Kornimate/medical-research-clean huggingface dataset:
effects of anesthetic technique on nk cells

Conditions: Pain; Anesthesia; Cancer

Summary: the proposed study is a pilot prospective, single-blinded, randomized controlled trial evaluating the effects of two routine, standard-of-care, anesthetic techniques on natural killer cell population size and cytotoxicity in patients undergoing exploratory abdominal laparotomies.


Eligibility criteria:
inclusion criteria: * 18 - 80 years old of either gender * diagnosis of abdominal tumor scheduled for exploratory laparotomy with study surgeon * must be able to have an epidural exclusion criteria: * asa iv and above * intolerance, allergy, or contraindication to use of either fentanyl or bupivacaine. * significant coronary artery disease (abnormal stress test, myocardial infarction within the last 3 months) * uncontrolled hypertension (bp \> 140/90) * cardiac arrhythmias particularly prolonged qt syndrome * drugs known to cause prolonged qt: class ia antiarrhythmics (quinidine, procainamide, dysopyramide), class iii antiarrhythmics (sotalol, dofetalide, ibutalide, amiodarone), haloperidol, thioridazine, arsenic trioxide, hiv protease inhibitors, tricyclic antidepressants * individuals with significant psychological disorders including: schizophrenia, mania, bipolar disorder or psychosis * pregnant or lactating women * morbid obesity (bmi \> 40 kg/m2) and/or weight \> 150 kg * chronic renal failure ( creatinine \> 2.0 mg/dl) * liver failure e.g., active cirrhosis * alcohol or substance abuse within in the past 3 months * uncorrected hypokalemia, hypomagnesemia, hypocalcemia (can be due to diuretics, mineralocorticoid use, laxatives) * neuropathic pain * chronic opioid consumption (\>30mg oxycodone or greater per day) * cachexia from any cause * systemic use of corticosteroids for greater than 2 weeks in the 6 months prior to surgery * hiv or other immunosuppressive condition * preoperative inr \> 1.4 or platelet count \< 100 * sepsis or overlying skin cellulitis at epidural catheter insertion site * inability to tolerate/unwillingness to have an epidural catheter for intraoperative/postoperative pain control for any reason, including prior back surgery resulting in distorted anatomy that precludes neuraxial anesthesia. * inability to tolerate an epidural solution of either fentanyl or bupivacaine or needs another form of specialized pain control.

Keywords: analgesia cancer natural killer cell opioid
efficacy and safety of shj002 ophthalmic solution in the treatment of corneal erosion in sjogren's patients

Conditions: Corneal Erosion

Summary: the purpose of this study is to measure efficacy and safety with 0.25% shj002 sterile ophthalmic solution compared to vehicle in treating corneal erosion in sjogren's patients. shj002 is an antisense oligonucleotide to neutralize a specific microrna.

participants will be randomized to treatment with shj002 ophthalmic solution or vehicle which will be administered to each eye twice daily for 12 weeks.

Eligibility criteria:
inclusion criteria: 1. male or female participants 18 years of age or older inclusive, at the time of signing the informed consent. 2. diagnosis with sjogren's syndrome and have corneal erosion 3. female participants must be 1 year postmenopausal, surgically sterilized, or females of childbearing potential with a negative urine pregnancy test exclusion criteria: 1. ocular surface corneal disease, other than corneal erosion and dry eye disease (ded). 2. lid margin disorder other than meibomian gland dysfunction (mgd) 3. presence of any ocular condition 4. any history of eyelid surgery or intraocular/ocular surgery 5. cauterization of the punctum or punctal plug 6. use of lid scrubs containing chemicals or baby shampoo, or eyelid makeup 7. use of any of the contraindicated drugs medications 8. any changes in the dosing of any chronically used systemic drug 9. disease, condition, or disorder that in the judgement of investigator could confound study assessments or limit compliance to study protocol 10. known history of alcohol and/or drug abuse within 12 months 11. known allergy or contraindication to any component of investigational product (ip) formulation or diagnostic agents. 12. participation in any drug or device clinical investigation within 30 days

