Kornimate/medical-research-clean huggingface dataset:
evaluation of antral biopsies obtained in normal esophagogastroduodenoscopy

Conditions: Gastritis H Pylori; Gastritis Chronic; Intestinal Metaplasia

Summary: esophagogastroduodenoscopy (egd) is commonly performed in patients presenting with abdominal pain and dyspeptic symptoms, serving as a valuable diagnostic and therapeutic tool. while various methods are available for biopsy sampling when mucosal pathology is observed during egd, the practice of obtaining biopsies from endoscopically normal mucosa remains controversial. although there is literature suggesting that routine biopsies from the antrum and duodenum for surveillance purposes increase costs, pathological findings can sometimes be detected in areas that appear normal on mucosal examination, leading to potential changes in treatment approach if biopsies are obtained. in this study, a retrospective evaluation of the prevalence of various pathologies detected in biopsies obtained from endoscopically normal mucosa in patients who underwent egd was reported as normal.

esophagogastroduodenoscopy (egd) is a commonly used diagnostic tool in upper gastrointestinal system diseases. its widespread use is facilitated by its minimally invasive nature, the possibility of therapeutic procedures, low complication rates, and broad applicability. although there are numerous guidelines regarding approaches to endoscopic pathologies and diseases detected during esophagogastroduodenoscopy, the necessity of biopsy sampling from mucosal areas that are endoscopically normal remains controversial. in this study, patients aged between 18 and 95 who underwent egd at the sisli hamidiye etfal training and research hospital surgical endoscopy unit between 2021 and 2023, with no pathology detected during the endoscopic examination and who underwent biopsy sampling, will be evaluated. history of upper gastrointestinal surgery, detection of the endoscopic pathology, and not having biopsy sampling will be considered as exclusion criteria. the rate of detection of histopathological findings in the obtained biopsies, severity and activity of gastritis, rate and density of helicobacter pylori detection, and rate and extent of intestinal metaplasia will be evaluated.

Eligibility criteria:
inclusion criteria: * patients aged between 18-95 * endoscopically normal esophagogastroduodenoscopy * sampling biopsies must be obtained exclusion criteria: * history of upper gastrointestinal surgery * abnormal endoscopic findings such as gastritis, ulcer, hiatal hernia, pyloric deformity, alkaline reflux * not having biopsy

Keywords: esophagogastroduodenoscopy routine biopsy intestinal metaplasia
partial pten deletion in breast cancer

Conditions: PTEN Gene Deletion

Summary: * detection of chromosome 10q23 deletion including pten locus in breast cancer patients. * correlation between pten deletion and clinicopathological characteristics in breast cancer patients.

breast cancer is the most common carcinoma detected in women, accounting for about one fifth of new cancer cases in females. in egypt breast cancer is the most common malignancy in women, accounting for 38,8% of cancers in this population, with the estimated number of breast cancer cases nearly 22700 in 2020 and forecasted to be approximately 46000 in 2050. surgical removal of the cancer represents the standard of care followed by radiation and adjuvant therapy in patients considered to be at particular risk for systemic disease. estimation of prognosis is of vital importance for tailoring adjuvant therapy in individual breast cancer patients. conventional pathological parameters such as histological grade, tumor size and presence of lymph node metastasis are not accurate enough to select subsets of patients who are at sufficiently low risk of progression to be spared extensive adjuvant therapy without compromising the prognosis. much hope is placed on cytogenetic features analysis which might help to improve prediction of patient prognosis. fluorescence in situ hybridization (fish) is a molecular cytogenetic technique that enables the detection of genetic abnormalities such as gene amplification, deletions, and chromosomal rearrangements. deletions of chromosome 10q23 including the pten (phosphatase and tensin homolog) locus are known to occur in breast cancer patients. the pten gene is a phosphatase which metabolises pip3, the lipid product of pi 3-kinase, directly opposing the activation of the oncogenic pi3k/akt/mtor signalling network. inactivation of pten leads to constitutively activated levels of akt, thus promoting cell growth, proliferation, survival and migration through multiple downstream effectors. pten is one of the most frequently deleted genes in various human cancer types. in breast cancer, the frequency of pten deletions or reduced expression varies from 4 % to 63 %.

Eligibility criteria:
inclusion criteria: * all stages of breast cancer in females. exclusion criteria: * breast cancer in males.
preemptive analgesic effects of rectus sheath block in laparoscopic cholecystectomy patients

Conditions: Preemptive Peripheral Nerve Block; Pain, Postoperative; Acute Pain

Summary: the purpose of this study was to investigate the effectiveness of preemptive effect of rectus sheath block (rsb) and intercostal nerve block (icnb) on postoperative visceral pain in laparoscopic cholecystectomy (llc). after induction of general anesthesia, group of patient is decided randomly. in group pre, rsb and icnb are performed with 0.25% ropivacaine 40ml before the operation. in group post, rsb and icnb are performed with 0.25% ropivacaine 40ml after the operation. measure the nrs and compare the rescue analgesic dose used at 0, 0.5, 1, 2, 6, 9, 18, and 24 hours after arrival at the recovery room.


