Kornimate/medical-research-clean huggingface dataset:
health education during ramadan fasting in type 1 diabetes

Conditions: Diabetes Mellitus, Type 1; Fasting

Summary: adult muslims are obliged to start fasting during the month of ramadan. fasting entails refraining from all food, drink, tablets and injections(vitamins \& fluids) between sunrise and sunset; a period which varies by geographical location and season. people with type 1 diabetes are among those who are risky to fast this holy month in the muslim faith and thus are exempted from fasting. yet many patients fast in spite of medical advice and religious exemption and for those patients, healthcare professionals should provide the utmost care and continuous diabetes education. different diabetes education modalities exist like dsme (diabetes self-management education with proven efficacy. one modality is the diabetes conversation map which delivers diabetes education interactively through a series of maps that address different issues in diabetes management and includes a specially designed ramadan map. in this study, two modalities of diabetes focused ramadan education will be compared regarding aiding patients to fast ramadan safely. one modality will be diabetes conversation maps and the other the international diabetes federation education modules.

adult muslims are obliged to start fasting during the month of ramadan. fasting entails refraining from all food, drink, tablets and injections(vitamins \& fluids) between sunrise and sunset; a period which varies by geographical location and season. although exempt, many diabetics refuse to take this concession as they feel psychologically \& spiritually inclined to fast along with other muslims. fasting at ramadan carries a very high risk for people with t1dm. this risk is particularly exacerbated in poorly controlled patients and those with limited access to medical care, hypoglycemic unawareness, unstable glycemic control, or recurrent hospitalizations. structured education interventions have been endorsed by the national institute for health and clinical excellence as important in empowering patients to improve their jour¬ney with diabetes. in a large observational study, patients who fasted during ramadan without attending a structured education session had a fourfold increase in hypoglycae¬mic events, whereas those who attended an education pro¬gramme focusing on ramadan had a significant decrease in hypoglycemic events. conversation map aims to help people with diabetes experience a healthier ramadan. the interactive map covers a number of topics including understanding the risks and complications of fasting and the importance of creating a diabetes management plan during this time.

Eligibility criteria:
inclusion criteria: 1. patients are intending to fast . 2. duration of diabetes is more than 5 years . 3. insulin regimen is basal-bolus . exclusion criteria: 1. acute complications as major events of hypoglycemia or dka during the last 3 months before ramadan . 2. pregnancy . 3. previous stroke, mi, or unstable angina .

Keywords: diabetes mellitustype1;fasting;health education;hypoglycemia
dose reduced dasatinib (70 mg daily) as first-line treatment for newly diagnosed cml-cp

Conditions: Dasatinib; BCR-ABL; Chronic Myeloid Leukemia

Summary: the purpose of this study is to explore the efficacy and safety of dasatinib 70 mg once daily as first line therapy in patients with early chronic phase (cp) chronic myeloid leukemia (cml).

a multicenter, single-arm, prospective, open-label study to detect the efficacy and safety of 70mg dasatinib by measuring rates of major molecular response (mmr) at 12 months in patients with cml-cp in china. approximately 65 patients will be recruited consecutively from the study sites during the enrollment period and will be given dasatinib 70 mg qd. the duration of patient participation will be 12 months.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * diagnosis of ph+ or bcr-abl positive cml-cp within 6 months. * ecog performance of 0-2. * adequate end organ function defined as the following: total bilirubin \<1.5x uln, sgpt \<2.5x uln, creatinine \<1.5x uln. * patients must sign an informed consent form (icf) indicating they are aware of the investigational nature of this study, in keeping with the policies of the hospital exclusion criteria: * history of any tki treatments. * history of pulmonary arterial hypertension and pleural effusion * nyha cardiac class 3-4 heart disease. * cardiac symptoms - patients meeting the following criteria are not eligible unless cleared by a cardiologist: * uncontrolled angina within 12 months. * diagnosed or suspected congenital long qt syndrome. * any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or torsades de pointes). * prolonged qtc interval on pre-entry electrocardiogram (\>450 msec). * patients with active uncontrolled psychiatric disorders including: psychosis, major depression, and bipolar disorders. * women of pregnancy potential must practice an effective method of birth control, unless otherwise instructed, during the course of the study in a manner such that risk of failure is minimized. * pregnant or breast-feeding women are excluded. * patients in late chronic phase (i.e. time from diagnosis to treatment \>12 months), accelerated phase (except as noted in inclusion criteria 2) or blast phase are excluded.

