Kornimate/medical-research-clean huggingface dataset:
impact of breast milk on the infectivity and transmission of different viruses "breastmilkvir"

Conditions: Breastmilk Collection

Summary: exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children. however, breast milk and breastfeeding can be significant pathways for the transmission of certain viruses. the objective of this study is to examine the influence of human breast milk and its composition on viral infectivity and viral transmission of the htlv-1 virus and arboviruses such as zika virus, yellow fever, dengue, and tick-borne encephalitis.

exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children. however, breast milk and breastfeeding can be significant pathways for the transmission of at least three human viruses: htlv-1, hiv, and human cytomegalovirus (cmv). to address the following main objective: to study the influence of human breast milk and its composition on viral infectivity and viral transmission of the htlv-1 virus and arboviruses such as zika virus, yellow fever, dengue, and tick-borne encephalitis.the study plans to collect milk samples from lactating women who are registered with the lactarium of île-de-france to donate their breast milk.

Eligibility criteria:
inclusion criteria: * age \> 18 years * female gender * lactarium ile-de-france donors * subjects covered by a social security scheme, excluding state medical aid no inclusion criteria: - women opposing participation in the study exclusion criteria: - positive hiv, hbv, hcv and htlv serologies (lactarium exclusion criteria)

Keywords: milk maternal virus transmission infectivity
the registry of genetic alterations of taiwan biliary tract cancer

Conditions: Biliary Tract Cancer (BTC)

Summary: recent progress in comprehensive genomic profiling for advanced btc has helped to clarify tumorigenesis and facilitate the coming era of precision medicine. to further elucidate the underlying molecular genomic aberrations, as well as the clinical demographics and therapeutic outcomes, it is necessary to have a national, multi-centers and population-focused research project to collect data completely. tumor tissue will be collected from advanced btc patients for real-time next-generation sequencing analysis in a platform of data storage and sharing. the purpose of the precision medicine project is to establish tumor molecular profiling of btc populations in taiwan, to facilitate patients to have corresponding potential targeted therapeutics and suitable clinical trials.

biliary tract cancer (btc) compromises a heterogenous group of tumors with poor prognoses. curative surgery remains the first choice for localized disease; however, most btc patients had unresectable or metastatic disease. the gold standard therapy for these patients is chemotherapy with gemcitabine and cisplatin. there are no consensus guidelines for standard treatment in a second-line setting, although the data of the abc-06 trial showed a slight survival benefit from oxaliplatin and 5-fluorouracil combination chemotherapy. recent progress in comprehensive genomic profiling for advanced btc has helped to clarify tumorigenesis and facilitate the coming era of precision medicine. to further elucidate the underlying molecular genomic aberrations, as well as the clinical demographics and therapeutic outcomes, it is necessary to have a national, multi-centers and population-focused research project to collect data completely. tumor tissue will be collected from advanced btc patients for real-time next-generation sequencing analysis in a platform of data storage and sharing. the purpose of the precision medicine project is to establish tumor molecular profiling of btc populations in taiwan, to facilitate patients to have corresponding potential targeted therapeutics and suitable clinical trials.

Eligibility criteria:
inclusion criteria: 1. ages 20 and above. 2. pathological reported showed adenocarcinoma or adenosquamous carcinoma for patients with btc (include ihcc, ehcc, gbc or avc) or hepatocholangiocarcinoma as locally advanced or metastatic status. 3. willingness to provide the residual biopsy/operative slides. 4. life expectancy more than 3 months. 5. patients fully understand the protocol with the willingness to have regular follow-up. 6. patients are ready to have 1st systemic treatment or under 1st line therapy 7. total bilirubin ≦5 mg/dl, and ecog≦2 exclusion criteria: 1. inability to cooperate by providing a complete medical history. 2. no available tumor tissues for genetic testing. 3. undesirable compliance. 4. other malignancy within the past 1 years except adequately treated basal or squamous cell skin cancer or cervical cancer in situ.

Keywords: biliary tract cancer next-generation sequencing precision medicine
investigation of the psychometric properties of the squares test in measuring hand function in parkinson's disease

Conditions: Parkinson Disease

Summary: the first aim of the present study was to investigate reliability, validity and responsiveness to the minimal clinically important difference, which is defined as the smallest change in score corresponding to clinically meaningful change realized by patient, of the squares test in people with pd. the second aim of the study is to determine the relationship between hand function and both trunk control and balance in pd population.

at baseline, the st, unified parkinson's disease rating scale (updrs), hoehn and yahr (h\&y) scale, berg balance scale (bbs) and trunk impairment scale (tis) was applied to the ps group when the patients were "on" period. the st was repeated after seven days from the first application when pd group were "on" period to evaluate its reliability.

