Kornimate/medical-research-clean huggingface dataset:
efficacy of selective laser trabeculoplasty targeting nasal versus inferior 180-degree

Conditions: Open Angle Glaucoma

Summary: the purpose of this study to optimize selective laser trabeculoplasty (slt) application when used in the management of open angle glaucoma (oag)

the purpose of this research is to determine the most effective method in using selective laser trabeculoplasty (slt) for lowering intraocular pressure (iop) in patients with ocular hypertension or open-angle glaucoma. we will investigate the iop lowering differences between nasal 180° slt and inferior 180° slt,. the second stage will assess the effect of repeating slt in the opposite 180° sector after 3 months.

Eligibility criteria:
inclusion criteria: * age 18 years and older * ability to comprehend the study procedures and agreement to proceed with primary slt treatment * diagnosis of primary or secondary open angle glaucoma or glaucoma suspects with ocular hypertension * bilateral disease * pre-slt iop \>21 mmhg measured at least twice during patient's lifetime with or without medication * open angles with moderate to intense trabecular pigmentation * mild to moderate visual field defects (24-2 standard mean deviations better than the swedish interactive thresholding algorithm standard of 12 db) * no adequate iop control (low treatment compliance, substantial adverse effects with eyedrops, and at least 2 iop measurements higher than the individualized target iop) exclusion criteria: * unwilling or unable to give consent * unable to attend scheduled post-operative visits * previous history of either laser treatment or intraocular surgery, except for non-complicated cataract surgery (performed \>6 months before slt) * history of ocular trauma * narrow angles * retinal detachment * active iris neovascularization or active proliferative retinopathy * active uveitis * monocular patients * current use of steroids (ocular, periocular, or systemic)
long-term treatment study of cdp870 self-injection in patients with active rheumatoid arthritis who are participating in the long-term treatment studies (study 275-08-002 or study 275-08-004) of cdp870

Conditions: Active Rheumatoid Arthritis

Summary: the objective of this study is to evaluate the safety and efficacy of cdp870 self-injection administered for 24 weeks or longer in subjects who are participating in the long-term treatment study (study 275-08-002 or study 275-08-004) of cdp870 administered concomitantly with or without methotrexate.


Eligibility criteria:
inclusion criteria: * subjects who have completed the treatment in the parent clinical studies (nct00851318 and nct00850343) up to 52 weeks * subjects who are willing to undertake self-injection and provide a written consent exclusion criteria: * patients with serious adverse events * patients who are judged by the investigator/subinvestigator to be ineligible to participation in the study for reasons such as uncooperative attitude or nonadherence to study procedures.

Keywords: cdp870 rheumatoid arthritis long-term
solx gold shunt for refractory glaucoma

Conditions: Glaucoma; Glaucoma, Open Angle

Summary: to establish the clinical performance of the solx gold shunt for its ability to reduce intraocular pressure (iop) in eyes with refractory glaucoma where medical and conventional surgical treatments have failed.


Eligibility criteria:
inclusion criteria: * primary open-angle glaucoma * age 21 or over * refractory glaucoma, with iop ≥ 24 mmhg on medications and failed prior incisional glaucoma surgery * detectable visual field defect (negative md score) * written informed consent * available for up to 24 months follow-up exclusion criteria: * either eye with va worse than count fingers * angle closure glaucoma episode within past 12 months * uveitic glaucoma, iridocorneal endothelial (ice) syndrome, traumatic glaucoma, or neovascular glaucoma * diagnosis of pigmentary glaucoma or pseudoexfoliative glaucoma * other significant ocular disease, except cataract * active ocular infection * expected ocular surgery in next 12 months * no suitable quadrant for implant * systemic corticosteroid therapy \> 5 mg/day prednisone * intolerance to gonioscopy or other eye exams * mental impairment interfering with consent or compliance * pregnancy * known sensitivity to anticipated medications used at surgery * significant co-morbid disease * concurrent enrollment in another drug or device study

Keywords: glaucoma shunt ocular implant gold trabeculectomy
alcohol & mobile phone study to reduce high-risk alcohol use and consequences

