Kornimate/medical-research-clean huggingface dataset:
efficacy of non-animal chondroitin sulphate for overweight subjects with knee ostoarthritis.

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis (oa) is predicted to become the fourth leading cause of disability worldwide by 2020. and is estimated to affect more than 40 million people in europe and 4 million people in italy. oa has multifactorial etiology and obesity is one of the most important risk factor for knee regarding therapy of oa in 2014, the european society for clinical and economic aspects of osteoporosis and osteoarthritis (esceo) published a treatment algorithm for the management of knee oa. in step 1 of the treatment, it is recommended to initiate therapy with chronic symptomatic slow-acting drugs for osteoarthritis (sysadoas). among sysadoas, the evidence is greatest for the effect of chondroitin sulfate (cs). sixty overweight subjects with knee osteoarthritis (oa) were recruited and randomly allocated to a group of treatment with 600 mg/d of non-animal chondroitin sulphate (cs) or to a placebo group. these measurements were considered: tegner lysholm knee scoring (tlks), western ontario and mcmaster universities arthritis (womac) index and visual analogue scale (vas) for pain were analyzed at time 0 and at 4 and 12 weeks. health-related quality of life by shortform36, inflammation by c-reactive protein (crp) and erythrocyte sedimentation rate (esr) were also evaluated, together with a body composition assessment performed by dxa.


Eligibility criteria:
inclusion criteria: * caucasian subjects, males and females, with the following characteristics were included in the trial and randomly assigned to the experimental group (n=30) or a control group (n=30): individuals overweight (bmi \> 25 kg/m2), aged 40-74.; mobility impairment, joint discomfort or established moderate knee oa (classification 1-3 according to kellgren and lawrence system for classification of knee oa). exclusion criteria: * anyone with evidence of heart disease, kidney or liver disease, or any other disease that might influence the results of the study was excluded.

Keywords: non-animal chondroitin sulphate knee osteoarthritis overweight
benefits management for people with psychiatric disabilities

Conditions: Dual Diagnosis; Schizophrenia; Bipolar Disorder

Summary: this stage 1 clinical trial will determine pilot efficacy, develop a therapy manual, and collect qualitative data concerning a brief money management intervention for people disabled by psychiatric illnesses.


Eligibility criteria:
inclusion criteria: * has received treatment for a psychiatric disorder within 60 days of enrollment * receives ssi or ssdi payments totaling at least $600 per month * has an identified outpatient clinician * either i) homeless within the past 3 months. homeless is defined as having spent at least seven days in a shelter, outdoors (e.g. in a park, in a car), in a public or abandoned building (e.g. train station), or temporarily (less than a continuous month) housed by family or friends or ii) hospitalized within the past 3 months justification for inclusion criteria: homelessness and hospitalization are common reasons for payee assignment (conrad, matters et al. 1998). in a prior study, we found that a high proportion of hospitalized inpatients meet criteria for needing a payee (rosen, rosenheck et al. 2002a). there is no point enrolling clinically stable outpatients in this study because they are unlikely to need payees. exclusion criteria: * already has a conservator or representative payee * an application to assign a payee or conservator has been initiated * unable to speak and understand english

Keywords: disability social security representative payee
oral anti-coagulants in fragile patients with percutaneous endoscopic gastrostomy and atrial fibrillation (origami) pilot study

Conditions: Atrial Fibrillation

Summary: compelling evidences support the safety of direct oral anticoagulants (doac) compared to vitamin k antagonists (vka) in patients with non-valvular atrial fibrillation. the 2018 ehra/esc practical guide on the use of non-vitamin k antagonist oral anticoagulants stated that "data have shown that administration in a crushed form (e.g. via a nasogastric tube), does not alter the bioavailability for apixaban, rivaroxaban, and edoxaban". however, at the moment, there are no evidences supporting unequivocally the use of doac via peg. the purpose of this study is to evaluate the safety and efficacy of edoxaban administered through peg in patients with an indication of anticoagulation according to the current clinical practice.

