Kornimate/medical-research-clean huggingface dataset:
prediction value of the breathid 13c-methacetin breath test for hepatic decompensation

Conditions: Chronic Liver Disease

Summary: the objectives of this study are: * to evaluate the ability of the methacetin breath test (mbt) to detect hepatic decompensation events * to evaluate the relationship between liver biopsy and clinical outcome and show that the mbt has a better predictive ability of clinical outcome than liver biopsy. * to evaluate the ability of the mbt to predict each of the individual liver related complications.

exalenz has previously gathered information in a previous study on patients with chronic liver disease including the methacetin breath test. several years later, the company wishes to investigate this group of subjects and see retrospectively if the breath test was a predictor of complications related to their liver disease.

Eligibility criteria:
inclusion criteria: all subjects that aere enrolled in the previous exalenz trial his-ex-408 or plt-bid-1108 exclusion criteria: none
study of efficacy of induction chemotherapy with gemcitabine and carboplatin for operable non-small-cell lung cancer before surgery

Conditions: Lung Neoplasms

Summary: to study the activity of chemotherapy with gemzar-carboplatin in the preoperative setting for operable stages of non-small-cell lung cancer and to identify novel molecular markers correlated with chemosensitivity and prognosis


Eligibility criteria:
inclusion criteria: * histologically or cytologically proven, newly diagnosed primary bronchogenic non-small cell lung cancer * measurable or evaluable tumour on chest x-ray or ct scan. * no multiple ipsilateral or contralateral parenchymal tumours * stage i(exceptt1n0),ii,iiia disease as shown by pet-ct

Keywords: lung cancer
awareness of chinese national adult lipid treatment guideline (2007) and rate of patients achieving the treatment goal

Conditions: Hyperlipidemia

Summary: this study is designed to survey the awareness rate of chinese national adult lipid treatment guideline (2007) by cardiologists; to survey the control rate of the patients with dyslipidemia in "real world"; and to evaluate the percentage of hyperlipidemia patients who achieved target ldl-c level according to the chinese national adult lipid treatment guideline (2007) following 8-week treatment by crestor® 5mg or 10mg


Eligibility criteria:
inclusion criteria: * diagnosed as dyslipidemia by doctors * having lipids test and record within one months * diagnosed as hypercholesterolemia or mixed dyslipidaemias and has been prescribed crestor® 5mg or 10mg exclusion criteria: * unable or unwilling to provide the inform consent

Keywords: hyperlipidemia chinese national adult lipid treatment guideline (2007) crestor®
microphthalmia, anophthalmia, and coloboma genetic epidemiology in children

Conditions: Microphthalmia; Coloboma; Anophthalmia

Summary: the investigators are inviting families to take part in a research study that will help us better understand the physical characteristics associated with children who have microphthalmia, anophthalmia, and coloboma (mac) and how changes in their dna sequence, called genetic mutations, play a role in the risk of developing mac

this study is focused on gathering data on individuals diagnosed with some of the more common visually threatening congenital eye defects collectively referred to as mac complex; anophthalmia (total absence of the globe), microphthalmia (anomalously small eye in the orbit), and coloboma (failure of the closure of the fetal fissure). our long-term goal is to improve prevention efforts for and clinical management of mac. the objectives of the current study are to 1) better define the mac phenotype and 2) characterize the role of known and newly identified pathogenic genetic variants that confer mac susceptibility. to do this, the investigators are leveraging resources to identify mac cases through the texas birth defects registry (tbdr), texas children's hospital (tch), and through direct referrals from our study partners. the investigators intend to conduct secondary analyses by leveraging the existing collaborative relationship with the new york state newborn screening program (nysnsp). also, the investigators are utilizing the resources of the national institutes of health (nih) clinical center to comprehensively phenotype cases with mac, and the national eye institute (nei) ophthalmic genomics laboratory to identify genetic variants underlying mac phenotypes.

Eligibility criteria:
inclusion criteria: 1. all mac cases 2. parents of the above children. 3. siblings of the above children. 4. english or spanish speaking. exclusion criteria: all subjects who do not meet the inclusion criteria listed above.
study of the efficacy and safety of abametapir lotion administered for the treatment of head lice infestation

Conditions: Head Lice Infestation

Summary: purpose of this study is to evaluate the efficacy of at-home administration of a single application of abametapir lotion 0.74% w/w for the treatment of head lice.


