Kornimate/medical-research-clean huggingface dataset:
comparing the prognosis of lactate-directed and goal-directed therapy in hyperthermic intraperitoneal chemotherapy.

Conditions: Organ Failure, Multiple

Summary: hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. for anesthesiologist, the intra-operative fluid control is always a big challenge. we try to compare the prognosis of lactate-directed and goal-directed therapy. we expect to confirm the better prognosis of lactate-directed therapy.


Eligibility criteria:
inclusion criteria: * patients receiving hyperthermic intraperitoneal chemotherapy exclusion criteria: * unable to set arterial line severe liver or renal disease severe heart disease unconscious patients
pancreatic cancer early detection registry

Conditions: Pancreatic Cancer

Summary: identify individuals who are at moderate and high risk or predisposed to developing pancreatic cancer with a familial history in which data collected from this study will be used to identify clinical factors associated with early detection of pancreatic cancer.

pancreatic cancer is the fourth leading cause of cancer death in both men and women in the united states. in 2015, there were 49,000 new diagnoses with 41,000 deaths . a recent analysis of the pedigrees in the national familial pancreatic tumor registry found that individuals with a family history of pancreatic cancer in first-degree relatives are at an increased risk of developing pancreatic cancer themselves. there are more than a dozen inherited germline mutations that increase the risk of pancreatic cancer in these family members. in an attempt to lower the number of individuals that develop advanced pancreatic cancer, an early-detection program is created to detect tumors at a stage early enough that treatment is likely to be successful. numerous treatment options exist such as surveillance, radiation therapy, systemic therapy and surgery. determining which treatment option will be implemented is based on the stage and grade of the tumor/cancer.

Eligibility criteria:
inclusion criteria: 1. eligible subjects must be ≥ 18 years of age 2. meet one of the following criteria: * all affected on the same side of the family (maternal/paternal) unless otherwise specified fdr = first degree relative (parent, sibling, child) * sdr = second degree relative (e.g., aunt, uncle, grandparent, half-sibling, niece and nephew) * tdr = third degree relative (e.g., cousin, half-aunt or half-uncle) * 1 fdr with pancreatic cancer \< age 55 -≥2 fdr, sdr or tdr with pancreatic cancer at any age * genetic syndrome with pancreatic cancer * fdr or sdr with pancreatic cancer at any age and ashkenazi ancestry * fdr or sdr with pancreatic cancer at any age and: * 1 relative with ovarian cancer at any age or * 1 relative with breast cancer ≤50 or * 2 relatives with breast, pancreatic or prostate cancer (gleason score ≥7) at any age * family history of melanoma or * has previously had genetic testing and has been determined to have a pathogenic gene variant. * fdr with a pathogenic gene variant exclusion criteria: 1. prior treatment of pancreatic cancer including radiation therapy, systemic therapy and/or surgery. 2. current treatment of pancreatic cancer including radiation therapy, systemic therapy and/or surgery.

Keywords: pancreatic cancer hereditary high risk
safety & effectiveness on vascular structure and function of acz885 in atherosclerosis and either t2dm or igt patients

Conditions: Diabetes Mellitus, Type 2; Atherosclerosis; Prediabetic State

Summary: this study will evaluate the effect of acz885 on vascular function in patients with documented atherosclerotic disease and t2dm or igt.


Eligibility criteria:
inclusion criteria: * patients with known atherosclerotic disease and documented diagnosis of t2dm for ≤ 14 years or igt * hba1c between 6.0% and 10.0% * on stable statin therapy or statin intolerant * patients who are eligible and able to participate in the study exclusion criteria: * contraindications to mri * nyha class iv heart failure * nyha class i - iii heart failure with acute exacerbation in 3 months prior to screening * patients with type 1 diabetes * acute infections * hscrp \> 30 mg/dl * aortic aneurysm ≥5cm other protocol-defined inclusion/exclusion criteria may apply

