Kornimate/medical-research-clean huggingface dataset:
misoprostol before hysteroscopy in infertile cases

Conditions: Infertility

Summary: the role of hysteroscopy in infertility investigation is to detect possible intrauterine changes that could interfere with implantation or growth or both of the conceptus, with the invention of miniature hysteroscope, it is possible to perform hysteroscopy in an office setting (outpatient hysteroscopy; oh), for diagnostic and certain therapeutic intervention. it is currently acknowledged as the 'gold standard' investigation of the intrauterine abnormalities. cervical priming prior to diagnostic hysteroscopy softens the cervix and lessens the force needed for dilation, thereby potentially reducing the probability of procedural complication such as uterine perforation, cervical laceration, failure to dilate, and creation of a false track that can occur during cervical entry. misoprostol is a prostaglandin el analogue, that can be administered either orally or vaginally, that can cause cervical ripening by inducing collagenolytic activity and synthesis of proteoglycans.


Eligibility criteria:
inclusion criteria: * female patients aged from 20 to 40 years old. * they are complaining with primary or secondary infertility. * they undergo investigations including husband semen analysis, hormonal assay, u/s, hystrosalpingography. exclusion criteria: * known sensitivity to misoprostol. * any systemic disease contraindicating the use of prostaglandins (cardiovascular disease, hypertension, renal failure, etc). * concomitant neurologic disease that could affect the correct evaluation of pain. * pregnancy. * any contraindication to hysteroscopy such as pelvic inflammatory disease (pid). * heavy uterine bleeding. * any uterine abnormality such as pinhole cervix that would obviate passage of a catheter through the cervix.
disappearance of graves' orbitopathy

Conditions: Thyroid Eye Disease

Summary: there is a general belief among physicians involved with graves' orbitopathy (go) that this syndrome is somehow "chronic", namely that the patient's eyes do not return the way they were before go appeared. the general impression that comes from the available studies is that the eyes of go patients do not return to normal even after a very long time since the disease appearance under the physician's point of view, although a discrete proportion of patients feel so. however, no studies are available in which the issue was examined with both objective criteria and self-assessment. the present study design was to investigated the disappearance of go, regardless to treatment, in all consecutive patients with a history of go of at least 10 years who came for a follow-up visit to our go clinic over a period of 5 years.


Eligibility criteria:
inclusion criteria: * all go patients with a go history of at least 10 years who came for a follow-up visit in our go clinic over a period of 5 consecutive years exclusion criteria: * none
institut paoli calmettes breast cancer database

Conditions: Breast Cancer Diagnosis

Summary: database of institut paoli-calmettes patients diagnosed with breast cancer


Eligibility criteria:
inclusion criteria: * patient with a diagnosis of breast cancer exclusion criteria: -
double-blind comparative study of syr-472

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to evaluate the efficacy and safety of treatment with syr-472 in diabetic patients.


Eligibility criteria:
inclusion criteria: 1. the participant is an outpatient. 2. the participant signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures. exclusion criteria: 1. the participant has any serious cardiac disease, serious cerebrovascular disorder, or any serious pancreatic or hematological disease.（e.g., subjects who require hospitalization or subjects who were hospitalized within 24 weeks prior to the commencement of the observation period) 2. the participant is considered ineligible for the study for any other reason by the investigator or subinvestigator.
serum levels of insulin- like growth factor and fertility

Conditions: Fertility

Summary: this study will try to determine whether serum levels of insulin like growth factor are higher in fertile women than infertile women.

this study will try to determine whether serum levels of insulin like growth factor are higher in fertile women than infertile women.the women will over 40 years old.

Eligibility criteria:
inclusion criteria: * 40-55 years old * healthy exclusion criteria: * pregnant women * breast feeding * menopause * vegetarian
cytosorb in patients with liver failure

Conditions: Liver Dysfunction

Summary: hemoadsorption has been demonstrated to improve liver functional tests in patients with liver failure. the present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with acute liver failure, on liver functional tests, severity scores and 30-days mortality. paraclinical results and severity scores were obtained before and after the three consecutive sessions.


