Kornimate/medical-research-clean huggingface dataset:
physiotherapeutic scoliosis specific exercises as treatment for adult degenerative scoliosis

Conditions: Degenerative Scoliosis

Summary: this is a pilot study to lead to a larger prospective, randomized, controlled study of older adult (ages 50 and older) spinal patients with thoracolumbar/lumbar scoliosis evaluating improvement with physiotherapeutic scoliosis-specific exercise (psse) compared to traditional low back physical therapy (pt).

adult scoliosis with chronic back pain is a very complex condition. chronic back pain remains one of our country's most costly conditions to manage and treat. many of these patients have difficulty with activities of daily living (adl), household and community ambulation, and maintaining their professional career. the intervention options for this population remain limited, with surgery being the only one that has shown improvements in health related quality of life and an overall decrease in the complaints of pain. however, the costs of surgery and additional complications are limitations to this treatment option.there has been increased attention and interest in the medical community looking at the effects of physiotherapeutic scoliosis specific exercises (psse) on curve progression, improvements in health related quality of life, and pain. the investigators hypothesize that psse can directly affect radiological parameters, such as the sagittal vertical axis (sva), as well as showing improvements in health related quality of life using subjective patient specific outcome measures.

Eligibility criteria:
inclusion criteria: * 50+ years old * diagnosis of adolescent idiopathic scoliosis or adult idiopathic scoliosis; either with a cobb angle ranging from 20-100 degrees * complaint of back pain that has lasted longer than 6 weeks exclusion criteria: * any patient who has completed psse in the past * previous spinal surgery, trauma, or presence of neoplasms * diagnosis of congenital or neuromuscular scoliosis * subjects who are involved in concurrent interventions other than conventional physical therapy (pt)

Keywords: scoliosis psse
changes in fmri and neurocognitive function in women with pre-eclampsia

Conditions: Pre-Eclampsia; Neurocognitive Dysfunction

Summary: this is a pilot study assessing fmri changes and neurocognitive function in women with pre-eclampsia and healthy controls. neurocognitive testing will be done during pregnancy and after delivery up to 2-6 weeks postpartum. fmri will be done after delivery up to 2-6 weeks postpartum. the aims of this pilot study are therefore to 1) determine the frequency and nature of co-morbid dti white matter patency and fmri functional connectivity changes in women with pre-eclampsia/eclampsia and 2) determine the relationship between dti white matter patency and fmri functional connectivity changes to measurable alterations in cognitive function in this patient population. the aims of this pilot study are therefore to 1) determine the frequency and nature of co-morbid dti white matter patency and fmri functional connectivity changes in women with pre-eclampsia/eclampsia and 2) determine the relationship between dti white matter patency and fmri functional connectivity changes to measurable alterations in cognitive function in this patient population.


Eligibility criteria:
inclusion criteria:severe pre-eclampsia defined by * symptoms of central nervous system dysfunction (new onset cerebral or visual disturbance, such as: photopsia, scotomata, cortical blindness, retinal vasospasm) * severe headache (ie, incapacitating, "the worst headache i've ever had") or headache that persists and progresses despite analgesic therapy * altered mental status * hepatic abnormality (severe persistent right upper quadrant or epigastric pain unresponsive to medication and not accounted for by an alternative diagnosis or serum transaminase concentration ≥ twice normal, or both) * severe blood pressure elevation (systolic blood pressure ≥160 mmhg or diastolic blood pressure ≥110 mmhg on two occasions at least four hours apart while the patient is on bedrest (unless the patient is on antihypertensive therapy)) * thrombocytopenia (\<100,000 platelets/microl) * renal abnormality (progressive renal insufficiency (serum creatinine \>1.1 mg/dl or doubling of serum creatinine concentration in the absence of other renal disease)) * pulmonary edema 15 english-speaking pregnant controls with uncomplicated pregnancy matched by age and gestational age will be enrolled from the antenatal clinic or the labor ward. exclusion criteria: * history of symptomatic cerebrovascular disease with substantial residual deficit * history of alcoholism * history of psychiatric illness * history of claustrophobia * renal failure (creatinine \> 2.0 mg/dl) * patients with less than a 7th grade education or unable to read and thus unable complete the neuropsychological testing * patients with bodily implants unsafe for mri use

