Kornimate/medical-research-clean huggingface dataset:
single and multiple-visit endodontic retreatment outcome.

Conditions: Apical Periodontitis

Summary: this study will compare the outcome of single visit retreatment and multi-visit retreatment in cases of failed root canal treated teeth.

retreatment is defined as a procedure to remove root canal filling materials from the tooth, followed by cleaning, shaping and obturating the canals.although initial root canal therapy has been shown to be a predictable procedure with a high degree of success, failures can occur after treatment. recent publications have reported failure rates of 14%-16% for initial root canal treatment. in order to prevent tooth loss in such cases, nonsurgical retreatment or apical surgery is often indicated. in this study subjects will be assigned to either the single-visit and multi-visit nonsurgical endodontic retreatment. the allocation will be performed once the chemomechanical preparation is completed. clinical and radiographic success rate will be considered as primary outcome. follow up will be carried out every 3 months, till 12-month period. pain intensity will be considered as secondary outcome.

Eligibility criteria:
inclusion criteria: * patient willingness to participate in the study. * previously root filled permanent teeth with post-treatment apical periodontitis requiring nonsurgical root canal retreatment. * failure of previous root canal treatment will be determined based on clinical and radiographic findings. clinical indicators of failure will include pain, tenderness to palpation/percussion, swelling, sinus tract.radiographic criteria will include persistent periapical radiolucent lesions in teeth in which initial treatments were performed at least 4 years previously. * root canal fillings no more than 4mm short of the apex. * patients showing no significant systemic disease exclusion criteria: * patients who are pregnant, diabetic, immunocompromised, serious medical illness or requiring antibiotic premedication. * patient under 18 years of age. * patient under corticosteroid use. * patients with history of antibiotic use in last 3 months or analgesic use in last one week will also be excluded. * multiple teeth that require treatment to eliminate the possibility of pain referral.patients with unrestorable carious lesions, fractures involving the periodontium, and/or periodontal pockets ≥ 4mm deep or having marginal or furcal bone loss due to periodontitis . * teeth with the procedural errors preventing access to apical third and missed canals will be excluded. * teeth that are not suitable for rubber dam isolation. * teeth with intraradicular post.

Keywords: nonsurgical retreatment, single visit multi visit, calcium hydroxide outcome
trunk control and disability in persons with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study aims to investigate the relationship between physical disability and trunk control, balance, and pedobarographic parameters in persons with relapsing remitting multiple sclerosis (rrms) who have a low expanded disability status scale (edss) score. twenty-three rrms patients with an age range of 18-50 years, edss score ≤ 3 were included in this study. the patients' level of disability (edss), trunk control )trunk impairment scale - tis), lower extremity functionality (timed 25-foot walk test - t25fw), upper extremity functionality (nine hole peg test- 9hpt), balance (biodex balance system) and gait (zebris® fdm 2) were evaluated.


Eligibility criteria:
inclusion criteria: * 18-50 years old, * diagnosed with rrms by an experienced neurologist * edss score ≤ 3 exclusion criteria: * orthopedic or sensory additional problems in the lower extremity * who had an interventional procedure in the last six months, and had an attack in the last three months
a study to develop molecular integrated predictive models of breast radio-toxicity (precise-rtox)

Conditions: Breast Cancer

Summary: breast radiation treatment is burdened by acute and chronic toxicities, in most cases mild. however, considering the excellent life expectancy of patients with breast cancer, maintaining a low toxicity profile is of primary importance in order to guarantee a satisfactory quality of life. the definition of the molecular and genetic variables related to radiotoxicity and their integration into predictive molecular signatures may allow the risk of toxicity to be individualized. this would provide the clinician with a useful tool in order to personalize the radiation treatment, thus being able to choose the best technique or schedule for each patient.

