rate of acute dwi lesions on mobile mri scan with routine imaging, describe number and distribution of lesions, and describe the intervals between mobile mri and routine diagnostic scan, and time to final clinical diagnosis 2. among patients with acute stroke of uncertain onset time, to compare the presence of dwi-fluid attenuated inversion recovery (flair) mismatch pattern on mobile mri with ct perfusion (ctp) mismatch. 3. among patients with confirmed acute ischaemic stroke, to compare the volume of dwi lesion on mobile mri with the core volume on ctp 4. among patients with established stroke post-thrombolysis or thrombectomy, to compare the incidence of brain swelling and haemorrhagic transformation on mobile mri with routine imaging 5. in all groups, to evaluate the tolerability and ease of use of the mobile mri scanner, and to rate image quality

Eligibility criteria:
inclusion criteria: * male or non-pregnant female \> or = 18 years of age * clinically suspected stroke or transient ischaemic attack, or confirmed clinical diagnosis of stroke or tia * consent of patient or legal representative exclusion criteria: * contraindications to mri brain scan as per standard mri checklist for nhs greater glasgow \& clyde
celladhesionmolecule endometriosisratio - camera

Conditions: Endometriosis (Diagnosis); Identification of Biomarkers in Serum

Summary: background: endometriosis, which is characterized by the growth of endometrial stroma and glands outside of the uterine cavity, is estimated to occur in 6-10% of women of reproductive age. clinical presentation of endometriosis can vary widely, often significantly reducing quality of life, and the mean interval between the onset of symptoms and obtaining a definitive diagnosis is approximately 10 years. currently, laparoscopy is the gold standard for diagnosing endometriosis; however, this procedure is invasive, carries surgery-related risks, and contributes to diagnostic delay. therefore, the field has an urgent need for an efficient, sensitive, non-invasive tool for diagnosing endometriosis. recently, it was shown that svcam-1/sicam-1 ratio is a promising serum biomarker, which may lead to the development of a new, efficient, sensitive, non-invasive tool for diagnosing endometriosis, thereby potentially avoiding surgical interventions. primary aim: to determine whether the serum svcam-1/sicam-1 ratio can be used todiagnose endometriosis. study design: prospective multicenter validation study


Eligibility criteria:
inclusion criteria: * unfulfilled desire for children * chronic pelvic pain * suspicion of endometriosis * cysts * myomas exclusion criteria: * acute infections * malign diseases * drug abuse * pregnancy * infectious diseases
a study of ly2922470 in healthy participants and participants with diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this trial is to evaluate the safety of the study drug in healthy participant and participant with diabetes. it will investigate how much of the study drug gets into the blood stream and how long it takes the body to get rid of it. information about any side effects that may occur will also be collected. the study consists of two parts. part a will study healthy participants in up to 4 dosing periods over approximately 6 weeks. part b will study participants with diabetes in up to 3 dosing periods over approximately 5 weeks.


Eligibility criteria:
inclusion criteria: for all participants: * must be a male, or a female who cannot become pregnant, and who is either a healthy participant, or who has type 2 diabetes * have a screening body mass index (bmi) of at least 18.0 kilograms per square meter (kg/m\^2) * have blood pressure, pulse rate, blood and urine laboratory test results acceptable for the study for participants with type 2 diabetes mellitus (t2dm): * do not have any change to their diabetes treatment (exercise with or without metformin) for at least 4 weeks prior to screening. * have a glycated hemoglobin (hba1c) value of greater than or equal to 6% and less than or equal to 11% at screening exclusion criteria: for all participants: * are currently participating in another clinical study or completed one in the last 30 days * are allergic to ly2922470 or other related drugs * have a history of significant heart, lung, liver, kidney, stomach or brain disease, or have any medical problems which may cause an increased risk during the study * have electrocardiogram (ecg) readings that are not suitable for the study * are infected with hepatitis b * are infected with human immunodeficiency virus (hiv) * have donated more than 450 milliliter (ml) of blood in the last 3 months or if have donated any blood in the last month * have a regular alcohol intake greater than 21 units/week (male), or 14 units/week (female), or are unwilling to stop alcohol as required by the study restrictions (1 unit = 360 ml of beer, or 150 ml of wine, or 45 ml of spirits) * smoke more than 10 cigarettes per day or are not willing to abstain from smoking while at the clinic. for participants with t2dm: * have had heart disease or stroke within 6 months before entering the study * have health complications due to poorly controlled diabetes as shown by blood and urine laboratory test results or based on physical examination and medical assessment as determined by the study doctor * have been hospitalized for poor control of diabetes (keto-acidotic episode) in the last 6 months * have used insulin to control diabetes in the last 1 year * show symptoms of high blood sugar, for example (e.g.), frequent urination, always feeling thirsty, or unexpected weight loss
a video-based hcv curriculum for drug users

