Kornimate/medical-research-clean huggingface dataset:
meriter mindfulness training for smokers program and study

Conditions: Smoking

Summary: the meriter smoking cessation study tests participants in the meriter smoking cessation program. meriter hospital and clinic patients will be recruited into the meriter smoking cessation program. the meriter smoking cessation program has two interventions, the mindfulness training for smokers (mts) intervention and the quit line (ql) intervention. study activities include one 10-minute study visit and two 5-minute survey phone calls.

the meriter smoking cessation study tests participants in the meriter smoking cessation program. meriter hospital and clinic patients will be recruited into the meriter smoking cessation program. the meriter smoking cessation program has two interventions, the mindfulness training for smokers (mts) intervention and the quit line (ql) intervention. study activities include one 10-minute study visit and two 5-minute survey phone calls. mts: mindfulness training for smokers intervention. this is the 7-week quit smoking intervention developed by the pi. ql: quit line intervention. this is a program starting at makes use of the wisconsin tobacco quit line. meriter smoking cessation program: a program offering the mts and ql interventions to smokers at meriter hospital and clinics. meriter smoking cessation study: this is a study comprised of 2 phone surveys and 1 study visit that tests participants in the mts and ql intervention. participants in the meriter smoking cessation program will have the opportunity to decide if they would like to be in the study.

Eligibility criteria:
inclusion criteria: * everyday smoker exclusion criteria: * current alcohol or other drug addiction

Keywords: smoking tobacco addiction mindfulness meditation
effect of myofunctional therapy on osa

Conditions: Obstructive Sleep Apnea

Summary: the primary medical therapies for patients with obstructive sleep apnea syndrome (osa) require the use of medical devices on a nightly basis to help control breathing during sleep, which can be difficult for patients with mild-to-moderate disease. because many patients use these therapies on a limited basis, or stop using them altogether, they continue to be at increased risk of the consequences of untreated osa. untreated and undertreated osa compounds the risk of osa consequences over time, particularly with increasing age and weight. orofacial myofunctional therapy (omt) takes a rehabilitative approach to osa and is comprised of isotonic and isometric exercises that target the oral (e.g., tongue) and oropharyngeal (e.g., soft palate, lateral pharyngeal wall) to help restore normal breathing and airway patency at night while asleep. should the study have positive findings, omt could become an important alternative therapy for patients with mild-to-moderate disease because patients could utilize a therapy that improves their nighttime breathing through daytime exercises and without the need for a burdensome medical device.

the purpose of this study is to examine the effect of orofacial myofunctional therapy in veterans with mild-to-moderate sleep apnea. the main question to be answered is whether omt improves measures of osa severity, patient functional status, and osa symptoms when compared to sham omt.

Eligibility criteria:
inclusion criteria: * mild-to-moderate osa * entry criteria are as inclusive as possible and operationalized as follows: age\>18 years old * confirmed diagnosis of osa * having chronic symptoms per screening symptom checklist * fluency in english * must be getting care the va san diego healthcare system exclusion criteria: * cognitive impairment sufficient to cause inability to complete the protocol (per medical chart review) * low health literacy * residence in a geographical area outside of san diego county * fatal comorbidity (life expectancy \<6 months as indicated by treating physician) * significant documented substance/chemical abuse

Keywords: sleep apnea myofunctional therapy chronic disease
multiple myeloma prognostic indices

Conditions: Multiple Myeloma; Hematologic Diseases

Summary: the aim of this study was to evaluate the impact of albumin / fibrinogen ratio, blood viscosity and rdw on the prognosis of a newly diagnosed mm patients

multiple myeloma (mm) is a hematologic neoplasm of plasma cells that arises in the bone marrow, manifest by bone pain, pathologic fractures, anemia, renal insufficiency and recurrent infections. treatment options include chemotherapy (proteosome inhibitors), targeted therapy, autologous stem cell transplantation and supportive care. mm has numerous prognostic factors affecting patient outcomes, some of the most important prognostic factors include age, stage of disease, levels of certain proteins like beta -2 microglobulin, albumin, chromosomal abnormalities and renal function tests. in addition to albumin / fibrinogen ratio, blood viscosity and hematologic indices which are mainly focused on through this research . the albumin / fibrinogen ratio has been recently studied as a potential prognostic factor for newly diagnosed mm patients, fibrinogen is the protein that plays a role in blood clotting, while albumin helps regulate fluid balance in the body. studies show that a higher albumin/ fibrinogen ratio is associated with a better prognosis of mm, however, further studies is necessary to fully understand the impact of this ratio on mm prognosis. blood viscosity is the measure of the thickness and stickiness of the blood, which can impact blood flow and oxygen delivery to vital organs. newly diagnosed mm patients, higher whole blood viscosity is associated with a poorer prognosis and shorter survival times. increased viscosity may contribute to the development of blood clots and impaired circulation, leading to tissue damage and organ failure, however, further studies is needed to better understand the mechanism underlying this relationship and develop targeted interventions to improve outcomes. several studies have shown that radial distribution width (rdw) can serve as a prognostic factor in the newly diagnosed mm patients. this index can provide important information about patients' immune response, inflammation and overall health status. a high rdw are associated with poor prognosis. however, further studies is necessary to fully understand the impact of these indices on mm prognosis.

