Kornimate/medical-research-clean huggingface dataset:
blended cognitive behavioural therapy versus face-to-face cognitive behavioural therapy

Conditions: Adult Depression

Summary: depression is a prevalent and disabling disorder with great cost to the individual and the society. lately, the use of internet interventions as guided self-help has demonstrated remarkable results. however, certain shortcomings such as lack of personal adaptation has been identified. the presents study aims to investigate the potential of blending internet based interventions with face-to-face consultations using cognitive behavioural therapy (b-cbt). the main hypotheses are, that that b-cbt will be as clinically effective as tau, and that it will be acceptable to patients and clinicians. the study is designed as a two arm randomised non-inferiority trial comparing internet based b-cbt for depression to treatment as usual (tau) defined as 12 sessions of face-to-face cbt.


Eligibility criteria:
inclusion criteria: * being 18 years of age or older. * meet diagnostic and statistic manual of mental disorders 4th. edition (dsm-iv) diagnostic criteria for major depressive disorder as confirmed by the telephone administered mini international neuropsychiatric interview version 5.0 (mini)and a score of 5 or higher on the patient health questionnaire nine items (phq-9). exclusion criteria: * current high risk of suicide according to the mini interview section c. * co-morbid substance dependence, bipolar affective disorder, psychotic illness, obsessive compulsive disorder, as established at the mini interview. * currently receiving psychological treatment for depression in primary or specialised mental health care * being unable to comprehend the spoken and written language of danish. * not having access to a computer and fast internet connection (i.e. broadband or comparable)

Keywords: blended care cbt b-cbt depression
efficacy and safety of afq056 in reducing l-dopa induced dyskinesias in parkinson's disease patients, and safety in combination with l-dopa

Conditions: Parkinson's Disease

Summary: this study will evaluate the safety and efficacy of administration of afq056 in combination with l-dopa, in reducing the number of l-dopa related dyskinesias in parkinson's disease patients.


Eligibility criteria:
inclusion criteria: * patients with parkinson's disease * patients with l-dopa induced dyskinesia for at least 3 months * patients with l-dopa treatment for at least 3 years, stable for 1 month minimum exclusion criteria: * history of severe allergy to food or drugs * very low or high body weight. * prior surgery for parkinson's disease * smokers other protocol-defined inclusion/exclusion criteria may apply

Keywords: parkinson's, l-dopa, dyskinesia
management of patients on long term anticoagulation therapy undergoing a primary total hip of knee replacement

Conditions: Postoperative Complications

Summary: it is a multicenter, prospective, observational study of standard care. this study analyses the care of patients on long term effective anticoagulation therapy (adelc) during a primary hip or knee arthroplasty. the objectives of the study are to: 1. identify clinical practices set up for patient care 2. assess the type and the frequency of perioperative complications 3. look for factors, related to patients or treatments, associated with the occurrence of these complications. the main objective is to estimate the risks, adjusted and not, of postoperative complications associated to a long term anticoagulation by comparing patients under anticoagulation to a control group of patients having the same interventions but who are not under anticoagulation.


Eligibility criteria:
inclusion criteria: * adult ≥ 18 years * programmed for primary hip or knee arthroplasty. * effective dose of anticoagulant drugs intake for more than 1 month with the intention to resume it after the intervention for adelc cohort; no effective dose of anticoagulant drugs intake for the control cohort. exclusion criteria: * patient non opposition
nitrate supplementation during final examination stress

Conditions: Airway Disease

Summary: the purpose of the present study is to explore the effects of a dietary nitrate supplement on immunity, mood, cardiovascular activity, and lung function during and following final exam stress in both healthy and asthmatic individuals.

past research has demonstrated significant changes in immune response and airway inflammation during times of stress. specifically, significant decreases in the fraction of exhaled nitric oxide (feno) in both healthy and asthmatic undergraduate students have been found during times of final exam stress. additionally, research suggests that dietary supplementation of nitric oxide may have beneficial cardiovascular effects which may offset the physiological consequences of stress. this research study explores the effects of a dietary supplement on immunity, mood, cardiovascular and respiratory function during and following final exam stress. in this study, investigators monitor changes in respiratory infection incidence, airway nitric oxide, mood, blood pressure, and lung function in students with and without asthma during the time of final exams and a comparable time of low stress during the term. there are three assessments in the laboratory, as well as two additional brief questionnaires on separate days. during the final exam period, half of the participants are randomly assigned to the experimental group which is provided with a dietary supplement (beetroot juice drink) of which they are asked to take one dose every day in the morning for seven days. the three assessments periods include two during the week of final exams and one during a period of low stress scheduled up to two weeks to two months before that time. for the final exam period, the first of the two sessions takes place on the day before the second of these exams, and the second assessment takes place on a subsequent day after second exam. a follow-up assessment of cold symptoms takes place online 7 days after the final exam period.

