Kornimate/medical-research-clean huggingface dataset:
heat disinfection of hd water treatment system in hemodialysis patients

Conditions: All Cause Mortality

Summary: hemodialysis (hd) may lead to increase inflammatory response through a number of mechanisms. hd-related inflammation is mainly due to underlying kidney disease, coexisting comorbidities, uremia per se, dialyzer membrane biocompatibility and contaminated dialysis fluid. accordingly, hd patients are chronically exposed to microinflammation as a result of blood-membrane interaction and dialysis fluid contamination. among these factors, biofilm formation and contaminated dialysis fluid are closely related to enhanced immune activation in hd patients. furthermore, only dialysis fluid quality is controllable and preventable. therefore, to reduce the cardiovascular (cv) events and improve the outcome, it prompts us to conduct a prospective randomized controlled study to explore whether heat disinfection link in hd water treatment system can effectively prevent biofilm formation, to ensure the dialysis fluid purity, and subsequently to improve the patient outcome, in terms of cv events and mortality.

inflammation is common in individuals with both chronic kidney disease (ckd) and hemodialysis (hd). hd may lead to increased inflammatory response through a number of mechanisms; some of these factors also result in pro-inflammatory cytokine release and consequently cause the overlap between anemia, accelerated atherosclerosis and inflammation. hd-related inflammation is mainly due to underlying kidney disease, coexisting comorbidities, uremia per se, dialyzer membrane biocompatibility and contaminated dialysis fluid. accordingly, hd patients are chronically exposed to microinflammation as a result of blood-membrane interaction and dialysis fluid contamination. among these factors, biofilm formation and contaminated dialysis fluid are closely related to enhanced immune activation in hd patients. furthermore, only dialysis fluid quality is controllable and preventable. therefore, to correct rhuepo poor response and reduce the cardiovascular (cv) events, it prompts us to conduct a prospective randomized controlled study to explore as to whether heat disinfection link in hd water treatment system can effectively prevent biofilm formation, to ensure the dialysis fluid purity, and subsequently to improve the patient outcome, in terms of cv events and mortality.

Eligibility criteria:
inclusion criteria: * age over 20 years and duration of hd over 3 months, and clinically stable exclusion criteria: * patients with acute infection, malignancy, active autoimmune disease, gi bleeding or blood loss; systemic inflammatory disease; life expectancy less than 3 months, and unwilling to participate in this study.

Keywords: biofilm formation proinflammatory cytokines high sensitive c reactive protein cardiovascular events overall mortality hemodialysis
aerobic vs neuromuscular exercise for knee oa

Conditions: Knee Osteoarthritis

Summary: the study aims to compare the effects of an education and high intensity interval training program (ehiit) with the widely used neuromuscular exercise and education program (nemex-e) on knee oa symptoms and risk factors for cardiovascular disease in people with knee oa and at least one risk factor for developement of cardiovascular disease. the main research questions the study aims to answer are: * is the ehiit program better than the nemex-e program for reducing the risk of cardiovascular disease? * are the two programs equally good at providing improvement in knee symptoms?


Eligibility criteria:
inclusion criteria: * age ≥18- years * diagnosis of tibiofemoral knee oa according to the american college of rheumatology criteria * radiographically confirmed diagnosis of tibiofemoral oa based on radiographs not older than 6 months. * average knee pain level ≥ 4 (0=no pain and 10=worst pain) over the past week (7 days) * at least one of following risk factors for development of cardiovascular disease: * body mass index ≥ 30 kg/m2 * hypertension (or in treatment of): systolic ≥ 135 and/or diastolic ≥ 85 mm hg * elevated hba1c (or in treatment of): ≥ 130.7 mg/dl (44 mmol/mol) * elevated triglycerides (or in treatment of): ≥ 150 mg/dl (1.7 mmol/l) * elevated cholesterol (or in treatment of) (low density lipides, ldl): ldl ≥ 54 mg/dl (3.0 mmol/l) exclusion criteria: * contraindication to exercise (e.g., resting systolic blood pressure \> 200 or diastolic blood pressure \> 115, acute or reoccurring chest pain) * unstable body weight the last 3 months (gain/loss outside +/- 5 kg) * planned weight loss (non-pharmacological, pharmacological, and surgical) during study participation * known current cancer * major cardiovascular event within the last 5 years * insulin dependent type 1 or type 2 diabetes * psoriatic, rheumatoid, or gouty arthritis disease * generalized pain syndromes such as fibromyalgia * lumbar or cervical nerve root compression syndromes * scheduled surgery during study participation * treatment with biological medication * impairments that prevent performance in high intensity aerobic exercise * current or planned participation in other health research intervention studies * pregnant/considering pregnancy * any other condition or impairment that, in the opinion of the investigator, makes a potential participant unsuitable for participation or which obstruct participation, such as a large knee joint effusion, uncontrolled diabetes/hypertension, psychiatric or cognitive disorders, language barriers, or opiate dependency.
comparison of dreem to clinical psg for sleep monitoring in apnea patients

