Kornimate/medical-research-clean huggingface dataset:
can rhodiola crenulata intake improve oxygen saturation and decrease the incidence of acute mountain sickness

Conditions: Acute Mountain Sickness; Environmental Illness

Summary: traditional folk medicine in the arctic and himalayan areas used rhodiola species to enhance physical endurance, prevent aging, resist acute mountain sickness (ams), and to treat fatigue, depression, anemia, impotence and respiratory infections. rhodiola crenulata are widely used to prevent ams in himalayan areas and lhasa in tibet but none was examined by human study. the investigators conducted a randomized, double blind, placebo controlled, crossover study to investigate the efficacy of rhodiola crenulata in preventing ams.

the number of people traveling to altitude for work or for recreation is rising, and increased media attention towards these activities has also raised the profile of altitude related illness. the most effective preventive measure for acute mountain sickness (ams)-gradual ascent-is frequently difficult or impractical for modern international travel to locations such as lhasa in tibet (3650 m) and la paz in bolivia (3740 m). in order to solve this problem, prophylactic acetazolamide was most commonly used. but prescription needed and side effects such as paresthesia and nausea are the disadvantage of using acetazolamide. some over-the-counter herbal supplements with essentially no adverse effect were widely used, such as rhodiola species. rhodiola crenulata are widely used to prevent ams in himalayan areas and lhasa in tibet but none was examined by human study. the investigators conducted a randomized, double blind, placebo controlled, crossover study to investigate the efficacy of rhodiola crenulata in preventing ams.

Eligibility criteria:
inclusion criteria: * age between 20 and 55 years. * able to complete the study protocol of 9-day study regimens and mountain climbing twice. * no prophylactic medication or herb one month before ascent. * maintaining the same living conditions and habits four months before the first mountain climbing and four months between two mountaineering. * living in the same altitude or within a difference of 200 meters. * no additional physical training. * no plan to gain or loss weight. * no altitude exposure above 2500m. exclusion criteria: * any history of chronic obstructive pulmonary disease, heart failure, cerebral neoplasm, mania, renal or hepatic insufficiency. * women in pregnancy or intending of pregnancy during the 4-month study period.

Keywords: acute mountain sickness ams rhodiola crenulata mountaineering pulse oximetry oxygen saturation
automated bilingual computerized alcohol screening and intervention in latinos (ab-casi)

Conditions: Alcohol Dependence

Summary: to study the efficacy of ab-casi against standard of care in a randomized controlled trial in the emergency department.

the research team will rigorously test the efficacy of ab-casi, against a standard condition (sc) in a first-of-a-kind ed randomized controlled trial. studying an urban adult (≥ 18 y/o) latino ed population, the objectives are to demonstrate the superiority of ab-casi compared to sc in: 1) reduction of alcohol consumption (aims 1), 2) reduction of negative health behaviors and consequences (aim 2), and 3) increasing 30-day treatment engagement (aim 3). the investigators will also explore variation of the ab-casi intervention on alcohol consumption, alcohol-related negative health behaviors and consequences, and 30-day treatment engagement by latino subpopulations (puerto-rican, mexican-american, cuban-american, south/central american) as well as other potential modifiers (age, birthplace, gender, preferred language, reason for ed visit, and smoking status). english and spanish speaking latino adults presenting to the bridgeport hospital ed will be screened using the study inclusion and exclusion criteria. in march 2020, the primary and secondary outcomes were corrected to reflect the protocol as it was written initially. the citations section of this study registration also includes the citation for the published protocol manuscript.

Eligibility criteria:
inclusion criteria: * english and spanish speaking adult * ≥ 18 y/o * latino patients who present to the bridgeport hospital's ed * drink over the niaaa low-risk limits. exclusion criteria: * primary language other than english or spanish * current enrollment in an alcohol or substance abuse treatment program * current ed visit for acute psychosis * condition that precludes interview or ab-casi use i.e., life threatening injury/illness * in police custody * inability to provide two contact numbers for follow-up

Keywords: alcohol dependence alcoholism ab-casi emergency department
clinical trial for a outpatient clinical management of urgent laparoscopic appendectomy

Conditions: Appendicitis Acute; Appendicitis

Summary: the aim of this study is to evaluate the safety and efficacy of outpatient management of uncomplicated acute appendicitis. for this purpose, a randomized clinical trial was designed. selected patients who have undergone surgery for acute appendicitis are randomized into two groups. one group with hospitalization and another group without admission.

