Kornimate/medical-research-clean huggingface dataset:
the effect of acceptance and commitment therapy-based intervention

Conditions: Mental Disorder; Depression Disorders; Stress; Anxiety; Acceptance and Commitment Therapy; Psychological Well-being

Summary: mental health is essential for students' emotional, cognitive, and social well-being. university life presents significant academic, social, and financial challenges, leading to increased stress, anxiety, and depression. these psychological difficulties negatively impact students' academic performance, relationships, and overall quality of life. despite these challenges, many students avoid seeking professional help. acceptance and commitment therapy (act) is an effective approach that enhances psychological resilience and helps individuals cope with stress, anxiety, and depression. instead of changing negative thoughts, act fosters psychological flexibility, encouraging individuals to develop a healthier relationship with them. research supports act's effectiveness in reducing psychological distress, improving emotional regulation, and enhancing life satisfaction


Eligibility criteria:
inclusion criteria: * ust be currently enrolled as a full-time student at a university. exclusion criteria: * individuals with significant cognitive impairments or those unable to understand the study procedures.
study comparing discontinuation symptoms of dvs sr in subjects with major depressive disorder (mdd)

Conditions: Major Depressive Disorder

Summary: study comparing discontinuation symptoms in subjects with major depressive disorder treated for 24 weeks with open-label 50 mg desvenlafaxine succinate sustained-release formulation (dvs sr)


Eligibility criteria:
inclusion criteria: * primary diagnosis of major depressive disorder * hamilton psychiatric rating scale for depression-17-item score of greater than or equal to 14 at baseline exclusion criteria: * current psychoactive substance abuse or dependence, manic episode, or a lifetime diagnosis of bipolar or psychotic disorder * potentially violent to others or is at significant risk for suicide * history or current evidence of gastrointestinal disease or history of surgery known to interfere with absorption or excretion * known presence of raised intraocular pressure or history of narrow angle glaucoma
the psychological effect of the covid-19 pandemic

Conditions: Psychological Distress

Summary: at the end of 2019, the novel coronavirus disease (covid-19), which emerged in china, has become a public health emergency of international concern. disease outbreaks both affect the physical and psychological health of individuals. the aim of this study was to investigate the levels of stress, anxiety, depression, and covid-19 fear in health sciences intern students during the covid-19 pandemic.


Eligibility criteria:
inclusion criteria for students: * be over 18 years old * have taken the professional practice/internship lecture * be practicing in the hospital * not have any disease inclusion criteria for control: * over the age of 18 * without any disease * who routinely work during the pandemic exclusion criteria: * body mass index (bmi) \<17 kg/m2 * any chronic illness, psychological disorder, and perception problem * be dental operation or significant damage to the teeth or oral mucosa

Keywords: psychological distress covid-19 saliva cortisol
turkish validity and reliability of oral health impact on daily life questionnaire

Conditions: Oral Health Related Quality of Life

Summary: this study aimed to test turkish validity and reliability of the oral health impact on daily life questionnaire (ohidl) in adult endodontic patients.the questionnaire was translated and adapted into turkish. then, it was applied to two hundred twenty-two participants aged 18 years.

this study aimed to test turkish validity and reliability of the oral health impact on daily life questionnaire (ohidl) in adult endodontic patients. the questionnaire was translated and adapted into turkish. two hundred twenty-two participants aged 18 years and over without systemic disease were included. the reliability was examined by internal consistency and test-retest reliability. the construct and criterion validity were examined by evaluating the correlation of each question with the domains, the correlation of the domains with the global questions, and the correlation of turkish-ohidl with the turkish version of the oral health impact scale (ohip-14-tr). statistical analysis was performed with spss 21.0 (ibm corp, armonk, ny, usa). p \<0.05 was considered statistically significant.

