Kornimate/medical-research-clean huggingface dataset:
natural history of atherosclerosis

Conditions: Atherosclerosis

Summary: 20 patients will be recruited. the aim of the study is to determine the natural progression of atherosclerotic disease.


Eligibility criteria:
inclusion criteria: * stable carotid artery disease not requiring revascularization * asymptomatic carotid artery stenosis \< 80% or symptomatic patients with stenosis \< 60 % * prophylactic therapy with aspirin (\> 100mg/day, statin, blood pressure therapy if indicated (goal \< 130/80 mmhg)) * informed consent exclusion criteria: * non atherosclerotic occlusive disease (bürgers disease) * uncontrolled bp (dbp \> 110 mmhg and/or sbp \> 200 mmhg) * hemorrhagic disease or platelet count \< 100'000 mm\^3 * known active liver disease (elevations of gpt got or increased ammonia) * impaired renal function (crea \> 180 mmol/l) * pregnancy * severe claustrophobic reactions * short - term life - threatening pathology * physically unable to participate in the study * compliance not guaranteed

Keywords: atherosclerotic disease progression natural progression of atherosclerotic disease natural history of atherosclerosis at the level of the carotid artery as evaluated by mri
tweesteden mild stenosis study

Conditions: Coronary Artery Disease; Non-significant Coronary Artery Disease; Mild Stenosis; Vascular Irregularities

Summary: psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes. patients with non-significant coronary artery disease (confirmed vascular irregularities, but \<60% coronary occlusion) often present with complaints such as chest pain, which warrant screening by coronary angiography (cag) or computed tomography (ct scan). the prognosis of this group of patients with mild stenosis remains to be investigated in more detail, and we propose that psychosocial factors play a role in the clinical prognosis and patient reported outcomes in this group. a special focus lies within examining personality characteristics, of which type d personality is a primary predictor variable for prognosis. type d personality is characterised by high negative affect and high social inhibition. in addition to psychosocial factors (personality, mood state, social support, ses), biomarkers(inflammation, clotting, dna) as well as standard clinical risk factors (metabolic syndrome, activity level, smoking, medication use, disease severity) will be investigated. the goal of the proposed study is to investigate a preexisting psycho-biochemical risk profile for major adverse cardiovascular events (mace) and patient perceived symptoms in a group with angiographically or ct-scan confirmed, non-significant coronary artery disease.


Eligibility criteria:
inclusion criteria: * based on quantitative coronary angiography (cag): visible, but non-significant (\<60% coronary occlusion) vascular irregularities and mild coronary stenosis. * based on 64-slice ct-scan (ct-scan): detected non-significant stenosis (calcium score \>= lowest 10th percentile), and not eligible for cag. exclusion criteria: * normal coronary arteries (based on cag or ct scan) * significant occlusion of coronary arteries (\>=60% stenosis) * eligible for coronary intervention such as pci or cabg * history of coronary events (being either mi,pci, cabg, heart failure) * for the ct-screened group: eligible for cag based on the ct-scan * serious comorbid conditions such as chronic kidney failure, or receiving chemotherapy * insufficient knowledge of the dutch language

Keywords: coronary artery disease atherosclerosis coronary stenosis cardiovascular diseases non-significant coronary artery disease mild stenosis vascular irregularities psychosocial factors personality type d personality hostility depression anxiety fatigue social support socioeconomic status patient reported outcomes patient perceived symptoms health status quality of life chest pain cardiac risk factors metabolic syndrome bmi obesity waist circumference lifestyle smoking alcohol use activity hypertension diabetes familial cardiovascular disease coronary angiography computed tomography
safety of eus-fna for pancreatic solid-pseudopapillary neoplasm (spn) before surgical resection: the spn-graphe series

