Kornimate/medical-research-clean huggingface dataset:
project protect: protecting nursing homes from infections and hospitalization

Conditions: Hospitalization; Infection

Summary: this is a cluster-randomized trial of nursing homes to assess whether decolonization with routine chlorhexidine bathing and periodic use of nasal antiseptics can reduce hospitalizations associated with infections, antibiotic utilization, and multi-drug resistant organism (mdro) prevalence. the comparator arm will be routine bathing care.


Eligibility criteria:
inclusion criteria nursing homes will be eligible to participate if they meet the following criteria: * licensed nursing home in orange county or southern los angeles county serving adults * minimal use of chlorhexidine bathing\* * minimal use of nasal decolonization\* \*minimal use defined as \<15% of residents receiving at least one chlorhexidine bath or nasal decolonization treatment during their nursing home stay. exclusion criteria nursing homes will not be eligible to participate if they meet the following criteria: * facilities routinely using decolonization * dedicated psychiatric nursing homes * facilities with a resident population with \>=20% combative patients * pediatric facilities note: in any participating nursing home, residents with active end-of-life comfort care only measures are excluded

Keywords: nursing homes health facilities infections readmissions multi-drug resistance antibiotic use
preoperative anxiety and postoperative pain in children

Conditions: Post-Operative Pain; Pre-Operative Anxiety

Summary: we wish to study which method of local injection of analgesic (before or during surgery) is the more effective method to reduce post-operative pain in children. in addition, we wish to study which pre-operative educational intervention is more effective in reducing anxiety in children and their family.


Eligibility criteria:
inclusion criteria: * healthy * asa i - ii * undergoing elective day surgery exclusion criteria: * known coagulation dysfunction * sensitivity to analgesics
impact of modified feeding protocol on neonatal outcomes

Conditions: Preterm; Birth Weight; Feeding Disorder Neonatal

Summary: the goal of this clinical trial is to compare modified feeding protocol and current feeding protocol on neonatal outcomes in preterm infants who born with weight less than 2kg. the main questions it aims to answer are: * is modified feeding protocol will decrease the duration of parenteral nutrition and length of hospital stay? * is modified feeding protocol feasible, efficient, and safe in preterm infants? participants will undergo the modified feeding protocol since birth until discharge.

two group in this study prospective group: intervention group will undergo the modified feeding protocol retrospective group: intervention group will undergo the current feeding protocol both group will have care as routine care to this kind of patients but the differ will be in feeding protocol as initiation rate, advancement rate, human milk fortification rate the outcomes of both group will be compeered to meet the study objectives

Eligibility criteria:
inclusion criteria: * birth weight (\<2000g) * gestational age (\<37 week) exclusion criteria: * metabolic disorders * congenital heart diseases * chronic lung disease * congenital anomalies (can related to feeding) * moderate to severe gerd * necrotizing enterocolitis stage 3 (surgical) * gastrointestinal surgery

Keywords: feeding protocol neonates preterm very low birthweight nicu
acute effects of low temperature exposure on respiratory system

Conditions: Lung Function

Summary: this is a randomized controlled human exposure crossover study. investigators aims to assess the acute effects of low-temperature exposure on respiratory health and the underlying mechanisms.

the investigators will conduct a randomized controlled human exposure crossover study among about 40 healthy young adults in shanghai, china. each subject will be exposed twice: once to the low temperature (15℃) and once to the moderate temperature (22℃) in a chamber for about 2 hours. during the exposure session, each subject will be requested to rest. health examinations will be conducted immediately prior to exposure, during the period of exposure, and after exposure. health examinations include lung function tests and exhaled breath test. investigators plan to collect blood, pharyngeal secretion, exhaled breath condensate and urine samples.

Eligibility criteria:
inclusion criteria: * living in shanghai during the study period; * body mass index \> 18.5 and ≤ 28; * right-handed; * receiving or having received higher education; * with the ability to read and understand chinese smoothly. exclusion criteria: * smoking and alcohol abuse; * current drug and dietary supplements intake; * subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy; * subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension; * subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease; * subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease; * subjects who have a history of major surgery due to the cardiovascular, cerebrovascular, respiratory, or neurological diseases; * subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia; * abnormal spirometry (fev1 and fvc ≤ 75% of predicted and fev1/fvc ≤ 0.65); * subjects with color vision disabilities.

