Kornimate/medical-research-clean huggingface dataset:
efficacy of teas on chronic pain and survival in patients undergoing hepatectomy

Conditions: Liver Cancer

Summary: this study is a further observation and follow-up of the patients enrolled in the registration number nct06341270 to further evaluate the efficacy of teas on postoperative chronic pain, quality of life and survival rate in patients undergoing hepatectomy.

this study is a further observation and follow-up of the patients enrolled in the registration number nct06341270 to further evaluate the efficacy of teas on postoperative chronic pain and survival in patients undergoing hepatectomy. patients who meet the enrollment criteria will be randomized 1:1 to either the transcutaneous electrical acupoint stimulation (teas）or the sham groups. in the teas group, the acupoints are bilateral neiguan (pc6), hegu (l14), yanglingquan (gb34), zusanli (st 36) and renying (st9) acupoints. patients will receive teas 30 min before anesthesia until being discharged from the post-anaesthesia care unit (pacu). the same treatment for 30 min will be performed on the 1st, 2nd and 3rd days after surgery. the stimulation intensity will be adjusted in accordance with the maximal level tolerated by each patient. patients in the sham group will receive electrode attachment but without stimulation. follow-up after discharge includes chronic pain, the impact of chronic pain on quality of life, the relapse-free survival, overall survival at 3 months and 6 months postoperatively.

Eligibility criteria:
inclusion criteria: age 18-80 years old; asa physical status classⅰ-ⅲ; patients scheduled for elective hepatectomy. exclusion criteria: have a history of epilepsy; rash or local infection over the acupoint stimulation skin area; pregnancy or breastfeeding; mental retardation, psychiatric, or neurological disease; inability to comprehend the numeric rating scale (nrs); implantation of a cardiac pacemaker, cardioverter, or defibrillator; chronic opioid use; metastases in other organs.
analysis of risk factors for surgical site infections in patients with acute abdomen at hospital of state university of haiti

Conditions: Surgical Site Infection; Post-Op Infection

Summary: the purpose of this study is to identify the risk factors associated with surgical site infection.

87 patients medical records from january 2018 to december 2020 will be analyzed to detect the risk factors linked to the occurence of surgical site infection. then the strength of their association with surgical site infection will be determined via multivariate analysis.

Eligibility criteria:
inclusion criteria: * female or male patients over 12 years of age. * admitted to the surgery department for acute surgical abdomen and having undergone surgery exclusion criteria: * patients who have undergone abdominal surgery for urological or gynecological pathologies * files with missing information on preoperative, operative and post-operative arrangements

Keywords: surgical site infection nnis index post-operative infection
mirna profile in aneurysmal subarachnoid haemorrhage

Conditions: Subarachnoid Hemorrhage

Summary: the investigators aim to investigate and understand the circulating mirna profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

1. the investigators aim to investigate the mirna classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage; 2. the investigators aim to investigate the corresponding circulating and csf mirna profiles.

Eligibility criteria:
inclusion criteria: aneurysmal subarachnoid hemorrhage patients within the first 72 hours or healthy volunteers exclusion criteria: previous neurological diseases such as stroke or dementia

Keywords: subarachnoid haemorrhage
trial of weaning by synchronized ventilation

Conditions: Neonatal Respiratory Failure

Summary: during assist control ventilation and pressure support ventilation (psv), the start of ventilator inflation is determined by the start of the infant's inspiratory effort. during psv, termination of inflation is determined by the level of the infant's inspiratory flow. in a randomized trial, no significant differences were found between assist control and pressure support ventilation with regard to the duration of weaning, time to successful extubation, work of breathing, rate of asynchrony and level of respiratory muscle strength.

objectives: to test the hypothesis that the duration of weaning would be shorter using assist control ventilation (acv) rather than pressure support ventilation (psv). to determine if any differences in the duration of weaning reflected differences in the work of breathing, the rate of asynchrony or the level of respiratory muscle strength. patients and methods: thirty-six infants, median gestational age 29 (range 24 to 39) weeks, were randomized to weaning by either acv or psv. the duration of weaning was recorded. at baseline (study entry), 24 hours after entering the study and immediately prior to extubation, the work of breathing was assessed by measuring the transdiaphragmatic pressure time product (ptpdi), thoracoabdominal asynchrony (taa) was assessed using respiratory inductance plethysmography and respiratory muscle strength measured by recording the maximal inspiratory pressure produced during an airway occlusion during crying (pimax). immediately prior to extubation, the level of active expiration was also assessed.

