Kornimate/medical-research-clean huggingface dataset:
photodynamic lasertherapy (pdt) in periodontal treatment (in vivo)

Conditions: Periodontal Disease

Summary: the purpose of the study is to evaluate the effect of the photodynamic therapy in periodontal patients

the purpose of the study is to evaluate the effect of the photodynamic therapy in periodontal pockets and to assess the reduction of subgingival bacteria. the first step will include the evaluation of the quantity of the light which will activate the photosensitizer in the various niches in the periodontal pocket. the second step will evaluate the distribution of the photosensitizer in the periodontal pocket. the third step will assess the woundhealing of the the photodynamic therapy compared to conventional periodontal therapy with an ultrasonic device.

Eligibility criteria:
inclusion criteria: * systemic healthy * \>15 teeth * ≤ 6 mm \>2 teeth * age \> 35 years exclusion criteria: * - systemic ill * cardiac pacemaker * \< 15 teeth

Keywords: photodynamic lasertherapy periodontol disease
embryo implantation after induced endometrial injury

Conditions: Sterility

Summary: some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure. the purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing ivf

endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. the mechanisms that induce that improvement remain unknown. we want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques. for that purpose we will start a randomized controlled trial with the ideal background in implantation in art, the egg donation programme.

Eligibility criteria:
inclusion criteria: * 19-44 aged women * 19-29.9 kg/m2. * 1st or 2nd fresh embryo transfer ( egg donation). * 1 or 2 blastocysts available. * written agreement. * \> or = 6 mms endometrial thickness. exclusion criteria: * premature ovarian failure. * endometrial pathology. * insufficient endometrial development. * hydrosalpinx * mullerian malformations.

Keywords: scratching endometrial biopsy ongoing embryo implantation assisted reproductive techniques
comparison between high-flow nasal cannula system and non-invasive ventilation in acute hypoxemic respiratory failure

Conditions: Acute Hypoxemic Respiratory Failure

Summary: acute hypoxemic respiratory failure may require invasive mechanical ventilation. however, invasive mechanical ventilation is associated with a variety of complications. non-invasive ventilation has been presented as an alternative treatment but controversy remains. the investigators hypothesize that high-flow nasal cannula system is effective enough to prevent intubation in acute hypoxemic respiratory failure and not inferior to non-invasive ventilation.


Eligibility criteria:
inclusion criteria: * age above 18 * patients with acute hypoxemic respiratory failure exclusion criteria: * age \< 18 years * hypercapnia (arterial carbon dioxide tension (paco2) \>45mmhg) at admission * need for emergency intubation, including cardiopulmonary resuscitation * recent esophageal, facial or cranial trauma or surgery * severely decreased consciousness (glasgow coma score \<11) * cardiogenic shock or severe hemodynamic instability * systolic blood pressure \<90 mmhg associated with decreased urinary output(\<20 ml.h-1) despite fluid repletion and use of vasoactive agents * lack of co-operation * altered mental status with decreased consciousness and/or evidence of inability to understand or lack of willingness to co-operate with the procedures * tracheotomy or other upper airway disorders * severe ventricular arrhythmia or active myocardial ischemia * active upper gastrointestinal bleeding * inability to clear respiratory secretions * more than one severe organ dysfunction in addition to respiratory failure

Keywords: respiratory failure
recurrent acute myocarditis registry

Conditions: Myocarditis; Cardiomyopathy

Summary: the association between myocardial inflammation (clinically represented by acute myocarditis episodes) and the later development of an arrhythmogenic cardiomyopathy is widely elusive.

acute myocarditis (am) is an inflammatory disease of the myocardium caused by different infectious and non-infectious triggers. it is a major cause of sudden cardiac death, with also long-term adverse outcomes in survivors. the incidence and predictive factors of recurrent am (ram) are unknown. arrhythmogenic cardiomyopathy (acm) is a genetically-determined or acquired arrhythmogenic disorder of the myocardium. with an incidence of 1/5000, genetic acm is the consequence of pathogenic variants in genes encoding for desmosomal and cytoskeleton proteins. originally described as a right ventricular disease (arvc), genetic acm is increasingly recognized as a left (alvc) or biventricular entity. genetic acm may manifest with various clinical presentations, with a predisposition to acute and chronic heart failure, ventricular arrhythmias and sudden cardiac death. pathophysiology of genetic acm at early stages remain widely elusive. myocardial inflammation has been consistently reported in patients with genetic acm, but the exact nature of their association is a matter of debate. the temporal association between ram episodes and the later diagnosis of genetic acm is speculative, and it has been hypothesized recently that ram episodes might reflect early active phases in the development of a genetic acm. the investigators aim to study the temporal association between ram episodes and the later diagnosis of an acm. consecutive patients with at least two episodes of am and referred to a tertiary university referral center (pop. 1.500.000 inhabitants) for clinical expertise, follow-up and etiological work-out were prospectively included in this registry.

