Kornimate/medical-research-clean huggingface dataset:
children's antibiotic resistant infections in low income countries

Conditions: Bacterial Infections

Summary: the main challenge of the charli program is to assess the clinical burden of severe neonatal and childhood bacterial infections in low-income countries,in particular those caused by antibiotic resistant bacteria. this program will address both healthcare associated, as well as community acquired infections. beside its main challenge, the charli program will also allow the assessment of the economic burden of these infections, the improvement of their medical care and then ultimately help to set public health interventions and guide public health measures necessary to combat bacterial infections and bacterial resistance in children. it will also lead to set up more basic research investigation to better understand how pathogenic and epidemic may be the resistant clones in these countries and to experiment innovative strategies devoted to prevent these infections. in order to achieve these objectives, an international paediatric cohort will be created, and monitored a platform. this will be done first within the institut pasteur international network (ipin) and possibly extended in some others low income countries where the ipin has no center. this constituted initiative will represent the first international pediatric program of its size to be located in low-income countries and specifically focusing severe bacterial infections and bacterial resistance to antibiotics


Eligibility criteria:
inclusion criteria: * neonate born to parents living in the study zone of a participating country * parents of the neonate not intending to move away from the study zone during the follow-up period * legal guardians of the neonate informed about the way in which the study is to be carried out and about the collection of biological samples * legal guardians of the neonate having no objection to the collection of biological samples * authorisation from at least one of the legal guardians of the child, in the form of a signed informed consent form. exclusion criteria: * stillborn neonate * parents of the neonate living outside the study zone of a participating country * neonate born to parents planning to move away from the study zone of a participating country during the follow-up period * at least one of the legal guardians of the neonate not informed about the study or about the collection of biological samples * at least one of the legal guardians of the neonate opposed to the collection of biological samples. * neonate already participating in another biomedical study.
chronic neuropathic pain after nerve repair hand surgery

Conditions: Peripheral Nerve Injuries

Summary: this study intends to compare the patients with pain with those who underwent same procedure without developing pain. the patients with pain and without pain will be further analyzed in respect to clinical differences, biomarkers and genetical differences.

chronic pain is a well-known complication after surgery, but the prevalence of persistent pain after upper extremity surgery or other trauma affecting the radial, ulnar or the medial nerve, or branches of these nerves such as digital nerves is unknown. the reason that some patients develop persistent neuropathic pain after surgery, while others, who have been through the exact same procedure or trauma, are pain free is still unknown. the underlying mechanisms are still largely unknown. this can lead to different responses to treatment. whenever possible, it is important to identify and address the underlying pain mechanisms in the individual patient in order to design an optimal treatment. the aim of this study was to determine the prevalence and the factors implicated in the development of persistent pain after nerve suture surgery investigating clinical symptoms, standardized clinical examination for neuropathic pain, 92 biomarkers special developed for neuropathic pain, genetics. conditioned pain modulation and cold pressor test is intend to be performed in all the patients. -

Eligibility criteria:
exclusion criteria: * other condition that may confound assessment of pain attributed to posttraumatic upper limb pain, as judged by the investigator * any condition/disease that could interfere with the study measurements, e.g. peripheral vascular disease, diabetes mellitus, polyneuropathy etc as judged by the investigator inclusion criteria: * • female or male subjects \> 18 years of age * provision of written informed consent * be able to understand and comply with the requirements of the study * patients with a history of persistent spontaneous and/or evoked pain (by e.g. touch, movement) interfering with daily activities of at least 3 months duration, associated with upper extremity surgery or other trauma affecting the radial, ulnar, medial or digital nerve * spontaneous or evoked pain upon standardized test (mechanical, movement)\> 50 on a 100 mm vas scale in the group with pain after nerve repair surgery and a group of patients with no pain
dextromethorphan for the treatment of parkinson's disease and similar conditions of the nervous system

Conditions: Neurodegenerative Disease; Parkinson's Disease

Summary: this study is designed to determine whether dextromethorphan, a drug commonly found in cough medicine, is beneficial and safe for the treatment of parkinson's disease and other diseases that might share biochemical abnormalities with parkinson's disease. patients with parkinson's disease are missing the chemical neurotransmitter dopamine. this occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia. rhythmical muscular tremors, rigidity of movement, shuffling footsteps, droopy posture, and a mask-like expression on the face characterize parkinson's disease. researchers believe that dextromethorphan may be able to safely modify psychomotor function of patients with parkinson's disease.

the ability of the putative excitatory amino acid receptor antagonist, dextromethorphan, to modify psychomotor function safely in patients with neurodegenerative disease will be evaluated using a modified double-blind placebo-controlled design. therapeutic activity will be rated at various doses by means of standard motor and cognitive performance scales. safety will be assessed at frequent intervals by clinical observation and laboratory tests.

