Kornimate/medical-research-clean huggingface dataset:
prospective study of quality of life in non-small cell lung cancer (nsclc) patients treated with/without postoperative radiotherapy

Conditions: Non-Small Cell Lung Cancer

Summary: the patients from 12 centers were included into the study. pn2 patients received port, pn1 patients did not. port was 3d-planned and consisted in 54-56 gy in 27-28 fractions. one month after surgery, all patients completed eortc qlq c-30 questionnaires and had pulmonary function tests (pft); cardiopulmonary symptoms were assessed by modified lent-som score. two years after, all patients free of disease repeated the same examinations. changes in qlq, lent-som score and the results of pft were compared for patients receiving and not port.


Eligibility criteria:
inclusion criteria: * complete resection by lobectomy, bi-lobectomy or pneumonectomy of nsclc, * pn1 or pn2 disease, * signed informed consent for participation in the study, * karnofsky performance status (kps) higher than 70%. exclusion criteria: * presence of distant metastases, * n2 diagnosed before surgery in imaging and/or mediastinoscopy, * previous radiotherapy to the chest, * no or inadequate mediastinal nodal dissection , * fev1 after surgery lower than 1.0 liter, * any active infectious process (including fistula formation) in the chest

Keywords: nsclc, port, quality of life, pulmonary function after rt
the effect of dopamine on mechanical ventilation induced lung injury

Conditions: Acute Lung Injury

Summary: dopamine(da) is a common neurotransmitter that has been known to regulate behavior, movement, cardiovascular，endocrine and gastrointestinal functions, but also functions as an important molecule engaging in the immune systems to possess anti-inflammatory effects. however, its role in ventilator-induced lung injury (vili) is still unclear. herein, this study aimed to investigate the therapeutic efficacy of dopamine on ventilation-induced lung endothelial barrier dysfunction and explore the possible underlying molecular mechanisms.

mechanical ventilation is a critical intervention for patients with acute respiratory failure. however, lung overdistension induced by mechanical ventilation at high tidal volumes also causes pulmonary endothelial dysfunction. the injurious effect of mechanical stretch on pulmonary endothelium has been implicated in the development of ventilator-induced lung injury (vili), which is characterized by pulmonary inflammation and particularly increased vascular permeability. in addition, the investigators and others have previously shown that mechanical stretch increases cultured lung endothelial monolayer permeability in vitro and promotes lung vascular permeability in mice thus, elucidating the mechanisms underlying the mechanical stretch-induced lung endothelial barrier dysfunction may provide a novel clinical therapeutic target against vili. dopamine is a neurotransmitter, which can also be produced outside the central nervous system. lung alveolar epithelial cells represent an important source of extraneuronal dopamine, which has a significant role in local organ physiology. dopamine d1 receptor (drd1) and d2 receptor (drd2) are present in lung tissues. activation of d2dr induces nakatpase gene expression. moreover, activation of drd1 results in the trafficking of nakatpase to the basolateral membrane of type ii alveolar epithelial cells, thus increasing lung liquid clearance during acute lung injury. although the lung-protective effects of da and its implication in the pathology of ali are emerging, the mechanisms are still largely unknown. in the present study, the investigators will analyze the influence of mechanical ventilation on dopamine receptors in the lung tissue of the participants, and explore whether da could protect ventilation induced lung injury, which is helpful for prevention and treatment of ventilation induced lung injury.

Eligibility criteria:
inclusion criteria: * patients inclusion criteria: undergo elective lobectomy with general anesthesia and mechanical ventilation; classified as physical status i to iii according to the american society of anesthesiologists physical status classification system; written informed consent is approved. exclusion criteria: * distant metastases: recent anaesthetics or mechanical ventilation treatment；children；women during pregnancy or lactation; being involved in other clinical subjects.

Keywords: dopamine,mechanical ventilation,lung injury
efficacyof pilates exercises in lowback pain

Conditions: Low Back Pain; Physical Therapy; Pilates

Summary: objective: to investigate the effects of pilates exercise by training the muscles responsible for core stabilization in patients with chronic non-specific low back pain (cnlpb); considering pain, functional level, depression, quality of life, and muscle thickness measured by ultrasound imaging and to compare it with home based exercise. material and methods: a prospective, randomized-single blinded study included 60 female patients with cnlbp aged 18-60 years. patients were randomized into 2 groups. the first group (n=30) performed pilates 3 days/week for 8 weeks. sessions lasted about one hour and supervised by a pilates trainer. the second group (n=30) was given home exercise program 3 times/week for 8 weeks, each session lasting one hour. the evaluations were made both at the beginning and end of the treatment. evaluation parameters included vas (visual analogue scale), oswestry disability index, qubec disability scale, short form-36 (sf-36), beck depression questionnaire, sit and reach test, modified schöber test, sit up test. multifidus and abdominal muscle thickness were measured by ultrasonographic imaging.