Eligibility criteria:
inclusion criteria: * patients newly diagnosed with mm according to international myeloma working group criteria 2016. exclusion criteria: * patient previously diagnosed mm and started treatment or in post treatment follow up
china red eye study on allergic conjunctivitis

Conditions: Allergic Conjunctivitis

Summary: this study is the first multi-center cross-sectional study on the diagnosis and misdiagnosis of allergic conjunctivitis in the ophthalmology clinic in china. it provides a clinical basis for the standardized diagnosis and treatment of allergic eye diseases.

allergic conjunctivitis is a common disease in ophthalmology. the european allergy association, japan, the united states and other countries have clear diagnostic criteria or guidelines for the definition and diagnosis of allergic diseases and allergic conjunctivitis. however, china is currently lacking related guidelines. allergic conjunctivitis has some of the same symptoms and signs as other infections/non-infectious conjunctival inflammation. when the symptoms and signs are atypical, it is prone to missed diagnosis and misdiagnosis, resulting in prolonged disease duration, drug abuse and waste of medical resources. the current abuse of antibiotics is considered to be a huge problem in the treatment of ocular surface diseases. a study in our country believes that the rate of misdiagnosis of dry eye is as high as 66.2%, and most of them are misdiagnosed as chronic conjunctivitis, resulting in frequent using a variety of antibiotic eye drops. at present, the misdiagnosis of allergic conjunctivitis and the abuse of antibiotics caused by misdiagnosis in china are still unclear, therefore clinical research is urgently needed. we intend to use this study to understand the status of diagnosis and treatment of allergic conjunctivitis in china, and provide clinical evidence for the standard diagnosis and treatment of allergic eye diseases.

Eligibility criteria:
inclusion criteria: * patients whose clinical diagnosis is allergic conjunctivitis. exclusion criteria: * the investigator believes that there are any unsuitable reasons for participating in the trial.

Keywords: misdiagnose mistreatment antibiotics
powerly - science-based digital intervention preventing postpartum depression and anxiety

Conditions: Stress; Postpartum Depressive Disorder; Postpartum Anxiety

Summary: the goal of this clinical trial is to determine if the powerly app can help prevent postpartum depression and anxiety in healthy pregnant women. the main questions it aims to answer are: * does the powerly app reduce postpartum depression and anxiety? * does it improve emotion regulation and maternal bonding with a child? researchers will compare two groups: one using the powerly app and the other receiving care as usual (cau) to see if the app leads to better mental health outcomes. participants will: * use the powerly app for four weeks (if in the intervention group). * complete mental health assessments before the study, after four weeks, and six weeks postpartum.

pregnancy is a period of significant emotional and physical changes, with up to 30% of expecting mothers experiencing high stress. after birth, around 15-20% of new mothers suffer from postpartum depression, and 25-35% experience anxiety. despite broad availability of mobile apps aimed at these challenges, none of them have been rigorously tested through clinical studies. to fill this gap, we developed powerly, a science-based mobile app designed to help prevent postpartum depression and anxiety. in this study, 140 healthy pregnant women will be randomly assigned to one of two groups: one will use the powerly app for four weeks, while the other will receive care as usual (cau). powerly is grounded in cognitive behavioral therapy (cbt) and personalized to the individual's needs, with input from healthcare professionals and pregnant women. we will collect information on participants\&#39; mental health at three points: before they start using the app, after four weeks of app use / cau, and six weeks after giving birth. the app's effectiveness will be evaluated by examining improvements in mental health outcomes, such as reduced rates of postpartum depression and anxiety, better emotion regulation, and stronger maternal bonding with a baby.

