Kornimate/medical-research-clean huggingface dataset:
the relationship between obesity-related molecular typing and traditional chinese medicine constitution

Conditions: Obstructive Sleep Apnea; Obesity

Summary: obesity is an epidemic and a growing problem in the world. there are numerous causes of obesity, the most novel and personalized of which is genetic inheritance. single nucleotide polymorphisms are the most common type of genetic variation among people, regulating the response between the diet and the body. meanwhile, traditional chinese medicine pattern differentiation is also personalized and usually influenced by inheritance, living habits, character and environment and so on. the common constitutions in obesity are qi deficiency, yang deficiency, and phlegm dampness, which are correlated with oxygen, sugar and fat metabolism, also affected by gene expression. therefore, the relationship between constitution, metabolism and genetic molecular typing may be significant in obesity with obstructive sleep apnea patients.

method the adults whose age between 20\~65 years old, bmi between 27kg/m² and 35kg/m², and also have snoring during sleeping are able to be enrolled in the study. then, the general data questionnaire, body constitution questionnaire, physical examination, blood test, and genetic test are provided to subjects. the blood test includes high-density lipoprotein- cholesterol, low-density lipoprotein- cholesterol, total cholesterol, triglyceride, leptin, glucose ac, hemoglobin a1c, insulin; the dna test includes fto、mc4r、bdnf、pparg、adrb3、ucp1. epworth sleepiness scale, laryngoscope and polysomnography are also performed in the patients enrolled. the traditional chinese medicine constitution can be classified and its relationship between different figure types, serum lipid level as well as obesity-related gene can be analyzed. the results will be described after a statistical analysis. aim the aim of this study is to analyze the constitution, finding the association between obesity patients with obstructive sleep apnea and their related molecular typing and traditional chinese medicine constitution.

Eligibility criteria:
inclusion criteria: 1. 27≦bmi≦35 kg/m² and with snoring during sleeping 2. 20y/o\<age\<65y/o with conscious clear 3. no recognition impairment 4. could accept blood test and questionnaire 5. willing to sign informed consent exclusion criteria: 1. age\<20 years old 2. pregnancy or women under breastfeeding 3. patients have been diagnosed with endocrine disorders such as thyroid, adrenal and autoimmune disease 4. patients have been diagnosed with neurological or psychological disorders with recognition impairment 5. patients with severe visual, hearing, or physical impairment that would interfere with questionnaire processing. 6. patients are under other experimental medication 7. patients are under weight-loss drug in recent one month

Keywords: obesity obstructive sleep apnea gene traditional chinese medicine constitution
tissue flossing and lower limb neuromuscular function

Conditions: Physical Performance; Neuromuscular Function; Tissue Flossing; Ischemic Preconditioning

Summary: there is no study investigating different volumes, that is various sets of the configuration of tissue flossing on neuromuscular function. previously, investigators found that 3 sets of tf impaired neuromuscular function assessed with tmg. therefore, the aim is to compare the effects of one and two sets of ts on countermovement jump (cmj) performance and muscle contractile properties.

the primary purpose of the study will be to examine the differences in one and two sets of applying tissue flossing to the thigh muscles on neuromuscular function using tensiomyography (tmg) and cmj, while considering several measurement points after flossing application (i.e., +0.5min, +3min, +6min, +9min, +12min, +15min). a better understanding of the effects of flossing on acute performance enhancement as well as on individual muscle contractile properties could help practitioners to develop specific pre-conditioning activities and consequently improve athletic performance on the field. the investigators hypothesized that: (i) the application of tissue flossing will improve the contraction time of the vastus lateralis muscle as well as the maximal jumping performance, regardless of sets of configuration.

Eligibility criteria:
inclusion criteria: * healthy and physically active male subjects exclusion criteria: * subjects who have latex allergy, hypertension, venous thrombotic disease, cardio-respiratory disease, or neurological disorders, acute and or chronic neuromuscular injuries i.e., with a history of serious lower limb injuries in 12 months period prior to study began will be excluded.

