Kornimate/medical-research-clean huggingface dataset:
nutritional effect of an amino acid mixture on lean body mass (lbm) in post-bariatric surgery patients

Conditions: Obesity; Post-gastric Bypass

Summary: the focus of this study is to look at the role of nutrition in maintaining lean body mass post-gastric bypass surgery. the purpose of this study is to test whether lbm is increased in those patients receiving a nutritional supplement of amino acids is enhanced when compared to control patients not receiving the supplement.

you are being asked to participate in a pilot (initial) research study designed to test how effectively a nutritional supplement, juven, helps people keep lean muscle mass (the amount of muscle tissue in your body) and sustain weight loss after gastric bypass surgery. abbott laboratories, the manufacturer of juven, sponsors this research study. juven is commercially available without prescription in the united states. if you decide to participate, you will have a dexa scan to check your lean body mass, an indirect calorimetry (your breath is collected for a period of time and is analyzed) test to check your basal metabolic rate (how much energy your body uses at rest), and a blood test to check your certain hormone made by your intestines (bowel or guts). each of these tests will be run on you three times. once, before your gastric bypass surgery, once 2 weeks after your surgery and once two months after your surgery. if you qualify for the study, you will be randomly (like the flip of a coin) assigned by a computer to receive either juven twice a day by mouth, or to continue with standard care. as part of your normal post-operative instructions, you should avoid becoming pregnant for two years after your surgery. acceptable forms of birth control after gastric bypass include barrier methods (condoms, diaphragm, etc.), depo-provera (the shot) and nuva-ring (vaginal ring). the birth control pill is not as reliable after gastric bypass because its absorption is unpredictable. the effects of juven in pregnant women have not been tested. if you should become pregnant, you should stop taking juven and notify dr. clements or his staff.

Eligibility criteria:
inclusion criteria: * each person who has been judged to be an acceptable candidate for laparoscopic gastric bypass (lgb) will be asked to participate in this protocol when they are scheduled for the operation. exclusion criteria: * age less than 18 * pregnant females * weight greater than the limit of the dexa table (patients over 300 pounds) * known allergy to any component fo the amino acid supplement

Keywords: morbid obesity lean body mass amino acid supplement laparoscopic gastric bypass
comparative effect of accelerated rehabilitation and eccentric strengthening exercises on patients with at

Conditions: Achilles Tendinopathy

Summary: a common overuse injury to the achilles tendon, achilles tendinopathy frequently causes pain, restricted range of motion, and functional impairment.

the purpose of this randomized clinical research is to evaluate the benefits of eccentric strengthening exercises and rapid rehabilitation on achilles tendinopathy patients. using techniques including tens, isometric exercises, balance training, and endurance exercises, the 12-week accelerated rehabilitation program emphasizes pain management, mobility restoration, and functional recovery through incremental phases. however, in order to improve tendon strength and resilience, eccentric strengthening entails progressively raising resistance and functional loading. both approaches are backed by earlier research but lack direct comparison in terms of effectiveness. this study will open the door for more research and improve rehabilitation techniques worldwide by adding to the expanding corpus of material on achilles tendinopathy care.

Eligibility criteria:
inclusion criteria: * male and female patients, age greater than 18 years, clinically diagnosed with achilles tendinopathy. * participants that are clinically diagnosed with achilles tendinopathy. * duration of symptoms or pain for more than 1 month. * positive clinical tests, such as thompson test, confirming achilles tendinopathy. * tenderness to palpation along the achilles tendon or localized pain during activity. * patients with a history of overuse injuries related to repetitive activities, such as running or jumping. exclusion criteria: * following participants will be excluded from this study: * presence of systemic conditions such as rheumatoid arthritis, diabetes, or other inflammatory or neuromuscular disorders. * history of complete achilles tendon rupture or previous surgical intervention on the affected tendon. * patients with other lower limb injuries or conditions (e.g., fractures, ligament tears) that could interfere with achilles tendinopathy treatment. * severe tendon degeneration or calcification confirmed by imaging, unsuitable for rehabilitation.
a multicenter study on early diagnosis of nste-acs patients based on machine learning model

