Kornimate/medical-research-clean huggingface dataset:
the effects of chiropractic in adults with colon cancer

Conditions: Colon Cancer Stage III; Colon Cancer Stage IV

Summary: the main objectives of this single-arm pilot trial are to investigate the feasibility of our protocol in terms of 1) recruitment, 2) adherence, 3) tolerability, 4) acceptability and 5) retention. we aim to recruit 20 participants with advanced colon cancer (stage 3-4) who will have assessments of their autonomic nervous system function, carcinoembryonic antigen (cea) levels, and patient-reported outcomes. thereafter, patients will be directed to a nearby field clinic to receive twice-weekly cervical assessments \& high-velocity, low-amplitude (hvla) cervical adjustments for a period of 6 weeks. re-assessments will be performed following 2 weeks and 6 weeks of chiropractic care.

after providing informed consent, individuals will undergo 6 weeks of chiropractic care. throughout these 6 weeks there will be three assessments (day 1, week 2, and week 6) that each include the following: 1. isometric hand grip 2. postural challenge 3. patient-reported outcome surveys 4. off-site blood draw for cea level testing (only day 0 and week 6) each assessment will consist of the following recordings: 1. electrodermal activity \[eda\] 2. impedance cardiography \[icg\] 3. electrocardiogram \[ecg\]

Eligibility criteria:
inclusion criteria: * males \& females 18 years of age or older * able to provide informed consent * diagnosed with stage 3 or stage 4 colon cancer and currently receiving standard of care with a medical doctor. exclusion criteria: * individuals with a known disorder resulting in syncope/fainting during postural changes (e.g., pots, orthostatic hypotension) * cancer has metastasized to the cervical spine * individuals who have had a serious injury or surgery to the head, torso, lower body within the past 6 months. * individuals with evidence or medical history of clinically significant psychiatric disorder like anti-social disorder, schizophrenia, or borderline personality disorder that is uncontrolled or untreated. * individuals who currently have pending health related legal litigation. * individuals with a known heart condition (e.g., arrhythmia) that could result in an aberrant electrocardiogram. * individuals with a pacemaker * individuals who are on short benzodiazepines which include midazolam \& triazolam * individuals with conditions that could result in neck instability such as rheumatoid arthritis. * individuals who do not present with a subluxation in the upper cervical region (c1/c2) at any point during the 6 weeks of chiropractic care. * individuals with a condition that may cause weak or brittle bones such as osteoporosis * since x-rays may be requested for care, participants who are pregnant will be excluded from the study.

Keywords: chiropractic colon cancer spinal manipulation autonomic nervous system cea patient reported outcomes
high-tone external muscle stimulation for pain reduction

Conditions: Chronic Radicular Back Pain; Lumboischialgia; Cervico Brachialgia

Summary: sciatica is a common pain problem that affects not only the patient but also constitutes a socioeconomic burden and thus affects the whole society. so far, current pharmacologic therapies are inadequate for many patients. therefore, we evaluated application of high-tone external muscle stimulation (htems) compared to transcutaneous electrical nerve stimulation (tens) on radicular pain associated with sciatica.

hospital patients (n=100) with chronic sciatica and stable oral analgesic regimen were included into this randomized controlled cross-over trial. each intervention was administered for a period of 45 min 5 times within 10 days, with a 3-day wash-out period before cross-over. health impairments had been assessed using the visual analog scales (vas) for radicular pain before and after intervention and differences in radicular pain between groups were analysed with the mann-whitney test.

