Kornimate/medical-research-clean huggingface dataset:
a prospective, randomized, double-blind, parallel, active-controlled clinical study of silicone hydrogel monthly soft contact lens for the safety and effectiveness in visual correction.

Conditions: Myopia

Summary: this was a prospective, randomized, double-blind, parallel, active-controlled clinical study to assess the safety and efficacy of silicone hydrogel contact lens for vision correction.


Eligibility criteria:
inclusion criteria: 1. 20 years old and above. 2. subjects with normal eyes who are not using any ocular medications (excluding ocular lubricants and artificial tears). 3. best spectacle corrected visual acuity greater than or equal to 1.0 for both eyes. 4. with +6.00d \~ -12.00 d spherical power, and ≦1.00 d astigmatism (based on subjective optometry measurements). 5. have worn soft contact lens for at least 1 month prior to the study. 6. willing to comply with the required wearing time and use specified contact lens care product. 7. agree to comply with all study procedures and signed the informed consent form before enrollment. exclusion criteria: 1. anterior chamber infection, inflammation, or abnormality. 2. any active ocular disease that would affect contact lens wear or vision (such as acute and subacute inflammation of the anterior chamber of the eye, eye infection, uveitis, serious palpebral abnormality, corneal hypoesthesia, corneal epithelium abrasion, dry eye and tear duct defection, ocular allergies, highly suspected glaucoma) upon evaluation by the investigators or slit lamp findings. 3. currently using systemic or ocular medications that would contraindicate with contact lens wear (such as, glaucoma eye drops, steroid anti-inflammatory drops, eye ointments, eye gels and other eye medicines). 4. history of herpes simplex keratitis. 5. history of refractive surgery, keratoconus, or irregular cornea. 6. slit lamp findings that are not suitable for inclusion (details of the grading standards for each eye condition are specified in cip section 5.7.5 from page 38 to 43). 7. a pathologically dry eye syndrome (schirmer test \< 5 mm). 8. have participated in any contact lens or contact lens care product clinical trials within the previous 1 month (excluding questionnaire types and specimen collection). 9. currently pregnant or lactation. 10. allergy to any contact lens care product ingredient (such as mercury or topical antimicrobial agent). 11. have experienced discomfort when wearing hydrogel contact lens. 12. subjects who are judged unsuitable for the study by the investigators.
prevention and treatment of stretch marks with stratamark™

Conditions: Stretch Mark

Summary: stretch marks (striae distensae) are a form of scarring that is a natural result of pregnancy, obesity and in some instances occur due to puberty or steroid use. for some people, the stretch marks do not cause a problem, but in many circumstances they can cause physical symptoms such as itchiness, tenderness and pain. for many people stretch marks are also embarrassing and can have detrimental effects on a patient's mood and self-esteem. stretch marks that result from pregnancy most commonly occur on the abdomen, breasts and thighs. topical silicone gel was developed nearly thirty years ago to be used in the treatment of widespread hypertrophic scars (abnormal scars, which may be red or raised/depressed itchy or painful). since this time it has been used successfully on most scar types. . since stretch marks are a form of scarring it is thought that topical silicone gel may be helpful for this scar type also. stratamark™ has been developed using different forms of silicone polymers, in a gel format, that dries to form a very thin and flexible silicone gel sheet making it a convenient therapy for the treatment and prevention of stretch marks. the aim of this clinical research study is to prove or disprove the efficacy, safety and tolerability of stratamark™ in the prevention and treatment of stretch marks. in addition, the knowledge gained from this study may be of benefit to many future patients


Eligibility criteria:
prevention arm - inclusion criteria: * healthy pregnant woman (nulliparous or multiparous) entering into their third trimester (26-28 weeks, visit 1) * not having striae on their abdomen at the time of trial enrollment prevention arm - exclusion criteria: * any significant medical or surgical conditions * current medications liable to interfere with study results or change the skin's response to therapy treatment arm - inclusion critera: • confirmed sd on their abdomen post-delivery treatment arm - exclusion criteria: * any significant medical or surgical conditions * current medications liable to interfere with study results or change the skin's response to therapy

Keywords: pregnancy, striae gravidarum, striae distensae, women's health
driver-guided ablation of persistent atrial fibrillatiom

Conditions: Persistent Atrial Fibrillation

Summary: this is a prospective, single-center, study. a targeted number of 181patients with persistent af will be included according to pre-defined criteria. the ablation procedure consists on the identification of the arrhythmic substrate using a novel integrated mapping technique. we hypothesize that such approach may potentially lead to a mechanisms-targeted ablation strategy of persistent af.