several studies support the safety of direct oral anticoagulants (doac) compared to vitamin k antagonists (vka) in patients with non-valvular atrial fibrillation. the 2018 ehra/esc practical guide on the use of non-vitamin k antagonist oral anticoagulants affirmed that "data have shown that administration in a crushed form (e.g. via a nasogastric tube), does not alter the bioavailability for apixaban, rivaroxaban, and edoxaban". however, at the moment, there are no evidences supporting unequivocally the use of doac via percutaneous endoscopic gastrostomy (peg). peg is a method developed throughout the early 1980s for patients who need long-term enteral nutrition due to neurodegenerative, neuromuscular and oncological diseases. this class of patients is expected to increase significantly in the next decade. several studies have proven the safety of doac compared to vka even recommending to prefer doac over vka wherever possible in the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation. however, there is no evidence to support unequivocally the use of doac in patients fed peg. the purpose of this study is to evaluate the safety and efficacy of edoxaban administered through peg in patients with an indication of anticoagulation according to the current clinical practice.

Eligibility criteria:
inclusion criteria: * patients with peg and indication for treatment with long-term oral anticoagulant therapy * patients with atrial fibrillation exclusion criteria: * children under 18 years old. * life expectancy \<30 days. * lack of informed consent.
efficacy of 2% chlorhexidine gluconate in 70% alcohol compare 10% povidone iodine in blood culture in children

Conditions: Bacteremia

Summary: to evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.

this is a prospective study of pediatric patients between 0-15 years of age who were admitted in three pediatric wards: general pediatric ward aged \ 5 years, and pediatric intensive care unit at a tertiary-care teaching hospital. patients who needed percutaneous blood cultures were eligible for enrollment and were classified into two groups according to antiseptic used: 10% povidone iodine in odd months and 2% chlorhexidine gluconate in 70% alcohol in even months. blood cultures were taken primarily by ward nurses using standard technique. the blood cultures were analysed and monitored for 5 days. isolated organisms and their antimicrobial susceptibilities were determined using standard microbiologic techniques. blood culture isolates were categorized into two groups including a true pathogen and a contaminant by clinical criteria combined with laboratory data. a blood culture was classified as contaminated if common skin flora such as coagulase negative staphylococci, corynebacterium spp., micrococcus spp., or bacillus spp. were isolated from one of the blood culture samples without isolation of the same organism from another potential infection site (for example, intravenous catheter), or a common skin flora was isolated in a patient with incompatible clinical features and improved without specific treatment for that organism.

Eligibility criteria:
inclusion criteria: * pediatric patients between 0-15 years of age who were admitted in three pediatric wards: general pediatric ward aged \ 5 years, and pediatric intensive care unit. patients who needed percutaneous blood cultures were eligible for enrollment. exclusion criteria: * preterm infant * patient who had skin infection at site of venepuncture * patient who had history allergy to 2% chlorhexidine gluconate in 70% alcohol or 10% povidone-iodine

Keywords: blood culture contamination chlorhexidine gluconate povidone iodine
use of micropulse trans-scleral cyclophotocoagulation laser (mp-tscpc) for glaucoma patients

Conditions: Glaucoma

Summary: the purpose of this study is to evaluate the clinical outcomes of the micropulse trans-scleral cyclophotocoagulation laser (mp-tscpc) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up, with the intent to evaluate the efficacy of using mp-tscpc to treat glaucoma patients.

patients will be submitted to mp-tscpc throughout the year of 2020, according to parameters determined by the principal investigator and executed by the principal investigator, after signing the consent form and agreeing on having their data used for research purpose. postsurgical follow up visits will be scheduled for 1 month, 3 months, 6 months and 12 months. patients iop, number of medications, visual acuity, visual field, iris color, retinal nerve fiber layer thickness on oct and any complications (iritis, corneal edema, hyphema, vitreous hemorrhage, vision loss, cataract progression or hypotony maculopathy) will be measured by trained ophthalmic assistants supervised by the principal investigator and documented at each visit. authorized mayo clinic personnel will perform chart reviews; using administrative data as designated by dr. dorairaj. the data will be statistically analyzed to illustrate the results and determine if the objectives and primary and secondary endpoints were achieved

