Kornimate/medical-research-clean huggingface dataset:
the effects of music in endoscopic retrograde cholangiopancreatography procedure

Conditions: Endoscopic Retrograde Cholangio-Pancreatography; Anxiety; Pain

Summary: this study aims to investigate the effect of music listening on patients who will have endoscopic retrograde cholangio-pancreatography procedure on vital signs, anxiety, and pain. this will be a randomized controlled experimental study. the study will be conducted with two groups: the intervention group (n=35) and the control group (n=35). the control group will receive standard care while the intervention group, in addition to standard care, will be listened to music by the researchers for 15 minutes before the procedure.


Eligibility criteria:
inclusion criteria: * patients aged 18 or above, * with a scheduled ercp procedure * with the asa grade level of i-ii clinically * without a hearing/speech impairment * willing to participate in the research * without a mental problem or diagnosis of psychiatric disorder * without any a diagnosis of depression exclusion criteria: * patients with an emergency ercp procedure * with a hearing/speech impairment * not willing to participate in the research * with a mental problem or diagnosis of psychiatric disorder * with a diagnosis of depression
the influence of sperm morphology and functional indices on blastocyst development in assisted reproduction

Conditions: Spermatozoa, Abnormal; in Vitro Fertilization; Blastocyst; Aneuploidy

Summary: samples from male partners of 120 infertile couples undergoing ivf were analyzed. sperm morphology was assessed using the spermblue staining method, while tzi, mai, and sdi were calculated. embryo development was monitored until day 5 or 6. statistical analyses included regression models and correlation coefficients to evaluate the predictive value of sperm indices on blastocyst development.

for spermatozoa selection we used zymot multi in all patients undergoing ivf. after intracytoplasmatic injection of spermatozoa we asses the blastocyst grading in day 5. neqsi score meaning numerical embryonic quality score index was used for statistical purpose. the spermatozoa morphology indexes were: tzi (teratozoospermia index), mai (multiple anomalies index), sdi (sperm deformity index) and analyzed with casa analyzer. all these indexes were assessed in patients and correlated in all groups: patients that had a positive pregnancy test, patients that had a negative pregnancy rate, patients that had no blastocyst in day 5 and patients that had all aneuploid embyos.

Eligibility criteria:
inclusion criteria: * couples with an infertility diagnosis that underwent an ivf procedure and had obtained at least one blastocyst exclusion criteria: * donors * uterine abnormalities
pulmonary function test changes and respiratory muscle strength trends in spinal muscular atrophy patients receiving nusinersen treatments

Conditions: Spinal Muscular Atrophy

Summary: it is well known that patients with spinal muscular atrophy (sma) have progressive decline of respiratory muscle function. therapy traditionally involved supportive means to ensure optimal nutrition and airway clearance. nusinersen (spinraza) is a disease-modifying medication approved for treatment of sma in pediatric and adult patients. the goal of this study is to observe pulmonary function test (pft) changes and respiratory muscle strength trends throughout the first year of treatment. a prospective, longitudinal study measuring pulmonary function testing (pfts) changes in spinal muscular atrophy (sma) patients. patients will be patients with sma who are approved and maintained on nusinersen. patient will have a baseline pft. investigators will repeat pft at 3, 6, and 12 months while on nusinersen treatment.


Eligibility criteria:
inclusion criteria: * patients diagnosed with sma of any type who are eligible to start nusinersen treatments at nyu winthrop hospital. exclusion criteria: * patients unable to comply with nusinersen treatments according to recommended schedule (first 3 doses every 2 weeks, then the 4th dose is administered 1 month after the 3rd dose, and then maintenance dose administered every 4 months).
clinical presentations and surgical outcome of obstructive müllerian anomalies

Conditions: Mullerian Duct Anomalies

Summary: the present study aims at: a. the main outcome is to compare preoperative and postoperative visual analog scale vas from 0 to 10 of maximum perceived pain in ladies with omas. 1. description of clinical presentation and percentage of omas in relation to other mullerian anomalies 2. description of different subtypes and its percentage. 3. description of the corrective procedures and their short-term outcomes.