this is a prospective, single-center, study enrolling a total of 181patients with persistent af according to well defined inclusion and exclusion criteria. the ablation procedure consists on the identification of the arrhythmic substrate using a novel integrated 3d mapping technique followed by standard cpva at the end of the procedure. we will ablate substrates showing fast and regular electrical activities, starting from areas with the fastest mean cycle length and/or areas that have consistent rotational or focal propagation pattern and/or areas that comprise the slow conduction zone of possible arrhythmia circuits. after substrate ablation and af termination, arrhythmia inducibility will be assessed and, if not inducible, the procedure will be completed by standard cpva. if af is still inducible, a new 3d map will be performed to identify further targets to be eliminated. electrical cardioversion may be done at the end of the procedure. we hypothesized that such approach may potentially lead to a mechanisms-targeted ablation strategy leading to elimination of arrhythmic sources in individual patients, thus improving their clinical outcome. we will also characterize, identify and target the real pathophysiological substrates. after ablation, af recurrence will be assessed by implantable loop recorder or thans-telephonic ecg recording from the end of the 3 months blanking period to 12 months following the procedure.the duration of this study is expected to be 24 months, from the first patient enrollment to the last patient follow-up.

Eligibility criteria:
inclusion criteria: age (18-85 years), persistent af according to esc/ehra guidelines, first or second ablation procedure, ability to provide informed written consent. - exclusion criteria: secondary af, hyperthyroidism, lvef\<30%, nyha functional class iv, uncorrected valvular heart diseases, contraindication to anticoagulation, left atrial thrombus, recent (\<6 months) myocardial infarction, thoracic surgery for congenital, valvular diseases, history of cerebrovascular events, pregnancy, cancer or other significant comorbidities. -
effects of a thoracic manipulation on hip adductor, extensor, and latissimus dorsi force in those with adductor weakness

Conditions: Muscle Weakness

Summary: the goal of this trial was to determine if a mid-thoracic high velocity low amplitude spinal manipulation improves force output in those with unilateral hip adductor weakness. the main aims were to determine if the intervention: improved hip adductor force and muscle activation immediately and 48 h post manipulation compared to a control group. improved gluteus maximus and latissimus dorsi force and muscle activation immediately and 48 h post manipulation compared to a control group. strength and muscle activation of the hip adductors, hip extensors (gluteus maximus), and shoulder extensors (latissimus dorsi) were measured prior to, immediate after, and 48 hours after receiving a high velocity low amplitude manipulation to the thoracic spine. the manipulation was performed by a licensed chiropractor. a control group received a validated sham manipulation to the thoracic spine. participants were blinded to group assignment.


Eligibility criteria:
inclusion criteria: * unilateral hip adductor weakness, as assessed by manual muscle testing * pain free hip motion * no contraindications to high velocity thoracic spine manipulation including: any known active cancer/ metastatic bone cancer osteoporosis or other metabolic bone disorders signs of spinal cord compression nerve root compression with increasing neurologic deficit signs of vertebrobasilar insufficiency/ cervical artery abnormalities bleeding diatheses angina pectoris exclusion criteria: * current pain in the adductor muscle group * past history of hip surgery * past history of hip fracture * history of spine or rib fractures * psoas muscle group (hip flexor) weakness as determined by manual muscle testing * received a chiropractic manipulation in past week
respiratory mechanics for delivering individualised exogenous surfactant

Conditions: Respiratory Distress Syndrome in Premature Infant

Summary: this study is an interventional, non-pharmacological, multicentric, randomized, controlled, superiority, non-profit study. its primary objective is to evaluate if the administration of surfactant based on fot assessment will allow a 5-day reduction in the duration of respiratory support as compared to standard practice in preterm infants between 27+0 and 32+6 weeks' gestation. the secondary objectives are: 1. to determine if a lung mechanics-based approach for administering surfactant will change treatment timing; and 2. to assess the impact of the novel approach on other neonatal general outcomes. the study will take place within the neonatal intensive care units. non-invasive respiratory support will be delivered by nasal cpap with a starting pressure of 5-8 cmh2o. fio2 will be titrated in order to achieve the target spo2 91-95%. infants matching the clinical criteria for inclusion will be randomized in two arms following the current data protection and confidentiality regulations. central, computer-generated randomization (allocation 1:1) with variable block sizes according to gestational age will be used. infants will be stratified according to gestational age (27+0 -28+6 weeks; 29+0 -30+6 weeks; 31+0 -32+6 weeks) and center. study arms: a) surfactant administration following oxygenation-based criteria (clinical assessment) (control) b) surfactant administration following both lung mechanics assessment or oxygenation-based criteria (clinical assessment) (intervention).