Keywords: dasatinib, cml-cp
peritonitis prevention after insertion of peritoneal dialysis catheter.

Conditions: Peritoneal Dialysis-associated Peritonitis; Peritoneal Dialysis Catheter Infection; Peritoneal Dialysis Complication

Summary: an intraperitoneal implanted catheter is always necessary to perform peritoneal dialysis. catheter insertion has been associated with infectious complication such as exit site infection (esi), tunnel infection and peritonitis. the last one may lead to loss of the technique because the need of catheter removal. most of international guidelines recommends the use of prophylactic antibiotics. different protocols has been used, mostly intravenous single injection before the procedure. for the last 25 years our unit gives a single intraperitoneal dose of cefazolin immediately after the catheter insertion. the aim of this study is compare the effect of a pre- operative iv dose os cefazolin with a post- procedure intraperitoneal single dose administration of the same drug.


Eligibility criteria:
inclusion criteria: subjects suffering from chronic kidney disease, candidates to a intra- peritoneal catheter insertion exclusion criteria: pregnancy; active antibiotic treatment before the procedure; known allergy to cefazolin
reduce bolus injection of bivalirudin

Conditions: Acute Coronary Syndrome

Summary: there are fewer studies on the bleeding risk of the currently administered bivalirudin bolus injection dose and the safety of bivalirudin in patients with ckd. a non-inferiority, randomized, stratified controlled trial study has been conducted to evaluate the non-inferiority and safety of the low dose (80%) bolus injections of bivalirudin in patients with or without ckd.this study will provide a safe, effective and economical anticoagulation strategy.


Eligibility criteria:
inclusion criteria: * 1 age 18 to 80 years old; 2 medically judge to require coronary angiography; 3 patients agree to use bivalirudin 4 patients signe informed consent. exclusion criteria: * 1.cardiogenic shock; 2.thrombolytic therapy administered before randomization or any anticoagulant administered within 48 hours of randomization; 3.active or recent major bleeding or bleeding predisposition; 4.major surgery within 1 month; 5.clinical syndrome suspicious for aortic dissection, pericarditis, or endocarditis; blood pressure higher than 180/110 mm hg; 6.known hemoglobin less than 10 g/dl,platelet count less than 100 × 109/l, aminotransferase level greater than 3 × the upper limit of normal; 7.history of heparin-induced thrombocytopenia; 8.ellergy to any of the study drugs or devices; 9.eregnancy or lactation; 10.any condition making pci unsuitable or that might interfere with study adherence; 11.patient unwilling or unable to provide written informed consent 12. researchers think it is not suitable to participate in this study.

Keywords: bivalirudin bolus injection activated clotting time renal insufficiency
post marketing surveillance study in rehabilitation clinics (cardio, nephro, diabetes, pulmo)

Conditions: Hypertension

Summary: study to obtain long-term data on effects, safety and tolerability in routine medical practice and to investigate the potential of telmisartan to prevent secondary organ damage


Eligibility criteria:
inclusion criteria: * adult patients of both gender aged \>=18 admitted to a hospital due to insufficiently controlled essential hypertension. no additional selection criteria have to be considered. treatment was at the discretion of the physician following the summary of product information for micardis® and micardisplus® exclusion criteria: * not applicable
impacts of opioids on respiratory drive during sleep

Conditions: Opioids; Obstructive Sleep Apnea (OSA)

Summary: the investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.


