Kornimate/medical-research-clean huggingface dataset:
curcumin as a novel treatment to improve cognitive dysfunction in schizophrenia

Conditions: Schizophrenia; Cognition; Psychosis

Summary: the investigators propose to test whether curcumin nanoparticles will improve behavioral measures and biomarkers of cognition and neuroplasticity in patients with schizophrenia who are already receiving a stable dose of antipsychotic.

the investigators will use a formulation of curcumin with high bioavailability that possesses a pharmacokinetic profile expected to exert biological effects. specifically, 36 subjects will be enrolled in the double-blind randomized controlled trial. they will be randomized to curcumin or placebo for 8 weeks. at baseline, and 4 and 8 weeks, subjects will receive assessments of neurocognition (e.g., processing speed, attention and vigilance, working memory, learning, reasoning and problem solving), social cognition, eeg biomarkers (e.g., visual cortical plasticity and mismatch negativity), a serum marker of neurogenesis (bdnf levels), and clinical symptoms (positive and negative symptoms). at weeks 2 and 6 subjects will return for additional safety (e.g., vitals, side effects, akathisia) and medication adherence assessments. improvement on the primary outcome measure (matrics consensus cognitive battery), as well as secondary outcome measures, will be compared between participants randomized to placebo versus curcumin. the results of this study will establish whether curcumin is a viable adjunctive agent for future larger clinical trials.

Eligibility criteria:
inclusion criteria: * dsm-5 diagnosis of schizophrenia * age 18 - 65 years * understand spoken english sufficiently to comprehend testing procedures * corrected vision of at least 20/30 * currently prescribed an antipsychotic medication exclusion criteria: * clinically significant neurological disease determined by medical history (e.g., epilepsy) * history of serious head injury (i.e., loss of consciousness \> 1 hr., no neuropsychological sequelae, no cognitive rehabilitation post head injury) * sedatives or benzodiazepines within 12 hrs of testing * any psychiatric hospitalization within 3 months prior to study participation * behaviors suggesting any potential danger to self or others within 6 months prior to study participation * antipsychotic dose change more than 50% over the 3 months prior to study participation * acute medical problems or untreated chronic medical conditions within 3 months prior to study participation

Keywords: curcumin turmeric schizophrenia cognition psychosis
drug-drug interaction study of vch-222 and telaprevir in healthy subjects

Conditions: Hepatitis C

Summary: the purpose of this study is to investigate the pharmacokinetics, safety, and tolerability of the co-administration of vch-222 and telaprevir in healthy subjects.


Eligibility criteria:
inclusion criteria: * healthy males, and/or healthy females of non-childbearing potential, aged 18 to 55 years (inclusive) * body mass index (bmi) between 18 and 31 kg/m2 (inclusive) and weight \> 50 kg exclusion criteria: * women of child bearing potential * subjects positive for hepatitis b, hepatitis c, or hiv * subjects who have participated in a clinical study involving administration of an investigational drug within 2 months

Keywords: vx-950 vx-222 stat-c
anticoagulation in cancer related stroke

Conditions: Cancer; Stroke

Summary: purpose: cancer associated intravascular coagulopathy is the primary mechanism of cancer-related stroke, particularly in those without conventional stroke etiologies. randomized clinical trials have investigated efficacy of vitamin k-dependent oral anticoagulant (warfarin), low-molecular-weight heparin (lmwh) and non-vitamin k-dependent oral anticoagulant (noac) for the prevention of systematic venous thromboembolism. however, relatively little is known about the biological changes underlying intravascular coagulopathy and mechanisms of anticoagulation therapy in patients with cancer-related stroke. the aim of this study is to evaluate to determine the biological markers for intravascular coagulopathy causing stroke and for monitoring the effects of anticoagulation therapy, in patients with active cancer and stroke.