Eligibility criteria:
inclusion criteria: 1. male or female, aged six months of age or older. 2. is in good general health based on medical history. 3. has active head lice infestation at screening as determined by a trained evaluator with the exception of the male head of household who may self-assess as being lice-free. active head lice infestation is defined as at least three live lice for the index subject and at least one live louse for the other household members. 4. the subject and/or their caregiver is physically able and willing to apply the investigational product at home. 5. belongs to a household with an eligible index subject with active head lice infestation. 6. agrees to an examination for head lice and to all visits and procedures throughout the study. 7. has signed an informed consent and/or assent form. exclusion criteria: 1. had treatment (over-the-counter), home remedy or prescription medication) for head lice within 14 days prior to day 0. 2. intends to use any other form of lice treatment from day 0 through the day 14 visit, unless provided as rescue therapy to this protocol. 3. intends to use a lice comb from the day 0 through the day 14 visit unless provided as rescue therapy to this protocol. 4. intends to cut their hair, use hair dye/bleach or have permanent wave hairstyling from day 0 through the day 14 visit. 5. has a household member(s) who is infested with lice but is not willing or not eligible for enrollment. 6. has a condition that, in the opinion of the investigator, may increase the risk to the subject and/or the interpretation of the data. 7. has visible skin/scalp condition(s) that are not attributable to head lice infestation, such as an erythema score that is \>2, blisters, vesicles which, in the opinion of the investigative personnel or sponsor, will interfere with safety and/or efficacy evaluations. 8. has eczema or atopic dermatitis of skin/scalp. 9. has had a prior reaction to nix® or products containing permethrin. 10. receiving systemic or topical medication, which in the opinion of the investigator, may compromise the integrity of the safety and/or efficacy assessments. 11. has received an investigational agent within 30 days prior to day 0. 12. does not have a known household affiliation with the household members (i.e., does not stay in one household consistently, or sleeps at one place for several nights and then at another place or location).

Keywords: head lice hatchtech
x-ray guided facet block in chronic low back pain

Conditions: Back Pain

Summary: review outcome of injection of facet joint in chronic low back pain

low back pain is a common problem that most people may experience. the incidence of low back pain is highest in the third decade and increases with age until the 60-65 year age group. in the usa the prevalence of low back pain is between 15 and 45%. facet joint is the primary cause of pain in 10-15% of young adult patients with chronic low back pain. probable risk factors include genetic factors, age, smoking, heavy physical work, static work postures, lifting, vibration, obesity, and psychosocial factors.(2) other causes of low back pain include muscle and ligament strain, bulging or ruptured disc, arthritis, osteoporosis treatment of chronic low back pain include pharmacological treatment, ,epidural steroid injection ,facet joint block and back surgery the facet joints are a set of plane types of synovial joints between the articular processes of two adjacent vertebrae, the lumbar facet joint is innervated by the medial branch from the posterior ramus of the lumbar spinal nerve. lumbar facet joint injections are performed by various techniques, including fluoroscopic-guided technique indications of diagnostic and therapeutic facet joint interventions 1. average pain levels \> 5 on a scale of 0 to 10. 2. contraindications or inability to undergo physical therapy or inability to tolerate oral medications. complications from facet joint injections in the lumbar spine are rare and mostly related to the needle placement and/or reactions to injected drugs.(3)

Eligibility criteria:
inclusion criteria:1-strong clinical suspicion of the facet syndrome, 2-focal tenderness over the facet joints 3-low back pain with normal radiological findings, 4-post-laminectomy syndrome with no evidence of arachnoiditis or recurrent disc disease, 5-persistent low back pain after lumbar spinal 6- failed conservative treatment, including physical therapy with exercises, chiropractic management, and pharmacologic therapy exclusion criteria: - 1- low back pain with abnormal radiological findings, 2-post-laminectomy syndrome with evidence of arachnoiditis or recurrent disc disease,
diagnostic imaging of vascular malformations using msot and ulm

Conditions: Vascular Malformation; Arteriovenous Malformation; Lymphatic Malformation; Venous Malformations

Summary: this clinical study evaluates the efficacy and accuracy of multispectral optoacoustic tomography (msot) and ultrasound localization microscopy (ulm) for imaging and diagnosing vascular malformations (venous, arteriovenous, lymphatic). the study aims to enhance diagnostic precision and improve treatment planning through advanced non-invasive imaging techniques.

