Kornimate/medical-research-clean huggingface dataset:
evaluating right ventricular (rv) size and function using the upper valley rv algorithm and novel imaging modalities

Conditions: Pulmonary Hypertension; Valvular Heart Disease; Congenital Heart Disease; Congestive Heart Failure; Pulmonary Embolism; Acute Coronary Syndrome

Summary: the primary purpose of this study is to evaluate the diagnostic performance of three methods for measuring right ventricular size and function including the philips novel rv quantification technologies (rv heart model volumetric analysis and philips 2d strain) and the upper valley right ventricle algorithm (uvrv) algorithm as compared to the gold standard of volumetric analysis via cardiac magnetic resonance imaging (cmr) in a broad patient population.

this is a single-center, blinded, randomized control trial of patients 18-years or older that are undergoing cmr as a standard of care at dartmouth-hitchcock medical center in lebanon, nh. after informed consent is obtained, subjects undergo a study-specific external, non-invasive echocardiogram utilizing a special rv focused protocol on the same day of their cmr as close to their scheduled cmr as possible to minimize wait time for consented patients. the echocardiogram takes approximately an additional 30 minutes of the subject's time. de-identified echocardiogram images from each subject will be evaluated by experienced echocardiographers using three different methodologies (standard method, phillips novel technology and the newly developed uvrv algorithm). the methodologies will be compared with each other to determine sensitivity, specificity and accuracy.

Eligibility criteria:
inclusion criteria: * patient age is over 18 years * patient is undergoing cardiac mri with sequences that permit biventricular volumetric analysis * patient is capable of giving informed consent * the cardiac mri images are of diagnostic quality to provide accurate rv and lv volumes exclusion criteria: - patient unable to under echocardiogram
proton pump inhibitor (ppi) inappropriate use and economic burden in chinese population

Conditions: Gastrointestinal Disease

Summary: this is a descriptive retrospective database analysis study in using database. all patients with a physician ppi prescription will be selected to estimate the ppi inappropriate use.

study primary objective is to identify the inappropriate use of ppi (overall, outpatient \& inpatient).

Eligibility criteria:
inclusion criteria: * all patients in 2015 china health insurance research association (chira) database. * patients had ppi prescription during jan. 2015 to dec. 2015 will be selected to estimate the ppi inappropriate use. exclusion criteria: • patients without data of treatment information.

Keywords: stress ulcer prevention
study evaluating the efficacy and safety of desvenlafaxine tablets in adult outpatients with major depressive disorder

Conditions: Depressive Disorder, Major

Summary: the primary objective is to compare the antidepressant efficacy, safety, and tolerability of dvs sr versus placebo in subjects with major depressive disorder. additional objectives include testing both general and functional quality-of-life outcomes and satisfaction with therapy reported by the subject.


Eligibility criteria:
inclusion criteria: * a primary diagnosis of mdd * depressive symptoms for at least 30 days before the screening visit. exclusion criteria: * treatment with dvs sr at any time in the past. * known hypersensitivity to venlafaxine * significant risk of suicide based on clinical judgment

Keywords: depression adult outpatients
therapeutic alliance is it associated with better compliance amongst children with juvenile idiopathic arthritis ?

Conditions: Juvenile Idiopathic Arthritis

Summary: to evalute if therapeutic alliance is related to adherence in jia

the therapeutic alliance is the agreement that is being built between doctor and patient during the construction process of care. so active collaboration based on a shared assessment of issues and agreement on possible solutions. initially described in psychiatry, this analytical concept has been extended to several chronic diseases in particular requiring more often a strong link between doctor and patient. his measure is important since it has been demonstrated by several previous studies that the therapeutic alliance is predictive of the therapeutic effects of treatment. this alliance, however, was little studied in juvenile idiopathic arthritis, its connection with the observance or the quality of life has never been evaluated. the chronic nature of juvenile idiopathic arthritis (jia) requires a strong ability of the child to follow his treatment, where the role of parents going to be important and where the relationship built with the caregiver is also essential. adherence is a complex concept for which there is no ideal measure. direct evaluation criteria such as bioassays prove still incomplete and difficult to implement in observational studies. indirect measures have been developed through self-administered questionnaires and literature showed their relatively good correlation with actual catches. the innovative hypothesis of this research is that a better therapeutic alliance is associated with better adherence child in jia.

