Kornimate/medical-research-clean huggingface dataset:
effect of caffeine supplementation and personalized insoles on females

Conditions: Caffeine; Fatigue; Injuries; Females Xy; Soccer; Biomechanical Parameters

Summary: several studies have shown the positive effect that caffeine has on athletic performance related variables. nonetheless, most studies have been developed in males and have not studied the possible effects on biomechanics and related injuries. moreover, the inclusion of personalized insoles could also affect biomechanical patterns and thus injury incidence that has shown to be higher when athletes are fatigued. therefore, the aim of the present randomized controlled trial is to evaluate the effect of fatigue, caffeine supplementation and personalized insoles on biomechanics and athletic performance in female adult soccer players.


Eligibility criteria:
inclusion criteria: * females * soccer players who have been competing for at least 3 years exclusion criteria: * participants with major injuries in the lower limbs within the 12 months before testing. * participants consuming ephedrine or related medicines

Keywords: women insoles kinematics kinetics performance athletics team sport
determination of rates and reasons for non-adherence to anti-arrhythmic therapy for atrial fibrillation

Conditions: Atrial Fibrillation; Medication Adherence

Summary: the purpose of this study is to determine if follow-up by a pharmacist over the telephone improves adherence and short term clinical outcomes in the patient with atrial fibrillation prescribed an oral anti-arrhythmic medication. this study will also identify the reasons people stop taking their anti-arrhythmic therapy. a pharmacist will provide medication counseling about their anti-arrhythmic therapy, then will follow-up by telephone on a monthly basis to assess adherence over one year.


Eligibility criteria:
inclusion criteria: * prescribed a new anti-arrhythmic medication for atrial fibrillation

Keywords: atrial fibrillation anti-arrhythmic medication medication adherence
efficacy and safety of valsartan and the combination of valsartan and simvastatin

Conditions: Hypertension; Hypercholesterolemia; Dyslipidemia

Summary: this study will assess and compare the efficacy and safety of valsartan and the combination of valsartan and simvastatin in patients with high blood pressure and high cholesterol.


Eligibility criteria:
inclusion criteria: * male or female patients at least 50 years of age * mild to moderate essential systolic hypertension (grades 1 and 2 who classification) defined as mssbp ≥ 150 mmhg and \<180mmhg * simultaneous primary hypercholesterolemia or mixed dislipidemia (fredrickson types iia and iib) defined by ldl-c level ≥ 130 mg/dl and \<190 mg/dl and triglyceride levels ≤ 400 mg/dl despite dietary therapy * off medication at randomization exclusion criteria: * severe hypertension (grade 3 who classification * ≥ 180 mm hg systolic or ≥ 110 mm hg (diastolic) * secondary form of hypertension * known keith-wagener grade iii or iv hypertensive retinopathy * history of hypertensive encephalopathy or cerebrovascular accident within the preceding 12 months * transient ischemic cerebral attack during the preceding 6 months * dyslipidemia secondary to other causes * type 1 diabetes mellitus * type 2 diabetes mellitus with poor glucose control * history of systemic inflammatory diseases * serum ck more than twice uln * sodium depletion * malignancy in preceding 5 years history of heart failure * myocardial infarction within the preceding 12 months * second or third degree heart block * concomitant refractory angina pectoris * symptomatic arrhythmia * valvular heart disease * any condition/surgery that may alter absorption, distribution, metabolism, excretion of any drug (e.g. history of major gastrointestinal tract surgery, inflammatory bowel syndrome, pancreatic dysfunction, impaired renal or liver function)

Keywords: hypertension high cholesterol valsartan simvastatin
effectiveness of low dose aspirin in decreasing the chance getting stomach and intestine cancer

Conditions: Gastrointestinal Cancer

Summary: in this study, researchers wanted to learn more about the effect of aspirin taken as low dose (75 - 300 mg) in preventing stomach, colorectal and esophagus cancer. the researchers were interested in the effect by duration of aspirin use and the effect on the time since aspirin intake has been stopped in preventing stomach, colorectal and esophagus cancer. in addition, the study also looked into the time patients survived after being diagnosed (survival rate) with cancer and number of cancer patients who died (case fatality rate). the study was based on an electronic database managed by the health authority in hong kong containing anonymized clinical information of patients living in hong kong.


