Kornimate/medical-research-clean huggingface dataset:
lesion network mapping navigated continuous theta-burst stimulation for motor recovery in acute ischemic stroke

Conditions: Stroke, Acute Ischemic

Summary: this is a multicenter, sham-controlled, double-blind, randomized clinical trial to evaluate the efficacy and safety of lesion network mapping navigated ctbs in improving motor function in patients with acute ischemic stroke at 3-14 days after onset.

the target population of this study was patients with acute ischemic stroke. lesion network mapping and navigation were used to select individual stimulation targets. enrolled patients were randomly assigned in a 1:1 ratio to the "ctbs group" or the "sham stimulation group" and received: ctbs group: based on the map, an 8-shaped coil was used to stimulate the motor function-related targets. the stimulation intensity was rmt80%, 600 pulses, 50hz, 40s per target, and the stimulation interval was more than 2 hours. the total course of treatment lasted 7 days. sham stimulation group: a sham stimulation coil was used to stimulate based on the map. the sound and duration were the same as the ctbs group, ensuring no effective stimulation. the total course of treatment lasted 7 days.

Eligibility criteria:
inclusion criteria: 1. age 18-80 years old. 2. acute ischemic stroke confirmed by ct or mri at 3-14 days after onset. 3. pre-stroke modified rankin scale (mrs) score≤1. 4. 4≤nihss score≤ 25, 1a≤1, nihss5a/5b/6a/6b≥2 at least. 5. moderate or severe motor dysfunction (fugl-meyer motor score \< 80). 6. written informed consent from patients or their legally authorized representatives. exclusion criteria: 1. tms contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc. 2. epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders; 3. midline displacement and brain parenchymal mass effect seen in head ct and other images; 4. head ct or mri showed bilateral acute cerebral infarction; 5. evidence of acute intracranial hemorrhage; 6. a history of congenital or acquired hemorrhagic disease, coagulation factor deficiency, or thrombocytopenia disease; 7. after blood pressure control, the systolic blood pressure was still ≥180 mmhg or the diastolic blood pressure was ≥110 mmhg; 8. patients during pregnancy or lactation and within 90 days of planned pregnancy; 9. patients with severe mental disorders or dementia who can not cooperate with informed consent and follow-up; 10. patients with malignancy or severe systemic disease and expected survival of less than 90 days; 11. participants in other clinical intervention studies within 30 days before randomization or who were participating in other clinical intervention studies. 12. patients with ataxia (nihss 7 ≥ 1) and aphasia (nihss 9 ≥ 2).

Keywords: continuous theta-burst stimulation acute ischemic stroke motor recovery lesion network mapping navigation
complete lymph node dissection vs watchful waiting in patients with malignant melanoma (thickness of 1,0mm+ and evidence of metastases in the sentinel node)

Conditions: Melanoma

Summary: sentinel lymph node biopsy (slnb) is considered as standard diagnostic procedure in melanoma patients carrying a reasonable risk for metastases. in numerous studies the prognostic role of micro metastases in the sentinel node (sn) was described. however, the prognostic value of a complete lymph node dissection in patients with a positive sn is still unclear. this study was planned to analyse the survival outcome of patients with a positive sn receiving complete lymphadenectomy versus watchful waiting.


Eligibility criteria:
inclusion criteria: * cutaneous melanoma with a tumour thickness of at least 1,00mm * positive sentinel node with micro metastases of max. 2mm in diameter exclusion criteria: * mucosal or ocular melanoma * cutaneous melanoma located in the head/neck region * evidence of satellite, in transit or local metastases / recurrences * macro metastases of the sn or micro metastases of \>2mm in diameter * additional immune-suppressive therapy * pregnant of lactating women

Keywords: sentinel lymph node biopsy lymph node excision
physiotherapy versus use of a new ankle trainer device after ankle fracture operation.

