Kornimate/medical-research-clean huggingface dataset:
angiotensin ii blockade and inflammation in obesity

Conditions: Overweight; Obese; Prehypertension; Hypertension

Summary: overweight and obesity, which afflicts \~65% of the u.s. population and more than 1 billion people worldwide, increases the risk of developing hypertension. activation of the renin angiotensin system (ras) is an important mechanism by which obesity leads to hypertension. in addition to its vasoconstricting and sodium retaining actions, angiotensin ii also has potent pro-inflammatory actions including macrophage infiltration and expression of proinflammatory cytokines in target tissues. adipose tissue and skeletal muscle appear to be a key sites for the generation of proinflammatory cytokines. although angiotensin ii receptor blockade reduces inflammation in many tissues, the effects on adipose tissue and skeletal muscle in humans are not clear. importantly, the chronic low grade inflammatory state that accompanies obesity complicates hypertension by contributing to insulin resistance and accelerating cardiovascular disease. therefore, the general aim of the present proposal will be to determine the influence of angiotensin ii receptor blockade on adipose tissue and skeletal muscle inflammation and its relation to improvements in insulin sensitivity, if observed, in obese hypertensive humans. to address these aims, 44 obese (bmi\>30 kg/m2) hypertensive (bp\>140 systolic and/or 90 diastolic) individuals (age=50-65 years) will be randomized to receive 8 weeks of either the angiotensin ii receptor antagonist, olmesartan medoxomil, or no treatment in a crossover manner. subcutaneous adipose tissue and skeletal muscle biopsies will be obtained and insulin sensitivity (intravenous glucose tolerance tests) will be assessed at baseline and following 8 weeks of each intervention. a two week washout period will separate the interventions.


Eligibility criteria:
inclusion criteria: * 18-75 years of age * weight stable for previous 6 months (+2.0kg) * sedentary to recreationally active * willing to be randomized to treatment or placebo * verbal and written informed consent * approved for participation by medical director (jose rivero, m.d.) exclusion criteria: * blood pressure outside stated range * diabetes or taking diabetes medications * total cholesterol \>6.2 mmol/l; triglycerides \>4.5 mmol/l * past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, or hematological-oncological disease * evidence of renal insufficiency; gfr\< 60 ml/min\* * medications (including but not limited to antihypertensives, statins or other with anti-inflammatory actions) or antioxidant vitamins or supplements * known allergy or hypersensitivity to olmesartan or any of its components * pregnant or planning to become pregnant

Keywords: angiotensin ii obesity diabetes
noxipoint therapy versus standard physical therapy using electrical stimulation for chronic pain

Conditions: Shoulder Pain; Neck Pain

Summary: the purpose of this study is to validate the efficacy of noxipoint(tm) therapy on chronic pain, and compare it with standard physical therapy using electrical stimulation on patients with chronic pain. invented by dr. charlie koo at stanford university, noxipoint therapy is a specific procedure with precise location, duration and intensity of tens stimulation within the general fda guidelines. the therapy substantially relieves general muscular/tendon pain and persistently restores the muscle and tendon function. the surface locations of nociceptors at the free nerve ending (i.e., "noxipoints") are focused on in the stimulation therapy. multiple clinical uses of noxipoint therapy confirmed the consistent efficacy of such stimulation at noxipoints. an observational study of noxipoint therapy within the fda-approved use of tens demonstrated an encouraging 93% success rate in eliminating the chronic pain, such as frozen shoulder pain, within 2-3 sessions. it is an order-of-magnitude improvement over the non-specific application of tens and any other modalities in pain treatment. a unique neuro-immuno-signaling pathway that implicates the activation of adult stem cells, such as satellite cells in muscles, is implicated based on such a high success rate.

view http://paincurecenter.com/clinical_outcome.html for the observational study mentioned in the brief summary above. for more detailed cases, please view http://paincurecenter.com/uploads/nocipoint_therapy_clinical_study_w_o_id_2011-2012.pdf

