Kornimate/medical-research-clean huggingface dataset:
a pilot study of oxalate absorption in secondary hyperoxaluria

Conditions: Secondary Hyperoxaluria; Nephrolithiasis; Hyperoxaluria; Kidney Stones

Summary: identify individuals with greater absorption of oxalate based on increase in urinary oxalate excretion in response to a controlled oxalate-rich test meal.

this was a prospective 4-day study of oxalate absorption in subjects with secondary hyperoxaluria. subjects visited the research center three times for outpatient visits (screening, test day 3, day 4). subjects were instructed to follow a low-oxalate diet, consuming only study-specified food choices that had low or no oxalate and controlled calcium content days 1 through 4 (baseline period through the day 4 clinic visit) and, on test day 3, consumed an oxalate-rich test meal. subjects performed three 24-hour urine collections during screening, baseline day 2, and test day 3. test day 3 included the oxalate-rich test meal and the subject collected a 24-hour urine separated into 4 urine collection intervals. (pre-test meal, post-test meal to 4 hours, 4-6 hours post test meal and remaining time to complete 24 hours).

Eligibility criteria:
inclusion criteria: * males or non-pregnant and non-lactating females * history of hyperoxaluria secondary to a known underlying enteric disease (e.g., crohn's disease, bariatric surgery, and others) or without a known underlying cause (idiopathic), and kidney stones. * urinary oxalate ≥ 40 mg of oxalate/24 hr at screening. * if taking drugs for the prevention of stone disease, including pyridoxine, thiazides (chlorthalidone, hydrochlorothiazide, and indapamide), citrate supplements, and allopurinol, there must have been no changes in these medications for at least one month prior to screening and no changes are anticipated for the duration of the study. * able to understand and provide written informed consent. exclusion criteria: * under or over-collection on screening 24-hour urine collection (mg creatinine/kg body weight outside of gender-specific range). * estimated glomerular filtration rate (egfr) \<40 ml/minute/1.73 m\^2 or acute renal failure. * primary hyperoxaluria. * allergy, intolerance, or any other factors limiting ability to consume the study foods or adhere to the study meal schedule. * positive pregnancy test during screening. * clinically significant findings (including acute renal colic), an ongoing clinically significant illness requiring changes in management, or any planned medical/surgical procedure during the study. * malignancy undergoing active therapy; patients in remission on chronic suppressive or maintenance therapies are not excluded. * investigational compound within 30 days prior to screening. * investigator determined that the subject would not be able to adhere or to complete the study procedures , or could not discontinue vitamin c supplements, calcium supplements, or other medications that could interfere with oxalate absorption and/or excretion.

Keywords: urine oxalate nephrolithiasis kidney stones hyperoxaluria enteric hyperoxaluria urological diseases kidney diseases dietary oxalate idiopathic hyperoxaluria oxalate absorption
compensatory training to support brain healthy lifestyle changes in those at risk for alzheimer's disease

Conditions: Cognitive Symptom; Pre Senile Dementia; Alzheimer Disease

Summary: the researchers are trying to better understand if behavioral interventions can help improve memory compensation and engagement in healthy lifestyle behaviors in those with memory concerns but normal mental status exam.


Eligibility criteria:
inclusion criteria: * age 50 or older * a positive complaint or concern in response to two questions ('do you feel like your memory or other aspects of thinking are becoming worse?' and 'does this worry you?') * normal cognitive performance on the montreal cognitive assessment (adjusted for age and education) * self-reported independent function in daily life as measure by the lawson iadl scale (iadl=8) * english speaking * approval letter from a physician (due to the exercise component) exclusion criteria: * known neurological disorder with potential cognitive symptoms (a diagnosis of parkinson's disease, epilepsy, a history of significant tbi, etc.) * uncontrolled moderate or severe depression (e.g., ces-d \> 21).

Keywords: subjective cognitive complaint
evaluation of the triactiv proguard system during carotid artery stenting

Conditions: Carotid Stenosis

Summary: the purpose of this study is to evaluate the safety and efficacy of the triactiv® proguard™ system when used during a stent placement in a blockage within the carotid artery in patients considered to be at high risk for complications from surgical endarterectomy.

patients with certain anatomic or medical conditions have a greater risk of serious complications following carotid endarterectomy (a surgical procedure that removes blockages in the carotid artery). recently, these patients have been treated effectively with the implantation of a carotid stent (a metallic mesh tube). when implanting the carotid stent, physicians use devices called embolic protection devices to prevent particles from the blockage from flowing up to the brain. the triactiv® proguard™ system is an embolic protection device that uses a small balloon to temporarily stop blood flow within the diseased carotid artery while the stent is implanted. then, the triactiv® proguard™ system removes any particles that may have been released from the blockage during stent implantation before blood flow is restored. this study will evaluate the safety and efficacy of the triactiv® proguard™ system during carotid stent placement in patients who are considered to be at a high risk for complications from surgical endarterectomy.

