Kornimate/medical-research-clean huggingface dataset:
keratoconus and metalloproteinases investigation

Conditions: Keratoconus

Summary: corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of mmp at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the extracellular matrix metalloproteinase inducer (emmprin) and galectin-3 by epithelial cells. a differential expression of emmprin, galectin-3 and metalloproteinases (mmp) may be observed between the apex of the keratoconus and the peripheral cornea. highlighting the implication of emmprin and galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.


Eligibility criteria:
inclusion criteria: * age \> 18 years old * patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods) * patient with keratoconus undergoing his first corneal graft for optical indication (control) exclusion criteria: * patient with keratoconus undergoing corneal graft for tectonic indication * patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control) * pregnant or breast feeding patient * patient under judiciary protection * patient opposition to participate in the study
combination therapy in amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: the purpose of the study is to determine the safety and the efficacy of tretinoin and pioglitazone hcl in patients with als who are currently on riluzole.

physicians at phoenix neurological associates (pna) are looking for individuals diagnosed with als to participate in a double-blind, placebo controlled study of tretinoin and pioglitazone hcl, used in combination with riluzole, for treating als. this investigator initiated trial conducted by dr. todd levine and dr. david saperstein will help determine whether tretinoin and pioglitazone hcl, in combination, can slow the progression of als. at present, there is little to no effective therapy for als, nor is there a known cause. therefore there is a tremendous unmet need for more effective therapy for this disease and that is why the physicians at pna have been very interested in the role of developing a more active anti-excitotoxic cocktail for patients with als. since recent data have suggested that inflammatory mechanisms may interact with and promote neurodegeneration (where cells in the spinal cord and brain are lost), there have been a number of anti-inflammatory treatment strategies that have been evaluated in animal models. some studies have shown that mice that were given pioglitazone hcl demonstrated improved muscle strength and body weight, exhibited a delayed disease onset as well as had a longer survival rate compared to non treated mice. in addition to these studies, retinoic acids have been studied extensively in various models of the injured nervous system. these studies have shown that retinoic acids, such as tretinoin may be neuroprotective and support axonal growth, which could in turn slow disease progression. the purpose of this study is to determine if such a drug "cocktail" could offer the best chance of attaining a significant reduction in disease progression by utilizing currently available fda-approved agents

Eligibility criteria:
inclusion criteria: * el escorial classification of laboratory supported probable, probable, or definite als * age 18 - 85 years * male or female * fvc greater than or equal to 70% predicted exclusion criteria: * patients with fvc below 1.5 l or below 70% predicted * history of liver disease * severe renal failure (crcl\<30) * history of coronary artery disease requiring placement of stents, bypass surgery or previous myocardial infarction * ekg at baseline with evidence for previous myocardial infarction, cardiomyopathy, or arrhythmia * history of intolerance to riluzole, tretinoin, or pioglitazone hcl * history of diabetes * any other comorbid condition which would make completion of trial unlikely

Keywords: als treatment tretinoin pioglitazone hcl actos tau levels als
tension-type headache gene expression and methylation

Conditions: Tension-Type Headache, Unspecified, Intractable

Summary: tension-type headache (tth) refers to pain radiating from the forehead to the back of the head as a bilateral band. it often occurs without warning and spreads to the neck muscles. patients describe it as tension, pressure, or dull pain. it is usually triggered by stress. the complexity of the processes is the biggest difficulty in diagnosing and treating tth. although there are genetic connections, there are no single responsible genes.

130 tth patients and 117 healthy controls were included in the study. serum markers of the patients were measured. wnt5a, responsible for the wnt-b catenin signaling pathway, and its receptor fzd3 were examined in the pathogenesis of tth. expression changes and methylation profiles of genes were obtained. genetic and serum parameters were compared. diagnostic powers were determined by roc analyses.