Keywords: atherosclerosis, type 2 diabetes mellitus, t2dm, cardiovascular diseases, acz885, impaired glucose tolerance, igt, canakinumab
the listening project at the add centre and biofeedback institute of toronto

Conditions: Auditory Perceptual Disorders; Stress Disorder

Summary: purpose: a research project will be conducted at the add ("attention deficit disorder") centre and biofeedback institute of toronto to evaluate the feasibility of the listening project protocol (lpp) intervention in individuals with difficulties with autonomic and/or behavioral regulation. the lpp is designed as a "neural exercise" to reduce auditory hypersensitivities, to improve auditory processing of speech, and to improve behavioral state regulation. these improvements should translate into increase feelings of safety and calmness, thereby promoting improvement in social behavior. participants: 30 participants, males and females between ages 7-55 years, will be recruited for the study. participants will be patients at the add centre and biofeedback institute of toronto. procedures: participants will be divided into 1 of 2 groups (1:1 ratio). both groups will have a pre-intervention assessment #2, intervention, 1 week post intervention assessment and 1 month post intervention assessment. group 2 will have an additional pre-intervention assessment session #1 (1 week previous to pre-intervention assessment #2) to assess the stability of the measures prior to starting the intervention. pre-, post-, and 1 month followup assessment will include parent and/or self-report questionnaires, and measures of the individual's auditory processing ("scan"), affect recognition ("dare" dynamic affect recognition evaluation), heart rate, prosody, "rsa" respiratory sinus arrhythmia (derived from non-invasive ecg recording), and middle ear transfer function ("mesas" - middle ear sound absorption system).


Eligibility criteria:
inclusion criteria: 1. individuals must be between ages 7-55 years 2. individuals must be fluent (read and write) in english. parents must be able to read/speak in english. 3. individuals must be current or past clients at the add centres limited \& biofeedback institute of toronto exclusion criteria: 1. individuals who wear a hearing-device 2. individuals with a history of heart disease 3. individuals who are currently being treated for seizure disorder 4. individuals who are non-verbal

Keywords: autonomic nervous system auditory processing disorder social behavior
effects of home-based program in improving sitting balance and upper limb functions in patients with stroke

Conditions: Stroke

Summary: the investigators hypothesize that application of electrical stimulation would augment the effects of exercises in patients with stroke. combined electrical stimulation with exercises for 6 weeks would lead to earlier and greater improvement in motor functions when compared with placebo-stimulation with exercises.

previous studies have shown that repeated sensory inputs from transcutaneous electrical stimulation (tes) could enhance brain plasticity and conical motor output. home-based rehabilitation is shown to be effective in motor recovery and improvement of functional ability in stroke rehabilitation. the aim of this study was to develop a home-based rehabilitation program to investigate whether combined electrically induced sensory inputs through tes with task-related trunk training (trtt) in a home-based program would induce earlier and/or greater improvement in, seated reaching distance and trunk control when compared with placebo tes and trtt, or control with no active treatment in subjects with chronic stroke.

Eligibility criteria:
inclusion criteria: 1. diagnosis with first stroke for more than 6 months 2. discharge from all rehabilitation services 3. ability to understand and follow commands 4. a carer able for helping the home program 5. no contraindication to assessment protocol and training exclusion criteria: 1. cognitive disorder with abbreviated mental test less than 7 2. unilateral neglect with star cancellation test less than 47 3. sensory deficit 4. unable to give informed consent 5. unable to speak either cantonese or english or mandarin 6. commodity that preclude them from undergoing training and assessment 7. neurological disease other than stroke

Keywords: sitting balance stroke
inflammatory cytokine quantification in infants

Conditions: Sepsis; Congenital Diaphragmatic Hernia; Neonatal Cardiopulmonary Failure

Summary: this study proposes to quantify inflammatory cytokine profiles in three neonatal disease states, namely, neonatal sepsis, infants with a congenital diaphragmatic hernia defect, and infants suffering cardiopulmonary failure significant enough to require heart/lung bypass treatment with extracorporeal membrane oxygenation (ecmo).

very small blood samples (500 microliters) will be collected serially in these patients and analyzed with current cytokine array technology. a convenience sample of 60 patients, 20 with each of these diagnoses, will be collected over a 2 year period. these data will provide baseline information for possible therapeutic intervention with agents that enhance or suppress specific mediators, or adjust mediator balance to promote patient healing.

