Kornimate/medical-research-clean huggingface dataset:
the acute effect of coffee consumption on stomach, self-reported gastrointestinal symptoms and stress.

Conditions: Stress; Signs and Symptoms, Digestive; Blood Pressure; Increased Secretion of Gastrin

Summary: this study investigated the acute effect of the consumption of four different kinds of coffee (hot and cold instant coffee, cold espresso and hot filter coffee) with the same caffeine content on salivary gastrin, cortisol and alpha-amylase concentrations, on self-reported gastrointestinal symptoms and on psychometric assessments in healthy individuals.

coffee consumption is very common in greece. many of the consumers support that certain types of coffee and especially instant coffee cause gastrointestinal symptoms in healthy individuals. up to now, few studies have investigated the relationship between coffee consumption, gastrointestinal symptoms and stress in healthy individuals with conflicting results.coffee consumption is related with increased gastric acid and gastrin secretion, however it does not seem to affect stomach or stomach walls. stress, which characterizes modern lifestyle, also is found to increase gastric acid and gastrin secretion and seems to be exclusively responsible for gastrointestinal symptoms.

Eligibility criteria:
inclusion criteria: * stable body weight for at least 1 month prior to study enrollment. exclusion criteria: * if one volunteer consumed breakfast more than three days a week, their daily caffeine intake was over 500 mg caffeine, was taking medication, their psychological state was strongly influenced by some exogenous factor (e.g. moving to a new house, new job, divorce e.t.c.), was on hypocaloric diet for weight loss, was smoking more than five cigarettes a day, was an athlete with very vigorous physical activity (\> 4 hours vigorous exercise a day), had a history of gastrointestinal disorders (e.g. gastroesophageal reflux disease (gerd), irritable bowel syndrome, diarrhea, ulcers e.t.c.), depression, diabetes, kidney disease, hypertension, blood disorders, liver disease, unregulated hyper - or hypothyroidism, arrhythmia, heart disease, cancer, vascular disease, recent surgery, or severe psychiatric disorders was automatically excluded from the study.

Keywords: coffee gastrin alpha-amylase cortisol self-reported gastrointestinal symptoms self-reported stress blood pressure
increased risk of adhd among children with bilateral congenital cataracts

Conditions: Childhood Cataract

Summary: in this study, the investigators conducted a cross-sectional, face-to-face investigation to evaluate the behavioral and psychological disorders and the risk of adhd among children with bilateral congenital cataracts using the conners'parent rating scale (cprs) questionnaire, an assessment tool for screening adhd that obtains parental reports of childhood behavioral problems in research and clinical settings.15-17 age-matched children with normal vision and the chinese urban norm were used as controls.


Eligibility criteria:
inclusion criteria: * cc children and nv children aged 3-8 years presenting to the zhognshan ophthalmic center between july and december 2016. exclusion criteria: * patients complicated with systemic manifestations, such as lowe syndrome, marfan syndrome, and down syndrome, were excluded.

Keywords: congenital cataract attention deficit hyperactivity disorder conners'parent rating scale-48
prediction of hypotension during induction of general anesthesia

Conditions: Anesthesia

Summary: post induction hypotension is closely related to postoperative complications. patients are at high risk of hypotension due to preexisting hypovolemia and the vasodilatory effects of induction agents. ultrasonographic measurement of the carotid artery corrected flow time and internal jugular vein collapsibility index may predict post induction hypotension.

* type of study: observational prospective cohort design. * study setting and ethical consideration: the approval of the scientific research ethics committee of the faculty of medicine, ain shams university will be obtained before starting work on the study. this study will be conducted in operating theatres of ain shams university hospitals. informed written consents to participate will be obtained from the patients. * study period: one year (october 2023-october 2024) * study population: adult patient undergoing elective surgeries.

