Kornimate/medical-research-clean huggingface dataset:
accelerated partial breast irradiation with imrt in early breast cancer

Conditions: Breast Neoplasms; Neoplasm Recurrence, Local

Summary: this study is to evaluate the efficacy and toxicity of accelerated partial breast irradiation (abpi) with intensity modulated radiation therapy (imrt) in low-risk breast cancer treat with breast-conserving surgery.

this study is a national multicenter phase ii prospective clinical trial to enroll low-risk breast cancer treat with breast-conserving surgery. all eligible patients will receive abpi to a total dose of 40gy, in 10 fractions, 4gy/fx/day, within 2 weeks. intensity modulated radiation therapy (imrt) technique is used. during follow up, the locoregional recurrence,survival,acute and late adverse events,and quality of life will be prospectively evaluated.

Eligibility criteria:
inclusion criteria: * life expectation: \> 5 years * enrollment date no more than 12 weeks after breast-conserving surgery or no more than 8 weeks after adjuvant chemotherapy * histologically confirmed diagnosis of invasive ductal carcinoma (grade 1-2), or mucinous carcinoma, or papillary carcinoma, or tubular carcinoma, or medullary carcinoma: primary tumor ≤ 3.0cm in maximum diameter and pn0; or histologically confirmed dcis: primary tumor ≤ 2.5cm in maximum diameter, low-medium grade * unifocal tumour (confirmed by diagnostic mri) * no lymphovascular invasion * er positive (defined as medium-strongly nuclear staining in \>1% of the cancer cells) * negative radial resection margins of \>= 2 mm * surgical clips placed in the tumor bed * written informed consent. exclusion criteria: * stage ⅱ-ⅲ * multifocal tumors * histologically confirmed diagnosis of invasive ductal carcinoma (grade 3), invasive micropapillary carcinoma, carcinoma of lobular in situ, invasive lobular carcinoma * paget's disease of the nipple * underwent oncoplastic surgery of ipsilateral breast * underwent neoadjuvant chemotherapy or hormonal therapy * previous or simultaneous contralateral breast cancer * undergone ipsilateral chest wall radiotherapy * active collagen vascular disease.

Keywords: breast conserving surgery accelerate partial breast irradiation intensity-modulated radiation therapy phase ii
hemi-diaphragmatic paresis after erector spinae plane block

Conditions: Regional Anesthesia; Carotid Endarterectomy

Summary: to assess the incidence of hemi-diaphragmatic paresis following ultrasound-guided erector spinae plane (esp) block

the ultrasound (usg) guided esp block was first defined in 2016. with the administration of local anesthesia between the transverse process of the vertebra and the erector spinae muscle, it is stated that the effect mechanism of esp is that spread blocks the ventral and dorsal rami to the paravertebral area. the aim of the study is to assess the incidence of hemi-diaphragmatic paresis following ultrasound-guided erector spinae plane block.

Eligibility criteria:
inclusion criteria: * 18 - 85 years * american society of anesthesiology (asa) i-iii * elective carotid endarterectomy exclusion criteria: * patient's refusal * under 18 years of age or over 65 years of age * asa iv and above * known allergy to local anaesthetic drugs * the block cannot be applied due to bleeding disorders or localized skin infection at the injection site * history of neurological and/or neuromucular disease * history of severe bronchopulmonary disease * a moderate to severe decrease in preoperative pulmonary function, or abnormality in preoperative chest radiography data (pleural effusion, pneumothorax, or hemidiaphragm elevation) * emergency surgery

Keywords: regional anesthesia erector spinae plane block carotid endarterectomy ultrasound guidance
accuracy of pulse oximeters with profound hypoxia

Conditions: Oximetry

Summary: this study to assess the oxygen saturation accuracy of the beddr sleeptuner in profound hypoxia.