Eligibility criteria:
inclusion criteria: * at least 40 years of age * neurologist-diagnosed idiopathic pd (using uk brain bank criteria) * hoehn \& yahr (h\&y) stages 1 to 4 * mini-mental state examination ≥ 22/30 (literate and with 5 or more years of education) and ≥18/30 (illiterate and with less than 5 years of education) * living in the community exclusion criteria: * individuals with other major diseases (e.g., cancer, stroke, epilepsy, dementia, and severe rheumatoid arthritis) * preexisting disabilities * visual impairments * diagnosis of atypical parkinsonism * h\&y stage 5 * previous surgical management of pd

Keywords: parkinson's disease hand function squares test
spinal prilocaine for caesarian sections

Conditions: Combined Spinal Epidural Anesthesia; Prilocaine; Bupivacaine; Pain

Summary: prilocaine theoretically could provide faster onset because of its lower pka (7,7) compared to bupivacaine (8,1). the primary objective of this prospective double blind randomized trial is to determine block onset of spinal hyperbaric prilocaine compared to bupivacaine, both with a small dose of sufentanyl as an additive.the primary hypothesis is that a significant larger amount of patients will gain surgical readiness within 8 minutes after spinal injection of prilocaine with sufentanyl compared to bupivacaine with sufentanyl. surgical readiness is defined as a sensory block level of t5 tested by loss of cold sensation.

this study is designed as a randomised prospective double blind multi centre study. following approval by the hospital ethics committee of the university hospital antwerp and all participating hospitals, all-in term (37-42 weeks of gestation) pregnant women planned for a caesarean section will be asked to participate in this trial. patients will be randomised to receive either spinal prilocaine with sufentanyl or spinal bupivacaine with sufentanyl.the patient, the anaesthetist performing the cse and the observer are not aware of the local anaesthetic solution administered. preoperative a combined spinal epidural puncture will be performed in the sitting position at the level of l2-l3 or l3-l4 . vital parameters will be registered at regular intervals. block characteristics ( onset, duration and intensity of the sensory block and motor block) will be measured at regular intervals. patients with insufficient analgesia will receive a top up dose of 5 ml lidocaine 2 % via the epidural catheter. time of birth, neonatal outcome (apgar score 1 min, 5 min and 10 minutes after birth) and admission to the nicu as well as umbilicus venous and arterial blood gasses are recorded. patients will be discharged from the pacu when motor block reached a bromage score 1 time intervals of discharge to the ward will be registered.at the maternity ward the time of first contact of the baby and the mother and first breast feed (if applicable) will be registered. one week postoperative patients will be called and asked if they experienced any postoperative symptoms like headache, micturition problems or symptoms resembling transient neurological symptoms

Eligibility criteria:
inclusion criteria: * a term pregnant women (37-42 weeks)scheduled for caesarian section exclusion criteria: * patient refusal * twin or multiple pregnancy * preeclampsia * contraindication neuraxial technique * indication general anaesthesia * bmi before pregnancy \>35 * maternal height \<155 cm

Keywords: combined spinal epidural anesthesia caesarian section prilocaine bupivacaine
the study of effectiveness of rtms on rumination and anhedonia in patients with major depressive disorder

Conditions: Major Depressive Disorder; Bipolar Depression

Summary: rumination is significantly frequent in major depressive disorder. however, not a lot of studies have investigated the effects of repetitive transcranial magnetic stimulation on rumination and its electrophysiological correlates. this study recruited 61 participants who were randomly assigned to sham, bilateral, or unilateral stimulation groups to investigate the potential differences between these stimulation protocols and changes in the behavioral and electrophysiological outcomes after treatment.

this study aims to compare the effect of unilateral and bilateral rtms on the reduction of rumination and anhedonia and their associated neural networks. in a randomized double-blind trial, 65 patients with depressive disorder in atieh clinical neuroscience center are assigned to three groups. the first group receives bilateral rtms for 20 sessions on right and left dlpfc; the second group receives unilateral rtms for 20 sessions on ldlpfc; third group receives sham rtms for 10 sessions. in this group, the stimulation parameters are similar to that in the actual rtms group, except that the coil angel is 90° and perpendicular to the head. rumination and anhedonia symptoms will be measured by the ruminative responses scale (rrs) and snaith-hamilton pleasure scale (shaps) in the baseline and after the 20th session. in order to investigate the neural networks associated with rumination and anhedonia, eeg of patients will be recorded at the first session and at the end of the treatment.