Keywords: physical performance, neuromuscular function, cmj, tmg, pap
study of mdx-1342 in patients with chronic lymphocytic leukemia (cll)

Conditions: Chronic Lymphocytic Leukemia

Summary: the purpose of this study is to see at what dose mdx-1342, a monoclonal antibody, is safe and tolerable for patients with chronic lymphocytic leukemia (cll). information on any responses that patients may have to the drug will also be collected.

chronic lymphocytic leukemia (cll) is a monoclonal hematopoietic disorder characterized by a progressive expansions of lymphocytes of b-cell lineage. these small, mature-appearing lymphocytes accumulate in the blood, bone marrow, lymph nodes, and spleen. cll is a common leukemia in the wester world and accounts for 25% to 30% of adult leukemias. cd19,an integral membrane protein, is expressed by pro-b cells and functions as a co-stimulatory molecule that regulates mature b-cell activation and enhances b-cell proliferation. mdx-1342, a fully human monoclonal antibody, has demonstrated to specifically bind to human cd19 antigen with high affinity. therefore, it is theorized that mdx-1342 will block activation of b cell stimulation, decreasing the number of cancerous b cell clones.

Eligibility criteria:
inclusion criteria: * relapsed/refractory cd19-positive cll * at least 28 days since prior treatment for cll * ecog ps 0-2 * screening laboratory values must be met exclusion criteria: * no prior anti-cd19 antibody tx * no active, uncontrolled infection * no prior allogeneic bone marrow transplant * no autoimmune disease

Keywords: cll chronic lymphocytic leukemia b cell leukemia lymphocyte antibody monoclonal cancer blood
relation among shear stress distribution, stent design, and subsequent vessel healing after drug-eluting stent implantation (shear des)

Conditions: Coronary Heart Disease

Summary: the purpose of this study is to evaluate the differences of wall shear stress distribution among different types of drug-eluting stents and its impact on vessel healing evaluated by intravascular optical coherence tomography evaluation.

background: distribution of wall shear stress (wss) may be different according to stent designs. the impact of wss after stent implantation may impact future vessel healing after current generation drug-eluting stents implantation. although previous studies used ivus (intravascular ultrasound) and angiography to determine wss from computational fluid dynamics (cfd) simulations, new methods using higher resolution oct (optical coherence tomography) are warranted to further evaluate the impact of stent design on wss with current generation drug-eluting stents. methods: for these purpose, we will enroll a total of 30 patients with stable angina who are scheduled for percutaneous coronary intervention. those patients were randomized to thin-strut (81μm) 2-link promus element (pe: n=10), thin-strut (81μm) 3-link xience prime (xp: n=10), or thick-strut (145μm) 2-link nobori stents (no: n=10) and underwent oct and coronary ct angiography (cta) after stenting. post stent wss was calculated using cfd simulations based on patient-specific reconstructed 3d arteries created by the fusion of oct and cta data, normalized using wss in the proximal unstented region. also, follow-up angiography and oct are performed for the assessment of vessel healing as well as wss distribution 8months after stent implantation.

Eligibility criteria:
inclusion criteria: * older than 20 years old. * indication of pci with xience prime, nobori, or promus element. * clinical diagnosis of stable angina, unstable angina or silent ischemia with reference vessel diameters ranging from 2.5-3.5mm. * underwent ct angiography before pci. * to agree to review and record all the clinical course in this research protocol. exclusion criteria: * previous history of pancytopenia, liver function, renal dysfunction, hypersensitive history of the drug. * low ejection fraction (lvef\<=30%), an impaired liver function, and renal dysfunction (egfr\<=40) * severe calcification * stent restenosis

Keywords: shear stress optical coherence tomography drug-eluting stents
chewing clopidogrel in addition to regular oral clopidogrel treatment to improve platelets aggregation in patient with non st elevation mi

Conditions: Platlet Aggregation; Major Bleeding Outcomes

Summary: since the absorption of clopidogrel through the gastrointestinal tract is limited, we want to examine whether adding clopidogrel by chewing will overcome the limited gastrointestinal absorption, and hence will improve the prevention of platelet aggregation.


