Kornimate/medical-research-clean huggingface dataset:
over-night effect of dietary fiber on glucose metabolism and satiety

Conditions: Obesity; Metabolic Syndrome

Summary: the experimental model is a semi-acute, over-night, study where the purpose is to evaluate food factors related to colonially derived regulation and satiety in healthy subjects.


Eligibility criteria:
inclusion criteria: * normal fasting blood glucose * bmi 19-25 kg/m2 exclusion criteria: * gastrointestinal diseases * food allergies e.g. lactose-, gluten intolerance * metabolic disorder e.g. diabetes * tobacco/snuff users * no antibiotic or probiotic intake 2 weeks prior and during study. * vegetarians
curcumin (tumeric) in the treatment of irritable bowel syndrome: a randomized-controlled trial

Conditions: Irritable Bowel Syndrome

Summary: evidence exists to support low-grade inflammation as the inciting factor leading to visceral hypersensitivity and alteration in motility in irritable bowel syndrome.in the medical literature,there is ample in vitro and in vivo evidence supporting turmeric and its derivative curcumin as an antitumor, anti-inflammatory and antioxidant agent. we propose a randomized, placebo-controlled, double blinded, parallel treatment study evaluating the effects of turmeric on the symptoms of irritable bowel syndrome.


Eligibility criteria:
inclusion criteria: patients from the hospitals and clinics of the southern california permanente medical group who conform to the rome iii criteria and * age 18 years and above, * male or female, * able to give consent and follow the treatment plan and be able to answer surveys. * negative serum pregnancy test (females of childbearing potential only) and are willing to use an adequate method of contraception throughout the duration of the study. exclusion criteria: * any of the following: diabetes, hiv disease, use of anticoagulants or antiplatelet medication, abnormal coagulation or thrombocytopenia, biliary obstruction, inflammatory bowel, symptomatic gallstones, celiac disease, ongoing use of medications known to cause or exacerbate symptoms of ibs and chronic, daily users of ibs medications. * use of scheduled ibs medications for 4 weeks prior to and during the treatment period.

Keywords: irritable bowel syndrome constipation diarrhea gas bloating abdominal pain disturbance of defecation irritable colon
investigation of the effects of family-focused therapy in the early period of bipolar disorder and psychotic disorder

Conditions: Mental Disorder in Adolescence; Bipolar Disorder; Psychosis; Family Relations

Summary: family-focused therapy (fft) is a comprehensive therapy approach applied to individuals and their families. in the present study, the researchers aimed to investigate the effects of family-focused therapy (fft) in the early stages of psychotic disorder and bipolar disorder, regarding the psychiatric symptomatology, family communication skills, coping capacities, family burden and quality of life. a total of 34 young people diagnosed with bipolar disorder (bd) and 17 psychotic disorders (pd) will be included in the study.

in this study, the researcher's primary goal is to investigate the effects of family-focused therapy sessions on young people aged between 15 and 21. subjects were referred to an early intervention center for psychotic and bipolar disorders. the target population of the study consists of the patients in remission after the episode of the illness. therapy sessions will be conducted in line with the manual for "family focused therapy for high-risk adolescents and young adults for bipolar disorder or psychosis" revised by miklowitz et al. in 2018. fft will be completed in nine sessions. the first module of the program consists of three sessions, which consists of group psychoeducation for the patients and families. the second and third modules also include three sessions in each to teach communication skills and problem-solving skills in individual therapy sessions including patients and their families. sessions will be held once a week and completed in nine weeks. within the scope of this program, non-therapist clinicians will evaluate the participants' symptoms, psychosocial functioning, insight, and treatment compliance before and after the therapy sessions. there are only a few previous studies investigating the effects of family therapy in early stages of bipolar disorder and psychotic disorder. according to the literature, no prior study compares the effects of fft between bd and pd populations. this study is important in terms of developing effective strategies for management of psychosocial difficulties in early phases of bd and pds.

