Kornimate/medical-research-clean huggingface dataset:
incidence of fragility fractures and osteoporosis screening in chronic stroke patients

Conditions: Chronic Stroke; Osteoporosis; Fragility Fractures

Summary: stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. several international studies have associated stroke with hip fractures, showing an odds ratio ranging between 1.5 and 4. the literature frequently indicates a lack of management for bone metabolism in patients following cerebrovascular events. this study aims to evaluate the incidence of osteoporosis and fragility fractures in patients with chronic stroke. a secondary aim is to assess whether patients have been adequately screened for bone metabolism following a cerebrovascular event. this study is designed as a prospective observational study. patients aged over 65 years with chronic stroke are assessed at the u.o.c. of "functional recovery and rehabilitation" at a.o.u.p. "p. giaccone," palermo. during the assessment, clinical and demographic data are collected, including details of the cerebrovascular event (location, hemorrhagic/ischemic, date), pre-event and post-event disability/autonomy (rankin scale), presence of fractures (location and date) in the patient's medical history (pre and post-event), femoral and lumbar dexa for osteoporosis evaluation, and defra for assessing the 10-year risk of fragility fractures.


Eligibility criteria:
inclusion criteria: * patients aged 65 years and older * diagnosed with chronic stroke * able to provide informed consent * willing to participate in follow-up assessments * stable medical condition that allows participation in the study exclusion criteria: * patients with acute stroke * severe cognitive impairment that prevents informed consent * other major illnesses affecting bone metabolism (e.g., severe renal disease) * patients already undergoing treatment for osteoporosis * patients with conditions that contraindicate dexa scan

Keywords: chronic stroke osteoporis fragility fractures hip fractures stroke risk factors bone density (dexa) bone bone mineral density bone metabolism bone health bone health intervention post-stroke bone density screening
survey of sensory and motor tricks in focal dystonia

Conditions: Focal Dystonia

Summary: this study will collect information on (tricks) patients with focal dystonia use to relieve their symptoms. dystonia is a movement disorder caused by sustained muscle contractions often causing twisting and abnormal posturing. dystonia may be generalized, affecting at least one leg and the trunk of the body, segmental, affecting adjacent body parts, or focal, affecting a single body part, such as the hand or eyelid. it may be task-specific, such as writer's, musician's or sportsman's cramps. some patients with focal dystonia use (tricks), such as touching the face or hand, to stop or alleviate the abnormal movement. this study will survey the types of tricks people with focal dystonia use in order to learn more about the disorder. patients 18 years of age and older with focal dystonia may be eligible for this study. candidates will be screened for eligibility with a medical history, clinical evaluation, and review of their medical records. in one 30- to 45-minute clinic visit, participants will be interviewed about their dystonia symptoms and the tricks they use to relieve the symptoms. they may be asked to show the investigators how the tricks work

the purpose of this study is to collect and organize information concerning a phenomenon known as 'sensory tricks' or geste antagoniste in focal dystonia. sensory tricks, which we will refer to as 'tricks' since some involve motor as well as sensory input, are various stimuli used by dystonic patients to transiently diminish their spasms (jankovic and fahn 1993). the phenomenon of tricks is evidence for the abnormality of sensorimotor integration in focal dystonia, yet it is little studied or understood. a survey of the history and characteristics of tricks will lead to a better understanding of this puzzling phenomenon, and a step toward the understanding of the mechanism of focal dystonia.

Eligibility criteria:
inclusion criteria patients with focal dystonia diagnosed by review of medical record, history, and clinical evaluation. exclusion criteria any individual without focal dystonia. any individual who is unable to provide accurate history, or is critically ill.

Keywords: geste antagoniste tms sensorimotor integration writer's cramp sensory input focal dystonia
a modified approach for morbid obese with gynecologic cancer

Conditions: Malignant Neoplasm of Cervix, Endometrium and Ovary

Summary: comparing standard midline approach with the modified approach in management of morbid obese patients with gynecologic cancers.


Eligibility criteria:
inclusion criteria: 1. resectable (ovarian, endometrial, cervical) cancers. 2. anaesthetically fit (asa 1 and 2). 3. abdominal pannus below symphysis pubis. exclusion criteria: 1. non resectable gynecologic cancer. 2. unfit patients. 3. patients who refuse to share in the trial.