Conditions: NSTEMI - Non-ST Segment Elevation MI; Unstable Angina

Summary: early diagnosis of nstemi and ua patients is mainly through the construction of machine learning model.

the patients with nstemi and ua were included. after manual labeling, the admiss- ion record characteristics of patients were selected. 75% of the data is used to build the model, and 25% of the data is used to verify the validity of the model. five classification models of one-dimensional convolution (cnn), naive bayesian (nb), support vector machine (svm), random forest (rf) and ensemble learning were constructed to identify and diagnose nstemi and ua patients. multi-fold cross-validation and roc-auc curve are used to measure the advantages and disadvantages of the models.

Eligibility criteria:
inclusion criteria: * patients were included and excluded strictly according to the diagnostic criteria of chinese guidelines for diagnosis and treatment of non-stsegment elevation acute coronary syndrome (2016). the patients were admitted to the hospital with chest pain as the main complaint, and were admitted to the first affiliated hospital of xinjiang medical university and the first affiliated hospital of medical college of shihezi univ- ersity. the patients were diagnosed as nstemi and ua by coronary angiography (age range from 30 to 75 years old). exclusion criteria: - 1. patients with stemi, aortic dissecting aneurysm, pneumothorax and other non-cardiogenic chest pain. 2.severe hepatorenal failure, primary tumor without surgical treatment, non-severe infection complicated with shock and pregnant women. 3.previous severe valvular disease, viral myocarditis, pericardial effusion, cardiac pacemaker implantation, cardiogenic shock with serious complications, hypertensive heart disease, various cardiomyopathy, congenital heart disease, etc. 4.patients with heart disease, aecopd, lung tumor and hyperthyroidism were diagnosed in the past.

Keywords: nstemi ua machine learning
the evaluation of bepreve on the measurement of wheal and flare response from histamine skin prick testing

Conditions: Histamine Responsive Allergy Patients

Summary: to evaluate the effect of bepreve compared to a refresh tears lubricant eye drop on the measurement of the wheal and flare from histamine skin prick testing. this is an open label, two-week, post-marketing study conducted on histamine responsive patients.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects, 18 to 65 years of age * patients must demonstrate a positive reaction to a histamine skin-prick test. manifested by a histamine-induced wheal of \>3mm in diameter over the normal saline control after 15 minutes of elapsed time exclusion criteria: * significant signs and symptoms of currently active allergic disease (sar, perennial allergic rhinitis, episodic allergic rhinitis) * upper respiratory tract infection, sinusitis, asthma or flu-like symptoms within 2 weeks prior to visit 1 * subjects who have dermatographism or other skin conditions which might interfere with the interpretation of the skin test results * subjects who are receiving escalating doses of immunotherapy, oral immunotherapy or short course (rush) immunotherapy * known hypersensitivity to the investigational product or to drugs with similar chemical properties * pregnancy and/or breast feeding * use of antihistamines, nsaids, steroids, or other drugs which may affect the skin-response * use of any medications or agents that are not specified above that may confound the interpretation of the results

Keywords: allergic conjunctivitis histamine skin testing
serologic assays for the diagnosis of herpes simplex virus type 2

Conditions: Genital Herpes

Summary: the purposes of this study are: * to determine the accuracy of commercially available serologic assays in diagnosing patients with herpes simplex virus type 2 (hsv-2); * to assess the sensitivity and specificity of the commerical assays using hsv-2 western blot as the "gold standard" in a diverse patient population; * to develop testing strategies and recommendations for screening asymptomatic populations for hsv-2.