a prospective, randomized-single blinded study included 60 female patients with cnlbp aged 18-60 years. patients were randomized into 2 groups. the first group (n=30) performed pilates 3 days/week for 8 weeks. sessions lasted about one hour and supervised by a pilates trainer. the second group (n=30) was given home exercise program 3 times/week for 8 weeks, each session lasting one hour. the evaluations were made both at the beginning and end of the treatment. evaluation parameters included vas (visual analogue scale), oswestry disability index, qubec disability scale, short form-36 (sf-36), beck depression questionnaire, sit and reach test, modified schöber test, sit up test. multifidus and abdominal muscle thickness were measured by ultrasonographic imaging.

Eligibility criteria:
inclusion criteria: * chronic non-specific low back pain for \>3 months, * visual analog scale (vas) score of 3-6 * female patients aged 18-60 years, * body mass index (bmi) within normal limits (18.5-24.9 kg/m²) * ability to continue the program. exclusion criteria: * malignancies, * infections * inflammatory diseases * severe osteoporosis, * arthritis * metabolic bone diseases * pregnancy * cardiovascular diseases that limit effort capacity * other musculoskeletal conditions that may impede attaining positions required in exercises * a history of spinal surgery * cognitive impairment.

Keywords: abdominal muscles exercise therapy low back pain paraspinal muscles
efficacy of electric 3d versus manual toothbrushes in patients with fixed orthodontic appliances

Conditions: Gingivitis; Dental Plaque

Summary: this study evaluates if electric toothbrushes with a 3d action (rotation / oscillation and pulsation) are more effective than manual toothbrushes in removing plaque and reducing gingival inflammation in patients under orthodontic treatment with fixed appliances.

this trial is designed as a randomized, controlled, investigator blinded superiority trial, with two parallel groups and a 1:1 allocation ratio. equal number of males and females will be allocated to each group. one group of orthodontic patients will receive an electric toothbrush with orthodontic head and the other group will receive a manual orthodontic brush. tooth brushing instructions will be provided. measurements of two plaque indices and two gingival indices will be taken at baseline and at 3 monthly intervals.

Eligibility criteria:
inclusion criteria: - age between 12 and 16 years. good general health according to a recent full medical history. fixed labial orthodontic appliances on all teeth from central incisor to first molar (bands on first molars, metallic brackets-conventional, not self ligating-on other teeth), in both the maxillary and the mandibular arch, placed at least two months before the patient is accepted into the study and no more than two years. non-extraction orthodontic treatment. plaque-induced gingivitis: patients will be included if they have gingival bleeding on at least 30% of the sites examined using the criteria for bleeding of the modified simplified gingival index. exclusion criteria: - active caries. periodontitis. tooth agenesis (excluding third molars). syndromes and craniofacial deformities. current use of electric toothbrush. more than two cervical and/or proximal fillings. dental prostheses or dental implants. smoking or use of other tobacco products. antibiotics during the last 2 months. medication that may result in gingival enlargement (e.g. anticonvulsants, immunosuppressants, calcium channel blockers). disabilities that might affect toothbrushing skills (manual dexterity, mental disabilities). peri-oral or intra-oral piercing. cardiac or other medical condition that requires antibiotic prophylaxis for dental treatment. participation in other trials.
regional prophylactic vancomycin in revision total knee replacement

Conditions: Arthropathy of Knee Joint

Summary: the purpose of this study is to determine whether or not giving a lower dose of antibiotics (vancomycin) in the area where it is needed (the knee joint) is more effective at preventing infection than the current standard dose which is given intravenously (iv) through a wrist vein.

patients were assigned to one of two groups by chance (like a coin toss): * group 1 - received 500mg of vancomycin into the tibia (shin) bone of the leg being operated on. * group 2 - received 1g of vancomycin, which is the amount normally given to patients. for both groups, the revision knee replacement will then be carried out as normal. other antibiotics all patients received cefazolin iv (an antibiotic used to prevent infection) prior to the beginning of surgery to ensure effective preventive antibiotics. the patient will also received 3 postoperative doses of cefazolin over a 24-hour period (4 doses in total). this is standard of care for all total knee replacement surgeries. tissue samples * ten (10) tissue samples were taken during the surgery, consisting of both bone and fat beneath the skin. each sample were very small, around the size of a pinhead. * in addition, a drain sample was taken from the knee joint drain fluid to measure vancomycin concentration the morning following surgery. * these samples were frozen and sent to a lab for analysis.

