Kornimate/medical-research-clean huggingface dataset:
evaluation of minimal invasive thyroidectomy

Conditions: Thyroid; Goiter

Summary: the goals of minimally invasive approaches are better cosmetic results with small neck scar, decreasing postoperative pain, and shortening of hospital stay periods without postoperative complications. the concept of surgical invasiveness cannot be limited to the length and site of the skin incision; it must be extended to all structures dissected during the procedure. conventional thyroidectomy without raising subplatysmal flaps has proven to be effective in reducing postoperative pain and seroma

minimal invasive flapless thyroidectomy (mift) is a new technique that can be used in replacement of the conventional method of thyroidectomy for the management of selected cases of benign thyroid disorders. this work aims to evaluate the feasibility, safety, and efficacy of minimal invasive flapless thyroidectomy (mift) in the management of thyroid disease as regards postoperative pain, cosmesis, operative time, and other postoperative complications in comparison to conventional thyroidectomy technique.

Eligibility criteria:
inclusion criteria: * the limited size of the gland: volume less than 50 mm by ultrasound assessment. no evidence of retro-sternal extension. benign nature of the disease proved by fnac. exclusion criteria: * the patients who have one or more of the following criteria: 1. the size of the gland is more than 50 mm by ultrasound assessment. 2. patients with retro-sternal goitre. 3. patients with proved malignancy or suspicious for malignancy by ultrasonography(us) or by fine-needle aspiration cytology (fnac). 4. previous surgery or radiotherapy to the neck. 5. thyroiditis.
evaluating of the impact of micronutrient interventions among adolescents in mozambique

Conditions: Anemia

Summary: this purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and the impact of a nutrition curriculum on diet diversity and anemia knowledge among adolescent girls.

this study aimed to implement and evaluate micronutrient supplementation interventions to improve adolescent nutrition, health, and education in mozambique. in conjunction with the mozambique ministries of health, education and culture, we conducted a two-arm cluster-randomized trial in three secondary schools, enrolling 28 girls' clubs (14 per arm). each club was comprised of around 18 girls aged 13 to 20 years. using constrained sampling to balance for age and school, clubs were randomly assigned to one of two intervention groups: 1) multiple micronutrient supplementation (mms) for five months plus a nutrition curriculum, or 2) iron and folic acid supplementation (ifas) plus a nutrition curriculum. girls enrolled in the mms arm consumed supplements daily for 4 months at home and weekly nutrition messages delivered through the clubs. girls enrolled in the ifas arm consumed supplements once a week for 4 months at school (the standard of care) and weekly nutrition messages delivered through the clubs. the study evaluated the effects of mms and ifas on anemia status and the impact of the nutrition curriculum on diet diversity and anemia knowledge.

Eligibility criteria:
inclusion criteria: adolescents aged 13-20 years enrolled in secondary school at study initiation member of an impact+ girls club at one of the participating schools consent provided by the parent assent provided by the adolescent exclusion criteria: no informed consent from parent or assent from adolescent self-reported pregnancy

Keywords: vitamins supplements iron folic acid mozambique micronutrients adolescents
effects of fingolimod on heart rhythm and heart rate variability in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the current study sought to prolong the observational interval after initiating medication with fingolimod and to measure the long-term effects of fingolimod on hr and hrv as an indicator of autonomic nervous system function in patients with rr-ms.

fingolimod (gilenya®; novartis pharmaceuticals corporation, east hanover, nj, usa) is a novel oral disease-modifying therapy that acts as a sphingosine-1-phosphate (s1p) receptor agonist and reduces the recirculation of lymphocytes to blood and peripheral tissues, including inflammatory lesions. a critical part of fingolimod therapy still remains in the screening and initiation phases because of the risk of cardiac events. it is well known that the first dose of fingolimod is associated with a decrease in heart rate (hr) and slowing of atrioventricular (av) conduction. patients were continuously observed for a minimum of 6 hours after taking fingolimod. because resurgence of heart rate began at 6 hours, the actual recommendation for observation is only 6 hours. data about the effect of fingolimod after this time period is lacking.