Keywords: pre-eclampsia functional magnetic resonance imaging neurocognitive function
variation of echocardiographic parameters after red blood cell transfusion in emergency department anemic patients

Conditions: Anemia; Age Problem; Ultrasonography

Summary: the goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. the main questions it aims to answer are : * is there a modification of echocardiographic parameters after red blood cell transfusion ? * which parameter is the most impacted by red blood cell transfusion ? participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.


Eligibility criteria:
inclusion criteria: * patient needing red blood cell transfusion * consent * social protection exclusion criteria: * fluid filing over 500 ml of crystalloids * transfusion in the last hour
a study on the safety and anti-hiv activity of he2000 in hiv-infected patients on salvage therapy

Conditions: HIV Infections

Summary: the purpose of this study is to see if it is safe and effective to give he2000, an experimental anti-hiv drug, to hiv-infected patients on salvage therapy (emergency treatment used when a patient has not responded to standard therapy). he2000 is a hormone that is suspected to make it more difficult for hiv to live in cells.

he2000 is a synthetic steroid hormone that, when tested in the laboratory, had anti-viral activity against wild-type and drug-resistant variants of hiv. he2000 works through a natural biochemical mechanism in cells to make them less able to support viral infection. there are 4 treatment groups of increasing doses of he2000; each group consists of 2 parts (part a and b). part a is a single administration of he2000 injected intramuscularly, and part b is 5 consecutive daily intramuscular injections of he2000. patients receive the same dosage throughout parts a and b of the study. patients are asked to return to the clinic periodically for blood sample collection. patients may remain at the hospital overnight for pharmacokinetic evaluation. drug safety, tolerance, efficacy, and pharmacokinetics are measured. samples from treatment group 4 are analyzed for specific cell function.

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are at least 18 years old. * are hiv-positive. * have been on their current anti-hiv drug combination for at least 30 days prior to the screening visit. * are currently failing at least their second anti-hiv drug treatment. * are not responding to their current anti-hiv treatment, have failed at least 1 anti-hiv combination, and do not have many options for treatment (groups 3 and 4 only). * are willing to not make any changes in their anti-hiv treatment until at least day 50 during the study. * have a cd4 count of at least 100 cells/mm3 at study entry. * have a viral load (level of hiv in the body) between 5,000 and 250,000 copies/ml at study entry. * agree to use barrier methods of birth control (e.g., condoms) during the study. exclusion criteria patients will not be eligible for this study if they: * have hepatitis b or c. * have been treated for cancer within 4 weeks prior to study entry, or will need to be treated during the study. (patients with kaposi's sarcoma are eligible but must not have received any treatment within 4 weeks before study entry or require treatment during the study.) * have received certain medications including those affecting the immune system. * are pregnant or breast-feeding. * have an active, serious infection, including opportunistic (aids-defining) infection that requires treatment during the study or during the 2 weeks prior to study entry. * have a condition or are receiving therapy that would prevent them from completing the study.

Keywords: injections, intramuscular drug interactions salvage therapy anti-hiv agents
rae (realize, analyze, engage)

Conditions: Substance Use Disorders; Treatment Adherence and Compliance

Summary: the proposed study will evaluate the detection of digital biomarkers of stress, and drug craving in a population of individuals undergoing treatment for substance use disorder

rae integrates digital detection of high-risk stress and craving periods by utilizing a mobile phone application and integrated wearable sensor. these detections are paired with interventions (mindfulness based de-escalation tools), support, and monitoring (to identify trends and plan for future). the present study will deploy the technology in a multi-site randomized controlled trial to test the efficacy of the rae system in on clinical and psychosocial outcomes. subjects will be randomized to use the rae system (mobile app and wearable sensor) plus usual care vs usual care plus a fitness tracker only to measure differences retention in treatment, return to substance use, and overall psychosocial functioning. the ultimate goal is to develop a cost-effective, paradigm changing recovery tool that will improve substance use disorder treatment, and prevent related complications and deaths.

