Kornimate/medical-research-clean huggingface dataset:
effects of inhibitory control training in eating behaviors

Conditions: Overweight and Obesity

Summary: overweight and obese individuals will be randomly assigned to a food-specific or generic inhibitory control training. food intake, weight, and neural indices of inhibitory control will be assessed prior, immediately after the 4-week intervention, and 12-weeks after intervention completion to assess the effectiveness of a mobile inhibitory control training intervention over time for health outcomes.

all participants will report to the lab for a baseline session, where their weight, average food intake for three days (using the automated self-administer 24-hour dietary recall \[asa24\] system), neural indices of inhibitory control (as assessed by the n2 event-related potential component during a food and genetic go/no-go task), appetitive drive toward food (as measured by the power of food scale) and basic demographic information will be assessed. based off their gender and baseline levels of inhibitory control (indicated by the n2), participants will be assigned to a four week food-specific inhibitory control training or a generic inhibitory control training. trainings are administered on a mobile device via an app and participants select four our of five business days to complete the trainings on. immediately after the four weeks, participants will come in for a follow-up session where their weight, food intake, n2, and appetitive drive to food will be assessed again. finally, participants will have a 12-week waiting period where they do not complete the trainings. after the 12 weeks, they will come in for a final lab visit where their weight, food intake, n2, and appetitive drive to food will be assessed one last time.

Eligibility criteria:
inclusion criteria: * overweight or obese (bmi \> 25 kg/m2) exclusion criteria: * diagnosis of a psychological disorder (e.g., major depressive disorder, general anxiety disorder), neurological disorder (e.g., epilepsy, stroke), learning disability, or eating disorder (e.g., anorexia nervosa, bulimia nervosa, binge eating disorder) * metabolic/chronic disease (e.g., cardiovascular disease, type ii diabetes) * pregnant or lactating * current participation in a weight loss diet * food allergies * head injury that resulted in a loss of consciousness * avid exercisers (i.e., participate in at least 20 minutes of vigorous physical activity more than three times a week)

Keywords: inhibitory control training food event-related potentials weight reduction
imgn529 in treating patients with relapsed or refractory non-hodgkin's lymphoma and chronic lymphocytic leukemia

Conditions: Lymphoma, Non-Hodgkin; Chronic Lymphocytic Leukemia

Summary: the purpose of this study is to test the safety and tolerability of imgn529 in patients with relapsed or refractory non-hodgkin's lymphoma (nhl) and chronic lymphocytic leukemia (cll).


Eligibility criteria:
inclusion criteria: * relapsed or refractory nhl including tumor types: follicular lymphoma (fl), marginal zone lymphoma (mzl)/mucosa-associated lymphoid tissue (malt), diffuse large b-cell lymphoma (dlbcl), mantle cell lymphoma (mcl), chronic lymphocytic leukemia (cll). * adequate organ function * ecog ≤ 2 * recovered or stabilized from prior treatments. exclusion criteria: * allogeneic stem cell transplantation * pregnant or lactating females * known central nervous system, meningeal or epidural disease including brain metastases
study of leukocyte immunophenotype and the lipid transport system as predictive biomarkers of severe bacterial infections

Conditions: Sepsis; Infective Endocarditis; Pneumonia, Bacterial

Summary: current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods for predicting the course and outcome of severe bacterial infections.

* to study the state of the immune system in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis): spontaneous and stimulated production of reactive oxygen species by blood neutrophils; spontaneous necroptosis, apoptosis and pyroptosis of neutrophils; the content of blood leukocyte subpopulations. * assess the clinical, biochemical status, state of the lipid transport system of patients with severe bacterial infections (in the model of pneumonia, infective endocarditis, sepsis), including determination of the cholesterol content in the cell membrane of t-cells and monocytes. * to develop a method for predicting an unfavorable course and an algorithm for the treatment (immunocorrection) of severe bacterial infections (on the model of pneumonia, infectious endocarditis, sepsis) based on the determination of the clinical and immunological status, indicators of the lipid transport system and dysmetabolic disorders, and propose a correction method for the treatment of these diseases, supplementing existing clinical protocols (preparations of immunoglobulins, lipids for parenteral nutrition, possibly pcsk9 inhibitors).

Eligibility criteria:
inclusion criteria: * community-acquired pneumonia, severe course (according to idsa / ats criteria) and / or sepsis with different localization of the primary focus (sofa\> 2); * the patient's ability to comply with the instructions of the research doctor and follow the procedures required by the test protocol; * informed consent. exclusion criteria: * acute and chronic heart failure; * renal failure; * acute and chronic liver failure; * taking medications of the statin group during the last month before the study; * diabetes in the stage of clinical and metabolic decompensation; * acute and chronic leukemia, severe anemia; * pregnancy or lactation; * hiv infection; * drug addiction; * immunosuppressive therapy; * malignant neoplasms over the past 5 years.
study to evaluate the safety, tolerability, and action of amg 357 in females with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to find out if amg 357 is safe and tolerated by women with rhematoid arthritis.