Eligibility criteria:
inclusion criteria: patients with at least two episodes of acute myocarditis as defined by the european society of cardiology diagnostic criteria.

Keywords: recurrent acute myocarditis myocardial inflammation arrhythmogenic cardiomyopathy
prediction and prevention of nocturnal hypoglycemia in persons with type 1 diabetes using machine learning techniques

Conditions: Type1diabetes; Hypoglycemia

Summary: the objective is to develop a novel system to predict and prevent nocturnal hypoglycemia in type 1 diabetic (t1d) patients, focused in patients with multiple daily injections (mdi) therapy. the general idea is to make use of previous-day information in the moment when patients go to sleep, and then predict if in the next following hours any hypoglycemic event will occur. if the system will have predicted any hypoglycemic event in that moment, it is expected that it will be able to warn the patient to take some action: such as reduce basal insulin dose or to consume a snack before sleep. 10 patients with t1d for more than five years will be included. it is a longitudinal, prospective, interventional study in which every patient will use intermittently scanned continuous glucose monitoring (iscgm) and a physical activity tracker during 12 weeks. moreover, during this period, patients will store in a mobile application (freestyle librelink) or in a reader information regarding their diabetes management activities, such as insulin delivery doses and meal consumption.


Eligibility criteria:
inclusion criteria: * patients \> 18 years with type 1 diabetes: * \> 4 hypoglycemia / week (\< 70 mg/dl, including day and night), last 2 weeks and / or * one severe hypoglycemia during the last year and / or * hypoglycemia unawareness (clarke test \>3) * disease duration \> 5 years * on multiple doses of insulin (mdi) therapy using a rapid acting insulin analogue as prandial insulin (lispro, aspart or glulisine) and any basal analogue as basal insulin. * a1c 6.5 - 9.5 % * able to use an intermittently scanned continuous glucose monitoring (iscgm) system. * performing \>4 self-monitoring blood glucose (smbg) per day * using carb-counting * providing an informed consent * no cgm user previously (during the last 3 months). exclusion criteria: * patients with a previous diabetic ketoacidosis (dka) episode in the previous 6 months. * patients with a severe hypoglycemia in the previous 6 months. * severe diabetic complications or comorbidities: eye, renal, cardiovascular...from the clinicians point of view. * pregnancy and breastfeeding. * history of drug or alcohol abuse. * scheduled surgery during the study period. * mental conditions that prevent the subject to understand the nature, purpose and possible consequences of the study. * subjects those are unlikely to meet the clinical study protocol, eg uncooperative attitude, inability to return for follow-up visits, or poor probability of completing the study. * using an experimental drug or device during the past 30 days.

Keywords: type 1 diabetes intermittent continuous glucose monitoring hypoglycemia machine learning
a study to compare the nexgen cr and cr-flex knee implants

Conditions: Total Knee Arthroplasty; Osteoarthritis

Summary: the purpose of this study is to test for significant differences in functional outcomes, specifically pre-operative rom and post-operative rom obtained by using a nexgen cr versus a nexgen cr-flex knee implant. specifically, it is predicted that an increase in post-operative range of motion will be experienced by patients treated with the nexgen cr-flex knee implant.

this study will compare the clinical results of the nexgen cr femoral component with the higher flexion potential of the nexgen cr-flex femoral component in all patients with degenerative joint disease that require total knee arthroplasty. the primary variable of interest is post-operative range of motion achieved with the two devices, which are implanted with slightly different surgical techniques in patients who may also be subjected to different rehabilitation programs depending on the device they are assigned.

Eligibility criteria:
inclusion criteria: * age, 21-80 years * sex, male and females will be included * bmi less than or equal to 39 * stable health, the patient would be able to undergo surgery and participate in a follow-up program based on physical examination and medical history. * patient is willing and able to cooperate in follow-up therapy. * patient exhibits pre-operative radiographic evidenced of joint degeneration consistent with tka that cannot be treated in non-operative fashion. * patient has stable and functional posterior cruciate and collateral ligaments. * patient has potential to perform higher than average range of motion activities. * operative side range of motion flexion greater than or equal to 120 degrees. * severe knee pain and disability due to degenerative joint disease. * patient or patient's legal representative has signed the informed consent form. exclusion criteria: * previous history of infection in the affected joint. * previously failed knee endoprosthesis of any kind. * charcot joint disease or other severe neurosensory deficits. * previous patellectomy * patient is skeletally immature. * grossly insufficient femoral or tibial bone stock. * patient is pregnant. * varus or valgus deformity greater than 20 degrees. * fixed flexion deformity greater than 15 degrees. * previous high tibial osteotomy. * previous femoral osteotomy. * patient is a poor compliance risk, currently treated for ethanol or drug abuse, physical or mental handicap, etc. * loss of musculature or absence of musculoligamentous supporting structures required for adequate soft tissue balance.

