Kornimate/medical-research-clean huggingface dataset:
transitioning to a valve -gated intrathecal drug delivery system (idds)

Conditions: Chronic Pain; Intractable Pain; Back Pain

Summary: flowonix prometra® ii programmable pump may require a smaller dose of drug when converting from other commercially available intrathecal drug delivery systems (idds).

this open-label, non-randomized, single-blind, multi-center study is designed to evaluate effects of a planned 20% dose reduction when converting to valve-gated from a peristaltic pump. study participants will be blinded (single blind) to the dose reduction aspect of this trial and must remain blinded to this dose reduction information throughout the trial in an attempt to provide an unbiased assessment of the pain encountered by the patient with their pain pump medications used. this study will compare the historical pain medication dose and pain scores using the peristaltic pump at baseline as well as from the last pump refill visit prior to explant to the prospective pain medication dose and pain scores using the valve-gated pump and collected at refill visits 1, 2 and 3 after valve-gated pump implant (but not exceed 12 months).

Eligibility criteria:
inclusion criteria: 1. be male or female between the ages of 22 and 85 years 2. be capable of giving informed consent and completing assessments required by the study 3. have pain intensity of greater than 5 out of 10 as measured by vas 4. have an active existing peristaltic intrathecal drug delivery system 5. have stable drug dosage for at least 6 weeks prior to valve-gated pump implant 6. be an appropriate candidate for surgery 7. be able to comply with required study visits and assessments including english proficiency exclusion criteria: 1. have a significant pain disorder not intended to be treated with the test device or comparator 2. be terminally ill and/or have a life expectancy of less than 6 months 3. be a pregnant/lactating woman or a woman of child-bearing potential 4. have a systemic or local infection (contraindicated for pump implantation) 5. have history/evidence of an active disruptive psychiatric disorder or other known condition with potential to impact compliance with study visits and assessments 6. have an underlying condition increasing susceptibility to infection
correlation between anthropometric measurements and balance in children with cerebral palsy

Conditions: Anthropometric Measurements&Balance IN CP Children

Summary: the purpose of the current study is to evaluate the correlation between anthropometric measurement (weight, height and bmi) and balance in children with cerebral palsy.

* the european society for clinical nutrition and metabolism has pointed out that under-nutrition can led to change in body composition (e.g. depletion of body fat mass) and diminished function and outcome. * the prevalence of under-nutrition in children with cp varies from 3.9 per cent to 71 percent mainly depending on the method of assessment, the severity of motor involvement and feeding problems. * studies indicate that children and adults with both mild and severe forms of cp have postural impairments. dysfunctional posture control interferes with the activities of daily life . * children with cp may have impaired muscle tone and abnormal postural control, both of which affect functional balance capacity. * there were associations between excess body weight and values below normal in some balance conditions, indicating that the anthropometric indicators interfered in the children's postural balance. there were associations between excess body weight and values below normal in some balance conditions, indicating that the anthropometric indicators interfered in the children's postural balance. knowledge of anthropometric measurements and whether they affect balance in children with cp will help clinicians to develop treatment programs which in turn will improve the overall balance and functional abilities of children with cp. * childeren age will be ranged from 8-12 years and on level ⅰ and ⅱ on growth motor function classification system * weight would be obtained on a digital scale (uniscale ) * standing height was measured using a stadiometer with a fixed vertical backboard and an adjustable head piece. * cdc 2000 charts will be used to measure bmi * the biodex balance system will be used for the assessment of static and dynamic balance of all children

Eligibility criteria:
inclusion criteria: 1. their age will be ranged from 8 to 12 years. 2. the degree of their spasticity will be ranged from 1 to 2 according to modified ashworth' scale. 3. they will be on level ⅰ and ⅱ on growth motor function classification system (gmfcs). 4. they will be able to stand without the use of an assistive device 5. children can follow instructions and understand given orders. exclusion criteria: 1. severe visual or hearing impairment. 2. fixed deformities or surgical interventions in the lower extremities. 3. botulinum toxin injections in the last 6 months.