Eligibility criteria:
inclusion criteria: * patients aged 18 years and older who applied to the department of endodontics exclusion criteria: * patients who did not speak turkish, * patients having cognitive impairment, * patients having communication difficulties

Keywords: oral health quality of life
quantitative assessment of shoulder proprioception in patients with chronic mechanical cervical pain

Conditions: Cervical Pain

Summary: the study was aimed to compare shoulder proprioception in chronic mechanical cervical pain to a matched normal group. this study include 2 groups, 40 subjects with mechanical chronic cervical pain and 40 healthy subjects representing the control group. the primary outcome measure was the shoulder proprioception test of both upper limbs during active repositioning and quantified with angular displacement error.

the study was aimed to compare shoulder proprioception in chronic mechanical cervical pain to a matched normal group. this study include two groups, 40 subjects with mechanical chronic cervical pain and 40 healthy subjects representing the control group. the primary outcome measure was the shoulder proprioception test of both upper limbs during active repositioning and quantified with angular displacement error. test was applied using an isokinetic dynamometer device at angle 30° for both shoulder internal and external rotation on both sides with an angular velocity 30°/sec.

Eligibility criteria:
inclusion criteria: * the age ranged from 20 to 35 years. * body mass index (bmi) between 18 and less than 30. * sufficient cognitive abilities that enables them to understand and follow instructions with a score more than 24 in the mini-mental state examination (mmse) scale. * for the group with cervical pain, participants had a chronic mechanical cervical pain started from three to 12 months. * participants with chronic pain with a score of 3 to 65 according to the short-form of the mcgill pain questionnaire (sf-mpq). exclusion criteria: * shoulder problems. * previous cervical or shoulder surgery. * shoulder or cervical trauma. * cervical radiculopathy. * sever visual and/or auditory problems. * cognitive impairment (a score less than 24 according to mmse).

Keywords: chronic mechanical cervical pain, shoulder proprioception,
effect of remimazolam and sevoflurane anesthesia on recovery in pediatric patients

Conditions: Ophthalmic Abnormalities; Pediatric Disorder

Summary: the most commonly used anesthetic for general anesthesia in pediatric patients is sevoflurane, an inhalation anesthetic. however, the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients is high, with reports of up to 67%. remimazolam (byfavo inj., hana pharm col, ltd., seoul, korea) has a short context-sensitive half-life of 7.5 minutes, and the time it takes from the end of anesthesia until the patient wakes up is predictable. according to a study by yang x et al., administering a small amount of remimazolam (0.2 mg/kg) intravenously at the end of general anesthesia using sevoflurane reduced the incidence of emergence agitation. however, very few studies have evaluated the use of remimazolam in general anesthesia in pediatric patients.

* the most commonly used anesthetic for general anesthesia in pediatric patients is sevoflurane, an inhalation anesthetic. it has the advantage of being able to induce anesthesia without securing an intravenous route and causing less irritation to the airway. however, the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients is high, with reports of up to 67%. emergence agitation can cause physical damage to the patient, workload in the recovery room, and dissatisfaction of the caregiver. * remimazolam (byfavo inj., hana pharm col, ltd., seoul, korea) is a benzodiazepine drug used for inducing and maintaining general anesthesia and for sedation during procedures. when remimazolam is used as a general anesthetic, it has the advantage of being metabolized quickly by enzymes in the liver compared to propofol, has a short context-sensitive half-life of 7.5 minutes, and can be reversed with flumazenil. therefore, during general anesthesia using remimazolam, the time it takes from the end of anesthesia until the patient wakes up is predictable. according to a study by yang x et al., administering a small amount of remimazolam (0.2 mg/kg) intravenously at the end of general anesthesia using sevoflurane reduced the incidence of emergence agitation. * however, very few studies have evaluated the use of remimazolam in general anesthesia in pediatric patients and its effect on endotracheal extubation time after anesthesia in operating room, emergence agitation, pain, and discharge time in the postanesthesia care unit (pacu).