Eligibility criteria:
inclusion criteria: * subject provided informed consent. * rheumatoid arthritis present for ≥ 3 months. * global functional class i, ii, or iii. * history of or positive for, rheumatoid arthritis * taking methotrexate consecutively for ≥ 12 weeks and on a stable dose at 10-25 mg weekly. * subjects currently taking nsaids or oral corticosteroids. * normal ecg values * immunizations up to date. exclusion criteria: * positive hepatitis b, hepatitis c, positive hiv * sensitivity to any of the products or components to be administered. * malignancy within 3 years * presence of recurrent or chronic infections * evidence of infections within the 30 days prior to randomization * presence of a serious infection * prosthetic joint infection within 3 years or native joint infection within 1 year * history of exposure to tuberculosis without a history of prophylactic treatment * class iv ra. * felty's syndrome * chronic pelvic pain or hemorrhagic ovarian cyst within 3 years * any bleeding disorder that is clinically significant * low white blood cell or neutrophil count * elevated serum creatinine clearance * low hemoglobin and platelet count * received live vaccines within 3 months of first dose * alcohol and/or substance abuse within past 12 months * blood donation within 60 days * positive urine screen for drugs of abuse * any prior use of rituximab in the last 6 months (or other b cell depleting agents) and cd19 levels \< lower limits of normal * use of a weekly or bimonthly biologic within 2 weeks or monthly biologic agents within 4 weeks * corticosteroid injections for acute ra flare within 4 weeks * grapefruit juice or grapefruit containing products within 7 days of first dose. * all herbal medicines, vitamins, and supplements within the 30 days * the use of any experimental/investigational biologic dmard unless off agent for 3 months; or off for 6 months for b cell depleting agents * known gi disease or gi procedures * women of reproductive potential who are unwilling to practice birth control * women who are pregnant/lactating/breastfeeding * subject with igg levels \< lower limit of normal at screening
using prp and cord blood in treatment of covid -19

Conditions: Virus

Summary: covid - 19 is a critical viral infection that affects humans

covid -19 pandemic started was declared in 2020

Eligibility criteria:
inclusion criteria: * patients with positive covid -19 and has symptoms and isolated in the hospital exclusion criteria: * patients with negative test for covid -19
mothers understand and can do it - mid upper arm circumference screening for malnutrition performed by mothers

Conditions: Marasmus; Kwashiorkor; Malnutrition; Degree, Moderate; Malnutrition

Summary: primary objective : to determine whether mothers, given minimal group training, are capable of using a muac (mid-upper arm circumference) bracelet to screen their children for malnutrition and categorise them into one of three groups : 'red' (sam ; severe acute malnutrition), 'yellow' (mam ; moderate acute malnutrition) or 'green' (normal nutritional status) secondary objectives : to establish whether there is a difference in the muac value if measured on the right arm as opposed to the left, in young children to determine whether there is a difference in the muac value if the mid upper arm position is determined visually as opposed to being measured in the 'classical' fashion

severe acute malnutrition (sam) and its complications are major causes of death in under 5s in the developing world. a simple, reproducible, scalable way to recognise acute malnutrition and target early intervention would be a huge advance. can mothers with limited training reliably measure and interpret the results of mid upper arm circumference (muac), a measurement performed with a muac measuring tape costing $0.06? muac contrasts with z-score (whz), which requires both scales and a height gauge, both health worker interventions susceptible to considerable error, sensitive to non-nutritional factors, requiring calculations and growth curves, yet much less accurate in predicting risk of death compared with muac.

Eligibility criteria:
inclusion criteria: * children present in the inpatient malnutrition treatment unit and paediatric service of the mirriah district hospital aged between 6-59 months old * children aged between 6-59 months old in the two villages where the community phase of the study was conducted exclusion criteria: * children receiving treatment in the intensive care unit of mirriah district hospital * children with bilateral oedema * children whose mothers or fathers refused consent to participate in the study

Keywords: acute malnutrition mid upper arm circumference screening
evaluating within-person and between-person effects of a personalized normative feedback intervention on drinking as they are moderated by self-determination

Conditions: Alcohol Drinking

Summary: this study evaluates within-person and between-person effects of a personalized normative feedback intervention and injunctive norms as they are altered by self-determination in heavy drinkers. half of participants will receive personalized normative feedback and the other half will receive control feedback about media use habits.