Eligibility criteria:
inclusion criteria: * sciatica due to degenerative spine disorders * stable oral analgesic regimen exclusion criteria: * history of drug or alcohol abuse * cardiac pacemaker or defibrillator * pregnancy

Keywords: back pain sciatica electrotherapy htems tens
adjuvant chemotherapy plus codonopsis pilosula nnannf /placebo

Conditions: Pancreatic Carcinoma; Adjuvant Chemotherapy; Cancer-related Fatigue

Summary: pancreatic carcinoma patients got benefit from adjuvant therapy after radical surgery. gemcitabine combined with albumin-paclitaxel was recommended as the first-line regimen for adjuvant chemotherapy by nccn guidelines. the most common non-hematological adverse events associated with gemcitabine combined with albumin-paclitaxel treatment were fatigue (54%), followed by alopecia (50%), and grade 3 or higher adverse events were mainly granulocytopenia, leukopenia, fatigue, and peripheral nerve damage. cancer-related fatigue (crf) is the most common concomitant symptom in cancer patients, especially during chemotherapy, which has a negative impact on patients' work, social relationships, emotions and daily activities. therefore, it is of great clinical significance to improve crf in cancer patients. from the perspective of traditional chinese medicine, crf patients will have a series of syndromes such as low function of viscera, general weakness, and emaciation, which last for more than 2 weeks and affect patients' physiology and psychology at the same time. codonopsis pilosula nnannf can restore the postoperative immune ability of patients as soon as possible after chemotherapy.


Eligibility criteria:
inclusion criteria: * patients with pancreatic adenocarcinoma was confirmed by pathology after radical resection. * patients received adjuvant chemotherapy after surgery, and the chemotherapy regimen was gemcitabine combined with albumin paclitaxel. * ecog score was less than 2. * the expected survival time was more than 3 months. exclusion criteria: * patients were received radiotherapy, chemotherapy within 4 weeks. * pregnant and lactating women. * patients were known to be allergic to the regimen.
practical approaches to exercise in moms

Conditions: Body Weight

Summary: this project aims to test the feasibility of a practical physical activity intervention for postpartum women, incorporating the use of body weights worn during typical daily activities.

we are piloting a 3-arm, unblinded, randomized controlled trial in postpartum women; with 10 participants in each study group. women will be recruited at 2-6 months postpartum, with the intervention lasting through 12 months postpartum. data collection will include:1) physical activity; 2) maternal body composition; 3) questionnaires to assess:motivation to adopt healthy behaviors, body attitudes, infant feeding practices; 4) process evaluation to assess: likes and dislikes about the intervention program, suggestions for improving the intervention, reasons for leaving the study. the proposed study time period is 6 months for study recruitment, 18 months to carry out the study, and 6 months for data analysis (total 2 years).

Eligibility criteria:
inclusion criteria: * 2-6 months postpartum women exclusion criteria: * premature birth * history of serious illness * medically incapable of low-intensity exercise * currently taking medications that cause weight loss

Keywords: postpartum physical activity
does moderate physical activity in hemodialysis patients reduce inflammation?

Conditions: End-stage Renal Disease; Hemodialysis

Summary: the purpose of this study is to observe a potential benefit of moderate physical activity by using bed mounted cycles during hemodialysis treatment sessions on inflammatory markers in the blood of patients with end-stage renal disease (esrd).

patients with esrd on chronic hemodialysis patients frequently have elevated markers of inflammation (e.g., serum crp values) and accumulation of proinflammatory monocyte populations in the circulation. the level of inflammation is highly predictive for cardiovascular disease and mortality. physical activity has been shown to improve dialysis efficacy by improving the elimination of retention solutes. in healthy individuals, sports activity influences inflammatory immune parameters. the study will observe the influence of moderate physical activity (using a bed mounted cycle for 30min during dialysis thrice weekly) on circulating monocyte subpopulations and inflammatory proteins over a 9 month period in 16 chronic hemodialysis patients.

Eligibility criteria:
inclusion criteria: * chronic hemodialysis treatment for at least three months * three dialysis sessions per week * good general clinical condition * stable hemodynamics during the most recent three dialysis sessions exclusion criteria: * conditions making the patient unable to use the bed mounted cycle (amputations, joint disease etc) * clinically obvious acute infections * active malignancy * pathologic results of spiroergometry or echocardiography that imply an elevated risk of participation * myocardial infarction within the last 12 weeks * uncontrolled arterial hypertension * uncontrolled diabetes mellitis with frequent hypoglycemia * unability to understand and consent the protocol

Keywords: inflammation cardiovascular disease
high definition endoscopy and optic enhancement endoscopy in gastric neoplasia: a prospective study

Conditions: Gastric Neoplasia

Summary: the aim of the study is to evaluate the diagnostic value of high definition endoscopy and optic enhancement in gastric neoplasia.