Eligibility criteria:
inclusion criteria: * diagnose of glaucoma * indication to be submitted to the procedure exclusion criteria: * significant thinning of the sclera * current eye infection or inflammation * intraocular surgery performed less than 2 months prior to the enrollment in the study
transapical transcatheter treatment versus conventional surgery in patients with native aortic valve stenosis

Conditions: Aortic Valve Stenosis

Summary: this study is a randomised comparison of apical stent valve treatment versus conventional valve surgery in patients with severe aortic valve stenosis.

the purpose of the study is to compare the new established apical stent valve treatment with conventional surgical intervention using biological valve prostheses in patients with severe aortic valve stenosis. the edwards-sapientm transcatheter heart valve (edwards lifesciences, irvine, ca) will be used in the stent valve group. the carpentier-edwards-perimount heart valve (edwards lifesciences, irvine, ca) will be recommended for the conventional surgery group.(edwards lifesciences, irvine, ca). heart centres in the nordic region with experience (\>10 cases) in apical stent valve treatment and in conventional surgical treatment of high risk patients with aortic valve stenosis. the study will be initiated at aarhus university hospital, skejby, denmark. study hypothesis: as compared to conventional aortic valve substitution in patients aged \>75 years, apical stent valve treatment reduces the rates of death, cerebrovascular insult (cvi) and need of dialysis for renal failure 1 month after the treatment. primary clinical end-point: combined end-point consisting of death, cvi and/or renal failure with need for haemodialysis, 1 month after index treatment.

Eligibility criteria:
inclusion criteria: * significant aortic valve stenosis (valve area \< 1cm2) * age \> 75 (years aarhus university hospital, skejby) * age \> 80 years (other participating centres) * operable by conventional surgery and transapical stent valve implantation * expected survival \> 1 year following successful treatment * accept of participation and in follow-up investigations after adequate information * informed consent exclusion criteria: * coronary artery disease requiring pci or cabg * earlier cardiac surgery * myocardial infarction within 24 hours * kidney failure requiring any dialysis * ongoing infection * acute surgery * allergy to asa or clopidogrel

Keywords: aortic valve stenosis stent valve biological aortic valve prosthesis
cerebellar rtms for essential tremor

Conditions: Essential Tremor

Summary: essential tremor (et) is a low-mortality, though truly burdensome and debilitating condition which is known to be the second most common movement disorder of the adult population only after restless legs syndrome. the prevalence of the disorder in all age groups has been estimated to be 0.9%. repetitive transcranial magnetic stimulation (rtms) is an almost safe technique which has been used in diagnosis and treatment of many neurologic and psychiatric conditions. recent studies have shown that cerebellum has a significant role in development of et and that rtms could exert therapeutic effects on its motor symptoms. in this study researchers will recruit at least 30 subjects among patients visiting at the specialty clinic of mashhad medical university according to researchers exclusion and inclusion criteria and after signing a written informed consent, will randomly be assigned to either real or sham rtms. on the real rtms arm, patients will be treated with 900 pulses of 1 hz rtms on 90% of resting motor threshold (rmt) delivered over each cerebellar hemisphere for 5 consecutive days and sham treatment will be performed with the same protocol using a small device placed on the tms coil (not visible to the patients) producing electrical stimulation (less than 3 mili amperes), to simulate the sensation of real tms. subject's ear will be protected with earplugs during both real and sham stimulations. after 2 months of follow-up, patients will undergo crossover and receive the other treatment as described above. patients would be assessed using fahn-tolosa-marin scale at the baseline and again on days 5, 12, and 30 after each real or sham treatment session by a blinded researcher. data will be analysed by another researcher who is also blind.


