Kornimate/medical-research-clean huggingface dataset:
patient reported experiences and outcomes associated with standard c-section wound closure versus stratafix/dermabond prineo wound closure (cs-preo)

Conditions: Cesarean Section; Complications, Wound, Infection (Following Delivery)

Summary: the aim of the study is to compare outcomes between patients receiving standard c-section wound closure compared to a wound closure bundle that includes stratafix sutures and dermabond prineo.

the purpose of this study is to evaluate patient experience and patient reported outcomes following cesarean delivery in women receiving either standard wound closure or a wound closure bundle which includes both stratfix sutures and dermabond prineo. patients in both study arms will complete established questionnaires capturing patient-reported experience measures (prems) and patient-reported outcome measures (proms).

Eligibility criteria:
inclusion criteria: 1. patient must be 18 years of age or older at time of recruitment 2. patients opting for a planned (elective) c-section (13-36 weeks gestation) will be eligible to consent. 3. patients must have internet access and/or a smartphone in order to access the digital platform to complete the study questionnaires 4. patients must speak and write in english as study questionnaires will only be provided in english 5. patients must have coverage from the ontario health insurance plan (ohip) exclusion criteria: 1. patients assessed by the participating surgeon with any conditions that may compromise their: * ability to consent or use the virtual care platform (e.g., patients with intellectual disabilities) * expectation of significant maternal complications that may affect the surgery 2. patients who enroll in the study but have an unplanned emergency c-section
clinical and refractive outcomes after contoura® refractive surgery planned using phorcides surgery planning software

Conditions: Refractive Errors

Summary: the objective of the current study is to prospectively evaluate 3-month clinical outcomes from lasik performed using the phorcides surgical planning software with contoura topography-guided ablation in both eyes of subjects with myopia and myopic astigmatism seeking refractive surgery for distance correction.

the objective of the current study is to prospectively evaluate 3-month clinical outcomes from lasik performed using the phorcides surgical planning software with contoura topography-guided ablation in both eyes of subjects with myopia and myopic astigmatism seeking refractive surgery for distance correction. data will be compared to published results for wavefront optimized lasik and lasik performed with contoura using other refractive algorithms. the hypothesis is that use of the phorcides planning software will result in a higher percentage of eyes with residual refractive cylinder ≤ 0.25d than will be achieved with wavefront-optimized (wfo) lasik. it is also expected that unaided postoperative visual acuity and visual symptoms will be improved.

Eligibility criteria:
inclusion criteria: * candidate for contoura excimer laser vision correction * gender: males and females. * age: 20 or older * willing and able to provide written informed consent for participation in the study. * willing and able to comply with scheduled visits and other study procedures. * good ocular health, with no pathology that compromises visual acuity (other than refractive error) * corrected preoperative visual acuity of 20/20 (0.0 logmar) or better in the eye being treated * meet contoura eligibility requirements (approved range): up to -8.00 d sphere, up to -3.00 d cylinder, and a spherical equivalent no greater than -9.00 d * desire good vision at distance in both eyes exclusion criteria: * corneal pathology (e.g. opacities, epithelial basement membrane dystrophy, fuchs' dystrophy, etc.) * previous corneal surgery (e.g., radial keratotomy, corneal refractive surgery or corneal transplant, dsaek, dmek, lamellar keratoplasty) * previous anterior or posterior chamber surgery (e.g., vitrectomy, laser iridotomy) * desire for good uncorrected near vision in one or both eyes * participation in (or current participation) any investigational drug or device trial within the previous 30 days prior to the start date of this trial * unsuitability for the trial, in the opinion of the investigator, for any reason * pregnancy or desire to become pregnant during the trial * intraoperative complications.
the effects of laxative-probiotic sequential treatment in the irritable bowel syndrome patients

Conditions: Irritable Bowel Syndrome

Summary: the laxative-probiotic sequential treatment might reduce the symptoms of ibs and alter the fecal microbiota of the patients in a more robust manner .

probiotics can regulate intestinal immunity, repair mucosal barrier, and reportedly exert therapeutic effects on ibs patients. the laxatives could also alter the gut microflora significantly, thus the laxative-probiotic sequential treatment might affect the symptoms and the composition of fecal microbiota in the ibs patients in a more robust manner .

Eligibility criteria:
inclusion criteria: * the presence of rome iii criteria for ibs ; * patients scheduled for colonoscopy examination or having negative screening examinations * aged between 18 and 65 years old exclusion criteria: * antibiotic, probiotic or laxative usage within 4 weeks. * organic gastrointestinal diseases * severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc. * pregnancy or lactation. * previous major or complicated abdominal surgery. * severe endometriosis and dementia

Keywords: fecal microflora ibs sequential treatment probiotic laxative
study to evaluate real-world effectiveness with palbociclib plus endocrine therapy as first-line/second-line treatment for hr+/her2- advanced breast cancer in japan

Conditions: Breast Cancer

Summary: this is a retrospective, multicenter, observational study in japan by medical record review of advanced breast cancer (abc) patients who have received palbociclib plus endocrine therapy (et) as first line or second line setting. for the purposes of this study, analyses will be descriptive in nature. no formal hypothesis testing is planned.


