Kornimate/medical-research-clean huggingface dataset:
diagnostic accuracy of urine flow cytometry in excluding bacteruria

Conditions: Acute Infection

Summary: a more rapid test for bacteriuria is desired. this will exclude the patients not having bacteriuria, which will contribute to a more rapid and accurate diagnosis of infectious diseases. the aim of the study is to investigate the diagnostic accuracy of point-of-care urine flow cytometry on diagnosing and excluding bacteriuria

a prerequisite for the appropriate use of antibiotics is timely access to accurate diagnostic tests, since treatment of acute infections should be initiated within a few hours to avoid serious complications such as bacteremia, sepsis, organ failure, septic shock and death. the diagnosis of urinary tract infections including acute pyelonephritis (apn) is difficult due to often weak and non-specific symptoms and high incidence of asymptomatic bacteruria in especially elderly patients. the diagnosis is verified by significant bacteriuria in urine culture. unfortunately, the time from urine sample to result from urine cultures is more than 24 hours days. urine test strips are unreliable with low specificity and low predictive values. therefore, a point-of-care (poc) test is desired, which can provide rapid results and quickly identify a bacteriuria. one such tool may be urine flow cytometry (ufc), which has shown promising diagnostic value for the exclusion of bacteriuria with a high negative predictive value. however, better documentation for its use as an ed diagnostic screening method is needed. the aim of the study is to investigate the diagnostic accuracy of poc-ufc on diagnosing and excluding bacteriuria? our hypothesis is that by excluding patients not having bacteriuria, it will contribute to a more rapid and accurate diagnosis

Eligibility criteria:
inclusion criteria: * suspicion of acute infections assessed by the receiving physician at the emergency department exclusion criteria: * if the attending physician considers that participation will delay a life-saving treatment or patient needs direct transfer to the intensive care unit. * admission within the last 14 days * verified covid-19 disease within 14 days before admission * pregnant women * severe immunodeficiencies: primary immunodeficiencies and secondary immunodeficiencies (hiv positive cd4 \ 20 mg/day prednisone or equivalent for \>14 days within the last 30 days), chemotherapy within 30 days)

Keywords: emergency department acute infections bacteruria urinary tract infections diagnosis
improving covid-19 vaccine uptake among black and latino youth

Conditions: COVID-19

Summary: black and latino youth may be less likely to get the covid-19 vaccine than white youth. in this study we will work with community members to come up with ways to help black and latino families learn more about the covid-19 vaccine and get the covid-19 vaccine. we will test these ideas out in pediatric primary care clinics. this study will help us make sure that all youth have an equal chance of getting the covid-19 vaccine.


Eligibility criteria:
inclusion criteria: * youth 0-21 years of age and their caregiver * receiving care at one of four nemours primary care practices selected for this study exclusion criteria: * none

Keywords: healthcare disparities vaccine hesitancy
role of sildenafil citrate in patients with unexplained recurrent miscarriages

Conditions: Recurrent Miscarriage

Summary: the purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages


Eligibility criteria:
inclusion criteria: * age 18-35 years * three or more recurrent miscarriages before the 24th week of gestation with no apparent cause for their previous losses * three or more months have elapsed since the last abortion * postmenstrual period * no other therapy allowed during our treatment course exclusion criteria: * concomitant use of organic nitrites, or nitrates * severe hepatic, renal, or cardiovascular impairment * history of stroke or myocardial infarction * patients with retinitis pigmentosa.

Keywords: sildenafil citrate doppler ultrasonography nitric oxide total antioxidant capacity
physical activity on eye hand coordination post strabismus surgery

Conditions: Coordination Impairment

Summary: the aim of this study is to determine the effect of physical activity on eye hand coordination in patient with amblyopia after strabismus surgery.

eye hand coordination is essential to many of everyday activities. strabismus not only affect vision but also affect eye hand activities and coordination. through this study the patients will apply physical therapy sessions to improve eye hand coordination for strabismus amblyopic patient.

