Kornimate/medical-research-clean huggingface dataset:
adhesive materials for continuous glucose monitoring systems

Conditions: Diabetes Mellitus

Summary: within the present study 4 different band-aid/adhesive combinations will be tested in patients with type 1 diabetes and type 2 diabetes with regard to adherence to the body and allergic potential. the study period is set to 21 days following adhesive material placement to cover the maximum expected wear-time of the novel cgm system (14 days) plus an additional seven days to ensure that adhesive material is tested for a sufficient time-period and differences in adhesion can clearly be observed.


Eligibility criteria:
inclusion criteria: * informed consent obtained after being advised of the nature of the study * male or female aged ≥18 years * type 1 diabetes for at least 6 months according to the who definition or type 2 diabetes for at least 6 months according to the who definition * body mass index (bmi) \<45 kg/m² * willing and able to wear 4 different band-aid/adhesive materials for the duration of the study and undergo all study procedures * hba1c ≤86 mmol/mol exclusion criteria: * any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject * female of childbearing potential who is pregnant, breast-feeding or intend to become pregnant or is not using adequate contraceptive methods * any mental condition rendering the subject incapable of giving his consent * subject is using any medication that significantly impacts immune response (oral steroids) * has severe medical or psychological condition(s) or chronic conditions/infections that in the opinion of the investigator would compromise the subject's safety or successful participation in the study * subject is actively enrolled in another clinical trial * known severe hypersensitivity to adhesive or skin lesions that hinder band-aid application * inability of the subject to comply with all study procedures * inability of the subject to understand the subject information * has children two years of age or younger * vulnerable patients, patients deprived from liberty and patients with a physical or mental state altered by disease, age or disability which impacts their ability to defend their interests and for which protection measures are taken ("protected majors" as per french law).
testing mild traumatic brain injury (mtbi) in diverse athletic groups

Conditions: Brain Injuries, Traumatic

Summary: study will test the use of a short virtual reality driven goggle test as a means of detecting mtbi in a diverse group of athletes


Eligibility criteria:
inclusion criteria: 1. participants from 18 - 90 years of age who participate in all amateur athletics at the university of miami to include all levels of sports whether national collegiate athletic association (ncaa) or club. initial recruitment will include high intensity sports, including but not limited to men's football, men's and women's soccer, men's and women's basketball, men's and women's volleyball, men's baseball and women's softball, and club sports to include men's and women's lacrosse, hockey, rugby, and field hockey). 2. participants from 18-90 years of age who are or have been engaged in olympic level competitions as an active participant or team member. 3. participants from 18-90 years of age who are engaged in professional sports as an active participant or formerly as a team member. initial recruitment will include all motor sports, ice and field hockey, football, soccer, basketball, and rugby. exclusion criteria: 1. history of brain injury resulting from a penetrating wound to the head. 2. presence of aphasia and/or inability to give informed consent for participation 3. history of diagnosed neuropsychiatric disorders 4. documented neurodegenerative disorders 5. prior disorders of hearing and balance including: 1. meniere's disease 2. multiple sclerosis 3. vestibular neuritis 4. vestibular schwannoma 5. sudden sensorineural hearing loss 6. cerebrovascular disorders 7. history of ear operation other than myringotomy tube in the past 8. systemic disorders: e.g. chronic renal failure, cirrhosis of the liver, etc. 9. presence of intra-cranial structural findings on imaging studies 10. prisoners

Keywords: concussion, mild traumatic brain injury
coronary microvascular dysfunction in angina patients with non-obstructive coronary artery disease (anoca-cmd)

Conditions: Angina Patients With Non-obstructive Coronary Artery Disease; Coronary Microvascular Dysfunction; Index of Microvascular Resistance

Summary: the goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (ffr) \>0.80.


Eligibility criteria:
inclusion criteria: * presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (ffr) \>0.80 exclusion criteria: 1. acute myocardial infarction 2. significant valvular heart disease 3. advanced chronic kidney disease 4. patients with significant epicardial coronary artery stenosis (\>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention 5. patients unable to provide written informed consent
weight loss interventions for black adults of faith

Conditions: Obesity-Related Malignant Neoplasm

Summary: this trial compares the effect of intermittent fasting versus continuous caloric reduction for the reduction of body weight in black adults of faith. intermittent fasting and continuous caloric reduction interventions may help black adults of faith lose weight, improve their health, and help reduce cancer risk.