the purposes of this study are: * to determine the accuracy of commercially available serologic assays in diagnosing patients with herpes simplex virus type 2 (hsv-2); * to assess the sensitivity and specificity of the commerical assays using hsv-2 western blot as the "gold standard" in a diverse patient population; * to develop testing strategies and recommendations for screening asymptomatic populations for hsv-2. we will evaluate the assays in diverse populations: 1. std clinic population 2. men who have sex with men, with high prevalence of hiv infection 3. pregnant women the study will inform the development of testing strategies: 1. combine commercial tests to optimize positive predict value (ppv) and negative predict value (npv) 2. increase cutoff values to increase ppv 3. understand factors associated with false positive results that may include hsv-1 infection, pregnancy status, hiv infection, and age/race etc.

Eligibility criteria:
inclusion criteria: * men and women 16-55 years of age exclusion criteria: * those who refuse to get tested for hiv

Keywords: hsv-2 hsv-1 sensitivity specificity testing algorithm test evaluation
volatile organic compounds (vocs) and liver diseases

Conditions: Liver Diseases

Summary: liver diseases such as non-alcoholic fatty liver disease (nafld), alcoholic liver disease (ald) and viral hepatitis have the potential to progress to cirrhosis and finally hepatocellular carcinoma (hcc). early diagnosis and treatment of liver diseases is important since progression is likely and is associated with significant morbidity and mortality. however, in daily clinical practice no specific and non-invasive biomarkers are used for the diagnosis and follow-up of patients with liver diseases. it is known that patients with liver diseases produce compounds that can be excreted in breath as a consequence of metabolic processes, inflammation and/or oxidative stress. these are called volatile organic compounds (vocs). analysis of vocs in exhaled air has been reported to provide valuable information in patients with chronic obstructive lung disease (copd) and inflammatory bowel disease (ibd). also, in patients with liver disease, exhaled vocs have been detected. the investigators hypothesize that analysis of vocs in exhaled air of patients with liver diseases can be used for diagnosis and follow-up.


Eligibility criteria:
inclusion criteria: * established diagnosis of liver diseases based on laboratory, radiological and histological characteristics * age between 18 and 85 years exclusion criteria: * inflammatory bowel disease * chronic obstructive lung disease, lung cancer, asthma * rheumatoid arthritis

Keywords: liver diseases volatile organic compounds inflammation oxidative stress non-invasive tests
comparison of the bioavailability of metformin between medium dose linagliptin/metformin tablets and medium dose glucophage tablet given with linagliptin tablet

Conditions: Diabetes Mellitus, Type 2

Summary: the data from this study will be used to compare the kinetic profile of metformin 500mg in linagliptin/metformin fixed dose combination tablet versus canadian metformin reference product administered concomitantly with linagliptin 2.5 mg tablet.


Eligibility criteria:
inclusion criteria: 1. healthy male and female subjects. exclusion criteria: 1. any relevant deviation from healthy conditions.
long-term prognosis of cluster headache: a retrospective cohort study

Conditions: Cluster Headache; Disease Course

Summary: cluster headache is a syndrome characterized by disabling headache and accompanying autonomic symptoms. despite cluster headache is called "suicide headache", its natural history has not been well investigated. the investigators aimed to investigate its disease course, overall prognosis, and treatment pattern in retrospective cohort.


Eligibility criteria:
inclusion criteria: * patients who were diagnosed as cluster headache * more than 5 years after the first visit exclusion criteria: * subjects who refused the telephone visit
double filtration plasmapheresis (dfpp) and lipid metabolism

Conditions: DFPP and Platelet Function

Summary: little clinic trials showed that double filtration plasmapheresis (dfpp) could improve lipid metabolism, however, whether dfpp can improve platelet function and recover endothelial function is unknown. in this study, we try to confirm the hypothesis that dfpp can improve endothelial function in hyperlipidemia patients.


