Kornimate/medical-research-clean huggingface dataset:
vitamin d repletion in primary hyperparathyroidism

Conditions: Primary Hyperparathyroidism; Vitamin D Deficiency

Summary: this study will look at the effect of 2 treatment regimens that contain vitamin d in a six-month treatment trial of patients with phpt who are vitamin d deficient. patients will be assigned randomly to one of 2 regimens, and will be followed with tests of their blood, urine and bones. this study should provide important information on the effect of vitamin d therapy in patients with phpt. in addition, data from this study will guide physicians as to how best to treat their patients who have phpt and vitamin d deficiency.

primary hyperparathyroidism (phpt) is a common disease in which the parathyroid glands produce excessive amounts of parathyroid hormone (pth), which regulates calcium levels. in primary hyperparathyroidism, high levels of pth remove too much calcium from bones and deposit the excess calcium in the blood, which is then filtered into the urine by the kidneys. bone health is threatened by the excess calcium loss which weakens the structure of the bones. many patients with primary hyperparathyroidism also have low vitamin d (25ohd) levels which is thought to further impair bone health. recent medical guidelines recommend treating patients with primary hyperparathyroidism who have low vitamin d levels with oral vitamin d but the optimal vitamin d dose and rate of repletion is unclear. it is, therefore, important to determine if replenishing vitamin d will improve bone health in primary hyperparathyroidism, and if so, to assess the impact of the rate of vitamin d repletion.

Eligibility criteria:
inclusion criteria: * diagnosed phpt, defined by an elevated serum calcium level (we will not study normocalcemic phpt) with elevated or inappropriately normal pth levels. * vitamin d3 less than 30 ng/ml exclusion criteria: * patients with familial hyperparathyroid syndromes * current or past use of the following medications: bisphosphonate within past 2 years, use of lithium or thiazide diuretics, current use of cinacalcet, use of aluminum containing medications, cimetidine, colestipol, or orlistat * malignancy, except cured basal or squamous cell skin carcinoma or other cured cancers that are at least five years free from recurrence * history or current diagnosis of certain medical diseases (including sarcoidosis, active infectious granulomatous disease, hiv/aids, chronic kidney disease (serum creatinine \> 1.5 mg/dl), liver disease; gi diseases known to affect calcium metabolism; secondary hyperparathyroidism); * we will also exclude patients with calcium above 11.5 mg/dl, urine calcium above 350 mg/day, and active nephrolithiasis because vitamin d repletion could potentially exacerbate hypercalcemia or hypercalciuria * other exclusions include protected individuals (institutionalized), prisoners, and any other prospective participant who might not be able to give voluntary informed consent.

Keywords: endocrinology metabolic bone disease primary hyperparathyroidism phpt vitamin d deficiency bone mineral density hyper-calcemia
efficacy of use of zinc in the treatment of acute diarrhea in infants

Conditions: Acute Diarrhea; Acute Gastroenteritis

Summary: the purpose of this study is to determine the effect of zinc in acute watery diarrhea in children. the investigators will evaluate the effect of product versus placebo.

background: acute gastroenteritis is one of the most and frequent disease in the childhood, today exist strong evidence of beneficial effect of use of zinc in acute diarrhea in children over 6 months. but there are not enough clinical trials to show this beneficial effect on children under 6 months. objectives: to evaluate the effect of zinc in the treatment of children under 6 months age with acute diarrhea. methods: a randomized clinical trial, controlled, double-blind. the investigators will have two groups of patients : one group will receive zinc plus oral rehydration and the other one will receive placebo plus oral rehydration; the parameters of evaluation are going to be the duration of diarrheal episode, number of diarrhea stools by day, weight of stool, nutritional state.

