Kornimate/medical-research-clean huggingface dataset:
dyadic yoga program for patients undergoing thoracic radiotherapy and their family caregivers: the testing of a mobile application delivery

Conditions: Non-Small Cell Lung Cancer

Summary: the goal of the trial is to test the usability, feasibility and acceptability of an unsupervised, appbased yoga program for participants undergoing thoracic rt and their caregivers.

primary objective: the investigators propose to test the usability, feasibility and acceptability of an unsupervised, app-basedyoga program for patients undergoing thoracic rt and their caregivers. the investigators specific aims will be carried out in two parts: part 1: • the investigators will perform the initial usability testing of the working prototypes of both ios and android versions to determine whether users can complete the required tasks successfully and independently and to identify problems with navigation and functioning. the investigators primary objective is to: aim 1: finalize the working prototype of the yoga app using the feedback of 10 participants-caregiver dyads (mixed-methods study). part 2: • the investigators will measure feasibility (e.g., consent and retention rates, adherence), usability of the app, and acceptability of the app-based program in 20 newly recruited participants-caregiver dyads. as an exploratory outcome, the investigators include pre- and post-intervention assessments of objective physical function and self-reported qol. the investigators will also complete semi-structured interviews to collect qualitative data on participants' evaluation of the mobile app and their experience in participating in this research. specific aims are: aim 1: examine the feasibility, usability, and acceptability of an app-based yoga program in 20 patient-caregiver dyads (single-arm trial). aim 2: understand the trial participants' experiences with the mobile app delivery including suggestions for improvement using qualitative methods.

Eligibility criteria:
inclusion criteria: 1. be diagnosed with a non-small cell lung cancer or esophageal cancer and going to receive at least 24 fractions thoracic rt 2. have an ecog performance status of \<2 3. have a family caregiver (e.g., spouse, sibling, adult child) willing to participate both patient and caregiver must meet all the following criteria: 1. be \>18 years old 2. be able to read and speak english 3. be able to provide informed consent 4. have regular (self-defined) access to wifi/high speed internet access exclusion criteria: 1. experiences cognitive deficits that would impede the completion of self-report instruments as deemed by their attending oncologist 2. experiences contraindications to exercise as determined by the clinical team 3. regularly (self-defined) participants in a yoga program in the year prior to diagnosis participants who participated in part 1 are ineligible to participate in part 2 of this protocol.
effect of power breath device on arterial blood gases and diaphragmatic excursion after valve surgery

Conditions: Heart Valve Diseases

Summary: the aim of this study is to evaluate the effect of power breath device on arterial blood gases, diaphragmatic excursion and the 6 min walk test after cardiac valve surgery.

no more studies have been done on the effect of imt by power breath on valvular surgery, so, this study will see the effect of power breath device on arterial blood gases, diaphragmatic excursion and six minute walk test after valve surgery to know enhanced recovery protocols in valvular surgery that accelerate the functional recovery, minimize the length of the hospital stay and decrease cost of treatment.

Eligibility criteria:
inclusion criteria: * female patients with valve surgery (valve replacement or repair with median sternotomy procedure). * age between 25 to 35 years old. * bmi is between 18.5 to 24.5 kg/m2. exclusion criteria: the participants will be excluded if they meet one of the following criteria: * uncontrolled hypertension (systolic blood pressure\>230 mm hg and diastolic blood pressure\>120 mm hg) * patients with coronary artery disease or heart failure. * need for mechanical ventilation for \>24 h or reintubation. * renal and hepatic disorders. * infected or unstable sternum. * patient with pneumothorax after surgery. * metabolic disorders. * pregnant woman. * lactating mother. * smokers * stroke patient
effects of wearable sensor based virtual reality game on balance for stroke