Eligibility criteria:
inclusion criteria: * being between 24 and 32 weeks pregnant, * owning an iphone, * having sufficient fluency in german language exclusion criteria: * high-risk pregnancies, * history of substance abuse and psychiatric disorders such as bipolar disorder, schizophrenia, or other psychotic disorders, * current use of professional face-to-face psychotherapeutic support, * participation in other clinical trials or interventions at the same time

Keywords: pregnancy postpartum depression postpartum anxiety stress digital health mobile health ecological momentary intervention
goal directed fluid management based on non-invasive monitoring

Conditions: Postoperative Complication

Summary: the purpose of this study is to evaluate whether goal directed fluid management using respiratory variations in the oxygen saturation by pulse oximetry (spo2) waveform has potential to decrease postoperative complications and outcomes.

the aim of this study is to test the hypothesis that monitoring and minimizing the respiratory variations in the pulse oximeter waveform amplitude by volume loading has potential to decrease postoperative morbidity and length of stay in the hospital in patients undergoing routine, moderate-risk elective surgery. in this study the investigators will test the impact of hemodynamic optimization based on the respiratory variations in the plethysmographic waveform amplitude to decrease postoperative morbidity and length of stay in the hospital in patients undergoing routine, moderate-risk elective surgery. the primary outcome variable is the incidence of postoperative complications. secondary outcome variables are the duration of hospital and icu stays, postoperative mortality, and cost of surgery.

Eligibility criteria:
inclusion criteria: * patients (male or female) * over 18 years old undergoing non-cardiac surgery * weight \> 40 kg, body mass index \< 40 exclusion criteria: * patients who do not consent * body mass index \> 40

Keywords: goal-directed fluid therapy
meal texture and satiety

Conditions: Healthy Normal Weight

Summary: the aim of the present study is to compare the nutritional compensation between iso-caloric meals of various textures (liquid vs solid) in health young adults.

the present study will compare the potential energy intake compensations, appetite feelings response, food reward variations and satiating responses after the ingestion of three different lunch meals: i) one classical cooked meal; ii) one iso-energetic meal consumed using a pre-prepared liquid meal; iii) one iso-energetic meal consumed using a prepared liquid meal. this will be the first study to assess all these nutritional factors after such meals.

Eligibility criteria:
inclusion criteria: * being aged 18 to 25 years old * being normal weight with a bmi between 20 and 25 kg/m² * being registered with a social security number exclusion criteria: * eating disorders * specific food allergies or habits * being under diet

Keywords: meal texture appetite energy compensation food reward
long-term outcome after gestational diabetes and diabetes in pregnancy

Conditions: Diabetes, Gestational; Pregnancy Diabetic

Summary: the primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring. in addition, the long-term changes on the health of the affected mothers will be investigated, taking into account the metabolic adjustment during index pregnancy. the expected results will help to establish possible prevention strategies to fight the epidemic of non-communicable diseases for the offspring and the mothers.

investigation of the long-term outcome of mother-child pairs after diabetic pregnancies and a comparison group regarding metabolic, cardiovascular, neurocognitive and reproductive long-term changes as a function of the course of pregnancy and metabolic control

Eligibility criteria:
inclusion criteria: * for the pilot project: initial participation in the preliminary study * written informed consent * singleton pregnancies * delivery at the university hospital jena exclusion criteria: * severe physical and mental illness * patients who refuse to participate in the study or drop out * premature birth, i.e. birth of the child \<37/0 weeks of gestation * serious pregnancy complications * prenatally known serious malformations
the impact of cyp2d6 polymorphism on tramadol pharmacodynamics

Conditions: Post-cesarean Pain; CYP2D6 Polymorphism; Tramadol Resistance

Summary: cyp2d6 is an enzyme involved in the hepatic metabolism of many clinically important drugs: antiarrhythmics, antidepressants, antipsychotics, β-blockers, and analgesics such as tramadol and codeine. cyp2d6 is highly polymorphic and significant interindividual variability has been observed worldwide. this study aims to investigate the distribution of cyp2d6 polymorphisms among post-cesarean female patients in erbil city, iraq. the findings of this study may indicate the presence of cyp2d6 gene variants among the kurdish female population in erbil, which could contribute to tramadol analgesic failure or exaggerated adverse effects. this study could also serve as a foundation for further pharmacogenetic research, individualizing treatments and targeting a larger sample size in the future.


