Kornimate/medical-research-clean huggingface dataset:
evaluation of lymph nodes after neoadjuvant chemotherapy

Conditions: Breast Cancer

Summary: this research protocol is studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine therapy prior to having surgery (neoadjuvant therapy).

* this research study is a pilot study, which is the first time investigators are examining this study intervention locally; although this intervention has been studied nationally in published clinical trials. * in this research study, the investigators are studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine therapy prior to having surgery (neoadjuvant therapy). * a sentinel lymph node biopsy is a surgical evaluation of the lymph nodes in the underarm area in patients who have early breast cancer. approximately, two-five nodes are removed from the underarm area for evaluation. the sentinel lymph node biopsy is performed in patients with breast cancer to determine if there are cancer cells in the lymph nodes in the armpit. * the sentinel lymph node biopsy procedure is performed by injecting one or two dyes into the breast, which then travel to the armpit region via small vessels in the immune system. these nodes are called the sentinel lymph nodes. they represent the first nodes that drain the breast tissue. they are closely evaluated by a pathologist to determine if cancer cells are present. * this information allows physicians to know how far the cancer may have spread and recommend therapies accordingly. * if sentinel lymph node biopsy is determined to be accurate in patients who are known to already have cancer cells in the axillary lymph nodes who receive neoadjuvant therapy, then in the future, many of the patients in this population may be spared the procedure of a full axillary lymph node dissection, which removes a larger number of lymph nodes and thus has increased risks and side-effects.

Eligibility criteria:
inclusion criteria: * eligible patients will include any patients with biopsy-proven breast cancer and biopsy-proven axillary lymph node metastases at beth israel deaconess medical center who are candidates for neoadjuvant chemotherapy or neoadjuvant endocrine therapy. * a core needle biopsy or fine needle aspiration is acceptable for diagnosis of metastatic disease in lymph nodes. * patients will be identified as possible participants in the radiology imaging suites and breast surgery clinics. exclusion criteria: -patients with inflammatory breast cancer or distant metastases will be excluded from participating in this study

Keywords: breast cancer armpit lymph nodes cancer
study on ai-assisted multimodal diagnosis system of autoimmune pancreatitis

Conditions: Autoimmune Pancreatitis

Summary: the existing comprehensive diagnostic system for autoimmune pancreatitis (aip) is complex, with multidimensional clinical information including morphological changes and a lack of specific biomarkers. endoscopic ultrasound (eus) can provide all the elements for morphological diagnosis of aip, but the long learning curve and large observer differences make it difficult to popularize and promote. the cooperation units of the three regions in this project have found in the early stage that klebsiella pneumoniae (kp) induced follicular helper t cells (tfh) activation is an important mechanism of aip, but the identification of pathogenic components of the strain and clinical validation need to be explored. we have established a national multicenter aip queue in the early stage and extracted eus audio-visual features to establish a scoring model, but intelligent assistance is still needed to improve efficiency. therefore, we plan to integrate gut microbiota, tfh activation markers, and eus imaging features to establish an ai assisted multimodal diagnostic system for aip. this study will collaborate across multiple centers to identify and validate the components that induce tfh activation in kp bacterial cells, to extract eus pancreatic ultrasound features and optimize artificial intelligence assisted diagnostic algorithms, and to establish and validate an artificial intelligence assisted multimodal diagnostic system based on clinical information, biomarkers, and eus. the aim of this study is to provide new diagnosis and treatment evaluation methods for aip with high accuracy, convenience, and easy promotion for clinical practice.


Eligibility criteria:
inclusion criteria: * from the beginning of the study to the end of the study, patients with pancreatic solid lesions suspected or diagnosed with aip were treated at peking union medical college hospital and related research centers. * the patients themselves and their families understood and were willing to participate in this study, and signed an informed consent form. * the diagnosis of aip must comply with the criteria of the chinese guidelines for the diagnosis and treatment of autoimmune pancreatitis (2022). exclusion criteria: * individuals who are not suitable for endoscopic examination, including but not limited to: generally poor condition, severe cardiovascular and pulmonary diseases, and difficulty tolerating the examination, coagulation disorders and those who are deemed unsuitable for endoscopic examination by an endoscopist after a face-to-face consultation. * patients or family members are unable to understand the conditions and objectives of this study.

