Kornimate/medical-research-clean huggingface dataset:
spinal cord injury: impact on sensory, motor, behavioral and cognitive functions

Conditions: Spinal Cord Injury

Summary: spinal cord injury (sci) causes a variety of sensory-motor deficits and neuropsychological consequences. magnetic resonance imaging (mri) reveals a reduction in the volume of the somato-sensory and motor cortices, as well as atrophy in the white matter bundles. in addition, disturbances in cerebral activity are observed in several areas, notably the motor cortex and the prefrontal cortex. the aim of this study is to understand the evolution of brain function after sci in comparison with a control group of healthy volunteers. we distinguish between patients with incomplete sensorimotor deficits (asia b,c,d) and complete sensorimotor deficits (asia a). both patient groups will have a multimodal assessment at 1 week, 3 months and 12 months after sci with mri and neuropsychological tests. the group of healthy volunteers will only perform one mri.

lesions of the spinal cord induce sensory-motor deficits and have various neuropsychological effects. mri shows a reduction in the volume of the somatosensory and motor cortices, as well as atrophy of the white matter bundles. disturbances in brain activity are observed in several critical areas. patients may experience cognitive impairment and an increased risk of depression and anxiety. although deep brain stimulation and transcranial magnetic stimulation have shown positive effects, the efficacy of these treatments remains limited, partly due to insufficient understanding of post-sci brain changes. the cognitive and behavioral consequences of spinal cord injury are poorly understood and mainly treated by symptomatic therapies, which are often ineffective and may have side effects. a better understanding of brain networks and their plasticity after spinal cord injury could facilitate the development of targeted therapies, such as cortical or deep basal ganglia stimulation.

Eligibility criteria:
inclusion criteria: * adults aged 18 to 80 * informed consent * patient with mct in the previous week * clinical neurological examination demonstrating a sensory-motor deficit (the severity of which will define the group to which the patient belongs) associated with mct. exclusion criteria: * impossibility of following the patient during the study period * consent not obtained (adults, non-emancipated minors, persons unable to give consent, research carried out in emergency situations, etc.), * not affiliated to a social security scheme, * persons under court protection, * other life-threatening systemic impairment, * prior cognitive impairment, * contraindication to mri (pacemaker, metallic foreign body, etc.).

Keywords: spinal cord injury fmri dti mri diffusion tensor imaging
transcranial direct current stimulation (tdcs) improves functional outcomes in acute stroke patients

Conditions: Stroke, Acute

Summary: acute stroke patient will undergo one month (20 sessions) of physical therapy and anodal tdcs. patients will undergo functional outcomes measured at 48h post onset, 7,14,21,28 days, 3 and 6 months and one year post onset.

recruitment : patients with acute stroke (24-48h after stroke) who have upper and / or lower sensorimotor deficits • treatment : after being selected according to the inclusion and exclusion criteria of this study, patients will be randomized and placed in one of two groups: placebo (p) or transcranial anodic stimulation (a). once placed in one of two groups, patients will all receive intensive physiotherapy for functional improvement in order to increase motor, postural and motor control. this physiotherapy will be established 5 times a week (monday to friday). in addition to physiotherapy, the patient will have electrodes placed on his head, attached via a system of straps, to deliver either a continuous current (a) or no current (p) and at a rate of 5 times per week for 4 weeks. neither the physiotherapist nor the patient will know what treatment he will have received. • evaluations and measurements: patients will be required to perform functional tests of the upper limb (wolf motor function test (wmft)), filmed and timed, a test of spasticity (tardieu) as well as to answer certain questionnaires concerning their perception of the evolution of the disease and their disability (stroke impact scale, barthel index), their emotional state (hads), if they have experienced side effects, sensitivity test with monofilaments or semmes and weinstein test, the fugl meyer, the timed up and go, the test of 10m, the four step square test, the berg balance scale, the postural assessment scale and the trunk impairment scale. these evaluations will take place at day 0 (corresponding to the first day after the 48h of strict bedtime), day 7, 15, 30, 90, 6 months and 1 year. they will be done in two stages, on two successive days, so as not to exhaust the patient.