Eligibility criteria:
inclusion criteria: * patients with acute liver failure or acute on chronic liver failure who require hemoadsorption in accordance with local guidelines exclusion criteria: * unsigned informed consent * duration of therapy under 12 hours * death before the three consecutive sessions
intensive strength training in children with cerebral palsy - effect on hand function

Conditions: Cerebral Palsy

Summary: the objective of this study is to gain more knowledge about the association between muscle weakness, spasticity and motor control in children with cerebral palsy, and its relationship to hand function.


Eligibility criteria:
inclusion criteria: * diagnosed spastic hemiplegic or diplegic cerebral palsy, reduced handfunction. * indication for treatment with botulinum toxin a * score 3 on house classification of upper-extremity functional use * score 3 or better on manual ability classification system exclusion criteria: * surgery within the last two years * treatment with botulinum toxin within the last six months
bedside sleep medicine

Conditions: Sleep Disorders; Sleep Apnea; Acute Myocardial Infarction; Acute Decompensated Heart Failure

Summary: the investigators aimed to evaluated the role of bedside sleep medicine in an cardiology intensive care unit. the patients will be submitted to a overnight polysomnography. those individuals with sleep apnea will be treated with cpap during the icu admission. also, the investigators will identify the factors that compromise the sleep and will act to minimize them to improve the sleep quality. after the interventions, the investigators will evaluate if there are reduced days of hospital admission, major cardiovascular events (infarction, reinfarction, heart failure and stroke) and overall mortality.

at the hospital discharge and after at 1, 3 and 12 months we will evaluate the occurrence of major cardiovascular events (infarction, reinfarction, heart failure and stroke) and overall mortality.

Eligibility criteria:
inclusion criteria: * acute myocardial infarction * acute decompensated heart failure * age \> 18 years-old * cardiology intensive care unit admission exclusion criteria: * intravenous sedation * invasive mechanical ventilation * hemodynamic instability * use of intravenous vasoactive drugs * acute respiratory failure

Keywords: sleep medicine sleep apnea acute myocardial infarction heart failure cpap
evaluation of biological response to sars-cov2 (covid-19) in patients with pre-existing neurological disease or newly neurological symptoms (bio-coco-neurosciences)

Conditions: Covid19; Neurologic Manifestations; Psychiatric Manifestations

Summary: patients with neurological or psychiatric symptoms or pre-existing disease will be sampled (blood for serum and dna or saliva for dna) at inclusion and at m6 (blood) and m12 (blood) depending on their pathology. sampling will be done either at hospital if patient is on site for routine care or at home if no consultation is scheduled at hospital.


Eligibility criteria:
1. age over 18 yo 2. patient having presented or presenting a covid-19 infection defined by a positive pcr or a typical chest scanner of covid-19 infection or a positive serology or a typical clinical picture in a pandemic period 3. and patient with: 1. a neurological or psychiatric manifestation de novo during or after the covid-19 infection and/or 2. either a chronic neurological or psychiatric pathology

Keywords: covid-19 neurological disease multiple sclerosis psychiatric disease biology, biocollection, biomarkers, dna, parkinson's disease
bonipar for acute and chronic musculoskeletal pain

Conditions: Chronic Pain; Musculoskeletal Pain

Summary: this study is a non-inferiority study comparing efficacy and onset of action between the herbal extracts topical solution, bonipar, and diclofenac sodium topical solution, diclofenac topical solution 1.5%.

this study is a non-inferiority study comparing efficacy and onset of action between the herbal extracts topical solution, bonipar, and diclofenac sodium topical solution, diclofenac topical solution 1.5% (approved by the fda as a topical analgesic). approximately 168 duke patients will be recruited from duke pain clinic, and selected duke primary care practices. individuals who report acute (less than 3 months duration) or chronic musculoskeletal pain of any intensity will be considered for enrollment into the study. after obtaining consent, eligible subjects will be will be randomized to receive bonipar or diclofenac topical solution 1.5%.