the aim of this study is to evaluate the efficacy and safety of outpatient management of laparoscopic appendicectomy in uncomplicated acute appendicitis. this was a single center randomized controlled clinical trial consisting in 2 treatment groups. patients were recruited in university hospital of tarragona joan xxiii of spain. all patients admitted in the emergency department at university hospital of tarragona joan xxiii with acute appendicitis diagnosis were likely to enter in the study. all patients who accomplished at least 4 over 5 of the saint-antoine criteria were included. the 5 criteria were: leukocytosis lower than 15.000; c-reactive protein lower than 30mg; body mass index lower than 30kg/m2; appendicular diameter lower than 10mm and no radiological sign of complication. all patients who met the inclusion criteria and none of the exclusion criteria were admitted to the study for emergency surgery. in order to avoid the biases a unique anesthetic and surgical protocol were established for both groups. once laparoscopic appendicectomy was performed the patients were randomly assigned to the hospitalization group or outpatient group. patients in the hospitalization group were admitted in the hospitalization ward. patients in the outpatient group were referred to the day-surgery unit where they were discharged according to aldrete criteria. the primary endpoint was the length of hospital stay (lhs). the length of hospital stay was calculated from the day and hour of admission in the surgical area to the day and hour of discharge, based on the hours of hospital stay. secondary endpoints included the failures of the outpatient management, readmissions and the hospitals cost.

Eligibility criteria:
inclusion criteria: * patients over 18 years old * meet at least 4 over 5 saint antoine criteria * asa classification (american society of anesthesiologists) less than or equal to 3 * patients who live accompanied in a home at a maximum distance of 30 minutes from the hospital and an adequate cognitive capacity. exclusion criteria: * pregnancy or breastfeeding * complicated acute appendicitis * surgical management performed in more 90 minutes.

Keywords: outpatient management laparoscopic appendicectomy
safety and efficacy study of artificial cornea

Conditions: Corneal Transplantation

Summary: the purpose of this study is to evaluate the stability of artificial cornea manufactured by aurolab and to assess its visual outcomes.

the keratoprosthesis, also know as an artificial cornea plays a significant role in combating corneal blindness in patients who are no longer candidates for penetrating keratoplasty.the global incidence of corneal blindness is estimated to be 6-8 million. in india there are approximately 6.8 million cases of unilateral corneal blindness and 1.3 million people with bilateral corneal pathology. eligible subjects after getting informed consent will be included in this study. all the subjects will have pre-operative evaluation which includes history, visual acuity, intraocular pressure (iop), evaluation of tear film and ultrasound a and b scan. ocular inflammation will be controlled prior to surgery. keratoplasty will be performed with keratoprosthesis under local anesthesia. patients will be followed up at regular interval to assess the outcome variables.

Eligibility criteria:
inclusion criteria: * age more than 20 years * willing to participate and review on schedule * multiple failed grafts with poor prognosis for regrafting * adequate tear film and lid function * projection of light in all quadrants * bilateral blind exclusion criteria: * reasonable chance of success with keratoplasty * autoimmune disease such as stevens johnson syndrome, pemphigoid * end stage glaucoma * retinal detachment

Keywords: cornea transplantation, cornea keratoplasty grafting, corneal
safety and efficacy of pmi-150 (intranasal ketamine) for the treatment of breakthrough pain in cancer patients

Conditions: Pain; Cancer

Summary: to assess the safety and efficacy of pmi-150 (intranasal ketamine) as an analgesic for the treatment of breakthrough pain in cancer patients.

the primary objective is to evaluate the safety and efficacy following the administration of intranasal ketamine in providing pain relief as compared to placebo.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * patients requiring around-the-clock opioids for pain due to cancer and with a history of experiencing episodes of breakthrough pain exclusion criteria: * under 18 years * non-cancer pain * allergy to ketamine

Keywords: breakthrough pain cancer
spanish real-world evidence cabozantinib

Conditions: Renal Cell Carcinoma

Summary: rcc (renal cell carcinoma) is the most common form of kidney cancer, accounting for 2-3% of all adult malignancies and for 90% of all kidney cancers. the incidence of rcc has steadily increased over the past two decades, showing a plateau in recent years. many patients with rcc remain asymptomatic until late disease stages and other patients have disease at diagnosis (metastatic rcc or mrcc). recently, the tyrosine kinase inhibitor (tki) cabozantinib was approved as a first-line therapy for patients with advanced clear-cell rcc (ccrcc). cabozantinib was initially approved for patients previously treated with antiangiogenic therapy based on the phase 3 meteor study, which demonstrated a clinical benefit compared with everolimus. immunotherapy has been also developed in ccrcc. the frontline treatment paradigm for ccrcc has evolved, particularly for intermediate-/poor-risk patients, with the recent addition of cabozantinib and nivolumab/ipilimumab (immunotherapy), but overall survival data are needed to understand their benefit-to-risk profiles compared with established therapies. in october 2016, the spanish agency of medicines (aemps) granted the temporary authorization for special use to cabometyx® 20/40/60 mg within a managed access program (map) for the treatment of advanced rcc in adults following prior vegf-targeted therapy (vascular endothelial growth factor targeted therapy). the map allows the possibility of using a medicinal product which is not yet commercially available or approved. by the end of the map period, on july 2017, 136 patients had been included by 61 centers who received at least one dose of cabometyx® for the treatment of advanced rcc. since then, cabometyx® 20/40/60 mg was made commercially available for the treatment of advanced rcc in adults following prior vegf-targeted therapy. after the commercialization of cabometyx® in july 2017 in spain, the inclusion of new patients in the map was closed but those patients that were already included continued receiving cabometyx® free of charge until clinical decision. in july 2018, the european commission approved a new indication for adult patients previously untreated with intermediate or poor risk. based on this rationale, the aim of this study is to obtain safety and effectiveness information regarding the use of cabozantinib in a non-selected rcc population, both in patients that received this agent under the map or under routine clinical prescription (real-world \[rw\]).