Eligibility criteria:
inclusion criteria: * 18 years or older * enrolled in an outpatient sud treatment program * enrolled in treatment for \< 90 days * fluent in english * have access to a smartphone with ios or android capabilities * capable of providing informed consent exclusion criteria: * pregnancy * prisoner status * significant limitation of range of motion of non-dominant arm (amputation or fracture)

Keywords: mhealth stress craving wearables technology digital diagnostics digital health
effect of tulsi (ocimum sanctum) on biochemical parameters in young overweight and obese subjects

Conditions: Obesity

Summary: this is a study to investigate the effect of tulsi (ocimum sanctum linn.) on metabolic and biochemical parameters in young overweight and obese subjects. thirty overweight/obese volunteers will be divided into two groups. the first group will receive no intervention. the second group will be supplemented with one capsule of tulsi orally every morning and evening in empty stomach for 60 days. the metabolic parameters and liver enzymes will be evaluated before and after the intervention.

this is a randomized, parallel group, open label pilot study to investigate the effect of tulsi (ocimum sanctum linn.) on metabolic and biochemical parameters in young overweight and obese subjects. thirty overweight/obese volunteers will be divided into two groups. the first group will receive no intervention. the second group will be supplemented with one capsule of tulsi orally every morning and evening in empty stomach for 60 days. the metabolic parameters and liver enzymes will be evaluated before and after the intervention.

Eligibility criteria:
inclusion criteria: * overweight/obese volunteers of both genders from age 17 to 30 years exclusion criteria: * addiction to tobacco and/or alcohol. * not on drugs like fluoroquinolones, anticonvulsants, antihypertensives, corticosteroids, hormonal contraceptives, hypolipidemic agents, anti psychotics, protease inhibitors and isotretinoin. * not suffering from liver disease, malabsorption, nephrotic syndrome, thyroid disorder, allergy or any other chronic disease.
prediction value of panx1 in infection post liver transplantation

Conditions: Infection

Summary: the purpose of this study is to determine prediction value of panx1 expression in infection post liver transplantation.


Eligibility criteria:
inclusion criteria: * patients underwent liver transplantation. exclusion criteria: * re-transplantation * multiorgan transplantation * living donors or split-liver donors liver transplantation

Keywords: panx1 infection liver transplantation
ancillary study of the ultrec project

Conditions: Deep Vein Thrombosis

Summary: the ultrec research project is designed to assess the safety of a negative strategy relying on colour doppler ultrasound (cdus) for excluding the diagnosis of a new thrombosis. the ultrec project does not take into account the validity of the cdus positive criteria used to confirm the diagnosis of deep vein thrombosis (dvt) recurrence. the risk of considering only the negative strategy is to ignore the possibility of having an improvement in sensitivity and negative predictive value at the expense of specificity and positive predictive value and therefore to increase the false positive rate leading to an overdiagnosis of recurrence and an overtreatment, and a potential bleeding risk. in the ultrec-ancillary study, the research will aim at assessing the validity of baseline cdus positive criteria for the diagnosis of dvt recurrence. as there is no diagnostic standard to which the results could be compared, it is suggested to validate these criteria based on the evolution of the thrombosis on cdus performed at d90±5. the hypothesis is that an unchanged appearance under anticoagulation would be in favor of sequelae and will invalidate the initial diagnosis (diagnostic failure)