Eligibility criteria:
inclusion criteria: * diagnosis of hr+/her2- abc * age of 20 years or older at diagnosis of abc * patients that received palbociclib plus et in the first line or second line * patients who meet the criteria regarding the medical record below: * patients with any medical records (regardless of palbociclib use) for more than 6 months from palbociclib initiation or * patients with any medical records for less than 6 months from palbociclib initiation and who had specific events (death, disease progression, or treatment discontinuation of palbociclib due to adverse events) in the available records exclusion criteria: * patients who received chemotherapy as first line treatment. * patients who have previously participated or are participating in any interventional clinical trials that include investigational or marketed products. (interventional clinical trials for early breast cancer and later line after palbociclib will be acceptable, besides, patients participating in other investigator-initiated research or noninterventional studies can be included as long as their standard of care is not altered by the study.)

Keywords: retrospective multicenter observational effectiveness real-world progression free survival palbociclib endocrine therapy japan hormone receptor positive/ human epidermal growth factor negative (hr+/her2-) advanced breast cancer first-line therapy second-line therapy
comparative evaluation of pectoral nerve block type ii versus rhomboid intercostal and subserratus plane block in breast cancer mastectomy for postoperative analgesia: a randomized, controlled trial

Conditions: Breast Cancer

Summary: this study aimed to investigate the analgesic effects of pectoral nerve block type ii and rhomboid intercostal and subserratus plane block after radical mastectomy for breast cancer.this prospective, double-blind, randomized controlled trial recruited 67 female patients with complete follow-up records who underwent unilateral modified radical mastectomy (mrm) at inner mongolia baotou steel hospital from december 1, 2023 to december 1, 2024. subjects were assigned to the observation group and the control group at a 1:1 ratio using a random number table. among them, 30 patients who received pectoral nerve block (pecs ii) for analgesia were included in the observation group, and 30 patients who received rhomboid intercostal and subserratus (riss) block for analgesia were included in the control group. the primary outcomes included the 40-item quality of recovery (qor-40) scores at 6 hours and 24 hours after surgery, and the visual analogue scale (vas) pain scores in the post-anesthesia care unit (pacu), as well as at 2 hours, 6 hours, 12 hours, 24 hours, and 48 hours after surgery.t he secondary outcomes included the consumption of sufentanil in patient-controlled intravenous analgesia (pcia) after surgery, the number of effective compressions, the use of remifentanil during the operation, the number of additional analgesic administrations, the sleep quality on the first day after surgery, and the incidences of block-related complications and postoperative adverse events.


Eligibility criteria:
inclusion criteria: * patients met the diagnostic criteria of breast cancer; * tolerance to surgery and anesthesia exclusion criteria: * patients with severe systemic diseases or anesthesia problems: such patients were excluded to ensure safety and avoid the occurrence of irrelevant complications; * those with coagulation disorders; * patients with puncture contraindications or infections; * those allergic to local anesthetics; * those who refused to sign the informed consent form; * patients with cognitive or communication problems
effects of basic infection control skills license on knowledge and practice of health care workers

Conditions: Infection Control Training

Summary: considering the importance of infection control practices, madinah public health department launched a new license program for healthcare workers, the basic infection control skills license program (bicsl). bicsl has been launched to train healthcare workers all over the region in a scientific standardized way. to assess bicsl effectiveness, a non-randomized control study will be conducted in two of the general hospitals in madinah. an electronic bilingual self-administrated valid and reliable questionnaire will be used to evaluate the workers knowledge and practices before and after three and six months of the intervention. the knowledge and practice answers were scored and the scores were categorized to facilitate the comparison. a bicsl certified trainer will be conducting the intervention, a one to one training session. a spss program will be used to analyze the data. administrative and ethical approval was obtained from madinah health authority. the participants will complete an electronic consent before they fill the questionnaire. confidentiality and privacy as well as freedom to participate or not will be insured to all participants. this study will assess the license effectiveness in improve knowledge and compliance.