Eligibility criteria:
inclusion criteria: * 1- patients of american society of anesthesiologists (asa) physical status i to ii of both genders. 2- aged 18-65 years. 3- elective surgeries under general anesthesia. 4- bmi less than 40. exclusion criteria: * patients with 1. renal diseases. 2. hepatic diseases. 3. asa scores of 3-4. 4. the presence of a left ventricular ejection fraction less than 50%. 5. age under 18 years old. 6. patient refusal. 7. coronary heart disease. 8. cardiac disease including cardiomyopathy and mild to severe valve disease. 9. pulmonary hypertension. 10. peripheral arterial disease. 11. preoperative cervical vascular ultrasound abnormalities including plaque, stenosis and anatomical variation. 12. any previous neck surgery or trauma.
evaluation of the safety and effectiveness of aceclidine/brimonidine (lnz101) and aceclidine (lnz100) in the treatment of presbyopia

Conditions: Presbyopia; Refractive Errors; Eye Diseases

Summary: to evaluate the safety and effectiveness of aceclidine/brimonidine (lnz101) compared with aceclidine (lnz100) and vehicle in the treatment of presbyopia.


Eligibility criteria:
inclusion criteria: subjects must: 1. be able and willing to provide written informed consent and sign health information portability and accountability act (hipaa) form prior to any study procedure being performed; 2. be able and willing to follow all instructions and attend study visits; 3. be 45-75 years of age of either sex and any race or ethnicity at visit 1; 4. have +1.00 to -4.00 diopter (d) of sphere (so that se results in myopia no more severe than -4.00 se. see inclusion 5 below) in both eyes determined by manifest refraction documented at visit 1; 5. have up to 2.00d of cylinder (minus cylinder) in both eyes determined by manifest refraction documented at visit 1; 6. be presbyopic as determined at visit 1 exclusion criteria: subjects must not: 1. be a female of childbearing potential who is currently pregnant, nursing or planning a pregnancy; 2. have known contraindications or sensitivity to the use of any of the study medications(s) or their components; 3. have an active ocular infection at visit 1 (bacterial, viral or fungal), positive history of an ocular herpetic infection, preauricular lymphadenopathy, or ongoing, active ocular inflammation (e.g., moderate to severe blepharitis, allergic conjunctivitis, peripheral ulcerative keratitis, scleritis, uveitis) in either eye; 4. have moderate or severe dry eye determined by total corneal fluorescein staining at visit 1; 5. have clinically significant abnormal lens findings (e.g., cataract) including early lens changes and/or any evidence of a media opacity in either eye during dilated slit-lamp biomicroscopy and fundus exam documented within 3 months of visit 1;

Keywords: pharmaceutical solutions miotics ophthalmic solutions near vision eye drops insight 1
evaluation of ocular surface inflammatory mediators effected by lotemax

Conditions: Sjogren's Disease

Summary: the purpose of this study is to evaluate the effects of an anti-inflammatory drug (lotemax®) on the surface of the eye and tear film (a film that coats the eye which is made up of oil and water).


Eligibility criteria:
inclusion criteria: * age 50-70 * diagnosed with sjogren's disease * good general health (defined by medication use that has not changed within the last 2 months and the absence of medical conditions that are deemed confounding to the data as determined by the pi) * ability to give informed consent * willing to spend time for the study; approximately one hour for a screening visit and between 60-90 minutes for each of the measurement visits * either gender * any racial or ethnic origin exclusion criteria: * use of any prescription ocular medication (such as but not limited to, glaucoma medications and restasis) used within 14 days of the screening visit or started prior to the measurement visit(s). * current acute eye disease that affects the surface of the eye such as, but not limited to blepharitis, ocular allergy, and infection. * subjects who have had cataract surgery less than one year ago * use of soft or hard contact lenses. * female subjects may not be pregnant or lactating (subjects will be asked to self-report these conditions). * inability to provide analyzable data

Keywords: non-invasive instruments environment wavefront placido disk ellipsometer thermal imaging
role of surgery in advanced ovarian cancer

Conditions: Ovarian Cancer

Summary: to demonstrate that ultra-radical surgery with multiple visceral resections and high tumor burden prior to surgery independently reduces the survival of patients with advanced ovarian cancer treated with complete cytoreductive surgery.