Eligibility criteria:
inclusion criteria: * patients aged between 3 and 18 years old who underwent ophthalmic surgery under general anesthesia * when anesthesia was induced and maintained with remimazolam, or anesthesia was induced with propofol and maintained with sevoflurane. exclusion criteria: - none
tranexamic acid use in elective cesarean section for women with placenta previa

Conditions: Placenta Previa

Summary: tranexamic acid use in elective cesarean section for women with placenta previa

tranexamic acid use in elective cesarean section for women with placenta previa to detect efficacy of tranexamic acid in decreasing blood loss

Eligibility criteria:
inclusion criteria: * term pregnancy (more than 37 weeks of gestation) * diagnosis of placenta previa was confirmed by ultrasound * the patient hemoglobin percentage is more than 10 mg/dl exclusion criteria: * invading placenta previa diagnosis was confirmed by doppler ultrasound studies * emergency lower segment cesarean section * associated medical comorbidities

Keywords: cesarean section placenta previa tranexamic acid
chidamide with chop regimen for de novo ptcl patients (chop: cyclophosphamide, etoposide, vincristine and prednisone; ptcl: peripheral t cell lymphoma)

Conditions: Peripheral T Cell Lymphoma

Summary: this study evaluates the efficacy and safety of chidamide plus chop regimen for de novo ptcl patients.

after enrollment, patients in this study will be given chidamide, cyclophosphamide, epirubicin, vincristine and prednisone, and the efficacy and safety of this regimen are then evaluated.

Eligibility criteria:
inclusion criteria: 1. pathologically diagnosed as peripheral t cell lymphoma (ptcl) according to who 2008 classification criteria（nk/t cell lymphoma, alk positive anaplastic large cell lymphoma and granuloma fungoides excluded）; 2. de novo peripheral t cell lymphoma patients; 3. age 18-70 years old; 4. ecog≤2； 5. female patients not in lactation nor pregnancy, and no intention to concept during the study and 12 months thereafter. male patients agree not to impregnate his partner during the study and 12 months thereafter; 6. the patient should have evaluable foci (lymphnodes with diameter≥1.0cm, or evaluable skin foci); 7. willing to sign a written consent. exclusion criteria: 1. t lymphoblast lymphoma; 2. bone marrow infiltrated with lymphoma cell ≥25%； 3. nt/t cell lymphoma; 4. granuloma fungoides; 5. severe impaired liver/ renal function (alt, bilirubin or creatinine \>3 times the normal maximum); 6. uncontrolled infection; 7. organic cardiopathy with clinical manifestation or impaired cardiac function (nyha ≥ level 2); 8. with other tumors; 9. with other condition that cause the patient unable to sign the written consent;

Keywords: chidamide, chop regimen
antioxidants and pulmonary rehabilitation in copd patients

Conditions: Chronic Obstructive Pulmonary Disease; COPD

Summary: on the basis of published data and investigators results indicating that systemic redox in balance may contribute to the peripheral muscle dysfunction in copd patients, the investigators propose a study testing the effects of antioxidants and exercise training in copd patients. the results may have major implication in the improvement of pulmonary rehabilitation benefits

copd will constitute the third cause of mortality in 2012. this chronic respiratory disease is characterized by peripheral dysfunction of skeletal muscle which is associated with major clinical outcomes (prognostics, symptoms, and health related quality of life). muscle and systemic oxidative stress has been incriminated in this peripheral muscle dysfunction.exercise training constitute the main validated therapeutic intervention leading to significant muscle function and clinical improvement.our preliminary results have shown that copd patients experiment dietary and enzymatic antioxidants defects.yet, generic antioxidant supplementation has not shown significant muscle function improvement.therefore, we aim to test the effects of an antioxidant supplementation targeted on the antioxidant defects associated with exercise training on the peripheral muscle function, exercise tolerance and health quality of life in copd patients.at the cellular level, this muscle dysfunction is related with a fiber atrophy and a metabolic switch (reduce proportion of oxidative fiber).this study will compare the effects of an antioxidant supplementation on the peripheral muscle function and skeletal muscle cellular properties in association with exercise training during a pulmonary rehabilitation course.volunteers will be randomised in 2 groups: - 1 group treated with the antioxidant supplementation ( 28 days)- 1 group treated with the placebointervention will be allocated by chance and a double blind manner. antioxidant supplementation will associate vitamins and trace elements that won't exceed the maximal nutritional dose recommended.

Eligibility criteria:
inclusion criteria: * copd patients, 40 years to 78 years, last exacerbation dating at least 4 weeks exclusion criteria: * unstabilized primary pathologies (cardiovascular, renal, metabolic, psychiatric) * nutritional supplementation in the 4 weeks preceding the study (antioxidant, vitamins...)

