Kornimate/medical-research-clean huggingface dataset:
effects of physical activity on the brain in impaired glucose tolerance (igt)

Conditions: Impaired Glucose Tolerance

Summary: the researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.

the age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as alzheimer's disease are a growing public-health concern with devastating effects. referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. to test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.

Eligibility criteria:
inclusion criteria: * subjects with impaired glucose tolerance * 50-65 years old * moderate to heavy weight (bmi 25-35) * must be able to do exercise intervention exclusion criteria: * diabetes * younger than 50 years * bmi \< 25 * psychiatric medication * severe disease * mmse \< 26 * severe cardiovascular disorders

Keywords: exercise elderly cognition prevention cognitive decline lifestyle
comparative trial of home-based palliative care

Conditions: Cancer; Chronic Obstructive Pulmonary Disease; Heart Failure; Dementia; End Stage Liver Disease; End Stage Renal Disease; Neuromuscular Diseases

Summary: background: to effectively alleviate suffering and improve quality of life for patients with serious illness and their caregivers, palliative care (pc) services must be offered across multiple settings. research is needed to determine how best to optimize home-based palliative care (hbpc) services to meet the needs of individuals with high symptom burden and functional limitations. aim: the investigators will compare a standard hbpc model that includes routine home visits by a nurse and provider with a more efficient tech-supported hbpc model that promotes timely inter-professional team coordination via synchronous video consultation with the provider while the nurse is in the patient's home. the investigators hypothesize that tech-supported hbpc will be as effective as standard hbpc. design: cluster randomized trial. registered nurses (n\~130) will be randomly assigned to the tech-supported or standard hbpc model so that half of the patient-caregiver dyads will receive one of the two models. setting/participants: kaiser permanente (15 southern california and oregon sites). patients (n=10,000) with any serious illness and a prognosis of 1-2 years and their caregivers (n=4,800) methods: patients and caregivers will receive standard pc services: comprehensive needs assessment and care planning, pain and symptom management, education/skills training, medication management, emotional/spiritual support; care coordination, referral to other services, and 24/7 phone assistance. results: primary patient outcomes: symptom improvement at 1 month and days spent at home in the last six months of life; caregiver outcome: perception of preparedness for caregiving. conclusion: should the more efficient tech-supported hbpc model achieves comparable improvements in outcomes that matter most to patients and caregivers, this would have a lasting impact on pc practice and policy.


Eligibility criteria:
patient inclusion criteria: * serious illness with 12-24 month life expectancy * homebound * need for skilled nursing care (only at kp southern california) * english or spanish speakers patient exclusion criteria: - currently receiving hbpc caregiver inclusion criteria: * non-professional family, friend or other caregiver * english or spanish speakers
a pilot study to investigate filiation between primary and secondary lesions in acne patients

Conditions: Acne

Summary: exploratory, international, multi-centre, randomized, investigator blinded study in acne


Eligibility criteria:
inclusion criteria: * male or female subjects aged 18 to 35 years inclusive * subjects with active, moderate acne exclusion criteria: * the subject has a secondary acne form (chloracne, drug-induced acne, etc.) (screening) * the subject has a severity of acne that is not amenable to treatment with cd0271-cd1579 (screening)
controlling coordination after childhood cerebellar cancer, a pilot study

