Kornimate/medical-research-clean huggingface dataset:
effects provided by a physiotherapy treatment preventing lower extremity injuries in female football players

Conditions: Anterior Cruciate Ligament Injuries; Injuries, Knee; Prevention & Control

Summary: background and justification: women's football has a percentage of knee injury of 31.8%, and the anterior cruciate ligament lesion is between 2 and 4 times higher than the male. injury prevention programs seek to improve the control of the neuromuscular recruitment, dynamic valgus and lumbopelvic stabilization. recently cibulka and bennett have proposed a new prevention theory based on the strengthening of the external abductor and hip rotator muscles. the objective of this study is to design and carry out a physiotherapy program based on the prevention of modifiable risks factors. design: controlled clinical trial methodology: 2 groups were formed, the first or experimental integrated by the female players from football team called cd oliver (cdo), and control, integrated by the female players of the first team sd huesca (sdh). the investigators will carried out an initial and final evaluation in which they will be collected data on variables of injury incidence, muscle length and torque. a physiotherapy program will be implemented that will consider three areas of weekly action during training, preventive force sessions, compensatory force sessions and physiotherapy sessions.


Eligibility criteria:
inclusion criteria: * have a valid federal license signed by the competent medical authority. * be part of a team registered in the federated league. * train 4 and a half hours a week or more. * compete and train in regulatory fields, with artificial grass. * have a staff composed of a qualified technician, registered and in possession of the corresponding validated license. * sign the informed consent. exclusion criteria: - suffering a lower limb injury at the start of the study.

Keywords: anterior cruciate ligament injuries injuries, knee, female football prevention & control
non-invasive testing for early oeesophageal cancer and dysplasia

Conditions: Oesophageal Cancer; Barrett Esophagus; Barretts Esophagus With Dysplasia

Summary: this study aims to determine whether a breath test could be used for early detection of oesophageal cancer and barrett's high grade dysplasia. patients who are attending for a planned gastroscopy or who are scheduled to undergo elective resection of histologically confirmed early stage oesophageal adenocarcinoma or dysplasia will be approached to provide a breath sample. multi platform mass spectrometry analysis will be performed to establish volatile biomarkers that can discriminate between early stage (t1) oesophageal cancer/ hight grade dysplasia from non cancer healthy controls/non dysplastic barrett's cancer.

the incidence of oesophageal adenocarcinoma has been rising over the last decade. despite improvements in oncological and surgical therapies the associated survival remains poor, mainly due to delays in diagnosis and advanced stage at presentation. identifying patients at earlier stages as well as those at risk of cancer may lead to survival benefit. barrett's oesophagus is an established risk factor for the development of oesophageal adenocarcinoma. it has an established histopathologic progression from low-grade, through high-grade dysplasia (hgd) to oesophageal adenocarcinoma (oac). barrett's oesophagus patients currently undergo regular endoscopic surveillance to allow earlier detection of oesophageal cancer. the primary objective is to evaluate the diagnostic accuracy and clinical utility of the volatile organic compounds (voc) in exhaled breath to detect early stage oesophageal adenocarcinoma and high-grade dysplastic barrett's oesophagus. all patients will be fasted for a minimum of 6 hours prior to the breath sample as part of their routine clinical care. breath collection will be conducted using a previously validated method. samples of breath (500ml) collected using "breath collecting device utilising bags". breath samples collected within thermal desorption tubes (markes international, llantrisant, uk) will be transferred to a central laboratory for analysis by gas chromatography mass spectrometry (gc-ms) and proton transfer reaction time of flight mass spectrometry (ptr-tof-ms). raw data files will be extracted and analysed in accordance with established protocols.

Eligibility criteria:
inclusion criteria: * ≥18 years and ≤90 years of age * undergoing gastroscopy or elective resection of histologically confirmed oesophageal adenocarcinoma/ high grade dysplasia * fasted \>6 hours * able to provide informed written consent exclusion criteria: * any patient \ 90 years of age. * lacks capacity or is unable to provide informed written consent.

