Kornimate/medical-research-clean huggingface dataset:
effect of the system in the enriched fat metabolism of the child reached mitochondrial cytopathy

Conditions: Mitochondrial Cytopathies Disorders

Summary: the aim of the present study is to compare resting energy expenditure (ree) between normal fat diet (nfd) as a control vs high fat diet (hfd) as a treatment in mitochondrial cytopathies disorders ( mid's ) patients. secondary objectives is to compare diet induced thermogenesis (dit) and body composition between nfd vs hfd. this study is a randomized cross-over study. normal fat diet (ie 10 % proteins, 45 % lipids, 45 % carbohydrates) is the imposed diet at baseline, high fat diet (ie 10 % proteins, 30 % lipids, 60 % carbohydrates is used according to the cross-over design trial. main evaluation criteria is ree and second evaluation criteria is dit both measured by indirect calorimetry ). 36 included mid subjects will be included in this study. main evaluation criteria and second evaluation criteria will be measured at baseline, 1 month, 2 month and 3 month.

ree and dit are measured by indirect calorimetry . the device used is a using an open-circuit ventilated hood system (quark rmr®, cosmed, pavona; italy). the respiration quo- tient (rq) and flow settings are calibrated by reference to alcohol combustion every six months. before each test, the calorimeter is calibrated with a reference gas mixture (5% co2, 95% o2 v/v). expired carbon di- oxide (vco2) and inspired oxygen (vo2) -flows are recorded, as well as the rq. ee is calculated every minute from oxygen consumption (vo2 in ml/min) and carbon dioxide production (vco2 in ml/min) using the weir formula without protein correction. dit is measured during 6 hours after a calibrated breakfast (normal fat diet or high fat diet according to the cross-over design) as 30% of theoric energy intake.

Eligibility criteria:
inclusion criteria: * 5 to 21 years-old children, * children with a proven mitochondrial cytopathy documented on biopsies by histology, histoenzymology, ultrastructure and enzyme assay and/or on body fluids by laboratory markers including lactacidemia, metabolic acidosis, increased csf lactate, lactate/pyruvate and beta-hydroxybutyrate/acetoacetate ratios, paradoxical postprandial ketonemia, alaninemia, citrullinemia, plasma acylcarnitines. * children on the usual diet (30% lipids, 60% glucides and 10% proteins) for at least 1 month. * informed consent of the 2 parents and from the child when in age to express a consent. * child with a social security cover. exclusion criteria: * acute infection (fever \> 38.5°c for more than 6h) within 7 days prior to the study. * disability for understanding and following the protocol * rejection of the study by the patient or failure to comply to the protocol
association of the intrarenal resistance index (ri) of transplanted kidneys with generalized atherosclerosis

Conditions: Renal Transplantation

Summary: cross sectional observational ultrasound study of transplanted kidneys and the carotid artery in consecutive recruited outpatients.


Eligibility criteria:
inclusion criteria: * patients after renal transplantation with stable renal function exclusion criteria: * known impairment of renal function (e.g. acute rejection) * known renal artery or carotid artery stenosis
rhythmic entrainment in bilingual speakers with dysarthria

Conditions: Parkinson Disease; Ataxia

Summary: the objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in spanish-accented speakers of english in two pathology groups: ataxic dysarthria and hypokinetic dysarthria secondary to idiopathic parkinson's disease; and ii) the extent to which speech rate and effort are control parameters of entrainment. these objectives will be achieved with the following specific aims: specific aim 1: determine the effect of three rates of hand gestures and auditory rhythmic cues and the degree to which learning and carry-over occur. specific aim 2: determine the effect of increased speech effort, operationalized as clear speech, and the interaction effect of clear speech with hand gestures and auditory rhythmic cues. specific aim 3: investigate the perception of speech rhythm and its relationship to entrainment.

the objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in spanish-accented speakers of english in two pathology groups: ataxic dysarthria and hypokinetic dysarthria secondary to idiopathic parkinson's disease; and ii) the extent to which speech rate and effort are control parameters of entrainment. these objectives will be achieved with the following specific aims: specific aim 1: determine the effect of three rates of hand gestures and auditory rhythmic cues and the degree to which learning and carry-over occur. specific aim 2: determine the effect of increased speech effort, operationalized as clear speech, and the interaction effect of clear speech with hand gestures and auditory rhythmic cues. specific aim 3: investigate the perception of speech rhythm and its relationship to entrainment. the protocol calls for 12 talkers to participate in a single case experimental design: 6 spanish-accented speakers of english and 6 native english speakers, and each language group consisting of 2 healthy controls, 2 adults diagnosed with ataxic dysarthria and 2 adults diagnosed with hypokinetic dysarthria secondary to idiopathic parkinson's disease. sixty monolingual healthy adult listeners will rate intelligibility, accentedness, and ease of understanding.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic parkinson's disease (4) or dysarthria secondary to ataxia (4) or healthy (4) * monolingual speaker of american english (6) or native speaker of spanish who speaks english with a spanish accent (6) * age 21 or older exclusion criteria: * cognitive impairment that prevents participation in the therapy * fluent speakers of languages other than english or spanish * younger than 21 years

