Kornimate/medical-research-clean huggingface dataset:
acupuncture with/without self-acupressure for post-oophorectomy hot flashes in brca carriers

Conditions: Hot Flashes; Menopause Surgical

Summary: risk-reducing surgery with salpingo-oophorectomy (rrso) is the standard recommended treatment for all female carriers of brca genes 1 and 2. the post-surgical menopause induced is invariably accompanied by hot flashes and other symptoms, which can severely impair quality of life and function. hormone-replacement therapy (hrt) is the standard conventional treatment for these symptoms, though these drugs do not always provide adequate relief and many patients either cannot receive them due to a diagnosis of breast cancer or hypercoagulable state; or are unwilling to take them due to their concern about the associated increased risk for developing hormone-induced breast cancer. acupuncture and acupressure have been researched extensively and shown to be both safe and effective in reducing hot flashes in post-menopausal patients and in those with breast cancer receiving anti-hormonal drugs. the present study will examine the effectiveness of acupuncture, with/without self-acupressure, on 200 post- rrso patients who suffer from at least 5 hot flashes per day, including those treated with hrt. all participants will receive 8 weekly treatments with acupuncture, and then randomly assigned to receive (or not) self-administered acupressure, to be performed daily at home. the response to the study interventions will be assessed using daily hot flash scores, the menopause specific quality of life (menqol) and measure yourself concerns and wellbeing (mycaw) questionnaires (at baseline; at the end of the 8-week intervention; and at 16 weeks). the safety of the study treatments will be assessed throughout.


Eligibility criteria:
inclusion criteria: * female carriers of the brca 1 and 2 genes * age ≥ 25 years * after risk-reducing salpingo-oophorectomy * reporting ≥ 5 hot flashes per day exclusion criteria: * patients not fulfilling the study inclusion criteria will be excluded from participation

Keywords: acupuncture acupressure hot flashes surgical menopause quality of life
new automated system for continuous real-time monitoring of transpulmonary pressure

Conditions: Acute Respiratory Failure; Ventilator-Induced Lung Injury

Summary: patients admitted to intensive care unit often are affected by acute respiratory failure at admission or during hospital stay, with a mortality of 30%. treatment remains largely supportive with mechanical ventilation as the mainstay of management by improving the hypoxemia and reducing the work of breathing; however, the mechanical forces generated during ventilation can further enhance pulmonary inflammation and edema, a process that has been termed ventilator induced lung injury (vili). consequently, in clinical practice the lung protective ventilation is mainly based on the reduction of the tidal volume, the airway and the transpulmonary plateau pressure. a good clinical practice is based on the assessment of changes in respiratory mechanics. aim of the study is to determine the accuracy of the optivent system in measuring transpulmonary pressure, comparing it with the systems currently in use in our operative unit.


Eligibility criteria:
inclusion criteria: * acute respiratory failure * invasive mechanical ventilation. exclusion criteria: * haemodynamic instability * presence of barotrauma * esophageal disease.

Keywords: ards respiratory mechanics transpulmonary pressure pleural pressure
effect of low-calorie diet on serum lipids, adipokines, insulin resistance and also body composition in women with metabolic syndrome

Conditions: Weight Loss; Insulin Resistance; Adipokines

Summary: the purpose of this study is to evaluate the effect of a hypocaloric diet on biomarkers associated with insulin resistance, metabolic profile and body composition in women with metabolic syndrome.


Eligibility criteria:
inclusion criteria: * bmi of 30-34.9 kg/m2, diagnostic of metabolic syndrome based on national cholesterol education panel atpiii (2002) exclusion criteria: * diabetes mellitus, non-treated thyroid disease, treatment with lipid-lowering drugs and glucocorticoids or weight loss treatment within the previous 3 months.
preventing opioid overdose deaths by empowering pharmacists to dispense naloxone

