Kornimate/medical-research-clean huggingface dataset:
validation of the turkish swallowing disturbance questionnaire

Conditions: Parkinson Disease; Dysphagia

Summary: purpose of the study is the validity and reliability of the turkish version of the swallowing disturbance questionnaire (sdq-t), so that it would be used as an assessment tool for turkish parkinson disease's (pd) patients. despite being translated and validated in many languages, there is no validated turkish version of sdq to measure the severity of dysphagia in pd.

parkinson's disease (pd) patients who suffered from dysphagia have reported significantly reduced quality of life. the swallow function is a multidirectional process that depends on complex neuro-muscular network. the function can be evaluated using instrumental, such as fibreoptic endoscopic evaluation of swallowing (fees), videofluoroscopy, or well structured questionnaires. there are many questionnaire and scales for assessment of dysphagia in pd but very few have been validated. the study will assess the construct validity and reliability of the turkish version of swallowing disturbance questionnaire. the investigators developed the turkish version of this questionnaire (sdq-t), according to the cross-cultural adaptation guidelines. two translators translated the sdq into turkish and a native english language speaker reverse-translated it into english. the back translation was sent to the original author for proofreading. the sdq questionnaire consisted of 15 basic questions related with dysphagia symptoms in pd patients.

Eligibility criteria:
inclusion criteria: * diagnosed with parkinson's disease * able to speak, read, understand and write in turkish * taking food orally * malignancy * having an active infection * advanced demans or exclusion criteria: * diagnosed with other neurodegenerative disorders. * able not to speak, read, understand and write in turkish * advanced demeans or other cognitive limitations * underwent any surgery last six months * pregnancy * underwent laryngectomy/neck dissection/tracheostomy/neck radiotherapy * out of age 18-80 years old.

Keywords: parkinson's disease dysphagia questionnaire swallowing validation
cognitive changes with gabapentin treatment

Conditions: Neuralgia Peripheral; Pain

Summary: this is a single-cohort, prospective, observational study evaluating the effects of gabapentin on cognition. the goal of the study is to determine whether there is a measurable change in cognitive function from baseline in patients who are prescribed gabapentin for the treatment of neuropathic pain.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 85 2. diagnosis of neuropathic pain 3. patient report of average daily pain intensity in the last week \>3 on 0-10 numerical rating scale (nrs). 4. able and willing to sign an irb-approved written informed consent exclusion criteria: 1. current pregabalin treatment 2. patient has started taking a new pain medication, or has changed their pain medication dose, in the past 4 weeks. 3. treatment with opioids exceeding 60mg mme. 4. severe cognitive impairment that is documented in medical chart.
subcutaneously cm310/placebo in patients with moderate-to-severe atopic dermatitis (ad)

Conditions: Moderate-to-severe Atopic Dermatitis

Summary: this is a multi-center, randomized, double blind, placebo-controlled phase iib study to evaluate the efficacy, safety, pk, pd and immunogenicity of cm310 in moderate-severe ad subjects. the study consists of 3 periods, a up-to-4-week screening period, a 16-week randomized treatment period and a 8-week safety follow-up period.

subjects will be required to apply moisturizers after icf signed and continue throughout the study.

Eligibility criteria:
inclusion criteria: * diagnosed as ad for at least 12 months before screening, with below requirements: 1)easi score ≥16 at screening and baseline; 2) iga score ≥3 (0-5 points scale) at screening and baseline; 3) ≥10% bsa of ad involvement at screening and baseline; 4) pruritus nrs average score ≥3 at baseline. * inadequate response to topical medications. exclusion criteria: * not enough washing-out period for previous therapy. * concurrent disease/status which may potentially affect the efficacy/safety judgement. * organ dysfunction. * pregnancy. * other.

Keywords: atopic dermatitis
a randomized, placebo-controlled, double-blind study of tianshu capsule in the treatment of migraine.