Eligibility criteria:
inclusion criteria: * all acute diarrhea exclusion criteria: * severe malnourishment * severe dehydration * systemic infections * coinfections

Keywords: acute diarrhea zinc children
to assess the safety and efficacy of travacom in patients with uncontrolled intraocular pressure

Conditions: Uncontrolled Intraocular Pressure

Summary: this study is a multi-site, unmasked phase iv study. travacom(r) is a combination topical ocular agent, containing travoprost and timolol, which lower intraocular pressure (iop) by complementary mechanisms of action. the safety and efficacy of both travoprost and timolol have been established as single and adjunctive therapy in well-controlled clinical studies in thousands of patients diagnosed with open angle glaucoma (oag) or ocular hypertension. the objective of this study is to assess the safety and efficacy of changing to travacom from prior pharmacotherapy in uncontrolled patients with open-angled glaucoma or ocular hypertension across india.


Eligibility criteria:
inclusion criteria: * must have a clinical diagnosis of ocular hypertension, primary open-angle or pigment dispersion glaucoma in both eyes. * must be willing to discontinue the use of all other ocular hypotensive medications prior to receiving the study medication for the entire course of the study. * must be able to follow instructions and be willing and able to attend all study visits. exclusion criteria: * a known medical history of allergy, hypersensitivity or poor tolerance to any component of travacom that is deemed clinically significant in the opinion of the principle investigator. * any abnormality preventing reliable applanation tonometer in either eye. corneal dystrophies. * any opacity or subject uncooperativeness that restricts adequate examination of the ocular fundus or anterior chamber of either eye.

Keywords: travacom glaucoma travoprost timolol
authentic connections for nurse leaders

Conditions: Stress

Summary: the purpose of this pilot study is to test the feasibility and outcomes of a supportive group-based intervention, authentic connections, to be used for nurse leaders at mayo clinic, rochester, in a collaboration involving faculty at arizona state university (asu) department of psychology, dr. sunyia luthar.


Eligibility criteria:
* in an nursing education specialist (nes) or clinical nurse specialist (cns) nurse leader role at mayo clinic rochester * female gender * a mother to at least one child or adult child

Keywords: nurse leader resilience parenting stress depression
validity of lung ultrasound in diagnosis of acute respiratory distress syndrome

Conditions: of Lung Ultrasound in Diagnosis of Acute Respiratory Distress Syndrome

Summary: to evaluate the validity of lung ultrasound compared to ct chest and chest radiograph for diagnosis of ards and prediction of successful weaning from mechanical ventilation in those patients compared to traditional methods.

57 patients will be diagnosed as ards by ct chest and clinical criteria, then will be compared between the findings by lung ultrasound and chest radiograph to detect the sensitivity of both imaging to ct chest as gold standard in diagnosis of ards patients

Eligibility criteria:
inclusion criteria: patients or legal guardian's consent .all patients with suspicious criteria of acute respiratory distress syndrome .hemodynamically stable in the absence or minimal of vasopressors. exclusion criteria: pregnant women. patients with traumatic lung injury or pneumothorax. surgical dressings over the right lower rib cage which would preclude ultrasound examination. presence of ascites. presence of lung collapse, fibrosis, or pleural effusion. -presence of any mass or mechanical factor in the chest or the abdomen interfering with the diaphragmatic mobility.

Keywords: lung ultrasound, acute respiratory distress syndrome
emote: a smartphone application for binge eating based on dbt skills

Conditions: Binge Eating

Summary: binge eating, whether formally diagnosed or occurring at subthreshold levels, is associated with adverse health consequences and decreased quality of life. access to accessible, cost-effective interventions that effectively address binge eating episodes is critical for individuals with this condition, and smartphone applications have demonstrated promise in treating binge eating and related disorders. this study aims to evaluate the efficacy of emote, a novel smartphone application for binge eating based on dialectical behavior therapy (dbt) skills. for this purpose, a randomized controlled trial will be conducted in which women who self-report binge eating episodes will be randomly assigned to the app intervention group or a waiting list group.