Conditions: Opioid Overdose

Summary: objectives: the purpose of this study was to assess the impact of the empowering community pharmacists program on pharmacists' knowledge, perceived barriers, attitudes, confidence, and intentions regarding naloxone services implementation, as well as change in number of naloxone prescriptions dispensed. methods: a 3-month pragmatic randomized controlled trial was conducted in 2018-2019. alabama community pharmacists were recruited by email, phone, fax, and mailed postcards and randomized to intervention (monthly resources/reminders + educational webinar) or control (monthly resources/reminders + delayed educational webinar). outcome measures were assessed via online surveys at baseline (t1), immediately post-intervention (t2), and 3-months post-intervention (t3), including: naloxone knowledge (percent correct); perceived barriers, attitudes, and confidence regarding naloxone services implementation (7-point likert-type scale, 1=strongly disagree to 7=strongly agree); and number of naloxone prescriptions dispensed. mean differences between control and intervention groups from t1-t3 were assessed using two-way mixed anova and adjusted analyses were conducted using generalized estimating equations (gee) with negative binomial distribution (alpha=0.05).


Eligibility criteria:
inclusion criteria: * registered pharmacists. * employed at least 30 hours per week at a community pharmacy. * employed at a community pharmacy located in one of 20 alabama priority counties with the highest opioid overdose mortality rates. exclusion criteria: * multiple pharmacists from the same pharmacy site. * members of the stakeholder panel (from the formative phase of the study).

Keywords: naloxone community pharmacy implementation
the effects of fish oil on patients with chronic nonspecific low back pain

Conditions: Chronic Low Back Pain

Summary: objectives: to investigate the efficacy of omega-3 polyunsaturated fatty acids (pufa) on patients with chronic nonspecific low back pain (nlbp). methods and materials: twenty-nine patients with chronic nlbp were randomly divided into experimental and control groups. for 8 weeks, participants in the experimental group received omega-3 pufa at 3000 mg/day plus physical therapy, while those in the control group received placebo plus physical therapy. the visual analog pain scale, pressure algometer, biering-sorenson test, roland-morris low back pain and disability questionnaire (rmq), and occupational burnout inventory (obi) were used in assessments at baseline (t0) and after 4 (t1) and 8 weeks (t2). serum erythrocyte sedimentation rate (esr) and hypersensitive c-reactive protein (hs-crp) were checked at baseline and t2.

low back pain is a common symptom in modern society. however, nearly 85% of those who seek medical care for low back pain have no specific history and no specific finding in image study, and therefore do not receive a specific diagnosis. this type of low back pain is termed "nonspecific low back pain." fish oil contains omega-3 polyunsaturated fatty acid, including eicosapentaenoic acid (epa) and docosahexaenoic acid (dha). epa and dha can reduce the synthesis of prostaglandin e2. they are also the precursors of the e-resolvin and d-resolvin that suppress inflammatory cytokine production and act to resolve inflammation. several previous studies showed that fish oil has the effect of anti-inflammation and pain reduction without side effect that affecting stomach and renal function. therefore, fish oil is considered a new type of nsaid, and many studies are investigating its effect of anti-inflammation and pain reduction on different diseases. the purpose of this study is to investigate the effects of fish oil on patients with chronic nonspecific low back pain.

Eligibility criteria:
inclusion criteria: * male and female aged 20-50 * low back pain duration over 3 months and pain intensity over 40mm when assessed with 100mm vas exclusion criteria: * history of major trauma or surgery at back * obvious spinal pathology on plain film (e.g. scoliosis, spondylosis, spondylolisthesis) * not suitable for taking fish oil or receiving physical modality treatment * having other inflammatory disease (e.g. rheumatic arthritis, endometriosis, ankylosing spondylitis, infection) * pregnancy * regularly taking fish oil or fatty fish more than 2 times per week * having coagulopathy or currently taking anti-coagulation agent * receiving oral or topical nsaid in the past one week * taking oral corticosteroid in the past 6 weeks * receiving local injection of corticosteroid or prolotherapy in the past 3 months

Keywords: low back pain fish oil omega 3
placebo and active controlled study to compare the efficacy of aspirin and paracetamol in treatment of sore throat associated with a common cold

Conditions: Common Cold; Pharyngitis; Tonsillitis

Summary: the purpose of this study is to determine the efficacy and safety of 1000 mg aspirin (study medication) by comparing 1000 mg paracetamol (study medication) in treating the symptoms of sore throat associated with a common cold. the study is designed to develop a treatment method against sore throat associated with a common cold which will have more advantages for patients than the methods that are currently available.


