Kornimate/medical-research-clean huggingface dataset:
impact of community-based biofeedback program on drug use and mental health among people experiencing homelessness

Conditions: Heart Rate Variability

Summary: the purpose of this randomized controlled trial was to compare the effectiveness of an hrv-bf intervention versus a health promotion active control intervention focused on improving mental health symptoms among people experiencing homelessness (peh), who were residing in skid row, los angeles. in total, 40 peh were randomized to either the hrv-bf or an active health promotion control group, and received 8 weekly, 30-minute sessions over a two month period, delivered by a nurse-led community health worker team. dependent variables of hrv, mental health, anxiety, depression and ptsd were measured at baseline, the 8-week session, and/or 2-month follow up.

in this pilot randomized controlled trial, conducted over one year, beginning in april 2021, 40 peh were recruited from a larger sample of 100 peh that were participating in a survey on covid-19. our outcomes were hrv and symptoms of anxiety, depression and ptsd. prior to the intervention, a community advisory board (cab) met to assess feasibility and acceptability of the hrv-bf program, which was presented in a theater-style approach. the cab, composed of 6 peh, and 3 healthcare providers, spoke quite favorably about the program, and provided exceptional feedback in terms of acceptability and feasibility in delivery logistics and cultural sensitivity. peh shared the high levels of stress and anxiety they were experiencing; how helpful they perceived the program to be, the best timing for delivery, length of time for the intervention (under 60 minutes), and how to minimize attrition. our study was approved by the human subjects protection committee at the university of california, irvine and the university of california, los angeles.

Eligibility criteria:
inclusion criteria: * age 18 and older * self-reported as residing in a homeless living condition during the previous night * self-reported having used illicit substances or alcohol during the past year exclusion criteria: persons who: * exclusively spoke languages other than english or spanish * were unable to understand informed consent * had cardiac deficiency, arrhythmias or pacemakers or who took medications affecting autonomic function.

Keywords: heart rate variability mental health anxiety depression ptsd
descriptive study of strength training exercises to activate the muscles of the operated leg after total knee replacement

Conditions: Osteoarthritis, Knee

Summary: background: in the early phase after a total knee replacement (tka), patients experience multi-level weakness in the operated leg, which is caused primarily by reduced central (cns) activation failure of the muscles - especially the knee extensors. this considerable loss of muscle strength relates to reduced functional performance. the investigators recently reported that early-commenced physiotherapy, including progressive strength training performed in machines, seems feasible after tka. the question is, if neuromuscular activity of the muscles in the operated leg, elicited during strength training in machines, can be reached during strength training in more simple forms? many clinicians are faced with the problem of not having strength training equipment at their institution, or having to prescribe simple strength training exercises for home-based training. purpose and hypothesis: the purpose of this study is to determine which strength training exercises that activate the muscles in the operated leg the most after tka. the hypothesis is that strength training exercises performed in machines is more effective compared to strength training performed in more simple forms (using elastic bands or own body weight, etc.). participants and methods: twenty participants with a unilateral tka, operated between 4 to 8 weeks prior to the first investigation, will be included. the participants are investigated twice. during the first investigation, the absolute load (kilograms) corresponding to 10 repetition maximum (rm) (a load that can be lifted exactly 10 times) will be determined for all the exercises. at least 72 hours later, the participants will undergo an electromyographic analysis, which determines the neuromuscular activity of the thigh muscles in the operated leg. ethical issues: from a pilot study, the investigators found that strength training exercises commenced early after tka seems feasible as the exercises did not increase knee joint swelling or knee pain. none of the financial supporters, or any of the authors, have any potential conflicts of interest with regard to the study.


