Kornimate/medical-research-clean huggingface dataset:
screening of dysphagia via ultrasonography in patients with stroke

Conditions: Dysphagia, Oropharyngeal; Stroke

Summary: oropharyngeal dysphagia is commonly seen in patients with stroke. clinical assessment may be used to evaluate dysphagia in patients with stroke however reliability of this method is controversial and videofluoroscopic study is still considered as gold standard. however, exposure to radiation, necessity for a experienced practitioner, an expensive device, and swallowing contrast agents are disadvantages of videofluoroscopy. ultrasonography, on the other hand, is a cheap, noninvasive device which may demonstrate tongue and laryngeal movement dynamically. in this manner, this study aims to evaluate whether ultrasound can assess dysphagia in patients with hemiplegia accurately.

for a safe swallowing tongue muscles must function properly and larynx should replace superoanterior to close trachea via stretching cricopharyngeal muscle. in this context, approximation of thyroid cartilage and larynx is important for swallowing. these mechanisms are impaired in stroke, parkinson's disease, traumatic brain injury, and neuromuscular disorders thus resulting oropharyngeal dysphagia. clinical examination may be used for assessing dysphagia in those patients however reliability of this method is controversial and videofluoroscopic study is considered as gold standard for assessing dysphagia. ultrasound is used to assess swallowing functions since 1970s however, the studies commonly focused on tongue thickness and functions. due to advances in technology besides tongue thickness, ultrasonography may practically demonstrate how larynx and thyroid cartilage approximate and hor larynx moves anteriorly. in literature, three methods came to forefront as evaluation methods for dysphagia: 1) approximation of thyroid cartilage and hyoid bone (tha), 2) tongue thickness in rest (tt), and 3) hyoid bone anterior replacement (har). in previous studies, the efficiency of tha for assessing dysphagia via videofluoroscopic study has been demonstrated. however other methods have not been evaluated in dysphagic patients with stroke. ultrasonography, as a cheap, portable and non-invasive method, is a promising for assessing dysphagia in patients with stroke. in this context, this study aims to test the reliability and efficacy of these three methods via ultrasound in dysphagic stroke patients and test the performance of ultrasound compared to videofluoroscopy.

Eligibility criteria:
inclusion criteria: * stroke diagnosis * aged 18-75 * dysphagia assessed by bedside examination (phase 1: wet voice or cough after drinking 5 ml clear water is positive, phase 2: if phase 1 is negative, inability of drinking 60 ml of water in 2 minutes without coughing or wet voice is positive) exclusion criteria: * unable to consent due cognitive dysfunction * unable to cooperate with videofluoroscopic study * dysphagia before stroke * rheumatologic or neuromuscular disorder that may cause dysphagia

Keywords: hemiplegia dysphagia ultrasound videofluoroscopy
effects of exercise training on fatigue in thyroid cancer survivors

Conditions: Thyroid Cancer

Summary: researchers are trying to determine whether an exercise program reduces fatigue and improves physical activity in thyroid cancer patients.


Eligibility criteria:
inclusion criteria: * adults ≥18yrs of age with well-differentiated thyroid cancer and self-reported fatigue any time after initial treatment of thyroid cancer. * english speaking * able to provide consent exclusion criteria: * pregnant * medullary thyroid cancer * anaplastic thyroid cancer * physical limitations to perform exercise
the reality study - head-to-head comparison between cypher and taxus

Conditions: Coronary Artery Disease

Summary: the main objective of this study is to compare the performance of the cypher sirolimus-eluting and the taxus paclitaxel-eluting stent systems in a prospective, multi-center, randomized clinical study.

this is a prospective, randomized study conducted at 90 centers in europe, latin-america and asia. a total of 1335 patients will be entered into the study and will be randomized on a 1:1 basis to either the sirolimus-eluting or the paclitaxel-eluting stent system. all patients will have repeat angiography at eight months and will be followed for 24 months post-procedure.