Eligibility criteria:
inclusion criteria: * female patients aged between 18-56 years old * patients who undergo cesarean section surgery * patients receive tramadol drug for postpartum pain management exclusion criteria: * patients with any history of severe renal, liver, respiratory diseases and/or seizures * patients with history of psychiatric disorders or unable to provide consent * patients with complicated surgeries or neonatal distress or unable to perform the clinical assessment of pain * patients with history of consumption of chronic alcohol or opioid or drug abuse * patients with history of known allergy to tramadol
pubourethral ligament plication for the surgical treatment of stress urinary incontinence

Conditions: Urinary Incontinence; Pelvic Floor Disorders

Summary: to test efficacy and safety at six months of the proposed pubourethral plication procedure (ppp) for cure of stress urinary incontinence - reinforcing pubourethral ligaments (pul) with large diameter polyester sutures.

full thickness vaginal incisions will be made in the suburethral sulci extending from bladder neck to urethral meatus. the operation space is 2.5cm2 space. a no2 or 3 polyester suture will be inserted into pul, immediately lateral to midurethra, into pul origin, external urethral ligament, laterally into m.pubococcygeus, then will be tied, but not tightly. the vaginal incisions will be closed with vicryl sutures. all women will be discharged on day of surgery. during the regular follow ups the healing at stress urinary incontinence will be evaluated

Eligibility criteria:
inclusion criteria: * urine loss on coughing controlled by hemostat behind symphysis exclusion criteria: * no exclusion criteria
the impact of a continuous performance task on the stress response

Conditions: Stress

Summary: the goal of this clinical trial is to learn about the impact of taking a continuous performance attention test on the physiological stress response in college students. the main questions it aims to answer are: * does taking an attention test cause participants to have increases in heart rate, blood pressure, and sweat? * does taking an attention test cause participants to have a decrease in heart rate variability? * are there relationships between participants' levels of anxiety, perceived stress, and mindfulness to their physiological changes? participants will * answer questionnaires about anxiety, stress, and mindfulness * have baseline measurements taken for blood pressure, sweat, and heart rate variability * take the pebl continuous performance task (a 14 minute attention test) while having the measurements listed above taken again

the pebl continuous performance task is an example of a mental stressor which requires vigilance and effort. we hypothesize that a sympathetic nervous system response will be evident in comparing physiological parameters during the attention task versus the preceding resting baseline period. exploratory analyses will assess relationships between psychological measures of anxiety, stress, and mindfulness with this physiological response and the number of errors on the attention test.

Eligibility criteria:
inclusion criteria: * english language proficiency * first year, first semester student enrolled in students together empowering peers course at the university of redlands exclusion criteria: * severe mental health issues * currently taking anti-anxiety medication

Keywords: stress anxiety blood pressure skin conductance level heart rate variability attention
percutaneous microwave ablation under ultrasound guidance for liver cancer: a multicenter analysis

Conditions: Liver Neoplasms

Summary: ultrasound-guided percutaneous mwa of liver cancer is a relatively new technique with favorable long-term outcomes.butthe results are mainly from single center reports.a larger scale data need to be analyzed to evaluate the technique. this study is designed to investigated the efficacy of cooled-tip microwave ablation (mwa) for primary liver cancer (plc) and analyzed the prognostic factors on a multicenter database.between january 2013 and december 2018, all the plc patients underwent ultrasound-guided percutaneous cooled-tip mwa as a primary treatment will be enrolled from at least ten chinese institutions with different levels of mwa experience. all the patients will be closely followed up until june 2019. clinicopathologic data, recurrence and survival estimates, complications and prognosis-relative factors will be measured.


Eligibility criteria:
inclusion criteria: * absence of ascites or the depth of ascites on us detection less than 4 cm; * a normal serum total bilirubin level or less than 60 µmol/l; * a normal albumin level or not less than 30 g/l; * for radical treatment, single lesion of 8 cm or smaller, three or fewer multiple lesions with a maximum diameter of 4 cm or less, absence of portal vein cancerous thrombus or extrahepatic metastases; * for palliative treatment, those with large or multiple lesions, suffering multiple metastases and unsuitable for other modalities can be considered to undergo the mwa on the condition of good hepatic function and blood coagulation function to tolerate the procedure. exclusion criteria: contraindications include patients who have 1. clinical evident liver failure, such as massive ascites or hepatic encephalopathy or with a trance-like state; 2. severe blood coagulation dysfunction (prothrombin time of more than 30 seconds, prothrombin activity less than 40%, and platelet count less than 30 cells×109/l); 3. high intrahepatic tumor burden (tumor volume \>70% of the target liver volume or multiple tumor nodules) or high extrahepatic tumor burden; 4. acute or active inflammatory and infectious lesions at any organ; 5. acute or severe chronic renal failure, pulmonary insufficiency or heart dysfunction; 6. relative contraindication concerns medical risk for the tumor proximity to diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels, which may require adjunctive techniques to prevent off-target heating of adjacent structures during the ablation procedure.

Keywords: multicenter study microwave