Eligibility criteria:
inclusion criteria: 1. adults between the ages of 20 and 80 2. scheduled laparoscopic cholecystectomy patient 3. asa class 1 or 2 4. patients who have voluntarily agreed in writing to participate in the trial exclusion criteria: 1. patient with side effects on local anesthetics or steroids 2. patient who are taboo of peripheral nerve block such as blood clotting disorder, infection, etc. 3. patients with uncontrolled medical or psychiatric problem 4. patient does not agree to participate in the study 5. patients who are pregnant or lactating 6. patients whose visceral pain is expected to be too severe 7. patients receiving a single laparoscopic cholecystectomy (including using a robot)

Keywords: preemptive analgic effect rectus sheath block laparoscopic cholecystectomy
clinical evaluation of left ventricular auto threshold algorithm (levea)

Conditions: Heart Failure

Summary: the purpose of the levea study is to assess the performances of a new automatic left ventricular auto threshold (lvat) algorithm (in-clinic lvat algorithm) when used by physicians during in-hospital follow-up.

"in-clinic lvat" feature is a non ce-marked feature designed to be activated by the physician during 2 hospital follow-ups: * first visit: planned to be conducted 15 days maximum after inclusion * second visit: planned to be conducted between 1 and 3 months after the first visit the evaluation consists in the comparison between the threshold value provided by the algorithm and the threshold value obtained manually by the physician.

Eligibility criteria:
inclusion criteria: * subject already implanted (de-novo, upgrade or replacement) according to the relevant esc guidelines \[1\]: * with is1 platinium sonr crt-d (models 1811, 1841, ce-marked) for maximum of 5 days or; * with is4 platinium sonr crt-d (model 1844, ce-marked). * right atrial, right and left ventricular leads must be implanted. only bipolar and quadripolar for left ventricular lead. * reviewed, signed and dated informed consent. exclusion criteria: * subject included in another clinical study that could confound the results of this study; * malfunction or dislodgment of right atrial, right and left ventricular implanted leads; * subject diagnosed with permanent atrial fibrillation; * known pregnancy; * minor age; * under protection or guardianship; * unavailability for scheduled follow-up or refusal to cooperate

Keywords: heart failure, crt
effect of subtalar and talocrural joint mobilization on foot ranges and posture in diabetic patients

Conditions: Diabetic Foot

Summary: the aim of this research is to determine the effects of mobilizations on foot ranges and posture in people with type 2 diabetes mellitus. randomized controlled trials will be done at dr. akbar niazi teaching hospital anth, bhara kahu islamabad. the sample size will be 42. the subjects were divided in two groups, with 21 subjects in group a and 21 in group b. study duration is 6 months. sampling technique applied was non probability convenience sampling technique. both males and females of aged 45-65 having type 2 diabetes were included. tools used in the study are spirit level mobile application (android)-smartphone goniometer, foot posture index-6 and dn4-douleur neuropathique 4 questionnaire.

diabetes mellitus is a heterogeneous metabolic disease due to insulin disturbance affecting around 422 million people worldwide according to the who it is characterized by hyperglycemia and ischemia, as a result of defects in insulin secretion. type 2 diabetes mellitus (t2dm) ranks highly on the international health agenda as a global pandemic and as a threat to human health and global economies. the number of people with t2dm worldwide has more than doubled during the past 20 years. lower extremity musculoskeletal complications are frequently observed in people with diabetes mellitus (dm) and peripheral neuropathy (pn) and include limited joint mobility, impaired strength, atrophy causing increased stiffness of articular capsule, ligaments and tendons. ankle planter flexion and dorsiﬂexion was found to be decreased preventing the ankle from reaching its closed-pack position by holding the ankle in a hyper supinated position. people with dmpn have a dorsi flexed foot and ankle position resulting in slow gait with prolonged disease secondary to the peripheral effect of the disease on other body systems. according to abate and colleagues there is a 24% reduction in ankle plantar-flexion range of motion in people with dm. manual mobilizations have proved to decrease the stiffness at ankle joint improving the ranges in previous studies previous literature have shown that interventions to address foot and ankle plantar-flexion mobilizations could improve its function by increasing flexibility reduce the risk of plantar ulceration. distraction of the distal tibiofibular joint has been thought to increase space and decrease impingement in the talocural joint to allow full ankle dorsiflexion.

