Kornimate/medical-research-clean huggingface dataset:
the video-based exercise program in degenerative meniscus tears

Conditions: Degenerative Disease; Meniscus Tear; Knee Pain Swelling

Summary: this randomized-controlled trial aims to investigate the efficacy of a video-based exercise program in patients with degenerative meniscus tears.

to investigate the efficacy of a video-based exercise program, voluntary patients with degenerative meniscus tears, aged between 40 and 65 years, will be randomly divided into two groups: the video-based exercise (vbe) group and the standard exercise (se) group. interventions will be applied for 16 sessions (twice a week for eight weeks). the patients will be assessed at baseline and the end of the 8-week intervention. the pain during activity, at rest, and night will be assessed with the visual analog scale (vas). the active range of motion will be evaluated with a digital goniometer. isometric muscle strength will be measured with a handheld dynamometer. the knee injury and osteoarthritis outcome score (koos) will evaluate the functional status and symptoms. the western ontario meniscal evaluation tool (womet) will assess health-related quality of life.

Eligibility criteria:
inclusion criteria: * being aged between 40 and 65 years * having the degenerative meniscus tear in at least one knee * having body mass index in the range of 18-30 kg/m2 * feeling the pain that lasts for at least 2 months * having grade 1 or grade 2 degenerative meniscal tear diagnosed by an orthopedic specialist according to the mri results * having the activity level is between 1 and 5 according to the tegner activity scale * having the ability to read and write turkish exclusion criteria: * having undergone arthroscopic partial meniscectomy surgery due to degenerative meniscal tear * participating in a physiotherapy program for degenerative meniscal tear in the last 12 weeks * have received steroid injections in the last 6 months * accompanying conditions such as injury to the surrounding ligaments, congenital anomaly in the affected knee, coxarthrosis and spinal stenosis * presence of any systemic disorder that may affect assessment parameters * failure to cooperate with assessments * any vision or hearing problem that would prevent them from adapting to the assessment
gemox combined with targeted therapy and immunotherapy for patients with advanced cholangiocarcinoma

Conditions: Cholangiocarcinoma

Summary: the clinical trial is designed to evaluate the safety and efficacy of gemox combined with targeted therapy and immunotherapy for patients with advanced cholangiocarcinoma, and screen the potential biomarkers


Eligibility criteria:
inclusion criteria: * male or female, 18 years old ≤ age ≤ 70 years old * ecog ps scores 0-1 * expected survival time \> 12 weeks * advanced cholangiocarcinoma confirmed by histopathology and/or cytology, locally advanced (inoperable) or distant metastasis, and with at least one measurable lesion that has not been locally treated (per recist 1.1 criteria) * not received any previous systemic or local treatment for the tumor * sufficient organ and bone marrow function exclusion criteria: * suffered from other malignant tumors in the past 5 years (except radical basal cell carcinoma of the skin squamous carcinoma of the skin and/or radical resected carcinoma in situ) * ampullary tumor * received treatment from other clinical trials within 4 weeks before the first dose * received any anti-pd-1 antibody, anti-pd-l1/l2 antibody, anti-ctla4 antibody, or other immunotherapy * suffered from severe cardiovascular disease within 12 months before enrollment, such as symptomatic coronary heart disease, congestive heart failure ≥ grade ii, uncontrolled arrhythmia, and myocardial infarction * uncontrollable pleural effusion, pericardial effusion or ascites * use steroids or other systemic immunosuppressive therapies 4 weeks before enrollment * allergic reactions to the drugs used in this study * hiv antibody positive, active hepatitis b or c (hbv, hcv) * known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation * other conditions that the investigator deems inappropriate for enrollment
national registry and blood bank of patients with liver cancer

Conditions: Liver Cancer

Summary: rationale: gathering health information about patients with liver cancer over time may help doctors learn more about the disease and may help the study of cancer in the future. purpose: this clinical trial is developing a national registry and blood bank of patients with liver cancer.

objectives: * evaluate etiologic factors associated with hepatocellular carcinoma (hcc) in different ethnic groups and in different parts of the united states by developing a national registry of hcc patients. * survey stage and potential treatability of hcc patients referred to vanderbilt university hospital. * establish a serum repository for registry patients with samples to be used for future studies of the pathogenesis of chronic liver disease and hcc and for developing better diagnostic tests. outline: this is a multicenter, cross-sectional database study. data are collected on patients diagnosed with hepatocellular carcinoma at vanderbilt university medical center and at other participating hospitals or liver transplantation centers around the country for inclusion in a national registry of liver cancer patients. registry data are collected at baseline and then every 6 months for up to 5 years. the data are derived from investigator interviews with patients and from medical chart review of routine medical care provided during the course of the study. data are collected from all study sites and entered into a master database that includes information on patient demographics, diagnoses and staging details, treatment history, results of laboratory studies, and patient outcomes. information derived from the registry is available to investigators at all study sites. patients in the registry also undergo blood collection at baseline. blood samples are stored in a serum repository for evaluation in future studies related to liver disease, viral hepatitis, and liver cancer. a biological marker that may be analyzed is squamous cell carcinoma antigen immune complex (scca-ic). projected accrual: a total of 1,500 patients will be accrued for the vanderbilt university medical center study and up to 2,000 patients for the national study.

