Kornimate/medical-research-clean huggingface dataset:
the safe study of routine closure of mesenteric defects versus non-closure after radical gastrectomy

Conditions: Gastric Cancer

Summary: to compare the incidence of internal hernia, overall survival and short-term surgical safety of routine closure of the surgically created mesenteric defects versus non-closure for patients with adenocarcinoma of the gastric or esophagogastric junction who underwent radical gastrectomy (d1+/d2 lymph node dissection).


Eligibility criteria:
inclusion criteria: * aged 18-75 years； * primary lesion is diagnosed with endometrial biopsy as adenocarcinoma of the stomach or esophagogastric junction, including: papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, poorly cohesive carcinoma (including signet ring cell carcinoma and other variants), mixed adenocarcinoma, etc.； * the gastric primary lesion is located in the antrum, body or fundus of stomach or the esophagogastric junction. it is expected that radical gastrectomy with d1+/d2 lymph node dissection achieves r0 resection (multiple primary cancers are also applicable)； * bmi(body mass index) \< 30 kg/m2； * no history of upper abdominal surgery (except for laparoscopic cholecystectomy)； * no prior treatment of chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc.； * preoperative ecog (eastern cooperative oncology group) performance status score 0 or 1； * preoperative asa (american society of anesthesiologists) scoring i-iii； * sufficient vital organ functions； * signed informed consent. exclusion criteria: * women during pregnancy or lactation； * suffer from other malignant tumors within 5 years； * preoperative body temperature ≥ 38°c or complicated with infectious diseases requiring systemic treatment； * severe mental illness； * severe respiratory disease； * severe liver and kidney dysfunction； * history of unstable angina or myocardial infarction within 6 months； * history of cerebral infarction or cerebral hemorrhage within 6 months； * continuous application of glucocorticoid within 1 month (except for topical application)； * accompanied by gastric cancer complications (bleeding, perforation, obstruction, etc.) ； * the patient has participated in or is participating in other clinical studies (within 6 months).
adult weight, genetics and lifestyle factors

Conditions: Obesity

Summary: childhood obesity leads to adulthood obesity, demonstrated in many retrospective and longitudinal studies. genetics as a predictor of obesity is less established. morandi et al, (2012) assessed whether lifestyle and genetic factors can be used to predict childhood obesity, concluding that genetics had minimal predictive effect. more recently seyednasrollah, (2017) demonstrated that genetic information, when alongside clinical factors for cardiovascular disease, increased the predictive accuracy of obesity risk in adults. this study aims to investigate if known lifestyle and genetic risk factors are associated with bmi and if they can be used as predictors of overweight/obesity in adults.


Eligibility criteria:
inclusion criteria: * european citizen. * aged between 18-65 years. * female. * caucasian exclusion criteria: * currently following a diet or weight loss plan or have not been for over 6 months of the previous year. * suffering from diabetes (type i or ii). * cancer, or have had cancer in the past.
pregnant women with placenta previa

Conditions: Placental Previa

Summary: placenta previa is the extension of placental tissue over the endocervical os or covering the cervical os. placenta previa is a common complication in the third trimester of pregnancy and is a major cause of postpartum hemorrhage and perinatal death.there are many studies in the literature on attachment. however, no studies have been found on fetal movement in placenta previa pregnant women. counting fetal movements is an easy and inexpensive assessment that pregnant women can do on their own, without the need for any specialist or equipment, and for which they take responsibility. it is assumed that the effective time spent during fetal movement counting will positively affect the attachment between the pregnant woman and the fetus, and that the stress of the pregnant woman, who is sure that her baby is well, will decrease.


Eligibility criteria:
inclusion criteria: * between the ages of 18-45 * in the second trimester, * primiparous, * with adequate communication skills * literate, * able to read and understand turkish, exclusion criteria: having any mental illness * having communication, hearing or vision problems that prevent you from answering the data collection tools

Keywords: fetal movement pecha kucha pregnancy distress placental previa
stabilometric assessment of balance recovery in persons with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: background: balance control relies on accurate perception of visual, somatosensory and vestibular cues. sensory flow is impaired in multiple sclerosis (ms) and little is known about the ability of the sensory systems to adapt after neurological lesions reducing sensory impairment. the aims of the present study were to verify whether: 1. balance rehabilitation administered in a challenging sensory conditions would improve stability in upright posture 2. the improvement in a treated sensory condition would transfer to a non treated sensory condition. methods: fifty three persons with multiple sclerosis, median (min-max) expanded disability status scale score of 5 (2.5-6.5), participated in a randomized controlled trial and were randomly assigned to two groups. the experimental group received balance rehabilitation aimed at improving motor and sensory strategies. the control group received rehabilitation treatment which did not include training of sensory strategies. persons with multiple sclerosis were blindly assessed by means of a stabilometric platform with eyes open, eyes closed and dome, on both firm surface and foam. anterior-posterior and medio-lateral sway, velocity of sway and the length of center of pressure (cop) trajectory were calculated in the six sensory conditions.