Keywords: autoimmune pancreatitis endoscopic ultrasonography artificial intelligence follicular helper t cells klebsiella pneumoniae
qipb in inguinal hernia

Conditions: Postoperative Pain

Summary: inguinal hernia repair is one of the most commonly performed surgical procedures. it is generally performed under regional anesthesia techniques, such as local anesthesia, peripheral nerve blocks, or neuraxial anesthesia (spinal or epidural anesthesia), or under general anesthesia. despite various available analgesic regimens, numerous studies have demonstrated that postoperative pain control remains inadequate. opioids, nonsteroidal anti-inflammatory drugs, and analgesics are frequently used for postoperative pain management. however, these medications are associated with uncertain efficacy and undesirable side effects. pain is a critical factor in the postoperative period, contributing to delayed ambulation and paralytic ileus, ultimately hindering early discharge.

inguinal hernia repair is one of the most commonly performed surgical procedures. it is generally performed under regional anesthesia techniques, such as local anesthesia, peripheral nerve blocks, or neuraxial anesthesia (spinal or epidural anesthesia), or under general anesthesia. despite various available analgesic regimens, numerous studies have demonstrated that postoperative pain control remains inadequate. opioids, nonsteroidal anti-inflammatory drugs, and analgesics are frequently used for postoperative pain management. however, these medications are associated with uncertain efficacy and undesirable side effects. pain is a critical factor in the postoperative period, contributing to delayed ambulation and paralytic ileus, ultimately hindering early discharge. recently, tulgar and colleagues introduced a novel fascial plane block known as the "quadro-iliac plane block". quadro-iliac plane block is performed within the quadro-iliac plane, located between the inner surface of the iliac crest and the posterior surface of the quadratus lumborum muscle. in their study, tulgar et al. bilaterally injected 40 ml of methylene blue into the quadro-iliac plane. they observed widespread dye dispersion along the anterior and posterior surfaces of the quadratus lumborum muscle, transversalis fascia, ilioinguinal, iliohypogastric, subcostal, and genitofemoral nerves, as well as the lumbar plexus. based on these findings, quadro-iliac plane block has been proposed as a potentially effective technique for managing acute or chronic pain in the lumbosacral, abdominal, and hip regions.

Eligibility criteria:
inclusion criteria: * patients aged 18-65 years * undergoing elective, * unilateral laparoscopic inguinal hernia repair * receiving general anesthesia exclusion criteria: * patients who refuse to provide consent * patients with contraindications to regional anesthesia * patients with impaired consciousness * patients with coagulopathy * patients with infections at the block site * emergency cases
exercise and pain neuroscience education for patients with neck pain: impact on pain and disability

Conditions: Neck Pain

Summary: this study will compare the effectiveness of pain neuroscience education and neck/shoulder traditional exercises versus pain neuroscience education and neck/shoulder suspension training exercises for patients with chronic idiopathic neck pain (cinp).

the investigators anticipate that 66 patients with chronic idiopathic neck pain will be randomized to receive pain neuroscience education and shoulder/neck traditional exercises (n=33) or pain neuroscience education and shoulder/neck suspension exercises (n=33). data on pain intensity (visual analogue scale), pain disability, neck flexor and extensor muscles endurance, scapulae stabilizers endurance, pain catastrophizing (pain catastrophizing scale), trait and state anxiety (state-trait anxiety inventory) and knowledge of pain neurophysiology (neurophysiology of pain questionnaire) will be collected. measurements will be taken before, after the intervention and at 3 months follow up. statistical analysis will be performed using a mixed-methods anova.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic idiopathic neck pain. exclusion criteria: * cervical radiculopathy * neck fractures * tumors * rheumatological disorders * any other serious cause of neck pain
chinese occupational population cohort of lifestyle and physical fitness (lifitchina)

Conditions: Lifestyle; Physical Fitness; Cardiovascular Diseases

Summary: the incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (cvd), are continuously rising among the occupational population in china, primarily comprising the middle-aged and young adults. unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. additionally, the level of physical fitness is influenced by postnatal lifestyles. lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. these factors may interact or have a synergistic effect, necessitating a comprehensive assessment. this project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. the study will track and follow individuals with or without any cvd metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of cvd-related health outcomes will be observed. the aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of cvd, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.


Eligibility criteria:
inclusion criteria: * adults between 18-59 years of age * occupational staff * willing to accept long-term follow-up exclusion criteria: * participants with previous cvd history such as myocardial infarction, stroke and severe aortic stenosis; * with cancer; * with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.; * with exercise contraindications; * duration of pregnancy; * refuse to sign the informed consent.

