Kornimate/medical-research-clean huggingface dataset:
evaluation of clinical and antibody response to covid-19 vaccination strategy in tbri, egypt

Conditions: Covid19

Summary: evaluation of the efficacy of the astrazenicacovid 19 vaccine to develop igg antibody and its level based on th12 weeks program. also to follow the changes of markers of coagulation (d-dimer) after vaccination compared to the basic level. a cardiology consultant will follow d-dimer results to be managed properly if there is a need. as it is expected to receive sinopharm vaccine there will be comparison between results of the two types of vaccine. to our knowledge this will be the first study done on egyptian population.

sars-cov-2 has been in the human population for more than a year now, causing severe disease in some and resulting in a pandemic that continues to put severe strain on economies and healthcare infrastructures worldwide. vaccination is considered as one of the greatest successes in medical history. based on prior experience with the development of sars-cov vaccines, all covid-19 vaccines must be subjected to the tests for protective effects and harmful risks derived from antibody-dependent enhancement that may contribute to augmented infectivity and/or eosinophilic infiltration. the sars-cov-2 vaccine is now being developed urgently in several different ways. in the uk, the first three vaccines have emergency use authorization, and a national rollout is in progress. many other countries are also instigating large scale vaccination programmes. assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus (sars-cov-2) in different populations is essential . the uk government recently decided to extend the interval between the first dose of the pfizer biontech and astrazeneca covid-19 vaccines from 3 weeks to 12 weeks to maximise the number of people receiving the initial dose, despite the trials only providing vaccine efficacy data based on a schedule of 21 days between doses. many reports were raised claiming astrazenica vaccine for the development of vascular thrombosis and studies are not finalized regarding this issue . china is regarded as one of the world's leading countries in sars-cov-2 vaccine development, up to date the last inactivated vaccine international clinical (phase iii) trial was launched in the united arab emirates by sinopharm china national biotec group (cnbg).the ability to track and trace vaccines through the vaccine supply chain down to persons vaccinated has to be enhanced.

Eligibility criteria:
inclusion criteria: * all male and female above 18 years exclusion criteria: * age below 18 years -pregnancy- * fever * igm positive for covid 19
evaluating the use of large-dose, extended interval vancomycin intravenous administration for skin and soft tissue infections

Conditions: Skin and Soft Tissue Infections

Summary: our hypothesis is that large-dose, extended-interval vancomycin (30 mg/kg iv q24h) administration provides non-inferior clinical efficacy and microbiological efficacy to standard vancomycin (15 mg/kg iv q12h) administration for skin and soft tissue infections in an outpatient setting.


Eligibility criteria:
inclusion criteria: * age 19 to 70 years * weight 40 - 80 kg * suspected or confirmed skin or soft tissue infection for which vancomycin is indicated * subject referred to or admitted into opat by an infectious disease specialist or emergency physician * subject able to provide informed consent exclusion criteria: * known history of allergy to vancomycin * pregnancy * granulocytopenia (\< 1x109/l) * renal impairment (serum creatinine \> 177 µmol/l or egfr \< 50 ml/min) * known history of vestibular disease or hearing loss * subjects treated with vancomycin within the previous month * subjects who have received more than 24 hours of vancomycin * subjects receiving other antimicrobials that cover mrsa (e.g. cotrimoxazole, rifampin, linezolid)

Keywords: outpatient skin and soft tissue infections vancomycin intravenous
symptom control and impact on daily life in patients with gastroesophageal reflux disease

Conditions: Gastroesophageal Reflux Disease

Summary: the purpose of this study is to evaluate the impact of gastroesophageal reflux disease (gerd) treatment in primary care setting on symptom control and daily life in symptomatic gerd patients, using both gerd questionnaire and clinical symptoms assessment

a prospective, observational study to describe symptom control and impact on daily life in patients with gastroesophageal reflux disease (gerd)

Eligibility criteria:
inclusion criteria: * patients known or newly diagnosed with gerd * patients with typical gerd symptoms as heartburn and regurgitation for ≥2 days in the previous week * patients, currently not treated with a proton pump inhibitor exclusion criteria: * patients who have been receiving treatment with non-steroidal antiinflammatory drugs within two weeks prior the inclusion in the study * patients with medical history of surgery of the esophagus, stomach or duodenum * pregnant or nursing females

Keywords: gastroesophageal reflux disease gerd questionnaire primary care setting
evaluation of dapagliflozin taken twice-daily

Conditions: Type 2 Diabetes

Summary: this study is being carried out to see if dapagliflozin - administered in a daily dose of 2.5 mg given twice a day or 5 mg twice a day or 10mg once daily - in addition to metformin, is beneficial in diabetes treatment, and if so, how it compares to treatment with metformin alone.


Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures * diagnosis of t2dm * current antihyperglycaemic treatment with metformin immediate release formulation monotherapy \>/= 1500 mg/day at a stable dose for at least 10 weeks prior to enrolment. other treatment with oads within the 10 weeks prior to enrolment is not permitted. * hba1c ≥ 6.7% and ≤10.5%, based on central laboratory values from screening visit, and enrolment visit 1. exclusion criteria: * diagnosis of type 1 diabetes mellitus, known diagnosis of maturity onset diabetes of the young (mody) or secondary causes of diabetes mellitus * history of diabetic ketoacidosis * symptoms of poorly controlled diabetes including, but not limited to, marked polyuria, polydipsia, and/or greater than 10% weight loss during the 3 months prior to enrolment * fpg \>270 mg/dl (\>15.0 mmol/l) * bmi \>45 kg/m2

Keywords: type 2 diabetes metformin treated inadequate control metformin treatment alone
selective cox-ii inhibitor as an adjuvant therapy in patients with resectable advanced stomach cancer ( histological staging ≥ t2n1) - a multi-centre prospective randomised controlled trial

Conditions: Cancer of Stomach

Summary: the purpose of this study is to investigate the efficacy of selective cox-ii inhibitor in patients with curative resection performed for locally advanced stomach cancer.

cyclo-oxygenase (cox) is a family of enzymes regulating the conversion of arachidonic acid to prostaglandins. cox-ii is an inducible enzyme, which may be upregulated when there are stimuli such as inflammation or hypergastrinaemia. despite radical surgery, patients with stomach cancer of advanced stages often have a poor prognosis. reported survival in those with diseases of stage iiia or above is less than 40%. methods to improve patients outcome have been explored for decades with little success. in the light of current understanding on the relation between cox-ii and stomach cancer, selective cox-ii inhibitor may be used as a novel adjuvant therapy after gastrectomy to prevent recurrence of gastric carcinoma. the advantages of cox-ii inhibitors are being relatively non-toxic with minimal side effect.

Eligibility criteria:
inclusion criteria: * resectable advanced stomach cancer (tumour stage ≥ t2n1 according to the 5th edition of uicc staging system) without peritoneal or distant metastases. * normal renal function exclusion criteria: * solid organ metastases * poor performance status * already on long-term aspirin or nsaid * renal or hepatic dysfunction * bleeding disorder * hypersensitive to cox-ii inhibitors/aspirin/nsaid * no history of myocardial infarct or stoke
a registry study of 100 thousand cases of pediatric patients on reduning injection（a chinese medicine injection）used in hospitals in china

Conditions: Upper Respiratory Tract Infection; Acute Tracheobronchitis

Summary: this study was advocated by institute of basic research in clinical medicine, china academy of chinese medical sciences in february 2018. the purpose of this study is to make a monitoring of adverse reactions in 100 thousand children aged 14 years and below to see whether reduning injection is safe and the characteristic and mechanism of anaphylactic reaction used reduning injection in hospitals in china.

in order to observe the clinical characteristics and adverse reactions of patients aged 14 and below using reduning injection in hospital,registry study is suitable method in this area. otherwise, nested case control study is used to find out the mechanism of anaphylaxis. calculating the incidence of adverse drug reactions is one of the main aims for this study. 100000 cases need to be registered at least. the aim population is who using reduning injection from february 2018 to december 2018.

Eligibility criteria:
inclusion criteria: patients aged 14 and below using reduning injection from february 2018 to december 2018. exclusion criteria: none
implementing resistance exercise to reduce frailty for older adult

Conditions: Sarcopenia

Summary: to develop an intervention specifically targeted for these clients who have the frailty syndrome. the investigators propose to develop an exercise intervention that can reduce frailty in older adults to facilitate their ability to age-in-place. the long-term objective of this work is to develop a package of interventions that can be administered within the existing medicaid home and community based services (hcbs) waiver programs. the specific goal of this proposal is to develop a resistance exercise intervention to reduce frailty in older adults receiving long term care services in their home through the illinois community care program, a hcbs waiver program.


