Kornimate/medical-research-clean huggingface dataset:
biomarkers in predicting response to treatment in patients who have undergone surgery for pancreatic cancer

Conditions: Pancreatic Cancer

Summary: rationale: studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. it may also help doctors predict how patients will respond to treatment. purpose: this laboratory study is looking at biomarkers in predicting response to treatment in patients who have undergone surgery for pancreatic cancer.

objectives: * to determine if a method of extracting and identifying biomarkers (i.e., secreted cytokines and growth factors) from tissues of the quantity obtained from typical biopsy can now be applied in the setting of pancreatic cancer * to correlate pre-treatment biomarkers with recurrence, overall survival, and tumor response to radiotherapy and chemotherapy in patients with pancreatic cancer. outline: tumor tissue specimens are obtained from the vanderbilt ingram cancer center human tissue acquisition core and analyzed for biomarkers (e.g., integrity of dna repair pathways as analyzed by rad51 and phosphorylated dna-pk foci formation). the biomarkers are correlated with clinical outcomes (recurrence, overall survival, and tumor response to treatment). patients are followed for recurrence, relapse, and death from disease.

Eligibility criteria:
inclusion criteria * diagnosis of pancreatic cancer * excess tissue collected at the time of routine surgery for pancreatic cancer must be available for analysis exclusion criteria * none known

Keywords: pancreatic cancer
impact of folates in the care of the male infertility

Conditions: Male Infertility

Summary: unexplained male infertility is increasing, and, nowadays, the investigators only can propose palliative treatment, as in vitro fertilization (ivf). the folate metabolism is a key for the maintenance of genome integrity. a dysfunction in this pathway can be responsible of spermatogenesis defects, and further, of infertility. few assays have shown that folate treatment can improve sperm parameters and fertility, till 30% in some of theses studies. the purpose of the investigators study is to demonstrate the impact of folates treatment on improvement of sperm parameters and on the rate of success of in vitro fertilization procedures.

the folate impact in the treatment of male infertility will be reviewed by this large multicentric randomized controlled double-blind study comparing 2 parallel groups of 184 patients. in each group: folic acid 15mg/day versus placebo, orally for at least 3 months (duration of a cycle of spermatogenesis). this assay will evaluate the effectiveness of treatment with folic acid compared to its placebo in infertile men with the outcome of ivf+/-icsi techniques (pregnancy rate). it will also assess the impact of folate therapy on sperm parameters, and further, the impact on abnormal sperm dna methylation profiles.

Eligibility criteria:
inclusion criteria: * couple whose man is from 18 to 60 years old * couple whose man presents an infertility indicating a care in vitro fertilization with or without intracytoplasmic sperm injection (ivf +/- icsi) * couple whose spouse is from 18 to 38 years old * couple whose spouse do not present particular factors of infertility * couple taken care in ivf +/- icsi * couple with social insurance * 2 members of the couple having signed the consent exclusion criteria: * etiology of not genetic known male infertility : infertility of neoplastic origine, infertility of definitive obstructive origin * presence of a factor of feminine infertility : a definitive infertility tubal, turned out ovarian incapacity (fsh \> 9 and/or cfa \<= 8) * male infertility requiring the appeal to some sperm testicular or in some frozen sperm- men or women attend of hiv or hepatitis b or c * epileptic men * men under anti-folic treatment * men presenting a big sensibility to the folic acid or to one of the constituents of the drug * couple of which one of the partners refuses to participate in the study

Keywords: male infertility folic acid in vitro fertilization sperm parameters mthfr genotype
study to evaluate the effectiveness of the device in detection of abnormal findings on chest x-ray

Conditions: Pulmonary Disease

Summary: this study aims to evaluate the effectiveness of the investigational device (lunit insight cxr) in the detection of chest abnormalities

in the study, the standalone performance of lunit insight cxr was primarily assessed by comparing the analysis results from the investigational device and reference standards in the detection of 10 abnormal radiologic findings - atelectasis, calcification, cardiomegaly, consolidation, fibrosis, mediastinal widening, nodule/mass, pleural effusion, pneumoperitoneum, and pneumothorax.