Conditions: Stroke

Summary: pablo is a new virtual reality (vr) game combined with wearable motion sensor system which can targeted intervention in an interactive environment, immediate and sensitive feedback about the user's performance, a motivating effect due to game-based feature. unlike commercial camera systems such as kinect or force platforms, the systems require a continuous sightline or restrict the base of support which may increase risk of falling. few of studies had investigated the rehabilitation effects on balance with pablo for patients with stroke. the purpose of this study is to investigate the effects of virtual reality training through pablo system in patients with chronic stroke.

pablo is a new virtual reality (vr) game combined with wearable motion sensor system which can targeted intervention in an interactive environment, immediate and sensitive feedback about the user's performance, a motivating effect due to game-based feature. unlike commercial camera systems such as kinect or force platforms, the systems require a continuous sightline or restrict the base of support which may increase risk of falling. few of studies had investigated the rehabilitation effects on balance with pablo for patients with stroke. purpose: the purpose of this study is to investigate the effects of virtual reality training through pablo system in patients with chronic stroke. methods: a prospective, randomized, controlled, blinded assessor design was used. patients with stroke were recruited and randomly assigned to a "virtual reality(vr) group" (n = 20) and "functional balance training (fbt) group" (n = 20). after 18 training sessions (60 minutes per session, 2 sessions per week), outcome measures which included the berg balance scale, the timed up and go test (cognition), a gait analysis, the activities-specific balance confidence scale, stroke impact scale (sis), level of pleasure, and frequency of adverse events. the data were analyzed using nonparametric tests, and significance was indicated at α \< 0.05.

Eligibility criteria:
inclusion criteria: * patients were included if they had first stroke with hemiplegia. * could stand for 5 minutes without support. * chronicity of \>6 months. * could understand instructions. * brunnstrom stage of le ≥ⅲ. exclusion criteria: * patients who were aged \ 75 years * patients with visual or auditory impairment who were unable to see or hear the feedback from the device clearly * montreal cognitive assessment \<16 * modified ashworth scale score of \>2 * patients with other medical symptoms that can affect movement.
measuring cardiac output and stroke volume using the physioflow impedance device in pregnant patients

Conditions: Hypotension

Summary: pregnant patients having a cesarean section (cs) under spinal anesthesia experience a variety of hemodynamic changes, such as hypotension due to decreases in cardiac output (co), stroke volume (sv) and/or systemic vascular resistance (svr). measurement of these hemodynamic parameters classically requires insertion of a pulmonary artery catheter (pac) into the heart. however, this invasive method carries significant complications and its use is now reserved for the more critically ill patients. we hypothesize that the physioflow impedance device can be used as a reliable non-invasive monitor to measure hemodynamic parameters during elective cs under spinal anesthesia.

the physioflow impedance device employs a continuous non-invasive method of measuring ten cardiac hemodynamic parameters including flow, resistance, contractility and fluid content. it involves the application of electrocardiogram (ecg) leads on the neck and the thorax to measure resistance of pulsatile blood flow. its benefits are that it is non-invasive, low cost, and easy to operate. thoracic impedance has been validated against the gold standard method of pac. although the physioflow device has been validated in non-pregnant patients, its use in pregnant patients is very limited. moderate to severe hypotension, experienced by these awake patients, can cause significant undesirable symptoms of dizziness, shortness of breath, nausea and vomiting, and also compromise fetal well-being. the etiology of hypotension is multi-factorial,and it is postulated that decreases in cardiac output (co), stroke volume (sv) and/or systemic vascular resistance (svr) may precede decreases in blood pressure. continuous measurement of co and sv by the physioflow impedance device may provide a better understanding of the cause of hypotension so that future management of these patients may include pharmacological interventions used prior to hypotension in order to avoid any undesirable symptoms.