Keywords: total knee arthroplasty osteoarthritis knee
simulation-based central venous line maintenance bundle education

Conditions: Central Line Infection

Summary: catheter associated blood stream infections (ca-bsi) remain a source of significant morbidity and mortality in adult and pediatric critical care units. while it has been established that cvl maintenance bundles are pivotal to achieving and maintaining low ca-bsi rates, training and retention of proper bundle compliance remains a challenge. the investigators prospectively compared this simulation-based program to a standard educational approach. the investigators hypothesized that implementation of bedside simulation-based training of cvl dressing changes by registered nurses would improve cvl maintenance bundle compliance.

the 2006 nachri quality transformation effort demonstrated that additional reduction in pediatric catheter associated blood stream infection (ca-bsi) rates could be achieved through improving compliance with maintenance bundle care for central lines. the investigators objective was to improve maintenance bundle compliance rates and nursing competency surrounding central venous line (cvl) care in their pediatric intensive care unit (picu). a multidisciplinary team developed a bedside simulation-based training program to improve compliance with standard picu cvl maintenance bundle. the investigators then performed a randomized comparison study comparing a standard cvl bundle education process for bedside picu nurses in a control group (cg) to an intervention group (ig) receiving bedside training to simulate a cvl dressing change and maintenance bundle followed by intermittent educational refresh. groups were assessed for compliance with prescribed components of the cvl bundle maintenance (cvl score). cvl scores will be compared between groups

Eligibility criteria:
inclusion criteria: * any nurse assigned to the picu on a regular basis was eligible to participate in the study, including full-time, part-time, and occasional (prn) picu nursing staff, as well as central staffing office (icu float nurses) and traveler nurses contracted to the picu for a minimum of 12 weeks exclusion criteria: * nurses floating from other units, agency nursing personnel, or traveler nurse contract of \< 12 week period were excluded. nurses on orientation were excluded until completion of introductory 6-month probation period

Keywords: simulation
haart annuloplasty device valve repair registry

Conditions: Aortic Valve Insufficiency; Aortic Aneurysm

Summary: multicenter us registry study to assess procedure success and long-term (10-year) performance of the haart 200 and haart 300 aortic annuloplasty devices when used during aortic valve repair in a routine cardiovascular practice setting.

the haart aortic annuloplasty devices are three-dimensional annuloplasty rings designed to be implanted intra-annularly in the aortic valve to correct annular dilatation and/or maintain annular geometry of the aortic valve in patients with trileaflet valve morphology (haart 300) or bicuspid valve morphology (haart 200) with moderate to severe aortic insufficiency who are undergoing aortic valve repair due to symptoms or as part of a repair for an aortic aneurysm. the study is a multicenter registry study enrolling both retrospective and prospective participants. investigators are cardiothoracic surgeons specializing in surgery of the aortic valve and aorta at facilities with suitable infrastructure to support collection of the registry study data. patients who underwent or will undergo aortic valve repair using either the haart 300 or haart 200 device will be enrolled. all patients known to have received the haart 300 or haart 200 device at participating centers will be contacted and offered the opportunity to enroll in this registry study. prospective participants will have evaluations prior to surgery, intraoperatively, immediately following surgery, at discharge (or within 90 days), and at 1, 3, 5, and 10 years. in addition to the follow-up clinic visits, phone contacts are scheduled at years 2,4,6, 7, 8, and 9 to maintain participant engagement as well as to ascertain if any safety events have taken place. retrospective participants who have already received the haart 300 or haart 200 device prior to study enrollment will undergo safety assessment at the time of enrollment in the study.

Eligibility criteria:
inclusion criteria: * the patient underwent or is undergoing aortic valve repair using either the haart 300 or haart 200 aortic annuloplasty device in accordance with the instructions for use. * the patient has reviewed and signed the written informed consent form. * the patient agrees to return for all follow-up evaluations for the duration of the study. exclusion criteria: * retrospective patient that has undergone a subsequent aortic valve replacement procedure.