Keywords: lifestyle physical fitness cardiovascular diseases cohort
tigertriever distal vessels registry

Conditions: Ischemic Stroke

Summary: a registry study to collect data on the tigertriever device at restoring blood flow by removing clots in m2 or distal vessels in patients experiencing acute ischemic stroke, during commercial use.

tigertriever is a ce marked mechanical revascularization device indicated to restore blood flow by removing thrombus from a large intracranial vessel in patients experiencing ischemic stroke within 8 hours of symptom onset.

Eligibility criteria:
inclusion criteria: * patients who present with acute ischemic stroke, who can be treated within 6 hours of symptoms onset, who are either refractory to or ineligible for iv t-pa treatment and intend to be treated with thrombectomy. * patients ≥18 * nihss score of ≥2 * angiographically confirmed occlusion in a m2 or distal (medium to small) branch that is accessible to the tigertriever device (17 or 13) as determined by the vessel diameter (≥1mm). * anticipated life expectancy of at least 6 months from presentation * signed informed consent form by the patient or a legally acceptable representative. exclusion criteria: * extended infarct - ischemic changes \>1/3 mca territory / 100 ml tissue or aspect score \<5 * pre- stroke mrs ≥ 2 * unknown time of stroke symptom onset * vessel diameter \< 1mm * angiographically evident extreme vessel tortuosity that may preclude the device from reaching the target area. * occlusion/stenosis proximal to thrombus that precludes safe retrieval * medical co-morbidities including but not limited to: * uncontrolled coagulopathy such as international normalized ratio (inr) of \> 3.0 or platelets count \ 50 sec * serious concurrent medical illness: myocardial infarction, seizures, sepsis, uncontrolled diabetes, uncontrolled hypertension, brain tumor, renal impairment (egfr \<60). * baseline glucose \ 22.2 mmol/l * imaging features of: * raised intracranial pressure or significant mass effect (for example, midline shift, severe sulcal effacement, transcompartmental herniation) * intracranial hemorrhage * vascular malformation or aneurysm * significant vascular abnormality such as carotid dissection, complete carotid occlusion or large/medium vessel vasculitis * allergy/sensitivity to nickel-titanium or contrast media * females who are pregnant or lactating * unable to obtain informed consent from the patient or a suitable legal representative * any other contraindication to thrombectomy
evaluation of a new biocompatible pressure equalizing tube

Conditions: Otitis Media

Summary: otitis media is the most common illness in children and 5% to 10% of their symptom cause by fluids in their middle ear . the ome can cause hearing loss included poor development of speech and poor communication. the surgical procedure is considered simple and relatively safe, but several complications may occur after pressure equalizing tube insertion. the most prevalent complications are otorrhea, biofilm and formation of retraction pockets. otorrhea occurs in 30% to 83% of children with tube and is mainly due bacterial contamination of the middle ear either from external ear canal or impaired eustachian tube. swimming can facilitate the entry of bacteria into the middle ear from the ear canal through the pe tubes, and this assumption is reinforced by the statistically significant association between the rate of otorrhea and the non-utilization of ear plugs in children who swim (from 47% in children who used ear plugs to 56% in those who did not).

the researcher at beckman laser institute, university of california, irvine, develops new medical tool device call biocompatible pressure equalizing tube which can stop air passage and pressure equalization instantly, and can prevents water into the middle ear cavity. evaluate and compare the efficacy of a biocompatible pressure equalizing tube that enables air passage and pressure equalization almost instantly, while prevents the entrance of fluids, specially water, into the middle ear cavity. the biocompatible pressure equalizing tube can reduce the rate of postoperative otorrhea,air passage between outside and middle ear cavity,prevents formation of retraction pockets in tm and swimming with lower risk of otorrhea.

Eligibility criteria:
inclusion criteria: 1. male/ female at all age- newborn to adult. 2. non- pregnant woman. 3. diagnose of middle ear infection and plan for surgery procedure exclusion criteria: 1. pregnant woman 2. incompetent adults (i.e. individuals with cognitive impairment) 3. presence of immunodeficiency; cystic fibrosis; sickle cell disease; 4. another major systemic disease 5. congenital malformation of the external, middle, or inner ear 6. sensorineural hearing loss; otoneurologic disease 7. history of prior ear surgery such as tympanoplasty, tympanomastoidectomy, or mastoidectomy; cholesteatoma; chronic mastoiditis; intratemporal or intracranial suppurative complications of otitis media 8. use of ototoxic medication (except topical use)

Keywords: middler ear infection
ruxolitinib combined with dexamethasone for hlh

Conditions: Hemophagocytic Lymphohistiocytosis

Summary: a protocol named as "hlh-dr" for patients with refractory and secondary hemophagocytic lymphohistiocytosismay.

