Kornimate/medical-research-clean huggingface dataset:
concussion in french non-professional handball league : efficiency of a concussion protocol, the white card process

Conditions: Brain Concussion; Cerebral Concussion

Summary: sport related concussion is a major issue for many contact sports, such as rugby, football, hockey and handball. as a response, some federations like world rugby set up a concussion protocol, that starts with the referee having the responsibility to issue a blue card when suspecting a concussed player and thus have him off the field for medical examination. the french handball federation (ffhb) as well as its concussion protocol called "protocole carton blanc", in this study we aim to describe the efficiency of this protocol.

sport related concussion is a major issue for many contact sports, such as rugby, football, hockey and handball. the short, medium and long-term issues of such impact are still debated but some studies have pointed the fact that acute concussion, repetitive concussions, and even "sub-concussive" impacts could major the risk of developing brain diseases and cognitive impairments. as a response, some federations like world rugby set up a concussion protocol, that starts with the referee having the responsibility to issue a blue card when suspecting a concussed player and thus have him off the field for medical examination. the french handball federation (ffhb) as well as its concussion protocol called "protocole carton blanc", in this study we aim to describe the efficiency of this protocol. this study will be an epidemiological descriptive and prospective study with a brief questionnaire sent off to any player, above 18 years old, male or female, that had receive a white card during an official match in the french amateur handball league along two regular season. the results will bring details on how concussion occurs on field and how this protocol is efficient to bring the player to consult a health professional.

Eligibility criteria:
inclusion criteria: * male or female * over 18 years old * who had received a white card during an official game * having an email address registered in the ffhb register exclusion criteria: * any refusal to participate * inability to respond

Keywords: sport-related concussion handball epidemiology
cardiovascular responses to heat waves in the elderly

Conditions: Aging; Hyperthermia

Summary: the purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions

heat waves are lethal and cause a disproportionate number of deaths in the elderly relative to any other age group. it is important to note that such deaths are primarily cardiovascular, not hyperthermia itself, in origin. nevertheless, we know relatively little about the effects of aging on cardiovascular function during actual heat wave-like conditions. the central hypothesis of this work is that the elderly exhibit greater cardiovascular stress during heat wave conditions. aim 1 will test the hypothesis that recognized impairments in thermoregulatory capacity in the elderly will culminate in heightened cardiovascular stress during prolonged exposure to heat wave conditions. comprehensive cardiovascular and thermal responses in the elderly, relative to younger adults, will be evaluated during exposure to two prolonged heat wave conditions: hot and humid (replicating the 1995 chicago heat wave), very hot and dry (replicating the 2018 los angeles heat wave). the expected outcome from this body of work will re-shape our understanding of the consequences of aging on cardiovascular function during heat waves

Eligibility criteria:
inclusion criteria: * healthy male and female individuals * 18-35 years or 65+ years of age * free of any underlying moderate to serious medical conditions exclusion criteria: * known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia. * taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses. * abnormalities detected on routine screening. * individuals who participate in a structured aerobic exercise training program at moderate to high intensities. * current smokers, as well as individuals who regularly smoked within the past 3 years. * body mass index of greater than 30 kg/m\^2 * pregnant individuals

Keywords: aging heat wave cardiovascular
third molar: caries, periodontal disease and quality of life

Conditions: Caries; Periodontal Diseases

Summary: caries and periodontal disease are chronic diseases of the oral cavity. the incidence of caries and periodontal disease can vary depending on the position of the third molar, the aim of this study was to verify possible associations between oral health-related quality of life (qol), periodontal disease, caries lesions and the position of the lower third molar.

caries and periodontal disease are chronic diseases of the oral cavity. the presence of third molar teeth can lead to periodontal disease in the region, and often can lead to injuries and damage to the oral health, having a significant impact on the quality of life. the incidence of caries and periodontal disease can vary depending on the position of the third molar. purpose: the aim of this study was to verify possible associations between oral health-related quality of life (qol), periodontal disease, caries lesions and the position of the lower third molar. materials and methods: the investigators performed a clinical, observational cross-sectional study within 116 patients that were screened attending to evaluate the need for extraction of third molars at of the specialization course of oral and maxillofacial surgery of dental school foundation of university of são paulo (ffo-usp). caries, periodontal disease and quality of life are the outcomes that were evaluated by the main researcher. caries lesions were assessed by visual tactile examination and periodontal disease through two probing sites around third molar, considering the presence of periodontal pathology when at least one periodontal probing depth was greater than 4 mm, and both were evaluated by radiograph diagnostic methods. the assessment of oral health related quality of life by oral health impact profile questionary (ohip-14), applied as an interview. the evaluation of the position of the third molars was made by clinical and panoramic radiographs according to the classification of pell and gregory and winter. data was treated and analyzed according to stata 13.0, software with descriptive and inferential statistics. the level of significance used was 95%. the study had the approval of ethics committee from university of sao paulo dental school (number 280084).

Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) i patients (negative medical history) * with at least one third molar erupted or partially erupted exclusion criteria: * systemically compromised * allergic * pregnants * patients who had the four third molars included * patients who have already undergone the extraction of one of the third molars

Keywords: third molar dental caries periodontal disease quality of life
study of azd9150 and medi4736 (durvalumab) in japanese adult patients with advanced solid malignancies

Conditions: Advanced Solid Malignancies

Summary: this is a phase i, open-label study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of azd9150 monotherapy and azd9150 in combination with durvalumab in japanese patients with advanced solid malignancies.


Eligibility criteria:
key inclusion criteria: * male and female patients must be at least 20 years of age. * has an eastern cooperative oncology group (ecog) ps score of 0 or 1. * has measurable disease, defined as at least 1 lesion that can be accurately measured in at least 1 dimension (longest diameter to be recorded) with a minimum size of 10 mm by computerised tomography (ct) scan, except lymph nodes which must have minimum short axis size of 15 mm (ct scan slice thickness no greater than 5 mm in both cases). * adequate organ and marrow function * female subjects of childbearing potential and male subjects with partners of childbearing potential should ensure use of a highly effective method of birth control as defined in study protocol key exclusion criteria: * spinal cord compression unless asymptomatic and not requiring steroids for at least 4 weeks before the start of study treatment. * patients must have completed any previous cancer-related treatments before enrolment. * has active or prior autoimmune disease within the past 2 years * has active or prior inflammatory bowel disease or primary immunodeficiency * undergone an organ transplant that requires use of immunosuppressive treatment * abnormalities in rhythm, conduction or morphology of resting 12-lead ecg * prior exposure to azd9150 or any other anti pd (l)1 antibody.
bronchoscopy with bronchial biopsies sub-study of: persistence of airway inflammation and remodeling in asthma remission

Conditions: Asthma

Summary: this study aims at determining the patterns of asthma remission, the prevalence of these different patterns and the various factors associated with such remissions and possible recurrences of asthma, in order to determine the mechanisms involved in these processes. we therefore want to document these specificities in studying biopsies of subjects in complete remission of their asthma and those in only symptomatic remission of their asthma, in comparison with mildly symptomatic asthmatic subjects and healthy controls.

primary outcome measures : airway inflammation and remodeling: in bronchial biopsies secondary outcome measures: comparisons of bronchial biopsy features between groups: * bronchial epithelial morphology * bronchial mucosa (smooth muscle, reticular basement membrane, submucosal gland,...)

Eligibility criteria:
inclusion criteria: * in remission of their asthma: absence of respiratory symptoms, no rescue asthma medication need and (for complete remission) an optimal pulmonary function (fev1 \> 90%) and normal pc20 methacholine for more than two years (with no current treatment). * with a proven past history of asthma from medical files (reversible airway obstruction (\> 12% fev1 after bronchodilator or 20% by other means) proven by spirometry, pef measures or methacholine challenge according to current criteria + previous symptoms and asthma medication use), having no more asthma symptoms and not having used asthma medication for more than 2 years. * agree to sign the consent form. * no other condition that could interfere with the study measurements. exclusion criteria: * subjects using inhaled or oral anti-inflammatory agents. * fev1 \< 1.2 l. * unable to adhere to the protocol requirements. * other current respiratory disease * upper or lower respiratory tract infection or use of antibiotics \< 1 month. * use of oral corticosteroids within the last 3 months. * signs or symptoms of progressive or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic or cerebral disease.

Keywords: remission of asthma
taste and smell testing in end stage renal disease

Conditions: Kidney Failure, Chronic; Olfaction Disorders; Taste Disorders; Malnutrition

Summary: malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status. this study will examine the association between impairment in smell and taste and nutritional and functional markers among patients with end stage renal disease, as well as risk factors for smell and taste impairment.

people with advanced chronic kidney disease (ckd) are at risk for malnutrition, which is associated with significantly increased mortality. impairments in olfaction and taste are under-recognized and under-addressed symptoms that affect this population. olfaction and taste influence appetite and nutritional status and represent a unique target for study and intervention. small cross-sectional studies have shown a higher prevalence of olfactory (up to 56%) and taste disturbances (up to 35%) among patients with ckd compared with the general population, but little is known about longitudinal change in olfaction and taste in this population. additionally, there is a lack of understanding about why these sensory disturbances more commonly occur in people with ckd, although there is speculation that uremia may contribute. this information gained from this study will address these gaps in knowledge by studying longitudinal changes in olfaction and taste and their associations with concurrent and future nutritional and functional status. additionally this study will attempt to identify potentially modifiable risk factors associated with olfactory and taste impairment.