Eligibility criteria:
inclusionary criteria: * subject with acute and chronic localized musculoskeletal pain * ages 18 to 80 years * subjects of all races, gender or ethnic groups * female subjects of childbearing age must have a negative pregnancy test female subjects of childbearing age who are sexually active must agree to use appropriate contraceptive measures for the duration of the study. medically acceptable contraceptives include: (1) surgical sterilization (such as tubal ligation or hysterectomy), (2) approved hormonal contraceptives (such as birth control pills, patches, implants or injections), (3) barrier methods (such as a condom or diaphragm) used with a spermicide, or (4) an intrauterine device (iud). * willing to provide written informed consent * patients taking opioid or nsaid for their musculoskeletal pain may be included if pain is inadequately controlled exclusionary criteria: * patients meeting any of the following criteria will be excluded from the study: use within 3 days of any topical agents on the affected area * subject with active skin lesions or skin disease or with cutaneous manifestations of systemic illnesses * subject with history of uncontrolled diabetes (a1c of more than 9) * subject with history of uncontrolled hypertension (sbp \> 160 and dbp \> 95) * subject with active uncontrolled gerd (defined as more than 2 episodes per week) or history of peptic ulcer disease * subject with active cancer, spinal cord lesions or spine surgery * subject with allergies to diclofenac or to other non-steroid anti-inflammatory drugs (nsaid) * known allergies to any oils, methyl salicylate and/or camphor * subject is pregnant or lactating * subject with history of heart attack, stroke or blood clot, or recent coronary artery bypass graft surgery (cabg) (i.e., within the last six months) * subject with history of alcohol or drug abuse within 1 year * subject with history of severe cardiac, liver or kidney disease or any other medical condition that may interfere with the subject's ability to participate in the study as determined by the investigator
efficacy of ttmpb in adult cardiac surgery

Conditions: Acute Post Operative Pain

Summary: the goal of this clinical trial is to compare the efficacy of transversus thoracic muscle plane block (ttmpb) integrated in a modern multimodal analgesia protocol, following the eras® recommendations, in adult patients undergoing planned open heart surgery. the main study question is: does the addition of ttmpb to a standard analgesic protocol significantly improve analgesia following elective open heart surgery? the investigators will primarily compare postoperative opioid consumption and pain scores in patients who will be randomly allocated to one of two groups: the control group will receive standard analgesia per institutional intensive care unit protocol. the intervention group will receive the same standard of care plus a ttmp block (40ml of bupivacaine 0.375%, total dose of 150 mg). the investigators will also study the impact of group allocation on secondary outcomes, such as the rate of early mobilization.


Eligibility criteria:
inclusion criteria: * direct informed consent as documented by signature * major adult (≥ 18 years old) with body weight ≥ 50 kg. for the record, fifty kilograms is the minimal weight to ensure that participants remain safely away from maximal doses of la (3 mg/kg) * planned and primary cardiac surgery via a sternotomy approach * planned for ultra-fast-track procedure (i.e. postoperative extubation time of maximum two hours) exclusion criteria: * participation in another study with investigational drug within the 30 days preceding and during the present study * refusal and/or inability to understand or sign the informed consent * emergent cardiac surgery * previous cardiac surgery * known hypersensitivity or true allergy to bupivacaine and other amide-class la * chronic pain history * substance abuse history * inability to follow the procedures of the study (e.g. due to language problems, psychological / psychiatric disorders, dementia) * clinically significant concomitant diseases: severe cardiac dysfunction (i.e. lvef ≤ 35%); severe chronic obstructive pulmonary disease (i.e. fev \< 50%); severe hepatic disease. * severe obesity (bmi \> 35kg/m2)

Keywords: transversus thoracic muscle plane block adult cardiac surgery sternotomy
biologic glue for first degree perineal tears

Conditions: Grade 1 Perineal Tears

Summary: the use of octyl-2-cyanoacrylate adhesive glue is not inferior to traditional suturing for first degree perineal tears repair

this is a prospective randomized trial, comparing the use of octyl-2-cyanoacrylate adhesive glue to traditional suturing, for the repair of first degree perineal tears.