Conditions: Brain Cancer

Summary: posterior fossa tumours (pft) account for 2/3 of childhood brain cancers. they can be highly malignant requiring combined chemotherapy and radiotherapy post-surgery for a \>50% chance of cure. pft frequently involve the cerebellum which is responsible for coordinating movement, balance, emotional control, and links closely to control of affect and executive function. pft survivors show highly variable profiles for cognitive and sensorimotor functioning which are influenced strongly by the severity of the pre-diagnostic or post-surgical brain injury state-of-the-art magnetic resonance imaging (mri) scans can allow to measure a variety of different biological processes in the brain, and the investigators believe that some of these mri measures (called mri biomarkers) have the potential to improve our ability to understand and monitor consequences of the ablative brain surgery and complex mechanisms of motor skills recovery. biomarkers are very important for the development of intervention because 1) they help understand the recuperation process and 2) they allow to effectively assess whether or not a treatment or intervention works. transcranial magnetic stimulation (tms) is a powerful non-invasive neuro-modulatory intervention that has the potential to evaluate the integrity of the nervous tracts from the brain to the hand. it is a procedure that applies magnetic pulses on the surface of the scalp to reach underlying brain tissue. tms has built a reputable status among neuro-rehabilitative research, and there is currently a major effort to translate the positive research findings into clinically useful therapeutic strategies. this study is therefore an important first step towards understanding how potential mri biomarkers and responses to tms relate to motor symptoms in pft young survivors. once completed, this study will allow the investigators to select the most promising mri biomarkers and tms protocols to take forward into future treatment trials. the investigators aim to stimulate the recovery of coordination skills, help the development of targeted therapies, and consequently improve long-term quality of life in children and young people with history of brain tumour. the proposed research intends to prove the feasibility of such brain stimulation and imaging and collect some preliminary measures


Eligibility criteria:
inclusion criteria: * able to undergo mri scan without sedation or general anaesthetic * able to give informed consent. exclusion criteria: * history of seizure * current cancer or post surgery treatment * contraindication to tms or mri * pregnancy

Keywords: motor recovery transcranial magnetic stimulation magnetic resonance imaging paediatric cerebellum posterior fossa tumour
the use of subcutaneous implantable cardiac defibrillators (icds) following extraction of conventional icds

Conditions: Use of Subcutaneous ICDs Following Infection

Summary: implantable cardiac defibrillators (icds) are devices that are put into patients at high risk of sudden cardiac death. they are used to treat life threatening heart rhythm disorders. they have conventionally consisted of a generator sitting under the skin of the chest and leads which pass from veins in the collar bone region to the heart. problems with these devices can necessitate extraction, with the commonest reason being infection. if extraction is required for infection then re-implantation is usually deferred for approximately one week whilst antibiotics are given so that the risk of infection of the new device can be minimised. this has considerable implications for healthcare resources. a new icd has been developed that is entirely subcutaneous with no intravenous element. it is already in clinical use and is positioned remote from conventional icd sites. with no intravenous element there is very little risk of infection in the blood affecting the new device. it is therefore likely to be possible to re-implant these devices immediately after extracting a conventional system. the aim of this research is to assess the outcome in patients re-implanted with this device immediately after conventional icd system extraction. this data will be compared compared to those who have conventional systems re-implanted after the necessary delay.


Eligibility criteria:
inclusion criteria: * patients fulfilling conventional criteria for icd extraction and who require implantation of a further icd without a need for pacing. exclusion criteria: * indication for anti-bradycardia pacing or cardiac resynchronisation therapy * life expectancy \< 1 year * need for intravenous inotropes * pregnancy
efficacy, safety and dose finding trial of topical jaungo application in atopic dermatitis patients

Conditions: Dermatitis, Atopic

Summary: atopic dermatitis is a chronic relapsing eczematous skin disease with increasing prevalence. complementary and alternative medical approaches have been employed to relieve symptoms of atopic dermatitis. we aim to establish basic clinical efficacy and safety data for jaungo in patients with atopic dermatitis.

this study is a randomised, double blind, placebo-controlled, single-centre trial with three parallel arms (trial group 1, trial group 2, and control group). the diagnosis of atopic dermatitis will be made according to the criteria of hanifin and rajka. participants will receive jaungo or a placebo-drug for three weeks. participants in trial group 1 will apply jaungo and placebo to the lesion once a day for three weeks. participants in trial group 2 will apply jaungo to the lesion twice a day for three weeks. participants in control group will apply placebo to the lesion twice a day for three weeks. each participant will be examined for easi (eczema area and severity index), scorad (scoring of atopic dermatitis), tewl (transepidermal water loss) and dlqi (dermatology life quality index) before and after applying medication. the outcomes to evaluate the maintenance of safety are draize score, blood test and expert's opinion.

