Kornimate/medical-research-clean huggingface dataset:
effect of mindfulness-based stress reduction on birth memory and perception of traumatic birth

Conditions: Postpartum Psychological Stress; Mindfulness-Based Stress Reduction; Maternal Health; Traumatic Birth

Summary: this randomized controlled trial aims to evaluate the effects of a mindfulness-based stress reduction (mbsr) program on birth memory and perception of traumatic birth among women who have undergone vaginal delivery. the study will be conducted between july and october 2025 at malatya training and research hospital. participants in the intervention group will attend an 8-week mbsr program, while the control group will receive no intervention. data will be collected using validated scales before and after the intervention. the primary outcomes are changes in birth memory and traumatic birth perception scores.

this study is a pretest-posttest control group experimental design conducted to determine the effects of a mindfulness-based stress reduction (mbsr) program on birth memory and the perception of traumatic birth. the population of the study will consist of women who have had a vaginal delivery and received postpartum care at malatya training and research hospital between july and october 2025. the sample will include 80 women, with 40 in the experimental group and 40 in the control group. the intervention group will participate in an 8-week mbsr program, which includes weekly 60-90 minute sessions-first face-to-face and the rest conducted online. the program content will cover mindful breathing, body awareness, stress and emotion regulation, and interpersonal mindfulness. data will be collected using the mindfulness scale, the birth memory and recall scale, and the traumatic birth perception scale. pre-test data will be collected during the initial hospital visit, and post-test data will be collected at the end of the 8-week program. no intervention will be applied to the control group. statistical analyses will include descriptive statistics, independent samples t-tests, and paired samples t-tests. ethical approval has been applied for and informed consent will be obtained from all participants.

Eligibility criteria:
inclusion criteria: * women who have undergone a vaginal birth * literate and able to understand turkish * no diagnosed psychiatric disorder * have access to internet and a smart device (for online mbsr sessions) exclusion criteria: * history of pregnancy loss, stillbirth, or neonatal death * complications during postpartum period in mother or newborn * incomplete data collection or failure to attend mbsr sessions

Keywords: mindfulness postpartum stress maternal mental health midwifery
conservative versus surgical treatment of umbilical pilonidal disease

Conditions: Pilonidal Sinus; Sinus; Dermal, Pilonidal; Umbilical Granuloma

Summary: the aim of the study was to compare the results of conservative and surgical treatment, to create an algorithm for the management of the disease, and gain more information about the etiology, pathogenesis, and course of the disease. the investigators hypothesise that surgical treatment of ups will be better than conservative management in terms of recurrence rate, healing time, patient comfort and satisfaction, and cost effectiveness.

because of its rarity, umbilical pilonidal sinus (ups) is still poorly understood in terms of diagnosis, etiology, and the best treatment options. ups is thought caused by hair penetrating the skin, leading to a foreign-body reaction and development of a sinus lined with granulation tissue. most of the patients complain of pain, discharge or bleeding from the umbilicus when symptoms develop. it can be diagnosed with a careful examination, in which hairs can be seen deep in the umbilicus and usually protrude from a small sinus. regarding the optimal treatment of the disease, a complete consensus has not yet been achieved. some publications are recommended conservative treatment, while surgical treatment is recommended in others. a more meaningful comparison of the two modalities is that of a randomized controlled trial. we, therefore, present our data of prospective randomized controlled clinical trial comparing conservative versus surgical treatment of ups. this was a multicenter, prospective balanced randomization, double blind, active-controlled, parallel-group, superiority study conducted in turkey, under the direction of a principal investigator (mk). eligible patients with ups were randomized for either conservative treatment (ct) or surgical treatment (st), and then the results of both groups were compared.