Eligibility criteria:
inclusion criteria: * women after instrumental or normal vaginal delivery with a diagnosis of first degree perineal tears exclusion criteria: * excessive bleeding, * chronic steroid treatment, * immunosuppressive treatment, * active infection, * allergy to dermabond or histoacryl

Keywords: adhesive glue, perineal tear, suture
efficacy and safety of tqb2618 injection combined with toripalimab injection in patients with advanced melanoma

Conditions: Melanoma

Summary: this study is an open, single-center, multi-cohort phase ib exploratory study, and 50 subjects are planned to be enrolled to observe the objective response rate of each subject. the safety evaluation of this study adopts common terminology criteria for adverse events version (ctcae) 5.0 to evaluate the adverse events of drugs. efficacy was evaluated using response evaluation criteria in solid tumors version (recist) 1.1 for immune-based therapeutics criteria.


Eligibility criteria:
inclusion criteria: * 1 age: 18-75 years old;ecog ps score: 0\~1;the expected survival is over 3 months * 2 patients with advanced melanoma diagnosed histologically and/or cytologically * 3 at least one measurable lesion was confirmed according to recist 1.1 criteria * 4 major organs are functioning normally * 5 female subjects of reproductive age should agree to use contraceptive methods (such as intrauterine devices, birth control pills, or condoms) during the study period and for 6 months after the end of the study;negative serum pregnancy/urine pregnancy test within 7 days prior to study enrollment and must be non-lactating subjects;male subjects should agree to use contraception during the study and for six months after the end of the study period exclusion criteria: * 1 present or present with other malignant tumors within 3 years prior to first use * 2 unalleviated toxicity above ctcae grade 1 due to any prior treatment * 3 major surgical treatment and significant traumatic injury were performed within 28 days prior to initial administration * 4 a wound or fracture that has not healed for a long time * 5 those who have a history of psychotropic drug abuse and can't get rid of it or have mental disorders * 6 subject with any severe and/or uncontrolled disease * 7 prior chemotherapy within 3 weeks prior to initial drug use, and prior radiotherapy or other antineoplastic drugs within 2 weeks prior to initial drug use * 8 those who have participated in and used other antitumor clinical trials within 4 weeks prior to the first drug use
subarachnoid administration of levobupivacaine for cesarean section

Conditions: Stillborn Caesarean Section

Summary: the purpose of the investigators study is to compare the clinical effects and side-effects of these three local anaesthetics as sole agents or with the supplementation with fentanyl for c-section, especially when administered in doses achieving approximately an ed 50.

intrathecal (i.t.) administration of isobaric bupivacaine, ropivacaine and levobupivacaine with or without addition of fentanyl for c-section do not exist to date . parturients scheduled for elective caesarean section will be allocated to receive double-blindly i.t. isobaric bupivacaine 10 mg, ropivacaine 15mg , levobupivacaine 10mg or the same local anaesthetics with 10 μg fentanyl respectively. sensory block (pin prick test) and motor block (bromage scale) profile, intraoperative and postoperative analgesia, haemodynamics and side effects will be assessed.