Eligibility criteria:
inclusion criteria: * not be in an active phase of the illness * able to comply with the interviews * the total score of the hamilton depression rating scale ≤ 21 points. * the total score of the young mania rating scale ≤ 14 points. * at least one family member with the capacity to read and write in turkish exclusion criteria: * neurological disorders and serious physical disease that affect cognitive functions * the symptoms due to substance use or a medical illness * autism spectrum disorder * comorbid alcohol and substance abuse (except nicotine) * co-morbid psychiatric disorders except disruptive behavior disorders and anxiety disorders

Keywords: family focused therapy bipolar disorder psychotic disorder child adolescent early intervention
hearing impairment in children: pupillometry and hearing thresholds assessment

Conditions: Hearing Impaired Children

Summary: the results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli. the investigators hypothesize that the perceived sounds will elicit increased pupil dilation compared to the non-perceived sounds and that the hearing threshold as measured with pure tone audiometry will correlate to the results in pupillometry test. the investigators hypothesize that the effect will be visible in all testing groups albeit the relative increase of pupil size with age. hypothesis confirmed, the investigators will develop a standardised procedure for the auditory signal detection using pupillometry. such a procedure could represent an important bridge between automatic and behavioral hearing tests. with a more precise test of auditory threshold of young children, post-operative monitoring and fitting of cochlear implants or hearing aids, and rehabilitation procedures, could be considerably more targeted and consequentially more efficient.


Eligibility criteria:
inclusion criteria: * normal or corrected-to-normal vision * no history of relevant neurological or psychiatric concomitant disease * age: 4-36 months * at least 1 months of more after initial fitting of the ci or hearing aid (only for aided subjects) exclusion criteria: * developmental disorders * unwillingness of the subject to participate further

Keywords: pupillometry hearing threshold pediatric cochlear implants
effect of superba krill on inflammation in patients with coronary artery disease

Conditions: Stable Atherosclerotic Coronary Disease

Summary: atherosclerotic coronary heart disease is a condition thought to involve low-grade inflammation. several reports, clinical and epidemiological, have demonstrated that intake of fish oil may be beneficial in attenuating the inflammatory process. still, however, there are lacking data in respect to whether differences in composition of various marine oils may influence the inflammatory status differently. the hypothesis of the current study is that extract from the antarctic krill (euphausia superba) is better than traditional fish oils when compared head-to-head with balanced composition of omega 3 content on inflammatory status.


Eligibility criteria:
inclusion criteria: * age: 18-80 years * sex: male and female * stable atherosclerotic coronary heart disease (heart attack \>3 months ago or objectified angina pectoris). * no hospitalization for heart disease last 3 months. exclusion criteria: * unstable heart disease. * heart failure nyha class iii and iv. * previous valve and/or aortic surgery * significant concomitant disease (i.e. diseases with known inflammatory activation - e.g. various autoimmune diseases, chronic infections, significant acute infections three weeks before or during the study, connective tissue disease, arthritis, chronic pulmonary disease or serious liver- or kidney-disease). * simultaneous involvement in other clinical studies involving intervention. * planned operation or other invasive procedures (e.g. pci etc.) during the study period.

Keywords: fish oil krill cad
oral zinc supplementation to enhance botulinum neurotoxin response

Conditions: Dystonia, Focal

Summary: botulinum neurotoxin (bont) is injected into muscles for treatment of dystonia. bonts are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc. the study hypothesis is that a large enough fraction of unselected dystonia patients receiving bont injection have suboptimal zinc concentration in their tissues, and will experience improved response to bont if the injection is preceded by oral zinc supplementation (ozs). ozs consists of 50 mg of zinc acetate oral tablet each day for 7 days before injection. this is a double blind placebo controlled cross-over study, randomized order placebo and ozs, in patients at a neurology clinic on stable dose of bont.


Eligibility criteria:
inclusion criteria: * patients of the pi * age 18-80 * male or female * with an approved indication for bont such as dystonia or hemifacial spasm * have received either two or three bont injection cycles within the prior 8 months * prior two injection cycles length differed by no more than 2 weeks * prior two injection cycles used same brand of bont and similar dose within 15% exclusion criteria: * concommitant use of penicillamine or cisplatin
a study comparing adapalene gel 0.1% and to differin gel in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: to demonstrate therapeutic equivalence and safety of adapalene gel 0.1% (taro pharmaceuticals u.s.a., inc.) and differin® gel (adapalene gel 0.1%, galderma) in the treatment of acne vulgaris.

a multi-center, double-blind, randomized, placebo controlled, parallel-group study, adapalene gel 0.1% (taro pharmaceuticals u.s.a, inc.) and to differin® gel (adapalene 0.1%, galderma) and both active treatments to a placebo control in the treatment of acne vulgaris

Eligibility criteria:
inclusion criteria: * healthy male or non pregnant female aged ≥ 12 and ≤ 40 years with a clinical diagnosis of acne vulgaris. * subjects who are 18 years of age or older (up to the age of 40) must have provided irb approved written informed consent. subjects ages 12 to 17 years of age inclusive must have provided irb approved written assent; * subjects must have a definite clinical diagnosis of acne vulgaris of severity grade 2, 3, or 4 as per the investigator's global assessment (iga) exclusion criteria: * female subjects who are pregnant, nursing or planning to become pregnant during study participation * subjects with a history of hypersensitivity or allergy to tretinoin, retinoids, or any of the study medication ingredients. * subjects with the presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris (e.g., on the face: rosacea, dermatitis, psoriasis, squamous cell carcinoma, eczema, acneiform eruptions caused by medications, steroid acne, steroid folliculitis, or bacterial folliculitis).
a new dual task test method for football players

Conditions: Sports Physical Therapy; Multi-Tasking Behavior; ACL Injury; Kinesiophobia

Summary: multitasking (dual task) is a measurement method to evaluate cognitive ability to execute multiple functions at the same time. to perform this test, while participant/patient performing a main skill (for example, walking), a cognitive skill is added (for example, counting 7 backwards from 100) to measure how much the completion performance of the activity is affected. frequently used multitasking trainings are known as counting back from 100 and asking mathematical equations during a physical skill. multitasking skill is rarely used in sports-related training, and it is generally used in the form of counting 7 backwards from 100, counting months and counting 5-letter words while walking over obstacles. however, multitasking training methods described and applied in the literature are not specific to football skills. for this reason, limited tests defined and applied in other clinical and sportive fields may not be sufficient in football players who perform activities that require high performance. therefore, aim of this study is to develop a dual-task assessment method, which includes the cognitive loads experienced by football players during training and matches, and also covers the basic skills of football. as a result of this study, a football-specific dual-task test will be created and the capacity of the athletes will be measured by applying this test to healthy athletes. also, this test will be conducted on football players with recent knee injury history, who wish to return to sport, and to evaluate their dual-task capacity and to correlate it with kinesiophobia and other performance tests


Eligibility criteria:
inclusion criteria: * attending regularly to the trainings * being a professional football player exclusion criteria: * having any neurological disorders

Keywords: soccer dual task performance rehabilitation return to sport
deep friction massage in children with spastic cerebral palsy

Conditions: Spastic Cerebral Palsy (sCP)

Summary: the aim of this clinical trial is to determine whether deep friction massage and stretching reduce muscle contraction in the calf muscle. the primary questions it seeks to answer are: * does deep friction massage or stretching reduce muscle contraction? * does deep friction massage or stretching improve walking? * does deep friction massage or stretching increase ankle joint range of motion? participants: participants will undergo either deep friction massage or stretching exercises for 10 minutes, three days a week, over a period of six weeks.


Eligibility criteria:
inclusion criteria: * a diagnosis of spastic diplegic or hemiparetic cp * aged between 3 and 18 years * classified as level i, ii, or iii according to the gross motor function classification system (gmfcs) * possessing sufficient cognitive function to cooperate. exclusion criteria: * botulinum toxin (bont) injections to the lower extremity muscles within the last six months * undergoing any surgery such as muscle lengthening or joint contracture within the last six months * non-participation in two consecutive exercise sessions * experiencing illnesses such as infections or musculoskeletal injuries during the study period.
acupuncture for breast cancer related lymphedema