breast radiation treatment is burdened by acute and chronic toxicities, in most cases mild. however, considering the excellent life expectancy of patients with breast cancer, maintaining a low toxicity profile is of primary importance in order to guarantee a satisfactory quality of life. currently there are numerous predictive models of toxicity (normal tissue complication probability, ntcp) which are based on dosimetric and sometimes also clinical data. to date, they do not include individual genetic variability. however, it is believed that inter-individual variability may be responsible for up to 40% of actinic toxicity. multiparametric models that consider genetics, dose and clinical aspects probably better reflect the complexity of radiotoxicity than models that rely on a single parameter and it is possible to integrate such parameters using a machine learning approach. the definition of the molecular and genetic variables related to radiotoxicity and their integration into predictive molecular signatures would therefore allow the risk to be individualized. this would provide the clinician with a useful tool in order to personalize the radiation treatment, thus being able to choose the best technique or schedule for each patient.

Eligibility criteria:
inclusion criteria: * age ≥18 years; * ability to express appropriate informed consent to treatment; * distant nonmetastatic breast cancer; * histology: infiltrating nst(no special type)/lobular carcinoma or ductal carcinoma in situ; * stage: ptis; pt1-3 pn1-3 m0; * hormone receptors, her-2 status: any; * breast-conserving surgery. both the sentinel lymph node biopsy and axillary lymphadenectomy. negative surgical margins. * candidates for postoperative radiation treatment. exclusion criteria: * refusal of radiotherapy treatment (i.e., absence of signed informed consent); * previous radiation therapy at the same site; * concomitant chemotherapy with anthracyclines or taxanes; * inability to maintain treatment position; * partial breast radiotherapy (pbi); * male breast cancer; * mastectomy surgery.
the incidence and risk factors of neonatal hyperbilirubinemia in term and late-preterm chinese infants

Conditions: Hyperbilirubinemia, Neonatal

Summary: thirteen hospitals in china will participate in the study, which aims to provide data on serum bilirubin levels in the first 168 hr after birth in term and late-preterm neonates, and estimate the incidence of severe neonatal hyperbilirubinemia and the underlying causes. we hypothesize that the study can be value in identifying and implementing strategies for risk reduction.

neonatal hyperbilirubinemia resulting in clinical jaundice is a common problem among infants, particularly during the first weeks of life. information about the incidence and risk factors of neonatal jaundice is not available from china where is one of the highest countries of the incidence of severe neonatal hyperbilirubinemia.

Eligibility criteria:
inclusion criteria: term or late-preterm newborn infants with gas of ≥35 weeks and birth weights of ≥2,000 g were included. exclusion criteria: all sick newborn infants who were admitted to the intensive care unit.

Keywords: hyperbilirubinemia neonatal incidence risk factors
flapless emdogain in the treatment of periodontal residual pockets

Conditions: Chronic Periodontitis, Generalized

Summary: 48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. they had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for generalized periodontitis with at least 2 teeth with residual probing pocket depths (ppd) ≥5 and ≤8 mm, with bleeding on probing (bop). two teeth with similar ppd were randomized to receive re-instrumentation either with (test) or without (control) adjunctive flapless administration of emd. differences in the changes of ppd and bop from baseline to 6 and 12 months will be analysed, and the frequencies of pocket closure (ppd ≤4 mm and no bop) will be compared


Eligibility criteria:
inclusion criteria: * at least two residual pockets with probing pocket depth (ppd) ≥5 and ≤8 mm, * bleeding on probing (bop), * mobility ≤degree 1 and * no furcation involvement. exclusion criteria: * full mouth plaque score \>20%, * uncontrolled systemic disease, * history of malignant disease in the oral cavity or previous radiotherapy in the head or neck area, * pregnant or lactating females, * drug and alcohol abuse, * smoking \>10 cigarettes per day and * inadequate restorative therapy or malocclusion.
characterization of 24 hour spirometry profiles of inhaled bi 1744 cl and inhaled tiotropium bromide in patients with chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the study is intended to characterize the lung function profile of bi1744 in copd patients where patients will perform pulmonary function tests at regular intervals for 24 hours at the end of a 6 week treatment period. each patient will receive all four treatments.