Keywords: oesophageal cancer barretts esophagus with dysplasia
rehabilitation protocol for disorders on hand sensitivity in multiple sclerosis patients.

Conditions: Multiple Sclerosis

Summary: sensory disorders in patients with multiple sclerosis are among the most common symptoms encountered. a functional impairment based on sensory disorders of the hand. the hand is a sensory organ that transmits the cerebral cortex protopathic sensitive information, proprioceptive or epicritiques. the view-hand association plays an important role in the understanding of the environment. its exploratory use remains an essential and voluntary basis. the process of recognition of the object passes through manipulation, but operates instantaneously. the brain is able to do a quick summary of the information it receives to determine the nature of the manipulated object. the exploration takes a posteriori, the brain can then determine the details component object (texture, shape, composition, temperature and weight). neurophysiological mechanisms that would explain the analgesic effects of transcutaneous electrical nerve stimulation (tens) are not fully understood. several theories underlying its use as a neuromodulator of pain. the gate control theory has led to the development of tens devices. recruitment of myelinated, large caliber, by the tens electrodes afferent fibers increases the control exerted on spinal level, thereby inhibiting the action of afferent fibers of small caliber related to nociception. this stimulation strengthens the blocking of "gate" at the corresponding cell bodies of spinothalamic tract and reduces the transmission of nociceptive impulses to the spinal cord dorsal horn. this is segmental presynaptic inhibition depends on the area and stimulated. the objective of this study is to improve the quality of life through improved sensitivity disorders of the hand in patients with ms, thanks to reeducation of the hand.


Eligibility criteria:
inclusion criteria: * patients with relapsing remitting ms defined according to poser criteria \[9\] and mcdonald \[5\]. * age ≥ 18 years, male or female sex * patients with sensory disorders interesting hands, evidenced by clinical examination objective. * patients with an edss between 2 and 4 with functional sensitivity parameter ≥ 2. * patients affiliated to a social security scheme. * patients signed informed consent for the study. exclusion criteria: * patients with other central or peripheral disorders may affect the sensitivity of the hand. * patients with allodynia in the study area * patients with a motor and / or deficit cerebellar ataxia of the upper limbs. * patients treated with psychotropic or antiepileptic drugs. * patients for whom a flare occurred affecting the sensitivity of the hand, within 30 days before enrollment. * patients holders of an active implantable medical device. * pregnant women and vulnerable patient population.

Keywords: transcutaneous electrical nerve stimulation, sensitivity, multiple sclerosis,reeducation through labor tactile discrimination
pilot voice sample collection from people with asthma

Conditions: Asthma Chronic

Summary: human speech is as unique as a fingerprint and analysing speech had advanced so much that speech can now be used instead of pin numbers in banking. the investigators want to find out whether changes in everyday speech can signal the worsening of asthma. the investigators are planning to collect voice samples from people as their asthma gets better and worse in order to analyse the changes in voice quality - if any. the participants donating the voice samples will remain anonymous and the voice files will be transferred securely to our analytic system.

over 18 users of the smart asthma app (by smart respiratory products ltd) will be asked if they wish to participate in the study by recording voice samples. the question will be posed within the app and can be answered with a tap. those interested in participating will be shown a short plain english description of the goals and methodology of the project before enrolled. a maximum of 9 voice sample recording session will be carried out on the phones of participants and take less than 2 minutes each, so participants will spend a total of fewer than 18 minutes during the entire trial. sessions will be offered after participants have recorded their asthma symptoms, lung function and inhaler use in the normal course of using the app. participants may accept or decline each individual offer to record their voice. participants will have a chance to play each voice recording before sharing it anonymously with the investigators. participants can discontinue their participation at any time and can ask investigators to delete all their data. the investigators will be analyse collected voice samples for changes in voice quality. the changes in voice quality will be compared against changes in lung function and asthma symptoms to determine what changes in voice quality, if any, are indicative of a change in asthma control.