Eligibility criteria:
inclusion criteria: * male and female older than 18 years old with non-st myocardial infarction exclusion criteria: * current treatment with anticoagulation medication, any type of cerebro vascular event in the past, active bleeding, active peptic ulcer disease, pregnant women, any inability to sign an informed consent of participate in the study
breath stacking technique associated with expiratory muscle training in amyotrophic lateral sclerosis patients

Conditions: Amyotrophic Lateral Sclerosis; Neuromuscular Diseases

Summary: it will be conducted a randomized parallel controlled trial with patients diagnosed with amyotrophic lateral sclerosis (als) to compare two techniques to lung recruitment and cough augmentation, to assess their effects on pulmonary function, global functionally, swallowing and ability to speech in these population.

age over 18 years preserved cognition, evidenced by a score greater than or equal to 24 points in the mini-mental status exam; no barium allergies; without tracheostomy or invasive mechanical ventilation; no diaphragmatic pacemaker and without associated respiratory disease.participants are excluded if they have pregnancy; previous kidney disease or other concomitant diseases; respiratory diseases and hospitalization in intensive care units (icus) during the study.

Eligibility criteria:
inclusion criteria: * diagnosis of neuromuscular disease confirmed by neurologists at the referral center for neuromuscular diseases at brasília prior to screening for recruitment * age over 18 years * preserved cognition, evidenced by a score greater than or equal to 24 points in the mini-mental status exam; * no barium allergies * without tracheostomy or invasive mechanical ventilation * no diaphragmatic pacemaker * without associated respiratory disease exclusion criteria: * pregnancy * previous kidney disease or other concomitant diseases .respiratory diseases and hospitalization in intensive care units (icus) during the study.

Keywords: respiratory function tests deglution disorders
sport injuries during physical activity lessons in secondary school in south of reunion island

Conditions: Athletic Injuries

Summary: tscoleps aims at identifying individual determinants of sport injuries during physical activity lessons in secondary school at reunion island.

sport injuries during physical activities lessons are the first etiology of traumatism in secondary school. epidemiological studies on individual determinants of sport injuries are very scarce and most focused on contextual or mixed determinants. tscoleps is a multicenter case control study with one control paired to one case. a convenience sample of 500 pupils in each group was planned on the base of a range of expected odds ratios.

Eligibility criteria:
inclusion criteria: * in secondary public school classroom in south of reunion island * no age limited exclusion criteria: * none

Keywords: school sport injuries
bedside evaluation of coagulation in children with congenital heart disease

Conditions: Congenital Heart Defect; Blood Coagulation Disorder

Summary: the purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry). the investigators also aim to determine if this device detect post-cardiopulmonary bypass clotting derangements and may help to manage bleeding in this population.

hemostasis, a main concern during and after any surgical procedure, is traditionally monitored by the following laboratory tests: activated partial thrombin time (aptt), prothrombin time (pt), fibrinogen, platelets count. they neither provide a reliable estimate of the risk of bleeding, nor allow determining useful interventions. new investigations of hemostasis are now used and validated during and after surgery: rotational thromboelastometry (rotem®) and impedance aggregometry. this is a quick bedside functional analysis of the patient's clotting. children who undergo surgery under cardiopulmonary bypass (cpb) are particularly at risk of bleeding and this population hasn't been studied with large cohort yet. hypothesis: hemostasis in children with chd, especially when cyanotic, is intrinsically abnormal. the corrective surgery on cpb induces further hemostatic disorders which can be identified by the rotem platelet®. the aim of the study is to evaluate the hemostatic function of the child with congenital heart disease using a point-of-care (platelet-rotem ®) system, before surgery and after alterations induced by cardiopulmonary bypass (cpb). this is a single center, observational, prospective study. expected duration: 2 years. the investigators plan to include 200 patients with chd, 100 patients undergoing surgery with cpb and 100 patients with congenital heart disease requiring cardiac catheterization. recruitment will be conducted by the division of paediatric cardiology. inclusion criteria include an age of 0-16 years and a diagnosis of congenital heart disease requiring surgery with cpb or cardiac catheterization. patients with known dyscrasia or treated with antiaggregant within 10 days/oral anticoagulants within 48h before surgery/catheterization. rotem platelet® test will be performed before surgery/catheterization. patients undergoing surgery will have a second test within 30 minutes after the end of cardiopulmonary bypass. all patients will benefit from the usual cares.