Eligibility criteria:
inclusion criteria: * patients with jia (see classification above) * aged at least 8 to 18 years. * having already seen more than 2 times in consultation with the referring physician will even include the child in the study so that the alliance could build process * children can read, understand and complete questionnaires * no opposition made exclusion criteria: * systemic form of jia; * children aged under 8 years old or over 18 years; * child or parent does not understand french * refusal of participation
different antihypertensive drugs on aortic diseases

Conditions: Aortic Aneurysm; Aortic Dissection

Summary: the goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. the main question it aims to answer is: does different hypotensive drugs influence the prognosis of postoperative aortic patients? as participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

this study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. the study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the eighth affiliated hospital and beijing anzhen cardiothoracic surgery center. patients were assigned based on the postoperative antihypertensive medication regimens. datas was collected to compare the cardiovascular-related prognoses. this study primarily includes patients who take oral antihypertensive medications after aortic surgery. the main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Eligibility criteria:
inclusion criteria: * aortic diseases\&#39; patients underwent aortic surgery who require antihypertensive medication. exclusion criteria: * patients with active vasculitis; * patients allergic to contrast agent * patients with aorta variation
comparison between rectal & sublingual misoprostol before caesarian section to reduce intra & post-operative blood loss

Conditions: Postpartum Hemorrhage

Summary: the aim of the work is to evaluate \& compare the effectiveness of rectally administered pge1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood loss during and after the operation.


Eligibility criteria:
inclusion criteria: 1. patients booked for elective cesarean section. 2. singleton pregnancies. 3- full term pregnancies (ga 37-42 weeks). 4- patients with only previous one cesarian section exclusion criteria: 1. primigravida. 2. blood dyscrasias. 3. large fibroids. 4. multiple pregnancies. 5. overdistended uterus eg. hydramnios. 6. pre-eclampsia. 7. marked maternal anemia (preoperative hemoglobin \< 9 gm/dl). 8. previous history of pph. 9. contraindications to prostaglandin therapy (e.g. history of severe bronchial asthma or allergy to misoprostol. 10. placenta previa. 11. contraindication to spinal anesthesia. 12. previous myomectomy. 13. previous two or more c.s.

Keywords: postpartum hemorrhage intrapartum blood loss misoprostol
a study of ibandronate (bondronat) in participants with metastatic bone disease

Conditions: Pain; Bone Neoplasms; Neoplasm Metastasis

Summary: this study will evaluate the efficacy, safety, and effect on quality of life of oral ibandronate (bondronat) in participants with breast cancer and metastatic bone disease. the anticipated time on study treatment is 25 weeks, and the target sample size is 50 individuals.


Eligibility criteria:
inclusion criteria: * females at least 18 years of age * breast cancer * bone metastases exclusion criteria: * use of bisphosphonates within the last 3 months * prior use of gallium nitrate or metastron * severely impaired renal function * hypocalcemia or primary hyperparathyroidism * central nervous system (cns) metastases
the effect of neurofeedback-assisted mindfulness training in employees with emotional labor

Conditions: Stress, Psychological

Summary: the purpose of this study is to verify the effect of neurofeedback-assisted mindfulness training for workers. subjects who can participate in the screening are assigned to one neurofeedback-assisted mindfulness training group, mindfulness only training group, and self-treatment group. the neurofeedback-assisted mindfulness group and the mindfulness group meet with psychologist and have education for the mindfulness training with or without neurofeedback respectively, a total of 4 times, once a week. on the other hand, the self-treatment group provides self-education by providing the stress education kit.

after screening, pre-evaluation is conducted on the subjects who agreed to participate in the study. pre-assessment includes questionnaires related to stress, emotional labor, resilience, sleep, etc., and includes stress-related physiological measures using hrv, 2 lead eeg. after the pre-evaluation, the neurofeedback-assisted mindfulness and mindfulness training group will have education sessions with a psychologist for 30 minutes at a time, once a week, for a total of 4 sessions (one month for a period). the education includes the instruction of the application including mindfulness training, with or without neurofeedback, and the review for the accomplishment of the training. participants should follow the instruction and the training schedule which is arranged in advance. on the other hand, for a self-care control, the education sessions are not provided and self-learning materials are provided once a week. the purpose of the study is to find the effectiveness of mindfulness training on reduction of stress and severity of emotional labor. especially, mindfulness training group with neurofeedback might be expected to show the highest improvement in various clinical scales and biomarkers including eeg and hrv.

Eligibility criteria:
inclusion criteria: * workers over the age of 19 and under 65 * in the perceived stress scale 14 points or more * if you are currently taking medication due to psychiatric illnesses such as depression, anxiety disorder, insomnia, etc., the dose must be stabilized for last 6 months, is expected to have no change in drug dose during the clinical trial * if you understand the protocol and voluntarily agree to participate * if you have an android phone exclusion criteria: * age under 19, adult over 65 * if you have dementia, intellectual disability, or other cognitive impairment * if you have convulsive disorder, stroke, or other neurological disorder * if you have psychosis such as schizophrenia or bipolar disorder or you have a history * if you have a disease that can affect the reliability of hrv test, such as heart disease or lung disease. * has received non-pharmacological psychiatric or counseling treatment within the current or last 6 months.