Eligibility criteria:
inclusion criteria: * chest radiographs of aged 14 years or older * conventional pa or ap chest radiographs * chest radiographs with confirmed radiology reports exclusion criteria: * chest radiographs taken in postures other than pa and ap * chest radiographs from dual-energy radiography * invert-grayscale chest radiographs
therapeutic resistance and clonal evolution assessed with liquid biopsy in icis treated nsclc patients

Conditions: Lung Neoplasms; Lung Cancer, Nonsmall Cell; Adenocarcinoma of Lung; Squamous Cell Lung Cancer

Summary: to evaluate the predictive value of ctdna in response, relapse for patients treated with immune checkpoint inhibitors or targeted therapy for alk, ros1, met ex14 skipping.

in the study, 250 advanced nsclc patients will be recruited. all the patients will receive tissue biopsy and circultating tumor dna (ctdna) liquid biopsy before entry the study. patients who have no actionable mutations in egfr or alk and receive icis treatment and patients who carry actionable ros1 fusion, alk fusion or met exon 14 skipping mutation and receive tki treatment according to guidelines will take liquid biopsy assay to monitor the mutation status. the study will be ended when over 70% of the patients had a progressive disease (pd) in their targeted lesion.

Eligibility criteria:
inclusion criteria: * provision of informed consent * newly diagnosed and histological or cytological confirmed stage iiib-iv lung adenocarcinoma or squamous cell carcinoma patients according to the ajcc staging system. the stage iv lung cancer and brain metastasis can be diagnosed by imaging and enhanced ct respectively * no egfr mutation in tissue and ctdna * received immune checkpoint inhibitors as the first line therapy * ecog performance status 0-2 with expected more than 6 months of survival time * willingness to comply with required protocols and give permission to use the data for clinical research and products development exclusion criteria: * patients have other primary cancers * patients have symptomatic brain metastasis, complications that are associated with brain metastasis or cognitive disorders * patients failed in either plasma or tissue sample qc

Keywords: next generation sequencing (ngs) liquid biopsy immune checkpoint inhibitor whole transcriptome sequencing
the practice of providing palliative care in the situation of the covid-19 pandemic

Conditions: COVID-19 Pandemic; End-of-life

Summary: the practice of providing palliative care in the situation of the covid-19 pandemic in the perspective of physicians and nurses - survey study (people-c19 study)

pandemic of coronavirus sars-cov-2 (severe acute respiratory syndrome coronavirus 2) causing the disease covid-19 (coronavirus disease 2019) overwhelmed healthcare and brought new challenges and stressful situations. in a short time, intensive care units (icu) capacities were filled in many countries and regions. due to the need for an excessive number of patients requiring intensive care, physicians and nurses who do not routinely provide care to critically ill patients or do not have the appropriate training (non-icu clinician) were involved in the care of covid-19 patients. in this context, icu directly dedicated to caring for patients with covid-19 ards (acute respiratory distress syndrome) was also opened. non-icu clinicians were more or less involved together with the standard icu staff in palliative care, including end-of-life decision (eold) making, even in a situation of limited, scarce resources (equipment or personnel). new workplace and scope of work, which did not correspond to the standard activity or education, most likely led to an increased stress load. eold can also be one of the factors leading to increased stress levels. the project aims to describe the practice of palliative care for patients with covid-19 in a situation of pandemic covid-19 and to identify factors leading to possible moral distress related to eold.

Eligibility criteria:
inclusion criteria: * healthcare providers (physicians/nurses) * involvement in care for patients with covid-19 admitted at intensive care unit exclusion criteria: * non-icu staff * not involved in care for patients with covid-19

Keywords: covid-19 palliative care end-of-life
bosentan in systemic sclerosis

Conditions: Systemic Sclerosis; Digital Ulcers

Summary: the effect of bosentan on digital ulcers (du) was studied in two randomized placebo-controlled trials (rapids-1 and rapids-2). a limitation of these studies was the heterogeneous study population. more importantly, there were no endpoints that assessed changes in vasculopathy and / or perfusion. laser doppler imaging has been shown to effectively demonstrate blood flow restrictions in the hands of patients with systemic sclerosis (ssc). the relation between blood flow restriction in the hands measured by laser doppler imaging and the extent of du disease has not been studied. the current study will attempt to demonstrate this relation. in addition, the impact of bosentan on the blood flow in the hands, in a defined cohort of ssc-du patients with a history of du within the past 2 years and a clinically relevant reduction of blood flow in the hands, will be assessed.


Eligibility criteria:
inclusion criteria: * male and female subjects \> 18 years diagnosed with ssc; * reduction of blood flow measured by laser doppler imaging, of at least 50%, distally to the proximal interphalangeal joint, compared to the healthy volunteers; * women of childbearing potential must have a negative pregnancy test and use a reliable form of contraception; * a history of 1 or more dus within 2 years prior to inclusion; * no use of bosentan in the past; * subjects willing and able to sign informed consent. exclusion criteria: * parenteral prostanoid treatment for du \< 3 months ago; * chronic treatment with pde-5 inhibitor or era; * history of bosentan use * irreversible significant limitation of the hand function, e.g. amputation of more than one finger; * other types of system- or connective tissue diseases; * significant peripheral (macro-) vascular disease due to e.g. diabetes, hyperlipidemia, uncontrolled systemic hypertension, coagulopathy; * any serious medical co morbidity (eg, active malignancy) such that the subjects life expectancy is \< 12 months; * known ast and/or alt elevations higher than 3 times upper limit normal (uln); * moderate to severe liver function disorder; * pregnancy or breastfeeding; * treatment with glibenclamide, fluconazole, cyclosporin a, tacrolimus or other calcineurin inhibitors; * hypersensitivity for bosentan or one of its components; * subjects not able to follow the protocol.
investigation of the relationship between pelvic floor awareness and urinary incontinence