Eligibility criteria:
inclusion criteria: * children between 0 and 16 years, born with a congenital heart disease requiring either cardiac catheterization or surgery with cardiopulmonary bypass * parental and/or patient consent exclusion criteria: * known hemostatic disorder * known platelet function disorder * antiaggregation treatment \<10 days before blood sampling * oral anticoagulation \<2 days before blood sampling * intravenous heparin \<6 hours before blood sampling * patient and parents unable to consent

Keywords: children cyanotic congenital heart defect cardiopulmonary bypass thromboelastometry platelet function tests
efficacy/safety of ecraprost in lipid emulsion for treatment of critical leg ischemia due to peripheral arterial disease

Conditions: Peripheral Vascular Disease

Summary: ecraprost in lipid emulsion is being developed for the treatment of critical leg ischemia (cli), which is the most severe form of peripheral arterial disease (pad). this trial is designed to assess the efficacy and safety of the drug in the treatment of cli.


Eligibility criteria:
inclusion criteria: * critical leg ischemia (cli) defined as distal extremity pain at rest, or peripheral ischemic ulcer(s), with severe hemodynamic impairment as diagnosed by ankle systolic pressure, toe systolic pressure or tcpo2 * the subject has exhausted all standard revascularization treatment options at this time. exclusion criteria: * subjects with a previous major amputation (at or above ankle) * subjects with end stage renal disease (esrd) defined as significant renal dysfunction evidenced by estimated creatinine clearance of \< 20 cc/min, or receiving chronic hemodialysis therapy.

Keywords: ecraprost in lipid emulsion cli peripheral vascular amputation critical limb ischemia due to peripheral arterial disease
effect of ezetimibe coadministration with simvastatin in a middle eastern population: a prospective, multicentre, randomized, double-blind, placebo-controlled trial (0653-151)

Conditions: Hypercholesterolemia

Summary: the primary outcome was percentage reduction of ldl-c after 6 weeks of randomization.


Eligibility criteria:
inclusion criteria: * patients with known coronary artery disease (cad) and primary hypercholesterolemia, who are being treated with simvastatin 20mg. simvastatin consumption meant that subjects must be currently taking simvastatin 20mg daily, and by history have taken at least 80% of daily evening doses for the preceding 6 weeks prior to baseline visit * age of at least 18 years and 75 years or less * calculated ldl-c concentration of at least 2.6 and 4.1mmol/l or less using the friedewald equation, and triglyceride of less than 3.99 mmol/l exclusion criteria: * congestive heart failure (defined as new york heart association class iii or iv heart failure) * uncontrolled cardiac arrhythmias * acute coronary syndrome, coronary bypass surgery or coronary angioplasty within 3 months of study entry * history of unstable or severe peripheral artery disease within 3 months of study entry * uncontrolled hypertension at study entry * uncontrolled or newly diagnosed diabetes mellitus (within 3 months of study entry) * uncontrolled endocrine or metabolic diseases known to influence serum lipids and lipoproteins; known impairment of renal function * active or chronic hepatic and hepatobiliary disease * disorders that would limit study evaluation or participation
effects of inspiratory muscle training on cardiovascular function in hypertension.