Eligibility criteria:
inclusion criteria: * current user of the smart asthma app * over 18 * volunteers to participate * agrees to terms exclusion criteria: * none
single minimal conjunctival incision for strabismus

Conditions: Strabismus, Comitant

Summary: the purpose of this investigation is to study the feasibility and inflammatory response of surgery for rectus muscles using a small single bulbar conjunctival incision posterior and parallel to the muscle insertion. patients requiring surgery of at least one rectus muscle with several diagnoses, operated under general or topical / sub-tenon's anesthesia, who had no previous eye muscle surgery, will be recruited. routinary clinical ophthalmological examination will be carried out. after applying a 5-0 pga traction suture, a 3-4 mm single conjunctival incision posterior and parallel to the rectus muscle insertion will be done. a hang-back recession with 6-0 pga suture will be carried out, and the conjunctiva closed by an 8-0 pga single stitch. the main outcome measure will be duration of swelling and hemorrhage, and secondary outcome measure will be motor outcome at 2 months after surgery.

purpose/background: to study the feasibility and inflammatory response of surgery for rectus muscles using a small single bulbar conjunctival incision posterior and parallel to the muscle insertion. methods: patients requiring surgery of at least one rectus muscle with several diagnoses, operated under general or topical / sub-tenon's anesthesia, who had no previous eye muscle surgery, are included. routinary clinical ophthalmological examination is carried out. after applying a 5-0 pga traction suture, a 3-4 mm single conjunctival incision posterior and parallel to the rectus muscle insertion will be done. a hang-back recession with 6-0 pga suture will be carried out, and the conjunctiva closed by an 8-0 pga single stitch. the main outcome measure is duration of swelling and hemorrhage, and secondary outcome measure is motor outcome at 2 months after surgery. results are compared with retrospectively collected data of patients operated using limbal (n= 20) and fornix incision (n= 21) as a point of reference.

Eligibility criteria:
inclusion criteria: * patients requiring surgery of at least one rectus muscle with several diagnoses, operated under general or topical / sub-tenon's anesthesia exclusion criteria: * patients had no previous eye muscle surgery
safety and tolerability study of nbi-98854 for the treatment of subjects with tourette syndrome

Conditions: Tourette Syndrome

Summary: phase 2, open-label, fixed-dose titration study to evaluate the safety and tolerability of nbi-98854 administered once daily for a total of 24 weeks in children, adolescents, and adults with tourette syndrome (ts).


Eligibility criteria:
inclusion criteria: * have participated in and completed the nbi-98854-1501 (t-force green) or nbi-98854-1505 (t-forward) phase 2 study * have a clinical diagnosis of tourette syndrome (ts) * if using maintenance medication(s) for ts or ts spectrum diagnoses (e.g. obsessive-compulsive disorder \[ocd\], attention-deficit hyperactivity disorder \[adhd\]), be on stable doses * subjects of childbearing potential who do not practice total abstinence must agree to use hormonal or two forms of nonhormonal contraception (dual contraception) consistently during the screening, treatment and follow-up periods of the study * adolescent and adult subjects (12 to 64 years of age) must have a negative urine drug screen for amphetamines, barbiturates, benzodiazepine, phencyclidine, cocaine, opiates, or cannabinoids and a negative alcohol screen. subjects who are on stable doses of prescribed and supervised (not as needed) benzodiazepines, opiates, or psychostimulants (for subjects with comorbid adhd) are allowed to participate in the study * be in good general health exclusion criteria: * have an active, clinically significant unstable medical condition within 1 month prior to screening * have a known history of long qt syndrome or cardiac arrhythmia * have a known history of neuroleptic malignant syndrome * have a cancer diagnosis within 3 years prior to screening (some exceptions allowed) * have a blood loss ≥250 ml or donated blood within 56 days prior to screening (subjects 6 to 17 years of age); have a blood loss ≥550 ml or donated blood within 30 days prior to screening (subjects 18 to 64 years of age) * have a known history of substance dependence, substance (drug) or alcohol abuse * have a significant risk of suicidal or violent behavior * have initiated comprehensive behavioral intervention for tics (cbit) during the screening period or at baseline or plan to initiate cbit during the study * have received an investigational drug within 30 days before screening or plan to use an investigational drug (other than nbi-98854) during the study
development of a predictive model for post-discharge nausea and vomiting (pdnv)

