Kornimate/medical-research-clean huggingface dataset:
supplementation of eriocitrin in intestinal microbiota

Conditions: Pre Diabetes

Summary: pre-diabetes is characterized by high plasma concentration of glucose and glycated hemoglobin and is the main risk factor for the development of type 2 diabetes. several studies show that the intestinal microbiota is intimately linked to cardio-metabolic factors (type 2 diabetes, insulin resistance) when in situations of dysbiosis. food is a key element for a healthy microbiota, focusing on the consumption of polyphenols that modulate the intestinal environment through its alteration and production of short chain fatty acids, and can thus be a way of reversing situations such as pre- diabetes and insulin resistance. the objective of the study will be to investigate whether chronic supplementation of eriocitrin alters the intestinal microbiota of pre-diabetic and insulin resistant individuals, reversing these situations. this will be done by supplementation of eriocitrin-containing capsules with different dosages in pre-diabetic and insulin resistant individuals. there will be 12 weeks of intervention, with faecal collections, anthropometric and dietary evaluation, and then will be made microbiological analysis to identify the intestinal microbiota and biochemical analysis before and after the intervention. for statistical analysis, normality and homogeneity test (kolmogorov-smirnov and levine test respectively), t-test to compare baseline time between groups and repeated-measures anova (two-way) were used to compare changes within and between groups.

individuals of both sexes between 30 and 60 years of age who present fasting glycemia between 100 mg / dl (5,6 mmol / l) and 125 mg / dl (6,9 mmol / l) 50, or concentration of glycated hemoglobin between 5.7% (39 mmol / mole) and 6.4% (47 mmol / mole) 50, or glycemic concentrations in the oral glucose tolerance test between 140mg / dl (7.8 mmol / l) to 199mg / dl (11.0 mmol / l) 50. the study will also include insulin-resistant individuals: insulin above 25 uu / ml, or who present homa-ir score above 2.7. individuals using supplements (vitamins, bioflavonoids), pregnant women and those who practice intense physical exercise (\> 10h / week) will be excluded from the study. the primary endpoint will be alteration of the microbiota with possible improvement of the glycemic profile, leading to the reversal of pre-diabetes and insulin resistance.

Eligibility criteria:
inclusion criteria: * 30-60 years * increased fasting blood glucose from 6.1 to 7.0 mmol / l or, * decreased glucose tolerance of 7 , 8 to 11.1 mmol / l or, * glycated hemoglobin with values between 5.7 and 6.4% exclusion criteria: * use hypoglycemic, hypolipidemic drugs, * use dietary supplements (vitamins, minerals, bioflavonoids, prebiotics, probiotics or other bioactive compounds), * exercise intensely (more than 10 hours per week) * history of cardiovascular diseases , diabetes mellitus, liver and kidney disease.

Keywords: eriocitrin citrus bioflavonoids flavanone pre-diabetes blood glucose microbiome
study of the safety and effectiveness of collagen cross-linking at an irradiance of 9 mw/cm2 and 18 mw/cm2

Conditions: Keratoconus; Corneal Ectasia

Summary: the primary objective of this study is to determine the effectiveness and safety of corneal collagen cross-linking at irradiance levels of 9 and 18 mw/cm2.


Eligibility criteria:
general inclusion criteria prospective subjects must meet all of the following criteria to be eligible for participation: * 18 years of age or older * signed written informed consent * willingness and ability to comply with schedule for follow-up visits * contact lens removal prior to evaluation and treatment inclusion criteria for progressive keratoconus prospective subjects must meet two of the following criteria: * having a diagnosis of progressive keratoconus: * an increase of ≥ 1.00 d in the steepest keratometry value * an increase of ≥ 1.00 d in astigmatism manifest refraction * a myopic shift (decrease in the spherical equivalent) of ≥ 0.50 d on subjective manifest refraction * presence of central or inferior steepening on the pentacam map. * axial topography consistent with keratoconus * steepest keratometry (kmax) value ≥ 47.00 d inclusion criteria for ectasia prospective subjects must meet the following criteria: * history of having undergone a keratorefractive procedure * meeting two of the following criteria * steepening by topography, either pentacam or humphrey * thinning of cornea * shift in the position of thinnest portion of cornea * change in refraction with increasing myopia * development of myopic astigmatism * development of irregular astigmatism * loss of best spectacle corrected acuity. 6.2 exclusion criteria subjects meeting any of the following criteria will be excluded from this protocol: * eyes classified as either normal, atypical normal, * corneal pachymetry ≤ 350 microns at the thinnest point measured by pentacam in the eye to be treated * a history of chemical injury or delayed epithelial healing in the eye to be treated. * pregnancy (including plan to become pregnant) or lactation during the course of the study * a known sensitivity to study medications * patients with nystagmus or any other condition that would prevent a steady gaze during the treatment * inability to cooperate with diagnostic tests. * patients with a current condition that, in the investigator's opinion, would interfere with or prolong epithelial healing. * taking vitamin c (ascorbic acid) supplements within 1 week of the cross-linking treatment. * patients who are unable to remain supine and tolerate a lid speculum for an extended period of time.