Eligibility criteria:
parkinson's disease or other neurodegenerative disorders in which excessive stimulation of central glutamatergic pathways is hypothesized. patients must be in good general health and have no history or clinical evidence of significant cardiac (including dysrhythmias), pulmonary, gastrointestinal, renal, hepatic, endocrine, hematological or psychiatric disease. patient must not evidence any disorder which in the opinion of the investigator imposes an unnecessary risk to the patient or compromises the scientific interpretation of the data. individuals of child bearing potential must practice appropriate methods of birth control.

Keywords: dextromethorphan dextrorphan glutamate antagonist parkinson's disease
noninvasive methods in diagnosing coronary heart disease in diabetic patients

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. exercise tests, doppler echocardiographic examination with tissue velocity imaging, stress echocardiography, transthoracic doppler of coronary arteries with coronary flow reserve, and cardiac mri with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. a subpopulation will in addition measure forearm vasodilation(fmd) and cfr before and after 4 months of exercise training.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * age at diagnosis \> 30 years * age at inclusion 40-75 years exclusion criteria: * angina pectoris * coronary angiography/stress-test diagnostic of coronary artery disease last 3 years * previous myocardial infarction, coronary bypass operation/pci or heart failure * clinical indication for stress -testing * active bronchospasm excluding use of adenosine * egfr \< 30 ml/min/m2 * short estimated life expectancy due to cancer, chronic liver/renal diseases
a hybrid effectiveness implementation trial evaluating behavioral treatments for insomnia for socioeconomically disadvantaged adults in primary care

Conditions: Insomnia

Summary: the overall objective of this study is to conduct a randomized effectiveness-implementation trial to test the non-inferiority of tele-brief behavioral treatment for insomnia vs. tele-cognitive-behavioral therapy for insomnia among socioeconomically disadvantaged adults with insomnia in the primary care setting.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * meet clinical diagnostic criteria for insomnia * insomnia severity score \> 10 * eligible to receive care through publicly supported medical assistance, or * identify as race or ethnic minority * has capacity for informed consent exclusion criteria: * untreated, current major depressive disorder * history of bipolar or psychosis * active substance abuse or drug abuse * excessive daytime sleepiness * seizure within the past 1 year * main sleep period outside of 8pm - 11am * regular nightshift work * untreated, previously diagnosed moderate to severe sleep apnea * severe medical condition, which may require hospitalizations over the next 6 months * active suicidal ideation, if elicited passively during screening * pregnant or planning to become pregnant
validation of the apneascan algorithm in sleep disordered breathing

Conditions: Sleep-Disordered Breathing; Heart Failure

Summary: sleep disordered breathing, in which patients my breath deeply, shallowly or stop breathing for periods whilst asleep, is common in heart failure and associated with a poor prognosis. this study aims to validate a novel function available on certain pacemakers which is designed to detect this condition.the investigators hypothesize that apneascan can accurately detect moderate to severe sleep disordered breathing in patients with heart failure as compared against an embletta sleep study. the investigators will also follow up our patients for 2 years to determine whether the severity of sleep disordered breathing as assessed by apneascan correlates with prognosis.

72 patients with heart failure with reduced ejection fraction (hfref) who have been selected to receive an implantable cardioverter-defibrillator (icd) or cardiac resynchronization therapy pacemaker or defibrillator (crt-p/d) will undergo pre-implant assessment with an echocardiogram, b-type natriuretic peptide (bnp) level, 6 minute walk test, minnesota living with heart failure and epworth sleepiness questionnaires. the patients will then have the device implanted. 6 to 8 weeks later the patent will undergo an embletta home sleep study and download of the apneascan data from the device. the mean apnoea-hypopnoea index (ahi) from the apneascan download will be compared with that derived from the sleep study. the patients will also have a repeat 6 minute walk test, echocardiogram and bnp level. 2 years after device implantation, all patients will be followed up to document deaths, hospital admissions, atrial fibrillation (af) burden and appropriate therapies from icd devices.

Eligibility criteria:
inclusion criteria: * heart failure with reduced ejection fraction (ef \< 40%) * due to receive a device with apneascan function * able to give informed consent * ambulatory exclusion criteria: * known sleep disordered breathing on non-invasive ventilation therapy.

