Kornimate/medical-research-clean huggingface dataset:
could bisphenol-a have a role in the etiology of neural tube defects

Conditions: Neural Tube Defects; Bisphenol-A

Summary: our aim in this study is in patients with a diagnosis of neural tube defect; is the measurement of bpa levels in maternal blood and amniotic fluid.

this prospective observational study was conducted with 92 patients aged 18 - 45 years who had amniocentesis at 15 - 22 weeks of gestation at bursa yüksek i̇htisas training and research hospital between april 15, 2021 and april 15, 2022. patients were divided into two groups according to amniocentesis indications. group 1: patients with abnormal maternal serum screening test or prenatal diagnosis test, patients with abnormal ultrasonography findings (45 patients), group 2: patients with pre-diagnosis of ntd (47 patients). during the amniocentesis procedure, the first 5cc amniotic fluid and maternal serum samples were collected from the patients. the obtained samples were stored at -80°c until the end of the study. after all samples were collected, bpa values were measured by elisa method.

Eligibility criteria:
inclusion criteria: * patients who had a single pregnancy, had a pre-diagnosis of neural tube defect or had amniocentesis between 15 and 22 weeks of age with other indications * patients had an uncomplicated pregnancy before the procedure * patients had no vaginal infection exclusion criteria: * multiple pregnancies, * pregnant women who developed complications due to amniocentesis * pregnant women with known infective or autoimmune diseases before pregnancy * those whose spouses or themselves worked in the plastics industry * patients who could not obtain enough amniotic fluid despite meeting the study criteria during the study

Keywords: bisfenol a amniocentesis neural tube defect
prevalence of diabetes in patients who are candidates for spine surgery

Conditions: Spine Disease

Summary: the purpose of the study is to assess, through systematic screening, the prevalence of diabetes or prediabetes in patients who are candidates for lumbar spine surgery.

this is a prospective, longitudinal, single-center, open-label observational study on a population of patients undergoing lumbar spine surgery. this study does not alter patient management or the physician-patient relationship. assessments take place during routinely scheduled consultations. fasting blood glucose and glycated hemoglobin measurements are part of the standard preoperative assessment. patient self-administered questionnaires are routinely completed for practice evaluation purposes and constitute a database for routine care.

Eligibility criteria:
inclusion criteria: * adult patients, * patients who have been informed of the research and have not indicated their opposition to the use of their medical data, * patients who are candidates for their first lumbar spine surgery, whether instrumented or not exclusion criteria: * non-instrumented percutaneous surgery (cementoplasty) * presence of spinal osteosynthesis equipment * surgery performed for an infectious or tumoral spinal condition * surgery via an anterior or lateral approach

Keywords: spine surgery diabetes
ess as a diagnosis resource aid of the syndrome of obstructive sleep apnea

Conditions: Sleep Apnea; Mixed Central and Obstructive Sleep Apnea; Sleep-Disordered Breathing

Summary: the aim of this study was to analyze the effectiveness of the epworth's sleepiness scale as a recourse aid in the diagnosis of the syndrome of obstructive sleep apnea. 475 patients attended this study, that sought the cesf to probable diagnosis of some sleep disorder. the data were collected from records, wich are of questionnaires, including the ese, prepared by the cesf professionals and responded, previously, by the own patients. the study compared the result obtained in the scale of epworth with the data of polysomnography. the analysis of data was performed using the spss, based on descriptive and inferential statistics, being used the average considering the standard deviation, and, to the crossing of variables, was used the chi-square test of pearson, considering as significant statistically values of p\<0.05. the results showed that gender, age and bmi are predisposing factors to sosa.


