Kornimate/medical-research-clean huggingface dataset:
schistosomiasis in women of reproductive age in burkina faso: implications for control

Conditions: Schistosomiasis; Anaemia; Pregnancy

Summary: cross-sectional study of prevalence and intensity of schistosome infection in pregnant women, follow-up into postpartum, and the association of schistosome infection with haemoglobin concentration, compared to a group of non-pregnant women.

the objective of this study is to investigate the epidemiology of schistosomiasis and anaemia among pregnant and non-pregnant women in burkina faso and explore the implications for the national schistosomiasis control programme and future studies. specific objectives are: * to determine the prevalence and intensity of schistosome infection in pregnant women attending for antenatal care and in non-pregnant women of reproductive age in an area which is hyperendemic for s.haematobium infection and in which there is little or no s.mansoni infection * to determine the prevalence and intensity of schistosome infection in pregnant women attending for antenatal care and in non-pregnant women of reproductive age in an area in which s.mansoni infection is common * to determine haemoglobin concentration in pregnant women attending for antenatal care and in non-pregnant women of reproductive age in the regions described above * to investigate the association between infection and haemoglobin concentration in pregnant and non-pregnant women * to determine the prevalence of other parasitic infections in pregnant women and non-pregnant women including hookworms, ascaris, trichuris and malaria * to demonstrate the research team's ability to follow-up pregnant women recruited at antenatal care clinics onto the postpartum period

Eligibility criteria:
inclusion criteria: * pregnant women attending for anc * non-pregnant women age 15-45 years accompanying relatives or children to the health centres or for immunization

Keywords: schistosomiasis anaemia pregnancy
shoulder passive range of motion and positioning exercise on hemiplegic stroke patients

Conditions: Shoulder Pain; Hemiplegia; Stroke; Rotator Cuff Injury

Summary: several factors associated with the hemiplegic shoulder pain after stroke includes rotator cuff injury, bicipital tendonitis, impingement, spasticity, limited external rotation of shoulder joint, adhesive capsulitis, shoulder subluxation, shoulder hand syndrome, and brachial/axillary neuropathy. in this study, the investigators aim to usie high frequency ultrasound to evaluate the relationship between stroke patients with poor shoulder motor function and shoulder tendon injury. also, assumed that performing passive range of motion and positioning training might prevent tendon injury of shoulder and hemiplegic shoulder pain in either acute or chronic stage of stroke.

hemiplegic shoulder pain is a common complication. several factors associated with the hemiplegic shoulder pain includes rotator cuff injury, bicipital tendonitis, impingement, spasticity, limited external rotation of shoulder joint, adhesive capsulitis, shoulder subluxation, shoulder hand syndrome, and brachial/axillary neuropathy. flaccidity has a positive association with soft tissue injury or tendon injury of the shoulder. in the preliminary study, base on the sonography results, it is found that the possibility of getting tendon injury or inflammation on the affected shoulder joint is higher in the group of patients who were with worse motor functions during the rehabilitation in hospital. in this study, one hundred acute stroke patients with hemipelgia will be enrolled. and those participants would be separated into 2 groups: control group (brunnstrom stage iv-vi) and experimental group (brunnstrom stage i-iii). clinical characteristics and physical findings will be recorded on the admission date. during the process, the investigators will use high frequency (5-12 mhz) musculoskeletal ultrasound to evaluate those tendons around bilateral shoulder joints on the admission date and at 2 weeks later. in the first year after stroke, half patients in those 2 groups will perform positioning training and passive range of motion for affected shoulder either during hospitalization or after being discharged. then, the investigators will execute physical examination and use high frequency ultrasound to evaluate those tendons around bilateral shoulder joints of the participants twice after 6 months and 12 months. then, the investigators will discuss the incidences of shoulder tendon injury after receiving rehabilitation program according to ultra-sonographic findings.

Eligibility criteria:
inclusion criteria: * stroke with hemiplegia * age between 18-80 exclusion criteria: * recurrent stoke patient * previous history of shoulder pain, any injuries and operation in shoulder joint, frozen shoulder, tendinitis in shoulder joint, * any other systemic neuromuscular disease * cognition or language impairment leading to communication difficulty

Keywords: stroke hemiplegia rotator cuff injury
precision nutrition and food safety for dietary prevention of chronic disease study

Conditions: Chronic Diseases

Summary: the associations between food nutrition and safety factors with the risk of chronic diseases are still unclear. this study is conducted in jinhua, a city with a high prevalence of chronic diseases in china, to assess relations between food nutrition and safety factors and chronic diseases.

investigations of associations of food nutrition and safety factors with the risk of chronic diseases are limited and studies in china are still lacking. the investigators aim to collect basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors, and so on, to assess the association of food nutrition and safety factors including various food items, dietary fatty acids, and internal biomarkers of food contaminants such as acrylamide and 3-mcpd with various chronic diseases in a chinese middle-aged and elderly population. we will use multi-omics technology to investigate the causal mechanisms. results from this study will be valuable for chronic diseases prevention in china.