Eligibility criteria:
inclusion criteria: * 18-64 years old male or female * having chronic pain (icd-9: 338.21, 338.29) in the neck/upper back (icd-9: 723.1), or the shoulder (icd-9: 719.41) * pain duration over 6 months, with at least one month of history of other therapy treatments (physical therapy, steroid injection, acupuncture, analgesic medicine, and/or massage therapy) exclusion criteria: * patients with bpi severity at its worst below 5 * traumatic injury from external impact force * pain caused by traumatic bone fractures * history of traumatic cervical injury * history of osteoporosis * pain related to systemic inflammatory conditions including polymyalgia rheumatic, systemic lupus erythematosis * signs of psychosomatic illness * severe rheumatoid arthritis undergoing active treatment including dmard biologics * steroid injection on pain site within 4 weeks * language and/or cognitive inability to complete the assessment questionnaires * previous tens for pain relief * for safety reasons, patients wearing cardiac pace makers, implanted defibrillator, or pregnant women

Keywords: cervical pain cervicalgia, cervicodynia neck ache neckache shoulder pain shoulder impingement syndrome
effect of oral supplementation with curcumin in patients with proteinuric diabetic kidney disease

Conditions: Proteinuria

Summary: the purpose of this study is to determine if the oral supplementation with curcumin reduces proteinuria, improves the redox and pro-inflammatory state in patients with chronic kidney disease associated to diabetes mellitus.

diabetic kidney disease (dkd) represents the fist cause of end-stage kidney disease in mexico and the world, and it is characterized by the presence of hyperfiltration, glomerular hypertrophy, tubular albuminuria and mesangial matrix expansion, mainly by the oxidative stress and the pro-inflammatory state. current treatments are limited on controlling proteinuria and delay progression of the disease, but even with an optimal management, a significant number of patient progress to end-stage renal disease. curcumin, found in the extracts of the rhizome of the plant curcuma longa l., has a wide spectrum of biological and pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-carcinogenic and anti-diabetic effects. it has the capacity to act directly with highly reactive oxygen species, induce the expression of various cytoprotective proteins through keap1/nrf2/are pathway and reducing inflammatory transcription factors such as nf-κb and tnf-α. curcumin could be an adjuvant treatment in the management of dkc due to his pleiotropic nature, low cost and few side effects.

Eligibility criteria:
inclusion criteria: * diagnosis of diabetes mellitus type 2 and proteinuric kidney disease with 1000 mg of more proteins in daily recollection * glomerular filtration rate between 15-60 ml/min/ 1.73 m2 calculated by ckd-epi * patients taking angiotensin ii receptor blocker or ace inhibitors exclusion criteria: * renal replacement therapy * autoimmune disease or malignancy * pregnancy * hepatic damage * congestive heart failure classification iii or iv (nyha) * history of organ transplantation * history of chemotherapy or immunosuppression within 2 years prior to screening

Keywords: redox and pro-inflammatory status
self-consciousness in dementia

Conditions: Alzheimer Disease; Fronto-temporal Lobar Dementia

Summary: the aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with alzheimer's disease (ad) and fronto-temporal lobar dementia (ftld), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study. we posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in ad and to social cognition in ftld.


Eligibility criteria:
inclusion criteria: * ad (mckhann et al, 1984 and dubois et al, 2007) or ftld (neary et al, 1998 or rascovsky et al, 2011) * mmse \> or = 18 * relative avaible exclusion criteria: * contraindication to mri * major depression * other central neurological condition
retrospective analysis of the epidemiological change and determinants of prognosis of talaromycosisof human immunodeficiency virus negative host in guangxi

Conditions: To Investigate the Characteristics and Prognostic Factors of T. Marneffei Infections and the Causes of Misdiagnosis; To Study the Recurrence Indicators and Establish a Therapeutic Effect Evaluation System of T. Marneffei Infections

