Kornimate/medical-research-clean huggingface dataset:
mechanical bowel preparation with or without oral antibiotics for colorectal cancer surgery

Conditions: Antibiotic; Bowel Cancer; Colorectal Cancer; Surgical Site Infection

Summary: investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.

the aim of the study is to investigate whether the addition of oral antibiotics to mechanical bowel preparation (mbp) prior to colorectal cancer surgical procedures reduce the superfical and deep surgical site (ssi) infectious complications. the study is prospective and is designed in a randomized single-blinded controlled fashion. it is taking place at one academic surgical unit of athens medical school, located at a tertiary referal institution. patients scheduled to undergo an elective surgical resection for colon or rectal cancer will be allocated to either formal mbp the day before surgery or a combined mbp with administration of oral antibiotics. exclusion criteria are the following: emergency surgery, obstructive or perforated cancer, patients intolerance to bowel preparation regimen and allergies to orally administered antibiotics. intervention arms: patients will be randomised into two groups, concealed from the treating surgeon. group a: preoperative oral antibiotic therapy with rifaximin 400 mg plus metronidazole 500mg the day prior to surgery at 2:00, 3:00 and 10:00 pm, with mbp (2 vials sodium phospate 45ml at 1:00 and 7:00 pm) group b: mbp (2 vials sodium phospate 45ml at 1:00 and 7:00 pm) alone both groups will receive iv antibiotics (cefoxitin 2 gr plus metronidazole 500gr) perioperatively and discontinuation within 24 hours. outcome measures: the primary end point is surgical site infection (ssi), including (i) superficial wound infection, (ii) deep wound infection, and (iii) intrabdominal infection (contaminated fluid or pus collection) within 30 days of the procedure (decrease 3% in the rate) secondary measures: anastomotic leaks, other surgical and non-surgical compliactions, hospital length of stay, readmission rate, patients' preparation tolerance, preparation regimens side-effects, time to beginning of adjuvant treatment for colorectal cancer. sample size: it is estimated that 105 patients per treatment arm are needed.

Eligibility criteria:
inclusion criteria: * scheduled colorectal cancer surgery exclusion criteria: * emergency surgery * obstructive and perforated cancer * intolerance to bowel preparation regimen * allergies to orally administered antibiotics

Keywords: oral antibiotic mechanical bowel preparation colorectal cancer surgical site infection
"react-fm-ext": real-world evidence from smartphone-based acceptance and commitment therapy in fibromyalgia: an extension study

Conditions: Fibromyalgia

Summary: this is an extension study of react-fm. the primary objective of the study is to assess the response to digital therapy in the treatment of fibromyalgia over an additional 9 months.


Eligibility criteria:
inclusion criteria: * participant has completed participation in the react-fm study. * participant has completed 41 sessions within tempo in the react-fm study and is willing and able to comply with all protocol-specified requirements. * participant has provided informed consent to participate. * participant continues to meet original safety criteria for the react-fm study. exclusion criteria: * none
qutenza (topical capsaicin 8%) for painful arteriovenous fistulae

Conditions: Neuropathic Pain; Arteriovenous Fistulae

Summary: arteriovenous fistulae are artificial connections between the artery and vein in the arm which allow needles to be inserted for haemodialysising patients wit kidney failure. occasionally severe debilitating pain can arise from these fistulae for which no cause can be found. such pain can be very difficult to treat. many commonly used used painkillers are known to cause significant side effects in patients with renal failure (drowsiness, confusion etc. qutenza (topical capsaicin 8%) is a new treatment made from chilli peppers which is applied to the skin as a patch and works directly at the nerve endings in the skin to prevent pain. it therefore should not have the systemic side effects of other drugs. it has been demonstrated to be beneficial in other painful conditions for example post-shingles pain and nerve pain from hiv. it has never been used for critical ischaemia before. we propose to investigate the efficacy of qutenza in treating patients with end stage renal failure and chronic pain from their fistulae (avf). we will recruit 20 patients with painful avf and treat them with qutenza. we will follow them up for 12 weeks and monitor the change in their pain scores.


