Kornimate/medical-research-clean huggingface dataset:
study of the neural basis of analogical reasoning

Conditions: Frontotemporal Dementia; Progressive Supranuclear Palsy; Healthy Subjects

Summary: frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. the aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.


Eligibility criteria:
inclusion criteria: healthy subjects: * subject affiliated to national health insurance * informed consent signed * normal neurological examination * subject aged at least 20 patients: * ftd or psp diagnostic criteria filled * patient affiliated to national health insurance * informed consent signed exclusion criteria: * severe psychiatric symptomatology and psychotropic drug use * unability to understand or perform the cognitive tasks.
facial lipoatrophy correction experience with sculptra ("faces" study)

Conditions: Facial Lipoatrophy

Summary: 5 year, open-label study to evaluate safety of sculptra on the signs of lipoatrophy of the face in at least 100 evaluable subjects with human immunodeficiency virus.


Eligibility criteria:
inclusion criteria: * subjects seropositive for human immunodeficiency virus; * in the investigator's judgment, a high probability of 5 year survival and compliance with the study visit schedule; * initiating sculptra treatments; * ability to comprehend and sign an informed consent document prior to study enrollment. * no waiver, prospective or retrospective, to deviate in any way from the inclusion/exclusion criteria for clinical study subjects, defined in the study protocol, can be granted to clinical investigators. exclusion criteria * any active skin inflammation or infection in or near the treatment area; * any hypersensitivity to the components of sculptra * previous treatment with sculptra or any other product for facial lipoatrophy; * pregnancy or breastfeeding or anticipating becoming pregnant during the study period; and * any other excluding factors that, according to the investigator's judgment, would preclude enrollment in the study. * no waiver, prospective or retrospective, to deviate in any way from the inclusion/exclusion criteria for clinical study subjects, defined in the study protocol, can be granted to clinical investigators.

Keywords: facial lipoatrophy hiv/aids
kisspeptin/gpr54 pathway and early puberty

Conditions: Puberty, Precocious

Summary: there was a worldwide early trend in girls'age for puberty onset. the timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. this study was designed to explored the association of polymorphisms in kiss1/gpr54 pathway genes and the risk of early puberty in chinese han girls.


Eligibility criteria:
inclusion criteria: - clinical diagnosis of central precocious puberty or early and fast puberty. exclusion criteria: * the participants who were not the first visit to the hospital and had been treated before. * the participants who were with endocrine disorders.

Keywords: snp kisspeptin gpr54
risk factors for stroke or systemic embolism in chinese patients with non-valvular atrial fibrillation registry

Conditions: Atrial Fibrillation; Stroke

Summary: this study is aimed to validate the existing stroke risk stratification model for patients with atrial fibrillation (af) (cha2ds2-vasc score, chads2 score, atria score, abc score, etc.) and establish a new stroke risk assessment model using a nationwide af -specific registry in china.

this study is a multicenter prospective disease-specific registry of patients with atrial fibrillation (af) that will analyze factors that are associated with stroke or systemic embolic events in patients with af in china. approximately 5,000 prospective cohort of patients and 22,000 retrospective cohort of patients will be enrolled. consecutive patients who meet the eligibility criteria and provide informed consent. patients enrolled in the registry will be followed for approximately 3 years. patient follow-up by national center for cardiovascular diseases will continue as scheduled. atrial fibrillation data capture will include demographics, cardiovascular risk factors, diagnosis, type of af (paroxysmal, persistent, permanent af), treatment strategy (rate vs. rhythm), antithrombotic therapy, concomitant medications and doses, laboratory tests, echo and computed tomography results, blood sample, insurance and provider information, comorbidities, and outcomes. the primary outcome will be stroke or non-cns embolism. other pre-defined outcomes of interest will include major adverse cardiac events, all-cause mortality, cause-specific death (sudden, non-sudden, heart failure-related), major bleeding, and hospitalization for heart failure.

Eligibility criteria:
inclusion criteria: * 18 years of age or older; male or female. * history of documented atrial fibrillation. * able to provide written informed consent. exclusion criteria: * subjects with moderate or severe mitral stenosis or a mechanical heart valve * subjects with previous or planned af ablation. * subjects with previous or planned left atrial appendage closure. * subjects unable to cooperate with follow-up after assessment.