Eligibility criteria:
inclusion criteria: * outpatients male and female with the range of 18-65 years of age * the diagnosis of major depressive disorder according to dsm-v * having bdi\>18 * having stable symptoms as defined by not requiring a change in medication for at least 4 weeks * completion of consent form * being under supervision of a psychiatrist exclusion criteria: * the history of rtms treatment for any reason * cardiac pacemaker * the risk of seizure with any reasons * pregnancy * high risk of suicide * intracranial implant and other ferromagnetic materials close to the head

Keywords: mdd rtms rumination anhedonia
ultrasound evaluation of cystic lesions in the knee:in comparison to magnetic resonance imaging

Conditions: Knee Cyst Popliteal (___Cm)

Summary: benign cysts and cystic-appearing lesions in and around the knee are common and differentiation between them through the history, symptoms and clinical examination is difficult due to the presence of common findings such as pain, edema, and palpable mass. the clinical presentation depends on the location, size of the lesion and its relation with the surrounding structures.

the benign knee cysts can be subdivided into four major categories as following:1- synovial cysts, 2- popliteal (baker's) cyst, 3- ganglion cysts, 4- meniscal cysts. whereas, the "cyst-like" lesions can be sub-classified into the following:1- normal knee bursae, 2- normal knee recesses, 3- miscellaneous cyst-like lesions as aneurysms, hematomas, seromas and abscess. many of these lesions have fairly characteristic locations and imaging features. knowledge of these variants and lesions is essential for accurate diagnosis and to avoid mistaking them for aggressive soft tissue lesions, including sarcomas. ultrasonography and magnetic resonance imaging are the most useful imaging modalities in evaluating these benign cystic lesions. ultrasonography can distinguish cysts from solid lesions and assess the degree of vascularity within the lesion. magnetic resonance imaging can help to delineate the location of the lesion in relation to anatomic structures and also determine if the lesion is cystic or solid when contrast is administered.

Eligibility criteria:
inclusion criteria: 1. clinically diagnosed cystic lesions in and around the knee. exclusion criteria: 1. arthroscopy or surgical intervention to the knee joint. 2. fracture repaired by metal plates or screws. 3. claustrophobia. 4. contraindications to mri as patients with implanted pacemaker or defibrillator, ferromagnetic aneurysm clips and metallic foreign body at the knee joint.
in vivo clinical investigation of the safety and performance of dental implants tbr® bone level

Conditions: Edentulous

Summary: partial or total edentulousness has a significant impact on quality of life both functionally and aesthetically. tbr® bone level implants allow the patient to prevent bone resorption and maintain facial tissue and musculature support. at the functional level, the patient who benefits from implant treatment regains normal masticatory function with all the benefits on the quality of life that this can bring him. due to the osseointegration of the implant and the biocompatibility of the materials used, the implant treatment remains effective in the long term and makes it possible to maintain the aesthetics of the smile.

many adults have one or more missing teeth. the negative consequences of partial or total edentulousness are numerous in the orofacial sphere: * edentulousness causes a strong aesthetic deficit due to the lack of support of facial tissues and musculature; * edentulousness generates a functional deficit that can have significant repercussions on the nutritional status of the affected subject; * edentulousness is accompanied by bone resorption of the jawbones which is inevitable in the absence of implant treatment; * in addition, the resulting feelings of discomfort and fragility are experienced as a real psychological handicap by the patient, partially or totally edentulous, which can then have significant repercussions on his social life. tbr® bone level implants are intended for placement in the maxillary or mandibular arch in partially or completely edentulous patients for prosthetic restoration in the following cases: * single edentulousness, * intercalary edentulousness, * terminal edentulousness, * total edentulousness. the following clinical conditions must be observed before placing a dental implant: * sufficient quality and volume of bone support; * healthy oral condition; * no contraindications for implant setting the expected benefits of this surgery are to improve the quality of life of patients, to recover the chewing function and the aesthetics of the smile.

Eligibility criteria:
inclusion criteria: * patient 18 years of age or older * patient who has completed bone growth * patient informed and willing to participate in the study * partially or totally toothless patient who will be implanted with the tbr® bone level implant(s) for the prospective cohort * patient implanted with the tbr® bone level implant(s) before june 2011 for the retrospective cohort exclusion criteria: * pregnant or lactating women * patient with bone disease of the head and neck region * patient refusing to participate in the study * patient with at least one contraindication to implantation * patient on osteoporosis treatment with biphosphonates or denosumab.
testing radical prostatectomy in chinese men with prostate cancer and oligometastases to the bone

Conditions: Prostate Cancer Metastatic

Summary: this study is to examine whether radical prostatectomy can impact survival and quality-of-life in men with oligo-metastatic prostate cancer.

in this study, patients with oligo-metastatic prostate cancer will be randomized to radical prostatectomy plus standard care and standard care only. standard care refers to androgen deprivation therapy (adt) +/- other systemic therapies. time to disease progression and post-treatment quality of life will be assessed and compared.

