Kornimate/medical-research-clean huggingface dataset:
the duration of spinal anaesthesia - a prospective, observational cohort study

Conditions: Orthopedic Disorder

Summary: today, surgery in an ambulatory setting is preferred for many reasons. total hip and knee arthroplasty (tha and tka) are now procedures where patients can be sent home on the same day of the surgical procedure. however, this requires substantial knowledge of factors affecting the length of hospital stay. in this prospective, observational cohort study, we will investigate factors that affect the duration of spinal anaesthesia which is often used in tha and tka. the aim is to gather enough data to be able to determine how local anaesthetic volume and dose affect the duration of spinal anaesthesia. this will enable us to decide whether spinal anaesthesia is a good option when performing tka and tha in an ambulatory setting.

with the increasing health care cost and the scarcity of nursing staff, there is considerable focus on providing surgery in an ambulatory setting. total hip and knee arthroplasty (tha and tka) are now procedures where selected patients are sent home on the same day after the procedure. therefore, knowledge of key factors affecting the length of stay is important. one factor is the method of anaesthesia used for the operative procedure. spinal anaesthesia is often used for tha and tka and has several advantages compared to general anaesthesia. however, spinal anaesthesia also has drawbacks, because it reduces the force in the legs, hindering early mobilisation. there are no good data on the duration of spinal anaesthesia. compared to the past, there has been a shift towards using lower doses of local anaesthetic (la) injected into the subarachnoid space. theoretically, this should result in a shorter duration of anaesthesia, and this would be of value in an ambulatory setting. however, if the variation in the duration is high and therefore not predictable for the individual patient, spinal anaesthesia has limitations in the ambulatory setting. the objective of the present study is to prospectively collect data on the type and dose of la injected into the subarachnoid space and the duration of spinal anaesthesia in participants scheduled for orthopaedic surgery in spinal anaesthesia. we hypothesise that the mean duration of spinal anaesthesia is positively correlated to the dose of la injected into the subarachnoid space.

Eligibility criteria:
inclusion criteria: * scheduled for elective orthopaedic surgical procedures performed in spinal anaesthesia, asa 1-4. exclusion criteria: age \< 18 years, anticoagulant medication therapy not paused according esaic/esra 2022 guidelines, local infection at the lumbar puncture site, bleeding disorder, unable to cooperate with the spinal anaesthesia procedure. -

Keywords: regional anaesthesia spinal anaesthesia
system accuracy evaluation of 6 ce-marked blood glucose monitoring system following iso 15197:2013

Conditions: Diabetes

Summary: the objective of this study is the evaluation of system accuracy following iso 15197:2013 (e), clause 6.3 in which accuracy requirements and applicable test procedures for blood glucose monitoring systems intended for self-monitoring of blood glucose by patients are stipulated. in this study, system accuracy evaluation will be performed with ce-marked bgms (bgms = blood glucose monitoring system) common among insulin pump users - accu-chek aviva nano and accu-chek performa nano (roche diagnostics), freestyle lite (abbott diabetes care), onetouch verio iq (lifescan) contour next link 2.4 (bayer healthcare diabetes care) and accu-chek mobile with three different reagent system lots for each bgms. the study will be performed in 2 parts. each part will comprise testing of 3 bgms.


Eligibility criteria:
inclusion criteria: * male or female, with type 1 diabetes, type 2 diabetes or no diabetes * for provoked blood glucose excursions due to insulin dose adjustment: * male or female with type 1 diabetes or * type 2 diabetes and intensified insulin therapy or insulin pump therapy. * minimum age of 18 years * signed informed consent form * legally competent and capable to understand character, meaning and consequences of the study exclusion criteria: * pregnancy or lactation period * severe acute disease (at the study physician's discretion) * severe chronic disease with potential risk during the test procedures (at the study physician's discretion) * physical or mental constitution that compromises the subject's capability to participate in the study (at the study physician's discretion) * incapability of giving informed consent * \< 18 years * legally incompetent * accommodated in an institution (e.g. psychiatric clinic) * language barriers potentially compromising an adequate compliance with study procedures * dependent from investigator or sponsor * for provoked blood glucose excursions 50 - 80 mg/dl (concentration category 2): * coronary heart disease * condition after myocardial infarction * cerebral incidence * peripheral arterial occlusive disease * hypoglycemia unawareness
a mindfulness-based intervention to improve cpap

Conditions: Obstructive Sleep Apnea (Moderate to Severe); Obstructive Sleep Apnea

Summary: the main purpose of this study is to assess the effectiveness of a mindfulness-based intervention in improving cpap use compared to online peer support