Eligibility criteria:
inclusion criteria: * clinically or laboratory definite relapsing-remitting, primary or secondary progressive ms exclusion criteria: * inability to stand independently in upright position for 30 seconds * inability to walk for 6 m even with an assistive device

Keywords: rehabilitation, balance, sensory strategies, multiple sclerosis, postural control
brain, obesity, dopamine and you study

Conditions: Obesity

Summary: central dopamine is thought to play a significant role in obesity. in support of this idea, animal studies and one human positron emission tomography (pet) study have found reduced postsynaptic d2-like receptor availability in the striatum in obesity, with lower d2 receptor availability associated with higher weight. in addition, reward sensitivity and hedonic responses, known to be related to dopamine function, have also been implicated in obesity and obesity-related eating behavior. these reports have led to the concept that dopaminergic abnormalities (e.g. reduced d2-like receptors) influence reward sensitivity, leading to altered eating behaviors and eventually obesity. however, there are several critical limitations of the human d2 receptor studies that limit the strength of their conclusions and thus the interpretations and speculations embedded in literature that relies on this work. first, estimates of d2-like receptors in humans have been confounded by potential differences in endogenous dopamine release since the pet ligand (raclopride) used is known to be displaceable from receptors by endogenous dopamine. second, failure to rigorously screen obese individuals for diabetes confounds conclusions, since diabetes has been independently associated with dopaminergic abnormalities such as reduced d2-like receptors and muted dopamine release in diabetic rats. finally, no human studies have addressed whether reduced d2-like receptor levels are a risk factor for obesity, a consequence of engaging in obesity-related behaviors or being obese or all of the above.


Eligibility criteria:
inclusion criteria: * 41 obese adults (bmi 33 kg - 45 kg.) * 24 lean adults (bmi 18.5 kg - 24.9 kg.) exclusion criteria: * subjects who are: 1. smokers, 2. pregnant or lactating, postmenopausal, 3. have diabetes or impaired oral glucose tolerance (fasting blood glucose level of \< 100 mg/dl and a 2 hour post-glucose challenge plasma glucose level of \< 140mg/dl, per ada criteria; ada 2004), 4. significant organ system dysfunction, anemia (hb \<10 g/dl), 5. take medications that could influence the study results, any history of dopamine agonist or antagonist treatment (e.g. neuroleptics or metoclopramide), 6. parkinsonism on exam, 7. borderline or lower iq (\<80 full scaled score), or 8. any psychiatric or neurologic illness (e.g. drug abuse, parkinson disease, tourette syndrome, stroke) that could affect the interpretation of the data, compliance or completion of the study will be excluded. specific psychiatric exclusions are lifetime psychosis, current mania, substance dependence, major depression, social phobia, tic disorders, eating disorders and panic disorder. dysthymia will not be excluded, but levels of depression will be measured with the bdi for future exploratory analysis. * lean subjects will be excluded for being obese in the past (based on maximum bmi not related to pregnancy).

Keywords: obesity
a multi-center study for eradication of helicobacter pylori with triple therapy using clarithromycin

Conditions: Gastritis

Summary: as the resistant rate of the helicobacter pylori to some common antibiotics was rising，the eradication rate of the helicobacter pylori with the standard triple therapy failed to exceed 70% in china，and had to drop out of the first-line treatment recommendations. however, with the increase of treatment time, patients burden, adverse reactions of antibiotics or proton pump inhibitor (ppi) will also increase. resistance to clarithromycin is the major cause of the failure to eradicate helicobacter pylori. but, in terms of population, there are still more than 70% of the patients with clarithromycin sensitive. under the guidance with susceptibility test，7-day standard triple therapy could be used. in this study, investigators will select the patients with infection of h. pylori and with clarithromycin sensitive. eradication of helicobacter pylori with triple therapy based on accurate susceptibility testing of clarithromycin will be studied. the treatment time will be assigned into 7 days,10 days and 14 days groups. then, investigators will perform a sequencing for failed treatment patients in groups, such as drug resistance gene mutation, phenotype and genotype. finally, investigators will compare the differences between the patients with triple therapy and traditional quadruple therapy.the incidence of adverse effects in the eradicate treatment will reduce at least 10% and avoid patients' unnecessary economic losses at least 400rmb per person.