Eligibility criteria:
inclusion criteria: * all patients willing to participate to the study with the diagnosis of umbilical pilonidal sinus exclusion criteria: * no informed consent * serious coagulation abnormalities * known allergy to local anesthetics * pregnancy, or women who refused contraception at the time of treatment * other concomitant umbilical pathologies such as umbilical hernia, granuloma, dermoid cyst * the patients who diagnosed with urachal and omphalomesenteric anomalies through radiological investigation * patients who underwent umbilical operation

Keywords: umbilical pilonidal sinus treatment surgery conservative investigational treatment after care
lactobacillus farciminis and hyperalgesia

Conditions: Inflammation; Pain

Summary: we want to analyse a possible effect of o dialy consumption of lactobacillus farciminis on a hyperalgesia on response to thermal stimulation. a comparaison of results before and after three weeks of treatment will be made.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * consumption of yogurts

Keywords: inflammation pain
phase 1 clinical trial to evaluate the safety, pk and pd of da-5207 tds in healthy adults

Conditions: Healthy

Summary: the purpose of this study is to evaluate the safety, pharmacokinetics and pharmacodynamics of da-5207 transdermal delivery system in healthy adults


Eligibility criteria:
inclusion criteria: * health voulunterrs (age : 19\~55 years) * body weight : male≥55kg, female≥50kg * 18.5 ≤bmi≤ 25.0 exclusion criteria: * galactose intolerance, lapp lactase deficiency, glucose-galactose malabsorption * allergy or drug hypersensitivity * clinically significant medical history * ast, alt \> upper normal range\*1.25, egfr\<60ml/min/1.73m² * heavy alcohol intake (more than 210g/week) * heavy smoker (more than 10 cigarettes/day) * heavy caffeine intake
intubation of patients with odontogenic abcesses

Conditions: Odontogenic Abscess

Summary: this study is a comparison of two techniques for endotracheal intubation (glidescope versus macintosh) in patients with odontogenic abscesses.

patients with odontogenic abcesses have to be treated by surgical drainage of the abscess under general intubation with endotracheal intubation. because of a limited mouth opening and swelling within the oral cavity, intubation can be difficult and sometimes impossible with conventional direct laryngoscopy. therefore, alternative techniques are desirable. we want to compare the success rate of intubation in these patients using the glidescope technique vs. conventional macintosh technique.

Eligibility criteria:
inclusion criteria: * patients have to have an abscess which has to be treated surgically. * mouth opening (inter-incisor gap) has to be less than 3.5 cm and more than 1.4 cm. exclusion criteria: * age under 18 years.

Keywords: intubation glidescope macintosh abscess difficult intubations in patients with odontogenic abscesses
prospective comparison of cold polypectomy and conventional polypectomy for small colorectal polyps in patients taking antithrombotic agents

Conditions: Colorectal Polyps

Summary: 1. background: the ideal method to remove small colorectal polyps in patients who are taking antithrombotic agents is unknown. 2. aim: the aim of this study is to evaluate postpolypectomy bleeding and the complete retrieval rate after the removal by colon snare transection without electrocautery for small polyps in patients who are taking antithrombotic agents. 3. design: a prospective, consecutive study. 4. setting: municipal hospital outpatients. 5. interventions: polypectomy by cold snare technique (cold polypectomy) was performed for colorectal polyps up to 10 mm in diameter in patients who continue to take antithrombotic agents. the primary outcome measure was bleeding within two weeks after polypectomy. secondary outcome measure was the complete retrieval rate of colorectal polyps based on the pathological examination.


Eligibility criteria:
inclusion criteria: * patients with colorectal polyps up to 10 mm in diameter. the patients continue to take antithrombotic agents. exclusion criteria: * patients are less than 20 years old, * pregnant, * american society of anesthesiologists class iii and iv, * overweight (body weight \> 100 kg), or * allergic to propofol used or its components (soybeans or eggs), * with previous colorectal surgical resection.

Keywords: 10 mm in diameter antithrombotic agents
a study to demonstrate the efficacy and safety of motilitone®

Conditions: Functional Dyspepsia

Summary: this is a phase iv , comparative study to evaluate the efficacy and safety of motiltone® in treatment of the patients with functional dyspepsia. the study is conducted with following methods: multi-centers, double blind, randomization, parallel. the subjects will receive motilitone® or/and pantoline®.


