Kornimate/medical-research-clean huggingface dataset:
usability of the collaguard adhesion barrier following hysteroscopic adhesiolysis

Conditions: Hysteroscopic Adhesiolysis

Summary: assess the feasibility of collaguard following hysteroscopic adhesiolysis.

intrauterine adhesions following gynaecological surgery is a major complication which may cause a range of severe clinical symptoms in women. iua's can result in menstrual abnormalities, dysmenorrhea and infertility. in pregnancy, adhesions are related to miscarriage, ectopic pregnancy, abnormal placentation, premature labor and delivery and possibly birth defects. collaguard adhesion barrier is a transparent bioresorbable film approved in europe for the prevention of postoperative adhesions in patients undergoing abdomino-pelvic laparotomy or laparoscopy. this study will assess the feasibility of using collaguard adhesion device in hysteroscopic surgery.

Eligibility criteria:
inclusion criteria: * diagnosed with intrauterine adhesions and found eligible for hysteroscopic adhesiolysis * willing to use additional contraception throughout study exclusion criteria: * be pregnant or having a suspected molar pregnancy, lactating, or planning to become pregnant at any time during the study * has suffered or currently suffers from a gynaecological malignancy * has undergone a previous hysteroscopic surgery (such as removal of fibroids)
a product performance evaluation of a novel contact lens for daily disposable use

Conditions: Myopia

Summary: evaluation of the clinical performance of a novel bausch \& lomb daily disposable contact lens when compared to the currently marketed bausch \& lomb soflens® daily disposable contact lenses and the currently marketed johnson and johnson 1-day acuvue moist contact lenses when worn by adapted soft contact lens wearers on a daily disposable basis.


Eligibility criteria:
inclusion criteria: * subjects with va correctable to 0.3 logmar (driving vision) or better in each eye. * subjects must have clear central corneas and be free of any anterior segment disorders. * subjects must be myopic and require lens correction in both eyes. exclusion criteria: * subjects with any systemic disease affecting ocular health. * subjects using any systemic or topical medications that will, in the investigator's opinion, affect ocular physiology or lens performance. * subjects wearing monovision, multifocal or toric contact lenses. * subjects with grade 2 or greater slit lamp findings.
flow proportional pressure support in volunteers

Conditions: Healthy

Summary: flow proportional pressure support (fpps) is a new mode of spontaneous breathing assistance. in patients with increased respiratory resistance the role of fpps in comparison with the pressure support assist breathing mode is still unclear. in this study the investigators evaluate objective and subjective measured data in healthy volunteers with artificial increased resistance and fpps breathing assistance.


Eligibility criteria:
inclusion criteria: * age over 18 years * asa i and ii exclusion criteria: * refusal of written informed consent * chronic respiratory or cardiac diseases

Keywords: resistance flow proportional pressure support pressure support ventilation volunteers assistant breathing breathing comfort and objective breathing data
preservative-free topical anesthetics for post-prk pain

Conditions: Myopia

Summary: the goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step transepithelial prk surgery. the main research questions to answer are: * question 1: are topical anesthetics effective in reducing post-prk pain? * question 2: are short-term topical anesthetics toxic to the cornea? * question 3: how to prevent abuse of topical anesthetics by patients at home? participants were planned to undergo a bilateral single-step transepithelial prk surgery to correct their refractive errors and received a standard post-prk treatment regimen for both eyes. additionally, one eye was offered a preservative-free topical anesthetic as an experimental group and the other eye was offered a preservative-free artificial tear as a control group.

photorefractive keratectomy (prk) is a well-established surface ablation procedure for correction of refractive errors which involves the removal of corneal epithelium in a large diameter usually more than 6 mm followed by stromal ablation. early postoperative pain within the first few days after surgery is one of the commonest complications reported after prk. the classic postoperative treatment includes the prescription of topical antibiotics and frequent preservative-free lubricants to accelerate epithelial healing. the current treatment regimens also includes topical steroids, topical non-steroidal anti-inflammatory drugs (nsaid) and oral nsaid to reduce inflammation and post-prk pain. earlier studies suggested that topical anesthetics in diluted concentrations and fractional doses didn't delay corneal epithelial regeneration after prk but their use didn't gain popularity because of problems with topical formulation, stability and preservation.

Eligibility criteria:
inclusion criteria: patients who are candidate for prk surgery with 1. myopia up to - 6 diopters or myopic astigmatism up to - 4 diopters. 2. corneal thinnest pachymetry of 500 µm 3. residual stromal bed more than 350 µm after epithelial ablation. exclusion criteria: patients with 1. corneal scars or dry eye disease, 2. past ocular surgery, 3. history of contact lens wear, 4. systemic diseases such as diabetes mellitus and autoimmune diseases, 5. history of oral analgesics abuse.