Eligibility criteria:
inclusion criteria: * gestational age ≥ 34 weeks, * indwelling vascular catheter available for blood draws, * documented culture positive sepsis on vasopressors , and/or * congenital diaphragmatic hernia (cdh), and/or * ecmo therapy exclusion criteria: * other major congenital anomalies * lack of parental consent

Keywords: inflammatory cytokines extracorporeal membrane oxygenation ecmo
open or laparoscopic mesolectal excision in low rectum cancer

Conditions: Rectal Cancer

Summary: to compare the open approach and the laparoscopic-assisted approach of dissection of lateral lymph nodes in low advanced rectal cancer patients with clinically suspected nodal metastases in terms of safety, technical feasibility, and patient's oncological outcomes.

the investigators collected data of sixty low advanced cancer rectum patients who underwent either laparoscopic (30 cases) or open total mesorectal excision (30 cases) in addition to lateral pelvic dissection. the duration of operation in the laparoscopically assisted procedure was longer than the open procedure (p=0.003). the postoperative hospital stay time was longer in the open group than in the laparoscopic group (p=0.043). no significant differences between both groups regarding the number of excised lymph nodes, disease recurrence, rfs, or os rate.

Eligibility criteria:
inclusion criteria: * patients aged from 20-70 years with * sure diagnosis of locally advanced (t3 and t4) adenocarcinoma located in the middle or lower part of the rectum * clinical or radiological evidence of lateral pelvic lymph nodes metastases exclusion criteria: * patients refused to be included in the study, * patients with concurrent primary cancer in other locations * patients with recurrent cancer after treatment * patients with distant metastasis * previously managed for pelvic cancer
evaluation of gingival health parameters in hybrid cad / cam crowns produced after different retraction processes

Conditions: Periodontal Disease; Gingival Disease

Summary: clinically, the gingival retraction dentistry itself has found wide uses. it has achieved the use of subgingival and gingival crowns in fixed prostheses, cervical abrasion in restorative dentistry, management of root caries and root sensitivity, and recently in the use of appropriate measurements to improve the marginal fit of implant prostheses.there are three different retraction procedures described in the literature: mechanical, mechanical-chemical (chemically impregnated cords or matrix in injectable form) and surgery (electrosurgical, laser, cauterization, etc.)the mechanical method of retraction cords is not always suitable for patients' existing pocket depth, the necessity of using different combinations in shallow or deep pockets, the potential for limited bleeding control in chemically impregnated cords and the toxicity values in those who interact with chemical have led researchers to search for alternative methods. especially inflammed gingiva is very sensitive to mechanical and chemical trauma. studies have reported that gingival inflammation, pain, pocket formation, gingival withdrawal, increased bleeding and wound contamination occurred following retraction cord application. however, it is a known fact that the impression material is distorted or the accuracy of the measurement is decreased with the measurements taken without retraction. nowadays, cad / cam (computer-aided design / computer-aided manufacturing) devices, which are designed to overcome these problems and eliminate the errors related to the measurement material, are the first step to be taken with a clear measure.gingival retraction is recommended to improve the success of scanners in all restorations performed at the gingival or subgingival endpoint. therefore, in our study, crown restorations will be produced from hybrid blocks by means of cad / cam device in order to evaluate the interaction of gingival health with hybrid blocks and to provide the latest technology and standardization.