primary objectives: i. partner with the first ladies of western new york (flow) to engage 10 community stakeholders from black churches in the roswell park catchment area in a four-stage process involving information gathering, discussion groups, and mock intervention delivery to create fasting word for black adults of faith. ii. implement and determine the initial comparative effectiveness of fasting word with the word to reduce body weight, and biomarkers of obesity, inflammation, insulin, and insulin resistance. secondary objectives: i. examine the interventions' effects on diet and physical activity. ii. examine participants' adherence and satisfaction with both interventions. outline: participants are randomized to 1 of 2 arms. arm i: participants receive the fasting word intermittent fasting weight loss intervention consisting of 16 small-group lessons over 1.5 hours each once a week (qw) for 2 months and then once every 2 weeks (q2w) for 4 months. arm ii: participants receive the word continuous energy restriction (cer) weight loss intervention consisting of 16 small-group lessons over 1.5 hours each qw for 2 months and then q2w for 4 months. after completion of study, participants are followed up for 30 days.

Eligibility criteria:
inclusion criteria: * african american/black * body mass index (bmi) \> 25 kg/m\^2 * associated with a participating church through membership or participation in a church activity * cleared by a primary care provider (pcp-doctor) to be a part of the study * not currently on weight loss medications * not pregnant or lactating * has not lost at least 10% of their body weight in the last 6 months * has not had bariatric surgery in the last 10 years * able to walk unassisted and continuously for 10 minutes exclusion criteria: * adults unable to consent * adults unable to complete study measures in english * individuals who are not yet adults (infants, children, teenagers) * individuals who are pregnant or lactating * adults who have had a myocardial infarction (heart attack) or stroke without medical clearance from their primary care physician to participate in the study * adults who currently have type 1 or type 2 diabetes without medical clearance from their primary care physician to participate in the study
apical support during hysterectomy for pelvic organ prolapse-nsqip analysis.

Conditions: Pelvic Organ Prolapse

Summary: this is a retrospective descriptive study using the american college of surgeon's national surgical quality improvement program® (acs nsqip®) data to determine whether gynecologic surgeons are already meeting the recently recommended best practice of supporting the vaginal apex at time of hysterectomy for pelvic organ prolapse (pop).

the prevalence of pelvic organ prolapse (pop) in the united states is estimated to be between 40-50% with an anticipated increase over the next several decades. approximately 300,000 women undergo surgeries to repair pop in the united states every year. following pelvic reconstructive surgery, recurrence rates of symptomatic prolapse range between 6-30%. our understanding of pelvic anatomy and its support has been significantly improved over recent decades, with many researchers reporting on details and mechanics previously not understood. in november 2017, the american college of obstetricians and gynecologists released a new practice bulletin outlining the current standard of care for the treatment of women with pelvic organ prolapse. in this bulletin, they state that a hysterectomy alone is not adequate treatment for pop, and further that any woman having a hysterectomy for pop should undergo a concurrent apical suspension procedure as a standard of care. the purpose of this study is to determine the proportion of patients undergoing hysterectomy for the indication of pop having concurrent apical suspension among the population whose cases are reported within the nsqip database, and who underwent hysterectomy between 2015 and 2017.

Eligibility criteria:
inclusion criteria: * underwent hysterectomy for pelvic organ prolapse, between 2015 and 2017 exclusion criteria: * age \< 18 years old * pelvic organ prolapse was not recorded in their postoperative diagnoses
bilateral essential tremor treatment with gamma knife

Conditions: Essential Tremor

Summary: combined phase ii/iii, multi-center, prospective, single-blinded trial. ten (10) patients with essential tremor who previously underwent successful and uncomplicated gk thalamotomy for essential tremor will undergo a contralateral treatment. the incidence of side effects will be determined at 3 months postoperatively, graded per the ctcae v5 and analyzed by a data safety monitoring board. upon successful review, this phase ii trial will be converted to a phase iii trial of utility that will enrol 40 additional patients. the primary outcome will be the change in quest score at 12 months postoperatively, as well as a patient-reported assessment of health utility. secondary outcomes will include objective tremor, gait and speech assessments (filmed and scored by blinded evaluators), as well as quality of life questionnaires and adverse events questionnaires. outcomes will be assessed at baseline, as well as 3, 6, 12, 24 and 36 months post-operatively.


