Kornimate/medical-research-clean huggingface dataset:
randomized study of yohimbine treatment for type 2 diabetes patients carrying a specific genetic risk variant

Conditions: Type 2 Diabetes

Summary: the investigators have recently discovered a genetic variant in an adrenergic receptor that leads to increased risk for type 2 diabetes. the investigators have also seen that blockers of that receptor improves impaired insulin secretion in animals. the investigators will now test the blocker in patients with type 2 diabetes with or without the risk variant in an effort to make diabetes treatment more individualized.

we have recently discovered a genetic variant in an adrenergic receptor that leads to increased risk for type 2 diabetes. we have also seen that blockers of that receptor improves impaired insulin secretion in animals. we will now test the blocker in patients with type 2 diabetes with or without the risk variant in an effort to make diabetes treatment more individualized. patients will receive two different doses of the blocker and the effect will be measured with oral glucose tolerance tests. the study is a randomized placebo-controlled study.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * informed consent * age 18-70, for females only postmenopausal exclusion criteria: * heart disease * anxiety disorder * antidiabetic treatment other than metformin * adrenergic blockers * ulcus * allergy to any component in the capsules

Keywords: genetics type 2 diabetes insulin secretion
randomized controlled trial of standard versus systemic decolonization therapy for the eradication of methicillin-resistant staphylococcus aureus (mrsa) colonization

Conditions: Methicillin-resistant Staphylococcus Aureus

Summary: mrsa decolonization may reduce the risk of subsequent mrsa infection and further transmission. a recent randomized controlled trial demonstrated that systemic decolonization may be safe and effective among hospitalized patients when compared to no treatment. as a large number of the investigators patients require re-admission and further transmission may take place in the community, the investigators are comparing the standard decolonization protocol for mrsa eradication to the systemic decolonization protocol among an ambulatory population. standard decolonization protocols, which use only topical agents, are limited in efficacy. the method of systemic decolonization to be studied here appears to have greater efficacy than the standard approach using only topical agents. however, concerns have been raised that the increased use of systemic antibiotics may lead to increased levels of drug resistance adverse effects, without sustained decolonization. this study seeks to provide further data to help answer these questions and provide guidance for further policy development and implementation.


Eligibility criteria:
inclusion criteria: * any patient colonized with mrsa exclusion criteria: * currently on treatment with antibiotics * pregnant or breastfeeding women * active infection * hepatic cirrhosis or abnormal inr due to liver disease * decolonization in the previous two (2) months * mrsa bacteria resistant to one or more of the study medications * ast and alt levels more than five times the upper limit of normal.

Keywords: mrsa doxycycline rifampin mupirocin chlorhexidine gluconate decolonization methicillin-resistant staphylococcus aureus
burn scar appearance after treatment with fractional carbon dioxide (co2) laser

Conditions: Scars

Summary: the purpose of this study is to determine if fractional carbon dioxide laser treatment of a burn scar is a more effective method for improving the appearance of scars than the current available treatments.


Eligibility criteria:
inclusion criteria: * have a mature burn scar and desire revision * fluent in english * must reside in the los angeles vicinity for the duration of the study exclusion criteria: * previous history of scar revision * non-english speakers * pregnant or cognitively impaired subjects

Keywords: burn scar fractional carbon dioxide laser scar revision
the effect of music on anxiety in patients prior to gastrointestinal procedures

Conditions: Music; Anxiety

Summary: this study investigated the effect of listening to self-selected music on anxiety and physiological responses in patients prior to gastroscopy. a randomized controlled trial was conducted, in which patients scheduled for gastroscopy in a medical center located in taipei, taiwan, were enrolled. the experimental group listened to self-selected music with earphones for 15 min before the procedure, whereas the control group rested for 15 min. blood pressure (bp), heart rate, respiratory rate, and anxiety level were measured immediately before and after the intervention.