this study aims to investigate whether multispectral optoacoustic tomography (msot) and ultrasound localization microscopy (ulm) can accurately differentiate between lymphatic, venous, and arteriovenous vascular malformations. msot can determine oxygen levels based on the expected low oxygen content in venous blood, high oxygen content in arterial blood, and the absence of oxygen in lymphatic fluid. additionally, ulm, utilizing microbubbles, measures blood flow velocities, which may help identify and distinguish these malformations or their mixed forms. to date, vascular malformations of blood and lymphatic vessels are commonly diagnosed using cross-sectional imaging techniques such as ultrasound, computed tomography (ct), or magnetic resonance imaging (mri). msot introduces a novel, non-invasive diagnostic approach that enables the assessment of oxygenated hemoglobin concentrations and oxygen levels in blood and tissue. previous studies (e.g., msot_ic, msot_pi) demonstrated the capability of msot to visualize muscle perfusion in patients with peripheral arterial disease. moreover, it has successfully identified muscle structures and the clinical severity of duchenne muscular dystrophy by detecting endogenous biomarkers like collagen and lipids. the objective of this study is to utilize msot and ulm as supplementary diagnostic tools to conventional imaging methods to accurately identify and distinguish between venous, arteriovenous, and lymphatic malformations in patients. this approach has the potential to reduce exposure to ionizing radiation from ct scans and minimize the need for resource-intensive mri procedures in the future.

Eligibility criteria:
inclusion criteria: * confirmed vascular malformations (arteriovenous, venous, or lymphatic). * ≥18 years old and able to give their consent exclusion criteria: * no imaging for diagnostic confirmation has been performed or is planned. * lack of written consent * \<18 years old * safety concerns of the study physician (a patient with physical, psychological, or psychiatric conditions that, in the opinion of the study physician, could compromise the patient's safety or the quality of the data, thereby making the patient an unsuitable candidate for the study).

Keywords: vascular malformation venous malformation arteriovenous malformation lymphatic malformation msot ulm
collection of information-rich type 1 diabetes data

Conditions: Type 1 Diabetes

Summary: the aim of this clinical study was to obtain type 1 diabetes data to identify models for glucose prediction and control and to construct a physiological pharmaco-kinetic/pharmaco-dynamic computer model of a type 1 diabetic person.


Eligibility criteria:
inclusion criteria: * diabetes duration \> 5 years * hba1c \< or = 7.2% * csii treated for \> 3 months * capable of being moderately, physically active for 20 minutes exclusion criteria: * symptoms of diabetic late complications except simplex retinopathy * pregnancy or nursing

Keywords: artificial pancreas model predictive control virtual patient
communities fighting covid return to school

Conditions: COVID-19

Summary: san diego state university (sdsu), a designated hispanic-serving institution, is partnering with sweetwater union high school district, an independent public school district serving 90% ethnic minority and a high proportion of socioeconomically disadvantaged students, and other community partners, to generate evidence for effective and feasible covid-19 testing for unvaccinated and medically vulnerable middle school students and staff as part of broader covid mitigation strategies including vaccination to return students back to school safely.

equitable access to coronavirus 2019 (covid-19) screening is important to reduce transmission and maintain in-person learning for middle school communities, particularly in disadvantaged schools. rapid antigen testing, and at-home testing in particular, could offer substantial advantages over onsite testing from a school district's perspective, but it is unknown if engagement in at-home testing can be initiated and sustained. the investigators hypothesized that an at-home covid-19 school testing program would be non-inferior to an onsite school covid-19 testing program with regard to school participation rates and adherence to a weekly screening testing schedule. the study enrolled 3 middle schools within a large, predominantly latinx-serving, independent school district into a noninferiority trial from october 2021 to march 2022. two schools were randomized to onsite and 1 school to at-home covid-19 testing programs. all students and staff were eligible to participate.

Eligibility criteria:
inclusion criteria: * student at a sweetwater union high school district middle school, staff at a sweetwater union high school district middle school exclusion criteria: * \<2 years of age * not a student or staff at a participating sweetwater union high school district middle school
pain treatment in a breast cancer population. pained study.

Conditions: Breast Cancer

Summary: the objectives of this study are: 1) to design and implement the pained system for the evaluation and treatment based on pain neuroscience education (pne) in cancer survivors with sequelae derived from medical treatments; 2) study the effectiveness of the pained system integrated in a multimodal physical recovery program compared to traditional biomedical information. this project aims to first carry out the design and implementation of an e-health system for the evaluation and treatment of pain. a randomized controlled experimental study will be carried out in which 72 breast cancer survivors will be recruited and randomly assigned to three study groups.

people who have suffered cancer often do not find an adequate therapeutic response for the sequelae derived from its treatments. the objectives of this study are: 1) to design and implement the pained system for the evaluation and treatment based on pain neuroscience education (pne) in cancer survivors with sequelae derived from medical treatments; 2) study the effectiveness of the pained system integrated in a multimodal physical recovery program compared to traditional biomedical information. in this regard, there is a shortage of proposals for certain subgroups of patients who demand special attention. this project aims to first carry out the design and implementation of an e-health system for the evaluation and treatment of pain. a randomized controlled experimental study will be carried out in which 72 breast cancer survivors will be recruited and randomly assigned to the three study groups: a) physical recovery program + access to the pained system; b) physical recovery program + traditional biomedical recommendations; c) control group. the evaluation will be carried out at baseline (at the beginning of the study), at 8 weeks (time of completion of the intervention) and at 6 months of follow-up of the patients.

