Kornimate/medical-research-clean huggingface dataset:
early dha/ara supplementation in growth-restricted very preterm infants: a randomized clinical trial

Conditions: Infant Malnutrition; Light-For-Dates With Signs of Fetal Malnutrition; Premature; Nutrition Disorder, Infant

Summary: growth-restricted very preterm infants (vpt) are born without adequate fat mass (fm) deposits and low docosahexaenoic acid (dha) concentrations. they often experience further declines in dha concentrations during the initial three weeks post-birth while advancing enteral feeds and receiving lipid supplementation predominantly through parenteral nutrition. these suboptimal enteral and parenteral nutrition practices significantly heighten the risk of faltering postnatal growth. one promising approach to mitigate these issues is enteral dha supplementation. however, it remains unclear whether the early administration of dha through enteral supplementation could lead to a more substantial increase in head growth without affecting fm accretion in growth-restricted vpt infants. to address this question, we propose a masked randomized clinical trial involving 152 vpt infants.


Eligibility criteria:
inclusion criteria: * gestational ages between 22 0/7 - 32 6/7 weeks gestation * \< 25th centile birthweight exclusion criteria: * major congenital/chromosomal anomalies * terminal illness in which decisions to withhold or limit support have been made
the use of real time ultrasound feedback in teaching abdominal hollowing exercises

Conditions: Low Back Pain

Summary: recently, physical therapists have begun treating people who have mechanical low back pain, hypothesized to be caused by segmental instability in the lumbar spine, with a very specific exercise program consisting of trunk stabilization exercises. the theory behind the use of trunk stabilization exercises to treat lower back pain is that active contraction of the trunk local segmental muscles helps to control inter-segmental movement in the spine. the initial trunk stabilization exercise that physical therapists teach patients is an abdominal drawing in maneuver often called an abdominal hollowing exercise (ahe). a challenge for physical therapists is to establish the most effective means of teaching people to contract the relevant muscles needed to perform the ahe. the purpose of this study is to examine if supplementing the typical clinical instruction for teaching the ahe with visual ultrasound feedback to the patient is effective at reducing the length of time it takes an individual to learn to perform an ahe. three groups of research volunteers will be taught how to do the ahe while receiving different kinds of feedback about their performance in order to determine which type of feedback is most effective in assisting people to learn the ahe. group 1 will not receive any feedback about performance; group 2 will receive feedback from palpation and verbal descriptive alone; and group 3 will receive feedback from palpation, verbal descriptive feedback, and real time ultrasound. for the initial test when subjects are learning the ahe, the number of trials until the subject demonstrates his/her third correct ahe will be the outcome variable. for the retention test, the outcome variable will be the percentage of trials (out of ten) of correctly performed ahes in the absence of visual, verbal or palpation feedback.


Eligibility criteria:
inclusion criteria: * healthy volunteers

Keywords: abdominal hollowing exercises
bioinformation therapy for lung cancer

Conditions: Small-cell Lung Cancer

Summary: the aim of this study is the synergistic effect of cancer ablation and life information rehabilitation therapy on unresectable lung cancer.

by enrolling patients with unresectable lung cancer adapted to enrolled criteria, this study will document for the first time the synergistic effect of cancer ablation and life information rehabilitation therapy. the efficacy will be evaluated according to local relief degree, progress free survival (pfs) and overall survival (os).

Eligibility criteria:
inclusion criteria: * all standard therapies have failed according to nccn guidelines or the patient refuses standard therapies * body tumor 1-6, with at least one tumor length \> 2 cm * kps ≥ 70, lifespan \> 6 months * platelet count ≥ 80×109/l，white blood cell count ≥ 3×109/l, neutrophil count ≥ 2×109/l, hemoglobin ≥ 80 g/l exclusion criteria: * patients with cardiac pacemaker * patients with brain metastasis * patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Keywords: cancer ablation life information rehabilitation therapy
reveal linq registry

Conditions: Arrhythmias, Cardiac

Summary: the reveal linq registry will generate reliable long-term "real world" data of product performance, economic valuation, site-of-service procedural information.

the study is a prospective, non-randomized, observational, multi-center, global study. the study will characterize clinical actions initiated by reveal linq arrhythmia detection and estimate procedure-related acute infection rate. approximately 1,500 subjects will be implanted with a reveal linq icm and undergo continuous remote monitoring and be followed prospectively from insertion through 36 months.