Eligibility criteria:
inclusion criteria: * unilateral primary tka * between the age of 18 to 80 years * understand and speak danish * informed consent * 4 to 8 weeks after tka exclusion criteria: * disease/musculoskeletal disorder, which requires a special rehabilitation modality * alcohol and drug abuse * lack of wish to participate or unwillingness to sign an informed consent

Keywords: arthroplasty, replacement, knee electromyography resistance training physical therapy modalities
traditional thai massage and scapulocostal syndrome

Conditions: Scapulocostal Syndrome

Summary: the purpose of this study is to evaluate the efficacy of traditional thai massage on pain intensity, pressure pain threshold, muscle tension, anxiety, cervical range of motion, patient satisfaction and side effects in the treatment of scapulocostal syndrome.


Eligibility criteria:
inclusion criteria: 1. male or female 2. age between 18 - 50 years old 3. the participants have experienced spontaneous scapular pain (vas ≥ 3) for longer than 12 weeks (chronic) and that at least one trigger point will be present in the scapular region (serratus posterior superior, rhomboid groups, levator scapulae and trapezius muscles). trigger points will be diagnosed as the presence of focal tenderness in a taut band and with pain recognition. 4. the participants will be able to follow instructions. 5. good communication and cooperation. exclusion criteria: 1. a history of the following diseases or disorders: * rotator cuff disease * cervical radiculopathy * degenerative shoulder joint disease * shoulder stiffness 2. contraindications of traditional thai massage * contagious skin disease * injury or inflammation of muscle * bone fracture and/or joint dislocation * open wound * uncontrolled hypertension * drug and/or alcohol intoxication

Keywords: traditional thai massage scapulocostal syndrome
controlled study of ono-1101 in patients with postoperative tachyarrhythmias in japan

Conditions: Postoperative Supraventricular Tachyarrythmia

Summary: the purpose of this study was to evaluate the dose-dependent effects of ono-1101 on efficacy and safety in patients with postoperative supraventricular tachyarrhythmias.


Eligibility criteria:
inclusion criteria: 1. 20-80 years old 2. postoperative supraventricular tachyarrhythmias (sinus tachycardia, those with a heart rate of 120 beats/min or higher, and supraventricular arrhythmia, those with a heart rate of 100 beats/min or higher) 3. within 7 days postoperatively 4. other inclusion criteria as specified in the protocol exclusion criteria: 1. acute myocardial infarction (within 1 month after onset) 2. severe heart failure (new york heart association functional class iii or higher) 3. atrioventricular block (grade ii or higher),or sick sinus syndrome 4. other exclusion criteria as specified in the protocol

Keywords: ono-1101,landiolol hydrochloride, postoperative, supraventricular tachyarrhythmia
efficacy and safety of mucoadhesive sustained release, mucodentol, in comparison with hydroxychloroquine to prevent covid-19

Conditions: COVID-19

Summary: 180 people from the medical staff and high-risk people in baqiyatallah hospital, who are in close contact with patients, will enter the study. participants will be divided into two intervention groups and one control group. the control group will use the full protective equipment assigned to the treatment staff. in addition to protective equipment, the first intervention team will receive a daily diet of 200 mg hydroxychloroquine tablets. the second intervention team, while observing and using the complete protective equipment, will place a thin layer of mucodentol gel in the vestibular area of the mouth daily, every 6 to 8 hours. at the beginning of the treatment, qualified people will participate in the study while recording demographic and clinical information, pcr test will be performed, and if they have negative pcr, they will be in one of the 3 study groups. during the study, if the symptoms of the disease occur in each of the participants, the test will be taken again. if the test is positive, the person will withdraw from the study, and the patient's information will be recorded. finally, the people present in the study will be tested for pcr, and the results of the disease and the side effects of the drugs will be compared.


Eligibility criteria:
inclusion criteria: * negative pcr testing through throat swabs * signing conscious consent exclusion criteria: * history of ocular complications and visual disturbances * sensitivity to plant compounds in the product
combined biofeedback with virtual reality in the treatment of pediatric headache

Conditions: Chronic Headache

Summary: the objective of the study is to examine the effect of combined treatments (biofeedback with virtual reality) for pediatric chronic headache.

chronic headache is a common symptom in children. pharmacologic treatment has only a limited productivity and several known adverse reactions. despite the frequency and chronicity of pediatric headache, validated treatment paradigms are currently inadequate. biofeedback is a medical treatment in which physiologic markers like heart rate, breathing rate, emg, eeg, or electrodermal activity are measured and displayed back to the patient. the patient can then attempt to modulate physiology to achieve a certain feedback goal,such as slowing heart or breath rate, or relaxing certain muscles. numerous psychophysiologic studies have been conducted that examine the effect of biofeedback alone on physiology as well as various clinical conditions. clinical trials for chronic headaches have found that biofeedback was more effective in the treatment of headache when compared to pure drug therapy. a number of recent distraction interventions for acute pain in children and adolescents have employed virtual reality technology in conjunction with either a passive distraction stimulus, such as a movie, or an interactive distraction activity, such as a computer game. however, the actual benefit of vr technology over and above the benefits of the distracting stimulus that is experienced through the vr equipment has not been adequately tested in children. the objective of this study is to combine virtual reality with biofeedback in order to increase the effectivity of both techniques in decreasing chronic headache frequency and pain degree in the pediatric population.

Eligibility criteria:
inclusion criteria: * 9-18 years old children suffering from chronic headache diagnosed by pediatric neurologist * exclusion of other disorders causing chronic headache exclusion criteria: * children younger than 9 years or olde than 18. * children who do not fulfill headache criteria as described in the international headache society * children who were not examined by a certified pediatric neurologist

Keywords: headache pediatric virtual reality biofeedback
instrumental versus standard rehabilitation for knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: a randomized clinical trial to evaluate the effectiveness of an instrumental rehabilitation protocol compared with standard protocol in patients with knee osteoarthritis.

this is a randomized clinical trial designed to compare two intervention aimed at reducing and improving knee function in patients with knee osteoarthritis - sixty subjects suffering from knee osteoarthritis will be recruited; 30 per group. a: instrumental rehabilitation b:standard rehabilitation all patients who meet the clinical inclusion and exclusion criteria will have a standard radiography * selected patients will be invited to participate and will be informed of the purpose and conduct of the study * patients will be randomized to either the instrumental rehabilitation programme groupe or the standard rehabilitation group * patients in both groups will have a protocol that will be extended over 6 weeks * participants will be assessed primarily for function and pain, as well as other secondary endpoints , at baseline at 3 weeks and at 12 weeks.

Eligibility criteria:
inclusion criteria: * patients with radiologically confirmed uni/ bilateral gonarthrosis exclusion criteria: * will be excluded from our study: * subjects with congestive gonarthrosis (joint effusion at clinical examination). * patients followed for chronic inflammatory rheumatism. * patients who are candidates for surgery for knee osteoarthritis * patients with a pathology causing a limitation in walking distance apart from gonarthrosis. * amputees of one or both lower limbs.

Keywords: rehabilitation knee osteoarthritis
neoadjuvant chemo (gemcitabine and cisplatin) with radical cystectomy or radiotherapy in patients with bladder cancer

Conditions: Bladder Cancer

Summary: the purpose of this study is to evaluate efficacy of gemcitabine and cisplatin combined with either radical cystectomy or radiotherapy in the treatment of bladder cancer.


Eligibility criteria:
inclusion criteria: * histologically or cytologically proven urothelial carcinoma of the urinary bladder in stage t2b-t3, n0/nx, m0. * patients must have measurable disease. response assessment will be evaluated according to recist criteria. measurable lesions with clearly defined margins will be evaluated by x-ray, transvesical ultrasound, ct-scan or mri, cystoscopy. * lesions serving as measurable disease must have the longest diameter of greater than or equal to 20 mm as measured with conventional techniques or greater than or equal 10 mm with spiral ct scan. lesions measured by physical examination must have a longest diameter of greater than or equal 20 mm. exclusion criteria: * patients with prior or concomitant malignant diseases (other than appropriately treated basal cell carcinoma of the skin or carcinoma of the cervix) * psa greater than 5.0 ng/ml * concurrent administration of any other tumor therapy, including radiotherapy, cytotoxic chemotherapy, immunotherapy, molecular target therapy.
evaluating the effects of cimetidine on the elimination of pd 0332334 from the body

Conditions: Generalized Anxiety Disorder

Summary: the purpose of this study is to estimate the effects of multiple doses of cimetidine on the pharmacokinetics of a single dose of pd 0332334 and to evaluate the safety and tolerability of pd 0332334 when co-administered with cimetidine.

detailed description: additional study purpose details: evaluate the effects of multiple doses of cimetidine on the pharmacokinetics (e.g., elimination from the body) of a single dose of pd 0332334. on february 18th 2009, a decision to terminate further development for pd 0332334 was communicated to investigators in this study. the decision to terminate this study was not based on any safety concerns.

Eligibility criteria:
inclusion criteria: * healthy * male or female adults exclusion criteria: * current or history of clinically significant medical illness * smokers * illicit drug use

Keywords: cimetidine, pd 0332334, organic cation transporter, oct2, pharmacokinetics
the effects of thoracic spine mobilizations in individuals with neck pain.

Conditions: Neck Pain

Summary: to determine the affects of physical therapists clinical reasoning using thoracic spine mobilization for neck pain compared to a standard protocol.

the purpose of this research is to compare the effects of two commonly used, safe, thoracic spine treatments: grade 1-4 as performed by cleland et. al. and grade 1-4 mobilization to the thoracic spine as selected by the physical therapist for cervical spine pain. the immediate effects of thoracic spine mobilization have been shown to facilitate greater range of motion increases in the cervical spine and greater pain decreases within a treatment session and on follow-up visits. there is no research utilizing pain threshold perception as an objective outcome of these treatments. only one study compared the two treatment techniques and concluded that future research should be completed which includes manual therapy for the thoracic spine. (cleland 2007) if the pt identifies an appropriate patient they will ask if they are interested in being a research subject. the physical theapist recruiting subjects all have completed their doctor of physical therapy degree and have advanced training in manual physical therapy. the techniques employed are considered standard practice and are defined as entry level skills by the comission of accredicdation of physical therapy programs. these techniques are typically taught in dpt degree programs.

Eligibility criteria:
inclusion criteria: * patients with neck pain * ages 18 - 60 exclusion criteria: * red flags: leg weakness, night pain, history of cancer, upper motor neuron signs, infection, tumors, osteoporosis, fracture (boissonnault, 2011) (cleland, 2004), cervical stenosis, cns involvement, signs consistent with nerve root compression, previous surgery, pending legal action the inclusion and exclusion above represent a conservative approach based on combining criteria of recent studies in published review articles. (cross, 2011; walser, 2009
a study to evaluate the effect of tacrolimus and corticosteroid combination therapy in patients with minimal change nephrotic syndrome

Conditions: MCNS; Minimal Change Nephrotic Syndrome (MCNS)

Summary: to compare the therapeutic effect of tacrolimus in combination with low-dose corticosteroid with high-dose corticosteroid alone in patients with minimal-change nephrotic syndrome.


Eligibility criteria:
inclusion criteria: * patients who have been diagnosed with initial or relapsed primary minimal-change nephrotic syndrome * patients whose urine protein-creatinine ratio (upcr) is more than 3.0 exclusion criteria: * patients whose egfr is less than 30 ml/min/1.73 m2 * patients who were treated with immunosuppressants, such as tacrolimus, cyclosporine, cyclophosphamide (cytoxan), mizoribine (bredinin), levamisole, azathioprine, mycophenolate mofetil, or rituximab, within two weeks before the study * patients to whom more than 10 mg prednisolone or an equivalent dose of steroid was administered daily within two weeks before the study * patients who are pregnant, breastfeeding, or planning to be pregnant or to breastfeed within six months after the study completion, or who cannot or do not want to use any contraceptive method * patients who are hypersensitive to the investigational drug or to macrolide, such as azithromycin, clarithromycin, or roxithromycin * patients who were treated with a live vaccine within four weeks before the study * patients whose liver panel laboratory test result is three times the normal range, or acute hepatitis patients whose serum bilirubin has been clinically significantly higher than 3.6 mg/dl for more than 1 month * patients who have a significant general disease that makes it inappropriate for them to participate in this study as adjudged by the investigator (e.g., cardiovascular-acute myocardial infarction, heart failure \[classified as more than new york heart association {nyha} class iii\], hepatic/gastrointestinal/neurologic disease, blood disorder, cancer, infection, renal disorder other than minimal-change nephrotic syndrome, rheumatic arthritis with pneumonia interstitials) * patients who have genetic problems such as galactose intolerance, lapp lactose deficiency, or glucose-galactose malabsorption * patients to whom another investigational drug was administered within 30 days from the enrollment in the study * patients who participated in the past phases of this study

Keywords: glomerulonephritis tacrolimus nephrotic syndrome
clinical trial to evaluate the safety and efficacy of "theobromine capsule" as an antitussive in acute cougher

Conditions: Acute Bronchitis

Summary: the aim of this clinical trial is to evaluate the antitussive effect of "theobromine capsule 300mg" in patients with acute bronchitis.

this study is double blinded, randomized, parallel designed, phase iii clinical trial to evaluate the efficacy and safety of "theobromine capsule 300mg" versus "levodropropizine syrup" in patients with acute bronchitis.

Eligibility criteria:
inclusion criteria: 1. patient who decided to participate in this clinical trial at his(her) own will and agreed in written letter of consent. 2. adult aged over 18 3. patient who has cough symptom caused by acute bronchitis 4. patient who go to see the doctor for severe cough at his(her) own will 5. dcs score at screening vist sould be over 3. 6. for fertile woman, hcg test at screening visit shloud be negative. patient who will continue to cough more than 1 week.(by physician's judgment) exclusion criteria: 1. patient who is accompanied by the seriously abnormal symptom in respiratory system, such as acute infectious pulmonary disease, tuberculosis, asthma. 2. chronic bronchitis including bronchial obstruction 3. patient who has clinical history of sensitivity to xanthine drug. 4. patient who has peptic ulcer 5. patient whose liver or kidney function is seriously abnormal: including the cases of sgot, sgpt, bilirubin and blood creatinine value exceeding twice of their upper normal limit. 6. patient whose heart function is abnormal: including the case of showing abnormal ekg test value that is clinically significant. 7. patient who has convulsion or alcoholism. 8. patient who has experience to have participated in other clinical trial within two months before starting the trial. 9. pregnant woman, lactating woman. 10. patient who thought to be cured within 3 days without any medicine.

Keywords: theobromine cough acute bronchitis
re-irradiation for pelvic recurrences in rectal cancer patients

Conditions: Rectal Cancer; Recurrence; Radiation Toxicity

Summary: this study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase ii clinical, imaging and translational research study.

the overall purpose of this trial is to evaluate the efficacy of re-irradiation of patients with locally advanced rectal cancer (lrrc) recurrences who previously received pelvic irradiation. patients with potentially resectable lrrc will be treated with hyperfractionated intensity-modulated radiotherapy consisting of 40.8 gy in 1.2 fractions twice daily with concomitant oral capecitabine followed by surgery, when feasible.

Eligibility criteria:
inclusion criteria: * locally recurrent rectal cancer * previous pelvic rt for rectal cancer and surgery * potentially resectable by mri and palpation by mdt evaluation * absence of non-resectable distant metastases by pet-ct * age ≥ 18 * adequate organ function * acceptable bowel and bladder function * acceptance for tr sampling exclusion criteria: * central small recurrences deemed immediate resectable * previous radiotherapy \<12 month prior to recurrence * non-resectable systemic or regional disease * unable to undergo mri or pet-ct * medical comorbidities precluding radical surgery