Eligibility criteria:
inclusion criteria: * student at the university of houston * above 18 years of age * heavy drinker (more than 4 drinks \[women\] or 5 drinks \[men\] on a single occasion in the last 2.5 weeks and drinks, on average, at least once per week.
concurrent aerobic exercise and virtual reality cognitive training

Conditions: Preclinical Alzheimer's Disease

Summary: the study will implement and test a unique virtual reality cognitive training (vrct) combined with concurrent cycling on a recumbent stationary cycle, also known as exergame that seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognition.

the proposed project will implement and test a unique virtual reality cognitive training (vrct) combined with concurrent cycling on a recumbent stationary cycle, also known as exergame that seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognition. cycling through an interesting virtual environment will motivate and engage the older adult to participate in the exercise, and vrct could augment cycling's effects on cognition. the purpose of this project is to demonstrate the feasibility and efficacy of the exergame intervention on cognition through two phases. in phase i, a prototype of the vrct exergame will be developed, followed by a feasibility testing using a single-group mixed methods design. in phase ii a more fully-featured version of the vrct exergame will be developed followed by a an rct which will randomize subjects on a 2:1:1 allocation ratio to 3 parallel groups (exergame:cycling only:attention control). mixed methods will be used to assess outcomes in both phases.

Eligibility criteria:
inclusion criteria: 1. cognitive complaint (defined as answering yes to the question "do you feel that your memory or thinking skills have gotten worse recently?) 2. not engaging in aerobic exercise or cognitive training \>2 days/week, 30 minutes a session in the past 3 months; 3. age 65 years and older exclusion criteria: 1. resting heart rate \> 100 or \< 50 beats/min; 2. dementia (self-report, diagnosis, or scoring \<18 on the modified telephone interview for cognitive status; 3. neurological or major psychiatric disorder since memory problem; 4. significant diseases, symptoms, or other factors that make exercise unsafe 5. current enrollment in another intervention study

Keywords: subjective memory complaint
optimization of nibs for treatment of addiction

Conditions: Opioid-use Disorder; Chronic Pain

Summary: the purpose of this study is to assess the effects of transcranial direct current stimulation (tdcs) applied in conjunction with transcranial ultrasound (tus) for the treatment of addiction in opiate use disorder with chronic pain. the investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.


Eligibility criteria:
inclusion criteria: 1. providing informed consent to participate in the study. 2. 18 to 85 years old. 3. having a diagnosis of oud, in the setting of cp: * oud of more than 6 months duration as defined by diagnostic and statistical manual of mental disorders (dsm-5) \[64\] and a positive urine toxicology screen. * or oud patients who still feel craving or have not received more than 60 mg of methadone/day from the methadone program. 4. lives in the immediate area with no plans to relocate exclusion criteria: 1. the subject is pregnant. 2. recently started on antiepileptic drug therapy. 3. history of illegal stimulant use as demonstrated by urine toxicology. 4. . ingestion of poppy seeds or herbal teas containing papaveris fructus (may cause a positive opiate test for morphine, codeine \[66, 67\]). 5. history of neurological disorders involving stroke, brain tumors, or epilepsy as self- reported (note patients will also be evaluated via electroencephalography (eeg) at baseline 1 week prior to stimulation and any patient showing abnormal eeg activity will be removed)). 6. history of unexplained fainting spells as self-reported. 7. history of head injury resulting in more than a momentary loss of consciousness as self-reported. 8. history of brain surgery as self-reported. 9. contraindications to tdcs applied in conjunction with tus: * metal in the head, or * implanted brain medical devices. 10. suffering from severe depression (with a score of \>30 in the beck depression inventory (bdi), phq-9≥10). 11. active malignancy. 12. history of suicidal behavior or suicide attempts.
seprafilm in the reduction of incidence of bowel obstruction in general surgery

Conditions: Intestinal Obstruction; Digestive System Surgical Procedures

Summary: the purpose of the study is to evaluate the efficacy of seprafilm in reducing the incidence of bowel obstruction and to evaluate the incidence of all serious adverse events (saes) associated with the use of seprafilm occurring within 30 days postoperatively, and the incidence of abdominopelvic abscess within 6 months postoperatively.