Keywords: post-prk pain preservative-free topical anesthetics single-step prk
ligament reconstruction in an accelerated rehabilitation protocol

Conditions: Osteoarthritis

Summary: the investigators have found that their patients who get earlier rehabilitation following ligament reconstruction and tendon interposition (lrti) surgery with interference screws have experienced better outcomes. the investigators hypothesis is that when formally comparing these patients who are exposed to the rehabilitation protocol earlier compared to later, the investigators will see statistically better outcomes.

osteoarthritis (oa) of the 1st carpometacarpal (cmc) joint is a significant cause of hand pain, dysfunction, disability, and visible deformity. surgery in the form of ligament reconstruction and tendon interposition (lrti)is often indicated when less invasive procedures fail. following lrti procedures, the accepted classic protocol throughout the literature has been to place patients in a thumb-immobilizing spica cast or splint for 4-6 weeks and then begin rehabilitation exercises. following this, a gradual progressive rehabilitation protocol is initiated which usually focuses on thumb range of motion, pinch strength, and hand function. this standard form of rehabilitation has shown improvements in pain, function, and satisfaction. however, because these patients are usually kept immobilized until 4-6 weeks post-operatively in order for the tendon graft to incorporate and become stable, stiffness can develop in the thumb as a result. this leads to more time off work and without full and unrestricted use of the hand. due to their higher pullout strength compared to conventional tendon fixation, the use of interference screws in lrti procedures may allow for earlier initiation of a more accelerated rehabilitation protocol compared to the standard 4-6 weeks of immobilization prior to rehabilitation. over the past year at the investigators center the investigators have begun post-operative mobilization and rehabilitation on the first post-op visit at 10-14 days following lrti with the use of an interference screw. anecdotally, the investigators have found that their patients have regained their range of motion and function earlier and, in some cases, with larger gains compared to their previous patients they had immobilized for 6 weeks before initiating their rehabilitation. the purpose of this study is to compare patients that have been exposed to the early versus standard rehabilitation protocol to see if there is significant improvement in their range of motion, pinch and grip strength, pain levels and function.

Eligibility criteria:
inclusion criteria: * clinical and radiographic diagnosis of 1st cmc oa * failed to improve with conservative modalities * continued pain over the first cmc joint * loss of strength or motion of the thumb that limits activities of daily living exclusion criteria: * rheumatoid arthritis * gout * cervical radiculopathy * previous thumb/1st cmc surgery * post-traumatic arthritis of 1st cmc * carpal tunnel syndrome with motor function impairment * patients with post-traumatic arthritis of their 1st cmc and have dislocation of this joint.
a study to evaluate the human biodistribution and dosimetry of the radionuclide labeled zt-111 in patients with metastatic prostate cancer

Conditions: Prostate Specific Membrane Antigen Positive Metastatic Prostate Cancer

Summary: this study is to evaluate the safety, biodistribution, radiation dosimetry and tumor uptake of the \[131i\]/\[18f\]/\[68ga\]zt-111 in patients with psma positive metastatic prostate cancer.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years old. 2. histologically or cytologically confirmed prostate adenocarcinoma with documented history of ≥1 metastatic lesions indicated by imaging. 3. informed consent must be obtained in writing from the subject, their legally authorized representative, or caregiver. 4. willing and able to comply with all aspects of this study. exclusion criteria: 1. severe hepatic or renal impairment. 2. history of major surgery within the last month. 3. participation in another concurrent clinical trial.

Keywords: psma positive metastatic prostate cancer
joint thoracic oncology research unit of lyon: lung cancers database (ulysse)

Conditions: Lung Cancer

Summary: prospective longitudinal cohort associated to blood collection, pathological samples collection, and radiological and pathological imaging collection.


Eligibility criteria:
inclusion criteria: * patient treated for a thoracic cancer in the lyon university hospital: non-small cell lung cancer, small cell lung cancer, mesothelioma... * diagnosis can be done: * by cytology or pathologic assessment * or by multidisciplinary team meeting decision: * irradiation without morpho-metabolic sampling * treatment without sampling based on non-invasive molecular data exclusion criteria: - refusal to participate for optional blood sampling : * \< 30 kg for blood collection * no blood sampling schedule for care

Keywords: data collection lung cancer
incretin hormones in type-1 diabetes mellitus glycemic response in type-1 diabetes mellitus

Conditions: Type 1 Diabetes

Summary: the purpose of this study is to investigate whether secretion of incretin hormones is intact and to what extent endogenous as well as exogenous glp-1 controls postprandial glucose excursions in patients with type-1 diabetes mellitus.