Conditions: Solid Pseudopapillary Tumor

Summary: solid-pseudopapillary neoplasm (spn) is a rare type of pancreatic neoplasm. a cytopathological diagnosis is often mandatory before performing surgical resection. endo-ultrasonography with fine needle aspiration (eus-fna) improve significantly pre-operative spn diagnosis accuracy. so far, few eus-fna performed for spn were published, and safety of eus-fna for spn has never been investigated. this retrospective european multicenter case-control study compared the recurrence rate in patients with and without eus-fna performed before primary tumor resection.

this european multicenter study was conducted in 22 digestive units from the graphe (french taskforce of gastroenterologists working on digestive endoscopy: groupe de réflexion et d'action des praticiens hépatogastroentérologues en endoscopie digestive), and retrospectively included all patients who have undergone complete resection of their pancreatic spn from 2000 to 2018. the use of the diagnostic filing software of each unit of cytopathology, endoscopy and digestive surgery allowed the completeness of the prospection in each center. the data were retrospectively collected by extraction from our medical patient management softwares. the following data were collected: age, gender, symptoms, tumor size, tumor location (uncus, head, isthmus, body or tail of the pancreas), presence of tumor calcifications, performing of a eus-fna for diagnostic purposes before surgical resection, follow-up, and diagnosis of recurrence of the spn during follow-up. other data were collected in case of eus-fna: path of the needle puncture (transgastric or transduodenal), diameter of the needle, number of passes, immediate eus-fna morbidity, and eus-fna diagnosis of spn (certain, probable, false or absent). patients with and without initial eus-fna were compared and the main criteria of this study was determinate: the presence of recurrence of the spn during follow-up.

Eligibility criteria:
inclusion criteria: * all consecutive patients who have undergone complete resection of their pancreatic spn were included. inclusion criterion was the definite diagnosis of spn on the pathological examination of the complete tumor resection specimen. exclusion criteria: * no

Keywords: eus-fna
comparison between low dose and high dose intra-articular tranexamic acid in total knee arthroplasty

Conditions: Blood Loss, Surgical

Summary: the purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind rct


Eligibility criteria:
inclusion criteria: * osteoarthritic knee who underwent primary total knee arthroplasty exclusion criteria: * abnormal coagulation or bleeding disorder * allergy to tranexamic acid * history of thromboembolism or ischemic heart disease or cerebrovascular accident * chronic kidney disease stage 3-4

Keywords: blood loss tranexamic acid total knee arthroplasty topical administration
nicotine dependence, withdrawal and replacement therapy assessed by pet imaging

Conditions: Nicotine Dependence

Summary: the proposed research will provide significant new gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine replacement therapy (nrt). the studies will help to explain the differences in the prevalence of smoking in men and women, sex-specific differences in nicotine craving and withdrawal as well as the poorer therapeutic response to nrt. this work may pave the way to the design of improved pharmacotherapies that can more effectively target the endogenous opioid system in the treatment of nicotine dependence.

while smoking prevalence has declined for both men and women over the last two decades, rates among women have shown a much shallower decrease and, in recent years, prevalence of cigarette initiation has been higher for girls than boys. smoking among women of child-bearing age has significant negative health consequences for mother and child, increasing fetal and infant morbidity and mortality. women are both less likely to initiate a quit attempt and more likely to relapse if these women do quit. nicotine replacement therapy (nrt), still the most widely used smoking treatment intervention in the united states, is less effective for women compared with men, and women report less craving reduction on nrt. the endogenous opioid system is involved in smoking initiation, nicotine craving and reward as well as nicotine withdrawal symptoms. interestingly, research suggests that sexual dimorphic features of the endogenous mu-opioid system may in part explain gender differences in nicotine effects. to better understand the role of the mu-opioid system in poorer nrt responses in women, this proposal will examine nrt effects on mu opioid receptor binding potential (mor bp) in female compared to male smokers during active versus placebo nrt. specifically, nicotine dependent women and men in active smoking status will undergo pet imaging for mor bp measurement using 11c-carfentanil. following baseline pet measurement in active smoking (scan 1), smokers will be randomized to active or placebo nicotine replacement therapy ((a-nrt or p-nrt); 72 hours later, a second scan will be obtained. as a reference group, demographically-matched women and men who have never smoked will undergo two scans as well. behavioral measurements of nicotine reward, craving and withdrawal will be obtained repeatedly across the protocol. the proposed research will provide significant new, gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine replacement therapy.