Eligibility criteria:
inclusion criteria: - received prescription of either low-dose aspirin (75-300 mg) or paracetamol monotherapy during enrolment period. exclusion criteria: * received prescription of aspirin monotherapy or combination one year prior to the index date * recorded diagnoses of any type of cancer before the index date * recorded procedures of colectomy, gastrectomy prior to the index date * age \< 40 years

Keywords: esophageal cancer gastric cancer colorectal cancer
is orthostatic hypotension associated with nondipping hypertension

Conditions: Orthostatic Hypotension; Nondipping Hypertension

Summary: the aim of the study is to evaluate whether orthostatic hypotension is associated with nondipping hypertension. methods and patients: 400 subjects who are referred for 24habpm will be filled questioner regarding their medical background and medications. all patients will be subjected to orthostatic test before connection to the 24 abpm. the orthostatic changes in blood pressure and heart rate will be correlated to the changes in blood pressure and heart rate from day to night as recorded by the 24h abpm.


Eligibility criteria:
inclusion criteria: * all patients who are referred for abpm exclusion criteria: * known secondary hypertension

Keywords: orthostatic hypotension ambulatory blood pressure monitoring
predictors of osa in patients with copd

Conditions: OSA; COPD

Summary: chronic obstructive pulmonary disease (copd) and obstructive sleep apnea(osa) are common disorders ,the co-existence of both conditions is called overlap syndrome smoking , obesity , airway resistance and inflammation are considered risk factors for both conditions ,interestingly either copd and osa are associated with increased cardiovascular complications with further increased risk in overlap syndrome multiple theories could explain that one disorder can predispose or exaggerate the other. for example, in copd cigarette smoking and inhaled steroids are linked to myopathy of upper airway dilator muscles. moreover in core-pulmonale redistribution of edema fluid in supine position during sleep can also contribute to or exacerbate osa . on the other hand , osa patients might smoke frequently and more heavily to compensate for excessive daytime sleepiness and to help them to lose weight , which results in exaggerated airway inflammation and exacerbate copd. rationale of the study was to assess the prevalence and predictors of osa among patients with stable copd.


Eligibility criteria:
inclusion criteria: * all stable copd patients exclusion criteria: * patients with end organ failure
hysteroscopic evaluation and the clinical outcomes of vaginal repair of cesarean section scar defects

Conditions: Magnetic Resonance Imaging; Hysteroscopy

Summary: cesarean section scar defects (csds) are one of the long-term complications following cesarean section. they can be detected by transvaginal sonography, hysterosalpingography, sonohysterography and magnetic resonance imaging (mri). hysteroscopy is frequently used in evaluating endometrial disease. however, the description of csds by hysteroscopy is very limited. only a few papers about hysteroscopy evaluation have been published. this is an exploratory study to compare hysteroscopic findings with the clinical outcomes of vaginal repair of csds.

all women with csd suffered from abnormal uterine bleeding and were evaluated in a standardized way with hysteroscopy before vaginal surgery. dome-shaped csds could be clearly observed in all patients under hysteroscopy. we recorded the pictures of each patient under hysteroscopy and classified them. they all underwent vaginal excision and suture of csd and will be required to undergo examinations at 3- and 6-months after surgery. preoperative and postoperative clinical information will be collected. all patients obtain menstrual information and csd scar size by mri or transvaginal sonography.