Eligibility criteria:
inclusion criteria: * age 20 years and older * acute ischemic stroke presented within 7 days of symptom onset * cancer related stroke: active cancer (diagnosis of cancer within 6 months of stroke onset, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer) and ischemic stroke which could not be explained by conventional stroke mechanisms including large artery atherosclerosis, cardioembolism, lacunar infarction, or other etiologies (e.g., dissection) * signed informed consent or appropriate signed deferral of consent where approved exclusion criteria: * primary intracranial malignancy * incomplete workup for stroke etiology (either vascular or cardiologic studies) * any signs of infectious or immunological diseases which may influence plasma d-dimer levels * patients with stroke suspected to be caused by the tumor itself (i.e., tumor emboli) or cancer treatment (i.e., chemotherapy-induced stroke)
attachment style and mentalization impact among women victims of domestic violence

Conditions: Violence, Domestic

Summary: attachment and mentalization with a population of domestic violence victims domestic violence is one of the most common forms of domestic violence. multiform and complex, it affects all backgrounds and all ages. according to a survey instituted by the government of emmanuel macron, 219,000 women were recognized as victims of domestic violence in 2017. this phenomenon is not without questioning the scientific scene. also, this study focus on the quality of the attachment because if this bond is insecure, it can constitute a point of vulnerability in self-construction and impact on future relational modalities.

the security of the bond of attachment depends on the capacity of the maternal figure, or her substitute, to understand and respond in an adapted and consistent manner to her baby. in addition, it has also been established that when disruptions occur in the security of attachment bond, the quality of mentalization is impacted. but, mentalization is the quality and quantity of psychic representations available to allow someone understanding and thinking about his links to others and to himself. this is an essential asset in the release of situations of violence and in overcoming trauma because it participates in psychic development. that's why this research focuses on early relationships and the quality of mentalization with a cohort of thirty women victims of domestic violence, consultant within the legal medicine department of the chu of besançon. this research focuses on two groups of subjects: women who managed to get out of violent relationship (15 subjects) and others who did not (15 subjects). the research methodology includes several tools: two projective tests (rorschach and tat), ten self-questionnaires (which assess attachment, stress, social support, relational quality with the main attachment figures, the image of the self-body, quality of mentalization), a clinical research interview and presentation of the aai. the observation of this population will highlight the impact of the early environment in the psychic construction of the subject and the victim's destiny. moreover, this study will look at the role of psychotherapeutic follow-up in the quality of mentalization.

Eligibility criteria:
inclusion criteria: * women over 20 years old, victims of domestic violence * with european culture * separated from their abusive partner * consulting the legal medicine department in besançon university hospital exclusion criteria: * refusal to participate

Keywords: domestic violence attachment mentalization victimization psychic elaboration of the trauma
physiologic effects of high flow nasal therapy in patients with acute hypoxemic respiratory failure (optiflow)

Conditions: Respiratory Failure

Summary: the aim of the study is to assess, in patients with acute hypoxemic respiratory failure, the short term physiologic effects of the high flow oxygen nasal therapy (optiflow), in term of inspiratory muscle effort, gas exchange, comfort and dyspnea

the administration of a known concentration of oxygen is an important part of routine care of the patient admitted in intensive care unit for acute hypoxemic respiratory failure. a new high flow oxygen delivery system (fisher and paykel health care) has been developed (optiflow). the system used a heated humidifier and heated breathing circuit via a nasal interface. high flow nasal therapy (optiflow) is associated with the generation of significant positive airway pressure in healthy volunteers. positive expiratory pressure may have a number of benefits in respiratory failure which include improved ventilation/perfusion matching with improved oxygenation, reduced airways resistance and reduced work of breathing. moreover high flow nasal therapy may improve oxygen administration by decreasing oxygen dilution, decreasing death space and using high levels of humidification