Eligibility criteria:
inclusion criteria: * lung healthy or physician diagnosis of asthma * undergraduate student with at least 3 final examinations exclusion criteria: * current smoker * history of seizures * history of stroke * history of heart attack or heart disease * history of thyroid problems * history of head injury or neurological disorder * diabetes * any kind of lung disease (other than asthma) * corticosteroids within the past month * antibiotics within the past month

Keywords: dietary nitrate supplementation cold symptoms stress immunity exhaled nitric oxide lung function cardiovascular activity
ethanol-free clobetasol propionate foam 0.05% (olux-e foam) vs vehicle foam in the treatment of chronic hand dermatitis.

Conditions: Dermatitis, Chronic

Summary: the purpose of this study is to determine how clobetasol proprionate foam works against a placebo foam in the treatment of hand dermatitis.

topical corticosteroids have anti-inflammatory, immunosuppressive and antiproliferative properties. clobetasol propionate foam 0.05% (olux-e), a class 1 corticosteroid, is formulated in an ethanol free petrolatum base that provides the benefits of a super-potent corticosteroid combined with moisturizing ingredients in the treatment of corticosteroid responsive dermatoses. the current study is designed to show efficacy and safety in the treatment of moderate to severe chronic hand dermatitis.

Eligibility criteria:
inclusion criteria: * capable of understanding and willing to provide signed informed consent * male or female at least 12 years of age at time of consent and at time of first dose. * able to complete the study and to comply with study instructions. * moderate to severe hand dermatitis. * chronic hand dermatitis diagnosis must be at least 6 months exclusion criteria: * female who is pregnant, trying to become pregnant, or breast feeding. * currently diagnosed with allergic contact dermatitis. * participated in a previous study of the same study product. * had any major illness within 30 days before the screening/baseline visit. * considered immunocompromised. * has a clinically relevant history of or current evidence of abuse of alcohol or other drugs. * considered unable or unlikely to attend the necessary visits.
a study to evaluate safety of single doses of bms-986177 in patients with end stage renal disease (esrd) treated with hemodialysis

Conditions: Antithrombotic

Summary: to investigate safety of single doses of bms-986177 in patients with end stage renal disease treated with hemodialysis


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * subjects with esrd treated with hemodialysis 3 times a week for at least 3 months prior enrollment. * women of childbearing potential (wocbp) must have a negative serum or urine pregnancy test (minimum sensitivity 25 iu/l or equivalent units of hcg) within 24 hours prior to the start of study treatment. * women must not be breastfeeding * women of childbearing potential (wocbp) must agree to follow instructions for method(s) of contraception for the duration of treatment with study treatment(s) bms-986177 plus 5 half-lives of study treatment (2 days) plus 30 days (duration of ovulatory cycle) for a total of 32 days post-treatment completion * males who are sexually active with wocbp must agree to follow instructions for method(s) of contraception for the duration of treatment with study treatment(s) bms-986177 plus 5 half-lives of the study treatment plus 90 days (duration of sperm turnover) for a total of 92 days post-treatment completion. in addition, male participants must be willing to refrain from sperm donation during this time. exclusion criteria: * subjects receiving dialysis through central venous catheters * history of uncontrolled or unstable cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, hematopoietic, psychiatric and/or neurological disease in the past 3 months * current or recent (within 3 months of study drug administration) gastrointestinal disease or surgery, which by the judgment of the investigator, may increase a subject's risk of gastrointestinal bleeding or interfere with absorption of study drug (e.g., peptic or gastric ulcer disease, severe gastritis, history of gastrointestinal surgery). * any major surgery within 12 weeks of study drug administration * history of significant head injury within the last 2 years, including subjects with base of skull fractures other protocol defined inclusion/exclusion criteria could apply
neural therapy in notalgia paresthetica

Conditions: Notalgia Paresthetica

Summary: patients diagnosed with notalgia paresthetica and who received neural therapy within the last year were retrospectively screened. in the evaluations before treatment and at the 3rd month after treatment; numerical rating scale for pain, paindetect questionnaire for neuropathic pain, sf-12 for quality of life and 5-d itch scale for itch level were used.