Conditions: Migraine

Summary: the purpose of this study is to evaluate the safety and the efficacy of tianshu capsule treating migraine headache.

primary headache disorders,particularly migraine is globally prevalent. many studies show the burdens they impose: pain, disability, reduced quality of life (qol), marked impairment of participation in work and social activities, and heavy financial costs. the purpose of this study is to evaluate the safety and the efficacy of tianshu capsule treating migraine headache. to provide a safe and effective treatment of migraine headache.

Eligibility criteria:
inclusion criteria: * must meet the migraine diagnosis. * age of onset should be before age 50 years. * migraine must have been occurring for 1 year preceding entry into the trial. * the number of migraine attack should be no less than 6 for a period of 3 months prior to screening stage. * the number of migraine days is to be 2-8 for a period of 1 month prior to screening for entry into the trial. * migraine days should be less than 15 for a period of 1 month prior to screening for entry into the trial. * ages 18-65. * participant can understand and complete the headache diary. * all participants signed the informed consent. exclusion criteria: * other migraine prophylactic medication is continued 3 months prior to the drug trial. * participants who have taken tianshu capsule during 1 month prior to screening stage. * the number of acute treatment for migraine is more than 10 per month. * participants who have taken antipsychotics or antidepressant medications (unless only for migraine prophylaxis) during the previous 3 months. * participants who abuse alcohol or other drugs. * participants who are resistant to all acute migraine drugs prescribed optimally. * hypotension or uncontrolled hypertension. * severe infections. * malignancy. * significant medical history of such as cardiac disease, cerebrovascular disease, liver disease, nephropathy etc. * known allergies or serious side effects with tianshu capsule in the past. * breastfeeding, pregnant and potentially fertile women participant. * history of cluster headaches, tension-type headache, vascular headache with non-migraine, drug - dependence headache. * secondary headaches, including hypertension, post-traumatic brain syndrome etc. * participants who have taken migraine prophylactic medication regularly during 1 month prior to screening stage. * participants who are taking part in other clinical trials.

Keywords: migraine tianshu capsule
the effect of inspiratory muscle warm-up on decreased diffusing capacity for carbon monoxide after maximal exercise in athletes

Conditions: Athlete

Summary: this study aims to examine the effects of inspiratory muscle warm-up (imw) on the gas exchange capacity of the lungs (dlco) and its potential contribution to recovery and athletic performance in elite athletes from various disciplines. the study hypothesizes that the decline in respiratory muscle capacity following high-intensity exercise, which negatively affects ventilation, diffusion, and oxygen transport, may be ameliorated through specific imw protocol. a placebo-controlled, randomized, crossover, and double-blind design will be utilized, involving 28 elite male athletes from endurance, power, skill-based, and mixed disciplines. participants will complete three warm-up protocols: general warm-up (gw), general warm-up combined with imw at 40% resistance intensity (gw+imw40%), and a placebo condition (gw+imwplacebo). measurements will include respiratory muscle strength, dlco (assessed at post-2, 30, 60, 90, and 120 minutes), respiratory function, and cardiorespiratory parameters during maximal exercise. this study is unique as it aims to detail the micro-level effects of imw on pulmonary diffusion mechanisms and performance outcomes, providing novel insights into the ameliorative effects of imw on respiratory function post-exercise. additionally, it seeks to expand understanding of the mechanistic basis of imw's benefits on both pulmonary diffusion capacity and athletic performance.

study design this study will employ a placebo-controlled, randomized, crossover, and double-blind research design to evaluate the effects of three warm-up conditions: control, placebo 15%, and imw 40%. athletes will be randomly assigned to the conditions using a crossover approach, ensuring that all participants will experience each protocol on separate days. the warm-up protocols will include: general warm-up (control): a standard warm-up without resistance. imw 40%: a general warm-up combined with inspiratory muscle warm-up at 40% resistance intensity. placebo 15%: a general warm-up combined with inspiratory muscle warm-up (placebo) at 15% resistance intensity. blinding will be maintained for both participants and researchers. participants will be informed that the study aims to investigate various warm-up types, while the true purpose will remain concealed. this design will ensure reliability and minimize bias in the data to be collected.