Eligibility criteria:
inclusion criteria: 1. age 18\~70 years old, male or female, the first eradication therapy of h. pylori infection patients. 2. symptoms of abdominal pain, bloating, acid efflux, belching, nausea, vomiting, heartburn, chest pain, vomiting, melena, etc. 3. unused antibiotics, bismuth, h2 receptor antagonists or ppi by nearly 4 weeks 4. 13c-labelled urea breath test positive. 5. agreed to helicobacter pylori culture and sensitivity testing taken by endoscopy gastric biopsy specimens,and the result of culture was positive. 6. agreed to helicobacter pylori eradication therapy and cooperate with the eradication efficacy follow-up survey. exclusion criteria: 1. severe heart, liver, kidney dysfunction. 2. pregnant or lactating women. 3. complications of bleeding, perforation, pyloric obstruction, cancer. 4. within 3 months before with the drugs involved in other drugs research. 5. esophageal,gastrointestinal surgery history. 6. patients can not properly express their complaints,such as psychosis, severe neurosis. 7. taking nsiad or alcohol abusers. 8. allergic to amoxicillin or clarithromycin tested by susceptibility testing.

Keywords: helicobacter pylori antibiotic resistance sequencing
acoart iv / sfa in china:drug-eluting balloon for sfa angioplasty evaluation in china

Conditions: Peripheral Artery Disease

Summary: the registry is a prospective, multicenter, single arm post-market real-world registry in china assessing the clinical use, safety and outcomes of the orchid 035 dcb catheter in the superficial femoral artery (sfa) and popliteal arteries (pa).

pta is an established alternative to open surgical bypass for the treatment of infrainginual disease of critical limb ischemia. debs are designed to promote arterial patency by reducing neointimal proliferation.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * patients with peripheral artery disease (pad), with rutherford classification between 2 and 5 * an occlusion or a minimum grade of stenosisprimary over 70% in the superficial femoral artery an /or the popliteal artery * total length of treat lesion(s)is less or equal to 20cm * signed patient informed consent form exclusion criteria: * plasma cr level greater than 150 umol/l in patients * patients with acute thrombosis requiring lysis or thrombectomy * 2 or more than 2 stenosis lesions in traget vessel * patient with a lysis or an lower limb intervention as a therapy within the last 6 weeks * patient requiring intervention in both lower limbs at the same time * have \>30% residual stenosis or blood-limited dissection after predilation * distal outflow through less than one lower leg vessel * known hypersensitivity to aspirin, heparin, clopidogrel,paclitaxel, contrast medium, etc. * patients participating in another clinical trials with interfere with this trial in the past 3 months * pregnancy and lactating woman * untreatable bleeding diatheses * other diseases, such as cancer, liver disease, or cardiac insufficiency, which may lead to protocol violations or markedly shorten a patients's life expectancy(less than 1 years) * patients unable or unwilling to participate this trial

Keywords: drug-coated balloon
cow's milk elimination for treatment of eosinophilic esophagitis

Conditions: Eosinophilic Esophagitis

Summary: the investigators seek to assess the efficacy of removing cow's milk from an eoe patient's diet. this will be determined by esophageal inflammation and clinical and histological response to the milk elimination treatment.

the dietary approach is based on the hypothesis that food antigen(s) trigger eosinophilic inflammation and clinical and histological remission can be induced by identifying and excluding the causative food antigen(s). it is believed that eliminating causative food antigen(s) target the cause and thus induces long term remission. this process is difficult as it requires multiple, invasive endoscopies and introduces the possibility of iatrogenic effects such as nutrient deficiency due to simultaneous multiple food eliminations. in addition, patient compliance may be compromised, both intentionally and unintentionally as many families report the elimination process to be both confusing and frustrating. this prospective study eliminating only cow's milk proteins, which are a common cause of esophageal inflammation in patients with eosinophilic esophagitis, will assess the histological response in a cohort of children receiving care at lurie children's.

Eligibility criteria:
inclusion criteria: * patients aged 1-18 * patients who meet the criteria for diagnosis of eoe with ≥15 eosinophils per high power field and who had been previously treated with an adequate dose of ppi for 6-8 weeks or had a normal 24 hour ph probe study will be recruited from the patients seen by one of the physicians in the eoe clinic at lurie children's and other participating centers * patients who agree to cow's milk elimination diet as their treatment of eoe exclusion criteria: * patients who started on oral or swallowed steroids (prior use of steroids that was discontinued more than two months prior to enrollment does not constitute an exclusion criterion) * patients who are unable to tolerate the cow's milk elimination diet * patients with concurrent eosinophilic gastroenteritis or eosinophilic colitis
parasternal subpectoral plane blocks for cardiac surgery via a midline sternotomy

Conditions: Pain, Postoperative

Summary: to better determine whether parasternal subpectoral plane blocks (pspb) infusing bupivacaine for midline sternotomy decreases opioid consumption and pain scores. this is a prospective, blinded randomized controlled trial with 2 arms. 1 arm is the saline control arm, pspb catheters will be placed with saline and continue to infuse saline. the other arm is bupivacaine study arm, pspb catheters will be placed with bupivacaine and continue to infuse the local anesthetic.