Eligibility criteria:
inclusion criteria: * indoor patients diabetes mellitus type 2 * both male and female gender * age between 45-65 years * with \& without peripheral neuropathy exclusion criteria: * any neurological impairment patients with foot ulcer / amputation * history of surgical procedure of lower limb * trauma/ recent fracture of lower limb * patients with severe retinopathy * congenital foot deformity * osteoarthritis of ankle joint

Keywords: foot mobilizations ankle range of motion diabetic neuropathy foot posture index
effects of the use of platelet-rich fibrin on bone regeneration after impacted third molar surgery

Conditions: Fibrin/Therapeutic Use; Blood Platelets; Molar, Third; Bone Regeneration

Summary: the purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.


Eligibility criteria:
inclusion criteria: * healthy patients * preoperative platelet count higher than 150,00/ mm3 * patient who required bilateral mandibular third molar extractions exclusion criteria: * smokers patients * alcoholics patients * patients whom the inferior second molar was missing * patients who had acute pericoronitis on the inferior third molar * severe periodontal disease

Keywords: platelet-rich fibrin third molar bone regeneration
incidence and prognostic factors for lower extremities injuries in polish youth soccer academy.

Conditions: Musculoskeletal Diseases; Athletic Injuries

Summary: the aim of our study is to obtain data on the occurrence of injuries, their mechanisms and types among children and adolescents from a youth soccer club. in addition, in order to determine the potential risk of injury, the investigators will examine the prognostic factors on the basis of tests assessing the antropometric, anatomical, physical and fitness characteristics.

during the 2020/2023 seasons, participants will be obliged to report injuries to to sports physiotherapists. supervision and data collection on injuries will be documented by experienced sports physiotherapists. using the injury record form, a standardized definition and classification of injuries in line with the international olympic committee consensus describing methods for recording and reporting epidemiological data on injuries and diseases in sport (bahr et al. 2020). in addition, the data will also come from a physiotherapeutic examination, and in the case of severe injuries (requiring specialist consultation), a medical examination (orthopedic and / or neurological) and imaging tests. training and match exhibition (time spent by participants during training units and match games) will be recorded individually for each participant by the coaches of a given team (year). the given data (in minutes) will allow to determine the total time of sports exposure. the participant's missed training and / or competition due to an injury will also be analyzed.

Eligibility criteria:
inclusion criteria: * healthy, not reporting health problems on the day of the examination * active participation in football competitions in the football club * having a medical permit to participate in football games * signed consent of the parent / guardian to participate in the study exclusion criteria: * unable to participate in the study * restrictions related to full participation in football games and / or training
the effect of eye mask and earplugs on sleep quality and delirium in coronary artery bypass graft patients: a randomized controlled study

Conditions: Cardiovascular Surgical Procedures

Summary: coronary artery bypass grafting is the most commonly performed surgical procedure among cardiovascular diseases. nursing care for patients undergoing cardiac surgery involves a process that includes preoperative preparation and subsequent close monitoring of neurological, cardiac, respiratory, vascular status, kidney function, and pain. sleep disturbances are observed after cardiac surgery. sleep plays a critical role in the body's maintenance, repair, and renewal processes. improved sleep can reduce patient agitation and decrease the risk of delirium. the presence of delirium leads to increased care requirements and prolonged hospital stays, which in turn raises hospital costs. enhancing sleep quality and preventing delirium after surgery have positive effects on clinical patient outcomes. this study is designed to determine the effects of using eye masks and/or earplugs on sleep quality and delirium in patients undergoing coronary artery bypass grafting during nighttime sleep. this research is a randomized controlled clinical trial.


Eligibility criteria:
inclusion criteria: -patients who voluntarily agree to participate in the study * those who have undergone coronary artery bypass graft surgery * those between the ages of 18-79 * those who are cooperative and oriented * those who are literate * those who speak turkish * those whose initial delirium scale score (nu-decs) is less than 2 * those whose glasgow coma scale score is \>13 will be included in the study. exclusion criteria: * • patients diagnosed with sleep disorders, * those using sleeping pills, * those who have a habit of using an eye patch while sleeping, * those who were not transferred to the clinic on the first day after surgery and whose treatment continues in the intensive care unit, * those who develop complications and/or need to be re-operated, * those who need treatment other than routine treatment, * patients with hearing or vision problems will be excluded.