Eligibility criteria:
inclusion criteria: * diagnosis of hepatocellular carcinoma at a participating institution exclusion criteria: * none

Keywords: adult primary hepatocellular carcinoma advanced adult primary liver cancer localized resectable adult primary liver cancer localized unresectable adult primary liver cancer recurrent adult primary liver cancer
reverse shoulder arthroplasty with or without concomitant latissimus and teres major transfer for shoulder pseudoparalysis with teres minor dysfunction

Conditions: Osteoarthritis of the Shoulder

Summary: the overall objective of this study is to compare the clinical benefit and safety of two different surgical techniques of primary reverse total shoulder arthroplasty for the treatment of shoulder pseudoparalysis from chronic rotator cuff disease with associated teres minor dysfunction. the first surgical technique includes a concomitant latissimus and teres major transfer (transfer group) and the second technique does not include a concomitant latissimus and teres major transfer (control group).


Eligibility criteria:
inclusion criteria: * shoulder pseudoparalysis due to chronic rotator cuff dysfunction with or without glenohumeral arthritis. * chronic rotator cuff tear with severe retraction, atrophy, fatty infiltration. * active forward elevation of less than 90 degrees * teres minor dysfunction * positive lag and hornblower sign * grade 2 or greater fatty infiltration of the teres minor and infraspinatous seen on mri * able to attend scheduled office visits * meet all criteria to have a latissimus and teres major transfer exclusion criteria: * revision arthroplasty * previous shoulder infection * neuro-muscular disorder (ie: parkinson's) * advanced dementia

Keywords: reverse total shoulder
safety and immune response of covid-19 vaccination in patients with chronic liver diseases

Conditions: Liver Diseases; Covid19; Adverse Reaction to Vaccine

Summary: on 11 february 2020, the international committee for the classification of viruses named the disease caused by saｒs-cov-2 infection in humans as the new coronavirus pneumonia (coronavirus disease 2019, covid-19). due to the characteristics of liver microcirculation disturbance and immune function disorder in patients with chronic liver diseases (such as immune liver disease, chronic hepatitis c, liver cirrhosis, liver cancer, etc.), those patients has a higher risk of infection than the general population during the epidemic period. more attention should be paid to personal protection and disease prevention. vaccination of covid-19 vaccine can effectively prevent covid-19 virus infection and delay or prevent patients from developing into critical illness and reduce mortality. to evaluate the safety and effectiveness of covid-19 vaccine in those patients with chronic liver diseases, and to guide the covid-19 vaccination more scientifically, reasonably and effectively, this study was carried out.

due to the characteristics of liver microcirculation disturbance and immune function disorder in patients with chronic liver diseases (such as autoimmune liver disease, chronic hepatitis c, liver cirrhosis, liver cancer, etc.), those patients has a higher risk of infection than the general population during the epidemic period. more attention should be paid to personal protection and disease prevention. vaccination of covid-19 / influenza vaccine can effectively prevent covid-19 / influenza virus infection and delay or prevent patients from developing into critical illness and reduce mortality. the safety and effectiveness of covid-19 / influenza vaccine in this population were evaluated in order to play a scientific and theoretical supporting role in guiding covid-19 vaccination more scientifically, reasonably and effectively. the samples of this study were collected and tested in the second affiliated hospital of chongqing medical university. patients with contraindications for vaccination will be excluded. the detected indexes included blood routine test, liver function, covid-19 antibody titer, antibody duration and other indexes of healthy people (control group) and patients with chronic liver disease before and after vaccination ( 1, 3, 6, 12 months after vaccination). the adverse reactions related to the vaccine were recorded.