Conditions: Ankle Fracture - Lateral Malleolus; Post-Op Complication

Summary: the study will compare the functions outcomes between two different rehabilitation protocol after operated weber b ankle fractures

patients that are operated for weber b ankle fractures will after the surgery be randomized into two different post operative rehabilitation protocols. one group will receive conventional physiotherapy with stretching of the ankle with a non-elastic band, while the other group will use a new spring-loaded ankle trainer. the rehabilitation will continue for 3 weeks. patients will be evaluated with the olerud molander ankle score and visual analog scale for pain at 3, 6, 12 and 52 weeks follow-up. length of hospitalization and all adverse events will be registered. ankle range of motion will be registered at 6, 12 and 52 weeks

Eligibility criteria:
inclusion criteria: * weber b ankle fracture. exercise stable osteosynthesis. good compliance exclusion criteria: * previous trauma to the tibia or fibula. previous ankle or foot surgery. sympthomatic arthritis or generalized joint disease

Keywords: ankle fracture rehabilitation
measuring quality of decisions about treatment of depression

Conditions: Depression

Summary: the purpose of this randomized controlled trial is to examine the impact of a patient decision aid on the quality of decisions about managing symptoms of depression. in particular, we will examine whether the decision aid increases knowledge about depression/managing depression symptoms and concordance between goals and treatment choices.


Eligibility criteria:
inclusion criteria: * aged 18+ * in the last 12 months, talked to a health care provider about starting or stopping a treatment (prescription medicine for depression or counseling) exclusion criteria: * none

Keywords: depression depressive disorder decision making decision aids decision quality instrument
effect of dill in thyroiditis and nodular goiter patients

Conditions: Thyroid Nodule

Summary: the aim of the study was to investigate the functional and morphological effects of anethum graveolens l. in patients with thyroiditis and nodular goiter by evaluating hormone levels, anti-inflammatory markers and comparing thyroid nodule sizes measured by ultrasonography for 90 days. the effect of anethum graveolens l. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. aerial parts of anethum graveolens l. were dried and grinded to yield a fine powder. size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. placebo was prepared in the same manner using maltodextrin. patients were suggested to take 3 pills a day. blood samples were collected at the initial and the final day for thyroid stimulating hormone (tsh), free triiodothyronine (ft3), free thyroxine (ft4), anti-thyroid peroxidase (anti-tpo), anti-thyroglobulin (anti-tg) and c-reactive protein (crp) analysis. nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms. after 90 days in the study, the status of tsh, ft3, ft4, anti-tpo and crp levels were examined in the group with and without anethum graveolens l.. again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive anethum graveolens l. by ultrasonography.


Eligibility criteria:
inclusion criteria: * to have multi-nodular goiter, * to be a benign result in fine needle aspiration biopsy, * euthyroid must be sick, * must be sick over the age of 18, * to accept the research. exclusion criteria: * thyroid function tests non-euthyroid individuals, * to have a malignant result in thyroid biopsy, * not giving approval, * to be renal failure, * benign pregnant, * taking blood thinning drugs

Keywords: anethum graveolens l. thyroiditis nodular goiter
abdominal or transanal tme for rectal cancer therapy

Conditions: Survival; Postoperative Morbidity; Mortality; Recurrence

Summary: this study assessed whether transanal tme in patients with rectal cancer is superior to open, laparoscopic, and robotic tme (abdominal tme (abtme)) regarding oncological outcome, postoperative morbidity and 90-day mortality.

rectal cancer accounts for 3.8% of all new cancer diagnosis and for 3.4% of all cancer-related deaths in the world in 2020. regarding treatment of rectal cancer, it is essential to perform surgery along the anatomical and embryological planes. this technique called total mesorectal excision (tme) reduces the local recurrence rate and improves the survival. since the early 2000, tme has changed from open to laparoscopic approach due to better results in short-term outcome. nevertheless, oncological benefits are modest. in 2009 the first ever transanal tme (tatme) war performed. this novel technique combines abdominal with transanal dissection. because the distal part of the rectum is approached from below, a better visualization of the mesorectal plane resulting in higher rate of free crm and of complete tme specimen grade (quirke score) can be accomplished. however, tatme remains a hot topic in the current scientific literature. in norway and the netherlands a higher rate of anastomotic leakage as well as a higher rate of local recurrence (9.5%) with multifocal growth pattern were described.