Eligibility criteria:
inclusion criteria: 1. gestational age (ga) ≥ 27+0 and \< 33+0 weeks 2. spontaneously breathing infants, requiring non-invasive respiratory support (nasal cpap or bilevel nasal cpap). criteria for commencement of non-invasive respiratory support: fio2 \>0.30 for target spo2 88-93% or silverman score ≥ 5. 3. inborn 4. written parental consent obtained 5. administration of caffeine bolus 20 mg/kg iv or po as per standard care exclusion criteria: 1. major congenital anomalies 2. need of intubation in delivery suite according to the aap guidelines for neonatal resuscitation or early at the admission in nicu (within one hour from birth). 3. surfactant therapy prior to the study entry 4. severe birth asphyxia, defined by apgar score ≤ 5 at 10 minutes after birth or continued need for resuscitation 10 minutes after birth or ph \< 7.0 or base excess (be) \< -12 mmol/l on umbilical cord or on an arterial or capillary blood sample obtained within 1 hour from birth or moderate to severe encephalopathy 5. respiratory failure secondary to conditions other that rds as identified by lung imaging (air leaks, lung malformations...) 6. any clinical condition which may place the infants at undue risk as deemed by clinicians 7. participation to trials with competitive outcomes or likely to have an impact on the primary outcome of the study 8. outborn patients

Keywords: surfactant respiratory mechanics respiratory oscillometry forced oscillation technique neonatal rds cpap cpap failure premature infant
study on the difference of plasma microrna expression in patients with genetic susceptibility to mental disorders

Conditions: Plasma microRNA in Patients With Genetic Susceptibility to Mental Disorders

Summary: schizophrenia (schizophrenia,sc), biphasic affective disorder (bipolar disorder,bpd), major depression (major depressive disorder,mdd), anxiety disorder (anxiety disorder,an) and other mental disorders have obvious family aggregation, with heritability of 60 -90%. this kind of common mental illness seriously affects the psychosomatic health and quality of life of patients, and places a great mental and economic burden on the society and family. at present, the diagnosis of mental illness is mainly based on clinical symptoms. with the development of molecular biology, genomics has become a new way to study mental illness. microrna (mirna) is a class of eukaryotic endogenously non-coding single-stranded rna, which can regulate gene expression by binding to specific mrna or regulating the protein translation process of specific mrna. mirna widely exists in plasma and serum, and the type and quantity of mirna in plasma and serum change with different physiological and disease conditions. it is reported that the expression profile of mirna in brain tissue of schizophrenia is significantly different from that of normal subjects. in addition, the study found that the specific mirna detected in peripheral blood can directly reflect the condition of the disease, which may use mirna in peripheral blood as a clinical biological marker. in order to detect the expression of various mirna in plasma, high throughput mirna chip detection has become the first choice for primary screening. in this study, the investigators intend to detect the difference of mirna expression in peripheral blood of different types of schizophrenia by high throughput mirna chip, and analyze the correlation between them. it is hoped to provide the basis for the diagnosis and occurrence and development of clinical psychotic patients.


Eligibility criteria:
inclusion criteria: meet the diagnostic criteria of dsm- v (see attached page for details); there is no history of blood transfusion within 1 month. exclusion criteria: physical and nervous system diseases such as brain trauma; history of mental illness such as mental retardation; history of alcohol abuse and drug abuse.
anterior perineal plane for ultra low anterior resection of the rectum

Conditions: Rectal Neoplasms; Colitis, Ischemic; Colitis, Ulcerative

Summary: anal sphincter preserving operations are now commonplace for both cancer and non-cancerous rectal diseases. however, this has not always been the case and this development has been facilitated by the invention of circular stapling instruments, which allow the bowel to be reconnected to the anal sphincters, where it would almost be impossible to do so manually. nevertheless, some patients still require a permanent ostomy, as even with stapling devices ultra low joins of the bowel and sphincter muscles cannot always be performed by a conventional surgery. therefore, a variety of alternative techniques have been proposed to avoid a permanent ostomy, but these have not become widespread due to the technical difficulty in performing them, their failure to completely eradicate rectal disease, and the damage they inflict upon the anal sphincters resulting in poor bowel function after surgery. the ideal ultra low sphincter preserving operation should remove the rectal disease entirely, allow the small or large bowel to be safely joined to the anal sphincters under direct vision, and retain the sphincter mechanism in its entirety. we propose such a technique that we term the appear procedure, which approaches the lower third of the rectum via an incision between the scrotum or vagina, and the anal sphincters. this procedure preserves sphincter integrity, and allows either a stapled or manual join of the bowel to the sphincter mechanism, under direct vision. this trial is being conducted as a pilot study, with the procedure only offered to patients for whom a conventional sphincter saving procedure was technically impossible, or contraindicated.

this study is recruiting patients with distal third rectal pathology, for whom a conventional sphincter saving procedure is contraindicated, or likely to be technically impossible. recruited patients will initially undergo trial dissection by conventional sphincter preserving surgical techniques, which if successful will result in patients entering study arm 1. however, should this not be possible, a trial anterior perineal dissection will be attempted, with patients entered into study arm 2 if perineal dissection is adequate to allow full rectal excision, and preserve sphincter integrity. if during a trial of anterior perineal dissection it is decided that sphincter preservation is not safe, or will not allow eradication of rectal disease, conventional proctectomy will be performed, with patients entering study arm 3.

