Kornimate/medical-research-clean huggingface dataset:
case-control study on matrix metalloproteinase levels in tissue in patients with keloid scar

Conditions: Keloid

Summary: purpose: to compare the levels of matrix metalloproteinase-1 (mmp-1), mmp-8, mmp-13 and tissue inhibitor of metalloproteinases (timps) in keloid skin tissue with normal skin in the same patient and with normal discarded skin tissue (control). the investigators aim to correlate between levels of mmps in patients with keloid scarring in comparison with normal and discarded tissue.

the investigators anticipate enrolling 20 patients into our study. the cost of the excision and related procedures will not be covered by the research study. patient and patient's health insurance provider will be responsible for all costs of treatment and related procedures. 1. patients must be at least 18 years old and have a keloid which they will agree to have biopsied. 2. during a screening visit we will obtain determine if patient fulfills inclusion/exclusion criteria, obtain informed visit and hipaa authorization. demographic information and pertinent medical history will be obtained and risk factors will be explained to the patient. 3. a focused dermatological exam will be performed assessing the severity and location of the keloid as well as skin phototype of the patient. 4. a henry ford hospital dermatosurgeon will excise a biopsy of the keloid tissue and normal tissue from enrolled patients and the specimens will be sent to the lab for workup. discarded skin samples will also be collected from henry ford plastic surgery and dermatology department and analyzed as an additional control for normal skin. the discarded skin samples (controls) will be region specific and matched with a keloid sample that is from the same area of the body as the biopsy sample. 5. levels of mmp's will be measured in keloid, normal tissue samples and discarded skin samples. 6. levels of timps will be measured in keloid, normal tissue and discarded tissue samples

Eligibility criteria:
inclusion criteria: * for inclusion, the subject must: 1. be at least 18 years old; 2. have a keloid and accept to have it excised; 3. be able to understand the requirements for the study, the risks involved and are able to sign the informed consent form; 4. agree to follow and undergo all study-related procedures exclusion criteria: * subjects will be excluded if any of the following apply: 1. women who are lactating, pregnant, or planning to become pregnant; 2. patients with a recent history of serious systemic disease; 3. patients who are receiving treatment for the keloid or have received treatment in the past 1 year. 4. any reason the investigator feels the patient should not participate in the study.

Keywords: keloid mmp matrix metalloproteinase dermatology
retrospective chart review of the 5 & 2 & 2 and 4 & 2 & 1 plans

Conditions: Obesity

Summary: the purpose of this study is to retrospectively and systematically review records of overweight and obese medifast weight control center (mwcc) members who have been assigned to the 5 \& 2 \& 2 plan or the 4 \& 2 \& 1 plan for weight loss to gain a better understanding of the effectiveness of these programs. the study will describe demographics of this population, along with weight loss, anthropometrics, body composition and effects on available cardiovascular parameters. adherence to the plans will also be examined. the study hypothesis is that the 5 \& 2 \& 2 meal replacement plan and the 4 \& 2 \& 1 meal replacement plan are both effective programs for weight loss in overweight and obese adults.


Eligibility criteria:
inclusion criteria: * adult males and females, 18 years of age or older at the start of the weight loss program. * subject has a bmi ≥ 25 kg/m2. * subject started a weight management program at the mwcc location on or after january 1, 2012. * subject followed the 5 \& 2 \& 2 plan or the 4 \& 2 \& 1 plan for at least the first two weeks of their weight loss phase while an active member of the mwcc. * subject signed the personal health information consent form. exclusion criteria: * subject was concurrently following another weight loss program other than the 5 \& 2 \& 2 plan or the 4 \& 2 \& 1 plan while on that respective plan. * subject had documented use of prescription or over-the-counter weight loss pharmacotherapy (e.g., phentermine, orlistat) concurrently with the 5 \& 2 \& 2 plan or the 4 \& 2 \& 1 plan. * subject completed initial consultation but did not participate in any follow-up visits. * subject is currently in the active weight loss phase of their program at the mwcc (subjects in the transition or weight maintenance phases of their programs are eligible.) * written request by subject to revoke consent to use health information is present in subject chart.