Keywords: speech rhythm speech therapy
foveal cone outer segment resumption to predict visual recovery after macular hole surgery

Conditions: Macular Holes

Summary: spectral domain optical coherence tomography (sd-oct) was used to determine whether the repair of photoreceptor cone outer segment tips defect is significantly correlated with the visual outcomes after macular hole surgery.

spectral domain optical coherence tomography (sd-oct) was used to calculate the mean length of photoreceptor cone outer segment tips (cost) defect on 1, 3, 6, 9, and 12 months after macular hole surgery. the correlation between the mean length of cost defect and the bcva was determined. prognostic factors might have influenced for cost repair was also evaluated by multivariable analysis.

Eligibility criteria:
inclusion criteria: * macular hole patients with surgically-closed hole exclusion criteria: * macular hole patients failed to close hole * presence of retinal diseases including a treated rhegmatogenous retinal detachment, diabetic retinopathy, and high myopia with an axial length \>27.0mm or refractive error \> -8.0 diopters(d). * patients who were not followed at least 6 months

Keywords: spectral-domain optical coherence tomography idiopathic macular hole cone outer segment tips line vitrectomy
effects of wholegrains on children's health (korn)

Conditions: Cardiometabolic Health; Gastro-intestinal Wellbeing; Cognitive Function; Overweight

Summary: korn investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.

the purpose of korn is to investigate the effects of wholegrain oat and rye intake on cardiometabolic health in slightly overweight 8-13-year-old children. moreover, korn aims to investigate effects on body weight and body composition, inflammatory markers, gastrointestinal wellbeing and cognitive function and explore the potential underlying mechanisms through assessment of changes in the children's gut microbiota as well as potential genotype-dependent and sex-specific effects. the study has a randomized controlled cross-over design. in two 8-week dietary periods the children will receive grain products (cereals, breads, pasta etc) with either high or low content of wholegrain from oat and rye in random order. measurements and biological sampling will be performed at 0, 8 and 16 weeks.

Eligibility criteria:
inclusion criteria: * boys and girls 8-13 years of age * be overweight i.e. have a parent-reported bmi of at least +1 standard deviation above the median according to the age and sex-standardized danish growth curves * be healthy * like grain products and eat them daily * speak danish in order to understand the study procedures * at least one parent must read and speak danish, in order to be properly informed about the study procedures * parents must have freezer capacity for 2 weeks bread provision exclusion criteria: * allergy or intolerance to the study foods, including gluten * use of dietary fiber supplements (e.g. husk) or probiotic supplements * dieting or on a special diet * serious chronic illnesses and diseases that may interfere with study outcomes * use of medication that may affect study outcomes, including use of antibiotics the last month * concomitant participation in other studies involving dietary supplements, drugs or blood sampling * living in a household with another participating child

Keywords: children wholegrain cardiovascular risk markers overweight adolescents
monitoring efficacy of radiotherapy in lung cancer and esophageal cancer

Conditions: Lung Cancer; Esophageal Cancer

Summary: lung cancer, one of the malignant tumors which poses a threat to human's health, has increased morbidity and mortality recently. radiotherapy, as one of the common treatments, has important value in clinical application. esophageal cancer, one of the most common digestive system cancers, has poor prognosis and high mortality. esophageal cancer has high aggressive and many patients can't get surgical treatment because of the tumor metastasis at the time of diagnosis.currently, chemoradiotherapy has become one of the standard treatment regimens for patients with unresectable esophageal cancer in national comprehensive cancer network(nccn). so radiotherapy is one of the most important treatments in esophageal cancer. currently, the efficacy evaluation method of radiotherapy is by imaging examination after several courses of treatment. however, new reports suggest that circulating tumor dna(ctdna) has the potential to be an indicator of therapeutic effectiveness and recurrence risk.

circulating free dna (cfdna) can be found dissolved in plasma and serum, at variable amounts. in the case of cancer patients, ctdna is a fraction of the cfdna derived from tumor. currently, the ctdna is widely used in "liquid biopsy" for not only does it carry the same somatic alterations as the tumor itself but also its percentage is correlated with tumor burden. this study will investigate the clinical value of efficacy evaluation and prognosis of ctdna detecting technique in patients with radiotherapy.