Eligibility criteria:
inclusion criteria: * all patients regardless of sex * undergoing surgery (with curative intent) to excise the lower third of the rectum who may require a permanent stoma * deemed suitable by multidisciplinary team. exclusion criteria: * patients under the age of 16 * patients in whom sphincter preservation has already been deemed inappropriate for medical or surgical reasons (e.g. by an mdt for oncological cure), or in whom surgery has been deemed generally inappropriate.
autologous hematopoietic stem cell transplantation in ischemic stroke

Conditions: Stroke

Summary: the purpose of this study is to evaluate the safety and efficacy of autologous peripheral hematopoietic stem cell transplantation in ischemic stroke.

stroke is among the main causes of mortality and disability of elderly population which still lack of efficient therapy. stem sell transplantation provides a functional improvement after cerebral ischemia in rat models. our study will recruit 40 ischemic stroke patients which will be divided into 2 groups (20 patients each): treatment group and control group. the former will be implanted with peripheral blood stem cell through anterior cerebral artery or middle cerebral artery (determined by the section of infarction) and receive convention stroke therapy. the latter only receive convention stroke therapy. the investigators expect that transplantation of the peripheral hematopoietic stem cell is safe and efficient to neurological recovery.

Eligibility criteria:
inclusion criteria: * aged 40\~70 * no consciousness disorders * internal carotid artery territory infarction * stroke happened \< 1 year * with stable hemiplegia, but remain dependent in daily life * sss(scandinavian stroke scale) \< 40 exclusion criteria: * pregnant women * can't tolerate the test because of other disease, such as heart failure, liver failure, renal failure, abnormal blood coagulation, aids, combine other tumor or special condition

Keywords: stroke hematopoietic stem cell transplantation
effects of cash transfer for the prevention of hiv in young south african women

Conditions: HIV

Summary: cash transfers to young women for staying in school and its effect on acquiring hiv

the overall purpose of this study is to determine whether providing cash transfers to young women and their household, conditional on school attendance, reduces young women's risk of acquiring human immunodeficiency virus (hiv). the overall goal of the conditional cash transfer (cct) intervention is to reduce structural barriers to education with the goal of increasing school attendance of young women, thereby decreasing their hiv risk.

Eligibility criteria:
inclusion criteria: * female aged 13 to 20 years. * enrolled in grades 8, 9, 10 or 11 at the beginning of the study at schools in the ahdss study site * intending to continue to live in the study site until the end of the follow-up period. * be willing and able to consent/assent to all study procedures including hiv and hsv-2 testing. * able to read sufficiently to use acasi. * have a bank or post office account or have documentation to be able to open a bank or post office account (i.e., birth certificate, south african national identification book, or passport and proof of residence). post office accounts will only be required for participants in the intervention arm. * parent/legal guardian who lives with young woman, willing and able to consent to all study procedures including hiv and hsv-2 testing. * parent/legal guardian has a bank or post office account or has documentation to be able to open a bank or post office account (i.e. south african national identification book, or passport and proof of residence). note that the account may be opened in the name of any adult who resides in the household with the young woman. exclusion criteria: * pregnant by self-report at baseline. * married at baseline. * no parent or legal guardian living in household. * any other reason that the staff feels would jeopardize the health or well-being of the participant or staff or would prevent proper conduct of the study.
evaluation of the effects of less invasive stabilization system (liss) plating techniques in distal femoral fractures

Conditions: Femoral Fractures

Summary: the purpose of this study is to determine whether the rate of fracture healing and fracture union, repaired with the liss device, will be as good as or better than the usual fracture fixation systems.


Eligibility criteria:
inclusion criteria: * the patient has read and agree to the consent * patient is 16 years or older (bones have finished growing) * the injury happened in the last 14 days exclusion criteria: * the patient taking part in another study * the patient has an infection at the operative site * the patient has a health condition that affects bone healing or interferes with their ability to complete the study requirements (questionnaires, examinations), for example paget's disease or osteomalacia * the patient is taking medication that affects bone healing (such as systemic steroids) * the patient has malignant (tumor) disease * the patient is unable to attend follow-up clinic visits