Eligibility criteria:
inclusion criteria: * parturients scheduled for elective c section * stillborn * normal cardiotocogram exclusion criteria: * bmi\>35kg/m2 * height \ 185cm * age (\ 40) * asa \> ii * multiple gestation * pregnancy complications (eclampsia, gdp, placenta previa, \>2 previous c section) * contraindication to spinal anaesthesia * failure to educate the patient, language barrier * patient preferred ga
migo tracker remote monitoring of home exercise after stroke

Conditions: Subacute Stroke

Summary: this project will determine the safety and effectiveness of a migo tracker rtm program in a randomized controlled trial with individuals with subacute stroke (n=50). participants will be randomly assigned to either the migo tracker rtm program (intervention group) or prescription of home exercises with no monitoring (usual care/control group). all participants will still receive usual post-stroke care, including outpatient rehabilitation. the main question this study aims to answer is: does a migo tracker rtm program lead to significantly greater motor recovery at three-months post stroke than the usual care group. if successful, migo tracker will lead to increased home exercise adherence and improved health outcomes for thousands of individuals following stroke.


Eligibility criteria:
inclusion criteria: * experienced one or more strokes less than one month (30 days) prior * upper extremity fugl-meyer score \> 5 and \<= 55 out of 66 * absence of moderate to severe pain (\<= 4 on the 10 point visual-analog pain scale) exclusion criteria: * age \<18 years old * unable to follow 2-step commands * other neurological diagnosis (e.g. parkinson's disease) * other severe concurrent medical conditions that may prevent the participants from completing the 3-month study

Keywords: remote therapeutic monitoring stroke home exercise therapy migo tracker
a study of the rate of progression of glaucoma during a follow-up period of two years

Conditions: Glaucoma, Open-Angle

Summary: this is an epidemiological, non-interventional, prospective study to collect data on glaucoma progression in a routine setting. patients may receive treatment at the discretion of their physician per local standard of care.


Eligibility criteria:
inclusion criteria: * glaucoma in one or both eyes exclusion criteria: * participation in a glaucoma therapeutic clinical trial
efficacy of intravenous ibuprofen and paracetamol on postoperative pain and morphine consumption in lumbar disc surgery

Conditions: Postoperative Pain Management

Summary: primary aim of this prospective, randomized, double-blind, placebo-controlled clinical trial is to compare the analgesic effects of iv ibuprofen and paracetamol on postoperative pain, and secondary aim is the effects on morphine consumption and side effects of morphine in patients who underwent lumbar disc surgery with a single level laminectomy or discectomy.

all surgical procedures are associated with acute pain and inflammation, with varying degrees of severity for patients, causing significant stress and discomfort. effective postoperative pain management in lumbar disc surgery may reduce complications and improve postoperative care. for postoperative pain, multimodal analgesic techniques are used to provide synergistic effects through different nociceptive mechanisms. various analgesics are used for pain. opioids, commonly used for postoperative pain, are the most popular drug group. side effects such as sedation, respiratory depression, nausea-vomiting, pruritus and urinary retention that develop secondary to opioids may also be reduced by the combination of supplemental analgesics. adjuvant agents, including nonsteroidal anti-inflammatory drugs (nsaid), may be used in combination with opioids. these drugs not only reduce pain but also control the underlying inflammatory process. in addition, combining nsaids and opioids can help to reduce the side effects by minimizing administration of total opioid consumption. intravenous (iv) ibuprofen is the first and only iv nsaid approved in the united states for both pain and fever control in adults. it has been reported in multicenter studies that iv ibuprofen is safe and effective in postoperative pain management for abdominal hysterectomy and orthopedic surgeries. iv paracetamol is an analgesic and antipyretic agent used as a first step drug for pain and fever control in adults and children. it has been clearly shown that iv paracetamol, with analgesic efficacy and good safety profile, reduces analgesic requirements for pain management. it provides better analgesic efficacy and reduces opioid consumption when used in combination with opioids.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists scores 1-3 * 18-85 years exclusion criteria: * american society of anesthesiologists scores iv, * under the age of 18, * over the age of 85, * peptic ulcer disease, * hepatic and renal dysfunction, * severe cardiovascular and pulmonary disease, * allergic history to propofol, fentanyl, rocuronium, paracetamol, ibuprofen and morphine, * emergency surgery, * refused informed consent form

Keywords: postoperative pain intravenous ibuprofen intravenous paracetamol lumbar disc surgery