obstructive mullerian anomalies (omas) represent a real challenge in diagnosis and treatment, its incidence is not yet recognized. care givers and gynecologist should be aware with its clinical presentation to avoid its delayed diagnosis and misdiagnosis. in addition, delayed diagnoses may result in retrograde menstruation, recurrent cyclic pains, chronic pelvic pains, poor quality of life and threats to future fertility. cases with complete obstructive müllerian anomalies (c-omas) classically present with recurrent cyclic pains at puberty and their diagnosis is usually established easily. however, cases with hemi obstructive anomalies (h-oma) usually present with progressive dysmenorrhea and delayed diagnosis may result in pelvic adhesions, progressive hematosalpinx and endometriosis which directly threats natural future fertility. h-omas may results from obstructing uterine septa or unilateral cervical obstruction in a double uterus. also, it may result from obstructing longitudinal vaginal septa in cases with double uterus, septate uterus or hybrid septate uterus . a hybrid uterine anomaly is relatively a recent term that described the coexistence of septate and bicornuate uterus together. pure septate uterus has a convex or flat fundus, when there is any fundal depression, it is termed hybrid septate uterus. pain with or without amenorrhoea is the main presentation of omas. surgical correction should improve these symptoms. to the best of our knowledge there is no published prospective trials compared visual analog scale vas in ladies with omas before and after surgical correction.

Eligibility criteria:
inclusion criteria: * all cases with omas or h-omas exclusion criteria: * cases who refuse to participate in the study. 2.cases who underwent previous surgical repair for their oma or h-oma.
circulating tumoral dna in choroidal melanoma (ctdna mu)

Conditions: Choroidal Melanoma

Summary: quantification and follow-up during 3 years of circulating tumoral dna in patients with choroidal melanoma

this study is a prospective, open-labelled, monocentric trial. the aim is to observe, in patient with choroidal melanoma (any stage of the disease), the prevalence of the circulating tumor dna at the diagnostic and its evolution during 3 years. the patient will have a blood sample at the following times : * t0: before treatment of the primary tumor. * t1: 1 months after the end of the local treatment. * t2: at 7 months. * tn: every 6 months up to 3 years.

Eligibility criteria:
inclusion criteria: * aged 18 years old or more. * patient with a recent choroidal melanoma before the start of the specific treatment. * patient able to stand a blood collection. * work-up for extension (ct). * patient explanation given and consent information signed or by legal representative exclusion criteria: * patient without social protection / insurance. * person deprived of liberty or under guardianship. * inability to submit to medical monitoring of the trial for reasons of geography, social or psychological

Keywords: circulation tumor dna choroidal melanoma
effects of manual lumbar and prone traction in patients with low back pain

Conditions: Non-specific Low Back Pain

Summary: the study determined the effects of manual lumbar traction and prone traction on some clinical variables of patients with long standing low back pain.

traction therapy has been used in the management of low back pain (lbp) especially none specific low back pain. there are several recommendations on how lumbar traction should be performed, but the type of technique to be applied differs among the sources. prone traction adapted from inversion therapy which is a form of gravitational traction has been reported to be effective in ameliorating disabilities of patients with low back pain as well reduce pain intensity. manual lumbar traction is performed by the therapist, pulling at the patient's ankles and has been reported to be effective in relieving pain and reducing disability of patient with none specific low back pain (nslbp). documented evidences on the efficacy of traction in non-specific low back pain are still inconclusive. while manual lumbar traction seems more commonly used, probably owing to its positional advantage, its relative effectiveness compared with manual prone traction is still unknown, hence this study. therefore, the aim of this study was to examine the efficacy of manual lumbar traction and prone traction on pain intensity, disability, spinal range of motion and quality of life in patients with none specific low back pain.