a modified protocol about ruxolitinib combined with dexamethasone which includes oral ruxolitinib (2.5 mg twice daily for patients if the age\<14 years and the weight \<25kg，5 mg twice daily for patients if the age\<14 years and the weight≥25kg, 10mg twice daily for patients if the age ≥14 years and\<18 years）. dexamethasone (10mg/m2.d) delayes for the first 2 weeks （form week 1 to 2），(5mg/m2.d) from week 3 to 4，(2.5mg/m2.d) from week 5 to 6），1.25mg/m2.d for week 7，and dropped off on week 8. every 2 weeks, patients can be evaluated based the diagnosed index

Eligibility criteria:
inclusion criteria: * secondary and refractory hlh. exclusion criteria: * family hlh.
combination of steroid and humanized cd25 monoclonal antibody as first-line therapy for agvhd

Conditions: Acute Graft Versus Host Disease

Summary: the first-line treatment of acute graft-versus-host disease with humanized cd25 monoclonal antibody combined with glucocorticoid was used to study the remission rate of acute graft-versus-host disease, the cumulative incidence and remission rate of severe acute graft-versus-host disease, gvhd-free survival rate, all-cause mortality and quality of life evaluation, and safety evaluation for prevention programs.


Eligibility criteria:
inclusion criteria: * ( 1 ) diagnosis of grade ii to iv acute graft-versus-host disease after hematopoietic stem cell transplantation. ( 2 ) older than or equal to 18 years old. ( 3 ) informed consent can be signed by themselves. ( 4 ) hiv negative, hbv, hcv negative. ( 5 ) informed consent must be signed before the start of the study procedure. the informed consent must be signed by the patient himself or his immediate family. considering the patient 's condition, if the patient 's signature is not conducive to the treatment of the disease, the informed consent will be signed by the legal guardian or the patient 's immediate family. exclusion criteria: * • (1) diagnosed as vod/sos. * (2) uncontrolled infection at enrollment; requires mechanical ventilation or is hemodynamically unstable at the time of enrollment; * (3) has severe hepatic insufficiency (defined as child-pugh class c; has serum aspartate aminotransferase (ast) or alanine aminotransferase (alt) \> 5 xthe upper limit of normal (uln) or serum total bilirubin \> 2.5 x uln. * (4) has end-stage renal impairment with a creatinine clearance less than 10 ml/min. * (5) has both moderate hepatic insufficiency and moderate renal insufficiency; * (6) has documented positive results for human immunodeficiency virus antibody (hivab), hepatitis c virus antibody (hcv-ab) with detectable hcv rna, or hepatitis b surface antigen (hbsag) within 90 days prior to enrollments; * (7) has active solid tumor malignancies with the exception of localized basal cell or squamous cell skin cancer or the condition under treatment (e.g., lymphomas). * (8) suffering from mental disorders or other conditions and unable to cooperate with the requirements of study treatment and monitoring; * (9) unable or unwilling to sign the consent form; * (10) patients with other special conditions assessed as unqualified by the investigator

Keywords: agvhd humanized cd25 monoclonal antibody glucocorticoid
evaluation of the vulnerable carotid atherosclerotic plaque: a clinical multicenter study

Conditions: Ultrasound

Summary: evaluation of carotid plaque vulnerability based on ultrasound imaging features， proteomics and metabolomics: a clinical multicenter study

carotid artery plaque tissue specimen for proteomics. blood were collect for metabolomics.

Eligibility criteria:
inclusion criteria: 1. patients who meet the cea surgical indications; 2. age\>18 years old; 3. patients who sign informed consent forms exclusion criteria: 1. those with severe calcification of plaques and obvious acoustic shadows, and poor image quality; 2. contraindications to ultrasound contrast, such as those who are allergic to contrast agents; 3. intracardiac right to left shunt;
diclofenac potassium with or without vaginal dinoprostone prior to hysterosalpingography

Conditions: Infertility, Female

Summary: the aim of our study is to determine the efficacy of oral diclofenac potassium with or without vaginal dinoprostone prior to hysterosalpingography in primarily infertile patients on the pain scores during hsg.

hysterosalpingography is a diagnosis procedure in the evaluation of infertile women and considered to be the traditional and the gold standard in the assessment of the patency of the fallopian tubes. the major disadvantage of hysterosalpingography is pain. in a study reported the patients complained of moderate to severe pain during the procedure. it is reported that some patients undergoing hysterosalpingography was more stressful and anxiety and effect on pain scores.

Eligibility criteria:
inclusion criteria: * primary infertility female came for hsg exclusion criteria: * any patient has contraindication to hsg