Keywords: keratoconus collagen crosslinking crosslinking ectasia
improving medication adherence in pediatric inflammatory bowel disease

Conditions: Crohn's Disease; Ulcerative Colitis; Indeterminate Colitis; Inflammatory Bowel Disease

Summary: the purpose of the study is to test an online behavioral intervention to improve medication adherence in children diagnosed with inflammatory bowel disease. interested families will be monitored for four weeks to determine how frequently their child's ibd medication is taken. patient's taking less than 90% of medications will be randomized to one of two intervention conditions to complete intervention sessions online. the study consists of 4 online intervention sessions with topics differing by condition and 5 online assessments to complete quality of life questionnaires over a 14 month time frame.

the purpose of the study is to test the efficacy of a telehealth behavioral treatment (tbt) protocol to improve medication adherence in children and adolescents with ibd via a randomized controlled clinical trial. participants in the tbt condition will be compared to those in an education only (eo) condition. in order to examine clinical significance of the intervention, treatment outcomes will include disease severity, hrqol, and health care utilization. this randomized controlled clinical trial for nonadherence to medication randomizes participants to either the tbt or eo intervention condition, with assessments occurring at baseline, post-treatment, and 3-, 6-, and 12-month follow-up. both conditions will participate in a self-guided educational intervention during week 6 of enrollment, with three intervention sessions at weeks 8, 10, and 12. a 4-week run-in phase immediately preceding randomization is utilized to establish participants' baseline adherence. assessments will occur at week 5 (baseline assessment 1), week 14 (post-treatment assessment 2), and 3-, 6-, and 12-month post-treatment follow-up (assessments 3, 4, and 5). intervention topics will differ for each condition; however, the frequency of contact is equivalent across conditions.

Eligibility criteria:
inclusion criteria: * patient is currently seen for care at one of the collaborating research sites: cincinnati children's hospital medical center, connecticut children's medical center, children's hospital of philadelphia, nationwide children's hospital, university of california san francisco benioff children's hospital, or children's mercy hospitals and clinics * patient diagnosed with crohn's disease, ulcerative colitis, or indeterminate colitis * patient age between 11-18 years * patient currently living at home * patient currently prescribed at least one daily oral immunomodulator (e.g., 6-mp/azathioprine) and/or 5-asa (e.g., mesalamine)in pill form * english fluency for patient and parents * inclusion for randomization: \<90% adherence to immunomodulator and/or 5-asa during four week run-in phase exclusion criteria: * diagnosis of pervasive developmental disorder in patient or parent * diagnosis of serious mental illness (e.g., schizophrenia) in patient or parent
neuropsychological testing in patients undergoing transvascular aortic valve implantation

Conditions: Aortic Stenosis

Summary: the purpose of this study is to examine the neuropsychological effects of transvascular aortic valve implantation (tavi). patients undergoing tavi usually suffer from congestive heart failure and low cardiac output which may limit their cognitive abilities. tavi results in significant improvements in cardiac function and therefore may improve cognitive functions. however, tavi may also be associated with stroke and may therefore have a negative impact on cognition. therefore, in this study the investigators wish to perform a battery of standardized neuropsychological tests before and after tavi to test the net effects of tavi on cognitive performance over time. the investigators plan to include all patients planned to have tavi in the study and to test them before, 3,7, 30 and 360 days post tavi with a standardized battery of test.