Eligibility criteria:
inclusion criteria: * ability to provide written informed consent in accordance with good epidemiological practice and local legislation * individuals over the age of 18 years * patients with relapsing-remitting forms of multiple sclerosis who were considered eligible for fingolimod treatment on a clinical basis. exclusion criteria: * insufficient knowledge of the german language (not able to understand and write the german language) * physical or psychological incapability to take part in the study

Keywords: heart rhythm fingolimod autonomic nervous system effects of medicinal substance
bioequivalency study of famciclovir 500 mg tablets under fasted conditions

Conditions: Herpes

Summary: the objective of this study was to prove the bioequivalence of famciclovir 500 mg tablets under fasting conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to famciclovir, penciclovir or any comparable or similar product.
motivational incentives for alcohol abstinence in american indian and native alaskan adults

Conditions: Alcohol Abuse

Summary: this study examines the impact of a culturally tailored version of contingency management treatment on alcohol in 400 alcohol dependent american indians and alaskan natives. participants will be recruited from addiction treatment agencies and throughout the community. those who complete a 4 week induction period will be randomized to receive 12 weeks of contingency management or a non-contingent control condition. individuals will then be followed for an additional 3-months to assess the long term efficacy of the treatment.


Eligibility criteria:
inclusion criteria: * self reported american indian/alaskan native * current alcohol dependence * 5 or more standard drink on 1 or more occasions in the last 30 days * ability to read and speak english * ability to provide written informed consent exclusion criteria: * illicit drug use greater than alcohol use in the last 90 days * a risk of dangerous alcohol withdrawal * any medical or psychiatric condition, such as organic brain disorder, dementia, or psychotic disorder
cuhk jockey club hope 4 care programme - hand of hope

Conditions: Stroke

Summary: the hong kong jockey club charities trust has supported cuhk to launch a three-year project 'cuhk jockey club hope4care programme' to implement four evidence-based advanced rehabilitation technologies in 40 local elderly day care centres and rehabilitation centres, to benefit the community. the interactive intention-driven hand training robotic system is used for neuromuscular rehabilitation of the hand and forearm. this can help stroke survivors to regain their hand functions through motor relearning.


Eligibility criteria:
inclusion criteria: * at least six months after the onset of a unilateral ischemic brain injury or intracerebral haemorrhage * upper-limb motor impairments due to stroke * metacarpophalangeal and proximal interphalangeal joints of fingers can be extended to 180 degree passively * spasticity during extension at the finger joints is lower than 3 as measured by the modified ashworth scale * detectable voluntary emg signals from the flexor digitorum and extensor digitorum muscles of the paretic hand * have sufficient cognition to follow the experimental instructions exclusion criteria: * have other neurological, neuromuscular, and orthopedic diseases * have shoulder or arm contracture/pain
investigation of the efficacy of extracorporeal shock wave therapy and kinesiotaping applied as an addition to conservative treatment in individuals with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: this study was conducted to compare the effectiveness of different treatment combinations in individuals with carpal tunnel syndrome (cts). participants were divided into three groups: the control group received only night splinting and exercise programme, while the second group received extracorporeal shock wave therapy (eswt) in addition. the third group received kinesiobanding in addition to night splinting, exercise and eswt. the study evaluates the effect of multimodal conservative treatment approaches on cts symptoms and aims to demonstrate the additional benefits of eswt and kinesiobanding in particular. the findings provide important clues for clinical practice.

carpal tunnel syndrome (cts) is a common entrapment neuropathy resulting from compression of the median nerve at the wrist level, with symptoms such as paresthesia, pain and loss of muscle strength. this study comparatively evaluated the effects of different conservative treatment combinations on symptoms and functional status in individuals with cts. participants were divided into three groups. the control group received the standard conservative approach of night splinting and exercise programme. extracorporeal shock wave therapy (eswt) group received eswt, which is known to increase tissue regeneration and blood flow, in addition to night splinting and exercise. in the eswt+taping group, in addition to night splinting, exercise and eswt, kinesiobanding, which aims to provide proprioceptive support and reduce oedema, was applied. pain intensity, symptom severity, functionality, hand grip strength and electrophysiological parameters were evaluated before and after treatment. this study draws attention to the importance of multidisciplinary and holistic approaches in the treatment of cts and offers important contributions to clinical practice.