emote is a self-help application for women struggling with binge eating episodes. the application was developed based on dbt skills and has four modules: psychoeducation, mindfulness skills, emotion regulation skills, and distress tolerance skills. additionally, it includes two self-monitoring diaries that allow the input of data related to food, behaviors, feelings, and exercises. the application content will be delivered through text, audios, and videos. for this study, adult individuals with binge eating episodes who are fluent in portuguese and own a smartphone will be recruited. the recruitment will be conducted through social media, the university of porto, and other relevant institutions. participants who enrol in emote will be required to fill out online self-report instruments and provide their body mass index (bmi) at baseline (t0), two months (t1), and four months after randomization (t2). a researcher not involved in the study will conduct the randomization process. participants will be randomly allocated to two groups: the experimental and control groups. in the experimental group, the participants will have access to emote for eight weeks, while in the control group, the participants will be on a waiting list for eight weeks, and after this period, the participants will have access to emote. the investigators will analyze the changes in the frequency of objective and subjective binge eating episodes, eating disorder psychopathology, bmi, intuitive eating, depression, anxiety, stress, compensatory behaviors, mindfulness, and difficulties in emotion regulation.

Eligibility criteria:
inclusion criteria: * female; * aged 18 years or older; * self-report at least one binge eating episode over the past four weeks; * owned a smartphone; * fluent in portuguese. exclusion criteria: * attending psychotherapy (face-to-face or digital) or another clinical trial; * body mass index below 18.5; * self-report an average of eight or more episodes of binge eating or inappropriate compensatory behaviours per week; * being pregnant; * self-report bipolar disorder, psychotic disorder, substance abuse, suicidal ideation or borderline personality disorder.

Keywords: dbt binge eating feeding and eating disorders application
evaluation of sofosbuvir and daclatasvir combo in coivd-19 patients in egypt

Conditions: Covid19

Summary: sofosbuvir has been recently recommended as a possible antiviral for covid-19, based on structural studies and multiple alignment analysis. by comparing the positive-stranded rna genomes of hcv and sars-cov-2, it has been postulated that sofosbuvir might be an optimal nucleotide analogue to repurpose for covid-19 treatment


Eligibility criteria:
inclusion criteria: * mild- moderate covid-19 confirmed by pcr exclusion criteria: 1. patients on renal dialysis 2. severe covid-19 cases 3. patients on amiodarone therapy (given the reported fda warning of an interaction between amiodarone and sofosbuvir that might lead to severe bradycardia). 4. children \< 12 years 5. pregnant and breast feeding women 6. exacerbation of hepatitis b

Keywords: sofosbuvir daclatasvir
cbpr strategies to increase colorectal cancer screening in ohio appalachia

Conditions: Colon Cancer; Rectal Cancer

Summary: the purpose of this project is to implement and evaluate an intervention to increase and sustain rates of use of colorectal cancer (crc) screening among men and women aged 50 and older in 6 intervention counties in appalachia ohio. researchers will employ community-based participatory research (cbpr) in combination with two crc interventions that have been developed and piloted with community partners to improve crc screening

primary objectives: i. utilize cbpr methods to develop specific county-level media campaigns and a clinic-based chart reminder for 12 ohio appalachia counties focused on crc screening or an attention control message. ii. implement and test, using a group-randomized design, a staggered county-wide intervention program that consists of county-specific media campaigns, clinic-specific chart reminder systems, and a combination of both strategies in 6 randomly selected intervention counties vs. an attention control condition in 6 randomly selected control counties. iii. utilize process and outcome evaluation strategies to assess the efficacy of each strategy. iv. utilize the results to plan the dissemination of the intervention into 36 appalachian counties in 6 additional states of the appalachia community cancer network (accn) in a subsequent study. outline: participants are randomized to 1 of 2 arms. arm i: participants are exposed to the "get behind your health!" media campaign intervention comprising 3 phases: the media campaign, the medical chart reminder, and a combination of media campaign and chart reminder. participants also undergo telephone interviews during years 2-4. arm ii: participants are exposed to a media campaign, patient education material in clinics, and a combination related to healthy eating, "peaches" (promoting education in appalachia on cancer and healthy eating styles). participants also undergo telephone interviews during years 2-4.