Eligibility criteria:
inclusion criteria: * subject or legally authorized representative provides written authorization and/or consent per institution and geographical requirements. * subject is intended to receive or be treated with the have a reveal linq icm inserted in the next 30 days. * patient enrolled before or on the same date of insertion of the reveal linq icm * subject consent prior to icm insertion exclusion criteria: * subject who is, or is expected to be inaccessible for follow-up * subject with exclusion criteria required by local law * subject is currently enrolled in or plans to enroll a concurrent study that may confound the results of this study. co-enrollment in any concurrent drug and/or device clinical study (including registries) requires approval of the study manager or designee.
relationship between the arthroscopic anatomy of the middle glenohumeral ligament and the rotator cuff tear position

Conditions: Rotator Cuff Tears

Summary: the main aim and scope of this study is making observation and comparing the difference in the tear position in the patients suffered form rotator cuff tear with different arthroscopic anatomy of the middle glenohumeral ligament. the results may identify the influence of the middle glenohumeral ligament anatomy type on the rotator cuff tear.


Eligibility criteria:
inclusion criteria: * partial or full-thickness but reparable rotator cuff tear; * small- to large-sized rotator cuff tears being defined by deorio and cofied4; * no improvements after at least 1 month of conservative treatment such as nsaids or corticosteroid injection. exclusion criteria: * massive rotator cuff tears being defined by deorio and cofied; * patients with osteoarthritis of the glenohumeral joint; * trauma or a history of surgery at the shoulder.

Keywords: rotator cuff tears middle glenohumeral ligament arthroscopic anatomy
hfn versus niv in cystic fibrosis. the hifen study

Conditions: Cystic Fibrosis

Summary: many patients with cystic fibrosis (cf) require hospitalization and/or intensive care unit (icu) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status. non-invasive ventilation (niv) is the first option for the clinical management of cf patients with moderate-to-severe respiratory distress and niv has been shown to improve gas exchange, reduce respiratory muscle work and improve pulmonary function in patients with obstructive lung disease in general and those with acute cf exacerbation. high-flow nasal oxygen cannula (hfn) is a relatively new system providing heated and humidified, high-flow (50l/min) oxygen through the nostrils. this device provides a small positive pressure, probably washes-out the pharyngeal dead space, reduces inspiratory resistance, and possibly facilitates secretion clearance. the technique is very well tolerated. from a physiologic standpoint, this device could help cf patients by improving gas exchange, reducing respiratory workload, and facilitating mucus clearance. non-interrupted delivery may be possible given better clinical tolerance in contrast with bi-level positive pressure niv. whether the short-term physiological efficacy of hfn is comparable to niv is unknown and there is no study on the benefit of hfn in cf patients. the aim of this study is to compare the physiological effects of hfn and niv in cf patients requiring ventilatory support. our hypothesis is that hfn will not be inferior to niv, as evaluated by breathing pattern, gas exchange, and respiratory workload and will decrease dead space. in addition, comfort and preference between the two techniques will be evaluated.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * cystic fibrosis as defined by clinical features in conjunction with 2 cf causing mutations and/or 2 sweat tests with sweat chloride \> 60 mmol/l * clinical indication for niv based on at least one of the following criteria: * signs of clinical respiratory distress - rr \> 24/min, accessory muscle use, or increased dyspnea * progressive increase in arterial pco2 * nocturnal hypoventilation treated by niv but requiring daytime niv because of clinical worsening exclusion criteria: * active massive hemoptysis * pneumothorax with pleural drainage and persistent air leak * hemodynamic instability requiring vasopressors * uncooperative * recent upper airway or esophageal surgery * patients with skin or chest wall or abdominal trauma