Eligibility criteria:
inclusion criteria: * the inclusion criteria are non-pregnant patients who had one or more cesarean sections, patients who had intermenstrual spotting after the cesarean section or those in which the trm was less than 3.0 mm at the preoperative stage, and patients who underwent mri and tvs to evaluate the size of the defect and the trm before surgery exclusion criteria: * patients who had a history of chronic diseases (such as cerebro-cardiovascular diseases, malignancies and diabetes mellitus), endocrine disorders, menstrual irregularities before cesarean section, coagulation disorders, use of intrauterine devices, sub-mucous myoma, endometrial diseases, endometrial cysts, uterine fibroids, and adenomyosis after cesarean section

Keywords: cesarean section scar defect hysteroscopy surgical outcomes
perceptual learning treatment for amblyopia

Conditions: Amblyopia

Summary: objectives. to develop a new treatment for amblyopia using a perceptual learning approach. hypothesis to be tested. our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia. design and subjects. a total of 36 patients with amblyopia will be randomized allocated into two intervention groups: group 1, perceptual learning therapy. group 2, occlusion therapy. a control group comprising of 18 subjects with normal vision will be recruited for comparison. a battery of tests will be used to assess a range of visual functions before and after the treatment intervention. study instruments. grating acuity testing system interventions. we have established a clinical protocol for acuity training. on each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. the visual task is to indicate the location of the stimulus. participants will be required to undertake 20 one-hour sessions of training. main outcome measures. resolution acuity, visual acuity, contrast sensitivity function


Eligibility criteria:
inclusion criteria: * visual acuity in the amblyopic eye: 20/25 or worse exclusion criteria: * manifest eye disease \& nystagmus
low-frequency electrical stimulation of acupuncture points

Conditions: Stroke Sequelae

Summary: abstract: objective: to examine the effect of low-frequency acupoint electrical stimulation (lfes) on the surface electromyographic (semg) signals of the thumb-to-finger movement muscles in stroke patients, and to evaluate the clinical efficacy of lfes on hand function recovery after stroke.

methods: sixty patients who met the inclusion criteria were randomly assigned to a lfes group or an electroacupuncture (ea) group, with 30 patients in each group. both groups received conventional treatment, and the ea group was treated with acupoints from the book of acupuncture and moxibustion, while the lfes group was treated with acupoints from a previous study. the semg characteristic values (max and rms), chinese stroke clinical neurological deficit scale (css), brunnstrom motor function evaluation, modified ashworth scale (mas), lindmark hand function score and lovett muscle strength classification were measured before and after treatment.

Eligibility criteria:
inclusion criteria: ①diagnostic criteria for upper extremity motor dysfunction after stroke. ②age 35-75 years and duration of illness is 2 weeks to 3 months. ③ impaired hand function with lovett classification ≥ grade 2 and mas ≤ grade 2. ④no organ dysfunction such as heart, liver, lung, kidney or blood circulation dysfunction. ⑤clear consciousness, no major impairment in intelligence, hearing or speech, and stable condition. ⑥patients voluntarily participated in this subject trial and signed the informed consent form. exclusion criteria: * presence of neurological or musculoskeletal disorders affecting functional recovery prior to the onset of the disease. ②brainstem infarction, bilateral cerebral infarction or transient ischemic attack.
evaluation of the effectiveness of prophylactic lmwh by thromboelastography

Conditions: Malignancy

Summary: this study aims to evaluate the necessity and effectiveness of using low molecular weight heparin (lmwh) for prophylaxis in the postoperative period in patients who underwent lobectomy due to malignancy, using thromboelastography.blood samples taken from the patients before low molecular weight heparin prophylaxis (preoperative), before prophylaxis in the postoperative period (postoperative day 1) and after the start of postoperative prophylaxis (postoperative day 3) will be examined by thromboelastography.

general characteristics of the patients such as age, gender, presence of comorbidities, smoking, type of operation and approach applied, operation duration, teg measurements and postoperative complication development were recorded with case forms.