Conditions: Sleep; Sleep Apnea

Summary: this study aims to evaluate the accuracy of apnea detection and automated sleep analysis by the dreem dry-eeg headband and deep learning algorithm in comparison to the consensus of 5 sleep technologists' manual scoring of a gold-standard clinical polysomnogram (psg) record in adults during a physician-referred overnight sleep study due to suspicion of sleep-disordered breathing.

the study will enroll up to 70 adults who are referred to the stanford sleep medicine center by their physician for an overnight polysomnographic sleep study due to suspicion of sleep-disordered breathing, with the aim of collecting 60 usable data sets (i.e., eligible subjects with high-quality psg and dreem recordings). upon arrival to the clinic, patients provide informed consent, are interviewed to determine eligibility, and complete a detailed demographic, medical, health, sleep, and lifestyle questionnaire (alliance sleep questionnaire; asq). after the asq, participants are fitted with the psg and the dreem headband by the sleep technologist. during the psg sleep study, the dreem headband records eeg, pulse, oxygen saturation (so2), movement, and respiratory rate. many participants may undergo a split-night study with a continuous positive airway pressure (cpap) device during their participation, as deemed necessary by the clinical staff pursuant to the sleep study. the psg data from the first 30 eligible participants will be manually scored by 5 sleep technologists. these manually-scored psg data files (referred to as the training dataset) will be synchronized with dreem data files from the same night and the synchronized files will be used to train dreem's deep learning algorithms. following training, the algorithms will be deployed to automatically score the final 30 participants' dreem datasets (testing dataset). finally, psg records for the second 30 participants will be provided to the sponsor and manually scored by 5 sleep technologists. the manual scoring results will be compared to the dreem automatic analysis to determine the accuracy of dreem's apnea-hypopnea index (ahi) severity detection and sleep staging algorithms.

Eligibility criteria:
inclusion criteria: * 18-70 years of age * capable of providing informed consent * suspicion of sleep breathing disorder (both diagnostic and split-night studies) exclusion criteria: * concomitant diagnosis of a sleep disorder other than sleep apnea syndrome or insomnia * morbid obesity (bmi \> 39) * use of benzodiazepines, nonbenzodiazepine (z-drugs), or gammahydroxybutyrate (ghb) the day/night of the study * concomitant diagnosis of cardiopulmonary or neurological comorbidities (such as heart failure, copd, neurodegenerative conditions)

Keywords: automated sleep staging automated apnea detection
best hypnotic drug choice for rapid sequence induction in the operating room

Conditions: Rapid Sequence Induction

Summary: the best hypnotic choice to optimize the balance between good intubation condition quality and hemodynamic stability during rsi performed in the operating theatre remained to be investigated. therefore, a randomized study evaluating the efficacy of propofol, ketamine, and a combination of both is appropriate. so, we designed the hypnotiks randomized controlled study to investigate the efficacy of these hypnotic drugs in patients undergoing rsi in the operating theatre. the primary endpoint will be the successful tracheal intubation at the first attempt without major arterial hypotension event.


Eligibility criteria:
inclusion criteria: * age between 18 - 80 years' old * female\* and male * ≥ 1 risk factor of aspiration of gastric contents defined as * preoperative fasting period of less than 6 hours, * occlusive syndrome, functional ileus, vomiting episode within the last 12 hours, * orthopaedic trauma within the last 12 hours, * medical history of symptomatic gastroesophageal reflux or hiatus, hernia or gastroparesis or dysautonomia or gastroesophageal surgery with sphincter dysfunction) * patient requiring orotracheal intubation during general anaesthesia in the operating room. * patient or his/her next of kin written informed consent or emergency procedure exclusion criteria: * predicted impossible tracheal intubation (≥ 1 of the following criteria: patient with known intubation complications, mallampati score iv, thyromental distance ≤ 4.0 cm, mouth opening \< 3 cm, sternomental distance \< 12.5 cm, significant modification of the airway due to congenital, cancer, trauma or burning lesions (non-exhaustive list)) \[30\] * preoperative arterial hypotension (map \< 65 mmhg or under catecholamine) * preoperative respiratory distress syndrome (spo2 \< 90% in room air) * contraindications to the use of ketamine and/or propofol and/or nmb: * allergy to the active substance or to one of the excipients or to soy or peanuts, * porphyria * intracranial hypertension * uncontrolled arterial hypertension (systolic arterial pressure \> 180 mmhg) * personal or family history of known malignant hyperthermia, congenital muscular dystrophy, myasthenia, a known congenital deficit in plasma pseudocholinesterase * pregnancy or breast-feeding woman * patients under court protection or guardianship * absence of insurance covering health costs