Keywords: cystic fibrosis high-flow nasal oxygen cannula non-invasive ventilation respiratory distress oxygen therapy
culturally modified family based therapy for haitian youth in south florida

Conditions: Problem Behavior

Summary: the ciffta study is a unique intervention that will develop and implement a culturally-specific, family-based individual, drug use, sexual risk and delinquency risk reduction program for haitian youth ages 13-17 in miami-dade county, florida.

haitian youth in miami-dade county who become part of the juvenile justice system have not received culturally appropriate remediating or rehabilitative attention by that system. this study will modify a specific variety of intervention, the culturally informed and flexible family-based treatment for adolescents (ciffta) for appropriateness in miami's haitian cultural contexts. this study will develop and implement a culturally specific, family-based adolescent therapy, drug use, sexual risk and delinquency risk reduction program for haitian adolescents aged 13-17 in miami-dade county, florida.

Eligibility criteria:
inclusion criteria : * adolescents aged 13 to 17 * place of residence is miami-dade * has haitian ancestry * adolescents not incarcerated * no prior mental health care or history of psychoactive medication * adolescents who have lived in the us for 3 years exclusion criteria: - youths with a documented history of mental retardation and/or organic dysfunction.
paclitaxel-bevacizumab in advanced lung cancer

Conditions: Non-squamous Non-small Cell Lung Cancer

Summary: the study objective is to evaluate the efficacy of paclitaxel-bevacizumab comparing to docetaxel. docetaxel is a standard treatment of 2nd or 3rd line in lung cancer. it was validated by numerous clinical trials but sometimes toxicities are difficult to manage. bevacizumab is an antiangiogenic treatment which was validated by numerous clinical trials in association with platinum in first ligne. different clinical and preclinical data suggest that there could exist a synergy between paclitaxel and bevacizumab. this association is already used in metastatic breast cancer, it permits almost to double the response rate and progression free survival. in lung cancer, the association was evaluated by two retrospective studies which demonstrated a benefit with a favourable safety profile.


Eligibility criteria:
inclusion criteria: * 2nd or 3rd line of non squamous non small cell lung cancer of stage iii or iv * document progression at the time of the inclusion. at least, one previous chemotherapy line with platinum. patient who had previous treatment with bevacizumab can be included. * patient with active mutation of egfr must have had on line of chemotherapy with platinum and one with tyrosine kinase inhibitor of egfr. * patient with alk rearrangement must have had at least one line of chemotherapy with platinum and one with crizotinib. exclusion criteria: * mixed cancer small cells and non small cells or squamous lung cancer. * central nervous system symptomatic metastasis or requiring immediate cerebral radiotherapy * patient who have had previous treatment with taxane (docetaxel, paclitaxel). peri-operatory chemotherapy or chemoradiotherapy with taxane allowed if stopped more than 6 months before.

Keywords: lung cancer paclitaxel bevacizumab ifct
effect of instrument-assisted soft tissue mobilization versus myofascial release in treatment of mechanical neck pain

Conditions: Neck Pain; Soft Tissue Injuries

Summary: mechanical neck pain has become a major health problem recently, affecting around one-year prevalence ranging from 42 to 67% in young adults aged 20-24 years causing pain and functional deficits. no study has been conducted before to investigate the effect of instrument assisted soft tissue mobilization (iastm) with mechanical neck pain on university students involved in distance learning.

mechanical neck pain is a major social and economic burden. it showed a one-year prevalence ranging from 42 to 67% in young adults aged 20-24 years. treatment of neck pain is costly in terms of utilization of health care services, disability, compensation payments and lost work productivity. with the increasing prevalence of pain and disability associated with musculoskeletal impairments, it is essential to identify the most efficacious interventions to maximize patient outcomes and decrease the societal burden.