Eligibility criteria:
inclusion criteria: * charts of whose admission of patients was from october 2005 to july 2007 * patients referred to the cesf for possible diagnosis of a sleep disorder exclusion criteria: * incomplete data * patients with concomitant diseases (heart disease, hormonal disease, chronic obstructive pulmonary disease and neurological patients) * patients undergoing uvulopalatopharyngoplasty

Keywords: evaluation obstructive sleep apnea polysomnography
mri t2* mapping of myocardium, liver, pancreas and pituitary gland

Conditions: Iron Overload

Summary: all patients were investigated using a 3t mri and 1,5 t mri scanners. for myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for t2\*-mapping. miocardium, pancreas and pituitary gland t2\* relaxometry maps were calculated automatically by commertial application reportcard functool (ge healthcare) and integrated philips t2\* maps. then for selected roi t2\* data acquisition in milisecond \[ms\] were performed and calculated automatically.

all patients were investigated using a 3t mri scanner (philips achieva) and 1,5 t mri scanner (ge signa) with 8-channel surface coil for body scanning. for myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for t2\*-mapping based on fast gradient echo sequences - multi-phase fast gradient echo and ultrashort gradient echo (ute) in axial and coronary plane. for breath-hold acquisition due to failure of communication and invariable behavior some children received anaesthetic support with mechanical ventilation. miocardium, pancreas and pituitary gland t2\* relaxometry maps were calculated automatically by commertial application reportcard functool (ge healthcare) and integrated philips t2\* maps. the placement of region of interest (roi) in target organ were performed by following criterion: for the myocardium - in the interventricular septum in short axis plane; for the pancreas - in corpus in axial plane; for the pituitary gland - in adenohypophysis; for all organs the area of large and small blood vessels, which can introduce distortions of the obtained results were excluded. then for selected roi t2\* data acquisition in milisecond \[ms\] were performed and calculated automatically by approximating the attenuation curve with the highest likelihood method.

Eligibility criteria:
inclusion criteria: 1. age under 25 y.o.; 2. a history of transfusion-dependent anemia of various origins. 3. indications for the appointment of chelation therapy non-inclusion criteria: 1. age over 25 y.o. 2. the number of rbc transfusions previously received by the patient is less than 10 exclusion criteria: 1. absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.); 2. refusal to sign the informed consent.

Keywords: iron t2* mapping mri relaxometry transfusion
mec90 for supra-inguinal fascia iliaca block performed under ultrasound guidance in arthroscopic knee surgery

Conditions: Pain Management

Summary: in this study, the minimum effective concentration required for supra-inguinal fascia iliaca block applied in patients undergoing arthroscopic knee surgery is aimed. the same volume will be used in all of the block applications in the study, and the local anesthetic concentration used will be determined by increasing or decreasing according to the success of the previous block. the primary goal of the study is block success.

for patients included in the study, 40 ml of local anesthetic will be used for sifib. the local anesthetic concentration will be randomized using the biased-coin design up-down sequential method, as suggested by durham et al. and described by dixon. the primer outcome of this study is block success. also, the incidence of motor block formation in the quadriceps muscle (to be defined as paresis or paralysis in knee extension), the amount of tramadol needed in 24 hours, opioid-related side effects (postoperative nausea/vomiting, itching), length of hospital stay and complications that may develop related to the block will be recorded.

Eligibility criteria:
inclusion criteria: * patients undergoing arthroscopic knee surgery under spinal anesthesia will be included in the study. exclusion criteria: * conditions where regional anesthesia is contraindicated (coagulopathy, infection..) * patients who underwent general anesthesia for the surgical procedure * patients who do not want to be included in the study by not signing the voluntary consent form. * patients with advanced dementia, orientation-cooperation problems * history of allergy to local anesthetic drugs * infection status at the injection site
dual diagnosis (psychosis and cannabismisuse): comparison of specialized treatment versus unspecified treatment

Conditions: Psychotic Disorders; Marijuana Abuse; Intervention

Summary: intention of the study is to examine, if the symptomatology of dual diagnosis patients is less severe after a special indication training for reduction of cannabis consumption in comparison to unspecified trainings. point of interest is psychopathology and consumerism.