primary objective : to demonstrate that ultra-radical surgery with multiple visceral resections and high tumor burden prior to surgery independently reduces the survival of patients with advanced ovarian cancer treated with complete cytoreductive surgery. secondary objectives: 1. demonstrate that, in patients with advanced ovarian cancer (figo stage iiic-ivb) treated by complete cytoreduction surgery, the high tumor load before surgery decreases survival. / evaluate whether there is a sub-group of patients at risk for whom the high tumor burden prior to surgery reduces survival. 2. demonstrate that, in patients with advanced ovarian cancer (figo stage iiic-ivb) treated by complete cytoreduction surgery, the extension of carcinomatosis to the upper abdomen reduces the chances of survival. / assess whether there is a subgroup of patients at risk for whom the extension of carcinomatosis to the upper abdomen reduces survival. 3. demonstrate that, in patients with advanced ovarian cancer (figo stage iiic-ivb) treated by complete cytoreduction surgery, invasion of the celiac lymph nodes reduces survival rates. / assess whether there is a subset of patients at risk where the invasion of the celiac lymph nodes reduces survival. 4. demonstrate that, in patients with advanced ovarian cancer (figo stage iiic-ivb) treated with complete cytoreduction surgery, combination with surgical procedures reduces survival. / evaluate whether there is a sub-group of at-risk patients for whom the combination of surgical procedures with ultra-radical surgery reduces survival.

Eligibility criteria:
inclusion criteria: * confirmed histological diagnosis of ovarian epithelial cancer * complete cytoreduction surgery exclusion criteria: * women under 18 years or presence of residual tumor \>2.5mm after surgery or lack of data on performed surgical procedures or surgery performed before 2008, january or after 2015, decembrer.

Keywords: surgery cancer ovarian advanced
phase iii clinical study to evaluate the efficacy and safety of the combination of lercanidipine/valsartan in hypertensive patients

Conditions: Hypertension

Summary: this study aims to compare and assess the efficacy and the safety of the combination agent of lercanidipine and valsartan and monotherapy of lercanidipine alone in patients with essential hypertension


Eligibility criteria:
inclusion criteria: * patients aged ≥ 20 to ≤75 years old * patient with essential hypertension exclusion criteria: * when the bp level measured at screening was sitdbp\>120 mmhg or sitsbp \>180 mmhg * patient with difference in repeatedly measured blood pressures from the selected arm at screening was sitsbp≥ 20mmhg or sitdbp ≥ 10mmhg
post pandemic pneumococcal carriage among children and adults

Conditions: Pneumococcal Carriage

Summary: the pi propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city. these data will allow pi to assess the post-pandemic population structure, investigate the phylogenetic relationship between isolates from children and adults, and compare pneumococcal populations across diverse geographic areas.

the sars-cov-2 pandemic profoundly impacted human health directly and indirectly. as such, elucidating pre- and post-pandemic trends in the epidemiology and population genomics of human respiratory pathogens including those such as the bacteria streptococcus pneumoniae, a human commensal and the causative agent of invasive pneumococcal disease (ipd), merits study. nasopharyngeal samples will be processed at the pis laboratory to identify s. pneumoniae. if present, the isolate will undergo bacterial whole genome sequencings and population dynamic analysis. carriage prevalence and serotype composition will be compared to extant studies and pneumococcal genomic data will be analyzed in the context of samples from the us and abroad.

Eligibility criteria:
inclusion criteria: * children, ages 7 to 59 months (less than 5 years) * adults, ages 50 and older * ability to provide informed consent (from parents for children participants) * ability to read and speak in english * agree to comply with study procedures (complete online data questionnaire and provide a nasopharyngeal collection). exclusion criteria: * have been on an antibiotic in the last 2 weeks * have a respiratory infection that would make an nasopharyngeal collection improbable * have underlying developmental or chronic conditions impacting immune or respiratory function (e.g., immunocompromised, cystic fibrosis, cerebral palsy, paralysis) * adults unable to consent, individuals who are not yet adults, and prisoners will be excluded from this study.

Keywords: nasopharyngeal children pandemic genomic epidemiology pneumococcal carriage streptococcus pneumoniae
dietary intake and nutrient status of children with adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: assess the dietary intake of children aged 6-12 years by means of a 24-hour recall and 3-day food record and asses the nutrient status of vitamin b6, serum ferritin, serum zinc and serum copper of the same children by means of standard laboratory assessments.

