Kornimate/medical-research-clean huggingface dataset:
glaucoma biomarkers

Conditions: Glaucoma; Healthy

Summary: glaucoma is a major cause of blindness. the inability to predict a patient's iop response to medications is a critical barrier for the clinician to consistently provide highly effective iop-based treatments. current trial-and error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large iop fluctuation. our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict iop response to drugs.


Eligibility criteria:
inclusion criteria: * either gender. * any self-declared ethnoracial category. * greater than or equal to 40 years. * healthy eyes with the crystalline lens, without glaucoma (cup:disc ratio \< 0.8 both eyes; asymmetry of cup:disc ratio between eyes \< 0.2). * open angles. * ability to cooperate for aqueous humor dynamic studies. * nonprescription and prescription topical ophthalmic products and systemic medications other than those mentioned in the exclusion criteria will be allowed during the study. * contact lenses removed prior to topical fluorescein instillation, and not used until the end of each fluorophotometry session. * able to participate on site over the multi-visit study period. exclusion criteria: * women who are pregnant due to iop changes. * any form of glaucoma, including extremely narrow angle with complete or partial closure. * current use of any glaucoma medication, either topically or orally. * chronic or recurrent inflammatory eye disease. * ocular trauma within the past 6 months. * ocular infection or ocular inflammation in the past 3 months. * clinically significant retinal disease. * any abnormality preventing reliable fluorophotometry of either eye, such as corneal scarring or severe dry eye that results in punctate fluorescein staining of the cornea. * intraocular surgery within 6 months. * serious hypersensitivity to any components of the study medications or risk from treatment with glaucoma medications, such as severe asthma or emphysema. * subjects must be on a stable regimen for at least 30 days prior to the visit 1 regarding a chronic systemic medication that may affect iop (i.e., sympathomimetic agents, beta-blockers, alpha-adrenergic agonists, alpha-adrenergic blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, etc.). any change of such medication during the study period will result in exclusion. * use of any glucocorticoid by any route. subject must be washed out of the glucocorticoid for at least 2 weeks before study entry.

Keywords: glaucoma aqueous humor dynamics intraocular pressure
effect of auricular stimulation on locomotion in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: the effect of auricular stimulation on the locomotion capability in patients with parkinson's disease was investigated.

effect of the auricular stimulation as a supplementary and alternative usage to levodopa was investigated in this study. clinical data were collected through motion capture system while the participants performed the clinical task asked by the investigators.

Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease * h\&y stage \>= 1 * existing bradykinesia symptoms * existence of one of the symptoms below * resting tremor * rigidity * walking disorder exclusion criteria: * cardiac pacemaker * psychiatric diagnosis * irregular heart/respiration rate * pregnancy * alcohol consumption * cardiovascular disease history * wearing an electro-active prosthesis * brain surgery history * ongoing tens/pens therapy

Keywords: neurostimulator
pregnancy outcomes in infertile patients after treatment with ulipristal acetate.

Conditions: Myoma;Uterus; Infertility, Female

Summary: the investigators analyzed a group of infertile women treated with ulipristal acetate (ua) for uterine fibroids at the humanitas fertility center. all the patients' data were extracted from the fertility center external-audit-anonymized electronic research query system.

in the recent years several large studies have been published on the efficacy of ulipristal acetate treatment of moderate to severe symptoms of uterine fibroids in adult women: initially proposed only as pre-surgical treatment, the ua was subsequently also used for the long-term treatment of uterine myomas symptoms. however, few data are available on the effects of ua in terms of increasing fecundability, implantation and pregnancy outcome and safety in the general population, and in infertile patients in particular. this retrospective study aims at describing the correlation between the use of ulipristal acetate and pregnancy outcome in infertile patients and at comparing the ua plus surgery approach to the ua-only treatment in terms of pregnancy outcome.

Eligibility criteria:
inclusion criteria: * infertile women received at least 1 month of therapy with ua 5 mg/day for uterine fibroids * more of 1 year of active pregnancy seeking exclusion: * menopausal women;
thromboembolic complications in covid-19 patients in intensive care unit

Conditions: COVID-19-Associated Thromboembolism

Summary: the present study aims to determine frequency of thromboembolic complications and the underlying causes of this complication of the patients who admitted to the intensive care unit diagnosed with covid-19.

patients diagnosed with covid-19 infection and admitted to the icu were recruited. demographic information, comorbidities, length of icu stay, some laboratory data,thromboembolic complications of the patients were recorded.