Keywords: gynecologic cancer - panniculectomy
muscle mass or muscle function as a prédictive tools for outtcomme in chronic dialysis patients

Conditions: Chrnoic Haemodialysis Patients

Summary: aim of this study is to compare the association of muscle mass and functionality with mortality among chronic haemodialysis * the involvement of malnutrition inflammation and atherogenesis syndrome (increase in c reactive protein and decrease in serum albumin) on voluntary muscle strength impairment and phyiscal activity. * the relationship between voluntary muscle strength and mortality * the relationship between voluntary muscle strength and physical activity

aim of this study is to compare the association of muscle mass and functionality with mortality among chronic haemodialysis * the involvement of malnutrition inflammation and atherogenesis syndrome (increase in c reactive protein and decrease in serum albumin) on voluntary muscle strength impairment and phyiscal activity. * the relationship between voluntary muscle strength and mortality * the relationship between voluntary muscle strength and physical activity

Eligibility criteria:
inclusion criteria: * chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months * stable clinical condition (absence of infection, stroke or acute decompensation) exclusion criteria: * chronic kidney disease without extrarenal replacement therapy * history of renal transplantation

Keywords: chronic kidney disease muscle strength muscle mass lean body mass physical activity
respiratory muscle training in stroke swallowing disorders

Conditions: Swallowing Disorder; Stroke; Respiratory Muscle Training; Malnutrition

Summary: clinical randomized clinical trial to assess the effectiveness of incorporating inspiratory and expiratory muscle training (iemt) in the rehabilitation of stroke patients with dysphagia in terms of functional outcomes, comorbidities, survival and quality of life. this project also incorporates a longitudinal study to assess the clinical impact of dysphagia on body composition and nutritional status in stroke patients.

stroke is a major cause of morbidity and mortality worldwide. stroke can lead to varying degrees of oropharyngeal dysphagia (25-85% of patients) and respiratory muscle dysfunction associated with an increase in medical complications such as bronchoaspiration, malnutrition and death. dysphagia is present in a significant proportion of patients admitted to rehabilitation (up to 85% depending on series) in stroke. standard swallow therapy consists of educational intervention aimed to improve self-management of dysphagia and protect the airway, oral exercises to improve lingual praxis, and compensatory techniques based on videofluoroscopic findings. recent studies suggest that iemt can improve swallowing efficacy and reduce eventual bronchoaspiration events. nutritional status appears in 9-67% of patients with acute and subacute stroke and has an impact on functional outcomes and provides information about the risk of hospitalization and death. stroke patients are at risk of developing malnutrition because of neurologic impairments related to feeding (chewing, deglutition and self-feeding) that can result in a poor food intake. to date, there is only few studies on prevalence and influence of malnutrition in stroke.

Eligibility criteria:
inclusion criteria: * first-ever ischemic or haemorrhagic stroke * time since stroke onset: 1 month * dysphagia confirmed by videofluoroscopic study with a score \>3 in the 8-point penetration aspiration scale. * mini-mental state exploration \> 24) exclusion criteria: * aphasia * history of cardiopulmonary disease; neurologic condition other than stroke and metabolic disease * medical treatment with potential effect on muscle structure and function
a rct on supraglottic airway versus endotracheal intubation in ohca

Conditions: Prehospital Airway Management in Patients With Cardiac Arrest

Summary: in this 3-year successive research plan, investigators will conduct a prehospital randomized controlled trial to address the following question: in adult patients with non-traumatic cause of out-of-hospital cardiac arrest resuscitated by emergency medical technician (paramedic level) in the prehospital setting, will receiving endotracheal tube intubation cause a better chance of sustained recovery of spontaneous circulation and other survival outcomes like neurologically favorable status, comparing to those who receiving supraglottic airway device.


Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest; ohca * age ≥ 20 years old * non-traumatic cause exclusion criteria: * signs of obvious death, eg. decapitation or rigor mortis * theoretically not suitable for eti, eg. facial deformity or third-trimester pregnancy * theoretically not suitable for sga, eg. foreign-body airway obstruction * with "do not attempt resuscitation" order * the occurrence of ohca during ambulance transport * rosc in the field with clear consciousness and spontaneous adequate ventilation * advanced airway being established before the arrival of paramedics

Keywords: out-of-hospital cardiac arrest (ohca) supraglottic airway (sga) endotracheal intubation (eti) emergency medical system (ems) supraglottic airway versus endotracheal tube (save)
evaluation of the media detective program for elementary school-aged children to prevention substance use

Conditions: Alcohol Drinking; Tobacco Smoking

Summary: the purpose of this study was to determine whether a media literacy education program taught be teacher to late elementary school students (grades 3-5) positively affected students' critical thinking skills and substance use-related health outcomes.

media detective is a 10-lesson elementary school, substance abuse prevention program developed based upon the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. the purpose of this study was to conduct a short-term randomized controlled trial study to evaluate the effectiveness of media detective for achieving these goals.