potential study patients were referred from physicians. the research assistant described the study's purpose and procedure to the patients and explained their right to refuse or withdraw from the study without jeopardizing their procedure. in addition, the privacy of each patient's data was ensured by storing the data in a file that required a password to access. personal identification was by no means included in the data file. in addition, the participants were assured that their data would not be used for purposes other than this research. after obtaining their consent, the participants were randomly assigned into the music group or the control group by drawing lots. we brought the participants to a separate and quiet room in the waiting area to prevent environmental interference. first, the participants completed the study questionnaire; then, the research investigator measured their physiological parameters. the participants in the music group selected the music they preferred from different genres, namely chinese pop, taiwanese songs, western classical , light music, western pop, and nostalgic music. if a participant had no particular preference, music with a low tone, regular rhythm (approximately 60-80 beats per minute), and soft melody (light music, 5%) was used, as recommended by a previous study. during the 15-min intervention period before the gastroscopy procedure, the experimental group rested by listening to music and sitting on a comfortable chair, whereas the control group rested only by sitting on a comfortable chair. after the 15-min intervention, the patients' anxiety and physiological parameters were reassessed.

Eligibility criteria:
inclusion criteria: * 20 years of age or older * able to respond to questionnaires in chinese. were excluded from the study. exclusion criteria: * with hearing loss who did not wear hearing aids * patients who were unable to communicate verbally * patients diagnosed with dementia, mental illness defined by the diagnostic and statistical manual of mental disorders, fourth edition, or cognitive impairment

Keywords: music anxiety digestive tract endoscopy
bladder diary for female storage luts

Conditions: Urinary Urge Incontinence; Urinary Frequency More Than Once at Night; Stress Urinary Incontinence

Summary: storage urinary symptoms are the most complained of lower urinary tract symptoms (luts) and need further classification. this original study aims to derive a novel classification algorism for female storage luts according to a 3-day bladder diary (bd). further feasibility of the application was also evaluated.

between july 2009 and december 2021, all women with storage lower urinary tract symptoms (luts) who visited the urogynecological department of a medical center were included. women without complete data of a 3-day bladder diary (bd) were excluded from this study. the women were allocated into 12 groups according to the study flowchart based on their luts, including urinary urgency, stress urinary incontinence, urgency urinary incontinence, nocturia and frequency. medcalc software was used for statistical analysis. analysis of variance (anova) was applied, and a p-value of less than 0.05 was considered as statistically significant. post-hot analyses by the student-newman-keuls test were performed only in those comparisons with p \< 0.05 after anova.

Eligibility criteria:
inclusion criteria: * women more than 20-years-old * with storage lower urinary tract symptoms * finished a 3-day bladder diary exclusion criteria: * no lower urinary tract symptoms * pregnant * incomplete data of bladder diary

Keywords: storage lower urinary tract symptom female bladder diary
does numerical and pictorial information on risk and benefit affects the uptake of colorectal cancer screening?

Conditions: Colorectal Cancer Screening

Summary: to establish whether provision of numerical data, framed as event rates and illustrated by pictograms, and including figures for all-cause mortality, affects subjects' attitudes to colorectal cancer (crc) screening. design and intervention. randomised questionnaire and telephone study comparing the responses of a control group given the standard national health service (nhs) crc screening information with the responses of an intervention group given the same information but enhanced with additional numerical and pictorial information. setting


Eligibility criteria:
inclusion criteria: age 60 - 70 - exclusion criteria: * no previous cancer or previous colonoscopy not able to give informed consent

Keywords: colorectal cancer consent screening
sildenafil in sever intrauterine growth retardation

Conditions: Intra-Uterine Growth Retardation

Summary: severe fetal growth restriction (fgr) complicates approximately 0.4% of pregnancies and severely increases the risk of perinatal morbidity and mortality.sildenafil citrate may offer a potential therapeutic strategy to improve uteroplacental blood flow in iugr pregnancies.