Eligibility criteria:
inclusion criteria: * roman iii criteria * one or more conditions are applied: epigastralgia, burning feelings in the solar plexus early satiety, uncomfortable fullness * no organic lesion exclusion criteria: * has been administered or was administered within a month * had a surgery that might affect gastrointestinal motility * tegaserod
evaluation of omentopexy on gastro-oesophageal reflux following sleeve gastrectomy

Conditions: Obesity

Summary: the aim of the study is to assess impact of omentopexy on de novo gastro-oesophageal reflux disease (gerd) after sleeve gastrectomy. this will be assess 2 years postoperatively. this study is a prospective, multicentric, randomized trial. five hundred twenty six patients should be included with 263 in each arm. first arm will include patients who have a sleeve gastrectomy. the second arm will include patients who have sleeve gastrectomy with omentopexy. two years after surgery , it will be collected a carlsson score and baros score (quality of life). the main objective is to show that omentopexy decreases the rate of de novo gerd after sleeve gastrectomy at 2 years postoperatively without the use of proton-pump inhibitors (ppis)


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old, * patient to be operated in first intention of a sleeve gastrectomy * initial bmi between 35kg/m² and 40 kg/m² associated with an obesity-related comorbidity (hypertension, obstructive sleep apnea syndrome, type ii diabetes, early osteoarthritis authenticated by a rheumatologist or an orthopedist, dyslipidemia, hepatic steatosis) or initial bmi ≥ 40 kg/m². * multidisciplinary follow-up of at least 6 months before surgery * validation of the surgical intervention in a multidisciplinary consultation meeting * certificate of no contraindication by a psychiatrist * patient who has the capacity to understand the protocol and has given consent to participate in the research, * patient with social security coverage. exclusion criteria: * eating disorder or mental disorder * misunderstanding of the protocol * psychiatric contraindication * initial bmi \<35kg/m². * initial bmi between 35kg/m² and 40 kg/m² without comorbidities. * esophagitis of grade b and above on the oeso-gastro-duodenal fibroscopy * carlsson score (score ≥ 4) preoperatively * presence of a proton-pump inhibitors treatment * patient to have a 2-stage surgery (first sleeve gastrectomy then gastric bypass or single anastomosis duodeno-ileal bypass) * patient participating in another interventional clinical research protocol involving a drug or medical device * patient who are pregnant, breastfeeding, or who have the potential to become pregnant without effective contraception at the time of inclusion and up to 24 months after surgery * patient under guardianship, curators or legal protection,p

Keywords: sleeve gastrectomy omentopexy gastro-oesophageal disease
safety and efficacy of cg53135-05 in the prevention of oral mucositis in patients receiving bone marrow transplant

Conditions: Stomatitis

Summary: cg53135-05, a recombinant human fibroblast growth factor-20 (rhfgf-20) protein, is under investigation for the prevention of oral mucositis. oral mucositis is a commonly occurring side effect of high-dose chemotherapy in patients undergoing autologous hematopoietic stem cell transplant. the objective of this phase ii trial is to evaluate the safety and efficacy of cg53135-05 when administered as a single dose to patients at risk for developing oral mucositis.


Eligibility criteria:
inclusion criteria: * male or female patients ages \> 18 yrs * patients undergoing high dose chemotherapy with or without radiation therapy treatment as conditioning for autologous hematopoietic stem cell transplantation. the conditioning regimens include at least one of the following: high dose melphalan (mel 200), busulfan, or etoposide, with or without total body irradiation. * patients with karnofsky performance scores \> or = 70% * informed consent for participation in study exclusion criteria: * patients who weigh \< 33 kg * premenopausal female patients who are pregnant, lactating or are likely to become pregnant * patients with active medical conditions that preclude autologous hematopoietic stem cell transplantation * patients diagnosed with active acquired immunodeficiency syndrome (aids) or hepatitis b/c * patients with known hypersensitivity to recombinant protein therapeutics * patients who have taken cg53135-05, palifermin or other investigational drugs in the past 30 days * patients who have untreated symptomatic dental infection * patients with a history of sensitivity or allergy to e. coli-derived products * patients with who grade 3 or 4 oral mucositis (om)

Keywords: oral mucositis oncology - supportive care mouth diseases
concomitant therapy of h. pylori

Conditions: Gastritis, Gastric Ulcer, and Duodenal Ulcer

Summary: if we compare eradication rate of helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(aoc), amoxicillin, rabeprazole, metronidazole(aom), treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days(sequential), amoxicillin, clarithromycin, metronidazole, rabeprazole(concomitant), then the eradication rate of concomitant group will be the highest.