Eligibility criteria:
inclusion criteria: 1. male or females, aged 18 years or older. 2. diagnosis of advanced renal cell carcinoma (rcc) 3. alive or dead patients at study initiation who received at least one dose of cabozantinib for the treatment of rcc between october 2016 and 1 st june 2019. 4. alive patients who agree to participate and signed the informed consent form (icf). exclusion criteria: 1. patients who decline consent. 2. patients whose hospital medical records are unavailable for review.
the new biomarker of the knee osteoarthritis knee osteoarthritis occurrence and progression

Conditions: Knee Osteoarthritis

Summary: it was previously proved an association of tgf-β1 and pdgf-bb with the pathogenesis of osteoarthritis (oa) by experiments of oa animal models. in this study, we aimed to determine whether serum concentrations of tgf-β1, pdgf-bb and ctx-1 were related to the knee oa. knee oa cases were collected from the first affiliated hospital of shihezi university and healthy controls were recruited from the community. the severity of knee oa was defined as kellgren-lawrence (k-l) classification criteria.serum levels of chemical biomarkers were compared between knee oa cases and controls or among k-l grade 2 to grade 4 groups. the serum concentrations of the tgf-β1, pdgf-bb and ctx-1 were determined by elisa .


Eligibility criteria:
inclusion criteria: * oa diagnosis was on the basis of the diagnosis and treatment guideline of the american academy of orthopedic surgeons exclusion criteria: participants who met the following criteria were excluded： * the knee oa concomitant with hip oa, * suppurative and rheumatoid arthritis, * gout patients, * patients who underwent knee arthroscopy surgery within 6 months, * bilateral or unilateral knee replacements, * the knee joint trauma patients, * histories of glucocorticoid and/or sterol hormones.

Keywords: biomarkers
" acute brain changes after repetitive headers in soccer and the effects of a protective device "

Conditions: Traumatic Brain Injury; Concussion, Brain

Summary: soccer, the most popular sport in the world, exposes players to repeated head impacts and concussions, due to contact with another player or with the ground. moreover, routine game-play in soccer involves intentional and repeated head impacts through ball "heading", with frequent high velocities, which might cause a transient brain dysfunction. in this pre-post prospective interventional study, 22 soccer players will perform 10 headers from machine-projected soccer balls at standardized speeds, modelling routine soccer practice. they will perform heading series in 2 different oral conditions, on different days at least 1 week apart: 1) without mouthguard and tight jaws ; 2) with mouthguard and tight jaws. the strength of the neck muscles will be measured before the heading series. the kinematic of the movement will be recorded during each impact during the 2 heading series, as well as the activity of the jaw muscles which will be recorded by electromyogram. before and after each heading series, electrophysiological data, multimodal magnetic resonance imaging (mri), and cognitive computerized assessment will be acquired


Eligibility criteria:
inclusion criteria: male 18 to 25 years, enrolled in french social security, recruited from the soccer teams of the university of bordeaux exclusion criteria: * abnormal neurological examination * taking drugs targeting the central nervous system * any unhealed injury * history of head trauma, or other notion of central nervous system injury * history of severe high blood pressure, diabetes, chronic cardiovascular pathology, progressive or debilitating disease * family history of epilepsy * contraindication to mri: head circumference\> 60 - claustrophobia - pacemaker, implantable neurostimulation, implantable defibrillator - cochlear implants - ocular or cerebral ferromagnetic foreign body - refusal to be informed of an anomaly detected with mri * individuals under legal protection or unable of giving their informed consent

Keywords: soccer traumatic brain injury heading acceleration neuroimaging cognition
quantitative genetic analysis of lipid research clinic family data

Conditions: Cardiovascular Diseases; Heart Diseases; Coronary Disease; Tangier Disease; Atherosclerosis

Summary: to assess the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia and to resolve genetic and familial environmental effects on several phenotypes of importance to coronary heart disease.