Eligibility criteria:
inclusion criteria: * (ichd)-3 criteria * male and female * 17-82 years * not diagnosed with tension-type or other primary headaches exclusion criteria: * tension-type headache not diagnosed * below 16 ages * pregnant woman * subdural hematoma * intracranial mass

Keywords: tension-type headache gene expression gene methylation
autostereoscopic dynamic near vision testing

Conditions: Visual Suppression; Amblyopia; Color Vision Defects

Summary: this is an analysis of tests of near vision. visual perception testing using a novel program on an interactive three dimensional electronic device: autostereoscopic dynamic near games for monocular visual acuity, stereopsis and color are compared with other conventional or similar tests.

subjects with normal vision, exceptional vision, or visual deficits have near vision tested on the pdi check game and compared to other clinical tests. interclass correlation and bland altman analysis utilized for continuous data. sensitivity and specificity calculated for defined clinical entities. subjects are not assigned to either one screening test or another; instead different tests are compared.

Eligibility criteria:
inclusion criteria: * normal subjects, patients with deficient binocular vision, patients with color vision disorders exclusion criteria: * phthisis, enucleations

Keywords: stereopsis, visual acuity
efficacy of diterpene ginkgolides meglumine injection in elderly patients with ischemic stroke

Conditions: Stroke; Ischemic Stroke; Nervous System Diseases; Cerebral Infarction; Brain Ischemia; Brain Infarction

Summary: a randomized positived-controlled study of diterpene ginkgolides meglumine injection (dgmi) vs ginaton in patients with ischemic stroke (is) was conducted between7/2013 and 4/2014. the study was designed to test efficacy of dgmi for is. post hoc analysis of this trial was conducted to evaluate the efficacy of dgmi in elderly (aged≥65 years) is patients.

to examine the efficacy of diterpene ginkgolides meglumine injection (dgmi) vs ginaton in patients with ischemic stroke (is) by age subgroups. the efficacy analysis was a post hoc analysis of data from a large randomized, controlled study was performed in a cohort of 998 is patients. patients were pooled and grouped by age (elderly aged ≥ 65 years and non-elderly aged \< 65 years).proportion of patients with modified rankin scale (mrs) less than or equal to 1 at 90days is the primary outcome measure.

Eligibility criteria:
inclusion criteria: * 35 years of age or older, and gender not limited; * between 2 and 4 weeks onset of ischemic stroke; * the first onset, or always not obvious legacy of stroke sequela (mrs acuities were before the onset of 1); * understand and voluntarily signed informed consent. exclusion criteria: * known severe liver or kidney dysfunction; * known allergies for ingredients in the investigational product; * known medical condition likely to limit survival to less than 3 months; * known dementia, mental impairment, or unsuitability for participation as judged by the investigators; * hemorrhage transformation after infarction, or bleeding tendency; * pregnancy or breastfeeding; * known lower extremity venous thrombosis; * having participated in others clinical trial within 1 month before randomization.

Keywords: diterpene ginkgolides meglumine injection acute ischemic stroke effectiveness
validity of a home respiratory polygraphy for the diagnosis of obstructive sleep apnea in children (dinisas)

Conditions: Obstructive Sleep Apnea

Summary: to assess the diagnostic validity and cost-effectiveness of a home respiratory polygraphy (hrp) performed at home compared with the standard polysomnography (psg) in children with clinically suspected obstructive sleep apnea (osa).

aims: to assess the diagnostic validity and cost-effectiveness of a home respiratory polygraphy (hrp) performed at home compared with the standard polysomnography (psg) in children with clinically suspected obstructive sleep apnea (osa). methodology: design: randomized, prospective, multicenter, double blind and crossover trial. the study will include 320 children, both sexes, with clinical suspicion of obstructive sleep apnea (osa). measurements: to all patients with clinical suspected osa and referred to the sleep units, the following questionnaires and measurements will be performed: a) clinic history; b) anthropometric variables: weight, height, body mass index, neck circumference and percentile; c) chervin questionnaire, quality of life and clinical questionnaires and comorbidity; d) psg in the sleep laboratory; e) hrp at home; f) quantitative unbiased proteinic urine analysis and g) cost-effectiveness variables. analysis: data from hrp and from full psg will be compared as follows: 1) agreement of results according to the different apnea-hypopnea index by using the roc curves; 2) the concordance of the diagnosis and treatment decisions when using clinical findings and data from psg or hrp at home, 3) all data will be analyzed independently by participating hospitals according the cohen kappa method, 4) a diagnosis paradigm based on proteinic defined variables and 5) a cost-effectiveness analysis of the different diagnostic and therapeutic procedures will be performed.