Eligibility criteria:
inclusion criteria: * all patients receiving elective total mesorectal excision exclusion criteria: * diagnosis other than rectal cancer * partial mesorectal excision * discontinuity resection (no anastomosis) * incomplete staging * metastatic cancer * lack of follow-up * decline of a retrospective data analysis * age under 18 years

Keywords: tme rectal cancer transanal local recurrence
establishing a longitudinal cohort study of lung cancer using tissue and peripheral blood metabolomics.

Conditions: Lung Cancer; Lung; Lung Cancer (NSCLC); Metabolomics

Summary: this study will utilize tissue and peripheral blood samples for metabolomics analysis and establish a longitudinal metabolomics cohort at multiple critical treatment time points to comprehensively investigate the role of metabolomics in the diagnosis, prognosis, and therapeutic monitoring of lung cancer. by profiling metabolic alterations, this study aims to identify potential biomarkers for distinguishing benign and malignant lung nodules, predicting therapeutic efficacy, and assessing long-term prognosis. key time points include initial screening for lung nodules, postoperative evaluation to predict treatment outcomes, and therapeutic monitoring to assess efficacy after medication or other interventions. through these analyses, the study seeks to uncover underlying metabolic mechanisms and provide valuable insights into personalized lung cancer management.


Eligibility criteria:
inclusion criteria: 1. signing of the informed consent form; 2. male or female, aged 18-75 years; 3. patients with lung nodules confirmed by ct examination; 4. good preoperative pulmonary function cooperation and complete reporting; 5. preoperative chest single/dual phase ct scans without significant artefacts and with complete imaging; 6. the interval between preoperative pulmonary function and single/dual phase ct scans does not exceed one month. exclusion criteria: 1. poor preoperative pulmonary function cooperation or missing reports; 2. preoperative chest single/dual phase ct scans exhibit significant artefacts or image omission; 3. the interval between preoperative pulmonary function and single/dual phase ct scans exceeds one month; 4. complication with severe respiratory disorders (such as lung transplantation, pneumothorax, giant bullae, etc.); 5. coexisting with other severe functional impairments; 6. patients with obstructive lesions such as airway or esophageal stenosis; (8) medication use before pulmonary function testing that does not meet the cessation guidelines; (9) pulmonary function report quality graded d-f.
building resilience and attachment in vulnerable adolescents

Conditions: Suicidal Ideation

Summary: suicide is the second leading cause of mortality for canadian adolescents. mental health complaints are one of the leading reasons for an emergency department visit at the children's hospital of eastern ontario and 60% of adolescents report suicidal ideation. the goal of the present investigation is to test the efficacy of a brief group intervention for adolescents with passive suicidal ideation and their caregivers that will focus on coping, familial support, and emotional regulation. the investigators hypothesize that a brief group intervention, delivered in the weeks following presentation for crisis services, will reduce suicidal ideation and improve coping and familial support.


Eligibility criteria:
inclusion criteria: * mild to moderate suicidal ideation * recently presented for services in response to a psycho-social crisis (emergency department, mh urgent care) * one or two caregiver(s) committed to attending the majority of sessions exclusion criteria: * presence of a suicidal plan and/or recent gesture/attempt * psychosis * schizophrenia * dual diagnosis * developmental disability or delay * "behavioural problem" as primary concern * major substance abuse * currently receiving mental health services (once every two weeks or more frequently) * inability to commit to majority of sessions (minimum 4 of 6 sessions) * children's aid society involvement * inability of at least one caregiver to commit to attending the majority of sessions

Keywords: adolescent suicidal ideation emergency department crisis attachment coping
psychosocial outcomes in families of covid-19 icu patients

Conditions: Critical Illness; Family; Psychological Stress; Covid19

Summary: during the first part of the sras-cov2 pandemic, families were not allowed to visit the patients in icu. we know that families can develop "family-pics" after their relatives' icu stay. the aim of the study is to study the psychosocial outcomes of families of patients who were admitted in icu for covid-19 during the pandemic. the second objective was to search for any differences in outcomes whether families benefited from video-conferences with the medical team and their relatives or not during the icu stay.