dual diagnosis patients (psychosis and cannabis abuse) account for more clinical admissions than single diagnosis patients. cannabis misuse is a known risk factor for recurrence of psychosis. a specified intervention on the basis of a manual for schizophrenic substance abusers is administered to inpatients in a specialized unit for young schizophrenic patients in a psychiatric hospital. the control group, same indication (psychotic disorder and cannabis misuse) receives social competence training (specified for schizophrenic patients as well). admission to groups is randomly.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia and disorders with psychotic features * misuse of cannabis during 12 months preceding admission to hospital exclusion criteria: * not able to attend training twice a week for 45 minutes (concentration, attention, psychotic symptoms, agitation) * discharge from hospital before completion of training

Keywords: psychotic disorders cannabis intervention
maternal cardiac output response to rescue norepinephrine and phenylephrine boluses in patients with severe preeclampsia

Conditions: Hemodynamic Instability

Summary: the purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

preeclampsia, which affects 5% to 7% of parturients, is a significant cause of maternal and neonatal morbidity and mortality. because of constricted myometrial spiral arteries with exaggerated vasomotor responsiveness, though blood pressure in parturients with preeclampsia are apparently higher than healthy parturients, placental hypoperfusion is more common. spinal anesthesia is still the preferred mode of anesthesia in parturients with preeclampsia for cesarean section. in preeclampsia parturients, spinal anesthesia improve intervillous blood flow (provided that hypotension is avoided) which contribute to increase placental perfusion. even so, 17-26% parturients with preeclampsia experienced postspinal anesthesia hypotension due to the extensive sympathetic block that occurred with spinal anesthesia. as a potential substitute drug for phenylephrine and ephedrine, norepinephrine has gained traction for use in parturients undergoing cesarean section. however, hemodynamic effects of the rescue norepinephrine bolus is still unknown. the purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

Eligibility criteria:
inclusion criteria: * 18-45 years * primipara or multipara * singleton pregnancy ≥32 weeks * american society of anesthesiologists physical status classification ii to iii * scheduled for cesarean section under spinal anesthesia exclusion criteria: * baseline blood pressure ≥180 mmhg * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension * hemoglobin \< 7g/dl * fetal distress, or known fetal developmental anomaly

Keywords: cardiac output response norepinephrine phenylephrine preeclampsia cesarean section
efficacy of kerecis omega 3 in comparison to clinical standard procedures

Conditions: Leg Ulcer

Summary: chronic leg ulcerations are a great burden for patients and the medical system alike. frequent outpatient consultations with associated treatment costs and travel costs for the patient as well as psychosocial burdens remain an unmet problem in chronic wound care. there is an increasing need for definitive treatment of especially chronic venous and multifactorial chronic leg ulceration where arterial intervention is not a treatment option. minimal invasive surgical interventions that do not require skin grafting can be performed under local anesthesia in an outpatient setting even in multimorbid patients. kerecis omega3 wound is intact decellularized fish skin. the fish skin sheets contain fat, protein, elastin, glycans and other natural skin elements and it can be an effective treatment option in chronic leg ulcerations and is licensed for this use as a medical product in switzerland. however, limited data without inter-wound bias is available for the use of kerecis omega 3 in chronic leg ulcerations. in this study the investigators propose to investigate the efficacy of kerecis omega 3 according to objective wound surface measurements using standardized digital photographs in patients with chronic leg ulcerations. efficacy will be evaluated against standard of care wound debridement.