Eligibility criteria:
inclusion criteria: * the presence of a hyperpigmented skin lesion consistent with np * minimum 6 months for duration of disease * 30-60 aged * application of neural therapy in a manner appropriate to the diagnosis exclusion criteria: * history of previous surgery or injection in the thoracic region * presence of another treatment in the same period * presence of any cardiac or pulmonary disease, malignancy, or advanced psychiatric disease

Keywords: back pain intralesional injection neuralgia pruritus
treatment outcomes of advanced neoplasia in ibd

Conditions: Inflammatory Bowel Diseases

Summary: in this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following an in cd and uc patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with an treatment choice.

in this retrospective multicenter cohort study, using palga (the dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. high metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.

Eligibility criteria:
inclusion criteria: * ibd (ulcerative colitis (uc), cd or ibd-unclassified (ibd-u)) * histological diagnosis of colorectal an * available treatment data exclusion criteria: * familial crc syndrome * an prior to ibd diagnosis
the effect of virtual reality on women undergoing hysterosalpingography

Conditions: Hysterosalpingography

Summary: the aim of this study is to determine the effect of virtual reality on perceived pain, anxiety, fear, physiological reactions and satisfaction in women during the hsg procedure. hypotheses h01; in the hsg procedure, there was no difference between the pain score of the virtual reality group and the pain score of the control group. h02; in the hsg procedure, there was no difference between the anxiety score of the virtual reality group and the anxiety score of the control group. h03; in the hsg procedure, there was no difference between the satisfaction score of the virtual reality group and the satisfaction score of the control group. h04; in the hsg procedure, there was no difference between the vital signs of the virtual reality group and the control group. h05; in the hsg procedure, there was no difference between the fear score of the virtual reality group and the fear score of the control group. the study will be carried out in two different groups. the practice will start with meeting the women who apply to the radiology clinic for an hsg. after the women are evaluated in terms of eligibility criteria for the research, the women who are eligible will be informed about the research and written informed consent will be obtained from the women who accept. the random distribution of women to the study groups will be carried out using the block randomization method. the following applications will be made to the groups. virtual reality group in addition to the routine procedure, virtual reality glasses will be applied to the women in the virtual reality group of the research. virtual reality glasses is a device that works on compatible smart mobile phones. after being taken to the gynecological table for the hsg procedure, the women included in the experimental group will be made to watch a video lasting an average of 10 minutes with virtual reality glasses until the procedure is completed. while watching the video, the relaxing music of the video will be played in the practice room with a bluetooth speaker. control group patients in the control group of the study will not be subjected to any treatment other than the routine procedure.


Eligibility criteria:
inclusion criteria: * primary infertility * agreeing to participate in the research and obtaining written permission, * no hearing or vision problems * the first time hsg procedure will be applied exclusion criteria: * didn't watch the whole video * those with motion-sensitive diseases such as vertigo, meniere * using any pharmacological pain-reducing method within 30 minutes * difficulty in the hsg process or completing the process with more than one attempt * use of antidepressants or sedatives * any history of allergy to radio-opaque dye
global postural reeducation versus neck stabilization training on text neck syndrome.

Conditions: Neck Syndrome

Summary: the study will be randomized control trial. the study will be conducted in iqbal mehmooda trust hospital. group a will be treated with global postural reeducation. group b will be treated with neck stabilization training. non probability consecutive sampling technique will be used. patient below 20-40 years, participants who use smart phones for 8 hours per day(guidelines), angle of forward head pasture above 15, screening picture tool. neurological defects, trauma, tumor, shoulder injury, cervical disc disease. reba questionnaire, ndi, goniometry, nprs will be used as a tool. the global postural reeducation will be applied on group a while neck stabilization training will be applied on group b. the aim of this study will be to compare the effects of of global postural reeducation and neck stabilization training on text neck syndrome.

''text neck syndrome'' describes the neck pain and looking down at the smart gadgets repeatedly and for prolonged duration that leads to damage of various structures. the cervical spine consists of bundles of nerves, bones, joints and muscles. if nerves are compressed then pain can radiate to shoulder, arm and hand. 79% of the population between the age of 18-44 use their cell phones almost all the time except only 2 hours of their walking time without the usage of their cell phones. the forward head posture/turtle neck posture causes strain on the muscles, ligaments and joints that leads to compression of nerves and it causes tingling and numbness in the hands. the usage of smart gadgets for prolonged duration has negative impact on our anxiety and depression. excessive use of smart phones leads to postural problems like forward neck posture, slouched posture or rounded shoulders.

