Kornimate/medical-research-clean huggingface dataset:
hepatitis b virus infection in immunized children with hbsag-positive parents

Conditions: Hepatitis b Virus Infection

Summary: hepatitis b virus (hbv) infection is a major public health problem facing the world, with more than 2 billion people infected with hbv. there are more than 400 million chronic carriers, and 75% of carriers live in the asia pacific region. the mother-to-child transmission route of hepatitis b virus is recognized as one of the most important routes of transmission, and recent studies have found that fathers who are carriers of hbv may also be one of the risk factors for hbv infection in children, but as far as the investigators know. therefore, as a high-population area in china, the purpose of this study is to investigate the prevalence of hbv infection in this population.

hepatitis b virus (hbv) infection is a major public health problem facing the world, with more than 2 billion people infected with hbv. although since 1986 the world health organization (who has reduced the incidence of hepatitis b virus-related chronic liver disease, cirrhosis and hepatocellular carcinoma by incorporating hepatitis b vaccination into routine vaccination programmes for infants and adolescents, there are more than 400 million chronic carriers, and 75% of carriers live in the asia pacific region. occult hepatitis b virus infection (obi) is hbv surface antigen negative, but hbv dna can be detected by pcr. although the clinical consequences of obi have not yet been fully determined, recent studies have shown that obi may cause hbv-related diseases such as hepatitis b, cirrhosis, hepatocellular carcinoma, or aggravation or aggravation, and patients who receive immunosuppression through organ or blood transfusion. obi reactivation has occurred. the protective effect on humans after vaccination with hepatitis b vaccine has the investigator sakened over time, and anti-hbs-negative children may have a higher risk of hbv infection due to loss of protection. the mother-to-child transmission route of hepatitis b virus is recognized as one of the most important routes of transmission, and recent studies have found that fathers who are carriers of hbv may also be one of the risk factors for hbv infection in children, but as far as the investigators know, only studies in taiwan and other places have reported studies on hbv infection in children with hbv-infected mothers, and no research has focused on the effects of fathers' hbv positivity on children. therefore, as a high-population area in china, the purpose of this study is to investigate the prevalence of hbv infection in this population.

Eligibility criteria:
inclusion criteria: * the father or (and) mother is hbv-infected (pre-pregnancy or present)； * children is vaccinated with hepatitis b vaccine after birth; exclusion criteria: * children with hbv infection; * participants agreed to undergo clinical follow-up studies.
virtual reality-based exercise in cancer patients

Conditions: Distorted; Balance; Motor Deficit

Summary: the aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in cancer patients. the investigators hypothesize that the virtual reality-based balance training intervention will improve balance and gait performances in cancer patients compared to a control group receiving usual care only.


Eligibility criteria:
inclusion criteria: * ability to ambulate without assistance * willingness to provide informed consent * cancer * neuropathy related to chemotherapy exclusion criteria: * severe neurologic, cardiovascular, metabolic, or psychiatric disorders * severe visual impairment * cognitive impairment
assessment of bullying in children

Conditions: Problematic Behavior in Children

Summary: the specific aims of this study are: * to determine the prevalence of bullying in children who present to the ed with behavioral symptoms * to assess mental health diagnoses and their relationship to type, severity and frequency of bullying behaviors, as well as demographic and psychosocial correlates (socioeconomic status, stress and support) and their relationship to type, severity and frequency of bullying (bullies versus victims). * to explore the attitudes, values, triggering events and potential solutions using qualitative methods * to gain greater insight into the patient experience and perceptions of the bullying events