Eligibility criteria:
inclusion criteria: * women undergoing elective cesarean section * women classified as asa 1 \& 2 exclusion criteria: * patients unable to communicate in english * patients with significant cardiac disease * height less than 4 feet or greater than 7 feet * weight less than 67 lbs or greater than 341 lbs

Keywords: cesarean section cardiac output physioflow cardiography, impedance
predictive role of urodynamics on mid-urethral sling failure

Conditions: Urinary Incontinence, Stress

Summary: purpose the aim of this study is to investigate the contribution of preoperative urodynamics to mid-urethral slings (mus) success for developing an algorithm that uses conventional and easily accessible tools methods women with stress urinary incontinence and who desired surgical correction of their incontinence were included in the study. the selection of the procedure was according to an algorithm used in an institution developed by a chief of urogynecology department who had 25 years of urogynecology experience. urodynamic and baseline factors that may be associated with surgery failure were analyzed in mus failure.


Eligibility criteria:
inclusion criteria: * documented pure or predominant sui symptoms for at least 3 months, along with a positive standardized urinary stress test exclusion criteria: * prior incontinence surgery, post-void residual volumes of greater than 100 ml, a history of chronic inguinal or vulvar abscess, hidradenitis suppurativa, genitourinary fistula or urethral diverticulum, reversible cause of incontinence (i.e., drug effect), or any contraindication to surgery

Keywords: urodynamics midurethral sling transobturator tape (tot) tension free vaginal tape (tvt)
risk prediction and its intelligent assessment for cognitive impairment among community-dwelling older adults

Conditions: Cognitive Impairment; Predictive Model; Aging; Cohort

Summary: cognitive impairment is one of the core early signs of dementia, and it is also a key stage for community-based dementia prevention. accurate and convenient prediction of cognitive impairment can help the community to identify and manage the high-risk population of dementia. previous studies had developed several dementia predicting models, but such models may be not suitable for cognitive impairment prediction. based on the national representative follow-up data of chinese longitudinal healthy longevity survey (clhls), this project aims to develop and validate a brief cognitive impairment prediction algorithm among the community-dwelling elderly, using machine learning methods (such as logistic regression, naïve bayes model, extreme gradient boosting tree and so on). finally, based on the constructed model, an easy-to-use online intelligent assessment tool for predicting cognitive impairment risk will be developed. the general practitioners, social workers and the elderly would be invited to use the tool and we will revise the tool according to their suggestions and comments. this project is expected to provide scientific basis and technical support for community-based dementia prevention, and will also be useful for the elderly to easily understand their cognitive health.


Eligibility criteria:
inclusion criteria: 1. aged 65 or over at baseline; 2. with normal cognitive function at baseline (score ≥ 18 on the chinese version of mini-mental state examination, mmse); 3. completed mmse assessment three years later; 4. provided informed consent voluntarily. exclusion criteria: 1. aged \<65; 2. had a history of dementia or mmse score \< 18 at baseline; 3. lost to follow-up or without cognitive function assessment three years later; 4. refused to participate the survey.
saline versus balanced crystalloid in traumatic brain injury

Conditions: Traumatic Brain Injury (TBI) Patients

Summary: the goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of traumatic brain injury (tbi) in moderate or severe tbi patients. this trial will determine whether the use of saline or balanced crystalloids is associated with improved outcomes in tbi patients. participants will 1. be given fluids through the veins, either saline or balanced fluid will be given. 2. from the first day to the day 14 of the hospitalization (or discharge, whichever comes first), vital signs, laboratory values, treatments given, and other medical data will be collected from the medical record. 3. six months later, your final disability, if any, will be assessed during your follow-up with a doctor. it involves answering a short survey that will take about 5 minutes or less.