subjects will be randomized to receive pspb catheters infusing either bupivacaine or saline. randomization will be achieved using a computer-generated randomization scheme. the surgeon, nurse, anesthetist and patient will be blinded. the investigational drug service will prepare blinded solutions (bupivacaine 0.2% or saline syringes) for performance of the block. they will also prepare bags (either bupivacaine 0.125% or saline) to be infused through the catheter. following skin closure, but before removal of the surgical drapes, regional anesthesiologists will scrub in, gown and perform the placement of pspb catheters under strict surgical aseptic technique. real-time ultrasound (us) imaging will be used to visualize the pectoralis major muscle and its corresponding rib cartilages, and a needle/introducer sheath will be guided parasternally into the fascial plane. the needle will be advanced in the plane, hydro-dissecting with 30 ml of bupivacaine 0.2% in the study group or 30 ml of saline in the control group per side. following hydro-dissection, a 5 in. multiport catheter will be inserted via the sheath, and the catheter will be secured following us confirmation of appropriate catheter position. this procedure will then be repeated on the other side. after completion of bilateral pspb catheters, patients will remain intubated and be transferred to the csicu on a sedation regimen at the discretion of the intraoperative anesthesia team. upon dropping off to the icu, each catheter will be attached to a programmable pump infusing plain bupivacaine 0.125% at 10 ml/hr or saline infusing at 10 ml/hr. once again, the solution to be infused postoperatively will be prepared by pharmacy and blinded from the patient, nurse, and postoperative pain service providers.

Eligibility criteria:
inclusion criteria: 1. male or female 2. aged 18 - 80 years 3. scheduled for primary elective cardiac surgery via median sternotomy 4. willingness to undergo psychosocial testing 5. willingness to participate in long-term follow up 6. willingness to be randomized to receive local anesthetic or saline infusion through pspb catheters 7. access to an email and computer exclusion criteria: 1. allergy to opioids 2. allergy to bupivacaine 3. emergency surgery 4. unable to provide informed consent 5. weight less than 50kg
a safety and tolerability study of paliperidone palmitate injected in the shoulder or the buttock muscle in patients with schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to evaluate the safety and tolerability of intramuscular injections (to the buttocks or to the shoulders) of paliperidone palmitate in patients with schizophrenia.

to date, all prior trials involving intramuscular injection of paliperidone palmitate were conducted with buttock administration. this is a randomized, multicenter, crossover design study in evaluating safety and tolerability of paliperidone palmitate in two different injection sites. the study hypothesis is that there will be no difference in safety and tolerability between buttock injection compared to shoulder injection at any of the three different doses of paliperidone palmitate. the patients will receive intramuscular injections of paliperidone palmitate in either their buttocks or in their shoulders

Eligibility criteria:
inclusion criteria: * the patient must have signed an informed consent * the patient must meet the diagnostic criteria for schizophrenia * female patient must be postmenopausal for at least 2 years or have negative pregnancy test result at screening * the patient must be able to perform study requirements (e.g. answer questionnaire) exclusion criteria: * primary, active diagnosis other than schizophrenia * psychiatric inpatient hospitalization for relapse of symptoms of schizophrenia in the past 90 days * change in their antipsychotic medication in the past 45 days * diagnosis of active substance dependence within 3 months * history of treatment resistance * history of concurrent significant or unstable diseases (e.g. heart, lung, or liver diseases)

Keywords: schizophrenia intramuscular injection deltoid muscle gluteus muscle paliperidone palmitate
the effect of probiotics on infections in toddlers

Conditions: Diarrhoea; Respiratory Diseases

Summary: probiotics has been known as a dietary supplement for a long period. recent clinical trials indicate that probiotics might have an effect in preventing common infection diseases in children. the investigators hypothesis is: if young children in the age of 6 month to 15 mdr. has a daily intake of a suspension containing probiotics in a period of 9 months, the incidence of diarrhoea and respiratory diseases can be reduced.

probiotics has been known as a dietary supplement for a long period. recent clinical trials indicate that probiotics might have an effect in preventing common infection diseases in children. our hypothesis is: if young healthy children in the age of 6 month to 15 mdr. has a daily intake of a suspension containing probiotics( bb12 and th4) in a period of 9 months, the incidence of diarrhoea and respiratory diseases can be reduced.

Eligibility criteria:
inclusion criteria: * healthy children born in university hospital holbaek,hospital north,region zealand, denmark in the period of jan. 2009 to oct. 2010 * gestational age \> 36. weeks exclusion criteria: * chronical heart or lung conditions * short bowel syndrome * cvc (central venous catheter)

Keywords: probiotics infections children