Eligibility criteria:
inclusion criteria: * woman or man * between 18 and 80 years old * first ever stroke * capable of signing the consent form exclusion criteria: * one on the tsst (in high and relatively high risk sections) * previous neurological or orthopedic pathologies affecting limbs * cognitive deficits

Keywords: tdcs wmft semmes weinstein acute stroke
hemostatic compression patterns after transradial coronary intervention

Conditions: Coronary Disease

Summary: the purpose of the study is to investigate the protective effects of short term tr band compression on transradial coronary occlusion after transradial coronary intervention.

radial artery occlusion (rao), an infrequent but serious complication after transradial coronary intervention (tri), prevents subsequent use of the same radial artery for coronary angiography and intervention. comparing to the overseas counterparts, most chinese medical workers put more emphasis on prevention of postoperative puncture site bleeding, so longer compression hemostasis time is applied but this prolonged compression may underestimate or even ignore an increasing risk of rao. therefore, this study intends to compare short term tr band compression and the routine long term one on transradial coronary occlusion after transradial coronary intervention. participants allocated to the control group will receive a routine long term postoperative puncture site compression via tr band. in control group, tr band deflation is commenced at the 2nd hour with successive 5 ml air released at 2 hours intervals until the bladder was empty at the 6th hour, and the tr band is removed at the 24th hour. participants allocated to the experimental group will receive a short term postoperative puncture site compression via tr band. in experimental group, tr band deflation is commenced at the 1st hour with 3 ml air released, and at the 2nd hour with 5ml, and at the 3rd hour with the remainder air in the bladder, and the tr band is removed at the 12th hour. at the 24th hour, rao incidence, postoperative puncture site bleeding incidence and patient comfort level will be evaluated.

Eligibility criteria:
inclusion criteria: * patients 18 years or older * patients who received tri for the first time exclusion criteria: * failure to puncture the radial artery in 1 attempt * inaccessible radial arteries because of anatomic variations, such as hypoplastic radial arteries and radioulnar loop, which can be confirmed by radial artery angiography before the tri * patients who had previous radial procedure * patients who were receiving iib/iiia receptor antagonist treatment

Keywords: coronary disease radial artery occlusion transradial coronary intervention
bk virus infection (viremia) natural history in renal transplant recipients

Conditions: BK Virus (BKV) Viremia

Summary: the objectives of this study is to establish the natural history of bk virus viremia and other possible opportunistic viral pathogens in renal transplants recipients.

this is a natural history study in renal or renal-pancreas transplant recipients. in an effort to capture patients early in the course of an evolving bk virus infection and avoid patients who have already developed evidence of bkv-induced nephropathy (bkvn), this protocol will emphasize the initiation of screening in the early post-transplant period. patients who have undergone renal or renal/pancreas transplantation within 4 weeks, but not more than 90 day previously, will be asked to participate and then consented to be enrolled in a natural history-surveillance period for up to approximately 24 months. participants enrolled in this study will provide valuable natural history data regarding bkv viremia, and potentially other viral pathogen, in the post-renal transplant period. participants will provide blood samples to undergo measurement for plasma bkv dna by pcr approximately every 6 weeks, to be resulted in real time at the uab diagnostic virology laboratory at uab.