Keywords: low temperature randomized controlled trial lung function
efficacy of warm compress therapy in enhancing tear film quality and reducing postoperative des

Conditions: Dry Eye Syndrome

Summary: dry eye disease (ded) is a multifactorial condition often exacerbated by cataract surgery, leading to discomfort and visual disturbances. meibomian gland dysfunction (mgd), a key cause of ded, contributes to tear film instability, which can be managed with warm compress therapy.

this study aims to evaluate the effectiveness of perioperative warm compress therapy (tpt) in improving tear film stability and reducing dry eye symptoms following cataract surgery. this randomized controlled trial (rct) will involve 54 patients with estimated attrition rate 60 participants aged 50-70 with moderate to severe dry eye symptoms and tear film instability, as indicated by high ocular surface disease index (osdi) scores. participants will be randomly assigned to either an intervention group, receiving warm compress therapy before and after surgery, or a control group receiving standard dry eye treatments for 6 weeks.

Eligibility criteria:
inclusion criteria: * patients aged 30 to 70 years * patients scheduled for cataract surgery (both unilateral and bilateral). * patients with preoperative moderate to severe dry eye symptoms, which will be assessed using the ocular surface disease index (osdi). exclusion criteria: * patients with osdi, indicating severe dry eye disease which suggests severe dry eye disease. these patients might require more intensive treatments beyond warm compress therapy. * patients with systemic diseases (e.g., rheumatoid arthritis, lupus) that affect tear production or who are using medications that severely reduce tear production (e.g., chronic use of antihistamines or systemic corticosteroids). * patients with significant pre-existing corneal pathology (e.g., corneal dystrophies, corneal scars) that could affect the results of cataract surgery or thermal pulsation therapy. * patients with active ocular infections (e.g., conjunctivitis, keratitis) or inflammation at the time of screening or surgery. * patients with a history of previous ocular surgeries (excluding cataract surgery) in the study eye, such as refractive surgery (lasik, prk) or corneal transplants. * patients with a known allergy or contraindication to warm compress therapy or its components.
validation of a scale to evaluate the perception of oral health in patients with schizophrenia

Conditions: Schizophrenia

Summary: apart from objective criteria for the evaluation of oral health (cao, cpi...), there are no scales to evaluate the oral health of patients with schizophrenia. the only scales that do exist are for the population at large, children or the elderly. given the severely deteriorated oral health in these schizophrenic populations, it is important to have a tool to evaluate their perception of the quality of their oral health so as to better orientate prevention programmes. the aim of this study is to validate a tool to measure the perception of oral health in patients with schizophrenia. to do this, patients will be invited to complete a series of self-questionnaires relative to the concept of oral health.


Eligibility criteria:
inclusion criteria: * patients with a diagnosis of schizophrenia according to dsm v * hospitalized patients or outpatients who have been taking an antipsychotic treatment for more than 2 years * patients older than 18 years * patients who have provided oral informed consent to take part in the study exclusion criteria: * patients who are psychiatrically unstable or delusional * subjects on chemotherapy * adults under guardianship * patients without national health insurance cover
prevalence and complications of suture in the ed

Conditions: Suture, Complication

Summary: included patients who had sutured wounds in the ed were asked about complications after suture .

all patients using the emergency room of eps fattouma bourguiba monastir are welcomed by a resident in the suture room. after an inclusion, patients are cared for in the outpatient circuit and the suture will be done in the dedicated box. before discharging the patient, instructions and standardized prescriptions are given to the patient such as standard prescriptions for local wound care, removal of stitches and verification of vaccination status. the data relevant to this study are obtained prospectively from a detailed questionnaire in the annex and a telephone call and they are completed retrospectively with the data collected in the computerized medical record. at the healing period, between 15 days and 45 days after the suture, the investigators called the patients back in order to know the evolution of the wound, the adherence to the instructions and the prescriptions, the quality of healing and the search for complications (infection , loose stitches, hematoma, etc.)

Eligibility criteria:
inclusion criteria: * patients with acute suturable wound exclusion criteria: wounds requiring surgical treatment septic wounds chronic lesions vascular wounds patients who did not consent to the protocol.