Eligibility criteria:
inclusion criteria: * having a diagnosis of essential tremor (et) based on movement disorder society criteria, involving at least one hand. * 18 years or above * cognitively eligible to give informed consent of participation in the trial. exclusion criteria: * cardiac pace-maker or other implanted magnetic device or having other contraindications of performing a routine non-contrast mri * skin defect at the occipital area preventing placement of a coil * currently pregnant or plan for pregnancy in the next 6 months * history of seizure * other comorbid medical conditions capable of producing or enhancing tremor * advanced cardiac, renal, hepatic or other disabling conditions making patient physical unable to participate in examination and receiving the intervention * use of new drugs with potential effect on tremor
janus ii feasibility

Conditions: Sleep Apnea

Summary: the objectives of this study are to evaluate the feasibility of the remedē® dual channel system at implant and overnight sleep studies and to assess chronic safety.


Eligibility criteria:
inclusion criteria: * severe sleep disordered breathing * expected to tolerate study procedures * no heart failure or medically stable heart failure exclusion criteria: * currently implanted with a neurostimulator to treat sleep disordered breathing without sponsor approval * history of severe copd or pulmonary arterial hypertension * current or previous history of nerve injury or palsy * prior cervical surgeries or radiation treatment to head region * known need for an mri * history of psychosis or severe bipolar disorder * active infection or sepsis within 30 days of enrollment * currently on kidney dialysis or significantly reduced kidney function * hemoglobin less than 8g/dl * pacemaker dependance * new defibrillator or any implantable device or device generator changeout within 30 days prior to study implant or anticipated within the first 12 months * other conditions or anticipated surgical procedure expected to affect ability to complete study procedures * allergy to contrast dye unless can be prophylactically treated * known pregnancy or planning to become pregnant
effects of a mindfulness meditation app on subjective well-being in undergraduate university students

Conditions: Stress, Psychological

Summary: mindfulness training includes a variety of contemplative practices aimed at promoting intentional awareness of experience, coupled with attitudes of non-judgment and curiosity. following the success of 8-week, manualized group interventions, mindfulness training has been implemented in a variety of modalities, including smartphone apps that seek to replicate the success of group interventions. however, although smartphone apps are scalable and accessible to a wider swath of population, their benefits remain largely untested. this study aimed to investigate a newly developed mindfulness training app called wildflowers, which was co-developed with the laboratory for use in mindfulness research. it was hypothesized that 3 weeks of mindfulness training through this app would improve subjective well-being, attentional control, and interoceptive integration, albeit with weaker effects than those published in the 8 week, manualized group intervention literature.

background: mindfulness training includes a variety of contemplative practices aimed at promoting intentional awareness of experience, coupled with attitudes of non-judgment and curiosity. following the success of 8-week, manualized group interventions, mindfulness training has been implemented in a variety of modalities, including smartphone apps that seek to replicate the success of group interventions. however, although smartphone apps are scalable and accessible to a wider swath of population, their benefits remain largely untested. this study aimed to investigate a newly developed mindfulness training app called wildflowers, which was co-developed with the laboratory for use in mindfulness research. it was hypothesized that 3 weeks of mindfulness training through this app would improve subjective well-being, attentional control, and interoceptive integration, albeit with weaker effects than those published in the 8 week, manualized group intervention literature. methods: undergraduate students completed 3 weeks of mindfulness training with wildflowers or 3 weeks of cognitive training with a game called 2048. state training effects were assessed through pre- and postsession ratings of current mood, stress level, and heart rate. trait training effects were assessed through pre- and postintervention questionnaires canvassing subjective well-being and behavioral task measures of attentional control and interoceptive integration. state and trait training data were analyzed in a multilevel model using emergent latent factors (acceptance, awareness, and openness) to summarize the trait questionnaire battery.