Eligibility criteria:
inclusion criteria: 1. patient's age will be between 18-25 years old. 2. subjects with mechanical neck pain localized to cervical and periscapular region. 3. subjects with at least one trigger point in the upper trapezius and/or levator scapulae muscles 4. subjects should report mechanical neck pain of at least 30 mm on a visual analogue scale (vas). the scale is ranged from 0 mm (no pain) to 100 mm (worst imaginable pain). 5. subjects who use computers daily for at least two hours and are involved in distance learning for at least three months. exclusion criteria: 1. any specific neck pathology as radiculopathy, rheumatoid arthritis, and systemic diseases. 2. sensory problems at mid or upper back 3. a tendency to hemorrhage or anticoagulation treatment. and nonsteroidal pain medication 4. history of head and upper trunk trauma or surgery. 5. signs of severe pathology such as malignancy, fractures of the cervical spine, cervical radiculopathy or myelopathy, or vascular syndromes such as vertebrobasilar insufficiency.
social and emotional brain function in cannabis users

Conditions: Cannabis Dependence

Summary: the aim of this functional magnetic resonance imaging (fmri) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. previous research in cannabis users has predominantly focused on cognitive functions. moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. findings might provide important information with respect to relapse vulnerability.


Eligibility criteria:
inclusion criteria: * cannabis dependence according to dsm 4 criteria * 28 days of supervised abstinence exclusion criteria: * other dsm 4 diagnosis * neurological disorders

Keywords: addiction cannabis fmri
multiple ascending doses (mad) of azd3199 given once daily as inhaled formulation via turbuhaler to healthy men

Conditions: Healthy Volunteers

Summary: the purpose of this study is to investigate the safety and tolerability of multiple once daily ascending doses of azd3199 in healthy men


Eligibility criteria:
inclusion criteria: * bmi 19-30, weight 60-100 kg * non/ex-smokers, non/ex-nicotine users exclusion criteria: * any clinically significant disease or disorder * any clinically relevant abnormal findings at screening examinations * use of any prescribed or non-prescribed medication

Keywords: healthy male tolerability safety inhalation
comparison of multiradius and singleradius total knee arthroplasty

Conditions: Gonarthrosis; Primary; Gonarthrosis; Gonarthrosis; Primary, Bilateral; Knee Osteoarthritis; Knee Arthritis

Summary: the investigators would like to compare multiradius and single-radius total knee arthroplasty using with association between sagittal patellar offset and anterior knee pain in subjects having undergone bilateral total knee replacement.

a prospective, interventional study. a total of to 494 subjects requiring bilateral multiradius( n=247) and singlerasius(n=247) knee arthroplasty will be enrolled. anterior femoral offset, femoral diameter and patellar offset will be measured by orthopaedic surgeons. in addition, visual analogue scale score, oxford knee score, womac, sf12 and sf36 will be evaluated postoperative in patients long-term follow up to see if there is a relationship between anterior femoral offset and anterior knee pain. in the direct lateral knee joint radiograph, the distance between the two parallel axis extending from both cortices of the femur is measured as "femoral diameter".the remaining length between the anterior axis and the maximum peak at the anterior of the prosthesis is considered as an "anterior femoral offset". sagittal patellar offset is accepted by us as the ratio of the anterior femoral offset to the remaining distance between the maximum anterior point of the patella and the posterior vertex in the direct lateral knee joint radiography.

Eligibility criteria:
inclusion criteria: * clinical and radiological diagnosis of end-stage primary gonarthrosis exclusion criteria: * history of malignancy, * severe extraarticular deformity, * posttraumatic and septic arthritis sequel

Keywords: multiradius singleradius total knee arthroplasty sagittal patellar offset anterior knee pain
effect of post-operative anesthetics on post-operative pain in patients receiving endodontic treatment

Conditions: Endodontic Disease; Post Operative Pain; Symptomatic Irreversible Pulpitis

Summary: this study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.