Conditions: Pelvic Floor; Urinary Incontinence; Young Athletes

Summary: there is no study in the literature examining the knowledge level and urinary symptoms of active athletes about the pelvic floor. the aim of this study is to determine the relationship between ptc awareness and incontinence in young athletes who engage in long-term and high-intensity activities that increase the risk of sui.


Eligibility criteria:
inclusion criteria: 18-25 years old young athletes exclusion criteria: having a neurological disorders

Keywords: pelvic floor awareness knowledge urinary incontinence athletes
telehealth parent coaching to improve activity participation for young children with asd and spd

Conditions: Sensory Processing Disorder; Autism Spectrum Disorder

Summary: this clinical trial aims to develop parent-child interaction strategy coaching and sensory processing strategy coaching via telehealth and examine the feasibility and efficacy of the interventions in young children with autism spectrum disorder who have sensory processing disorder. in the first experiment, the investigators will apply a single-subject research design and one-group pre-post test design to explore the feasibility of the coaching interventions. in the second experiment, rct design will be used to examine the effectiveness of parent coaching. sixty-five children with asd and their parents will be randomly assigned to the intervention or control group. the intervention group will receive weekly parent-child interaction and sensory processing strategy coaching for 12 weeks. the control group will be provided with weekly self-learning materials and group discussion session for 12 weeks. additionally, the follow-up test will be administered three months after the intervention.


Eligibility criteria:
inclusion criteria: * the child is 3 to 5 years old * the child is diagnosed with asd by a child psychiatrist or specialist in psychology based on the dsm-5's diagnostic criteria * the child's score falls within the category of dysfunction in one or more sensory processing functions in the sensory profile (3-10 years old version) exclusion criteria: * children diagnosed with major neuromuscular dysfunction or other disease diagnoses, such as epilepsy or other genetic diseases * children whose parents could not speak hokkenese or chinese and read in chinese * individuals who have participated in the first year of this study

Keywords: sensory processing disorder parent-mediated intervention autism spectrum disorder parent coaching via telehealth
carotid and vertebral magnetic resonance angiography (mra) study comparing dotarem and time of flight (tof)

Conditions: Cerebral Arterial Diseases

Summary: the study will evaluate the efficacy and safety of dotarem enhanced mra in patients suffering from carotid or vertebral arterial disease.

each subject will undergo a time of flight (tof) magnetic resonance angiography (mra) followed by a dotarem enhanced mra.

Eligibility criteria:
inclusion criteria: * male or female, aged more than 18 years * strongly suspected of having carotid or vertebral arterial disease * scheduled (or to be scheduled) to undergo computed tomography angiography (cta) examination exclusion criteria: * known grade iv or v chronic kidney disease (gfr\<30 ml/min/1.73m²) * contraindication to mri * acute renal dysfunction within the 6 months preceding dotarem®-enhanced mra examination

Keywords: carotid or vertebral artery disease contrast agent mra
a study of changes in heart function and blood flow in people receiving anesthesia

Conditions: Anesthesia

Summary: the purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. the researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.


Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years of age requiring general anesthesia for surgery * intubation required for anesthetic management / surgery * anticipated prep time before incision of 20 minutes * baseline map \>70mmhg exclusion criteria: * history of coronary artery disease * history of cardiac disease (e.g., htn, arrythmias, valvular and structural abnormalities) * history of peripheral artery occlusive disease * beta-blocker use * anti-hypertensive medication use * patients with epidural, spinal, paravertebral, serratus blocks preoperatively * patients requiring rapid sequence induction (where intubation occurs concurrently with induction) * emergency surgery

Keywords: changes in heart function changes in blood flow echocardiography 23-079
surfactant administration during spontaneous breathing

Conditions: Pneumothorax; Pulmonary Interstitial Emphysema; Bronchopulmonary Dysplasia

Summary: spontaneous breathing supported by nasal continuous positive airway pressure (ncpap) is thought to have some advantages compared with mechanical ventilation in premature infants. in addition, early surfactant administration has been shown to be superior to delayed use. the aim of this pilot study was to describe the feasibility of take care (early administration of surfactant in spontaneous breathing) procedure and compare its short-term and long-term results with insure procedure.

in take care procedure all premature infants who suffered from respiratory distress syndrome (rds) received 100 mg/kg of porcine surfactant preparation via an intratracheal catheter during spontaneous breathing. in the control group infants treated with insure procedure were intubated and ventilated to receive surfactant and placed on ncpap rapidly after surfactant administration. the procedures were compared for short-term efficacy and possible complications.