Eligibility criteria:
inclusion criteria: * participants diagnosed with non-specific low back pain of not less than 3 months duration who were referred by a physician. * participants between the ages of 40 years and older. exclusion criteria: * low back pain patients with specific pathology, such as systemic inflammatory diseases, pregnancy, fractures of the spine, tumors, infections. * participants with pathology affecting the trunk or upper and lower extremities

Keywords: manual lumbar traction prone traction pain intensity low back pain disability
controlled map in the brain injury patient (comat study)

Conditions: Brain Injuries

Summary: the goal of this randomized controlled trial will be to show that the use of a novel automated system to guide vasopressor administration in brain injury patients will results in more time spent with a mean arterial pressure (map) within the predefined map (+/- 5 mmhg of the target map) compared to patients managed without any automated system (manually management)

in brain injury patients, the maintenance of map within a very narrow range is desired to avoid complications related to hypoperfusion (undertreatment) or hypertension (over treatment). however, the map needed to reach can vary over time based on intracranial pressure. additionally, it is well know that the nurses in the intensive care unit managed multiple patients simultaneously and cannot dedicate 100% of his-her time to adjust drugs infusions. using a novel automated system can overcome this issue and may lead to more time in map target (+/- 5mmhg) than the traditional management. after initial rescuscitation of the patients, patients in both groups will have the same baseline maintenance fluid administration of 1-2 ml/kg/h of crystalloid solution and additionnal fluid boluses administered following the ev1000 monitoring device. the only difference will be the management of vasopressor titration (manual by nurses vs automated via a closed-loop system)

Eligibility criteria:
inclusion criteria: * severe brain injury patients (glasgow score \<9), intubated, ventilated and sedated. exclusion criteria: * glasgow score \> 8 * bilateral mydriasis at the initial management (ambulance and first hour of arrival)
dating of child fractures : chronological repers from the radiological evolution of a series of femur fractures

Conditions: Fractures in Children

Summary: although several studies have studied the predictive nature of non-accidental trauma of the different types of fractures and in particular on the femur, the physiological and radiological particularities of the child make it difficult to estimate the age of a fracture and require defining a chronology specific to the specificities of the pediatric population. some authors have carried out work for the dating of fractures, however the number of cases or the average age of the subjects does not allow a precise estimation of the chronology of evolution of the fractures.


Eligibility criteria:
inclusion criteria: * child aged 18, cared for in the pediatric orthopedic department of the strasbourg university hospitals between january 2007 and december 2020 * fracture of the femur resulting from orthopedic treatment instituted during a period of hospitalization * holders of parental authority who have been informed of the use of their child's data for the purposes of this research and who have not expressed any opposition exclusion criteria: * patient or legal representative who expressed their opposition to participating in the study * fracture of the femur having benefited from a surgical intervention * weakening metabolic or bone pathology * fracture on pathological focal lesion * fractures of the epiphysis or affecting the growth cartilage * impossibility of giving informed information to the subject

Keywords: femur fracture fractures in children pediatric population bony callus
metformin plus paclitaxel for metastatic or recurrent head and neck cancer

Conditions: Head and Neck Neoplasms; Squamous Cell Carcinoma

Summary: metformin plus paclitaxel for recurrent or metastatic head and neck cancer: a randomized phase ii trial

mettax is a phase ii randomized trial that aim to evaluate the addition of metformin to paclitaxel in patients that failed to curative-intent treatment for head-and neck neoplasms. patients eligible for this protocol will be randomized to paclitaxel 175mg/m2 plus metformin or placebo until disease progression or unacceptable toxicity. the primary end-point is disease control (complete response, partial response or stable disease, according to recist 1.1) in the 12th week. secondary end-points are pfs, os, response rate and safety. molecular markers in samples collected before and under treatment will be tested for correlation with clinical outcomes.