Eligibility criteria:
inclusion criteria: 1. healthy group were as follows: no history of hepatitis, no history of liver cirrhosis, no history of liver cancer and receiving the whole-course covid-19 vaccination. 2. patients with chronic liver disease diagnosed clinically or pathologically and receiving the whole-course covid-19 vaccination. exclusion criteria: 1. patients previously diagnosed or with a history of contact with confirmed cases 2. patients with contraindications for vaccination.
checking the usability of a virtual reality system in children with brain injury

Conditions: Acquired Brain Injury

Summary: the purpose of this study is to check the usability of virtual reality (vr) video capture projected system in children with acquired brain injury(abi)and comparing their performance to the performance of normally developing children. the trial shall include 15 subjects in each group, aged 6-12 years old. abi subjects are hospitalized at the hospital's pediatric rehabilitation department each subject will experience 3 different virtual environments. the subjects in the trial group will practice 3 experiences (3 times in 3 different days) during a period of a week to 10 days, to check the practice effect.in addition, all subjects will be tested in three tests: "pedi" - to evaluate the functional abilities of daily living (dressing, eating...),the "melbourne assessment" - to evaluate functional movements of upper extremities, and the tea-ch - to evaluate different attention abilities. performance correlations will be tested between these tests and the performance in the vr first experience.

the purpose of this study is to check the usability of virtual reality (vr) video capture projected system in children with acquired brain injury(abi) comparing their performance with the performance of normally developing children, matched by age, gender,sector and parents' education. subjects' age: 6 - 12 years old. the trial shall include 15 subjects in each group. abi subjects are hospitalized at sheba hospital's pediatric rehabilitation department. each subject will experience 3 different virtual environments. the subjects in the trial group will practice 3 experiences (3 times in 3 different days) during a period of a week to 10 days, to check the practice effect. in addition, all subjects will be tested in three tests: "pedi" - to evaluate the functional abilities of daily living (dressing, eating...),the "melbourne assessment" - to evaluate functional movements of upper extremities, and the tea-ch - to evaluate difference attention abilities. correlations between those tests to the performance in the vr experiences will be checked with pearson's statistical correlation tests. the differences between the trial group (abi children) and the control group will be checked with independent t-tests.

Eligibility criteria:
inclusion criteria:(trial group) * acquired brain injury as a result of brain tumor excision intervention, traumatic brain injury, infection, vascular disorders, metabolic disorders or anoxia. * ability to move at least one of the upper extremities against gravity in a partial range of motion (mmt: -3) exclusion criteria: (trial group) * significant visual limitations * premorbid, progressive mental disorder or neurological injury * premorbid learning disability inclusion criteria (control group): * healthy subjects exclusion criteria (control group): * developmental disorders * significant medical problems * neurological disorders

Keywords: virtual reality abi projected system
factors affecting timing of hypothyroidism following radioactive iodine therapy patients with graves disease

Conditions: Radioactive Iodine-Induced Hypothyroidism in Graves Disease Patients

Summary: the purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after rai therapy in graves' disease.

hyperthyroidism is a clinical syndrome caused by increased thyroid hormone in the blood, it can lead to multiple complications, including cardiac, hepatic, and hematologic system complications. more than 80% of hyperthyroidism are caused by graves' disease (gd). 3% of women and 0.5% of men may suffer gd in their lifetime \[1\]. radioactive iodine (rai) therapy is an important treatment option for graves' disease (gd), the main side effect of rai treatment is hypothyroidism, and the factors resulting in hypothyroidism are still controversial \[2\]. male gender, smaller thyroid weight, higher thyroid-stimulating hormone, and smaller thyroid volume are suggested to be the main risk factors for early hypothyroidism \[2\]-\[3\].

Eligibility criteria:
inclusion criteria: 1. graves' disease patients after one year of rai therapy . 2. suppressed serum thyrotropin (tsh) \ 6.5 pmol/l , free thyroxin ft4 \>22.7 pmol/l . exclusion criteria: 1. patients with other causes of hyperthyroidism , such as toxic multinodular goiter and single toxic adenoma 2. thyroid cancer 3. recurrent gd 4. previous thyroid surgery 5. patients can't complete the follow -up within 6 months.
short-course high-dose prednisone and dexamethasone in children with itp

Conditions: Immune Thrombocytopenia; Glucocorticoids; Child, Only

Summary: comparison of the efficacy and safety of short-course high-dose prednisone and dexamethasone in the treatment of children with newly diagnosed immune thrombocytopenia (itp)


Eligibility criteria:
inclusion criteria:subjects enrolled in this study must meet all of the following criteria: 1. meet the itp diagnostic criteria, within 3 months of the first diagnosis 2. age \> 28 days and ≤ 14 years old 3. untreated plt\<20×109/l, or plt\<30×109/l after 1 week of intravenous gamma globulin (ivig) treatment 4. have signed the informed consent exclusion criteria:anyone who has any of the following conditions will not enter the clinical study: 1. intracranial hemorrhage or severe gastrointestinal or urinary tract hemorrhage requiring emergency treatment, such as simultaneous use of platelet transfusion and thrombopoietic drugs (recombinant human thrombopoietin, eltrombopag, etc.) 2. received glucocorticoid therapy within 6 months 3. menstrual female children 4. patients with underlying diseases such as tumor diseases, autoimmune diseases or genetic diseases 5. patients who have received radiotherapy and chemotherapy 6. there are contraindications to the use of glucocorticoids (hypertension, glaucoma, peptic ulcer, etc.) 7. there are any significant abnormal coexisting diseases or mental illnesses that affect the patient's life safety and compliance, and affect informed consent, research participation, follow-up or interpretation of results
snuff-box deep palmar arch artery versus radial angiography

