Kornimate/medical-research-clean huggingface dataset:
ultrasound imaging of subarachnoidal space in newborn infants

Conditions: Ultrasound; Newborn Infant

Summary: based on the ultrasound measurement of csf/spinal cord ratio in neonates the investigators plan to define a normal range of csf volume for 0-7 day old newborns. the investigators hypothise to be able to create an ultrasound measurement index/number to predict unsuccessful neonatalal lps.

based on the available literature the success rate of neonatal lumbar puncture (lp) is quite low (some articles reporting as low as 50% (unsuccessful lps including dry taps and traumatic taps)). firstly, the investigators would like to set a normal range of csf:spine ratio (representing the amount of csf at the expected level of lp) based on the measurements in neonates of different gestational age and postnatal age with assessing ventricular index (vi) on cranial us. in the next phase of the study the investigators plan to assess the subarachnoidal space/amount of csf of those neonates whom need lp performed. the investigators hypothise to be able to create an ultrasound measurement index/number that would be able to predict unsuccessful lps.

Eligibility criteria:
inclusion criteria: all neonates born at the obstretrics and gynecology department, university of szeged and all treated neonates at the neonatal unit, pediatric department, university of szeged exclusion criteria: hemidynamical instability, strict minimal handling (eg pulmonary hypertension, mas etc), total body coooling for hie (hypoxic ischemic encephalopathy)
long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation or spinal stenosis

Conditions: Lumbar Disc Herniation; Lumbar Spinal Stenosis

Summary: the rate of success 12 months after surgery is reported to be 60-65% in patients with lumbar disc herniation and 60-70% in patients with spinal stenosis. at the back center copenhagen, patients with persistent low back pain caused by lumbar disc herniation and spinal stenosis are treated by a multidisciplinary team comprising rheumatologists, physiotherapists, chiropractors, and social workers according to current guidelines. therefore we have a unique opportunity to report the long term outcome in candidates for surgery, regardless of whether they have surgery or not, after having received optimal but unsuccessful nonsurgical treatment. the purpose of this study is to answer the following questions: 1) what is the proportion of patients operated upon after referral to surgical evaluation with positive mri findings, persistent low back pain, and poor outcome following non-operative treatment? 2) what was the outcome in these patients 2 years following referral? 3) where any baseline variables predictive of good or poor postsurgical outcome? 4) where there any difference in outcome in patients with or without surgery?


Eligibility criteria:
inclusion criteria: * duration of symptoms more than 3 months * positive imaging findings * non-surgical treatment unsuccessful exclusion criteria: * age below 18 or above 65 years * lumbar fusion * psychiatric disorders * other serious diseases * unable to understand the danish language
early strength training after hip fracture surgery

Conditions: Hip Fractures

Summary: patients treated surgically for a hip fracture have a need of rehabilitation for the regain of former functional skills. despite an optimized fast track in-hospital rehabilitation program it has been found that patients with hip fracture within 2 weeks after the hip fracture loose more than half of their muscle strength in the fractured limb compared to non-fractured limb. new studies including patients with total hip arthroplasty and strength training applied early after surgery has shown promising results regarding prevention of loss of muscle strength. no similar study has been found including patients with hip fracture. the purpose of this study is to examine the feasibility of progressive knee-extension strength training of the hip fractured limb, starting day 1 after surgical treatment for a hip fracture and proceeded every weekday during their hospital stay. the study will include 20 patients surgically treated for a cervical hip fracture and 20 patients surgically treated for an intertrochanteric or subtrochanteric fracture. all patients are admitted from their own home. age 60 years or older.

kronborg l, bandholm t, palm h, kehlet h, kristensen mt (2014) feasibility of progressive strength training implemented in the acute ward after hip fracture surgery. plos one 9(4): e93332. doi:10.1371/journal.pone.0093332

Eligibility criteria:
inclusion criteria: * hip fracture diagnosed patients age ≥60 years, admitted to the acute hip fracture unit. * medial femoral neck fracture, pertrochanteric fracture or subtrochanteric fracture. * ability to speak and understand the danish language. * cognitively well-preserved and able to give personal informed consent no later than by 5th post surgical day. * home-residing and with an independent pre-fracture ability to walk equal to new mobility score at ≥ 2 indoor. exclusion criteria: * multiple fractures * postsurgical restrictions of mobilization * patient not accepting participation in relevant exercise therapy * fracture caused by cancer metastases * terminal illness * neurological impairment e.g. hemi paresis.