Keywords: anthropometric measurements balance cerebral palsy
chronic obstructive pulmonary disease (copd) history assessment in spain (chain)

Conditions: COPD

Summary: the research project chain (copd assessment history in spain): "a multidimensional study on the evolution of chronic obstructive pulmonary disease (copd)is a multicentre, observational study conducted in several areas of spain aimed to better define copd natural history and its phenotypes

observational studies are needed to ascertain the natural history and progression of copd, and to better define its phenotypes. these two aspects are considered fundamental to a proper evaluation of current (and future) copd treatment options, and it could possibly justify the limited impact of recent major drug trials. currently, there remain gaps in the natural history of patients with copd. most data are from analysis of mild copd patients or smokers, usually measuring only fall in fev1, and both have significant limitations in design and interpretation. studies in more severe patients with copd have also been conducted mainly by studying lung function, possibly influenced by the recommendations of current guidelines for disease management. in recent years, we have more longitudinal data on changes in exercise capacity, imaging, and biomarkers, among other variables of interest, but our knowledge is yet partial. the research project chain (copd assessment history in spain): "a multidimensional study on the evolution of chronic obstructive pulmonary disease (copd) is a multicenter observational study that will follow prospectively two cohorts: a) a copd group active or former smokers (copd cohort) and b) a group of active smokers or former smokers without copd (control cohort). both cohorts will be followed up for a period of at least 5 years, with visits every 12 months (and phone controls at least every 6 months). we will try to extend the monitoring of the cohort up to 10 years. chain is supported by the pii of copd separ

Eligibility criteria:
inclusion criteria: * patients ≥ 35 years. * diagnosis of copd (gold pbd fev1/fvc ratio \<0.70). * being in a stable phase of disease (8 weeks without exacerbation). * cummulative smoking ≥ 10 pack-years. * absence of asthma or other chronic respiratory disease that justify the ventilatory disorder (although a history of asthma is not an exclusion criteria); * absence of malignancy or very serious comorbidities that would prevent study completion. exclusion criteria: * patients \<35 years. * recent exacerbation (\<8 weeks). * not giving written informed consent. * presence of asthma or other chronic respiratory disease justifying the ventilatory disorder, * diffuse bronchiectasis not associated with copd. * presence of malignancy or very serious comorbidities that would prevent study completion. * difficulty to perform appropriate follow-up.

Keywords: cohort copd natural history phenotyping smoking
implication of a mobile team of palliative care and reality of the palliative approach in the units

Conditions: Death; Palliative Care

Summary: the aim of the study is to estimate the impact of the implication of a mobile team of palliative care (emsp) on the palliative strategy in the units with concerned patients. the mobile team of palliative of foch hospital care was created in march, 2011.


Eligibility criteria:
inclusion criteria: * patients died between july, 2013 and september, 2014 and for which at least one opinion of the emsp was required exclusion criteria: * none
study of multiple oral dosing to evaluate the safety and the pharmacokinetic drug-drug interaction of telmisartan/amlodipine and rosuvastatin in healthy male volunteers

Conditions: Hypertension and Dyslipidemia

Summary: a non-randomized, two-arm, single-sequence, crossover, open label, multiple oral dosing clinical trial to evaluate the safety and the pharmacokinetic drug-drug interaction of telmisartan/amlodipine and rosuvastatin in healthy male volunteers


Eligibility criteria:
inclusion criteria: * healthy male who are ≥19, \<50 years old * man who weights over 55kg and whose bmi is 18\~30(kg/m2) * man who doesn't have any chronic disease or history of disease exclusion criteria: * man who has or had any clinically relevant disease of liver, kidney, nervous/respiratory/musculoskeletal/cardiovascular/hemato-oncology system or neuropsychiatry
effect of hbo on functional connectivity of resting state networks in patients with cerebral small vessel disease

Conditions: Encephalopathy; White Matter Hyperintensities; Impaired Oxygen Delivery

Summary: the purpose of this study is to extend our previous work, in which we demonstrated an increase in the internal and cross network connectivity of resting state neural networks in patients with cerebral small vessel disease by treatment with hyperbaric oxygen, to at least 20 more individuals.

patients without contraindications to hyperbaric oxygen treatment or magnetic resonance imaging who exhibit white matter hyper-intensities on mri will be recruited to have a functional mri followed by10 hyperbaric oxygen treatments at 2 ata for one hour. these treatments will be done once daily, from monday through friday, on 2 consecutive weeks. 4-6 weeks later, they have a repeat fmri. these fmri's will be analyzed regarding any changes in the resting state connectivity of various circuits.

Eligibility criteria:
inclusion criteria: over 50 years of age white matter hyperintensities on mri @ or more symptoms and/or neurological impairments e.g. gait disturbances,disequilibrium, decline in cognitive function, upper motor neuron deficit, dysmetria, hyper-refexia or unilateral increase in motor tone - exclusion criteria: contraindications to hyperbaric oxygen therapy e.g. pulmonary emphysema or bullae, claustrophobiia, seizure diorder inability of the patient to tolerate pressurization e.g. eustachian tube dysfunction stroke within the previous 6 months extreme cognitive impairment major depression other uncontrolled co-morbidities, e.g. diabetes, hypertension, thyroid disorders, carotid artery stenosis (\>70%), renal or hepatic dysfunction history of brain tumor, head trauma, electric shock therapy, brain irradiation history of migraine headaches -

Keywords: hyperbaric oxygen small vessel disease of the brain impaired brain circuit connections
a community setting study of malaria after systematic treatment of symptomatic carriers of p. falciparum with coa566 (coartem®)

Conditions: Malaria

Summary: this study assessed the impact of the systematic detection by rapid diagnostic test (rdt) and treatment of asymptomatic carriers of malaria parasites (p. falciparum) with coa566 on a number of clinical malaria cases in children less than 5 years of age and the improvement of hemoglobin levels in the overall population.