Eligibility criteria:
inclusion criteria: * patients willing to participate with confirmed diagnosis of copd * 40 years of age or older * having a 10 pack year smoking history * able to perform serial pulmonary function tests * able to use both a dry powder inhaler (dpi) and respimat device exclusion criteria: * significant other disease * clinically relevant abnormal hematology, chemistry, or urinalysis * history of asthma * diagnosis of thyrotoxicosis * paroxysmal tachycardia related to beta agonists * history of mi within 1 year, cardiac arrhythmia, hospitalization for heart failure within 1 year * active tuberculosis, cystic fibrosis, clinically evident bronchiectasis * significant alcohol or drug abuse * pulmonary resection * taking oral beta adrenergics * taking unstable oral steroids * daytime oxygen * enrolled in rehabilitation program * enrolled in another study or taking investigational products * pregnant or nursing women, women of child bearing potential not willing to use two methods of birth control * those who are not willing to comply with pulmonary medication washouts
postoperative pain in patients undergoing scheduled laparoscopic intestinal resection surgery

Conditions: Postoperative Pain, Acute; Postoperative Pain, Chronic

Summary: this observational prospective study aims to evaluate the postoperative analgesic effect of a regional anesthesia thechnique (tap block) in patients undergoing scheduled laparoscopic intestinal resection for intestinal cancer. asa i-iii patients operated between may 1 and september 30, 2019 under general anesthesia according to usual clinical practice, will be included. patients who meet any of the following criteria will be excluded from this study: under 18 years old, language barrier, cognitive impairment or inability to assist in clinical assessment, drug or alcohol abuse, intake of opioids, consumption of analgesics 24 hours before surgery, bmi \ 35 kg/m2. subsequently, an analysis will be made evaluating the quality of analgesia and the appearance of postoperative chronic pain and comparing the patients who underwent tap block with those who did not.

the transverse abdominal plane (tap) block is a regional anesthesia technique that blocks the afferent nerves of the anterolateral abdominal wall. this observational prospective study aims to evaluate the postoperative analgesic effect in patients undergoing laparoscopic intestinal resection. asa i-iii patients operated on a scheduled basis, between may 1 and september 30, 2019, by laparoscopy for intestinal cancer resection under general anesthesia according to usual clinical practice, will be included. patients who meet any of the following criteria will be excluded from this study: under 18 years old, language barrier, cognitive impairment or inability to assist in clinical assessment, drug or alcohol abuse, intake of opioids, consumption of analgesics 24 hours before surgery, bmi \ 35 kg/m2. subsequently, an analysis will be made evaluating the quality of analgesia and the appearance of postoperative chronic pain and comparing the patients who underwent tap block with those who did not.

Eligibility criteria:
inclusion criteria: * asa i-iii * operated on a scheduled basis for laparoscopic intestinal cancer resection exclusion criteria: * under 18 years old * language barrier * cognitive impairment or inability to collaborate in clinical assessment during the study * drug or alcohol abuse * habitual intake of opioids * consumption of analgesics 24 hours before surgery * bmi \ 35 kg/m2
safety of riluzole in patients with acute spinal cord injury

Conditions: Spinal Cord Injury

Summary: the purpose of the study is to find out if the use of the drug riluzole is both safe and improves outcome in patients with acute traumatic spinal cord injury (sci).

the primary aim of the study is to develop acute care safety and pharmacokinetic profiles of riluzole in patients who have sustained a acute traumatic spinal cord injury. secondary objectives are to conduct exploratory analyses of functional outcomes for purposes of planning a subsequent phase ii randomized study of the efficiency of riluzole for the treatment of acute traumatic spinal cord injury.

