Kornimate/medical-research-clean huggingface dataset:
effect of bacillus coagulans and galactomannans on obese patients undergoing sleeve gastrectomy

Conditions: Obesity; Quality of Life

Summary: the purpose of the study is to determine the effect of bacillus coagulans and galactomannans (lactowise®) administration on obese patients undergoing sleeve gastrectomy by observing standard protocol measurements in patients following sleeve gastrectomy: laboratory measurements, ideal body weight, and percent estimated weight loss, in addition incorporating the gastrointestinal quality of life index (giqli)

loma linda university's school of allied health professions in collaboration with the metabolic and bariatric surgery department under the surgery division is conducting research to evaluate the influence of lactowise® (a proprietary blend of probiotic and prebiotic - bacillus coagulans/galactomannans, respectively) on the normal microbiota of obese patients post bariatric sleeve gastrectomy. pre-surgery, participants will be required to sign a consent form and to complete the gastro-intestinal quality of life index (giqli). a total of 60 bariatric sleeve patients will be recruited for this investigation. post-surgery participants will be randomized into two groups, one will receive lactowise® and one be the control (placebo). the lactowise® blend has 300 mg of the bacillus coagulans and galactomannans and contains around 4.5 billion live cells. daily intake of capsules coupled with bariatric sleeve standard of care will be conducted for the duration of 3 months, which is the anticipated clinical timeline. participants will also be asked to complete the quality of life questionnaire at each of the following follow-ups post-surgery: 2nd week, 6th week, and 3rd month. outcome measures will be the standard protocol for bariatric sleeve patients at the metabolic and bariatric surgery department which will include weight measurements, blood work. in addition to the standard of care procedures a research procedure to be added is the giqli. pre and post clinical consults, administration of probiotic/prebiotic formulae, and follow-ups will be conducted at the faculty medical offices - general surgery - bariatric clinic at loma linda university health.

Eligibility criteria:
inclusion criteria: * patient of bariatric sleeve surgery * ages 18-70 * consent to complete giqol questionnaire * commit to consistent use of lactowise® or placebo assigned for study period exclusion criteria: * none sleeve bariatric surgery patient * have compromised immunity or poorly controlled systems * presence of any concurrent active infection * physically disabled

Keywords: microbiota
quality of life and stigmatization in children with congenital melanocytic nevi before and after nevus excision

Conditions: Quality of Life; Stigmatization

Summary: congenital melanocytic nevi (cmn) are a quite common congenital disorder. over years, surgical excision was proposed to the patients because transformation into a malignant skin tumor (melanoma) was feared. recent data proof that the risk for malignancy was overestimated. nowadays still a lot of patients express their wish for surgical removal out of aesthetic reasons and psychological impacts. many patients and families experience stigmatization because of the nevus. to proof a medical indication for surgical removal the investigators want to evaluate the quality of life and stigmatization before and after nevus surgery.

all children with cmn that will have their nevus removed in our surgical department will be asked to participate. the investigators will send a package of questionnaires to evaluate quality of life and stigmatization before nevus surgery. one year after surgical therapy is finished (sometimes more then one session is necessary), the scar will be clinically evaluated and also another questionnaire package will be sent to evaluate the same parameters again. all parameters are checked for the patients and the families as well. therefore self and proxy reports of the parents are asked. moreover, for the patients this is done with interviews in case they are older than 7 years.

Eligibility criteria:
inclusion criteria: * patients with a congenital melanocytic nevi of at least 2 cm2 that will be removed surgically * age between 9 months and 16 years exclusion criteria: * mental retardation of the child * insufficient knowledge of the german language of both parents * severe comorbidities * previous therapies done for the cmn (dermabrasion, surgery, laser)

Keywords: quality of life nevus or scar stigmatization scar
anti-psychotic drug prescribing patterns within specialist adult id services in england and wales

Conditions: Intellectual Disability

Summary: the overall aim of this observational study is to establish the anti-psychotic prescribing patterns across specialist intellectual disability (id) services in england and wales by collecting cross-sectional retrospective data at 7 annual time-points (1st july) from 2017 to 2023.