Eligibility criteria:
inclusion criteria: * adolescent age (13-18 years) * confirmed diagnosis of moderate or severe osa * adolescent should have the capacity to consent themselves exclusion criteria: * known developmental delay such that they are not able to participate in the study; * neuromuscular disorders * central sleep apnea * known diagnosis of severe psychiatric illnesses (e.g. suicidal ideation) * limited knowledge and proficiency in english to complete the study as judged by the clinical team
cognitive recovery between intubated and non-intubated thoracic surgery

Conditions: Cognition

Summary: in this randomized controlled trial, we aim to investigate whether the avoidance of mechanical ventilation by application of nonintubated thoracoscopic surgery improves intraoperative cerebral oxygenation and postoperative cognition recovery for patients undergoing thoracic surgery.

postoperative neurocognitive impairment is not uncommon for patients undergoing thoracic surgery. based on the literature, this is associated with reduced cerebral oxygenation during one-lung ventilation which may be because of reduced cardiac output, impeded cerebral venous return due to mechanical ventilation. in our hospital, nonintubated thoracoscopic surgery is commonly conducted and achieves noninferior outcomes than intubated thoracoscopic surgery. particularly, the application of nasal high flow oxygen may maintain intraoperative oxygenation despite the absence of controlled ventilation. therefore, the nonintubated technique may be beneficial to maintain an improved intraoperative cerebral oxygenation and hopefully improves postoperative cognition recovery. in this randomized controlled study, we aim to investigate the differences in intraoperative cerebral oxygenation and postoperative cognitive recovery bewteen nonintubated and intubated thoracoscopic surgery. patient will be randomly assigned to receive nonintubated or intubated thoracoscopic surgery. during surgery, bifrontal cerebral oxygenation will be monitored. cognitive test will be arranged before and after surgery.

Eligibility criteria:
inclusion criteria: adult patients receive elective thoracoscopic surgery exclusion criteria: 1. pregnancy 2. preexisting cerebral dysfunction such as cerebral vascular incidence, alzheimer's disease. parkinsonism. 3. cardiopulmonary dysfunction such as heart failure \> new york heart association score iii; chronic obstructive pulmonary disease with a forced expiratory volume in one second/forced vital capacity \< 70 % and fev1 \< 50% predicted.

Keywords: postoperative cognition nonintubated thoracic surgery
a study of eribulin mesylate with trastuzumab for advanced or recurrent human epidermal growth factor receptor 2-positive (her2+) breast cancer

Conditions: Breast Cancer

Summary: the purpose of the study is to evaluate dose limiting toxicity (dlt), investigate the tolerability and safety of eribulin mesylate with trastuzumab combination therapy, and estimate the recommended dose.


Eligibility criteria:
inclusion criteria * females aged greater than or equal to 20 years and less than 75 years at the time of informed consent. * histologically or cytologically confirmed with breast cancer * score 3+ by immunohistochemistry (ihc) or her2 positive by fluorescence in situ hybridization (fish) method * subjects who meet any of the following criteria: * evidence of recurrence during adjuvant chemotherapy with trastuzumab and taxane * evidence of recurrence within 6 months after adjuvant chemotherapy with trastuzumab and taxane * experienced prior chemotherapy including trastuzumab and taxane for advanced or recurrent breast cancer * adequate organ function * eastern cooperative oncology group (ecog)-performance status (ps) is 0 or 1 * subjects who have submitted written informed consent for study entry exclusion criteria * subjects with known brain metastasis accompanied by clinical symptoms or requiring active treatment * subjects with severe active infection requiring active treatment * subjects with large pleural effusions, ascites, or pericardial effusions requiring drainage. * hypersensitivity to trastuzumab, halicondrin b or halicondrin b chemical derivatives * known positive for human immunodeficiency virus (hiv) test or positive for hepatitis b surface (hbs antigen) or hepatitis c (hcv) by serum test. * subjects who are pregnant (positive b-hcg test) or breastfeeding * subjects judged to be ineligible for this study by the principal investigator or sub-investigator.

Keywords: breast cancer
low versus high peep in noninvasive ventilation for hypoxemic respiratory failure

Conditions: Noninvasive Ventilation

Summary: current study aimed to explore the effect of high peep during noninvasive ventilation among hypoxemic patients with acute respiratory failure.

this was a 1:1 randomized control trial to explore the effect of high versus low peep in noninvasive ventilation hypoxemic patients with acute respiratory failure. several icus in china performed this study. in the high peep group, the peep maintained at 10-15 cmh2o, the inspiratory pressure maintained at 15-20 cmh2o. in the low peep group, the peep maintained at 5 cmh2o, the inspiratory pressure maintained at 10-20 cmh2o. the primary outcome was incidence of noninvasive ventilation failrue.