Eligibility criteria:
inclusion criteria: * 21 - 60 years old * must meet dsm-iv criteria for nicotine dependence and be actively smoking exclusion criteria: subjects must meet study guidelines for medical and mental health status.

Keywords: nicotine dependence cigarette smoking nicotine replacement therapy positron emission tomography
a randomized controlled trial evaluating an online intervention in increasing seasonal influenza vaccination among community dwelling people aged ≥65 years

Conditions: Vaccination Refusal

Summary: a non-blinded two-arm parallel randomized controlled trial will be conducted. inclusion criteria are: 1) aged ≥65 years, 2) having hong kong id, 3) chinese speaking, 4) willing to be followed up by telephone, 5) having a smartphone, and 6) have not received siv for the incoming flu season. exclusion criteria include: 1) cognitive impairment, blindness or deafness, 2) not able to communicate with others effectively, and 3) with known contradictions of siv (allergic to previous siv, diagnosed/suspected egg allergy, with bleeding disorder or on warfarin). a total of 396 participants will be randomly assigned to either the intervention group (n=198) or the control group (n=198). intervention group will watch an online health promotion video tailored to their current stage of change related to siv uptake once every two weeks for four times (at week 0, 2, 4, and 6). participants in the control group will watch a same online video providing general advices related to siv at week 0, 2, 4, and 6. all participants will be followed up by telephone 3 and 6 months after the baseline survey.


Eligibility criteria:
inclusion criteria: * aged ≥65 years, * having hong kong id * chinese speaking * willing to be followed up by telephone * having a smartphone * have not received seasonal influenza vaccination for the incoming flu season exclusion criteria: * cognitive impairment, blindness or deafness, * not able to communicate with others effectively * with known contradictions of seasonal influenza vaccination listed by the centre for health protection (allergic to previous siv, diagnosed/suspected egg allergy, with bleeding disorder or on warfarin)
postoperative analgesia in patients undergoing percutaneous nephrolithotomy

Conditions: Postoperative Analgesia

Summary: percutaneous nephrolithotomy (pcnl) is a minimally invasive procedure to remove stones from the kidney by a small puncture wound through the skin. patients receiving lidocaine infusion had lower pain scores, reduced postoperative analgesic requirements and decreased intraoperative anesthetic requirements. erector spinae plane block (espb) seems to be effective when compared with no block or a placebo block.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) score i-ii.. * body mass index \< 35 kg/m2. exclusion criteria: * patient's refusal. * known coagulopathy. * known peripheral neuropathy or neurological deficits. * chronic pain disorders. * known allergy to study drugs
interest in the use of nasal high-flow oxygen therapy (optiflow™) in secondary transport of covid-19 positive patients

Conditions: COVID-19

Summary: since the beginning of covid-19 pandemic situation, several modes of ventilation have been tried to correct the hypoxaemia induced by sars-cov-2 virus. a few recent studies have concluded that high-flow nasal oxygen therapy (optiflow™) is beneficial in covid-19. all mainly conclude that the use of optiflow™ avoid intubations and decrease hospitalization duration in critical care services. at the emergency medical service 83 (samu 83), it has been decided to extend this ventilation mode during patient secondary transfers (transfer from an intensive care unit/other hospital unit/emergency department to another hospital's intensive care unit). the emergency medical service 83 has equipped its intensive-care ambulances with optiflow™ in order not to interrupt this ventilation mode during transport. the hypothesis is that patients with a severe respiratory form of covid-19 transported from one health facility to another by the emergency medical service 83 on high-flow nasal oxygen therapy has a reduced risk of intubation compared to the other modes of non-invasive ventilation (niv) and high concentration oxygen masks (hcm).

retrospective observational study in france including covid-19 infected patients taken care of by the emergency medical service 83 (samu 83) for a secondary transport between1st march 2020 and 31th december 2021.