Eligibility criteria:
inclusion criteria: * patients with histopathological proved lung cancer or esophageal cancer. * candidate for radiotherapy. * no history of prior anti-tumor treatment. * eastern cooperative oncology group (ecog) score 0,1. * being able to receive computed tomography (ct) and magnetic resonance imaging (mri). * blood sample is available for dynamic monitoring. * written informed consent provided. * good compliance in the follow-up. exclusion criteria: * had received radiotherapy, chemotherapy, biotherapy or other treatment that is related to lung cancer or esophageal cancer. * the patients have the sign of any serious or uncontrolled systematic diseases that may have significant impact on the balance between risk and benefit, such as hypertension, infection of hepatitis b, hepatitis c or human immunodeficiency virus(hiv). * with history of alcohol or drug abuse.

Keywords: lung cancer esophageal cancer radiotherapy ctdna
cancer stem cell biomarkers as a predictor of response to trastuzumab in samples from patients with breast cancer previously treated in the nsabp-b-31 trial

Conditions: Breast Cancer

Summary: rationale: studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research trial studies biomarkers as a predictor of response to trastuzumab in samples from patients with breast cancer previously treated in the nsabp-b-31 trial.

objectives: primary * to determine if stem cellness identifies a poor prognostic subgroup of women with early-stage breast cancer who have been uniformly treated with either adjuvant doxorubicin hydrochloride \& cyclophosphamide followed by paclitaxel (the "control arm" of b31), or the same chemotherapy plus trastuzumab. secondary * to conduct exploratory analyses to assess, to the extent possible, if co-localization of stem cellness, as determined by aldh1 positivity, and her2 identifies a group of patients previously considered to have her2-negative cancers (using classical definitions) who benefit from adjuvant trastuzumab. outline: archived breast cancer stem cells samples and terminally differentiated cells from tissue samples are analyzed for her2 and aldh1 expression by dual-staining quantitative immunofluorescence using automated quantitative analysis (aqua) , ihc, and fluorescence in situ hybridization (fish).

Eligibility criteria:
disease characteristics: * tissue samples from patients with node-positive breast cancer whose tumors overexpress her2 * primary tumor samples that are negative for her2 using classically accepted cutoffs determined in the metastatic setting * treated with adjuvant therapy comprising doxorubicin hydrochloride, cyclophosphamide, and paclitaxel with or without trastuzumab in the nsabp-b-31 trial patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: her2-positive breast cancer stage ii breast cancer stage iiia breast cancer
patient perspective of telemedicine in gynecology oncology

Conditions: Oncology

Summary: research question: do patients in a gynecologic oncology practice value the use of telemedicine as an adjunct to in-person visits and in what circumstances might patients not find these visits to be sufficient?

in the united states, 14.8 million women live greater than 50 miles away from the closest gynecology oncologist underscoring the need for increased implementation of telemedicine. in consideration of the covid-19 outbreak, recommendations were made to organize goals of therapy by prioritizing curative intent and utilizing telemedicine to manage current therapies. research regarding telemedicine, its benefits, and patient perspectives in other specialties has been reported, however there appears to be a dearth of information in the field of gynecologic oncology. our study aims to seek patients' perspective of telemedicine and whether implementation for extended office visits, teleconsultations and more are feasible and valuable to them.

Eligibility criteria:
o eligible patients would be at least 18 years of age, and currently being treated by one of the providers within the gynecologic oncology group.

Keywords: telemedicine
efficacy & safety of nasal influenza immunisation in children

Conditions: Influenza Vaccines Efficacy and Safety

Summary: the uk departments of health now recommend annual influenza vaccination for all children 2-7 years of age, with children over 7 years eligible for vaccination if in certain higher risk clinical categories. though data are available documenting the safety and immunogenicity of laiv in this age group, there are little data to assess efficacy and immune correlates in uk children, and in particular atopic children. this study will enrol 200 children (and at least 200 unvaccinated household sibling controls), many with a history of asthma or recurrent wheezing, and allow an assessment of efficacy, safety and immune correlates in these children, and how this varies with prior administration of pandemic influenza vaccine and/or laiv.