Eligibility criteria:
inclusion criteria: * subject aged ≥45 and ≤74 years old * subject has complete data on diet and follow-up time exclusion criteria: had the major illness that had made personal life disabled

Keywords: food safety food nutrition food contaminant mult-omics chronic diseases
phenomenology of anxiety in preschool children with asd

Conditions: Anxiety; Autism Spectrum Disorder

Summary: this study investigates the prevalence, phenomenology, and correlates of anxiety in preschool children with autism spectrum disorder (asd) across a two-year period. attention bias to threat, a potential objective marker of anxiety, also is examined using eye tracking methods.

anxiety disorders in children with autism spectrum disorders (asd) are one of the most prevalent and impairing co-occurring conditions, affecting approximately 40% of the population and causing major disruptions in school and family life. research in typically developing (td) children suggests that anxiety usually emerges in the preschool years (3-5 years) and can result in future psychopathology. early detection and treatment of childhood anxiety in children with asd can lead to improved clinical outcomes. this study assesses the prevalence and phenomenology of anxiety in preschool children with asd utilizing an established and comprehensive measure of anxiety in children with asd across three time points (baseline, one year post, two years post).it also investigates the association of child (e.g., asd features) and parent (e.g., mental health, caregiver strain) characteristics with anxiety cross-sectionally and longitudinally, to determine if certain correlates predict or maintain future anxiety. attention bias to threat stimuli and its physiological correlates are also examined as potential objective markers of anxiety using eye tracking and pupillometry methods.

Eligibility criteria:
inclusion criteria: * age 3 years 0 months to 5 years 11 months; * dsm-5 asd diagnosis based on clinical impressions and results of the autism diagnostic observation schedule-2 (ados-2) * child resides with at least one biological parent * parents are english speaking exclusion criteria: * history of psychological trauma * history of neurologic illness * parent substance abuse, bipolar disorder, psychosis * parents require support from a medical interpreter * child displays severe behavior challenges * severe eyesight or hearing impairments that may interfere with the protocols

Keywords: autism anxiety eye tracking preschool
observational avodart (dutasteride) study in benign prostatic hyperplasia subjects - oasis

Conditions: Prostatic Hyperplasia

Summary: this study was designed to assess the effectiveness of dutasteride in the actual clinical practice of prostate assessment clinics in the uk in accordance with best practice over a 12-month period.


Eligibility criteria:
inclusion criteria: * patients who not have received any pharmacological treatment or surgical interventions for bph (benign prostatic hyperplasia). * patients should be prescribed dutasteride in compliance with the uk smpc and baus guidelines on the treatment of bph. * patients must only enter the study after the decision to prescribe dutasteride has been undertaken. exclusion criteria: none specified

Keywords: avodart ipss bph dutasteride eq-5d observational
influencing factors of the corneal endothelial cell loss

Conditions: Cataract

Summary: this is a multi-center cohort study with prognostic aims to identify factors associated with endothelial cell loss during cataract surgery. patients will have their endothelial density measured by specular microscopy preoperatively, at 1 month and at 3 months after surgery. the rest of their management will be in line with standard practice.

cataract surgery is the most commonly performed surgical procedure worldwide. postoperative visual function depends on implant into the crystalline lens, retinal lesion, corneal damage or glaucomatous damage. moreover, preoperative corneal endothelial damage should be as low as possible to provide corneal transparency. indeed, the endothelium plays important role in maintaining corneal transparency. the loss rate of endothelial cell after cataract surgery ranges in the scientific literature from 8 to 15 %. severe endothelial cell loss contributes to corneal edema. this edema resulting in a loss of visual acuity and may require corneal transplantation as a last resort. various studies describe some factors that affecting endothelial cell loss such as the cataract density, pupil abnormalities (small diameter), advanced age or short axial length. however, few studies have been demonstrated the link between endothelial cell loss and the volume of fluid used during the intervention or the use of intracamerular substances. this study wants to establish a correlation between endothelial cell loss and predictive factors. thus, knowledge of these factors would have ensured a better control of endothelial dysfunction.