Conditions: Alcohol; Use, Problem

Summary: the proposed study will develop a smartphone/mobile app intervention that incorporates ecological momentary assessment (i.e., two brief surveys per day) and daily intervention messaging (2 messages per day) for three weeks to target high-risk alcohol use among young adult college students. the intervention mainly focuses on alcohol expectancies, alcohol use, and consequences and the daily associations between these and includes personalized intervention messages based on participants' own event-level expectations and experiences. other psycho-educational alcohol-related content is also provided over the course of three week intervention. this mobile app intervention will be used in a randomized controlled trial (rct) comparing young adult college students who receive the intervention with those who only receive assessments via the mobile app.

the purpose of this study is to develop and test a smartphone app that can both collect daily data and deliver a personalized intervention using participants' own event-level, real-world experiences to challenge proximal alcohol expectancies and alter the associations between alcohol expectancies and drinking and consequences. the mobile app intervention will be used in a randomized controlled trial comparing young adult college students who receive the intervention with those who only receive assessments via the mobile app. assessments include an eligibility survey, baseline assessment, and follow-up assessments occurring 1-, 6-, and 12-months post-intervention. the goal of the intervention is to target college students' alcohol expectancies (what they believe or expect alcohol's effects to be) and the associations between alcohol expectancies and alcohol use and related consequences. intervention content will utilize twice daily messages, one in the morning (am messages) and one in the late afternoon or early evening (pm messages). most pm messages draw on information collected in the daily assessments (personalized messages). intervention messages in general will include feedback based on selected assessment items, weekly summaries generated from the daily assessments, general psycho-educational messages and videos about alcohol, and a toolbox with content that supplements information provided in the daily intervention messages.

Eligibility criteria:
inclusion criteria: * typically drinking 2+ days/week, having at least 1 occasion of heavy episodic drinking (4+ women/5+ men) in last 2 weeks, having 4 or more negative consequences in the last month, owning a smartphone with a data package, agreeing to install the app on their phone and receive notifications. * student at a 2- or 4- year college where recruitment is located exclusion criteria: * none
late cerclage in high-risk pregnancies (latch)

Conditions: Premature Birth

Summary: the goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (tvu) cervical length (cl) ≤25mm between 24 0/7-26 6/7 weeks.

singleton high-risk pregnancies \< 24 weeks of gestation will be screened for enrollment and randomized, if a short tvu cl (≤25mm) is detected between 24 0/7 - 26 6/7 weeks, to either cervical cerclage or control (no cerclage). aside from cerclage placement, management of included women will be the same including recommendation for continuing or initiating daily vaginal progesterone 200mg from randomization until 36 6/7 weeks. the primary outcome will be the incidence of preterm birth \<37 weeks.

Eligibility criteria:
inclusion criteria: * 18-50 years old, pregnant, assigned female at birth * singleton pregnancy * tvu cl ≤25mm between 24 0/7 - 26 6/7 weeks of gestation exclusion criteria: * initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed \>14 weeks, or cotwin pregnancy loss diagnosed \>14 weeks * cerclage in situ * preterm labor, defined as painful regular uterine contractions and change in cervical dilation * pprom * active vaginal bleeding * suspected intraamniotic infection * major fetal structural abnormality or chromosomal disorder * placenta previa or accreta * other contraindication to cerclage placement * participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone

Keywords: cervical length short cervix shortened cervix prematurity preterm birth viability
study of weight-reducing effect and safety of rimonabant in obesity in asia (rio-asia)

Conditions: Obesity

Summary: primary : effect on weight loss and weight maintenance over 9 months when prescribed with a hypocaloric diet in obese patients. secondary : effect on hdl-cholesterol, triglycerides, fasting-insulin, fasting glucose, waist circumference - safety and tolerability