Eligibility criteria:
inclusion criteria: * age between 18-24 years. * a training history of at least six years. * regular training frequency of at least four sessions per week. exclusion criteria: * history of smoking. * history of physical disability or acute respiratory or cardiovascular disease within the past three months. * diagnosis of sars-cov-2 within the past three months. * pulmonary function measurements outside the normal clinical range (≤ 80%).

Keywords: warm-up inspiratory muscle warm-up respiratory muscle warm-up
a study of alg-055009 in healthy volunteers and subjects with hyperlipidemia

Conditions: NASH - Nonalcoholic Steatohepatitis

Summary: a randomized study of alg-055009 drug to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses in healthy volunteers and subjects with hyperlipidemia


Eligibility criteria:
inclusion criteria for healthy subjects: 1. male and female between 18 and 55 years old 2. bmi 18.0 to 32.0 kg/m\^2 inclusion criteria for subjects with mild hyperlipidemia: 1. male and female between 18 and 65 years old 2. bmi 18.0 to 35.0 kg/m\^2 3. subject must be on a stable diet for the 3 months prior to screening with a fasting ldl-c level \>110 mg/dl at screening exclusion criteria for all subjects: 1. subjects with any current or previous illness that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results' interpretation 2. subjects with hepatitis a, b, c or hiv-1/hiv-2 infection or acute infections such as sars- cov-2 infection 3. subjects with renal dysfunction (e.g., estimated creatinine clearance \<90 ml/min/1.73 m\^2 at screening, calculated by the chronic kidney disease epidemiology collaboration \[ckd-epi\] formula) 4. subjects with history of thyroid disorder or abnormal thyroid function tests at screening or known sensitivity to thyroid medications 5. subjects receiving, or urgently requiring, any lipid lowering therapy
abdominal massage with tens on parasacral versus sacral area on symptom,severity & qol in chronic constipation females.

Conditions: Constipation

Summary: constipation is infrequent or difficult evacuation of feces. these symptoms are associated with a variety of causes, including low dietary fiber intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. patients complaining of constipation may mean different things by the term the frequency of their bowel actions may be less than 'normal', their stools maybe difficult to pass, or they may have a sense of malaise or abdominal discomfort which they attribute to a 'sluggish bowel', though the stool frequency and consistency are apparently normal. objective of this study is to compare effects of abdominal massage. withtensonparasacralversussacralareaonsymptomseverityandqualityoflifein severechronicconstipationamongyoungfemales.

this study will be a randomized clinical trial and will be conducted at services hospital in lahore. the study will be completed with in the time duration of eight months. purposive sampling technique will be used to collect the data. a sample size of total 24 patients will be taken in this study. patients will be divided into two groups.(group a will be treated with tens on sacral area and abdominal massage where as group b will be treated with tens on par sacral area and abdominal massage).pac-sym questionaire,pac-qol questionaire will be used to ask some questions related to patients 'symptoms and abdominal cramps or bloating.. all participants of the study will fill the pac-symq and pac-qol q on day 1 as pre treatment values and at the end of 4th session as post treatment values respectively. the collected data will be analyzed on spss-25. keywords : constipation, quality of life , abdominal massage.