Conditions: Reduction of Blood Pressure in Hypertensive Patients.; Improvement of Cardiovascular Autonomic Control.; Improvement of Functional Capacity.; Improvement of Quality of Life.

Summary: the purpose of this study is to determine inspiratory muscle training effects on blood pressure, functional capacity and quality of life in hypertensive patients.

the interaction between respiratory function and cardiovascular system, as well as the present alterations in these systems, due to diseases such as hypertension, diabetes and chronic heart failure, are the factors that potentially participate of the pathogenic frame in these situations. consequently, it is so related to reduction of functional capacity, endothelial dysfunction of the sympathetic and parasympathetic cardiovascular control and morphologic alterations on the skeletal muscles, including ventilatory muscles. on the other hand, a proinflammatory state also participates of this dysfunction and reduced function capacity situation. cardiovascular risk factors, such as hypertension, increased heart rate variability, diabetes and heart failure explain the occurrence of the majority of cardiovascular events in the entire world and so in brazil. studies with experimental models and in patients with cardiovascular diseases identified important inflammatory activity associated to risk factors and preceding clinical events. inspiratory muscle training (imt) shows consistent results in the improvement of functional capacity in athletes, sedentary subjects, heart failure patients and in animals submitted to an imt model. the study of alterations in cardiorespiratory interaction, functional capacity and cardiovascular control mechanisms (sympathetic, parasympathetic by heart rate variability), altogether, in hypertension, is a single opportunity to identify new pathogenic mechanisms involved in the reduction of functional capacity as well as promote its quantification. therefore, the effects of imt on these alterations are still not well understood. in this way, the response to imt is a complement to epidemiologic and clinical models, as potential source of new possibilities in the research field.

Eligibility criteria:
inclusion criteria: 1. age between 25 and 70 2. hypertension in all stages: 2.1. prehypertension - systolic blood pressure (sbp) of 120 to 139 and/or diastolic blood pressure (dbp) of 80 to 89 mmhg 2.2.stage 1 hypertension - sbp of 140 to 159 mmhg and/or dbp of 90 to 99 mmhg 2.3.stage 2 hypertension - sbp ≥ 160 mmhg and/or dbp ≥ 100 mmhg exclusion criteria: 1. disagreement with consent form 2. thoracic pain (angina) 3. hypertension instability 4. antihypertensive drugs alterations within 30 days before or during the study 5. diabetes 6. chronic pulmonary obstructive disease 7. incapability of executing the functional tests 8. asthma 9. chronic heart failure 10. obesity 11. cardiovascular diseases complications

Keywords: inspiratory muscle training hypertension breathing exercises cardiac rehabilitation
the feasibility and efficacy of an extremely brief mindfulness practice

Conditions: Depression; Anxiety; Mental Disorders

Summary: this study will assess the efficacy of brief mindfulness practices on improving mental health in adults who are currently in treatment for mental health concerns. from online instructional videos, each participant will learn a thirty-second or three-minute mindfulness practice that is to be performed at least three times daily over two weeks.

mindfulness meditation and mindfulness-based therapies have been shown to improve many aspects of psychological functioning in individuals with mental health problems. the purpose of this study is to assess the feasibility, acceptability, and efficacy in improving mental health of brief mindfulness practices in adults currently in treatment for mental health concerns. the entire study will be administered online. from online instructional videos, each participant will learn a thirty-second or three-minute mindfulness practice that is to be performed at least three times daily over two weeks. a delayed-treatment control group will begin the intervention after a two-week waiting period.

Eligibility criteria:
inclusion criteria: * regular internet access * able to listen to audio files * currently receiving outpatient care * no change in type of psychotherapy during the past month * if taking medications, a stable, unchanging prescription for the previous month * willingness to sign release of mental health care information * capacity to provide informed consent exclusion criteria: * does not speak and read english