Keywords: aortic valve repair aortic valve annuloplasty
annexin levels of periodontal inflammatory regulation

Conditions: Periodontal Diseases; Inflammation

Summary: anxa1, a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while anxa2 is involved in the initiation of the inflammatory responses. the aim of this study was to determine the effects of annexin family (anxa1 and anxa2) in periodontal disease.

healthy participants (n:25) and stage iii, grade b periodontitis (n:25) patients enrolled for this study. clinical periodontal parameters and pisa levels were noted. serum, saliva, and gcf samples were collected to measure the anxa1, anxa2 and il-1β levels.

Eligibility criteria:
inclusion criteria: systemically healthy * clinical diagnosis of periodontitis * clinical diagnosis of periodontal health exclusion criteria: * • history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months) * nonsurgical periodontal treatment (previous 6 months) * surgical periodontal treatment (previous 12 months) * presence of\<10 teeth * current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy) * diabetes * diagnosis of rheumatoid arthritis * pregnancy * lactating * smoking * excessive alcohol consumption.

Keywords: periodontal disease annexin
hyaluronic acid effect on xenogenic bone healing

Conditions: Bone Resorption; Tooth Loss

Summary: the aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation. following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.


Eligibility criteria:
inclusion criteria: * patients in need of tooth extraction and willing to receive dental implants in the extraction site * presence of two mono radicular teeth in need of extraction exclusion criteria: * patients with systemic diseases * patients under 8 years and above 60 years. * presence of endodontic or periodontal lesion in the extraction sites

Keywords: tooth extraction ridge preservation hyaluronic acid dental implant
risk management in interventional cardiology - a quality management single-center registry

Conditions: Cardiovascular Diseases

Summary: the validity and applicability of different clinical risk scoring models in a variety of settings of interventional cardiology is evaluated in a retrospective and continuing prospective single-center registry at university hospital düsseldorf. risk-adapted safety interventions are additionally tested.

beginning with a retrospective assessment of 2014-2017 and continuing with a prospective registry, clinical outcomes of interventional cardiac catheterization procedures at university hospital düsseldorf in a variety of settings (elective and emergency coronary procedures, structural and rhythmologic cardiac interventions etc.), will be evaluated. different risk scoring models are recommended for risk stratification by cardiovascular societies (e.g. grace, crusade, ncdr, acef, euroscore scores) and will be evaluated for their applicability to contemporary and local clinical practice in interventional cardiology. risk-adapted safety interventions (e.g. intensified monitoring, vascular access closure, renal protective measures) will be applied to all patients and will be evaluated for their impact on clinical outcomes.

Eligibility criteria:
inclusion criteria: * \>18 yeas of age, written informed consent, cardiac catheterization at university hospital düsseldorf, germany exclusion criteria: * no written informed consent

Keywords: risk score risk management ncdr interventional cardiology
instead trial: investigation of stent grafts in patients with type b aortic dissection

Conditions: Aortic Diseases

Summary: the objective of this study is to compare treatment with an endograft prothesis versus antihypertensive treatment in patients with a dissection of the thoracic aorta.

patients older than 18 years with type b aortic dissection as diagnosed by computed tomography or magnetic resonance angiography are randomized to either a thoracic aortic endoprosthesis and antihypertensive treatment, called "stent grafting," or a tailored antihypertensive treatment, called "medical treatment." only patients in a clinically stable condition and without spontaneous thrombosis of the false lumen after 14 days of the index dissection are considered eligible for study inclusion. primary outcome measure is all-cause mortality. secondary outcome variables include conversion to stent and/or surgery, induced thrombosis of the false lumen, cardiovascular morbidity, aortic expansion (\>5 mm/y of maximum diameter including true and false lumina), quality of life, and length of intensive care unit and hospital stay. the study design calls for 136 patients to be randomized and monitored for 24 months.

Eligibility criteria:
inclusion criteria: * no contraindication for an anesthetic procedure with intubation * type b aortic dissection that occurred 2-52 weeks before randomization * diameter of the targeted aortic segment ≤6 cm * aortic kinking \<75° * the subject or legal guardian understands the nature of the study and agrees to its provisions on a written informed consent form * availability for the appropriate follow-up visits during the follow-up period * capability to follow all study requirements exclusion criteria: * pregnant woman * thrombocytopenia or ongoing anticoagulation therapy * renal failure and/or creatinine \>2.4 mg% * complete thrombosis of the false lumen * ongoing infection * cancer is likely to cause death within 1 year * enrolment in another clinical study * unwillingness to cooperate with study procedures or follow-up visits

Keywords: aorta dissection thoracic