Eligibility criteria:
inclusion criteria: * age between 14 -35year * only females * laxatives at least once or more for 2weeks * non pregnant * chronic constipation more then 6 months exclusion criteria: * organic dysphasia or secondary constipation caused by laxatives for unrelated conditions. * pregnant females suspected pregnant subjects, as well as those who were breast-feeding * non co-operative patients * female with underlying disease

Keywords: constipation quality of life abdominal massage
prospective randomized trial on comparison of standard- carbon dioxide pressure pneumoperitoneum insufflators versus airseal

Conditions: Colorectal Disorders; Hernia; Incidence for Cholecystectomy

Summary: the primary objective of the present trial is to investigate, the mean operative time and to study the frequency and intensity of postoperative shoulder tip pain in patients undergoing laparoscopic surgery, i.e. cholecystectomy, colorectal surgery, hernia repair with airseal® compared with standard pressure co2 insufflation systems. the primary hypothesis is that patients operated with airseal® have a shorter mean operative time and decreased frequency and intensity of postoperative shoulder tip pain compared with patients undergoing surgery with standard pressure co2 insufflation systems. it is the secondary objective of the trial to evaluate immunologic and anaesthesiological aspects of laparoscopic cholecystectomy, colorectal surgery and laparoscopic hernia repair by observing the immune responses and volume of mechanical ventilation of the two groups through measuring various immunologic factors and ventilation volume/co2 elimination volume. surgical side effects will also be measured as secondary objective.


Eligibility criteria:
inclusion criteria: * patients recruited for laparoscopic surgery i.e. cholecystectomy, colorectal surgery, hernia repair * written informed consent * ≥ 18 years of age exclusion criteria: * patients with known immunological dysfunction (advanced liver disease, hiv, hepatitis c virus infection), drug addiction * ≤18 years of age * pregnancy and lactation * previous extensive abdominal surgery * acute surgical intervention
efficacy of a new topical anesthetic

Conditions: Pain

Summary: a new topical anesthetic which contains 5% lidocaine and a disinfection ingredient has been developed and is tested in this study (lidodyn). the study examines the efficacy of lidodyn by comparing it with an already proven anesthetic agent (emla crème).


Eligibility criteria:
inclusion criteria: * previously healthy children of whom venipuncture is needed to be performed. exclusion criteria: * history of allergic reaction to any local anesthetic. * history of chronic disease * patient's condition requires urgent treatment (e.g. severe dehydration, shock) * active local skin infection or skin pathologic condition at the antecubital fossa * tattoo, surgical scar or skin condition that might interfere with skin sight assessment. * patient undergone venipuncture at the antecubital fossa within the pror two weeks. * uncooperative or exceptionally anxious patient.

Keywords: children
effect of doxycycline on cardiac remodelling in stemi patients

Conditions: ST Elevation Myocardial Infarction; Anterior Wall Myocardial Infarction; Heart Failure; Remodeling, Ventricular

Summary: subsequent to the loss of myocardium post-myocardial infarction (mi), the affected ventricle undergoes some dynamic structural and functional changes known as remodeling. cardiac remodeling progresses into heart failure (hf). in this revolutionized percutaneous coronary intervention (pci) era, the incidence of post-mi hf due to cardiac remodeling remains high. current standard therapeutic interventions, for hf, aimed solely at correcting a low cardiac output do not necessarily impede hf progression. recently, doxycycline was found to have an additional biological effect aside from their antimicrobial actions. from several experimental studies and clinical trials, doxycycline showed mmp inhibition activities that can prevent ventricular remodeling. this study aims to evaluate the role of doxycycline in cardiac remodeling prevention post-mi. our hypothesis is that a better heart function will be observed in stemi patients who receive a short period of doxycycline administration post-pci.


Eligibility criteria:
inclusion criteria: * onset of stemi \<12 hours * anterior wall stemi or killip grade ii-iii or lvef \<50% * undergoing primary pci exclusion criteria: * signs of infection (clinical judgement plus leukocyte count \>15,000) * stemi mechanical complication * moderate-severe valvular disease * allergic to doxycycline * refuse to join the trial

Keywords: doxycycline cardiac remodelling stemi
ultrasound guidance of office hysteroscopy in patients with history of failure of office hysteroscopy due to cervical stenosis.

Conditions: Hysteroscopy

Summary: the study is conducted to assess whether ultrasound guidance can facilitate the access of the office hysteroscope into the uterine cavity of patients with previous failure of office hysteroscopy due to cervical stenosis.


