Kornimate/medical-research-clean huggingface dataset:
screening for postoperative vital signs abnormalities, and particularly hemodynamic ones, by continuous monitoring using the biobeat patch

Conditions: Surgery--Complications

Summary: brief summary: post-operative morbidity remains a reality as shown by the international surgical outcomes study published in 2016 and 2019 and by several recent publications which focus mainly on hypotension and cardio-vascular complications. other complications, such as respiratory depression, are less often studied. the hypothesis is that this connected patch could be used in surgical departments to detect a postoperative complication. biobeat technologies ltd has developed a sensor which continuously records the photoplethysmographic waveform and allows the calculation of several physiological parameters: heart rate (hr), oxygen saturation (spo2), systolic blood pressure (sbp), diastolic blood pressure (dbp), stroke volume (sv), cardiac output (co), cardiac index (ci), systemic vascular resistance (svr), respiratory rate (rr), and temperature. the objective of this study is the quantification of hemodynamic, respiratory and temperature abnormalities detected by routine monitoring (routine nursing follow-up) and continuous monitoring by the biobeat patch during the first 72 postoperative hours.


Eligibility criteria:
inclusion criteria: * patient 18 years of age or older * patient undergoing major digestive, gynecological, orthopedic or urological surgery (expected duration of surgery greater than 2 hours). * predictable postoperative hospitalization duration ≥ 2 nights * patient with a health insurance plan * not having opposed participation in the research exclusion criteria: * patient with significant deformity, swelling, irritation or with localized infection, ulceration or skin lesions on the torso * patient with a subcutaneous electronic pacemaker implant. * patient with a ct or mri scan already scheduled for the first three days postoperatively * patient suffering from tremors or convulsions * patient with a torso tattoo * patient with significant chest hairiness * patient with a known allergy to metals, plastics and silicone * patient deprived of liberty or under guardianship * pregnancy or breastfeeding

Keywords: surgery vital signs continuous monitoring
dmt310-003 topical in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the objective is to evaluate the tolerability, safety, and efficacy of dmt310 topical powder mixed with diluent in male and female patients with moderate to severe facial acne vulgaris.


Eligibility criteria:
inclusion criteria: * inclusion criteria: * patient is male or non-pregnant female at least 12 years of age. * clinical diagnosis of moderate to severe acne vulgaris as determined by: investigator's global assessment (iga) at randomization patient has at least 20 inflammatory lesions on the face patient has at least 20 noninflammatory lesions on the face * patient is willing to apply the investigational product as directed * patient is willing and able to comply with the protocol exclusion criteria: * patient is pregnant or planning to become pregnant * patient is taking a topical therapy on the face which may affect the patient's acne
evaluation of the role of latent toxoplasmosis in female patients with active acne vulgaris

Conditions: Acne Vulgaris; Toxoplasmosis

Summary: acne vulgaris is one if the most common chronic inflammatory skin disorders.acne is characterized by forming of inflammatory and non inflammatory lesions mainly on the face,neck,arms, upper trunk and back

one of the hidden hormonal imbalance is toxoplasma infection.toxoplasmosis is a zoonotic infection the definite host is feline whereas human and other warm blooded animals are intermediate host . endocrine alterations occuring during toxoplasmosis can be a hidden cause of acne vulgaris

Eligibility criteria:
inclusion criteria: - female patients with active acne vulgaris exclusion criteria: * patients with history of hormonal treatment patients received anti toxoplasma therapy patients with dermatological diseases caused by hormonal disturbances pregnant and lactating patients
test predicting adrenal insufficiency in volunteers under prednisone treatment

Conditions: Adrenal Gland Hypofunction

Summary: suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. identification of patients at risk would be of high clinical importance. the investigators hypothesized that the dexamethasone-suppression-test predicts the subsequent development of corticosteroid induced adrenal insufficiency.

the objective of this study is to evaluate if adrenal axis integrity investigated by the dexamethasone-suppression-test will predict the development of adrenal insufficiency after 14 days treatment with 0.5mg/kg of body weight prednisone in healthy volunteers. the investigators hypothesize that subjects with a more suppressed cortisol level after dexamethasone will be more likely to develop adrenal insufficiency after 14 days intake of prednisone o.5mg/kg/body weight than subjects with less suppression of their cortisol levels after dexamethasone.