Eligibility criteria:
inclusion criteria: * 18 years or older * biopsy-proven head and neck squamous cell carcinoma * ineligibility for curative intent therapy, e.g., surgery or radiation therapy * recurrent or stage iv disease * previous failure to platinum-based chemotherapy * measurable disease according to recist v1.1 * ps ecog 0-2 exclusion criteria: * known hypersensitivity to metformin or paclitaxel * snc metastasis * acute or chronic infection

Keywords: head and neck cancer paclitaxel metformin squamous cell carcinoma
survival validation and gene mutations of n descriptors in the ninth edition of the tnm classification for lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: the international association for the study of lung cancer staging committee recently unveiled the ninth edition of tnm staging system for lung cancer. this study aims to explore survival outcomes, stage grouping, and gene mutations in n descriptors of this new classification system.


Eligibility criteria:
inclusion criteria: pathological n2. exclusion criteria: patients undergoing neoadjuvant chemotherapy
effects of smart vs fire training in chronic ankle instability

Conditions: Chronic Ankle Instability

Summary: the study was a randomized clinical trial with the sample size of 26. the study was conducted at sports club sheikhupura. subjects were enrolled according to eligibility criteria. patients were divided into two groups, each with 13 patients. group a received smart training intervention and warm-up exercises, while group b received foot intensive rehabilitation exercises (fire) and warm up exercises. the session was around 45 to 60 min on each patient with three sessions per week on alternate days. a total of three weeks treatment regime was given to the patients and assessment of patient's strength (cait) and performance (faam) was done at the baseline, after the completion of treatment at three weeks and after six weeks to observe the long-term effects.

ankle sprain is one of the most common sports injuries in physically active individuals and causes a high financial burden on the healthcare system. seventy-four percent of patients with an acute ankle sprain suffered from residual symptoms lasting 29 months after the initial ankle sprain, such as pain, perceived instability, weakness and swelling. lateral ankle sprains (lass) are a common injury sustained by individuals who participate in recreational physical activities and sports. after las, a large proportion of individuals develop long-term symptoms, which contribute to the development of chronic ankle instability (cai).the aim of this study to determine the comparative effects of smart training intervention versus foot intensive rehabilitation (fire) on strength and performance in athletes with chronic ankle instability. the study was a randomized clinical trial with the sample size of 26. the study was conducted at sports club sheikhupura. subjects was enrolled according to eligibility criteria. patients was divided into two groups, each with 13 patients. group a received smart training intervention and warm-up exercises, while group b received foot intensive rehabilitation exercises (fire) and warm up exercises. the session was around 45 to 60 min on each patient with three sessions per week on alternate days. a total of three weeks treatment regime was given to the patients and assessment of patient's strength (cait) and performance (faam) was done at the baseline, after the completion of treatment at three weeks and after six weeks to observe the long-term effects.

Eligibility criteria:
inclusion criteria: * athletes 18-45 years of age, * 2 repeated episodes of giving way, feelings of instability * core training not less than 4 week. * chronic ankle instability more than 6 months. * repeated ankle sprain more than twice and patients with \<24 points based on cait. * athletes with single side ankle instability exclusion criteria: * acute concomitant injuries of the ankle. * individuals who were able to return to pre-injury levels of activity * serious lower-extremity injuries of the last 6 months * lower-extremity surgery, and neurological diseases * simultaneous severe sprain of both ankle joints
effectiveness of kinesiotaping in adolescent idiopathic scoliosis

Conditions: Scoliosis Idiopathic Adolescent

Summary: the effectiveness of kinesiotaping application in addition to exercise in adolescent idiopathic scoliosis will be compared on the pain level with the numerical rating scale, the cobb angle and scoliometer measurements, the quality of life with the scoliosis research association-22 quality of life scale, and the patient's visual perception level with the walter reed visual assessment scale. research group: in addition to the regular exercise program, kinesio taping will be applied to patients diagnosed with adolescent idiopathic scoliosis. kinesio taping will be applied for 5 days on and 2 days off for 4 weeks. control group: patients diagnosed with adolescent idiopathic scoliosis will continue their regular exercise program. no intervention will be applied. patients will be evaluated before and 3 months after treatment in terms of pain level with numerical rating scale, cobb angle measurement and scoliometer measurement, quality of life with scoliosis research association-22 quality of life scale and walter reed visual assessment scale.