Eligibility criteria:
inclusion criteria: * ventilated neonates less than 14 days of age exclusion criteria: * congenital heart disease, hypoxic ischaemic encephalopathy

Keywords: neonate weaning assist control ventilation pressure support ventilation
the combined antibiotic therapy for carbapenem resistant klebsiella pneumoniae

Conditions: Antibiotic Resistant Infection

Summary: the infection of carbapenem resistant klebsiella pneumoniae (crkp) is increasingly serious.based on the early experimental basis and relevant research background,this study intends to separate and purify the crkp from the bronchoalveolar lavage fluid (balf) of the clinical patients.designed by checkerboard assay and time-kill assay(tka)，this study can explore the best combination therapy based on carbapenems.

1. collect the balf from patients diagnosed with crkp infection in surgical intensive care unit（sicu）of shanghai 10th people's hospital. 2. separate and purify the balf. divide each crkp into four treatment groups based on meropenem. 3.1 by checkerboard method and microdilution broth method,get the minimal inhibitory concentration (mics) of two antibiotics,then calculate the fractional inhibitory concentration (fic) index according to mic results. 3.2 observe the effect of two antibiotics on the growth of crkp by tka. 4.by the above two invitro experiments, analyze the data of the experimental results and get the best combination therapy based on carbapenems.

Eligibility criteria:
inclusion criteria: * age from 18 to 90. * infected with crkp firstly . exclusion criteria: * apache ii score \> 35 * vital signs are unstable * unable to tolerate fiberoptic bronchoscopy
prospective evaluation of electrocardiographic voltage changes and six minute walk test for predicting readmissions in heart failure (preemt-hf study)

Conditions: Heart Failure

Summary: purpose of the study: to identify whether electrocardiographic qrs voltage changes (between admission and pre-discharge) and pre discharge 6- minute walk test in patients admitted with acute heart failure can identify patients at risk for recurrent admissions for heart failure.

primary objective determine the ability of ekg voltage changes and pre discharge 6-minute walk test (6-mwt) to predict repeat heart failure hospitalization (hfh) in patients admitted with acute decompensated heart failure (adhf). secondary objectives 1. determine the ability of ekg voltage changes and pre discharge 6-mwt) to predict a composite of 1 year mortality and hfh in patients admitted with adhf. 2. determine the ability of proportionate pulse pressure, orthostatic blood pressure changes and pre discharge inferior vena cava (ivc) diameter by portable ultrasound to predict hfh and mortality

Eligibility criteria:
inclusion criteria: * patients \> 18 years of age, admitted with a diagnosis of adhf and fulfilling the following criteria: 1. evidence of systemic congestion (manifested by any 2 of the following criteria: jugular venous distension, edema, pulmonary rales, left ventricular s3, or radiographic evidence of pulmonary venous congestion) 2. elevated brain natriuretic peptide 3. need for at least 1 dose of intravenous loop diuretic exclusion criteria: * cardiogenic shock, acute coronary syndromes (patients with mild elevation in troponin related to heart failure will not be excluded), patients who are admitted for another principal problem and develop adhf in the hospital, pregnant females, end stage renal disease on hemodialysis, expected survival \< 6 months.

Keywords: heart failure
darbepoetin alfa with or without intravenous (iv) iron

Conditions: Anemia; Non-Myeloid Malignancies

Summary: to deterime the efficacy of 500 μg and 300 μg darbepoetin alfa administered subcutaneously (sc) on an every 3 weeks (q3w) schedule, and the effect of intravenous (iv) iron supplementation in the treatment of anemia in patients with non-myeloid malignancies who were receiving multicycle chemotherapy.


Eligibility criteria:
inclusion criteria: * active non myeloid malignancy(cies) including lymphocytic leukemias * received chemotherapy and expected to receive at least 8 additional weeks of cyclic cytotoxic chemotherapy * anemia due to chemotherapy (screening hgb \<or = 10.0 g/dl) * at least 18 years of age at screening exclusion criteria: * acute myelogenous leukemia (aml), chronic myelogenous leukemia (cml), or myelodysplastic syndromes (mds) * other underlying hematologic disorder, which could cause anemia, other than a non myeloid malignancy * active bleeding * severe, unstable, active chronic inflammatory disease (eg ulcerative disease, peptic ulcer disease, rheumatoid arthritis) * active, unstable systemic or chronic infection * planned elective surgery during the study where significant blood loss is expected * unstable angina, or uncontrolled cardiac arrhythmia * uncontrolled hypertension (diastolic blood pressure \> 100 mmhg) * history of pure red cell aplasia (prca) * history of deep venous thrombosis * known positive human immunodeficiency virus (hiv) test or acquired immune deficiency syndrome (aids) status * any red-blood-cell (rbc) transfusion within 28 days before randomization and/or during screening * currently receiving thalidomide or lenalidomide without prophylactic anticoagulant therapy * currently receiving or planned to receive myeloablative radiation therapy * received bone marrow or stem cell transplant in the 6 months prior to screening or planned during the study * received any erythropoietic therapy within 28 days before randomization and/or during screening (eg rhuepo or darbepoetin alfa) * known sensitivity to any erythropoietic agents, the investigational product or its excipients to be administered during this study * known sensitivity to iron administration * pregnant or breast feeding