glp-1 and gip are incretin hormones secreted from specific endocrine celles in the gut. stimulus for secretion is prescence of carbohydrates, fat and protein in the gut. the incretin hormones controls postprandial glucose excursions through stimulation of insulinsecretion as well as inhibition of glucagon and gastric emptying.the effects of glp-1 on insulin secretion and glucagon inhibition are glucose dependent and the risc of hypoglycemia is therefore negligible when the hormone is administered in supra physiological concentrations.furthermore, some animal studies suggest that glp-1 has a trofic effect on the betacells and the hormone has been shown to replenish intracellular stores of insulin. because the main bloodglucose lowering effect of glp-1 has been thought to be due to increased insulin secretion, analouges of the hormone has been developed for the treatment of type-2 diabetes. so far, relatively little is known about the effect of glp-1 in type-1 diabetes.it possible, that glp-1 in combination with insulin (possibly mainly through its effect on glucagon inhibition and gastric emptying) could reduce the need for exogenous insulin with a concomitant reduced risc of hypoglycemia. without compromising the target glucemic control. this study focuses of the postprandial bloodglucose lowering effects of endogenous as well as exogenous glp-1 in patients with type-1 diabetes according to residual betacell function and glycemic control.furthermore, the endogenous secretion of incretin hormones in patients with type-1 diabetes mellitus will be compared to that of matched normal controls.

Eligibility criteria:
inclusion criteria: * type-1 diabetes mellitus * diagnosis between 5-40 years. * age 18-60 year * normal weight at time of diagnosis * insulintreatment from diagnosis * hba1c \< 7.6 % exclusion criteria: * diabetic complications * disease other than type-1 diabetes

Keywords: glp-1 type 1 diabetes glycemic control incretin hormone
life after cancer: behavioral treatment study to improve quality of life

Conditions: Colorectal Cancer

Summary: the purpose of the study is to find new ways to improve the quality of life of people who have been treated for colon or rectal cancer.

individuals who take part in the study can expect: two interviews: * to be interviewed by our research staff over the phone. the interviews will include questions about your current quality of life and health. brief writing in a journal: * to write for 15 minutes twice a week for two weeks about aspects of your life.

Eligibility criteria:
inclusion criteria: * treated for stage i, ii or iii colon or rectal cancer in the past 5 years * completed surgical treatment * must be able to read and write in english exclusion criteria: * history of other cancers, with the exception of non-melanoma skin cancer

Keywords: colorectal cancer colon cancer rectal cancer
a study evaluating botulinum toxin type a in subjects with postherpetic neuralgia

Conditions: Postherpetic Neuralgia

Summary: 4-month study including a 30-day baseline phase


Eligibility criteria:
inclusion criteria: * postherpetic neuralgia for more than 3 months after the healing of a herpes zoster skin rash. exclusion criteria: * previous use of botulinum toxin of any serotype or immunization to any botulinum toxin serotype.
tai chi chuan as rehabilitation program for mild cognitive impairment in type 2 diabetes mellitus patients

Conditions: Diabetes Mellitus, Type 2; Cognitive Dysfunction

Summary: the patients with type 2 diabetes mellitus (t2dm) is expected to rise to 439 million in 2030, accounting for 7.7% the population in the world. there are nearly 10 million t2dm patients with mild cognitive impairment (mci) among people over 65 years old , accounting for about 8% of the people over 65 years old in china. the medical cost for patients with t2dm/mci is 2.5 to 4 times higher than those without t2dm. and t2dm will increase the risk of cognitive impairment, and lead to various complications which will bring serious social and medical economic burden.

it is critically important to identify effective treatments to enhance functional status of t2dm/mci patients. exercise has been shown to be beneficial for t2dm/mci patients. as a chinese traditional mind-body exercise that consists of both physical and mediation components, tai chi chuan has been proved to be helpful in global cognition, memory, executive function and attention of mci, and blood sugar of t2dm. however, the evidence of the effect of tai chi chuan on t2dm/mci patients is limited. the purpose of this study is to explore the effect of tai chi chuan treating t2dm/mci patients in cognitive function, balance, motor and sensation function, blood sugar, biochemistry profile and quality of life.

Eligibility criteria:
inclusion criteria: 1. clinician diagnosis of t2dm; 2. presence of mild cognitive impairment, not demented; 3. age ≥ 60 years old; 4. did not engage in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time); 5. informed consent and voluntary participation. exclusion criteria: 1. cognitive impairment caused by other reasons, taking drugs, poisoning, etc; 2. presence of medical conditions that unable or unsafe to exercise, such as depression symptoms, uncontrolled hypertension/ blood pressure/ blood glucose, nervous system diseases(stroke, parkinson's disease, etc), musculoskeletal system diseases(arthritis, history of hip and/or knee joint replacement, etc), etc; 3. participating in other experiments that influence this study.