Eligibility criteria:
inclusion criteria: * covid-positive patient diagnosed either by positive polymerase chain reaction (pcr) or radiological interpretation of chest ct * patient in respiratory distress treated during transport by high flow nasal oxygen or hcm (with a minimum flow of 15 l/min) or other niv modes * patient taken care of by the emergency medical service 83 (samu 83) for secondary transport (transfer from an intensive care unit/other hospital unit/emergency department to another hospital's intensive care unit) between1st march 2020 and 31th december 2021 exclusion criteria: * pre-transport intubation * patient opposition to participate in the study

Keywords: coronavirus disease 2019 (covid-19) severe acute respiratory syndrome coronavirus 2 (sars-cov-2) nasal high-flow oxygen therapy secondary transport by emergency medical service non-invasive ventilation
validation of a questionnaire for allodynia in migraine.

Conditions: Migraine

Summary: migraine is very frequent (15% of the general population). during attacks, many subjects with migraine have allodynia (pain induced by normally non-painful stimuli), photophobia (hypersensitivity to light), phonophobia (hypersensitivity to sound) or osmophobia (hypersensitivity to odours). the goal of the present study is to validate a new questionnaire made of 4 parts evaluating the presence of these 4 types of hypersensitivity, both during or between migraine attacks. it will allow to look for associations of these 4 symptoms and association of hypersensitivity with patients' or migraine's characteristics.

the prevalence of migraine is around 15% worldwide (gbd 2016, lancet neurol 2018). during attacks, and even between attacks, especially when migraine frequency is high, many subjects with migraine present with photophobia, phonophobia, osmophobia or allodynia. these symptoms are though to correspond to central sensitization and can be found in animal models of migraine (boyer et al., pain 2017; dallel et al., cephalalgia 2018). these 4 symptoms have been studied separately in previous studies but to date, there is no overall questionnaire evaluating these 4 sub-types of hypersensitivity. the investigators have constituted a questionnaire based on previous validated questionnaires that have been translated into french (lipton et al., 2008 for cutaneous allodynia; choi et al., 2009 for photophobia), a previous questionnaire validated in french (khalfa et al, 2002 for phonophobia) and created a few questions for each of the 4 symptoms, including osmophobia.

Eligibility criteria:
inclusion criteria: * subjects fulfilling 2018 international headache society criteria for migraine. * age \> 17 years. * written consent. exclusion criteria: * presence of neurological comorbidities that could lead to sensorial or sensitive abnormalities * presence of dermatological comorbidities that could lead to sensorial or sensitive abnormalities * presence of ent comorbidities that could lead to sensorial or sensitive abnormalities * significant cognitive dysfunction precluding proper completion of the self-administered questionnaire

Keywords: migraine allodynia photophobia phonophobia osmophobia central sensitization
lower extremity venous hemodynamics in obese patients without clinically significant venous disease

Conditions: Obesity; Peripheral Arterial Disease

Summary: this research project is investigating the relationship between body weight and function of the leg veins using a special non-invasive technique known as venous plethysmography.

disease of the veins include blood clots, varicose veins, leg swelling, and sores on the legs. venous disease is more common in overweight patients, but little is known as to why this is the case. this research project is investigating the relationship between body weight and function of the leg veins using a special non-invasive technique known as venous plethysmography. we hope to investigate the reason for the relationship between body weight and higher risk of vein problems. approximately 45 people will take part in this study. patients will be recruited from among three groups: normal weight people, overweight people, and obese people. resting ankle-brachial index will be measured in both lower extremities to exclude the presence of peripheral arterial disease. venous physiologic study using air plethysmography with positional maneuvers will be performed. parameters to be measured will be outflow time, passive draining and refill time, and exercise venous plethysmography. all studies will be performed with the phlebotest system (osborn medical). all study procedures will be done during one visit, and no further follow-up is required.