Eligibility criteria:
inclusion criteria: * healthy male volunteers over 18 years exclusion criteria: * no informed consent * intake of any kind of medication * bmi over 30kg/m2 * acute or chronic illnesses

Keywords: dexamethasone-suppression-test high dose glucocorticoid treatment population at risk
evaluation of negative inspiratory flow in children with acute asthma

Conditions: Asthma

Summary: there are different inhalers used for the treatment of asthma and they work differently and require different technique for the optimal drug delivery to the lungs. one of the inhalers is the dry powder inhaler (dpi). the minimal amount of negative inspiratory flow (nif) required to use this medication is 30ml/min. studies have shown that children find it difficult to generate this nif and studies have also shown that children generate lesser nif during an asthma exacerbation. the investigators will measure the nif using an incheck dial on children with asthma during an exacerbation and when they are seen in clinic for a hospital follow up visit. this will be done on asthmatic children regardless of the inhaler that they use. the investigator hypothesize that children with asthma age 4-8 years cannot generate the required nif during an asthma exacerbation hence proving that a dpi cannot be prescribed to children at this age. this study will examine this hypothesis.

inhaler devices are the major method for delivery of asthma medication, but their effectiveness can be compromised if the patient uses the inhaler device incorrectly. the magnitude of this problem has been well documented; in several studies less than half of the patients used their inhaler correctly. inhaler devices are used to deliver a variety of inhaled medications, including beta-agonists, anticholinergic, and glucocorticoids. two main types of inhaler devices are available, the pressurized metered dose inhaler (pmdi) and the dry powder inhaler (dpi). a dry powder inhaler (dpi) is a breath-actuated device containing micronized drug particles with a mass median aerodynamic diameter (mmad) of less than 5 µm that are usually aggregated with carrier particles (such as lactose or glucose) of greater diameter. drug is delivered to the airways by the inhalation of air over a punctured drug-containing capsule or blister. in this study investigators will evaluate the use of dpi use in children during an acute asthma exacerbation. the investigators hypothesize the use of dpi in children ages 4-8 during an asthma exacerbation has limited benefit, as children are unable to generate the needed nif. the investigators will study children who were hospitalized for an acute asthma exacerbation. additionally, the investigators will evaluate the participant as an outpatient in the pulmonary clinic / office when the participant is without an asthma exacerbation.

Eligibility criteria:
inclusion criteria: * hospitalized with asthma * age ≥ 4 years and \< 8 years exclusion criteria: * acute lung disease * chronic lung disease * developmental delay
clinical study of anerning particle for the treatment of childhood community-acquired pneumonia

Conditions: Community-acquired Pneumonia

Summary: the purpose of this study is to evaluate the efficacy, safety and whether it can reduction of antibiotic use in the treatment of community-acquired pneumonia in children with anerning granules combined with ceftriaxone sodium.

to evaluate the efficacy, safety and whether it can reduction of antibiotic use in the treatment of community-acquired pneumonia in children with anerning granules combined with ceftriaxone sodium.in this study, a randomized, double blind, parallel control of placebo, multi-center clinical study will be established. according to the relevant regulations of the cfda, 216 cases need to be registered at least.the aim population is children who suffering of community-acquired pneumonia from september 2018 to december 2019. these cases will be devided into treatment group（anerning particle+ intravenous ceftriaxone sodium）,control group（anerning particle simulants+ intravenous ceftriaxone sodium）. each group will be treated for 10 days hospitalization and if there is adverse drug reaction during treatment, follow-up until the laboratory indicators are normal. the efficacy indicators of this study were mainly from three dimensions: frequency of antibiotics at the clinical endpoint, total disease efficiency, clinical recovery time. the symptom scores changes of each group before and after treatment were observed.

Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria for children's cap western medicine and consider bacterial infection; 2. those who meet the diagnostic criteria of tcm syndrome differentiation of wind-heat and closed lung syndrome; 3. children aged 1 to 5 years old; 4. within 48 hours of onset of cap; 5. the informed consent process is in compliance with the regulations, and the legal representative signs the informed consent form. exclusion criteria: 1. chest x-ray films showed obvious lung tumors and tuberculosis; 2. those with acute infectious diseases such as measles, whooping cough, and influenza; 3. other upper respiratory tract infections, wheezing-like bronchitis, bronchial asthma, bronchial foreign bodies and other respiratory diseases; 4. children with severe malnutrition and immunodeficiency; 5. combine severe primary diseases such as severe heart, liver, kidney, digestion and hematopoietic system; 6. those who meet the cap (severe) western diagnostic criteria for children; 7. clinically diagnosed or clinically considered viral pneumonia, mycoplasma pneumoniae pneumonia; 8. allergic constitution (allergic to more than 2 types of substances), or allergic to penicillins, cephalosporin antibiotics and anering granules and their components; 9. researchers believe that it is not appropriate to join the group.

Keywords: anerning particle clinical endpoint antibiotic application frequency efficacy and safety randomized double blind
gait parameters after using the tilt-table exercise and motor imagery.