Eligibility criteria:
inclusion criteria: * trauma patients presenting to the emergency room for initial care * glasgow coma scale ≤ 12 * head ct with skull fracture(s) and/or hemorrhage(s) (\>1cm in any single dimension) with a reported mechanism of trauma exclusion criteria: * severe visceral trauma dictating mortality (visceral injury severity score \> brain injury severity score) * non-survivable brain injury based on the treating physician's judgment * emergent visceral operative intervention before complete trauma assessment * concern for ruptured intracranial vascular malformation * patients who are transferred from another facility
laparoscopic sleeve gastrectomy-induced decline in plasma asprosin and its association with metabolic recovery

Conditions: Obesity, Morbid

Summary: the present study aimed to systematically assess the changes in plasma asprosin levels at 3, 6, and 12 months after lsg, to explore the relationships between asprosin dynamics and key metabolic parameters, including body mass index (bmi), fasting glucose, insulin resistance assessed by the homeostasis model (homa-ir), and lipid profiles, and to compare asprosin concentrations between bariatric patients and healthy normal-weight controls.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years; 2. body mass index (bmi) ≥37.5 kg/m², or bmi ≥32.5 kg/m² with at least one obesity-related comorbidity; 3. availability of complete clinical data and stored plasma samples at preoperative baseline and at 3, 6, and 12 months postoperatively. exclusion criteria: 1. history of prior bariatric or gastrointestinal surgery; 2. active malignancy, chronic inflammatory or infectious disease, or severe hepatic or renal dysfunction; 3. pregnancy during the study period; 4. incomplete clinical or biochemical data.

Keywords: bariatric surgery asprosin
uro-dna collection for expanded genome-wide association study (gwas) of renal cell carcinoma (rcc)

Conditions: Kidney Cancer

Summary: in the last decade, investigators from the department of cancer epidemiology and genetics (national cancer institute, usa) have conducted genome-wide association (gwas) studies of renal cell carcinoma. dr. mark purdue and dr. stephen cahnock (department of epidemiology of cancer and genetics, nci) propose to expand their genome-wide association study (expanded gwas) by genotyping approximately 10,000 additional cases of kidney cancer patients, in collaboration with us institutions, south-american and european. this study describes the participation of the french kidney cancer research network (uroccr) in the expanded gwas research, under the coordination of professor bernhard (bordeaux university hospital).

the aim of the expanded gwas study is to better understand the role of common genetic variants in susceptibility to renal cell carcinoma (rcc). the participation of the french uroccr network consists in completing the bio-collection of the uroccr cohort by preserving constitutional dna and to provide dna samples to the us nci team. this will increase the number of samples for meta-analysis and contribute to better identify clear cell kidney cancer susceptibility loci.

Eligibility criteria:
inclusion criteria: * patients over 18, * confirmed cases of renal cell carcinoma (any rcc histology) of european or african origin, * patients included in the uroccr study, * free, informed, written and signed consent by the participant and the investigator (at the latest on the day of inclusion and before any investigation required by the research) for specific blood collection for the purpose of dna extraction, * programmed or ongoing management for kidney tumor, * constitutional dna available (whole blood) for selected cases, * affiliated person or beneficiary of a social security scheme. exclusion criteria: * patients below 18, * refusal of consent or participation.

Keywords: renal cell carcinoma expanded genome-wide association
guided imagery: reducing stress and improving well-being in pregnant adolescents

Conditions: Stress, Psychological

Summary: the purpose of this study is to examine the effects of a guided imagery intervention on perceived stress in pregnant adolescents.

pregnant adolescents attending a local alternative education program will be subjects of this study. students will participate in four, 15 minute guided imagery sessions over about a 4-6 week period. they will complete a pregnancy specific stress questionnaire before beginning and after completion of the guided imagery protocol. the students will also complete a short 9-question stress measure before and after each of the individual guided imagery sessions. the specific aims are: 1. to evaluate whether a guided imagery intervention reduces perceived stress in pregnant adolescents; and 2. to evaluate whether a guided imagery intervention enhances well-being in pregnant adolescents. the hypotheses are that the intervention will reduce perceived stress and enhance well-being in these subjects. the purpose of this study is to assess whether employing a guided imagery intervention with pregnant teens and education will reduce perceived stress levels and improve well-being.