the aim of our study is to evaluate the effect of sildenafil citrate therapy on severe early and late onset intrauterine growth retardation.a total of 46 patients with severe early onset intrauterine growth retardation will be enrolled in a prospective case control study . patients will randomly be allocated to two groups with 23 patients in each group.sildenafil citrate therapy may increase the likelihood of increased growth velocity \[measured by abdominal circumference (ac) (ultrasound)\] for fetuses of pregnancies complicated by severe early-onset iugr .sildenafil is a potent and selective inhibitor of cgmp-specific phosphodiesterase type 5 (pde5), which is responsible for degradation of cgmp which results in increased levels of cgmp, leading to smooth muscle relaxation. placental disease, consequent on deficient uteroplacental blood flow, includes fgr, pre-eclampsia, and placental abruption and has been implicated in more than 50% of iatrogenic premature births .for this reason, the problem of severe fgr forms a substantial portion of the population that tertiary care centres care.

Eligibility criteria:
inclusion criteria: • pregnancy complicated by severe iugr \[abdominal circumference (ac)\< 5th percentile\] the gestational age \<25 weeks or an estimate of the fetal weight was \<600 gm (excluding known fetal anomaly/syndrome and/or planned termination) ( von dadelszen.et al;2011). exclusion criteria: * known aneuploid anomaly, syndrome congenital infection. * if there is a plan to terminate the pregnancy.
the influence of stability boots on gait pattern in healthy adults

Conditions: Rehabilitation After Ankle Injuries

Summary: after an ankle injury like distorsions, fractures or arthrodeses, or congenital defects ankle support limit the range of motion in the joint, help pain relief, control loading of the injured tissues and promote recovery of a normal gait pattern. gait analysis is applied in orthopedics, sport science and rehabilitation. numerous measure systems and methods enable accurate analysis of human movement. the study is set to describe and compare the gait analysis of two modifiable stability boots (ortho® tri-phase and the vacoped®) on the standard walking parameters during two conditions (level and ramp walking) in healthy adults and draw comparisons with a control indoor shoe.

the participants are joining one session in the gait lab. here the are measured during walking with normal shoes and two modifiable stability boots. the duration of a session is typically 3 hours.

Eligibility criteria:
inclusion criteria: * healthy * 18-45 years old * shoe size 5,6,9 or 10 exclusion criteria: * injuries of the lower limbs * previous surgeries on the lower limbs * neuromuscular disorders * restriction in gait capabilities * current medical treatment
epic us feasibility study: use of the fibernet® emboli protection device in carotid artery stenting

Conditions: Carotid Artery Stenosis

Summary: multicenter, prospective, feasibility study designed to demonstrate the performance and safety of the lumen biomedical, inc. fibernet™ embolic protection system as an adjunctive device during carotid artery percutaneous intervention using the guidant acculink carotid stent in high surgical risk patients.


Eligibility criteria:
inclusion criteria: * one or more of the high surgical risk criteria. * candidate for percutaneous stenting with target lesion located within common or internal carotid artery. * symptomatic with atherosclerotic stenosis ≥ 50% or asymptomatic with atherosclerotic stenosis ≥ 70% of the carotid artery by nascet criteria. exclusion criteria: * allergy to heparin. * myocardial infarction within the last 14 days. * angioplasty or ptca/pta procedure within the past 48 hours. * cardiac surgery within the past 60 days. * planned invasive surgical procedure within 30 days. * stroke within the past 14 days. * transient ischemic neurological attack (tia) or amaurosis fugax within the past 48 hours. * intracranial stenosis that exceeded the severity of an extracranial stenosis. * peripheral vascular disease of sufficient severity to prevent vascular access to the target lesion. * total occlusion of the target vessel. * lesion within 2cm of the ostium of the common carotid artery. * a stenosis that is known to be unsuitable for stenting because of one or more of: 1. tortuous or calcified anatomy proximal or distal to the stenosis 2. presence of visual thrombus 3. pseudo occlusion ('string sign') * serial lesions that requires more then one stent to cover entire lesion. * procedural complication prior to introduction of the fibernet device into the body.

