Kornimate/medical-research-clean huggingface dataset:
comparison of clopidogrel versus ticagrelor therapy for atherosclerotic plaque inflammation

Conditions: Plaque, Atherosclerotic

Summary: objectives: to compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial fdg pet/ct imaging of carotid artery and ascending aorta. hypothesis: thrombosis and inflammation are tightly linked rather than separate entities. therefore, p2y12 receptor inhibitors may have an anti-ischemic effect by inhibiting plaque inflammation, and ticagrelor may be superior in efficacy to clopidogrel.


Eligibility criteria:
inclusion criteria: * men or women at least 18 years of age inclusive * patients with acute coronary syndromes (unstable angina pectoris braunwald class ib, ic, iib, iic, iiib, iiic, nstemi or stemi) * fdg pet/ct shows at least 1 hot uptakes at carotid and or ascending aorta * the patient or guardian agrees to the study protocol and the schedule of clinical and fdg pet/ct follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethical committee of the respective clinical site. exclusion criteria: * patients treated with carotid endarterectomy or stent placement * chronic disease requiring treatment with oral, intravenous, or intra-articular corticosteroids (use of topical, inhaled, or nasal corticosteroids is permissible). * untreated hyperthyroidism, or hypothyroidism * any clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the investigator, would preclude safe completion of the study. * evidence of congestive heart failure, or left ventricular ejection fraction \< 40%. * significant renal disease manifested by serum creatinine \> 2.0mg/dl, or creatinine clearance of \< 40 ml/min (by cockcroft-gault method). * hepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation (alt or ast \> 3 times upper limit of normal). * history of adult asthma manifested by bronchospasm in the past 6 months, or currently taking regular anti-asthmatic medication(s). * unwillingness or inability to comply with the procedures described in this protocol. * patient's pregnant or breast-feeding or child-bearing potential. * type i diabetes

Keywords: plaque, atherosclerotic clopidogrel ticagrelor fluorodeoxyglucose f18 positron-emission tomography and computed tomography
anemia etiology evaluation in ethiopia

Conditions: Anemia

Summary: the anemee study is a population-based anemia etiology survey in six regions of ethiopia. the primary aim of the study is to evaluate the relative contribution of risk factors for anemia among children, women of reproductive age, and adult men. the study data are intended to inform evidence-based decision-making on anemia control interventions.

the anemee study is a population-based cross-sectional survey of children (6-59 months), adult women of reproductive age (15-49 years) and adult males (15-49 years) in six regions of ethiopia (afar, amhara, tigray, oromia, southern nations, nationalities and peoples' region and addis ababa). the study will enroll approximately 5,100 participants and will be conducted in two survey rounds; one survey round in the belg season and one survey round in the meher season. all participants will have hemoglobin assessed and will have standardized questionnaires administered to assess sociodemographic, diet, morbidity, and other health/nutrition factors. all participants will also have assessments of anthropometric measures, malaria, and soil transmitted helminth infection. a subset of participants will also have serum ferritin, crp, agp, vitamin b12, and folate concentrations assessed. the study data will be used to determine the relative contributions of risk factors for anemia.

Eligibility criteria:
inclusion criteria: 1. women of reproductive age * female living in a selected household that has a woman 15-49 years of age * aged 15-49 years 2. adult men * male living in a selected household that has a woman 15-49 years of age * aged 15-49 years 3. children * male or female child living in a selected household that has a woman 15-49 years of age * aged 6-59 months exclusion criteria: * does not provide informed consent
manual ventilation efficacy with mvg device

Conditions: Ventilator Lung

Summary: the purpose of this research is to investigate the efficacy of the newly designed ventilation grip device (mvg device).


Eligibility criteria:
inclusion criteria: 1. current medical students, post graduate year 1 (pgy1) residents or residents from other specialties with no prior experience in hand mask ventilation techniques or anesthesiology residents and attendings with at least 2 or more years of clinical experience exclusion criteria: 1. refusal to participate in the study. 2. medical students with prior experience in hand mask ventilation techniques (i.e. experiences in previous careers such as nursing or emergency medical technician (emt) professions) 3. any physical inability to adequately perform ventilation

Keywords: manual ventilation grip device
ergonomic considerations on musculoskeletal disorders and posture in software developers.