feasibility protocol objectives: 1. is it feasible to identify people with intellectual disabilities (pwid) who have been prescribed 2 or more anti-psychotic medications over 7 years retrospectively. 2. it is possible to obtain a complete data set for each patient identified and therefore be able to explore the prescribing patterns across the eight sites. 3. is it feasible to quantify anti-psychotic treatment (apt) prescribing in pwid as chlorpromazine equivalent dose values across different healthcare trusts in england and wales. main objectives: 4. to explore yearly and overall prescribing patterns among pwid (with or without mental-health reasons (psychiatric co-morbidities)) in receipt of ≥2 forms of anti-psychotic treatment (multiple) over time? 5. how has multiple anti-psychotic treatment prescribing changed between 2017 and 2023 using chlorpromazine equivalent dose values, in pwid with mental health and no mental health indications? 6. what has been the impact of the covid-19 pandemic (and corresponding lockdown restrictions in england and wales) on multiple anti-psychotic treatment prescribing among pwid? 7. can the nhs england statistical process control tool (spc) be utilised to track yearly anti-psychotic treatment prescribing among pwid receiving multiple forms of anti-psychotic treatment, and monitor variation between services (sites) and patient groups (e.g. psychiatric co-morbidities; challenging behaviour).

Eligibility criteria:
inclusion criteria: * patient had psychiatric review by specialist adult id services in the last year (e.g. for a patient to be included at 1st june 2017, data to be recorded from the most recent psychiatric review within the period between 1st january 2017 - 31st december 2017). * patient has a diagnosis of id * patient under the care of specialist adult id services * patient on \>2 anti-psychotic treatments (oral and im injectable (depots)) exclusion criteria: * patients treated with clozapine * under the age of 18 years

Keywords: intellectual disability learning disability anti-psychotic treatments over-prescribing psychotropic
preoperative immunonutrition in patients undergoing spine surgery

Conditions: Arthrosis; Spine

Summary: a malnutritional status is known to be associated with altered immune function, reduced function, and worsen outcomes after orthopedic surgery. medical and surgical complications are not uncommon in orthopedics and infection rates are potentially life-threatening complications, with the highest morbidity, mortality, and healthcare costs. most patients undergoing orthopedic surgery are elderly, malnourished, osteosarcopenic, sedentary, anemic, and suffer from low levels of vitamin d. a mono-nutrient supplement may be not sufficient for supporting the arthrodesis techniques, which are invasive open surgeries procedures with significant blood losses and the need of transfusions. in this therapeutic area, immuno-nutrition has been used in spine surgery, with the reduction of complications, revisions, and readmissions. in addition, prosthetic surgery outcomes have been observed to ameliorate by using this nutritional support. therefore, preoperative oral immuno-nutrition therapy may be applied in older adults undergoing spine surgery to improve patients' outcomes and reduce complications. this is a randomized, controlled, open-label, 2-arm non-parallel-group, single-center interventional study to assess the efficacy of an immuno-nutrition therapy vs. hospital standard of care in spine surgery to improve patients' outcomes. this is a single primary endpoint study. a total of 136 patients from irccs orthopedic institute galeazzi in italy will be recruited and assigned in a 1:1 ratio to the treatment arm.


Eligibility criteria:
inclusion criteria: * male and female sex, of all ethnicities, aged over 60 * arthrodesis involving ≥ 6 vertebrae * american society of anesthesiology (asa) risk: 1, 2, or 3 * absence of neurological or psychiatric disorders * signing of informed consent and consent to collaborate in all study procedures * patients who meet the clinical requirements to undergo their first spinal surgery exclusion criteria: * american society of anesthesiology (asa) risk: 4 * no cervical arthrodesis * diagnosis of neurological or psychiatric disorders * revisions * therapy with other supplements at the time of the first visit 0 * known allergy or adverse food reactions * chronic inflammatory or autoimmune diseases (e.g. rheumatoid arthritis) * gastrointestinal disorders * conditions that do not allow to undergo surgery
measurement of spinal kinematics during various movements

Conditions: Low Back Pain

Summary: participants will perform movements while receiving different visual cues. spinal kinematics will be measured during these movements and compared between asymptomatic and clbp participants. participants will come for a unique session.