Eligibility criteria:
inclusion criteria: * greater than 18 year of age * patient gives informed consent * less than 30mm stenosis in the common and/or internal carotid artery: at least a 50% stenosis if symptomatic or at least an 80% stenosis if asymptomatic * at least one medical or anatomic condition which makes the patient a high surgical risk. exclusion criteria: * stroke within 14 days * major stroke with significant residual effects * myocardial infarction within 72 hours * extensive atherosclerotic disease in the aortic arch or proximal common carotid artery * severe carotid artery tortuosity * total occlusion * presence of thrombus or heavy calcification in the carotid artery * pre-existing carotid artery dissection * any planned interventional or surgical procedures within 30 days * atrial fibrillation * creatinine \> 2 mg/dl * current participation in another investigational drug or device study

Keywords: carotid stenosis intracranial embolism carotid artery carotid stent embolic protection triactiv proguard system carotid angioplasty
lurasidone non-interventional study in schizophrenia patients

Conditions: Schizophrenia

Summary: the study is a multicentric, national, non-interventional, prospective, single arm study. the main goal of this study is to gather information about the effects, in a real-life setting, of lurasidone treatment on patient's reported outcomes, in terms of patient's treatment satisfaction, quality of life and functioning changes after 6 weeks from lurasidone treatment initiation in schizophrenia patients naïve to lurasidone.

important aim of the study is to investigate, aspects related to effectiveness, safety and tolerability at 3 months' lurasidone treatment in a routine practice in italian clinical settings. only patients with primary diagnosis of schizophrenia who are prescribed lurasidone was evaluated for inclusion in the study.

Eligibility criteria:
inclusion criteria: * adult (≥18 years) male or female subjects; * primary diagnosis of schizophrenia * patients not previously treated with lurasidone. the choice to initiate lurasidone treatment is independent of being included in the study; * patients legally capable of giving their written consent for participation in the study and for personal data processing. exclusion criteria: * concomitant participation in a clinical trial

Keywords: lurasidone patient's treatment satisfaction quality of life functioning changes schizophrenia
automated clinical reminders in the care of chronic kidney disease patients

Conditions: Chronic Kidney Disease

Summary: to determine whether the use of educational sessions and computerized clinical reminders can improve primary care doctors' delivery of care to ckd patients compared to educational sessions alone. hypothesis: clinical reminders will improve the care delivered to ckd patients

literature supports that most chronic kidney disease (ckd) patients are cared for by primary care physicians (pcp) without the help of a kidney specialist. many of these patients fail to achieve targeted outcomes and late referral to a nephrologist has been associated with an increased risk of death. automated computerized clinical reminders have been shown to improve physician compliance with recommended guidelines in other settings. aims: to determine if clinical reminders can help pcps decrease the rate of late referrals, improve urine albumin checks in ckd patients design: prospective randomized controlled, single-blinded study with additional historical control methods: two 20-minute teaching sessions aimed at all gim pcps in the upmc clinic followed by randomization of the eligible gim providers to receive automated clinical reminders (cr) for their ckd stage 3b-5 patients versus routine care. outcomes: using a database search, individuals with an egfr\<45ml/min/1.73m2 (not seen by a nephrologist) will have data collected on: pcp referral to a nephrologist, urinary albumin (or protein) quantification in the past year, pcp recognition of patients with egfr\<45ml/min, ace/arb usage.

Eligibility criteria:
inclusion criteria: * for pcps: all gim attending physicians with a weekly continuity clinic. * for patients: \>= 18 years-old with an egfr\<45ml/min/1.73m2 being seen in the upmc gim clinic by a faculty member during the 10-month intervention period exclusion criteria: * for pcps: imminent plans to leave the department * patients with a renal transplant, on any form of dialysis, or with a previous nephrology evaluation.

Keywords: chronic kidney disease clinical alerts late referral electronic medical record computerized clinical decision support systems (cdss)
is skin-to-skin care helpful for preterm infants and their mothers after birth?