Eligibility criteria:
inclusion criteria: * patients are both males and females. * their age will range from (10-14) years. * patients received strabismus operation. * patients are suffering from strabismic amblyopia * patients are suffering from eye hand coordination problems * patients will begin the training program after 2 months of operation. * all types of strabismus surgery will be included. exclusion criteria: * patient who didn't complete the physiotherapy training program for 3 months. * muscular disorders that will impair performance during training. * any organic lesion in the eye. * neurological disorders. * malignant conditions. * psychiatric illness, severe behavior or cognitive disorders. * children who can't understand the therapist's instructions and orders * amblyopia which is not related to strabismus condition .

Keywords: amblyopia strabismus physical therapy exercises eye hand coordination
acupuncture for hot flushes in menopause

Conditions: Menopause; Hot Flashes

Summary: in a pragmatic study investigate whether traditional chinese medicine acupuncture-care decreases the frequency of hot flushes and increases health related quality of life among postmenopausal women. the intervention group will receive 10 sessions of acupuncture, the control group will engage in self care only. the study period lasts for 12 weeks.

the study objective is to determine whether traditional chinese medicine (tcm) acupuncture-care together with self-care is more effective than self-care alone, to relieve climacteric complaints among women who seek alternatives to hormonal replacement therapy (hrt). study design is a pragmatic randomised controlled trial with two parallel arms. study participants are postmenopausal women who document a mean value of 7 flushes/24 hours and who are not using hrt or other prescribed medication that may influence climacteric complaints. the treatment group will receive 10 sessions of tcm acupuncture-care and self-care; the control group will engage in self-care only. the duration of intervention period is 12 weeks with evaluations at baseline, 4, 8, 12 weeks, and follow up at 6 and 12 months after baseline. primary endpoint is change in daily hot flush frequency in the two groups from baseline to 12 weeks; secondary endpoint is health related quality of life. n in each treatment group: 143 (286 altogether).

Eligibility criteria:
inclusion criteria: * postmenopausal women (at least one year past the last menstrual period) who are willing to receive acupuncture and who during two weeks of self-completed diaries10 document a mean value of 7 flushes/24 hours or more (or 50 flushes or more over a period of seven consecutive days), will be randomized after a baseline evaluation. * current users prescribed medications that influence hot flush rate (e. g. hrt, ssri's) can be included after a washout period. the washout-periods are eight weeks for ssri's and systemic (including transdermal) hrt and four weeks for local estradiol preparations exclusion criteria: * surgical menopause * history of cancer within the past five years * use of anticoagulant drugs * heart valve disease * poorly controlled hypertension * hypothyroidism * hyperthyroidism or diabetes mellitus * organ transplant * mental disease * overt drug or alcohol dependency * inability to complete study forms

Keywords: women acupuncture menopause hot flashes health related quality of life
efficiency, predictability and security of the trans-epithelial photorefractive keratectomy

Conditions: Myopia

Summary: the photorefractive keratectomy was the first correction mode refractive laser. it's a photo-ablation of a predetermined thickness of anterior corneal stroma. debridement of epithelium can be done either mechanically (m-prk) or by laser (trans-prk). trans-prk has a lot of interests: facility and speed of procedure as well as suppression of human variable. very good results are obtained by m-prk. the aim of this study is to show equivalence or non inferiority of trans-prk over conventional m-prk in terms of safety and refractive efficiency


Eligibility criteria:
inclusion criteria: * patients with stable refractive error (more than 2 years) * myopia up to -4.00 diopters and astigmatism up to -3.00 diopters exclusion criteria: * phototherapeutic keratectomy (ptk)
yoga for chronic low back pain and its mechanism of action: impact of strength and stretch (yoma ii)

Conditions: Chronic Low Back Pain

Summary: this study is a pilot, randomized controlled trial to provide feasibility and conduct preliminary analyses on physical (strength and stretch) mechanisms associated with a yoga intervention for non-specific chronic low back pain (clbp). recent large-scale trials have demonstrated the efficacy of a yoga intervention for clbp however, many types of yoga classes are available to the public and a specialized yoga protocol for individuals with clbp is needed. this study's goal is to quantify trunk strength and flexibility to better understand how these potential physical mechanisms specifically lead to improvement in pain-related outcomes including pain and disability. this knowledge will be used to design a large scale trial of mechanisms of yoga for clbp. for this pilot study, 40 participants will be randomized to either a yoga intervention (n=20) or to a usual care group (n=20) that will receive the back pain helpbook, a mind-body self-care program for better living. the yoga intervention will be offered weekly yoga classes and instructional materials will be provided for home practice.