Eligibility criteria:
inclusion criteria: * any chronic leg ulcer \> 4 weeks duration with delayed wound healing (reduction of wound surface of less than 40-50% within 4 weeks under adequate local therapy) without underlying treatable medical conditions * ulcer area at between 5cm2 and 60cm2 * bacterial swab sampling prior to study * written study informed consent exclusion criteria: * history of fish allergy or proven fish allergy * pregnant or breast-feeding women * intention to become pregnant during the course of the study * wound not suitable for dressing: inflammation, fibrin coatings * inability to understand the study consent
european study of cerebral aspergillosis treated with isavuconazole

Conditions: Cerebral Aspergillosis; Invasive Aspergillosis

Summary: study clinical context cerebral aspergillosis (ca) is a rare location of invasive aspergillosis (ia), associated with a high morbidity and mortality. since 2002, voriconazole is the recommended first line treatment of invasive aspergillosis. more recently, isavuconazole appeared to be not less effective than voriconazole in the treatment of filamentous ifi, with a better tolerance profile. the investigators aim to evaluate better the efficacy and the safety of isavuconazole in the treatment of cerebral aspergillosis by a descriptive, multicentric, international retrospective cohort study.


Eligibility criteria:
inclusion criteria: * proven or probable cerebral aspergillosis according to the eortc criteria modified by adding diabetes in the host criteria * in child or adult * treated by isavuconazole at least 7 days * diagnosed between march 2017 and june 2020 exclusion criteria: * possible cerebral aspergillosis * isavuconazole treatment for less than 7 days

Keywords: cerebral aspergillosis isavuconazole
upper extremity dysfunction in patients with cervical radiculopathy

Conditions: Cervical Radiculopathy

Summary: this study will examine how cervical radiculopathy (a pinched nerve in the neck) affects function in both arms, not just the symptomatic side. the investigators will evaluate 42 patients with different cervical nerve root involvement (c4-5, c5-6, or c6-7) and compare them to 16 control subjects with non-specific neck pain. the assessments will measure muscle strength, sensory function, hand performance, pain levels, and psychological factors. these evaluations may contribute to the development of rehabilitation programs for cervical radiculopathy.


Eligibility criteria:
inclusion criteria: * age 18-65 years * clinical diagnosis of unilateral cervical radiculopathy at c4-5, c5-6, or c6-7 level * diagnosis confirmed by clinical examination and mri * symptoms present for at least 4 weeks prior to enrollment * ability to understand and follow study instructions * ability to provide informed consent for participation * for control group: non-specific neck pain without radiculopathy * ability to complete required assessments exclusion criteria: * systemic disorders * neurological disorders (excluding cr) * previous spinal surgery * acute trauma * fracture * malignancy * osteoporosis * rheumatic disease * ongoing pharmacological treatment for chronic neck pain
pms study of silver i alginate non-woven dressing (hydro-alginate)

Conditions: Wound

Summary: post market surveillance study to confirm the ongoing safety and performance of silver i alginate non-woven dressing (hydro-alginate) in chronic and acute wounds.

design: the design of the study is an open-label, multicentre, single arm clinical trial in subjects with moderate to heavily exuding chronic and acute wounds consisting of pressure ulcers and donor sites. the rationale for the chosen study design and objectives is based on the requirement for further confirmation of the clinical effectiveness and safety of the dressing in routine clinical use, in terms of management of wound, management of bioburden, maintaining a moist wound environment, and exudate management. this post market study has been designed to be an in-market clinical evaluation. using the assessment scale of "satisfactory" or "not satisfactory" will indicate whether the device is acceptable to the healthcare professional and therefore demonstrate the acceptability of the silver i alginate non-woven dressing (hydro-alginate). it is intended to recruit 25-30 subjects per wound type in support of providing evidence of effectiveness and safety of wound dressings. the prior ce-marking evaluation for this device lacked information pertaining to the use of the device in pressure ulcers or donor site wounds. therefore, this study will address this gap. this study analysis will be descriptive in nature, for each wound type and will not be based on any stand-alone statistical hypotheses. the study endpoints have been chosen because they will demonstrate the safety and effectiveness of the dressing in routine clinical use.