Conditions: Musculoskeletal Disorders

Summary: the human and computer interface is becoming increasingly intuitive, but for the inexperienced user still poses formidable problems. musculoskeletal symptoms of vdu users are believed to have a multifactorial aetiology. software developers don't have knowledge of ergonomic principles. faulty postures had an effect on posture.

data will be collected from software developer companies in lahore at questionnaire include demographic data and data collection tools. the software developer will be guided about basic ergonomic principles and data will be collected at the start of the study and in 2 stages with a 2-week interval. a quasi-experiment study will be used. the sample size will be323 (margin of error 5%, confidence level 95%, population size 2000, and dist. 50%) by rao software. a convenient sampling technique will be used. data will be analyzed using spss 21 by comparing mean and correlating variables

Eligibility criteria:
inclusion criteria: * software engineers who have experience of more than 2 years, in the same company. * software engineers with the age less than 40 years and both gender. exclusion criteria: * software engineers who had a past history of spine surgery or diseases in the spine like disc prolapse, discitis, arthritis etc. * orthopedically physically challenged * pregnant women.
computer tomography (ct) trial of acute abdomen

Conditions: Acute Abdomen

Summary: the purpose of this study is to determine the impact of routinely performed early ct scanning in terms of diagnostic accuracy, patient management and cost-effectiveness compared to current imaging practice in patients suffering from acute abdomen.


Eligibility criteria:
inclusion criteria: * age \> 18 * abdominal pain \> 2h and \< 7 days exclusion criteria: * pregnancy * acute abdominal trauma * allergy to iodinated contrast media * severe renal insufficiency * metformin medication combined with elevated plasma creatinin level * lack of cooperation (if informed consent is not possible) * abdominal pain combined with bleeding shock
the impact of abdominal wall reconstruction on abdominal wall tension and intra-abdominal pressure

Conditions: Ventral Hernia; Incisional Hernia; Parastomal Hernia

Summary: this is a prospective cohort study. patients have an incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging who will undergo an anticipated open bilateral transversus abdominis release with retromuscular synthetic mesh will have their abdominal wall tension measured using a tension scale and their intra-abdominal pressure measured using a urinary catheter containing pressure sensors. the investigators aim to quantify the changes, as well as explore and describe the physiologic shifts that may be associated with these changes.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age * incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging * anticipated open bilateral transversus abdominis release with retro-muscular synthetic mesh placement exclusion criteria: * pregnant patients * require a legally authorized representative (lar) to sign the informed consent form
utilization and compliance of respiratory syncytial virus monoclonal antibody therapy

Conditions: Lower Respiratory Tract Infection; Respiratory Syncytial Virus Infections

Summary: the purpose of this study is to determine the utilization patterns and compliance rates of palivizumab, which is a monoclonal antibody therapy used to prevent respiratory syncytial virus infection.

respiratory syncytial virus (rsv) is the most important viral respiratory pathogen in children. infection due to rsv represents a large public health burden; in canada, it accounts for 5,800 hospitalizations annually. the peak incidence of rsv disease occurs between 2-6 months of age with half of all infants infected in the first year of life. palivizumab has been approved for the prevention of serious lower respiratory tract disease caused by rsv in pediatric patients at high-risk of rsv disease. these children include those born premature, those with bronchopulmonary dysplasia (bpd), and those with hemodynamically significant congenital heart disease (chd). with the recent approval of palivizumab in canada, access to this medication has increased. however, there are limited data on utilization, compliance, and health outcomes, particularly the frequency and severity of rsv infections. the primary objective of this study is to provide insight into the current management (utilization, compliance) of children at high-risk of rsv infection with palivizumab prophylaxis in the tertiary care centers and community settings through the development of a canadian registry database.

Eligibility criteria:
inclusion criteria: * all children who receive at least one dose of palivizumab exclusion criteria: * the child's parent or legal guardian could not communicate in either english or french * the child had received palivizumab as part of a clinical trial during the study period

Keywords: lower respiratory tract infection respiratory syncytial virus infections palivizumab outcomes utilization compliance
impact of fever prevention in brain injured patients

Conditions: Fever; Ischemic Stroke; Intracerebral Hemorrhage; Subarachnoid Hemorrhage

Summary: this study will assess the impact of fever prevention on fever burden and short- and long-term neurologic outcomes in brain injured patients. half of the subjects will undergo fever prevention using a targeted temperature management system and half of the subjects will be treated for fever should it develop.

multiple studies demonstrate that fever / elevated temperature is associated with poor outcomes in brain injured patients; however, there are no conclusive studies that demonstrate that fever prevention/controlled normothermia is associated with better outcomes. this study will be conducted to assess the impact of advanced temperature control to prevent fever in brain injured patients. the fever prevention group will use the arctic sun temperature management system and will be compared to standard care patients in whom fever may spontaneously develop. if fever develops in a patient in the standard care group, they will be treated with standard fever care measures according to a step-wise algorithm, consisting primarily of intermittent antipyretics (e.g., acetaminophen) and cooling blankets and, when necessary, advanced targeted temperature management devices.

Eligibility criteria:
inclusion criteria: 1. admitted with a primary neurological diagnosis of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage 2. prior to onset of acute symptoms, was considered functionally independent (mrs 0-2) 3. meets disease-specific criteria exclusion criteria: 1. fever (≥38°c) prior to study enrollment 2. pre-existing neurological, psychiatric, or other condition that would confound neurological assessment or would make it difficult to accurately assess neurologic and/or functional outcome 3. has a pre-morbid condition with poor likelihood of survival to 6 months 4. has a pre-morbid mrs ≥3 5. diagnosed with brain death 6. is undergoing therapeutic hypothermia therapy 7. has sustained neurological injury felt to be catastrophic with little chance of recovery 8. has a skin condition in which the use of the arcticgel pads is contraindicated (i.e., skin that has signs of ulceration, burns, hives, or rash) 9. has poor skin integrity or poor tissue perfusion 10. participation in a concurrent investigational / interventional study (medical device or drug)

Keywords: targeted temperature management
adiposity and endothelin receptor function

Conditions: Hypertension

Summary: elevated levels of et-1 have been implicated in cardiovascular disease and some forms of hypertension. due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of adiposity in etb receptor function and aim to elucidate if etb receptor dysfunction is a major contributor to hypertension in obesity.

the proposed study is designed to investigate the influence of adiposity on etb receptor function and subsequent vascular responses. the combination of et-1, et-3, and the respective eta and etb receptor antagonists will be used to provide insight into the mechanisms of etb receptor dysfunction in the presence of adiposity. previous studies have revealed elevations in circulating et-1 in obese individuals; therefore, we predict that obese subjects will exhibit 1) etb receptor dysfuncton compared to lean subjects and 2) an improvement in etb receptor dysfunction following treatment with candesartan.

Eligibility criteria:
inclusion criteria: • if you are an adult between the ages of 18-40 year old exclusion criteria: * evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease * evidence of pregnancy * using medications that affect vascular tone (i.e., nitrates, etc.) * use of any anticoagulants (i.e. aspirin) * anemia * if you are postmenopausal * if you have uncontrolled hypertension (treated resting sbp \>140 mm hg or dbp \>90 mm hg)

Keywords: blood pressure microdialysis
sophrology treatment for patients with glial tumours requiring speech therapy

Conditions: Glial Tumor

Summary: patients with brain tumours experience a loss of independence, which may occur suddenly or gradually. communication with the patient may be rapidly impaired, due to impaired alertness, language and/or neurocognitive disorders. in addition to these clinical symptoms, there is a high level of anxiety and depression in this population due to the severity of the diagnosis, with a major impact on the patients' quality of life. in this study, we are mainly interested in the proportion of this population with communication disorders where speech therapy is important in order to better take into account anxiety, which is often difficult to verbalise due to communication problems, sophrology can be proposed as an alternative to psychological support, which is often too complicated or inappropriate. after having noted positive feedback from patients after joint speech therapy and sophrology treatment, we wish to evaluate the interest of coupling sophrology treatment for patients with glial tumours requiring speech therapy. our hypothesis is that this association would improve the level of anxiety, the quality of life and have a positive impact on the patient's speech therapy.


Eligibility criteria:
inclusion criteria: * patients with histologically proven grade iii and iv glial tumours requiring speech therapy; * patient willing to start outpatient speech therapy; * patient aged 18 years and over; * informed patient who has signed consent; * patient affiliated to a social security scheme. exclusion criteria: * patient who has already had an initiation to sophrology in the context of his pathology; * ps ≥ 4 ; * patients suffering from psychiatric disorders; delusional phases, schizophrenia against the practice of sophrology; * patient unable to follow the protocol (filling in questionnaires, attendance of sophrology and/or speech therapy sessions) for geographical, social or psychological reasons; * patients who do not speak french; * persons deprived of their liberty, under court protection, under curators or under the authority of a guardian. * women who are pregnant, likely to be pregnant or breastfeeding;

Keywords: sophrology speech therapy
polymorphisms in enam, ambn, and klk4 contribute to dcs.

Conditions: Dental Caries Secondary to Polymorphisms; Polymorphisms in Enamel Encoding Genes

Summary: a cross-sectional study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries, particularly within the context of the egyptian population, providing valuable insights into the genetic aspects of oral health. the research methodology involved a comprehensive examination of these polymorphic loci enam, ambn, tuft1 and klk4 and their prevalence, employing rigorous statistical analyses to establish potential correlations between these genetic variants and susceptibility to dental caries.

the research investigates the distributional discrepancies of specific polymorphic loci enam rs3796703, ambn rs4694075, tuft1 rs13236243, and klk4 rs2242670-within the egyptian population as correlatives and causatives of dental caries susceptibility through the genotyping of enamelin (enam rs3796703), ameloblastin (ambn rs4694075), tuftelin 1 (tuft1 rs78802584), and kallikrein 4 (klk4 rs2242670) in 132 adults (males = 74, females = 58) and 72 controls (males = 40, females = 32) referred from various egyptian hospitals. for each participant, the number of decayed, missing, and filled teeth was charted, and the presence of biofilm/gingivitis/fluorosis was assessed. bitewing radiographs were taken to detect interproximal caries. in addition, statistical analysis was conducted using chi-square test, odds ratios, and corresponding p-values.