Keywords: obesity weight loss meal replacements weight maintenance
serum levels of vitamin d and il8 in patients with periodontitis

Conditions: Periodontal Diseases

Summary: we evaluated vitamin d and il8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis.

the primary objective of this study is to assess the levels of vitamin d and il8 in the serum of individuals diagnosed with periodontitis and compare them with those of a healthy control group. the study also aims to establish correlations between these serum levels and the degree of periodontitis severity. two groups will be recruited: patients diagnosed with periodontitis and a control group consisting of individuals without periodontal disease. the participants will be matched for age, gender, and other relevant demographic factors to minimize confounding variables. serum samples will be collected from both groups. periodontitis severity will be determined using established clinical indices, such as probing depth, clinical attachment loss, and bleeding on probing. vitamin d levels in the serum will be measured using standardized laboratory techniques. il8 levels in the serum will also be quantified using appropriate assays. statistical analyses will be performed to identify any significant correlations between vitamin d levels, il8 levels, and the severity of periodontitis. subgroup analyses may be conducted to explore potential variations based on demographic factors or other relevant variables. the study will adhere to ethical guidelines, ensuring participant confidentiality, informed consent, and responsible data handling. the study anticipates finding associations or correlations between serum levels of vitamin d and il8 and the severity of periodontitis. this information may contribute to a better understanding of the role of these factors in periodontal health and could have implications for future preventive and therapeutic strategies.

Eligibility criteria:
inclusion criteria: * presence of at least twenty teeth. * periodontitis patients with a minimum of 40% of sites with a clinical attachment level (cal) ≥2 mm and probing depth (pd)≥4 mm. * presence of ≥40% sites with bleeding on probing. * healthy individuals matched for age and gender, who presented no systemic disease, no drugs were taken, no sites with pd ≥4 mm or cal ≥4 mm, or radiographic signs of bone loss were enrolled, such as a control group. exclusion criteria * intake of contraceptives, immunosuppressive, antibiotics or anti-inflammatory drugs throughout the last three months prior to the study. * pregnant and lactating females. * diabetic patients. * history of medications that might affect bone and mineral metabolism and/or periodontal health. * taking multivitamins and food supplement which contain vitamin d. * malabsorption syndrome or patient with chronic diarrhea. * treatment with bisphosphonates in the past 12 months or lifetime exposure to bisphosphonates for more than 3 years.
flexi-bar and multi-component exercises

Conditions: Older Adults

Summary: background: previous studies have suggested that both flexi-bar and multi-component exercises can improve an individual's physical fitness and musculoskeletal discomfort. however, determining which is more effective in enhancing the frailty, physical fitness, and musculoskeletal discomfort of the elderly remains controversial. objective: this study aims to investigate differences in the effectiveness of flexi-bar and multi-component exercises in improving the frailty, physical fitness, and musculoskeletal discomfort of the elderly after 12 weeks of intervention. methods: a single-blind randomized controlled trial was conducted to collect data from a city in central taiwan. participants were randomly divided into a flexi-bar group (fb group) and a multi-component exercise group (mce group). participants in the fb group performed a 60-minute flexi-bar exercise every week for 12 consecutive weeks. meanwhile, participants in the mce group performed a 60-minute multi-component exercise every week for 12 consecutive weeks. tests were conducted both before and after the 12-week intervention using items including the kihon checklist, senior fitness test, and nordic musculoskeletal questionnaire.