this is a mix method study which has both qualitative and quantitative components. * data collection sheet * qualitative measurement * quantitative measurement * data collection sheet 1. demographic information (date of birth, gender, race/ethnicity) 2. assessment of socioeconomic status (type of insurance, zip code, parent education level, parent type of work) 3. child physical attributes (appearance, weight, height, percentiles \& bmi, assisted devices, disabilities) 4. academic performance (whether grades are age appropriate, previous grade results 5. extra-curricular activities (questions include do you participate in sports? are you member of any sport team? are you member of any club?) qualitative measurement in order to understand bullying and victimization, a brief qualitative interview will be conducted by the principal investigator and his team. these questions may provide insights into the dynamics of bullying. quantitative measurement following measurement scales will be used in the assessment of children with bullying bullying → olweus bullying questionnaire child behavior → achenbach child behavior checklist stress, life events and adversities → adolescent perceived events scale (apes) social support → child and adolescent social support scale (malecki 2000) social status → macarthur scale of subjective social status family structure → a documentation of family structure and dynamics mental health status → psychiatric evaluation

Eligibility criteria:
inclusion criteria: * children with psychiatric or behavioral problem(s) age 8-18 years referred from the school to the ed * parents willing to provide informed consent and child providing assent exclusion criteria: * actively violent behavior * child abuse * parents or children refuse to participate

Keywords: bullies bully victims psychiatric symptoms
trial of theracurmin for patients with amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: this will be a 6-month, widely inclusive, virtual, single-center, open-label pilot trial utilizing a historical control group.

this will be a 6-month, widely inclusive, virtual, single-center, open-label pilot trial utilizing a historical control group. following informed consent and screening, participants with als will take theracurmin 1 capsule (90mg) twice daily for 6-months. treatment with the theracurmin and all study outcome measures and labs are being performed exclusively for research purposes. collected data includes saliva and stool microbiome sampling, adverse events, concomitant medications, weight and height, theracurmin treatment evaluations, and thrive questionnaires. participants will be asked to register on the website patientslikeme.

Eligibility criteria:
inclusion criteria: * male or female, aged at least 18 years. * sporadic or familial als diagnosed as possible, laboratory-supported probable, probable, or definite as defined by revised el escorial criteria. * patient is able to understand and express informed consent (in the opinion of the site investigator). * patient has access to the internet on a desktop computer, laptop, or tablet and has a working email address. * patient or caregiver is willing and able to use a computer and enter data on a secure website. * patient is able to read and write english. * patient is expected to survive for the duration of the trial. * women must not be pregnant (will have evidence of a negative pregnancy test obtained by local physician within past 7 days or be post-menopausal) * women must not be able to become pregnant (e.g., post-menopausal, surgically sterile, or using adequate birth control methods) for the duration of the study and three months after study completion. adequate contraception includes: abstinence, hormonal contraception (oral contraception, implanted contraception, injected contraception or other hormonal contraception, for example patch or contraceptive ring), intrauterine device (iud) in place for ≥ 3 months, barrier method in conjunction with spermicide, or another adequate method. exclusion criteria: * patient is taking other experimental treatments for als (those that are part of an active research study). * prior side effects from curcumin or turmeric containing products * patient has a medical or psychiatric illness that could in the investigator's opinion interfere with the patient's ability to participate in this study. * pregnant women or women currently breastfeeding. * life expectancy shorter than the duration of the trial. * taking an antiplatelet agent or anticoagulant (due to the theoretically increased risk of bleeding from curcumin products).
peer to peer mentoring: facilitating individuals with early inflammatory arthritis to manage their arthritis - peer mentor training

Conditions: Early Inflammatory Arthritis; Chronic Disease

Summary: inflammatory arthritis (ia) is a major cause of long-term disability. peer support may be a solution to the common problem of delayed treatment. early peer support may result in improved use of therapy, higher self-efficacy, reduced anxiety, and improved coping in the first two years post-diagnosis. this study involves the development and testing of a peer mentor training initiative as one part of an intervention study for people with early ia (eia). peer mentors will be trained and assessed to provide one-on-one support (information, emotional, feedback) to individuals who have recently been diagnosed with ia. this is one part of an intervention study. the other part is called peer to peer mentoring: facilitating individuals with early inflammatory arthritis to manage their arthritis - peer mentoring program.


