Kornimate/medical-research-clean huggingface dataset:
the comparison of tunnel morphology and graft healing in anterior cruciate ligament reconstructions using peroneus longus and hamstring tendons

Conditions: Anterior Cruciate Ligament Rupture

Summary: 1. comparison of the grafts using magnetic resonance imaging (mr) to determine whether their maturation and bone integration are different, 2. comparison of the grafts using computerized tomography (ct) to determine whether their effects on the tunnels opened in cruciate ligament reconstruction surgeries are different, 3. in the event that graft healing and effects on the tunnels differ between grafts, determination of whether these differences are related to patient clinics,

the project method; patients who will be operated with 2 different grafts used in anterior cruciate ligament surgeries will be included in 2 different randomized groups of 29 people (hamstring and peroneus groups) determined by obtaining their informed consent before the surgery and then, 1. the maturation of the grafts will be measured and compared with the snq (signal/noise quotient) value and the graft-bone integration with the si (signal intensity) value with the magnetic resonance (mr) to be taken at the 1st year controls after the surgery, 2. changes in tunnel morphology; the volume of the tunnels will be measured with the computerized tomography (ct) imaging method to be taken prospectively within the first week after the surgery date and 1 year after the surgery date and the changes within 1 year will be calculated by comparing them. 3. in the outpatient clinic follow-ups of both groups; knee laxity will be obtained with lachman, anterior drawer and pivot shift tests and knee scores and activity levels will be obtained using ikdc, lysholm, marx scales and it will be examined whether these data are related to snq, si and tunnel expansion.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 45 years. * bmi in the range of 18 to 28. * diagnosed with an anterior cruciate ligament (acl) injury preoperatively confirmed by mri. * patients for whom it is deemed appropriate to harvest ipsilateral hamstring tendons or peroneus longus tendon for use as a graft. exclusion criteria: * history of previous surgery on the affected knee or ankle. * presence of multiple ligament injuries in the affected knee. * diagnosis of advanced osteoporosis. * acl injuries that occurred more than 12 months prior to surgery. * evidence of unstable meniscal injury on preoperative mri, which may alter the postoperative rehabilitation process. * evidence of unstable meniscal injury on preoperative mri, which may alter the postoperative rehabilitation process.

Keywords: anterior cruciate ligament peroneus longus tendon hamstring tendon snq tunnel widening
study to examine the effects of atp supplementation on muscle excitability and reaction time during and following a repeated sprint bout

Conditions: Muscle Fatigue Caused by Repetitive Muscle Exercise

Summary: we hypothesize that adenosine-5'-triphosphate (atp) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. this will give researchers a better understanding of the mechanism by which atp supplementation can augment power, especially under high fatiguing conditions.

healthy participants of similar training status as previously tested will be enrolled into the study. the participants will be randomly assigned to either placebo supplementation or to 400 mg atp per day for 14 days. the supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. testing will be performed at baseline and after the 14 days of supplementation. ten successive sprints will be conducted on the wingate apparatus as this has been previously demonstrated to decrease muscle excitability. after the sprints, muscle excitability, reaction time, and vertical jump power will be measured. in addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. it is expected that atp supplementation may help maintain muscle excitability and power after the successive sprint sessions.

Eligibility criteria:
inclusion criteria: * agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. * must not have taken performance enhancing supplements for at least 3 months prior to the study start, * must be a non-smoker. * must not be taking amino acid supplements. * must not be using anabolic or catabolic hormones. * must not be taking any medications known to influence variables to be measured in the study. exclusion criteria: * will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. * has taken performance enhancing supplements for at least 3 months prior to the study start, * is currently a non-smoker. * is currently taking amino acid supplements. * is currently using anabolic or catabolic hormones. * is currently taking medications known to influence variables to be measured in the study.
predictors favoring the role of exclusive enteral nutrition in active crohn's disease

Conditions: Crohn's Disease; Enteral Nutrition

Summary: to idetify the factors favoring the use of enteral nutrition would be helpful to select preferred patients suitable for enteral nutrition.