Eligibility criteria:
inclusion criteria: * male or female patients between the ages of 18 and 65 who applied to ahi evran university physical medicine and rehabilitation outpatient clinic and were diagnosed with moderate or mild carpal tunnel syndrome by clinical, physical examination and emg * patients who understand and can apply the patient information form * patients who gave consent and participated in the study according to the informed consent form exclusion criteria: * cervical radiculopathy * polyneuropathy * brachial plexopathy * history of trauma or fracture of the wrist and forearm * systemic corticosteroid use, history of malignancy * history of carpal tunnel syndrome surgery * pregnant and lactating women * severe carpal tunnel syndrome, tenar atrophy on physical examination 9. * patient reluctance to participate in treatment

Keywords: carpal tunnel syndrome treatment kinesiotaping
multi-compression spot mammography

Conditions: Breast Diseases

Summary: in this study, participants, who are scheduled to have a breast biopsy, will have several extra spot mammogram images taken of the suspicious area. these images will be acquired with varying levels of compression. the images will then be analyzed to determine whether the type of lesion (malignant or benign) can be determined from the image data alone. the biopsy results will be used as a gold standard to determine the true malignancy status


Eligibility criteria:
inclusion criteria: * women 45 years and older * women with suspicious mammography findings requiring a biopsy exclusion criteria: * men * pregnant women

Keywords: breast mass breast lesion
maternal depression treatment in hiv

Conditions: Depression

Summary: cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (pmtct) care cascade at 8 antenatal care (anc) clinics in uganda.

this study is a cluster randomized controlled trial (rct) to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the pmtct care cascade at 8 anc clinics in uganda. at 4 experimental sites, task-shifted, depression care will include (1) depression screening and psychoeducation, (2) depression diagnosis, and (3) provision of evidence-based problem solving therapy (pst), or antidepressant therapy (adt) for those with severe and refractory depression (or who decline pst), to be implemented by trained peer mothers and midwife nurses, respectively. the 4 control sites will use usual care services for managing depression, which consist of referrals to a mental health specialist and access to the family support group program (comprehensive, monthly multi-session psychosocial program to enhance pregnancy management and pmtct adherence). at each site, 50 hiv-positive newly pregnant women (total n=400) who screen positive for potential depression will be enrolled and followed until 18-months post-delivery to assess how depression and depression alleviation relate to primary (adherence to each component of the pmtct care continuum, maternal virologic suppression) and secondary (infant hiv status; post-natal maternal and child health outcomes) outcomes, as well as processes of depression care (treatment uptake and depression alleviation among clinically depressed patients). a cost-effectiveness analysis will be used to compare the two study arms.

Eligibility criteria:
inclusion criteria: * detection of pregnancy through 24 weeks gestation (to ensure at least 12 weeks remaining antenatal period for assessing adherence to all stages of pmtct care cascade) * hiv-positive * positive screen for potential depression on 2-item patient health questionnaire (phq-2\>0) * on art for at least 4 weeks exclusion criteria: * unstable health (about to start art or on art \< 4 weeks; active, untreated opportunistic infection)
visceral lymphatic mapping using isosulfan blue in patients with cancer of the pancreas, colon, stomach, small intestine, or gallbladder

Conditions: Colorectal Cancer; Gallbladder Cancer; Gastric Cancer; Pancreatic Cancer; Small Intestine Cancer

Summary: rationale: diagnostic procedures, such as visceral lymphatic mapping using isosulfan blue, may help find cancer of the pancreas, colon, stomach, small intestine, or gallbladder and find out how far the disease has spread. purpose: this clinical trial is studying the side effects and how well visceral lymphatic mapping using isosulfan blue works in patients with cancer of the pancreas, colon, stomach, small intestine, or gallbladder.

objectives: primary * evaluate the safety and feasibility of visceral lymphatic mapping using isosulfan blue in patients with adenocarcinoma of the pancreas, colon, stomach, small bowel, or gallbladder. * evaluate the ability of surgically defined sentinel lymph nodes to predict whether other lymph nodes in the basin are involved with the tumor in these patients. secondary * compare the results obtained from the sentinel lymph node (i.e., positive or negative for metastatic disease) with the results obtained from the other nodes in these patients. * compare immunohistochemical analysis with standard analysis of the sentinel lymph nodes in these patients. * evaluate the value of intraoperative touch prep analysis of sentinel lymph nodes in these patients. outline: this is a pilot study. during surgical resection of the primary tumor, patients receive isosulfan blue subcutaneously 5 minutes before undergoing sentinel lymph node identification/excision and radical lymphadenectomy. tissue samples are analyzed by ihc for cytokeratins and cea.

Eligibility criteria:
disease characteristics: * diagnosis of adenocarcinoma of 1 of the following sites: * pancreas * stomach * colon * small bowel * gallbladder * patients with highly suspicious pancreatic lesions without definitive tissue biopsy are eligible * no prior uncontrolled visceral malignancy patient characteristics: * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception * no medical comorbidities that would preclude definitive resection * no known allergies to isosulfan blue prior concurrent therapy: * not specified

Keywords: adenocarcinoma of the gallbladder stage i pancreatic cancer stage ii pancreatic cancer stage iii pancreatic cancer stage iv pancreatic cancer stage i colon cancer stage ii colon cancer stage iii colon cancer stage iv colon cancer stage i gastric cancer stage ii gastric cancer stage iii gastric cancer stage iv gastric cancer localized gallbladder cancer small intestine adenocarcinoma adenocarcinoma of the colon adenocarcinoma of the pancreas adenocarcinoma of the stomach
multi-sensory intervention room application (mira) device in the nsicu

Conditions: Post Intensive Care Syndrome

Summary: the purpose of this research study is to determine the safety, feasibility, and efficacy of a device, mira, on the physical, mental, and cognitive health of neurosciences intensive care unit (nsicu) patients. the study device is a multi-sensory stimulation device named mira, which uses commercially available hardware and builds off the soluna software created by studio elsewhere, which produces audio and visual immersive experiences. the current device, model m1, is a prototype developed for sole investigational purposes of this study and is not commercially available. participants, who will be patients and staff of the nsicu, will complete questionnaires regarding safety, feasibility, and efficacy. the research team will enroll 20 patient and 15 staff participants. the trial is expected to last 12 months.


Eligibility criteria:
inclusion criteria: to be eligible to participate in this study, an individual must meet all of the following criteria: for nsicu staff: * current employee at nsicu * aged \>/= 18 for nsicu patients: * currently admitted to the mount sinai hospital nsicu for any diagnosis or a legally authorized representative (lar) for the patient, and expected to stay for at least 48 hours * provision of signed and dated informed consent form (icf) * stated willingness to comply with all study procedures and availability for the duration of the study * aged \>/= 18 * any sex or gender identity * currently admitted to the mount sinai hospital nsicu for any diagnosis or a legally authorized representative (lar) for the patient, and expected to stay for at least 48 hours exclusion criteria * not a mount sinai nsicu patient * no lar present and unable to consent

Keywords: post intensive care syndrome bio-experiential space biophilic design
a double blind study for the treatment of acute ulcerative colitis

Conditions: Ulcerative Colitis

Summary: a double-blind, randomized, 6-week, parallel-group design clinical trial to assess the safety and efficacy of asacol 4.8 g/day (800 mg mesalamine tablet) versus asacol 2.4 g/day (400 mg mesalamine tablet) for the treatment of moderately active ulcerative colitis (ascend iii).

this is a double-blind, randomized, multi-center, multi-national, active-control study in patients who are experiencing a moderately active flare of uc. patients will be randomly assigned to receive either asacol 2.4 g/day (400 mg tablet) or asacol 4.8 g/day (800 mg tablet) for 6 weeks. patients will be randomized to one of the 2 treatment groups in a 1:1 ratio. the objective of the study is to evaluate the safety and efficacy of asacol 4.8 g/day (800 mg tablet) compared to asacol 2.4 g/day (400 mg tablet) in this patient population. following successful screening, patients will be randomized to one of the two treatment arms. patients will be evaluated after 6 weeks of treatment with an interim visit after 3 weeks.

Eligibility criteria:
inclusion criteria: * patients 18-75 years with a confirmed diagnosis of moderately active flare of ulcerative colitis. * female patients need to be postmenopausal or using adequate contraception. exclusion criteria: * patients with isolated proctitis * patients with comorbidities or an investigative or commercialized treatments confounding interpretation of study results or compromising patients' safety in the trial.

Keywords: ulcerative colitis, inflammatory bowel disease
antibody response in hemodialysis and non-dialysis patients diagnosed with covid-19.

Conditions: Dialysis; Covid19

Summary: this is prospective cohort study aimed to compare antibody response against sars-cov-2 in dialysis patients and non-dialysis-dependent volunteers. the research hypothesis is that dynamic of igg antibodies against sars-cov-2 will differ in two groups. to determine whether there is a statistically significant interaction between factors "group" and "time" on the titer of igg antibodies against sars-cov-2, a two-way repeated measures anova will be used.

in both groups level of igg antibodies against sars-cov-2 will be measured at the day 1 (10 weeks from the date of first symptoms), weeks 8 and 16 from the day 1.

Eligibility criteria:
inclusion criteria: * age 18 years or older * sars-cov-2 infection within 10 weeks prior enrollment, confirmed by pcr or strongly suspected on computed tomography * providing informed consent exclusion criteria: * refusal to provide informed consent

Keywords: antibodies igg ckd hemodialysis