Keywords: stroke atrial fibrillation risk factors registry
remote ischemic preconditioning for renal protection in tavi

Conditions: Aortic Valve Stenosis; Renal Insufficiency; Contrast-induced Nephropathy

Summary: severe aortic stenosis remains a major cause of morbidity and mortality of the elderly affecting approximately 3% of elderly patients with an increasing number of patients undergoing transcatheter aortic valve interventions. as part of pre-procedural planning these patients undergo ct scans and receive contrast during the procedure. these patients often have baseline renal insufficiency and are high risk of contrast induced nephropathy despite pre-hydration techniques. the purpose of this study is to evaluate the efficacy of this simple and safe procedure in preventing renal injury in this particular population.


Eligibility criteria:
inclusion criteria: - adults aged 18 or older presenting with moderate to severe aortic stenosis for a trans-catheter aortic valve intervention exclusion criteria: * patients in cardiogenic shock defined as requiring circulatory or hemodynamic support with a device, vasopressors or inotropes * systemic hypotension (systolic blood pressure \< 90mmhg) * patients currently on hemodialysis * presence of an arteriovenous dialysis fistula or graft or lymphedema in either arm * patients enrolled in other active cardiovascular investigational studies * severe comorbidities with a life expectancy of less than 6 months * pregnant or lactating women * patients unable to provide consent * patients taking the medication glibenclamide for treatment of diabetes
evaluation of tms visual outcome

Conditions: Cataract Surgery Experience

Summary: the goal of this clinical trial is to learn if transcranial magnetic stimulation (tms) can improve the visual outcomes in patients after cataract surgery. the main question it aims to answer is: • does tms improve the visual outcome in patients after cataract surgery? researchers will compare tms to the sham-controlled treatment (exposure to recorded sounds of pulses without real magnetic stimulation) to see if tms works to improve the visual outcomes of patients after cataract surgery. participants will * undergo tms treatment or a sham-controlled treatment for consecutive 5 days. * visit the clinic once every 2 weeks for checkups and tests.


Eligibility criteria:
inclusion criteria: * post cataract surgery * best-corrected visual acuity less than 0.1logmar exclusion criteria: * diagnosed with cognitive impairment or mental disorders and unable to cooperate with treatment; * diagnosed with significant opacity of refractive media that affects observation of visual function; * history of epileptic seizures; * long term use of psychotropic drugs； * metal implants in the body.
are doctors familiar with the test characteristics of lung cancer screening?

Conditions: Information About the Knowledge on the Statistical Background of Lung Cancer Screening of Doctors

Summary: this study evaluates whether doctors are familiar with the statistical background of lung cancer screening.

background: screening with low-dose ct scan can prevent three deaths due to lung cancer among 1000 high-risk individuals. however, false-positive results and radiation exposure are relevant disadvantages deserving accurate consideration. candidates for screening can only make an autonomous decision if doctors inform them correctly about the pros and cons of the method. therefore, this study aims to evaluate, whether doctors understand the test characteristics of lung cancer screening. methods: in a randomized trial, 556 doctors (members of the austrian respiratory society) will be invited to answer questions regarding lung cancer screening based on online case vignettes. half of the participants will be randomized to the group 'with data' and will receive the correct solutions in advance. the group 'without data' will have to rely on prior knowledge or estimate. primary endpoint will be the between-groups difference in the estimated number of deaths preventable by screening. secondary endpoints will be the between-groups differences in prevalence of lung cancer, prevalence of suspicious results, sensitivity, specificity, positive-predictive value, and false negative rate. estimations will also be compared to actual values from the literature.

Eligibility criteria:
inclusion criteria: * doctors, who were in training or had a completed specialization training in: * pneumonology * internal medicine * surgery * or radiology exclusion criteria: * doctors, with a specialized training in * ent * pediatrics * pathology and doctors who had no e-mail address were excluded.

Keywords: lung cancer screening statistical background
efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children

Conditions: Gas Pain Related Intake

Summary: the aim of this study was to evaluate the efficacy and tolerability of α-galactosidase in pediatric patients with predominant gas-related symptoms.

most patients with functional gastrointestinal disorders complain of gas-related symptoms which can negatively affect quality of life, even in pediatric age. dietary and life-style changes, administration of simethicone, activated charcoal and probiotics may reduce intestinal gas but often results are unsatisfactory. literature shows that α-galactosidase is effective to reduce gas production and related symptoms in adults.

Eligibility criteria:
inclusion criteria: * pediatric out-patients with gas-related disturbances at least once per week over the last 12 weeks. exclusion criteria: * suspected episodes of hypersensitivity or allergy; * chronic organic disorders (by clinical history, physical examination, laboratory tests); * use of drug affecting the gi motility during the previous 4 weeks; * inability of the parent to comprehend the full nature and purpose of the study and unwillingness to co-operate with the investigator.