Conditions: Nausea; Postoperative Nausea and Vomiting; Postdischarge Nausea and Vomiting; Postoperative Pain

Summary: the primary purpose of this prospective cohort study is to develop a simplified risk model for post-discharge nausea and vomiting (pdnv) in adult same-day surgery patients in the us that will allow clinicians to identify those patients who would benefit from prophylactic antiemetic strategies.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * scheduled for an elective outpatient surgical procedure * understands the nature and purpose of this survey and has signed an informed consent form * willing and able to complete daily components of the patient diary from the day of surgery until the end of the 48 hour assessment * undergoing general anesthesia requiring a tracheal tube or laryngeal mask airway exclusion criteria: * planned inpatient surgery * inability to communicate in english * regional anesthesia alone without general anesthesia, as ponv in this setting is known to be significantly lower \[18, 19\] * persistent or recurrent nausea and/or vomiting before anesthesia due to other etiologies, unless clearly related only to the anxiety due to impending surgery * minors (\< 18 years of age) * current pregnancy by self-report (potentially confounding for etiology of nausea)

Keywords: nausea postoperative nausea and vomiting postoperative pain
long term physical functional limitations in daily living in sars-cov2 infected patients hospitalized in the acute phase then requiring rehabilitation

Conditions: Infection With Coronavirus SARS-CoV2

Summary: infection with coronavirus sars-cov2 (covid-19 disease) is unique with its speed of propagation, structural medical reorganizations and length of stay in intensive care needed, diversity of the affected population (in particular between young persons or fragile subjects), and impact on physical and mental health generated by confinement of populations. fatigue is a major component of covid-19. global muscular weakness is related to immobility, inflammation, corticosteroids treatment, hypoxemia due to pulmonary and/or cardiac infectious attacks and undernutrition suggests major physical functional repercussions. thus, patients affected by covid-19 with acute hospital management require sometimes complex rehabilitation management. retrospective studies on physical functional capacities in patients infected with sars cov1 showed long term physical activity limitations.

the aim of this study is to study factors associated with physical functional limitations in daily living in patients sars-cov2 infected and hospitalized in the acute phase then requiring rehabilitation.

Eligibility criteria:
inclusion criteria : * patient infected with sars-cov2 * in-patient hospitalization in the acute phase because sars-cov2 infection * patient requiring rehabilitation after sars-cov2 infection acute phase * patient adult, aged more than 18 years old * patient accepting to participate in the study exclusion criteria : * patient with cognitive disorder (folstein mini-mental state examination less than 22 on 30 points)

Keywords: observational study cohort study coronavirus infections respiratory distress syndrome adult rehabilitation physical functional performance long term care exercise tolerance clinical study
insight into the uae experience with monoclonal antibodies (sotrovimab )

Conditions: COVID-19 Respiratory Infection

Summary: sotrovimab is a newly developed monoclonal antibody for the treatment of mild and moderate covid-19 patient, who are at high risk for progression to severe covid-19, including hospitalization or death. this includes, for example, individuals who are 65 years of age and older or individuals who have certain medical conditions. the safety and effectiveness of this investigational therapy continues to be evaluated for treatment of covid-19. sotrovimab is not authorized for patients who are hospitalized due to covid-19 or require oxygen therapy due to covid-19. as the clinical trial results are too preliminary for the drug to enter routine use in uae the drug approved only for emergency use, until further evidence shows sotrovimab is effective, so we thought about this study as a tool to assess the success of emirats health service (ehs) strategy for fighting against covid-19 outside the hospital setting.