Keywords: hip fractures strength training
evaluation of patients with covid-19 infection in terms of severity of osteoprosis

Conditions: Severity of Osteoprosis

Summary: osteoporosis is a condition characterized by decreased bone strength and an increased risk of fracture. age, gender, body mass index, fragility fracture history, corticosteroid use, immobilization, smoking and alcohol use, endocrine pathologies besides inflammatory and infectious pathologies can also be effective in the development of osteoporosis. the aim of the study is to evaluate the effect of covid-19 infection on the development of osteoporosis. in this study, bone mineral density (bmd) measurements of patients with covid-19 infection were examined. for this, dual-energy x-ray absorptiometry (dexa) measurement was used. a total of 55 patients were included in the study and data such as age, height, weight, comorbidities, drugs used, and treatment methods were recorded. results showed that the time spent in the intensive care unit was associated with the femoral neck t score in dexa measurements of patients with covid-19 infection. the use of drugs such as alendronate, zolendronate, denosumab or teriparatide during the treatment process did not have a statistically significant effect on the lumbar and femur t scores.


Eligibility criteria:
inclusion criteria: * female patients over the age of 18 who had dexa measurements twice before and after covid, with at least one year between two dexa measurements, and at least one month after covid infection were included in the study. exclusion criteria: * under the age of 18, male patients, patients with a diagnosis other than covid-19 infection that will affect bone metabolism between the two dexa shooting dates before and after covid, patients who use another drug other than covid treatment that will affect bone metabolism between the two dexa shooting dates before and after covid not included in the study
a study to determine the bioequivalence of sch 900068 compared to marketed products (protocol no. p07551)

Conditions: Hyperlipidemia

Summary: the intent of this study is to demonstrate that single doses of the final market image (fmi) ezetimibe/atorvastatin 10mg/10mg and 10mg/80mg fixed dose combination (fdc) tablets are bioequivalent to the same doses of ezetimibe (zetia®) and atorvastatin (lipitor®) that are coadministered as individual tablets in healthy adults.


Eligibility criteria:
inclusion criteria * healthy adult males and females age 18-55 years * body mass index (bmi) between 18-35 kg/m\^2 * clinical laboratory tests (complete blood count, blood chemistry, and urinalysis), electrocardiogram, and vital signs must be within normal limits * must agree to refrain from consumption of red wine, grapefruit, and grapefruit-containing products, orange and apple juices, and orange- and apple-containing products from beginning approximately 2 weeks prior to administration of the initial dose of study drug, throughout the study (including the washout interval between treatment periods), and until the poststudy visit exclusion criteria * female subjects who are pregnant, intend to become pregnant (within 3 months of ending the study), or are nursing/breastfeeding. * any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of any drug * history of any infectious disease within 4 weeks prior to drug administration * have demonstrated allergic reactions or hypersensitivities or intolerance to atorvastatin or other 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) reductase inhibitors, ezetimibe, or any component/excipient of the study drug or other food, drug, atopic reactions or asthmatic episodes which, in the opinion of the investigator and sponsor, interfere with their ability to participate in the trial. * have a history of prior myopathy or abnormality in liver function studies with statin therapy. * are positive for hepatitis b surface antigen, hepatitis c antibodies, or hiv. * have donated blood in the past 60 days * consume excessive amounts, defined as greater than 6 servings (1 serving is approximately equivalent to 120 mg of caffeine) of coffee, tea, cola, or other caffeinated beverages per day.

Keywords: hyperlipidemia statin ezetimibe zetia atorvastatin lipitor
the analysis for termination of treatment and satisfaction in traffic accident patient

Conditions: Accidents, Traffic; Whiplash Injuries

Summary: data of one hospital will be used to find out the patient's satisfaction with the treatment, analyze the factors effecting on the treatment termination. also, plan to see if there is a correlation between prognosis according to the seriousness of the accident. in addition, investigators want to find out the participants' perception of car insurance and their satisfaction with traditional korean medicine treatment.

retrospective data will be extracted using electronic medical records and computerized data of hospitalized patients. based on this, investigators will conduct research in the form of prospective survey and analyze the causal relationship and factors using the two data. the hospital's medical records will be used to analyze the patient's condition during the hospitalization period and to determine the situation after the end of treatment through questionnaire. the questionnaire will be developed after consultation with experts from musculoskeletal system and related societies, and will be used for the questionnaire.

