Kornimate/medical-research-clean huggingface dataset:
vaccine response in patient with sepsis

Conditions: Sepsis

Summary: vaccination is established as an effective means of individual and collective protection. hospitalization is an opportunity not to be missed to catch up on vaccinations in certain fragile patients. patients hospitalized in infectious diseases are generally treated for an acute or chronic infection that can modulate their immunity and therefore their vaccine response. current vaccine immunogenicity data in immunocompromised patients support a lower percentage of responders than observed in immunocompetent patients. there is little data to assess the vaccine response (vr) in patients treated for an infection (bacteremia, pneumonia, urinary tract infection, etc.). in order to respond to this problem, the investigators have chosen to evaluate the vaccine response to prevenar 13 (pcv13), a conjugate vaccine recommended as a prime-boost since 2013, which must be followed by a vaccination at 2 months with pneumovax, an unconjugated vaccine of 23 valences. anti-pneumococcal vaccine coverage in frail people (immunocompromised, heart failure, respiratory failure, kidney failure, diabetics) remains low and is estimated at less than 10% in 2011, while the bacteria is responsible for severe invasive infections. in total, the investigators would like to study the vaccine response at 1 month of vaccination with prevenar 13 in patients hospitalized in infectious disease for sepsis, in order to demonstrate the benefit of vaccination per hospitalization.


Eligibility criteria:
inclusion criteria for all patients: * age ≥ 18 years old and \<80 years old * planned length of hospital stay in infectious disease department ≥ 48 hours * indication for vaccination against pneumococcus according to the 2013 has recommendations * vaccination planned as part of the usual care * patient hospitalized for sepsis meeting the sepsis criteria according to the latest consensus of 2016 or sirs ≥ 2 with documented infection * patient having signed the free and informed consent form * subject affiliated to social security inclusion criteria for patients positive to covid-19: * pcr sars-cov 2 \> 0 within 28 days priodi admission and/or, * scanner compatible with sars-cov 2 infection. exclusion criteria: * pregnant or breastfeeding women, * vulnerable people * pneumococcal vaccination according to the prime-boost scheme already carried out less than 5 years old * pneumovax vaccination \<1 year * known hypersensitivity to the active substances or to any of the excipients or to diphtheria toxoid. * igg level\> 1 µg / ml among more than 75% of serotypes at inclusion * withdrawal of consent
internet-delivered postpartum anxiety prevention

Conditions: Postpartum Disorder

Summary: postpartum anxiety disorders are the most prevalent postpartum psychiatric conditions. up to 16% of mothers experience postpartum anxiety or related disorders, such as ocd. with respect to the investigator's own community, this means that up to 3,313 women in west virginia may struggle with postpartum anxiety or ocd. left untreated, perinatal anxiety and ocd are associated with numerous adverse outcomes, such as maternal depression, preterm birth, impaired fetal development, low birthweight, difficulty breastfeeding, anxiety in children, and interference with parent-infant bonding. critically, anxiety is a risk factor for cardiovascular disease and substance use disorders, both significant west virginia health disparities. thus, there is a critical need to develop effective and scalable prevention programs to address postpartum anxiety and ocd. the purpose of this proposed community-engaged study is to develop and test the feasibility, usability, and acceptability of an internet-delivered postpartum anxiety and ocd prevention program, called "preventing postpartum onset distress", or p-pod.


Eligibility criteria:
inclusion criteria: * female * aged 18 or older * pregnant with first child * married or living with a partner * state trait anxiety inventory-trait total ≥ 44 and/or obsessive beliefs questionnaire-44 total ≥ 139 exclusion criteria: * past or current anxiety disorders * past or current ocd * past or current psychotic disorders * past or current bipolar disorders * past or current substance use disorders.
dynamic gait index in hemiplegic cerebral palsy

Conditions: Cerebral Palsy; Hemiplegic Cerebral Palsy; Gait Disorders, Neurologic

Summary: the purpose of this study is to assess validity and reliability of dynamic gait index (dgi) in patients with unilateral spastic cerebral palsy

cerebral palsy (cp) is a childhood onset, lifelong neurological disorder, attributed to non-progressive injury of the fetal or immature brain. it causes movement deterioration and activity limitation. in cp patients increase in slow walking speed, shorter step length, and longer duration in the double support phase are common. such gait changes are thought to reflect the unbalanced walking pattern seen in these children. although children with cp are well known to have poor balance and high fall incidence, little effort has been made to quantify the dynamic walking stability of these children. the dynamic gait index (dgi) is a performance-based tool developed by shumway-cook and woollacott to quantitatively measure dynamic balance capabilities. it also evaluates the individual's ability to modify gait in response to changing gait task requirements. despite it's widespread use in the elderly population, dgi has not yet been investigated in children with neurological conditions. considering that it takes a little time to apply the test, it may be advantageous for children in terms of simplicity and ease of administration. in this study the investigators aim to validate and assess interrater and test - retest reliabilities of turkish version of dynamic gait index in children with unilateral, spastic cerebral palsy.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of spastic unilateral cerebral palsy * age between 4 - 16 * able to stand and walk without any orthosis or special equipment * volunteer to study exclusion criteria: * being unable to walk * having cognitive disorder * history of orthopedic surgery or any intervention for spasticity within the previous 12 months * uncontrolled epilepsy * visual conditions that prevent full participation to assessments * lower extremity contracture that may affect assessments
fluid restriction after stapled hemorrhoidopexy