Keywords: copd exercise training pulmonary rehabilitation antioxidant muscle
a comparison of cotton and flocked swabs for vaginal self collection

Conditions: Human Papillomavirus Infection

Summary: the purpose of this study is to compare the performance of cotton and flocked swabs for vaginal self-sampling.

vaginal self-sampling for human papillomavirus (hpv) testing has been proposed as an efficient method cover hard-to reach populations in developing countries. while the recent cheap cotton swabs have traditionally been used for deoxyribonucleic acid (dna) detection, recent studies have questioned their efficacy by reporting the superiority of the more expensive flocked swabs. the objective of this study is to compare the performance of cotton vs flocked swabs for cellular retrieval and hpv dna quantification after vaginal self-sampling. a total of 120 women will be recruited. inclusion criteria will be as follows: 21 years of age or older, attending the colposcopy clinic, understanding the study procedures and able to comply with the study protocol. pregnant women, those having previously had a total hysterectomy, and women with ongoing menstruation will be excluded. each woman will collect two different vaginal self samples: one with the cotton swab and one with the flocked swab. subsequently, a flow cytometric analysis, as well as a real time pcr analysis and a cytologic evaluation for specimen adequacy will be run on each sample. agreement between the two methods will be calculated using the kappa statistic (κ).

Eligibility criteria:
inclusion criteria: * attending the colposcopy clinic * accepts voluntarily to take part to the study and signs the informed consent form exclusion criteria: * pregnancy * previous hysterectomy * ongoing menstruations
detection of sepsis occurrence by using blood fluorescence

Conditions: Sepsis; Organ Damage

Summary: this study adopted a case-control study method to explore a reagent-free, highly sensitive, and frequently screened blood fluorescence metabolite analyzer for sepsis, which can detect the emergence of inflammatory free radicals before organ damage and shorten the diagnosis time of sepsis.

currently, clinical practice lacks an effective screening method for early detection and prediction of sepsis. this gap hinders timely differential diagnosis, leading to severe shock and increased mortality rates. although the qsofa score is highly specific, it is not devoid of false negatives. typically, by the time sepsis is confirmed using the qsofa (≥ 2) and sofa (≥ 2) scores as gold standards, the patient may already be suffering from organ damage, thus escalating the risk of death. early-stage septic patients exhibit a surge in inflammatory free radicals, altering the optical characteristics of their blood compared to that of healthy individuals. based on this, we hypothesize that a blood fluorometer could detect these early changes in septic patients, enabling rapid and accurate diagnosis to mitigate mortality rates. this study will conduct a case-control investigation, collecting blood from both admitted and discharged patients, with the aim of developing a reagent-free, highly sensitive blood fluorescence metabolite analyzer. this device will be capable of frequent sepsis screenings, detecting inflammatory free radicals before organ damage occurs, thereby reducing the time to sepsis diagnosis.

Eligibility criteria:
inclusion criteria: 1. healthy control group: individuals who are physically healthy with no underlying diseases and have not been hospitalized within the past two years. recruitment for healthy volunteers will be conducted through notices and online media. 2. sepsis experimental group: patients with confirmed infections, having qsofa ≥ 2 and sofa ≥ 2, will be screened and confirmed by a physician to meet the inclusion criteria. 3. non-septic severe control group: patients with suspected or confirmed infections, having a sofa score of 1, will be screened and confirmed by a physician to meet the inclusion criteria. exclusion criteria: minors, pregnant, individuals with mental illnesses, and other vulnerable groups.