Eligibility criteria:
inclusion criteria: * acute respiratory insufficiency, defined as the pao2/fio2 ratio of 300 mm hg or less after breathing oxygen * the presence of lung infiltrates on a posteroanterior chest radiograph exclusion criteria: * face or cranial trauma or surgery * patients younger than 18 years * history of copd * acute respiratory acidosis (defined as a ph \ 50 mm hg) * hemodynamic instability with arterial pressure \< 90mmhg * respiratory instability with pao2/fio2\<100mmhg * ventricular arrhythmias * excess respiratory secretions. * upper gastrointestinal bleeding * recent gastric or oesophageal surgery * tracheostomy or other airways disorders * pneumothorax * contraindication of gastric probe insertion * impossibility to insert the oesophageal probe
using plain water with oral care to increase hydration for long term care residents with disordered swallowing

Conditions: Dysphagia; Respiratory Tract Infections

Summary: the frazier free water protocol (ffwp) using plain, thin (unmodified) water is an accepted method to increase fluid intake and hydration in older adults with disordered swallowing and dementia.this study aims to take an interdisciplinary approach to see if the ffwp with improved oral care can be introduced in a long term care (ltc) setting comparing an intervention group with a control group receiving standard oral care, to prevent respiratory infections.

the investigators will recruit a convenience sample of 36 participants from a single long-term care facility. participants will be randomly assigned into control or intervention groups. both groups will be assessed at study onset for swallowing and oral health and continue with agreed upon diet texture and fluid modifications. the intervention group (ffwp and improved oral hygiene) will receive a dental hygienist cleaning at onset of the study and have supervised tooth brushing before thin water between meals. the control group will continue with standard oral care and offered the full dental hygienist cleaning at the end of the study. if findings indicate no difference between groups on outcome measures (eg. respiratory illness, hydration, nutrition) then the intervention is considered efficacious in long-term care residents. if improvements in outcome measures are evident for the treatment relative to the control group, then this intervention may provide opportunity for improved healthcare and cost-savings.

Eligibility criteria:
inclusion criteria: * long term care residents with moderate to severe swallowing difficulty and modified texture diet; or have a dry mouth and thirsty most of the time by report of patient participant, family or staff. exclusion criteria: * participant resident taking part in another study; participant finished another study in last 30 days prior to this study; participant has dental pain or waiting to see a dentist for pain and discomfort; participant has current chest infection including pneumonia or is prone to chest infections with more than one episode per year; participant is unable to tolerate assessments and oral care.

Keywords: aspiration pneumonia dementia dysphagia oral hygiene long-term care frazier free water
comparison of pre-operative measurements with intraoperative aberrometry in predicting correction for low toric lens correction in cataract surgery

Conditions: Cataract Surgery

Summary: examination of the accuracy of toric predictive power in patients with 1.5 diopters of astigmatism or less.

based on preoperative keratometry and using the baylor nomogram and a standard factor for surgically-induced astigmatism, the investigators will calculate "keratometry-based total astigmatism" for each patient. this will be compared to "aberrometry-based total astigmatism", i.e. the total astigmatism measured by ora in each case. with this information the investigators will determine in what portion of patients keratometry-based total astigmatism vs aberrometry-based total astigmatism predicts a need for astigmatism correction, (i.e., total astigmatism is greater than or equal to 0.5 d) during cataract surgery.

Eligibility criteria:
inclusion criteria: * patients who underwent conventional (non-femtosecond) cataract surgery and whose "data to be collected" are accessible and available from the ora database. * patients whose medical records show they did not exhibit any significant ocular morbidity that would be expected to influence outcome measures. exclusion criteria: * patients with visually significant co-morbidities (corneal, retina, optic nerve disease) that could affect their visual outcome or ability to be refracted after. * patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered iol, cystoid macular edema, etc.) * patients with previous refractive surgery.
investigation of the gut microbiota in acute myeloid leukemia receiving two different induction therapies