Eligibility criteria:
inclusion criteria: - sufficient french level to understand the instructions for the tests, the information sheet, the consent form. for clbp patients: - diagnosis of non-specific low back pain (pain from lower ribs to gluteal folds) for more than 3 months. for asymptomatic participants: * no history of lbp requiring medical attention during the last two years * no other concomitant pain or condition that could compromise the evaluation of lumbar kinematics. exclusion criteria: * pregnancy * skin allergy to tape * body mass index (bmi) above 32 for patients with clbp only: * specific low back pain (such as the presence of infection, rheumatological or neurological diseases, spinal fractures, tumours) * any known important spinal deformities * previous back surgery that limits spinal mobility * high level of pain at the time of experiment that prevents repeated movements (severity and irritability) * other concomitant pain or condition that could compromise the evaluation of spinal kinematics.
enhancing skin appearance and quality of life in breast cancer survivors on aromatase inhibitor therapy

Conditions: Anatomic Stage 0 Breast Cancer AJCC v8; Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Breast Adenocarcinoma; Estrogen Receptor-Positive Breast Carcinoma; Progesterone Receptor-Positive Breast Carcinoma

Summary: this study evaluates changes in skin quality and self-esteem among breast cancer patients who are initiating aromatase inhibitor therapy.

primary objectives: i. evaluate the incidence and severity of skin quality changes after initiation of aromatase inhibitor (ai) therapy in breast cancer (bc) survivors through use of canfield sciences visia-ca technology and facial skin assessment photography. ii. evaluate impact of ai therapy on patient-reported self-esteem and dermatology related life quality through validated patient reported outcome measures. iii. assess for objective improvements in skin quality measurements with visia-ca after skincare intervention with aesthetician consultation. iv. measure changes in patient-reported self-esteem and dermatology related life quality following skincare intervention. outline: this is an observational study. patients complete surveys/questionnaires, undergo skin measurement with the visia ca device, undergo facial skin photography, and attend consultations with an aesthetician on study.

Eligibility criteria:
inclusion criteria: * \* female ≥ 18 years * postmenopausal women suitable to receive aromatase inhibitor as per physician's discretion * histologically confirmed adenocarcinoma of the breast stage 0-iii with estrogen receptor (er) and/or progesterone receptor (pr) positive per american society of clinical oncology (asco)/ college of american pathologists (cap) guideline and any human epidermal growth factor receptor 2 (her2) * patients must not have received any prior chemotherapy or endocrine therapy for their current breast cancer. patients who received tamoxifen or raloxifene or another agent for prevention of breast cancer may be included * patients willing to avoid any facial procedures including facials, neurotoxin injections, fillers, or lasers during study period * willing and able to provide consent exclusion criteria: * \* patients who have previously taken ais * patients using prescription tretinoin, neurotoxin injections, fillers, facial lasers, microneedling, or facials within 6 months of study consent
investigation of the prevalence of sepsis in adults in multicenter intensive care unıts in turkey

Conditions: Sepsis

Summary: the pathophysiology and treatment of sepsis disease are still not fully known. international guides often refer to the studies done in the developed countries and suggest some treatments. the infrastructure of the developing countries is quite different. for this reason, it is not exactly scientific how much these proposals are reflected in patient treatment. in our study, we will try to reveal the treatment of sepsis.