Eligibility criteria:
inclusion criteria: * patients with history of failure of office hysteroscopy exclusion criteria: * pelvic inflammatory disease * severe vaginal bleeding * pregnancy * allergy to lidocaine, prilocaine or diclofenac potassium

Keywords: hysteroscopy ultrasound pain
interest of nutritional care of children with sickle cell disease on bone mineral density and body composition

Conditions: Sickle Cell Disease; Osteoporosis; Osteopenia

Summary: this study is design to assess the effects of an increase in nutritional intake on the bone mineral density of children with sickle cell disease, for 12 months.

* sickle cell disease is the most common inherited disease of the red blood cell * during sickle cell disease, the decrease in bone mineral density (bmd) in children is very common: 19 and 56% depending on the studies * children with sickle cell disease have an increase in resting energy expenditure of 15-20% * children with sickle cell disease have a significant decrease in muscle mass * there are no specific nutritional recommendations for sickle cell disease in children our main purpose is to assess the effects of an increase in nutritional intake on the bone mineral density of children with sickle cell disease, for 12 months our secondary objectives are : 1. / evaluate the effects of an increase in nutritional intake on: body composition, height and weight growth, frequency of complications of sickle cell disease, school absenteeism, cardiac function, cerebral vasculopathy, biological parameters follow-up, and the relationship with the treatment started 2. / creation of a sero-type blood bank for future research

Eligibility criteria:
inclusion criteria: * following genotypes of sickle cell disease: ss, sc, se, sbeta + or sbeta0 * ages 3 to 16 years old exclusion criteria: * overweight at the start of the study * child for whom one of the 2 parents refuses his child's participation in the study

Keywords: sickle cell disease osteoporosis osteopenia bone mineral density nutrition body composition oral nutritional supplement
families, responsibility, education, support, and health for executive function

Conditions: Overweight and Obesity; Attention-Deficit Hyperactivity Disorder

Summary: the pilot study will be a one group open-label treatment program and will be used to refine a parent-based behavioral treatment enhanced with executive-function training (pbt-ef) for children with comorbid overweight or obesity and attention-deficit hyperactivity disorder (adhd).

the currently recommended treatment for children with overweight or obesity (ow/ob), family-based behavioral treatment (fbt), results in sustained weight loss for only 1/3 of children. attention-deficit hyperactivity disorder (adhd) is one of the most common neurobehavioral disorders in children and is characterized by difficulties in executive function (ef). substantial research suggests higher rates of ow/ob in children with adhd; thus, children with ow/ob and adhd are likely to have greater difficulties with ef and achieving success in fbt. the proposed study aims to develop a parent-based behavioral treatment enhanced with ef training (pbt-ef) to improve treatment outcomes for children with comorbid ow/ob and adhd. the treatment will be administered to parents in 18 group sessions over 5 months. parents and children will be assessed at baseline, post-treatment, and 3-month follow-up. assessments will include body mass index (bmi), assessments of executive function, and behavioral questionnaires. this study could provide a novel model to treat ow/ob in children with adhd, and could inform clinical decision making regarding obesity treatment.

Eligibility criteria:
inclusion criteria: * child with overweight or obesity (85-99.9% bmi for age), * child age 8-12, * child with a diagnosis of adhd, * a parent willing to participate who can read and understand english at a minimum of a fifth-grade level, able to attend treatment sessions remotely via zoom on video. exclusion criteria: * current enrollment in an organized weight control program (parent and child) * medication specifically prescribed for weight loss (child) * medical or psychiatric condition that may interfere with treatment participation or that may require physician monitoring of diet and/or exercise (e.g., acute suicidality; psychosis; substance use disorder) (parent and child) * change in psychotropic medication or other medication that may impact weight or adhd symptoms during the previous 3 months (child)

Keywords: weight loss executive function parent-based treatment