Keywords: rapid sequence induction full stomach patient hypotension propofol ketamine ketofol general anesthesia
effects of occlusion training on hockey players

Conditions: Sports Physical Therapy

Summary: occlusion training is simply a way of restricting blood flow in the veins of a working muscle in hopes to kick-start some larger gains in muscle size and strength. occlusion training performed during hockey training on speed and physical performance of hockey players. this training also known as blood flow restriction training, can be defined as the training of muscles while limiting blood flow to the muscles and typically done by performing high intensity, low weight, lifts while using some form of tourniquet or band to limit blood supply to limb being trained.

this study will be a randomized controlled trial and total sample size of both groups will be 18 and calculated through non-probability sampling technique and the players will allocate into two groups, control group and experimental group, per group sample size is 9. each will perform the session for occlusion training. before and after training sessions players completed a series of test to assess their speed and physical performance. occlusion training will help us providing unique beneficial training mode for promoting muscle hypertrophy. in control group players will perform general exercises session and in experimental sessions players will perform with occlusion training which is blood flow resistance training (bfr training shoulder, leg extension, bicep curls, kaatsu) 4 times a week for 4 weeks with 5 sets of 5 repetitions and then assessed pre-training and post-training values with assessment tools bench press, leg squat, leg power, maximum sprint time and pull-ups performed at 70% of 1-repetition maximum. this training will also improve and increase muscular strength in players.

Eligibility criteria:
inclusion criteria: * male * athletes with age group of 19-30 years of age. * all players who had a minimum of two years of resistance training experience exclusion criteria: * systemic issues with orthopedic issue, fractures, neuromuscular issue, cardiac issues. * players having history of prior surgery.

Keywords: field hockey, muscle hypertrophy, occlusion training, power
ergometer training in patients with osa

Conditions: Obstructive Sleep Apnea

Summary: patients with suspected osa (obstructive sleep apnoea syndrome) are asked to use a standard bike ergometer which is additionally equipped with a system to gather training data and the ability to send daily training time to an internet server to which the physician has access. training time of two groups is compared. group one is not motivated while group two benefits from telephone feedback when training time declines. it is presumed that training time increases with better information and response to training behaviour.


Eligibility criteria:
inclusion criteria: 1. suspected osa 2. capable of giving consent exclusion criteria: 1. symptomatic cardial infarction 2. decompensated cardiac insufficiency 3. hemodynamically effective cardiac arrhythmias 4. hemodynamically significant vitia (heart disease) 5. insufficiently regulated arterial hypertension 6. global respiratory insufficiency 7. significant partial insufficiency (pao2 \<50mmhg or sao2 \< 80% at rest) 8. state after decompensation of cor pulmonale 9. right ventricular strain at pulmonary hypertension at rest (pulmonary arterial pressure \> 20 mmhg) 10. severe osteoporosis 11. higher degree of lung functional restriction: fev1 \ 60% of nominal value after bronchospasmolysis 12. working performance on ergometer \< 50% 13. unstable bronchial asthma 14. exacerbated copd 15. heavily overweight (bmi \>40 or weight \>140kg)

Keywords: ergometer training motivation telemonitoring sleep apnea
probiotic sport study

Conditions: Oxidative Stress; Inflammation; Endotoxemia

Summary: we investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise. hypotheses (h1): * supplementation has an influence on oxidative stress parameters before and post exercise * supplementation has an influence on parameters of endotoxemia and inflammation before and post exercise * strenuous exercise has an influence on parameters of oxidative stress, inflammation and endotoxemia


Eligibility criteria:
inclusion criteria: * trained men * 30 - 45 years * non-smokers * 4wk wash out of all dietary supplements exclusion criteria: * untrained people (vo2max \< 55 ml x kg-1) * female * all people not matching this age group * smokers * all men taking dietary supplements * all men that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant st-decrease or increase, blood pressure \> 240 mmhg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..) * all people that are not adjudged as "healthy"

Keywords: oxidative stress inflammation endotoxemia strenuous exercise
progrip mesh repair vs lichtenstein operation

Conditions: Inguinal Hernia

Summary: the purpose of this trial is to compare clinical outcomes and to analyze cost-effectiveness following self-gripping, sutureless parietex progrip mesh to traditional lichtenstein operation with lightweight polypropylene mesh.

single-center patient-blinded randomized clinical trial comparing self-gripping mesh (parietex progrip) and standard lichtenstein method using lightweight polypropylene mesh. patients will be randomly allocated to the lichtenstein operation (l) and progrip repair (r) group. patients will be followed for one year. the primary outcome measure are: postoperative pain using the visual analog scale (vas) and numeric rating scale (nrs). assessments will be made before the surgery, in the day of discharge, 1, 6 and 12 months postoperatively. secondary endpoints: recurrence rate, post-operative complications (short and long-term), foreign body sensation, incidence of surgical-site injury, costs, hospital stay, surgery duration, safety and patients satisfaction.