Eligibility criteria:
inclusion criteria: 1. diagnosis of angina pectoris as defined by canadian cardiovascular society classification (ccs i, ii, iii, iv) or unstable angina pectoris (braunwald classification b\&c, i-ii-iii) or patients with documented silent ischemia; 2. treatment of up to two de novo native coronary artery lesions in a maximum of two major coronary arteries; 3. ostial lesions; 4. bifurcations; 5. target vessel diameter of both lesions must be \>=2.25mm and \<=3.0mm in diameter (visual estimate); 6. one target lesion must be at least 15 mm in length and the second lesion has to be at least 10 mm in length with no upper limit on either; 7. target lesion stenosis for both lesions is \>50% and \<100% (visual estimate). exclusion criteria: 1. patient has experienced a q-wave or non-q-wave myocardial infarction with documented total ck \>2 times normal within the preceding 72 hours and the ck and ck-mb enzymes remain above normal at the time of treatment; 2. has unstable angina classified as braunwald a i-ii-iii; 3. any of the lesions is an unprotected left main coronary disease with \>=50% stenosis; 4. angiographic evidence of thrombus within target lesion; 5. heavily calcified lesion and/or calcified lesion, which cannot be successfully predilated (applies to both lesions); 6. documented left ventricular ejection fraction \<=25%; 8. totally occluded vessel (timi 0 level) (applies to both lesions); 9. prior stent within 10mm of target lesion (applies to both lesions).
the effect of changing angle of bed on pain severity and vascular complications among cardiac catheterization patients

Conditions: Cardiac Catheterization

Summary: care of cvd patients in egypt is very complex and sensitive because of the high incidence and high mortality rate. in 2019, approximately 18.6 million deaths were attributed to cvd globally. as a consequence, cardiac catheterization remains the criterion standard for evaluation of cad.

this study will be conducted in three phases; preparation, implementation, and evaluation. 1. preparation phase * ethical approval will be obtained from the research ethics committee (rec) of the faculty of nursing - mansoura university. * content validity of the developed tool will be reviewed by a jury of five experts in the study field and the suggestions of the jury members will be considered. * the reliability of this tool will be assessed also by using cronbach's alpha test. 2. implementation phase * an initial assessment will be carried out for all patients to confirm that they are free from the exclusion criteria. * patients will be assigned into two groups: intervention group and control group, 41 patients for each group. * before the cardiac catheterization procedure: patients' demographic characteristics and health relevant data will be collected on the first day of admission using part i and part ii of tool i. * in both groups after cardiac catheterization procedure: the sheath will be removed immediately by the nurse. * in the control group: positioning the patients in supine for 6 hours and the affected leg was straight and immobilized. * in the intervention group: the researcher will change angle of bed from 15° to 45°. * the severity of pain will be assessed by using part iii of tool i for five times starting immediately after sheath removal. * vascular complications monitoring scales will be assessed by using tool iii for five times starting immediately after sheath removal. 3. evaluation phase this phase aims to investigate the effect of changing angle of bed on pain severity and vascular complications for both groups.

Eligibility criteria:
inclusion criteria: adult patient ≥ 18 years old of both sexes. * conscious patients admitted to the ccu after diagnostic or therapeutic cardiac catheterization. * patients who will have femoral artery catheterization. * patients who will have normal prothrombin time and partial thromboplastin time. exclusion criteria: * patients who have previous surgery in the iliac or femoral artery. * patients who have chronic back pain. * patients who have an active bleed¬ing, hematoma and ecchymosis from insertion site prior to the sheath withdrawal. * patient who take anti-coagulant drugs and analgesic therapy within the previous 24 hours before the procedure.
diagnostic value of hs-crp in stable angina.

Conditions: Stable Angina; Positive ETT

Summary: the aim of this study was to assess the amount of additive value of hs-crp levels to a positive exercise tolerance test (ett) in predicting coronary artery disease (cad) using coronary angiography as the gold standard. the investigators concluded that hs-crp can be used as a single predictor of coronary vessel involvement in patients with stable angina and positive ett.

the investigators included 97 patients with positive ett and stable angina and saw that hs-crp is the only predictor of severity of cad as compared with coronary angiography in stable angina patients.