Eligibility criteria:
inclusion criteria: 1. the subject is male or female, aged ≥18 and \<50. 2. the subject is in good general health with no evidence of any medical problems. 3. the subject is fluent in both written and spoken english. 4. the subject has provided informed consent and is willing to comply with the study procedures. exclusion criteria: 1. the subject is obese (bmi\>30). 2. the subject has a known history of heart disease, lung disease, kidney or liver disease. 3. diagnosis of asthma, sleep apnea, or use of cpap. 4. subject has diabetes. 5. subject has a clotting disorder. 6. the subject a hemoglobinopathy or history of anemia, per subject report or the first bloodsample, that in the opinion of the investigator, would make them unsuitable for study participation. 7. the subject has any other serious systemic illness. 8. the subject is a current smoker. 9. any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly. 10. the subject has a history of fainting or vasovagal response. 11. the subject has a history of sensitivity to local anesthesia. 12. the subject has a diagnosis of raynaud's disease. 13. the subject has unacceptable collateral circulation based on exam by the investigator (allen's test). 14. the subject is pregnant, lactating or trying to get pregnant. 15. the subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures. 16. the subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.
hush restriction in hiv infected patients

Conditions: HIV Infections

Summary: hiv eradication faces a major obstacle that is viral persistence in latent reservoir cells despite antiretroviral therapy. epigenetic repression plays a central role in viral transgene latency and several epigenetic regulators have been involved in this process. among them, the "human silencing hub" or hush complex, composed of tasor, mpp8 and periphilin, has been shown to recruit the h3k9me3 methyltransferase "set domain bifurcated 1" (setdb1) and is therefore responsible for genes' epigenetic repression. our recent results highlight the ability of vpx from hiv-2/sivsmm to counteract hush and to reactivate latent viruses in a latency model. we propose here to study hush activity along pathogenesis.


Eligibility criteria:
inclusion criteria for group 1: * symptomatic or asymptomatic acute hiv1 infection * age above 15 years old * no arv treatment prior inclusion (excepted as prophylaxis pre or post exposure) inclusion criteria for group 2: * chronic hiv1 infection * age above 18 years old * no arv treatment since at least 3 month (regardless the reason) inclusion criteria for group 3: * hiv2 infection * age above 18 years old * no arv treatment since at least 3 month (regardless the reason) exclusion criteria for all groups: * hiv1 and hiv2 co-infection * evolutive intercurrent pathology, in particular active co-infection (i.e. hbv, hcv, tuberculosis, htlv1) * life-threatening pathology
prevalence of secondary cardiac damage in rheumatic fever patients and penicillin secondary prophylaxis

Conditions: Secondary Cardiac Damage in Rheumatic Fever

Summary: according to american heart association criteria, patients who have had rheumatic fever (rf) should be treated with antibiotic prophylaxis. continuous prophylaxis is recommended in patients with well-documented histories of rf and in those with evidence of rheumatic heart disease. there is a limited data regarding adherence of patients to treatment and efficacy of treatment. in this study, patients with rf who are older than 21 years will be collected from a computerized database of 'maccabi healthcare services', one of the biggest israeli health funds. patients will be assigned to the study after obtaining informed consent. previous adherence to antibiotic prophylaxis will be examined according to computerized database of drugs which were issued to the patient since rf diagnosis. past history of cardiac involvement, including past echocardiograms, will be collected from computerized database. in addition, the current cardiac state will be assessed by an experienced cardiologist, including a full new echocardiogram examination.


Eligibility criteria:
inclusion criteria: - patients older than 21 years who were diagnosed with rf (before age 18 years) according to the computerized database. exclusion criteria: * patients with other rheumatic disease diagnosed before rf diagnosis * patients with other cardiac disease diagnosed before rf diagnosis * patients with neoplastic disease diagnosed before rf diagnosis
duration threstholds of intraoperative hypotension

Conditions: Hypotension

Summary: intraoperative hypotension is common in non cardiac surgery. longer duration of intraoperative hypotension is related with postoperative morbidity and mortality. however, with the change of hypotension criteria, the duration threshold also change. the relationship of different hypotension criteria and its duration is unclear. this study is to explore the their relationship.

intraoperative hypotension is common in non cardiac surgery. longer duration of intraoperative hypotension is related with postoperative morbidity and mortality. however, with the change of hypotension criteria, the duration threshold also change. the relationship of different hypotension criteria and its duration is unclear. this study is to explore the relationship between continous difference mean blood pressure criteria and its duration thresholds for postoperative major adverse events, which include acute cardiac infarction, heart failure, cardiac death, stroke and acute kidney injury.