Conditions: Acute Myeloid Leukemia; Adult; Gut Microbiota; Infections

Summary: in this observational single-center cohort study, metagenomic next-generation sequencing (mngs) will be used to investigate the features and changes of gut microbiota in acute myeloid leukemia (aml) patients during the treatment of two different induction therapy regimens \[standard intensive chemotherapy (7+3) or bcl-2 inhibitor-based targeted therapy\].

infections remain one of the major complications during induction therapy of acute myelocytic leukemia (aml). previous studies have shown that the variation of gut microbiota was an effective predictor for infection development of aml during induction therapy. a growing number of patients with aml received bcl-2 inhibitor-based targeted induction therapy. the investigators assume that there are different effects of bcl-2 inhibitor-based induction therapy on gut microbiota compared with standard intensive chemotherapy (7+3 regimen). metagenomic next-generation sequencing (mngs) will be used to perform the investigation of gut microbiota in aml receiving two different induction therapies. and the relationships of gut microbiota with infection complication will be analyzed.

Eligibility criteria:
inclusion criteria: 1. male or female, 65\> =age (years) \>= 18; 2. newly diagnosed as aml patients according to world health organization (who) classification; 3. eastern cooperative oncology group (ecog) performance status of 0,1,2; 4. patients will receive standard intensive chemotherapy (7+3) or bcl-2 inhibitor-based targeted therapy; 5. patients have not received prior therapy for aml (except hydroxycarbamide); 6. liver function: total bilirubin lower than 3 upper limit of normal (uln); aspartate aminotransferase (ast) lower than 3 uln; alanine aminotransferase (alt) lower than 3 uln (except extramedullary infiltration of leukemia); 7. renal function with creatinine clearance rate (ccr) higher than 30 ml/min; 8. patients who sign the informed consent must have the ability to understand and be willing to participate in the study and sign the informed consent. exclusion criteria: 1. acute promyeloid leukemia; 2. aml with central nervous system (cns) infiltration; 3. any history of chronic intestinal affections (crohn disease, inflammatory bowel disease, gluten intolerance) or gastrointestinal surgery; 4. hiv infection, chronic hepatitis b virus (hbv) or hepatitis c (hcv) requiring treatment; 5. severe and active infection that is difficult to control and cannot tolerate induction therapy; 6. female who are pregnant, breast feeding or childbearing potential without a negative urine pregnancy test at screen; 7. antibiotic exposure within 30 days before enrollment (carbapenems and/or tigecycline were not included, penicillin, cephalosporins and quinolones could be included) 8. patients reject to participate in the study; 9. patients with severe heart failure (grade 3-4) or patients deemed unsuitable for enrolment by the investigator.
ampicillin/sulbactam versus cefuroxime as antimicrobial prophylaxis for cesarean section

Conditions: Surgical Site Infections

Summary: the efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been assessed. women scheduled for cesarean delivery were randomized to receive a single dose of either 3g of ampicillin-sulbactam or 1.5g of cefuroxime intravenously, after umbilical cord clamping. an evaluation for development of postoperative infections and risk factor analysis was performed.

the efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been assessed. the investigation was designed to evaluate the efficacy and safety of a single dose of ampicillin/sulbactam 3g compared to a single dose of cefuroxime 1.5g in preventing postoperative morbidity. the primary outcome was development of an infection either at the surgical site or elsewhere e.g. urinary tract infection. a prospective randomized controlled study was performed from july 2004 to december 2008 in one major tertiary care hospital in athens greece. all patients undergoing a cesarean delivery were eligible.patients were randomly assigned to receive either 1.5g of cefuroxime, or 3g of ampicillin/ sulbactam intravenously after the time the umbilical cord was clamped.

Eligibility criteria:
inclusion criteria: - all patients undergoing a cesarean delivery were eligible. exclusion criteria: * patients with known hypersensitivity to penicillin or cephalosporins. * patients who required concomitant antibiotic therapy during surgery. * patients who have received antibiotics during the 72 hours immediately preceding their enrollment. * patients whose postpartum fever was clearly associated with other known causes.

