Kornimate/medical-research-clean huggingface dataset:
modern analyses of the semen in evaluating male fertility and treatment options of male infertility

Conditions: Infertility, Male

Summary: men are recruited to collect seminal plasma samples and serum samples from men with azoospermia, men receiving medical treatment of infertility and men attending semen analysis. microrna (mirna) and piwi-interacting rna (pirna) are analyzed for all of the groups to find potential differences. steroid hormones are analyzed by liquid chromatography-tandem mass spectrometry.

azoospermic men attending microdissection testicular sperm extraction (md-tese) are group a. second group (b) is the men with poor semen quality, who are treated with aromatase inhibitor, antiestrogen or human choriogonadotropic hormone (hcg) to improve semen quality. third group (c) consists of men submitting semen analysis. the intended number of participants is 60, 60 and 100 men, respectively. seminal plasma and serum samples are collected and mirna and pirna are analyzed. steroid hormones are analyzed by liquid chromatography-tandem mass spectrometry. the participants are given a physical examination and testicular ultrasound. the primary aim of this study is to develop a tool to better estimate the sperm recovery rate (srr) of azoospermic men scheduled for md-tese. since no data have been published presenting mirna and pirna levels in men with normal semen, a secondary aim is to describe the levels of mirna and pirna in unselected men. third part of this study aims to find if medical treatment improving semen parameters affects mirna ja pirna findings.

Eligibility criteria:
inclusion criteria: * ability to produce semen sample exclusion criteria: * cognitive impairment * inadequate language skills for informed consent

Keywords: azoospermia male fertility md-tese mirna pirna male infertility
high-density in spinal cord stimulation: virtual expert registry

Conditions: Failed Back Surgery Syndrome

Summary: this is a prospective, multi-center, observational follow-up study observing the effectiveness of high density spinal cord stimulation in patients with failed back surgery syndrome patients with back and leg pain.

discover will measure the effectiveness of high-density spinal cord stimulation for treatment of chronic back and leg pain. identification of clinical effective parameters concerning location of active electrodes, frequency, pulse duration, amplitude and battery consumption are, besides safety, the major outcome parameters of this study.

Eligibility criteria:
inclusion criteria: * failed back surgery syndrome patients (fbss) with insufficient pain reduction with conventional scs or fbss patients suitable for scs * age \> 18 years * chronic pain as a result of fbss that exists for at least 6 months with a pain intensity 5 or higher measured on numeric rating scale (nrs) * patient has been informed of the study procedures and has given written informed consent * patient willing to comply with study protocol including attending the study visits exclusion criteria: * expected inability of patients to receive or properly operate the spinal cord stimulation system * history of coagulation disorders, lupus erythematosus, diabetic neuropathy, rheumatoid arthritis or morbus bechterew * active malignancy * addiction to any of the following drugs, alcohol (5e/day) and/or medication * evidence of an active disruptive psychiatric disorder or other known condition significant enough to impact perception of pain, compliance to intervention and/or ability to evaluate treatment outcome as determined by investigator * immune deficiency (hiv positive, immunosuppressiva, etc.) * life expectancy \< 1 year * local infection or other skin disorder at site of incision * pregnancy * other implanted active medical device

Keywords: high density spinal cord stimulation virtual expert registry
lomatuell pro® versus urgotul® in the management of acute wounds

Conditions: Acute Wounds

Summary: comparative evaluation of the properties of the contact layer dressing lomatuell pro® versus urgotul® in the management of acute wounds

national, multicenter, prospective, randomized in parallel groups, non-inferiority, open-label investigation study.