Eligibility criteria:
inclusion criteria: * patients who underwent lobectomy with thoracotomy or videothoracoscopy (vats) due to malignancy (primary or secondary lung cancer) exclusion criteria: * patients with a known diagnosis of bleeding or coagulation disorders * patients receiving anticoagulant and antiplatelet therapy in the preoperative period * patients who developed perioperative bleeding and therefore underwent perioperative blood and blood product replacement

Keywords: malignancy lobectomy prophylaxis thromboelastography
partnerships to improve lifestyle interventions (pili) 'ohana dissemination project

Conditions: Obesity

Summary: the purpose of the oha pili 'ohana project is to disseminate and evaluate the effectiveness of a community-based intervention (pili 'ohana intervention program) aimed at eliminating obesity in pacific peoples across the four islands. dissemination will involve implementation of the program in eight communities through partnerships with nine different community-based organizations serving those areas (four founding community partners and five new community partners). these organizations provide services to a large number of pacific peoples, including (but not limited to) native hawaiians, samoans, filipinos, and chuukese. the main aims are to: (1) train five additional community organizations and their staff to deliver the pili 'ohana intervention program, (2) to enroll 150 overweight/obese participants across 8 different communities and four different islands into the intervention program, and (3) to evaluate the effectiveness of the program in reducing weight/bmi by at least 3% of the participant's initial weight. the pili 'ohana intervention is a 9-month lifestyle intervention focusing on individual health behaviors in the context of family and community environments and in the socio-cultural context of pacific peoples. in order to increase the likelihood that an organization will implement the plp, they will be able to adapt the intervention and participant assessments. the pop will provide guidance on adaption of the intervention and assessments at the training (chs #21680). what is described below is the maximum amount of contact and assessment procedures that participants will undergo. therefore, organizations may change the timing of the 14 lessons and refrain from using all the assessment procedures, but will still provide the 14 lessons and offer the same incentives to participants for assessments.


Eligibility criteria:
inclusion criteria: * bmi greater than or equal to 25 * clients and/or residents of communities served by 9 partnering community organizations exclusion criteria: -
adding venetoclax to the high-dose chemotherapy regimen prior to mismatche allogeneic stem cell transplant

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes

Summary: patients eligible for a mismatch allogeneic stem cell transplant will receive venetoclax daily for 7 days prior to transplant in addition to the following chemotherapy regimen: decitabine daily for 5 days, fludarabine daily for 5 days, and busulfan daily for 2 days followed by 1 day of total body irradiation. stem cell transplant will occur thereafter.


Eligibility criteria:
inclusion criteria: * availability of a 4/8 - 6/8 hla-matched related donor or a 7/8 hla-matched unrelated donor * receiving first allogeneic transplant * kps \>/= 70% * mds associated with tp53 mutation and r-ipss high or very high risk at diagnosis or * aml with adverse risk cytogenetics or molecular abnormalities according to the 2017 eln risk stratification or pre-transplant mrd by either flow cytometry, cytogenetics or fish * less than 5% myeloblasts in the marrow pre-transplant exclusion criteria: * poor cardiac function defined as lvef \<45% * poor pulmonary function defined as fev1, fvc, or dlco \<50% predicted * poor liver function defined as bilirubin \>/=2.5mg/dl, ast/alt \>3xuln * poor renal function defined as creatinine \>/=2.0mg/dl or crcl \<40ml/min * ongoing or active systemic infection, active hepatitis b or c virus infection, or known hiv positivity * patient requiring treatment with a moderate or strong inhibitor or inducer of cyp3a4 or a p-gp inhibitor within 7 days prior to starting preparative chemotherapy through day +4 post-transplant
seating posture and its relation to pain

Conditions: Posture; Myositis; Sitting Position

Summary: a study has been designed to evaluate pain levels experienced by subjects in relation to different sitting postures. the objective is to investigate how various ergonomic sitting positions affect pain intensity, by systematically assessing pain across a range of sitting postures to identify significant differences and correlations.

a study has been designed to evaluate the pain levels experienced by subjects in relation to different sitting postures. the primary objective of this research is to investigate how various ergonomic sitting positions impact the intensity of pain reported by individuals. this will involve systematically assessing pain levels across a range of sitting postures to determine any significant differences and correlations. the findings are expected to provide insights into the relationship between sitting posture and pain, potentially guiding recommendations for ergonomic improvements.

