Kornimate/medical-research-clean huggingface dataset:
baduanjin training for depression and anxiety patients

Conditions: Depression Symptoms; Anxiety Symptoms

Summary: in recent years, the number of people with symptoms of depression or anxiety are on the rise. the aims of the prospective randomized study are: (1) to examine the effects of baduanjin breathing training on reducing symptoms of depression or anxiety, and (2) to explore the correlates between improvements of depression or anxiety symptom and changes of lung functions.

depression and anxiety, the two common mental health problems, are prevalent in the world. but there is a lack of sufficient no-drug intervention for relieving these two symptoms. the study focuses on mixed depressive and anxiety disorder, which symptoms are not sufficiently severe, numerous, or persistent to justify a diagnosis of depressive disorder or an anxiety disorder. baduanjin is a form of mind-body exercise with a profound philosophical foundation rooted in oriental culture. previous studies have provided some evidences of beneficial effects on baduanjin for depression and anxiety. moreover, the effects and mechanisms of baduanjin on patients with symptoms of depression and anxiety are yet to be further investigated. this is a two-group prospective, randomized, assessor-blinded trial, planning to enroll 120 participants (60 for baduanjin intervention group receiving health education plus a baduanjin breathing training program, and 60 for health education control group only receiving health education). the aims of the prospective randomized study are: (1) to examine the effects of baduanjin breathing training on reducing symptoms of depression or anxiety, and (2) to explore the correlates between improvements of depression or anxiety symptom and changes of lung function.

Eligibility criteria:
inclusion criteria: * subject with depression or anxiety symptom diagnosed by icd-10. * depression 7≤hamd-17≤29，anxiety 7≤hama-14≤29. * subject has a clear mind and the ability to read, to talk and to communicate. * subject agrees to participate in this study and sign to the informed consent. exclusion criteria: * subject with bipolar disorder, psychotic disorder, organic mental disorder and cognitive disorder. * subject with alcohol abuse, substance dependence and suicidal behavior in past-year. * subject has severe somatic disease. * subject is pregnant or lactating women.

Keywords: baduanjin depression anxiety randomized controlled trial
new castle disease virus (ndv) in glioblastoma multiforme (gbm), sarcoma and neuroblastoma

Conditions: Glioblastoma; Sarcoma; Neuroblastoma

Summary: patients with specific metastatic cancers who failed prior therapeutic regimes will be treated with ndv for at least a year or until disease progression. the study will measure progression-free disease and posits that it will be extended.

present therapeutic regimes have not much improved the survival of patients with metastatic cancer. therapeutic cancer vaccines are a form of immunotherapy designed to educate the immune system to recognise tumor cells as foreign rather than self. new castle virus (ndv) has a long history as a broad system oncolytic that can destroy tumor cells and stimulate the immune system. up to 30 patients suffering from recurrent, refractory glioblastoma multiforme, soft an bone sarcomas and disseminated neuroblastoma will be enrolled in this trial and receive daily doses of ndv at least 5 days a week for a minimum of a year or until disease progression.

Eligibility criteria:
inclusion criteria: * evidence of progressive disease in the above categories evaluated by standard tumor staging. * histologically confirmed diagnosis. * failure of conventional anti- cancer modalities.despite optimal application of all relevant available anti- cancer modalities. * age between 3 and 75 years old. * liver function tests less than twice the normal, renal function no more than 20% reduction and white cell and platelets count no more than 30% reduction. * karnofsky performance status of 50% or greater * a written informed consent understood and signed by the patient and by a spouse, parent or guardian. in patients with gbm two signs will be required due to possible alterations of psych and understanding. exclusion criteria: * not fulfilling any of the above criteria * moribund patients or patients with life- expectancy \< 3 months * karnofksy performance status \< 50% * pregnant or lactating women * active local or systemic infections requiring treatment * patients receiving other investigational agents * history of allergy to egg ova-albumin. * co-morbidity or life- threatening clinical condition other than the basic cancer