Eligibility criteria:
inclusion criteria: * patients with dyspeptic symptoms and aged 40 years or older * or patients with helicobacter pylori infection, or histologically verified gastric intestinal metaplasia or atrophic gastritis * or patients with family history of gastric cancer exclusion criteria: * presence of gastrectomy, acute gastrointestinal bleeding, or known gastric neoplasia * presence of conditions unsuitable for endoscopy procedure including coagulopathy, impaired cardiopulmonary function , pregnancy or breastfeeding * inability to provide informed consent
evaluation of lung deposition of aerosol via hfnc in healthy adults

Conditions: Healthy

Summary: the aerosol associated with noninvasive ventilation (niv) and high flow therapy with nasal interface have been employed in an attempt to relieve respiratory distress and optimize the deposition of drugs by inhalation. some studies report the effects of niv association with fogging in healthy subjects, asthmatics and copd 7.8, but studies evaluating the association between high flow nasal mist interface and therapy are scarce and most are found in vitro and animal models. the objective of this study is to evaluate the deposition of the aerosol scintigraphy using the high flow nasal interface system with vibrating mesh nebulizers using in healthy adults.


Eligibility criteria:
inclusion criteria: * the study included healthy individuals of both sexes, * between 18 to 65 years, * without history of lung disease and forced vital capacity (fvc) or forced expiratory volume in the first second (fev1) higher or equal to 80% from predicted values, * ability to verbal commands understand and * willing to provide signed consent to participate in this study. exclusion criteria: * participants were excluded if there unable to understand and follow the procedures and were pregnant and unable to tolerate nebulization.

Keywords: nasal cannula inhalation devices
comparison of subjective outcomes and changes of ultrasonographic morphology of median nerves of mini-open and endoscopic carpal tunnel release in patients with idiopathic carpal tunnel syndrome

Conditions: Idiopathic Carpal Tunnel Syndrome

Summary: a few studies have shown that the mini-incision release technique decreases the pathologic swelling of the median nerve at the inlet of the carpal tunnel and increases the flattening ratio of the median nerve in the carpal tunnel. however, it is unknown whether the endoscopic release technique similarly reverses these pathological changes in the median nerve along the carpal tunnel in patients with cts compared with the mini-incision release. investigators therefore conducted the current study to compare the subjective outcomes and us-measured morphological changes in the median nerve in patients with cts who received either mini-incision or endoscopic release. investigators hypothesized that (1) subjective outcomes, as assessed by both the boston carpal tunnel questionnaire (bctq) symptom/function scores and the dash scores, would be similar 24 weeks after either mini-incision or endoscopic carpal tunnel release; (2) changes in the morphology of the median nerve at each level of the carpal tunnel, as measured under high-resolution us, would be similar 24 weeks after either mini-incision or endoscopic carpal tunnel release; and (3) morphological changes would be correlated with improvements in subjective outcomes 24 weeks after mini-incision or endoscopic carpal tunnel release.


Eligibility criteria:
inclusion criteria: * patients who are 20 years or older. * patients with idiopathic cts that was confirmed by electrodiagnostic tests * patients with idiopathic cts who were scheduled for carpal tunnel release exclusion criteria: * patients with a history of wrist-area fracture or dislocation * patients with previous carpal tunnel release * patients with associated cervical radiculopathy, cubital tunnel syndrome, thoracic outlet syndrome, diabetes mellitus, hypothyroidism, arthritis, or burger's disease * patients with cognitive impairment that affected the patient's ability to complete the questionnaires * patients with worker's compensation issues * patients with inadequate follow-up (i.e., less than 24 weeks post-operation)

Keywords: carpal tunnel syndrome
a study of pemafibrate in patients with nonalcoholic fatty liver disease (nafld)

Conditions: Non-Alcoholic Fatty Liver Disease

Summary: a multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of pemafibrate in patients with nonalcoholic fatty liver disease.