Conditions: Breast Cancer Lymphedema

Summary: the purpose of this study is to evaluate the clinical efficacy of acupuncture on chronic upper limb lymphedema in patients with breast cancer surgery


Eligibility criteria:
inclusion criteria: * at least 6 months after breast cancer surgery and presents with persistent breast cancer related upper extremity lymphedema for at least 3 months. * stage ii lymphedema according to the 2016 consensus by the international society of lymphology. * women aged 18 to 80 years * out-patients * estimated life expectancy \> 6 months * upper extremity lymphedema is defined a more than 10% volume difference between the affected and unaffected arms exclusion criteria: * bilateral breast cancer related lymphedema * tumor metastasis or recurrent patient * patients who is undergoing chemotherapy, radiation therapy or targeted therapy * taking diuretic * upper extremity lymphedema reached more than 80% volume difference between the affected and unaffected arms * history of primary lymphedema * a diagnosis of severe heart, liver, kidney or hematologic disease * edema caused by upper extremity disability or other conditions such as heart failure, kidney disease or malnutrition * have hypoproteinemia * inflammation, scar, or trauma at the site of operation, or other active skin infections * unable to self-care, had a history of psychological disorders, or unable to communicate * received lymphedema treatment within the past 1 month * pregnancy or breastfeeding * the presence of electronic medical device implants * deny to sign the informed written consent, or unwilling to conform to randomization * participation in other clinical trials during the study period
medipixel xa-assisted pci in coronary artery disease

Conditions: Percutaneous Coronary Intervention (PCI); Coronary Arterial Disease (CAD)

Summary: this prospective, multicenter, single-arm, interventional study evaluates the effectiveness and safety of medipixel xa-assisted percutaneous coronary intervention (mpxa-pci) in patients with coronary artery disease (cad). the study aims to assess procedural success rates and clinical outcomes associated with the novel mpxa-assisted pci strategy in a real-world clinical setting. a total of 830 patients with de novo coronary lesions eligible for drug-eluting stent (des) implantation will be enrolled. all participants will undergo mpxa-assisted lesion assessment to optimize balloon and stent selection. the primary outcome is target vessel failure (tvf) at 12 months, defined as a composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularization. secondary outcomes include procedural success, angiographic results, and periprocedural complications. this study will provide evidence regarding the clinical applicability and safety of artificial intelligence-assisted quantitative coronary analysis (ai-qca) technology for optimizing pci procedures.


Eligibility criteria:
inclusion criteria: * silent ischemia, stable or unstable angina, or myocardial infarction * de novo coronary lesion eligible for des implantation * lesions analyzable by mpxa exclusion criteria: * comorbidity with a life expectancy \<12 months * intolerant of antithrombotic therapy * significant anemia, thrombocytopenia, or leucopenia * history of major hemorrhage (intracranial, gastrointestinal, and so on) * chronic total occlusion lesion * left main lesion * severe calcification needing rotational atherectomy * lesions not analyzable by mpxa

Keywords: artificial intelligence quantitative coronary analysis medipixel mpxa
re-examination of tumor material and re-evaluation of patient data from patients treated with neo-adjuvant therapy

Conditions: Breast Cancer

Summary: this is a prospective examination of ribonucleic acid (rna) extracted from tumor material of breast cancer patients treated with a neo-adjuvant therapy. the rna will be analysed for expression of estrogen receptor (er 1), progesterone receptor (pgr), her2 and ki-67 with mammatyper™. according to the determined values for the individual parameters at least 4 subtypes can be distinguished to date * luminal a-type * luminal b-type * her2-type * triple-negative-type as non-clinical endpoint, the agreement of new subtyping with immunohistochemical methods will be evaluated. as clinical objective, the 5 year distant metastasis free survival (dmfs) and overall survival (os) will be reevaluated according to the new subtyping.