Eligibility criteria:
inclusion criteria: * age equal to or greater than 18 years and less than or equal to 70 years; * willing to give written informed consent to participate in the study. the informed consent may require legally authorized representative to sign if arm/hand function is compromised. * no other life-threatening injury * spinal cord injury at the neurologic level from c4 to t12 * asia impairment scale level a, b or c * no cognitive impairment which would preclude an informed consent (including moderate or severe traumatic brain injury) * less than 12 hours since injury exclusion criteria: * equal or more than 12 hours since injury * hypersensitivity to riluzole or any of its components * unable to receive riluzole orally or via nasogastric tube * history of liver or kidney disease (e.g. hepatitis a, b or c, cirrhosis, etc.) * has a recent history of regular substance abuse (illicit drugs, alcohol) * unconscious * penetrating spinal cord injury * pregnancy as established by urine pregnancy test * breastfeeding * life expectancy less than 12 months * is currently involved in another therapeutic sci research study that precludes or complicates participation in this study (e.g. study of another therapeutic drug aiming for spinal cord injury recovery, any study that substantially interferes with the follow -up schedule (f/u) schedule, or any high risk study that complicates evaluation of safety outcomes. types of studies that would not preclude participation are e.g. behavioral adaptation studies, mental health interventions) * has a mental disorder or other illness, which in the view of the site investigator, would preclude accurate evaluation (e.g. schizophrenia, severe cognitive disability, parkinson disease) * unable to commit to the follow-up schedule * is a prisoner * unable to converse, read or write english at the elementary school level

Keywords: spinal cord injury riluzole pharmacokinetics acute traumatic spinal cord injury
treatment of the rotator cuff disease with platelet rich plasma injection

Conditions: Subacromial Impingement Syndrome; Partial Thickness Rotator Cuff Tear

Summary: the purpose of this investigator initiated study is to clinically evaluate the efficacy of a new treatment for subacromial impingement syndrome and partial thickness rotator cuff tears. this treatment consists of a platelet rich plasma injection into and around the rotator cuff. it is thought that this treatment will dramatically improve outcomes for patients suffering from these two conditions. subjects will be randomized by choosing a slip of paper from an envelope. this process will randomize 25 patients to the experimental group, and 25 patients to the control. the experimental group will undergo a blood draw, allowing for an injection of platelet rich plasma around the rotator cuff. the control group will undergo a corticosteroid injection into the subacromial space surrounding the rotator cuff as sole treatment. patients will be followed for three months for pain, and will fill out questionnaires at six weeks and three months post injection, which will give insight into functionality and pain changes that the rotator cuff is experiencing due to treatment. subjects will be outpatients. subjects may include employees, students, minorities, and elderly, although no subsets of these will be formed. subjects will be between 18 and 89 years of age. in total, subject participation will last approximately 3 months.


Eligibility criteria:
inclusion criteria: 1. patients presenting with rotator cuff symptoms for at least 4 weeks 2. examination reveals diffuse pain with provocative maneuvers 3. impingement symptoms with or without a partial thickness tear (if available mri study must be less than 50% tear) 4. willingness to participate in an investigational technique 5. willingness to forgo any other concomitant conservative treatment modality including nsaid (must be stopped for at least one week) exclusion criteria: 1. previous rotator cuff repair 2. complete rotator cuff tear or two tendon tears 3. pt w/ complex regional pain syndrome 4. cervical neuropathy or other nerve pathology 5. ra, local or systemic infection, pvd, metabolic disease such as gout, clotting disorder, anticoagulation therapy 6. evidence of intraarticular arthritis 7. work related or compensable injury 8. previous treatment: corticosteroid injection in the last 6 months 9. patients who are currently pregnant

Keywords: subacromial impingement partial thickness rotator cuff prp platelet rich plasma
effectiveness and safety of fast enteral feeding in preterm infants between 1000 and 2000 grams of birth weight