Eligibility criteria:
inclusion criteria: * male and female patients * onset of common cold within the past 5 days * current sore throat * confirmed presence of a tonsillo-pharyngitis exclusion criteria: * hypersensitivity to acetylsalicylic acid, salicylates, paracetamol, or any other nsaid * pregnant or lactating women * history or acute state of peptic ulceration or gastrointestinal bleeding * history of bleeding tendency * history of asthma * inability to breathe through the nose or a history of chronic mouth breathing * other exclusion criteria may apply

Keywords: sore throat
dietary diversity of young children during covid-19 outbreak: a longitudinal study

Conditions: Dietary Diversity

Summary: the 2019-2020 coronavirus pandemic has had far-reaching consequences beyond the spread of the disease. quarantine measures during a public health pandemic can be particularly detrimental to urban poor families and affect the dietary diversity and food security. this can disproportionately affect young children aged 6 and below, and severely impact those \<2 years. sudden unemployment may result in an unexpected reduction in income that will place pressure on daily budgets for food. children of families may not have access to foods of adequate diversity that will enable them to meet their macro and micronutrient requirements for growth and development, especially during the movement control order (mco). the study plans to monitor and evaluate dietary diversity in young children's food intake after the mco and use the collected information to direct targeted food aid to address observed macro- and micronutrient deficiencies among the urban vulnerable group.

children are the future to our society. the first thousand days of life, starting from conception till one's second birthday is a critical period of cognitive and physical development. it is the most sensitive period where brain development is most receptive to positive nutrition. any form of malnutrition, especially during this golden time frame, can lead to irreversible effects to growth, health, education and future career attainment to our potential leaders, which in turn can be a barrier to human development. the covid outbreak is a unique period in recent human history where drastic public health measures such as mco for an extended period of time has to be implemented nation-wide. these measures have untold severe consequences on the food security of the vulnerable urban group, in particular the young children whose brains require diverse micronutrients to support the rapid growth. these micronutrients can only be obtained from a daily diet that is equally diverse, especially from fresh vegetables and fruits which will be short in supplies. these perishable food items are not usually included in food aids, thus the child may have to subsist on staple-rich diet which are energy-dense but nutrient-poor. these dietary practices are associated with negative health outcomes. thus by monitoring dietary diversity of the children, we hope to better inform food aid organisations to consider the inclusion of healthier food options to prevent micronutrient deficiencies.

Eligibility criteria:
inclusion criteria: * all well-children aged between 6 months and 6 years exclusion criteria: * children with chronic illnesses

Keywords: dietary diversity micro-nutrient adequacy young children urban settings consumption of sugar sweetened foods and beverages
dental status of patients with severe mental illness

Conditions: Schizophrenia; Bipolar Disorder; PTSD; Depression

Summary: the investigators aim to assess the dental status of psychiatric patients suffering from severe mental illness (schizophrenia, bipolar disorder, ptsd, resistant depression).

patients will be assessed using the 1. dmft (decayed/missing/filled teeth) an epidemilogical assessment tool that assesses: 1. the number of teeth with current decay 2. the number of teeth missing 3. the number of teath treated in the past (filled) 2. cpi - community periodontal index an assessment of the gums 3. ohip-oral health impact profile a self-rating form to assess the social and functional afects of thier dental status

Eligibility criteria:
inclusion criteria: * all psychiatric patients suffering from schizophrenia, bipolar disorder, ptsd or resistant depression

Keywords: severe mental illness dental measures resistant depression
colonization of skin by m. luteus q24 probiotic

Conditions: Microbial Colonization

Summary: the purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic micrococcus luteus q24 (blis q24) to the face from a serum format in healthy adults.

this is a randomized double-blind baseline controlled pilot study with no crossover for the assessment of any changes to the microbial make-up of the skin (the local skin microbiome), detection of colonization by the probiotic bacterium (blis q24) on the skin and to evaluate the changes in skin quality parameters following topical application of probiotic in a serum format.

Eligibility criteria:
inclusion criteria: 1. in general good health 18 - 80 years of age. 2. practice good general body hygiene. exclusion criteria: 1. have a history of autoimmune disease or are immunocompromised (have a weakened immune system). 2. are on concurrent antibiotic therapy or regular antibiotic use within the last 1 week. 3. people with allergies or sensitivity to dairy. 4. people with an open wound on the blis q24 application sites.