the goal of this study is to assess the efficacy of 2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine in reducing post-operative pain in patients with symptomatic irreversible pulpitis on a mandibular tooth that receive endodontic treatment. participants of this study will include patients that present to the university of washington endodontic clinic and fit the inclusion criteria of being \>18 years old, healthy (asa i or ii) and having a diagnosis of symptomatic irreversible pulpitis on a mandibular tooth, that is willing to undergo endodontic treatment in two visits. upon diagnosis, and informed consent, patients will be asked to participate in this study. if enrolled in the study, participants will receive standard endodontic treatment with temporary placement of calcium hydroxide medicament within the canals of the tooth and placement of a temporary filling. they will then be randomized to receive an inferior alveolar nerve block with 1 cartridge (1.8ml) of either 2% lidocaine 1:100,000 epinephrine or 0.5% bupivicaine 1:200,000 epinephrine. patients will be given a form to track their pain levels for the next 72 hours, that they will return at a follow up visit. this form will use the heft-parker visual analog pain scale to track pain levels as well as ask participants to track their use of over the counter analgesics, in particular, advil/ibuprofen. the pain tracking form will be returned to the clinic and root canal will be completed also at this follow up visit.

Eligibility criteria:
inclusion criteria: * diagnosis of symptomatic irreversible pulpitis on mandibular, posterior tooth * asa i or ii * \>18 years old exclusion criteria: * maxillary or mandibular anterior tooth * diagnosis of pulp necrosis or reversible pulpitis * tooth deemed non-restorable * \<18 years old * asa iii, iv, or v * patients who are contraindicated to take ibuprofen * patients with allergies to any medications being assessed in this study

Keywords: endodontics root canal lidocaine bupivicaine ibuprofen symptomatic irreversible pulpitis post operative pain heft parker visual analog scale
aspirin and enalapril in microalbuminuric type 2 diabetes mellitus patients

Conditions: Diabetes Mellitus; Microalbuminuria

Summary: research design: randomized, double-blind, placebo-controlled crossover study to evaluate the putative interference of low-dose aspirin (for 8 weeks) on enalapril antiproteinuric properties in microalbuminuric type 2 diabetes mellitus patients

research design: randomized, double-blind, placebo-controlled crossover study patients: microalbuminuric (urinary albumin excretion \[uae\]30-300 mg/d)type 2 diabetes mellitus patients without ischemic heart disease or peptic ulcer aim:to evaluate the putative interference of low-dose aspirin (300 mg/d)for 8 weeks)on enalapril antiproteinuric properties in microalbuminuric type 2 diabetes mellitus patients study protocol:crossover randomization to 8 weeks of enalapril 10 mg/d plus aspirin (300 mg/d) or plus placebo, and a 6-week washout period. measurement of uae (immunoturbidimetry) and glomerular filtration rate (51cr-edta), blood pressure and metabolic control at baseline and at the end of each period. statistical analyses: bland\&altman analyses for crossover trials.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus microalbuminuria exclusion criteria: * ischemic heart disease peptic disease

Keywords: aspirin enalapril microalbuminuria glomerular filtration rate
a retrospective analysis of pancreatic injuries and treatment outcomes

Conditions: Pancreatic Trauma; Pancreatic Duct Injury; Pancreas Necrosis; Pancreas Cyst; Pancreas; Fistula; Pancreas Abscess; Intra-Abdominal Abscess; Anastomotic Leak; Pancreas Injury

Summary: the goal of this observational study is to compare the presentation, treatment, and outcomes in patients suffering traumatic pancreatic injuries from blunt or penetrating trauma. the questions this study aims to answer are: 1. does a statistically significant association exist between pancreatic injury grade and the following individual factors: * mortality * morbidity * injury severity score 2. is there an association between post-operative pancreatic complications and operation-specific intervention? 3. does pancreatic injury score correlate with certain intra-abdominal organ injuries? participants meeting criteria are greater than 18 years old, with no history of pancreatic surgery who were hospitalized at kern medical center after presenting to the institution's emergency department as tier 1 or 2 trauma activations following blunt or penetrating abdominal injury and were diagnosed with pancreatic injury during the same hospitalization.


Eligibility criteria:
inclusion criteria: * hospitalized at kern medical center after presenting to the institution's emergency department as a tier 1 and 2 trauma activation * hospitalized following blunt or penetrating abdominal injury * diagnosed with traumatic pancreatic injury during same admission exclusion criteria: * history of pancreatic surgery * iatrogenic pancreatic injuries

Keywords: pancreatic trauma penetrating abdominal injury abdominal trauma