Conditions: Ischemic Heart Disease

Summary: angiography is a common diagnostic and therapeutic procedure in patients with acute coronary syndrome (acs). the complications are variable between mild self-limited complications to severe life-threatening complications which need early interventions. new angiographic methods are associated with variable complications. death, myocardial infarction, and stroke are among major angiography complications. in addition, some local complications including bleeding at the site of insertion, infection, arteriovenous fistula, pseudoaneurysm, and thrombosis is reported after angiography. radial and femoral methods are common angiographic methods. its shown that radial method is associated with less complications and patients need shorter duration of hospitalization. radial artery thrombosis is common complication of radial angiography. however, the prevalence is between 5 to 19 percent but often it is not clinically important. risk of ischemia due to thrombosis is low because of blood flow in radial and ulnar and collaterals. in patients with incomplete palmar arch this is important and may cause ischemia. the aim of this study is to compare the outcomes of coronary angiography using snuff-box deep palmar arch artery and radial artery in patients attending angiography center of shahid mohammadi hospital in bandar abbas in 2017.


Eligibility criteria:
inclusion criteria: * indication of coronary artery angiography confirmed by a cardiologist * accepting to sign the written informed consent exclusion criteria: * no follow up visit after one-month period
efficacy and safety study of dysport® used for migraine prophylaxis

Conditions: Migraine

Summary: the purpose of this study is to evaluate the efficacy of botulinum toxin type a (dysport®) injections into pericranial muscles compared to placebo to prevent migraine attacks.


Eligibility criteria:
inclusion criteria: * patients having migraine without aura or with typical aura as defined by international headache society criteria * migraine attacks have been persisting for more than 1 year * 2 to 6 migraine attacks per month of at least moderate severity over the 3 months preceding the pre-inclusion visit * 2 to 6 migraine attacks of at least moderate severity during the screening period exclusion criteria: * non-migraine headaches such as tension-type headaches * migraine with prolonged aura, familial hemiplegic migraine, basilar migraine, migraine aura without headache, migraine with acute onset aura, ophthalmoplegic migraine, retinal migraine, complications of migraine * onset of migraine is after age of 50 * overuse of acute migraine medications (individuals who take medications for acute migraine more than 10 days per month) or have a history of drug or alcohol abuse
ehealth: second life impacts diabetes education & self-management

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to to develop and evaluate the feasibility, usability, and effect of participation in slides (a virtual diabetes community in second life) for providing interactive diabetes education, support, and resources.


Eligibility criteria:
inclusion criteria: * current duke endocrinology patient * are between 21 and 75 years old * are able to speak and read english * are computer literate (have used a computer for at least 6 months) * understand how to use the internet (have accessed the internet on at least 6 occasions) * have access to a computer with a non-dial-up internet connection in a private location (home) * are mentally capable of informed consent * are reachable by telephone * have no pre-existing medical condition(s) or severe diabetes related complications that would interfere with study participation (i.e., physical activity) or measures (e.g., renal failure, stage iii hypertension, severe orthopedic conditions or joint replacement scheduled within 6 months, paralysis, bleeding disorders, cancer, or receipt of pharmacologic doses of anti-coagulant medications \[warfarin\]) * are able to travel to duke university medical center (dumc) for follow-up appointments. exclusion criteria: -

Keywords: diabetes second life virtual community diabetes education diabetes support group
postoperative desogestrel for endometriosis related pain

Conditions: Endometriosis

Summary: endometriosis is one of the most common disease in reproductive aged women.surgical intervention has a significant symptoms relief. however, symptom recurrence is often after surgery. this study aims to determine the efficacy of desogestrel compared with placebo in pain symptom of symptomatic endometriosis patient undergo conservative surgery . the primary outcome measurement is pain score at 6 months after surgery.

after conservative surgery, the patients are randomized to desogestrel and placebo groups. vas pain score are compared after complete 6 months

Eligibility criteria:
inclusion criteria: * diagnoses endometriosis * plan conservative surgery * initial pain score at least 5 * voluntary to be the participant of this study with inform consent * no desired child bearing in 6 months exclusion criteria: * residual lesion after surgery which required further treatment * cannot participate complete 6 months after surgery * contraindication for desogestrel, paracetamol or ponstan * pregnant

Keywords: endometriosis desogestrel placebo