Eligibility criteria:
inclusion criteria: * all adult patients \>18 years old with end stage renal disease on dialysis and significant chronic neuropathic pain arising from their arteriovenous fistula (defined as pain with symptoms to suggest a neuropathic element occurring most days for at least a month which has not responded to simple analgesia) exclusion criteria: * pre-dialysis * underlying anatomical/ structural abnormality with avf contributing to pain * diabetic neuropathy resulting in sensory loss * hypersensitivity to qutenza, emla or any of the excipients * broken skin or active ulceration at the site of application * severe uncontrolled hypertension (systolic bp \>200) * proven cardiac event during the preceding 3 months * women who are pregnant or breast feeding * lack of capacity or inability to provide informed consent * declines participation in the study

Keywords: neuropathic pain arteriovenous fistulae end stage renal disease
comparison of different treatment methods in lumbal disc herniation treatment

Conditions: Lumbar Disc Herniation

Summary: the aim of this study is to determine the effectiveness of three different treatment methods which consists spinal decompression, deep friction massage and exercise. the patients were separated three groups group one received non-surgical spinal decompression therapy, group two received non-surgical spinal decompression, lumbar stabilization exercises and manual therapy, group three received manual therapy and lumbar stabilization exercises. all groups completed 15 sessions of therapy. in each session, pain severity was assessed with numeric analog scale, straight leg raise test applied and the degree of the hip flexion where the patient reported pain were recorded, respectively. static, dynamic muscle strength-endurance tests were applied before the treatment sessions started, after the treatment sessions ended, six weeks after and three months after the study. oswestry disability scale (odi), back performance scale (bps), lanss neuropathic pain questionnaire, fear-avoidance-beliefs questionnaire (fabq) and mcgill pain questionnaire were applied before the treatment sessions started, after the treatment sessions ended and three months after the study. gradient of disc height and thickness of the herniation were assessed segmentally with magnetic resonance imagination (mri) before the study and three months after the study.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of lumbar disc herniation without strengthening loss exclusion criteria: * clinical diagnosis of osteoporosis * have scoliosis and spondylolisthesis * any surgery related spine * any neurological diseases causes sensory loss

Keywords: exercise deep friction massage spinal decompression non-surgical spinal decompression
study of a national cohort of adult patients with phenylketonuria

Conditions: PKU; Hyperphenylalaninemia

Summary: phenylketonuria (pku) is a metabolic disease of genetic origin. this is a rare disease (incidence 1 / 16000 births) which is the subject of a systematic neonatal screening in france, because it is treatable by a diet low in phenylalanine. this plan is required upon confirmation of diagnosis and continued until the age of 8 years. the current trend is to continue the scheme at least until adolescence. unlike other countries, in france there are no recommendations for a plan "for life". knowledge about the natural history of pku in adulthood, the effects of pediatric age, the frequency of complicated shapes, and prognostic factors are poorly documented. on the other hand, there is no consensus on the therapeutic management of this disease in adulthood and monitoring that could be directed towards the detection of neurological disorders and nutrition. social integration and quality of life of adults pku patients living in france have not been studied.

the aim off this study is to follow a french cohort of young adult patients with pku to: * describe the evolution of the disease in adulthood and neurological complications associated neuropsychological detect, investigate the prognostic factors for complications * describe the metabolic balance of patients * collect data on nutritional status, * detect osteoporosis * studying social integration and quality of life of adult patients with pku * collect biological samples for further study (markers of bone turnover) design: cohort : duration of the inclusion period: 2 years duration of subject participation: 5 years total duration of the study: 7 years judging criteria: * complications associated with pku in adult * evolution of neuropsychometric scores * bone mineral density by densitometry * measuring the quality of life of patients