Eligibility criteria:
inclusion criteria: * aged 18 or older * end-stage renal disease requiring chronic dialysis exclusion criteria: * known allergy to quinine * presence of a pacemaker or internal defibrillator * pregnancy or breastfeeding
surveillance of effectiveness/safety of artemether-lumefantrine in patients with malaria

Conditions: Malaria

Summary: the purpose of this study is to describe the pediatric and adult patients (u.s. and foreign residents) diagnosed with malaria and treated with artemether-lumefantrine with regard to their demographics, including evaluation of their malaria immune status, treatment effectiveness, prior and concomitant medication use, and the occurrence of adverse events in association with artemether-lumefantrine treatment, based on the information collected in the cdc malaria case surveillance report form.


Eligibility criteria:
inclusion criteria: * any male or female infant, child or adult patient diagnosed with malaria who received artemether-lumefantrine and was reported to the cdc. malaria may be clinically suspected or confirmed (microscopically, and/or by polymerase chain reaction \[pcr\], and/or rapid diagnostic test \[rdt\]). exclusion criteria: * na

Keywords: artemether-lumefantrine demographics malaria
effects of glp-1ra on body weight, metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus

Conditions: Metformin; Obesity, Abdominal; Diabetes Mellitus, Type 2; Abdominal Fat; Non-Alcoholic Fatty Liver Disease; Metabolism Disorder, Glucose; Metabolism Disorder, Lipid

Summary: the purpose of this study is to analyze the effects of glp-1ra on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.

specific research contents: to study the characteristics of glucose and lipid metabolism and fat distribution in overweight/obesity patients with type 2 diabetes mellitus; liraglutide/ semaglutide/ metformin will be applied to patients for one year, and the changes of lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes and the differences among the three groups will be analyzed before and after treatment. the metabolomic changes of overweight/obese patients with type 2 diabetes before and after medication and the differences among the three groups will be analyzed. explore the correlation between visceral fat content, glucose and lipid metabolism, inflammatory factors and other biochemical indicators and metabolomics.

Eligibility criteria:
inclusion criteria: * aged 18-65 years old * bmi≥24kg/㎡, or waist circumference: \> 85cm (for male) or \> 80cm (for female) * has been diagnosed with type 2 diabetes mellitus * good blood glucose control in recent three months: random blood sugar \< 14mmol/l and hba1c 6-9% * not received any drugs affecting glucose and lipid metabolism or weight loss surgery in the past one month exclusion criteria: * abnormal weight gain caused by other endocrine diseases * severe metabolic diseases, such as diabetic ketoacidosis, hypertonic hyperglycemia * type 1 diabetes or other special types of diabetes * used drugs affecting glycolipid metabolism in the past three months * severe bleeding tendency that unable to complete venous blood collection * patients with mri contraindications * severe renal insufficiency or severe liver insufficiency * patients with advanced malignant tumors * serious cardiovascular and cerebrovascular diseases * rheumatic and immune diseases * pregnant and lactating women

Keywords: metformin glucagon-like peptide-1 receptor obesity, abdominal diabetes mellitus, type 2 non-alcoholic fatty liver disease metabolism disorder, glucose
ocular trauma and covid-19 in indonesia

Conditions: Ophthalmological Disorder; Ocular Injury; COVID-19

Summary: ocular injuries, a significant contributor to avoidable blindness globally, impact approximately 55 million individuals each year. prompt initial treatment is vital for improving vision, yet the scarcity of skilled eye specialists often results in overcrowding at advanced medical centers. moreover, the covid-19 outbreak has introduced distinct factors into the management of ocular trauma. this research investigated the epidemiology of ocular injuries during the pandemic and offered observations on the distinctive hurdles and trends encountered.


Eligibility criteria:
inclusion criteria: * ocular trauma patients presenting between january 2021 to march 2022 exclusion criteria: * presenting on days outside the inclusion criteria
intermittent fasting (if) has gained recognition as a promising weight loss approach that improves body weight, insulin resistance, and metabolism. while standard diets are common in pcos management, if may address the underlying causes of weight gain and offer additional metabolic benefits

Conditions: Polycystic Ovary Syndrome; Weight Loss; Intermittent Fasting; Medical Nutrition Therapy; Caloric Restriction

Summary: the goal of this clinical trial is to learn if dietary interventions works to improve anthropometric measures in women with pcos. the main questions it aims to answer are: * does intermittent fasting (if) cause loss of body weight, fat and muscle mass? * can if be considered more effective to medical and standart nutrition therapy (sdt)? * what dietary problems do participants have when having if diet? participants will: * follow if, sdt, or no intervention for 8 weeks. * visit the clinic once every 2 weeks for check ups with a total of 5 visits for intervention groups if and std, visit at the beginning, second week and at the end for control group * keep dietary records

it was conducted in individuals who were diagnosed with pcos as a result of clinical, biochemical and ultrasonographic medical evaluation by a gynecologist.

