Kornimate/medical-research-clean huggingface dataset:
dental support device during breastfeeding as a mean for pain control

Conditions: Breastfeeding

Summary: leboride is a dental support device that was developed for reducing pain during active labor. it is made of an inert material, placed in the woman's mouth and does not disturb breathing, talking, or any other activity expected during labor. it is a single-use device, each user receives a new one. this study hypothesis is that the leboride use can reduce pain during breastfeeding, by that improve women's breastfeeding experience, and increase breastfeeding rates.

dental support device is effective in increasing isometric force in different muscle contraction \[1-7\]. in 2009 an avant-garde study \[8\] found in a small cohort that dental support device during labor, can shorten the second stage and reduce obstetrical interventions such as operative delivery and cesarean section. in this stage the woman has to contract muscles in order to push the fetus through the birth canal. leboride is a dental support device that was developed for reducing pain during active labor. it is made of an inert material, placed in the woman's mouth and does not disturb breathing, talking, or any other activity expected during labor. it is a single-use device, each user receives a new one. this study hypothesis is that the leboride use can reduce pain during breastfeeding, by that improve women's breastfeeding experience, and increase breastfeeding rates.

Eligibility criteria:
inclusion criteria: 1. maternal age 18-45 years. 2. normal vital signs. exclusion criteria: 1. contraindications for breastfeeding. 2. significant systemic disease that cause pain or require chronic pain relief.
secox as neoadjuvant therapy in patients with locally advanced hcc

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to evaluate the resectability after treatment with secox (sorafenib, capecitabine, oxaliplatin) as neoadjuvant therapy in patients with locally advanced hepatocellular carcinoma


Eligibility criteria:
inclusion criteria: * hcc confined to single lobe of non-cirrhotic liver (locally advanced) and not suitable for surgery or loco-regional therapies at the time of study entry, but can become resectable after treatment * diagnosis of hcc confirmed by histology * child-pugh class a cirrhosis with adequate remnant liver parenchyma * measurable disease * fit enough to undergo surgery to resect the primary liver tumour exclusion criteria: * prior systemic therapy for hcc * presence of extrahepatic metastasis * history of liver transplantation * peripheral sensory neuropathy with functional impairment * uncontrolled hypertension/ cardiac disease
a random controlled test (rct): acupuncture treatment on nonspecific low back pain (nlbp)

Conditions: Low Back Pain

Summary: hypothesis: acupuncture procedure of he's santong methods could be an option to treat nonspecific low back pain.

he's santong methods is a combined manipulated needling methods, including filiform needling, fire needling and bloodletting needling, which was created by dr. he puren who is one of the most famous tcm doctors in china.

Eligibility criteria:
inclusion criteria: * the patient who is suffering the non-specific low back pain which meets the diagnostic criterion of posterior ramus of lumbar spinal nerve syndrome. * the patient who is from 18 to 79 years old. * the patient who can comprehensively understand and fill in the questionnaires about the disease. * the patient who suffered problems no less than 12 weeks. * the patient who have not the other diseases which can result in back pain. * the patient who received the clear examinations of x-ray, ct scan or mri. * the patient who wrote the informed consents. exclusion criteria: * the patient whose low back pain is the consequences of spondyloschisis, spondylolysis, osteoarthritis, osteoporosis, internal disease, metastatic tumor. * the patient who have the hemorrhagic disease such as hemophilia. * the patient who have the spinal diseases which have not been diagnosed clearly.

Keywords: low back pain acupuncture rct
hepatitis c antiviral resistance in african-americans

Conditions: Hepatitis C

Summary: this study is designed to test the hypothesis that african-americans respond less well to combination pegylated interferon and ribavirin therapy than caucasian-americans who have chronic hepatitis c genotype 1 and who were not previously treated with either interferon or ribavirin. reasons for differences in response, regardless of race, will be studied.