crohn's disease (cd) is a chronic, transmural inflammatory disorder affecting the whole alimentary tract from mouth to anus. over the past decades, the incidence of cd is either high and stable or low but rising in the worldwide. although the precise etiopathogenesis of cd remains unknown, a number of lines of evidence showed that inappropriate diet was one of the reasons responsible for the onset of cd, and diet therapy has been gaining increasing attention in the therapeutic work-up of cd. due to reduced intake and high intestinal losses, over three quarters of cd patients would suffer weight loss. involvement of small bowel in cd patients made their nutrition status much poorer than ulcerative colitis (uc) patients. therefore, nutrition support is of great value in the management of cd. it is widely accepted that enteral nutrition could help pediatric cd patients to reach clinical and endoscopic remission, with similar efficacy but less side effects than corticosteroids. however, the value of enteral nutrition in adult active cd is still controversial, with an unstable remission rates ranging from 8% to 100%. varied characteristics and compliance of enrolled patients might explain this wide range. considering this, idetification of factors favoring the use of enteral nutrition would be helpful to select preferred patients suitable for enteral nutrition. in this study, we will observe the role of enteral nutrition in active adult cd. the age, gender, serum crp, albumin, fecal calprotectin, nutritional risk screening 2002 (nrs2002), involved intestinal segments and other items will be correlated with the changes of crohn's disease activity index (best cdai) and crp in order to idetify the factors favoring the use of enteral nutrition.

Eligibility criteria:
inclusion criteria: * diagnosed as active cd based on clinical presentation, endoscopic and pathology results * has the willing to receive enteral nutrition exclusion criteria: * no exposure to glucosteroids or immunosuppressions * complete intestinal obstruction
topical amethocaine gel for intramuscular injection in term neonates

Conditions: Pain

Summary: this study will examine the efficacy of topical amethocaine gel (ametop) in decreasing the pain response in term neonates subjected to intramuscular injection for administration of vitamin k. study hypothesis: we believe that topical amethocaine gel will be superior to placebo in decreasing the pain from intramuscular injection in term neonates.

this randomized controlled trial will assess the efficacy of topical amethocaine gel (ametop) compared with placebo (eucerin plus) in decreasing the pain response in term neonates subjected to intramuscular injection for administration of vitamin k. neonatal pain response between groups will be assessed using the neonatal facial action coding system (nfcs) which is currently the gold standard for infant pain assessment, latency to first cry and cry duration. parents' (father) perception of infant's pain will be assessed using a visual analogue scale (vas) when possible. neonates will be randomized to receive either amethocaine gel or identical appearing placebo administered locally at the injection site (the upper part of the neonate's thigh) using a pre-prepared syringe 30 minutes prior to the administration of vitamin k. the gel or placebo will be covered using a saran wrap. each neonate will be videotaped during the procedure. parents (father) will be present during the procedure (observing) so that they (he) can assess their neonate's pain response using vas.

Eligibility criteria:
inclusion criteria: 1. term neonates \> 37 weeks and 2. birth weight \> 2500 grams (appropriate for gestational age - aga) - exclusion criteria: 1. neonates with major congenital anomalies 2. neonates with known neurological abnormalities (antenatally diagnosed) 3. neonates who require admission to the neonatal intensive care unit at birth

Keywords: infant,newborn topical anesthesia intramuscular injection
telemonitoring system for improving continuity of care in patients with chronic coronary syndrome (telsincorc)

Conditions: Chronic Coronary Syndrome

Summary: in a randomized clinical trial, a comprehensive telerehabilitation system with a prolonged follow-up strategy demonstrated superiority over a control group with centre-based cardiac rehabilitation in terms of physical activity, vo2 max, adherence to a mediterranean diet, lipid particle profile and cost-effectiveness. the aim of this study is to demonstrate an extension of the benefit to patients with chronic coronary syndrome in primary care.

the patients who have suffered an acute coronary event have a recurrence rate of 2.5% to 15.5% person-years during the first year. control of cardiovascular risk factors can improve the prognosis of these patients. following the results of a clinical trial to validate a comprehensive monitoring system called cardioplan, with a prolonged monitoring strategy, the investigators aim to conduct a study in patients with chronic coronary syndrome in the primary care setting comparing a control group with standard follow-up and a 10-month telemonitored group. four primary care centres will participate. two health centres attend mainly a population with a medium-high upper socioeconomic level and the other two mainly a population with a medium-low socioeconomic level. a total of 160 subjects are expected to be included in the follow-up, with 80 subjects in each study group. the primary endpoint is to demonstrate that telemonitored follow-up improves functional exercise capacity compared to usual care, by assessing the distance in meters covered in the 6-minute walk test.

Eligibility criteria:
inclusion criteria: * signed informed consent * patients after more than one year of an acute coronary syndrome of both sexes. * age equal to or less than 72 years. exclusion criteria: * refusal of informed consent * advanced biological age. * kidney failure (gfr \< 30ml/min/1.73 m2). * liver failure (got \>2 times normal value). * ejection fraction less than 50%. * uncontrolled blood pressure (\>140/90 mmhg). * uncontrolled heart failure. * dissecting aortic aneurysm. * uncontrolled ventricular tachycardia or other dangerous ventricular arrhythmias. * aortic or mitral valve disease. * recent systemic or pulmonary embolism. * active or recent thrombophlebitis. * acute infectious diseases. * uncontrolled supraventricular arrhythmias or tachycardia. * repeated or frequent ventricular ectopic activity. * moderate pulmonary hypertension. * ventricular aneurysm. * uncontrolled diabetes, thyrotoxicosis, myxedema, * conduction disorders such as: complete atrioventricular block. left bundle branch block. * wolf-parkinson-white syndrome. * fixed rate pacing. * severe anaemia. * psychoneurotic disorders. * neuromuscular, musculoskeletal and arthritic disorders that may limit activity. may limit activity.