sepsis is a clinical syndrome that has physiologic, biologic, and biochemical abnormalities caused by a dysregulated inflammatory response to infection. sepsis and the inflammatory response that ensues can lead to multiple organ dysfunction syndrome and death. in the late 1970s, it was estimated that 164,000 cases of sepsis occurred in the united states (us) each year. since then, rates of sepsis in the us and elsewhere have dramatically increased as supported by the following studies, although many of these are derived from academic institutions. the increased rate of sepsis is thought to be a consequence of advancing age, immunosuppression, and multidrug-resistant infection. it is also likely to be due to the increased detection of early sepsis from aggressive sepsis education and awareness campaigns, although this hypothesis is unproven. guidelines should focus on pre-hospital assessment and triage. indeed, respiratory infections represented the most common cause of sepsis in that cohort, and postoperative infections were another important part of the problem. whether these conditions apply to patients with shock in low-income and middle-income countries (lmic) is unknown, but the incidence of community-acquired infections would be higher, with a greater prevalence of gastroenteritis, septic abortion, and skin and soft tissue infections as causes of septic shock. the bacteriology of bloodstream infections across lmics varies substantially depending on regional and population characteristics. in a meta-analysis of 19 prospective studies on community-acquired bacteraemia in africa, the most common organisms isolated were salmonella spp (predominantly non-typhi), streptococcus pneumoniae, and gram-negative organisms such as escherichia coli.11 among cases for which mortality data were recorded, patients with bloodstream infections had an average mortality of 21.5%. although data are lacking, appropriate antibiotic treatment for these infections on the basis of bacterial resistance patterns will ultimately depend on the ecological pressures resulting from local antibiotic availability and patterns of use. we aimed to evaluate the approach to sepsis in turkey as a multi-centered study.

Eligibility criteria:
inclusion criteria: * 18 year old over exclusion criteria: * non-life expectant those who live longer than 24 hours not that consent
examining the impact of family connectors

Conditions: Caregiver Stress Syndrome

Summary: the purpose of this study is to understand the impact of family connectors, a peer-to-peer support and education program for family members who have participated in ontrackny, a treatment program for adolescents and young adults.

the study objectives are to examine the association between involvement in family connectors, a manualized peer-to-peer support and education program for family members of adolescents or young adults with symptoms of first episode psychosis, and feelings of empowerment, self-efficacy and social support.

Eligibility criteria:
inclusion criteria: * english speaking, due to the study materials not being validated in other languages. * 18 years of age or older, * family member of adolescents/young adults with first episode psychosis who participated in ontrackny. exclusion criteria: * does not provide informed consent.
quality-of-life impact of newly formed digitalized printed paper inserted into eyeglasses

Conditions: Orbital Deformity

Summary: a straightforward, user-friendly removable orbital prosthesis is a practical choice for effective rehabilitation in such patients with defective eyes. one of the essential elements for a good recovery is the retention of the prosthesis. the prosthesis can be retained by using a spectacle frame, conformers, adhesives, osseointegrated implants, magnets, or buttons. only osseointegrated prostheses in the maxillofacial region can use semi-precision attachments.

aim: using of eyeglasses with newly formed digitalized printed paper of mirrored photograph of an intact eye for orbital defected patients to restore the esthetic appearance. an evaluation of the quality of life for patients using temporalized eyeglasses with digitalized printed paper of mirrored photographs of a healthy eye.

Eligibility criteria:
inclusion criteria: * patients with an orbital defective eye (type i). * patients age more than 6 years. * patients with a unilateral enucleated eye. * skin-grafted orbital defects with a lack of natural retentive means either natural undercuts or retaining implants. * patients who are not prone to be received any prosthetic rehabilitation either for financial, age, or transportation problems of material that are needed for fabrication of prosthetic eye. exclusion criteria: * patients with the bilateral enucleated eye. * patients with primary signs of skin inflammation, infection, or untreated local disease * patients refusing to wear any eyeglasses. * patients with ocular defects.
discriminant capacity and thresholds of salivary cortisol in chemiluminescence in the diagnosis of hypercorticisms

Conditions: Cushing Disease

Summary: automated immunodosage methods (roche elecsys cortisol and ids cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory. they can be used to define robust diagnostic thresholds for salivary cortisol for the diagnosis of cushing's syndrome and pseudo-cushing combining the three tests performed as part of the patient's usual management. (ie two urinary free cortisol (ufc), the dexamethasone suppression test, and diurnal variation of plasma cortisol).