Keywords: suture complications
daily adaptive radiotherapy in postoperative hypofractionated salvage radiotherapy for prostate cancer patients

Conditions: Prostate Cancer

Summary: this is a monoinstitutional prospective pilot study, aiming to evaluate treatment-related toxicity of an hypofractionated postoperative salvage radiotherapy with daily-adaptive modality in patients affected by prostate cancer biochemical recurrence. patients will be treated with postoperative hypofractionated salvage radiotherapy with a dose of 59 gy in 20 fractions with daily-adaptive modality. considering the consolidate role and clinical outcome of postoperative hypofractionated radiotherapy with elevate level of evidence (8-10), the study will not be controlled, but compared with literature data.


Eligibility criteria:
inclusion criteria: * age ≤ 80 years; * prostate cancer diagnosis, pt2-3 pn0, any resection margin (r0 or r1); * indication to local salvage treatment defined as: early salvage radiotherapy after primary prostate surgery (radical prostatectomy) with psa \<0.2 ng/ml or salvage radiotherapy after primary prostate surgery (radical prostatectomy) with psa ≥0.2 ng/ml; * no distant metastases (m0) diagnosed with psma-pet-ct; * informed consent to trial's participation and personal data treatment. exclusion criteria: * age \<18 years old; * adjuvant radiotherapy; * previous radiation in the same anatomical site.
open label extension study of nalbuphine hcl er in patients with prurigo nodularis

Conditions: Prurigo Nodularis; Nodularis Prurigo; Prurigo

Summary: the primary objective of the study is to evaluate the overall safety of nalbuphine hcl er tablets during a treatment period of up to 50 weeks.


Eligibility criteria:
inclusion criteria: * subject completed participation in the tr03 study exclusion criteria: * medical condition or other factors that in the opinion of the investigator may interfere with the conduct of the study. * subject is a pregnant or lactating female

Keywords: itch chronic itch nalbupine
clinical comparison of 4 daily disposable soft contact lenses

Conditions: Refractive Error

Summary: the purpose of this study is to obtain on-eye performance data to inform contact lens product development and to further evaluate product performance in the intended population.

the expected duration of subject participation in the study is approximately 20 days with 3 scheduled visits. each subject will evaluate the test contact lenses compared to 1 of 3 commercially available contact lenses.

Eligibility criteria:
inclusion criteria: * able to understand and must sign an approved informed consent form * successfully wears daily disposable spherical soft contact lenses in both eyes for a minimum of 5 days per week and 8 hours per day during the past 3 months * best corrected visual acuity of 20/25 snellen or better in each eye * willing to stop wearing habitual contact lenses for the duration of study participation * other protocol-defined inclusion criteria may apply exclusion criteria: * any eye condition, surgery, disease, or use of medication that contraindicates contact lens wear, as determined by the investigator. * routinely sleeps in habitual contact lenses * currently wears oasys 1-day, myday, or moist contact lenses * other protocol-defined exclusion criteria may apply

Keywords: contact lenses myopia near-sighted daily disposable
expert peer facilitation of the everybody project

Conditions: Body Image; Eating Disorder Symptom

Summary: the third trial of the everybody project explored the efficacy of using expert peer leaders to deliver the two-session, inclusive, group body image intervention compared to a time-matched video and expressive writing group through three-month follow-up. expert peer leaders were college students with lived and/or academic expertise who were screened for facilitation readiness through a two-day training.

the first two trials of the everybody project demonstrated that a gender-inclusive, diversity-focused, dissonance-based group body image intervention could improve eating disorder risk factors among college students, particularly when the two session program was delivered by individuals with expertise (faculty or staff with body image expertise). when peer interventionists were used (college students with body image interest who completed a two-day training before facilitating groups), the effects of the everybody project were diminished. although peer facilitation is commonly used for delivering dissonance-based body image interventions, an open training peer facilitation model (where all students who are trained are eligible to deliver the intervention) may not be the most beneficial for leading inclusivity-focused body image groups. the current trial of the everybody project (trial 3) explores a novel strategy to implement this program using expert peer facilitators. college students with lived or academic expertise in both body image and diversity topics were recruited to complete a two-day training. the training included practice and feedback on the two session intervention content as well as training on inclusive facilitation. following the training, peer leaders completed a facilitation readiness self-evaluation and were evaluated by trainers for facilitation expertise. only students who passed the expertise threshold were invited to facilitate everybody project groups. the expert peer facilitation of the everybody project was compared to a time-matched two session passive video and expressive writing intervention. college students within a university in the pacific northwest united states were invited to participate in the group intervention (universal intervention target, gender inclusive). outcome assessment included a comparison of changes in eating disorder risk factors and symptoms across randomization conditions from pre-post intervention through three-month follow-up. program satisfaction was assessed at post-intervention and program application was assessed post-intervention and at three-month follow-up.