Eligibility criteria:
inclusion criteria: renal or renal-pancreas transplant patients who are within 4 weeks and not more than 90 days post-transplant with or without qualifying bkv viremia age greater than or equal to 18 years; provides written informed consent. exclusion criteria: evidence of proven or suspected bkvn by clinical or pathologic diagnostic criteria loss of renal graft function initiation of chronic dialysis

Keywords: bk virus viremia renal transplant other viral pathogens
effects of bis closed loop target controlled infusion on perioperative inflammatory response and prognosis of elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer

Conditions: The Effect of BIS Closed-loop Target Control on Postoperative Operation

Summary: the purpose of this study is to find the elderly patients with laparoscopic gastric cancer radical is suitable the bis closed round target control level of anesthesia depth of sedation, can decrease the elderly laparoscopic gastric cancer radical surgery in patients with perioperative inflammatory reaction, and reduce the incidence of perioperative pulmonary complications such as, for elderly patients with gastric cancer radical perioperative inflammation control to provide the reference and provide guidance for clinical anesthesia work.

in this study, elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer were randomly divided into bis closed circle target controlled infusion (bis) 55 group and 45 group, and the levels of perioperative inflammatory response indicators il-6, tnf-α and il-10 at different depths of anesthesia and sedation were recorded. the duration of stay in anesthesia recovery room, quality of recovery, postoperative pain and postoperative pulmonary complications were observed. objective to evaluate the feasibility of bis closed loop target controlled infusion in elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer. perioperative period is a process of intense stress response, which is mainly manifested by the production and aggregation of inflammatory factors, which adversely affect multiple organs such as brain, heart and lung, and is an important risk factor for increasing postoperative complications and postoperative mortality . perioperative inflammatory response status has a clear relationship with postoperative recovery of patients, and perioperative anesthesia and sedation depth management and precision anesthesia is one of the most critical links to control the stress response, and appropriate anesthesia and sedation depth control and stress regulation can significantly improve the prognosis of patients . how to reduce the adverse effects of perioperative stress response on patients has been the focus of research and attention in recent years.

Eligibility criteria:
inclusion criteria: age 65 or above asa-pstype i or ii both male and female laparoscopic radical gastrectomy for gastric cancer exclusion criteria: the patient had abnormal liver, kidney and other important organs before surgery the patient has chronic pain patients with neurological or mental disorders long-term use of sedation, painkillers and antipsychotic drugs the patient has contraindications for opioid use

Keywords: bis closed-loop target controlled infusion sedation deep laparoscopic radical gastrectomy elderly patients
study of attentional disorders in patients suffering from idiopathic generalized epilepsy.

Conditions: Idiopathic Generalized Epilepsy

Summary: attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). we aim to describe attentional and executive function disorder in ige thanks to the epitrack scale, validated in this specific population. our secondary objective is to study the dynamic of cortical activity during an attentional task (the ant), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.


Eligibility criteria:
inclusion criteria: * idiopathic generalized epilepsy followed-up during at least 2 years * at least one antiepileptic drug medication * no cognitive decline (moca score \>26) * absence of concomitant pathology that could interfere with the purpose of the study. * be affiliated to the social security system * have signed an informed consent exclusion criteria: * pregnancy * not able to give consent (article 1121-8 of the csp) vulnerable person being deprived of liberty by judicial or administrative decision (article l 1121-6 of the csp) have a high probability of not respecting the protocol or of abandoning the study

Keywords: attention epilepsy connectivity eeg
a study of gdc-0927 in postmenopausal women with locally advanced or metastatic estrogen receptor positive breast cancer

Conditions: Breast Cancer

Summary: this is an open-label, dose-finding, safety, pharmacokinetics (pk), and evidence-of-activity study of gdc-0927 in postmenopausal women with locally advanced or metastatic estrogen receptor positive (er+) human epidermal growth factor receptor 2 (her2) breast cancer. the study will be conducted in two parts: dose escalation and dose expansion. during dose escalation, gdc-0927 will be administered orally as a single dose on day -7 for pk evaluation during the lead-in period. depending on safety and tolerability, participants will be assigned sequentially to escalating doses of gdc-0927 using standard 3+3 design. during dose expansion, there will be no pk week lead-in period. all participants will be treated until disease progression, unacceptable toxicity, participant withdrawal of consent or study termination.