Keywords: resilience emotional labor mindfulness neurofeedback
f-choline pet in early response assessment for castration resistant prostatic cancer

Conditions: Castration-resistant Prostate Cancer

Summary: until today no current diagnostic tool exists to identify an early objective response when patients with castration-resistant prostate cancer were treated by abiraterone acetate or enzalutamide. according to the prostate cancer working group, the investigators have to wait 12 weeks before the first evaluation. to know soon that the treatment is effective will be decisive for the oncologist, even more in palliative situation where second effects can't be imposed to patients. in post-docetaxel, the f-choline pet-ct could be used to assess the response of this new therapy. moreover, the investigators suppose that we can assess an early stage if there is an objective therapeutic response, at 6 weeks of treatment, in order to avoid unnecessarily and expansive treatment. the aim of this study is to assess if it is possible to determine early (6 weeks of treatment)if a f-choline pet-ct could predict the response to abiraterone acetate or enzalutamide in post-docetaxel.


Eligibility criteria:
inclusion criteria: * age \> 18 years * eastern cooperative oncology group (ecog)performance status score of 2 or less * histologically or cytologically confirmed adenocarcinoma prostate cancer without neuroendocrine component (component with minority neuroendocrine) or small cell, or neuroendocrine cells or small minority component prostate who underwent surgical or medical castration * disease progression during or after a docetaxel-based chemotherapy * serum testosterone level of 50 ng per deciliter or less (≤2.0 nmol per liter) * biologic criteria : * platelets ≥ 100 000/μl, * creatinine \<1.5 x upper limit or creatinine clearance ≥ 60 ml / min, * serum potassium ≥ 3.5 mmol / l, * bilirubin \<1.5 x upper limit of normal (uln) * hemoglobin ≥ 9.0 g / dl without any transfusion. exclusion criteria: * abnormal aminotransferase levels (levels of aspartate aminotransferase or alanine aminotransferase that were ≥2.5 times the upper level of the normal range; patients with known liver metastasis who had levels of aspartate aminotransferase or alanine aminotransferase that were ≤5 times the upper level of the normal range were eligible to participate * previous therapy with ketoconazole * serious coexisting nonmalignant disease : * active or symptomatic viral hepatitis or chronic liver disease, * uncontrolled hypertension, * a history of pituitary or adrenal dysfunction, * clinically significant heart disease

Keywords: castration-resistant prostate cancer abiraterone acetate enzalutamide choline pet
effect of progressive exercise on renal transplant patients

Conditions: Renal Transplant; Fatigue; Vital Signs; Progressive Relaxation Exercise; Nursing

Summary: the goal of this interventional study is to determine the effect of progressive relaxation exercises on the vital signs and fatigue levels of patients with renal transplantation.

renal transplant patients experience intense level of fatigue as well as vital sign problems due to treatment protocol. this research is designed to determine the effect of progressive relaxation exercises on vital signs and fatigue level of patients with renal transplantation. in this study, the participants will be randomized in a single blind manner (participant) to either intervention (4 week exercise program) or control (routine care) groups.

Eligibility criteria:
inclusion criteria: * patients underwent renal transplant within one year from the beginning of the study * patients having no communication problems * patients having a smart phone either own or o family member exclusion criteria: * patients having musculoskeletal, cardiopulmonary, or psychiatric disorders
evaluation of styloid chain calcification to the patient with the temporomandibular joint disorder

Conditions: Styloid-Stylohoid Syndrome; Temporomandibular Disorder

Summary: the aim of the study was to evaluate any relation between elongated styloid process (esp) and type of temporomandibular joint disorders (tmd).

the styloid process (sp) of the temporal bone is a long conical cartilaginous projection lies anterior to the mastoid process. patients who have esp or styloid chain calcification are usually asymptomatic, only 4% are symptomatic. symptoms vary as different syndromes which related affected anatomic structures by calcified process or ligament. temporomandibular dysfunction (tmd) describe the temporomandibular joint (tmj) disfunction that divided three branches according to temporomandibular joint's disc status: non-displacement (nd), displacement with reduction (dwr) and displacement without reduction (dwor). since orofacial pain shows similar features in both esp or styloid chain calcification and tmd, it is possible to confuse and misdiagnosis both of these clinical conditions. this study aimed to investigate the length and calcification pattern of the styloid process in patients with tmd diagnosis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of temporomandibular dysfunction(tmd) * tmd patients with mr and cbct images recorded in the digital archive. exclusion criteria: * operated or treated for any temporomandibular joint diseases * head and neck trauma * orthodontic treatment

Keywords: magnetic resonance imaging cone beam computed tomography temporomandibular dysfunction styloid-stylohoid syndrome
efficacy of mindfulness therapy in orofacial chronic pain

Conditions: Mindfulness; Chronic Pain; Orofacial Pain

Summary: psychological impairments have a significant role in management and coping of pain in patients with orofacial pain disorders. the response of this kind of pathologies to topical or systemic medications is not predictable and mindfulness breathing and relaxation techniques could present good results since it help patients to accept their problem and to cope it. in consequence, the present study is aimed to evaluate the efficacy of a mindfulness therapy program in management of chronic orofacial pain.