Eligibility criteria:
inclusion: * age between 18 and 70 years at screening * black/african american or white/caucasian * born in the united states * quantifiable serum hcv rna * hepatitis c genotype 1 * liver biopsy consistent with chronic hepatitis c * negative urine pregnancy test * males and females must be using two reliable forms of effective contraception while on drug and during follow-up. exclusion: * previous treatment with interferon or ribavirin * positive test at screening for anti-hiv * positive test for hbsag * alcohol consumption of more than two drinks/day * history of other chronic liver disease * pregnant or breast-feeding women * male partners of women who are pregnant or contemplating pregnancy * neutrophil count \<1000 cells/mm3 * hgb \<11 g/dl in women or 12 g/dl in men * platelet count \<75,000 cells/mm3. * thalassemia, spherocytosis, history of gi bleeding or those at increased risk of anemia * serum creatinine level \>1.5 times the upper limit of normal at screening or crcl \< 75cc/min * current dialysis * alcohol or drug abuse within 6 months * current (\<6 months)severe psychiatric disorder * history of immunologically mediated disease * decompensated liver disease * high risk cardiovascular/coronary artery disease * severe seizure disorder or anticonvulsant use * solid organ or bone marrow transplantation * thyroid disease poorly controlled on prescribed medications * history or other evidence of retinopathy * chronic use of oral steroids * inability or unwillingness to provide informed consent or abide by the study protocol

Keywords: hepatitis c interferon ribavirin efficacy viral load genetics cytokines immunology
id of prognostic factors in mycosis fungoides/sezary syndrome

Conditions: Mycosis Fungoides; Non-Hodgkin's Lymphoma

Summary: the purpose of the study is to develop a prognostic index model for the rare disease of mycosis fungoides and sezary syndrome. this will be done by collecting standardized clinical data at various institutions. the investigators hope this will enable the identification of low- and high-risk groups for survival in order to improve patient care and outcome.


Eligibility criteria:
inclusion criteria * diagnosis of advanced stage mf or ss (stages iib - ivb) within 6 months of presentation to the participating center * patients that are expected to have care administered at the participating center or jointly with referring physician(s) where follow-up data would be available exclusion criteria * patients diagnosed with early stage mf/ss (stages ia-iia) before progressing to advanced stage * patients diagnosed with advanced mf/ss more than 6 months prior to initial presentation to the participating center * exclude one-time consultation type of new patients.
step: enhanced physical activity in children and youth with epilepsy

Conditions: Epilepsy

Summary: epilepsy is common in childhood. children with epilepsy are at increased risk of impaired health, functioning, psychological well-being, and quality of life. there is compelling evidence that physical activity improves the medical and psychosocial aspects of health in adults with epilepsy - but there are no such studies in children. this study is to see if increased levels of physical activity can influence children's functioning, psychological well-being, and quality of life.

there are many unfounded assumptions about the dangers of exercise in children with epilepsy - assumptions that may be seriously detrimental to children's health, and that we have good reason to challenge. this project explores the innovative idea that enhancing physical activity in children with epilepsy will have a positive effect on medical and psychosocial outcomes. the primary purpose of this study is to examine whether increasing physical activity levels through a six-month walking program, that includes behavioral counselling and self-monitoring of physical activity, as compared to varied un-standardized current practices, positively influences health and quality of life over one year. the secondary purposes are to (i) determine which environmental and personal facilitators and barriers to physical activity are experienced when increasing physical activity levels through a six-month walking program; (ii) determine if physical activity levels established during the six-month program will be sustained over a subsequent six-month period that includes self-monitoring of physical activity only; (iii) identify aspects of health that are amendable to change with enhanced physical activity, and explore the relationships among physical activity and impairments, functioning, psychological well-being and quality of life; and (iv) assess if there is a dose-response relationship between physical activity and a variety of health and social factors and quality of life.

Eligibility criteria:
inclusion criteria: * has epilepsy, as confirmed by a pediatric neurologist, with at least 1 seizure in the previous 12 months * ambulatory * fluency english or french * intellectual functioning at or greater than grade 3 level, as judged by parents * access to a computer exclusion criteria: * additional diagnoses of psychogenic seizures or autism * enrolled in a potentially confounding trial

Keywords: physical activity epilepsy children motivation
improvement of peritoneal catheter placement in vps with a splitable trocar

Conditions: Hydrocephalus

Summary: this study is a phase i/iia, single-center, open-labeled, randomized, controlled clinical trial. the aim of this study is to evaluate the safety and efficacy of a modified ventriculoperitoneal catheter placement using a splitable trocar for ventriculoperitoneal shunt.

this study is a phase i/iia, single-center, open-labeled, randomized, controlled clinical trial. patients hospitalized with hydrocephalus will be enrolled and randomly allocated into open mini-laparotomy group (olg) or abdominal puncture group (apg) for insertion of the peritoneal catheter. observe will followed for up to at least 6 months after surgery. the primary endpoint is the rate of overall shunt complication or failure within the first 6 months after surgery, and duration of the abdominal catheterization. the secondary endpoints are rate of distal shunt failure, the overall incidence of various adverse reactions, abdominal incision size, analgesic use as evaluated on day 5 postoperatively, duration of hospital stay. moreover, neurological function of patients (mrs, maxillary hydrocephalus scale) and ct measurement of even index will also be evaluated.