Eligibility criteria:
inclusion criteria: * all patients with primary inguinal hernia * signed consent exclusion criteria: * recurrent hernia * emergency procedure * patient not willing to participate

Keywords: inguinal hernia mesh lichtenstein hernia repair selfgripping mesh
rheumatoid arthritis real-world cohort study in china (realsa)

Conditions: Rheumatoid Arthritis

Summary: an ongoing long-term cohort study is conducted in the sun yat-sen memorial hospital of sun yat-sen university, that is dedicated to recruiting ra patients, to identify the development of clinical, neuroimaging, and biochemical biomarkers for the diagnosis and prognosis of ra, especially for those with sarcopenia/myopenia to improve the prognosis of ra, this study includes the following objectives: 1. construct a useful database to explore the secular dynamic progress of ra, especially the difference between early and lately ra, as well as to improve our understanding of the life-course factors affecting the process that will facilitate future research activities. 2. identify the potential markers (clinical, biomedical and imaging) affecting/predicting the development process of sarcopenia/myopenia or other prognosis in ra patients. 3. develop the related multi-modal prediction models with clinical, biomedical and imaging variables to improve the diagnosis and prognosis of ra.


Eligibility criteria:
inclusion criteria: * patients aged 18 years or older and diagnosed with ra according to 1987 acr or 2010 acr / eular classification criteria exclusion criteria: * patients diagnosis with tumors without control, or aids * patients with serious disease in cardiovascular, kidney and blood and endocrine system; and 3) history of schizophrenia or epilepsy
percutaneous unilateral biportal endoscopy versus uniportal endoscopy for lumbar spinal stenosis: study protocol

Conditions: Lumbar Spinal Stenosis

Summary: a prospective study aimed to compare the efficacy and safety of unilateral biportal endoscopic (ube) technique and uniportal endoscopic (ue) technique for treating patients with lumbar spinal stenosis (lss).


Eligibility criteria:
inclusion criteria: * age range: 50-80 years * diagnosed with lss of 1-2 response levels * the predominant manifestation is neurogenic intermittent claudication, and conservative treatment has been ineffective for at least 3 months * degenerative lumbar spondylolisthesis of less than i degree or without spine instability * patients agree to participate in the study and are willing to complete the follow-up exclusion criteria: * isthmic lumbar spondylolisthesis or degenerative lumbar spondylolisthesis of greater than i degree * instability at the response level * prior surgical history at the response level * scoliosis with cobb angle \&gt;20 degrees * other conditions affecting the lumbar spine (infection, tumor, fracture, neurological diseases, and others) * patients with medical disorders who are unable to tolerate surgery
a study to understand how effective is tofacitinib when compared to other advanced treatments in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to learn how different types of medicines may improve disease activity in people with rheumatoid arthritis (ra). ra is a kind of joint disease that causes pain and swelling. the study will look at data from a large, us-based group of ra patients who have taken the below medicines: * tofacitinib * abatacept * tocilizumab or sarilumab the study will compare clinical disease activity scores of patients on the different medicines taken. the study will also decide whether some patient traits or disease factors play a role in how medicines may improve disease activity.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years on the cohort entry date. 2. diagnosed with rheumatoid arthritis (ra) at any time prior to cohort entry date: 1. at least two ra diagnosis codes at least 30 days apart, each coming from an encounter with a rheumatologist; 2. at least one inpatient visit with a ra diagnosis code; 3. at least two outpatient records with a ra diagnosis code at least 30 days apart and within a year, regardless of physician specialty; or 4. at least one outpatient record with an ra diagnosis and a prescription or fill for a disease modifying anti-rheumatic drug (dmard) from a specified list and does not have any of the non-ra conditions for which those drugs may also be prescribed. 3. initiation of specified biologic or targeted synthetic molecule dmards of interest for treatment of ra (ie, tofacitinib, etanercept, adalimumab, certolizumab, golimumab, infliximab, abatacept, tocilizumab, or sarilumab). 4. at least 180 days of baseline data available prior to and including the cohort entry date. 5. at least one clinical disease activity index (cdai) score in 45 days prior to and including the cohort entry date (baseline). exclusion criteria: 1. patients diagnosed with concomitant indications for tofacitinib \[psoriatic arthritis (psa), uc, and polyarticular course juvenile idiopathic arthritis (pcjia)\] at any time prior to cohort entry date, determined by at least two (2) diagnosis codes at least 30 days apart and prior to baseline. 2. patients with \>1 b/tsdmard (ie, tofacitinib, etanercept, adalimumab, certolizumab, golimumab, infliximab, abatacept tocilizumab, or sarilumab) prescribed on index date.