Eligibility criteria:
inclusion: * subjects who were diagnosed as asymptomatic carrier (ac) by rapid diagnostic test (rdt). * subjects who were diagnosed with a symptomatic malaria episode, rdt-confirmed (smrc) exclusion: * body weight \<5 kg. * hypersensitivity to artemether-lumefantrine or to any of the excipients of the tablets or dispersible tablets. * presence of severe malaria signs and symptoms * first trimester of pregnancy. * family history of congenital prolongation of the qtc interval or sudden death or with any other clinical condition known to prolong the qtc interval such as history of symptomatic cardiac arrhythmias, with clinically relevant bradycardia or with severe cardiac disease. * taking drugs that are known to influence cardiac function and to prolong qtc interval, such as class ia and iii: neuroleptics, antidepressant agents, certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones, imidazole and triazole antifungal agents, certain non-sedating antihistamines. * known disturbances of electrolyte balance, e.g. hypokalemia or hypomagnesemia. * taking drugs which may be metabolized by cytochrome enzyme cyp2d6

Keywords: p. falciparum malaria asymptomatic carriers bed-nets itn-insecticide-treated net idiopathic trigeminal neuralgia rdt-rapid diagnostic test
ocular ultrasonography as a tool for monitoring the management of traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: raised intracranial pressure (icp) is a common and life threatening condition especially in patients with traumatic brain injury.there are many methods for monitoring the increased (icp) either invasive or non- invasive ,but the gold standard is invasive method. optic nerve sheath ultrasonography provides a very promising bedside tool for detection of increased icp. this study will monitor the dynamic changes of intracranial pressure by optic nerve sheath diameter (onsd) in response to mannitol osmotherapy

traumatic brain injury is the main cause of increased intracranial pressure (icp) in the intensive care . there are multiple methods for monitoring the raised icp either invasive or non-invasive.the gold standard is the invasive devices because it is more accurate and reliable .however ,it requires a surgical intervention which has many hazards such as (infection ,hemorrhage,malfunction ). optic nerve sheath ultrasonography is a promising bedside tool for detection of increased icp. the optic nerve is surrounded by cerebro-spinal fluid ,thus if the circulation of cerebro-spinal fluid not blocked ,an increase in icp will be transmitted through the subarachnoid space around the optic nerve within the nerve sheath especially the retro-bulbar segment. the study will be conducted to monitor the dynamic changes of intracranial pressure by optic nerve sheath diameter (onsd) in response to mannitol osmotherapy as a primary outcome and secondary to evaluate the efficacy of onsd in assessing the severity of the disease

Eligibility criteria:
inclusion criteria: * patients with traumatic brain injury exclusion criteria: * patients with history of optic neuritis * past history of eye trauma * patient with optic nerve trauma * patient with history of arachnoid cyst of the optic nerve * high myopic patients * patients with cavernous sius mass
pityriasis lichenoides : anatomo-clinical aspects and follow-up

Conditions: Pityriasis Lichenoides

Summary: introduction: pityriasis lichenoides (pl) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state. the current classification is confusing because it mixes semiological and chronological notions. the objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of pl in an adult population. methods: investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of pl from the coding of the department of pathology of henri-mondor hospital and from medical records and photographs of lesions if available, between january 2012 and august 2018. a follow-up telephone interviews will also be proposed to each patient to collect evolution data. photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed. conclusion: investigators would like to better understand clinical, histological features and evolutionary aspects of pl in an adult population.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients with pityriasis lichenoides selected from histological coding ot0431, seen at henri mondor and with a diagnosis verified from medical records. exclusion criteria: * histological coding error * histological records of patients in care outside henri mondor (cases referred for histological expertise only but not seen clinically) * clinical lesions incompatible with pityriasis lichenoides according to classically published semiological data * missing or insufficient medical records for data exploitation

Keywords: pityriasis lichenoides; cutaneous lymphoma lymphoproliferation
blueberry consumption and type 2 diabetes