Conditions: Stroke; Gait; Visualization

Summary: sixty-six stroke patients were randomly assigned to three groups (conventional, with the addition of the erigo®pro table, and enriched with motor imagery). the trunk stability test, walking speed, step symmetry, and lower limb load symmetry on the riablo device, as well as the superficial tension of the transverse abdominis and multifidus muscles, were assessed before and after completing therapy.

sixty-six stroke patients were randomly assigned to three groups (conventional, with the addition of the erigo®pro table, and enriched with motor imagery). the trunk stability test, walking speed, step symmetry, and lower limb load symmetry on the riablo device, as well as the superficial tension of the transverse abdominis and multifidus muscles, were assessed before and after completing therapy. results: in each of the groups studied, the therapies used significantly improved the functional assessment of trunk stability (trunk control test \<0.001)). additionally, after the intervention, the erigo group showed a greater gait speed (p=0.003), while the visualization group exhibited a higher level of tension in the multifidus (p=0.011) and transverse abdominal muscles (p=0.002).

Eligibility criteria:
inclusion criteria: * 1) patients 6-8 weeks post-stroke, 2) aged 38-85 years, mean, 3) males and females, 4) walking with or without assistance (modified rankin scale = 3), 5) with slight neurological deficits (nihss ≤7). exclusion criteria: * 1) stroke up to six weeks after the episode, 2) epilepsy, 3) no possibility to sit and stand, 4) persistent deficit of speech and cognitive functions, lack of attention, 5) visual disturbances, 6) depression, 7) high or very low blood pressure, dizziness, malaise.

Keywords: erigo, gait, motor imagery, stroke
acute kidney attack in severe traumatized patients

Conditions: Acute Kidney Injury

Summary: acute kidney injury (aki) is a common complication of severe traumatized patients. the diagnosis is often delayed. the nephrocheck® test allows an earlier assessment of renal stress. the objective of our study is to determine the incidence of risk of aki in severe traumatized patients within the first 24 hours after their admission to our trauma center. the risk of aki is defined by a nephrocheck® test \>0.3


Eligibility criteria:
inclusion criteria: * age \>18 years * trauma patients with iss ≥15 * patient admitted to the resuscitation bay of edouard herriot hospital exclusion criteria: * anuric patient * opposition of the patient (or a trusted person) to participate * pregnant or lactating woman * age \<18 years
incidental cancer in gallbladder surgical specimens focus on elderly patients

Conditions: Pathology

Summary: causes such as long-term stones and polyp are thought to play a role in the etiology of gallbladder cancer. the routine histopathological examination provides the detection of incidental gallbladder cancers. it should be remembered that acute or chronic cholecystitis accompanied by the thicked wall and a prolonged history of gallstones may be the cause of malignancy, especially in elderly patients.

the investigators aimed to incidental gallbladder cancer and compare other pathology results with elderly patients.

Eligibility criteria:
inclusion criteria: * acute cholecystectomy * elective cholecystectomy exclusion criteria: * lack of data * incidental cholecystectomy, * cholecystectomy secondary to trauma * cholecystectomy secondary to malignancy

Keywords: cholecystectomy cholecystitis cholelithiasis gallbladder neoplasms histopathology surgical procedures
the evaluation of balanced salt solution during cataract surgery

Conditions: Fuchs Dystrophy; Cataract

Summary: this study aims to identify if the use of bss plus® sterile intraocular irrigating solution as an irrigation solution leads to improved corneal outcomes vs bss® sterile irrigating solution in more compromised corneas.


Eligibility criteria:
inclusion criteria 1. adults, 22 years of age or older, with bilateral visually significant cataracts. 2. subjects with fuch's dystrophy that present with: 1. nonconfluent and confluent guttata; and/or 2. cct \> 580 microns. 3. unremarkable systemic health but inclusive of controlled type ii diabetes and hypertension 4. ability to comprehend and sign a statement of informed consent. 5. ability to complete all required postoperative visits. 6. willingness to use at least one medically acceptable form of birth control throughout the duration of study participation. (for female subjects of childbearing potential only). exclusion criteria 1. planned implantation of multifocal intraocular lenses. 2. planned secondary procedure(s) to occur in conjunction with cataract surgery (i.e., goniotomy) 3. history of severe dry eye. 4. retinal and retinal vascular pathologies, age-related macular degeneration 5. uncontrolled systematic diseases, including: hypertension, diabetes, systemic cardiovascular diseases and hematological diseases. 6. autoimmune disease such as rheumatoid arthritis. 7. female subjects of childbearing potential who are pregnant, nursing, planning a pregnancy, or not using a medically acceptable form of birth control.

Keywords: fuchs corneal endothelial dystrophy nuclear sclerosis cataract surgery paired eye arf-23-001
electrophysiologic measures of treatment response in alzheimer disease

Conditions: Alzheimer Disease

Summary: the main purpose of this study is to determine the electrophysiological effects of cholinergic therapy (cholinesterase inhibitors and transdermal nicotine) in alzheimer disease. the attempt will be to locate electrophysiological markers and predictors of cognitive and clinical treatment response.