Eligibility criteria:
inclusion criteria: 1. the diagnosis of ad will be made according to the criteria of hanifin and rajka 2. age: 5 years to 65 years 3. objective scorad ≦40, diagnosis of mild to moderate atopic dermatitis (ad) 4. exoriation≥1, lichenification≥1, dryness≥1 or exoriation+lichenification+dryness≥3 5. participants who able to express intention 6. participants willing to provide written informed consent exclusion criteria: 1. participants have oozing in the lesion 2. users of following medications prior to trial periods ① oral steroids, immunosuppressants and antibiotics within 4 weeks prior to this trial ② topical steroids, immunosuppressants and antibiotics within 2 weeks prior to this trial ③ light therapy within 2 weeks prior to this trial ④ other medications thought to be inappropriate by researchers 3. participants have severe burn or wide wound 4. participants have oozing or ulcer in the lesion 5. allergic reactions to angelica gigas, siebold et zuccarini, sesame oil and lard 6. participants have skin disease except atopic dermatitis 7. participants have severe renal function disease (scr \> 2.0 mg/dl) 8. participants have severe liver function disease (alt, ast, alp ≥ 2.5 × normal limits) 9. participants have uncontrolled chronic diseases 10. pregnancy, lactation 11. participation in another clinical trial within one month of enrolment 12. underlying disease or history of severe disease, abnormal state (paralysis; mental retardation other emotional or mental problems; diseases that can affect the absorption of drugs; no enough time to participate in this trial; visual disturbance and hearing impairment; inability to understand written consent or engage in this study) 13. judgment by experts that the potential subject's participation is inappropriate.
internet based cognitive behavioral therapy in pediatric chronic pancreatitis

Conditions: Chronic Pancreatitis; Acute Recurrent Pancreatitis

Summary: abdominal pain is common in children with chronic and acute recurring pancreatitis (cp, arp), and as they continue into adulthood, the disease progresses with increased pain and greater exposure to opioids. despite the relevancy of early pain self-management for childhood pancreatitis, there have been no studies of non-pharmacological pain intervention in this population. the proposed project will evaluate a web-based cognitive behavioral pain management program delivered to a cohort of well-phenotyped children with cp/arp and some community participants to reduce pain, pain-related disability and enhance hrqol; it will also identify genetic risk factors and clinical and behavioral phenotypic factors associated with treatment response to enable precision medicine approaches.

abdominal pain is present in 81% of children and adolescents with cp and arp. effective treatments that target pain in these children will lessen the risk of opioid exposure and continued pain and disability into adulthood. we plan to recruit a large multicenter sample of 260 children and adolescents (ages 10-19 years) with cp/arp and their parents from insppire 2 (insppire:international study group of pediatric pancreatitis: in search for a cure) centers and pancreatitis community groups (e.g. npf) to evaluate the efficacy of webmap, a web-based cognitive behavioral pain management program (cbt). the study design is a two (group) x three (time point) randomized, controlled, double-blinded trial. participants will be randomly assigned to receive online access to either pain education (webed) or cbt (webmap) over an 8-10 week treatment period. the primary study outcome is abdominal pain symptoms measured at pre-treatment, immediately post-treatment, and at 6-month follow-up. secondary outcomes include pain-related disability, health-related quality of life, depression and anxiety symptoms, and medication use. this project represents a significant advance in pain management for children with cp/arp by evaluating the first ever nonpharmacologic pain intervention in these patients, which may guide future developments in the management of chronic pain associated with cp/arp.