Keywords: tai chi chuan cognitive function postural balance
comparison of peng block and fascia iliaca compartment block in the postoperative pain control of hip capsular fracture

Conditions: Hip Fractures

Summary: a prospective cohort study comparing peng block versus iliac fascia block with the aim of evaluating its effectiveness in the peri-surgical analgesia of intracapsular femoral fracture.

hip fractures are a very common clinical situation in elderly patients and are associated with significant morbidity and mortality. in addition, they have a great social and economic impact that in most cases requires definitive surgical treatment. although it is a very common procedure, in proximal femur surgery there is great variability with respect to anesthetic procedures and their subsequent management. subarachnoid anesthesia is the most commonly used for this type of surgery. during the last few years, different locoregional techniques have been described with the aim of improving perioperative analgesia in these patients. some examples are the iliac fascia block, the 3-in-1 block or the femoral nerve block, which allow a lower consumption of opioids and reduce some adverse effects such as postoperative delirium. the peng (pericapsular nerve group) block is a block recently described for pain management in proximal femoral surgery. it is a pure sensory block that was initially described as an analgesic technique for the treatment of acute pain after femoral fracture but has expanded its uses. its target corresponds precisely to the described innervation of the anterior femoral capsule. regarding the other locoregional techniques mentioned above, these consist of non-selective blocks of the femoral, lateral femoral cutaneous and obturator nerves. therefore, although the iliac fascia block is accepted for analgesic control of hip fracture, the peng block is likely to be more effective because of its high selectivity. for this reason, the investigators have decided to conduct a prospective cohort study comparing peng block versus iliac fascia block with the aim of evaluating its effectiveness in the peri-surgical analgesia of intracapsular femoral fracture.

Eligibility criteria:
inclusion criteria: * patients with subcapital, basicervical or transcervical femoral fracture in whom definitive surgical treatment is decided. * patients who are candidates for nerve block plus intradural anesthesia. * patients who agree to participate in the study exclusion criteria: * patients with dementia or cognitive impairment (evn not evaluable) * polytraumatized patient * patient's refusal to participate in the study * patient's refusal to undergo intradural anesthesia or the blockade * patient with sensory or motor deficits prior to surgery. * patient with anticoagulation or antiplatelet therapy at the time of surgery. * hemodynamically unstable patient or patient who becomes unstable during surgery. * patient allergic to the local anesthetic. * patient with chronic pain in treatment * patient with capital femur fracture

Keywords: subcapital hip fracture peng fascia iliaca compartment block postoperative pain
aminoglycosides in early sepsis

Conditions: Sepsis

Summary: norwegian guidelines for empirical antibiotic therapy in suspected community acquired sepsis recommend the combination of narrow spectrum betalactam and aminoglycoside as the first choice, but broad spectrum betalactams are considered equally appropriate, effective, and safe. however, fear of renal complications due to gentamicin and concern for lacking evidence for efficiency commonly leads to the use of broad spectrum betalactam therapy, a larger driver of antibiotic resistance. in patients with suspected community acquired sepsis, the investigators hypothesize that empirical combination therapy with narrow spectrum betalactams and aminoglycosides is safe and non-inferior to empirical therapy with broad spectrum betalactams. more specifically, the investigators hypothesize that the proportion of patients with acute kidney injury or death will be similar between these two treatment groups. furthermore, the investigators hypothesize that the aminoglycoside-based regimen has lesser impact on the gut microbiome. antimicrobial resistance is one of the most urgent health threats of our time, and norwegian hospitals were required but failed to reduce the use of broad-spectrum antibiotics with 30% by the end of 2020. in this context, novel initiatives aiming at reducing use of antibiotics are direly needed.


Eligibility criteria:
inclusion criteria: * hospitalized * adults 18 year or older * clinical suspicion of community acquired sepsis with indication for empirical antibiotic therapy * national early warning score 2 (news2) ≥ 5 * signed informed consent must be obtained and documented according to ich gcp, and national/local regulations exclusion criteria: * established chronic kidney failure (egfr \< 30 ml/min/1.73m2) * presentation with septic shock with multiorgan failure * suspicion of condition necessitating specific antimicrobial therapy (e.g. atypical pneumonia, fungal infection, parasitic infection, mycobacterial infection) * recent use of nephrotoxic drugs (e.g. cisplatin) * suspected or confirmed carrier of extended spectrum betalactamase (esbl) producing bacteria * multiple myeloma * renal transplantation * myasthenia gravis * known hypersensitivity to any of the study drugs * pregnancy * any condition where gentamicin in the opinion of the investigator poses an unacceptable risk

Keywords: sepsis antibiotics aminoglycosides cephalosporins