Eligibility criteria:
inclusion criteria: * patients diagnosed of orofacial chronic pain by a physician. exclusion criteria: * pain with oncologic origin * severe mental disorder

Keywords: mindfulness chronic pain orofacial pain
mk-0431 early phase ii double-blind study - type 2 diabetes mellitus (0431-043)

Conditions: Type 2 Diabetes Mellitus

Summary: a clinical study to determine the safety and efficacy of mk-0431 in patients with type 2 diabetes mellitus who have inadequate glycemic control on diet/exercise therapy


Eligibility criteria:
inclusion criteria: * patients have type 2 diabetes mellitus * on diet/exercise therapy exclusion criteria: * patients have type 1 diabetes mellitus
social and psychological impacts of sars-cov-2 pandemic period in the obese population.

Conditions: Obesity; Covid19

Summary: the population suffering from obesity is particularly at risk during this pandemic period. the nouvelle aquitaine region is not spared, since according to the regional epidemiological report of 7 may 2020, carried out by santé publique france, 39.2% of cases admitted to the intensive care unit in nouvelle aquitaine and presenting risk factors are overweight or obese. other risk factors, such as social-environmental factors, must be taken into consideration. socio-demographic surveys in this area highlight the socio-economic and territorial inequalities that interfere with obesity issues. similarly, the issues of stigmatisation and isolation seem to be at the heart of the question of how to deal with these people.

this is a prospective multicentre study. participating patients will be recruited from the specialised obesity centres (chu and ssr, as well as patient associations) to fill in a questionnaire and take part in an interview (a varied panel representative of the target population in terms of place of residence, socio-professional category, sex and age). the medical and paramedical staff involved in the partner csos and the patients' resources (identified by the patients' associations) will also be asked to participate in a semi-directive interview.

Eligibility criteria:
inclusion criteria: * patients 18 years of age. * be registered in an active file of the 3 partner csos. exclusion criteria: * patients under 18 years of age. * patients under protective measures or deprived of liberty: * pregnant or breastfeeding woman, * under guardianship, * under guardianship, * safeguard of justice, * incarcerated.

Keywords: obesity covid19 semi-directive interview
a multicenter prospective randomized controlled study of rpd versus lpd

Conditions: Pancreatic Cancer; Common Bile Duct Diseases; Periampullary Carcinoma

Summary: laparoscopic pancreaticoduodenectomy(lpd) and robot pancreaticoduodenectomy (rpd), as two minimally invasive methods of pancreaticoduodenectomy(pd), have obvious advantages over traditional open pancreaticoduodenectomy(opd) in terms of reducing surgical trauma and hospitalization time, but there are few studies on their perioperative safety and prognostic effects.however, there are few studies on the perioperative safety and prognostic effects of both procedures. in this trial, the perioperative data and prognosis of both procedures were collected and analyzed through a prospective, multicenter approach to investigate the advantages and disadvantages of both procedures.

in this trial, subjects proposed for pd were randomly divided into two groups, lpd and rpd, according to inclusion and exclusion criteria. patients in both groups were operated and received perioperative management under the same surgical team and were operated according to the standard pd surgical approach. subsequently, perioperative clinical data and long-term prognostic data of subjects in both groups will be collected and statistically analyzed to explore a better surgical approach.

Eligibility criteria:
inclusion criteria: * over 18 years old * preoperative imaging suggested the presence of space occupying in the head of the pancreas, ampullary abdomen, and distal common bile duct tumor lesions to be treated with pancreaticoduodenectomy * no distant transfer * no significant vascular invasion was received exclusion criteria: * with tumors of other organs * patients unable to tolerate anesthesia and operation due to serious abnormalities in functions of heart, lung and other important organs * patients found intraoperative peripheral organ metastasis combined with excision of other organs or found intraoperative radical excision could not be performed and underwent palliative drainage surgery or end the surgery * preoperative adjuvant therapy was given

Keywords: robot pancreaticoduodenectomy laparoscopic pancreaticoduodenectomy randomized controlled trial safety and efficacy