Keywords: anemia chemotherapy induced anemia darbepoetin alfa cancer
traditional electrosurgery system versus low thermal tissue dissection system for total mastectomy

Conditions: Seroma

Summary: breast cancer is one of the most common cancer among women nowadays. there are lots of modality of treatment and one of them is mastectomy. we found out that seroma is one of the disturbing postoperative complications after mastectomy. in our study we want to compare the outcome between using the conventional electrocautery and the low thermal tissue dissection. we expected that the serum production should be lower in cases using low thermal system electrosurgery system.


Eligibility criteria:
inclusion criteria: * female aged \>18 years old * patients that fulfill the indication of mastectomy * medium-sized breast volume (breast weight \< 1500 grams) exclusion criteria: * patients who cannot complete the informed consent * patients with asa class \> 3

Keywords: mastectomy seroma
gabapentin treatment of cannabis dependence

Conditions: Cannabis Dependence

Summary: this is a study to evaluate the efficacy of the medication gabapentin in treating persons with cannabis dependence.

this is a 12-week, double blind, placebo controlled, dose ranging study to evaluate the efficacy of gabapentin in treating outpatients with cannabis dependence. counseling and research assessments occur weekly throughout the 12-week treatment phase.

Eligibility criteria:
inclusion criteria: * males or females age 18-65 with cannabis dependence * meets dsm-iv-tr criteria for cannabis dependence * smoked marijuana at least once a week in the 90 days prior to study participation * willing to attend 12 weekly study visits and 1 follow-up visit exclusion criteria: * currently meets dsm-iv-tr criteria for dependence on illicit substances other than cannabis * significant medical disorders that will increase potential risk or interfere with study participation * women with childbearing potential who are pregnant, nursing, or refuse to use a reliable method of birth control * treatment with an investigational drug in the last month

Keywords: cannabis treatment marijuana treatment
us-guided biopsy in the diagnosis of musculoskeletal soft-tissue tumors

Conditions: Soft Tissue Neoplasm; Soft Tissue Sarcoma; Soft Tissue Mass; Soft Tissue Lesion

Summary: a retrospective evaluation of soft tissue tumors that have undergone core needle biopsy with us guidance (us-cnb)

the present study is designed to be the first step in the creation of an interdisciplinary platform collecting data on patients and procedures to provide a predictive tool to help physicians in the management of patients affected by a soft tissue lesion. the primary aim of our work is to evaluate the diagnostic yield of us-cnb. the secondary aim is to exploit all the imaging data conventionally available at a sarcoma center before a biopsy on a soft tissue mass, to build a multiparametric model and score of prediction of malignancy, and eventually of biological behavior - grading.

Eligibility criteria:
inclusion criteria: * patients undergone us-cnb for soft tissue lesions at the rizzoli orthopaedic institute exclusion criteria: * patients whose histological diagnosis is not available

Keywords: us-cnb soft tissue mass soft tissue sarcoma soft tissue neoplasm soft tissue lesion
predictive factorsfor final pathologic ureteral sections

Conditions: Urothelial Carcinoma

Summary: to identify preoperative predictive factors for final ureteral section invasion after radical cystotomie (rc) and to validate significant factors on an external independent cohort. the investigators retrospectively reviewed data of all consecutive rc performed for bladder cancer in 2 high-volume institutions. clinical, pathological, and follow-up data were collected prospectively and reviewed retrospectively. pathological evaluation was performed by 2 well-trained uropathologists in each center. logistic regression analyses were performed to identify predictive factors for final ureteral sections involvement. significant factors in cohort a were validated in cohort b. receiver operating curve and area under curve were modeled to evaluate predictive accuracy of the markers

to identify preoperative predictive factors for final ureteral section invasion after radical cystotomie (rc) and to validate significant factors on an external independent cohort. pathological evaluation was performed by 2 well-trained uropathologists in each center (y.a. and c.c). the investigators retrospectively reviewed data of all consecutive rc performed for bladder cancer in 2 high-volume institutions. clinical, pathological, and follow-up data were collected prospectively and reviewed retrospectively. pathological evaluation was performed by 2 well-trained uropathologists in each center. logistic regression analyses were performed to identify predictive factors for final ureteral sections involvement. significant factors in cohort a were validated in cohort b. receiver operating curve and area under curve were modeled to evaluate predictive accuracy of the markers