Eligibility criteria:
inclusion criteria: * the referent family member of any patient admitted in icu for covid-19 during the first part of the pandemic exclusion criteria: * cognitive disorders * not french-speaking * refusal to participate
autonomic nerve stimulation using external auditory canal electrodes

Conditions: Cardiac Arrhythmia; Cardiovascular Diseases

Summary: * purpose of the study this study aimed to investigate electrocardiogram measurement and subthreshold low-level autonomic nerve stimulation using external auditory canal electrodes among healthy adult participants * study design prospective, single-center, interventional, single-arm design * study participants a total of 12 healthy adult participants without cardiovascular diseases will be recruited. * study methods 1. participant enrollment study participants will be recruited by advertisement posters announced at the lobby of the hospital 2. evaluation of electrocardiogram measurement from external auditory canal electrodes participants are required to attach specially designed external auditory canal electrodes to their both ears to record electrocardiogram. both electrocardiogram from the precordium and the ear would be simultaneously recorded and compared. 3. evaluation of low-level autonomic nerve stimulation using external auditory canal using the electrodes described above, arnold's nerve will be stimulated with low-level electric impulses using tens device. during and after the stimulation, heart rate variability will be measured to investigate the impact of nerve stimulation on autonomic function modulation on the heart.


Eligibility criteria:
inclusion criteria: * healthy adults without cardiovascular diseases * aged 20 years or more with informed consent exclusion criteria: * patients with autonomic disorder, cardiovascular drug prescriptions, cardiovascular diseases, diabetes, or with cardiac implantable electronic devices * patients with abnormalities at both external auditory canals and ears
comparative study between tadalafil versus tamsulosin as a medical expulsive therapy for lower ureteric stones

Conditions: Lower Ureteric Stones

Summary: the aim of the work is to compare the efficacy of tadalafil and tamsulosin as a medical expulsive therapy for lower ureteric stones

gradually increasing incidence rate of kidney stone is a significant concern of medical world. genetics and/or life style accelerate the kidney stone formation (urolithiasis). sometimes, it is stuck up in ureter especially distal ureter; hence called as lower ureteral stone (lus) and causes intense flank pain beside urinary obstruction. the ureter contains α adrenergic receptors along its entire length with the highest concentration in the distal ureter. there has been a steep rise in minimally invasive procedures but medical expulsive therapy (met) is still regarded as an established treatment option for the management of distal ureteric stones. stone location, size, number, ureteric spasm, mucosal oedema or inflammation, and ureteric anatomy are the factors affecting passage of ureteric stones. drugs that expel stones might act by relaxing ureteral smooth muscle through inhibition of calcium channel pumps or α-1 receptor blockade. tamsulosin is one of the most commonly used α-blockers. phosphodiesterase inhibitors (pdei) are a class of drugs that inhibit the breakdown of camp and cgmp, enhancing smooth muscle relaxation. therefore, pdei may be able to decrease ureteral spasm and facilitate stone passage. tadalafil is a selective pde5i and because of its smooth muscle relaxation property, tadalafil received the us food and drug administration approval for lower urinary tract symptoms with benign prostatic hyperplasia and erectile dysfunction. monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms had already been demonstrated . with demonstration of in vitro effects of phosphodiesterase-5 inhibitor (pde5i) as tadalafil on isolated human ureteral smooth muscle, interest in use of pde5i as met has increased.

Eligibility criteria:
inclusion criteria: * patients aged ≥18 years * patient have a distal ureteric stone of 5-9 mm in greatest dimension * patient diagnosed by ultrasonography of the kidney, ureter, and bladder , x-ray kub and noncontrast computed tomography scan. exclusion criteria: * pregnant or lactating mothers. * patients have uti. * patients have severe hydroureteronephrosis. * patients have multiple ureteric stones. * patients have solitary kidney. * patients have acute or chronic renal failure. * patients have previous therapies for the stone. * patients with history of open surgery/endoscopic interventions. * patients have ureteric strictures. * patients take concomitant treatment with calcium antagonists, β-blockers, corticosteroids or nitrates.
using the movement and electromyographical analyses to assess the muscle spasticity