Eligibility criteria:
inclusion criteria: * revision total knee arthroplasty * informed consent given exclusion criteria: * current treatment with iv vancomycin within the preceding 7 days * previous hypersensitivity to vancomycin * significant cardiac or respiratory abnormality * contraindications to using the intraosseous vascular access system (ez-io) * sepsis

Keywords: revision knee joint
quality of life in children cured of retinoblastoma

Conditions: Retinoblastoma

Summary: the aim of the study is to assess the quality of life of children who have been cured of retinoblastoma - a malignant eye tumor. the study is questionnaire-based, and uses standardized quality of life assessment tools.

retinoblastoma is the most common eye tumor of children. it can present in one eye (unilateral) or in both eyes (bilateral). the bilateral form is always hereditary. retinoblastoma is a highly curable tumor. using a combination of surgery, chemotherapy, radiation and local treatment modalities to the eye, over 98% of patients are cured. this means that most children diagnosed with retinoblastoma will become long-term survivors. the use of surgery (taking out one eye), chemotherapy, and radiation may be associated with long term side-effects, some of which may have significant impact on the quality of life of the child. in addition, in case where the disease is hereditary, additional psychological issues arise. the aim of our study is to assess, in a comprehensive and standardized fashion, the long term quality of life in children who were treated for retinoblastoma, and who are currently alive and well. the assessment will include the use of questionnaires that assess quality of life, as well as participation in age-appropriate activities. each child, and his/her parent, will be interviewed and the questionnaires completed. the process will take about one hour for each child. no risk or discomfort to the child is involved.

Eligibility criteria:
inclusion criteria: * past treatment for retinoblastoma

Keywords: retinoblastoma quality of life
impact of dialysis modality on coagulation and platelet function

Conditions: Renal Replacement Therapy

Summary: the investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients

an prospective observational study will be conducted to confirm the impact of two dialysis modalitites on coagulation and platelet function in critically ill patients requiring renal replacement therapy using laboratory test, multiplate and rotem.

Eligibility criteria:
inclusion criteria: • critically ill adult patients in surgical intensive care unit who require renal replacement therapy exclusion criteria: * patients treated with anti-coagulation therapy due to thrombosis/embolism * patients who take anti-platelet drug due to cardiac or cerebrovascular diseased * patients treated with pharmacological prophylaxis of deep vein thrombosis * patients who received blood products within 24 hours of dialysis initiation * patients who do not want life-sustaining care including renal replacement therapy
comparative outcomes of endoscopic and open carpal tunnel release with neurotrophic supplementation in severe carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: this study addresses the pressing clinical question of optimizing surgical and pharmacological interventions for severe carpal tunnel syndrome (cts), a prevalent and debilitating condition caused by median nerve compression. previous research has established the efficacy of open carpal tunnel release (octr) and endoscopic carpal tunnel release (ectr); however, the role of neurotrophic supplementation in enhancing surgical outcomes has yet to be fully elucidated. using a prospective clinical approach involving 497 patients, we evaluated the comparative outcomes of ectr and octr with or without neurotrophic supplementation. key findings demonstrate that ectr, particularly when combined with neurotrophic agents, facilitates faster recovery and greater improvements in sensory nerve conduction velocity (vcs) and visual analog scale (vas) scores, with reduced complication rates compared to octr


Eligibility criteria:
inclusion criteria: * clinically and electromyographically confirmed severe cts (scv \< 35 m/s) * experienced persistent symptoms unresponsive to conservative treatments for at least six months exclusion criteria: * mild or moderate cts * concomitant neuropathies * previous carpal tunnel surgeries * contraindications to neurotrophic supplementation
abdominopelvic cancer prehabilitation

Conditions: Prehabilitation; Cancer of Colon; Cancer of Rectum; Cancer, Ovarian

Summary: the main objective of this research is to determine the effectiveness of a prehabilitation consultation in self-care and physical exercise aimed at patients diagnosed with abdominopelvic cancer with initial surgical indication as part of their therapeutic plan.


Eligibility criteria:
inclusion criteria: * majority (greater than or equal to 18 years). * diagnosis of abdominopelvic cancer and initial surgical indication as part of its therapeutic plan from the general surgery services of the general university hospital of castellón. * ability to give informed consent. exclusion criteria: * inability to understand the information provided or insufficient knowledge of the spanish language. * inability to carry out the scheduled intervention according to the physician's criteria. * neoadjuvant treatment to colorectal surgery.