Eligibility criteria:
inclusion criteria: * current college student enrolled at institution where research was taking place exclusion criteria: * none
e-monitoring of patients under adjuvant hormonotherapy for breast cancer.

Conditions: Breast Cancer

Summary: this is a monocentric, prospective cohort study evaluating the feasibility of an e-monitoring protocol in patients with breast cancer treated by adjuvant hormonotherapy . 45 patients will be included. patients will be followed during 6 months.


Eligibility criteria:
inclusion criteria: 1. patient treated for hormone-dependent localized breast cancer with adjuvant ht (tamoxifen or anti-aromatase +/- lhrh agonist) 2. patient equipped with a computer or tablet computer and an internet connection at home 3. age \> 18 years old 4. patient affiliated to the french social security system 5. patient who has signed informed consent before inclusion in the study and before any specific procedures for the study 6. women of childbearing age should have effective contraception under hormonotherapy exclusion criteria: 1. patient with breast cancer who does not require adjuvant hormonotherapy 2. patient with metastatic breast cancer 3. any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure 4. patient previously treated for breast cancer (infiltrating or in-situ) with adjuvant ht or not 5. patient protected by law.

Keywords: breast cancer hormonotherapy e-monitoring
impact of phenylketonuria-type diet on appetite, appetite hormones and diet induced thermogenesis

Conditions: Phenylketonuria (PKU)

Summary: low-phenylalanine diets are commonly prescribed to people with phenylketonuria (pku), an inborn disease which causes accumulation of amino acid phenylalanine (phe) in the blood. high blood phe levels can cause mental, behavioural, neurological, and physical problems. thus, low-phenylalanine diets help patients to manage their condition but it is not clear whether they have an impact on appetite, energy intake and changes in body weight. this is important to explore as prevalence of obesity in this population is rising high. this study aims to find out the effect of pku-type meals on appetite, appetite biomarkers, and post-meal energy expenditure. the investigators will recruit 26 healthy adults and ask them to participate in two experimental trials. on one occasion the participants will be asked to consume a pku-supplemented drink followed by a pku type-lunch and on another occasion the supplement and lunch will be based on normally consumed foods. series of blood samples will be taken and appetite will be assessed during both experiments. both experimental trials will finish with consuming an "all-you-can-eat" buffet.


Eligibility criteria:
inclusion criteria: 1. healthy adult 2. body weight stable for previous 4 months 3. regular menstrual cycle (females) exclusion criteria: 1. pregnancy or lactation (females) 2. history of eating disorder 3. history of gastrointestinal problems or surgery 4. history of allergy 5. history of chronic illness 6. on any medication 7. smoking 8. on nutritional supplements 9. following specific diet 10. currently taking part in other research

Keywords: low phenylalanine diet pku supplements diet induced thermogenesis appetite body weight
accelerated rehabilitation in hip arthroplasty

Conditions: Osteoarthritis

Summary: accelerated rehabilitation protocol in total hip arthroplasty (tha-ar).

the accelerated rehabilitation protocol in total hip arthroplasty (tha-ar) was designed to improve the functionality and optimize early discharge of patients undergoing tha surgery. this study compared physical therapy protocol in total hip arthroplasty (tha-pt) already deployed in porto alegre clinical hospital with tha-ar.

Eligibility criteria:
inclusion criteria: * patients of the public health system of our country that were admitted with hip osteoarthritis diagnose and submitted to a total hip arthroplasty surgery in the hospital de clínicas de porto alegre (hcpa). exclusion criteria: * patients who refused to participate in this study; * patients lived in another city; * patients undergoing surgery for total hip arthroplasty due to hip fracture; * patients with cognitive disorders or diseases that adversely affect its cognitive function (alzheimer's disease, senile dementia).

Keywords: osteoarthritis physiotherapy rehabilitation clinical trials accelerated rehabilitation hip replacement arthroplasty