Eligibility criteria:
inclusion criteria: * the patient is under consultation in the department of metabolic and endocrine disorders at the chu nimes for diagnosis or follow-up of hypercortisol assessment * the patient must be a member or beneficiary of a health insurance plan exclusion criteria: * the patient is pregnant, parturient or breastfeeding * the patient has a cardiovascular or metabolic state against the indication of dexamethasone - patient with dfg \< 30 ml/min/1.73 m2 * the patient has suffered urinary incontinence rendering 24-hour urinary collection impossible or non-interpretable * the patient has a urinary catheter * the patient is taking corticoids (oral, inhaled, intra-venous or cutaneous) .patient exposed to interfering treatments (itraconazole, ritonavir, megestrol acetate, medroxyprogesterone acetate, tsh, estrogen-progestogen pill, hormonal coil) * the subject is in a period of exclusion determined by a previous study * the subject opposes their participation in the study * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship
study of alterations in tumor metabolism associated with the development of immunotherapy resistance in melanoma

Conditions: Melanoma (Skin)

Summary: among the mechanisms responsible for resistance to immunotherapy, metabolism seems to play a major role. a better understanding of tumor metabolism appears to be absolutely necessary in order to propose efficient therapeutic alternatives to target tumor cells without exerting a deleterious effect on the cells responsible for the anti-tumor immune response. the main objective is to evaluate metabolism modulations in melanoma cells extracted from metastases of patients sensitive and resistant to immunotherapies (anti-pd1 or anti-pd1+anti-ctla4).


Eligibility criteria:
inclusion criteria: * female or male, 18 years of age or older * stage iii unresectable or histologically confirmed stage iv cutaneous melanoma (melanoma of unknown origin is accepted), treatment naïve (metastatic stage) and for which immunotherapy will be started * performance status ≤1 * braf status available; braf status determination is required but patient will be eligible regardless of braf status * for women of childbearing potential, effective contraception must be initiated during the study. * patient affiliated to social security plan * patient having signed informed consent exclusion criteria: * breastfeeding or pregnant patients: for women of childbearing age, a urine pregnancy test will be performed * patients with ocular or mucosal melanoma of metastatic ocular melanoma * patients with metastatic melanoma not treated with immunotherapy (i.e. treated with a combination of targeted therapies). * contraindication to the initiation of immunotherapy: hiv and/or hcv and/or hbv positive, active autoimmune disease (chronic inflammatory bowel disease such as ulcerative colitis, crohn's disease, vasculitis, etc.), patients with autoimmune motor neuropathy (such as guillain barré syndrome). * vulnerable patients: minors, adults under guardianship or curatorship, deprived of liberty * vulnerable persons (minors, patients under guardianship or curatorship, deprived of liberty, under court protection, etc.). * a psychiatric or addiction history that will compromise the patient's ability to consent and follow the proper protocol procedures * any other clinical finding that, in the opinion of the principal investigator, could interfere with the results of the study or pose a risk to the patient during the study.
impact of measures taken to contain covid-19 on hospital surgical care services and clinical outcomes

Conditions: Surgery

Summary: this study aims to look at the impact on patient outcomes arising from measures implemented during the covid-19 pandemic. the information and knowledge from this study will be useful for the management and allocation of hospital resources and patients in tne event of a disease outbreak.


Eligibility criteria:
inclusion criteria: * this study involves the extraction of patient records from the enterprise dataware house. as such, we do not stipulate the age limits. * patients who had the following surgeries during over the period of 1 jan 2017 to 31 december 2020 * from the identified surgical procedure type or the following cancer-related procedures: 1. breast 2. colon 3. liver 4. rectum * selected non-cancer surgeries: 1. abdominal wall 2. gallbladder * patients from sgh and its related institute ncc * only local singapore citizens exclusion criteria: * no exclusion criteria

Keywords: covid-19 pandemic emergency cancer elective surgery postponement