Keywords: post-cesarean infections ampicillin-sulbactam cefuroxime cesarean
feasibility and acceptability of primary palliative care intervention in patients undergoing hematopoietic stem cell transplantation

Conditions: Hematopoietic Cell Transplant; Hematologic Malignancy

Summary: primary pc - or training hct clinicians to deliver pc domains as part of routine practice - is an alternative model of supportive care. we have developed sentinel, a primary pc intervention for hct clinicians and patients. this study will assess sentinel's feasibility and acceptability.

patients hospitalized for hematopoietic cell transplantation (hct) experience physical and psychological symptoms that lead to a deterioration in quality of life (qol). integrating specialty palliative care (pc) reduces physical and psychological symptom burden and improves qol during hct hospitalization. however, specialty pc remains unavailable and underused at many hct centers. primary pc - or training hct clinicians to deliver pc domains as part of routine practice - is an alternative model of supportive care. we have developed sentinel, a primary pc intervention for hct clinicians and patients. we will train hct clinicians to deliver pc to patients before and during hct hospitalization. this study will assess sentinel's feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * age 18 years or older * undergoing autologous or allogeneic hct at mgh exclusion criteria: * prior receipt of inpatient specialty palliative care on two prior admissions in the past 6 months. * significant uncontrolled psychiatric disorders (psychotic disorder, bipolar disorder, major depression) or other co-morbid disease (dementia, cognitive impairment), which the primary oncologist believes prohibits informed consent or ability to participate in study procedures * inability to comprehend english as this is a preliminary/pilot study

Keywords: palliative care supportive care primary palliative care hematopoietic cell transplantation
evaluation of clinical-functional and radiographic outcomes in patients who underwent meniscal allograft transplantation (mat) at 15 years.

Conditions: Meniscus Disorder; Arthritis Knee

Summary: menisci are crescent-shaped cartilage structures that are fundamentally important for the biomechanics and physiology of the knee joint. they play a primary role in load transmission, assist the ligaments in ensuring knee stability, and thus protect against the onset of knee osteoarthritis. meniscal injuries are the most frequently encountered joint pathology and can cause pain, mechanical blocks, and recurrent effusions. the treatment of these injuries has progressively evolved from meniscectomy (removal of damaged meniscal tissue) to the use of meniscal sutures (where possible) to allow the preservation of the greatest amount of meniscus: numerous studies have shown a correlation between the amount of meniscus removed and the future onset of osteoarthritis (hutchinson ajsm 2014, harston kssta 2012). however, in some cases, especially in the presence of complex and/or chronic lesions, meniscectomy remains the only viable surgical solution even today. over time, months or years later, a subgroup of patients experiences symptoms such as pain, joint swelling, and mechanical overload of the compartment subjected to meniscectomy, a condition known as "post-meniscectomy syndrome." some of these patients will subsequently develop knee osteoarthritis, requiring invasive interventions such as partial or total knee replacement. meniscal allograft transplantation (mat) represents a valid therapeutic option for post-meniscectomy syndrome. this procedure aims to restore joint functionality and stability through the transplantation of a meniscus from a cadaver donor. mat has been widely adopted in clinical practice, showing success in reducing pain and improving joint functionality. current studies suggest that meniscal transplantation can offer significant protection against osteoarthritis, but the duration of this preventive effect is not yet fully understood. furthermore, there are no studies that can demonstrate the state of osteoarthritis with radiographic controls pre- and post-treatment at a follow-up of over 15 years.


Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65 at the time of surgery * both male and female * patients who underwent meniscal transplantation at the rizzoli orthopedic institute at least 15 years ago exclusion criteria: * patients who do not give consent to be included in the study * patients who are no longer reachable * presence of infection or hematologic, rheumatic, or coagulation disorders at the time of evaluation