Eligibility criteria:
inclusion criteria: * patients must be ≥ 18 years * the patient has a primary diagnosis of et or et plus confirmed by a movement disorder neurologist; * the patient previously underwent a gk thalamotomy (\> 12 months ago); * the tremor on the untreated side negatively impacts the patients' quality of life; * the patient wants treatment of the contralateral side. exclusion criteria: * clinically relevant gait and/or balance impairment (e.g. wide-based, more than 2 falls/months, wheelchair, walker, cane use); * clinically relevant speech impairment (e.g. impairment of intelligibility); * inability to comply with the follow-up schedule; * refusal of the treating physician.

Keywords: gamma knife thalamotomy tremor essential tremor dyskinesias neurologic manifestations nervous system diseases movement disorders central nervous system diseases
the effect of mindfulness-based stress reduction programme on smartphone addiction, stress and quality of life in university students

Conditions: Smartphone Addiction; Mindfulness Based Stress Reduction; Quality of Life

Summary: the aim of this observational study was to examine the effect of mindfulness-based stress reduction program on smartphone addiction, stress and quality of life in nursing students. the main question it aims to answer is: is there a significant relationship between smartphone addiction, quality of life and stress in nursing students? smartphone addiction scale will be applied and students with risky scores will be determined and pre-test will be applied to the students in the experimental group according to randomization. during an 8-week intervention period, in addition to mindfulness practices and experiential studies, experiential practices will be carried out on stress, stress management and how mindfulness is applied in daily life and interpersonal communication through the sharing of the participants.

this study was conducted to investigate mindfulness-based stress reduction in nursing students. to determine the effect of the program on smartphone addiction, stress and quality of life will be carried out for this purpose. the data obtained in the study will only be used in this study. this you will not be charged for the study and you will not receive any remuneration. information about you will be kept confidential, but officials overseeing the quality of the study, ethics will be examined if deemed necessary by committees or authorities. smartphone addiction scale was administered, students with risky scores were identified, and the students who received risky scores were identified during an 8-week intervention period. in addition to mindfulness practices and experiential work through the participants' sharing, stress, stress management and mindfulness in daily life and how it is applied in interpersonal communication will be done. after this process is over, the post-test will be applied and necessary analyzes will be made. education a follow-up test will be performed 12 weeks after the end of the study.

Eligibility criteria:
inclusion criteria: * individuals over 18 years of age, * from the highest on the smartphone addiction scale students from the beginning until the sample size is reached * no diagnosed psychiatric illness or medication not to use it, * volunteering to participate in the study * muş alparslan university at the time of the research continuing education in the department of nursing exclusion criteria: * students who did not participate in at least two group programs and

Keywords: mindfulness university students stress
pain prevalence after major craniotomy

Conditions: Pain; Craniotomy

Summary: craniotomies are generally thought to be less painful than other operations. indeed recent studies have confirmed that pain is a common problem during the postoperative phase following craniotomy.pain not only causes discomfort, but it is also associated with other potential adverse events such as increased sympathetic activity and elevated systemic blood pressure. these events in turn may contribute to increased intracranial pressure. some patients may also develop chronic pain.potent opioids have been avoided due to its potential to cause respiratory depression and risk of masking pupillary signs. as a result postoperative craniotomy pain controls are usually inadequate. in siriraj hospital, there are 500-600 craniotomy patients per year. still there are no definite guidelines for postoperative pain management in these patents due to lack of information about quality of postoperative pain control after craniotomy. objectives primary objective : - to study incidence of moderate to severe pain during first 48 hours after craniotomy. secondary objectives : * to determine risk factors for moderate to severe pain during first 48 hours after craniotomy * to evaluate side effects and complications of postoperative craniotomy pain control * to compare patient's expectation for pain management before and after surgery * to determine patient's satisfaction for postoperative pain management


Eligibility criteria:
inclusion criteria: * patient undergoing major craniotomy (supratentorial surgery and infratentorial surgery) * age \> 18 years exclusion criteria: * emergency or trauma * need postoperative ventilatory support * cannot communication * psychosis * not adherence to the treatment protocol * history of using benzodiazepine or addictive substance

Keywords: pain craniotomy
imatinib mesylate in treating patients with stage iv colorectal cancer

Conditions: Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer

Summary: phase ii trial to study the effectiveness of imatinib mesylate in treating patients who have stage iv colorectal cancer. imatinib mesylate may interfere with the growth of tumor cells by blocking certain enzymes necessary for cancer cell growth

primary objectives: i. to determine response to gleevec (imatinib mesylate) in patients with metastatic colorectal cancer and with c-kit, arg, abl, or pdgf-r expression. ii. to determine the side effects of imatinib mesylate in patients with colorectal cancer. iii. to study the biologic effects of imatinib mesylate on the c-kit and pdgf-r system and downstream signaling in metastatic colorectal cancer. outline: patients receive oral imatinib mesylate twice daily. treatment continues for 8 weeks in the absence of disease progression or unacceptable toxicity. patients with stable disease or better continue therapy until disease progression or 1 year after complete response.

Eligibility criteria:
inclusion criteria: * histologically confirmed stage iv colorectal cancer * arg, kit (cd117), or pdgf-r expression (1+ in 20% of cells) in the tumor or microvasculature * at least one unidimensionally measurable lesion * at least 10 mm by spiral ct scan * no known brain metastases * performance status - ecog 0-2 * performance status - karnofsky 60-100% * at least 12 weeks * granulocyte count at least 1,500/mm\^3 * platelet count at least 100,000/mm\^3 * bilirubin no greater than 2.0 mg/dl * ast/alt less than 2.5 times upper limit of normal * creatinine no greater than 2.0 mg/ml * no symptomatic congestive heart failure * no unstable angina pectoris * no cardiac arrhythmia * not pregnant or nursing * negative pregnancy test * fertile patients must use effective barrier contraception during and for 3 months after study participation * no other malignancy within the past 3 years except non-melanoma skin cancer or carcinoma in situ of the cervix * no concurrent uncontrolled illness * no ongoing or active infection * no psychiatric illness or social situation that would preclude study compliance * more than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered * more than 4 weeks since prior radiotherapy and recovered * more than 3 weeks since prior surgery (excluding diagnostic biopsy) * no other concurrent investigational agents * no concurrent therapeutic doses of anticoagulants (e.g., warfarin) * no concurrent grapefruit * no concurrent combination antiretroviral therapy for hiv-positive patients
vaginal birth after caesarean section - effect on maternal psychosocial function

Conditions: Pregnancy; Cesarean Section; Uterine Rupture

Summary: the incidence of caesarean section has reached 15-20% in most developed countries. encouraging vaginal birth after caesareans section (vbac) has been considered a key component of a strategy to reduce the caesarean section rate. most medical literature has focused on the efficacy of vbac in reducing the caesarean section rate and the physical safety of successful vbac. however, 30%-40% of these women fail to achieve a vaginal delivery. little is known about how the uncertainty of labour outcome and a failed vbac impact on the psychosocial function of these women. we propose to study a cohort of women with a prior caesarean section and presenting with a subsequent pregnancy for care. after consent and recruitment, these subjects will be randomly assigned to have a repeat caesarean section or vbac. the medical outcomes, overall satisfaction of the subjects with the care they received, and the short-term psychosocial function of these subjects will be studied. the result of this study will provide important information that would be useful in assisting women to decide the mode of delivery after a prior caesarean section.


Eligibility criteria:
inclusion criteria: all women who: * have one prior caesarean section * no prior vaginal delivery and * agree for either vaginal delivery or elective caesarean section

Keywords: pregnancy women with a scarred uterus due to previous caesarean section
observed pharmacokinetic of piperacillin/tazobactam compared to amikacin in icu

Conditions: Septic Shock; Sepsis; Sepsis Syndrome

Summary: the pharmacokinetics of antimicrobials is profoundly modified in intensive care unit (icu) patients. to adapt the treatment, it is recommended to measure blood levels of antibiotics. some antibiotics, such as amikacin, are easy to monitor, while for other molecules, such as piperacillin/tazobactam, the drug monitoring is more difficult to obtain. these two molecules have similar physicochemical characteristics (hydrophilicity) and therefore have closed pharmacokinetic properties. optima is a study aiming at criteria will be used to judge whether the pharmacokinetic (pk) parameters of amikacin are predictive of those of piperacillin and tazobactam.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old * patient hospitalized in the critical care department of the lyon-sud hospital centre * patient with a sepsis or a severe sepsis table defined by the latest international recommendations * patient to be treated by the amikacin + piperacillin/tazobactam association * patient affiliated to a social security system, having agreed to participate in the study exclusion criteria: * patient with a known history of hypersensitivity or contraindication to amikacin, piperacillin or tazobactam * patient known to have previously received piperacillin/tazobactam or amikacin combination before inclusion * patient treated at the time of inclusion with dialysis techniques