Eligibility criteria:
inclusion criteria: * all patients with severe aortic stenosis that are candidates for tavi * able to perform the testing * able to sign informed consent exclusion criteria: * language barriers precluding the administration of the testing * existing dementia * existing disease limiting life expectancy to less than 180 days

Keywords: aortic stenosis tavi neuropsychological cognitive candidates for tavi
effects of temporomandibular disorder on masticatory efficiency

Conditions: Temporomandibular Disorder

Summary: temporomandibular disorders (tmd) are defined by pain in the temporomandibular joint (tmj) and related tissues, limitations in the movements of the lower jaw, and tmj noises.1,2 tmd are classified into four groups as temporomandibular joint disorders, masticatory muscle disorders, headache attributed to tmd and associated structures.3,4 of these, masticatory muscle disorders are the most common tmd subtype seen in dental clinics.5-7 in general, two major symptoms are seen associated with masticatory muscle disorders: pain and dysfunction. pain is the vast majority of complaints about masticatory muscle disorders. the other important complaint is dysfunction, which occurs as a limitation in the opening range of the mandible.8 it is known that individuals with experimental muscle pain are slower than healthy individuals when biting hard food and show lower maximum voluntary clenching capacity.9 also, it has been reported that the maximum bite force decreased in patients with temporomandibular disorders.10 these consequences directly affect patients' quality of life. therefore, rehabilitation of limited masticatory functions is one of the important therapeutic goals for tmd patients.11 in tmd patients, masticatory functions can be measured objectively with bite force, bite force endurance, electromyography, and jaw kinematics, etc. another objective method that can be used to determine masticatory functions is the masticatory efficiency test. in the literature, there are few studies that measure masticatory efficiency in tmd patients.12-16 only two of these studies investigated the effect of tmd treatment and used the sieve method to measure masticatory efficiency.15,16 although the sieve method is considered the gold standard, the procedure is complex and time consuming.17,18 to eliminate these disadvantages, masticatory efficiency measurement with two-color chewing gum tests which are simple and do not require special equipment or training can be used. the effect of many different conditions and treatments on masticatory efficiency was evaluated with this method.19 however, to our knowledge, there is no study in the literature evaluating tmd treatment with this method. the aim of this study was to compare the masticatory efficiency with a two-color chewing gum test before and after treatment of the masticatory muscle-related temporomandibular disorder.


Eligibility criteria:
inclusion criteria: presence of muscle-related temporomandibular disorder exclusion criteria: patients under the age of 18, who had a missing tooth (except 3rd molars) or crown-bridge restorations, any intra-articular temporomandibular disorder were excluded from the study.

Keywords: chewing efficiency masticatory efficiency masticatory muscles masticatory performance temporomandibular disorders
buprenorphine dosing interval - 5

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to explore the feasibility of extending the dosing interval of well maintained buprenorphine patients to 48 and 72 hours, leading to eventual 3 times/week dosing.


Eligibility criteria:
inclusion criteria: m/f ages 21-50. opiate dependence according to dsm-iv critera. self-reported use within the last 30 days. agreeable to conditions of study and signed informed consent. exclusion criteria: psychiatric disorder that requires medication therapy. history of seizures. pregnant and/or nursing women. dependence on etoh or benzodiazepines or other sedative-hynotics. acute hepatitis. other medical conditions that deem participation to be unsafe.
effects of fluid balance control in critically ill patients

Conditions: Fluid Shifts; Critical Care

Summary: most icu patients develop a positive fluid balance, mainly during the two first weeks of their stay. the causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute renal failure, post-operative period of major surgical procedures, and simultaneous fluid loading to maintain volemia and acceptable arterial pressure. additionally, the efficacy of fluid loading is frequently suboptimal, in relation to severe hypoalbuminemia and inflammatory capillary leakage. this results usually in a cumulated positive fluid balance of more than 10 litres at the end of the first week of stay. a high number of studies have showed that such a positive fluid balance was an independent factor of worse prognosis in selected populations of icu patients: acute renal failure, acute respiratory distress syndrome (ards), sepsis, post-operative of high risk surgery. however, little is known about the putative causal role of positive fluid balance by itself on outcome. however, in two randomized controlled studies in patients with ards, a strategy of fluid balance control has been demonstrated to reduce time under mechanical ventilation and icu length of stay with no noticeable adverse effects. although avoiding fluid overload is now recommended in ards management, there is no evidence that this approach would be beneficial in a more general population of icu patients (i.e. with sepsis, acute renal failure, mechanical ventilation). in addition, fluid restriction -mainly if applied early could be deleterious in reducing both tissue oxygen delivery and perfusion pressure. there is a place for a prospective study comparing a "conventional" attitude based on liberal fluid management throughout the icu stay with a restrictive approach aiming at controlling fluid balance, at least as soon as the patient circulatory status is stabilized. the latter approach would use a simple algorithm using fluid restriction and diuretics based on daily weighing, a common procedure in the icu, probably more reliable than cumulative measurement of fluid movements in patients whose limits have been underlined.