* subject: the patient of gastritis, gastric ulcer, and duodenal ulcer infected with helicobacter pylori * 170 subjects per group * eradication regimens are as follows: aoc group, treated with amoxicillin, rabeprazole, clarithromycin for 7 days; aom group, treated with amoxicillin, rabeprazole, metronidazole for 7 days; sequential group, treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days; concomitant group, treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days

Eligibility criteria:
inclusion criteria: * patients infected with helicobacter pylori exclusion criteria: * cancer * pregnancy * formerly treated with eradication

Keywords: helicobacter eradication
the effect of mindfulness-based stress reduction program (mbsr) in risky pregnants

Conditions: Stress; Pregnancy, High Risk

Summary: risky pregnant women need various physical and mental health needs, they need to be informed and supported by health personnel. mindfulness is a non-judgmental and accepting focus of one's attention on what is happening right now. a total of 100 pregnant women (50 experimental, 50 control) are planned to be included in the study. data will be collected with "descriptive information form", "prenatal distress scale (pbl)-revised version", "pregnancy-related anxiety scale-revision 2" and "prenatal attachment inventory". in the study, a stress reduction program (mbsr) based on mindfulness will be applied by the researcher to the pregnant women in the experimental group.

risky pregnancies are a situation that can negatively affect the health of the mother and the fetus, result in the loss of the baby, and bring about physical, social and mental changes. mindfulness-based approaches have been used in solving both physical and mental problems in pregnant women and very positive results have been obtained. the aim of this study, which was carried out to determine the effect of mindfulness-based stress reduction program (mbsr) on stress, anxiety and prenatal attachment in high-risk pregnant women, is aimed at creating appropriate intervention programs for high-risk pregnancies and contributing to the improvement of pregnancy outcomes. a total of 100 pregnant women (50 experimental, 50 control) are planned to be included in the study. data will be collected with "descriptive information form", "prenatal distress scale (pbl)-revised version", "pregnancy-related anxiety scale-revision 2" and "prenatal attachment inventory". in the study, a stress reduction program (mbsr) based on mindfulness will be applied by the researcher to the pregnant women in the experimental group.

Eligibility criteria:
inclusion criteria: risky pregnant women exclusion criteria: mental disabilities

Keywords: prenatal attachment anxiety
feasibility and quality of teleconsultation in pediatric anesthesia

Conditions: Anesthesia

Summary: teleconsultation (tlc) being a new method of anesthesia consultation, deployed as an emergency in healthcare facilities in the covid context, it has never been evaluated either in terms of feasibility or in terms of quality. an initial assessment will highlight the pitfalls and difficulties encountered and suggest areas for improvement.

the evaluation of teleconsultation in pediatric anesthesia, a new consultation method developed in the context of covid for several weeks, appears necessary and will be a first inventory after its implementation in france. analysis of the data collected in this study will allow us to propose technical, medical and organizational solutions to optimize the positioning and practical use of tlc for patients and care facilities. this assessment step seems imperative if the covid context persists over time but could also be useful for the development of tlc outside the covid context.