Keywords: corneal erosion
a registry of patients with moderate to severe plaque psoriasis

Conditions: Psoriasis

Summary: the main purpose of the current study will be to provide real - world evidence regarding the safety and effectiveness of secukinumab in the management of patients with moderate to severe chronic plaque psoriasis.

pure is a multi-national, prospective, observational cohort study of patients with moderate to severe chronic plaque psoriasis aimed at assessing the real-world safety and effectiveness of secukinumab and other indicated therapies. the study will enroll patients for whom, prior to and independent of study enrollment, the treating physician has decided to treat with secukinumab, or one of the other indicated therapies regimens approved for the management of moderate to severe chronic plaque psoriasis. two study cohorts will be defined by patients treated with secukinumab (cohort 1), and patients treated with other indicated therapies (systemic, phototherapy, or biologic therapy; cohort 2). each investigator will recruit approximately the same number of patients in each treatment arm. 2,500 patients (1,250 patients in each cohort) will be followed over a period of 5 years from the baseline assessment (visit 1).

Eligibility criteria:
inclusion criteria: 1. - patients able to give written informed consent 2. - patients at least 18 years of age at time of informed consent signature 3. - confirmed diagnosis of chronic moderate to severe chronic plaque-type psoriasis diagnosed by a specialist and presence of moderate to severe psoriasis symptoms according to physician's clinical judgment at the time of recruitment. 4. - patients initiating a treatment for psoriasis as per regional policy. this will include secukinumab, other biologics, systemic treatments, and phototherapy. decision to treat with any of the above-mentioned treatments must have been reached prior to and independently of recruitment in the study. 5. - treatments prescribed in accordance to the product monograph and regional regulatory and reimbursement policies 6. - patients able to understand and communicate with the investigator and comply with the requirements of the study. exclusion criteria: 1. - unwillingness or inability to comply with the study requirements 2. - participation in a clinical trial of an investigational drug, concurrently or within the last 30 days.

Keywords: psoriasis plaque psoriasis chronic plaque psoriasis cosentyx secukinumab moderate to severe plaque psoriasis pure registry registry
implementing an eating disorder prevention program for youth in nova scotia

Conditions: Body Image; Body Dissatisfaction; Dietary Restraint; Negative Affect

Summary: the goal of this study is to evaluate the body project, which is an eating disorder prevention program for youth 15-22 years old. the main question it aims to answer is 'can an eating disorder prevention program, specifically the body project, be successfully delivered to youth in nova scotia'? this study will determine the feasibility of implementing the body project in nova scotia by assessing the following objectives: 1. acceptability (how well the body project is received by, and the extent to which it is perceived as meeting the needs of, youth in nova scotia). 2. demand (the extent to which youth in nova scotia are interested in and willing to engage with the program). 3. integration (the extent to which the body project is judged as feasible by the group facilitators). 4. effectiveness (the extent to which the body project reduces eating disorder risk factors in youth in nova scotia). participants will: * attend a total of 4 hours of body project group sessions, which are led by peer mentors. * complete outcome measure questionnaires before their first session and after their last session. * participate in a focus group with their session group members after their last session.


Eligibility criteria:
inclusion criteria: * self-identify as a girl/woman. * be between the ages of 15-22 years old. * for inclusion in an in-person group, an individual must be currently enrolled as a student at the school where they will participate in sessions. * for inclusion in a virtual bp group, an individual must live in and/or attend school in nova scotia, and have access to a computer (e.g., laptop, desktop computer, cellphone) with internet connection and a webcam that can be used in a private location (if a participant does not have a private location to use when attending sessions, they will be asked to wear headphones). * able to complete english computer-based self-report questionnaires (with adequate accommodation, if necessary). * provides informed consent (or verbal assent with informed consent provided by parent/guardian). exclusion criteria: * previous participation in the body project.
hainan community cognition cohort

Conditions: Cognitive Impairment; Dementia; Age Problems

Summary: this is a community-based prospective cohort study in hainan province, china. the study was initialized in 2023 and included older residents for longitudinal follow-up. the research aims to identify risk factors as well as health and social outcomes that are associated with cognitive impairment in elderly populations, and independently develop ai-assisted software and applications for cognitive enhancement and physical rehabilitation training.