Eligibility criteria:
inclusion criteria: * patient below 20-40 years * participants who use smart phones for 8 hours per day(guidelines) * angle of forward head posture above 15 * screening picture tool exclusion criteria: * neurological defects * trauma * tumor * shoulder injury * cervical disc disease

Keywords: text neck syndrome, reba questionnaire, turtle neck posture.
the effects of core stabilization exercises on balance, proprioception, and knee muscle strength in children with adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: scoliosis can be defined as a 3-dimensional deformity in which the lateral deviation and rotation of the vertebrae occur, as well as changes in the physiological curves of the spine. the gold standard criterion is that the cobb angle, which determines the lateral deviation of the spine in the frontal plane, is greater than 10°. postural control and balance occur as a result of the integration of many sensory information. it is thought that postural control and balance in adolescent idiopathic scoliosis (ais) patients are adversely affected by biomechanical changes in sensory input, central integration, weight transfer mechanism and the structure of the medulla spinalis. in addition to these, vestibular disorders and proprioceptive losses may have an effect on balance. decline in balance reduces the quality of life of individuals with ais. in addition, exercise has an important place in the treatment of individuals with ais. in order to get more efficiency from the exercises, it is necessary to improve the balance. the aim of this study is to evaluate the changes in balance, proprioception, and knee muscle strength of patients, to determine the place of balance exercises in the treatment of individuals with ais, and to investigate the effect of core stabilization exercises on balance and proprioception in patients with ais.


Eligibility criteria:
inclusion criteria: * diagnosed with ais between the ages of 10-18 * cobb angle is between 10-40 degrees * the child's and family's consent to participate in the study * the child does not receive any other treatment that will affect his scoliosis exclusion criteria: * surgical operation in the last 3 months * presence of an orthopedic, neurological, systemic disease that will prevent him from exercising * having mental, communicative and behavioral disorders that may cause problems understanding commands and questions or performing exercises * exercising 3 or more days a week.

Keywords: adolescent idiopathic scoliosis core stabilization exercises balance proprioception knee muscle strength
bioequivalence study of topiramate tablets 25mg under fed conditions

Conditions: Healthy

Summary: the objective of this study was to compare the single-dose relative bioavailability of ranbaxy and ortho-mcneil pharmaceutical (topamax®) 25 mg topiramate tablets following a 50 mg dose under fed conditions.

this was an open-label, randomized, single-dose, 2-way crossover, relative bioavailability study performed on 18 healthy adult male volunteers. a total of 17 subjects completed the clinical phase of the study. in each period, subjects were housed from the evening before dosing until after the 24-hour blood draw. subjects were to return for the 48-, 72-, 96- and 120-hour blood draws. both periods were separated by a washout period of 14 days.

Eligibility criteria:
inclusion criteria: 1. this study involved healthy adult male volunteers, 18-45 years of age, weighing at least 52 kg, who are within 15% of their ideal weights (table of "desirable weights of adults", metropolitan life insurance company, 1983). 2. only medically healthy subjects with clinically normal laboratory profiles were enrolled in the study. exclusion criteria: 1. history or presence of significant: * cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic or psychiatric disease. in addition, history or presence of: * hypersensitivity or idiosyncratic reaction to topiramate; * nephrolithiasis or gout; * alcoholism or drug abuse within the past year. 2. subjects who had been on an abnormal diet (for whatever reason) during the 28 days preceding the study. 3. subjects who had used any drugs or other substances known to be strong inhibitors of cyp (cytochrome p450) enzymes within 10 days of study start. 4. subjects who had used any drugs or other substances known to be strong inducers of cyp (cytochrome p450) enzymes within 28 days of study start. 5. subjects who, through completion of the study, would have donated in excess of: * 500 ml of blood in 14 days, or * 500- 750 ml of blood in 14 days (unless approved by the principal investigator), * 1000 ml. of blood in 90 days, * 1250 ml of blood in 120 days, * 1500 ml of blood in 180 days, * 2000 ml of blood in 270 days, * 2500 ml of blood in 1 year. 6. subjects who have participated in another clinical trial within 28 days of study start.

Keywords: topiramate fed study