Eligibility criteria:
patients diagnosed with mild to moderate probable alzheimer's disease (mini-mental state exam scores between 15-27), and normal controls (age generally between 60-85). subjects must either be planning to start daily cholinesterase therapy (e.g. aricept, exelon) or willing to try a transdermal nicotine patch for two 8 hour periods.
cegir 7807: validation of online cohort of egid patients enrolled in rdcrn cegir contact registry

Conditions: Eosinophilic Esophagitis

Summary: the purpose of this study is to validate the online cohort of egid patients enrolled in the rdcrn cegir cr. in order to achieve this objective, the investigators will determine the agreement between self-reported egid information by the enrollees and their physician's report and medical records. all participants enrolled in the rdcrn cegir cr with egids will be invited via email to participate in this study.

all individuals with egid and enrolled in the rdcrn cegir cr will be invited to participate in this survey. as of 04/28, 1567 egid patients have enrolled in cegir cr \[eoe=1,217, eg=56, ege=65, ec=52; multiple diseases=177\] the survey will be conducted through a pre-designed questionnaire. the questionnaire will be sent to participants via an introductory email wherein subjects will be informed about the purpose of this study. the questionnaire will gather self-reported clinical information (such as diagnosis, endoscopic procedures, histological findings in mucosal biopsies, and therapeutic plan). consent will be obtained from participants to contact their physicians and allow their physicians to share relevant clinical information from their medical records. physicians identified by participants will be emailed a website link which will take them to a questionnaire. this questionnaire is designed to gather relevant information as documented in the patient's clinical records. physicians will be able to submit the information online. it is anticipated that responding to this questionnaire would take less than 10 minutes of their time.

Eligibility criteria:
inclusion criteria: * enrolled in the rdcrn cegir contact registry, and with internet access. * diagnosis of egid (eoe, eg, ege, ee and/or ec) * age: all ages. parents/guardian of children \< 18 years of age will respond to the questionnaire on behalf of their child. exclusion criteria: * inability to provide informed consent and complete survey * unaffected family members of egid patients * european union participants who did not complete general data protection regulation requirements.

Keywords: eosinophilic gastrointestinal disorders
radiofrequency ablation of malignant pulmonary nodules

Conditions: Neoplasms; Carcinoma

Summary: the objective of this study is to evaluate the outcomes of radiofrequency ablation in the treatment of patients with malignant pulmonary nodules（not exceed 3cm ）who are not suitable candidates for or refuse surgical resection.

percutaneous radiofrequency ablation (rfa) is a minimally invasive technique widely used to treat solid tumors. patients with malignant pulmonary nodules will undergo a series of ct- guided percutaneous rfa procedures. during the procedures，percutaneous needles will be inserted into the target tissues under ct guidance，the needles deliver thermal energy and then destroy the tumors by causing coagulation necrosis via tissue heating. the purpose of this study is to assess the effectiveness and safety of rfa in pulmonary nodules （maximum tumor diameter ≦30 mm） was 10 mm apart from the big trachea, primary bronchi, esophagus, great vessels，heart and pleura. preoperative and postoperative evaluations，including recent laboratory tests evaluated and imaging studies reviewed，will be performed both before and after the procedures.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed malignant pulmonary nodules. 2. patients refuse or are not suitable for surgical resections. 3. 1-3 pulmonary nodules , with a maximum tumor diameter ≦30 mm. 4. minimum distance of nodules are at least 10 mm apart from the surrounding tissues as big trachea, primary bronchi, esophagus, great vessels，heart and pleura. exclusion criteria: 1. patients who has uncorrectable coagulation disorders, severe heart or pulmonary failure, or uncontrolled infections. 2. with extensive extrapulmonary or intrapulmonary metastasis. 3. have taken anticoagulant as aspirin in one week. 4. target nodules nearby pleura or other important hilum and mediastinum structures. 5. with metal implants are adjacent to the target tissues which will be covered with ablation area.

Keywords: pulmonary lung cancer carcinoma nodule malignant radiofrequency ablation rfa
three-dimensional assessment of facial alterations induced by dental prostheses

Conditions: Soft Tissue

Summary: validation of the use of a facial scanner for assessment of modifications caused by the use of dental prostheses and determination of discrepancies related to conventional measurements with digital caliper.

3 dimensional evaluation of lip support by the use of full arch impplant supported rehabilitations with the use of a facial scannner. determination of discrepacies between the obtained facial scan and conventional measurements made by a digital caliper on the face.

Eligibility criteria:
inclusion criteria: * patients rehabilitated with full implant supported upper dental prostheses. exclusion criteria: * patients without beard, facial deformities, earrings or braces.

Keywords: imaging, three-dimensional technology, dental accuracy extra-oral scanner