Eligibility criteria:
inclusion criteria: 1. patients show presence of hepatic fat fraction as defined by ≥ 10% on mri-pdff at screening 2. patients show presence of liver stiffness as defined by ≥ 2.5 kpa on mre at screening 3. patients have an alt above the upper limits of normal (30 iu/l for females and 40 iu/l for males) at screening 4. patients with nafld had to be age 20 years or older at written informed consent(icf) exclusion criteria: 1. current of significant alcohol consumption (significant alcohol consumption is defined as more than 210 g/week in males and more than 140 g/week in females, on average) 2. planned use of contraindicated medications from written icf to end of treatment. 3. bmi \< 22 kg/m2 at screening 4. uncontrolled diabetes mellitus as defined by a hba1c(ngsp) ≥ 8.0％ at screening 5. egfr \< 30 ml/min/1.73m2 or dialysis patient 6. cirrhosis 7. biliary obstruction 8. patients were excluded if they had evidence of other forms of liver disease shown by the following: * hepatitis b or hepatitis c * autoimmune hepatitis（aih） * primary biliary cirrhosis（pbc） * primary sclerosing cholangitis（psc） * drug-induced liver injury * hyperthyroidism, wilson's disease, hemochromatosis, alpha-1-antitrypsin disease 9. those with complicating malignant neoplasm or those judged to be at a high risk of recurrence 10. patients with contraindications to mri imaging 11. patients who gave 200 ml or more of blood within 1 month before the administration of the study drug, or 400 ml or more of blood within 4 months before the administration of the study drug 12. patients with a history of serious drug allergies (such as anaphylactic shock) 13. pregnancy, breast feeding, planned pregnancy 14. patients who were participating in another clinical study at the time of consent was obtained or who received study drugs other than the placebo less than 16 weeks before consent was obtained 15. patients who have previously been administered pemafibrate 16. patients who have been determined inappropriate by the investigator or subinvestigator
pediatric oncological orthopaedic reconstruction

Conditions: Bone Tumor; Bone Cancer

Summary: from the archives of the rizzoli institute all the children undergoing oncological reconstruction from 1991 to 2023 (approximately 400 patients). a review will be made of the medical records, radiological imaging, and histological data of these patients


Eligibility criteria:
inclusion criteria: * diagnosis of bone sarcoma * patients with available clinical and imaging data exclusion criteria: * at least one inclusion criteria not met
the psychophysiological effect of simulated and terrestrial altitude

Conditions: Hypoxia; Altitude Hypoxia; Altitude Sickness; Altitude; Mountain Sickness; Hypoxia, Altitude

Summary: the aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.

research has consistently shown that exposure to extreme environments (such as high altitude stays) may affect cognitive function. for logistical reasons and to control the experimental set-ups, most of these examinations are carried out in the laboratory. by testing under such controlled conditions, researchers can remove any co-foundational factors and isolate the cause of stress, thereby better understanding the mechanisms by which impairment can occur. however, when people are exposed to such environments in the "real world" (such as altitude), they often experience a number of other additional stressors at the same time, which can also affect their performance. surprisingly, however, little attention has been paid to the study of these additional stressors in combination. although the oxygen content remains constant at various altitudes (20.93%), the air pressure decreases exponentially as the altitude increases. as a result, the oxygen partial pressure in arterial blood and tissue is reduced (hypoxia), leading to a deterioration in both physical and cognitive performance. hypoxic conditions also alter the perception of pain, which may be particularly relevant for patients suffering from hypoxic conditions. according to the authors' knowledge, there is limited literature investigating and comparing simulated and real psychophysiological responses.