Eligibility criteria:
inclusion criteria: 1. diagnosed with cp or arp 2. ages 10-19 years 3. at least 4 acute pancreatitis flare-ups/attacks in past year, or at least 1 instance of moderate (4/10 pain) pancreatitis/abdominal pain in the past month 4. access to the internet on any web-enabled device exclusion criteria: 1. non-english speaking 2. inability to read at the 5th grade level due to learning problem or developmental delay 3. children with cystic fibrosis who have pancreatic insufficiency at the time of diagnosis 4. patients with shwachman-bodian-diamond syndrome 5. acute recurrent pancreatitis (arp) with no evidence of chronic or persistent pain 6. anticipated surgery (tpiat or other) during study participation

Keywords: adolescent pancreatitis pain internet intervention behavioral intervention
healthcare utilization and economic burden of cardiomyopathy in china

Conditions: Cardiomyopathies; Economic Burden

Summary: cardiomyopathy is the most common inherited cardiovascular disease, showing family aggregation, and it has a huge psychological and economic burden on family members. in this study, the investigators collected clinical information and costs of patients hospitalized with cardiomyopathy and establish a database to evaluate the economic burden of cardiomyopathy.

this study conducted a retrospective survey of hospitalized patients with cardiomyopathy aged ≥18 years in 13 centers in china from march 1, 2017 to march1, 2022. the investigators collected demographic and clinical information as well as healthcare utilization data of patients hospitalized with cardiomyopathy so as to evaluate the economic burden of cardiomyopathy in china.

Eligibility criteria:
inclusion criteria: * hospitalized patients with primary discharge diagnosis meeting one of the following subtypes of cardiomyopathy were enrolled, including hcm, dcm, acm, rcm, left ventricular non-compaction, cardiac amyloidosis, fabry disease, pompe disease, danon disease, and prkag2 cardiac syndrome. exclusion criteria: * none
study on anal human papillomavirus infection and anal intraepithelial neoplasia among men who have sex with men in indonesia, malaysia, and thailand

Conditions: HPV Testing

Summary: objectives 1. to determine the prevalence and incidence of anal hpv infection, including infection with high-risk hpv types, among msm in indonesia, malaysia, and thailand. 2. to study the prevalence and incidence of hgain among these msm. 3. to evaluate risk factors, including hiv status, for anal high-risk hpv infection and hgain among these msm. study population an approximately 75 hiv-positive and 75 hiv-negative msm who attended the study clinic in kuala lumpur, jakarta, and bangkok will be enrolled. the study will also enroll 185 hiv-positive and 95 hiv-negative msm who are previous participants of the msm vct study. there will be approximately 260 hiv-positive and 170 hiv-negative msm in total in this study.

this is a prospective cohort study that will newly enroll approximately 150 msm in kuala lumpur, jakarta, and bangkok and follow them prospectively with a group of 280 msm who are previous participants of a study entitled "multidisciplinary services to enhance hiv testing and linkage to care among msm" (msm vct study) in jakarta, bali, and bangkok. newly enrolled msm will have three study visits at baseline, month 6, and at month 12. msm who are previous participants of the msm vct study will only have one study visit.

Eligibility criteria:
inclusion criteria: 1. male with history of anal sex with men or previous participants of the msm vct study. 2. age 18 years old or older. 3. indonesian or malaysian or thai citizen as identified by the indonesian or malaysian or thai national identification card. 4. willing to provide location or contact information and allow contact. 5. available for follow-up for the planned study duration. 6. understand the study and sign informed consent form. exclusion criteria: 1. history of prior treatment for anal cancer or had anal cytology or high-resolution anoscopy or infrared coagulation within 12 months prior to enrollment or had trichloroacetic acid or podophyllin application of the intraanal area in the past month or evidence of active concurrent intraanal or perianal bacterial or herpes simplex infection. 2. persons who have a history of a medical or psychiatric disorder by investigator's interview and physical examination according to standard practices, that in the judgment of the investigator(s), would interfere with ability to give informed consent.