Eligibility criteria:
inclusion criteria: * patients \> 18 years * patients reoperative predictive factors for final ureteral section invasion after radical cystectomy exclusion criteria: * patients \< 18 years

Keywords: radical systectomy ureteral frozen section
randomized controlled study of plasmaknife tonsillectomy versus monopolar tonsillectomy

Conditions: Obstructive Tonsillar Hypertrophy; Tonsillitis

Summary: study objective is to provide prospective randomized controlled data on pediatric pain levels found in plasmaknife tonsillectomy and monopolar tonsillectomy.

this is a prospective, randomized controlled study to compare the efficacy of the gyrus acmi plasmaknife™ electrosurgical device used with the gyrus acmi workstation versus monopolar electrosurgical device (i.e. bovie®) for tonsillectomy. the primary outcome will study the potential for reduced post-operative pain when the plasmaknife is used for tonsillectomy compared to a monopolar device. secondary outcomes such as return to normal diet and activity as well as a range of complications including primary and secondary bleeding will be included in the study. the study will involve approximately 100 patients at children's hospital of michigan that meet the criteria for tonsillectomy (with or without adenoidectomy) for infected tonsils or airway obstruction. the study will be documented through the use of case report forms.

Eligibility criteria:
inclusion criteria: * patient should be between the ages of 4 and 16 years old inclusive. * patient should meet criteria for tonsillectomy. * patient's guardian able and willing to complete patient diary and keep to the follow-up visit. * guardian able to understand english (written and oral). exclusion criteria: * patient that has active medical implant(s) such as pacemaker, cochlear implant, etc. * patient has abnormal blood coagulation, history of easy bruising, bleeding disorders or uses anti-coagulants. * morbidly obese children (calculated bmi over 39) * patient that has history of malignancy or acute peritonsillar abscess * patient has sickle cell disease or is immunocompromised. * patient is pregnant or lactating. * active infection with fever greater than 101.5 degrees f. * history of heart disease, diabetes or hypertension (with systolic blood pressure \> 160 mmhg). * craniofacial anomaly. * biopsy of tonsil needed to rule out neoplasm.

Keywords: chronic tonsillitis recurrent tonsillitis
how important are hematological parameters in the prognosis of severe covid-19 patients?

Conditions: COVID-19

Summary: it is aimed to reveal the treatment and prognostic values by evaluating the differences in hematological parameters and indices, especially in dead covid-19 cases. material method: it is planned to retrospectively examine the hemogram parameters of 125 male, 44 female and 169 critical covid-19 patients hospitalized between 01.03.2020 and 31.12.2021. subjects were divided into 2 groups as deceased (77) and living (92) patients according to demographic data such as age and gender. statistical evaluation: all analyzes were spss 25.0, kolmogorov smirnov test was used to determine distribution, median and interquartile range (tukey's hinges percentile) were used to summarize variables. the differences between the independent-samples mann whitney u test and the data of the patient groups and the optimal cut-off values, sensitivity and specificity values will be determined by roc analysis. it will be considered statistically significant when the p value is below 0.05 (with the two-tailed test)

the aim of this study is to examine the effectiveness of routine laboratory complete blood count parameters and rates as diagnostic and prognostic criteria in severe covid-19.

Eligibility criteria:
inclusion criteria: 1. patients over the age of 18 2. critical patients taken to intensive care 3. the length of stay in the icu is more than 24 hours exclusion criteria: 1) patients under 18 years of age (2) patients with hematological malignancies (3) the length of stay in the icu is less than 24 hours.

Keywords: hemogram nlr mpv/plt mpv/pct
ambispective observational multicenter study on the efficacy of the third dose of vaccine anti covid-19 in patients suffering from solid tumors undergoing oncological treatment active.

Conditions: Oncologic Complications

Summary: to evaluate the serum neutralizing antibody titre in cancer patients undergoing active treatment against variants (voc) before and after the third dose of bnt162b2 covid-19 vaccine.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 years or older, regardless of gender; 2. life expectancy (estimated by the treating doctor) ≥ 6 months; 3. histological diagnosis confirmed solid neoplasm; 4. under active treatment 5. previous two doses of pfizer anti-sars-cov-2 vaccine received (will be considered also patients who have completed the vaccination cycle with other mrna vaccines - modern-) 6. all participants subscribed and signed the informed consent form first of enlistment 7. patients with a positive history of a previous diagnosis are also enrolled laboratory confirmed covid-19 8. ecog 0-2 exclusion criteria: 1. inability to sign informed consent