Eligibility criteria:
inclusion criteria: * patients under mechanical ventilation, admitted for \> 48h and \<72h and no discharge planned for the next 24h exclusion criteria: * age \< 18 years * failure to weigh the patient * multiple trauma * transfer from another icu with a previous stay \> 24h * high probability of withdrawing treatment for ethical purposes within 7 days * pregnancy * patient refusal

Keywords: fluid overload multiple organ failure diuretics fluid restriction body weight
epidemiology and outcome of pediatric traumatic cataract

Conditions: Traumatic Cataract

Summary: this study aims to explore the demography of pediatric traumatic cataract in upper egypt, and report outcomes and complications of traumatic cataract surgery in these children.

ocular trauma is one of the leading causes of acquired unilateral blindness in childhood.1,2 apart from the permanent disability, ocular trauma has a profound impact on both patients and society at different levels, including, but not limited to, psychological trauma, cosmetic disfigurement, socioeconomic costs, and the need for specialized medical care and vocational rehabilitation. traumatic cataract is a common complication of pediatric eye injury. in developing countries, ocular trauma was responsible for up to 45% of childhood cataract. vision loss induced by traumatic cataract is surgically manageable. however, the high risk of postoperative inflammation, posterior capsular opacification (pco), amblyopia, and the associated ocular tissue damage may negatively impact visual outcome. several studies reported visual outcome of pediatric traumatic cataract in different populations. with the sacristy of studies on traumatic cataract in egyptian children, we conducted this retrospective study to report the demographic features, visual outcome, and complications of pediatric traumatic cataract at assiut university hospital, the biggest tertiary referral center in upper egypt.

Eligibility criteria:
inclusion criteria: * all children who have undergone traumatic cataract surgery at assiut university over 1 year period. exclusion criteria: * children with posterior segment injury. * children who did not complete at least 6 months of postoperative follow-up.

Keywords: pediatric ocular trauma posterior chamber intraocular lens
multi-limb dual-task control in parkinson's disease

Conditions: Parkinson Disease

Summary: people with parkinson disease commonly experience difficulty driving, which requires the arms and legs to do different tasks simultaneously. driving difficulties can lead to isolation, depression, loss of independence and mobility, and increased incidence of car accidents. through understanding the impact of parkinson disease on mechanisms underlying attention and multi-limb control, training and rehabilitation programs can better focus on the needs of drivers with parkinson disease. the proposed study aims to address this need by taking measures of simulated driving at one point in time. subjects with pd are tested at a single time point when they are at their "best" point in their day and on another day when they are at their worst and are about to take their next dose of medication. healthy age-matched subjects are not taking anti-parkinson medication so are tested at only one point.


Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of mild to moderate idiopathic pd (hoehn \& yahr stages 1-3), * hold a valid driver's license and drive at least once a week, and * be capable of providing informed consent and complying with study procedures. control group participants will be healthy, neurologically intact individuals, age-matched to within 2 years of the pd subjects. exclusion criteria: * impaired global cognition (i.e., a score of \< 20 on the montreal cognitive assessment (moca) screening tool) * sensory loss in the lower limb as assessed by clinical test of vibration perception at the ankle, * orthopedic, visual, or neurological conditions that would prevent performance of the experimental tasks, * inability to complete and pass the assessment testing, * history of neurological illness such as head trauma, previous stroke, epilepsy, demyelinating disease, or * complicating medical problems such as diabetes.
a study to monitor the adverse events of qdenga vaccine in participants in malaysia

Conditions: Dengue Fever

Summary: the main aim of this study is to collect the number and type of medical problems (adverse events) after vaccination with qdenga in malaysia and to learn more about such medical problems after vaccination. another aim of this study is to collect the number of persons vaccinated with qdenga who need to stay in the hospital because of severe dengue fever. no vaccination will be given as part of this study. the study will only collect data of persons already vaccinated with qdenga who agree to participate.


Eligibility criteria:
inclusion criteria: 1. participants who have received at least one dose of qdenga vaccine in malaysia during the study period. 2. participants or their legally authorized representative (lars) with a functioning phone number. exclusion criteria: no exclusion criteria will be applied for this study.