Eligibility criteria:
inclusion criteria: * participants is willing and able to give informed consent for participation in the study * male aged 19-75 years. * diagnosed with oligo-metastatic prostate cancer (1-3 skeletal lesions on bone specific imaging, no visceral metastases). * locally resectable tumor (clinical/radiological stage t1-t3). * eastern cooperative oncology group (ecog) performance status 0-1. * suitable for radical prostatectomy within 12 months of starting standard care. exclusion criteria: * contraindications to radical prostatectomy. * visceral metastases. * prior radiotherapy to the abdomen/pelvis or to skeletal metastases. * any systemic therapy of prostate cancer (including standard care) for 12 or more months prior to enrollment. * current involvement in other interventional research.

Keywords: oligometastasis prostate cancer radical prostatectomy progression-free survival quality of life
effect of a vegan diet versus a mediterranean diet. assessing health outcomes

Conditions: Cardiometabolic Syndrome

Summary: this study aimed to evaluate the effect of a vegan diet (supplemented with vitamin b12) and an mediterranean diet on performance, cardiorespiratory fitness, metabolic health, immune status, and environmental impact in healthy adults.

omniveg is a controlled crossover trial. initially, registered dietitians conducted an assessment of participants' lifestyles in a preliminary session. qualified nutritionists then developed personalized diets for each participant in accordance with the recommendations of the international society of sports nutrition (issn). these diets followed specific guidelines, including a daily intake of 3-5 g of carbohydrates per kilogram of body weight, 1.4-2.0 g of protein per kilogram of body weight, and 0.5-1.5 g of fat per kilogram of body weight. both the mediterranean diet and vegan diets prescribed to the participants were isocaloric, with similar distributions of macronutrients. the primary difference between the two interventions was the source of food: the vegan diet exclusively comprised plant-based foods, while the omnivorous diet included foods of both animal and plant sources. in the case of the omnivorous diet, 60% of the total protein intake was derived from animal sources (mainly from fish, white meat, low-fat dairy and eggs). as part of the vegan diet, participants were instructed to take 1000 µg of cyanocobalamin (a form of vitamin b12) twice a week from harrison sport nutrition, granada, spain. this supplementation aimed to ensure adequate vitamin b12 intake, which is essential for individuals following a vegan diet. throughout the study period, participants were advised to maintain their initial physical exercise frequency and volume to maintain consistency and avoid confounding variables. to ensure standardized measurements, all tests were conducted in the same laboratory, employing identical testing devices, and supervised by the same group of researchers. this approach aimed to minimize experimental variability and improve the reliability of the study's results.

Eligibility criteria:
inclusion criteria: * men. * aged between 18-40 years. * physically active according to the recommendations of the world health organization (who). * body mass index (bmi) between 18.5-24.9 kg/m2. * no tobacco use. * no or low alcohol consumption and no orthopedic limitations that would interfere with the performance of the study tests. exclusion criteria: * chronic diseases that impair athletic performance (cardiovascular, metabolic, gastrointestinal, respiratory) within the last six months. * musculoskeletal disease within the last six months.

Keywords: plant-based diet environmental impact cardiorespiratory fitness performance metabolic health mediterranean diet vegan diet
afo prescription to optimize post-stroke function

Conditions: Ankle Foot Orthosis (AFO); Stroke Patients; Post-Stroke Hemiparesis

Summary: the overall goal of this study is to attain the highest possible health-related quality of life for individuals with lower-limb impairment through a clinical trial examining three different modern carbon fiber ankle-foot orthosis (afo) treatment options targeting the rehabilitation of individuals post-stroke. to achieve this goal, the investigators will: 1. identify the factors that significantly contribute to an individual's highest potential quality of life when considering each of the three available afo design options, and 2. develop prediction models of clinical performance using biomechanical function linked to the three afo designs. participants will be asked to: * wear each of the three modern afo designs for one month, after receiving therapy training and * complete questionnaires and performance tests with each afo. in addition, the subset of individuals participating in goal 2) will also be asked to: * perform biomechanical analyses using high-speed cameras and force plates during different walking and balance tests with each afo design.


Eligibility criteria:
inclusion criteria: * be a minimum of three months post-stroke * be greater than 18 years of age * have been prescribed either a semi-rigid or a custom-made articulating afo * wear their prescribed afo for all primary mobility activity 7 days a week * be able to walk at least 20 meters without manual assistance * walk at least 10 meters per minute (12% of normal velocity) and no faster than 60 meters per minute (75% of normal velocity) during a 6-meter self-selected velocity walking test. exclusion criteria: * having a condition that could significantly limit ambulation, including severe osteoarthritis, rheumatoid arthritis, congestive heart failure, or pre-existing neurological disorder other than post-stroke * having one of the brace options be contraindicated for the patient * having cognitive deficits that preclude their ability to provide consent for participation * having an ankle plantar flexion contracture equal to or greater than 15 degrees plantar flexion with full knee extension * having marked inversion or ankle plantar flexor spasticity that interferes with foot placement for stance