Eligibility criteria:
inclusion criteria: * presence of dental caries or decay in form of discoloration, cavities, or visible enamel softening suggestive of potential caries (caries-susceptible group) * caries-free patients as control group (caries-resistant group) exclusion criteria: * the presence of white spots or fluorosis, indicating enamel defects or demineralization, required exclusion from the study.

Keywords: enamelin (enam) ameloblastin (ambn) tuftelin 1 (tuft1) kallikrein-related peptidase-4 (klk4) dental caries polymorphisms
effect of acute supplementation (taurine) on maximal strength and anaerobic power

Conditions: Taurine

Summary: this crossover-design study examines the acute effect of taurine on trained individuals aged 18-40 on strength and power outputs.

the purpose of this study is to further investigate any potential ergogenic effects offered by taurine, under specific conditions, namely that of acute supplementation, as opposed to the chronic supplementation protocols of many popular ergogenic aids, such as creatine and beta alanine. exercise modes investigated include maximal isometric strength, maximal instantaneous power generation, and sustained maximal anaerobic power output, investigated via grip strength, vertical jump height, and the wingate test, respectively.

Eligibility criteria:
inclusion criteria: * participants 18 - 40 years of age * physically active or recreationally active with consistent training more than 3 times per week for at least 6 months * non-smokers exclusion criteria: * cardiovascular, respiratory or metabolic diseases * any musculoskeletal injury in the last six months * taking taurine and/or creatine supplementation in the past three months

Keywords: taurine power strenght exercise
protective effect of angong niuhuang against negative inflammatory response and neurologic dysfunction after cardiovascular surgery

Conditions: Cardio-pulmonary Bypass; Cardiovascular Surgery; Cerebral Protection; Brain Injury

Summary: neurologic dysfunction is one of the main factors contributing to poor outcomes in cardiac surgery patients, except for heart failure. atherosclerosis of the aorta, a history of cerebral infarction, and cervical artery disease are common clinical risk factors for cerebral neurological dysfunction after cardiac surgery. results of preclinical studies suggested that angong niuhuang pills (anps), a traditional chinese patent medicine, including realgar, cinnabaris, bovis calculus, artificial moschus, and powdered buffalo horn extract, decreased infarct volume and cerebral edema, and presented anti- atherosclerosis and cardio-protective effects in clinical and preclinical studies. the panda x trial is designed as a pilot study to explore the safety and efficacy of anp in patients with moderate-to-severe neurologic dysfunction after cardiovascular surgery.


Eligibility criteria:
inclusion criteria: * (1) an age \> 18 years, * (2) underwent cardiovascular surgery, * (3) diagnosis of acute neurologic dysfunction, including but not limited acute cerebral infarction of the internal carotid artery system, * (4) a national institutes of health stroke scale (nihss) score ranging from 10 to 20, * (5) a time from symptom onset to randomization within 36 h, * (6) provision of informed consent. exclusion criteria: * (1) not suitable for taking anp after the dialectical process by a traditional chinese medical doctor, * (2) received anp within 1 month before stroke onset, * (3) liver failure, * (4) declined to participate in this study.

Keywords: inflammatory response cardiopulmonary bypass
the turkish oropharyngeal dysphagia screening test for patients and professionals

Conditions: Swallowing Disorder

Summary: the purpose of this study is to test the reliability and validity of the the turkish oropharyngeal dysphagia screening test for patients and professionals among adult patients with swallowing disorders.

the purpose of this study is to test the reliability and validity of the the turkish oropharyngeal dysphagia screening test for patients and professionals among adult patients with swallowing disorders.the internal consistency, test-retest reliability, and criterion validity of the instrument will be investigated. the internal consistency will be assessed using cronbach's alpha. intraclass correlation coefficient (icc) value with 95 % confidence intervals will be calculated for test-retest reliability. the criterion validity of the scale will be determined by assessing the correlation between the the turkish oropharyngeal dysphagia screening test for patients and professionals and turkish eating assessment tool.

Eligibility criteria:
inclusion criteria: * willing to participate * having swallowing problems exclusion criteria: * being under the age of 20 years, and above the age of 60 years * not willing to participate * no swallowing problems