Eligibility criteria:
inclusion criteria: * acute wound: traumatic wound (dermabrasion, skin tears, other), small burns 1st and 2nd degree requiring the use of dressings * acute wound size between 3 cm² and 24 cm² (wound could be covered by 2 investigational products maximum) * wound whose duration is ≤ 3 days * both gender with an age ≥ 18 years * written confirmation from the study nurse that the patient was informed, orally agreed to participate and to comply with study treatment and planned visits * subject able to follow the protocol exclusion criteria: * chronic and acute surgical wound * infected, moderately to strongly exudative and haemorrhagic wound * diagnosed underlying disease (e.g. diabetic neuropathy, stroke, etc.) which as judged by the investigator could interfere with the pain assessment * known allergy/hypersensitivity to any of the components of the investigational products * participation in other clinical investigation within one month prior to start of investigation * pregnant or breast-feeding women * person protected by a legal regime (tutorship or guardianship) * patients unable to manifest an oral consent to participate (e.g. dementia) or to understand the use of the vas (visual analogue scale) tool * patient not covered by health insurance/social security
intralesional measles, mumps, rubella (mmr) vaccine versus cryotherapy in treatment of multiple common and planter warts

Conditions: Common Wart; Plantar Wart

Summary: warts are benign epidermal tumors caused by human papilloma virus, which are epitheliotropic non-enveloped double stranded dna viruses. transmission of warts occurs from direct person-to-person contact or indirectly by fomites . warts appear in various forms including verruca vulgaris, plane, plantar, filiform, digitate and periungual.

treatment of warts is difficult for patients and physicians . currently available treatment options include cryosurgery, laser, electrosurgery, bleomycin, and topical keratolytic applications; many of them are painful, ineffective, costly and prone for recurrences. cryotherapy, which uses liquid nitrogen to freeze tissues and destroy warts, is one of the most common and effective treatments. freezing causes local irritation, leading the host to mount an immune reaction against the virus. immunotherapy appears to enhance virus recognition by immune system; allowing clearance of treated wart, distant warts , and helps to prevent infection .recently, intralesional immunotherapy using different antigens such as mumps, candida, and tuberculin has been proved effective in the treatment of warts. the exact mechanism of action of intralesional immunotherapy is still obscure. intralesional antigen injection probably induces strong non specific inflammatory response against the human papilloma virus-infected cells. it has been suggested that intralesional measles mumps rubella vaccine results in regression of warts via induction of immune system.

Eligibility criteria:
inclusion criteria: * patients should have multiple common or plantar warts. * no concurrent systemic or topical treatment of warts exclusion criteria: * patients under 16 years old. • patients with fever or signs of any inflammation or infection. * patients with other types of warts. * patients with single warts. * pregnancy. * lactation. * immunosuppression. * patients who received any other treatments for their warts in the month before starting study. * past history of asthma, allergic skin disorders, meningitis or convulsions.
online personalized intervention for the prevention of anxiety.

Conditions: Anxiety Disorders

Summary: objective: to design, develop and evaluate an online personalized intervention based on a risk algorithm for the universal prevention of anxiety disorders in the general population. methods: randomized controlled trial, with two parallel arms and 12 months follow-up. the entire process of recruitment, randomization, intervention and follow-up will be carried out from a web platform designed for the study (web prevans). through a communication campaign, where announcements and informative videos will be produced, and through the dissemination on prevans website, 2,000 spanish and portuguese adult participants without anxiety in the baseline of the study will be recruited. the participants will be randomly assigned to the prevans intervention, which will be self-guided and can be implemented from the prevans web or from the participants' smartphone (through an app), or to a control group. the prevans intervention will have different intensities depending on the risk level of the population, evaluated from the already validated risk algorithm for anxiety: predicta. participants with a low risk of anxiety will receive information on their level and profile (risk factors) of anxiety and psychoeducational information periodically. participants with moderate and high risk of anxiety will also receive information on their risk level and profile, but will also include a cognitive-behavioral training (problem solving, decision-making, handling thoughts / concerns and emotions and communicational skills). both groups of risk will work towards manage stressors and enhance protective factors. the control group will not receive any intervention, but they will fill out the same questionnaires as in the intervention group. the main result will be the incidence of new cases of anxiety disorders measured by cidi, and the secondary results will be the reduction of anxiety (gad-7) and depression (phq-9) symptoms, of the risk probability of anxiety and depression (predicta and predictd algorithms) and improvement of quality of life measured by sf-12 and euroqol, and cost-effectiveness and cost-utility.