may 26, 2021, the u.s. food and drug administration issued an emergency use authorization (eua) for the treatment of mild-to-moderate coronavirus disease 2019 (covid-19), as described in the scope of authorization (section ii) of this letter, pursuant to section 564 of the federal food, drug, and cosmetic act (the act) (21 u.s.c. §360bbb-3). may 28,2021 the uae ministry of health and prevention approved the investigational drug for emergency use, and emirats health service considered strategy for fighting against covid-19 outside the hospital setting, based on this strategy ,special protocol was finalized and approved including initiation of infusion units for the drug in ehs hospital and primary health care centers, all infection prevention and control precautions were taken inconsideration . the overall aim of this study is to determine the effectiveness of sotrovimab infusion in cohort of ambulatory patients with early symptomatic covid-19 at high risk for hospitalization, in uae. we expect to assess the proportion of patients who have progression of covid-19 through 28 days as defined by visit to a hospital emergency room for management or illness, or hospitalization more than 24 h for acute management of illness or death. files of patients treated from june 2021 till october 2021 will be reviewed and data will be collected based on the protocol approved from mohap ethical committee.

Eligibility criteria:
inclusion criteria: * all cases received sotrovimab according the eua protocol. * all patient aged 13 and above exclusion criteria: * sever form of the covid-19 disease * hospitalized patient * age less than 13 years old * bmi less than 25 and no risk factors

Keywords: sotrovimab uae experience emirates health service ehs strategy out patient treatment for covid
the effect of peanut ball application on delivery process

Conditions: Birth, First

Summary: this study was carried out to evaluate the effect of peanut ball application on labor process, birth pain, and birth comfort. the data of the study were collected between july 2021 and july 2022 in a training and research hospital in istanbul. 115 pregnant women who met the inclusion criteria of the study were included in the sampling, and the study was completed with 102 (experimental n: 51; control n: 51) pregnant women. data were collected with an introductory information form, visual and verbal pain scales, birth comfort scale, and birth follow-up form.

a group was determined to be involved in the study after obtaining consent from the pregnant women participating in the research. the purpose of the study was explained to all pregnant women, informing them that the data would be anonymized and privacy principles would be adhered to. experimental group: pregnant women who received the peanut ball application were provided with necessary information about the ball and how to use it through visual aids showing the positions provided by the midwife. a total of 5 positions were shown to the pregnant women. the peanut ball was used when the cervical dilation reached 6 cm. pregnant women in active labor, the transition phase, and the second stage with the peanut ball were directed to change positions every 30-45 minutes. emphasis was placed on selecting positions in which the pregnant women felt comfortable. control group: no intervention was made other than routine practices within the clinic for pregnant women. it was observed that pregnant women generally spent the time before delivery lying down and connected to electronic fetal monitoring. in the birth monitoring form, the gestational week found in the patient's file, interventions and medications applied in the first stage of labor, the situation of episiotomy application in the second stage, the newborn's birth time, and 1st and 5th apgar scores, newborn's length, weight, head circumference, and gender were recorded. in both groups, labor pains during the dilation stage were evaluated three times using the visual anolog scale (vas) when the dilation was at 6 cm, 9 cm, and 10 cm. during this period, the pregnant women were asked to rate the pain they felt on the vas scale from 1 to 10, and the values expressed were recorded by the researcher. the childbirth comfort scale and the form indicating mothers' views

Eligibility criteria:
inclusion criteria: * primiparous pregnant women * 37w-40w gestational week (term) * pregnant women over the age of 18 years exclusion criteria: * pregnant women who gave birth by cesarean section * who had received epidural anesthesia/analgesia