Eligibility criteria:
inclusion criteria * age between 16 and 85 years * use of dedicated noninvasive ventilator * paco2 ≤50 mmhg * pao2/fio2 ≤300mmhg * expectation of noninvasive ventilation \>12 hours * consciousness (kelly score ≤3 or gcs≥13) exclusion criteria * use of noninvasive ventilation before randomization \> 24 hours * use of noninvasive ventilation due to heart failure, asthma, acute excerbation of copd * presence of contraindication of noninvasive ventilation such as malformation, rencent pulmonary or esophageal surgery et al. * end stage disease (expectation of life \< 6 months) * pneumothorax * noninvasive ventilation intolerance * refusal of paticipation * pregant woman * requirement of emergency intubation
the effect of acute concurrent exercise on inhibitory control: an event-related potential study

Conditions: Exercise; Cognition

Summary: the present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. the main questions it aims to answer are: (1) does acute concurrent exercise improve inhibitory control via behavioral and event-related potential approaches? (2) does lactate play a potential mediational role in the effect of acute concurrent exercise on inhibitory control?

the present study aimed to determine the effects of acute concurrent exercise (ce) on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate. participants were randomly assigned to either a ce, aerobic exercise (ae), or control (con) group. participants in the ce group engaged in 12-minutes of ae (40%-59% of heart rate reserve \[hrr\]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). the ae group participated in 25 minutes of ae (40%-59% hrr). prior to and following exercise onset, participants in both the ce and ae groups completed a 5-minute warm-up and cool-down. participants in the con group read books for 35 minutes. lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. response time (rt) and accuracy in the stroop test, as well as p3 amplitudes, were assessed before and after the treatment.

Eligibility criteria:
inclusion criteria: * aged between 20 and 30 years * able to exercise without undue risk (i.e., the first seven questions of the physical activity readiness questionnaire for everyone \[par-q+\] were answered "no") * right-handed dominance * typical or corrected-to-typical eyesight * limited physical activity in the previous month (i.e., \< 150 minutes/week of moderate-intensity physical activity) exclusion criteria: * psychiatric or neurological ailments * cardiorespiratory or neuromuscular conditions * obese status (body mass index \[bmi\] \> 27 kg/m2)
right ventricle dysfunction in critically ill patients

Conditions: Right Ventricular Dysfunction

Summary: to assess prevalence of right ventricle dysfunction in critically ill patient. to assess impact of rv dysfunction on short term (icu stay, hospital stay, or mortality ≤30 days) and long term outcome (\>30 days). to assess the accuracy of different parameters of rv dysfunction.

1. inclusion criteria: - adult patients who admitted to critical care of internal medicine department after obtaining consent during the period between august 2023 and august 2024. 2. exclusion criteria: 1. children below 18 yr. 2. patients who could not be scanned within 48h after icu admission. 3. sample size calculation: 200 patients 2.4.4 study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ): beside history and clinical examination , the following data will be obtained: demographic and historical data: the patient age, sex, history of hypertension, chronic obstructive pulmonary disease, ihd, cause of critical care unit admission and indication of mechanical ventilation( peep). clinical examination data: pulse, blood pressure, respiratory rate, temperature , bmi, and thorough chest, cardiac examination data will be obtained. volume state of the patient: cvp measurement, input and output fluid chart. apache iv score, use of vasopressors, use of sedatives. investigation : arterial blood gas analysis, pulse oxygen saturation, cbc, and renal function test and electrolytes, serum lactate and troponin. 12 lead ecg for rv strain patterns.

Eligibility criteria:
inclusion criteria: * adult patients who admitted to critical care of internal medicine department after obtaining consent during the period between august 2023 and august 2024. exclusion criteria: 1. children below 18 yr. 2. patients who could not be scanned within 48h after icu admission.
abstinence-linked money management multisite

Conditions: Dual Diagnosis; Cocaine Abuse; Cocaine Dependence; Polysubstance Abuse

Summary: randomized clinical trial comparing a money management-based intervention involving storage and management of client funds, substance abuse counseling, and risk reduction counseling to individualized drug counseling.