Keywords: mobile health chronic coronary syndrome cardiac rehabilitation telerehabilitation secondary prevention exercise
efficacy of zinc towards the outcome on children with sepsis

Conditions: Sepsis

Summary: sepsis is a life-threatening organ failure induced by a compromised immune response to infection. sepsis is a leading cause of morbidity and mortality (50-60%) in children treated in inpatient and critical care units. children suffering from immunodeficiency have a higher mortality rate. several studies in recent years have revealed that zinc homeostasis may be a significant role in the prevention of sepsis. it was important to conduct this study to determine the efficacy of zinc in children suffering from sepsis.

this research is a randomized controlled trial with parallel study design conducted in makassar, south of sulawesi, indonesia from february to may 2024. this study was conducted on children with a diagnosis of sepsis. patients were divided into two groups, namely zinc group which received standard therapy with zinc and placebo group which received standard therapy with placebo. the inclusion criteria were children aged 1 month to 18 years, diagnosed with sepsis, and parents/caregivers willing to participate their children in this study. patients with diarrhea, malnutrition, acute kidney injury due to kidney illness, hematological diseases, patients who have received zinc in the previous month, and patients who leave on their own request are all excluded from this study. patients who not taking medication for up to three days in a row, either due to forgetfulness or self-determination, or due to side effects, and being unable to complete the study before the end date for various reasons, including death were declared dropouts. researchers will provide informed consent to parents/caregivers of children who met the research criteria. anamnesis, general physical examination, and clinical also laboratory parameters were examined on day 0, 8, and 11 after zinc and placebo supplementation, such as; degree of consciousness, use of mechanical ventilators, p/f ratio, map, lactate levels, serum leukocyte and platelet counts, crp and procalcitonin levels, lactate levels, sepsis progression, and mortality rates. the research results are recorded in a research form and the data is grouped and spss version 21.0 software is used for data analysis. a p value \<0.05 was considered for statistical analysis. this study was approved by the ethics and research committee of the faculty of medicine, at hasanuddin university.

Eligibility criteria:
inclusion criteria: - children aged 1 month to 18 years with diagnosis of sepsis exclusion criteria: * diarrhea * malnutrition * acute kidney injury due to kidney illness * hematological diseases * have received zinc in the previous month * leave on their own request dropping out criteria: * not taking medication for up to three days in a row * death

Keywords: sepsis zinc
non-invasive measurement of hemoglobin in retinal arteries

Conditions: Healthy Subjects; Anemia

Summary: the purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries.

to our knowledge no tool exists that allows for direct collection of hemoglobin data in the eye. in many eye diseases (especially diabetic and hypertensive retinopathy as well as in retinal vessel occlusions) retinal circulation is modified. knowing hemoglobin concentration on the site of the pathology will give us further information about the pathogenesis of this diseases and may provide a new possibility in therapy. the purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries. healthy volunteers from the eye clinic and pregnant otherwise healthy patients of the gynecological department of the triemli hospital, zurich, as well as anemic gynecological patients that show up for a check-up are included. hemoglobin will be quantified by a blood draw of a cubital vein. using a fundus camera (nidek afc-230) pictures of the fundus will be taken from each study patient. afterwards the study investigator selects a retinal artery of interest which will be used for measuring the hemoglobin concentration. intensity of the green channel of the camera chip is determined with the aid of the law of lambert-beer. absolute hemoglobin concentration is calculated in relation to the vessel volume.