Eligibility criteria:
inclusion criteria: * (1) participants aged 65 years and over; * (2) participants who could communicate in mandarin or taiwanese and cooperate with sports activities; and * (3) participants who could walk independently without assistance (or with aid). exclusion criteria: * (1) participants with unstable physiological conditions (or those who were recommended against participating in physical activities by their doctor); * (2) participants with unstable mental conditions; and * (3) participants who could not complete the 12-week exercise intervention.
prognostic value of early postoperative right ventricular systolic function in patients with isolated severe tricuspid regurgitation

Conditions: Tricuspid Regurgitation

Summary: preoperative right ventricular end-systolic area (rv-esa) and hemoglobin level were suggested as independent prognosticator for predicting long-term prognosis in patients with isolated severe tr undergoing corrective surgery we attempted to explore whether early postoperative echocardiography provides additional prognostic information on top of preoperative clinical and echocardiographic variables.

we prospectively recruited patients with isolated severe tr undergoing corrective surgery. comprehensive preoperative echocardiography was performed in all patients, with the performance of early postoperative echocardiography in all patients. during follow-up, clinical events, defined as operative mortality (death within 30 days after surgery or before discharge), cardiovascular death, repeated open heart surgery, and readmission due to cardiovascular problems were investigated.

Eligibility criteria:
inclusion criteria: * severe tricuspid regurgitation exclusion criteria: * concomitant left-sided valve surgery * significant coronary artery disease

Keywords: tricuspid regurgitation, severe
clinical evaluation of bass and treble controls for ci subjects

Conditions: Hearing Loss

Summary: the clinical study is designed to evaluate the safety and effectiveness of recipient controlled bass and treble.

bass and treble controls provide the ci recipient with access to the adjustment of low and high frequency sound balance, known as bass and treble respectively. the clinical study is designed to evaluate the safety and effectiveness of recipient controlled bass and treble. subjects will have access to the bass and treble controls during a 4 week take-home period, and will complete questionnaires and diaries to provide descriptive data on the bass and treble adjustments made during take home use, and the success of these adjustments. pre and post intervention speech test results will be used to evaluate the effect of access to bass and treble controls on speech perception. the post intervention questionnaire will provide information on the overall ratings of the bass and treble controls.

Eligibility criteria:
inclusion criteria: 1. six years of age or older 2. at least 3 months experience with the cp810, cp910 or cp920 sound processor 3. at least 3 months experience with the ci24re or ci500 series implant 4. willingness to participate in and to comply with all requirements of the protocol exclusion criteria: 1. unrealistic expectations on the part of the subject, regarding the possible benefits, risks and limitations that are inherent to the procedure and prosthetic device 2. additional disabilities that would prevent participation in evaluations
nosocomial and community acquired legionella pneumophila pneumonia.

Conditions: Legionnaires' Disease

Summary: legionnaire's disease (ld) is a major cause of both community acquired and nosocomial pneumonia, with legionella pneumophila serogroup a (lp1) being the most virulent and the greatest cause of disease. sample culture of low respiratory tract is considered the gold standard in the diagnosis of ld, however its sensitivity seems to be poor and its performance is technically demanding. the introduction of urinary antigen detection testing (lua) brought a major advance in ld diagnosis, with upt to 95% of cases in europe being diagnosed with this method. despite the high sensitivity of lua for lp1, ranging from 80-90%, its negative predictive value is low in other serogroup than lp1 and therefore, legionella may be unrecognized as agent of pneumonia. although underdiagnosed and underreported, ld represents the second most common cause of pneumonia requiring admission in intensive care unit (icu). average fatality rate of ld in europe reaches 10%, but its mortality is considered to be even higher in nosocomial patients. despite the higher fatality rate in hospitalized ld patients, poor is the knowledge on the risk factors that could induce disease and that increase mortality in the hospitalized population affected by ld. in order to shed more light on this topic a cohort of patients diagnosed with ld in the last 3 years will be retrospectively examined.