Eligibility criteria:
inclusion criteria: * histologically or cytologically proven diagnosis of adenocarcinoma of the breast with evidence of either locally recurrent disease not amenable to resection or radiation therapy with curative intent, or metastatic disease, both progressing after at least 6 months of hormonal therapy for er+ breast cancer * er-positive tumor, her2-negative breast cancer * no prior treatment with gdc-0810 (allowed only during dose expansion stage) * no more than 2 prior chemotherapies in the advanced or metastatic setting * at least 2 months must have elapsed from the use of tamoxifen * at least 6 months must have elapsed from the use of fulvestrant * at least 2 weeks must have elapsed from the use of any other endocrine therapy * at least 3 weeks must have elapsed from the use of any chemotherapy * females, 18 years of age or older * postmenopausal status as defined by the protocol * eastern cooperative oncology group (ecog) performance status less than or equal to (\</=) 2 (for dose-escalation part) and 0 or 1 (for dose-expansion part) * adequate organ function exclusion criteria: * untreated or symptomatic brain metastases * current treatment with any systemic anti-cancer therapies for advanced disease or any systemic experimental treatment on another clinical trial * any of the following within 12 months prior to enrollment: myocardial infarction, severe/unstable angina, ongoing cardiac dysrhythmias of grade greater than or equal to (\>/=) 2, atrial fibrillation of any grade, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, or cerebrovascular accident including transient ischemic attack * active inflammatory bowel disease or chronic diarrhea, short bowel syndrome, or upper gastrointestinal surgery including gastric resection * known human immunodeficiency virus (hiv) infection * major surgery within 4 weeks prior to enrollment * radiation therapy within 2 weeks prior to enrollment
the application of probe-based confocal laser endomicroscopy in the diagnosis of deep endometriosis

Conditions: Bowel Endometriosis

Summary: endometriosis is defined as the presence of endometrial glands and stroma outside of the uterus.endometriosis affects 5%-15% of women in the reproductive age. deep endometriosis is mostly defined as a single endometrial nodule, located in the vesico-uterine fold or close to the distal 20 cm of the large bowel. current guidelines recommends that laparoscopy with histology should be done to diagnose endometriosis. probe-based confocal laser endomicroscopy (pcle) has been used as a gi tract endoscopy additive tool in recent years, providing in-vivo cellular-level imaging, a concept known as "optical biopsy". considering the rectal bleeding that occurs in patients suffering from bowel endometriosis, usually with a normal mucosa seen at standard endoscopy (personal data), we hypothesized that there might be histological architectural changes in the vessels or the mucosa/sub mucosa in bowel endometriosis.

endometriosis is defined as the presence of endometrial glands and stroma outside of the uterus, most commonly over the ovaries, fallopian tubes, bladder, recto-sigmoid colon and the uterine myometrium.endometriosis affects 5%-15% of women in the reproductive age causing pelvic or abdominal pain, infertility and occasionally rectal bleeding (if involving the bowel). deep endometriosis is mostly defined as a single endometrial nodule, usually larger than 1 cm which is located in the vesico-uterine fold or close to the distal 20 cm of the large bowel. those lesions usually infiltrate at least 5 mm into the tissue involved. the gold standard of diagnosis is histological proven endometriosis, usually obtained during explorative laparoscopy. other imaging tests that aid in the diagnosis are trans-vaginal or trans-rectal sonography (trus), mri \& ct. current guidelines recommends that laparoscopy with histology should be done to diagnose endometriosis. negative (normal) laparoscopy is highly accurate in excluding endometriosis, but a positive laparoscopy (i.e. with macroscopic findings) without biopsy has a limited value. in practice, many clinicians refrain from taking biopsies due-to the risk of bowel surgery, particularly on an un-prepared bowel. probe-based confocal laser endomicroscopy (pcle) has been used as a gi tract endoscopy additive tool in recent years, providing in-vivo cellular-level imaging, a concept known as "optical biopsy". considering the rectal bleeding that occurs in patients suffering from bowel endometriosis, usually with a normal mucosa seen at standard endoscopy (personal data), we hypothesized that there might be histological architectural changes in the vessels or the mucosa/sub mucosa in bowel endometriosis.

Eligibility criteria:
inclusion criteria: * endometriosis exclusion criteria: * unable or unwilling to give and sign an informed consent * allergy to fluorescein * colitis * critical illness * pregnancy * malignancy
liver regional oxygen saturation in preterm patent ductus arteriosus

Conditions: Patent Ductus Arteriosus; Circulation; Newborn Morbidity; Premature Birth

Summary: this study evaluates the usefulness of liver perfusion and oxygenation status using regional oxygen saturation (rso2) values obtained via near-infrared spectroscopy in assessing the hemodynamical significance of patent ductus arteriosus in preterm infants.

the usefulness of cerebral and renal regional oxygen saturation (rso2) values for assessing hemodynamically significant patent ductus arteriosus (hspda) has been described previously. meanwhile, autoregulation of the splanchnic organs' perfusion is less developed compared to the cerebral and renal system, which makes the splanchnic bed more prone to perfusion decrease and ischemia in cases of volume depletion or poor circulation. if rso2 is measure in the liver, the solid organ reflecting the splanchnic bed perfusion status, hspda may be more readily identified than when only cerebral and/or renal rso2 is monitored. this study aims to evaluate the usefulness of liver rso2 measurement in assessing the hemodynamical significance of patent ductus arteriosus in preterm infants, in comparison to cerebral and renal rso2.

Eligibility criteria:
inclusion criteria: * gestational age at birth less than 32 weeks * birthweight less than 1,500 grams exclusion criteria: * major congenital anomaly * chromosomal / genetic anomaly
reliability and validity of the tampa scale for kinesiophobia

Conditions: Hand Injuries; Forearm Injuries; Trauma

Summary: the aim of this study was to investigate the validity and reliability of the tampa scale for kinesiophobia (tsk) in patients with traumatic hand and forearm injuries. a total of 170 patients with traumatic hand-forearm injuries with a mean age of 37.57±11.85 (18-63) years were included in the study. tsk, pain catastrophizing scale (pcs) and beck anxiety inventory (bai) were applied to the patients in the first session. tampa scale for kinesiophobia was re-administered 15 days after the first session. test-retest reliability, internal consistency, and construct validity of the tsk were evaluated. in addition, exploratory factor analysis was applied.


Eligibility criteria:
inclusion criteria: * patients who had traumatic hand and forearm injuries * being 18-65 years old exclusion criteria: * patients who have neurological, orthopedic, rheumatological disease or surgery history in the relevant extremity * patients who have communication problems

Keywords: hand injuries forearm injuries kinesiophobia psychometrics
evaluation of a morning dosing of a new medicine and its effects on sleep at bedtime in subjects with primary insomnia

Conditions: Sleep Initiation and Maintenance Disorders; Insomnia

Summary: this study is designed to determine whether morning doses of gw679769, taken daily for 1 to 9 days, will promote sleep during the following night without significant post-dose thinking impairment and drowsiness in subjects with primary insomnia.


Eligibility criteria:
inclusion criteria: * difficulty going to sleep and/or staying asleep during at least the past 3 months. * insomnia must result in significant distress or impairment in functioning at home, socially or at work. * otherwise good health with no significant or unstable medical disorder including psychiatric, neurological, endocrine, heart, lung or gastrointestinal disorders, drug/alcohol abuse, cognitive impairment, cancer or chronic pain conditions such as arthritis. exclusion criteria: * history of other sleep disorders such as sleep apnea or restless leg syndrome; regular sleep habits, including bedtime between 9 pm and midnight, nightshift/rotating shift work, frequent napping or planned travel across \>2 time zones. * use to moderate use of nicotine, caffeine and alcoholic products.

Keywords: cognition primary insomnia sleep polysomnography