Eligibility criteria:
inclusion criteria: * chronic low back pain lasting \> 6 months * back pain that is rated at least 3 on a numeric pain rating scale that ranges from 0 to 10 (0-no pain, 10 worst pain imaginable). * english language fluency exclusion criteria: * bmi \> 40 * inability to provide informed consent * recent diagnosis of abdominal aneurism * recent diagnosis of metastatic cancer * recent diagnosis of discitis * recent diagnosis of disk disease * recent diagnosis of spinal stenosis * recent diagnosis of spondylolisthesis * recent diagnosis of infectious cause of back pain * recent diagnosis of fracture of vertebra * recent diagnosis of fibromyalgia * recent diagnosis of rheumatoid arthritis * recent diagnosis of ankylosing spondylitis * recent diagnosis of paralysis * pregnancy * prior or planned back surgery * blindness or severe vision problems * deafness or severe hearing problems * bipolar or manic depression and not taking medication * major depression * psychoses (major) * a substance abuse condition * dementia * unable to get up and down from the floor * involvement in a lawsuit related to back pain * lack of transportation * other disabling chronic conditions (e.g., disabling heart or lung disease, diabetic neuropathy, receiving treatment for hepatitis) * currently (within the past 3 months) using yoga classes for more than 15 minutes per week * inability to be contacted by phone or email * no computer access * schedule does not allow for participation in classes/home practice * planning to move out of town or take a long vacation during the period of the study
clofarabine-melphalan-alemtuzumab conditioning in patients with advanced hematologic malignancies

Conditions: Advanced Hematologic Malignancies; Leukemia; Preleukemia

Summary: this is a clinical research study designed to evaluate whether a conditioning regimen consisting of the combination of three drugs named melphalan, alemtuzumab and clofarabine supported by donor blood cells will result in rapid recovery and a high rate of long-lasting remissions in patients with leukemia, lymphoma and myeloma.


Eligibility criteria:
inclusion criteria: * relapsed or refractory acute myelogenous or lymphoid leukemia * chronic myelogenous leukemia in accelerated phase or blast-crisis * chronic myelogenous leukemia in second or subsequent chronic phase * recurrent or refractory malignant lymphoma or hodgkin's disease * multiple myeloma at high risk for disease recurrence * chronic lymphocytic leukemia, relapsed or with poor prognostic features * other myeloproliferative disorder (polycythemia vera, essential thrombocythemia, myelofibrosis) with poor prognostic features * myelodysplastic syndromes (including pnh) with \> 5% blasts * zubroid performance status \< 2 (see appendix b) * life expectancy is not severely limited by concomitant illness * adequate cardiac and pulmonary function. patients with decreased lvef or pfts will be evaluated by cardiology or pulmonary prior to enrollment on this protocol * calculated creatinine clearance \> 50 ml/min * serum bilirubin 2.0 mg/dl, sgpt \< 3x upper limit of normal * no evidence of chronic active hepatitis or cirrhosis * hiv-negative * patient is not pregnant * patient or guardian able to sign informed consent exclusion criteria: * clinical progression

Keywords: melphalan alemtuzumab clofarabine
study of the efficacy of gged: a cognitive training app for eating disorders.

Conditions: Eating Disorders

Summary: the aim of the present study is to evaluate the efficacy of ggtca to decrease the maladaptive beliefs associated with eating disorders (ed) in non-clinical adult population. specifically, a randomized controlled trial with crossover assignment design and two groups (experimental and control) will be carried out in adults aged 18-65 years to assess the changes pre and post use the app. it's expected that after the use of the ggtca app for 15 days are, at the primary level: decrease in the degree of ascription to dysfunctional beliefs associated with ed; and at the secondary level: increase in self-esteem; decrease in eating symptomatology; and no changes in emotional symptomatology, since the pilot study did not find. these results are also expected to be maintained in subsequent follow-ups, at 15 days and a month after to finish the app in experimental group, and 15 days after to finish the app in control group.