Conditions: Fluid Restriction

Summary: background: conventional hemorrhoidectomy leads to a high urinary retention rate and fluid restriction is commonly recommended to minimize complications. however, the need for postoperative fluid restriction among patients who have undergone stapled hemorrhoidopexy is unclear. we aimed to determine whether fluid restriction after stapled hemorrhoidopexy with/without partial external hemorrhoidectomy could reduce urinary retention and postoperative pain. patients and methods: in this prospective, double-blinded, randomized controlled trial, we enrolled patients who had grade iii or iv hemorrhoids and underwent stapled hemorrhoidopexy with/without partial external hemorrhoidectomy; 250 ml/12 h of sterile 0.9% saline was administered to the fluid restriction group after the operation, and 1000 ml/12 h was given to the non-fluid-restriction group. we focused on the need for fluid restriction after stapled hemorrhoidopexy.


Eligibility criteria:
inclusion criteria: * gr. iii-iv hemorrhoids paitents exclusion criteria: * age\ 80 * allergy to nsaid or opoids * impaired renal function * pregnant or breast feeding

Keywords: stapled hemorrhoidopexy fluid restriction urinary retention
visar augmented reality navigation of ventriculostomy

Conditions: Obstructive Hydrocephalus; Subarachnoid Hemorrhage; Brain Trauma

Summary: this study is intended to evaluate the feasibility of using visar augmented reality surgical navigation during placement of an external ventricular drain (evd). the investigators are interested in confirming the design of the visar headset is compatible with this bedside procedure.

a secondary objective of this study is to compare the accuracy of freehand evd navigation, the current standard of care, with visar augmented reality surgical navigation. the intent is to demonstrate the advantages to the patient by the use/application of this next generation navigation technology.

Eligibility criteria:
inclusion criteria: * adult patients, 18 years and older, determined to need an external ventricular drain (evd) or ventriculostomy catheter by the attending neurosurgeon secondary to a variety of pathologies, including obstructive hydrocephalus, trauma and subarachnoid hemorrhage. exclusion criteria: * patients less than 18 years of age. * pregnant women. * prisoners.
effect of music therapy on patients undergoing intravitreal injections

Conditions: Intravitreal Injections; Patient Satisfaction; Patient Anxiety

Summary: multiple studies in various specialties, including ophthalmology, are reported in the literature that show that playing music during a procedure (dubbed music therapy) increases patient satisfaction and may reduce patient anxiety and stress levels. there is no study in the literature that assesses the effects of listening to music in patients undergoing intravitreal injections. this study aims to assess whether listening to music improves patient satisfaction or reduces their anxiety levels in subjects undergoing intravitreal injections.


Eligibility criteria:
inclusion criteria: * those patients at least 18 years old already scheduled for intravitreal injections. exclusion criteria: * those patients not interested in participating in the study or not capable of filling out the questionnaire secondary to limited mental capability. * non- english speaking subjects will be excluded from the study. * those patients that participated in the study will not be allowed to participate a second time.
evaluation of lycopene in the treatment of erosive oral lichen planus

Conditions: Erosive Lichen Planus

Summary: the aim of this study was to evaluate the effect of oral lycopene and systemic steroids in the treatment of erosive oral lichen planus and compare between the two therapeutic modalities.

twenty erosive lichen planus patients were recruited and randomly assigned in one of two groups, the test (lycopene) and control (corticosteroids) group.