Keywords: carotid artery carotid stenosis carotid stenting embolic protection
efficacy of virtual reality reminiscence therapy in nursing home residents with alzheimer's disease or related diseases

Conditions: Virtual Reality; Reminiscence Therapy; Nursing Home; Alzheimer&#39;s Disease or Related Diseases; Crossover Study

Summary: this project provides the easiest possible access to heritage elements that older persons with alzheimer's disease or related diseases knew well but to which they no longer have access due to the motor and functional dependencies they present. it will strengthen the possibilities of reminiscence by using, rather than the usual supports, virtual reality technology to reinforce the immersion effect. it will involve carrying out virtual reality reminiscence workshops intended for residents in nursing home with alzheimer's disease or related diseases and allowing them to explore the heritage of towns and villages in the somme region thanks to these innovative solutions. the aim of this project is to reduce behavioral disorders and improve their quality of life.


Eligibility criteria:
inclusion criteria: * residents of the long-term care facilities of the amiens-picardie university hospital, * residents with mild to moderate alzheimer's disease or related diseases, i.e. with an mmse ≥ 10, * residents or their legal representative agreeing to participate in the study. exclusion criteria: * non-residents of the long-term care facilities of the amiens-picardie university hospital, * residents with an mms \< 10, * residents or their legal representative refusing to participate in the study, * residents in terminal palliative care, * residents with disruptive behavioral disorders.

Keywords: virtual reality reminiscence therapy nursing home alzheimer&#39;s disease or related diseases crossover study
treatment of granuloma umbilical in newborn babies

Conditions: Fetus or Newborn Affected by Condition of Umbilical Cord

Summary: the investigators want to show that steroid creme and even better alcohol swaps are just as effective or equal to the current treatment with silver nitrate of granuloma umbilical in newborns.

the change of treatment will make it possible for parents to treat the children themselves at home, whereas treatment with silver nitrate only is an in hospital regimen.

Eligibility criteria:
inclusion criteria: * gestational age more than 37 weeks * more than 3 weeks old baby * granuloma umbilical diagnosed by a pediatrician * no infections due to the umbilicus * parents do understand and speak danish exclusion criteria: * gestational age less than 37 weeks * less than 3 weeks old baby * granuloma umbilical not diagnosed by a pediatrician * infections due to the umbilicus * parents do not understand or speak danish

Keywords: granuloma umbilical
health management training to enhance influenza vaccine immunogenicity

Conditions: No Conditions

Summary: the goal of this study is to assess the immunogenicity of inactivated influenza vaccination (iiv) in healthy elderly volunteers aged 50 years and older receiving one of two different health management trainings.

we will obtain preliminary data on the time it takes to achieve a protective immune response, durability of response and occurrence of influenza in the following influenza season. promising results in this age group will provide preliminary data for expanded future studies in the elderly.

Eligibility criteria:
general inclusion criteria are the following: * age 50 years or older * infectious disease tests - negative hiv test; hepatitis b surface antigen; anti-hepatitis c virus (hcv) * routine laboratory tests * able and willing to complete the informed consent process * able and willing to participate for the planned duration of the study, including availability for follow-up telephone contact general exclusion criteria * self report of any medical conditions for which the center for disease control (cdc) states should not be vaccinated with iiv * self-reported vaccination with the seasonal influenza vaccine for the current 2010-2011 influenza season (vaccination with the h1n1 influenza vaccine before, during, or after the study will not be exclusionary) * history of hypersensitivity to any influenza vaccine components including thimerosal or egg * history of guillain-barre syndrome * self-reported treatment with immunomodulator/immunosuppressive drugs (interleukins (il), corticosteroids (oral or inhaled)), g(m)- cerebrospinal fluid (csf)) in 4 weeks before enrollment or self reported history of il-2 administration within 5 years * self-reported use of theophylline preparations or warfarin because of the theoretical possibilities of enhanced drug effects and toxicities following influenza vaccination * any clinically significant abnormalities found during a routine physical examination * self-reported history of any autoimmune disease * acute febrile illness on the day of intended immunization - immunization deferred until illness resolved * self report of current alcohol, substance abuse, or systemic/psychiatric illness that potentially could interfere with compliance and ability to make study visits (such as severe attention deficit hyperactivity disorder (adhd) and current major depressive episode)