Eligibility criteria:
inclusion criteria: * gad-7 \<10 at baseline * gad-7 ≥10 at baseline and a negative diagnosis of anxiety disorders by cidi exclusion criteria: * not have a smartphone and internet for personal use * unable to speak spanish * documented terminal illness * documented cognitive impairment * documented serious mental illness (psychosis, bipolar, addictions, etc.) * being involved in any psychological intervention or treatment

Keywords: anxiety disorders primary prevention randomized controlled trial m-health e-health
a multi-center study comparing the clinical performance of two silicone hydrogel lenses over 1 month of daily wear

Conditions: Myopia

Summary: a multi-center study comparing the clinical performance of two silicone hydrogel lenses over 1 month of daily wear

two-month, single masked, randomized, bilateral, crossover, 1-month of daily wear in each study lens.

Eligibility criteria:
inclusion criteria: * is between 18 and 40 years of age (inclusive) * have the use of a mobile phone to send and receive text messages throughout the day for the duration of the study * has had a self-reported visual exam in the last two years * is an adapted soft cl wearer * has a contact lens (cl) spherical prescription between - 1.00 and - 9.00 (inclusive) * has less than 0.75d spectacle cylinder in each eye * is correctable to a visual acuity of 20/25 or better in both eyes * has clear corneas and no active ocular disease * has read, understood and signed the information consent letter * is willing to comply with the wear schedule (at least 40 hrs per week) * is willing to comply with the visit schedule exclusion criteria: * has never worn contact lenses before * currently wears rigid gas permeable contact lenses * has a history of not achieving comfortable cl wear (5 days per week; \> 8 hours/day) * has a contact lens prescription outside the range of - 1.00 to -9.00d * has a spectacle cylinder greater than -0.50d of cylinder in either eye * has best corrected spectacle distance vision worse then 20/25 in either eye * has any systemic disease affecting ocular health * is using any systemic or topical medications that will affect ocular health * has any ocular pathology or severe insufficiency of lacrimal secretion * has persistent, clinically significant corneal or conjunctival staining * has active neovascularization or any central corneal scars * is aphakic * is presbyopic * has undergone corneal refractive surgery * is participating in any other type of eye related clinical or research study
obesity index that better predict ovarian response

Conditions: Infertility

Summary: this study is designed to assess the accuracy of body mass index ,waist circumference ,waist hip ratio or waist height ratio as a predictor of ovarian response in women undergoing icsi.

obesity is an increasingly serious health concern worldwide, and its association with many diseases has been demonstrated. obesity as it relates to infertility is also being studied all these studies used body mass index (bmi) to determine obesity. although it is the most commonly used parameter to measure obesity, bmi does not provide an accurate measure of a person's body composition, including body fat. almost all studies conducted on this subject used body mass index (bmi) as the measure of obesity; however, using only bmi might be the wrong strategy. interestingly, some studies on the cardiovascular system found protective effects of bmi and as a result a new term, 'obesity paradox,' emerged. later studies used waist-to-hip (w/h) ratio and wrist circumference (wc) as a measure of obesity, and showed the exact effect of body fat distribution and obesity on the cardiovascular system

Eligibility criteria:
inclusion criteria: * patients scheduled for icsi exclusion criteria: * poor responders. * poly cystic ovary syndrome. * previous ovarian surgeries. * patients with ovarian cysts * patients with endometriosis * women age more than 35 years

Keywords: obesity index, icsi
abnormalities of preoperative ascending urethrocystography and outcomes of living donor kidney transplantation