Eligibility criteria:
inclusion criteria: * to become a peer mentor are: 1. diagnosis of ia from a physician 2. disease duration more than 2 years and managing well 3. currently using medications (dmards/biologics) to treat arthritis 4. have completed an arthritis self-management program (asmp) provided by the arthritis society and/or similar program and/or have sufficient knowledge and experience with teaching or providing mentoring support to an individual living with a chronic disease 5. able to participate in two approximately 5-hour training workshops 6. able to take part in ongoing assessment/evaluation activities (self-report questionnaire, interviews, observation, study activity log) 7. able to commit to the duration of the research study 8. willing to provide ongoing one-on-one support to an individual newly diagnosed with ia 9. 18 years of age or older 10. able to speak, understand, read and write english exclusion criteria: * do not meet inclusion criteria

Keywords: early inflammatory arthritis chronic disease peer support peer mentor peer counselling
daptomycin as antibiotic prophylaxis of sternal wound infections

Conditions: Wound Infection

Summary: the purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.


Eligibility criteria:
inclusion criteria: * age between 18-80 * written informed consent (ic) exclusion criteria: * pregnant and lactating women * patients operated for a transplantation * patients with a increased myopathy risk * patients with a creatinine clearance \< 30ml/min; patients on hemodialysis * patients after a previous sternotomy * treatment with any antibiotics 14 days prior study start * treatment with daptomycin or cefuroxime within 3 month prior study start

Keywords: prophylaxis antibiotic sternotomy heart-lung machine
turkish validity and reliability of the tampa scale for kinesiophobia for temporomandibular disorders

Conditions: Temporomandibular Joint Disorders

Summary: objective: the aim of this study is to evaluate the validity and reliability of the turkish version of the 'the tampa scale for kinesiophobia for temporomandibular disorders (tsk-tmd)' questionnaire used to assess kinesiophobia in temporomandibular joint disorders. method: the "tampa kinesiophobia scale in temporomandibular disorders" (tsk-tmd), which consists of 12 item, was adapted to turkish with the translation and back-translation method. 111 patients (75 females, 36 males) who had been diagnosed with temporomandibular joint for at least 6 months and diagnosed as temporomandibular joint disorder were participated to fill out the questionnaire. in the present study, participants were assessed with the temporomandibular joint disorders evaluation form, turkish tsk-tmd-12 item, visuel analogue scale (vas) and pain catastrophizing scale (pcs). the internal consistency and test-retest reliability with a 3-5 days time were used to evaluate the reliability of the tsk-tmd. the reliability of the corelatıon was checked with pcs. construct validity was assessed based on conﬁrmatory factor analysis (cfa).

we used turkish tsk-tmd-12 item, visuel analogue scale (vas) and pain catastrophizing scale (pcs) questionnaires in our study.

Eligibility criteria:
inclusion criteria:: * volunteer participation in the study, between 18 and 65 years old, * having symptoms for at least 6 months, * being literate, and having communication to understand and answer questions. exclusion criteria: * toothache * cognitive impairment affecting their ability to understand and complete the study questionnaire
a trial to assess the efficacy and safety of tev-53408 in adults with celiac disease

Conditions: Celiac Disease

Summary: the primary efficacy objective of the trial is to assess the ability of tev-53408 to attenuate gluten-induced enteropathy in adults with celiac disease. the primary safety objective of the trial is to assess the safety of tev-53408 in adults with celiac disease. a secondary objective is to further assess the efficacy of tev-53408 in adults with celiac disease. the expected trial duration per participant is approximately 86 weeks.