Eligibility criteria:
inclusion criteria: 1. hyperlipidemia exclusion criteria: 1. severe liver and kidney dysfunction 2. severe cardiopulmonary insufficiency 3. tumor 4. pregnancy
omegaven in patients with rheumatoid arthritis (ora-trial)

Conditions: Rheumatoid Arthritis

Summary: the primary hypothesis constitutes that the fish-oil preparation (omegaven) is superior to the preparation based on soja-oil (lipovenös)to reduce signs and symptoms in patients with active rheumatoid arthritis.

the study can be considered a phase iii trial (comparison of two licensed preparations in a non-approved indication). this controlled double blind trial aims to compare the effect of parenterally applied fat emulsions on the disease activity of ra patients, as expressed by changes of the das28. to test for the hypothesis patients are randomized and treated with 2ml/kg bodyweight of both preparations for seven consecutive days. these treatment cycles are repeated four times at monthly intervals. for not improving patients (das28 decrease \<0.6) escapes before the third and the fourth treatment cycle are foreseen. in case of escape patients are treated with omegaven in an open manner. efficacy parameters comprise the das28, the acr-criteria, the m-haq, the sf-36, and the co-medication consumption. to assess safety laboratory parameters, comprising, lft, kft, cbc, fasting glucose, cholesterol, hdl, ldl, neutral fat, and urinary analysis are performed. moreover, blood pressure control and clinically examinations are performed on a regular basis. study recruitment started in fall 2004 and was completed in november 2006.

Eligibility criteria:
inclusion criteria: * written informed consent * ra according to the acr criteria * active ra (das28 \> 4.0) at the screening visit * insignificant das28-change (\<0.6) between screening and the first intervention exclusion criteria: * age lower than 18 yrs. * pregnancy and insufficient birth control * lactation * army service * lack of independence * relevant therapeutic or dietary changes during the last three months * relevant therapeutic or dietary changes foreseen for the study duration (including surgery) * application of omega-3 fatty acids during the last three months * application of omega-3 fatty acids intended for the study duration * prednisolone \> 10 mg/day * contraindication for omegaven or lipovenös (according to the label)

Keywords: treatment disease activity clinical trial
well being and rehabilitation in chronically ill patients: structured patient education and physical exercise

Conditions: Chronic Obstructive Pulmonary Disease; Heart Failure; Stroke

Summary: this study addresses self management and maintenance of health through evaluation of a program of patient education in combination with physical training and with a structured follow-up. it is hypothesized that such a program will: 1. improve quality of life, physical functioning, coping in everyday-life 2. reduce hospitalization and (re-)admissions for patients with chronic disease, reduce consumption of home care services and can increase consumption of general practice and physiotherapy services in primary health care. 3. improve patient satisfaction and health care providers satisfaction

patients with chronically, long-lasting illness, have complex needs for treatment and care, which none of the service providers can fulfill on their own. both patients and their relatives are in danger of experiencing severe lack of quality. integrated care path programs are increasingly put into use. there is insufficient research-based documentation of the effect of such care paths. the available documentation of different integrated care paths emphasizes early mobilization and discharge, rehabilitation in familiar surroundings, more effective communication and exchange of competence between the different service providers and educational self-management for patients as main elements in order to expect effect. there are no studies that evaluate the effect of quality of life, functional skills and personal coping if group-based educational self management is combined with physical exercise and patients with different chronically illnesses participate in the same group.

Eligibility criteria:
inclusion criteria: * 45 years of age or more * living at home * capable of active participation in a group setting * walking distance within 550 meter in 6 minutes * chronic obstructive pulmonary disease (copd) i-iii * chronic heart disease i-iii * stroke(0-2 on modified rankin scale) exclusion criteria: * speaking and language problems or other substantial communication problems * unstable medical or social situation * participation in another science study

Keywords: chronic obstructive pulmonary disease heart failure stroke quality of life self management education physical exercise primary health care
effect of acupuncture therapy on dysphagic parkinson's patients