Keywords: ndv metastatic refractory cancer progression-free survival recurrent
superficial cervical plexus block for postoperative chronic pain

Conditions: Neurosurgery

Summary: the incidence of postoperative chronic pain after craniotomy is high. postoperative chronic pain seriously affects patient's quality of life. compound local scalp nerve block is a good choice for analgesia after craniotomy. however, the scalp nerve block commonly cannot cover the area of suboccipital retrosigmoid approach craniotomy, leading to incomplete block. superficial cervical plexus block (scpb) is theoretically promising to solve the analgesia requirements of such surgical approach. at the same time, ultrasound guidance can not only accurately locate, ensure the effect of block and avoid accidental injury during puncture. the purpose of this study is to explore whether ultrasound-guided superficial cervical plexus block can safely and effectively reduce the incidence of chronic pain after craniotomy via suboccipital retrosigmoid approach.


Eligibility criteria:
inclusion criteria: 1. elective suboccipital retrosigmoid approach approach craniotomy; 2. age between 18 and 65 years; 3. american society of anesthesiologists (asa) physical status i-iii. exclusion criteria: 1. the patients or legal clients refuse to provide informed consent; 2. local infection; 3. preoperative impairment of consciousness and cognitive function; 4. uncontrolled hypertension; 5. inability to communicate; 6. allergies to experimental drugs; 7. history of drug abuse; 8. history of chronic headache; 9. aphasia and hearing impairment; 10. patients undergoing second craniotomy; 11. body mass index \ 35.0 kg/m2;

Keywords: cervical plexus block chronic pain neurosurgery
the additive anti-inflammatory effect of simvastatin in combination with inhaled corticosteroids in asthma

Conditions: Asthma

Summary: we hypothesize that simvastatin in combination with ics might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients

to determine the additive effect of simvastatin on airway inflammation in ics-treated patients with persistent asthma by measuring eosinophil counts in induced sputum

Eligibility criteria:
inclusion criteria: * he or she has fev1 \> 60% of predicted * he or she requires less than 1000 mcg daily of beclomethasone or equivalent exclusion criteria: * he or she had previous history of renal disease or serum creatinine more than 2 mg/dl * he or she had previous history of liver disease * she is pregnant or during lactation * he or she has already received statins or is allergic to statins or has developed myositis. * he or she has an asthma exacerbation and requires treatment with oral corticosteroids during the 3 months prior to the commencement of study entry.
effectiveness of integrated network for student psychosocial intervention, resilience, and education (inspire) on mental health outcomes among indonesian adolescents in bandung

Conditions: Adolescents; Health Knowledge; Mental Health; Health Literacy; Resilience; Depression; Anxiety; Parents; School Intervention

Summary: the inspire (integrated network for student psychosocial intervention, resilience, and education) intervention is an 8-week, school-based mental health program designed to enhance adolescents' mental health literacy and resilience while addressing symptoms of depression and anxiety. implementation is conducted by school counselors who undergo an intensive two-day training program. the intervention is supported by comprehensive curriculum materials including detailed lesson plans, activities, discussion prompts, and instructional slides featuring key concepts, visuals, and explanatory content. supplementary materials are developed for both participating adolescents and their parents. the study aims to: 1. evaluate the usability and feasibility of the inspire intervention within the school environment. 2. assess the intervention's effectiveness in improving: * primary outcome: mental health knowledge among adolescents * secondary outcomes: attitudes toward mental health, help-seeking behaviors, mental health literacy, resilience, and symptoms of depression and anxiety among adolescents * secondary outcomes: mental health knowledge, attitudes, help-seeking behaviors, and mental health literacy among parents 3. explore the experiences of intervention participants (both adolescents and parents) against the control group to develop comprehensive insights into the psychosocial intervention's impact. the research hypothesis proposes that the inspire intervention group will demonstrate significantly higher scores in mental health knowledge, more positive attitudes toward mental health, increased help-seeking behaviors, enhanced mental health literacy, and greater resilience, while simultaneously showing reduced symptoms of depression and anxiety compared to the control group receiving standard care. these outcomes will be measured immediately following the intervention (post-test 1) and at one-month follow-up (post-test 2).


Eligibility criteria:
inclusion criteria: the inclusion criteria for adolescents are as follows: * unmarried, 13-15 years old, school-going, healthy adolescents enrolled in an indonesian public junior high school * able to read, understand, and converse in bahasa indonesia. the inclusion criteria for parents are as follows: * the biological father, mother, or an adult who fulfils a parental or guardian role for the participating adolescent * able to understand and communicate in bahasa indonesia. exclusion criteria: * adolescents who are working, clinically diagnosed with severe mental disorders, such as schizophrenia or psychosis, at high risk for mental health disorders (e.g., teenage pregnancy), or are cognitively impaired will be excluded. * parents with severe mental disorders or cognitive impairment that may hinder participation will be excluded.
machine learning for reclassification of obesity

Conditions: Obesity

Summary: the goal of this study is to employ or develop computational modeling techniques for the precise reclassification of obesity into subgroups. clinical features, risks of noncommunicable diseases, as well as weight loss effects of bariatric surgery will also be studied and compared within the subgroups.


Eligibility criteria:
inclusion criteria: 1. patients with overweight/obesity 2. patients with normal weight as controls exclusion criteria: 1. had ever been performed with a bariatric surgery before the study's first visit is scheduled; 2. had taken exogenous insulin, medication that affects glucose metabolism, or uric acid drugs currently; 3. being diagnosed with type 1 diabetes, secondary diabetes, hereditary disease, or severe disease (e.g. malignant tumor, heart failure, liver failure, etc.); 4. in gestation of lactation; 5. did not have the complete data for model; 6. for normal-weight controls, patients with diabetes or hyperuricemia were excluded.

Keywords: obesity machine learning metabolic classification clustering bariatric surgery
dmt310-001 topical in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the objective is to evaluate the tolerability, safety, and efficacy of dmt310 topical powder mixed with diluent in male and female patients with moderate to severe facial acne vulgaris.


Eligibility criteria:
inclusion criteria: * patient is male or non-pregnant female at least 18 years of age. * clinical diagnosis of moderate to severe acne vulgaris as determined by: investigator's global assessment (iga) at randomization patient has at least 20 but not more than 50 inflammatory lesions on the face patient has at least 20 but not more than 100 noninflammatory lesions on the face * patient is willing to apply the investigational product as directed * patient is willing and able to comply with the protocol exclusion criteria: * patient is pregnant or planning to become pregnant * patient is taking a topical therapy on the face which may affect the patient's acne
a multiple dose study of td-1211 in healthy volunteers and patients with opioid-induced constipation

Conditions: Healthy; Opioid-induced Constipation

Summary: the purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of td-1211 in healthy subjects and activity in subjects with opioid-induced constipation (oic).


Eligibility criteria:
inclusion criteria: * males and females between 18 and 65 years of age, inclusive * healthy subjects and subjects with documented oic on stable opioid regimen * willingness to stop all laxatives throughout the oic screening and treatment period exclusion criteria: * any clinically significant finding in healthy subjects * have participated in another clinical trial of an investigational drug 30 days prior to screening * history of chronic constipation prior to opioid therapy in oic subjects * active medical disorders associated with diarrhea or intermittent loose stools in oic subjects

Keywords: healthy subjects
helium 4 optically pumped magnetometers : a new generation of sensors for high speed functional brain imaging

Conditions: Normal Subject; Patient With Pharmaco-resistant Epilepsy

Summary: our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (opm he4) to record brain magnetic activities. the investigator will record 1) normal subjects stimulated with visual, auditory, somesthesic and motor stimuli and 2) epileptic patient. the investigator will compare the signal to noise ratio of the normal or pathological activities between classical meg sensors and our opm he4 prototype.


