Kornimate/medical-research-clean huggingface dataset:
a clinical trial of tqc3721 suspension for inhalation in patients with moderate to severe chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: to evaluate the efficacy and safety of tqc3721 suspension for inhalation in patients with moderate to severe chronic obstructive pulmonary disease (copd)


Eligibility criteria:
inclusion criteria: * sign informed consent before the test and fully understand the test content, process and possible adverse reactions. * male and female subjects aged 40 to 80 years old (including the cut-off value). * body mass index (bmi) in the range of 18-30kg/m2 (including the critical value) * subjects have no pregnancy plan and voluntarily use effective contraception for at least 1 month from screening to the last use of the study drug. * diagnosed as a copd patient according to the the global initiative for chronic obstructive lung disease (gold) 2024 criteria. * able to conduct acceptable and reproducible lung function tests. * copd clinical stability within the 4 weeks prior to screening visit (v1 visit) and between v1 visit and v2 visit. * smoking history ≥ 10 pack years. exclusion criteria: * history of life-threatening copd, including admission to the intensive care unit and/or the need for intubation. * screening for copd acute exacerbations that require systemic hormone therapy prior to the visit. * screening for hospitalization history due to copd within the first 6 months. * use antibiotics for respiratory tract infections within 6 weeks prior to screening or randomization visit. * chest computed tomography (ct) revealed clinically significant abnormalities and concluded that the abnormalities were not caused by copd. * previous lung resection or lung reduction surgery. * pulmonary rehabilitation treatment. * previously received tqc3721 treatment. * patients who received immunotherapy within the first 4 weeks of the screening period. * the patient has a history of diseases that are currently beyond their control. * history or current evidence of cardiovascular disease with clinical significance. * history of cured or untreated malignant tumors in any organ or system within the past 5 years. * screening for clinically significant safety laboratory test outliers determined by the researcher during the visit. * those who require oxygen therapy or intermittent oxygen therapy. * receive attenuated live vaccine within 28 days prior to randomization, inactivated vaccine within 7 days, or study. * planned vaccine recipients during the period. * individuals who have participated in any drug or medical device clinical trials prior to screening. * researchers believe that there are other situations that are not suitable for participation in the study.
low-dose dual-energy ct for the pre-surgical planning of patients with progression of scoliosis

Conditions: Scoliosis

Summary: the aim of the study is to evaluate the diagnostic accuracy of low-dose dual energy ct in the pre-surgical planning of patients with progression of scoliosis

ct imaging is the gold standard for assessing bone dysmorphism and vertebral morphometry during the pre-surgical planning of vertebral arthrodesis. it is necessary in the definition of the fixation points to avoid malposition of transpedicular screws and potential visceral, vascular or neurological damage. it is known that multislice ct involves an increased radiation exposure for patients, while dual-energy ct uses a low-dose acquisition protocol and veo reconstruction software. the aim of the study is to evaluate the diagnostic accuracy of low-dose dual energy ct in the pre-surgical planning of patients with progression of scoliosis who are candidated for vertebral arthrodesis.

Eligibility criteria:
inclusion criteria: * patients with progression of scoliosis without vertebral arthrodesis * patients able to maintain immobility for the duration of the exam * patients from 5 to 20 years old exclusion criteria: * pregnancy * vertebral arthrodesis * patients unable to maintain immobility for the duration of the exam * non-compliant patients * obese patients * patients younger than 5 years old or older than 20 years old

Keywords: scoliosis low dose arthrodesis dual-energy ct
the role of elastography in the diagnosis of thyroid nodules

Conditions: Thyroid Nodule; Thyroid Neoplasms

Summary: the primary objective of this study is to evaluate the role of elastography (along with echographic and cytological data) as a diagnostic tool for thyroid cancer

ultrasound is considered the first line examination in the exploration of the thyroid nodule. echotexture analysis often identifies nodules at risk of malignancy, but does not replace or exclude an additional cytological exploration. cytology, although effective, also has limitations, particularly when samples are vesicular and it is difficult discern between a benign or malignant state. the creation of a noninvasive method in this context could help to avoid invasive tests or "useless" surgical procedures. ultrasound elastography, which assesses tissue deformability, may provide valuable information concerning benign soft tissue characteristics, whereas malignant lesions are harder in consistency. interest in this method, already proposed for other organs, has recently increased due to the emergence of specifically created software that enables objective evaluation of the hardness of the nodule during a conventional ultrasound analysis. the main hypothesis of this study is that elastography should allow better selection of candidates for thyroid surgery.

Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient is available for six months of follow-up * the patient is programmed for surgical excision of all nodules determined to be not benign according to cytological criteria exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * the patient is pregnant * the patient is breastfeeding * the patient has a contraindication for a treatment used in this study * the patient has a contraindication for surgical excision of his/her thyroid nodule * the patient refused to be operated

Keywords: elastography cytology
teletechnology-assisted home-based exercise program for severe covid-19

Conditions: COVID-19; Telerehabilitation

Summary: the aim of this study is to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in covid-19 survivors. the main questions it aims to answer are: * the change of six-minute walk distance * the change of time of one-minute sit-to-stand test * the change of maximal strength of upper-limb, lower-limb and respiratory muscle * the change of quality of life participants in the home-based pulmonary rehabilitation group will receive teletechnology-assisted consultations (either by videotelephony or telephone calls) for every 1-2 weeks during the intervention period, and participants in the usual care group will not receive teletechnology-assisted consultations during the intervention period.


Eligibility criteria:
inclusion criteria: * patients are 20 years or more with severe (severe pneumonia) to critical (acute respiratory distress syndrome, sepsis, or septic shock) covid-19 during hospitalization after deisolation. * patients are 65 years or more, or ever receiving oral antiviral treatment after deisolation. * patient have the ability to ambulate on level surface without direct contact of another person, have telecommunication device(s), and provide consent to receive teletechnology-assisted rehabilitation. exclusion criteria: * patients are pregnant or planning for pregnancy. * patients have cognitive dysfunction, learning disability, uncontrolled arrhythmia or hypertension, or any medical diagnosis other than covid-19 that would prominently influence their ability to follow instructions and perform exercise.

Keywords: pulmonary rehabilitation
entecavir versus lamivudine for preventing the risk of hepatitis b reactivation in nhl

Conditions: Non-Hodgkin Lymphoma; Hepatitis B Reactivation

Summary: the aim of this study is to prove the superiority of entecavir over lamivudine for preventing the risk of hepatitis b virus reactivation in patients with non-hodgkin lymphoma on chop/r-chop.

in china, previous studies showed patients with non-hodgkin lymphoma (nhl) are likely to have hepatitis b virus (hbv) infection. the risk of hbv reactivation is high when patients were treated with chop, especially in combination with rituximab. the aim of this study is to compare entecavir with lamivudine, 2 commonly used anti-virus agents, for preventing the risk of hbv reactivation in patients with nhl on chop/r-chop.

Eligibility criteria:
inclusion criteria: * previously untreated nhl suitable for chop/r-chop treatment * age range 18-80 years old * hbsag positive with high level of hbv dna * eastern cooperative oncology group performance status 0-2 * life expectancy of more than 3 months * adequate organ function exclusion criteria: * primary or secondary central nervous system involvement * with hepatitis c virus infection * previous serious cardiac disease * history of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * pregnant or lactating women * serious uncontrolled diseases and intercurrent infection

Keywords: nhl hbv entecavir lamivudine
phase ii evaluation of exhaled nitric oxide (no)

Conditions: Lung Cancer

Summary: the goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.

nitric oxide breathing test: if you agree to take part in this study, you will have a nitric oxide breathing test performed before, during and after radiation therapy. you will you will have a nitric oxide breathing test 1 week before you complete radiation therapy, when you complete radiation therapy, and at each follow-up visit for 6 months. to complete this test, you will breathe out into a device called a nitric oxide breath analyzer for 10 seconds. you will repeat this test 3 times. the results of this test will give researchers information about possible inflammation in your lungs. the results of this test will be compared with any breathing symptoms you may experience during the same time period. for your first breath testing session and any session when your nitric oxide level is at least 1 ½ times higher than the first session, you will repeat the test for up to 5 different "breathe out rates". this additional testing will allow the researchers to find where in your lungs the nitric oxide increase is coming from. breathing symptoms questionnaire: on the day of each breathing test, you will complete a questionnaire about your breathing and any symptoms you may be experiencing. this should take about 10 minutes. after radiation therapy is complete, some of the monthly questionnaires will be completed by the data coordinator using telephone interviews. length of study: your participation in this study will be over after you complete the last breath testing session. this is an investigational study. the nitric oxide breath analyzer used in this study is fda approved and commercially available for measuring breathed out nitric oxide levels in patients with asthma. its use to predict lung inflammation caused by radiation therapy is investigational. up to 150 patients will take part in this study. all will be enrolled at md anderson.