this is a community-based prospective cohort study in hainan province, china. subjects are individuals aged 60 years and above who have lived in the communities for more than six months and have signed informed consent. the research have been initialed in 2023 and aims to identify the risk factors associated with cognitive impairment, to develop software for cognitive enhancement and physical rehabilitation training. the study includes three steps: first, to conduct cognitive function screening in 16 communities in four districts (xiuying, meilan, longhua, and qiongshan) of haikou city and establish a database for the elderly in tropical regions; second, to identify risk factors associated with cognitive impairment in the elderly population; finally, to independently develop a software for cognitive function enhancement and physical rehabilitation training.

Eligibility criteria:
* inclusion criteria: * age 60 years and above * lived in the community for more than 6 months * signed the informed consent form * exclusion criteria: * cannot complete the survey
is there a correlation between surgical technique for primary anterior cruciate ligament surgery and the risk of subsequent formation of fibrous cyst (cyclops) in the knee joint, which leads to the need for surgical removal of the cyclops?

Conditions: Cyclop Arthrofibrosis Anterior Cruciate Ligament

Summary: fibrous scar tissue formation (cyclops) after a primary anterior cruciate ligament reconstruction (aclr) may affect patients' ability to perform work and exercise to such an extent that further arthroscopic surgery may be necessary. the purpose of the study is to estimate the 2-year incidence of removal of cyclops lesion after aclr for a cohort of approximal 3000 patients operated at aarhus university hospital in the period 2005-2019. specifically, change in surgical technique and graft choice will be analyzed.


Eligibility criteria:
inclusion criteria: * patient \>18 years * primary acl reconstruction exclusion criteria: * multiligament reconstruction * revisions * acl reconstruction with double bundle graft
effects of vitamin c and e on endothelial function in adolescent diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: the endothelium is the lining of the blood vessels that helps prevent damage to the vessels. the endothelium does not function as well as it should in adolescents with type 1 diabetes. this causes future diabetes complications. adolescents with diabetes also have abnormalities of the cells that repair the endothelium. these abnormalities may be due to damage caused by intermittent hyperglycemia. this studied is designed to study whether low dose, combined vitamin c and e supplementation improves endothelial function and repair in adolescents with type 1 diabetes.


Eligibility criteria:
inclusion criteria: 1. children and adolescent with t1d between 8 and 15 years of age will be studied. 2. started on insulin therapy immediately after diagnosis. 3. fasting c-peptide levels must be less than 0.4 ng/ml. 4. hgb a1c levels greater than 8.3%. 5. all subjects must be in good health other than having diabetes. subjects with hypothyroidism will be allowed assuming they are on stable thyroxine replacement and have normal thyroid function tests. 6. females on oral contraceptives will also be eligible to participate. exclusion criteria: 1. history oral hypoglycemic agent use. 2. bmi\>95th percentile 3. hypertension 4. elevated creatinine levels 5. microalbuminuria.

Keywords: type 1 diabetes endothelial function adolescents vitamin c vitamin e
the application of rapid fresh digital pathology on the diagnosis and biomarker testing of lung cancer

Conditions: Lung Cancer; Intraoperative Pathology; 3D Pathology; Immunochemistry Staining

Summary: through this project, the rapid staining process will be optimized for ex-vivo human lung specimens and integrate advanced ex-vivo mesoscale nonlinear optical gigascope. initially, this will provide rapid digital pathological diagnosis during lung cancer surgeries. this will help achieve the dual goals of precise and efficient complete resection of lung cancer tissues while preserving tissue functionality. the application of this technology aims to provide higher-quality medical services for patients suffered from lung cancers.