Eligibility criteria:
inclusion criteria: * patient age ≥ 18 years * phenylketonuria (pku) or moderate persistent hyperphenylalaninemia (hmp) diagnosed by neonatal screening * reading and signing an informed consent * membership of a social security system exclusion criteria: * history of severe neurological definite diagnosis could interfere with the detection of neurological disorders associated with pku

Keywords: pku osteoporosis hmp life quality neuropsychological nutritial evaluation phenylketonuria hyperphenylalaninemia
how does prostate cancer metastasize? studying the role of secreted packages (exosomes) from fat tissue in lean and obese patients

Conditions: Prostate Cancer; Obesity

Summary: the investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.

both obesity and prostate cancer are major health problems in the uk, affecting 1 in 3 and 1 in 8 men respectively. moreover, obesity increases the risk of developing aggressive disease and the risk of prostate cancer spreading. how this happens is not known. the investigators want to understand how fat cells communicate with prostate cancer cells. investigators will be collecting prostate and fat tissue from radical prostatectomy participants for culture, in particular to look at exosome communication.

Eligibility criteria:
inclusion criteria: * all men undergoing radical prostatectomy at charing cross hospital exclusion criteria: * patients unable to consent

Keywords: prostate cancer obesity exosomes
effect of allopurinol or febuxostat to prevent contrast induced acute kidney injury (ci-aki)

Conditions: Contrast-induced Nephropathy; Contrast-induced Acute Kidney Injury

Summary: a randomized, placebo-controlled, double-blind clinical trial of effect of allopurinol or febuxostat to prevent contrast induced acute kidney injury (ci-aki)

eligible patients (patients with glomerular filtration rate \< 60 ml/min or high riks patients based on mehran score) that will be undergoing cardiac catheterization/intervention randomly assigned to receive allopurinol 300 mg or febuxostat 80 mg 12 hours before and 12 after 1 exposure of radiocontrast and iv hydration (normal saline 1 ml/kg/hr 12 pre and post radiocontrast exposure) or placebo and hydration. exclusion criteria: patients under treatment with allopurinol or febuxostat in the previous seven days, known allergy to allopurinol or febuxostat, patients on renal replacement therapy

Eligibility criteria:
inclusion criteria: * age 18 years and older who are scheduled to coronary intervention * patients with mehran score \> 5 or modified mehran score \>2 even glomerular filtration rate \> 60 ml/min (high risk patients) * glomerular filtration rate \< 60 ml/min * all the patients provided written informed consent for the procedures and the test drug exclusion criteria: * patients with shorter hospital stay (\<48 hours) * patients under treatment with allopurinol of febuxostat * patients on renal replacement therapy * known allergy to allopurinol or febuxostat

Keywords: contrast induced acute kidney injury contrast induced nephropathy allopurinol febuxostat
effect of topical dexmedetomidine on intraocular pressure

Conditions: Glaucoma; Intraocular Pressure

Summary: evaluate the short-term safety and efficacy of dexmedetomidine (0.0055%) drops on intraocular pressure (iop) in healthy eyes.


Eligibility criteria:
inclusion criteria: * patients with healthy eyes and no history of glaucoma exclusion criteria: * history of glaucoma, iop \> 24mmhg at baseline, abnormal optic nerve on fundus examination, keratoconus, corneal graft, corneal edema or a history of refractive surgery
to study the incidence and outcome of paracentesis induced circulatory dysfunction in decompensated cirrhotics undergoing less than 5 litres of ascitic fluid tap with or without albumin infusion.

Conditions: Decompensated Cirrhosis

Summary: all consecutive patients admitted in ilbs from may 2015 to december 2016. decompensated cirrhosis patients will be randomized into group 1: mvp (moderate volume paracentesis) of less than 5 litres with iv albumin at a dose 8 gms/l of ascitic fluid group 1: mvp (moderate volume paracentesis) of less than 5 litres without albumin .