Eligibility criteria:
inclusion criteria: 1. patients will sign consent for the study. 2. patients with pathologic diagnosis of esophagus or lung cancer. 3. patient plans to receive radiation treatment at md anderson. 4. patient will receive \>/= 5 weeks of thoracic radiotherapy. 5. patients \>/= 18 years of age. exclusion criteria: 1. patients who have asthma. 2. women of childbearing potential (a woman of child-bearing potential is a sexually mature woman who has not undergone a hysterectomy or who has not been naturally postmenopausal for at least 24 consecutive months \[i.e., who has had menses at any time in the preceding 24 consecutive months\]) must practice effective contraception (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide) throughout the study.

Keywords: radiation pneumonitis rp nitric oxide no thoracic esophagus cancer lung cancer radiation therapy radiotherapy rt xrt airway alveolar nitric oxide breath analyzer questionnaires
vocal feature analysis algorithm for covid-19 detection

Conditions: COVID-19

Summary: this is an observational, prospective, non-randomized, non-significant risk study collecting voice recordings from subjects who are being tested for covid-19 by laboratory analysis of specimens obtained by nasal or naso-pharyngeal (np) swab. patients record their voices through an app on their mobile phone. patients and health care providers will be blinded to the swab test results during phase 2 of the study.

the primary objective of this observational study is to determine if the vocal feature analysis (vfa) algorithm developed by soniphi can screen for the covid-19 condition from voice recordings. patients eligible for the study are those being tested for covid-19 based on molecular diagnostic testing of specimens obtained by nasal or nasopharyngeal swab. no clinical decisions will be based on the recordings. the results of the algorithm analysis will not be made available to the subjects or their healthcare providers during or after the study.

Eligibility criteria:
inclusion criteria: 1. male or female, aged \> 18 years 2. provide a valid electronic informed consent form 3. eligible patients are those meeting soc guidelines for swab tests for covid-19 and those providing an evaluable sample. 4. stated willingness to provide evidence of their lab test results 5. pregnant or lactating women may participate exclusion criteria: 1. presence of tracheostomy or past tracheostomy with permanent change to the voice due complications that involved the vocal cords. 2. prior surgery which may influence the vocal cords, e.g., laryngeal, tracheal or esophageal surgery 3. prior head, neck or throat cancer treated with radical neck dissection and/or radiation therapy that may influence the vocal cords 4. treatment with another investigational drug or device within 30 days prior to signing consent form
automatic versus intentional movement exercises to enhance arm functions after stroke

Conditions: Stroke; Upper-limb Paresis

Summary: many patients retain upper-limb motor impairment following stroke. most conventional rehabilitation techniques are aimed to improve motor intentional movement by repeated exercises. these techniques require attentional load and are responsible for significant fatigue that probably represents a limiting factor. alternatively, the automatic control of action is now well documented. a rehabilitation method based on this principle could allow recovery of more natural movements. hypothesis: stimulating automatic motricity improves upper-limb motor skills compared with a rehabilitation technique based on intentional movements.


Eligibility criteria:
inclusion criteria: * all subjects must be between the ages of 18-80 and must not be pregnant * patients volunteer to participate in the study, with a written informed consent signed * affiliation to a national health insurance program * hemiplegia after stroke * stroke onset \>6 weeks and \<4 years prior to study enrollment * patients able to perform the exercises on the automated table exclusion criteria: * pregnancy * excessive pain in any joint of the paretic extremity (vas\>5) * coexistent major neurological or psychiatric disease as to decrease number of confounders * subjects with global aphasia and deficits of comprehension * any substantial decrease in alertness, language reception, or attention that might interfere with understanding instructions for motor testing

Keywords: stroke hemiplegia automatic pilot upper-limb rehabilitation
nutritional risk factors and colorectal surgery

Conditions: Colorectal Cancer; Nutrition Related Cancer

Summary: this observational study aims to learn about the relationship between the nutritional status of patients with colorectal cancer and clinical outcome after colorectal surgery. the main question\[s\] it aims to answer are: * which anthropometric, laboratory and specific parameters best define that patient is at nutritional risk * will patients that are at nutritional risk stay longer in the hospital after surgery than those who are not at nutritional risk patients will be preoperatively examined anthropometrically, radiologically and laboratoryally. postoperatively, the course of their treatment will be monitored, as well as the monitoring of postoperative complications. a group of patients with and without malnutrition will be compared.


