Kornimate/medical-research-clean huggingface dataset:
reducing the abuse liability of prescription opioids

Conditions: Addiction

Summary: opioid (commonly called narcotic) pain medicines are, after marijuana, the most commonly abused substances in the united states. patients who take opioids for legitimate reasons may become addicted; for example, as many as 1 in 4 patients meet the criteria for current opioid dependence. it is very important that a way is found to provide pain relief while minimizing the addiction potential of these widely used pain medications. the study aim to find out if the use of another type of medication given in addition to an opioid will reduce the addiction potential of the opioid. the study is trying to find out if the ability of the opioid to relieve pain is changed when given with the other medication, and to see if the euphoric sensation or "liking" of the opioid pain medication is reduced when taken with the other medication.

this study involves the use of an investigational combination of drugs. "oxycodone with risperidone" and "oxycodone with ziprasidone" are called "investigational" because the u.s. food \& drug administration (fda) has not approved these drug combinations for the purpose of this study. individually, each of these drugs is approved by the fda for other reasons (i.e. oxycodone as a painkiller, while risperidone and ziprasidone are approved as anti-psychotic medications), but the administration of these drugs together has not been studied before or been approved by the fda for this purpose. this is the first study involving humans to examine the safety of this combination of drugs and how they work together. the goal of the study is to find out what effects, good and/or bad, it has on people who take them. because the combination has not been studied in humans before, information about the safety and effectiveness is incomplete and all of the side effects are not yet known.

Eligibility criteria:
inclusion criteria: * requirement of prior exposure to opioids exclusion criteria: * presence of psychiatric comorbidity * presence of chronic pain disorder * presence or history of substance use disorder * current analgesic or neuroleptic medication usage (any medication for pain, including over-the-counter analgesics like ibuprofen/acetaminophen) * pregnancy * positive drug urine test * continuous opioid misuse measure score of \< 9 * presence or history of diabetes * presence or history of cardiac disease or arrhythmia

Keywords: opioid
prevention and treatment of low back pain in young female teamgym gymnasts

Conditions: Low Back Pain

Summary: specific stabilization training targeting the deep trunk muscles has shown good effect in the rehabilitation of low back pain (lbp) in young female teamgym (tg) gymnasts. however, if this training can prevent lbp in this young population remains to be investigated. the aim of the present study was to investigate if a specific lumbar stabilization program can reduce and prevent lbp in young female tg gymnasts.

objectives: to study if a progressive specific lumbar stabilization program can reduce and prevent low back pain (lbp) in young female teamgym (tg) gymnasts aged 10-16 years. design a cluster randomized controlled intervention study participants: all available competitive youth female tg teams including gymnasts aged 10-16 years, in the area of stockholm, were invited to participate in the present study. a team consists of approximately 16 gymnasts. fourteen out of 17 teams and a total of 258 gymnasts accepted to participate. gymnasts and parents were informed about the study and written consent was collected. a cluster randomization process was undertaken as follows: the gymnasts in each team answered questions at inclusion and the teams were matched with respect to age, level of competition, amount of training sessions per week and reports of lbp. lbp in this study was defined as; "pain between the 12th rib and the gluteal fold". thereafter a cluster randomization took place. this means that all gymnasts in one team were either in the control or in the intervention group. there were no differences with respect to demographic and training data and reports of lbp between the two groups at randomization. ninety gymnasts did not report lbp at inclusion or during baseline and were included in a subgroup analysis on the preventive effect of the exercise program. methods every week the gymnasts were visited by a registered physical therapist (rpt). the rpt answered questions from the gymnasts concerning injuries and collected a weekly-based questionnaire. the gymnasts in the intervention group were instructed to perform an eight-week progressive specific lumbar stabilization program, implemented in the warm-up at every training session. the gymnasts answered a weekly based questionnaire regarding training and lbp during the intervention period, and thereafter a questionnaire at 3-, 6- and 12 months follow-up. the gymnasts and the coaches were also instructed to continue with the lumbar stabilization program after the intervention period.

Eligibility criteria:
inclusion criteria: * female teamgym teams, aged 10-16 years, in the stockholm area * competing at national or international level exclusion criteria: * male teamgym gymnasts * female teamgym teams on a regional competitive level

Keywords: stabilization training abdominal hollowing gymnastics
parent-mediated intervention targeting insistence on sameness for autistic children

Conditions: Autism Spectrum Disorder; Autism

Summary: this study will examine the potential effectiveness of a virtually delivered parent-mediated intervention for insistence on sameness behaviors in autism and investigate 1) whether caregivers can learn to deliver the adapted supportive parenting for anxious childhood emotions (space) intervention for is via telehealth and 2) whether children will show greater improvement in is behaviors.


Eligibility criteria:
inclusion criteria: * 6:0 to 10:11 years at the time of consent * diagnosed with asd (based on history, review of available medical records including diagnostic testing completed by psychologist) * iq \> or = 75 (based on history, review of available medical records) * report three or more family accommodations for insistence on sameness based on screening measures * english-speaking parent and youth able to consistently participate in study procedures exclusion criteria: * children with significant hearing, language or motor impairment * unstable behavioral and pharmacological treatments (e.g., anxiety medication) to treat anxiety or is behaviors prior to two months to the start of the study and no anticipated changes in treatments during the course of the trial * caregivers who have participated in formal space training * concurrent psychosocial treatment for anxiety or insistence on sameness * children who have a history of prominent school refusal, self-harm, or suicidal ideation

Keywords: supportive parenting for anxious childhood emotions (space) restricted behavior
future internet social and technological alignment research

Conditions: Bipolar Disorder

Summary: bipolar disorder patients frequently presents recurring episodes and often experience subsyndromal symptoms, cognitive impairment and difficulties in the functioning with a low quality of life, relapses of disease and recurring hospitalization. early diagnosis and appropriate intervention may play a role in preventing the neuroprogressive course of bipolar illness. the new technologies represent an opportunity to develop psychological standardized treatments using internet devices that minimizing the limitations of face to face treatments because of its accessibility that allow adjusting to the availability of each user. however, although exist many online psychological programs through web and mobile devices for bipolar disorder, there is not evidence about their efficacy and effectiveness due to the variability in measures and methodology used.

future internet social and technological alignment research (fi-star) clinical trial is a randomized simple blind evaluation within an european project. fistar is developed to compare this technical solution with treatment as usual. bipolar disorder patients are to be included and randomly assigned to one of two treatment groups: 1) the experimental group (tele-care support) and the control group. participants in both groups will be evaluated at baseline (pre-treatment) and at post-treatment.

Eligibility criteria:
inclusion criteria: * having a diagnosis of bipolar disorder. * being aged between 18-50 years. * being in remission (euthymic state). * being familiarity with new technologies (computer and /or smartphone). * being treatment in the mental health network of the basque country (osakidetza). exclusion criteria: * having listening, reading or writing problems. * having a diagnosis of mental retardation. * unavailability of a smartphone. * having manic or depressive symptomatology at the time of inclusion (hamd\> 16 and young\> 8). * having suicidal ideation.
fluid lavage of open wounds (flow): pilot trial

Conditions: Infection; Wound Healing Problem; Nonunion

Summary: the purpose of this trial is to investigate whether irrigation solution (soap vs. saline solution), or irrigation pressure (high vs. low) will decrease the rate of infection among patients with open fracture wounds.

open fractures are an important source of morbidity and are associated with delayed union, nonunion, and infection. preventing infection through meticulous irrigation and debridement is an important goal in management, and different lavage fluids and irrigation techniques (e.g. high or low pressure lavage) have been described for this purpose. there are, however, a limited number of randomized trials comparing irrigating solutions or irrigating technique. we compared the use of castile soap versus normal saline, as well as high versus low pressure pulsatile lavage on the rates of reoperations and complications in patients with open fracture wounds.

Eligibility criteria:
inclusion criteria: * skeletally mature * sustained an open fracture of the appendicular skeleton (type i to iiib). exclusion criteria: * vascular deficit * \[any\] allergy to detergents or castile soap * previous wound infection or osteomyelitis * previous fracture with retained hardware in the injured extremity * operative management more than 24 hours after injury * use of immunosuppressive medication within six months * immunological deficiency or disease conditions * fractures of the hands (distal to the carpus) or toes

Keywords: open wound solution pressure randomized
impact study: a study of valcyte (valganciclovir) for prevention of cytomegalovirus disease (cmv) in kidney allograft recipients

Conditions: Cytomegalovirus Infections

Summary: this study will determine the relative efficacy and safety of up to 100 days valcyte prophylaxis relative to up to 200 days valcyte prophylaxis when given for the prevention of cmv disease in high-risk (d+/r-) kidney allograft recipients. the anticipated time on study treatment is 3-12 months and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * ≥ 16 years of age * cmv seronegative recipient of primary or secondary renal allograft from a living or cadaveric seropositive donor * adequate hematological and renal function * patients and partners must agree to maintain effective birth control for 90 days following cessation of study medication exclusion criteria: * cmv disease, or receipt of anti-cmv therapy within 30 days prior to screening * multi-organ transplant recipient * hepatitis b, hepatitis c or hiv positive * women who are pregnant or lactating
internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks

Conditions: Retinal Detachment; Surgery

Summary: to describe the technique and outcomes of using either inverted or free internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks.

this retrospective observational case series includes nine patients received surgery for retinal detachment due to paracentral retinal breaks developed either from primary rhegmatogenous orgin, or secondary iatrogenic retinal breaks after prior membrane peeling or during surgery for tractional retinal detachment. either inverted or free internal limiting membrane flaps were inserted in the identified breaks, followed by air fluid exchange and gas tamponade. visual acuity and structural changes were evaluated.

Eligibility criteria:
inclusion criteria: * patients with retinal detachment and posterior paracentral retinal breaks located within the equator from january 2017 to january 2018 exclusion criteria: * patient with macular hole * patient with other ocular diseases including ocular hypertension, optic nerve atrophy, glaucoma or chronic uveitis

Keywords: retinal detachment; internal limiting membrane flap; retinal paracentral breaks
transversus abdominis plane (tap) block versus intrathecal morphine for caesarean section - randomised controlled trial

Conditions: Postoperative Pain

Summary: analgesia after cesarean section is still not satisfactory for many women. even if pain reduction is sufficient with the technique of intrathecal morphine injection, side effects such as nausea and pruritus are common. since several years, an alternative technique has been studied, the "transversus abdominis plane (tap)"-block. here a local anesthetic is injected in the abdominal wall muscles, and this has been shown to give a similar analgesic effect compared to intrathecal morphine, with potentially less side effects. with this study, we want to evaluate if the tap-block yields indeed less side effects when compared with intrathecal morphine. the study will be a prospective study with the patients randomized to either a group with intrathecal morphine or a group with tap-block.


Eligibility criteria:
inclusion criteria: subjects must satisfy all of the following criteria to be enrolled into the study: * american society of anesthesiology (asa) physical status less than 3 able to read and understand the information sheet and to sign and date the consent form * scheduled for elective c-section planned with spinal anaesthesia * age\>18 exclusion criteria: potential subjects who meet any of the following criteria will be excluded from participating in the study: * complicated pregnancy defined as having preeclampsia or placenta accreta, increta and percreta. * drug addiction. * contraindication to spinal anaesthesia (history of clotting disorders, septicemia, local infection at the injection site, spinal malformation, elevated intracranial pressure) * contraindication to tap block (skin infection, abdominal wall muscle defect such as hernia and previous abdominal wall mesh). * bmi\>40 kg/m2 * weight less than 50 kg the day of the c-section. * height less than 150 cm or more than 175 cm. * allergy/contraindication to any medication used in the study. * previous median abdominal incision. necessity to perform the c-section urgently before the scheduled date (with less than 24h preparation time).
stomatognathic system assesment, after different methods of establishing the centric relation

Conditions: Temporomandibular Disorders

Summary: patients with complete dentures were examined after the prosthoddontic treatment with two methods of establishing a centric relation: wax rims and gothic arch tracing method. the effectiveness of establishing a centric relation was evaluated.

in the study subjective experiences of patients, wearing complete dentures, were compared. two different methods of determining a centric relation were performed: the traditional method using wax occlusal rims and the gerber method, based on gothic arch tracings. the success rate of establishing a centric relation in both methods was evaluated (rentgenodiagnostics). the influence of the method used to obtain the centric relation on patients stomatognathic system (condyle centralization, pain) was also evaluated. the comparison between two methods was performed and results were analyzed. a centric relation was analyzed in temporomandibular joints and a corelation between tmd symptoms and centric relation was evaluated.

Eligibility criteria:
inclusion criteria: * tmd according to rdc/tmd group i ,ii * edentulous patients wearing complete dentures * patients agreement for taking part in the study exclusion criteria: * analgesic drug addicted patients * neurological diseases with headache (migraine, cluster headache) * trauma in the head and neck region in the past 2 years

Keywords: tmd, centric relation, complete dentures
reconstruction of monocytic immunocompetence by granulocyte-macrophage-colony stimulating factor (gm-csf) in patients with severe sepsis and septic shock

Conditions: Sepsis

Summary: there is basic science evidence that gm-csf reconstructs cellular immunity in septic patients. in this prospective, randomised double-blind, placebo-controlled trial, we investigate whether this can be achieved in patients with severe sepsis and septic shock.

gm-csf reconstructs cellular immunity in septic patients. in this prospective, randomised double-blind, placebo-controlled trial, we investigate whether this can be achieved in patinets with severe sepsis and septic shock.

Eligibility criteria:
inclusion criteria: * severe sepsis or septic shock, * presence of infection, * 2 sirs criteria, * acute organ dysfunction, * immunoparalysis, * informed consent exclusion criteria: * pregnancy, * known allergies to study medication or components, * moribound patient, * autoimmune disease, * hiv-infection, * acute mi or pulmonary embolism, * cpr during last 72 hours, * patients who participate in a different clinical study
pixelshine vs. iterative reconstruction (ir) processing of ct images

Conditions: Cancer, Lung; Cancer Liver; X-rays; Effects

Summary: this study will compare the quality of ct images acquired with very low-dose radiation and processed with commercially available software vs. pixelshine processed images. it would potentially allow imaging facilities to acquire ct scans using lower doses of radiation without sacrificing clarity of ct images. acquiring high quality ct images with low-dose radiation has the potential to enhance patient safety and has significant implications in imaging practices.

patients receiving ct scans as part of their standard treatment will be asked to consent to an additional 5 minutes of imaging using very low-dose radiation prior to the conventional-dose ct scan. the prospective review will be performed in two cohorts: chest ct scans and abdominal ct scans. anonymized images will be processed by conventional ct software and compared to the same images processed with machine-learning-based pixelshine. a board-certified radiologist will assess the noise and visual quality of the imaging data. study patients will receive approximately 10% more dose than a standard ct scan by participating in the study. there are no known short-term safety issues associated with this study. the study-related very low dose radiation is at a level far below that used for conventional x-ray imaging. the study has been approved by the radiation safety committee as part of the review process.

Eligibility criteria:
inclusion criteria: * patients must be 18 years of age or older * patients must be able and willing to consent to participate in this project * patients will be scheduled for a standard of care ct scan exclusion criteria: * this study does not investigate either a specific disease or a specific patient population-it only examines and compares images obtained at low radiation exposure post-processed with algomedica's pixelshine software with conventionally processed images * all other patients will be excluded
chronic pain in children and adolescents.

Conditions: Pain, Chronic

Summary: medically unexplained chronic pain - without identifiable somatic origin - is yet an insufficiently known and explored field in children and adolescents by international clinical works. this research aims to characterize somatic, psychological, psychopathological and environmental (particularly attachment styles and family functioning) processes trough an observational study with three pain management centers. the study concerns children and adolescents from 7 to 17 years old, suffering of medically unexplained chronic pain and their parents who are referred to a pain center. it is composed of a somatic, psychological and family functioning assessment on the one hand and psychopathological and attachment evaluation on the other hand.

participation in the study involves an additional visit to 1 day pain center to answer questionnaires about anxiety, family environment, depression and psychological testing

Eligibility criteria:
inclusion criteria: * children and adolescent with chronic pain no proven medical cause, type of painful somatic complaints within the scope of one of the following diagnoses to icd-10 (international classification of diseases) and dsm-iv and dsm-v (diagnostic and statistical manual of mental disorders) to somatoform disorders, distinguishing between : * pain disorder * somatoform disorder * undifferentiated somatoform disorder * addressed to the pain centers or in pediatric chronic pain services hosting children. * being fluently french-speaking and french-reading exclusion criteria: presence of current or past organic pathology including migraines and epilepsy, which may interfere with somatic expression of studied disorder

Keywords: pain, chronic children
benefit of hemostatic sealant in preservation of ovarian reserve

Conditions: Benign Ovarian Cyst; Cystectomy

Summary: introduction : the most common technique used for ovarian cystectomy is the stripping technique. after stripping the cyst wall, the subsequent bleeding of the ovarian stromal wound is usually controlled by bipolar coagulation or/and by suturing. however, hemostasis achieved with bipolar coagulation could result in damage to the ovarian reserve. to avoid damage to healthy ovarian tissue, hemostasis using various topical hemostatic agents has been introduced to control post- cystectomy ovarian wound bleeding. among these, floseal (baxter healthcare corporation, deer- field, il, usa) is a hemostatic sealant composed of a gelatin-based matrix and thrombin solution. aim: the aim of the study is to evaluate the impact of topical hemostatic sealants and bipolar coagulation during laparoscopic ovarian benign cyst resection on ovarian reserve by comparing the rates of decrease in anti- müllerian hormone (amh). methods: a randomized prospective data collection was made on women aged 18-45 years who planned to have laparoscopic ovarian cystectomy at one of two institutions (n = 80), montpellier university hospital and nimes university hospital, france. patients were randomly divided into two groups treated with either a topical hemostatic sealant (floseal) or bipolar coagulation for hemostasis. preoperative, 3-month and 6-month postoperative amh levels were checked and the rates of decrease of amh were compared.


Eligibility criteria:
inclusion criteria: * cyst diameter between 3 and 10cm * preoperative amh level \>0,5ng/ml * understanding and acceptance of the protocol exclusion criteria: * post-menopausal status * any suspicious finding of malignant ovarian disease * change of contraception method leading to amh variation * allergy to bovine products found before inclusion * pregnancy * patient who has already participated in the protocol * person deprived of liberty by judicial or administrative decision * person protected by law, under tutorship or curatorship * patient participating in another interventional research on the human person in progress * refusal of participation after a period of reflection * patient not affiliated or beneficiary of a national health insurance system

Keywords: ovarien cyst bipolar ovarian reserve hemostatic agent coelioscopy