Eligibility criteria:
inclusion criteria: 1. patients aged 18 years or older with new-onset hydrocephalus, including obstructive hydrocephalus, traffic hydrocephalus and special types of hydrocephalus, normal pressure hydrocephalus (nph), idiopathic intracranial hypertension (iih), benign intracranial hypertension, pseudotumor cerebri, etc., regardless of gender. 2. initial diagnosis of hydrocephalus requiring ventriculoperitoneal shunt or shunt failure requiring secondary surgery to replace the shunt. 3. provided written informed consent. exclusion criteria: 1. previous abdominal surgery (except ventriculoperitoneal shunt). 2. pregnancy 3. peritonitis 4. patients with cognitive impairment and inability to communicate. 5. expected survival less than 6 months

Keywords: hydrocephalus ventriculoperitoneal shunt distal shunt failure trocar complications
feasibility of proteomics in chronic lung disease with sarcopenia

Conditions: Sarcopenia; Chronic Lung Disease

Summary: sarcopenia, the loss of muscle mass and strength with ageing, is a prevalent condition in older adults, particularly those with chronic lung diseases like copd and interstitial lung disease. the condition exacerbates the decline in physical ability, leading to decreased mobility, impaired quality of life, and increased disability. sarcopenia's prevalence varies across populations, estimated to affect up to 10% of adults over 60 worldwide, with higher rates reported in studies employing consensus definitions of sarcopenia. the prevalence is even higher in patients with chronic lung diseases, reaching up to 26.6%. sarcopenia's impact on health-related quality of life has been widely investigated. the condition is associated with various comorbidities, including chronic heart failure, obesity, diabetes, and chronic kidney disease, all negatively impacting the quality of life. the proposed study's primary aim is to assess the feasibility of the facs (finding, assessing, confirming, severity) approach in determining sarcopenia's prevalence in the chronic lung disease population. facs includes screening, strength measurements, and bioelectrical impedance analysis (bia) to confirm sarcopenia. the study will also explore potential mechanisms associated with sarcopenia in this population, using proteome and single-cell transcriptome profiles. these multi-omics approaches provide a comprehensive view of the cellular and molecular changes underlying sarcopenia.in particular, the study will evaluate patient acceptance, time efficiency of each test, and recruitment effectiveness. the outcomes will guide the design and execution of subsequent, larger studies and provide preliminary data for power calculation for the full-scale study.


Eligibility criteria:
inclusion criteria: 1. adult patients diagnosed with chronic lung disease (≥ 18years). 2. only patients who are willing and able to provide informed consent to participate in the study. exclusion criteria: 1. patients with other major comorbidities that could significantly impact muscle mass and function, such as severe heart failure, advanced liver or kidney disease, uncontrolled diabetes, or malignancies. 2. patients with acute exacerbations of their chronic lung disease or any other acute illness at the time of the study. 3. patients with a history of neuromuscular disorders or disability that could significantly affect muscle mass and function. 4. patients who have undergone recent surgery in the past 6 months or have received specific treatments that could influence muscle mass and function, such as long-term corticosteroid use, chemotherapy, or radiation therapy. 5. patients with life expectancy of less than 6 months 6. patients who are unable or unwilling to comply with the study protocol or procedures. 7. patients that are unable to give informed consent.
mater-bronx rapid hiv testing project.

Conditions: Human Immunodeficiency Virus

Summary: in the m-briht study we aim to implement a programme of opportunistic hiv screening in the emergency department, mater misericordiae university hospital. we hypothesize that such a programme will be acceptable in an irish setting. we also wish to study the factors that influence test completion or acceptance. we will utilise informative interactive video media via a touch-screen tablet device to provide pre-test counselling and then offer rapid minimally invasive testing with a cotton-bud type swab of the buccal mucosa. in doing so we will to determine absolute numbers of those attending the ed who consent to watching the interactive information video about rapid hiv test screening. we will describe the absolute number and proportion of those who watch the interactive video who subsequently proceed to have the rapid hiv test. the primary aim is to determine the cultural, gender and ethnic factors which influence the completion of such rapid hiv testing with the future objective of maximising test completion in this crucial public health area.