Eligibility criteria:
inclusion criteria: * body mass index (bmi)\> 25 kg/m² exclusion criteria: * absence of stable weight (variation \< 5 kg) within three months prior to screening visit), * absence of effective contraceptive method for females of childbearing potential, * presence of treated or untreated type 1 or type 2 diabetes, * systolic blood pressure \> 165 mm hg and/or diastolic blood pressure \> 105 mm hg on 2 consecutive visits from the screening to the inclusion visit, * presence of secondary hypertension, * patients with conditions/concomitant diseases making them non evaluable for the primary efficacy endpoint (presence of any clinically significant endocrine disease according to the investigator, obesity of known endocrine origin...) * presence of any severe medical or psychological condition or chronic conditions/infections that in the opinion of the investigator would compromise the patient's safety or successful participation in the study, * presence of any clinically significant abnormality according to the investigator on the ecg performed on the inclusion visit. * presence or history of cancer within the past five years with the exception of adequately treated localized basal cell skin cancer or in situ uterine cervical cancer. * related to previous or concomitant medications : * drugs affecting weight (e.g., sibutramine, orlistat, herbal preparations, etc). * antidiabetic drugs. * related to laboratory findings: * positive test for hepatitis b surface antigen and/or hepatitis c antibody. * abnormal tsh level (tsh \> uln or \< lln). * positive urine pregnancy test.

Keywords: obesity
propofol for prophylaxis of morphine induced pruritis in caesarean section

Conditions: Pruritus Caused by Drug

Summary: the goal of this randomized clinical trial is to find the optimum sub hypnotic dose of iv propofol that prevents the incidence of itching induced from intrathecal morphine used in spinal anesthesia in caesarean section operation. the main questions it aim to answer are the number of patients complained of pruritus in the first 24 hours post operative period and the severity of the pruritus. participants will be divided into 4 groups. 1st group receives 0 mg of propofol , 2nd receives 10 mg , 3rd receives 20 mg and the 4th receives 30 mg.


Eligibility criteria:
inclusion criteria: 1. the study is scheduled for women undergoing elective caesarean section under spinal anesthesia. 2. the subject is ≥ 20 years and ≤ 40 years. 3. no obvious abnormalities in preoperative ecg, blood routine, electrolytes, and other tests. 4. asa class 1-2. exclusion criteria: * patients who had a known allergy to propofol, morphine, or bupivacaine. * those with preexisting pruritus caused by pregnancy, a coexisting skin disorder, or other pruritogenic systemic diseases. * patients with a contraindication to spinal anaesthesia * failed block * need of extra sedation intra-operative * positive history for asthma or copd. * patient refusal

Keywords: morphine induced pruritus
probiotic-enriched artichoke in functional constipation

Conditions: Functional Constipation

Summary: the aim of the present randomized double-blind controlled crossover study is to compare the effects of the 15-day consumption of artichokes enriched with the probiotic lactobacillus paracasei lmgp22043 with those of ordinary artichokes on treatment preference, satisfactory relief of symptoms, bowel habit and the modulation of scfa production in a group of patients suffering from functional constipation.

functional constipation is a common problem in westernized societies and is characterized by different gastrointestinal symptoms.different therapeutic strategies have been proposed, but a new therapeutic approach for constipation could be based on the modulation of intestinal microflora by administering prebiotics and/or probiotics. currently, probiotic products are mainly incorporated in fermented milk-based products or concentrated probiotic preparations. to enlarge the range of choice and to exploit the nutritional qualities of plant matrices, an innovative line of probiotic vegetable products such as artichokes has been developed. the use of these vegetables containing live probiotic strains can take advantage of some their peculiar features for growth and improved bacterial survival. artichokes can, therefore, work as valid "active" vehicles for the transport and release of adequate amounts of bacterial populations.

Eligibility criteria:
inclusion criteria: * fulfilment of the rome criteria iii for constipation * availability of at least one gi imaging study during the last five years(colonoscopy, sigmoidoscopy, abdominal ultrasound, barium enema) * commitment to availability for the whole study period exclusion criteria: * major abdominal surgery * the presence of any concomitant diseases such as organic gi diseases including lactose and gluten intolerance; medical or psychiatric illness * alarming symptoms (rectal bleeding, weight loss, etc) * family history of peptic ulcer, colorectal cancer, or ibd; * abnormal laboratory data or thyroid function.