Summary: through a multi-center large-sample retrospective study, the epidemiological changes of tsm in guangxi have been reviewed, its incidence trend was understood to attract the attention of clinicians; the multiple programs of antifungal therapy for hiv-negative host tsm were compared in terms of effect on clinical remission rate, effective rate, recurrence rate, mortality and toxic side effects on hiv-negative host tsm; their prognosis and recurrence indicators were clarified, and a therapeutic effect evaluation system was established, providing a standard treatment and diagnosis scheme for clinical practice; and simultaneously the positive rate of g and gm experiments in respect of tsm, aspergillus and other fungi was identified to provide tsm with biological diagnostic indicators. improve the level of understanding and diagnosis and treatment of hiv-negative tsm in the whole area. a comprehensive efficacy evaluation system and standard treatment program was established to provide a basis for standardized treatment of tsm in hiv-negative hosts. the observational indicators included: 2-week all-cause mortality; 24-week all-cause mortality; clinical improvement time; level of decrease of fungus in the blood culture medium two weeks before treatment; recurrence; appearance of adverse drug reaction at the level 3 and above.


Eligibility criteria:
inclusion criteria: * eligible patients were hiv-negative adults who had talaromycosis that was confirmed by either microscopy or culture. exclusion criteria: * patients were hiv-infected adults who had talaromycosis that was confirmed by either microscopy or culture.
an outpatient study of the efficacy, safety, and tolerability of pf-02545920 in the adjunctive treatment of sub-optimally controlled symptoms of schizophrenia

Conditions: Schizophrenia

Summary: this study aims to evaluate whether pf-02545920 is safe and effective in the treatment of sub-optimally controlled symptoms of schizophrenia during a 12-week outpatient treatment period. the study will use the positive and negative syndrome scale (panss) to measure change in symptoms for pf-02545920 from baseline compared to placebo.


Eligibility criteria:
inclusion criteria: * psychiatrically stable subjects with schizophrenia who have had a suboptimal response to current treatment * evidence of stable schizophrenia symptomatology greater than or equal to 3 months. * subjects must be on a stable medication treatment regimen greater than or equal to 2 months, including concomitant psychotropic medications. exclusion criteria: * history of seizures or of a condition with risk of seizures. * subjects with schizophrenia that have not responded at all to current treatment. * pregnant or nursing females, and females of child bearing potential.

Keywords: pf-02545920 schizophrenia outpatient safety efficacy suboptimal response
pain relief effect of angiopuncture for patients with postoperative pain

Conditions: Postoperative Pain

Summary: the study aimed to investigate the effectiveness of angiopuncture therapy in pain alleviation for postoperative pain patients. the study involved patients aged 20-65 with acute foot and ankle trauma and pain after surgery. physicians used handheld ultrasound doppler to measure perforators, puncture participants with a filiform needle, and monitor pain scores and heart rate data before and after acupuncture. the duration of therapy was 20 minutes per day for 72 hours, with pain measured using the numerical rating scale. the study aimed to compare the outcomes before and after angiopuncture.

in order to give therapeutic therapy, solid filiform needles are inserted into the skin during dry needling (dn), traditional acupuncture (ta), and western medical acupuncture (wma). dn is a treatment used to treat painful musculoskeletal illnesses, whereas ta and wma have a wider variety of indications, including musculoskeletal discomfort, gastrointestinal problems, and neurological concerns. while dn implants are used in trigger points, acupuncture is for acupoints. in addition, common methods include injections of painkillers, oral medications, and nerve blocks. angiopuncture therapy is being used for the first time as a method of pain management in this article. the aim was to investigate if skin perforating needling therapy could alleviate postoperative pain in patients. patients with recent foot and ankle surgery who have had acute foot and ankle injuries and pain. doctors measured three to four perforators at the proximal end of the trauma site using a handheld ultrasound doppler, punctured the perforators for 15 minutes with a filiform needle (size: 0.18mm gauge \* 25mm length), and then monitored the patient's pain level and heart rate data before and after acupuncture variety. if pain relief is possible, they'll do it. risks include becoming more painful. to create numbers, investigators employed an internet table generator. despite having just one group, investigators compared the results of angiopuncture before and after therapy lasts for 20 minutes per day for 72 hours. numeric rating scale (nrs) pain score at baseline: 6, 12, 24, 36, 48, 60, and 72 hours.