Eligibility criteria:
inclusion criteria: * being under follow-up with the diagnosis of adolescent idiopathic scoliosis * having a cobb angle between 10-25 degrees * being willing to participate in the study * having thoracic c scoliosis exclusion criteria: * having a spinal curvature of more than 25 degrees * presence of cardiopulmonary disease and musculoskeletal deformity that will prevent exercise * having an open wound in the area where kinesio taping will be applied or being allergic to the tape application * presence of s scoliosis
predictive ability of therapeutic risk factors in pediatric and adult asthma patients

Conditions: Asthma

Summary: the purpose of this study is to assess the predictive ability of three asthma risk markers: the ratio of controller medication to total asthma medication, an albuterol only marker, and an oral corticosteroid use marker, as well as to compare the precision of these tools between adult and pediatric patient populations. this retrospective longitudinal analysis will use 2 different databases: a large managed care database and a large fee for service medicaid database.


Eligibility criteria:
inclusion criteria: * subjects with asthma as determined by icd-9 codes and asthma drug use * at least 4 years of age * use of at least 1 controller or at least 5 albuterol prescriptions in 12 months exclusion criteria: * subjects with copd or treatment for copd

Keywords: pediatrics medicaid asthma outcomes asthma medication ratio
prebiotics in prevention of atopy

Conditions: Atopic Dermatitis

Summary: the study objective is to evaluate whether a specific prebiotic (gos/pdx) may have an effect in preventing atopic dermatitis, food allergy, intestinal and/or respiratory infections in infants at risk of atopy. in infants with dermatitis, the hypothesis will be tested that prebiotics reduce the severity of the disease.

this study is a prospective, double blind, randomised, 24 month study trial comparing formula with 50/50 mixture of gos/pdx (enfamil premium infant formula 1 for children \<6 months and formula 2 for children ≥ 6 months) versus standard formula (enfamil premium formula 1 and 2). study population is composed by newborns at risk for allergy that will be identified at time of delivery. infants will be eligible if at least one parent or one older sibling have a physician-diagnosed atopic disease (asthma, allergic rhinoconjunctivitis , atopic dermatitis, allergic urticaria, and food allergy as follow described. at time of enrolment (within the first 4 weeks of life) infants will be randomised 1:1 to receive once they will start formula feeding before the day of the 6th month birthday.

Eligibility criteria:
inclusion criteria: 1. gestational age \>37 and \< 42 weeks. 2. birth weight \> 2500 gr. 3. at risk of atopy (see appendix 1). 4. informed consent signed by the parents (see appendix 3). exclusion criteria: 1. congenital immunodeficiency 2. severe congenital disorders or malformations 3. born to mother with diabet 4. long term intake (\> 7 consecutive days) of pro- or prebiotics 5. children who have already assumed ≥ 50 ml for feeding bottle of formulas different from the one object of this study for up to a month. 6. parents expected not to be compliant with the study procedures
attention and achievement: a mind wandering investigation

Conditions: Attention Disturbances

Summary: this study assesses the impact of mind-wandering on reading and math.

this study assesses the impact of mind-wandering on reading and math. specifically 120 middle school student participants will receive descriptive measures (of achievement, attention and related factors including mind-wandering), and will receive a brief (\~30 min) lesson in reading and math (order counterbalanced). participants will receive a brief pre-test, the lesson, and then a post-test on the reading and math outcomes. 75% of the participants will receive a brief manipulation that sets up the influence of mind-wandering, as well as redirects when probe-caught mind-wandering occurs. the remaining participants will receive only redirects, and only randomly. among participants to receive the mind-wandering manipulation, an equal number will receive this only for reading, only for math, and for both reading and math.

Eligibility criteria:
inclusion criteria: * enrollment in schools where we have permission to conduct the study exclusion criteria: * students known to be enrolled in separate curricula (e.g., life-skills classes)