Conditions: Kidney Transplantation

Summary: to evaluate effects of abnormalities in preoperative ascending urethrocystography on the short-term outcomes of ldkt

the incidence of surgical complications after kidney transplantation (kt) has decreased in recent decades due to improvements in surgical techniques and immunosuppression protocols. however, the preoperative abnormalities of the urinary tract may influence the outcomes of kt. hence, the preoperative evaluation of the urinary tract is a critical step in the kt process to identify the potential risk factors for poor outcomes . ascending urethrocystography (auc) is a key diagnostic tool to assess the integrity and functionality of the lower urinary tract . it provides detailed insights into the bladder, urethra, vesicoureteral valves, and surrounding structures, identifying any abnormalities that could pose risks during or after kt . understanding this issue is crucial, as certain urological anomalies may predispose patients to complications such as urinary leaks, infections, or delayed graft function, potentially leading to poorer short-term outcomes . although auc is used indiscriminately as a screening test for urological abnormalities, only 6% of all kt recipients may have abnormal lower urinary tract . few studies have looked at the yield from auc and attempted to assess objectively whether certain patients could be selected for kt based on a positive result in auc . accordingly, the impact of abnormalities detected in auc on the short-term outcomes of living donor kt (ldkt) remains inefficiently studied . this is the rationale to conduct this cohort study on patients undergoing ldkt. we hypothesize that the presence of abnormalities in auc will influence the surgical outcomes and short-term survival rates after ldkt

Eligibility criteria:
inclusion criteria: * pediatric and adult patients undergoing ldkt in assiut kidney transplantation unit. * patients with preoperative evaluation by auc. exclusion criteria: * patients with a primary non-functioning graft after ldkt. * patients with missing relevant preoperative or postoperative data. * patients refusal to participate in the study.

Keywords: preoperative ascending urethrocystography
freestyle libre- effect on qol in type 2 diabetes patients

Conditions: Type 2 Diabetes

Summary: this is a randomized controlled study in type 2 diabetic patients who are presently uncontrolled on at least 2 injections of insulin daily with an a1c \>7.5 % and \<10%. patients need to be stabilized on their mdi for 1 week then randomized to either sbgm or freestyle libre for 10 weeks.

freestyle libre flash glucose monitoring system is an interstitial glucose monitoring system intended to be replacement for the capillary blood glucose measurement. the system contains several features that distinguish it from exiting sensor technology including no user calibration during 14 days of wear. the sensor is applied to the upper arm of the patient and the hand-held reader is used to scan the sensor to receive glucose result along with historic results with a 15 min frequency for up to 8 hours. an agp (=ambulatory glucose profile) report is a way to present the glucose data collected by the time of day that has several advantages: demonstrates median glucose levels and the 25-75%, 10-90% excursions as well as the tendency for hypo or hyperglycemia throughout the day. this integration of results gives a more complete picture of the glucose control throughout the week/s while eliminating the "noise" from outliers. the hypothesis is that the addition of freestyle libre system for 10 weeks to the treatment of uncontrolled type 2 diabetic patients currently on mdi, will produce a modification of behavior/life style and improvement in treatment satisfaction, quality of life and glycemic control and reduce the number of any/major hypoglycemia events.

Eligibility criteria:
inclusion criteria: 1. type 2 diabetes - more than 1 year 2. age: 30 - 80 yrs 3. treated with mdi: ≥ 2 injections daily 4. hba1c: 7.5% to 10% 5. willing to measure 7 daily blood tests at least one day each week 6. willing to sign informed consent exclusion criteria: 1. type 1 diabetes 2. cv event within the last 6 months 3. steroid therapy \> 7 days in last 6 months 4. retinopathy - grade 3 5. creatinine \>2 mg%

Keywords: insulin treated
covid-19 pandemic and cerebral palsy

Conditions: Cerebral Palsy; Covid19; Telemedicine; Caregiver Quality of Life; Disability, Developmental

Summary: investigator aimed to analyzed the effect of covid-19 pandemic on the physical-psychosocial and cognitive state of the children, to benefit form the health, education services and the caregiver's quality of life with telemedicine.

telemedicine is an application that provides remote healthcare services. telemedicine method has been reported to be useful in chronic conditions such as cerebral palsy (cp). patients with cp need regular follow-up, regular physiotherapy, orthosis use, using of antispasmodic drugs, repeated botulinum toxin applications or intrathecal baclofen to reduce spasticity and increase functionality. during the covid-19 pandemic period, these patients could not come to their controls due to reasons such as difficulty in reaching the doctor, fear of infection transmission, could not continue physiotherapy, repeated botulinum toxin applications could not be performed and necessary operations could not be performed. in this cross sectional study, investigator aimed to analyzed the effect of covid-19 pandemic on the physical-psychosocial and cognitive state of the children, to benefit form the health, education services and the caregiver's quality of life with telemedicine.