Eligibility criteria:
inclusion criteria: * aged 20-65 years * acute foot or ankle trauma * pain after foot or ankle surgery exclusion criteria: * have scars and deformities on the lower extremity surface * cannot cooperate with the locating method of angiopuncture * allergy to any material * pregnant women * breastfeeding women
role of propolis endodontic irrigant on post-operative pain

Conditions: Post-operative Pain; Symptomatic Irreversible Pulpitis

Summary: the goal of this clinical trial is to compare propolis and sodium hypochlorite as endodontic irrigants in patients presenting with symptomatic irreversible pulpitis. . the main question it aims to answer is: • if there is any analgesic effects of 20% propolis compared with 5.25% naocl on the intensity of post-operative pain in patients with symptomatic irreversible pulpitis using vas pain score. participants will undergo root canal treatment of their teeth using either 20% propolis solution or 5.25% naocl in their first visit of a multi-visit root canal treatment. researchers will compare 20% propolis and 5.25% naocl to see reduction in intensity of post-operative pain using visual analogue scale over 72 hour duration.

sodium hypochlorite as an endodontic irrigant, poses problems of toxicity. additionally, its unfavorable odor, taste, failure to remove the smear layer, and proteolytic effect have deleterious effects on the dentine, creating unfavorable structural and mechanical alterations . to get beyond naocl limits and adverse effects, it is necessary to look for a biocompatible, equally effective, and dentine friendly irrigant with greater patient acceptance in taste and odor. the literature lacks an in-vivo study that investigates the anti-inflammatory with analgesic characteristics of propolis on post-endodontic pain as an irrigant, in patients with symptomatic irreversible pulpitis. this research will endeavor to fill this gap in literature.

Eligibility criteria:
inclusion criteria: 1. asa-i and ii individuals who are between the ages of 18 and 60 years. 2. patients with mandibular and maxillary premolars who have been diagnosed with symptomatic irreversible pulpitis (with either a normal periapex or symptomatic apical periodontitis). 3. patients who score moderate to severe (4-10) on a preoperative visual analogue scale (vas=1-10) exclusion criteria: 1. patients suffering from severe pain because of traumatic occlusion. 2. teeth with extensive damage, calcified canals, periapical radiolucency, root resorption, and an open apex. 3. patients with compromised medical condition (asa-iii and above) 4. patients who are unable to communicate effectively in either urdu or english. 5. pregnant and lactating ladies 6. patients who are allergic to honey or bee pollen.

Keywords: propolis endodontic irrigant
effect of single incision versus three planned incisions to reduce pre-operative astigmatism after phacoemulsification.

Conditions: Astigmatism of Both Eyes

Summary: cataract surgery by phacoemulsification is the most commonly performed procedure in pakistan. cataract surgery aims for visual rehabilitation and freedom from all kinds of eyewear. pre-operative corneal astigmatism greater than 1.0 diopter is reported in 42% preoperatively and 58%postoperatively after implanting a monofocal intraocular lens(iol). visual acuity tended to worsen postoperatively with increased astigmatism4. different treatment modalities are used to reduce astigmatism, like toric iol. limbal relaxing incision, actuate keratotomy, intrastromal rings, lasik and femtosecond laser. most of these modalities are expensive, so they cannot be afforded by the patients as pakistan is a low-income country with a per capita income of us$1,562 (160th worldwide)