Eligibility criteria:
inclusion criteria: 1. males or females, age 18 years or above. (females must not be pregnant and if of reproductive age should provide a negative pregnancy test at screening). 2. patients who are able to understand and give informed consent to take part in the study. 3. have one or more of the following: pressure ulcer or donor site wounds that are infected, or are at high risk of infection (in the opinion of the investigator), that are moderate to heavy levels of exudate. 4. pressure ulcers that are moderate to high exudate, typically category 3 and 4. 5. only one primary wound may be treated per patient for the study. exclusion criteria: 1. patients who are known to be non-compliant with medical treatment, 2. patients who are known to be sensitive to any of the device components 3. subject is pregnant or actively breastfeeding; 4. subject has a known sensitivity to silver; 5. life expectancy of \<6 months; 6. subject has any significant or unstable medical or psychiatric condition that, in the opinion of the investigator, would interfere with his/her ability to participate in the study; 7. subject is currently enrolled in another clinical study, or has completed a clinical study less than 30 days prior to enrolment.
vestibular socket therapy with simultaneous implant placement versus contour augmentation with early implant placement

Conditions: Loss of Teeth Due to Extraction

Summary: immediate implant placement with vst technique versus early implant placement with contour augmentation in fresh extraction sockets in the esthetic zone.

comparing vst technique with immediate implant placement that end up with final crown after 2 months with contour augmentation with early implant placement after 4- 8 weeks of soft tissue healing , then after 3 months final crown delivery both in fresh extraction sockets in the esthetic zone .

Eligibility criteria:
inclusion criteria: non-restorable maxillary teeth in the esthetic zone intact adjacent teeth adequate palatal and apical bone that allows achieving implant primary stability. compromised sockets type ii defect (nicolas elian 2007) ≥18 years systemically healthy patients exclusion criteria: extraction sockets with acute or chronic infection or with adjacent infected teeth heavy smokers \> than 10 cigarettes daily cancer patients undergoing radiotherapy or chemotherapy during or within the last 6 months. unmotivated patients to maintain adequate oral hygiene to follow up. patients with physical disabilities that could affect follow up.
comparison of mesh fixation wit cyanoacrylate vs suture in inguinal hernia surgery

Conditions: Chronic Pain

Summary: to compare fixation with glubran2 with suture during surgery por primary inguinal hernia. hypothesis: glue may induce less complications and chronic pain than suture


Eligibility criteria:
inclusion criteria: * male patients * aged more than 18 years * primary inguinal hernia exclusion criteria: * inguinoscrotal hernia

Keywords: male patients age > 18 year primary hernia glue
registration of intravenous thrombolysis for acute ischemic stroke in southwestern china（ivtis）

Conditions: Stroke, Acute

Summary: this study aims to observe the safety and effectiveness of intravenous thrombolysis for acute ischemic stroke in real-world clinical practice.

ivtis is a prospective, real-world registry lasting for 22 years. a total of 3000 patients with intravenous thrombolysis will be enrolled。

Eligibility criteria:
inclusion criteria: * the patient was diagnosed with acute ischemic stroke and received intravenous thrombolysis. exclusion criteria: * no additional exclusion criteria.
pcori-cer-1306-03385 lung cancer screening readiness study

Conditions: Lung Cancer Screening

Summary: investigators will administer a brief, anonymous survey at the texas academy of family physicians (tafp) annual primary care summit to better understand the readiness of primary care physicians in texas to implement lung cancer screening programs in their practice settings.

for this project there will be up to 1000 participants. physicians attending the annual cme event at the texas academy of family physicians event will be asked to fill out an anonymous survey to better understand their readiness to implement lung cancer screening programs in their practice settings. the surveys will be administered to physicians attending the tafp education events in houston, texas, october 17-19, 2014 and in dallas, texas, november 7-9, 2014.

Eligibility criteria:
inclusion criteria: 1. physicians attending the tafp education events in houston, texas, october 17-19, 2014 and in dallas, texas, november 7-9, 2014. exclusion criteria: n/a

Keywords: lung cancer screening lcs survey questionnaire texas academy of family physicians