Eligibility criteria:
inclusion criteria: * stable angina * positive ett exclusion criteria: * unability to perform ett * contraindications for ett and angiography study

Keywords: exercise tolerance test hs-crp coronary angiography patients
a reader study to assess accuracy and reliability of flortaucipir f 18 positron emission tomography (pet) scan interpretation

Conditions: Alzheimer Disease

Summary: this study will evaluate the performance of physician readers trained to read flortaucipir-pet (positron emission tomography) scans.


Eligibility criteria:
scan reader criteria (5 total): * board-certified in radiology or nuclear medicine * professional experience interpreting pet scans * naive to study protocol * no previous training or exposure to avid flortaucipir f 18 read methodology scan criteria: - previous enrollment in study a05 confirmatory cohort (nct02016560), or a16 (nct02516046) scan study population criteria for fr01 (a05 confirmatory cohort): * cognitively-impaired * mild cognitive impairment (mci) or dementia with suspected neurodegenerative cause * mini-mental status exam (mmse) score of 20-27, inclusive scan study population criteria for fr01 (study a16): * subjects at end of life (less than or equal to 6 months) * imaged with flortaucipir f18 and came to autopsy

Keywords: flortaucipir f 18 positron emission tomography 18f-av-1451 diagnostic imaging tau imaging
virtual reality mindfulness in preoperative anxious patients

Conditions: Test Anxiety; Anxiety State; Preoperative Period

Summary: the goal of this interventional study is to reduce preoperative anxiety by virtual reality mindfulness. population: all adults, able to give their consent and scheduled for surgery with high preoperative anxiety defined by amsterdam preoperative anxiety and information scale (apais) score \> 10. the study will recruit 100 patients in one university teaching hospital. the main question it aims to answer is: may mindfulness by virtual reality reduce preoperative anxiety in patients particularly anxious for the surgery? participants will be asked to undergo to a single mindfulness virtual reality session before the surgery.


Eligibility criteria:
inclusion criteria: * adults able to give their consent, scheduled for elective surgery and with high preoperative anxiety defined by amsterdam preoperative anxiety and information scale (apais) \> 10 exclusion criteria: * pregnancy * epilepsy * pacemaker wearers * mental diseases * alcohol or drug addiction * severe hearing loss or blindness * simultaneous participation to other studies
hpv infections in older women

Conditions: Papillomavirus Infections

Summary: the purpose of this study is to determine risk factors for hpv infections in 25 to 65 year old women who report having used internet dating websites in the past year.

whether older women are susceptible to acquiring new, persistent high-risk (hr) hpv infections from new sex partners is largely unknown. this is a longitudinal study of predictors of hr hpv infections in two populations of women aged 25 to 44 and 45 to 65 who have used internet dating websites in the past year. 300 women will be recruited and mailed kits for self-collecting vaginal specimens for hpv dna testing. women will self-collect four sets of vaginal specimens four months apart, and complete sexual behavior questionnaires at the time of each self-collection. we will identify behavioral and health predictors of type-specific hr hpv infections, predictors of repeatedly-detected hr hpv infections, and evaluate study participants' experiences with self-collecting vaginal specimens and attitudes towards hpv vaccination and cervical cancer screening. this information is important for developing guidelines for hpv vaccine implementation and cervical cancer screening guidelines in populations of older women.

Eligibility criteria:
inclusion criteria: * have had sex with men * have used the internet to search for romantic partners in the past year (e.g. posted or responded to an ad on an internet dating website or social networking website) exclusion criteria: * pregnant, breastfeeding, or planning a pregnancy in the next 6 months * hysterectomy
identification of factors associated with the occurrence of severe forms of covid-19 infection in patients with inflammatory rheumatism or autoimmune diseases

Conditions: SARS-CoV2 Infection; Rare Diseases; Chronic Inflammatory Rheumatism; Autoimmune Diseases

Summary: factors associated with severe forms of covid-19 infection in patients with inflammatory rheumatic diseases (ird) or autoimmune diseases (aid) are unknown. this unprecedented situation leads to empirical and potentially erroneous advice and recommendations for care. identifying factors associated with severity, in the context of this pandemic, which is expected to last many months, and possibly years, is crucial for future patients. the objective of this work is to identify the factors associated with the occurrence of severe forms of covid-19 infection in patients with ird or aid, by combining analysis of 2 large databases.