Keywords: probiotics
follow up of patients with aortic aneurysm by dosage of circulant endothelial progenitor cells

Conditions: Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment

Summary: the study aims to investigate the existence of a reliable correlation between the progression of aortic diameters and blood levels of circulant endothelial progenitor cells cd34+ in patients with not surgical aortic aneurysms.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 or more. 2. patients diagnosed with a thoracic or abdominal aortic aneurysm with no indication for surgical treatment (diameters \> 30 mm but \< 50 mm). 3. patients accepting to sign a specific informed consent. exclusion criteria: 1. unstable coronary artery disease. 2. congenital heart disease. 3. any evolving infectious syndrome or viral infection (hiv, hbv or hcv). 4. any chronic inflammatory or autoimmune disease. 5. prior administration of g-csf; epo; gm-csf. 6. liver failure. 7. prior oncologic disease or ongoing cancer with a life expectancy \< 1 year. 8. dementia. 9. pregnancy. 10. patients aged \< 18.
zikalliance natural history study

Conditions: Zika Virus; Zika Virus Infection

Summary: study to enroll up to 1000 adult patients (\>18 years) presenting with febrile or rash illness of short duration (\<72h) in designated clinics in the state of sao paulo, brazil.

* study to enroll up to 1000 adult patients (\>18 years) presenting with febrile or rash illness of short duration (\<72h) in designated clinics in the state of sao paulo, brazil. * following enrolment (day 0), patients will be followed up at days 2-3, 7, 14, 21, 30, 90, 180 and 360 with clinical and biological procedures (blood and urine samples). * for patients with proven zika virus (zikv) infection, follow-up samples will include blood, saliva, urine and genital samples. * for non-zikv infected patients, follow-up samples will include serological monitoring at days 14, 30, 180 and 360, and for men, possible assessment of genital fluids at day 180. * all patients will be evaluated for impact on disability up to one year. household adult contacts of zikv patients will be invited for zikv evaluation including collection of blood and urine samples.

Eligibility criteria:
inclusion criteria: * rash or fever illness * within 72 hours of symptom onset exclusion criteria: * presence of symptoms or complications indicative of a bacterial infection

Keywords: chikv dengue chikungunya denv
effect of high-dose vitamin d3 in smokers and non-smokers with and without hiv

Conditions: HIV/AIDS; Vitamin D Deficiency; Smoker Lung

Summary: supplementation with vitamin d improves hiv+ macrophages phagocytosis in vitro. there is evidence to suggest that administering vitamin d can in fact improve immune function in individuals. the study will evaluate the impact of high dose vitamin d in hiv+ smokers' and hiv- smokers' in vivo. the primary goal is to improve innate immune host response to infection in patients already at high risk by virtue of hiv and smoking status.

tobacco smoke suppresses the lung's ability to fight infection. smoking is three times more prevalent in the hiv+ compared to hiv- patients. viral load was found to be significantly increased in hiv+ smokers compared to hiv+ non-smokers, suggesting that smoking enhances hiv-1 viral replication in macrophages, which contributes to disease progression. vitamin d deficiency has been associated with increased mortality in hiv+ persons, but there is limited research on how this is impacting the health of these highest risk patients and if aggressive repletion with vitamin d can improve overall health.the study team hypothesizes that vitamin d administration will increase pathogen clearance and improve innate immune function. the proposed pre and post interventional study is designed to characterize alveolar macrophage function and lung immunity according to tobacco use and hiv status, and determine the impact of high dose oral vitamin d3 on am phagocytic function and innate immunity.

Eligibility criteria:
inclusion criteria: * subjects living with hiv-1 infection who have been on anti-retroviral therapy (art) for a minimum of 12 months and are followed longitudinally for their hiv healthcare; * ability to give informed consent. exclusion criteria: * age \<18 yrs old; * known or possible pregnancy or breastfeeding; * documented history of cirrhosis or a direct bilirubin ≥ 2.0 mg/dl; * documentation of left ventricular ejection fraction \< 40% or myocardial infarction within the past 6 months; * end-stage renal disease requiring dialysis or a serum creatinine ≥ 2 mg/d; * spirometry with forced vital capacity (fvc) or forced expiratory volume (fev1)\< 70% of predicted value; * bleeding disorders such as thrombocytopenia or significant gastrointestinal bleeding within the past year; * inability to undergo bronchoscopy safely; * high risk behaviors without known hiv status.