Eligibility criteria:
inclusion criteria: * patients who were undergoing colon and/or rectal resections and/or adhesiolysis for treatment of bowel obstruction exclusion criteria: * patients with any medical condition or disease where 5-year survival was not expected * patients undergoing laparoscopy * patients undergoing surgery for treatment of acute abdominal trauma * patients with an abscess (abdominal or pelvic) present during the initial surgery * patients with a history of pulmonary embolus or deep vein thrombosis (dvt) within 1 year of surgery

Keywords: patients undergoing a variety of abdominal surgical procedures
the effect of hepatic vein pressure gradient(hvpg)-guided therapy in cirrhotic patients with esophagogastric varices

Conditions: Gastroesophageal Varices; Cirrhosis

Summary: the purpose of the study is to compare the effect of hvpg-guided individualized therapy and non-hvpg guided traditional therapy in cirrhotic patients for secondary prophylaxis.

the study is a randomized controlled trial of zelen-design. patients randomly enter two treatment groups: 1) the hvpg group and 2) the non-hvpg group. treatment allocation is by block randomization with an equal number for both groups. the results are concealed in opaque envelopes.after randomization, patients will have a second chance to decide if they want to stay in the current group.patients can switch to another group according to their will. if they are in the hvpg group，they will receive hvpg measurement before treatment. if they are in the non-hvpg group, they start treatment without hvpg measurement and receive endoscopic treatment plus carvedilol.the mortality rate and rebleeding rate will be analyzed.

Eligibility criteria:
inclusion criteria: * patients with cirrhosis diagnosed by histology, radiological evidence of cirrhosis, and endoscopic evidence of varices; * patients with a previous history of variceal hemorrhage; * patients admitted to zhongshan hospital and other 6 tertiary centers in shanghai from dec 1, 2015 to sep 31,2018 exclusion criteria: * patients already taken secondary prophylactic treatment including endoscopic, pharmacological, surgical and interventional therapies; * patients with severe systemic diseases such as chronic heart failure or chronic renal failure that will have impact on survival; * patients in pregnancy and lactation; * patients already diagnosed with hepatic cellular carcinoma or other malignant tumors; * patients with contraindication to treatment of endoscopy, surgery and tips: severe coagulation defects, allergic to contrast medium used in tips, hepatic encephalopathy, spontaneous bacterial peritonitis; * patients with conditions that will influence the accuracy of hvpg measurement: cavernous transformation of portal vein, diffused portal vein thrombosis, severe shunt; * patients refuse to give consent to the study.

Keywords: hvpg
near-infrared fluorescence guided robotic pulmonary segmentectomy for early stage lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: lungs are made up of individual lobes. when a lung cancer tumour is detected in one of these lobes, surgeons typically perform a lobectomy. a lobectomy is the surgery most commonly done to treat early-stage lung cancer and requires removal of an entire lobe of the lung, which removes a large amount of lung tissue for patients with small tumours saving as much healthy lung tissue as possible is important. each lobe of the lung has smaller sections called segments. when a lung cancer is in one of these segments, it is possible to remove that segment, without removing the entire lobe. this surgery is called a segmentectomy. compared to a lobectomy, a segmentectomy saves a larger amount of healthy lung tissue. with the advances in screening technology for lung cancer tumours, an increasing amount of very small lung cancer tumours are being found, and the demand for segmentectomy is increasing. a segmentectomy is a hard surgery to perform robotically because it is difficult to view the tissue lines that separate each segment within the lobe. as a result, it is difficult for the surgeon to see exactly which pieces of tissue should be removed. because of these challenges, many patients having robotic surgery will have a lobectomy, even if a full lobectomy is not needed. near-infrared fluorescence (nif) using indocyanine green (icg) fluorescent dye is a recent advancement in the robotic platform of robotic surgery. the surgeon will view the ct scan to determine which segment the tumour is located in. once identified, the surgeon will isolate the segment by cutting off the blood supply to that segment. then icg will be injected into a vein. it is expected that the entire lung, except the isolated segment, which will remain 'dark' as it was isolated from blood supply, will fluoresce, giving off a green hue when viewed with the da vinci firefly camera. the surgeon will identify 'dark' segment, and will remove it. a pathologist will examine the excised tissue to ensure that the tumour was removed in its entirety. once confirmed, the surgeon will end the procedure. if the pathologist determines that the segment removed did not contain the entire tumour, then the surgeon will perform a routine lobectomy. this ensures patient safety and confirms that all participants will have the entire tumour removed from their lung.


Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. tumor size \<3 cm 3. clinical stage 1 non-small cell lung cancer (nsclc) 4. ct-imaging confirming that the tumour is confined to the one broncho-pulmonary segment, rendering the patient a candidate for segmental resection. exclusion criteria: 1. hypersensitivity or allergy to icg, sodium iodide or iodine 2. women who are currently pregnant or are breast feeding; or women of child bearing potential who are not currently taking adequate birth control.

Keywords: lung cancer segmentectomy robotic surgery near-infrared fluorescent ic-green indocyanine green early-stage lung cancer