Conditions: Moderate to Late Prematurity

Summary: to see if infant outcomes will improve when mothers are helped to hold their preterm infants skin-to-skin as soon as possible after birth and as often as possible and for as long as possible each time during the next five days.

a similar intervention was studied in a rct with fullterm infants but this was done with emphasis on close contact rather than skin-to-skin contact and lasted only the first 6 hours postbirth. this study was conducted by the same pi and funded by the national center for nursing research, nih 1990-1994. this research yielded numerous significant and beneficial differences. two pilot studies were done with healthy late preterm infants and mothers who planned to breastfeed. skin-to-skin contact began in the delivery room. the first pilot was a descriptive exploratory study with 10 mother-infant dyads done in cali, colombia; skin-to-skin began at birth and lasted through hour 6 when all dyads went to the postpartum ward. follow-up was through hospital discharge on the second day. all outcomes were positive. the second pilot was an rct done in the united states with a well balanced sample of 8 dyads, 4 in each group. mean observation time lasted 47 hours (medicaid required discharge time for the mothers) with skin-to-skin contact occurring 84% of the time. all outcomes favored the skin-to-skin group, for example 3.8 days to discharge home compared to 14.5 for the controls. follow-up was at one year and similarly positive. similar differences were hypothesized for the rct reported here in which the intervention was extended to the care of somewhat smaller and sicker preterm infants and lasted five days unless the infant was discharged sooner. the consent form was in layman terms, four pages long, and fulfilled all the requirements of the institutional review boards of the bolton school of nursing at case western reserve university, university hospitals case medical center and its general clinical research center, and kadlec medical center, richmond, wa.

Eligibility criteria:
inclusion criteria: mother and infant dyads infants: * singleton birth * 32 to 36 completed weeks * 5-minute apgar score of 6 or more * weighed 1300 to 3000 grams * no birth defects that would interfere with feeding * healthy enough to experience skin-to-skin contact with their mothers. mothers: * 18 or more years of age * spoke english * free of serious drug abuse * well enough to experience skin-to-skin contact with their infants with assistance if needed. exclusion criteria: infants: * too ill to be with their mothers * who have a condition that interferes with feeding. mothers: * who are too ill to care for their infant * are serious drug abusers.

Keywords: preterm infant skin-to-skin contact kangaroo care temperature behavioral state
inmobilization with compression bandage vs antebraquial splint in distal radius fractures

Conditions: Distal Radius Fractures; Internal Fixation; Complications, Mechanical

Summary: the aim of this study is to compare functional and radiological results in two groups of distal radius fractures treated with internal fixation with locking plate, and immobilized with antebrachial splint or compression bandage for 3 weeks.

the aim of the study is to compare functional and radiological results as well as to evaluate possible complications in distal radius fractures operated by open reduction and internal fixation with volar locking plate in two groups , one treated with immobilization using a forearm cast for 3 weeks and the other with immobilization using a compression bandage for 3 weeks, based on the hypothesis that compression bandage group could obtain better results in the short term, and none of the treatments is superior to the other after 3 or 6 months of evolution, as indicated by some reviewed studies.

Eligibility criteria:
inclusion criteria: * patients with type a, b, c fractures of ao classification of distal radius fractures * patents aged between 18 and 75 years, * patients operated on in the first 3 weeks after the trauma, and independent for the basic activities of daily living exclusion criteria: * patients with open fractures * patients with mental disorders (dementia, alcoholism, etc.), * patient dependent for basic activities of daily living * patients with fractures with severe articular and metaphyseal comminution and/or severe soft tissue injuries (type 2r3c3 ao), * patients with previous diseases or anatomical alterations in the injured wrist (previous fractures, rheumatoid arthritis, etc.).

Keywords: distal radius fractures volar plate internal fixation inmobilization
randomized controlled trial of a patient activation tool in pediatric appendicitis (antibiotics alone vs. appendectomy)

Conditions: Appendicitis; Children

Summary: the purpose of this study is to determine if a patient activation tool (pat) can improve decision making and patient centered outcomes in pediatric patients with appendicitis and their caregivers choosing between antibiotics alone and appendectomy.

the objective of this study is to to determine if a patient activation tool (pat) can improve decision making and patient centered outcomes in pediatric patients with appendicitis and their caregivers. hypothesis: a pat that activates patient-caregiver dyads will improve decision making and patient centered outcomes without compromising medical outcomes in children with appendicitis. specifically,the investigators expect the pat to improve decision self-efficacy and healthcare satisfaction without increasing disability days. methods/outcomes: the investigators will perform a randomized controlled trial comparing a pat to standard surgical consultation in patient-caregiver dyads choosing between either antibiotics alone or appendectomy for early appendicitis. the investigators will identify differences in various components of decision making and patient centered outcomes including caregiver decision self-efficacy, preparedness for decision making, decisional conflict, decision regret, caregiver activation, caregiver and child satisfaction with care and health related quality of life (hrqol), and caregiver and child knowledge. the investigators will also characterize the effects of a pat on medical outcomes from appendicitis in patients receiving the pat compared to those receiving standard surgical consultation alone. the investigators will determine differences in disability days, length of stay, readmission rates, and medical complications related to treatment choice (e.g. infection, recurrence).