* to document the use of vitamin and vitamin-mineral supplements * to determine the percent consumption of low nutrient density (lnd) foods * to compare the dietary intake of adhd children with the established standards of the dietary reference intakes (dris) * to compare the dietary intake of children with adhd to the dietary recommendations of canada's food guide for healthy eating * to determine whether dietary intake is moderated by drug treatment * to assess the pyridoxal-5'-phosphate (plp), serum ferritin, serum zinc, and serum copper status of adhd by standard laboratory blood test * to measure height and weight in adhd children

Eligibility criteria:
inclusion criteria: * primary diagnosis of adhd * age 6-12 years inclusive exclusion criteria: * no use of medication that affects dietary intake (eg. risperdal)

Keywords: observational dietary intake nutrient status serum assessors attention-deficit/hyperactivity disorder (adhd)
comparison of thoracoscopic talc pleurodesis by thoracic epidural or general anesthesia

Conditions: Pleural Effusion

Summary: video-assisted thoracoscopic surgery (vats) talc pleurodesis is often carried out in patients with malignant recurrent pleural effusion to relieve symptoms and prevent recurrence. general anesthesia and one lung ventilation is the standard type of anesthesia employed for vats although recently, thoracic epidural anesthesia (tea) in awake spontaneously ventilating patients is being increasingly employed to perform several cardio-thoracic surgery procedures in an attempt of minimize operative risks and facilitate resumption of daily-life activity. the investigators have reasoned that for a simple and palliative procedure such as talc pleurodesis in cancer patients is, use of general anesthesia and one-lung ventilation might be considered a potential cause of morbidity and delayed recovery. the investigators have also hypothesized tea could be considered an optimal type of anesthesia in this setting leading to a fast recovery a reduced overall workload in medical care. in this single-center randomized study, the investigators have comparatively assessed the impact of awake tea versus general anesthesia and one-lung ventilation on comprehensive results of vats talc pleurodesis.


Eligibility criteria:
inclusion criteria: * recurrent pleural effusion at the computed tomography occupying at least 1/3 of the hemithorax in patients with recent history of malignancy. * karnofsky performance status ≥ 50 * asa score ii-iii * acceptance of the randomly assigned anesthesia protocol * radiologic evidence of lung re-expansion after previous drainage/thoracentesis * absence of blood clotting disorders (inr \< 1.5) * no contraindications to tea * no neurological or psychiatric disturbance contraindicating awake surgery exclusion criteria: * patients refusal of random assignment to treatment arm * patients refusal or noncompliance to tea * patients refusal or noncompliance to general anesthesia and one-lung ventilation * unfavourable anatomy for tea * previous surgery of the thoracic spine * coagulation disorders (thromboplastin time \ 40 sec, platelet count \< 200/nl or bleeding disorders

Keywords: vats awake thoracic surgery pleurodesis talc tea epidural anesthesia video-assisted anesthesia epidural
lactobacillus reuteri progastria in helicobacter pylori-infected adult subjects on proton pump inhibitors

Conditions: Helicobacter Pylori Infection

Summary: the purpose of the study is to confirm that simultaneous use of l. reuteri progastria and omeprazole for 28 days can eradicate h. pylori in humans in the absence of antibiotics.

helicobacter pylori colonises an estimated 50% of the world´s population. despite clear clinical guidelines on the treatment of this infection there is a drive to find alternative ways to control this infection in a wider perspective without the complications of induction of antibiotic resistance in the pathogen. a good alternative is to use probiotics. lactic acid bacteria and in particular lactobacilli have been studied for their effects in humans infected with h. pylori with some success in reducing the infection load. studies using supplementation with l. reuteri in both symptomatic and non-symptomatic h. pylori-infected subjects show a clear reduction of infection load after 4 weeks of use and this was concomitant with a reduction in symptoms associated with the infection. further, dietary supplementation with l. reuteri during and after the period of h. pylori eradication therapy has also been shown to reduce the side effects of this therapy without affecting the degree of eradication.