background: although coronary heart disease has long been known to aggregate in families, in 1986 little was known about the relative importance of genetic and environmental factors. this was partly due to the heterogeneous nature of the disease. instead of analyzing complex endpoints, the tendency had been to focus on the individual risk factors or phenotypes. plasma lipids and lipoproteins are heterogeneous risk factors that have been analyzed as subgroups from a genetic epidemiological perspective. attention turned to the familial aggregation of risk factors, particularly the hyperlipidemias, hypertension, and diabetes. in 1971, the national heart and lung institute began a series of epidemiologic studies at several north american sites under the lipid research clinics program. the family study was designed to investigate the familial association of blood lipids, lipoproteins, and dyslipoproteinemias. this study complemented and did not duplicate ongoing analysis of lipid research clinics data. design narrative: the study addressed seven phenotypes, all derived from fasting blood samples: total cholesterol, total triglyceride, ldl-cholesterol, hdl-cholesterol, vldl-cholesterol, uric acid, and glucose levels. the data had already been collected at lipid research clinics in cincinnati, iowa, oklahoma, minneapolis, and stanford. univariate and bivariate segregation analysis were conducted on the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia. path analysis was used to resolve cultural and biological inheritance for each phenotype within each clinic and for resolution of population heterogeneity among the five lipid research clinics. a general bivariate path model was used to analyze the associations among the various phenotypes. general models were used to analyze temporal trends in family resemblance for the seven phenotypes. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
database of all patients who have undergone pulmonary function testing at singapore general hospital

Conditions: Obstructive Pulmonary Diseases; Restrictive Lung Disease; Cough; Dyspnea

Summary: the purpose of this study is to create a prospective database of all patients who have undergone pulmonary function testing from which the investigators can study the clinical phenotypes of various respiratory conditions. the investigators hope by understanding the differences in these myriad phenotypes to be able to provide individualized, patient-targeted therapy in the future.

recent studies have shown that clinical phenotyping of patients with various respiratory conditions is important in the understanding of the disease process, clinical response to treatment, and prognosis. pulmonary function testing is a very important aspect of clinical phenotyping in many respiratory conditions. creating a database will enable us to study the various phenotypes within each respiratory condition. this will allow us to better understand each disease, with a view to provide personalized patient care targeted at their specific phenotype and hence better clinical outcomes.

Eligibility criteria:
inclusion criteria: 1) all patients who have undergone pulmonary function testing at the singapore general hospital pulmonary function laboratory

Keywords: obstructive lung disease restrictive lung disease cough dyspnea
the serum sclerostin levels in cholesteatoma patients

Conditions: Otitis Media Chronic; Cholesteatoma

Summary: the aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. so far, there is no study showing the levels of sclerostin in cholesteatoma. the investigators hope that the results of our study will start new processes that can be used in the clinic.

chronic otitis media (com) is the perforation of the eardrum and mucosal inflammation of the space in the middle ear and the air cavities of the temporal bone over a period of three months. although com is defined as a multifactorial disease, its etiopathogenesis has not been fully elucidated. cholesteatoma is a condition that disrupts the balance between bone formation and resorption in com. the cholesteatoma is a destructive squamous epithelial lesion of temporal bone, it gradually expands and leads to serious complications by the destruction of near bone structures, ossicular chain and otic capsule. a growing debate examines the role of bone formation and destruction with osteoblasts, osteocytes and osteoclast cells in cholesteatoma formation. sclerostin is a glycoprotein that plays a role in the regulation of bone metabolism secreted by osteocytes. antibodies directed against sclerostin stimulate bone formation and represent a new therapeutic option for the treatment of increased bone resorption diseases, such as osteoporosis and generalized bone loss, inflammatory diseases with cartilage damage. the aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. so far, there is no study showing the levels of sclerostin in cholesteatoma. the investigators hope that the results of our study will start new processes that can be used in the clinic.

Eligibility criteria:
inclusion criteria: cholesteatoma chronic otitis media exclusion criteria: acute infection malignancy

Keywords: otitis media chronic cholesteatoma sclerostin
arterial stiffness, wave reflections and renal failure

Conditions: Chronic Renal Failure; Arterial Stiffness; Arterial Wave Reflections

Summary: 1. cardiovascular risk is high in patients with renal failure. 2. cross-sectional studies have indicated a relationship between arterial stiffness and renal function. however, there are no prospective longitudinal studies in the literature. 3. in dialysis patients, arterial stiffness as well as wave reflections, predict mortality. however, there are no data on patients with mild-to-moderate renal impairment available. 4. therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure


Eligibility criteria:
inclusion criteria: * chronic renal failure patients (kdoqi iii, iv) undergoing regular control visits at our nephrology department * \> 19 years * written informed consent exclusion criteria: * atrial fibrillation * valvular heart disease * severely impaired systolic function * no informed consent

Keywords: chronic renal failure arterial stiffness arterial wave reflections