Conditions: Dysphagia

Summary: we are currently conducting a randomized controlled study in china, specifically in three hospitals' rehabilitation medicine departments, focusing on dysphagic participants with parkinson's disease. the aim of our study is to evaluate the effectiveness of acupuncture therapy as an additional intervention for these participants. participants were randomly assigned to either the experimental group or the control group, with 56 individuals in each group. both groups are receiving standard treatment and swallowing rehabilitation training, while the experimental group is also receiving acupuncture therapy. our study aims to provide valuable insights into the potential benefits of acupuncture in improving swallowing difficulties in parkinson's disease participants.

we are currently conducting a randomized controlled study in china, specifically in three hospitals' rehabilitation medicine departments, focusing on dysphagic participants with parkinson's disease. the aim of our study is to evaluate the effectiveness of acupuncture therapy as an additional intervention for these participants. participants were randomly assigned to either the experimental group or the control group, with 56 individuals in each group. both groups are receiving standard treatment and swallowing rehabilitation training, while the experimental group is also receiving acupuncture therapy. our study aims to provide valuable insights into the potential benefits of acupuncture in improving swallowing difficulties in parkinson's disease participants. the study lasted 42 days (6 weeks) for each participant. specifically, our main focus is on the study of lianquan, shanglianquan (depression between the hyoid bone and the lower border of the mandible), yifeng, fengchi, wangu, fengfu, yamen, neidaying (depression of 1 inch below the anterior margin of the mandible), jinjin, yuye, posterior pharyngeal wall (both sides of the uvula).

Eligibility criteria:
inclusion criteria: * age \>18 years. * meeting the diagnostic criteria for parkinson's disease. * diagnosed with dysphagia confirmed by the video fluoroscopic swallowing study. * water swallow test\> level 3. * stable vital signs, conscious, able to cooperate with assessment and treatment. exclusion criteria: * dysphagia possibly caused by other reasons, such as cerebrovascular disease, trauma, neuromuscular diseases, malignant diseases of the pharynx and larynx, and digestive tract diseases. * history of mental diseases or use of antipsychotics. * complicated with cognitive impairment or consciousness dysfunction. * simultaneously suffering from severe liver, kidney failure, tumors, or hematological diseases.
vfend special investigation for pediatric - observational

Conditions: Pediatric Safety and Effectiveness

Summary: examine the safety and effectiveness of vfend \[voriconazole\] for pediatric under general clinical practices.


Eligibility criteria:
inclusion criteria: * patients who is under 15 years old and deep mycosis infection. exclusion criteria: * patients who have been previously enrolled in this study. -
novel hemostatic cardiac risk factors in framingham

Conditions: Cardiovascular Diseases; Heart Diseases; Death, Sudden, Cardiac; Myocardial Infarction; Thrombosis; Atherosclerosis; Carotid Artery Diseases

Summary: to investigate hemostatic variables in relation to cardiovascular risk in the framingham offspring study cohort.

background: elevation of platelet reactivity plasminogen activator inhibitor, fibrinogen, von willebrand's factor, and factor vii have been reported to increase myocardial infarction risk. myocardial infarction and sudden cardiac death are more frequent in the morning when platelet activity is increased and fibrinolysis is decreased. reduction of recurrent myocardial infarction by aspirin and coumadin suggests causal roles for platelet activity and coagulation. increases in viscosity and decreases in anti-thrombin iii and protein c have been linked with increased thrombosis. despite these findings, a coherent picture of these disparate hemostatic indices as cardiac risk factors has yet to emerge. design narrative: platelet reactivty, plasminogen activatator inhibitor, fibrinogen, von willebrand's factor, factor vii, and other hemostatic risk factors were measured in all 4,000 subjects of the framingham offspring study. the data were combined with the regularly collected framingham data to: determine the relationships between hemostatic factors and carotid atherosclerosis as assessed by ultrasound; determine the relationship between hemostatic factors and the traditional cardiac risk factors; and determine if hemostatic risk factors independently predict myocardial infarction and cardiac death. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria