Kornimate/medical-research-clean huggingface dataset:
elhafez technique combined with dynamic scapulohumeral mobilization in shoulder adhesive capsulitis

Conditions: Adhesive Capsulitis of the Shoulder

Summary: elhafez technique combined with dynamic scapulohumeral mobilization in adhesive capsulitis

elhafez technique is an emerging rehabilitation approach that integrates axillary ultrasound, axillary laser therapy, and post-isometric facilitation (pif) to target capsular stiffness, inflammation, and neuromuscular dysfunction. these techniques aim to enhance tissue healing, improve joint mobility, and reduce pain. when combined with dynamic scapulohumeral mobilization (dsm), which focuses on restoring scapular control and shoulder joint biomechanics, this comprehensive approach may offer superior outcomes compared to conventional treatments. this study aims to evaluate the biomechanical and functional effects of combining elhafez technique with dsm in patients with shoulder adhesive capsulitis. by assessing pain levels, rom, and functional recovery, this research seeks to determine whether this combined intervention provides faster and more effective relief for patients suffering from this condition.

Eligibility criteria:
inclusion criteria 1. adults aged 30-60 years diagnosed with stage 2 (frozen) or stage 3 (thawing) shoulder adhesive capsulitis based on american shoulder and elbow surgeons (ases) guidelines. 2. pain score ≥4/10 on the visual analog scale (vas) for at least 3 months. 3. restricted external rotation of ≥25% compared to the unaffected shoulder. 4. no prior shoulder injections, surgery, or physiotherapy within the last 3 months. exclusion criteria 1. history of shoulder fractures, rotator cuff tears, or labral injuries. 2. systemic inflammatory conditions (e.g., rheumatoid arthritis, uncontrolled diabetes). 3. neurological disorders affecting the shoulder (e.g., stroke, parkinson's disease). 4. current participation in another physiotherapy intervent

Keywords: elhafez technique adhesive capsulitis dynamic scapulohumeral mobilization
fatigue test with an xco

Conditions: Fatigue

Summary: the reliability of the xco endurance test will be assessed in sedentary adults and in overhead athletes. the experimentation will be divided into two sessions. during the sessions, the impact of the test on rotators strength and throwing performance will be explored.

at first, the reliability of the xco endurance test will be assessed in sedentary adults. then, the reliability of the test will be assessed in overhead athletes. the experimentation will include two sessions. during those sessions, the impact of fatigue (induced by the test) on rotator cuff muscles strength and on functional test performance (single arm medicine ball throw) will be assessed. a time of 7 to 10 days will be provided between the two sessions. to perform the xco endurance test, the participant will be seated on a chair, arm at 90° of abduction (in frontal plane), elbow flexed at 90 degrees and positioned on a wooden support. from a 90 degrees of abduction and a neutral position of rotation, the participants will be asked to realise an external rotation movement of 90 degrees and then to go back to the starting position as many times as possible at a speed of 140 bpm. mechanical stops (the wall and an adjustable height table) will be added to make sure that the participants respected the entire range of motion. after adjusting the position, it will be asked to the participants to perform 2 repetitions of 5 movements at 140 bpm (in eccentric and concentric) to get familiar to the rhythm. thirty seconds of rest will be provided between the 2 repetitions to avoid the appearance of fatigue before the test. then, the participants will begin the test. the objective of the test will be to perform the movement as long as possible. the test will be stopped if the volunteers is not able to maintain the rhythm or to do the movement anymore. the modified borg scale will be used to be sure that each subject was really exhausted when the test was stopped. for that purpose, each of them will have to quantify their level of exhaustion on the scale (maximum score = 10) every 30 seconds.

Eligibility criteria:
inclusion criteria: * practice of an overhead sport at least 5 hours a week (overhead athletes group) * not practice an overhead sport (sedentary adults) exclusion criteria: * history of shoulder pain * shoulder pain
studying blood samples from patients with multiple myeloma who were treated with thalidomide or lenalidomide

Conditions: Multiple Myeloma and Plasma Cell Neoplasm

Summary: rationale: studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. it may also help doctors predict how patients will respond to treatment. purpose: this research study is looking at blood samples from patients with multiple myeloma who were treated with thalidomide or lenalidomide.

objectives: primary * to analyze the mechanism of development of thalidomide/lenalidomide-induced venous thromboembolism (vte) in patients with multiple myeloma treated on clinical trial ecog-e4a03 or e-e1a00. * to determine the intensity, dynamics, and specificity of cathepsin g (cg) upregulation in response to thalidomide and lenalidomide treatment. * to determine the specificity and threshold levels of cg for induction of platelet aggregation in response to thalidomide and lenalidomide and the resulting risk for vte development. outline: blood samples obtained before, during, and after treatment with thalidomide or lenalidomide from patients previously enrolled on clinical trial ecog-e4a03 or e-e1a00 are analyzed to determine the total content of cathepsin g (cg) via elisa; to determine mrna levels of cg via rt-pcr; and for platelet aggregation studies. blood samples are collected from healthy volunteers for platelet preparation.

Eligibility criteria:
disease characteristics: * meets 1 of the following criteria: * diagnosed with multiple myeloma and treated with thalidomide or lenalidomide on clinical trial ecog-e4a03 or e-e1a00 * healthy volunteer patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: stage i multiple myeloma stage ii multiple myeloma stage iii multiple myeloma
a trial to learn if linvoseltamab is safe and works in adults with relapsed or refractory systemic light chain amyloidosis (al amyloidosis)

Conditions: Relapsed/Refractory Systemic Light Chain Amyloidosis

Summary: this study is researching an experimental drug called linvoseltamab ("study drug"). this study is focused on patients who have al amyloidosis that has returned or have failed other therapies and need to be treated again. the study consists of 2 phases (phase 1 and phase 2): * in phase 1, linvoseltamab will be given to a small number of participants to study the side effects of the study drug and to determine the recommended doses of the study drug to be given to participants in phase 2. * in phase 2, linvoseltamab will be given to more participants to continue to assess the side effects of the study drug and to evaluate the ability of linvoseltamab to treat al amyloidosis. the study is looking at several other research questions, including: * how many participants treated with linvoseltamab have improvement in the abnormal proteins that cause organ problems and for how long * how many participants treated with linvoseltamab have improvement in the heart or kidney and for how long * what the right dosing regimen is for linvoseltamab * what side effects may happen from taking linvoseltamab * how much linvoseltamab is in the blood at different times * whether the body makes antibodies against linvoseltamab (which could make the drug less effective or could lead to side effects)


Eligibility criteria:
key inclusion criteria: 1. confirmed diagnosis of al amyloidosis, as described in the protocol 2. measurable disease as defined by serum difference between involved and uninvolved free light chains (dflc) concentration, as described in the protocol 3. previously treated after at least 1 prior therapy and requiring further treatment as assessed by the investigator 4. n-terminal pro b-type natriuretic peptide (nt-probnp) ≤8500 ng/l during screening 5. adequate hepatic, hematologic, renal, and cardiac function, as described in the protocol 6. eastern cooperative oncology group (ecog) performance score ≤2 at screening key exclusion criteria: 1. history of other non-al amyloidosis 2. greater than 60% plasmacytosis on a bone marrow biopsy and/or aspirate during screening 3. presence of lytic bone lesion(s) or extramedullary plasmacytoma on imaging during screening 4. myocardial infarction within the past 6 months prior to the first screening visit 5. known active infection requiring hospitalization or treatment with iv anti-infectives within 28 days of first administration of study drug note: other protocol defined inclusion/exclusion criteria apply

Keywords: amyloid light-chain (al) multiple myeloma (mm) pathogenic light chains
developing effective response inhibition training for symptom relief in ocd and trichotillomania

Conditions: Obsessive Compulsive Disorder; Trichotillomania

Summary: obsessive-compulsive disorder (ocd) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses. there is compelling evidence that poor response inhibition is a core cognitive feature of ocd and its related disorders, but no effective intervention exists that directly attempts to address this problematic cognitive deficiency. this study will examine the feasibility and clinical utility of a computerized cognitive training program designed to improve response inhibition among individuals diagnosed with ocd or trichotillomania.this training program offers systematic practice of response inhibition in the form of a 40-level computer game. individuals with these conditions will be randomized to either 8 sessions of (a) computerized response inhibition training (rit) or (b) placebo computer training (plt). we hypothesize that rit will outperform plt in improving response inhibition capabilities and reducing relevant clinical symptoms. in sum, this project is expected to generate important knowledge to guide the development of effective computer-based treatment approaches that may help reduce critical problems of existing treatments such as suboptimal patient retention and treatment under-utilization, thereby improving overall treatment response rates among individuals suffering from ocd and related conditions.


Eligibility criteria:
inclusion criteria: * principal diagnosis of obsessive-compulsive disorder or trichotillomania exclusion criteria: * current substance use problems * current/past psychotic disorder, bipolar disorder, or schizophrenia * attention deficit/hyperactivity disorder or tic disorder * severe depressive symptoms * current psychotherapy * current suicidality * estimated intellectual functioning \< 80 * lack of response inhibition deficits on a stop-signal task

Keywords: ocd trichotillomania response inhibition cognitive training
chole-possum pro validation for prediction of mortality after cholecystectomy for acute calculous cholecystitis: protocol for a prospective multicenter observational study

Conditions: Acute Calculous Cholecystitis Candidate to Early Cholecystectomy

Summary: chole-possum pro is a prospective multicenter observational study on patients with acc candidate to ec. the rationale of the study is to validate the chole-possum pro score for 30-day mortality in this population.


Eligibility criteria:
inclusion criteria: * have a diagnosis of acc as defined by tg18 criteria * be acc candidate to ec during the index admission\* (\* all the patients treated with initial open cholecystectomy, those who undergo elc, those with conversion from laparoscopic to open cholecystectomy or those who undergo bail out procedures (e.g. subtotal cholecystectomy) will be included.) * be ≥ 18 years old * be stratified for the risk of cbds according to the israelian score (29), and, in case of confirmation of cbds receive pre-operative ercp * provide signed and dated informed consent form * willing to comply with all study procedures and be available for the duration of the study. exclusion criteria: * pregnancy or lactation * acute cholecystitis not related to a gallstone etiology * onset of symptoms \>10 days before cholecystectomy\*\* (\*\* patients with acc associated with common bile duct stones who underwent pre-operative ercp could be included if they receive ec within 10 days from onset of symptoms) * concomitant pancreatitis * intraoperative treatment of common bile duct stones * anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.
a comparison of two daily disposable contact lenses

Conditions: Myopia

Summary: this study seeks to evaluate the clinical performance of a recently improved daily disposable contact lens to an established daily disposable contact lens that contains a wetting agent.


Eligibility criteria:
inclusion criteria: 1. they are of legal age (18 years) and capacity to volunteer. 2. they understand their rights as a research subject and are willing to sign a statement of informed consent. 3. they are willing and able to follow the protocol. 4. they would be expected to attain at least 6/9 (20/30) in each eye with the study lenses. 5. they are able to wear contact lenses with a back vertex power of -1.00 to -6.00ds. 6. they have a maximum of 1.00d of refractive astigmatism (i.e. ≤ 1.00 dc). 7. they have successfully worn contact lenses within six months of starting the study. - exclusion criteria: 1. they have an ocular disorder which would normally contra-indicate contact lens wear. 2. they have a systemic disorder which would normally contra-indicate contact lens wear. 3. they are using any topical medication such as eye drops or ointment. 4. they are aphakic. 5. they have had corneal refractive surgery. 6. they have any corneal distortion resulting from previous hard or rigid lens wear or has keratoconus. 7. they are pregnant or lactating. 8. they have grade 2 or greater of any of the following ocular surface signs: corneal oedema, corneal vascularisation, corneal staining, tarsal conjunctival changes or any other abnormality which would normally contraindicate contact lens wear. 9. they have any infectious disease (e.g. hepatitis) or any immunosuppressive disease (e.g. hiv). 10. they have diabetes. 11. they have taken part in any other clinical trial or research, within two weeks prior to starting this study.
the effect of antenatal corticosteroids on early and late perinatal outcomes

Conditions: Preterm Pregnancy; Antenatal Corticosteroid; Perinatal Problems

Summary: in this study, the investigators aims to evaluate whether antenatal corticosteroid administration to women likely to give birth in the late preterm period will reduce early and late neonatal complications and contribute to the literature in this sense.

this study is a single-center prospective case-control study investigating the effect of antenatal corticosteroids administered in the late preterm period on early and late perinatal outcomes. 459 patients who gave birth between 34-37 weeks between june 1,2021 to october 1,2022 in the obstetrics and gynecology clinic of the university of health sciences were included. patient were divided into two groups antenatal corticosteroid administration (n:231) and non-administration (n:228). postpartum early and late perinatal outcomes were compared between these two groups.

Eligibility criteria:
inclusion criteria: * all pregnant women who had normal vaginal delivery, cesarean section or operative delivery between 34-37 weeks * singleton pregnancies resulting in a live birth exclusion criteria: * twin pregnancies * all births before 34 weeks or after 37 weeks * pregnant women with intrauterine ex fetus * fetuses with major congenital and chromosomal abnormalities * pregnant women who administrated antenatal corticosteroids for any reason before 34 weeks

Keywords: antenatal corticosteroids late preterm pregnancy late perinatal outcomes
effectiveness of phone calls intervention on diabetic patients after ambulatory discharge of a tertiary care center

Conditions: Diabetes Mellitus

Summary: the study is a randomized clinical trial, controlled, open label that aimed to compare two groups after discharge of a tertiary care: type 2 diabetes patients followed exclusively by primary care (control group) and patients followed by primary care and supported by phone calls (intervention group).

the investigators designed a randomized controlled trial. patients with stable and controlled type 2 diabetes, and considered to be eligible to discharge from specialized care to primary care will be included. patients with severe neuropathy, not controlled ischemic heart disease and nephropathy stage iv/v will be excluded. enrolled patients will be randomized in two groups: follow-up supported by periodic nurse phone calls plus primary care (intervention group) or followed by primary care team (control group). the intervention group will receive regular telephone calls (every 3 months for 1 year) and will have a toll-free number to resolve questions about the disease management. main outcome is the glycemic control between groups after 1 year of follow-up. secondary outcomes include: rate of hypoglycaemia, blood pressure control,emergency visits, nephropathy progression and death.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes; * patients who met discharges criteria according to endocrinology team; * patients with hba1c \< 8%. exclusion criteria: * patients with stage iv or v nephropathy; * patients with not controlled ischemic heart disease; * patients with severe autonomous or peripheral neuropathy.