Eligibility criteria:
inclusion criteria for home care aides: - employees of help at home, with one eligible client inclusion criteria for clients: * aged 65+ years * receive hca services two or more days per week * english-speaking * not currently participating in regular exercise as defined as 30 minutes three or more days per week, - - no health problems that contraindicate participation in exercise based on the easy: exercise assessment and screening for you * telephone interview for cognitive status score \> 26 exclusion criteria for hcas: - no clients who enroll in the study exclusion criteria for clients: * legally blind, no voluntary extremity movement * physician does not provide clearance for participation * classified as non-frail based on the share-fi frailty testing * telephone cognitive status score \< 25.
seizures after cardiac surgery -- a study with continuous eeg monitoring

Conditions: Non-convulsive Seizures

Summary: the aim of this study is to determine the frequency of nonconvulsive seizures after cardiac surgery using an electroencephalogram or eeg, which records brainwaves through the scalp.

background: most patients do not have any neurological complications after cardiac surgery, but fewer than 1% may have a seizure (abnormal brain activity), with or without a convulsion. this can be due to a reaction to certain types of drugs or less commonly stroke or inflammation. some seizures in post-operative and intensive care unit patients do not result in convulsions, but rather the abnormal brain activity simply causes confusion or unresponsiveness. the incidence of this type of "nonconvulsive"seizure after cardiac surgery is unknown. purpose of the study: the aim of this study is to determine the frequency of nonconvulsive seizures after cardiac surgery using an electroencephalogram or eeg, which records brainwaves through the scalp. design of the study: the investigators target is to enroll 150 patients undergoing cardiac surgery. the investigators are including patients greater than 18 years of age who are admitted to the csru immediately after cardiac surgery. included patients are of normal mentation and are able to give their own consent. the investigators will exclude only those patients for whom technical issues prevent us from recording the eeg.

Eligibility criteria:
inclusion criteria: * all adult patients able to give informed consent and undergoing cardiac surgery exclusion criteria: * inability to record subhairline eeg data due to technical/mechanical reasons patients not giving informed consent

Keywords: non-convulsive seizures cardiac surgery postop 24 hour eeg monitoring
genetics of coronary artery disease in alaskan natives (gocadan)

Conditions: Heart Diseases; Cardiovascular Diseases; Atherosclerosis; Hypertension; Diabetes Mellitus; Coronary Arteriosclerosis

Summary: to document cardiovascular disease and cardiovascular disease risk factors among 1,200 native alaskans who are members of approximately 40 families.

background: there are many compelling reasons to study heart disease in the native alaskans. these eskimo villages are remote and isolated. the traditional lifestyle is being eroded by mechanization and a westernized diet. there has been relatively little outside genetic influence and they are, like the american indians of the lower 48 states, beginning to show a marked acceleration in the prevalence of atherosclerosis and coronary artery disease. design narrative: the study is a family-based, cross sectional study. recognized and emerging risk factors and prevalent cardiovascular disease are documented in each individual through a standardized interview, physical exam, laboratory measurements, carotid ultrasound, ecg, and a review of centralized medical records. assays will be made of contemporary samples and serum specimens stored at the anchorage center cdc antedating this study (10 to 20 years ago) for specific markers of inflammation and serologic responses. through a ten-centimorgan genetic map, attempts will be made to find specific genes that relate to cardiovascular disease. the study uses standard methods to assess risk factors relating to lipid metabolism, hypertension, and diabetes mellitus. importantly, the study also uses state-of-the-art methods for detection of infectious disease exposure, specifically to c. pneumoniae, cytomegalovirus, and other infectious agents hypothesized to play a role in atherogenesis. a case-control age-matched design is used to analyze the infectious disease burden.

Eligibility criteria:
no eligibility criteria
does cultivating self-compassion improve resilience to criticism and improve mental health in adults with adhd?

Conditions: ADHD; Depression; Stress; Self-Criticism; Anxiety; Wellbeing; Self-compassion

Summary: this study aims to investigate the effect that increasing levels of self-compassion may have on levels of perceived criticism, self-criticism, and mental health of adults with adhd. a secondary aim of the study is to capture how feasible using an online self-guided self-compassion practice maybe with people with adhd. research questions 1. does a short self-guided self-compassion intervention increase levels of state and/or trait self-compassion in adults with adhd over time? 2. are changes in state and/or trait self-compassion associated with changes in levels of self-criticism or perceived criticism? 3. are changes in state and/or trait self-compassion associated with improvements in mental health? 4. are changes in mental health mediated by changes in self-criticism or perceived criticism?