Eligibility criteria:
inclusion criteria: * voluntariness to participate in the study * bmi between 25-35 kg/m2 * women between the ages of 18-45 exclusion criteria: * an endocrine disorder other than polycystic ovary syndrome * chronic liver and kidney disease, * diabetes, * hypertension, * hyperuricemia, * heart failure, * thyroid disease, * pregnant and breastfeeding women, * individuals with psychiatric disorders, * oncological diseases, * women using medication, * those with pacemakers and platinum, * those with special nutritional needs

Keywords: diet pcos if
preoperative administration of heparin as thromboprophylaxis in major thoracic surgery

Conditions: Thromboprophylaxis; Thoracic Surgery

Summary: thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or lmwh for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative administration of heparin as thromboprophylaxis in major thoracic surgery.


Eligibility criteria:
inclusion criteria: * 18-75 years old without any preoperative vtes; * patients undergoing major thoracic surgery (including lobectomy, esophagectomy, and thymectomy). exclusion criteria: * patients with coagulation disorders: preoperative international normalized ratio (inr) \> 1.5, or blood platelet count \< 50x10\^9/l; * patients receiving any therapeutic anticoagulation preoperatively; * patients with severe renal or liver dysfunction.
the benefit of the intervention of clowns in pediatric oncology in the accompaniment of painful acts

Conditions: Pain

Summary: the diagnosis and treatment of childhood cancer involves frequent and repeated painful acts. the pediatric oncology-hematology service of nancy's hospital innovates thanks to the involvement of clowns in the hospital. the effects of the clown's intervention corroborate the results of studies which demonstrate that when painful complaints are increased by an empathetic attitude, they are reduced by half when the child is distracted. the main objective is to assess the impact of the presence or absence of clowns during the performance of a painful act, on pain, in children who have benefited from this act. no clowns during the performance of a painful act, on anxiety, in children who have benefited from this act. the secondary objectives are: * evaluate the impact of the presence or not of clowns during the performance of a painful act, on the anxiety of the parents of the child who benefited from this act. * measure the perception and acceptance of the healthcare team of the presence of clowns 1 time every 3 months. * measure the clowns' perception of their interaction with the child, the parents and the healthcare team once every 3 months. * evaluate the overall impact of the clown intervention during the performance of a painful act in children on the course of the act by a "neutral" person (health manager) once every 3 months.


Eligibility criteria:
inclusion criteria: * child virgin with experience for targeted acts during the 1st painful act or child undergoing follow-up provided that he is virgin with experience of the presence of clowns during these acts. * child with cancer * child requiring a painful act among the following 3 acts: lumbar puncture, myelogram, needle placement in an implantable chamber * parental authority holder (s) who have received full information on the organization of the research and who have given their written consent for the participation of their child * personal adhesion of the child with a view to his participation * presence of at least one of the two parents during act 1 * availability of the duo of clowns for the realization of act n ° 1 if the group assigned is the group clowns-sans clowns exclusion criteria: * parents / child's refusal of clowns to intervene

Keywords: pain
indocyanine green (icg) and spy imaging for assessment of burn healing

Conditions: Burns

Summary: three patients were recruited for assessment of icg fluorescence in burns.

the early determination of healing potential in indeterminate thickness burns may be difficult to establish by visual inspection alone, even for experienced burn practitioners. this case series explores the use of indocyanine green (icg) fluorescence using portable bedside assessment as a potential tool for early determination of burn depth. three subjects with indeterminate thickness burns had daily perfusion assessment using icg fluorescence assessment using the spy machine (spy®, lifecell corp., nj, usa) in addition to standard burn care. the fluorescence was quantified as a percentage of the perfusion of intact skin, and areas of hypo and hyper-perfusion were indicated. the burn surgeon, blinded to the icg results, made a clinical determination of the need for skin grafting or discharge. the perfusion in areas of differing depth of burn were compared over the entire study period to determine both the magnitude of difference, and the point in the time course of healing when these changes became evident.

Eligibility criteria:
inclusion criteria: * patients with burn less than 15% tbsa exclusion criteria: * none