Eligibility criteria:
inclusion criteria: * aged 2 - 18 years old * written informed consent from parent/guardian (or patient themselves from age 16 years), with assent from children aged 8 years and above wherever possible. exclusion criteria: * hypersensitivity to the active ingredients, gelatin or gentamicin (a possible trace residue) \[notwithstanding allergy to egg protein\] * previous systemic allergic reaction to laiv * previous allergic reaction to an influenza vaccine (not laiv) is a relative contra-indication, which must be discussed with the site pi to confirm patient suitability * children/adolescents who are clinically immunodeficient due to conditions or immunosuppressive therapy such as: acute and chronic leukaemias; lymphoma; symptomatic hiv infection; cellular immune deficiencies; and high-dose corticosteroids\*\*. \*\*high-dose steroids is defined as a treatment course for at least one month, equivalent to a dose of prednisolone at 20mg or more per day (any age); or for children under 20kg, a dose of 1mg/kg/day or more. * children and adolescents younger than 18 years of age receiving salicylate therapy because of the association of reye's syndrome with salicylates and wild-type influenza infection. * pregnancy * febrile ≥ 38.0 'c in last 72 hours * acute wheeze in last 72 hours requiring treatment beyond that normally prescribed for regular use by the child's treating healthcare professional * recent admission to hospital in last 2 weeks for acute asthma * current oral steroid for asthma exacerbation or course completed within last 2 weeks * received any blood or blood products within the past 12 weeks * any other significant condition or circumstance which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
femoral neck-shaft angle in sohag population

Conditions: Hip Abnormalities; Femur; Angulation; Urinary Stone; Lower Limb Arterial Embolus

Summary: the femur or thigh bone is the strongest and longest bone of the body and about 45 cm long in an average man that means approximately one fourth of the height of individual. it has upper end, lower end and a cylindrical shaft. upper end consists of head, neck. the neck is about 5 cm long, connects the head to the shaft and is directed upward, medially and slightly forward and making an angle about 125 with shaft but the angle is wider in children. the neck-shaft angle (nsa ) is defined as the angle formed by the neck axis and long axis of the shaft of femur.the knowledge of the neck shaft angle is valuable in the diagnosis and treatment of fracture of upper end of femur. the aim of the study is : 1. to evaluate the normal values of femoral neck-shaft angle 2. to detect factors that may affect this angle as age, and sex, in egyptian adults from sohag.


Eligibility criteria:
inclusion criteria: * adults, eligible and adequate imaging data for measurement, and absence of fracture, arthritis, tumor, deformity, or surgery on the proximal part of the femur or any disorder that may affect measurements of femoral neck-shaft angle exclusion criteria: * adults with incomplete imaging data; and fracture, arthritis, tumor, deformity, or surgery on the proximal part of the femur
trip hf study: triple resynchronization in paced heeart failure patients

Conditions: Heart Failure; Ventricular Dyssynchrony

Summary: the purpose of this study is to evaluate the feasibility of permanent biventricular pacing using three ventricular leads, and its efficacy in terms of inter and intra-ventricular resynchronization, in patients with congestive heart failure and a non-functional atrium (chronic af).


Eligibility criteria:
inclusion criteria: • nyha class iii-iv congestive heart failure, in spite of optimal medical treatment for their congestive heart failure for 1 month. the medical treatment must include a 40 mg/day minimum dose of furosemide (or equivalent); * permanent atrial fibrillation (af); * left ventricular ejection fraction (lvef) ≤ 35%; * indication for a pacemaker implantation for a permanent and symptomatic bradycardia, or already implanted pacemaker under the condition that leads positioning corresponds to the criteria described in the protocol; * aortic pre-ejection delay at least equal to 140 ms. exclusion criteria: * indication for a cardiac defibrillator; * having presented a myocardial infarct within the previous 3 months; * having undergone cardiac surgery or coronary revascularization procedure within the previous 3 months, or being scheduled for such procedures; * presenting chronic pulmonary insufficiency; * patients whose congestive heart failure requires the use of an intravenous inotropic support; * presenting a dysthyreosis; * having a life expectancy of less than one year, for other reasons than the congestive heart failure; * unable to be followed-up in the scope of the study for geographical reasons; * having refused to give their consent; * minors (age \< 18 years) and pregnant women.
natural history of coronary heart disease

Conditions: Cardiovascular Diseases; Coronary Disease; Myocardial Infarction; Heart Diseases; Death, Sudden, Cardiac; Heart Failure, Congestive; Heart Failure

Summary: to examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the beta-blocker heart attack trial (bhat) and the aspirin myocardial infarction study (amis).

background: in january 1990, the national heart, lung, and blood institute issued a program announcement establishing a small grants program to provide limited support to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies. this study used data collected in two completed clinical trials, the bhat and amis. design narrative: study endpoints included all-cause mortality, cause-specific mortality such as sudden death, recurrent and non-fatal myocardial infarction, and incident congestive heart failure. univariate and multivariate analyses of baseline data variables from bhat were conducted to determine which were predictive of study endpoints. baseline variables included sociodemograhic characteristics, medical history, medication use, physical examination finds, and electrocardiographic characteristics. baseline characteristics found to be predictive of study endpoints in the bhat placebo group were examined in the amis placebo group. long- and short-term prognoses for patients suffering a transmural myocardial infarction were compared for those suffering a subendocardial infarction. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria