Kornimate/medical-research-clean huggingface dataset:
pegfilgrastim on day +3 compared to day +1 after salvage chemotherapy for patients with refractory or relapsed aggressive lymphoma

Conditions: Lymphoma; Neutropenia

Summary: granulocyte colony stimulating factors (gcsfs) stimulate the level of white blood cells, specifically neutrophils. gcsf support for patients receiving chemotherapy was shown to decrease the rate of fever during low neutrophil count (neutropenia), and in some cancer types may decrease mortality. pegfilgrastim is a pegylated form of the gcsf named filgrastim. pegfilgrastim is used to stimulate bone marrow to produce more neutrophils to fight infection in patients undergoing chemotherapy. it has a much longer half-life than the parent filgrastim. it is removed from the body within the neutrophils. according to the american society of clinical oncology 2006 guidelines pegfilgrastim should be given 24 hours after the completion of chemotherapy i.e.before neutrophil count starts to drop. therefore it is cleared before and after neutropenia. comparative low quality studies suggest that deferring pegfilgrastim delivery until neutrophil counts start dropping may result in improved its efficacy. this was further tested in a few small randomized controlled trials (high quality studies, considered the "gold standard" of studies) in different settings (including first chemotherapy for lymphoma, and solid cancer) with inconsistent results. pegfilgrastim (given 24 hours after completion of chemotherapy) is a standard part of any salvage chemotherapy for patient with refractory or relapsed aggressive lymphoma. the investigators plan a randomized controlled trial comparing the efficacy of pegfilgrastim given 72 hours (day +3) vs. 24 hours (day +1) after completion of salvage chemotherapy in patients with refractory or relapsed aggressive lymphoma. the investigators will evaluate whether that change of pegfilgrastim schedule affects the risk of fever during neutropenia, neutrophil count, length of hospitalization, mortality, and safety.


Eligibility criteria:
inclusion criteria: adult patients (age 18 years or above) * refractory or relapsed aggressive lymphoma, including hodgkin's and non-hodgkin's lymphoma * candidate for salvage chemotherapy. salvage chemotherapy includes one of the following regimens: ifosfamide, etoposide, vincristine (ice), cisplatin, cytarabine, and dexamethasone (dhap), etoposide, methylprednisolone, cytarabine, cisplatin (eshap). chemotherapy dose reduction will be allowed. * chemotherapy with or without immunotherapy * therapy in hospital or at the outpatient clinic exclusion criteria: * indolent lymphoma; we will exclude patients with transformed lymphoma. * treatment with gcsfs for the primary disease (e.g. aplastic anemia, mds). * uncontrolled infection * pregnant women

Keywords: lymphoma neutropenia pegfilgrastim
developing the precision nursing education program to young colorectal cancer survivors

Conditions: Depression

Summary: this study is aimed to demonstrate the long-term effectiveness of 8-week precision nursing education program through the e-flipped classroom model for ycc survivors and provide a compliant strategy to improve quality of life and emotional status of these patients.

background: in recent years, there has been an increase in case number of patients with young colon cancer (ycc). after curative treatment, ycc survivors have more opportunities to meet physical, social and economic burdens. furthermore, ycc survivors may suffer poor quality of life and depression symptoms related to disease treatments and specific post-treatment care intervention is in unmet need. objective: the precision nursing education program will be developed through the eflipped classroom model, including the care of physical symptom based on the patients' needs, qigong exercise, and mindfulness training. to evaluate the effect of these interventions, the questionnaire of the quality of life of ycc survivors will be employed. method: a randomized controlled trial containing 110 patients aged between 20 and 50 years old will be conducted. after completion of curative operation and adjuvant treatments, the subjects will be randomly assigned to a control group, in which routine nursing education care will be provided, and an intervention group, in which 8-week precision nursing education program through the e-flipped classroom model will be applied. the outcome measures include eortc qlq-c30, eortc qlq-cr29, bdi depression scale, constructed meaning scale and ffmq. the time-points of outcome measures include pre-intervention, post-intervention (at the end of the intervention), and 3, 6 and 9 months after the end of intervention. univariate analyses will be performed to examine the intervention outcomes among basic characteristics of subjects. correlation analyses will be performed to investigate the relationships between intervention outcomes and different variables. comparisons of mean scores in the dependent variables between the experimental group and control group over the five time-points will be used in the generalization of estimating equation models. contribution: this study is aimed to demonstrate the long-term effectiveness of 8- week precision nursing education program through the e-flipped classroom model for ycc survivors and provide a compliant strategy to improve quality of life and emotional status of these patients.

Eligibility criteria:
inclusion criteria: * survivor was diagnosed as colon, rectal, colorectal, or/and anal cancer * aged at least 20 years * have had completed cancer treatments within the five years prior to enrolling in the study. * agree and obtain written consent * could using the online media(ex: zoom or google meet..) to attend intervention course exclusion criteria: * diagnosed with stage iv cancer * had a recurrence of crc cancer * had the other type cancer diagnosis * now are undering cancer treatment

Keywords: depression young colorectal cancer survivors precision nursing education
a primary care, ehr- based strategy to promote safe and appropriate drug use

Conditions: Diabetes Mellitus Type I; Diabetes Mellitus Type II

Summary: this study seeks to evaluate a low-literacy strategy in a primary health care setting for promoting safe and effective prescription medication use among english and spanish-speaking patients with diabetes. the investigators hypothesize that in comparison with patients receiving standard care, the patients that received the electronic health record (ehr) strategy will 1) demonstrate better understanding of how to safely dose out their medication regimen; 2) have fewer discrepancies in their medication lists; 3) take their medication regimen more efficiently; 4) have greater adherence to their medication regimen.

the strategy takes advantage of health information technology to assist patients with medication therapy management (mtm) tasks, intervening with a set of low-literacy mtm printed tools triggered by the electronic health record (ehr) in a primary health care clinic. patients at the university of illinois at chicago (uic) medicine clinic who are randomized to the intervention arm will be given three printed tools, one when they check in to the clinic and the other two when they check out. the electronic health record (ehr) triggers the printing of these tools, and the receptionist hands them to the patient. patients receive either english or spanish language materials depending on the preference determined in the screening process and stored in their ehr. specific aims 1. refine and field test an ehr strategy for generating and distributing low literacy prescription information for english and spanish-speaking patients 2. assess the process of the ehr intervention and its fidelity for providing prescription information for patients at the point of prescribing and dispensing medications. 3. evaluate the effectiveness of the ehr strategy to improve medication understanding, reconciliation, regimen consolidation, and adherence compared to standard care. in addition, we will be powered to also investigate our strategy's impact on intermediary clinical outcomes including systolic blood pressure, hba1c, and ldl cholesterol.

Eligibility criteria:
inclusion criteria: * 18-years old or older; * have a diagnosis of diabetes mellitus either by icd-billing codes or indicative medications; * are prescribed at least (3) chronic condition medications according to the ehr medication list; * are english or spanish-speaking; * have no imminent intention to move or change clinics within the next year; * score 4 or higher on the six-question screener based on the mini-mental status exam; * are primarily responsible for administering their own medications; * prescribed a new chronic condition medication (including refills, and change in titrations) during their clinic visit and day. exclusion criteria: * under age of 18 years-old; * does not speak english or spanish; * dependent on assistance for medication administration; * scored less than 4 on the six-question screener; * not prescribed a new medication or changed medication at clinical appointment;

Keywords: diabetes
compassionate use program with lacosamide in patients with partial-onset or generalized tonic-clonic seizures

Conditions: Epilepsies, Partial

Summary: the objective of this compassionate use program (cup) is to provide continued access to lacosamide (lcm) for monotherapy use for patients who were receiving lcm in sp0993 and sp0994 at the time of study unblinding and close of sp0994, and who benefited from the treatment per investigator assessment.


Eligibility criteria:
inclusion criteria: * patient has completed the termination visit of sp0994 and has been treated with lacosamide (lcm) monotherapy * patient is expected to benefit from participation in the compassionate use program (cup) with lcm monotherapy, in the opinion of the treating physician * patient is willing and able to comply with all program requirements * patient is informed of the details of this cup, is given ample time and opportunity to ask questions and consider his/her participation in this cup, and the patient or the legally authorized representative (lar) has provided verbal consent to participate, and, if applicable to local regulations, has given written informed consent exclusion criteria: * patient is receiving any investigational drugs or using any experimental devices in addition to lcm * for countries where lcm is reimbursed: patient requires another anti-epileptic drug (aed) for the treatment of seizures for countries where lcm is not reimbursed (or conditionally reimbursed: belgium, australia e.g.): patient requires another aed for the treatment of seizures and qualifies for commercial lcm (and lcm is being reimbursed) * patient experienced emergence of a seizure type other than partial-onset or generalized tonic-clonic seizures, or occurrence of status epilepticus * patient developed second- or third-degree atrioventricular (av) block or another clinically relevant change in medical condition (or electrocardiogram (ecg) or laboratory parameter) * patient having liver function test (lft) results of transaminases (aspartate aminotransferase \[ast\] and/or alanine aminotransferase \[alt\]) ≥3×uln to \<5×upper limit of normal (uln) * patient has actual suicidal ideation or behavior * patient is experiencing an ongoing serious adverse event (sae) and there is no expected benefit for him/her to continue on lcm treatment * female patient who is pregnant or nursing, and/or a woman of childbearing potential who is not surgically sterile, 2 year postmenopausal or does not practice one highly effective method of contraception (according to ich guidance defined as those that result in a failure rate of less than 1 % per year when used consistently and correctly), unless sexually abstinent, for the duration of the study * patient was treated with carbamazepine controlled release (cbz-cr) in sp0994
relationship between neck posture and stiffness of head and neck muscles, pain and proprioception in desk workers

Conditions: Work-Related Condition; Musculoskeletal Health

Summary: in our study, posture in desk workers; it aims to evaluate the relationship between cervical range of motion, proprioception, muscle stiffness, posture and pain.

one hundred twelve participants were included in the study. cervical range of motion and cervical proprioception were evaluated with a cervical range of motion (crom) goniometer device, and muscle stiffness was evaluated with myotonometer device. pain was evaluated with visual analog scale, and migraine disability assessment scale (midas) and neck disability index. posture was evaluated with posture screen mobile application.

Eligibility criteria:
inclusion criteria: * volunteer individuals aged 18-65 * individuals using a computer in a sitting position at a desk exclusion criteria: * individuals who have had serious traumatic injuries to the head, neck and shoulder area * individuals who have undergone any surgery on the head, neck and shoulder region * individuals with any anomaly in the head, neck and shoulder region

Keywords: proprioception pain neck posture neck muscle stiffness desk worker
cannabis tolerance break resource study: t-break guide

Conditions: Cannabis Use; Tolerance; Cannabis Withdrawal

Summary: the purpose of this pilot study is to conduct research into the value of using the t-break guide for assisting people taking a tolerance break from cannabis. the hope is that this initial research will yield some insights and benchmarks into the guide's efficacy, and provide a foundation for a later randomized control study. the following are some key research questions: 1. how did participants use the guide? (eg: daily; read once; 'a la carte') 2. how did using the guide increase fidelity to tolerance break (starting, continuing, completing a break)? 3. did using the guide yield any benefits beyond tolerance break fidelity? (eg: insight into patterns of use)

the pilot study used a pretest-posttest design in which participants completed a baseline survey and were asked to attempt a 21-day period of cannabis abstinence, to consider using the t-break guide (intervention) in their attempt, and to complete a follow-up survey after 30 days. participants were young adults aged 18-29 recruited through posters and tabling events at the university of vermont (uvm), a post on a uvm webpage, emails on listservs of seven other universities, and a post on a subreddit focusing on responsible cannabis use. the posters and online announcements directed participants to the online baseline survey, which contained consent information before allowing participants to complete. after completing the baseline survey, participants received a link to an online version of the t-break guide through email. after 30 days, participants received another email prompting them to complete the follow-up survey. the uvm institutional review board reviewed and approved all study procedures (study00001489).

Eligibility criteria:
inclusion criteria: * current cannabis partakers, willing to attempt at 21 day tolerance break (ie, period of cannabis abstinence) exclusion criteria: * no cannabis use in past month

Keywords: open pilot study pre test / post test
study of osteopathic manipulative medicine on the autonomic nervous system

Conditions: Osteopathic Manual Manipulation of Neurovascular Regulation

Summary: the purpose this study is to determine which manual medicine technique or combination of techniques has the greatest effect on the natural changes in heart rate.

this study intends to examine how three different omm techniques, sub-occipital release, rib-raising, and stellate ganglion release, impact autonomic nervous system tone. subjects will be randomly assigned to one of four cohort groups, receiving either sub-occipital release, rib-raising, stellate ganglion release or all three treatment techniques. a shift towards sympathetic tone will be induced in all subjects using a tilted-to-seated-position test (tilt-seated position test) and cognitive challenge test, consisting of computerized questions that become progressively more difficult, and which subjects are asked to answer as quickly and accurately as possible. these stress tests will be induced twice, once without any omm treatment and a second time with the designated omm treatment(s). the sympathetic-dependent response to orthostatic change and cognitive challenges will be determined by fourier analysis of heart rate variability, recorded using an ekg attached to each subject.

Eligibility criteria:
inclusion criteria: * healthy individual capable of giving consent between the ages of 20-50 * normal blood pressure as defined by the seventh report of us national committee on prevention, detection, education and treatment of high blood pressure * normal ekg * normal heart rate exclusion criteria: * chronic cardiovascular disease (including but not limited to: congestive heart failure, previous myocardial infarction, any cardiomyopathy, any arrhythmia, or previous cardiac surgery) * hypertension as defined by the seventh report of us national committee on prevention, detection, education and treatment of high blood pressure or hypertensive medications * smoking * asthma * pregnancy * diabetes * current or recent illness (within the past 7 days) * any manipulative therapies within the previous 7 days (including but not limited to: osteopathic manipulative treatment, massage or acupuncture) * well conditioned athletes (such as long distance runners) * anyone who fails to have an increased heart rate with the passive tilt test (50 degrees head-up)

Keywords: osteopathic manipulative medicine autonomic nervous system heart rate variability sub-occipital release rib-raising stellate ganglion release
case control study: determinants of osteoporosis in gold ii copd patients.

Conditions: Chronic Obstructive Pulmonary Disease; Osteoporosis

Summary: patients with copd have been found to have an increased risk of osteoporosis. the underlying mechanism is not clear yet. this case control study aims to identify risk factors for osteoporosis in gold ii copd patients. copd gold ii patients with osteoporosis (cases) will be matched by gender and age to copd gold ii patients without osteoporosis(controls). possible risk factors for osteoporosis are: * bmi/vvmi (body composition) * emphysema vs chronic bronchitis * physical capacity * use of certain medication (eg corticosteroids, ssri's) * nutritional status * infectious parameters outpatients from the pulmonary ward of the catharina hospital eindhoven with gold ii copd according to the ats and gold-guidelines will be included in the study (after written informed consent). a dexa-scan will be made, if patients are osteoporotic or have a normal bmd they will be included in the study. a hrct will be made, a six minutes walking distance will be performed, blood will be drawn for lab. analysis, an x-ray of the vertebral collum will be made, impedance will be measured and hight and weight will be measuered. also patients will fill in a questionaire. by univariate and multivariate analysis the collected data will be analysed to determine possible risk factors for th development of osteoporosis in copd gold ii patients.


Eligibility criteria:
inclusion criteria: * age \>= 40 years * gold ii copd * written permission exclusion criteria: * age \< 40 years * no copd or copd gold i, iii or iv * no written permission

Keywords: copd osteoporosis bmd dexa-scan
the effect of intravenous lidocaine and intraperitoneal lidocaine irrigation on pain after laparoscopic cholecystectomy

Conditions: Postoperative Pain

Summary: this prospective randomized study aims to comparison the effectiveness of intravenous lidocaine injection and intraperitoneam lidocaine irrigation on the relief of pain in patients undergoing laparoscopic cholecystectomy. a total of 83 patients will be randomized into one of three groups (group c or group i or group p) based on excel number generation. patients in group c will receive normal saline intravenous injection, and patients in group i will receive an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr. patients in group p will receive intraperitoneal lidocaine irrigation with 3.5 mg/kg lidocaine and normal saline 100cc. visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (fpb) of a patient-controlled analgesia system will be recorded at 2, 4, 8, 12, 24, 48 hours postoperatively.


Eligibility criteria:
inclusion criteria: * laparoscopic cholecystectomy exclusion criteria: * mental change * allergy to local anesthetics

Keywords: pain lidocaine intravenous intraperitoneum laparoscopic cholecystectomy
study of airway pressure release ventilation and intracranial pressure in patients with severe traumatic brain injury

Conditions: Injury, Brain, Traumatic; Traumatic Brain Injury

Summary: the investigators will conduct an observational crossover study. the investigators aim to recruit 50 participants with severe traumatic brain injury (tbi) requiring intracranial pressure (icp) monitoring during their stay at the neuro trauma icu at the r adams cowley shock trauma center. overall, participants will be monitored, on average, for approximately 6-8 hours during the study period. the investigators do not anticipate the need for prolonged monitoring during the duration of their hospital stay or post hospital period.

each participant at admission will initially receive a primary mode of mechanical ventilation as determined by the attending trauma intensivists. 12-18 hours after recruitment, continuous monitoring of participants' icp and hemodynamic status will commence to collect participants' baseline data for 30 minutes. participants will then undergo low tidal volume mechanical ventilation (lotv), serving as a control mode of ventilation, for 2 hours prior to switching back to the primary mode of ventilation for 30 minutes. next, patients will be placed on airway pressure release ventilation (aprv) for 2 hours. while receiving aprv, participants intracranial pressure and hemodynamic status will be continuously monitored and recorded for comparison and analysis. after 2 hours of aprv, patients will be switched back to their previous mode of ventilation and more data collected for another 30 minutes.

Eligibility criteria:
inclusion criteria: * intracranial pressure monitoring device present * mechanically ventilated * clinically stable as determined by the critical care attending exclusion criteria: * age \<14 * prisoners * initial mode of ventilation is aprv * provider's judgement * pregnant

Keywords: mechanical ventilation intracranial pressure airway pressure release ventilation
effects of equine assisted activities on veterans with post-traumatic stress disorder

Conditions: Stress Disorders, Post-Traumatic

Summary: the study will examine the effects of eight weeks of equine assisted activities (eaa) on co-regulation, basal physiological values, and symptom severity in veterans with post-traumatic stress disorder (ptsd). heart rate, respiration rate, surface electromyography (emg) and plasma concentrations of cortisol, epinephrine, norepinephrine, and oxytocin will be measured at rest and during dyadic interaction tasks (human to human or human to horse) to assess effects of eaa on these measures. additionally, standard and regularly used questionnaires will be used to monitor ptsd symptom severity during the study and 6-month follow-up period. eaa is expected to lower ptsd symptom severity, and mitigate other physiological changes associated with ptsd.


Eligibility criteria:
inclusion criteria: * male * was deployed and experienced combat in iraq or afghanistan * between 18 and 65 years of age exclusion criteria: * female * amputation * severe traumatic brain injury * schizophrenia, bi-polar disorder, or substance dependence in the last 3 months * pacemaker * allergies to horses * previous enrollment in equine assisted activities or psychotherapy in an equine environment

Keywords: veterans, equine