Eligibility criteria:
inclusion criteria: * erosive oral lichen planus patients with severe and extensive painful erythematous, erosive and/ or ulcerative lesions who are in need for systemic corticosteroid therapy exclusion criteria: * pregnant females and smokers. * patients suggestive of having lichenoid contact/drug reactions. * patients suffering from any systemic disease as diabetes, liver disease, renal disease, any other autoimmune or collagen disease. * lesions showing histological features of dysplasia. * patients with skin lichen planus lesions.
myeloid-derived supressor cells in cardiac surgery patients

Conditions: Insufficiency; Cardiac, Complicating Surgery; Systemic Inflammatory Response Syndrome

Summary: pro- and anti-inflammatory response during the formation of the critical state develops at the same time. because of its balanced or unbalanced systemic inflammation can be either aborted or able to lead to multiple organ failure. with regard to sepsis, systemic inflammatory response characteristics are well understood, is not achieved in respect of the "sterile" inflammation. extracorporeal circulation is a clinical model of systemic inflammatory response due to non-physiological activation of tissue factor in the extracorporeal perfusion, the use of non-pulsatile circulation mode, intentional / unintentional hypothermia, bacterial translocation from the gastrointestinal tract and perfusion deficit. we have proved that the monocytes demonstrate suppressor function, which can be a predictor of complications from cardiac surgery patients. the most important component of the formation of multiple organ failure (mof) in critically ill patients is immunosuppression. during the study of experimental and clinical tumor growth process scientists has provided a new population of immature myeloid cells (myeloid suppressor cells or suppressor cells of myeloid origin, mdsc). most of the works have been devoted to the role of mdsc in the development of tumors, where it has been clearly shown that this cell population has an undoubted effect of immune suppression. however, recent studies show that the role of mdsc is not limited to cancer process, but extends to chronic or acute inflammation. the aim of this study is to determine the role of mdsc in the development of immune suppression and complications after heart surgery carried out under cardiopulmonary bypass.

the use of mec systems can be useful to prevent the mdsc activation after cardiac surgery. the procedures to modulate the cytokines concentration can be useful to prevent the mdsc activation after cardiac surgery.

Eligibility criteria:
inclusion criteria: 1. the patients with ischemia heart disease and/or valvular heart disease, 2. signed inform consent, 3. cabg and/or valve replacement/plastic procedures. exclusion criteria: 1) congenital heart disease.

Keywords: immune suppression, inflammatory response, cardiac surgery
a prospective study to evaluate the effect of systemic adjuvant therapy on the cognitive function of breast cancer patients

Conditions: Breast Cancer

Summary: the primary objective of this prospective pilot study is to examine the variation of cognitive function at various time-points in stage i-iii breast cancer patients who have undergone or are undergoing adjuvant systemic therapy (chemotherapy and/or anti-hormonal therapy) and compare this to a group of healthy controls to evaluate if there is a difference. all randomized patients and their respective controls would be required to complete the computerized neuropsychological assessment cantab at certain time-points.these patients and controls would also be given on the same day as cantab testing, a set of questionnaires to evaluate subjective factors such as anxiety, depression, fatigue or menopausal symptoms which may also have an effect on cognition. subjective assessment of cognitive function will rely on self-reporting by study participants using a validated questionnaire.the potential risks to subjects are minimal, as this is a study without any intervention regarding the medical management of patients. by participating in this study, subjects will be helping in the aim of determining if there is cognitive impairment post-therapy, and if so, how prevalent is this phenomenon, when it arises and how it changes with time. this will consequentially play an important role with regard to patient knowledge. furthermore, if chemotherapy is shown to be associated with cognitive impairment, further studies can be carried out to determine the exact pathophysiology behind this phenomenon. this will allow for sensitive and timely detection of cognitive dysfunction in patients who have received chemotherapy and/or anti-hormonal therapy, and subsequently open the avenue for research in preventing or alleviating this phenomenon. this is crucial in improving patients' quality of life, social and occupational performance. the investigators hypothesis is that systemic adjuvant therapy in the form of chemotherapy and/or anti-hormonal therapy given to primary breast cancer patients can cause cognitive impairment.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed stage i-iii breast carcinoma 2. \< 65 years old 3. female exclusion criteria: 1. previous exposure to chemotherapy/anti-hormonal therapy for any other malignancy 2. previous neoadjuvant therapy for breast cancer 3. concomitant second primary in-situ or invasive carcinoma or previous history of carcinoma/carcinoma-in-situ 4. known disease or injury to the central nervous system (including neurodegenerative diseases, epilepsy), severe visual or auditory disorders 5. motor weakness due to any cause which makes using a touchscreen computer difficult 6. known background of depression, anxiety disorders or other neurobehavioural conditions 7. ongoing use of tranquilisers or anti-depressants 8. previous neuropsychological testing 9. current or previous history of alcohol or drug dependent

Keywords: healthy women consisting of a friend or relative of the patient
pnf method for those working in special education

Conditions: Caregiver Burden

Summary: the aim of the study was to examine the acute effect of self-proprioceptive neuromuscular facilitation (pnf) stretching on chest mobility, posterior muscle chain mobility and respiratory functions in caregivers of children with developmental delays. in the study: 1. does self-pnf stretching have an effect on chest mobility and posterior muscle chain mobility in caregivers of children with developmental delay? 2. does self-pnf stretching have an effect on respiratory functions in caregivers of children with developmental delays? the questions were answered.