Eligibility criteria:
inclusion criteria: * healthy controls: apnea hypopnea index (ahi) \< 5 events/hr on in-laboratory psg within 3 months of enrollment * osa group: ahi \> 10 events/hr on in-laboratory psg within 3 months of enrollment; treated or untreated. exclusion criteria: * sleep disordered breathing or respiratory disorders (other than osa in the osa group), such as central sleep apnea (\>50% of respiratory events scored as central), chronic hypoventilation/hypoxemia (awake sao2 \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions. * other sleep disorders: periodic limb movements (periodic limb movement index \> 20/hr), narcolepsy, or parasomnias. * any unstable major medical condition. * medications expected to stimulate or depress respiration (including other opioids taken at home, barbiturates, benzodiazepines, doxapram, almitrine, theophylline, 4-hydroxybutanoic acid). * history of allergy to lidocaine or oxymetazoline. * contraindications for morphine, including: * allergy to morphine or opioids * chronic obstructive pulmonary disease, asthma, or other significant respiratory disorders * kidney or liver dysfunction, as this can affect the metabolism and excretion of morphine, leading to increased risk of toxicity. * women who are pregnant or breastfeeding will be excluded due to potential risks to the fetus or infant. * history of substance abuse, particularly opioid abuse, will be excluded to prevent potential misuse or relapse. * current use of central nervous system depressants. * individuals with gastrointestinal obstruction. constipation is not an exclusion criterion because morphine is only administered for one night. * recent head injury, brain tumors, or other conditions leading to increased intracranial pressure. * unstable heart disease, particularly those with risk factors for or a history of heart rhythm disorders. * epilepsy or a history of seizures, as morphine can lower the seizure threshold. * severe psychiatric conditions, particularly those with a history of psychosis, as opioids can exacerbate these conditions. * medications that interact with morphine, such as selective serotonin reuptake inhibitors (ssris), serotonin-norepinephrine reuptake inhibitors (snris), tricyclic antidepressants (tcas), monoamine oxidase inhibitors (maois), and the atypical antidepressants buproprion and trazodone. * untreated or unstable endocrine disorders like adrenal insufficiency or thyroid dysfunction.
abdominal drainage during appendicectomy - resources down the drain: a retrospective cohort study

Conditions: Appendicitis

Summary: the investigators performed a retrospective review of all patients undergoing appendicectomy from march-november 2018 using the online theatre database and discharge letters. ca was defined as patients with perforated or gangrenous appendicitis on histology. patients were divided into 2 groups; group 1 (g1) included patients with ca who had a drain inserted; group 2 (g2) included patients with ca and no drain.


Eligibility criteria:
inclusion criteria: * all patients over the age of 16 with complicated appendicitis (ca) were included exclusion criteria: * patients with evidence of caecal/ appendicular malignancy were excluded.
pilates in women with chronic low back pain

Conditions: Back Pain, Low

Summary: the purpose of this study is to evaluate the effect of a pilates exercise program (pep) on the flexo-relaxation ratio (frr) of the erector spinae (es) muscle during standing maximal trunk flexion/extension in women with chronic low-back pain (lbp). a secondary goal is to investigate the effect of pep on full trunk flexion rom (tfrom), pain intensity and functional capacity and analyse their relationship with the frr.

purpose: to evaluate the effect of a pilates exercise program (pep) on the flexo-relaxation ratio (frr) of the erector spinae (es) muscle during standing maximal trunk flexion/extension in women with chronic low-back pain (lbp). a secondary goal was to investigate the effect of pep on full trunk flexion rom (tfrom), pain intensity and functional capacity and analyse their relationship with the frr. material and methods: thirty women with chronic lpb were randomly assigned to either pep (eg, n=15) or control group (cg=15). eg followed an 8-week pep while no specific intervention was carried out on the controls. before and after this period all variables were recorded.

Eligibility criteria:
inclusion criteria: * lumbar or lumbosacral pain (with or without radicular pain) for at least six months; * a score higher than 6/50 on the oswestry disability index (odi) * absence of any back treatment for the last three months. exclusion criteria: * body mass index \> 30 kg/m2 * prior surgery of the pelvis, * spinal column or lower extremity * scoliosis; * systemic or degenerative disease * history of neurological diseases or deficits not related to back pain * pregnancy or hypertension.
study to evaluate the safety and efficacy of filgotinib and lanraplenib in adults with lupus membranous nephropathy (lmn)

Conditions: Lupus Membranous Nephropathy

Summary: the primary objective of this study is to evaluate the efficacy of filgotinib and lanraplenib (previously gs-9876) in adults with lupus membranous nephropathy (lmn).