Conditions: Type2 Diabetes

Summary: lifestyle strategies that include dietary modification, such as consumption of a plant-based diet, are well recognized in disease prevention and may improve type 2 diabetes. various components of a plant-based diet may contribute to its beneficial health effects, but there has been keen interest in the possibility that plant polyphenols may have a role. blueberries are dietary sources of polyphenols, specifically anthocyanins. to date there are few human clinical trials evaluating the beneficial health effects of blueberries in populations with type 2 diabetes. the objective of the study is to determine if freeze-dried blueberries compared to a blueberry placebo will improve cardiometabolic parameters in men with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * male * ages 45 to 75 years at beginning of study * bmi \>25 kg/m2 * hba1c \> 6.5 and \< 9 * medical diagnosis of type 2 diabetes for at least 6 months exclusion criteria: * use of insulin * presence of chronic kidney disease (gfr \< 45 ml/min), liver cirrhosis, gastrointestinal disease, pancreatic disease, or malabsorption syndromes * weight loss of \>10% of body weight over the last 6 months; routine participation in heavy exercise * heavy smokers (\>20 cigarettes per day) * unable or unwilling to give informed consent or communicate with study staff * other medical, psychiatric, or behavioral factors that in the judgment of the principal investigators may interfere with study participation or the ability to follow the intervention protocol * allergies to blueberries or blueberry products
late respiratory consequences of sars-cov-2 pneumonia

Conditions: Respiratory Function Tests; Long COVID

Summary: the goal of this observational study is to learn about the respiratory system in post-covid syndrome. the main question aims to answer: how the post-covid syndrome alters the lung function participants will be asked to perform lung function tests. researchers will compare post-covid group to matched control healthy individuals.


Eligibility criteria:
inclusion criteria: covid-19 infections in the post-covid group. - exclusion criteria: -
anatomical and biomechanical study about stability in galeazzi´s fracture

Conditions: Galeazzi's Fracture

Summary: most galeazzi fractures can be treated adequately with open reduction and internal fixation (orif) of the radius alone, but some will remain unstable at the druj and require repair of the tfcc.the purpose of this anatomical and biomechanical study was to define and measure druj dislocation, displacement and instability associated with the sequential sectioning of the different bands in the interosseous membrane (iom) and tfcc in the simulation of a galeazzi fracture.

instability of the druj is a common clinical problem associated with galeazzi fracture. stability of the druj is primarily provided by both the bony anatomy of the sigmoid notch of the radius and ulnar head and the soft tissues surrounding the joint. the interosseous membrane plays an important role in druj stability but the tfcc is the major soft tissue stabilizer of the druj. the central band works as a restraint on the radius from proximal migration in cooperation with the radial head and the tfcc and also works as a load transmitter between the radius and ulnar to redistribute load. some investigators suggested that the distal membranous portion and dob stabilizes the druj when tfcc is disrupted. watanabe et al. (2005) insisted on the importance of dob, which constrained volar and dorsal instability of the radius at the druj in all forearm rotation positions. the purpose of this anatomical and biomechanical study was to define and measure druj dislocation in the simulation of a galeazzi fracture.

Eligibility criteria:
inclusion criteria: adults patients(18-85 years old) with galeazzi fracture-dislocation treated with open reduction and internal fixation (orif). exclusion criteria: * children * other types of forearms fractures
virtual reality in copd exacerbation

Conditions: COPD Exacerbation; Pulmonary Rehabilitation

Summary: in addition to conventional pulmonary rehabilitation, virtual reality will be applied during the hospitalization period of individuals hospitalized for copd exacerbation. it is aimed to get more efficiency from the interventions in this short time.

subjects with copd exacerbation will be divided two groups. group-1 will exercise with a bicycle ergometer until fatigue in addition to pulmonary rehabilitation. group-2 will do the same exercises. subjects in group-2 will use virtual reality simulation, which is designed as cycling in the forest while cycling. treatment will continue until discharge. cat score, mmrc dyspnea score, hospital anxiety and depression score and london chest daily living activity score will be examined before and after treatment.

Eligibility criteria:
inclusion criteria: * individuals who are in copd exacerbation period, fev1 \ 6 and who want to participate in the study voluntarily will be included in the study. exclusion criteria: * if there is respiratory disease considered more significant than copd (bronchiectasis, lung cancer requiring active therapy, or asthma), heart failure new york heart association (nyha) stage 3-4, significant hemoptysis, surgical or non-surgical lung volume in the past 6 months individuals with reduction procedures, lung transplantation or pneumonectomy surgery in the last 6 months, pulmonary embolism or pulmonary edema, acute myocardial infarction, acute heart failure, vertigo, epilepsy and visual impairment will be excluded from the study.

Keywords: copd, pulmonary rehabilitation, virtual reality