according to the 2020 estimate, 33·6 million adults aged 50 years and older were blind with cataracts as a leading cause (15·2 million cases). according to pakistan national blindness survey, cataract is the leading cause of blindness in pakistan. cataract surgery by phacoemulsification is the most commonly performed procedure in pakistan. cataract surgery aims for visual rehabilitation and freedom from all kinds of eyewear. pre-operative corneal astigmatism greater than 1.0 diopter is reported in 42% preoperatively and 58%postoperatively after implanting a mono-focal intraocular lens(iol). visual acuity tended to worsen postoperatively with increased astigmatism. different treatment modalities are used to reduce astigmatism, like toric iol. limbal relaxing incision, actuate keratotomy, intrastromal rings, lasik and femtosecond laser. most of these modalities are expensive, so they cannot be afforded by the patients as pakistan is a low-income country with a per capita income of us$1,562 (160th worldwide). our study aims to compare the results of phacoemulsification cataract surgery with a planned three (one 2.8 mm and two 2.0mm) on the or near to steep meridian incisions ( group a) with convention supero-temporal 2.8 mm clear corneal incision(group b) for the correction of postoperative astigmatism. we hypothesize that a planned three (one 2.8 mm and two 2.0mm) on the or near to steep meridian incisions ( group a) is better than conventional supero-temporal 2.8 mm clear corneal incision(group b) for the correction of postoperative astigmatism at a significant level of 0.05.

Eligibility criteria:
inclusion criteria: cataract patients aged between 50 and 80 years having 1.0 diopters (d) or greater of regular corneal astigmatism documented by keratometry. exclusion criteria: 1. previous ocular surgery. 2. previous ocular trauma. 3. pre-existing ocular disease. 4. high intraocular pressure (iop) 5. corneal opacity. 6. strabismus 7. amblyopia 8. diabetes mellitus 9. irregular astigmatism. -

Keywords: astigmatism. phacoemulsification, corneal incision
analysis of nutrition during chemoradiotherapy in patients with gastrointestinal cancer

Conditions: Nutritional Status; Gastrointestinal Cancer; Chemoradiotherapy

Summary: to assess the effectiveness of close and intense monitoring on nutritional status of gastrointestinal cancer patients during chemoradiotherapy (crt), 500 crt patients diagnosed with gastrointestinal system are going to be recruited into this prospective study. patient-generated subjective global assessment (pg-sga) scale and nutrition risk screening (nrs-2002) are used for nutritional assessment at the beginning and the end of crt; beside the nutritional parameters, quality of life questionnaire-core 30 (eortc qlq-c30) and gastric cancer module (qlq-sto22) are used to measure quality of life in patients with gastric cancer while eortc qlq-c30 and colorectal cancer-specific quality of life questionnaire (qlq-cr38) give assessment in colorectal cancer. the acute and late radiation toxicities were evaluated based on conmon terminology criteria (ctc v3.0) and the toxicity criteria of rtog/eortc, respectively. follow-ups every 3-6 months until three years after chemoradiotherapy are involved. response evaluation criteria in solid tumors (recist) guidelines are used for response assessment. the primary endpoints are 3-year local control, disease-free survival, distant metastasis and overall survival rate.


Eligibility criteria:
inclusion criteria for gastric cancer: * pathological confirmed adenocarcinoma * clinical stage t3-4 and/or n+ after radical surgery * without distance metastases * kps \>=70 * without previous radiotherapy * sign the inform consent inclusion criteria for rectal cancer: * pathological confirmed adenocarcinoma * clinical stage t3-4 and/or n+ * the distance from anal verge less than 12 cm * without distance metastases * kps \>=70 * without previous anti-cancer therapy * sign the inform consent exclusion criteria: * pregnancy or breast-feeding women * serious medical illness * baseline blood and biochemical indicators do not meet the following criteria: neutrophils≥1.5×10\^9/l, hb≥90g/l, plt≥100×10\^9/l, alt/ast ≤2.5 uln, cr≤ 1 uln * dpd deficiency