Eligibility criteria:
inclusion criteria: 1. all cirrhotics decompensated with ascites admitted in the hospital. 2. grade ii/iii ascites 3. need for paracentesis. exclusion criteria: 1. age \ 75 years 2. hepatocellular carcinoma 3. non cirrhotic ascites such as malignancy or tubercular peritonitis 4. serum cr \>1.5mg% 5. refractory septic shock 6. grade iii/iv hepatic encephalopathy 7. abdominal wall cellulitis 8. active variceal bleed 9. respiratory, cardiac and renal failure 10. refusal to participate in the study
sense of coherence and empowerment at patients with mups

Conditions: Medically Unexplained Symptoms; Sense of Coherence

Summary: this is a study on metacognitive therapy in general practice in norway. the intervention is a small pilot study to examine whether metacognitive therapy is feasible in an ordinary general practice. will the physicians be capable to learn and provide the therapy method for their patients with mups and is is possible to implement this in an ordinary general practice routine? both physicians and their patients will be asked to respond to a questionnaire on perceived utility of the treatment.

metacognitive therapy is different from cognitive therapy in the sense that it adresses the individual's attention towards potential worries and threats and also the management performed by the patient to avoid these. also the individual's capacity to produce empowerment to manage these threats are of interest in the talks with the health care provider. - in this study, general practitioners with specific training in metacognitive therapy will be asked to recruit 2-3 patients with medically unexplained physical symptoms each and invite them to a series of metacognitive therapy. the patients and physicians will then provide their assessments of the treatment on a number of questionnaires. to explore the sense of coherence and empowerment among patients with medically unexplained symptoms, the physicians will be asked to recruit six patients each to respond to a questionnaire.

Eligibility criteria:
inclusion criteria: * mups: medically unexplained physical symptoms * somatic and mental examination sufficiently accomplished * ongoing symptoms * more than three months of disabeling symptoms exclusion criteria: * not capable to respond on a written questionnaire in norwegian
caregiver burden in cerebral palsy undergoing hip and knee surgery

Conditions: Cerebral Palsy; Care Giving Burden

Summary: the aim of this observational study was to obtain information about the change in the burden of care of parents of children with cerebral palsy after hip and knee surgeries. the main questions it aims to answer are: q1-does caregiver burden change after hip and knee surgeries? q2-if so, which factors contribute more positively to this situation? participants will be asked to answer the scales given to them periodically before and after the surgery.

one of the most common causes of disability in childhood is cerebral palsy, which develops due to damage to the central nervous system. children diagnosed with cerebral palsy face different problems in every period of their lives. the child, his/her family and the society he/she lives in should be considered as a whole. there is a mechanism that mutually affects each other. parenting, caring for and living with a child with cerebral palsy can have many negative effects on the lives of parents and create additional burdens for them. parents may have to choose between their own needs, the needs of other members of the family and the needs of the child with cerebral palsy, and may spend most of their time with their disabled child. this can negatively affect the burden, stress level, physical activity level, quality of life, psychological status and self-efficacy perception. the primary aim of this study is to evaluate the caregiver burden in cerebral palsy, which is the most common cause of morbidity in the pediatric age group in orthopedics, and to analyze the factors that negatively affect it. our hypothesis is that the functional mobilization status of patients will increase, especially as a result of hip surgeries, reducing caregiver burden.

Eligibility criteria:
inclusion criteria: 1. parent age a. being in the 20-60 age group. 2. diagnosis 1. having a child with clinically diagnosed cerebral palsy 2. the movement scale of the cerebral palsy patient is between gmfs 3 and 5 3. a minimum follow-up of 12 months after surgery 4. the primary carer is the mother or father exclusion criteria: 1. the patient and his/her family have been lost to follow-up 2. having another disabled person in need of care in the family 3. family's unwillingness to participate in the study 4. loss of a parent
comparative analysis of the lung inflammatory response after thoracic surgery with single or double lung ventilation: a randomized, pilot, trial

Conditions: Thoracic Diseases; Surgery

Summary: the goal of this clinical trial is to compare in patients undergoing thoracic procedures the lung inflammatory response in on one-lung ventilation and two-lung ventilation strategies the main question to answer is: • lung inflammation differs when comparing one to two-lung ventilation strategies during the procedure? participants will be divided in the classic one lung ventilation or two lung ventilation (using pneumothorax with co2) and different biomarkers of lung inflammation will be measured after procedures.