Eligibility criteria:
inclusion criteria: * children between 2 and 14 years of age of both sexes consecutively assessed for clinical suspicion of osa, defined as: snoring children with observed respiratory and / or apnea pauses and / or ventilatory effort during observed sleep, and who were asked for a sleep test * written informed consent signed. exclusion criteria: * place of residence more than 100 km from the hospital * psychophysical incapacity to perform the study at home * severe, unstable or exacerbated cardio-vascular, cerebro-vascular or respiratory disease, that makes it impossible to carry out adequate studies * children with chronic insomnia and / or depressive syndrome * children with malformative syndromes, down syndrome and neuromuscular diseases * complete or near complete nasal obstruction that prevents obtaining a quality signal with the hrp * history of surgery and / or previous positive continuous pressure (cpap) for osa

Keywords: child obstructive sleep apnea home respiratory polygraphy diagnosis validity polysomnography
a study of the impact of digital intervention on parents/primary caregivers' myopia prevention and control health literacy on preschoolers' myopia and physical and mental health

Conditions: Myopia; Mental Health; Obesity

Summary: the study is a randomized controlled trial based on digital interventions, involving pre-school children and their parents or major caregivers. to compare the myopia and physical and mental health status of preschool children before and after intervention between intervention group and control group, to confirm the effect of digital intervention on prevention and control of myopia and physical and mental health of preschool children.

in this study, wechat, online courses, live broadcast and sms were used to transfer the knowledge of myopia prevention and control to parents/primary caregivers, and to promote their attitude and behavior change. the intervention period was from october to december 2025. the control group did not 2024 any intervention. the prevention and control of myopia and health literacy of the parents and main adopters were collected at baseline and after the intervention respectively, visual data and physical and mental health status of preschool children were collected every six months.

Eligibility criteria:
inclusion criteria: * no cognitive impairment and communication impairment * volunteer and sign the informed consent * fill in the questionnaire * skilled in using electronic equipment exclusion criteria: * children with congenital glaucoma, cataract, strabismus and other congenital eye diseases * children with a history of ocular trauma, eye surgery, or complications of myopia * do not cooperate with the investigation
prevalence of pelvic floor dysfunctions in female badminton athletes and sedentary

Conditions: Pelvic Floor Disorders

Summary: the objective of the study is to know the prevalence of pelvic floor dysfunctions in female badminton athletes compared to sedentary women, and the hypothesis is that the prevalence of pelvic floor dysfunctions is going to be higher in female badminton athletes.

after being informed about the study, all participants giving written informed consent will complete the personal data questionnaire and the questionnaires validated to spanish population "international consultation on incontinence questionnaire-short form" (iciq-sf), "pelvic floor distress inventory short form" (pfdi-20), "female sexual function index" (fsfi) and the sf-12 questionnaire. after that, inclusion and exclusion criteria will be assessed, and participants will be allocated into cases and controls group. both groups will undergo the same procedures. firstly, the evaluation of stress urinary incontinence and pelvic organ prolapse signs will be performed by using the cough stress test and pelvic organ prolapse quantification system; and secondly, the evaluation of pelvic floor muscle strength by using manometry.