Keywords: diabetes phone calls glycemic control
the effect of bone-void filler on anterior knee pain following acl reconstruction

Conditions: ACL

Summary: one of the common complaints after aclr with bptb autograft anterior knee pain. it is thought that this may be due to harvesting the patellar tendon for graft use. specifically, this may be due to the bone defect that is left after graft harvesting. there is currently no consensus on a gold standard for treating the bone defect with surgeons using multiple commercially available bone void fillers as well as autologous bone graft in standard practice. the purpose of the proposed study is to evaluate the effect bone-void filler on anterior knee pain following acl reconstruction bptb autograft.


Eligibility criteria:
inclusion criteria: * patients undergoing aclr with bptb autograft * skeletally mature (as defined by closed growth plates on plain radiograph) * at least 18 years of age * willing and able to provide consent exclusion criteria: * knee with intact acl * skeletally immature (as defined by open physis on plain radiograph) * pregnant * less than 18 years of age * previous acl repair or reconstruction * unable to speak english or perform informed consent * multiligamentous knee injury (two or more ligaments requiring surgical attention) * varus or valgus malalignment greater than 3 degrees
interoceptive intervention for pulmonary hypertension

Conditions: Interoception; Pulmonary Hypertension

Summary: background pulmonary hypertension is a rare and incurable condition characterised by fatigue and breathlessness. the effects of pulmonary hypertension has a significant impact on an individual's emotional wellbeing and there are currently no established psychological interventions to improve this. interoception is defined as the ability to perceive the internal state of the body and emerging research suggests that interventions to improve interoception can improve well-being. aims the project aims to develop an interoceptive based intervention for those with pulmonary hypertension and examine the feasibility and acceptability of this. additional aims are to explore the preliminary results of the intervention. methods a randomised control feasibility trial will be used. thirty-two participants will be included. participants will be patients within the scottish pulmonary vascular unit diagnosed with pulmonary hypertension and randomly assigned to either the intervention or control (waitlist) group. the intervention will be an eight-session online group and participants will complete measures for interoception, anxiety, depression, health related quality of life, as well as a feasibility and acceptability questionnaire. quantitative analysis will include descriptive statistics and t-tests (including non-parametric versions) to analyse the feasibility and gain a preliminary understanding of the intervention. practical applications it is hoped that the findings will identify a sample size for a larger trial whilst also informing future clinical practice. this project will be written up for a suitable journal and will be presented at an appropriate conference.


Eligibility criteria:
inclusion criteria: * participants will be patients under the care of the scottish pulmonary vascular unit (spvu) at the golden jubilee university national hospital (gjunh). * diagnosed with any type of ph. * adults over 18 years. * fluent in english. * able to commit to the duration of the research (expected to be three months from initial recruitment to the end of treatment). exclusion criteria: * individuals with current thoughts of self-harm or suicide. * presenting with comorbid alcohol or substance misuse. * currently engaging in any additional psychological interventions at the time of the study.

Keywords: interoception pulmonary hypertension
dexamethasone versus placebo in optimizing the postoperative period after laparoscopic inguinal hernia repair

Conditions: Inguinal Hernia; Femoral Hernia

Summary: does corticosteroid (dexamethasone) have an effect on the postoperative period after laparoscopic hernia repair, when it comes to pain, postoperative nausea and vomiting and convalescence. this randomized, double-blinded study compares dexamethasone versus placebo. the patients are recommended one day of convalescence. the medicine or placebo is given before operation. the patients fill out questionnaire before operation and three hours after operation and in the following three days. the patients also register when they return to normal activities and work.


Eligibility criteria:
inclusion criteria: * patients planned for elective laparoscopic hernia repair (tapp) * unilateral inguinal or femoral hernia * asa class i-ii * read and speak danish exclusion criteria: * acute hernia operation * operation for other hernias with mesh during the same procedure * endocrine disease (diabetes, adrenal insufficiency etc.) * fever/infection within the first 10 days before operation * poor compliance * no signed consent form * daily intake of opioids or anxiolytic drugs * manic episodes * use medicine against glaucoma * use thiazide or loop diuretics * vaccination within the last 14 days

Keywords: inguinal hernia transabdominal preperitoneal hernia repair tapp dexamethasone pain