Eligibility criteria:
inclusion criteria: * be between the ages of 18 and 65, not having undergone any surgery affecting spinal posture in the last two years exclusion criteria: * • psikiyatrik hastalık tanısı olması ya da tedavi alıyor olması omurganın duruşunun etkilenmesine sebep olabilecek nörolojik, romatizmal, ortopedik hastalık tanısı almış olmak
an initial safety study of gedatolisib plus ptk7-adc for metastatic triple-negative breast cancer

Conditions: Triple Negative Breast Cancer; Metastatic Breast Cancer

Summary: phase 1 study to evaluate the safety and effect of gedatolisib and ptk7-adc for the treatment of triple negative breast cancer


Eligibility criteria:
inclusion criteria: * metastatic triple-negative breast cancer * willingness to undergo tumor biopsy * patients must have received at least 1 prior chemotherapy regimen for metastatic disease exclusion criteria: * previous treatment with mtor inhibitor * untreated brain metastases

Keywords: breast cancer
job-site diet education on metabolic syndrome

Conditions: Metabolic Syndrome; Health Education; Workplace

Summary: this study conducted an 8-week workplace nutrition education intervention to examine the effects of the intervention on metabolic syndrome factors associated with employees. a historical intervention was designed to recruit adults with a body mass index level of \>22 and without any endocrine disorder from a community in yilan, taiwan. the intervention group was recruited between 2010 and 2012 and received an 8-week intervention, during which dietitians delivered a nutrition education session and a one-on-one dietary guidance session on a weekly basis. the age- and sex-matched control group (n = 34) was recruited between 2014 and 2015 to analyze the metabolic syndrome variables. the metabolic syndrome variables included blood pressure, blood sugar, serum lipid profile, and waist circumference.

content of classes week1 things that you must know during the weight reduction study period week2 daily individual calorie requirement: what are the main food groups? week3 how to record the daily diet after the weight reduction program week4 food serving size and replacement week5 the principles of eating out week6 physical activity advice (delivered with health education flyers to the participants)

Eligibility criteria:
inclusion criteria: * ≥ 18 years old * bmi of ≥ 22 exclusion criteria: * history of critical illness * having been diagnosed with at least one endocrine disorder
a phase ii study of topotecan in children with recurrent wilms tumor

Conditions: Wilms Tumor

Summary: in spite of the overall success of treating wilms tumor, certain patients still have poor clinical outcomes. the sub-optimal outcomes for patients with anaplastic histology and recurrent wilms tumor warrant the identification of new therapeutic agents. the objective of this trial is to estimate the response rate to two cycles of intravenous topotecan in children with recurrent wilms tumor of favorable histology that is refractory to standard curative therapy.

topotecan administered intravenously over 30 minutes daily for 5 consecutive days for 2 consecutive weeks, with a two-day rest given in between the five-day treatment blocks. the topotecan dose started at 1.8 mg/m2/dosage and adjusted to attain a target systemic exposure of 80 plus or minus 10 ng-hr/ml.each cycle consists of 28 days and subsequent cycles can be administered upon hematological recovery. patients with a cr, pr, or sd, can continue to receive up to a total of six cycles. patients with pd are removed from the study. secondary objectives include: * to describe the anti-tumor activity of topotecan in children with recurrent wilms tumor of anaplastic histology. * to assess the relation between cyp3a4/5 genotype and the pharmacokinetics and pharmacodynamics of topotecan. * to assess the relation between abcg2 genotype and the pharmacokinetics and pharmacodynamics of topotecan.

Eligibility criteria:
inclusion criteria: * favorable histology wilms tumor that has recurred or progressed after primary treatment and at least one standard salvage treatment regimen or anaplastic histology wilms tumor that has recurred or progressed after primary treatment * age\< 21 years of age at the time of study entry * adequate bone marrow function * adequate liver function * adequate renal function * adequate performance status exclusion criteria: * subject is pregnant * subject is lactating * renal tumors other than wilms tumors

Keywords: wilms tumor