Keywords: healthy adults aged 50 or older
robotic-assisted gait training combined with transcranial direct current stimulation to maximize gait recovery after stroke

Conditions: Stroke

Summary: 1. study objective to evaluate the effect of robotic-assisted gait training combined with transcranial direct current stimulation (tdcs) as compared to that of robotic-assisted gait training on gait function of chronic stroke patients 2. subjects chronic stroke patients with gait impairment 3. methods * group 1: robotic-assisted gait training with anodal tdcs (45 min) * group 2: robotic-assisted gait training with sham tdcs (45 min) * duration of treatment: 2 weeks, 5 times a week * evaluation: baseline, 1 day after the treatment, 4 weeks after the treatment


Eligibility criteria:
inclusion criteria: * stroke patients who diagnosed by computed tomography or magnetic resonance imaging * hemiplegic patients due to unilateral lesion * patients in chronic stage after 6 months from stroke onset * patients with gait impairment (fac \<= 4) * adult (age \>= 18) exclusion criteria: * unstable vital sign * history of seizure or cranial operation * unable to walk before stroke * bilateral hemispheric lesions * metalic implant (cardiac pacemaker, artificial cochlear, etc.) * severe cognitive deficit, mmse \< 10 * severe aphasic patient who cannot communicate at all

Keywords: stroke transcranial direct current stimulation robotic rehabilitation gait
clinical study of ratg individualized administration in haploidentical hematopoietic stem cell transplantation

Conditions: Hematopoietic Stem Cell Transplantation; Acute Leukemia

Summary: the purpose of this prospective, open-label, pairing design, single-center study is to evaluate the effect of individualized ratg dosing vs traditional weight-based ratg dosing regimen（10mg/kg）for patients with acute leukemia undergoing a myeloablative conditioning regimen and haploidentical hematopoietic stem cell transplantation (haplo-hsct).

allogeneic hematopoietic stem-cell transplantation (hsct) is a potentially curative treatment option for acute leukemia. haploidentical hematopoietic stem cell transplantation (haplo-hsct) has become the main choice for acute leukemia in china. major difficulties of the procedure include graft-versus-host disease (gvhd), graft failure, and relapse. as an important role of haplo-hsct, rabbit anti-thymocyte globulin (ratg), a polyclonal rabbit-derived antibody that depletes lymphocytes, including t cells, was introduced to prevent gvhd and transplant rejection. the recommended dose of ratg in haplo-hsct is 10 mg/kg. however, while the traditional weight-based ratg dosing regimen (10mg/kg) reduces the incidence of gvhd, it increases the risk of delayed immune reconstitution, viral reactivation, and relapse in patients. our previous retrospective study showed that active atg exposure (area under the curve, auc)) post-transplantation is associated with immune reconstitution, gvhd, relapse, survival, and viral reactivation in hsct of acute leukemia patients. identifying the optimal dose of atg to achieve the optimal exposure range of active atg is a pressing clinical issue. the pharmacokinetics of atg varies significantly in both pediatric and adult populations, especially the active atg levels, and clarifying the relationship between the pharmacokinetics of atg and the prognosis of patient outcomes can help in precise treatment. by constructing a population pharmacokinetic model of atg, we can provide an individualized optimal dose of atg based on factors prior to transplantation. atg individualized administration may improve the survival and quality of life of patients undergoing haplo-hsct. a prospective pairing design trial is required to evaluate the effect of individualized ratg dosing vs traditional weight-based ratg dosing regimen (10mg/kg) for patients with acute leukemia undergoing haplo-hsct.

Eligibility criteria:
inclusion criteria: 1. all patients were diagnosed with acute leukemia. 2. all patients should have the indication of haploidentical hematopoietic stem cell transplant and receive the myeloablative conditioning regimen. 3. all patients should sign an informed consent document indicating that they understand the purpose of and procedures required for the study and be willing to participate in the study. exclusion criteria: patients with any conditions not suitable for the trial (investigators' decision).

Keywords: antithymocyte globulin population pharmacokinetic model haploidentical hematopoietic stem cell transplantation acute leukemia