Eligibility criteria:
inclusion criteria: * being systemically healthy * to indicate crown restoration in mandibular molar teeth * to be vital to the preparation of the crown of the teeth exclusion criteria: * systemically unhealthy individuals * endodontic treatment of mandibular molar teeth * mandibular molar female individuals drawn for various reasons * pregnant women * periodontally unhealthy individuals

Keywords: cad/cam gingival retraction
comparison of the accuracy of telehealth examination versus clinical examination in the detection of rotator cuff tears

Conditions: Rotator Cuff Tear

Summary: the purpose of this study is to compare how accurately a pseudo-telehealth shoulder examination diagnoses rotator cuff tears compared to a regular clinical examination. mri is used as the gold standard.


Eligibility criteria:
inclusion criteria: * 40 years of age or older, presenting with shoulder pain, and seen in the duke sports medicine clinic by dr. wittstein or dr. lassiter exclusion criteria: * patient cannot have had prior shoulder arthroplasty, instability or history of fracture/dislocation. pregnant women will be excluded from the study because there will be an mri. anyone unable or unwilling to have an mri will be excluded from the study.
perception about upper limb functional recovery, barriers & use of training devices among indian stroke survivors.

Conditions: Stroke, Middle Cerebral Artery With Infarction, Rehabilitation, Upper Limb Recovery, Economic Burdon

Summary: the goal of this observational study is to evaluate perceptions regarding affected arm and hand function and their willingness to use devices to enhance upper limb functions among stroke survivors. the main question\[s\] it aims to answer are: * what will the stroke survivor's perception of interventions and device development in his/her arm recovery? * wheather he is willing to use it for his arm recovery?

individuals with stroke will be recruited from mgm hospital and other hospitals from aurangabad. participants will be adults (age \>30) with stroke and with the capacity to provide written or verbal informed consent, and the ability to communicate verbally/online/phone. participants will be contacted via phone or email by a member of the research team. if needed personal interviews of the patients will be taken. the research team will consist of the author and one helper physical therapy student and the guide. all team members participating in the training will ensure consistency in communications with participants. all the participants will be provided with information about the study objectives and procedures and will be asked if they are willing to participate. if they consent, they will be given one of three options: 1. complete the survey via phone immediately 2. complete the survey online. in this case, they will be sent a link to their email to complete an online survey. 3. complete the survey via personal interview

Eligibility criteria:
* inclusion criteria: * first-ever stroke * all stages of stroke * onset of a stroke at least 1 year ago * age group: 30 to 75 * both genders included * patients diagnosed with mca (middle cerebral artery) stroke * exclusion criteria: * aphasia * patients who are unable to follow commands * patients with other neurological disorders such as multiple sclerosis and parkinson's disease
effect of motor entrainment to auditory cues and music during walking on quality of movement and perceived fatigue in persons with multiple sclerosis (pwms)

Conditions: Multiple Sclerosis

Summary: the study investigates the effect of different conditions of auditory cueing and music on walking quality and perceived fatigue in persons with multiple sclerosis compared to healthy controls. the study extends over a four session period, each session lasting maximally 1h30 minutes the experimental conditions include participants walking to music and metronome (at different tempi) for 3minutes and 15 seconds per condition, with a rest period of 3 minutes in between each condition. non-invasive equipment will be used. participants are equipped with sensors (watch-like straps at the wrists, ankles and across the chest) and are given wireless headphones.