Eligibility criteria:
inclusion criteria: * all pregnant students ages 13-21 enrolled in the alternative education program for parenting teens were eligible to participate exclusion criteria: * participants were excluded from the study if they delivered their babies prior to completing four sessions of guided imagery intervention.
gardasil reexamination study (v501-059)

Conditions: Human Papillomavirus (HPV) Infection

Summary: this survey is conducted for preparing application materials for re-examination under the pharmaceutical affairs laws and its enforcement regulation, its aim is to reconfirm the clinical usefulness of gardasil through collecting the safety information according to the re-examination regulation for new drugs.


Eligibility criteria:
inclusion criteria: * females and males 9-26 years of age who are vaccinated with the first dose of gardasil for the prevention of any disease caused by human papillomavirus (e.g., cervical cancer, genital warts, etc.) within local labeling exclusion criteria: * participant who has a contraindication to gardasil according to the local label * participants who are vaccinated with gardasil before study start
lifting and tightening of the face and neck utilizing the ulthera® system

Conditions: Facial and Neck Skin Laxity

Summary: this prospective, multi-center, single treatment clinical trial evaluates the clinical outcomes associated with a non-invasive treatment to obtain lift and tightening of facial and neck tissue utilizing the ulthera® system to deliver ultrasound energy in a focused manner below the surface of the skin.

the primary objective of this clinical trial is to demonstrate the effectiveness of the ulthera® system to obtain improvement in overall lifting and tightening of skin.

Eligibility criteria:
inclusion criteria: * male or female, aged 30 to 65 years. * subject in good health. * skin laxity in the lower face and neck. * willingness and ability to comply with protocol requirements and return for follow-up visits. * provides written informed consent and hipaa authorization. exclusion criteria: * pregnant or lactating. * presence of an active systemic or local skin disease that may affect wound healing. * severe solar elastosis. * excessive subcutaneous fat in the face and lower neck. * excessive skin laxity on the face and neck. * significant scarring in areas to be treated. * significant open facial wounds or lesions. * severe or cystic acne on the face. * presence of a metal stent or implant in the facial area to be treated.
application of transcranial direct current stimulation (tdcs) in patients with chronic pain after spinal cord injury

Conditions: Spinal Cord Injury

Summary: the purpose of this study is to determine whether the novel treatment of transcranial direct current stimulation (tdcs) could decrease the pain perception of those with spinal cord injury. we will also determine whether these changes are correlated with the clinical outcome (pain reduction).

the active tdcs stimulation sessions will be compared to sham stimulation. more study details will be provided by spaulding rehabilitation hospital.

Eligibility criteria:
study eligibility criteria (similar to the criteria of the interstitial cystitis network) 1. providing informed consent to participate in the study 2. 18 to 64 years old 3. with traumatic spinal cord injury (complete or incomplete) - for instance, due to fall, car accident or gun shot; (for spinal cord injury only) 4. stable chronic pain for at least the three preceding months(for spinal cord injury only) 5. score higher or equal to 4cm (0 cm= 'no pain' and 10cm='worst possible pain') on the visual analogue scale (vas) for pain perception at the baseline/start of the treatment(for spinal cord injury only) 6. refractoriness to drugs for pain relieve - such as tricyclic antidepressants, antiepileptic drugs and/or narcotics (pain resistant to at least 2 of these drugs supplied in adequate dosages for six months) (for spinal cord injury only) 7. pain is not attributable to other causes, such as peripheral inflammation. 8. no clinically significant or unstable medical or psychiatric disorder 9. no history of substance abuse 10. no neuropsychiatric comorbidity 11. no implanted devices for pain control, such as vagal or deep brain stimulators 12. no contraindications to tdcs: * metal in the head * implanted brain medical devices 13. no pregnancy 14. eligible to mri according to mri screening checklist. 15. no use of ventilators

Keywords: transcranial direct current stimulation spinal cord injury chronic pain brain excitability