Eligibility criteria:
inclusion criteria: * a diagnosis of pleural or mediastinal pathology that requires diagnostic or therapeutic surgical intervention; * written consent to participate exclusion criteria: * pregnant women; * patients on mechanical ventilation prior to the procedure; * patients classified by the american society of anesthesiology (asa) as class 4; * patients with subpulmonary or diaphragmatic pathologies, where it is believed that the two pulmonary technique is superior; * impossibility of using a double-lumen tube or difficult intubation; * patient does not support one-lung ventilation; * patient with previous lung resection surgery
prevalence and risk factors in unipolar depression patients without remission after one antidepressant trial

Conditions: Non-psychotic Unipolar Major Depression

Summary: a non interventional, descriptive, longitudinal cohort study is designed, trying to obtain local data about the prevalence of non remitted depressed patients after an antidepressant treatment, and to get information about sociodemographic and clinical characteristics of these patients as well as features of their treatments and compare them with those of the patients that achieve remission. also the effect of patient´s expectation in the treatment outcome will be examined.

a non interventional, descriptive, longitudinal cohort study is designed, trying to obtain local data about the prevalence of non remitted depressed patients after an antidepressant treatment, and to get information about sociodemographic and clinical characteristics of these patients as well as features of their treatments and compare them with those of the patients that achieve remission. also the effect of patient´s expectation in the treatment outcome will be examined. non psychotic depressed patients that are initiating an antidepressant treatment will be recruited. socio demographic and clinical features will be recorded as well as their expectations before the treatment. severity of depression and treatment characteristics will be recorded after 4 to 8 weeks of drug treatment at an adequate dose. variables will be compared between the patients that will achieve remission and those that do not.

Eligibility criteria:
inclusion criteria: female and male aged 18 to 75 years old. outpatients with a current episode of non-psychotic unipolar major depression according to the dsm iv-tr. severity of illness assessed by means of a score ≥ 14 in the ham d17 have not been medicated for the current depression episode with an antidepressant provision of subject informed consent exclusion criteria: patients participating in any clinical trial, the subject cannot take part in this study. the individual has participated in the last 3 months (including this study) or is participating in a clinical trial.

Keywords: non-psychotic unipolar major depression resistant depression
gender/sex & cud remission

Conditions: Cannabis Use Disorder, Mild; Cannabis Use Disorder, Moderate; Cannabis Use Disorder, Severe

Summary: adults (ages 18+) who would like to reduce their cannabis use (n=224) will be enrolled in an 8-week treatment program. all participants will receive counseling (1 goals session with a therapist followed by 7 weekly computerized cognitive-behavioral therapy sessions). detailed cannabis assessments (biological and self-report) will be conducted throughout treatment and at 1-, 2-, and 3-months post-treatment completion. daily electronic diaries will be administered via text message to record detailed logs of cannabis use quantity and frequency. salivary samples will be collected (and video observed) daily throughout treatment to analyze for progesterone.


Eligibility criteria:
inclusion criteria: 1. willingness to participate in a research study (otherwise, will be referred to appropriate clinical services if seeking clinical care). 2. meet current (within last 30 days) dsm-5 criteria for cannabis use disorder. 3. submit a positive urine cannabinoid test during screening. 4. interested in treatment for cannabis use disorder. exclusion criteria: 1. significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation. 2. the presence of any substance use disorder requiring a higher level of care. 3. significant risk of homicide or suicide. 4. pregnant, trying to become pregnant, or breastfeeding.