Conditions: Stroke

Summary: this study intends to use an dynamometer and surface electromyography to objectively and quantitatively measure the corresponding force and electromyography signal generated when the hand joint receives stretching by doing circular motion, and further explore the differences and relationships of existing muscle spasm classification, kinetic and kinematic data, upper extremity performance, activity of daily life. in addition, to investigate the differences of kinetic and kinematic data between stroke patient and healthy participants during doing hand circular motion activity.

purpose 1 : to collect upper limb muscle activity parameters of healthy adults and stroke patients to establish a database of doing hand circular motion activity. purpose 2 : to test the reliability of this refined muscle testing by collecting the muscle activity during hand circular motion activity. purpose 3 : to compare the results of the emg signal strength with other evaluation methods such as the modified ashworth scale and dynamometer to understand the relationship between the emg signal and each evaluation results. purpose 4 : to compare the differences in electromyographic signals, muscle strength, and joint angle between healthy adults and stroke patients.

Eligibility criteria:
inclusion criteria: * 20 to 65 years old * with the clinical diagnosis of stroke * mini-mental state examination (mmse) score ≥ 25 points exclusion criteria: * pain, subluxation or related medical history of shoulder, elbow, and wrist joints within six months * surgery on shoulder, elbow or wrist * with muscle or nerve disorders or diseases that significantly affect the performance of the upper extremities

Keywords: spasticity modified ashworth scale (mas) electromyography kinetics impedance
late subclinical cardiovascular disease in testicular cancer survivors

Conditions: Testicular Cancer; Survivorship; ASCVD; Coronary Artery Disease; Lipid Disorder; Hypogonadism, Male; Cisplatin Adverse Reaction; Bone Marrow Transplant Complications

Summary: late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant

testicular cancer (tc) is diagnosed in young adult males between 18-39 years old. there are late (≥10 years after treatment) atherosclerotic cardiovascular disease (ascvd) events after cisplatin-based chemotherapy (cbct) treatment in testicular cancer survivors (tcs), along with heightened rates of hypertension, dyslipidemia, diabetes mellitus, and metabolic syndrome. early detection of ascvd to direct preventive measures in young tcs is an unmet need as these patients typically fall short of traditional 40-45-year age-cut offs for ascvd screening. ascvd risk will be evaluated in tcs ≥ 10 years after treatment in three groups: 1)tcs exposed to cbct, 2)tcs exposed to cbct and bone marrow transplant (bmt), and 3)tcs cured with surgical resection/surveillance. the focus will be on detecting subclinical atherosclerosis in tcs using blood lipid biomarkers and advanced cardiac ct imaging.

Eligibility criteria:
inclusion criteria * patients \>18 years of age * patients will be recruited only if cancer-free at clinical evaluation time. * for the cases a confirmed tc diagnosis who received one or more cycles of cbct-based chemotherapies (cbct group, arm 2) * for the cases with a confirmed tc diagnosis who received one or more cycles of cbct-based chemotherapies and underwent bmt for relapsed refractory disease (cbct \& bmt group, arm 3). * for the comparison cohort, biopsy-proven tc patients who had surgery for or surveillance of their testicular cancer and never received cbctcbct or bmt (surgical/surveillance, arm 1) exclusion criteria * prior known myocardial infarction (mi), atherosclerotic cardiovascular disease (ascvd) * significant renal disease (gfr\<40) * allergy to iodinated contrast * antecedent chemotherapy for another primary cancer.
efficacy and safety study of botulinum toxin type a against placebo to treat spasticity in the leg after a stroke

Conditions: Post-stroke Spasticity of the Lower Limb

Summary: the purpose of this study is to determine whether injections of botulinum toxin type a into muscles of the leg are effective in treating patients with increased muscle tension/uncontrollable muscle stiffness (spasticity) after a stroke.


Eligibility criteria:
inclusion criteria: * age from 18-80 yrs * lower limb spasticity * time since stroke greater than 3 months * need for 400 u botulinum toxin type a exclusion criteria: * body weight below 50kg * fixed contractures of the lower limb * generalized disorders of muscle activity like myasthenia gravis that preclude use of botulinum toxin type a * infection at the injection site