Keywords: irritable bowel syndrome (ibs) bloating abdominal distension flatulence α-galactosidase
japanese catheter ablation registry

Conditions: Catheter Ablation; Cardiac Arrhythmias

Summary: japanese cather ablation (j-ab) registry is a voluntary nationwide registry, performed by japanese heart rhythm society, collaborated with the national cerebral and cardiovascular center. the objectives of this registry are to observe and describe developments in the catheter ablation treatment of arrhythmia in japan and to provide reliable information on the type of activity performed and the facilities available in japanese arrhythmia units.

japanese cather ablation (j-ab) registry is a nationwide, multicenter, observational registry, performed by japanese heart rhythm society, collaborated with national cerebral and cardiovascular center. this study is a voluntary nationwide registry and data are collected prospectively using a research electronic data capture (redcap) system. detailed data collection including antiarrhythmic medication is also performed at every september. the acute success rate at discharge and the complications associated with ablation procedure will be collected in all cases. major bleeding events are defined according to bleeding academic research consortium criteria. based on the provided information, the annual incidence and predictive factors for outcome will be investigated by the event assessment committee.

Eligibility criteria:
inclusion criteria: * patients treated with catheter ablation in japan exclusion criteria: * patients who refused to consent

Keywords: catheter ablation cardiac arrhythmias registry complication redcap
indwelling interscalene nerve catheters in surgical management of idiopathic adhesive capsulitis

Conditions: Frozen Shoulder

Summary: in patients who undergo shoulder manipulation for idiopathic adhesive capsulitis, a postoperative indwelling analgesic pain catheter will improve patient outcomes by decreasing shoulder pain and improving range of motion compared to a single-dose interscalene block.

shoulder manipulation under anesthesia to treat idiopathic adhesive capsulitis is performed only when conservative treatment fails to remedy the condition. it is common practice to use an interscalene nerve block as anesthesia for this surgical intervention. this randomized prospective study is designed to evaluate the effects of two different anesthesia methods on patient's post-surgical rehabilitation after manipulation. forty patients scheduled for surgery will be entered into this study. patients will be randomly assigned to receive a single-doseinterscalene block or a single-dose interscalene block and an indwelling nerve catheter which will provide a continuous infusion of local anesthetic. patients with the continuous infusion of local anesthetic will receive the additional anesthesia for 24 hours. patient's range of motion will be evaluated pre-op, intra-op and post-operatively at 10 days, 4,8,16 weeks and 6 months

Eligibility criteria:
inclusion criteria: * males and females over the age of 18 with a diagnosis of idiopathic adhesive capsulitis * failed conservative treatment for a minimum of 4 months * patient had 3 sequential office visits with no clinical improvement exclusion criteria: * adhesive capsulitis following a surgical procedure and/or fracture
cancer communication within hispanic social networks

Conditions: Colorectal Carcinoma

Summary: this trial examines cancer communication within hispanic social networks. hispanics have the lowest colorectal cancer screening rate of any major ethnic group and health interventions are crucially needed among hispanics. patient decision aids are health communication interventions designed to provide patients with targeted health information and have shown to improve colorectal cancer screening rates among hispanics. the goal of this study is to investigate, in a sample of hispanics, how a colorectal cancer decision aid aimed at increasing individuals' colorectal cancer screening behavior has effects on their alters' intention to get screened for colorectal cancer.

outline: participants view an educational video on cancer and cancer screening options over 12 minutes. participants also complete a phone survey over 10-15 minutes before attending the video session and 2 months after the video session.

Eligibility criteria:
inclusion criteria: * self-identify as "hispanic" or "latino" * have no family history of crc * have no personal history of pre-cancerous (adenomatous) colonic polyps * have not had either an annual fecal occult blood test (fobt) within the past year or colonoscopy within the last 10 years (defined as up-to-date with crc screening by current united states \[u.s.\] preventive services task force recommendations) * have at least two family members, friends, or co-workers who are ages 50-75 * alters will be eligible if they are ages 50-75
vitamin d and genetics in nutritional rickets

Conditions: Nutritional Rickets

Summary: the purpose of this study is: 1. to compare the response of rickets to calcium with and without vitamin d. 2. to assess whether vitamin d increases calcium absorption in calcium deficiency rickets. 3. to compare the response of children with and without rickets to orally administered vitamin d3 and vitamin d2 4. to identify mutations that influence calcium and vitamin d metabolism among families of children with rickets in nigeria and bangladesh. 5. to assess the functional status of the 25-hydroxylase enzyme in families possessing a 25-hydroxylase mutation.