Conditions: Feeding Behavior

Summary: this is a randomized controlled trial with infants less than 34 weeks and between 1000 and 2000 grams at birth, that seeks to establish the safety and effectiveness of fast enteral advancement (milk 30-40 cc/kg/d) compared with traditional advancement (milk 20 cc/kg/d)

progression of enteral feeding in preterm infants is still controversial. the neonatologist needs to provide adequate caloric intake avoiding the risk of food intolerance and necrotizing enterocolitis. objective: to establish the safety and effectiveness of fast enteral advancement compared with traditional advancement. design: a randomized controlled clinical trial with infants less than 34 weeks and between 1000 and 2000 grams at birth conducted at hospital universitario san ignacio in bogotá, colombia. methods: 30 cc versus 20 cc / kg / day advancing in infants between 1000 and 1499g and 40cc versus 20 cc / kg / day advancing in infants between 1500 and 1999g. outcomes: days to reach full enteral nutrition, days of parenteral nutrition (pn) and/or intravenous fluids (ivf), days to regain birth weight, episodes of food intolerance, anthropometric measurements and weight gain at 40 weeks; rate of late onset sepsis, hypoglycemia, hyperbilirubinemia, necrotizing enterocolitis (nec) and mortality. data will be analyzed with student t test or mann-whitney u-test and pearson chi-square or fisher test. multiple linear regression will be performed. ethics: this protocol was approved by the ethics and research committee of pontificia universidad javeriana and san ignacio hospital. informed consent will be requested to parents.

Eligibility criteria:
inclusion criteria: * infants less than 34 weeks of gestational age. * weight at birth between 1000 and 2000 grams. * infants hospitalized in the newborn unit at hospital universitario san ignacio in bogotá, colombia. exclusion criteria: * perinatal asphyxia * intrauterine growth restriction * diagnosis of congenital hearth disease * severe hypoxemia * major congenital malformations * metabolic disease * intolerance to initiate oral feeding at the eligibility * patent ductus with hemodynamic instability * early onset sepsis with hemodynamic instability * refusal of parents to participate in the study

Keywords: enteral nutrition infant,premature feeding method
effective treatment of posttraumatic and postoperative edema

Conditions: Edema

Summary: edema control after ankle- and hindfoot fractures is important. multi-layer compression bandages or a-v impulse compression may are more effective in reducing edema than ice.

after ankle- and hindfoot fractures, edema has a major impact on the time point of surgical intervention and may increases the risk of wound complications and infection postoperatively. effective treatment of edema, therefore, is of great importance. the aim of this study was to evaluate the efficacy of the multi-layer compression therapy and of the a-v impulse compression (avi) in reducing ankle- and hindfoot edema as compared to the standard treatment with ice.

Eligibility criteria:
inclusion criteria: * age 18-65 years * inpatients * acute ankle- or hindfoot fractures (malleolar-, calcaneus-, talus-, and pilon- tibial fractures) including fractures temporary stabilized with an external fixator) * no walking aids before trauma * written informed consent * monotrauma * preoperative and/or postoperative edema * preoperative inclusion * if delay of surgery due to ankle edema * if fracture stable enough for temporary removal of orthesis exclusion criteria: * diabetes mellitus * lymphedema * peripheral arterial occlusive disease (pad) * decompensated heart failure or renal insufficiency * acute bacterial infection * severe osteoporosis * pathological fractures * known tumors * postthrombotic syndrome * thrombosis * open fractures * polytrauma, cerebral trauma * neurological deficiencies * diuretics * pregnancy * alcohol or drug abuse * psychological disorders

Keywords: edema reduction ice multi-layer compression bandage a-v impulse compression ankle
a follow-on study for second-eye treatment for participants previously treated with gene therapy for x-linked retinitis pigmentosa (xlrp)

Conditions: X-Linked Retinitis Pigmentosa

Summary: the purpose of this study is to assess the safety and tolerability of subretinal delivery of adeno-associated virus vector (aav5 hrkp.rpgr) gene therapy in adults and children with x-linked retinitis pigmentosa.


Eligibility criteria:
inclusion criteria: * have been treated with aav5-hrkp.rpgr in study mgt009 and have completed or is currently enrolled in study mgt010 * must sign an informed consent form indicating that they understand the purpose and procedures of the study and is willing to participate in the study * willing to adhere to the protocol and long-term follow-up exclusion criteria: - there are no specific exclusion criteria to enroll in this study