Eligibility criteria:
key inclusion criteria: * kidney biopsy within the 36 months prior to screening with a histologic diagnosis of lmn (international society of nephrology \[isn\] and the renal pathology society \[rps\] 2003 classification of lupus nephritis), either class v alone, or class v in combination with class ii. * urine protein excretion ≥ 1.5 grams per day * estimated glomerular filtration rate (egfr) ≥ 40 mg/min/1.73m\^2 based on the modification of diet in renal disease (mdrd) formulation at screening * no evidence of active or latent tuberculosis (tb) as assessed during screening key exclusion criteria: * prior treatments as follows: * previous treatment with a janus kinase (jak) inhibitor within 3 months of day 1 * use of rituximab or other selective b lymphocyte depleting agents (including experimental agents) within 6 months of day 1. enrollment is permitted if the last dose was given \> 6 months and cd19-positive b cells are detectable at screening. * use of any concomitant prohibited medications as described in the protocol note: other protocol defined inclusion/exclusion criteria may apply.
the influence of the results of surgical treatment in patients with gunshot and mine-explosive wounds on the formation of chronic pain

Conditions: Chronic Pain

Summary: in 82.1% of patients with gunshot and mine-explosive injuries, the pain becomes chronic. the impact of the results of surgical treatment on the processes of chronic pain in this category of patients remains insufficiently studied. therefore, the study of such a factor will be important to improve the results of pain treatment.

the influence of the results of surgical treatment in patients with gunshot and mine-explosive wounds on the formation of chronic pain needs to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics. considering that in 82.1% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in the treatment of such patients.

Eligibility criteria:
inclusion criteria: * the presence of gunshot and mine-explosive injuries exclusion criteria: * absence of gunshot and mine-explosive injuries

Keywords: chronic pain, surgical treatment, wounds
the effect of non-surgical periodontal treatment on bone metabolism in type 2 diabetes and systemically healthy individuals

Conditions: Periodontal Diseases

Summary: in this study, it was concluded that sclerostin and irisin may be alternative markers for evaluating the effectiveness of periodontal treatment and healing of periodontal tissues by affecting bone metabolism.

background: diabetes and periodontitis are chronic inflammatory diseases with similar pathogenesis and clinical and immunological interrelationships. the aim of this study is to determine periodontal clinical parameters and sclerostin, irisin, receptor activator of nuclear factor κb ligand (rankl)/osteoprotegerin (opg), interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α) levels in gingival crevicular fluid (gcf) in individuals with type 2 diabetes and systemically healthy periodontitis and to evaluate the effect of non-surgical periodontal therapy on these clinical parameters and biomarkers. method: within the scope of this study, applying to necmettin erbakan university faculty of dentistry periodontology clinic; a total of 50 individuals, including 25 patients with type 2 diabetes and periodontitis (dmp group) and 25 patients with systemically healthy and periodontitis (ssp group), were included in the study. after recording the clinical periodontal parameters (gingival index (gi), plaque index (pi), probing pocket depth (ppd), clinical attachment level (cal)) of each individual included in the study, gcf samples were obtained and non-surgical periodontal therapy were completed. the individuals were invited to the controls 3 months later and the procedures for clinical periodontal measurements and dos samples collection were repeated. levels of biomarkers in dos samples were determined by elisa (enzyme linked immunosorbent assay) method.

Eligibility criteria:
inclusion criteria: * having at least 20 teeth in the mouth, excluding the third molars, * individuals between the ages of 18-65 * diagnosed as stage 2 or stage 3 periodontitis as a result of periodontal examination * those who do not have predisposing factors (restoration, caries, etc.) exclusion criteria: * smoking or using alcohol, * any periodontal treatment performed in the last 6 months, * being in pregnancy and/or lactation period, * individuals who had received any anti-inflammatory, antibiotic, antioxidant or corticosteroid treatment in the last 6 months and refused to participate in the study were excluded from the study.