Eligibility criteria:
inclusion criteria: * enrolled in ambulatory psychiatric treatment at one of the participating clinics * receives ssi or ssdi payments * able to provide written informed consent * cocaine use within the last 60 days as evidenced by either a positive toxicology screen or self-reports exclusion criteria: * has a conservator of person * a history of violence towards clinical providers or predatory violence * suicidal plans or intent; homicidal plans or intent. suicidal or homicidal ideation will not be exclusion criteria * physiological dependence on alcohol, illicit opiates or illicit sedatives as evidenced by a history of four weeks of daily use of these substances; and either tolerance or withdrawal (as defined by dsm iv-tr). the "standard withdrawal scales" referred to in dsm iv-tr will be the ciwa-ar (sullivan et al., 1989) and the clinical opiate withdrawal scale (wesson and ling, 2003), with p.i. review because signs on the ciwa-ar such as "aware of sounds around you" may reflect psychiatric illness, not withdrawal * will not be able to complete the twelve months of the study because of anticipated incarceration or move * had been enrolled in the ongoing study * unable to speak and understand english

Keywords: disability substance abuse cocaine abuse dual diagnosis representative payee hiv risk reduction
community influences transitions in youth health (city) health ii - center for the study of community health

Conditions: Sexually Transmitted Diseases; HIV Infections

Summary: the purpose of this protocol is to develop and evaluate an hiv prevention entertainment education (ee) intervention aimed at reaching underserved, at-risk african americans, aged 18-25 years, living in disadvantaged urban neighborhoods in the birmingham area.

the goal of this 5 year project is to promote hiv testing and improve hiv-related risk behaviors (e.g. condom use, substance use before sex, regular sexually transmitted infection (sti) testing) via population-sensitive and population-specific hiv prevention videos that are appealing, evidence-based, scalable, and sustainable to the target population. formative research was conducted in phase i (year 1-2), to pre-test the questionnaire and gather in-depth data (via focus groups, intercept interviews, and individual structured interviews) to inform intervention development. phase 2 of the project involved developing, delivering, and subsequently evaluating the efficacy of peer-driven ee hiv prevention messaging to broader social networks via a social media platform, with the platform contingent on formative data. an hiv education video series, "the beat hive", was produced and served as intervention materials for the quasi-experimental research project. respondent driven sampling (rds) was used to access and use the social networks of high-risk youths as channel and agents for change. rds is a recent innovative adaptation of chain-referral network sampling that provides peer-driven access to hard-to-reach subpopulations while reducing sampling biases associated with conventional snowball sampling.

Eligibility criteria:
inclusion criteria: african american young adults aged 18-25 living in the birmingham usa competent to give informed consent exclusion criteria: obvious psychosis, dementia, inability to hear. plan to move within the next 6 months

Keywords: prevention and control young adults african americans education entertainment condom use
efficacy of a chemically activated composite resin alkasite in atypical caries lesions of deciduous teeth

Conditions: Dental Caries in Children

Summary: atypical cavities, which involve more than two surfaces being one of them vestibular or lingual/palatine, are a challenge for restorative dentistry, since the risk of failure of the restorations are related to the number of surfaces involved. thus, the objective of this project is to conduct a randomized clinical trial in order to evaluate the efficacy and patient-centered outcomes of a chemically-activated alkasite composite resin in atypical lesions of deciduous molars. deciduous molars of children between 4 and 7 years of age with at least one atypical cavity lesion in deciduous molars will be selected for the ecr. the selected teeth will be randomly divided into two groups: chemically activated composite resin alkasite and resin-modified glass ionomer cement. clinical and radiographic follow-up of the lesions will be performed for 6 and 12 months. the efficacy of the treatments will be evaluated by the longevity of the restoring procedures and the arrestment of the caries lesions. patient-centered outcomes will also be evaluated.


Eligibility criteria:
inclusion criteria: • children will be included who have at least one posterior tooth with atypical caries lesion. exclusion criteria: * patients with special needs * patients general health conditions that may affect the oral cavity * patients non-cooperating in relation to the examination * patients with orthodontic apparatus * the parents/guardians or children not to consent to their participation in the study. * teeth with pulp exposure * teeth with spontaneous pain * teeth with mobility * teeth with presence of swelling or fistula close to the tooth * teeth with furcation or cervical injury * teeth with restorations, sealants or enamel formation defects will be excluded.

Keywords: dental caries deciduous teeth permanent dental restoration
an adult spasticity registry of onabotulinumtoxina treatment

Conditions: Muscle Spasticity

Summary: this is a registry study in adults with spasticity to determine onabotulinumtoxina use in clinical practice. treatment will be administered in accordance with physician standard practice. all treatment decisions lie with the physician.


Eligibility criteria:
inclusion criteria: * treatment with onabotulinumtoxina according to the decision of the physician for spasticity * willingness to complete study questionnaires and answer study questions by phone or internet exclusion criteria: * concurrent participation in a clinical trial for spasticity