Eligibility criteria:
inclusion criteria: * patients undergoing cataract surgery * visual acuity monoyer scale \ +0.2 logmar) * nuclear, cortical and posterior subcapsular cataract with normal density to severe in the locsiii classification * covered by the social security scheme * have given their oral agreement exclusion criteria: * corneal disease: keratitis, dystrophy or corneal degeneration * any disease of the anterior segment * low preoperative endothelial cell density \<1000 c/mm² * pregnancy, lactation * risk factors for surgical per-operative complication * uncontrolled ocular pressure * combined surgery (cataract with corneal graft, cataract with glaucoma surgery, cataract with vitrectomy, ....) * under legal protection

Keywords: endothelial cell loss
measurement of perioperative glomerular filtration rate

Conditions: Rectal Cancer; Colon Cancer

Summary: our objective is to monitor glomerular filtration rate (gfr)during the perioperative phase of patients undergoing robotic surgery for rectum or large bowel cancers. we will use both a single injection and a continuous infusion of iohexol to measure kidney function for 72 hours after surgery.

the considerable morbidity and mortality associated with perioperative acute kidney injury (aki) is well documented and known to complicate recovery from surgery. accurate, direct measurements of glomerular filtration rate (gfr) may provide a tool to monitor perioperative onset of rapidly changing renal function. this may subsequently lead to design of randomized controlled trials examining the effects of earlier intervention with the aim to reduce the incidence of perioperative aki. recently a protocol for continuous infusion of low-dose iohexol (cildi) as a measure of gfr in stable patients over a range of gfr (28-128 ml/min/1.73 m2) has been developed. accuracy of this infusion protocol was confirmed with the single bolus injection (sbi) method. data also showed that the continuous infusion protocol of low-dose iohexol is an accurate and precise method when measuring changing gfr even in critical ill patients with variable aki risks. accordingly, sbi and cildi together now allow us to explore unanswered research questions related to perioperative change in renal function.

Eligibility criteria:
inclusion criteria: * rectum or colon cancer exclusion criteria: * acute kidney injury grade 3 or higher
impact of vitamin b12 replacement on epogen dosing and improvement of quality of life in hemodialysis patients

Conditions: Vitamin B12 Deficiency

Summary: vitamin b12 has several important functions in the body, two of which are production of red blood cells and the maintenance of a healthy nervous system. when vitamin b12 is deficient, abnormal red blood cells form. these cells are called megaloblasts. the end result is a decreased number of red blood cells; a condition called anemia. some symptoms of anemia include fatigue, weakness, shortness of breath, and pallor. vitamin b12 is also important in maintaining a healthy nervous system. nerves are surrounded by an insulating material that helps them conduct impulses. patients with low b12 levels who receive this vitamin in injection form, state that there quality of life is better. anemia in hemodialysis patients is treated with epogen, a synthetic material which helps your body make blood cells. the investigators believe that if you have a low vitamin b12 level in your blood and the investigators give you the vitamin during dialysis your requirement for epogen will be lower and you will be able to produce blood cells better. when evaluating for vitamin b12 deficiency a special test is needed called methylmalonic acid level (mma). this is a blood test that will be performed and when this level is high and your vitamin b12 level is in the low normal range the investigators can make a diagnosis of vitamin b12 deficiency.

background: vitamin b12 deficiency may have deleterious effects on end stage renal disease (esrd) patients on maintenance hemodialysis, and may increase erythropoietin stimulating agent (esa) resistance, yet little is known about its prevalence in this population. methods: serum vitamin b12 and methylmalonic acid (mma) levels were drawn from esrd patients prior to hemodialysis. all patients with mma levels greater than 800 nmol/l had peripheral smears evaluated for b12 deficiency. those with confirmatory smears were considered to be deficient and received intramuscular vitamin b12 injections for 4 months. post-treatment mma levels and smears were obtained. erythropoietin dosages were monitored throughout the treatment period.

Eligibility criteria:
inclusion criteria: * · patients on hemodialysis for at least 6 months * patients on stable dose of epogen and iron supplementation for at least 1 month prior to b12 and mma assay. exclusion criteria: * · on b12 treatment * hematological cancer * methotrexate use * alcohol use greater then 2 drinks per day * vegetarian diet * gastric surgery * inflammatory bowel disease * pernicious anemia * recent transfusion

Keywords: hemodialysis viatmin b12 deficiency epogen
therapeutic effect of repetitive transcranial magnetic stimulaton on tinnitus

Conditions: Patients With Subjective Tinnitus

Summary: the purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rtms) is effective in the treatment of tinnitus.