Keywords: sleep-disordered breathing sleep apnoea heart failure
assessment of vertical pattern in correlation with third molar inclusion : a 3d cbct analysis

Conditions: Impacted Third Molar Tooth

Summary: the objective is to compare the sagittal and vertical skeletal parameters of patients with an impacted third molar. patients will be analyzed according to their skeletal characteristics: skeletal class (sagittal direction) and facial skeletal typology (vertical direction). the inclusion characteristics of third molars will also be analyzed, to see the links between typology and inclusion. the principal hypothesis is no significant difference in third molar inclusion patterns in relation to skeletal divergence.

the study is a non-interventional (observational) research involving the human person, research on existing data (retrospective study) and samples dealing with dentofacial orthopedics. this study analyzes third molar inclusion patterns in relation with the skeletal characteristics, sagittal and vertical typology. this is a comparative retrospective study of radiographs in three dimensions before any orthodontic treatment. the patients studied are at bacchetti cs stage 5 (adults), and the third molar must be at least at nolla stage 6 of formation. there is no control group but there are subgroups depending of the skeletal characterics.

Eligibility criteria:
inclusion criteria: * cmv stage 5 on lateral radiography (end of growth) * at least one impacted third molar at minimum nolla stage 6 development exclusion criteria: * previous maxillofacial trauma * growing patients * missing permanent tooth or early avulsion * dysplasia * dentofacial deformities * endocrinological pathologies with implications for maxillofacial growth * syndromes * history of maxillofacial or orthognathic surgery * history of orthodontic treatment * incomplete data

Keywords: cone beam ct third molar vertical dimension impacted teeth orthodontic adult skeletal pattern
selective surgical staging for the treatment of endometrial cancer based on intraoperative consultation

Conditions: Endometrial Cancer

Summary: complete pelvic and para-aortic lymphadenectomy performed at the time of primary surgical staging for endometrial cancer increases operative time and surgical morbidity, but appears to be necessary in most high grade and deeply invasive cancers. to date, the mayo clinic approach has not been reproduced, and the investigators propose to validate their algorithm at the university of kentucky utilizing intra-operative consultation (ioc). the preliminary data at the university of kentucky for ioc and endometrial cancer outcomes suggest that the investigators are well-suited to perform this investigation. a surgical approach that is tailored to the patient's cancer biology is rational, supported by the recent literature, and medically compelling since the co-morbidities of many obese, low-risk ec patients put them at significantly increased perioperative risk for complete lymphadenectomy.


Eligibility criteria:
inclusion criteria: * all patients must be surgical candidates for complete hysterectomy and bilateral salpingo-oophorectomy and pelvic and aortic lymphadenectomy. * patients must have a histologically confirmed diagnosis of endometrial cancer and no clinical evidence of extra-uterine disease on preoperative evaluation. * preoperative evaluation to rule-out extra-uterine disease may include ct scan, mri, or ultrasound. preoperative imaging is not mandatory for study enrollment. * patients may have received prior systemic chemotherapy. such therapy must have been completed at least 5 years prior to study entry and the patient has no evidence of disease subsequent to such therapy. patients must not have received neoadjuvant chemotherapy for the present disease. * patients must have gog performance status 0, 1, or 2. * patients must have an estimated survival greater than or equal to 3 months * patients must have signed an approved informed consent and hipaa authorization. exclusion criteria: * patients with clinical evidence of disease beyond the uterus, including presence of suspicious aortic or inguinal nodes on imaging or clinical exam. * patients who have received previous vaginal, pelvic, or abdominal irradiation. * patients who received chemotherapy directed at the present disease. * patients who have circumstances that will not permit completion of this study or the required follow-up. * patients with renal abnormalities, such as pelvic kidney, horseshoe kidney, or renal transplantation, that would require modification of surgical lymph node assessments. * patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer within the last five years. * patients with gog performance grade of 3 or 4.

Keywords: intraoperative consultation
assessment of hematologic parameters before and after bimaxillary orthognathic surgery

Conditions: Surgical Blood Loss

Summary: the purpose of the present study was to compare some hematologic parameters and operation time in patients who underwent esthetic bimaxillary surgery under hypotensive anesthesia.

patients who underwent bimaxillary surgery were prospectively evaluated. patients were divided into groups based on the surgical procedure and sex (predictor variables). hemoglobin, red blood cells, hematocrit, and platelet were the primary outcome variables, operation time was the secondary outcome variable, and the patients' age and weight were the other variables.

Eligibility criteria:
inclusion criteria: * all consecutive patients listed for elective bimaxillary osteotomies for orthognathic correction by one surgical team, and admitted from august 2010 until june 2012. exclusion criteria: * patients who were having single maxillary osteotomies, le fort ii and iii osteotomies, those with general contraindications for extensive surgical intervention, syndromic patients, those with cleft palate, and those with general diseases or hematological disorders.

Keywords: maxillofacial orthognathic surgery hemoglobin red blood cells hematocrit blood platelets body weight operative time age groups gender
tlk286 in combination with doxil in platinum refractory or resistant ovarian cancer

Conditions: Ovarian Neoplasms

Summary: this is a dose-ranging, open-label, phase 1-2a study of tlk286 in combination with doxil in patients with platinum refractory or resistant ovarian cancer.