Eligibility criteria:
inclusion criteria: volunteers: * age 18+ * right handed * medical insurance * strongly motivated to participate to the study * signed informed consent for the study * no previous neurology or psychiatric pathologies * no major cognitive deficit and able to understand the instructions patients: * age 18+ * right handed * medical insurance * strongly motivated to participate to the study * signed informed consent for the study * no previous neurology or psychiatric pathologies (except epilepsy) * epilepsy evolving during at least two years * no major cognitive deficit and able to understand the instructions exclusion criteria: volunteers: * age \ 60 * previous neurology or psychiatric pathologies * child bearing women * subject having one of the following mettalic parts : * (pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve) * claustrophobia woman with a positive pregnancy test during the inclusion. patients: age \ 60 * previous neurology or psychiatric pathologies except epilepsy * child bearing women * subject having one of the following mettalic parts : * (pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve) * claustrophobia woman with a positive pregnancy test during the inclusion.

Keywords: meg opm epilepsy normal brain activity
digital device reading skin prick test

Conditions: Allergy Skin Prick Test Reading

Summary: skin prick tests (spts), or intraepidermal tests, are the first diagnostic approach for people with a suspected allergy. spts are very simple, safe and quick. they are cheap tests and are very useful as a screening test for allergy, especially in diseases like bronchial asthma, rhinoconjunctivitis, food/drug allergy and anaphylaxis. together with the clinical history, spts allow to draw conclusions on allergies based on the sensitization pattern. nevertheless, the technique itself has evolved very little and continues to be performed entirely manually. this has a few drawbacks that limit the utility of the tests, in many cases limiting them to a purely qualitative assessment. in comparison to standard practice (manual measurement), the digital skin test reading device nexkin dspt can provide the following benefits for project participants: automates and digitizes the test reading, provides test results in digital format, reduces variability and subjectivity and greater consistency of diagnosis, reduces manual tasks allowing health professionals providing quantitative instead of qualitative results and avoiding potential human errors and allows a faster workflow, resulting in shorter patient visits. the aim of this study is to validate the clinical utility of the electromedical skin test reading device nexkin dspt regarding its use in allergology clinics for the reading of skin prick allergy tests. the overall purpose of the study is to determine the sensitivity and specificity of skin prick tests (spt) performed using the current practice of the fully manual spt procedure and those performed using the nexkin spt dspt (digital) procedure and to compare the sensitivity and specificity of both methods.


Eligibility criteria:
inclusion criteria: patients who will undergo skin prick tests with panels of aeroallergens and/or foods. over 18 years of age. the patient or their representative has given consent to participate in the study. the patient must not have taken an antihistamine in the last 5 days. exclusion criteria: patients who are evaluated by more than 40 prick tests. patients who have taken an antihistamine within the previous 5 days. patients who are being treated with antidepressants or other drugs with an antihistamine effect. patients who suffer severe atopic dermatitis with forearm involvement. patients with dermographism. patients who are evaluated by intradermal testing. pregnant women or women suspected to be pregnant. vulnerable patients
evaluation of the incidence of palatal fistula in furlow double-opposing z-plasty vs. two-flap palatoplasty for cleft palate repair

Conditions: Fistula of Soft Palate (Disorder)

Summary: evaluation of the incidence of palatal fistula in furlow double-opposing z-plasty versus two-flap palatoplasty for cleft palate repair.

up to 6 hours before the scheduled arrival time, formula-fed babies may be given formula. up to 4 hours before the scheduled arrival time, breastfed babies may nurse. up to 2 hours before the scheduled arrival time, give only clear liquids. clear liquids include water, pedialyte®, kool-aid® and juices you can see through, such as apple or white grape juice. in the 2 hours before the scheduled arrival time, give nothing to eat or drink. induction of general anaesthesia will be administered followed by local anaethesia. then, surgical prodecure will be done either following the conventional two flap palatoplasty technique or the furlow double-opposing z-plasty technique.