Eligibility criteria:
inclusion criteria: * patients' ages between 3-18 years * caregiver of patients diagnosed as cerebral palsy * patients with routine follow-ups in our clinic * caregivers can be reach by phone exclusion criteria: * patients' ages under 3 and over 18 years --caregivers cannot be reach by phone * caregivers without quality of life results for the pre-pandemic period
safety study of two repeat doses of rt001 for the treatment of moderate to severe lateral canthal lines in adults

Conditions: Lateral Canthal Lines; Crow's Feet; Facial Wrinkles

Summary: this study's objective is to evaluate if rt001 is safe and well-tolerated following two (2) sequential applications.

revance is conducting this phase 2 clinical study to establish the safety of two (2) sequential doses of rt001 topical gel at baseline (day 0) and week 4 for the treatment of moderate to severe lcls at rest.

Eligibility criteria:
inclusion criteria: * written informed consent including authorization to release health information * female or male, 18 to 65 years of age and in good general health * willing and able to follow study instructions and likely to complete all study requirements * moderate to severe lateral canthal lines (crow's feet wrinkles) exclusion criteria: * any neurological condition that may place the subject at increased risk with exposure to botulinum toxin type a, including peripheral motor neuropathic diseases such as amyotrophic lateral sclerosis and motor neuropathy, and neuromuscular junctional disorders such as lambert-eaton syndrome and myasthenia gravis * muscle weakness or paralysis, particularly in the area receiving study treatment * active disease or irritation at the treatment areas including the eye and the skin * pregnant, nursing, or planning a pregnancy during the study; or is a woman of child bearing potential (wocbp) but is not willing to use an effective method of birth control * previous participation in a rt001 clinical study * previous treatment with botulinum toxin (any serotype)

Keywords: lateral canthal lines crow's feet facial wrinkles
mckenzie protocol with/without postural control exercises on pain, rom, and disability in low back pain

Conditions: Low Back Pain

Summary: chronic low back pain (clbp) is a prevalent global musculoskeletal disorder associated with significant physical, psychosocial, and economic burdens. the mckenzie method focuses on the use of sustained postures or repeated movements tailored to alleviate pain and restore function. progressive postural control exercise (ppce) is an innovative approach for managing clbp. it combines elements of motor control exercises and resistance training, emphasizing challenges to postural control through phased progression to improve stability and function. the aim of this study is to compare the effects of the mckenzie protocol, both with and without the integration of progressive postural control exercises (ppce), on pain, range of motion, and disability in patients with low back pain. this study utilized a randomized controlled design with two groups. participants were recruited from shaikh zaid hospital using non-probability convenience sampling. the intervention lasted six weeks, with assessments conducted at baseline, three weeks, and six weeks. group a received mckenzie exercises combined with progressive postural control exercises (ppce), while group b was treated with mckenzie exercises alone, without ppce. assessment tools included the numeric pain rating scale (nprs) for pain, the roland-morris disability questionnaire (rmdq) for disability, the oswestry disability index (odi) for disability, and an inclinometer for measuring range of motion.


Eligibility criteria:
inclusion criteria: * patients aged 18-65 years * diagnosed with non-specific low back pain, with symptoms and pain persisting for over 3 months * individuals reporting a pain intensity of at least 4 out of 7 on the 11-point numeric pain rating scale (11-nprs) * individuals scoring 4 or above on the roland-morris questionnaire (rmq) for low back pain exclusion criteria: * pregnancy * chronic low back pain (lbp) due to trauma, structural issues, neurological symptoms, or radiating pain to the lower legs * history of back surgery, spinal tumors, or infections * diagnosed neurological or musculoskeletal disorders unrelated to lbp, including, stroke, parkinson's disease, demyelination disorders, multiple sclerosis

Keywords: low back pain mckenzie exercise progressive postural control exercise