Eligibility criteria:
inclusion criteria: * diagnosis of celiac disease at least 12 months prior to screening * on a gluten-free diet for at least 12 months prior to screening * women must not be pregnant, lactating, breastfeeding, or planning pregnancy during the trial period * male participants (including vasectomized) with women of child-bearing potential partners (whether pregnant or not) must use condoms and also agree not to donate sperm for the designated period note - additional criteria apply, please contact the investigator for more information. exclusion criteria: * a diagnosis or suspicion of refractory celiac disease * history of severe celiac-related symptoms following gluten exposure that require acute medical care or intervention of a health care professional * any other gastrointestinal disease or condition that may interfere with the assessment of celiac disease * current or history of malignancy or treatment of malignancy in the last 5 years, excluding treated basal cell carcinoma * pregnant or lactating woman, or plans to become pregnant during the trial; any man who is considering fathering a child or donating sperm during the trial * a history of chronic alcohol or substance abuse disorder within the previous 2 years. * an active infection(s) requiring treatment with intravenous (iv) anti-infectives (antibiotics, antivirals, antifungals) within 30 days prior to screening or oral anti-infectives (antibiotics, antivirals, antifungals) within 14 days prior to screening * received or intends to receive any live vaccine within 4 weeks or any non-live vaccine 2 weeks prior to investigational medicinal product administration. note- additional criteria apply, please contact the investigator for more information
noninvasive neuromonitoring of surgery of the thoracic aorta

Conditions: Cardiopulmonary Arrest; Aortic Aneurysm, Thoracic; Aortic Diseases; Coronary Artery Disease

Summary: the aim of this prospective, explorative study of noninvasive neuromonitoring was to search potential and practical methods associated with neurological outcome in the perioperative and immediate postoperative setting of surgery of the thoracic aorta. these methods include abbreviated eeg monitoring, near-infrared spectroscopy, transcranial doppler ultrasound and biochemical markers associated with neuronal damage.

for the purpose of this study, 30 patients undergoing aortic surgery via a median sternotomy (n=29; 97%) or left thoracotomy (n=1; 3%) and cardiopulmonary bypass with deep hypothermic cardiac arrest were recruited. all patients were operated under deep hypothermia and circulatory arrest, with optional selective cerebral perfusion during circulatory arrest. active patient recruitment started from september 2007 and ended in may 2011. all patients were monitored with a bilateral fronto-temporal four channel abbreviated eeg, a bilateral frontal two-channel near-infrared spectroscopy, postoperative transcranial doppler ultrasound evaluation of median artery circulation and postoperative biochemical neuromarkers. the study montage was set up by a dedicated research nurse, who also performed the transcranial doppler measurements. the neuromonitoring data were not used at the time to guide therapeutic decisions, with the exception of near-infrared spectroscopy monitoring.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective or emergency surgery on the thoracic aorta (study group) or coronary heart disease (control groups) * informed consent from patient or next of kin exclusion criteria: * age under 18 years

Keywords: aortic diseases aortic aneurysm electroencephalography near-infrared spectroscopy transcranial doppler ultrasonography cardiopulmonary arrest hypothermia, induced
analgesic effect of quadratus lumborum block in laparoscopic hemicolectomy

Conditions: Post Operative Pain

Summary: comparison of the effectiveness: quadratus lumborum (ql) block by levobupivacaine with placebo.

all patients will receive standard anaesthesia using fentanyl, protocol, cisatracurium and sevoflurane. prevention of nausea and vomiting is performing using apfel score. all patients will receive post operative multimodal analgesia using paracetamol, ketoprofen, tramadol, and trimeperidine if numerical rating scale \> 3 the study assumes use of ql block by levobupivacaine.in comparison with placebo in order to demonstrate the effectiveness of ql block during the operation.

Eligibility criteria:
inclusion criteria: * patients who have undergone left-sided or right-sided laparoscopic hemicolectomy. * patient's willingness and ability to sign an informed consent document exclusion criteria: * allergy to local anesthetics * chronic pain syndrome and associated opioid use. * coagulopathy * uncontrolled diabetes mellitus * physical status classification system scale above 3 * diseases associated with the pathology of the hypothalamus * diseases associated with the pathology of the pituitary gland * diseases associated with the pathology of the adrenal glands
outcome of specific ige level in children with ige-mediated wheat allergy after stop using wheat containing skin care

Conditions: Wheat Allergy; Children

Summary: wheat allergy is increasing in thailand. some studies show that cutaneous exposure of allergen may cause allergy and there are many wheat containing skin care products that are over-the-counter. so the purpose of our study is to determine level of specific immunoglobulin e antibodies to wheat and omega-5 gliadin in wheat allergy patients after stop using wheat containing skin care products.

all children in this study were sensitized to wheat. each patient was clinically evaluated, with focus on wheat allergy by medical history, medical examination included skin status (suspected atopic dermatitis or not). blood sample was taken for baseline determination of immunoglobulin e antibodies to wheat and to omega-5 gliadin. transepidermal water loss was examined in case with atopic dermatitis. the primary outcome was the specific immunoglobulin e antibodies to wheat and omega-5 gliadin in case that stop using wheat containing skin care product and case that continue using products.

Eligibility criteria:
inclusion criteria: * children age 1 to 18 years * history of ige-mediated wheat allergy exclusion criteria: * parents refused to sign the consent * severe atopic dermatitis * on oral immunothery * severe ige mediated reaction after using wheat containing skin care product

Keywords: wheat allergy skin sensitization specific ige wheat containing skin care
effect of accelerated rth in squamous cell carcinoma in head and neck

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: evaluation of the efficacy of the accelerated radiotherapy in squamous cell carcinoma of head and neck

* hnscc is the sixth most common cancer worldwide, with 890.000 new cases and 450.000 deaths in 2018. * the incidence of hnscc continues to rise and is anticipated to increase by 30% (that is, 1.08 million new cases annually) by 2030. * squamous cell carcinoma constitutes 90% of all head and neck cancers and it predominates in males. * risk factors such as cigarette consumption and alcohol consumption, are well established. * treatment decisions are guided by clinic-pathologic factors such as age and stage. * treatment of the majority of patients with hnscc requires multimodality approaches. * radiotherapy or surgery alone can be considered as the standard treatment modality for patients having early head and neck squamous cell carcinoma. * when conventionally fractionated radiotherapy is used, long-term tumor control can be achieved in less than 30% of patients with advanced head and neck carcinomas.

Eligibility criteria:
inclusion criteria: * patients of (18 up to 75 years of age) * performance status of 0-2 according to ecog scale. * patients with no prior chemotherapy, radiotherapy or surgery except for biopsy. exclusion criteria: * patients with previous irradiation to head and neck. * pregnant or lactating women. * patients with impaired heart or lung diseases.
pharmacokinetic study of antibiotics in patients assisted by extracorporeal membrane oxygenation (pharmecmo)

Conditions: Extracorporeal Membrane Oxygenation; Sepsis; Intensive Care Unit; Antibiotics

Summary: the pharmecmo study is a pilot, prospective, pharmacokinetic study, conducted in a cardiac surgery intensive care unit of 18 beds. optimization of antibiotic therapy for extracorporeal membrane oxygenation (ecmo) patients remains a pharmacological challenge. clinical studies suggest that individualized dosing strategies and therapeutic drug monitoring could facilitate the achievement of adequate antibiotic concentration. the objective of this pilot study was to observe the pharmacokinetic characteristics of commonly used antibiotics in intensive care for patients treated with extracorporeal membrane oxygenation.


Eligibility criteria:
inclusion criteria: * age \> 18 years * extra corporeal membrane oxygenation treatment * parenteral antibiotherapy for known or suspected sepsis * informed consent exclusion criteria: * refusal of participation * pregnancy * burned patient * steady state conditions not reached * non-intravenous administration of antibiotherapy

Keywords: extracorporeal membrane oxygenation sepsis antibiotics pharmacokinetic intensive care unit