Keywords: sepsis organ damage blood metabolite fluorescence machine learning deep learning fluorescence spectrum analytical platform
loop isolation-based uploading pre-conditioning

Conditions: Ischaemic Heart Diseases

Summary: myocardial protection is of crucial importance for surgical coronary revascularization in patients with ischaemic heart diseases. the investigators proposed loop isolation-based uploading preconditioning to protect heart from ischemic-reperfusion damage (liuphd) as a novel cardioprotective strategy, and applied to patients who underwent on-pump coronary artery bypass grafting (cabg).

myocardial protection is of crucial importance for surgical coronary revascularization in patients with ischaemic heart diseases. considerable effort has been made to optimize cardioprotective strategy for improving cardiac performances after global myocardial ischemia. of various strategies, terminal warm blood cardioplegia (twbc) delivery has been proven to be effective in reducing risk of ischemic attack at the time of myocardial reperfusion. based on twbc strategy and frank-starling law of heart, the investigators proposed loop isolation-based uploading preconditioning to protect heart from ischemic-reperfusion damage (liuphd) as a novel myocardial protective strategy, which procedurally renders coronary loop via brief warm blood delivery independent of extracorporeal loop following twbc delivery just before declamping. the investigators hypothesize that liuphd strategy allows myocardial cells complete depolarization and drives heart into zero-loading heat cycles, contributing to enhancing myocardial physiologic reserve and improving cardiac initiative capacity responding to upcoming loading increases after onset of clamp release. the aim of the present study was to determine whether liuphd strategy during on-pump coronary artery bypass grafting (cabg) can attenuate reperfusion injury after global myocardial ischemia.

Eligibility criteria:
inclusion criteria: * patients scheduled for a first, elective, isolated, open thoracotomy, on-pump cabg were eligible for enrollment if they if they had coronary angiography-confirmed unprotected left main disease, 3-vessel disease with or without proximal lad artery disease, or 2-vessel disease with proximal lad artery disease. * inclusion criteria were evidence of preserved left ventricular function (lvef≥35%) and normal or mild pulmonary hypertension (spap\<50mmhg). exclusion criteria: * exclusion criteria were secondary cabg, emergency cabg, conversion operations form off-pump cabg or minimally invasive cabg surgery, or any additional cardiac lesions necessitating concomitant surgery, as well as being considered too high risk for surgical revascularization.
traditional chinese medicine (tcm) colon dialysis treats non-dialysis end-stage kidney disease

Conditions: Chronic Kidney Failure; End-Stage Kidney Disease

Summary: this study evaluates the clinical efficacy and study the therapeutic mechanism of a kind of traditional chinese medicine colonic dialysis on chronic kidney disease (ckd) 5 without blood dialysis therapy in adults. half of participants will receive conventional integrated therapy on chronic renal failure (crf), while the other half will receive integrated therapy on crf and traditional chinese medicine colonic dialysis.

patients who would hospitalized in nephrology of guangdong provincial hospital of traditional chinese medicine have chance to participate this study. all participates will be divided into two groups depending on their individual treatment interests and the baseline information will be balanced. integrated therapy is routine symptomatic and supportive treatment for crf,including reducing blood pressure and urine protein, improving anemia，regulating calcium and phosphorus metabolism and so on.the colon lotion used in colonic dialysis is a kind of hospital preparation. it consists of rhubarb, concha ostreae and some other traditional chinese medicine.the whole treatment lasts about 10 days,as long as a regular drill-and-fill procedure. before and after the treatment, related body dimensions will be tested.

Eligibility criteria:
inclusion criteria: * 1.corresponding to diagnosis standards of ckd-5:egfr≤15ml/min/1.73m2; 2. did not receive kidney replacement therapy; 3. no gastrointestinal diseases (including ulcerative colitis, irritable bowel syndrome, inflammation, cancer, infection, bleeding, etc.) in the past 1 year; 4.not associated with rectal-related disorders (hemorrhoids, anal fistula, rectal cancer, cancer, infection, bleeding, etc.); 5.sign informed consent. exclusion criteria: * 1. having used antibiotics, hormones, immunosuppressive, probiotics and laxatives in past three months; 2. pregnant or lactating patients; 3.cannot cooperate or tolerate colonic dialysis treatment; 4.combined with active stage of malignant tumors, cardiovascular, respiratory system, decompensated liver cirrhosis or blood system diseases (including coagulation disorders, hematopoietic dysfunction, etc.) and other serious primary disease; 5. recent merger of patients with infectious diseases; 6.having known to be allergic to some drugs in the study.

Keywords: non dialysis