Eligibility criteria:
inclusion criteria: * patients who were infected with covid-19 and admitted to the intensive care unit between the time of march 2020-december 2021 exclusion criteria: * who is under 18 years old.

Keywords: covid-19 thromboembolism variants of covid-19
long-term study of syr-472

Conditions: Diabetes Mellitus

Summary: to evaluate the safety and efficacy of long-term treatment with syr-472 in diabetic patients.


Eligibility criteria:
inclusion criteria: 1. the participant is an outpatient. 2. the participant signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures. 3. diabetes mellitus exclusion criteria: 1. the participant has any serious cardiac disease, serious cerebrovascular disorder, or any serious pancreatic or hematological disease. 2. the participant is considered ineligible for the study for any other reason by the investigator or subinvestigator.
anti-flt3 car t-cell therapy in flt3 positive relapsed/refractory acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: this is a prospective,open-label, phase1/2 study to evaluate the safety and efficacy of anti-flt3 chimeric antigen receptor engineered t cell immunotherapy (cart) in the treatment of flt3 positive relapsed or refractory acute myeloid leukemia.

the patients will receive infusion of anti-flt3 car t-cells targeting flt3 to evaluate the safety and efficacy of anti-flt3 car t-cells in relapsed or refractory acute myeloid leukemia.

Eligibility criteria:
inclusion criteria: * flt3 positive relapsed/refractory acute myeloid leukemia * age 16-65 years. * left ventricular ejection fractions ≥ 0.5 by echocardiography * creatinine \< 1.5x upper limit of normal. * aspartate aminotransferase/aspartate aminotransferase ≤ 2.5x upper limit of normal * total bilirubin ≤ 1.5x upper limit of normal * karnofsky performance status ≥ 60 * expected survival time ≥ 3 months (according to investigator's judgement) exclusion criteria: * patients are pregnant or lactating * uncontrolled active infection * grade iii/iv cardiovascular disability according to the new york heart * association classification * active hepatitis b or hepatitis c infection * patients with hiv infection * patients with a history of seizure * patients with other contraindications considered unsuitable for participation in this study (according to investigator's judgement)

Keywords: flt3,car-t,aml
golf instruction versus tai chi for people with parkinson's disease

Conditions: Parkinson Disease; Movement Disorders; Neuro-Degenerative Disease

Summary: the purpose of this study is to determine the feasibility and tolerability of golf instruction for participants with moderate to advanced parkinson's disease (pd). other forms of exercise have been shown to be beneficial for pd. golf is a low impact sport that utilizes balance and strength. currently, there are no data looking at the effects of golf on pd. this pilot study aims to test the effects of golf in the pd patient population, particularly its effect on balance. in this study, we will be comparing group golf instruction to group tai chi lessons (the gold standard balance exercise for patients with pd).

approximately, 40-50 participants with parkinson's disease (h\&y stage 2 to 3) will be enrolled in this study. participants who provide informed consent will be randomized 1:1 to either group golf instruction or group tai chi classes. participants will be evaluated before and after the intervention with a battery of cognitive, motor and balance assessments including the updrs, the mini-bestest of balance, and timed up and go tests. they will participate in classes twice weekly for 10 weeks which will be provided free of charge. at the end of the intervention period they will repeat the assessments. the primary outcomes of the study are feasibility and tolerability. the key secondary objectives are to measure the efficacy of golf instruction on measures of balance, risk of falls.

Eligibility criteria:
inclusion criteria: * adult participants with a diagnosis of parkinson's disease by a movement disorders specialist, h\&y stage ii-iii in the "on" state treated with parkinson's disease medications * participants must be capable of providing informed consent and complying with trial procedures including transportation to and from classes. * participants must be willing and able to participate in group exercise classes. * participants who are engaged in physical therapy or other exercise programs must be at a stable regimen for 60 days prior to the start of the study and must be willing to maintain their current regimen for the duration of the study. exclusion criteria: * clinical evidence of unstable medical or psychiatric illness which would prevent them from engaging in exercise * participants who are already active golfers or currently active in tai chi would be excluded.
effect of caffeine versus probiotic on preterm neonates with bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia

Summary: the aim of this study is to evaluate the effectiveness of caffeine versus probiotics supplementation as adjuvant therapy for preterm neonates with bronchopulmonary dysplasia (bpd).


Eligibility criteria:
inclusion criteria: * male and female preterm neonates less than 37 weeks gestational age. * suffering from bronchopulmonary dysplasia (bpd) diagnosed as follow: * history: preterm infant with persistence oxygen dependency up to 28 days of life. * clinical signs: increase work of breathing, increase oxygen requirements , increase in apnea , bradycardia and retraction. * laboratory: arterial blood gases and electrolytes. * radiology: streaky interstitial markings, patchy atelectasis , intermingled with cystic areas and severe lung hyperinflation. exclusion criteria: * term and post term neonates * neonates with congenital infections * neonates with major congenital anomalies
a telemedicine brief mindfulness intervention in post-covid-19

Conditions: Post COVID-19

Summary: background: several studies suggest that sars survivors still presented with high levels of psychological distress overall at 1, 3, 12, and 18 months after hospital discharge. nonetheless, there are no data available in the literature regarding the implementation of interventions that are psychological interventions, let alone specific ones. in particular, the practice of mindfulness, formalized in the protocols such as mindfulness based stress reduction (mbsr) and mindfulness based cognitive therapy (mbct). based cognitive therapy (mbct), have proved to be very effective in reducing stress related to chronic conditions and of depression. however, these protocols typically require a high level of engagement for participants, which is why, in the present exploratory study, the investigators opted to evaluate the implementation of a mindfulness-based protocol that is short and less intense, but which has shown good results on health-related outcomes, even with a single session. objectives: in this perspective, it becomes important to detect the presence of psychological distress in those who have contracted covid-19 and are now undertaking a rehabilitation program, from the perspective of promoting well-being and prevention of possible aggravation if not prolongation of mental suffering in the long term. study design: randomized and controlled (rct), two-arm pilot study with three data captures (baseline=t0, 3 weeks=t1, 3 months=t2). participants: people who have previously tested positive for covid-19, now negative and hospitalized at the irccs santa maria nascente of the fondazione don carlo gnocchi in milan.


Eligibility criteria:
inclusion criteria: * previously positive for covid-19 and now negative and undergoing treatment pulmonary rehabilitation; * compatibility to participate in the study as judged by the physician; * able to provide informed consent. exclusion criteria: * the physician's unfavorable opinion of inclusion in the study because he or she is unable to provide informed consent; * patients with lung cancer; * documented psychiatric disorders; * immunodepression; * patients with terminal or neurodegenerative diseases (e.g., other forms of cancer, amyotrophic lateral sclerosis (als)).

Keywords: post covid-19 mindfulness randomized controlled trial post traumatic stress disorder
exendin pet/ct for imaging of paragangliomas

Conditions: Paraganglioma

Summary: functional imaging of paragangliomas (pgls) is not unequivocal. existing functional imaging modalities show good but variable results in pgls, warranting the search for additional molecular imaging targets. investigators aim to evaluate the glucagon-like peptide 1 receptor (glp-1r) as a novel target for molecular imaging of pgls. for this purpose investigators will use the tracer 68ga-nodaga-exendin 4 for positron emission tomography/computed tomography (pet/ct) imaging.

rationale: functional imaging of paragangliomas (pgls) is not unequivocal. existing functional imaging modalities show good but variable results in pgls, warranting the search for additional molecular imaging targets. investigators aim to evaluate the glucagon-like peptide 1 receptor (glp-1r) as a novel target for molecular imaging of pgls. for this purpose investigators will use the tracer 68ga-nodaga-exendin 4 for positron emission tomography/computed tomography (pet/ct) imaging. objective: the primary objective is to examine the feasibility of 68ga-exendin-4 pet/ct for localization and functional characterization of pgls. study design: in this prospective pilot imaging study 68ga-exendin-4 pet/ct will be performed in 10 patients with confirmed pgl who have undergone ct, somatostatin receptor (sstr) pet/ct and 18f-fdg pet/ct (as standard diagnostic procedures) and are scheduled for surgery. 100 ± 10 mbq 68ga-nodaga-exendin-4 will be administered to 10 patients in total. in the first 5 patients pet/ct imaging will be performed 1, 2 and 4 hours after injection to determine the optimal imaging timepoint for the remainder of the patients, which will be applied in the remaining patients. the images will be reconstructed and evaluated by a nuclear medicine physician who is blinded to the results of the ct, sstr pet/ct and 18f-fdg pet/ct to assess tumor detection. additionally, quantitative analysis of 68ga-exendin-4, sstr pet and 18f-fdg pet/ct images will be performed. after the patients have undergone surgery, immunohistochemical analysis of surgical specimens will be performed to assess glp-1r expression, which will be compared with in vivo tracer uptake.

Eligibility criteria:
inclusion criteria: * proven sympathetic pgl with a single tumor detected using standard diagnostic imaging * no evidence of metastatic disease * ct, sstr pet/ct and 18f-fdg pet/ct performed (golden standard diagnostic imaging) * scheduled for surgery * able to sign informed consent exclusion criteria: * breast feeding * pregnancy or the wish to become pregnant within 1 month * calculated creatinine clearance below 40ml/min * evidence of other malignancy than pgl in conventional imaging (suspicious liver, bone and lung lesions) * age \< 18 years * not able to sign informed consent
unilateral blindness/ unilateral deafness-relation to neck pain

Conditions: Neck Pain; Unilateral Blindness; Unilateral Deafness

Summary: neck pain is a common complaint in the general population affecting 10-15% of the general population. females more than men. known risk factors are: trauma, repetitive lifting of heavy objects at work, driving vibrating vehicles, frequents diving from boards and smoking. no study dealt with the possible role of unilateral loss of vision or hearing as a risk factor for the development of neck pain. intuitively, one might suspect that unilateral blindness or deafness will lead to a tilted position of the head, in order to cover a better visual/audio field. this position, in time, might lead to the development of neck pain. our hypothesis is that patients with unilateral blindness/deafness will suffer from neck pain more frequently than the general population.


Eligibility criteria:
inclusion criteria: * men and women suffering from unilateral blindness or deafness * men and women visiting the ophthalmology or ent clinics (general population) for reasons other than unilateral blindness/deafness and agreeing to participate in the study. * over 18 years of age * signed informed consent exclusion criteria: * subjects suffering from neck pain as a result of fractures, infection, or metastatic disease. * inability to understand or fill out the questionnaire/informed consent.
can remote photoplethysmography be used for contactless vital sign acquisition in a healthcare setting? a prospective comparative study.

Conditions: Coronavirus; Cardiac Disease; Respiratory Disease; Vascular Diseases

Summary: contactless and widely available health monitoring technologies are of growing interest in the context of the worldwide covid-19 pandemic. remote photoplethysmography (rppg) is a well-studied technology that interprets variations in skin colour related to blood flow which, when analysed with complex mathematical algorithm, generates vital sign readings. this technology has been refined and embedded in a smartphone app designed to acquire heart rate, respiratory rate and oxygen saturation using a front-facing smartphone camera. preliminary data comparing the accuracy of smartphone rppg readings with conventional vital sign monitor readings are promising; however, less than 5% of the population studied in the app development phase had oxygen saturation levels below 95% making it impossible to ensure reliability in these populations. the goal of this study is to compare readings acquired using this rppg app with the readings from hospital grade, health canada approved vital signs monitors used in healthcare settings with a focus on subject with low oxygen saturations. we will also study other sociodemographic and clinical features that may influence the accuracy of the readings. this will be achieved by recruiting consenting adults presenting to care in acute care settings and a designated covid outpatient clinic. vital signs will be acquired using the rppg app and conventional hospital vital sign monitors simultaneously. readings will be repeated within 2-5 minutes when time permits. statistical analysis will be performed to analyze the findings and determine the accuracy and precision of the rppg app readings. it is expected that the vital sign readings acquired with the rppg app will be almost identical to those acquired using hospital-grade monitors for all subjects regardless of age, gender, skin colour, covid status and relevant comorbidities.


Eligibility criteria:
inclusion criteria: * persons willing to participate and capable of providing informed consent, age of 18 years of more. * person able to sit still for the duration of the reading (maximum 2 minutes per reading). * persons with freckles, discreet skin pigmentation changes exclusion criteria: * unable to provide informed consent * persons who are unable to follow basic instructions due to altered mental status, delirium, dementia or other conditions. * age \< 18 * intubated patients and patients requiring masks for supplemental oxygen * persons refusing to remove masks, eyewear, or clothing obstructing the face for the duration of readings. * persons with facial tattoos, large birthmarks or other skin alterations (scars, hemangiomas) on their nose or upper cheeks (cheekbones).

Keywords: oximetry pulse oximetry respiratory rate remote photoplethysmography coronavirus