Conditions: Hepatitis C; Opiate Dependence

Summary: the investigators hypothesize that a well-designed hepatitis c (hcv)video education curriculum for high-risk drug users will show measurable benefits in improving hcv testing, hepatitis a and b vaccinations, and hcv knowledge, attitudes, and motivations toward transmission behavior change. the investigators will use a 4-part modular video series designed for at-risk drug users, and in this 12 week study will assess its impact on testing/vaccinations as well as knowledge, attitudes, and motivations in methadone-maintained drug users as compared to a usual-care intervention.

injection drug users are at high risk for contracting hepatitis c (hcv). very few culturally-specific educational tools have been developed to improve outcomes in this population. we hypothesize that measurable improvements in hcv testing, hepatitis a and b vaccinations, and testable knowledge, attitudes, and motivations may be elicited by such a curriculum. in this study, we will investigate the impact of a 4-module short video educational series on these measures in in-treatment drug users maintained on methadone. subjects will be enrolled in 3 sequential cohorts of 150 each: usual care, a 4 weekly sequential video cohort, and a single-session intervention in which the 4 videos are viewed at once. subjects will undergo written testing for knowledge, attitudes about transmission behaviors, and motivations toward behavior change before the intervention, 4 weeks after the intervention, and 12 weeks after the intervention. additionally, we will measure and compare the rates of hcv testing and hav/hbv vaccinations before and at the 12-week time point in all cohorts.

Eligibility criteria:
inclusion criteria: * age 18 or older * enrolled on methadone maintenance within last 30 days exclusion criteria: * unable to provide informed consent * not interested in study * not able to speak or understand english

Keywords: hepatitis c heroin populations at risk testing vaccination
very severe malaria treated by intravenous artesunate

Conditions: Severe Malaria

Summary: in endemic areas, plasmodium falciparum malaria exacts a huge public health toll, causing close to half a million deaths each year. in non-endemic industrialized areas, imported malaria may develop. in france, around 5000 imported cases occured annually, including 10-15% of severe malaria. the criteria for defining severe malaria in endemic areas are established by the world health organization (who), and have been adjusted for severe imported malaria. in france, in order to optimize management, severe imported malaria is separated into two groups: very severe malaria (vsm) and less severe malaria (lsm). briefly vsm included coma and/or shock and/or respiratory failure and/or acidosis and/or hyperlactatemia and/or death during hospitalization. in france, severe imported malaria is treated with intravenous artesunate. little is known about the management of imported vsm in the icu with intravenous artesunate. in a french national multicentric retrospective frame, the main objective of the present study is to describe in detail: epidemiology, management, outcome and prognostic of very severe imported malaria treated with intravenous artesunate during the period 2011-2019. the second objective is to retrospectively compare two groups : vsm treated with intravenous artesunate in the icu during 2011-2019 versus vsm treated with intravenous quinine in the icu during 2000-2010.

see brief summary

Eligibility criteria:
inclusion criteria: * more than 18 year-old at the time of inclusion and * hospitalization in the icu and * for severe imported malaria (plasmodium falciparum) and * very severe malaria episode defined during the 72 first hours as : * neurological failure: glasgow coma scale score\<11 or repeated convulsions and/or * shock: systolic blood pressure\<80 mmhg despite adequate fluid loading or need for vasoactive drugs and/or * respiratory distress: mechanical ventilation or non invasive ventilation ; or if spontaneous breathing: arterial po2\ 32/min and/or * acidosis: plasma bicarbonate \<15 mmol/l, or ph\<7,35 and/or * hyperlactatemia \> 5 mmol/l and/or * death during hospitalization for vsm exclusion criteria: * less than 18 year-old at the time of inclusion or * opposition to participate in the present study

Keywords: severe malaria artesunate critical care quinine