Eligibility criteria:
inclusion criteria: * cases: women who practice recreational badminton and/or are federated and compete. * controls: sedentary women and/or do not meet the recommendations of the world health organization (150-300 minutes of moderate-intensity aerobic physical activity or 75-150 minutes of vigorous-intensity aerobic physical activity). exclusion criteria: * connective tissue diseases (ehlers-danlos syndrome, marfan syndrome or hypermobility syndrome). * pregnant at the time of the study. * give birth in the last 12 months. * not understanding spanish language.

Keywords: prevalence pelvic floor disorders racquet sports sedentary behavior women
clinical trial comparing open and laparoscopic nissen fundoplication in children

Conditions: Gastroesophageal Reflux

Summary: the purpose of this study is to determine whether short- and long-term outcomes are different between open and laparoscopic nissen fundoplication performed in children younger than 2 years of age.

nissen fundoplication is a commonly performed procedure in infants and children with gastroesophageal reflux and a variety of other medical conditions including respiratory compromise, severe neurologic impairment, failure to thrive and swallowing dysfunction. randomized controlled trials in adults have shown that laparoscopic fundoplication is a safe procedure that results in lower morbidity, shorter hospital length of stay and similar 5-year recurrence rates when compared to an open procedure. the aim of this study is to compare laparoscopic and open nissen fundoplication in children less than 2 years of age. children younger than 2 years of age presenting for nissen fundoplication will be randomized to either a laparoscopic or an open procedure. patients who have already undergone anti-reflux surgery or whose hospitalization is anticipated to be prolonged by an unrelated illness will be excluded. all procedures will be performed at a single institution by two surgeons who will perform both the open and laparoscopic procedures. a total of 68 patients will be needed (34 in each group) to detect a 20% difference in length of stay at a significance level of p \< 0.05 and power of 80%. patients will be followed for up to 2 years postoperatively. variables to be compared between the two groups will include age, gender, presence of neurologic impairment, presence and specification of any congenital abnormalities, total operative time, total dose of narcotic analgesia required, postoperative day on which the patient tolerated full feedings, postoperative and total lengths of stay as well as the occurrence of postoperative complications (including wound infection and the need for immediate reoperation). the primary outcomes analyzed will be length of stay and amount of narcotic analgesia required. longer-term outcomes including persistent gerd, wrap failure and need for reoperation within 24 months of the initial procedure also will be determined.

Eligibility criteria:
inclusion criteria: * clinical or radiographic diagnosis of gastroesophageal reflux * age less than 2 years (24 months) at the time of surgery exclusion criteria: * prior fundoplication procedure * concomitant need for an intraabdominal procedure (except gastrostomy tube placement) * esophageal dysmotility * hospitalization expected to be prolonged due to a concurrent illness actively being treated (e.g. congenital heart disease requiring surgical repair during the same hospitalization)

Keywords: nissen fundoplication gastroesophageal reflux
platelet rich plasma and autologous fat graft for diabetic ulcer

Conditions: Diabetes Mellitus Foot Ulcer

Summary: conventional management of diabetic ulcers is associated with slow healing, high costs and repeated trips to clinic. stem cells contained in fat grafts can differentiate into pro-healing cells and release growth factors with evidence suggesting a benefit in wound healing. platelet-rich-plasma (prp), an autologous blood-product, demonstrates pro-healing properties through releasing pro-healing factors and regulating angiogenesis. when used combination there is evidence of additional wound healing benefits. the aim is to investigate the feasibility of conducting a randomised controlled trial with fat grafting and fat/prp co-grafting as interventions for diabetic ulcers. we aim to develop pilot data which can power a multi-centre study. the aim of the trial would be to determine the feasibility of the trial by assessing recruitment, randomisation and retention of participants. we would also evaluate the rate of wound healing in diabetic ulcers when treated with conventional dressings, fat grafting alone and fat+prp combination. the secondary aims will be to understand the mechanism of the healing process, the health related quality of life and patient satisfaction and the cost implications. the study is a single-blinded randomised controlled trial of approximately 30 patients with three parallel treatment arms. each patient will be followed up for 12 weeks and the rate and degree of wound healing will be assessed. wound biopsies will be taken at day 0, week 1 and week 4 and will undergo subsequent histological analysis to evaluate the mechanism of healing. the study is expected to last two years from recruitment of the first patient and will be conducted at royal free hospital and ucl division of surgery and interventional science. the combination of fat+prp may provide diabetic patients the option of a single treatment with improved healing, shorter followup and a reduced cost burden. validation of the mechanism of healing through histological analysis will confirm clinical findings and help guide future research.

rct to compare fat grafting and fat grafting with prp in chronic diabetic wounds.