Keywords: male with history of anal sex with men or previous participants of the msm vct study
estrogen, cytokines and heart failure in women

Conditions: Cardiovascular Diseases; Heart Failure, Congestive; Heart Diseases; Menopause

Summary: to determine the effects of estrogen therapy on postmenopausal women with congestive heart failure.

background: congestive heart failure (chf) is a leading cause of morbidity, mortality, and hospitalization in women. the increase in mortality suggests that postmenopausal estrogen loss may alter the phenotypic expression of chf. because estrogen is a potent in vitro inhibitor of pro-inflammatory cytokines (e.g., tnfa, il-1b, il-6), which are re-expressed by the failing myocardium in patients with chf and are related to an adverse prognosis, the study postulates that estrogen replacement will improve the outcome of postmenopausal women with chf. design narrative: the randomized, double blind study was conducted in 166 postmenopausal women with congestive heart failure due to idiopathic (i.e.nonischemic) dilated cardiomyopathy and nyha class ii or iii symptoms on either combined estrogen and progestin or placebo. women maintained their then current congestive heart failure medications for six months. three outcomes were measured: 1) congestive heart failure severity/functional capacity quantified by maximum oxygen consumption during metabolic stress testing; 2) left and right ventricular remodeling quantified by electron bean ct scan; 3) quality of life assessment by the minnesota living with heart failure and kansas city cardiomyopathy questionnaires. in addition, measurements were made of pro-inflammatory markers, that had been demonstrated to be elevated in congestive heart failure to assess whether hormone replacement therapy reduced them. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
postmenopausal women with nyha class ii or class iii congestive heart failure due to idiopathic dilated cardiomyopathy.
pharmacokinetics of advantage anti-caries varnish

Conditions: Dental Caries

Summary: the study aim is to characterize the kinetics of iodine and fluoride following topical application of a combined pvp-i and naf anti-dental caries varnish in healthy adults.

the study was to characterize serum iodine and fluoride levels over 24 hours after application of a topical dental varnish in healthy adults 23 to 57 years old.

Eligibility criteria:
inclusion criteria: * healthy adults 18 y and older, at least 20 teeth, not taking prescription or otc medications. exclusion criteria: * pregnant, weighed less than 110 pounds, had oral mucositis, ulcerative lesions, sensitivity to shellfish or iodine or fluoride varnish, or had known hypothyroidism, hyperthyroidism, dermatitis herpetiformis, hypocomplementemic vasculitis, nodular thread with heart disease, multi nodular goiter, graves disease, or autoimmune thyroiditis

Keywords: adults povidone iodine sodium fluoride
platelet-rich plasma and hip osteoarthritis

Conditions: Hip Osteoarthritis

Summary: to evaluate the effect of platelet-rich plasma (prp) injection on pain, function and quality of life in patients with hip osteoarthritis.

after being informed about the study and potential risk, all patients giving written informed consent will undergo study entry. each patient received three times intra-articuler injections of prp under ultrasound guidance, and they were administered once a week. baseline: visual analog scale (vas) including movement, rest and night, the western ontario and mcmaster university osteoarthritis index (womac) and sf-36 assessment 1st month: vas, womac and sf-36 assessment 3rd month: vas, womac and sf-36 assessment 6th month: vas, womac and sf-36 assessment

Eligibility criteria:
inclusion criteria: * hip pain vas \> 4 * grade 1 and 2 osteoarthritis according to the kellgren-lawrence classification * no pathologies in the laboratory and coagulation parameters exclusion criteria: * rheumatological disease with hip involvement * systemic active infection * severe cardiovascular disease * malignancy * nsaid usage in the last week * history of hip joint surgery * history of traumatic hip injury * hgb values \< 11 gr/dl * platelets values \< 150.000 / µl * history of bleeding disorder

Keywords: hip osteoarthritis platelet-rich plasma ultrasound guidance