Eligibility criteria:
inclusion criteria: * colorectal cancer * first operation of this type exclusion criteria: * urgent surgery * peritoneal carcinomatosis
effect of fmd on colorectal cancer patients

Conditions: Fasting Mimicking Diet; Colorectal Cancer

Summary: extensive preclinical evidence suggests that short-term fasting and fasting mimicking diets (fmds) can protect healthy cells and render cancer cells more vulnerable to chemotherapy and other therapies. however, fasting is difficult for the old and frail subjects.therefore, fmds may be more suitable for postoperative dietary intervention in cancer patients. colorectal tumors have high glucose consumption, which makes tumor cells very sensitive to changes in nutritional metabolism of the surrounding environment (such as diet restriction / fasting). previous studies have shown that cyclic fmds are safe and feasible for cancer patients receiving chemotherapy alone. however, the effects of the fmd in patients under radical surgery for colorectal cancer have not been evaluated so far. this study aims to evaluate the impact of fmds on postoperative recovery and outcomes of patients with colorectal cancer.


Eligibility criteria:
inclusion criteria: 1. age 18 \~ 80 years old 2. patients undergoing radical colorectal cancer resection for the first time 3. preoperative clinical tumor stage iii 4. asa grade i-iii grade 5. with bmi 19-32 kg/m2 6. adequate liver function, adequate renal function and normal cardiac function 7. willing to participate in the research of the subject and agree to follow up regularly exclusion criteria: 1. evidence of distant metastasis before surgery 2. before surgery, have received treatment of neoadjuvant chemotherapy 3. type 1 diabetes or intensive insulin therapy 4. allergies for fmd content 5. combined with severe primary diseases such as severe immune system or autoimmune system or long-term using of glucocorticoids or immunosuppressant 6. history of opioid abuse, mental illness or cognitive impairment
renal replacement therapies decision aids

Conditions: End-stage Renal Disease; Renal Replacement Therapy; Decision Aid; Decision-making

Summary: different renal replacement therapy methods will cause significant impacts on the physical, mental, and social for patients with end-stage renal disease. application shared decision-making should be able to effectively assist patients in choosing suitable renal replacement therapy. currently, most of the patient decision aid of renal replacement therapy are written health education leaflets, which have problems such as too many words, more difficult content, and inconvenience. in shared decision-making, even though different treatment options are communicated to patients, there is still a gap between "understanding" and "real experience", it will be creating uncertainty of decision, and emphasizing true situational learning strategies should be a viable auxiliary method. therefore, this study aims to develop a web-based patient decision aid of renal replacement therapy and integrates situational learning strategies into it. first, investigators have conducted a qualitative study to explore the related experience of patients with end-stage renal disease the decision-making needs in renal replacement therapy choice, and the experience and barrier of reading paper patient decision aid. next, based on the results of the pilot study, the modified delphi method will be used to collect the opinions of experts, and the situational learning theory will be integrated into the patient decision aid to develop the web-based situation renal replacement therapies patient decision aid. after completion, investigators will apply quasi-experimental, a repeated measurement that will be adopted to analyze the effectiveness of web-based patient decision aid of renal replacement therapy in shared decision-making in patients with end-stage renal disease.


Eligibility criteria:
inclusion criteria: * diagnosed by nephrologists as patients with chronic kidney disease, and gfr \<30 ml/min/1.73m2. * as a patient admitted to the "pre-esrd care plan". * clear awareness, ability to communicate in mandarin and taiwanese, and agree to participate in the research. * those who are unable to answer the questions without other serious diseases or diseases affecting the mind. exclusion criteria: * those who cannot freely choose hemodialysis or peritoneal dialysis due to absolute contraindications.

Keywords: end-stage renal disease renal replacement therapy patient decision aid shared decision-making
shared decision making in patients with thyroid nodules

Conditions: Thyroid Nodule; Thyroid Cancer

Summary: the objective of this project is to evaluate a treatment decision aid for patients with low risk thyroid cancer.


Eligibility criteria:
inclusion criteria: -clinical diagnosis of low risk thyroid cancer exclusion criteria: -does not have the cognitive capacity to provide consent

Keywords: shared decision making, decision aid