Kornimate/medical-research-clean huggingface dataset:
training procedural simulation of nurses in reducing complications related to arteriovenous fistula puncture

Conditions: Nurse's Role; Simulation; Arteriovenous Fistula

Summary: interest of training in procedural simulation of nurses in the reduction of complications related to arteriovenous fistula puncture in hemodialysis patients

primary objective : to compare the number of complications related to arteriovenous fistula (avf)puncture before and after a complete simulation training program, on a fistula arm of procedural simulation (conceptualization of the approach + puncture + palpation + identification + use of ultrasound) secondary objective (s): compare other adverse events related to avf puncture during a hemodialysis session

Eligibility criteria:
inclusion criteria: * patients whose nurse is trained in hemodialysis receiving a fav puncture in the hemodialysis unit of the nephrology department, dialysis, transplantation exclusion criteria: * patients with avf puncture in the emergency / withdrawal area of the nephrology department, dialysis, transplantation

Keywords: task trainning procedural simulation
reducing cost of azythromycin by transferring from iv to oral therapy

Conditions: Pneumonia

Summary: intravenous azythromycin therapy is considerably more expensive than oral therapy. the investigators believe that intravenous therapy is prolonged more that necessary and that oral therapy can be used much earlier in the course of the disease. the investigators plan to check if that statement is true and intervene in order to shorten the intravenous therapy.

the study will be performed in two stages. first a retrospective review of medical files of 50 patients hospitalized in the haemek medical center with severe community acquired pneumonia, treated with azythromycin. the files will be reviewed for the criteria clinical improvement, and for azythromycin therapy, oral or intravenous. the results of this review will help us define the appropriate behavioral intervention in order to cause doctors to transfer from iv to po therapy at the earliest appropriate time. an intervention such as posters, pharmacy overseeing etc will be introduced. 3 months after the intervention, an additional 50 files of pneumonia patients treated with azythromycin will be reviewed in order to check the efficacy of the intervention. the review board and the nih will be updated about the intervention, as soon as the investigators have decided what intervention is appropriate

Eligibility criteria:
inclusion criteria: * all patients hospitalized with community acquired pneumonia treated by azythromycin exclusion criteria: * age under 18

Keywords: azythromycin community acquired pneumonia intravenous oral
evaluation of diet and exercise in patients with non-alcoholic fatty liver disease

Conditions: Fatty Liver

Summary: moderate exercise with a low fat and/or a moderate fat with low processed carbohydrate diet will have a greater effect on slowing disease progression and reversing hepatic steatosis and/or necro-inflammation in the liver of adult patients with nafld and nash when compared to a regular healthy diet alone.


Eligibility criteria:
inclusion criteria: * age 18-70 yrs * deers eligible (dod beneficiary) * all participants must plan to be in the area for at least nine months * liver biopsy confirmed nafld/nash (nas score evaluating steatosis, lobular inflammation and hepatocyte ballooning) within the past 6 months exclusion criteria: * alcohol consumption \> 20 g/d or history of alcohol abuse * hepatitis a, b, c * chronic liver disease of any other etiology * fatty acid oxidation disorder (inborn errors of metabolism) * insulin therapy regime for treatment of diabetes * pregnancy

Keywords: nafld nash
fistula-in-ano in infants and children

Conditions: Fistula in Ano

Summary: in this prospective, randomized trail, duration of non-cutting seton placement in patients with fistula-in-ano is evaluated.

in this prospective, randomized trail, patients are treated in case of fistula-in-ano with non-cutting seton placement. they are then randomized 1:1 in either group a (duration of placed seton for 4 weeks) or group b (duration of placed seton for 12 weeks). patients are participating after informed consent is obtained.

Eligibility criteria:
inclusion criteria: * any patient with fia and treatment with non-cutting seton placement in our institution * regardless of underlying diagnoses * age 0-18 years exclusion criteria: * none
the effects of high-intensity interval training on mental health and inflammation

Conditions: Anxiety; Depressive Symptoms; Inflammation

Summary: the present study investigated the effects of high-intensity interval exercise training and placebo-exercise on mental health and inflammation using a randomized control trial. the study also examined how anxiety symptoms prior to high-intensity interval training may influence improvements in fitness. inactive young adults underwent nine weeks of either high-intensity interval training or their regular routine. questionnaires, a blood draw and a maximal exercise test were conducted the week before and week after the intervention. it was hypothesized those who underwent high-intensity interval training would experience greater reductions in their depression, anxiety, and inflammation than those who were in the placebo control group. it was also hypothesized those who had high anxiety symptoms at the start of high-intensity interval training would experience smaller improvements in fitness than those who had low anxiety symptoms.