Eligibility criteria:
inclusion criteria: * healthy, adults aged 18 to 50 years * no cardiovascular disease and / or surgery * no surgery on the cardiovascular system. * no current injuries and / or pain * regular and adequate sleep * no terrestrial altitude of 1000 m exceeded last month (including flights) * no form of hypoxia exposed last month exclusion criteria: * age over 50 years * current injuries of any kind and / or pain * acute and / or chronic pain conditions known general diseases (e.g., diabetes mellitus) * fear of hypoxia * fear of heights or sensitivity to terrestrial altitude * regular use of medicines (also bought by yourself), except for contraceptives * cardiovascular diseases or abnormalities * anomalies of the blood analysis or ecg * psychological disorders * pregnancy / lactation

Keywords: hypoxia altitude physiology cognition
tacrolimus combined with low-dose prednisone for treatment of myasthenia gravis

Conditions: Myasthenia Gravis

Summary: this study is designed to evaluate the effectiveness and safety of tacrolimus combined with low-dose prednisone in the management of myasthenia gravis patients, compared to tacrolimus as initial immune monotherapy.

this is a single center, observational real-world study recruiting myasthenia gravis patients from neurology departments of xuanwu hospital, aiming to compare effectiveness and safety of 2 different inmunotherapy for mg. the study plans to recruit 160 mg participants and divides into 2 treatment groups according to physician's judgment and preferences of patients, one is combined immunotherapy group in which tacrolimus added with low-dose prednisone (0.25mg/kg/d), and the other is tacrolimus monotherapy group. both groups can be treated with pyridostigmine to relieve symptoms. patients are followed up at 1, 3 and 6 month after treatment initiation to assess the efficacy of both regimen. the primary outcome is the change of mg-adl scores. also, liver and renal functions are tested to monitor any side effects. patients' clinical records are uploaded to an online database.

Eligibility criteria:
inclusion criteria: * age ≥18 * clinical diagnosis of mg is confirmed based on typical clinical features of fluctuating muscle weakness, with at least 1 of the following supporting evidence: 1. positive clinical response to acetylcholinesterase inhibitor 2. positive achr-ab or musk-ab testing 3. decrement \>10% in repetitive nerve stimulations study (rns) or increased jitter on single-fibre electromyography (sfemg) * mgfa clinical classification: i - iv * baseline mg-adl ≥ 3 * disease course from onset to enrollment ≤ 12 months * cooperation to followup * written informed consent exclusion criteria: * initiation of immunosuppressant for mg prior to screening, including prednisone, methylprednisolone, azathioprine, methotrexate, cyclosporine a, mycophenolate mofetil, tacrolimus and cyclophosphamide * treatment of immunosuppressant for other concomitant disease 6 months prior to recruitment * rapid immunosuppressive treatments like intravenous immunoglobulin or plasma exchange 1 month prior to recruitment * thymectomy within 3 months prior to screening * concomitant chronic degenerative, psychiatric, or neurologic disorder that can cause weakness or fatigue * consciousness, dementia or schizophrenia * pregnancy or lactation, unwillingness to avoid pregnancy * uncontrolled hypertension or diabetes, liver or kidney dysfunction, cataract, severe osteoporosis, femoral head necrosis; hyperkalemia, hiv, acute or chronic infection * other conditions that would preclude participation

Keywords: myasthenia gravis treatment tacrolimus low-dose prednisone
(pakistan diabetes prevention program pdpp)

Conditions: Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score

Summary: the karachi-based pakistan diabetes prevention study aims to address key issues in the prevention of type 2 diabetes. approximately 20,000 people from four communities will be screened for diabetes risk factors using a non-invasive diabetes risk-score system. those found to be at increased risk will be given an oral glucose tolerance test. people who, after the oral glucose tolerance test, are identified as having prediabetes or normal but with risk factors such as raised bmi and/or history of hypertension will have the opportunity to take part in the pakistan diabetes prevention study lifestyle intervention. this consists of culturally adjusted preventive strategies focusing on diet and physical activity in real-life settings. another important aspect of this trial will be to assess the impact of urban planning on the prevalence of obesity and diabetes.

the aim of this study is to translate the life style intervention project to prevent diabetes into real life settings in karachi, pakistan, home to one sixth of the world's population.

Eligibility criteria:
inclusion criteria: -adult men and women between 30-64 years of age exclusion criteria: * diagnosed type 1 or type 2 diabetes * pregnancy or presence of chronic disease rendering survival for three years unlikely * any psychological or physical disability to interfere with participation in the study * ischemic heart disease

Keywords: ifg igtt