Eligibility criteria:
inclusion criteria: * normal or corrected-to-normal vision and hearing * be fluent in english * own an iphone, ipad, or ipod with access to the internet

Keywords: mindfulness attention mobile health interoception mood
the impact of supervision by a health care professional on quality of life questionnaire

Conditions: Health-related Quality of Life

Summary: effect of supervision on scoring and completion on quality of life questionnaire

this protocol will study the impact of supervision on completion and scoring of sensitives domains of qol questionnaires and qol questionnaires in general in a multi-center, randomized, cross-over design in cancer patients receiving systemic antineoplastic therapy

Eligibility criteria:
inclusion criteria: * patient is ≥18 years of age and legally competent * signed informed consent available * systemic oncologic treatment (e.g. chemotherapy, immunotherapy, endocrine therapy) * current systemic therapy started at least 4 weeks before randomization and is scheduled to continue for at least another 4 weeks after randomization in the same dose and interval * patient is ready and able to complete quality of life questionnaires in german (on paper exclusion criteria: * one or more of the inclusion criteria not met.
retrospective analysis of perioperative anesthetic care and analgesia management of patient undergoing bilateral myringotomy with tube insertion

Conditions: Otitis Media With Effusion (OME)

Summary: this is a retrospective chart review. the purpose of this study is to retrospectively examine the use of perioperative analgesics on the incidence of postoperative pain and emergence delirium in patients undergoing bilateral myringotomy with tube insertion (bti), as well as events associated with treatment including postoperative vomiting and time to discharge.


Eligibility criteria:
inclusion criteria: * patients who underwent myringotomy with tube insertion from january 1, 2015 through february 28, 2015 at nch. exclusion criteria: * none
an open study of tipepidine hibenzate in patients with attention deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: accumulating evidence suggests a role of g protein-coupled inwardly-rectifying potassium (girk) channel in the pathology of excitement of nerve, and the medicine with the action (like the tipepidine hibenzate) is expected as a new curative medicine of attention deficit / hyperactivity disorder (ad/hd). the purpose of this research is to confirm the effect by carrying out the additional dosage of the tipepidine hibenzate to the ad/hd patients. if suggestion is obtained by this research about the effect on ad/hd of tipepidine hibenzate, it can contribute to development of the medical treatment of ad/hd.


Eligibility criteria:
\[inclusion criteria\] 1. attention-deficit/hyperactivity disorder (ad/hd) for dsm-iv tr criteria. 2. patients are treated with atomoxetine, methylphenidate, atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, perospirone, aripiprazole, blonanserin, paliperidone) or not treated. 3. patients are stable for 4-weeks for medication. \[exclusion criteria\] 1. patients with a previous hypersensitivity to tipepidine hibenzate. 2. patients treated with typical antipsychotics and selective norepinephrine reuptake inhibitor (nri) except atomoxetine and stimulants except methylphenidate. 3. pregnant or breast-feeding women
intraoperative biodegradable stent placement to reduce complications after pancreatoduodenectomy

Conditions: Fistula Pancreatic

Summary: the aim of this prospective, randomized, blinded clinical superiority trial is to establish intraoperative placement of biodegradable stents in the pancreatojejunostomy as a safe, effective, and feasible preventive measure against pancreatic fistula following pancreatoduodenectomy. the investigators hypothesize that intraoperative placement of biodegradable stents in the pancreatojejunostomy is safe and can reduce the risk of pancreatic leakage following pancreatoduodenectomy in patients who have not undergone pbd.


Eligibility criteria:
inclusion criteria: 1. patients undergoing a pancreatoduodenectomy 2. patients aged 18 or above 3. patients who have given an informed consent exclusion criteria: 1. patients who do not or cannot give an informed consent. 2. patients with at a high risk or with previous history of multiple thrombo-embolic diseases or bleeding disorders. 3. patients undergoing active immunosuppressive therapy.

Keywords: fistula postoperative pancreatic fistula pancreatoduodenectomy
causes of chronic pruritus

Conditions: Chronic Pruritus

Summary: the aim of this study is to include all patients followed between 2008 and 2018 in order to analyze the etiologie of the chronic pruritus


Eligibility criteria:
inclusion criteria: * more than 18 years old * in patient in a day hospital or longer hospitalization in the dermatology department * with chronic pruritus which means pruritus longer than 6 weeks without skin lesions specific to pruritic dermatitis. exclusion criteria: * itchy dermatose * refusal to particpate