Eligibility criteria:
inclusion criteria: * infection with h. pylori defined using the 13c-urea breath test * non-ulcer dyspepsia * no earlier eradication therapy for h. pylori infection * written informed consent * stated availability throughout the entire study period * mental ability to understand and willingness to fulfil all the details of the protocol. exclusion criteria: * duodenal or gastric ulcer * malt lymphoma * gastric resection (at any time) * first level relatives of gastric cancer patients * absence of gi symptoms * use of nsaids, aspirin or other anti-inflammatory drugs within 1 week (for occasional use) or 3 weeks (for chronic use) of inclusion * use of oral antibiotics and/or ppis and/or h2-antagonists during the 2 weeks prior to ingestion of the study product * pregnancy * participation in other clinical trials

Keywords: helicobacter pylori progastria lactobacillus reuteri omeprazole triple therapy probiotic
drug drug interaction study between bi 201335 and bi 207127 in chronic hepatitis c infected patients

Conditions: Hepatitis C, Chronic

Summary: to evaluate the drug-drug interactions between bi 201335 and bi 207127 as well as their combined effect on cyp probe drug substrates and on tenofovir and raltegravir in treatment naive or prior treatment relapse patients with chronic hepatitis c infection.


Eligibility criteria:
inclusion criteria: 1. chronic hepatitis c genotype 1 infection, diagnosed at least 6 months prior to screening 2. treatment naive or confirmed prior treatment relapse or partial response following treatment with interferon and ribavirin 3. age 18 to 70 years 4. hcv rna (hepatitis c virus ribonucleic acid) = 1,000 iu/ml at screening 5. liver biopsy or fibroscan to exclude cirrhosis exclusion criteria: 1. hepatitis c virus (hcv) infection of mixed genotype; hepatitis b virus (hbv) or human immunodeficiency virus (hiv) co-infection 2. evidence of acute or chronic liver disease due to causes other than chronic hcv infection, 3. decompensated liver disease, or history of decompensated liver disease, 4. body weight \ 125 kg, 5. clinical evidence of significant or unstable cardiovascular disease, chronic pulmonary disease, history or evidence of retinopathy or clinically significant ophthalmological disorder 6. pre-existing psychiatric condition that could interfere with the subject's participation in and completion of the study 7. laboratory parameters disorders (thalassemia major, sickle cell anemia or glucose 6 phosphate dehydrogenase deficit) 8. hemoglobin \< 12 g/dl for women and \< 13 g/dl for men 9. patients who have been previously treated with at least one dose of any antiviral or immunomodulatory drug other than interferon alfa or ribavirin for acute or chronic hcv infection
evaluation of post-operative pain during retreatment in different visits

Conditions: Post Operative Pain

Summary: endodontic retreatment is performed to alleviate symptoms of recurring infection, post-treatment disease after primary endodontic therapy. retreatment can be performed in either single or multiple visits. and have their own implications. it is important to compare the patient response and post-op pain after single vs multi-visit reendo treatment.

introduction: treating endodontic failure cases has always been a challenge for the clinician due to the complex nature of disease which includes resistant microorganisms, iatrogenic errors and cleaning and shaping of un-instrumented areas. endodontic retreatment can be done in either single or multiple visits. multiple visits have the added advantage of placement of intracanal medicament resulting in decreased bacterial load and reduced pain, whereas single visit endodontic retreatment reduces chances of inter appointment microbial contamination. this study aims to evaluate post operative pain among both groups. objective: to evaluate frequency of post-operative pain in endodontic retreatment cases after single vs multiple (two) visits root canal therapy. materials and methods: study setting: department of operative dentistry, afid rawalpindi.

Eligibility criteria:
inclusion criteria: * patients with unremarkable/ noncontributory medical history * age range between 15-45 years * cases of failed endodontic treatment resulting from inadequate root filling * no systemic disease * no periodontal disease exclusion criteria: * patients having teeth with periodontal pathology * root fractures * immature root apices * endodontic posts * root perforations * immunocompromised health were excluded from the study.