Keywords: vitamin d3 pulmonary disease immunosuppression hiv smoking
stem cell migratory activity: prognostic marker in myocardial ischemia

Conditions: Myocardial Infarction

Summary: the present project aims to determine whether a deficit in migration of stem cells could be implicated in the failure to mount an adequate collateralization after myocardial infarction (mi) and thereby facilitate the development of post-ischemic heart failure (hf) and to dissect underlying molecular mechanisms. furthermore, the investigators wish to determine the predictive value of stem cell migration assay in patients with mi.

main objectives of the study: characterization of circulating cd133+ stem cells in a group of 170 patients with mi (mean post-mi follow up, 6 months): * counting total mononuclear cells and facs analysis of cd133 stem cells. * characterization of cd133+ stem cell biology: migratory assay, imaging of cytoskeleton, angiogenesis tests in vitro. * evaluation of migratory signalling, with specific focus on the pi3k/akt/enos system. assessment of the prognostic value of the stem cell migration assay. * relationship between cell biology tests on cd133+ cells and changes in circulating cytokines and pro-angiogenic factors after mi. * assessment of area at risk by ecg-synchronized single photon emission computed tomography (gated-spect) in subgroups with different patterns of stem cell migratory tests. * assessment of ventricular remodelling (echocardiography, nmr) in relation with patterns of stem cell migratory test. expected results: clarification of the implication of stem cell migratory deficit in post-ischemic hf. * identification of underlying mechanisms * identification of a cellular marker for prediction of patients at risk of hf. relevance to public health: * introduction of a biological test for the early diagnosis of post-mi hf * recognition of therapeutic targets for the rescue of stem cell migratory liabilities

Eligibility criteria:
inclusion criteria: * age \>= 18 years * thoracic pain lasting at least 20 min and st changes or left b block, not present in previous ecg. * mi confirmed by elevation of troponin i and ck-mb. * patients with killip ii e iii lv dysfunction will be included. exclusion criteria: * patients reporting thoracic pain 24 hours prior to hospitalization * hf symptoms resistant to therapy * haemoglobin\< 10 gr/dl * haemodynamic instability (systolic pressure \<90 mmhg after treatment) * alterations in haematopoiesys * concurrent neoplastic disease * no written informed consent or other conditions that affect patient's compliance to protocol.
a phase ii study of azd4877 (a novel anti-mitotic agent) in advanced bladder cancer

Conditions: Bladder Cancer; Transitional Cell Bladder Cancer; Urethra Cancer; Ureter Cancer; Renal Pelvis Cancer

Summary: the purpose of this phase ii study is to determine if azd4877, an experimental drug that is a novel anti-mitotic agent (eg5 or kinesin spindle protein inhibitor that interferes with tumor cell division leading to tumor growth), can reduce tumor sizes in patients with bladder cancer


Eligibility criteria:
inclusion criteria: * confirmed urothelial cancer (cancer of the bladder, renal pelvis, ureter, or urethra). * tumor, node, metastasis (tnm) stage iv urothelial cancer that can not be helped by curative surgery and/or curative radiotherapy * must have had a maximum of 2 prior chemotherapeutic regimens, one for unremovable and/or metastasized disease, and the other in the adjuvant or neo-adjuvant setting. * ambulatory and capable of all selfcare more than 50% of waking hours exclusion criteria: * prior treatment with investigational or standard anti-cancer agents, including radiotherapy, within 4 weeks prior to first dose of study medication; 6 weeks if prior systemic mitomycin, nitrosourea, or suramin. * inadequate bone marrow reserve * inadequate liver function in the presence of liver metastases * impaired renal function

Keywords: anti-mitotic eg5 inhibitor kinesin spindle protein inhibitor urothelial cancer bladder cancer renal pelvis cancer urethra cancer ureter cancer recurrent advanced stage iv