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. known history of objectively documented deep vein thrombosis of the lower limb (with or without pulmonary embolism) 3. out-patients referred for clinically suspected acute recurrent ipsilateral dvt of the lower limb 4. patients covered by social security or an equivalent regimen 5. no objection to the use of the data 6. inclusion in the ultrec study exclusion criteria: 1. known current pregnancy 2. any condition, which may prevent from performing the colour doppler ultrasound test 3. delay from onset of symptoms to inclusion of more than 10 days 4. therapeutic anticoagulation for more than 48 hours in the two days prior to consent to ultrec study 5. presence of clinical symptoms or signs of pulmonary embolism 6. life expectancy less than 3 months 7. patient unable to adhere to ultrec protocol follow-up 8. participants under judicial protection or incapacity

Keywords: deep vein thrombosis recurrence colour doppler ultrasound diagnostic strategy outcome
rapid diagnosis of covid-19 by chemical analysis of exhaled air

Conditions: Covid19

Summary: since the start of 2020, the new sars-cov-2 coronavirus is causing a real global health crisis. in france, nasopharyngeal swabs are used to obtain the sample needed for respiratory infection screening. there are three major difficulties with this type of sampling: i) it is really unpleasant for the patient because the device has to be pushed into the nostril to reach the nasopharynx. it causes some patients to bleed or even feel uncomfortable. ii) it is not easily accepted by children. iii) it is dependent on the availability of swabs. faced with these difficulties linked to the initial sampling, new methods are being studied to enable a rapid and non-invasive diagnosis of covid-19 based on the instantaneous identification of metabolites or volatile organic compounds (vocs). due to their sensitivity and the wealth of information that can be provided, the most promising techniques are based on mass spectrometry coupled with a soft ionisation system. for example, on-line exhaled air analysis is capable of detecting a very large number of vocs. various tests on metabolites in the exhaled air have already been carried out without being totally conclusive because the existing instruments suffer from various limitations: i) poor repeatability/accuracy in the chemical characterisation of exhaled air ; ii) too high specificity (detection of only part of the emitted compounds); iii) too limited sensitivity; iv) and poor adaptation to be deployed in a clinic. in order to overcome these various limitations, we propose the use of a new generation of mass spectrometer: vocus ptr-tof. the vocus ptr-tof is a proton transfer mass spectrometer (ptr-ms) developed for the detection, in real time, of trace vocs in industrial environments, laboratories or directly in the environment. this new generation of instrument offers the following advantages: i) unequalled sensitivity : ii) a robust ionisation system not affected by environmental conditions (relative humidity...) ; iii) a high mass resolution allowing precise identification of compounds ; iv) a compact and durable architecture allowing deployment in a constrained environment such as hospital, airport... the sensitivity and speed of measurement allow the expiration process to be monitored in real time, bringing an additional dimension to the measurement and the chances of success.


Eligibility criteria:
inclusion criteria: * symptomatic and asymptomatic outpatient without hospitalisation criteria * no medical contraindications to nasopharyngeal swabbing (deviation of the nasal septum, epistaxis, anticoagulant treatment). * patient able to blow into the test device * patients or parents with parental authority who have been informed of the study and have not objected to participating in it exclusion criteria: * major subject under guardianship or curatorship or unable to consent to study. * subject under safeguard of justice * minor patient (age \< 6 years).

Keywords: covid19 diagnostic proton transfer mass spectrometer exhaled air rapid and non-invasive diagnosis
the effectiveness of a running-related injury prevention program in runners

Conditions: Running-related Injuries

Summary: running is effective in increasing levels of physical activity and promotes a number of beneficial health effects. however, running can lead to running- related injuries (rri). in theory, such injuries can be avoided with the implementation of prevention programs. but in practice, there is a paucity of prevention programs that are effective in reducing the risk of rris. in a previous study, the investigators developed an rri prevention program using the intervention mapping framework. the rri prevention program was named runin3. the present study will evaluate the effectiveness of the runin3 rri prevention program. objective: to investigate the effectiveness of an rri prevention program (i.e., runin3). there will be recruited 530 runners of the state of são paulo aged 18 years or older. after inclusion, participants will be randomly assigned and allocated in two groups: (1) intervention group, which will be the target of the implementation of the runin3 prevention program; and (2) control group, which will receive a minimal intervention (i.e., feedback based on surveillance).