Eligibility criteria:
inclusion criteria: * all adults greater than 18 years of age who present to the emergency department, mater misericordiae university hospital * must have capacity to consent to watch an interactive video tablet device about hiv and hiv screening test. exclusion criteria: * hiv positive patients (known previous hiv positive patients). * acute intoxication in which capacity is impaired * critically unwell patients who require active or intensive resuscitation. * acute psychiatric disturbance in which capacity is impaired

Keywords: emergency medicine screening point of care testing video assisted counseling
hybrid intraprocedural imaging based on 2 different imaging methods

Conditions: Angina Pectoris; Left Ventricular Wall Motion Abnormalities

Summary: the investigators will check the feasibility of an intraprocedural vitality diagnostics and the identification of an indication for percutaneous transluminal coronary angioplasty (ptca).

after myocard vitality diagnostics with mri patients will underwent additionally an stress echocardiography within the exploration. by this ultrasound we will measure the lv mass and the ejection fraction per apical 2-, 3- and 4-chamber view. in addition a 2d-strain-analysis will be done to measure the systolic and diastolic strain and also the circumferential and radial strain rate parameter (by depicting three parasternal short axis views in the basal, mid-ventricular and apical plane). these measurements will be compared with the studies-conditioned mri-finding (as reference) to find the optimal strain-parameter and the optimal cut-off-data for an intraprocedural vitality diagnostics of the single layers (endocardial, myocardial, and epicardial) for this patient group. the data upraised through this are compared off-line to the mri findings.

Eligibility criteria:
inclusion criteria: * left ventricular wall motion abnormalities * existent myocardial vitality mri exploration * reduced lv-function * steady angina pectoris * patients which are legally competent and which are mentally able to understand the study staff * patients give their written consent exclusion criteria: * pregnancy or lactation * acute or instable angina pectoris * acute myocardial infraction in the last 3 month

Keywords: coronary stenosis angina pectoris left ventricular wall motion abnormalities
investigating the effects of osteopathic manipulative treatment on stress management in medical students

Conditions: Stress, Job; Student Burnout; Stress, Physiological; Stress, Psychological

Summary: the goal of this clinical trial is to evaluate stress biomarkers, subjective stress levels, and cognitive function in medical students. the main question\[s\] it aims to answer are: does regular osteopathic manipulative treatment affect stress in medical students? does regular osteopathic manipulative treatment affect cognitive function in medical students? participants will be split into two groups, control and treatment, and undergo a designated protocol for six weeks. the treatment protocol will include weekly sessions of three omt techniques: paraspinal inhibition, rib raising, and condylar decompression. concurrently, participants' salivary cortisol levels will be collected weekly and analyzed using an invitrogen elisa immunoassay kit. additionally, cognitive function will be assessed weekly via lumosity, while stress levels are gauged using the college student stress scale (csss) survey. researchers will compare one cohort of medical students who receive weekly omt and another cohort of medical students who have weekly check-ins without omt to see if omt can affect changes in stress biomarkers, subjective stress scales, and cognitive function.


Eligibility criteria:
inclusion criteria: * first-year medical students * not currently receiving osteopathic manipulative treatment (omt) exclusion criteria: * pregnant * history of spinal surgery

Keywords: osteopathic manipulative medicine osteopathic manipulative treatment omm omt cortisol medical student stress cognitive function
the examination of relationship between self-efficacy in people with chronic low back pain

Conditions: Self Efficacy

Summary: self-efficacy is defined as a person's confidence or belief that one can achieve a certain behavioral or cognitive state. self-efficacy is one of the most important assesment parameters in the self-management model. it is accepted that patients with chronic low back pain with high self-efficacy have a better prognosis than those with low self-efficacy. due to the complex nature of pain; the relationship between psychological and physical parameters such as pain catastrophy, disability level, depression, physical performance, self-efficacy, pain intensity and fear avoidance arouses curiosity. the aim of this cross-sectional study is to examine the relationship between the level of self-efficacy and sensory, perceptual and motor skills in people with chronic low back pain.


Eligibility criteria:
inclusion criterias for healthy group: * being minimum 30 maximum 65 years old * to be literate * accepting to take part in the study inclusion criterias for partipicians with low back pain group: * being minimum 30 maximum 65 years old * minimum 3 score from visual analog scale (vas) * having low back pain for at least 3 months of time * to be literate * accepting to take part in the study exclusion criteria: * any kind of surgery in low back area * surgery story in lower extremities * acute low back pain * having a neurological disorder * having a rheumatological disease which may cause to low back pain * having a herniated disc that presses on the sacral nerves * being pregnant

Keywords: back pain propioception depression pain catastrophizing flexibility balance