Eligibility criteria:
inclusion criteria: all confirmed human cases of legionnaires' disease diagnosed within the chu brugmann hospital within the last 3 years, from 01/01/2016 till 31/12/2018. a similar approach will be followed for the st pierre and the uz brussel hospitals. exclusion criteria: pregnant women.
maternal and fetal outcomes in pregnant women with liver disease

Conditions: Fulminant Hepatic Failure

Summary: liver disease complications during pregnancy can impact maternal and neonatal health, though not many studies are on view to investigate maternal and fetal outcomes in pakistani pregnant women. so, this study was aimed to determine the maternal and fetal outcomes among pregnant females with liver disease.


Eligibility criteria:
inclusion criteria: * pregnant females with liver disease * with gestational age \> 24 weeks * any parity or gravidity status exclusion criteria: * pregnant females with renal disease or any kind of malignancy
marginal bone changes around dental implant placed with open vs. closed sinus elevation

Conditions: Marginal Bone Levels; Open Sinus Elevation; Closed Sinus Elevation

Summary: background: in cases with atrophic posterior maxilla, sinus elevation techniques are essential for a successful implant placement. the optimal strategy for treating pneumatized maxillary sinus in terms of dental implant insertion and surrounding bone stability has been a scientific conundrum for many years. the objective of this study was to evaluate and contrast the long-term marginal bone alterations around dental implants that were positioned utilizing transcrestal (closed) versus lateral (open) sinus elevation procedures. material and methods: fifty six dental implants were inserted for patients with inadequate residual bone height due to maxillary sinus pneumatization after receiving approval from suez canal university's ethics council. depending on the method, these patients were randomly assigned to one of two groups: the test group, which received the closed sinus elevation, or the control group, which received the open sinus elevation.allogenic bone grafting was used to treat the elevated sinuses in both groups.the mesial and distal marginal bone loss for these dental implants was evaluated over a 12-month period following surgery using a standardized digital periapical radiography and the cliniview software to measure radiographic bone alterations.


Eligibility criteria:
inclusion criteria: * patients who have at least one missing posterior maxillary tooth with sound adjacent teeth. * adults above the age of 18. * bone height from 4mm to 7mm under the maxillary sinus assessed in cbct. * good oral hygiene. * patient accepts to sign an informed consent. exclusion criteria: * smokers (more than 10 cigarettes per day). * medically compromised patients. * patients with active infection related at the site of implant/bone graft placement. * patients with untreated active periodontal diseases. * patients with parafunctional habits. * acute or chronic sinusitis.

Keywords: dental implants bone loss maxillary sinus floor augmentation. bone-implant interface bone resorption,
acupuncture in persistent atrial fibrillation

Conditions: Persistent Atrial Fibrillation

Summary: the aim of this trial is to evaluate the effect of acupuncture on prevention of atrial fibrillation (af) recurrence after electrical cardioversion (ec) for persistent af patients resistant to the antiarrhythmic drugs (aads).

this is a multicenter, prospective, participant and assessor blinded, randomized, sham-controlled clinical trial with 2 parallel arms. to evaluate the efficacy and safety of acupuncture, a total of 80 persistent af participants will be recruited and randomly assigned to active acupuncture and sham acupuncture group. both group commonly take antiarrhythmic medication during study period. these patients who are resistant to drug therapy will get a electrical cardioversion. after cardioversion, the recurrence rate and duration of atrial fibrillation free time will be evaluated. this trial consists of 2 weeks of observation and medical therapy, 2 weeks of acupuncture intervention before ec, ec and acupuncture intervention, 7 weeks of additional intervention, and 5 weeks of follow-up. after randomization, participants receive 10 sessions of acupuncture treatments over 10 weeks. the outcome is assessed at 2, 4, 6, 8, and 16 week after randomization.