Eligibility criteria:
inclusion criteria: * diagnosis of ms of \>1 year, * no relapse in the last 1 month, * ability to walk for 12 minutes without interruption, * an average usual walking speed between the range of 0.4 and 1.2 m/s. exclusion criteria: * cognitive impairment hindering the understanding and execution of the experimental procedures * pregnancy * hearing impairment * amusia * beat deafness
real-time pcr for the detection of vaginal group b streptococcus carriage: a medico-economic study

Conditions: Neonatal Infections; Streptococcus Agalactiae

Summary: group b streptococcus infections may be serious for the neonates. the infection can occur during the birth, by contact with the genital area. that is why the detection of this bacteria is systematically realised in pregnant women between 34 and 37 weeks of amenorrhea in order to give prophylactic antibiotic treatment in case or positive carriage. this strategy presents 2 disadvantages : (1) detection of the group b streptococcus at 34 and 37 weeks of amenorrhea in not predictive of a carriage at delivery, (2) many pregnant women escape from systematic screening, leading to a systematic antibiotic treatment, which means useless costs, and useless antibiotic exposure with resistant bacteria selection. real time polymerase chain reaction (pcr) allows a rapid detection anytime with no specific microbiological qualification. the aim of the study is to assess the economic outcomes of this strategy and the epidemiological values for st etienne hospital.


Eligibility criteria:
inclusion criteria: * women giving birth exclusion criteria: * planned caesarian * minor * cervical diameter \> 5 cm * women giving birth at less than 35 weeks of amenorrhea * recent antibiotherapy

Keywords: screening real time pcr streptococcus agalactiae pregnant women
target kids!: measuring nutrition in young preschool children in the primary care practice setting

Conditions: Nutritional Disorders; Obesity; Development

Summary: target kids! (the applied research group for kids) is a research study enrolling healthy children aged 0-5 years. the aim of the target kids! registry is to link early life exposures to health problems including obesity, micronutrient deficiencies, and developmental problems. target kids! represents an innovative collaboration between child health researchers and children's primary care doctors (pediatricians and family physicians) to promote research that really matters and create solutions to some of the today's biggest health concerns. the results of this collaborative research study are not only improving the quality of children's healthcare but also the health of children across the country. coordinated by sick kids and st. michael's hospital with data management services by the applied health research centre (ahrc), target kids! is the only primary care research network for children in canada.


Eligibility criteria:
inclusion criteria: * birth to less than 6 years of age * parental consent * attending a target kids! research network practice exclusion criteria: * chronic illness with the exception of asthma
comparison of midazolam or dexmedetomidine on epileptiform eeg during sevoflurane mask induction

Conditions: Inhalation Anesthesia

Summary: induction with high sevoﬂurane concentrations may trigger epileptiform electroencephalographic activity without motor or cardiovascular manifestations in healthy patients. no other symptoms were associated in this series, and only electroencephalographic monitoring allowed the diagnosis. midazolam and dexmedetomidine are sedatives commonly used in children before surgery. although the mechanisms are different, both have been reported in antiepileptic effects. this study was designed to compare the effects between intranasal midazolam or dexmedetomidine on epileptiform eeg during sevoflurane mask induction in children. anaesthesia was induced with 8% sevoﬂurane. the patients were randomly assigned to group a (n=15, preoperative intranasal normal saline), group b (n=15, preoperative intranasal 0.25mg/kg midazolam), and group c (n=15, preoperative intranasal 1μg/kg dexmedetomidine). an electroencephalogram was recorded before and during induction up to 10 min after the start of induction.


Eligibility criteria:
inclusion criteria: * asa physical status 1-2 * scheduled for general anesthesia exclusion criteria: * patients with a history of neurological, mental illnes * patients with a history of congenital heart disease * patients with a history of allergies to related drugs

Keywords: sevoflurane epileptiform eeg midazolam dexmedetomidine
vedic counselling for women victims of domestic abuse

Conditions: Intimate Partner Violence; Post Traumatic Stress Disorder

Summary: the vedic counselling is the whole person approach, system of total life style counselling based on 'vedic laws of right living, right actions, right relationship and right awareness'.vedic counselling was developed as trauma focused therapy for this study to treat female victims of domestic abuse.


Eligibility criteria:
inclusion criteria: * female survivors of domestic abuse * 18 years old or older * sign informed consent exclusion criteria: * severe mental illness that requires specialized treatment * terminally ill * under psychiatric medication * chronic illnesses