Eligibility criteria:
inclusion criteria: * subjective tinnitus * age 18 years and older exclusion criteria: * meniere, conductive hearing loss, objective tinnitus * history of seizure disorder or epilepsy * clinically relevant psychiatric comorbidity * previous symptomatic stroke * surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation
safety and feasibility of remote ischemic conditioning on prehypertension and early-stage hypertension

Conditions: Prehypertension; Remote Ischemic Conditioning; Early Stage Hypertension

Summary: nowadays, the incidence of stroke in china has reached 1.6‰, and this disease has become a primary cause of death in china. one of its major risk factors is hypertension. as shown in the researches, the risk of stroke grows remarkably when the blood pressure increases and there exists a log-linear relationship between them. systolic pressure and diastolic pressure relate to the risk of stroke independently. systolic pressure decreasing 10mmhg will reduce the stroke risk by 31% and a decrease of 1\~3mmhg will reduce the stroke risk by20\~30%. as to diastolic pressure, a 5mmhg decrease will reduce the stroke risk by 34% and a 10mmhg decrease will reduce the stroke risk by 56%.in addition, patients with isolated systolic hypertension (spb≥160mmhg, dpb≤90mmhg) or critical isolated systolic hypertension (spb=140\~159mmhg, dpb\< 90mmhg) will suffer a higher risk of stroke than people with normal blood pressure. the acc has already revised its hypertension managementguidelines of the standard of diagnosis for hypertension and the timing of starting medical treatment in hypertensive patients. because more and more researches shown that people with blood pressure between 120-139/80-89mmhg have higher risk of ascvsd compared to those with blood pressure lower than120/80mmhg; however, in china, the diagnostic criteria for hypertension has not been revised yet. therefore, we still have a blind spot in treating such patients who suffer from borderline systolic hypertension at 130\~140 mmhg of blood-pressure with or without ascvd or those with the first stage hypertension but refusing to take anti-hypertension drugs. what is more, most of them are middle-aged adults, once they have a stroke, it would lead to terrible and costly consequences to both their family and society. thus, it is necessary to explore new non-pharmacological methods to control blood pressure for reducing the risk of stroke


Eligibility criteria:
inclusion criteria: * systolic blood pressure between 160 and 125 mmhg or diastolic blood pressure between 80 and 100 mmhg * age≥18 * essential hypertension * patient did not take anti-hypertensive medicine regularly exclusion criteria: * patients with severe uncontrolled diabetes * contraindication for remote ischemic preconditioning * life expectancy less than 1 year * patients with atrial fibrillation or other kind of arrhythmia * unwilling to be followed up or poor compliance.

Keywords: hypertension remote ischemic conditioning
compatibility of c7 with ketogenic diet in patients diagnosed with g1d

Conditions: GLUT1DS1

Summary: to explore triheptanoin (c7 oil) compatibility with the ketogenic diet by evaluating eeg, and seizure rate, glycemia and ketosis in proven g1d patients receiving a ketogenic diet.

this is a single site, open label proof of principle exploratory trial to investigate the compatibility of c7 oil with the ketogenic diet in subjects diagnosed with g1d. the ketogenic diet will have been previously described by the patient's treating physician independently of this study and for clinical reasons. the ketogenic diet supplies over 50% of calories from fat, subjects, who are already tolerating over this much fat as part of their previously prescribed ketogenic diet, will replace 45% of their daily caloric intake with the triheptanoin for 24 hours, during a 48 hour inpatient stay. subjects will have a continuous eeg to monitor for any potential c7 related changes in seizure before, during, and after triheptanoin oil ingestion.

Eligibility criteria:
inclusion criteria: * diagnosis of glucose transporter type 1 deficiency (g1d), confirmed by clinical genotyping at a clia-certified laboratory. * stable on ketogenic diet at 2.5:1 to 4:1 ratio (i.e., no changes in ratio will have taken place for 2 months). the initiation of a ketogenic diet is previous to - and thus is not part of this study. * males and females 30 months to 35 years and 11 months old inclusive. exclusion criteria: * subjects with evidence of independent, unrelated metabolic and/or genetic disease. * subjects with a chronic gastrointestinal disorder, such as irritable bowel syndrome, crohn's disease, or colitis that could increase the subject's risk of developing diarrhea or stomach pain. * subjects with a bmi (body mass index) greater than or equal to 30. * subjects currently not on ketogenic diet. * women who are pregnant or breast feeding may not participate. women who plan to become pregnant during the course of the study, or who are unwilling to use birth control to prevent pregnancy (including abstinence) may not participate. females age 10 and over will be asked to provide a urine sample for a pregnancy test via dipstick. subjects will be asked to agree to abstinence or another form of birth control for the duration of the study. * allergy/sensitivity to c7 * previous use of triheptanoin less than 1 month prior to study initiation. * treatment with medium chain triglycerides in the last 24 hours. * subjects exhibiting signs of dementia, or diagnosed with any degenerative brain disorder (such as alzheimer's disease) that would confound assessment of cognitive changes, in the opinion of the investigator. * active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements. * inability or unwillingness of subject or legal guardian/representative to give written informed consent, or assent for children age 10-17, * addition of a new antiseizure drug in the previous 3 months.

Keywords: g1d, glucose, transporter