Eligibility criteria:
inclusion criteria: * full-time student at mcmaster university * speak, read and understand english exclusion criteria: * exercising for more than 150 minutes of moderate-to-vigorous physical activity per week
oud (opioid use disorder) target trial

Conditions: Opioid Use Disorder

Summary: in this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. the investigators are trying to learn two things: 1. can an mri brain marker be used to predict which participants will be successful in quitting opioids with buprenorphine? 2. does adjunctive treatment with repetitive transcranial magnetic stimulation (rtms) help people quit using opioids more than a sham (placebo) version of rtms? in order to complete the study the investigators will ask participants to: * complete an mri within 5-days of starting buprenorphine and again after they are on a full stable dose 1-3 weeks later. * undergo study-treatment with 50-sessions of either real or placebo rtms in as little as 1-week (10-sessions-per-day for five days) or as long as over 6-weeks. * meet with the investigators once per week over the following 12-weeks to see if the participants have been able to quit using opioids over that time.


Eligibility criteria:
inclusion criteria: 1. age 18 or older; all genders included. 2. intellectual level sufficient to provide informed consent and accurately complete assessment instruments (english speaking/writing). 3. meet dsm-5 criteria for moderate or severe oud. individuals may also meet criteria for another substance use disorder (with the exception of alcohol or sedative/hypnotic); but must identify opioids as their primary substance. 4. starting buprenorphine and planning on opioid abstinence exclusion criteria: 1. pregnant, breast-feeding, or planning on getting pregnant. 2. alcohol or sedative/hypnotic use disorders (seizure risk). 3. history of/or current psychotic disorder (e.g. schizophrenia). 4. current or lifetime bipolar disorder. 5. unstable axis-i condition requiring starting a new medication. 6. active suicidal ideation / suicide attempt within 90 days. 7. history of/or current dementia or other cognitive impairment. 8. contraindications to receiving rtms or undergoing mri (implanted ferromagnetic metal, history of or high risk of seizure, implanted device). 9. unstable general medical conditions.
a study to test the safety and antibody response of v212 in healthy adults (v212-004)(completed)

Conditions: Herpes Zoster

Summary: the purpose of this study was to assess the safety and tolerability of gamma-irradiated varicella-zoster virus (vzv) vaccine a (part 1) and gamma-irradiated vzv vaccine b and c (part 2) and to determine if they were immunogenic when administered to healthy individuals, as measured by vzv-specific antibody responses by glycoprotein enzyme-linked immunosorbent assay (gpelisa). the primary hypothesis was that gamma-irradiated vzv vaccine a (part 1) and gamma-irradiated vzv vaccine b and c (part 2) would elicit an acceptable vzv-specific immune response. the secondary hypothesis for part 1 of the study was that heat-treated vzv vaccine would elicit an acceptable vzv-specific immune response.


Eligibility criteria:
inclusion criteria: * must be 50 to 59 years of age * no fever on vaccination days * must have had chickenpox or lived in an area where the chickenpox virus is prevalent for 30 or more years * females of child-bearing potential must use acceptable forms of birth control exclusion criteria: * prior history of shingles * prior receipt of any chickenpox or shingles vaccine * pregnant or breastfeeding * received or expect to receive a live virus vaccine (such as measles, mumps, rubella) from 4 weeks before the first visit through the last visit * received or expect to receive an inactivated vaccine (such as tetanus or pneumonia) from 7 days before the first visit through the last visit * received immunoglobulin or blood products * receiving treatment that may weaken the immune system * have an immune system disorder

Keywords: herpes zoster (shingles)
the prognostic impact of right ventricular systolic dysfunction on the survival of patients with sepsis and septic shock

Conditions: Sepsis and Septic Shock

Summary: this study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. prospective cohort study of adult patients admitted at burapha university hospital from october 1, 2022 through june 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. right ventricular systolic dysfunction was defned by the american society of echocardiography criteria. outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(icu) stay and duration of mechanical ventilation.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * diagnosed with sepsis or septic shock according to sepsis-3 criteria * received an echocardiogram within 72 hours after admission exclusion criteria: * prior diagnosis of pulmonary hypertension, * cor-pulmonale, * significant valvular heart disease, * acute coronary syndrome, * aortic dissection, * heart failure * inability to follow up within 28 days

Keywords: right ventricular systolic dysfunction
characterization of neuromuscular function and fatigue after breast cancer treated with adjuvant chemotherapy (protect-04)

Conditions: Breast Cancer

Summary: this is a transversal monocentric study comparing two groups of women (group 1, patient group : patients who have been treated for a breast cancer with taxane-based chemotherapy ; group 2, control group : healthy volunteers). the aim of this study is to evaluate if a difference exists regarding the maximal isometric muscle strength between group 1 and 2.

all subjects will be evaluated a single time during two hours. for patients from group 1 the evaluation should take place within the two weeks that follow the end of adjuvant treatment. there is no specificity regarding evaluation of volunteers from group 2, their evaluation can take place at any time.

Eligibility criteria:
inclusion criteria : group 1 - patients : * give written inform consent * age ≥ 18 years * affiliate to social security system * ability to speak, understand and read french * breast cancer, stage ii or iii, treated by taxane-based chemotherapy group 2 - control group : * give written inform consent * age ≥ 18 years * affiliate to social security system * ability to speak, understand and read french exclusion criteria: group 1 - patients : * \< 18 years old or patients ≥ 18 years old under guardianship, or supervision * psychiatric, musculoskeletal or neurologic disorders * patients presenting one of the following contraindications to transcranial magnetic stimulation : * presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.) * history of epilepsy * brain injury (vascular, traumatic, tumour-induced, infectious or metabolic) * women that are pregnant * serious or recent heart disease group 2 -control group : * \< 18 years old or patients ≥ 18 years old under guardianship, or supervision * psychiatric, musculoskeletal or neurologic disorders * pacemaker implantation * history of cancer * all known chronic disease * subjects presenting one of the following contraindications to transcranial magnetic stimulation : * presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.) * history of epilepsy * brain injury (vascular, traumatic, tumour-induced, infectious or metabolic) * women that are pregnant * serious or recent heart disease
interaction between psychological states and caregiver's responses on pain in patients suffering from chronic pain

Conditions: Chronic Pain

Summary: chronic pain is a major cause of disability, and given its negative impact on the functional, psychological, and social well-being of sufferers, it is crucial to identify the biopsychosocial factors that influence it. while biological and psychological factors have been extensively studied, the role of the patient's relational context has not been thoroughly investigated to date. the presence of pain affects both directly and indirectly the patient's family and social context, which could significantly influence the perception of pain itself. in particular, partners of chronic pain patients may experience high levels of stress, anxiety, and worry, and this may have an impact on couple satisfaction and the type of partner's responses with respect to the patient's pain manifestations. it is conceivable that the type of interaction between patient and partner is influenced by the intersection of the ways in which the patient expresses pain, such as by manifesting catastrophic experiences, with the type of responses provided by the partner, such as of criticism, distraction, or support. it can be hypothesized that both the partner's actual responses to the patient's manifestations of pain and the patient's satisfaction with these responses are important. this study therefore aims to understand the relationships between these factors. specifically, it will assess whether attributions and catastrophizing behaviors of the patient influence pain intensity and interference over time through mediation by the responses given by the partner. it will also be assessed whether this mediation is moderated by the patient's satisfaction with the partner's responses.


Eligibility criteria:
inclusion criteria: * medical diagnosis of condition associated with chronic pain * presence of a caregiver associated by kinship and living together for at least six months * having given written consent at the time of treatment received at one of the ous involved in the project to the possibility of being contacted to participate in research for scientific purposes. exclusion criteria: * patients diagnosed with psychosis, dementia, or psychiatric comorbidities * patients who, at the time of recruitment, will be hospitalized or who will be undergoing inpatient rehabilitation treatment or who will have a scheduled surgery to be performed during the study period
pharmacodynamic trial on rocuronium in obese patients

Conditions: Bariatric Surgery

Summary: aim: to optimize the use of rocuronium (a neuromuscular blocking agent) in obese patients undergoing gastric bypass or gastric banding. background: during general anaesthesia, a neuromuscular blocking agent is needed to allow surgery and airway management. optimal dosing is important in order to avoid inadequately muscle relaxation, but also to avoid overdosage, which can result in prolonged anaesthesia and respiratory complications. main hypothesis: rocuronium dosed according to ideal body weight results in shorter duration of action compared to rocuronium dosed according to corrected body weight without prolonged onset time or compromised airway management or surgical demands for muscle relaxation.


Eligibility criteria:
inclusion criteria: * age 18-65 years. * elective laparoscopic gastric banding or gastric bypass. exclusion criteria: * expected difficult endotracheal intubation based on anatomic or pathologic findings or history. * known or suspected neuromuscular disease, known to affect the neuromuscular blockade. * severely impaired renal or hepatic function, as evaluated by the investigator. * known or suspected allergy to drugs used in the trial. * daily or expected use during the trial of the following drugs, known to affect neuromuscular transmission: inhalational anaesthetics, magnesiumsalts, clindamycin, polymyxins and aminoglycosides (gentamicin, neomycin, netilmicin, streptomycin og tobramycin).
quantificational enhancement pattern analysis using a novel software "vuebox" of contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis between adenomas and cholesterol polyps

Conditions: Gallbladder Polyp

Summary: the investigators' study is a prospective study to evaluate the enhancement pattern of contrast-enhanced endoscopic ultrasonography and suggest the criterions for differential diagnosis between gallbladder polyps by using software program of quantitative analysis.


Eligibility criteria:
inclusion criteria: * patient who will be received the exams to evaluate the polyps for treatment plan of surgical treatment * have a plan to evaluate by eus * 19 years of age or older exclusion criteria: * difficult undergo eus, * allergy for contrast agent, * renal failure, * acute coronary syndrome * pulmonary hypertension, 6) pregnancy

Keywords: quantitative analysis contrast enhanced endoscopic ultrasonography
zinc pneumonia outpatient trial in children < 2 years

Conditions: Pneumonia

Summary: the purpose of this study is to determine whether zinc can be used in combination with standard antibiotics to reduce the duration of illness and the likelihood of treatment failure among children less than two years old who have non-severe, outpatient pneumonia.

this study is a follow up to an earlier study among hospitalised children less than two years old with severe pneumonia who were administered zinc as an adjuvant along with standard antimicrobial agents. that study found a 20% reduction in illness duration and hospitalisation, as well as a 3 - 9 fold reduction in treatment failure for children given zinc along with standard antimicrobial management. however, since most pneumonia is managed in an outpatient setting, it is important to know if it works in this setting as well. we hypothesise that zinc may act as an acute phase reactant in the early stages of outpatient non-severe pneumonia to reduce both the duration of illness and the likelihood of treatment failure. to test this, we will randomise children less than two years old to receive either zinc or placebo can as an adjuvant to standard oral antimicrobial agents in the acute treatment of non-severe pneumonia in an outpatient urban setting. oral antibiotics will be given for a standard five-day course, while zinc (20 mg) or placebo will be administered once-daily for 10 days. patients will be followed up on a daily basis at home to monitor their progress and document compliance. outcomes will be a comparison between zinc and placebo groups on duration of illness, as measured by specific signs of pneumonia, and treatment failure, as measured by change of antibiotics or hospitalisation for failure to improve or worsening condition.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pneumonia exclusion criteria: * wheezing at presentation history of chronic lung, heart or other system disease suspected tuberculosis, active measles, severe malnutrition requiring hospitalisation, signs of systemic illness (sepsis, meningitis), those who have already received zinc/placebo supplements during this study, those known to be pre-treated with antibiotics prior to presenting to clinic

Keywords: pneumonia zinc treatment efficacy children
early functional outcomes after closed reduction with pinning versus open reduction internal fixation of wrist fractures

Conditions: Wrist Fractures

Summary: the purpose of this study is to compare early return to function in patients treated with closed reduction percutaneous pinning and open reduction internal fixation in displaced fractures of the distal radius. hypothesis: wrist range of motion, grip strength and outcome at 2-3 months after injury are better in patients treated with open reduction, internal fixation (orif) than in patients treated with closed reduction percutaneous pinning techniques (crpp). in addition patients treated with orif return to work at faster rates.


Eligibility criteria:
inclusion criteria: * 18 years or greater * patient functions independently * dorsally displaced, extra-articular fracture (colles' fracture); or simple intra-articular fracture with a single split between the scaphoid and lunate facets. * isolated injury (no other injuries). * one of the following criteria: substantial initial displacement * greater than 20 degrees dorsal angulation of the articular surface on the lateral view. * greater than 100% loss of apposition. * greater than 5 millimeters of shortening by ulnar variance on the posteroanterior radiograph. * greater than 2 millimeters articular incongruity (step or gap). * both dorsal and volar comminution. inadequate initial manipulative reduction * greater than 5 degrees of dorsal angulation of the articular surface on the lateral radiograph. * greater than 3 millimeters of radial shortening by ulnar variance on the posteroanterior radiograph. * greater than 2 millimeters articular incongruity. * bayonett apposition of the volar cortex. * less than 15 degrees of ulnarward inclination of the articular surface in the posteroanterior radiograph. loss of reduction within 3 weeks of injury. * any of the following changes in alignment from the initial post- reduction radiographs qualify: * 5 degrees or greater loss of palmar tilt of the articular surface on the lateral radiograph. * 2 millimeters or greater loss of radial height by ulnar variance on the posteroanterior radiograph. * 5 degrees or greater loss of ulnarward inclination of the articular surface of the distal radius on the posteroanteriorradiograph. * 2 millimeters or greater articular incongruity. exclusion criteria: * more complex articular fractures (i.e. anything more than a simple sagittal split between the scaphoid and lunate facets). * volarly displaced fractures. * infirm patients. * patients that rely on others for basic functional activities. * open fractures * fractures associated with neurovascular injury. * fractures associated with major head, neurological, or visceral injuries that will inhibit the ability to participate in a structured exercise program. * associated musculoskeletal injuries to the same arm.

Keywords: return to work crpp orif distal radius