Eligibility criteria:
inclusion criteria * histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube cancer or primary peritoneal cancer * recurrent epithelial ovarian cancer or persistent disease following primary treatment * at least one, but no more than four, prior platinum-containing chemotherapy regimens * at least one prior taxane-containing regimen exclusion criteria * a history of prior malignancy except for adequately treated carcinoma in situ of the uterine cervix, basal cell or squamous cell skin cancer, or other cancer for which the patient has been disease-free for 2 years * known leptomeningeal metastases or carcinomatous meningitis * have received prior doxil or other liposomal doxorubicin * having received whole pelvis radiation therapy
dysfunctional attention processes in fear of blushing: specificity and changeability

Conditions: Phobia, Social

Summary: blushing is associated with a heightened self-focused attention. in our study we are interested if this self-focused attention can be shown experimentally and if it can be changed by therapy and training. for the experimental part of the study, we want to compare blushing fearful individuals to social anxious participants who are not fearful of blushing and to healthy controls who report to blush either seldom or quite often. in the therapeutical part of our study, we compare an attention training to the standard cognitive behavioral therapy for social anxiety disorder in an intensive group therapy approach.

fear of blushing is a specific syndrome in social anxiety disorder. although attentional biases for social anxiety disorders have often been reported, specific data for fear of blushing are still missing. in this study, dysfunctional attention processes are examined by the use of various questionnaire measures and attention tests (e.g. stroop test, task switching paradigm) comparing fear of blushers, other social phobia patients, healthy volunteers who report to blush seldomly respectively often. the second goal of the study is to examine if these attention processes can be changed by training and therapy. therefore, individuals who fulfill dsm-iv criteria for social anxiety disorder and report fear of blushing as main problem, are treated with attention training and with cbt for social anxiety disorder. therapy will be held in the form of intensive weekend group therapy. differences in outcomes for both therapy types and in changeability of attention processes on objective test data are examined. stability of results are tested up to 6-month and 12-month after post-assessment.

Eligibility criteria:
inclusion criteria: * social anxiety disorder (dsm-iv criteria) and fear of blushing as main complaint * age: 18-70 exclusion criteria: * acute severe depression or bipolar disorder * any disorder of icd group f2 * acute and severe substance misuse * any bodily illness which hinders from study participation

Keywords: social anxiety disorder social phobia fear of blushing attention attention training cognitive behavior therapy
arthroscopic rotator cuff repair with platelet-rich plasma (prp) in medium to large rotator cuff tears

Conditions: Rotator Cuff Tear

Summary: * the purpose of this study is to compare the clinical and anatomical outcomes of rotator cuff repair with platelet-rich plasma (prp) and conventional rotator cuff repair in treatment of medium to large rotator cuff tears. * prp application to arthroscopic rotator cuff repair would accelerate recovery after arthroscopic rotator cuff repair in terms of pain relief, functional outcomes, overall satisfaction, and enhance structural integrity of repaired tendon.


Eligibility criteria:
inclusion criteria: medium to large rotator cuff tear as a determined by clinical examination and mr prior to surgery. exclusion criteria: * previous history of shoulder surgery * acute trauma * chronic dislocation * pyogenic infection * rotator cuff arthropathy with glenohumeral osteoarthritis and superior migration of the humeral head * showed abnormal serological test results * thrombocytopenia (platelets less than 15000 per microliter) * had been received anti-platelet medication * psychiatric problems that precludes informed consent or inability to read or write * other serious problems that preclude participation of the study
determination of new biomarkers of septic arthritis by surface-enhanced laser desorption/ionization time-of-flight (seldi-tof)

Conditions: Acute Arthritis

Summary: septic arthritis is a frequent, potentially disabling and/or life-threatening disease. to diagnose a septic arthritis is a complex procedure, first because of numerous differential diagnoses (such as crystal arthritis), second because of poor sensitivity of initial gram staining (for example after untimely antibiotic therapy). this protocol will use seldi-tof as a tool to analyse joint fluid of patients with various acute, polymorphonuclear-rich arthritis, as to determine specific and sensitive new biomarkers of a septic origin. such biomarkers will allow rapid diagnosis of septic arthritis in the first hours of admission.


Eligibility criteria:
inclusion criteria: * acute arthritis (onset not more than 7 days ago) * joint fluid leukocyte count : more than 2000/mm3, more than 50% polymorphonuclear exclusion criteria: * none (apart from unability to accept inclusion)

Keywords: acute arthritis bacteria crystal arthritis proteomic seldi-tof