frozen section can provide rapid diagnosis during the operation, and its information is very important for surgeons to make decisions for the operative methods, especially for patients whose clinical conditions or lesions sites are inappropriate for biopsy. the frozen section procedure requires a pathological laboratory, a skilled technician, and an experienced pathologist. not all pathological laboratories can perform the frozen section procedure. the frozen section can also cause frozen artifacts and tissue loss especially for small biopsy samples. in this study rapid fresh digital pathology combining the rapid whole-mount hematoxylin-eosin (h\&e) tissue staining (the-rts) method and optical imaging via mesoscale nonlinear optical gigascope (mnlog) will be used to obtain digital images with ultra-high resolution of resected lung specimens. these images will be analyzed by experienced pathologists and compared with h\&e-stained slides from traditional frozen section procedures to see if the rapid fresh digital pathology can be used as an alternative method for intraoperative frozen section procedure. moreover, the potential to use rapid fresh digital pathology in the detection of lung cancer biomarkers (including low-grade or high-grade patterns, invasive or in situ lesions, and stas) and three-dimensional pathology will also be evaluated.

Eligibility criteria:
inclusion criteria: * (1) adults aged 20 and above. * (2) patients diagnosed with lung cancer or lung tumors, scheduled for surgical resection. a total of 300 patients are expected to be included. exclusion criteria: * (1) patients unable to provide consent. (e.g., inability to speak, inability to communicate in chinese, etc.). * (2) patients for whom a definitive pathological diagnosis cannot be established. * (3) patients suitable only for biopsy and not for surgical resection. * (4) exclude specimens that are too small or lesions that are too small to retain extra tissue.
surveillance and follow-up for latent tuberculosis infection and observation of the effect of prophylactic latent tuberculosis treatment in patients with severe chronic kidney disease or receiving long-term dialysis

Conditions: To Determine the Prevalence of Latent Tuberculosis in Each Group; To Monitor the Occurrence of Active Tuberculosis

Summary: to follow-up the latent tuberculosis infection and evaluate the risk of developing active tuberculosis in patients with severe chronic kidney disease or receiving long-term dialysis

tuberculosis (tb) remains an important infectious disease worldwide. taiwan is still an edemic area. in 2008, there is an incidence of 62 persons having tb per 100,000 population. to control tb, we should prevent further tb transmission via early diagnosis and treatment of latent tb. in screening the risk population for tb, patients with renal failure acquiring long-term dialysis, in addition to close contacts, have higher incidence and mortality than general population. moreover, the risk for active tb in dialysis patients is ten to 25 times larger. in taiwan, the dialysis group is important because it has higher prevalence (2228 per in per million people by 2009 annual report of united states renal data system) than other countries in the world. in particular, the dialysis patients usually has an extrapulmonary presentation for their tb, so diagnosis is always delay. hence, we should detect latent tb in those dialysis patients for monitor them from active tuberculosis. currently, interferon-gamma release assays (igras) are used for finding out those with latent tb and have been proven useful for those being immunocompromised, and having bcg vaccination. for dialysis patients, igras have been tested and been considered better than skin tuberculin test. however, previous studied rarely observed the patients receiving peritoneal dialysis and severe chronic kidney disease. besides, those cross-sectional studies used the indirect evidence for diagnosis and lacked longitudinal follow-up. we thus conducted this study for observing the prevalence of latent tb in those receiving hemodialysis or peritoneal dialysis by using igras. we also kept follow-up for the primary outcome of active tb occurrence.

Eligibility criteria:
inclusion criteria: * older than 20 years old * estimated ccr \< 30 ml/min as group of severe chronic kidney disease * long-term (\>3months) dialysis as dialysis group exclusion criteria: * refusal of recruitment

Keywords: latent tuberculosis infection, tuberculosis, chronic kidney disease, peritoneal dialysis, hemodialysis
comparison of traditional superficial cutaneous sutures versus steri-strip coaptive film in layered dermatologic closures

Conditions: Wound Cosmesis

Summary: the purpose of this study is to compare the cosmetic outcome between buried intradermal and superficial cutaneous suture closures versus buried intradermal sutureand superficial steri-strip closures in the bilayered repair of dermatologic wounds on the back following elliptical excision of benign or malignant lesions


Eligibility criteria:
inclusion criteria: * 18 years or greater in age * simple excision of benign or malignant lesion on the back * final scar length of at least 3cm exclusion criteria: * known history of keloid formation or hypertrophic scars * known adhesive allergy * pregnancy or active breast feeding

Keywords: scar appearance
prevalence survey in france of unintentional perioperative hypothermia and its impact on two outcomes

Conditions: Hypothermia, Perioperative

Summary: the primary objectives of the study are * to perform a survey on the clinical management of unintentional hypothermia during surgery in france. * to assess the impact of perioperative hypothermia on anemia and myocardial injury.