Eligibility criteria:
inclusion criteria: * all patients under the age of 18 requiring an anesthesia consultation for an act requiring anesthesia * whose deprogramming in the context of the covid 19 pandemic would lead to a loss of opportunity for the patient, * or whose programming in the context of the covid 19 pandemic is in accordance with the recommendations made in field of the professional practice recommendations * and for which the family and the anesthetist have agreed to carry out the consultation by telemedicine exclusion criteria: * patient whose anesthesia consultation is performed face-to-face as a first-line decision * family refusing teleconsultation

Keywords: teleconsultation-anesthesia
comparing mobile health (mhealth) and clinic-based self-management interventions for serious mental illness

Conditions: Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Major Depressive Disorder

Summary: the study is a three year research project whose aims are to evaluate the willingness of individuals with serious mental illness to initiate the two illness self-management interventions- wrap or focus, to examine and compare participant engagement, satisfaction, and outcomes (symptoms, recovery, quality of life) in the two interventions.

the objective of the study is to compare two illness self-management interventions for smi: a clinic-based group protocol (wellness recovery action planning or wrap) and an mhealth smartphone intervention (focus). the study is structured as a randomized controlled trial, and data will be collected using a comprehensive mixed-methods quantitative /qualitative approach. this study will evaluate patients willingness to enroll in one of the two illness-self management interventions, patient satisfaction, engagement, symptoms, recovery and quality of life. the specific aims of the study are to: 1) evaluate and compare the willingness and ability of individuals with smi to enroll in the two illness self-management interventions; 2) examine and compare participant engagement and satisfaction with both treatments; and 3) examine and compare patient outcomes following participation in the interventions. participants will be randomized to receive 12-weeks of wrap or focus. participants allocated to the wrap group will be provided all other materials (i.e. wrap binder, handouts) in their first session and will meet weekly in groups with trained facilitators. participants in the focus group will be given a study smartphone device with focus application and trained by the mhealth support specialist on how to use the functions of the smartphone (i.e. using a touchscreen, call, text) and different features of the focus intervention.

Eligibility criteria:
inclusion criteria: * chart diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder; * 18 years or older; and * a rating of "3" or lower on one of the three items which comprise the domination by symptoms factor from the recovery assessment scale. exclusion criteria: * hearing, vision, or motor impairment that make it impossible to operate a smartphone (determined using demonstration smartphone for screening); * english reading level below 6th grade (determined using the wide range achievement test - 4th edition); and * received the focus or wrap intervention in the past 3 years.

Keywords: schizophrenia schizoaffective disorder bipolar disorder major depressive disorder mobile application smartphone smi illness self-management ehealth e-health health technology mhealth m-health
quality of life and psychological symptoms in children with cyclic vomiting syndrome (cvs)

Conditions: Vomiting Syndrome

Summary: the primary aim of this study is to characterize the quality of life of youth with cyclic vomiting syndrome (cvs) as well as the strategies they use to cope with stress, their strengths and vulnerabilities, and to assess symptoms of depression and anxiety in these at risk youth. the impact of cvs on the child's parent and family will also be assessed. a second aim is to evaluate the associations among coping strategies, personal strengths and vulnerabilities and the frequency and intensity of cvs attacks to determine if particular coping styles and personal characteristics are associated illness severity, psychiatric co-morbidity and quality of life


Eligibility criteria:
inclusion criteria: * diagnosis of cvs exclusion criteria: * children and parents who are not english speaking * youth with significant developmental delay, mental retardation, psychotic symptoms, or other significant mental impairments and those with other major medical disorders such as iddm, congenital heart disease, cystic fibrosis, etc.

Keywords: youth consensus criteria cvs
analgesic efficacy of ultrasound-guided transverse-abdominal plain blockade in urological surgery

Conditions: Postoperative Pain

Summary: the purpose of this study is to compare pain level (according to numerical score)at 4, 8, 12 and 24 postoperative hours between patients under transverse abdominal plain blockade (tap) and patients under conventional analgesia. also the opioid consumption is assessed.


Eligibility criteria:
inclusion criteria: * \> 18 yrs. * patients undergo laparoscopic urologic surgery * physical status asa \< 3 * surgical procedure without complications * signed informed consent exclusion criteria: * allergy to bupivacaine chlorhydrate * patients with chronic pain treatment * alcoholism * decompensated hepatic disease * coagulation disorders * bmi \> 35 * patient involved in another clinical trial

Keywords: postoperative pain transverse abdominal blockade efficacy safety urology