previous studies of nigerian children with rickets demonstrated the superiority of calcium over vitamin d in producing healing. it is not known whether the addition of vitamin d to calcium will produce a better response to treatment than calcium alone in nigerian children. a previous study suggested the possibility that vitamin d may augment the effect of calcium. we will compare the response of rickets to calcium with and without vitamin d. in addition, very little human data clearly demonstrates the effect of supplemental vitamin d on calcium absorption. we will assess whether oral vitamin d increases the already high calcium absorption even further. recent published data indicate that the increase in serum 25-hydroxyvitamin d may be more sustained with vitamin d3 than with vitamin d2. we will compare the response of nigerian children with and without rickets to orally administered vitamin d3 and vitamin d2. because nutritional rickets tends to run in families, we will also examine amplified dna for evidence of mutations that influence calcium and vitamin d metabolism among families of children with rickets in nigeria and bangladesh. families possessing a recently identified 25-hydroxylase mutation will be given oral vitamin d2 and vitamin d3 to determine the functional status of the 25-hydroxylase enzyme.

Eligibility criteria:
inclusion criteria: * clinical features of rickets * active rickets on x-ray exclusion criteria: * treatment with calcium or vitamin d in preceding 30 days

Keywords: rickets calcium vitamin d nutrition child
salutogenic frailty prevention program for women aged 55 years and over

Conditions: Frailty; Frailty Syndrome; Salutogenesis; Sense of Coherence

Summary: frailty is a condition of reduced the capacity in multiple body systems and causing adverse outcomes because of decreasing the ability to cope with stressors. female sex, the changes of the body imposed by ageing, and coping strategies for stressors are causal mechanisms in the development of frailty. this project is designed with the salutogenic model that is focused on the concepts of health, stress, and coping. the aim of this project is to assess the effect of salutogenic frailty prevention program on promoting sense of coherence and preventing the development of frailty in women aged 55 years and over


Eligibility criteria:
inclusion criteria: * willing to participate in the study * woman aged 55 years and over * pre-frail (total frail scale score 1 or 2) * has internet access exclusion criteria: * to be semi-dependent and dependent according to the katz daily activities activity scale * to have any cognitive, psychiatric and neurological disorders * to have any surgical operation in the past 3 month * communication barrier (due to hearing/vision impairment)
picco assessment in patients with septic shock

Conditions: Septic Shock

Summary: sepsis is the result of a complex pathological process which involves an intravascular inflammatory state, loss of vascular tone, endothelial injury, extravascular leakage, and often inefficient myocardial contractility. these affect the cardiovascular homeostasis as well as the regional perfusion and tissue oxygenation of patient. the importance of early cardiovascular support in septic patients is the reason why, for about fifteen years, the implementation of standardized resuscitation protocols has been emphasized. the surviving sepsis campaign guidelines (ssg) recommend an initial fluid resuscitation followed by use of a vasoactive agent such as norepinephrine for the treatment of patients with septic shock. to understand the impact of the hemodynamic support provided by the resuscitation strategy, the assessment of surrogate clinical parameters is pivotal. according to the current guidelines, the increase of mean arterial pressure (map) above 65 mmhg represents the threshold in defining patients as "stable". although this strategy has been well established, its impact on the actual hemodynamic profile of the septic patient, remains a subject of ongoing controversy. in this scenario, the transpulmonary thermodilution technique (tptd) allows invasive assessment of the patient hemodynamic profile in terms of fluid responsiveness, vasomotor status, or global cardiac efficiency. by using this technique, several studies highlighted a wide variability in the individual response of patients undergoing cardiovascular stabilization guided by ssg. this suggests that the implementation of a "customized" resuscitation protocol based tptd derived parameters rather than resuscitation strategy guided by a fixed mathematic model, could be preferred. however, in daily clinical practice, the use of this advanced hemodynamic monitoring system in not routinely used, though it is often reserved in case of failure of the initial ssg-resuscitation protocol. the investigators supposed that, even if the initial resuscitative efforts were successful in achieving the ssg targets i.e. by restoring the map \> 65 mmhg, this could still be inadequate in some patients. accordingly, the investigators hereby will report the hemodynamic profile of patients with septic shock admitted in icu.


Eligibility criteria:
inclusion criteria: * older than 18 years * admitted in icu with diagnosis of septic shock exclusion criteria: * contraindication at the insertion of the picco catheter; conditions able to bias the transpulmonary thermodilution technique results (atrial fibrillation, extracorporeal membrane oxygenation, valvular disease and/or cardiomyopathy * pre-existing respiratory and cardiovascular pathologies * pre-existing kidney pathologies