Keywords: selfcare fisical exercice prehabilitation
baracle tab. ® versus baraclude tab.® for patients with hbeag chronic hepatitis b

Conditions: HBeAg-Positive Chronic Hepatitis B

Summary: this is a multicenter, double blind, active-controlled, randomized, parallel group study to demonstrate the anti-viral activity and safety of baracle tab. and baraclude tab. for patients with hbeag chronic hepatitis b. the subject will receive two tablets daily for 48 days.


Eligibility criteria:
inclusion criteria: * subjects with hbeag chronic hepatitis b for at least six months starting from the screening visit * subjects with hbsag-positive diagnosed at the screening visit * subjects with hbeag-positive or hbeag-negative diagnosed at the screening visit * for those who were diagnosed hbeag-positive, hbv dna level should be equal or more than 1x10\^5 copies/ml * for those who were diagnosed hbeag-negative, hbv dna level should be equal or more than 1x10\^5 copies/ml * subjects who were not administrated any anti-viral agents including interferon or pegylated interferon exclusion criteria: * subjects with hcv, hdv or hiv * subjects with decompensated liver disease who have more than 2.5mg/dl of total bilirubin, longer than 3 seconds of prothrombin time, less than 30g/l of serum albumin * with medical history of hemorrhage, hepatic encephalopathy, or dyshepatia due to ascites, jaundice, varicose vein * less than 50ml/min of creatinine clearance diagnosed at the screening visit * more than 50 ng/ml of alpha-fetoprotein at the screening visit * involved in other studies
endovascular denervation for the treatment of patients with peripheral arterial disease

Conditions: PAD

Summary: sympathetic overactivity partly promotes the development of peripheral artery disease which mainly leads to ischemia of the lower limbs. endovascular arterial denervation (ed) is a minimally invasive technique which could deliver radiofrequency energy by a multi-electrode catheter to the lower limb artery to restore sympathetic activity. the purpose of this study is to evaluate the effects of multi-electrode radiofrequency ablation system on lower limb ischemia with pad.

peripheral arterial disease(pad) show insufficient blood supply of diseased limbs, which causes intermittent claudication of lower limbs, reduced skin temperature, pain, and chronic progressive disease that still produces ulcer or necrosis. some clinical studies have shown sympathetic overactivity in the lower arterial ischemic disease. the multi-electrode radiofrequency ablation system can significantly reduce the excitability of sympathetic nerve, restore the normal response of sympathetic nerve, relieve the pain and discomfort of patients, effectively improve the symptoms of lower limb ischemia, and improve the quality of life of patients.

Eligibility criteria:
inclusion criteria: 1. eligible subjects aged 18-75 years, 2. clinically confirmed pad patients in rutherford category ii-vi. exclusion criteria: 1. thrombolytic therapy performed within 30 days, 2. patients who had undergone vascular bypass surgery before this study, 3. allergy or contraindication of antiplatelet drugs, anticoagulants, thrombolytic drugs and contrast agents, 4. patients with obvious bleeding tendency, coagulation dysfunction, hypercoagulability and blood system diseases, 5. serious liver and kidney diseases, 6. history of hemorrhagic stroke within the last 1 month or ischemic stroke or transient ischemic attack within 2 weeks, 7. pacemaker implants, 8. patients who are pregnant, breast-feeding or planning pregnancy, 9. expected survival \< 24 months.
effect of aprotinin on transfusion requirements and blood loss in patients undergoing elective primary total hip replacement

Conditions: Blood Loss, Surgical

Summary: the purpose of this study is to assess if aprotinin (bay a0128), given intravenously during surgery, is safe and can help reduce the amount of bleeding and the need for a blood transfusion during hip replacement surgery. patients undergoing major surgery are at risk for significant blood loss. because of this, there is a need for drugs that will help slow the amount of bleeding during surgery.


Eligibility criteria:
inclusion criteria: * subjects requiring elective primary total hip replacement surgery * documented, signed, dated informed consent obtained prior to any study specific procedures being performed exclusion criteria: * subjects with previous exposure to aprotinin in the last 6 months. if the subject has undergone cardiac surgery in the last 6 months, all attempts should be made to ascertain if aprotinin was administered during cardiac surgery. if no records are available, subject should be excluded. if during cardiac surgery in the last 6 months, there is a record of aprotinin administration, subject should be excluded * subjects with a known or suspected allergy to aprotinin - subjects with impaired renal function (serum creatinine \> 3.5 mg/dl or 309 micromoles/liter) * subjects with a history of bleeding diathesis or known coagulation factor deficiency * subjects with failure of a major organ system or any active significant medical illness that in the opinion of the investigator is likely to affect the subject's ability to complete the study or precludes the subject's participation in the study * subjects who refuse to receive allogenic blood products for religious or other reasons

Keywords: transfusion requirements hip replacement surgery prevention of blood loss bloodloss