there is a digital platform called ggtude, which is composed of different modules, each of them aimed at working with different mental health problems. the goal is to provide an easy-to-use tool as a cbt complement to work on the self-dialogue that relates to the core beliefs associated with the psychological problem in particular. to achieve this target, a cognitive training exercise is performed: different sentences appear in the form of beliefs, and the person must identify and accept those beliefs that are functional, adaptive and positive, dragging them to the lower part of the screen; and reject those that are dysfunctional, maladaptive and negative dragging them to the upper part of the screen. there are different modules, for example, to work self-esteem, depression, body image or obsessive-compulsive disorder, that have proven their effectiveness.

Eligibility criteria:
inclusion criteria: * ages between 18 and 40. * have a dispositive with internet access. exclusion criteria: * none.

Keywords: maladaptive beliefs cognitive therapy mobile app apps e-health non-clinical population
virtual bronchoscopy transbronchial needle aspiration(tbna): a proof of concept study

Conditions: Lung Cancer

Summary: the purpose of this study is to determine wether ct-pet virtual bronchoscopy guided transbronchial needle aspiration is suitable for the investigation of mediastinal lymph nodes which is needed for correct staging of lung cancer.

accurate staging of mediastinal lymph nodes (mlns) in patients with lung carcinoma (lc) is paramount as the n stage largely determines treatment strategy, prognosis and outcome. surgical staging such as mediastinoscopy is considered the gold standard. a less invasive alternative is transbronchial needle aspiration (tbna). this technique is limited however by moderate and operator dependent accuracy. recently less invasive strategies such as esophageal ultrasound guided fine needle aspiration (eus-fna) and endobronchial ultrasound guided tbna (ebus-tbna) were introduced. these strategies have largely complemented tbna and surgical staging, with high accuracy and low morbidity. disadvantages compared to tbna however are required specific expertise, higher equipment and maintenance costs, the need for more assisting personnel and the need for sedation. advances in computer generated image processing based on available ct and pet images enable (quasi) real-time virtual bronchoscopy that can assist minimal invasive surgical performance including bronchoscopy. optimizing the traditional tbna procedure with these modern imaging techniques might be equally accurate and more cost effective.

Eligibility criteria:
inclusion criteria: * age \> 18 years * proven or suspected lung cancer, base on clinical picture and/or ct-pet findings * suspected involvement of mediastinal lymph nodes on ct-pet scan * written informed consent exclusion criteria: * none

Keywords: lung cancer mediastinal lymph nodes tbna staging lung cancer
use of preoperative and postoperative antimicrobial treatment

Conditions: Ear Infection Bacterial; Surgical Site Infection; Antibiotic Side Effect

Summary: in this study, patients undergoing ear surgery (cochlear implantation, stapedotomy, tympanoplasty) will be randomized to one of two antibiotic treatment groups. one group will receive a single treatment with an antibiotic at induction the other group will receive the single intravenous treatment, plus a one week course or oral antibiotic

1. patients will be asked to participate in the study. 2. randomization 3. surgery 4. follow-up at 1 week, 1 month patients will be asked if they filled their prescription, took the medication as prescribed, experienced any symptoms such as rash, diarrhea, nausea,.. further the wound will be inspected for any signs of infection. patients will also be asked if they had noticed discharge, pain, pulsating sensation 5. follow-up at three months, 1 year and 2 years - patients will again be asked for any signs of infections or necessary visits with their doctor due to infections

Eligibility criteria:
inclusion criteria: * willing to participate in the study * undergoing standard ear surgery (stapedotomy, cochlear implantation, tympanoplasty and tympanomastoidectomy) exclusion criteria: * multiple allergies to antibiotic substances * therapy with an antibiotic substance within the last 6 weeks * prior radiation to the head and neck patients undergoing revision surgery * any use of post-operative antibiotics (oral, intravenous, topical) for reason which do not include surgical site infection
assessment of hepatic fibrosis by shear wave elastography in patients with liver malignancy: a prospective single-center study

Conditions: Liver Tumor; Hepatic Fibrosis

Summary: to evaluate the diagnostic performance of two-dimensional shear-wave elastography (swe) for staging hepatic fibrosis in the background liver parenchyma in patients with liver tumors before hepatic resection, using resected tissue pathology as a reference standard.


Eligibility criteria:
inclusion criteria: * (i) patients with a solid focal liver lesion that was pathologically proven or diagnosed by imaging methods such as conventional us, ct or mr imaging; (ii) patients scheduled to undergo a hepatectomy; (iii) patients with a lesion ≥1.0 cm in diameter. exclusion criteria: * (i) patients with a history of chemotherapy; (ii) patients unable to properly hold their breath.

Keywords: shear-wave elastography hepatic fibrosis liver tumor
fecal microbiota transplantation in patients with ulcerative colitis

Conditions: Ulcerative Colitis

Summary: the purpose of this study is to find out whether a single fecal microbiota transplantation is an effective and safe treatment as an adjunct to standard therapy in patients with ulcerative colitis.


Eligibility criteria:
inclusion criteria: * active ulcerative colitis (pucai 10-64) in whom fecal microbiota transplantation via colonoscope can be performed exclusion criteria: * severe ulcerative colitis (pucai \> 65)
choice: changes to treatment and outcomes in patients with type 2 diabetes initiating injectable therapy

Conditions: Type 2 Diabetes Mellitus

Summary: patients initiating injectable therapy for type 2 diabetes (insulin or exenatide) in usual clinical practice will be enrolled and followed up for two years in order to describe actual practice with regards to the time on initial treatment regime, whether treatment regimens are being modified, what treatment modifications are made, and clinical and patient-reported outcomes.


Eligibility criteria:
inclusion criteria: * are aged 18 or above * diagnosed with type 2 diabetes * have had a treatment decision made within the normal course of care to initiate either insulin or exenatide for the treatment of type 2 diabetes * have not previously been treated with either insulin or exenatide * are not simultaneously participating in another study which includes an investigational drug or procedure at study entry * have been fully informed and given their written consent for use of their data * have sufficient understanding of the primary language of their country such that they will be able to complete the questionnaires.

Keywords: diabetes insulin exenatide byetta amylin lilly
intratumoral cavatak (cva21) and pembrolizumab in patients with advanced melanoma (vla-011 capra)

Conditions: Melanoma

Summary: this study will employ a phase ib design using the established dose of cavatak with pembrolizumab in subjects with advanced melanoma for whom pembrolizumab would be considered standard of care. our hypothesis is that oncolysis of melanoma cells by cavatak will be important in amplifying the t-cell potentiating effects of pembrolizumab.


Eligibility criteria:
inclusion criteria: * subjects with metastatic or unresectable stage iiib/c of iv melanoma for whom treatment with pembrolizumab is indicated and who have at least one cutaneous, subcutaneous tumor or palpable lymph node amenable to intratumoral injection. * at least one tumor must qualify to be an index lesion for modified who criteria. * subjects must have adequate hematologic, hepatic and renal function. * ecog performance status of 0 or 1. * anticipated lifespan greater than 12 weeks exclusion criteria: * ocular primary tumors. * presence of any central nervous system tumor that has not been stable for at least 4 weeks off corticosteroids. * tumors lying in mucosal regions or close to an airway, major blood vessel or spinal cord. * subjects with active, known or suspected autoimmune or immunosuppressive disease. * subjects previously treated with cva21. * subjects requiring systemic treatment with corticosteroids or other immunosuppressive medications within 14 days prior to the first treatment. * subject has received chemotherapy within the last 4 weeks prior to first treatment. * clinically significant cardiovascular disease. * females of childbearing potential must have negative serum or urine pregnancy test. * subjects requiring or using other investigational agents while on treatment in this trial. * history of other malignancy within the last 3 years (with exceptions). * active infection requiring systemic therapy. * known history of hiv disease, active hepatitis b or hepatitis c. * history or evidence of other clinically significant disorders that would pose a risk to subject safety. * inability to give informed consent and comply with the protocol.

Keywords: pembrolizumab coxsackievirus a21 melanoma cavatak cva21 checkpoint inhibitor