Eligibility criteria:
inclusion criteria: * age 19 to 65 * a traffic accident injury patient who had been hospitalized at haeundae jaseng korean medicine hospital from jan. 01, 2016 to dec. 31, 2018. exclusion criteria: * people whose traffic accidents are not yet agreed to * those who have not exceeded 90 days (3 months) since the conclusion of the agreement * persons unable to communicate

Keywords: traffic accident traditional korean medicine car insurance whiplash injury
randomized study of photodynamic therapy using dihematoporphyrin in patients with corneal neovascularization

Conditions: Corneal Neovascularization

Summary: objectives: i. demonstrate the safety and efficacy of dihematoporphyrin derivative (dhp) in laser photodynamic therapy (pdt) in patients with corneal neovascularization. ii. document the histopathologic mechanism of action in selected patients undergoing penetrating keratoplasty following pdt therapy for corneal neovascularization. iii. facilitate fda product approval of dhp as a photosensitizing agent for laser treatment in these patients. iv. explore the use of this photosensitizer for ocular and cutaneous basal cell and squamous cell carcinoma.

protocol outline: this is a randomized, placebo controlled study. patients are randomized to 1 of 3 treatment arms: arm i: patients receive topical dihematoporphyrin derivative (dhp) every 3 hours on days -3 and -2. patients undergo laser surgery on day 0. after photodynamic (pdt) therapy, patients receive topical prednisolone phosphate four times a day for 90 days. ninety days following pdt, patients may undergo corneal transplantation. arm ii: patients receive placebo topical gel and undergo sham laser surgery following arm i schedule, then receive topical prednisolone phosphate four times a day for 90 days. patients may be crossed over to arm i if disease progression is observed. arm iii: patients receive a compressed 1 day schedule of dhp with 5 doses in the morning and then undergo laser surgery in the evening. patients are assessed on days 1, 7, 30, and 90 after pdt therapy. completion date provided represents the completion date of the grant per oopd records

Eligibility criteria:
* histologically proven corneal neovascularization (cnv): must have at least 1 quadrant of significant cnv, which is due to bacterial, viral, parasitic, or fungal keratitis; alkaline acid or hydrocarbon chemical burns; ocular trauma and injury; severe ocular surface disease; or previous surgery with complications such as corneal allograft rejection are eligible * no concurrent systemic steroids * no concurrent immunosuppressive therapy * not pregnant or nursing; negative pregnancy test; fertile patients must use effective contraception; hiv negative; no rheumatoid arthritis; no congenital corneal scars; no active ocular infection or inflammation; no other active systemic collagen vascular disease; no uncontrolled glaucoma; no history of porphyrin allergies; visual acuity of 20/400 or better in contralateral eye

Keywords: cardiovascular and respiratory diseases corneal neovascularization rare disease
comparison of hemostatic matrix and bipolar coagulation in surgical treatment of endometriomas

Conditions: Ovarian Reserve; Endometrioma

Summary: in this study, impacts of hemostatic matrix and bipolar electrocoagulation on ovarian reserve in women undergoing ovarian endometrioma excision are compared.

endometriosis is defined as the existence of endometrial tissue outside of the uterine cavity. ovaries are the most common effected sites and the disease causes endometriotic cysts in the ovaries. the treatment of endometriomas is still highly controversial. it is well known that the ovarian reserve is compromised as a result of endometriomas. even though a variety of medical agents can be used to treat endometriomas, when endometriomas cause pelvic pain or infertility especially when they are \> 4cm in size, surgical treatment can be offered. even though there is no standard surgical treatment removal of cyst wall is usually the preferred method. aspiration of cyst fluid and coagulation of the cyst wall have been practiced, however are associated with more recurrences. nevertheless, the impact of surgical treatment on ovarian reserve has not been clarified. there are mainly two types of ovarian injury during surgical removal of endometriomas. first, there is risk that the healthy ovarian tissue can be removed along with the cyst wall. second, there is risk of of thermal injury that occurs after cyst removal during hemostasis by electrocoagulation. by this context, investigating an alternative method to electrocautery which causes less thermal injury to ovary would open a new strategy in the treatment of infertile patients with endometrioma. a new method "hemostatic matrix" has been developed to provide hemostasis. endometriomas can be treated without thermal injury to healthy ovarian tissue using this method compared to bipolar coagulation. in the literature, there is no controlled randomized study compared hemostatic matrix and bipolar coagulation for impact on ovarian reserve after treatment ovarian endometriomas. there are two main principles when treating endometriomas. first, recurrence should not occur, and the second is minimal ovarian injury. on the backgrounds of this philosophy, it can be hypothesized that hemostatic matrix can cause less damage to ovarian tissue compared to classical bipolar coagulation.

Eligibility criteria:
inclusion criteria: * patients in reproductive ages * presence of ovarian endometrioma at least 4 centimeter in size exclusion criteria: * previous ovarian surgery * pregnancy * lactation * diabetes mellitus, thyroid or adrenal disorders, hyperprolactinemia * history or suspicion of malignancy * use of oral contraceptive drug, gnrh agonist or antagonist, danazol and other drug relation with ovarian function in last 6 months

Keywords: ovarian reserve endometrioma excision hemostatic matrix bipolar electrocoagulation thermal injury
comparing the effects of holmich protocol exercise therapy and joint mobilization training on pain, balance, function of the lower limb, and muscle activity in soccer players with athletic groin pain.