a cross-over randomized controlled study was designed with 30 caregivers of children with developmental disabilities. using the online randomization method, caregivers were first assigned to either the pnf stretching group or the static stretching group. before and after the application, rib cage mobility was evaluated by chest circumference measurement, hamstring muscle mobility by popliteal angle measurement, lumbar region mobility by schober test, posterior muscle chain mobility by finger-floor distance measurement test, and respiratory functions by respiratory function test. the caregiver, who entered a 1-day cleansing period, repeated the evaluation and technique application with the stretching technique that was not applied the next day.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * no history of infection or flare in the previous 4 weeks * participants who have not been included in another clinical trial in the last month * those whose knee flexion angle is 15 degrees and above in the hamstring muscle shortness test exclusion criteria: * vestibular disorders, participants with known balance impairment within the past three months due to concussion * those with musculoskeletal system problems in their lower extremities * those who had lower extremity and thorax surgery in the last year * those with metabolic diseases

Keywords: maintenance burden pnf technique rehabilitation worker
planned visual education about skin cancer

Conditions: Skin Neoplasm

Summary: this study aimed to evaluate the effect of planned visual education based on the health belief model on university students' attitudes and beliefs toward skin cancer. the planned visual education based in health belief model has possitive effects on univestiy students' attitudes and beliefs toward skin cancer.

this study aimed to evaluate the effect of planned visual education based on the health belief model on university students' attitudes and beliefs toward skin cancer. planned as a cluster-randomized controlled experimental study conducted on two groups (n=116). the study was carried out in faculty of economics and administrative sciences (feas) and hasan ferdi turgutlu faculty of technology (hftft) from the faculties of manisa celal bayar university (mcbu) between february-semptember 2019. among seven departments in feas and four departments in the hftft, simple random sampling was used to draw lots again. the department of econometrics from the feas was assigned as the intervation groups (n=58) and mechatronics engineering from hftft was assigned as the control group (n=58). data were collected using the student introduction form and the health belief model scale in skin cancer.

Eligibility criteria:
inclusion criteria: * who registered and continuing department courses * who agreed to participate in the study * who had formal education * who been second year students exclusion criteria: * registration and absence of the student in the department courses * refusal to participate in the study

Keywords: health belief model health attitudes university students skin cancer
improving quality of life of prostate cancer survivors with androgen deficiency

Conditions: Prostate Cancer

Summary: the purpose of this phase ii trial is to determine the efficacy and safety of testosterone replacement therapy (trt) in improving the symptoms of androgen deficiency and health-related quality of life in men with prostate cancer who have undergone radical prostatectomy.

the overall objective is to conduct a proof-of-concept double-blind, placebo-controlled, parallel group, randomized trial to determine the efficacy and safety of testosterone replacement therapy (trt) in improving the symptoms of androgen deficiency (sexual symptoms, low energy, and physical dysfunction) and overall health-related quality of life in men with prostate cancer who have undergone radical prostatectomy for organ-localized disease (pt2,n0,m0), gleason score \ 2 years after radical prostatectomy, and who have androgen deficiency.

Eligibility criteria:
inclusion criteria: men with prostate cancer, who have stage pt2, n0, m0 lesions (confined to the gland); combined gleason score of 7 (3+4 elements) or less; preoperative psa less than 10 ng/ml; stable and undetectable psa level (psa less than 0.1 ng/ml using an assay that has a functional sensitivity of 0.1 ng/ml) for at least two years after radical prostatectomy. * age: 40 years and older * presence of symptoms related to sexual dysfunction, fatigue/low vitality, or physical dysfunction. * an average of two fasting, early morning serum testosterone levels, measured by lc-ms/ms, less than 275 mg/dl and/or free testosterone by equilibrium dialysis \ 300 ng/dl. * ability and willingness to provide informed consent exclusion criteria: * men who have undergone radiation therapy * men receiving androgen deprivation therapy will be excluded. * hemoglobin \ 16.5 g/dl * severe untreated sleep apnea * allergy to sesame oil * uncontrolled heart failure * myocardial infarction, acute coronary syndrome, revascularization surgery, or stroke within 3 months * serum creatinine \>2.5 mg/dl; alt 3x upper limit of normal; * hemoglobin a1c \>7.5% or diabetes requiring insulin therapy * body mass index (bmi) \>40 kg/m2 * untreated depression. subjects with depression who have been on stable anti-depressant medication, or undergoing cbt for more than three months are eligible. * men with axis i psychiatric disorder, such as schizophrenia, will be excluded. * subjects who have used the following medications within the past 6 months: testosterone, dhea, estrogens, gnrh analogs, antiandrogens, spironolactone, ketoconazole, rhgh, megestrol acetate, prednisone 20 mg daily or equivalent doses of other glucocorticoids for more than two weeks