Eligibility criteria:
inclusion criteria: * age between 18-60 years old * bmi within one of three strata (normal: 18.5-24.9, obese: 30.0-39.9, morbidly obese: ≥ 40) exclusion criteria: * prior diagnosis of chronic venous insufficiency or venous stasis ulceration * prior diagnosis of lymphedema * significant lower extremity edema as determined by study investigators. lipidemia (in the absence of venous or lymphatic related edema) is acceptable. * varicose veins (subcutaneous dilated vein \> 3 mm in diameter measured in upright position). subjects with telangiectasias and/or mild reticular veins will be eligible (ceap c1) * patients who have been prescribed compression stockings by a health care provider at any time in the past, aside from prophylactic use during prior hospitalization to prevent vte * patients who have undergone any procedure for treatment of lower extremity varicose veins, including: sclerotherapy, venous ablation, phlebectomy, or a stripping procedure * history of dvt or svt * pregnancy * active malignancy * documented hypercoagulable state * body weight exceeds weight limit of the venous air plethysmograph chair equipment (approximately 375 lbs) * clinical diagnosis of lower extremity peripheral arterial disease or abnormal ankle-brachial index (abi) in either lower extremity * history of surgical intervention involving pelvis or lower extremities * pelvic or lower extremity radiation
mirena extension trial

Conditions: Contraception

Summary: the study is performed to assess if mirena is effective and safe as a birth control method beyond 5 years of use. further the menstrual blood loss (in women that had mirena inserted for the indication heavy menstrual bleeding \[hmb\]) and safety will be assessed.


Eligibility criteria:
inclusion criteria: * signed and dated informed consent * women, 18 to 35 years of age at the time of screening (visit 1) who are currently using mirena for contraception or for contraception and heavy menstrual bleeding. the duration of use of the current mirena has to be at least 4 years 6 months at the start of screening phase but not more than 5 years at visit 2 and the woman is willing to continue with its use and has a continuing need for contraception. * normal or clinically insignificant cervical smear not requiring further follow up exclusion criteria: * menopausal symptoms with follicle-stimulating hormone\>30 miu/ml * pregnancy or suspicion of pregnancy * uterine bleeding of unknown etiology * untreated acute cervicitis or vaginitis or other lower genital tract infections * increased susceptibility to pelvic infection * acute pelvic inflammatory disease (pid) or a history of pid unless successfully treated and which, in the investigator's opinion, has not negatively affected subject's fertility * congenital or acquired uterine anomaly if it distorts the uterine cavity * history of, diagnosed or suspected genital or other malignancy and untreated cervical dysplasia * any active acute liver disease or liver tumor (benign or malignant) * clinically significant endometrial polyp(s)

Keywords: birth control heavy menstrual bleeding
myasthenia gravis foundation of america global mg patient registry

Conditions: Myasthaenia Gravis; Myasthenia; Myasthenia Gravis Associated with Thymoma; Myasthenia Gravis Crisis; Myasthenia Gravis Exacerbations; Myasthenia Gravis Generalised; Myasthenia Gravis with Exacerbation (Disorder); Myasthenia Gravis, Adult Form; Myasthenia Gravis, Generalized; Myasthenia Gravis, Ocular; Myasthenia Gravis, Thymectomy; Myasthenia Gravis; Myasthenia Gravis, MuSK

Summary: the goal of this observational study is to learn about the experiences of people living with myasthenia gravis (mg) in the united states. the main questions it aims to answer are: * how and when are people with mg diagnosed? * what are the most common symptoms associated with mg? * what treatments are being used to treat mg? * what are the impacts of mg on activities of daily living, employment and quality of life? * what are the experiences with exacerbation, hospitalization and healthcare access for people with mg? participants will answer a survey to enroll in the study, and be invited to fill out an update survey twice a year.

this is a longitudinal, observational, patient reported registry.

Eligibility criteria:
inclusion criteria: * age over 18 * positive mg diagnosis exclusion criteria: * age under 18 * misdiagnosed with mg

Keywords: myasthenia patient registry mgfa myasthenia gravis foundation of america myasthenia gravis