Eligibility criteria:
inclusion criteria: 1. age of repair from 9 to 12 months. 2. isolated cleft palate 3. operation time should nearly be the same for all patients 4. surgical skills done by same surgeon 5. both sexes exclusion criteria: 1. patients with hypoplasia of palatal tissue. 2. patients with associated anomalies. 3. patients with associated syndromes. 4. other types of cleft palate.
early phase study comparing the effectiveness of a dairy product with the reference treatment aequasyal® on dry mouth symptoms in patients suffering from xerostomia caused by psychotropic medications.

Conditions: Xerostomia

Summary: dry mouth symptoms mostly occur as drug side-effects. available products such as saliva substitutes are disappointing (bad taste, poor efficiency). the hypothesis stems from the "empirical" observations that many patients alleviate dry mouth symptoms by the consumption of dairy products. through its composition, the dairy product in itself provides relief for the patient, due both to its physical and biochemical properties, which could explain these observed improvements, and to elements related to the phenomena of consumption of food as an alternative to medication. in the latter case, hedonism takes on a role which has not been previously assessed. initial work undertaken with the department of applied research at the national dairy industry school (enil) led to the prototyping of a new milk product, to qualify and adapt a product with a "health benefit" in patients suffering from xerostomia. this dairy product has specific taste, texture and lubrication properties and will be tested in a randomized controlled cross-over study for its efficiency and acceptability versus a reference product (aequasyal ®, oxidized glycerol triester) on a group of 32 patients at dijon and at besançon university hospitals. this way of combatting xerostomia at the interface of patients' diet, such as it is proposed here, could help improve their quality of life, minimize harmful effects (infection, decay) and promote adherence to treatments which are responsible for xerostomia.


Eligibility criteria:
inclusion criteria: * patients over 18 years old * patients seen in the psychiatry department requiring the prescription of psychotropic drugs (antidepressants anxiolytics) for over 6 weeks * patients complaining of xerostomia * patients having not taken a palliative therapy against xerostomia for at least 2 weeks * patients having signed a free and informed consent form * patients affiliated to a social security system exclusion criteria: * patients suffering from psychotic illness * patients suffering from sjogren's syndrome * patients having been treated by radiation therapy for head or neck cancer * patients having stopped a palliative therapy against xerostomia for less than 2 weeks * patients under 18 * pregnant or breastfeeding women * incapacitated adults * patients placed under tutorship or curatorship * patients under judicial protection * patients suffering from milk allergy or lactose intolerance

Keywords: xerostomia, saliva, iatrogenic oral dryness, dairy product
clinical study of qingpeng ointment in treating shoulder syndrome during rehabilitation period of cerebral hemorrhage

Conditions: The Efficacy of Qingpeng Ointment

Summary: a randomized, controlled study is conducted. 120 patients with post-stroke shoulder-shoulder syndrome who meet the inclusion criteria are randomized into treatment group and control group, 60 patients in each group. the treatment group is treated with qingpeng ointment. the goal of this trial is to verify the clinical efficacy of tibetan medicine qingpeng ointment in improving post-stroke shoulder-hand syndrome, and to investigate its effect on pain level, swelling degree, hand movement function, activity and activities of daily living.


Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria for stroke; 2. meet the diagnostic criteria for shoulder-hand syndrome, stage i 3. the course of disease is between 15 days and 6 months; 4. consciousness, no serious cognitive impairment, with examination and treatment; 5. age between 20 and 80 years old; 6. sign the informed consent form and volunteer to participate in the study. exclusion criteria: 1. repeated stroke patients or shoulder-hand syndrome patients with repeated attacks or exacerbations; 2. the course of stroke is \>6 months; 3. those with serious heart, liver and kidney diseases and moderate to severe infections; 4. unconsciousness or a combination of incompetent cognitive impairment and complete aphasia. 5. take painkillers or other treatments that treat shoulder pain.

Keywords: qingpeng ointment shoulder syndrome rehabilitation period of cerebral hemorrhage