Eligibility criteria:
inclusion criteria: * male or female; * age 18-90 at the time of consent; * diabetic foot ulcer (dfu) measuring more than 0.5cm x 0.5cm and less than 10cm x 10cm; * wound with clean, healthy granulating bed, with minimal adherent slough; * patient understands and is willing to participate and can comply with weekly visits and follow-up regime. exclusion criteria: * wound with active infection; * patients with underlying vascular insufficiency (abpi\<0.3); * uncontrolled diabetes mellitus, as measured by an hba1c \> 90mmol/mol; * presence of one or more medical conditions, including renal, hepatic, haematologic, active auto-immune or immune diseases that, would make the subject an inappropriate candidate for this ulcer healing study; * patient not fit for surgery (asa classification \> 4).

Keywords: diabetic foot ulcer diabetes mellitus fat grafting platelet rich plasma wound healing
donors with nephrolithiasis at the time of transplant evaluation (donate). long term follow-up.

Conditions: Kidney Stones

Summary: we believe that kidney donors with kidney stones accepted for a donation do not have an increased risk of loss of kidney function and will not be at increased risk of symptomatic kidney stone events compared to donors without a history of kidney stones.

indiana university health center has a large nephrology and transplant service which is well versed in taking care of kidney donors with history of kidney stones. we believe that kidney donors with kidney stones accepted for a donation do not have an increased risk of loss of kidney function and will not be at increased risk of symptomatic kidney stone events compared to donors without a history of kidney stones. in this study we are contacting past kidney donors and participants with kidney stone who were declined as kidney donors. we will use blood tests, 24-hour urine tests, computed tomography (ct) scan, patient reported medical history and medical history in the patient's chart to gather data. this data will help us compare non stone donors, stone donors, and participants with kidney stone who were declined as kidney donors.

Eligibility criteria:
inclusion criteria: * age \> 18, * evaluation for kidney donation \> 2 years ago, with a) no history of kidney stones, or kidney stones on imaging and successfully donated a kidney b) either had history of kidney stones or kidney stones on imaging and either i) successfully donated a kidney or ii) were declined for donation due to history of kidney stones, litholink abnormalities or imaging findings * willing to participate and sign an informed consent. exclusion criteria: * subjects who are currently pregnant or breast feeding.

Keywords: transplant
study to evaluate the safety and efficacy of abt-712 in subjects with moderate to severe chronic low back pain (clbp)

Conditions: Chronic Low Back Pain

Summary: the primary purpose of the study was to test the efficacy of 2 tablets (twice daily) of abt-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain (clbp).

the study used a randomized withdrawal design with an open label (ol) period prior to a double-blind (db) period. participants who were receiving benefit and were tolerating abt-712 during the ol period were randomized into the db period. study drug was given for a total of 8 weeks, which included up to 3 weeks in ol, up to 4 weeks in db, and a 1-week db taper. during the ol period, all participants took increasing doses of abt-712 until they were taking 2 tablets, twice daily. during the db period, participants in the abt-712 group took 2 abt-712 tablets, twice daily throughout the 4 weeks, while participants in the placebo group took 2 placebo tablets twice daily.

Eligibility criteria:
inclusion criteria: * adult male and female subjects who voluntarily sign the informed consent * diagnosis of clbp of 6 months duration exclusion criteria: * incapacitated or bedridden subjects * subjects with history of surgical or invasive intervention

Keywords: effect on sleep interference by pain