Eligibility criteria:
inclusion criteria: * must be able to read and write in english exclusion criteria: * none
a comparative efficacy study of dermapure™ to treat diabetic foot ulcers

Conditions: Diabetic Foot Ulcers

Summary: this study has been designed to help determine how safe and effective dermapure™ may be in treating hard-to-heal diabetic foot ulcers compared to the current standard of care.

dermapure™ is a decellularized dermal skin substitute using the tissue regenix dcell® patented technology to remove cells and other components from human and animal tissue while maintaining the native structural and biomechanical properties. the primary objective of the study is to establish the wound healing performance and safety of dermapure™ over a 12 week period, when administered to "hard to heal" chronic, neuropathic diabetic foot ulcers. this study has been designed to compare the performance of dermapure™ (in combination with standard care) versus standard care alone.

Eligibility criteria:
inclusion criteria: * type 1 or type 2 diabetes with hba1c ≤12% * adequate perfusion * a full thickness chronic, neuropathic diabetic foot plantar ulcer defined by texas or wagner classification. * target ulcer decreases in size (surface area) by less than 30% in the 2 week screening period. exclusion criteria: * bmi greater than 45kg/m2. * presence of infection * presence of necrosis, purulence or sinus tracts that cannot be removed by aggressive debridement. * a clinical diagnosis of an active/acute charcot neuroarthropathy. inactive/chronic charcot does not exclude the patient. * therapy with any investigational agent or drug within 4 weeks preceding the screening visit. * more than 2 weeks treatment with immunosuppressive agents within 3 months of enrollment. * evidence of malnutrition as confirmed by serum pre-albumin level at screening. * evidence of drug or alcohol abuse,

Keywords: dermis diabetic foot ulcers skin substitutes decellularized
cognitive intervention with go and chess in early and subjective cognitive decline

Conditions: Mild Cognitive Impairment; Subjective Cognitive Decline

Summary: the goal of this clinical trial\]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline. the main questions it aims to answer are: * do go and chess improve cognition? * is a game better than the other? is the effect of both games on cognition synergistic? * do go and chess improve quality of life? * do go and chess improve mood? * do go and chess improve lifestyle? participants will be randomized to one of four groups: * group intervention with go, once a week, for 12 weeks * group intervention with chess, once a week, for 12 weeks * group intervention with go and chess, twice a week, for 12 weeks * control group


Eligibility criteria:
inclusion criteria: * diagnosis of mild cognitive impairment or subjective cognitive decline * willingness to participate in the board games classes * living within 20-minute driving distance from the center * signed informed consent exclusion criteria: * prior knowledge of the the game rules (in case the subject knows one of the two, they can be randomized to the other one) * significant linguistic or sensory impairment (according to clinical judgment) * significant behavioral or psychiatric disturbances (according to clinical judgment) * significant medical comorbidities (according to clinical judgment)

Keywords: subjective cognitive decline mild cognitive impairment cognitive enhancement board games
nitrous oxide for pain management during iud insertion in nulliparous adolescent women

Conditions: Contraceptive Devices; Long-Acting Reversible Contraception; Analgesia; Adolescent Health; Gynecology

Summary: this pilot study aims to assess the feasibility, acceptability, and effectiveness of using nitrous oxide (n2o) sedation for intrauterine device (iud) insertions for nulliparous adolescent and young adult women in a primary care clinic setting.

the objective of this research study is to learn more about how to make the intrauterine device (iud) insertion procedure more comfortable. iuds are highly effective at preventing pregnancy and are also used to treat gynecological conditions such as endometriosis or heavy periods. unfortunately, many adolescents and young adults do not get an iud because the insertion procedure can be painful. currently, there are no medications that successfully reduce pain during iud insertion for adolescents in the outpatient clinic setting. we plan to study if nitrous oxide sedation is a feasible strategy for improving the iud insertion experience for adolescents and young adult women. although nitrous oxide is already used to manage pain and anxiety in other medical settings (such as for pain during labor or dental procedures), nitrous oxide sedation has not been rigorously studied for iud insertions in teenagers and young adults. during phase one of our study ("pre-implementation phase"), study participants will receive current standard of care (ibuprofen) for managing pain during iud insertions. in phase two ("post-implementation phase"), study participants will receive nitrous oxide sedation in addition to ibuprofen during iud insertions. we will survey study participants to assess the feasibility, acceptability, and effectiveness of nitrous oxide sedation for iud insertions in the primary care clinic setting. this study will help clinicians understand whether nitrous oxide could be a practical and effective way to manage pain and anxiety for adolescents during iud insertion procedures. ultimately, we hope this study will lead to increased satisfaction with the iud insertion procedure and increased use of this highly effective method of contraception among adolescents.