Eligibility criteria:
inclusion criteria: adults underwent elective non-cardiac surgery exclusion criteria: cardiac surgeries; kidney surgeries; obstetric surgeries; local infiltration anesthesia; surgeries without arterial pressure monitoring; perioperative data missing; patients with more than one operation within a year
depression return to work intervention

Conditions: Job Stress; Distress, Emotional

Summary: this study is a randomized controlled trial to test the effectiveness of a mobile app-based program aimed to help individuals with unemployment-related emotional distress return to work.

this study will compare two different approaches to reducing unemployment-related emotional distress. participants will be involved in the study for a total of 22 weeks. during the first 6 weeks, participants will complete activities relating to either the mobile-app based program or the self-guided job-seeking program. the study team will follow up with participants at 8 weeks after the program is completed and at 16 weeks after the program is completed. participants will also be asked to complete questionnaires before starting the program, during the program, after they complete the program, and at the follow-up visits. the questionnaires will be about the participant's mood, job seeking behavior, and related emotional experiences.

Eligibility criteria:
inclusion criteria: * 18-65 years of age * currently unemployed and actively searching for work * prior to unemployment, were employed full-time (35 hours per week or more) for at least 1 year * prior to unemployment, received an individual highest salary of $100,000 or less * owns an iphone or android phone * willing and able to provide informed consent * has a minimum depression score according to the promis depression scale * able to communicate in english (verbal and written) exclusion criteria: * current moderate or severe alcohol/substance use disorders * current symptoms of mania or psychosis * currently employed, retired, or a full or part-time student

Keywords: depression unemployment
a study of the glucodynamic effects of dulaglutide (ly2189265) in japanese participants with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the glucodynamic effects of dulaglutide in japanese participants with type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * have type 2 diabetes (based on the world health organization \[who\] diagnostic criteria) for at least 1 year. * have diet and exercise therapy only (no oral antihyperglycemic medication for at least 3 months prior to screening). * have a fasting blood glucose value of ≥120 and ≤200 milligrams per deciliter (mg/dl) at screening. * have a screening body weight of ≥50 and ≤80 kilograms. exclusion criteria: * have known allergies to dulaglutide, or other glucagon-like peptide-1 (glp-1) receptor agonists. * have had a clinically significant cardiovascular disease. * have a known clinically significant gastric emptying abnormality or have undergone gastric bypass surgery or restrictive bariatric surgery. * have acute or chronic hepatitis, signs and symptoms of any other liver disease. * have a history of chronic pancreatitis or acute idiopathic pancreatitis, or were diagnosed with any type of acute pancreatitis. * have an estimated glomerular filtration rate (egfr) \<30 milliliters/minute/1.73 meter squared. * in the opinion of the investigator or sponsor, are unsuitable for inclusion in the study.
transnasal humidified rapid-insufflation ventilatory exchange (thrive) could decrease the incidence of oxygen desaturation during suspension laryngoscopy: a randomized controlled trial (optilaryngo)

Conditions: Apnea, Postanesthetic; Desaturation of Blood; Apnea; Anesthesia; Larynx Disease; Pharynx; Anomaly

Summary: suspension laryngoscopy is realised during apnea. in effect, surgeons are in the mouth of the patient and we can't have access at the aiways. so investigators like to use a transnasal humidified rapid-insufflation ventilatory exchange (thrive) to increase time of apnea and decrease the impact of oxygen desaturation.


Eligibility criteria:
inclusion criteria: * suspension laryngoscopy exclusion criteria: * thrive contraindication: * epistaxis * undrained pneumothorax * recent gastroesophageal surgery (1months) * skull fractures

Keywords: time of apnea optiflow thrive apnea oxygenation suspension laryngoscopy general anesthesia oxygenation apnea
effects of breathing exercises in the mothers of children with special health care needs

Conditions: Chronic Low-back Pain

Summary: the aim of the study is to determine the effectiveness of breathing exercises combined with core stabilization exercises in mothers with chronic non-specific low back pain of children with special health care needs.

a total of 46 mothers having children with special health care needs participate in the study. twenty-three mothers in the experimental group receive stabilization exercises with breathing exercises 3 times a week for 8 weeks while 23 mothers in the control group receive only stabilization exercises during the same period of time. each exercise session lasts about 60 minutes and was performed 3 days per week, for 8 weeks. all mothers in both groups perform 15 minutes warm-up stretching exercises prior to the core exercises and 10 minutes cool-down exercises at the end of each session. breathing with the stabilization exercise group receives breathing exercises before the stabilization exercise program. a one-hour theoretical training is given to the mothers about the techniques of diaphragmatic and pursed-lip breathing at the beginning of the study. the pursed-lip breathing is one step further to the diaphragmatic breathing. patients are instructed to do breathing exercises during the stabilization exercises, in which patients focus on their breathing circle, time, and movement while doing the stabilization exercises. all 46 mothers in both groups are given a one-hour training about the stabilization exercises before starting the study. the motor control tests for local muscles transversus abdominus and multifidi are performed after the training. the abdominal bracing test is performed in the quadruped position, in prone, and in hook lying position with the patient's spine supine with hips and knees flexed and knees in contact with the surface. closed-chain segmental control exercises, a series of weight-bearing exercises, and open kinetic chain exercises to promote distal stability are performed.

Eligibility criteria:
inclusion criteria: * primary caregiver of the child * suffering from lbp for at least three months * lumbar instability * absence of radiculopathy or other damages to the spine * not receiving any types of physical therapy during the trial or at least six months prior to the study * enough physical autonomy to participate in the physical activities * be volunteer * be compliant for the study exclusion criteria: * taking any anti-depressant medications and/or having psychotherapy * any surgery within the last 3 months * be pregnant * presence of dysfunction of the musculoskeletal system during the study * participation rate lower than 80% of the program schedule

Keywords: chronic low back pain breathing exercises core stabilization anxiety sleep
endoscopic findings in patients with upper git bleeding

Conditions: GIT - Gastrointestinal Tract Hemorrhage

Summary: this study aims to identify the causes of upper gastrointestinal bleeding through comprehensive evaluation via upper endoscopy in assiut university hospital and contribute valuable insights into effective management strategies.

upper gastrointestinal bleeding (ugib) is a critical medical situation that arises when there is bleeding proximal to the ligament of treitz \[1\]. this condition is a leading cause of morbidity and mortality, with death rates ranging from 5-14% and increasing to over 40% in patients with liver disease\[2\] symptoms of ugib may include anemia, hematemesis, melena, or hematochezia \[3\]. neoplasms, arteriovenous malformations, esophageal varices, gastric ulcers, gastric erosions, duodenal ulcers, reflux esophagitis, mallory-weiss tears, and fundal varices are causes of ugib \[4\]. current strategies for managing ugib emphasize early recognition and intervention. endoscopy is the primary diagnostic and therapeutic modality, allowing for direct visualization of the gastrointestinal tract and enabling interventions such as cauterization, clipping, or band ligation to control bleeding \[5\]. recent advancements in endoscopic techniques have improved outcomes by facilitating earlier detection and treatment of ugib episodes. for instance, the use of hemostatic powders and over-the-scope clips has shown promise in managing refractory cases\[6,7\]. endoscopic therapies may have resulted in earlier detection and treatment of ugib, which could have led to a reduction in the incidence and severity of the condition. upper gi endoscopy is considered the primary modality for identifying the underlying etiology and administering appropriate therapeutic measures to the patient present with upper git bleeding by ligation ,clips, electrocoagulation or by taking biopsies that help in diagnosis. the rationale for this research stems from the need to enhance understanding of ugib's underlying causes and improve patient outcomes through timely endoscopic intervention. by identifying specific etiologies through upper endoscopy\[8,9\].

Eligibility criteria:
inclusion criteria: * adult patients present with upper git bleeding of both gender older than 18 years old exclusion criteria: * 1- patients younger than 18 2- pregnant women 3- patients with end stage disease that not fit for endoscopic intervention
covid-19 convalescent plasma and monoclonal antibodies treatment of immunocompromised patients

Conditions: COVID-19 Convalescent Plasma Treatment

Summary: data on the use of convalescent plasma in the treatment of covid-19 are scarce: the results of randomized studies involving mainly immunocompetent patients are disappointing, while case series or retrospective data on more selected patients , in particular immunocompromised patients suggest a benefit in these patients whose clinical manifestation seems essentially related to the uncontrolled infection and not the cytokine storm.


Eligibility criteria:
inclusion criteria: * adult patient * immunocompromised patient (solid neoplasia, malignant hemopathy, solid organ transplantation, primary immune deficiency, systemic disease, chronic inflammatory disease, etc.) * hospitalized between 25/02/2020 and 15/01/2023 at hus, icans, ch colmar and ch mulhouse * having received curative monoclonal antibody treatment or convalescent plasma treatment for sars-cov2 infection * patient who has not expressed, after being informed, his opposition to the reuse of his data for scientific research purposes. exclusion criteria: * subject who expressed their opposition to participating in the study * subject under guardianship, curatorship or safeguard of justice

Keywords: covid-19 sars-cov2 immunosuppression cytokine convalescent plasma monoclonal antibodies
a performance study of (opportunistic) salpingectomy

Conditions: Adnexal Lesion; Ovarian Cancer

Summary: the goal of this clinical trial is to test the quality of the performance of opportunistic salpingectomies in women scheduled for adnexectomy. the main questions it aims to answer are: * how many salpingectomies are incomplete? * are there any factors related to incomplete resection? could the investigators develop a instruction video to optimize the surgical technique? participants planned for uni-or bilateral adnexectomy (removal of ovary and salpinx) will have their adnexectomy in two steps in the same surgical episode: first the salpingectomy (removal of the salpinx), then the oophorectomy (the removal of the ovary).

rationale: salpingectomy in post-reproductive women could reduce the risk of developing ovarian cancer. in women at high risk for ovarian cancer (because of genetic mutations) a risk reducing salpingectomy with delayed ovariectomy could be an advantage. it is considered that salpingectomy does not cause premature menopausal symptoms. prospective randomized trials are being performed to estimate the true risk reducing effect of salpingectomy on ovarian cancer. those studies are based on a complete bilateral salpingectomy. objective: the qos study investigates the quality of performance of opportunistic salpingectomy and the risk factors associated with reminiscing fimbrial tissue after salpingectomy. study design: multicenter interventional trial study population: patients planned for unilateral or bilateral adnexectomy (removal of ovary and salpinx) will be counselled to participate. intervention: the gynecologist will perform the adnexectomy in two steps in the same surgical episode: first the salpingectomy (removal of the salpinx), then the oophorectomy (the removal of the ovary). the pathologist investigates for pathology and describes if fimbrial tissue (the last part of the salpinx adjacent to the ovary) has been left behind on the ovarian surface microscopically and macroscopically. main study parameters/endpoints: the primary outcome is the percentage of incomplete salpingectomies. secondary outcome is the detection of factors related to incomplete resection of the salpinx. if necessary a guideline/instruction video could be developed to optimize the surgical technique. a total of 200 specimens are to be included to answer the primary endpoint.

Eligibility criteria:
inclusion criteria: patients scheduled for uni- or bilateral adnexectomy. (may be in combination with hysterectomy) and \* competent to act on itself * dutch speaking * signed informed consent exclusion criteria: \* endometrial cancer or invasive cervical cancer * radiotherapy in the pelvis in the medical history * (partial) salpingectomy * pelvic inflammatory disease * adnexectomy for gender transformation surgery if wish to preserve the ovarian tissue. * surgery in two steps is not safe to perform * pregnancy

Keywords: salpingectomy