Keywords: cardiovascular surgical procedures, delirium, sleep
oral fluoride bioavailability by the consumption of meals prepared with fluoridated water or salt

Conditions: Fluoridation

Summary: this study will assess the concentration of fluoride in saliva and dental biofilm (fluid and solids) during and up to 2 hours after the consumption of typical brazilian meals prepared with fluoridated water (0.7 ppm f) or fluoridated salt (250 mg f/kg). typical brazilian meals (rice, beans, meat with vegetables) will be prepared using fluoridated water, salt, or non-fluoridated water and salt. in an crossover design, twelve volunteers will eat 4.67 g of food/kg body weight of each meal, on fasting, during 15 min. before the ingestion, unstimulated saliva and dental biofilm will be collected for determination of fluoride concentration. during the meal, 3 samples of the alimentary bolus (at 5, 10 and 15 min of mastication) will be collected for determination of fluoride concentration. dental biofilm will be collected immediately after the ingestion of the meal. saliva will then be collected after 5, 10, 15, 30, 60 and 120 min. all samples will be analyzed for fluoride using an ion-specific electrode. in order to standardize biofilm formation, during lead-in and wash-out periods, volunteers will: 1. brush their teeth with non-fluoride toothpaste; 2. refrain from brushing superior posterior teeth for 2 days before each phase; and 3. chew sucrose-containing chewing gum 5 times/day, for 10 min, during the 2 days prior to each phase. groups will be compared by anova and tukey test.


Eligibility criteria:
inclusion criteria: * good general health * good oral health * not having used topical fluorides in the last 2 months exclusion criteria: * poor general health * poor oral health * breastfeeding * expecting mothers

Keywords: water salt oral fluids plaque dental caries
safety of post-transplant alpha-beta depleted t-cell infusion following haploidentical stem cell transplant (haplo sct)

Conditions: Hematologic Neoplasms; Graft-Versus-Host Disease

Summary: the purpose of this study is to determine the safety and efficacy of post-transplant cyclophosphamide and a post-transplant infusion of donor cells, that have been specially processed to remove alpha beta t-cells, in patients undergoing a haploidentical allogeneic stem cell transplant to help reduce the risk of relapse without increasing the risk of graft-versus-host disease.

transplant patients participating in this clinical trial will receive one of 3 standard pre-transplant chemotherapy preparative regimens as appropriate for their specific disease. they will then receive a standard non-manipulated donor stem cell infusion on transplant day (day 0) followed by cyclophosphamide (days +3 and +4) and an alpha-beta t-cell reduced donor stem cell infusion on day +7.

Eligibility criteria:
inclusion criteria: * neoplastic hematological disorder with indication of allogeneic transplant * no available suitable hla-matched donor * adequate cardiac, pulmonary, renal, and hepatic function * karnofsky performance status score greater than or equal to 70% exclusion criteria: * medication non-compliance * no appropriate caregiver identified * uncontrolled medical or psychiatric disorder * active central nervous system (cns) neoplastic involvement * known allergy to dimethyl sulfoxide * hiv1 or hiv2 positive * pregnant or breastfeeding

Keywords: stem cell transplant
message-based psychotherapy and digital treatment sequences for depression

Conditions: Study Adherence; Depressive Disorder

Summary: this partnership between talkspace and the uw alacrity center will determine how effective unlimited text-based psychotherapy for depression is when compared to once-a-week psychotherapy. this study will also determine what the best treatment options are for people who are not responding well to either unlimited texting or weekly psychotherapy. the results of this study will be a new product version of message-based care that can tailor psychotherapy intensity based on the needs of future consumers with depression.

this is a fast track sbir proposal that will (1) test the effectiveness of daily, message-based psychotherapy (mbp) for depression, compared to traditionally delivered, video-chat psychotherapy (vcp) and (2) develop an evidence-based treatment sequence for those who do not respond to either daily mbp or vcp. phase 1 consists of a pilot study to determine the best incentive model to retain a sample of people 18 years old and older with depression into a smart trial. information from this pilot will inform the retention strategy for phase 2. phase 2 is a 12-week, randomized clinical trial using a smart design to test the following aims: 1. determine the relative effectiveness of daily mbp compared to weekly vcp in treating symptoms of depression and improving social functioning; 2. for those who fail to respond to 6 weeks of weekly vcp only, determine whether the addition of daily messaging, or a switch to monthly video-chat plus daily messaging improves depression and functional outcomes; and 3. for those who fail to respond to 6 weeks of daily mbp, whether the addition of monthly video-chat or weekly video-chat improves outcomes. participants will provide data on mood, activity, and functioning, and we will collect data on use of treatment (texts and sessions), and working alliance.

Eligibility criteria:
inclusion and exclusion criteria are the same for phase 1 and phase 2. inclusion criteria: * 18 years old or older * english or spanish speaking * live in the united states * score of 10 or greater on the phq-9 screening * receive a diagnosis of depression from a talkspace intake clinician exclusion criteria: * under the age of 18 * non-english or spanish speaking * do not meet criteria for a depressive disorder * participants with active suicidal ideation or with a primary diagnosis of psychosis will also be excluded and referred to intensive care.