100 investigation centers in metropolitan france will participate in the study, targeting 2000 included patients (20 surgical interventions in each center). the duration of inclusion in each center should last at most 2 weeks. the selected surgical interventions will be those performed with a high frequency, practiced in all types of hospitals (public, private, university hospital or not), and requiring anesthesia of at leat 30 minutes (general, epidural or intrathecal anesthesia).

Eligibility criteria:
inclusion criteria: * non-ambulatory surgery. * duration of anesthesia \> 30 minutes. * type of surgery: urology, gynecological, gastrointestinal, vascular and orthopedics surgery. * type of anesthesia: general, intrathecal or epidural anesthesia. * patient ≥ 45 years. * no opposition of patient to participate in the study. exclusion criteria: * emergency surgery. * cardiac surgery, proctology surgery or thoracic surgery. * digestive endoscopy or surgical radiology. * septic surgery. * patient with at least one organ failure.

Keywords: hypothermia prevalence perioperative anemia myocardial injury troponin t noncardiac surgery
efficacy of a cognitive behavioral therapy to decrease threat appraisal in hiv participants initiating antiretroviral

Conditions: HIV; Threat Appraisal

Summary: studies in the field of health and hiv indicate that threat appraisal is associated with poor adherence to treatment, anxiety, poor quality of life, avoidance behavior, less antiretroviral adherence, negative affect, social, instrumental and emotional stress, depression, global distrés, poor subjective health and psychological distres. most psychological interventions have been oriented to behavioral aspects, leaving aside cognitive aspects such as threat appraisal, so is necessary to investigate psychological treatments and its impact in threat appraisal an in an clinical and psychological outcomes. primary objective: to evaluate the efficacy of a cognitive behavioral therapy (cbt) to decrease threat appraisal in comparison with usual care (uc) in hiv patients initiating antiretroviral treatment at week 8. secondary objectives: to evaluate the effect of a cognitive behavioral therapy intervention compared with usual care in hiv patients initiating antiretroviral treatment in the following variables: challenge appraisal, affect (positive and negative), adherence, quality of life, anxiety and depression, hiv viral load and loss to follow-up at weeks 8, 20 and 52. exploratory objectives: to assess the threat appraisal cut-off value that predicts favorable outcomes in adherence, virologic suppression, retention in care and adverse events at week 52. the study is an open label, single center, parallel group clinical trial, in which 50 participants will be randomly assigned using a blocked design to one of the 2 arms: usual care (single individual psycho-educative session) or cognitive behavioral therapy (usual care + 6 sessions of individual cognitive behavioral therapy). the sample will be conformed with 50 adults with hiv, naïve to arv treatment, starting care at incmnsz, who have scores of threat appraisal ≥40 in the ceat scale, without severe mental disorders or cognitive impairment. we will use independent t test and chi square and intention to treat analysis for the primary outcome, also for secondary outcomes t student for continuous variables, chi square for categorical variables and per protocol analysis in participants adherent to the intervention.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * hiv diagnosis confirmed * naïve to antiretroviral treatment * threat appraisal greater than or equal to 40% * enrolled at incmnsz for medical care * be able to read and write * willing and able to provide written informed consent exclusion criteria: * psychotic symptoms * severe depression * severe anxiety * suicide risk * substance dependence * cognitive dysfunction * psychological or psychiatric treatment within previous 3 months * require emergency medical attention

Keywords: hiv threat appraisal cognitive behavioral therapy antiretroviral-naïve challenge appraisal affect adherence quality of life anxiety depression viral load loss to follow-up