n-acetyl-l-leucine for ataxia-telangiectasia (a-t)

Conditions: Ataxia Telangiectasia; Louis Bar Syndrome

Summary: this is a multinational, multicenter, open-label, rater-blinded prospective phase ii study which will assess the safety and efficacy of n-acetyl-l-leucine (ib1001) for the treatment of ataxia-telangiectasia (a-t). there are two phases to this study: the parent study, and the extension phase. the parent study evaluates the safety and efficacy of n-acetyl-l-leucine (ib1001) for the symptomatic treatment of a-t. the extension phase evaluates the long-term safety and efficacy of ib1001 for the neuroprotective, disease-modifying treatment of a-t.

the primary purpose of the study is to evaluate the safety and efficacy of n-acetyl-l-leucine (ib1001) in the treatment of a-t investigating the efficacy in terms of improving symptoms, functioning, and quality of life against the defined endpoints in patients with a-t. patients will be assessed during three study phases: a baseline period, a 6-week treatment period, and a 6-week post-treatment washout period. if within 6 weeks prior to the initial screening visit, a patient has received any of the prohibited medications defined in the eligibility criteria (irrespective of the preceding treatment duration) a wash-out study-run in of 6 weeks is required prior to the first baseline assessment. all patients will receive the study drug during this study. for each individual patient, the study lasts for approximately 3.5 - 4 months during which there are 6 study visits to the study site. this extension phase allows patients who have completed the parent study to, at the discretion of the principal investigator (pi), continue treatment with n-acetyl-l-leucine (ib1001). patients will receive treatment with ib1001 for two one-year treatment periods, separated by a 6-week washout. all patients will receive the study drug during the treatment period. for each individual patient, the extension phase lasts for approximately 25.5 months, during which there are 6 visits to the study site.

Eligibility criteria:
inclusion criteria individuals who meet all of the following criteria are eligible to participate in the study: 1. written informed consent signed by the patient and/or their legal representative/ parent 2. male or female aged ≥6 years with a confirmed diagnosis of a-t at the time of signing informed consent. 3. females of childbearing potential, defined as a premenopausal female capable of becoming pregnant, will be included if they are either sexually inactive (sexually abstinent for 14 days prior to the first dose continuing through 28 days after the last dose) or using one of the following highly effective contraceptives (i.e. results in \<1% failure rate when used consistently and correctly) 14 days prior to the first dose continuing through 28 days after the last dose: 1. intrauterine device (iud); 2. surgical sterilization of the partner (vasectomy for 6 months minimum); 3. combined (estrogen or progestogen containing) hormonal contraception associated with the inhibition of ovulation (either oral, intravaginal, or transdermal); 4. progestogen-only hormonal contraception associated with the inhibition of ovulation (either oral, injectable, or implantable); 5. intrauterine hormone-releasing system (ius); 6. bilateral tubal occlusion. 4. females of non-childbearing potential must have undergone one of the following sterilization procedures at least 6 months prior to the first dose: 1. hysteroscopic sterilization; 2. bilateral tubal ligation or bilateral salpingectomy; 3. hysterectomy; 4. bilateral oophorectomy; or be postmenopausal with amenorrhea for at least 1 year prior to the first dose and follicle stimulating hormone (fsh) serum levels consistent with postmenopausal status. fsh analysis for postmenopausal women will be done at screening. fsh levels should be in the postmenopausal range as determined by the central laboratory. 5. non-vasectomized male patient agrees to use a condom with spermicide or abstain from sexual intercourse during the study until 90 days beyond the last dose of study medication and the female partner agrees to comply with inclusion criteria 3 or 4. for a vasectomized male who has had his vasectomy 6 months or more prior to study start, it is required that they use a condom during sexual intercourse. a male who has been vasectomized less than 6 months prior to study start must follow the same restrictions as a non-vasectomized male. 6. if male, the patient agrees not to donate sperm from the first dose until 90 days after dosing. 7. patients must fall within: a) a sara score of 5 ≤ x ≤ 33 points (out of 40) and i. within the 2-7 range (out of 0-8 range) of the gait subtest of the sara scale or ii. be able to perform the 9 hole peg test with dominant hand (9hpt-d) (scafi subtest) in 20 ≤ x ≤150 seconds. 8. weight ≥15 kg at screening. 9. patients are willing to disclose their existing medications/therapies for (the symptoms) of a-t, including those on the prohibited medication list. non-prohibited medications/therapies (e.g. concomitant speech therapy, and physiotherapy) are permitted provided: 1. the investigator does not believe the medication/therapy will interfere with the study protocol/results 2. patients have been on a stable dose/duration and type of therapy for at least 6 weeks before visit 1 (baseline 1) 3. patients are willing to maintain a stable dose/do not change their therapy throughout the duration of the study. 10. an understanding of the implications of study participation, provided in the written patient information and informed consent by patients or their legal representative/parent, and demonstrates a willingness to comply with instructions and attend required study visits (for children this criterion will also be assessed in parents or appointed guardians). exclusion criteria individuals who meet any of the following criteria are not eligible to participate in the study: 1. asymptomatic patients 2. patient has clinical features of a-t, but a completely negative result on a previous genetic test for a-t. 3. patients who have any of the following: 1. chronic diarrhea; 2. unexplained visual loss; 3. malignancies; 4. insulin-dependent diabetes mellitus. 5. known history of hypersensitivity to the n-acetyl-leucine (dl-, l-, d-) or derivatives. 6. history of known hypersensitivity to excipients of ora-blend® (namely sucrose, sorbitol, cellulose, carboxymethylcellulose, xanthan gum, carrageenan, dimethicone, methylparaben, and potassium sorbate). 4. simultaneous participation in another clinical study or participation in any clinical study involving administration of an investigational medicinal product (imp; 'study drug') within 6 weeks prior to visit 1. 5. patients with a physical or psychiatric condition which, at the investigator's discretion, may put the patient at risk, may confound the study results, or may interfere with the patient's participation in the clinical study. 6. known clinically-significant (at the discretion of the investigator) laboratories in hematology, coagulation, clinical chemistry, or urinalysis, including, but not limited to: 1. aspartate aminotransferase (ast) or alanine aminotransferase (alt) \>5x upper limit of normal (uln); 2. total bilirubin \>1.5x uln, unless gilbert's syndrome is present in which case total bilirubin \>2x uln. 7. known or persistent use, misuse, or dependency of medication, drugs, or alcohol. 8. current or planned pregnancy or women who are breastfeeding. 9. patients with severe vision or hearing impairment (that is not corrected by glasses or hearing aids) that, at the investigator's discretion, interferes with their ability to perform study assessments. 10. patients who have been diagnosed with arthritis or other musculoskeletal disorders affecting joints, muscles, ligaments, and/or nerves that by themselves affects patient's mobility and, at the investigator's discretion, interferes with their ability to perform study assessments. 11. patients unwilling and/or not able to undergo a 6-week washout period from any of the following prohibited medication prior to visit 1 (baseline 1) and remain without prohibited medication through visit 6. 1. aminopyridines (including sustained-release form); 2. n-acetyl-dl-leucine (e.g. tanganil®); 3. n-acetyl-l-leucine (prohibited if not provided as imp); 4. riluzole; 5. gabapentin; 6. varenicline; 7. chlorzoxazone; 8. sulfasalazine; 9. rosuvastatin.