Eligibility criteria:
inclusion criteria: * have a working phone number * resident of one of the 12 study counties * lived in that study county since the start of the project * no prior history of crc, familial/hereditary cancer syndrome (e.g. hereditary non-polyposis crc), polyps, or inflammatory bowel disease (crohn's disease) * not currently pregnant * be in good health (i.e., no contraindications to crc screening) exclusion criteria: * no working phone number * not a resident of one of the 12 study counties * does not live in the study county since the start of the project * has a prior history of crc, familial/hereditary cancer syndrome (e.g. hereditary non-polyposis crc), polyps, or inflammatory bowel disease (crohn's disease) * is currently pregnant * not in good health(i.e.has contraindications for crc screening)

Keywords: colorectal cancer screening ohio appalachia
clinical risk state for bipolar disorder in adolescents

Conditions: Bipolar Disorder; Schizophrenia

Summary: aim: the purpose of the study is to characterize the at-risk phases preceding a first episode of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors of the disease development. hypothesis a: over 6-24 months, 25% of at-risk youth will develop the full manifestations of bipolar disorder (bpd) or schizophrenia. hypothesis b: the symptoms utilized for characterizing the at-risk phase of bpd will differentiate between individuals developing bpd and schizophrenia.

prospective, naturalistic, cohort study aiming to characterizing the bipolar and psychotic prodrome thoroughly with a variety of clinical and biological measures.

Eligibility criteria:
inclusion criteria: 1. age: 12-18 years; 2. sex: male or female; 3. race/ethnicity: no restrictions; 4. definite or suspected chart diagnosis of bp-ii, bp-nos, cyclothymia, mdd, depressive disorder nos, dysthymia or mood disorder nos, schizophrenifiorm disorder or psychotic disorder nos; 5. subject and parent (if subject\<18) willing and able to provide written, informed consent/assent. exclusion criteria: 1. estimated premorbid iq \< 70; 2. meets dsm-iv criteria for bp-i or schizophrenia, pervasive developmental disorder, autism spectrum disorders, current substance dependence; 3. history of medical condition known to affect the brain; 4. current group home affiliation.
acupuncture as add-on to g-csf for febrile neutropenia-related hospitalization in doxorubicin-treated patients with sarcoma

Conditions: Febrile Neutropenia; Sarcoma; Doxorubicin Adverse Reaction; Hospitalization-Associated Infection

Summary: chemotherapy-induced febrile neutropenia (cifn) is a dangerous complication of many chemotherapy drugs, with current treatment with granulocyte colony-stimulating factors (g-csfs) accompanied by adverse effects, primarily muscle and bone pain. adult patients with sarcoma treated with doxorubicin-based chemotherapy have a high risk (\>40%) for developing cifn. acupuncture has been shown to have a potentially myelo-protective effect on bone marrow during chemotherapy, though its effect on the incidence of cifn-related hospitalization has yet to be examined. in the proposed study, patients with sarcoma will be randomly allocated (in a ratio of 1:1) to group a, receiving acupuncture during cycles 1, 3, and 5; or group b, during cycles 2, 4, and 6, with the study oncologist blinded regarding allocation. acupuncture will be administered on the first day (d1) and the 8th day (d8) of the chemotherapy cycles, with press-tack needles on d1 to d8, and patients will be taught to self-treat with acupressure from d8 to the next cycle. the incidence and duration of hospitalization due to cifn will be examined, as will adherence to the chemotherapy regimen; g-csf-related pain; and other outcomes using 3 quality-of-life-focused questionnaires. the study findings will have important implications regarding the role of acupuncture in the treatment of patients treated with chemotherapy drugs with a high risk for cifn, such as those used in the treatment of sarcoma.