Eligibility criteria:
inclusion criteria: 1. working in the chosen hospitals. 2. health care worker (physician, nurse or technician) of any gender, age, or experience. exclusion criteria: 1. refuse to participate in the study. 2. have bicsl certificate before the study implemented. 3. on leave during study period.
music's impact on preoperative anxiety: heart rate variability study during cataract surgery

Conditions: Anxiety; Cataract Surgery; Heart Rate Variability

Summary: the goal of this randomized controlled trial is to evaluate heart rate variability (hrv)before and after listening to music in patients scheduled for cataract surgery under topical anesthesia, compared to patients who do not listen to music. our hypothesis is that the anxious population with a low hrv benefits from an anxiolytic effect of music to increase hrv levels.


Eligibility criteria:
inclusion criteria: * information and consent of the patient, * age greater than or equal to 18 years, * affiliation to a social security system, * benefiting from non-emergency ambulatory cataract surgery under topical anesthesia * not being under legal protection. exclusion criteria: * refusal to participate, * language barriers that are incompatible with a reliable assessment * use of beta-blockers, including eye drops * use of adrenergic, antiadrenergic, cholinergic and anticholinergic drugs * use of psychotropic drugs, anxiolytics.
effects of physical training on vascular function as a therapeutic target in pulmonary hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: the role of physical training in the treatment of pulmonary arterial hypertension (pah) is controversial. the aim of the project is to evaluate the effect of physical training on markers of endothelial function and integrity and to identify those biomarkers associated with a better therapeutic response in patients with pah and in an experimental model of pulmonary hypertension. methodology: 1) study in humans: sample size will be 50 patients with pah. responders and non-responders will be identified for a 12-week resistance training program. before and after the physical training program, endothelial microparticles and circulating vascular progenitor cells, and metabolomic and mitochondrial function parameters in circulating endothelial cells will be analyzed. patients will be identified in whom a more favorable response to the training program is obtained. additionally, investigators will evaluate the relationship between this response and the biomarkers both at baseline and their change with the training program. 2) study in a murine experimental model: investigators will study mice with pulmonary hypertension induced by the administration of semaxanib (su5416) and exposure to hypoxia for 3 weeks and control mice. half of them will exercise on a treadmill for 3 weeks. at the end of the program the right ventricular pressure will be measured and the animals will be sacrificed. morphometric studies in pulmonary and cardiac tissue, pulmonary endothelial function and metabolomic parameters in cardiac and skeletal muscle will be performed. differences in these variables between the different experimental groups will be analyzed.


Eligibility criteria:
inclusion criteria: * age over 18 years * functional class of new york heart association (nyha) ii-iii * diagnosis of pulmonary hypertension (ph) by right heart catheterization, as follows: * mean pulmonary arterial pressure (mpap) \>=25 mmhg * pulmonary vascular resistance (pvr) ≥240 din / s / cm5 * pulmonary interlock pressure (pcwp) ≤15 mmhg * patients with optimized pah treatment, including intensified treatment with diuretics and who have remained stable for at least 2 months before entering the study (changes in medical treatment are not expected during the entire 12-week study period) * be able to understand and be willing to sign the informed consent form exclusion criteria: * other type of ph (groups 2, 3, 4 or 5) * pregnant women * disability to exercise on a cycle ergometer or walk * acute infection or fever * any change in the treatment of the disease in the last 2 months * acute ischemic heart disease, unstable angina pectoris, exercise-induced ventricular arrhythmias, decompensated heart failure * history or suspicion of inability to cooperate adequately in the study

Keywords: exercise training biomarkers
comparison of methodology proposed by the sfar for the detection by videoconference of obstructive sleep apnea.

Conditions: Obstructive Sleep Apnea

Summary: the sfar (french society of anesthesiology and icu) proposed a method to detect osa (obstructive sleep apnea) patients via videoconference. the aim of this study is to compare the result of this method with the results of polysomnography (psg) which remains the gold standard in the detection of osa patients.

the sfar (french society of anesthesiology and icu) proposed a method to detect osa (obstructive sleep apnea) patients via videoconference. the aim of this study is to compare the result of this method with the results of polysomnography (psg) which remains the gold standard in the detection of osa patients. other methods, such as a predictive score, also exist. the accuracy of the french method compared to psg and the predictive scores is to be determined.

Eligibility criteria:
inclusion criteria: * all patients admitted in the clinique saint-luc of bouge for a polysomnography exclusion criteria: * patient's refusal
a multi-center, early feasibility study of using the mechanical tissue resuscitation™ (mtr™) therapy system for removal of excess fluid in subjects who have had a portion of their skull removed to expose the dura/brain and require drainage for fluid removal.