Eligibility criteria:
inclusion criteria: * self-report a formal diagnosis of adhd * scores on the adult adhd self report questionnaire (asrs) meet the clinical cut-off. * no previous engagement with self-compassion interventions/practice exclusion criteria: * no previous experiences of trauma. * no ptsd * no personality disorder

Keywords: self-compassion criticism adhd mental health
investigation of the relation between trigger digit and carpal tunnel syndrome

Conditions: The Comorbidity Between the Trigger Digit and Carpal Tunnel Syndrome

Summary: the purpose of this study is to comprehend the association between the trigger digit and carpal tunnel syndrome based on the quantification of the tendon and nerve characteristics. it includes three parts. the first part is an observational study. the aim of the first part is to attempts to measure the gliding and morphological characteristics of the flexor tendons and median nerve in the longitudinal or cross-sectional directions via the ultrasonographical images incorporating with the motion capture experiment of the wrist and fingers. the gliding and morphological features of the tendons and nerve will be compared under different postures or movement patterns of the wrist and hand. the second part is an interventional study. the aim of the first part is to establishes a novel hybrid rehabilitation protocol which combines the tendon gliding exercise with nerve mobilization to treat either the trigger digit or the carpal tunnel syndrome. a randomized controlled trial to investigate the short-term treatment effect and the follow-up examination will be carried out as well. the third part is an observational study. the aim of the first part is to investigate the effects of carpal tunnel release on the hand performances from functional perspectives. in addition, a novel wrist orthosis will be developed to eliminate the bowstringing effect of the flexor tendons after carpal tunnel release.


Eligibility criteria:
inclusion criteria: 1. healthy subjects without any history musculoskeletal diseases 2. patients with carpal tunnel release surgery exclusion criteria: * subjects with fracture or surgery in the upper extremity.
efficacy of sln block for chronic cough

Conditions: Cough; Superior Laryngeal Nerve Block; Neurogenic Cough

Summary: this is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value). eligibility for the study include the following: age \>18, cough history suggestive that the nerve to the voice box is overactive, non-smoker, patients will be followed over time and assigned to either the treatment or placebo group at random. the treatment would be four superior laryngeal nerve blocks and the placebo would be four saline injections (the inactive substance). study team will measure if the injection improved cough and ask patients to keep a log of symptoms and fill out questionnaires at each visit. after the four injections, patients will follow up in 3 months to see if cough has returned and if so, how severe the cough is.


Eligibility criteria:
inclusion criteria: * history consistent with neurogenic cough * exclusion of other etiologies (see exclusion criteria) * age ≥ 18 exclusion criteria: * current neuromodulating medication use * untreated other etiologies of cough: current smoker current ace/arb use abnormal pfts within 6 months uncontrolled osa abnormal cxr within 6 months rsi \> 13 or rfs \>11 and workup positive for gerd (esophagram, 24-hour ph probe, manometry, egd)

Keywords: superior laryngeal nerve block chronic cough
evaluation of the accuracy and reliability of the percentage of glottic opening score

Conditions: Intubation

Summary: current classifications of the laryngeal view during laryngoscopy are criticized for being subjective. the modified cl classification is criticized as it does not predict difficult intubation and especially grade 2 is operator dependent and partial view is not well defined. the numerical expression of the percentage of the glottic aperture (pogo = percentile of glottic opening) is another score. in this score, a pogo score of 100% accounts for full visualization of the larynx starting from anterior commissure to the posterior cartilage, while 0% indicated a complete absence of glottic opening. previous validation studies reported on the reliability of pogo; however, accuracy was not evaluated. the use of a standard and effective classification method will facilitate and accelerate communication between anesthetists in difficult life-threatening situations such as difficult airway / difficult intubation / difficult ventilation and contribute to patient safety. the use of common terminology can also facilitate the evaluation of the performance of intubation tools. the aim of this study was to evaluate the accuracy and intra and inter rater reliability of the pogo score

reviewer anesthesiologist will be asked to score still images of laryngeal views, which will be obtained from patients requiring intubation for general anesthesia, after obtaining written informed consent. the images of the larynx will be captured first with the macintosh blade and thereafter with the d blade. an expert panel will score these images with the cormack lehane and pogo scores. the set of images will be prepared from patients with both difficult and normal airway anatomy. some images in the series will be repeated to assess intra rater variability. the anesthesiologist will be asked to rate 20 images both with the cl and pogo scores. the experience of the raters in airway management, their experience with videolaryngoscopy and scoring systems used currently when documenting videolaryngoscopy and demographic data will be also obtained. the pogo scores of the participants and investigators will be compared. the primary outcome measure was the reviewer's agreement with the correct pogo scores (accuracy).

Eligibility criteria:
inclusion criteria: • patients receiving general anesthesia exclusion criteria: • emergency surgery-

Keywords: intubation laryngeal view scoring systems larynx