Eligibility criteria:
inclusion criteria: * age 18-65 years * diagnosed with sarcoma of any stage * scheduled for doxorubicin-based chemotherapy * function ecog status score of 0-1 exclusion criteria: * not fulfilling all inclusion criteria * unwilling or unable to provide written informed consent for study participation

Keywords: febrile neutropenia acupuncture sarcoma doxorubicin hospitalization
harnessing online peer education opioid study

Conditions: Medication Compliance; Pain

Summary: the investigators have created an online peer support platform for chronic pain patients on opioid medications. this platform provides peer support and online mental health counselor run support groups to help participants manage pain and not abuse opioid medications.

this study determined the feasibility, acceptability, and preliminary efficacy of an online support and risk reduction platform to prevent opioid misuse and abuse. this is an urgent area of research; opioid misuse/abuse has reached epidemic proportions in recent years. it is linked to causing the largest drug epidemic in the history of the united states and has become the top priority of the us surgeon general. because the opioid crisis (including heroin use) is believed to have largely originated from chronic pain patients' opioid prescriptions, this application will initially focus on the needs of chronic pain patients on opioids who are high risk for addiction and overdose. later versions of the technology will expand to the broader population of people affected by the opioid crisis, including heroin users. although low cost, novel interventions are needed to reduce opioid misuse and abuse, before they lead to addiction and fatal overdose, only 6 behavioral (non-pharmacological) randomized controlled trials have been successfully conducted in this area to date (with our group having conducted one of them), creating a tremendous need for solutions to the opioid crisis. building off extensive preliminary research that our team conducted, including piloting technology-based behavior change interventions among chronic pain patients, and developing artificial intelligence (ai)-based prediction models of opioid outcomes, we propose to design and test the feasibility, acceptability, and preliminary efficacy of an online peer social support and clinical counseling community to reduce opioid misuse/abuse among chronic pain sufferers.

Eligibility criteria:
inclusion criteria: adults over 18, comm scores at risk of misuse, prescribed opioids by doctor - exclusion criteria: cancer patients, elicit drug users, under 18 years -
feasibility of the preparation of an advanced therapy medicinal product for dental pulp regeneration

Conditions: Dental Stem Cells; Dental Pulp Regeneration

Summary: current endodontic treatment are based essentially on the ouster of parenchyma in case of trauma or irreversible pulp inflammation. these situations typically affect immature teeth in subjects aged from 8 to 15 years. consequently, loss of a functional pulp is leads to discontinuation of root development and apical closure. the challenge for the clinician in the management of such situations is then preserving a pulp vitality. but current practices consist in a filling of the endo-canal system with an inert or semi-inert material. in this case, no pulp vitality is present. new treatment methods are needed. the objective pulp'r is the study the feasibility of preparing an autologous combined advanced therapy medicinal product (atmp) for dental pulp regeneration in the patient with irreversible pulp inflammation or dental trauma.


Eligibility criteria:
inclusion criteria: * patients aged from 8 to 15 years, with at least one tooth affected by a carious process, * patients aged from 8 to 15 years with major trauma preventing the maintenance of the tooth in the arch * patients aged from 16 to 20 years requiring avulsion germs wisdom teeth, * ability to carry out the extraction of pulp chamber content * signature of informed consent (from the patient and his guardian) * indication that the subject has understood the purpose and procedures required by the study and agrees to participate in the study and comply with the requirements and limitations inherent in this study, * patient with french social insurance. exclusion criteria: * lack of ability to collect the dental pulp, * presence of necrosis in pulp complex or the possibility of preserving the pulp through appropriate techniques, * legal incapacity or limited legal capacity * patient unlikely to cooperate in the study and / or low cooperation anticipated by the investigator, * patient without health insurance, * the patient is in the period of exclusion of another study, * patients with congenital pathology of dental pulp (amelogenesis and dentinogenesis imperfect) * patient with intrapulpal calcification or violations of pulp obliteration * teeth having external or internal inflammatory resorption * teeth diagnosed with pulp necrosis process * teeth undergoing fragmentation for their avulsion * time of pulp air exposition \> 2 hours (risk of bacterial contamination)