Keywords: artichokes constipation functional foods prebiotics probiotics
comparison of two acl reconstruction techniques: all-inside versus complete tibial tunnel technique

Conditions: Anterior Cruciate Ligament Tear

Summary: this study intends to perform an all-inside and complete tibial tunnel acl reconstruction technique in 80 patients, and compare the clinical and radiological outcomes of the two surgical procedures through follow-up.

this is a prospective randomized, controlled, single-center clinical trial study on acl reconstruction surgery technique. in this study, 80 patients with acl rupture were recruited according to the enrollment criteria. the recruited patients were randomly divided into groups. the ratio of the control group is 1:1. in this study, 40 patients with acl rupture in the experimental group will be treated with all-inside reconstruction technique, and 40 patients with acl rupture in the control group will be treated with complete tibial tunnel technique. all operations will be performed with 4-strand autologous semitendinosus tendon. all fixations will be performed using an adjustable cortical suspensory system. after reconstruction, all subjects will participate in the collection of clinical function scores including marx activity score, ikdc score, and clinical evaluation including physical examination, joint laxity, ct and mri imaging analysis.

Eligibility criteria:
inclusion criteria: * patients who have provided informed written written consent; * patients aged between 18 and 45; * patients undergoing reconstructive surgical treatment of the anterior cruciate ligament (acl) * patients undergoing acl reconstruction with a 8 mm four-strand semitendinosus autograft exclusion criteria: * patients who have not signed informed consent; * patients undergoing any additional concomitant ligament repair or reconstruction at the same surgery * revision procedures * patients unable to lay still in an mri or ct scanner * patients with a torn acl or previous acl reconstruction in the contralateral knee. * patients who had an excessive tibial slope \>12 degrees
a study of the effects of physiotherapy to prevent pelvic organ prolapse

Conditions: Pelvic Organ Prolapse

Summary: pelvic organ prolapse is a problem experienced by women where a bulge comes down in the vagina, and may even drop down outside the vagina. the bulge in the vagina is caused by other organs moving down from their normal position in the pelvis and pushing into the vagina. this is a very common problem and many women who have given birth will have a very mild bulge which does not cause them symptoms. women can however experience a variety of pelvic, bladder, bowel and sexual symptoms which impact on daily life. no research studies have properly examined whether or not exercises can prevent prolapse. this study aims to explore whether exercises taught by a physiotherapist can prevent women developing a prolapse which requires them to have treatment.


Eligibility criteria:
inclusion criteria: women involved in the prolong study who: * have some evidence of vaginal laxity in any compartment (pop-q stage i, ii or iii) * have had no previous treatment for prolapse (surgery, pessary, pfmt) women must be willing to participate in the trial and to comply with their group allocation. exclusion criteria: women: * with stage 0 or iv prolapse * who have had previous incontinence surgery (except mid-urethral sling operation) * who have had previous formal instruction in pfmt for any diagnosis in preceding five years * who are pregnant, or delivered a baby within the last six months * who are unable to comply with pfmt treatment * who are unable to give informed consent

Keywords: prevention pelvic floor muscle training prolapse symptoms urinary symptoms sexual function randomised controlled trial
tai chi versus conventional exercise to alleviate depression in insomniacs

Conditions: Depressive Symptoms; Chronic Insomnia

Summary: this study aims to examine the effectiveness of tai chi and conventional exercise in alleviating depressive symptoms in older insomniacs.

chinese community-dwelling older adults with mild-to-moderate depressive symptoms and chronic insomnia will be recruited. eligible participants will be randomized to health education control, tai chi or conventional exercise interventions on a 1:1:1 basis after baseline assessment. all interventions will last for 3 months. outcomes will be assessed at baseline, at 3 months and at 6 months after the completion of the intervention.