Conditions: Groin Pain

Summary: the goal of this clinical trial is comparison the holmich protocol exercise therapy and joint mobilization training, investigating their respective effects on muscle activity in soccer players with athletic groin pain. the main questions it aims to answer are: is there a difference between holmich protocol exercise therapy and joint mobilization training on pain, balance, function of the lower limb, and muscle activity in soccer players with athletic groin pain ? researchers will compare holmich protocol exercise therapy (ht)with joint mobilization training (jmt) to see if the exercises are effective on pain, balance, lower limb function, and muscle activity. participants will: practice holmich protocol exercise therapy (ht) three times a week, 90 minutes per session, for 12 weeks. practice joint mobilization training (jmt) for 12 weeks.


Eligibility criteria:
inclusion criteria: 1. male 2. between 18-35 years old 3. have a normal body mass index (bmi) 4. desire to return to the former level of sports activity 5. groin pain for at least 2 months 6. pain at palpation of the adductor tendons or the insertion of the pubic bone or both; groin pain during active adduction against resistance (squeeze test); pain during adduction against resistance had to be less than six\*, based on the visual analogue scale (vas). 7. in addition, at least two of the following criteria had to be present: a clear history of groin pain and stiffness in the morning, cough induced or sneeze-induced groin pain, nocturnal groin pain or radiological evidence demonstrating osteitis pubis or pain at the symphysis pubis due to palpation. exclusion criteria: 1. receiving physical therapy or other conventional therapy in the past 6 months. 2. absence in one of the pre- or post-test sessions. 3. absence of more than two sessions in practice sessions.

Keywords: holmich protocol groin pain joint mobilization training electromyography pain
animal-assisted interventions in health promotion for elderly with dementia

Conditions: Dementia

Summary: the overall research aim of this study is to investigate changes in measures related to the risk of falls among elderly with dementia participating in animal-assisted interventions. also relatives' experience of own and the elderly's situation during and after the intervention will be examined. the design will be a prospective and cluster randomized multicenter trial, but mixed-methods will be used to target different outcomes. the study population will be elderly (age above 65) at day care centers diagnosed with dementia, or having a cognitive deficit. the intervention will consist of 30 minutes sessions with animal-assisted activity or animal-assisted therapy two times a week for 12 weeks in groups of 4-6 participants. control groups will receive treatment as usual. research questions: 1. is there an effect in use of ordinary and optional medication among elderly persons with dementia at day care centers participating in animal-assisted interventions compared to a control group? 2. is there an effect on social interaction, quality of life, activeness and wellbeing among elderly persons with dementia at day care centers participating in animal-assisted interventions compared to a control group? 3. is there an effect on balance among elderly persons with dementia at day care centers participating in animal-assisted therapy compared to animal-assisted activity or a control group? 4. do relatives of elderly persons with dementia at day care centers experience a change in their own and the elderly's situation after the intervention compared with before the intervention started?


Eligibility criteria:
inclusion criteria: * diagnosis of dementia or having a cognitive deficit measured as a score less than 25 on mini-mental state examination. exclusion criteria: * fear of dogs, dog allergy or need of wheel chair
maintaining patency in bioflo implanted port catheters with saline only flushes

Conditions: Obstruction; Catheter, Infusion Catheter (Vascular); Catheter; Complications (Indwelling Catheter)

Summary: the purpose of this study is to determine the safest and most effective flushing solution for maintaining patency (unobstructed flow) in bioflo implanted port catheters. the complication rate in patients whose ports are flushed with saline only will be compared to the complication rate in patients whose ports are flushed with a combination of saline and heparinized saline.

the purpose of this study is to determine the safest and most effective flushing solution for maintaining patency (unobstructed flow) in bioflo implanted port catheters. the complication rate in patients whose ports are flushed with saline only will be compared to the complication rate in patients whose ports are flushed with a combination of saline and heparinized saline. these complications include partial or complete obstruction, infection of the central line, and/or the onset of heparin induced thrombocytopenia.

Eligibility criteria:
inclusion criteria: * able to read and understand english * has a bioflo implanted port in place less than one (1) year * evidence of a patent bioflo port catheter prior to enrollment in the study * is receiving active treatment (i.e., receiving a therapeutic drug) through the bioflo implanted port * current treatment protocol projected to continue for a minimum of three (3) months * anticipates receiving care at the identified centers for 12 months following enrollment in the study * does not receive care of bioflo implanted port at any other facility exclusion criteria: * has documented heparin platelet antibody (i.e., could not be randomized to either group) or other allergy to heparin * receiving therapeutic dose of an anticoagulant (e.g.,warfarin, heparin, enoxaparin) * does not meet one or more of the inclusion criteria