Eligibility criteria:
inclusion criteria: 1. subjects over 18 years of age. 2. having undergone surgery and finished adjuvant treatment (radiotherapy and / or chemotherapy) six months or two years ago. 3. not having active cancer. 4. having pain in the regions related to the tumor area (cervical and / or brachial and / or shoulder), pain ≥ 4 (vas 0 to 10) for\> 4 weeks 5. present musculoskeletal or functional alterations in the previous regions. exclusion criteria: 1. identification by the research team of physical or mental impossibility to carry out the tests of the study. 2. suffering from chronic pain or having suffered a previous trauma to the spine, head, temporomandibular joint or upper extremities.

Keywords: e-health exercise telehealth telerehabilitation pain management cancer
biomarkers predicting response in patients with non-small cell lung cancer previously treated with erlotinib hydrochloride

Conditions: Lung Cancer

Summary: rationale: studying samples of blood in the laboratory from patients receiving erlotinib hydrochloride may help doctors learn more about the effects of erlotinib hydrochloride on cells. it may also help doctors understand how well patients respond to treatment. purpose: this research study is studying biomarkers predicting response in patients with non-small cell lung cancer previously treated with erlotinib hydrochloride.

objectives: * to evaluate whether serum ngal, mmp-9, ngal/mmp-9 complex, and soluble e-cadherin can be utilized as biomarkers to predict response in patients with non-small cell lung cancer treated with erlotinib hydrochloride. outline: serum samples are analyzed for ngal, mmp-9, ngal/mmp-9, and soluble e-cadherin by elisa and luminex assays.

Eligibility criteria:
disease characteristics: * diagnosis of non-small cell lung cancer * received erlotinib hydrochloride on clinical trial ecog-e3503 patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: non-small cell lung cancer
the usefulness of growth differentiation factor 15 (gdf-15) for risk stratification in cardiac surgery

Conditions: Heart Failure; Coronary Artery Disease

Summary: growth determination factor 15 (gdf-15) and high sensitive troponin-t (hstnt) are emerging humoral markers for risk stratification in clinically stable heart failure patients and in patients with stable coronary artery disease. no data are available about the prognostic value of these peptides in relation to mortality and morbidity in patients undergoing cardiac surgery. primary objective of the present study is to test the hypothesis, that gdf-15 is superior to a standard preoperative risk score, the additive euroscore for the prediction of 30 day mortality and postoperative morbidity in patients scheduled for cardiac surgery. secondary objectives are to test the predictive value of hstnt, either alone, or in combination with gdf-15 and if gdf-15 adds additional information to ntprobnp levels and preoperative cerebral oxygen saturation (sco2) levels.

the study will be based on 2 patient cohorts, a group of patients studied during an observation period (2009) and a validation cohort of patients studied in 2008. the 2009 cohort (about 800 patients) will be analyzed to determine the predictive value of gdf-15 for predicting mortality and morbidity. the 2008 cohort (about 1200 patients) will be used to validate these findings. besides conventional morbidity markers, new sensitive markers of organ dysfunction (fabp, ngal, sflt-1, pigf) will also be tested in the 2009 group.

Eligibility criteria:
inclusion criteria: * patients scheduled for cardiac surgery exclusion criteria: * withdrawal of informed consent

Keywords: risk prediction euroscore gdf-15 hstnt cardiac surgery
a prospective evaluation of hemorrhoidal surgery outcome in istanbul

Conditions: Hemorrhoids; Quality of Life; Complication of Treatment; Indication, Unlabeled

Summary: this study aims to evaluate the effect of surgical treatments on the quality of life in hemorrhoidal disease. all available treatment methods will be included in this 1-year cohort which is going to collect data from a big metropol.


Eligibility criteria:
inclusion criteria: * surgical interventions under local and/or general anesthesia * elective or emergency interventions (including thrombectomy) * surgical interventions in operation room or office * any kind of excision, sclerotherapy, ligation, suturation, ablation, mucopexy exclusion criteria: * any accompanying perianal disease (anal fistula, anal fissure, perianal abscess, anal condyloma extending into the anal canal) * previous surgery for hemorrhoids (any intervention other than medical treatment) * previous perianal surgery (internal sphincterotomy, fistula surgery) * pelvic and/or perineal radiotherapy * previous obstetric or perianal injury and/or sphincter repair * previous rectal surgery (distal colectomy for benign or malignant etiology)