Eligibility criteria:
inclusion criteria: * 60 years or older * can communicate using cantonese or mandarin * with mild-to-moderate depressive symptoms (hads-depression score ≥8/21 and phq- 9 score ≤14/27) * fulfil the fifth edition of diagnostic and statistical manual of mental disorders (dsm-5) criteria for chronic insomnia including difficulties in initiating or maintaining sleep, early morning awakening with complaint of significant distress or impairment of daytime functioning, sleep difficulty occurring at least three nights per week and present for at least 3 months. exclusion criteria: * somatic condition that prevents participation in tai chi or exercise * regular moderate-to-vigorous intensity exercise or mind-body training such as tai chi, yoga, qigong or meditation in the past 3 months * any form (or combination) of exercises amounting to 180 minutes per week in the past 3 months * dementia * diagnosis with schizophrenia or other psychotic disorders, bipolar disorders or alcohol/substance use/abuse * current usage or planning to use potentially confounding treatments, including herbal supplementations (e.g., st. john's wort), acupuncture treatment, cognitive behavioral therapy or other psychotherapy, mind-body intervention (e.g., mindfulness training and muscle relaxation training) or muscle relaxants such as carisoprodol, cyclobenzaprine, diazepam * current suicidal or self-injurious potential that requires immediate clinical follow-up.

Keywords: exercise tai chi elderly depression insomnia
exploring unmet needs and attitudes to skin self-examination in melanoma survivors

Conditions: Melanoma, Stage I; Melanoma Stage III; Melanoma, Stage II

Summary: this is a prospective, multi-centred cohort study whereby the eunass study questionnaire will be administered electronically to identify needs of melanoma survivors, the extent to which these needs are being met, and identify areas which have the greatest need for development. it will also evaluate behaviour in relation to sun protection and skin self-examination (sse). it will be a self-completed questionnaire. qualitative work using semi-structured interviews will explore the needs of melanoma survivors in greater depth, will present examples of potential interventions to improve sse and explore factors that determine the likelihood of engaging in an intervention which can address unmet needs, such as improving sse. taken together, the data will provide the evidence base to inform the development of an intervention to improve sse, which can subsequently be tested in secondary care services.


Eligibility criteria:
inclusion criteria: participant is willing and able to give informed consent for participation in the study. * male or female, aged 18 years or above. * histological diagnosis of primary cutaneous invasive melanoma (any breslow thickness) at 3 - 12 months from diagnosis (as most primary treatment will be complete by 3 mths) * american joint cancer committee version 8 \[2018\] (ajcc v8) stage i - iii melanoma at time of recruitment * able to complete an electronic questionnaire exclusion criteria: * other current active internal malignancy (i.e. does not include non-melanoma skin cancers) * inability to independently complete electronic questionnaire * ajcc v8 stage iv melanoma at time of recruitment * clinical stage of disease unknown / unconfirmed
optimization of catheter insertion site for continuous peripheral nerve blocks

Conditions: Upper-extremity Surgery; Post-operative Pain

Summary: this research study is to determine if the insertion site of a perineural catheter or tiny tube placed next to the nerves that go to the part of the body (hand or arm) having surgery, affects the amount of pain relief that is experienced after surgery. catheters will be placed in either the supraclavicular or infraclavicular location.

to determine if a particular perineural local anesthetic catheter location (supraclavicular or infraclavicular) will maximize postoperative analgesia, minimize oral opioid requirements, minimize sleep disturbances resulting from postoperative pain, and maximize patient satisfaction.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * unilateral, upper (at or distal to the elbow) extremity orthopedic surgery with moderate-to-severe postoperative pain expected * patients already agree to and want a continuous brachial plexus block for postoperative analgesia exclusion criteria: * patients who have difficulty understanding the study protocol or caring for the infusion pump/catheter system * patients who have any known contraindication to study medications * insulin-dependent diabetes mellitus * neuropathy of any etiology in the affected extremity * contraindication to regional blockade (e.g. clotting deficiency) * any known acute or chronic hepatic or renal insufficiency or failure * any incision site outside of the catheter-effected area * chronic opioid use * history of opioid abuse * obesity * pregnancy * incarceration * inability to communicate with the investigators and hospital staff

Keywords: pain surgery catheter nerve block supraclavicular infraclavicular ucsd moderate-to-severe pain supraclavicular catheter infraclavicular catheter