Eligibility criteria:
inclusion criteria: * age : 7-17 years * ultrasound (us) or computed tomography (ct) confirmed early appendicitis: * us: hyperemia, \<1.1 cm in diameter, compressible or non-compressible, no abscess, no fecalith, no phlegmon * ct: hyperemia, fat stranding, \<1.1 cm in diameter, no abscess, no fecalith, no phlegmon * white blood cell count \< 18,000 * c-reactive protein\<4 (if obtained) * focal abdominal pain \</= 48 hours prior to receiving antibiotics exclusion criteria: * positive urine pregnancy test * other significant co-morbidities: * cardiovascular disease * malignancy * pulmonary disease * severe developmental delay

Keywords: appendicitis pediatric children non-operative antibiotics alone
abdominal rectus diastasis microscopy and rehabilitation (amire)

Conditions: Abdominal Rectus Diastasis

Summary: the goal of this randomised controlled trial is to evaluate the effect of a postoperative rehabilitation program after surgical correction of abdominal rectus diastasis. the main questions to answer are: 1. does structured postoperative abdominal exercise improve abdominal wall function in three months and twelve months after surgical correction of abdominal rectus diastasis 2. does connective tissue components differ in patients with abdominal rectus diastasis when compared to healthy individuals?

the investigators want to include patients in sweden that are eligible for surgical correction of their abdominal rectus diastasis. patients will be recruited at the surgical clinic at four hospitals in sweden. after being informed about the study and potential risks, all patient give written informed consent. randomisation is performed upon inclusion. all patients undergo surgery by plication of the linea alba. a blood sample is collected prior to the surgery. during the surgery the skin, connective tissue and rectus muscle are biopsied. on the first postoperative day, another blood sample is collected. follow up is conducted three and twelve months after surgery.

Eligibility criteria:
inclusion criteria: * diastasis \> 3 cm * at least 1 year since child birth * one year of steady weight after weightloss * bmi \< 30 * males with diastasis above and below umbilicus exclusion criteria: * new planned pregnancy * smoker * connective tissue disease * immunosuppressive treatment * umbilical hernia \> 2 cm

Keywords: randomised controlled trial rehabilitation
a study to determine the efficacy and safety of 122-0551 in subjects with plaque psoriasis

Conditions: Psoriasis; Plaque Psoriasis

Summary: corticosteroids are one of the mainstays of treatment for subjects with corticosteroid-responsive dermatoses such as psoriasis. this study has been designed to determine and compare the efficacy and safety of a formulation of 122-0551 versus the corresponding vehicle in subjects with stable plaque psoriasis after twice daily dosing for 14 consecutive days.


Eligibility criteria:
inclusion criteria: * subject has a clinical diagnosis of stable plaque psoriasis * subject has an ods score for the treatment area of 3 or 4 at study start exclusion criteria: * subject has spontaneously improving or rapidly deteriorating plaque psoriasis. * subject has guttate, pustular, erythrodermic or other non-plaque forms of psoriasis. * subject has used any phototherapy, photo-chemotherapy or systemic corticosteroid therapy within 30 days prior to study start * subject has used any systemic methotrexate, retinoids, cyclosporine or analogous products within 90 days prior to study start * subject has used any systemic biologic therapy for the treatment of psoriasis within 5 half-lives of the biologic prior to study start * subject had prolonged exposure to natural or artificial sources of ultraviolet radiation within 30 days prior to study start * subject has used topical body (excluding the scalp) psoriasis therapy including coal tar, anthralin, steroids, retinoids, vitamin d analogs (e.g., dovonex®) within 14 days prior to study start * subject has used emollients/moisturizers on areas to be treated within four hours prior to clinical evaluation at study start * subject is currently using lithium or plaquenil (hydroxychloroquine) * subject is currently using a beta-blocking medication (e.g., propranolol) or ace (e.g., lisinopril) inhibitor at a dose that has not been stabilized * subject is pregnant, lactating, or is planning to become pregnant during the study * subject is currently enrolled in an investigational drug or device study * subject has used an investigational drug or investigational device treatment within 30 days prior to study start * subject has been previously enrolled in this study and treated with a test article

Keywords: psoriasis plaque psoriasis 122-0551 steroid