Eligibility criteria:
inclusion criteria: * nulliparous (no pregnancy of 24 weeks' duration or longer and not currently pregnant) * adolescent females (14-24 years) exclusion criteria: * use of opioids, benzodiazepines, or marijuana within the past 24 hours * failure to meet medical eligibility criteria for an iud * medical contraindications to nsaid use * relative contraindications to n2o administration, including severe pulmonary disease, congenital heart disease, diseases associated with vitamin b12 deficiency, and sickle cell disease
lurasidone - a 6-week study of patients with bipolar i depression (add-on)

Conditions: Bipolar Depression

Summary: this clinical study is designed to test the hypothesis that lurasidone is effective, tolerable, and safe when added to treatment with lithium or divalproex for the treatment of patients with bipolar i depression.


Eligibility criteria:
inclusion criteria: * subject is diagnosed with bipolar i disorder, most resent episode depressed * subject must have a lifetime history of at least one bipolar manic or mixed episode * subject must be taking lithium or divalproex at least 28 days prior to screening exclusion criteria: * history of nonresponse to an adequate (6-week) trial of three or more antidepressants (with or without mood stabilizers) during the current episode * subject has been hospitalized for a manic or mixed episode within 60 days prior to randomization * imminent risk of suicide or injury to self, others, or property

Keywords: bipolar i latuda lurasidone
crc detection reliable assessment with blood

Conditions: Colorectal Cancer; Adenomas Colon; Colon Cancer; Rectal Cancer; Colon Neoplasm; Colon Lesion; Colon Disease; Colon Polyp; Polyps; Adenoma; Rectal Diseases; Rectal Polyp; Gastrointestinal Neoplasms; Intestinal Neoplasms; Colonic Diseases, Functional; Intestinal Disease

Summary: the crc draw study will assess the sensitivity and specificity of the blood-based, next-gen crc screening test for the detection of crc.

the crc draw study is a prospective, multi-center, observational study to validate the next-gen crc screening test for the detection of crc. the study will collect blood samples from average-risk participants scheduled for screening colonoscopies.

Eligibility criteria:
inclusion criteria: 1. participant is 45 years of age or older at time of enrollment. 2. participant is at average risk for development of colorectal cancer (as defined by inclusion and exclusion criteria) 3. participant is able and willing to undergo a screening colonoscopy 4. participant is able and willing to sign informed consent and adhere to study requirements 5. participant is able to provide blood sample prior to colonoscopy (within 90 days of scheduled colonoscopy). exclusion criteria: 1. previous personal history of crc or precancerous lesions 2. positive result from non-invasive screening test within the associated recommended intervals: 2.1 fecal occult blood test or fecal immunochemical test within the previous 12 months 2.2 epi procolon test within the previous 12 months 2.3 fit-dna (cologuard) test within the previous 36 months 3. diagnosed with condition associated with higher risk for colorectal cancer, such as: 3.1 inflammatory bowel disease (ibd) 3.2 chronic ulcerative colitis (cuc) 3.3 crohn's disease 3.4 familial adenomatous polyposis (fap) 3.5 familial history for colorectal cancer 3.5.1 one or more first-degree relatives diagnosed with crc or adenomatous polyps before 60 years of age 3.5.2 two or more first degree relatives diagnosed at any age with crc 4. individuals with relevant familial (hereditary) cancer syndrome, such as: 4.1 hereditary non-polyposis colorectal cancer syndrome (hnpcc or lynch syndrome) 4.2 peutz-jeghers syndrome 4.3 myh-associated polyposis (map) 4.4 gardner's syndrome 4.5turcot's (or crail's) syndrome 4.6 cowden's syndrome, 4.7juvenile polyposis 4.8 cronkhite-canada syndrome 4.9 neurofibromatosis 4.10 familial hyperplastic polyposis 5. diagnosed with chronic gastritis or cirrhosis 6. current diagnosis of any cancer, except non-melanoma skin cancer 7. overt rectal bleeding or bleeding hemorrhoids within previous 30 days 8. a colonoscopy within the previous 9 years, with the exception of a failed colonoscopy due to poor bowel preparation 9. pregnancy
the effects of immersion in dead sea water on glucose levels in type 2 diabetes mellitus patients

Conditions: Type 2 Diabetes Mellitus

Summary: background: bathing in sweet or mineral water can induce significant physiological changes in several body systems including the endocrine system. to date, there have only been a small number of reports that balneology can reduce blood sugar levels in patients with type 2 diabetes mellitus (dm\]. objective: to compare the effects of a immersion in sweet or mineral water on blood glucose levels in patients with type 2 dm. methods: forty patients with type 2 dm will immerse in either sweet or mineral water twice daily. in both cases the water will be warmed to a temperature of 35 degrees c and the bath continue for 20 minutes.


Eligibility criteria:
inclusion criteria: * uncontrolled type 2 diabetes mellitus patients(hba1c levels between 7.5-10) * ages 18-65 * signed informed consent exclusion criteria: * peripheral neuropathy * diabetic ulcers or damaged skin * pvd * diabetes diagnosis for over 20 years * orthostatic hypotension