tumor material collected from patients who received neoadjuvant therapy either with four cycles of doxorubicin 60 mg/m² plus pemetrexed 500 mg/m² on day 1 every 21 days followed by four cycles of docetaxel 100 mg/m² on day 1 every 21 days or four cycles of doxorubicin 60 mg/m² plus cyclophosphamide 600 mg/m² on day 1 every 21 days followed by four cycles of docetaxel 100 mg/m² on day 1 every 21 days will be re-analyzed with the mammatyper kit. the kit is an in-vitro molecular diagnostic test for molecular subtyping of breast cancers into luminal a \& b, her2 and triple negative. it allows quantitative detection of the rna expression status of the genes for estrogen receptor (esr1), pgr, her2 and ki-67 on the basis of their mrna present in the samples. this prospective diagnostic study will investigate the subtyping-results of the mammatyper™ analysis and will compare them to the subtyping of the former immunohistochemical analysis performed. based on the mammatyper™-subtypes the efficiency of the therapy regimen and the outcome will be re-evaluated from the patient data.

Eligibility criteria:
inclusion criteria: * women aged 18-70 years with histologically confirmed primary invasive breast cancer stages t2-t4/n0-n2/m0 with a tumor size of ≥ 2 cm as measured by ultrasound * the patient provides a written informed consent for analysis of tumor material exclusion criteria: * prior anticancer therapy with an anthracycline or other prior antitumor therapy for breast cancer * inflammatory or exulcerating breast cancer * a second primary malignancy \[except carcinoma in situ (cis) of the cervix or adequately treated nonmelanoma skin cancer\] unless diagnosed and treated ≥ 5 years ago with no evidence of recurrence * any serious concomitant systemic disorder

Keywords: diagnostic study analysis of estrogen receptor progesterone receptor human epidermal growth factor receptor 2 ki-67
traditional chinese medicine suan tsao jen tang and tian-wang-bu-xin dan in patients with primary insomnia.

Conditions: Insomnia

Summary: keywords： traditional chinese medicine, herbs, clinical trial, insomnia, quality of life, suan-zao-ren tang, tian-wang-bu-xin-dan

title： traditional chinese medicine suan tsao jen tang and tian-wang-bu-xin dan in patients with primary insomnia. a multi-center, double blind, placebo controlled clinical trial. (first year of two-years' project) design: randomized, placebo-controlled trial comprising 3 arms: szrt, placebo, twbxd. setting: the chung shan medical university affiliated hospital and the taipei city hospital. methods: a total of 128 subjects 20-80 years of age with a history of insomnia at least 1 month were recruited randomly assigned to szrt (n = 48), placebo (n =32), twbxd (n =48) and were instructed to take 6 gm 2 times per day of szrt, twbxd or placebo for a period of 4 weeks. the primary outcome measures were the mean component scores of the pittsburgh sleep quality index (psqi). secondary outcome parameter were the global score on the world health organization quality of life questionnaire - taiwan brief version, drugs consumption counts, sleep diary and safety profiles by structures questionnaires.

Eligibility criteria:
inclusion criteria: * insomnia disorders in patients 20-80 years of age, the pittsburgh sleep assessment scale (psqi)\> 6 points. * no insomnia caused by other diseases. for example: mental illness (depression, etc.), sleep apnea, heart disease (acute myocardial infarction, heart rate is not the whole), hypertension, diabetes, cancer and so on. * there are more than a week (including) three times to be more than 30 minutes to fall asleep and sleep less than six hours, there is a continuous months. * test subjects had to really understand the nature of this study, and participants signed consent. exclusion criteria: * before participating in this study, three months, had a major accident or wheel graveyard shift or jet lag problems (such as a long flight). * any insomnia caused by other diseases. for example: mental illness (depression, etc.), sleep apnea, heart disease (acute myocardial infarction), poorly controlled hypertension (\> 140 / 90mmhg), poorly controlled diabetes (hba1c\> 7%), cancer, digestive ulcers (undergoing treatment). * 2 weeks into the experiment of taking melatonin or melatonin agonist, acetylcholine, glutamate, serotonin, norepinephrine, gaba, histamine, adenosine, prostaglandins and other drugs. * if patients sleep disorders arise from nighttime urinary frequency. pregnant or breastfeeding person. * patients unable to read and fill out the questionnaire by themselves this study.

Keywords: suan-zao-ren tang tian-wang-bu-xin-dan traditional chinese medicine herbs quality of life