Eligibility criteria:
inclusion criteria: * persistent af lasting ≥ 7 days * ages in 20-75 years * resistant with antiarrhythmic drugs * written informed consent exclusion criteria: * age below 20 years or above 75 years * severe valvular heart disease * history of open heart surgery * history of treatment for myocardial infarction (mi) within recent 6 weeks * patients under or requiring the administration of antiviral drugs * 2nd degree atrioventricular block or more than two fascicular block * severe pulmonary, liver, or renal disease * previous acupuncture treatment for cardiovascular condition within 3 months

Keywords: atrial fibrillation acupuncture recurrence electrical cardioversion
phase iii placebo-controlled study of v260 (rotateq™) in japanese healthy infants (v260-029)(completed)

Conditions: Rotavirus; Gastroenteritis

Summary: the purpose of the study is to evaluate whether v260 is effective and well tolerated in japanese healthy infants.


Eligibility criteria:
inclusion criteria: * healthy japanese infants, 6 weeks through 12 weeks of age exclusion criteria: * history of known prior rotavirus gastroenteritis * subjects who are concurrently participating in or are anticipated to participate in other studies of investigational products at any time during the study period

Keywords: gastroenteritis rotavirus
examining the effect of role-playing exercise by utilizing an obesity suit in a simulation scenario on weight bias and empathy levels among nutrition sciences students

Conditions: Obesity; Bias, Weight

Summary: a quasi-experimental design (i.e., "one-group pretest-posttest design") will be applied among 34 convenient samples of undergraduate students in their first year of nutrition sciences program at ariel university and tel-hai college. the intervention will take place at the simulation centers of the institutions. all participants will be asked to wear an obesity simulation suit (unisex obesity simulation suit, erler-zimmer, germany) and to participate in a standardized scenario that simulates meetings between a person with obesity and a 'registered dietitian'. the 'registered dietitian' will be presented by a professional role-player and the scenario will encompass different levels of weight bias. at baseline, 1- and 3-week post-intervention both groups will be asked to fill in a survey using "qualtrics" software. the survey will include the anti-fat attitudes questionnaire (afa), the short-form of fat-phobia scale (f-scale), the weight-implicit association-test (weight-iat), and the jefferson scale of empathy. data on demographics, weight history, and perception, measurement of actual weight and height, and the beliefs about the causes of obesity questionnaire will be collected at baseline.


Eligibility criteria:
inclusion criteria: * undergraduate students in their first year of the nutrition sciences program at ariel university or tel-hai college * age ≥18 years * having fluency in hebrew * ability to wear an obesity suit * willingness to participate in the study
sensor validation study - quality assurance

Conditions: Respiratory Rate

Summary: the respiratory rate is an important parameter in clinical medicine. it is defined as the number of breaths per minute. currently this is measured at the bedside in clinical practice by counting the breaths, however the gold standard for measuring this vital sign is the capnograph. for the patient, this involves wearing a tube in their nose and around their ears while trying to minimise their movement and talking so that the measurements can be taken. a new respiratory rate monitor, respirasense, is non-invasive and measures the respiratory rate by measuring the displacement between the ribs and abdomen. this research study is intended to validate that this technology is effective and accurate on people with a bigger body mass. subjects with a bmi \> 35 will be invited to participate should they meet all of the eligibility criteria. if patients agree to participate, following informed consent, subjects will be monitored for one hour with both the capnograph and respirasense measuring at the same time so their results can be compared


Eligibility criteria:
inclusion criteria: * ≥ 18 years * have a bmi ≥35 * for the sub-group analysis at least 5 subjects with a bmi 35-49 and at least 5 bmi \> 50 will be needed * are willing to voluntarily sign a statement of informed consent to participate in this investigation exclusion criteria: * allergic to medical grade skin adhesive * continuous oral long term steroid use. to be free from oral steroid use this is defined as not using oral steroids in the 4 weeks previous to enrolment * patients under the influence of substance abuse (drug or alcohol) that may interfere with their ability to cooperate and comply with the investigation procedures * any disorder, including cognitive dysfunction, which would affect the ability to accurately complete questionnaires and freely give full informed consent