Conditions: Clinical Need for Craniotomy or Craniectomy

Summary: a multi-center, early feasibility study of using the mechanical tissue resuscitation™ (mtr™) therapy system for removal of excess fluid in subjects who have had a portion of their skull removed to expose the dura/brain and require drainage for fluid removal.

mechanical tissue resuscitation (mtr™) is intended for short-term (up to 7 days) use to externally drain excess fluid volume from the site of surgery in patients who have undergone a surgical procedure (craniotomy/craniectomy) for which a portion of the skull has been removed resulting in exposure of the dura/brain and require drainage of fluid. this is a single arm early feasibility study. the study will comprise of patients who will receive mtr™ therapy to remove fluid from the surgical site in patients that have undergone a craniotomy/craniectomy. the patient population will include male and female patients ages 22-65 who have undergone a surgical procedure to remove a portion of the skull to expose the dura/brain (craniotomy or craniectomy) in which the dura is intact or has been closed (repaired), and who, as an integral part of their care would require placement of a jackson pratt drain. patients will be treated with mtr™ for up to seven (7) days, with a follow up evaluation approximately one month post treatment. patients who have suffered a traumatic brain injury (tbi) and require such a surgical procedure are not to be included in the patient population for this early feasibility study.

Eligibility criteria:
inclusion criteria: 1. patient is willing and able to provide written informed consent. 2. the patient's age is ≥ 22 and ≤ 65 years. 3. the patient has a clinical need for a craniotomy/craniectomy and for which, as an integral part of their care, a jackson pratt (jp) drain would be placed at the surgical site. 4. the surgical case is classified as 'clean'. exclusion criteria: 1. patient has suffered a traumatic brain injury. 2. patient is pregnant or lactating. 3. patient's bmi = (weight (lb) x 703)/(〖height〗\^2 (inches)) \> 45; bmi may also be calculated at http://nhlbi.nih.gov/health/educational/lose_wt/bmi/bmicalc.htm 4. patient is participating in another clinical investigation . 5. patient's anticipated survival is \< 48 hours. 6. patient is incarcerated at time of hospital admission. 7. patient has a coincidental infection. 8. patient has thrombocytopenia (platelet count \< 150,000/µl). 9. patient has an international normalized ratio (inr) \> 1.5. 10. patient is an active opioid abuser. 11. patient is an active alcohol abuser. 12. there is active bleeding at the site of surgery.

Keywords: craniotomy craniectomy
alzheimer and sleep

Conditions: Alzheimer's Disease

Summary: the aim of the study is the analysis of two inhibitors of ach-e: galantamine and donépézil in over 65 years' old patients suffering from alzheimer disease (mmse between 20 and 26) without alzheimer's medication.

feasibility study, open, randomized, controlled, cross-over study in 65 years old patients.

Eligibility criteria:
inclusion criteria: * 65 and over years old * patients suffering from alzheimer disease * patient living with someone at home * written consent given exclusion criteria: * galantamine or donepezil hypersensibility * patient living alone and in a medicalized structure * concomitant medication * chronical diseases

Keywords: sleep alzheimer old patients
effects of al-lisaan urdu digital software for self-assessment and treatment of adult stutters

Conditions: Stuttering, Adult

Summary: the study plans to find the efficacy of a digital application/software, al-lisan that adult stutters can be used for assessment and management of their stuttering. the software has been developed with the help of a software engineer. after the current trends employed by speech language pathologists explored through qualitative study design, the manual which is under development process through a focused group in which assessment and treatment options of the software were finalized. the next step will include the reliability and validity of the software for assessment and management of adult stutters followed by finding the efficacy of the software. as this application will be in urdu language it will assist less literate and those living in peripheries to assess or provide self-treatment options to the persons who stutter. it will allow adults for self-assessment and treatment options in urdu language.

the term stuttering refers to the dis-fluent pattern of speech. in adult stuttering it's a learned pattern of dis-fluent production that may become the part of their speech permanently. it affects 1% of the worldwide population. there are many therapeutic techniques to treat the stuttering in adults. self-help therapy is common to use. besides the personalized treatment of self-help therapy by adult stutters, there are many digital applications available and used by many adult stutters worldwide. few are stammerapp, stamurai and smaat. the objective of the study is to develop a digital application/software that adult stutters can be used for assessment and management of their stuttering. this study being a part of phd project, started in march 2020 and until now, the current trends employed by speech language pathologists have been explored through qualitative study design. the manual was developed through a focused group in which assessment and treatment options of the software were finalized. the software has been developed with the help of a software engineer. the objective of this study is to find the effects of al-lisan urdu digital software for self-assessment and treatment of adult stutters. for this step we are applying for the grant. as this application will be in urdu language it will assist less literate and those living in peripheries to assess or provide self-treatment options to the persons who stutter. it will allow adults for self-assessment and treatment options in urdu language.

Eligibility criteria:
inclusion criteria: inclusion criteria will be stutters who are above the age of 19 and who have not taken regular therapy from last one year exclusion criteria: adults with neurogenic stuttering or any other organic cause will be excluded