Eligibility criteria:
inclusion criteria: * all infants who presented with clinical anl laboratory signs of rds exclusion criteria: * infants who required intubation or ppv right after birth

Keywords: surfactant intubation spontaneous breathing bronchopulmonary dysplasia
the effective concentration of lidocaine with fentanyl in lumbar epidural anesthesia for transurethral resection of prostate(turp) in elderly patients

Conditions: BPH( Benign Prostate Hyperplasia); TURP(Transurethral Resection of Prostate)

Summary: epidural lidocaine is widely used in anesthesia for urologic or lower abdominal surgery because of its rapid onset. but the epidural anesthesia using high concentration of lidocaine may cause excessive motor block and unwanted side effects such as nausea, vomiting and hypotension. this is a study to determine the effective concentration of lidocaine with fentanyl in lumbar epidural anesthesia for transurethral resection of prostate in elderly patients.


Eligibility criteria:
inclusion criteria: * asa 1 -3, patients scheduled for turp( transurethral resection of prostate) were included exclusion criteria: * patients with any contraindication to epidural anesthesia were excluded. * cognitive impairment * coagulopathy * allergy to lidocaine * infection at the puncture site
study of vanadium supplement in patients with impaired glucose tolerance

Conditions: Prediabetic State

Summary: the purpose of this study was to evaluate if the vanadium can improve the insulin sensitivity in patients with impaired glucose tolerance. secondary purpose of this study was to assess changes on metabolic profile, weight and blood pressure.


Eligibility criteria:
inclusion criteria: * diagnosis of impaired glucose tolerance * body mass index from 25 to 35 kg/m2 * history of type 2 diabetes mellitus in the first branch exclusion criteria: * taking medication with known effects on carbohydrate or insulin metabolism * thyroid diseases * hepatic diseases

Keywords: vanadium insulin sensitivity impaired glucose tolerance triglycerides
evaluation of questionnaires of tumor patients with and without additive homeopathic therapy

Conditions: Tumor

Summary: tumor patients receiving conventional tumor therapies are included into this study. the patients are randomized into two groups receiving either additive homeopathic therapy or not. two questionnaires referring to subjective feeling and life quality are filled out by the patients with each visit to the outpatients department. one of them is the qlqc30 questionnaire of the eortc. the results of the questionnaires of the two groups are compared.

quality of life is an important issue for cancer patients, especially during the periods of chemotherapy and radiation. preliminary results have revealed positive effects of add-on homeopathy on quality of life as well as subjective well-being. patients are receiving classical homeopathy with administration of either globules and/or dilutions. with each appointment, patients complete two questionnaires.

Eligibility criteria:
inclusion criteria: tumor patients between 18 and 100 years old exclusion criteria: patients younger than 18 years, patients having completed less than 3 questionnaires.

Keywords: life quality questionnaire tumor patients
machine learning-based risk stratification for fistula formation after perianal abscess drainage

Conditions: Perianal Abscess; Anal Fistula

Summary: this prospective cohort study investigates the influence of provider experience and drainage location on fistula formation within 6 months following perianal abscess drainage. additionally, the study explores the role of artificial intelligence (ai)-based interpretation of magnetic resonance (mr) images in early identification of fistula development.

perianal abscess drainage is a common surgical procedure. however, subsequent fistula formation remains a significant complication. this study aims to determine whether the procedure setting (operating room, emergency department, or outpatient clinic) and the experience level of the performing clinician affect fistula development rates. furthermore, the study evaluates the use of ai-assisted analysis of selected mr images to identify early signs of fistula formation. selected image slices will be labeled based on radiological reports, and a machine learning model will be trained to predict fistula risk. the study will also compare ai-generated interpretations with expert radiologist assessments to validate performance. the ultimate goal is to create a risk stratification tool to support clinical decision-making in surgical management of perianal abscesses.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * first-time perianal abscess * surgical drainage performed exclusion criteria: * existing anal fistula history * crohn's disease * immunosuppressive treatment * incomplete 6-month follow-up

Keywords: artificial intelligence mr imaging colorectal surgery surgical outcomes drainage fistula prediction