Eligibility criteria:
* running experience of at least three months; * residents of the state of são paulo; * no running-related injury (rri) at baseline; * no history of rri in the past three months.
motile sperm organelle morphology examination (msome) influence on intracytoplasmic sperm injection (icsi) outcomes in infertile couples

Conditions: Pregnancy

Summary: a new technique based on the motile sperm organelle morphology examination (msome) at a magnification of at least ×6000 has been developed. the msome assesses the nucleus, for both shape and chromatin content, which is the most important sperm organelle in influencing intracytoplasmic sperm injection (icsi) outcomes.

sperm morphology has been described as one of the major determinants of male in vitro fertility. however, the standard morphology evaluation on random stained cells from the ejaculate is of limited value during icsi. current research is directed towards the dysmorphisms of the sperm head.a new technique based on the motile sperm organelle morphology examination (msome) at a magnification of at least ×6000 has been developed. the msome assesses the nucleus, for both shape and chromatin content, which is the most important sperm organelle in influencing icsi outcomes. the goals for this study are to identify whether there is a connection between morphologic sperm normalcy under high magnification and (i) semen analysis according to the new world health organization (who) reference values and (ii) icsi outcomes.

Eligibility criteria:
inclusion criteria: * couples undergoing icsi as result of male factor or tubal factor or unexplained infertility * women with regular menstrual cycles of 25-35 days * women with normal basal follicle stimulating hormone (fsh) and luteinizing hormone (lh) levels * women with body mass index (bmi) less than 30 kg/m2 * women with both ovaries and intact uterus exclusion criteria: * women with polycystic ovaries syndrome * women with endometriosis * women with gynaecological/medical disorders * couples with any sexually transmitted disease * women who had received any hormone therapy for less than 60 days preceding the study
comprehensive assessment of nutrition and dietary intervention in hypermobile ehlers danlos syndrome

Conditions: Hypermobile Ehlers-Danlos Syndrome; Irritable Bowel Syndrome; Functional Gastrointestinal Disorders

Summary: this study involves a comprehensive nutritional assessment of heds participants who have functional gastrointestinal disorders and dietary intervention to broaden their food choices and nutritional intake.

the impact of diet on symptoms in patients with hypermobile ehlers danlos syndrome (heds/hsd) is widely recognised yet poorly understood. the investigators aim is to assess existing dietary patterns and nutritional status in heds/hsd as well as pilot a personalised dietary strategy to optimise nutrition. participants recruited from eds uk and a tertiary neurogastroenterology clinic at the royal london hospital will undergo comprehensive nutritional assessment and blood tests. the investigators will then undertake a feasibility study of personalised dietary intervention in select cohort of patients.

Eligibility criteria:
inclusion criteria: * have completed phase i of the candi-heds study * diagnosis of heds / hsd according to physical examination and history taking * diagnosis of functional dyspepsia and / or irritable bowel syndrome according to rome iv criteria * able and willing to give informed consent * access to video conferencing and a smart phone device * able to travel to the wingate institute exclusion criteria: * dependent upon artificial feeding (parenteral and enteral) * structural gastrointestinal disease * any chronic health condition which already requires a restricted diet e.g. diabetes mellitus * functional vomiting disorder with associated weight loss * multiple type i hypersensitivity reactions to food groups (i.e. anaphylaxis, urticaria, respiratory symptoms or positive rast tests). * previous or current severe mental health disorder (e.g. severe depression with suicidal ideation) * previous or current eating disorder * positive screen for avoidant restrictive food intake disorder (arfid)

Keywords: nutrition diet