Keywords: gingival crevicular fluid irisin periodontitis sclerostin
effects of exercise intervention and confounding factors on type ii diabetic muscles

Conditions: Diabetes and Healthy Control; FTO Gene Expression; Aerobic Exercise Intervention or Home Exercise; Pre-training and Post-training

Summary: the aim of the first year of this three-year plan is to analyze and compare the muscle quality of lower limb muscle (microcirculation, muscle performance and mechanical characteristics) and maximal aerobic exercise capacity in treadmill exercise tests for diabetic and non-diabetic cases. the hypotheses are:1) the muscle quality of lower limb muscle and maximal aerobic exercise capacity are different between participate with diabetic and non-diabetic, 2) the effect of the three-month aerobic exercise intervention or home exercise on the characteristics of the muscle quality are different , and 3) intrinsic factors (such as age, bmi, and hdl) and characteristics of specific fto genes are influenced the training outcomes.

participants with diabetes will attend an 12-week aerobic exercise intervention or home exercise if the exercise test result of the maximum rate of oxygen consumption is fair or poor. assessments will be taken before and after the training program, which including muscle strength, stiffness, quality, microcirculation and exercise capacity. comparisons between the pre-training and post-training condition will be made for each groups. and the assessments also compare with the healthy control group.

Eligibility criteria:
inclusion criteria: * diabetes group: 1) age between 30-70 years of old, 2) type 2 diabetes. * healthy control group: 1) age between 30-70 years of old, 2) without diabetes exclusion criteria: * history of moderate-severe somatic or autonomic neuropathy, cardiovascular disease, preproliferative or proliferative retinopathy, and chronic renal failure * unable to perform the programs or assessments * other systematic diseases

Keywords: diabetes muscle quality aerobic exercise fto gene
effects of a three-month low calorie diet weight loss intervention on knee replacement outcomes

Conditions: Obesity

Summary: total knee replacement (tkr) significantly improves function, pain, and overall quality of life in patients with end-stage arthritis of the knee. however, studies show that obesity increases complications and costs associated with tkr. the american academy of orthopaedic surgeons (aaos) clinical guidelines recommend that patients with a bmi \> 25kg/m2 lose 5% of their body weight prior to surgery. consequently, although it is not clear how to patients or providers achieve weight loss in this population, some providers and hospitals decline to perform tkr in patients with obesity. low calorie meal replacement diets (lcd) are a feasible way to safely promote short-term weight loss of 8-15% at 3-6 months prior to some elective surgeries. this is a pilot efficacy study to test whether a short-term program using a 3-month lcd leads to weight loss and improved patient reported and functional outcomes. 75 patients eligible for knee replacement surgery and willing to undergo non-operative weight management treatment at nyu langone comprehensive obesity center. this study will establish feasibility and weight loss outcomes in preparation for a multicenter effectiveness trial.


Eligibility criteria:
inclusion criteria: * bmi 35-45 kg/m2 * any ethnicity * able to speak, read, and write in english * have knee replacement surgery already planned by the surgeon * plan to undergo knee replacement surgery within 3-6 months post lcd intervention * willing to commute to nyu langone weight management clinic at the start of the dietary intervention, midway through, and end of intervention exclusion criteria: * uncontrolled type 2 diabetes, defined as hba1c \> 9% * if smokes cigarettes, must go through a 6 week cessation program first * type 1 diabetes * whey protein allergies * soy allergies * anyone in whom rapid weight loss is not indicated (e.g., esrd or cirrhosis, metabolic cancer, abnormal 3 times ul liver enzyme labs) * current untreated or uncontrolled eating disorder (e.g., binge eating, bulimia) * rheumatoid arthritis * in case a previous knee replacement surgery was done, the participant should wait at least 1 year from previous date of surgery * undergoing simultaneous bilateral knee replacement * enrolled in a formal weight loss program * taking anti-obesity medications * coexisting psychotic conditions requiring hospitalization or more intense treatment (e.g., bipolar mood disorder, severe depression) * abnormal cbc, and uric acid, must be treated prior to start of intervention * higher than 5.5 mu/l or lower than 0.3 mu/l tsh must be treated prior to start of lcd intervention