Eligibility criteria:
inclusion criteria: * healthy volunteers * pregnant patients from the triemli hospital that came for a routine check up * anemic patients of the same dept with various gynecological tumors exclusion criteria: * any known retinal eye disease * poor fundus picture quality due to fixtion problems or too small pupil or media intransparency * not willing to participate in a study

Keywords: retinal hemoglobin concentration non-invasive hemoglobin measurement
effect of stellate ganglion block on me/cfs

Conditions: Encephalomyelitis, Myalgic; Chronic Fatigue Syndrome; Chronic Fatigue Disorder; Chronic Fatigue and Immune Dysfunction Syndrome; Myalgic Encephalomyelitis; Postviral Fatigue Syndrome; Systemic Exertion Intolerance Disease; Infectious Mononucleosis-Like Syndrome, Chronic; Chronic Fatigue-Fibromyalgia Syndrome

Summary: the goal of this clinical trial is to study the effects of stellate ganglion block (sgb) in participants with myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs). the main questions it aims to answer are: does sgb treatment improve symptoms of me/cfs (e.g. brain fog, fatigue)? do changes in symptoms go along with changes in blood or saliva? participants will receive a total of six blocks over three weeks (one block on each side, one day apart, per week). prior to treatment and at two points following treatment, participants will complete surveys, take a cognitive (puzzle type) test, and provide blood and saliva for analysis. participants will measure their heart rate daily using a free smart phone app.


Eligibility criteria:
inclusion criteria: * age (18-50 years) * female * me/cfs (ccc and iom criteria) duration less than 4 years at time of study enrollment * confirmed or suspected viral disease prior to me/cfs onset (e.g., sars-cov-2, epstein-barr, influenza) * bmi =18-29 kg/m\^2 * ability to read, write and speak english language exclusion criteria: * prior sgb treatment * allergy to amide local anesthetics (e.g. ropivacaine, bupivacaine) * current anticoagulant use * history of bleeding disorder * history of glaucoma * infection or mass at injection site * anatomical abnormalities in c3-t1 region * current pregnancy * hypertension * diabetes (any type) * thyroid disease * history of neck or throat surgeries * vocal cord problems or paralysis * causalgia/chronic regional pain syndrome (crps) * current cancer diagnosis * diagnosis of guillain-barré syndrome * diagnosis of current moderate or severe substance use disorder * history of neurological disease, seizure, or significant head trauma * conditions or disorders (other than me/cfs) that affect cognitive functioning including stroke, past or present diagnosis of psychosis or psychotic symptoms, diagnosis of bipolar i disorder, or severe depression

Keywords: me/cfs myalgic encephalomyelitis chronic fatigue syndrome stellate ganglion block sgb cervical sympathetic block post-exertional malaise pem exertional intolerance brain fog orthostatic intolerance
restless legs syndrome in people with neuromyelitis optica spectrum disorder

Conditions: Neuromyelitis Optica; Restless Legs Syndrome

Summary: restless legs syndrome (rls) is a neurological movement disorder characterized by uncomfortable and uncontrollable sensations, usually in the legs, that increase at rest, and an urge to move the legs or other affected extremities. the exact cause of rls is unknown, but there are idiopathic and secondary forms of rls associated with various medical conditions such as anemia, pregnancy, uremia, neuropathies, rheumatoid arthritis, parkinson's disease, spinocerebellar ataxia, and neurological disorders such as multiple sclerosis. neuromyelitis optica (nmo) is a severe inflammatory disease of the central nervous system. nmo, once considered a variant of multiple sclerosis, is now recognized as a separate disease entity. in 2004, the water channel protein-specific antibody called aquaporin 4 (aqp4) was found to cause nmo, leading to the identification of nmo as a separate disease. when initially described, the disease was thought to show only necrotic and demyelinating lesions in the optic nerve and spinal cord. it was therefore thought that nmo would preferentially only attack the optic nerves and spinal cord, not the brain. however, over the years, evidence from various studies has proven that various parts of the brain are also affected during the course of the disease. in addition, some patients showing features of the disease were found to be seronegative for anti-aqp4 antibodies. these findings necessitated the need to introduce a new term "neuromyelitis optica spectrum disorders (nmosd)" to describe all the features of the disease. although the feeling of restlessness in the legs is frequently reported as a sensory symptom by people with nmosd, there are limited publications to investigate the relationship between rls and nmosd. the primary aim of the study is to determine the frequency and severity of rls in people with nmosd. the second aim of the study is to compare the presence and severity of rls, sleep quality, daytime sleepiness level, quality of life, fatigue and magnetic resonance imaging (mri) results in people with nmosd. the third aim of the study is to compare the cognitive functions of people with rls positive and negative nmosd. people with nmosd who came to dokuz eylul university medical faculty hospital neurology department ms polyclinic for their routine check-ups, who volunteered to participate, will be included in the study.


Eligibility criteria:
inclusion criteria: * being diagnosed with nmosd by a neurologist * to be willing to participate in the study. exclusion criteria: * diagnosed severe cognitive and/or psychiatric impairment * having any of the conditions known to be associated with rls, such as anemia \[hemoglobin (hb) levels \<12 mg/ml\], pregnancy, uremia, neuropathies, rheumatoid arthritis, and neurological diseases other than nmosd

Keywords: sleep neuromyelitis optica cognitive functions