Eligibility criteria:
inclusion criteria: * patients with known chronic inflammatory rheumatism, auto-immune or auto-inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis lupus, sjögren's syndrome, inflammatory myositis, systemic vasculitis, sarcoidosis, scleroderma, ppr/horton's, other ...) * at least 18 years old * sars-cov-2 infection (covid-19) by biological data (serological or positive cov-2 pcr) or ct scan images or clinical observations consistent with covid-19 between january 2020 and september 2020 * data available in the aphp health data center (eds) or in the french rmd covid19 cohort exclusion criteria: * patients opposed to the use of their data

Keywords: sars-cov2 infection rare diseases chronic inflammatory rheumatism autoimmune diseases auto-inflammatory diseases
intrathecal magnesium and postoperative analgesia

Conditions: Total Hip Replacement

Summary: magnesium is implicated in the activation of nmda receptors by amino-excitatory acids in the central nervous system \[1\]. magnesium deficiency is associated to an increased activation of these receptors, and to an increased sensitivity to pain in animals. spinal cord is the site of sensitization of pain, mainly mediated by the nmda receptors, and intrathecal magnesium may have anti-hyperalgesic effect when administered intrathecally \[2\]. as intrathecal magnesium has already been used in humans for treatment of eclampsia, we stated that it could also improve postoperative analgesia and reduce the need for auto-administered morphine if given (50 mg of magnesium sulfate) with the intrathecal anesthetic drugs (bupivacaine and sufentanil) injected for orthopedic surgery.

magnesium is implicated in the activation of nmda receptors by amino-excitatory acids in the central nervous system \[1\]. magnesium deficiency is associated to an increased activation of these receptors, and to an increased sensitivity to pain in animals. spinal cord is the site of sensitization of pain, mainly mediated by the nmda receptors, and intrathecal magnesium may have anti-hyperalgesic effect when administered intrathecally \[2\]. as intrathecal magnesium has already been used in humans for treatment of eclampsia, we stated that it could also improve postoperative analgesia and reduce the need for auto-administered morphine if given (50 mg of magnesium sulfate) with the intrathecal anesthetic drugs (bupivacaine and sufentanil) injected for orthopedic surgery.

Eligibility criteria:
inclusion criteria: * total hip replacement under intrathecal anesthesia. exclusion criteria: * general anesthesia (alone or not) * intolerance to morphine * misunderstanding of the use of the device for intravenous patient-controlled administration of morphine.

Keywords: magnesium pain morphine intrathecal nmda elective total hip replacement under intrathecal anesthesia
biological aging of skeletal muscles in humans

Conditions: HEALTHY

Summary: aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. the progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more. however, strong inter-individual variations of this prevalence of sarcopenia exists. the key issue is to understand why the biological aging of the skeletal muscle is so different between people. in this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.

aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. the progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more. however, strong inter-individual variations of this prevalence of sarcopenia exists. some elderly (60 years old) reveal a biological aging of 80 years old, whereas 60 years old people reveal a biological aging of 60 years old. the key issue is to understand why the biological aging of the skeletal muscle is so different between people. previous sarcopenia studies in humans did not really focus on chronological aging, they were all based on a comparison between young and old people. no study considered inter-individual modifications (biological aging) in sarcopenia. furthermore, few studies were associated in the same study to "omic", histological, and epigenetic data, to obtain integrated point of view of human sarcopenia. in this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.

Eligibility criteria:
inclusion criteria: * belonging to the proof cohort * between 80 and 83 years old * informed consent signed * genetic analyses consent signed * subject affiliated or entitled to a social security scheme exclusion criteria: * anti coagulative treatment * severe obesity (\>35) * all chronic pathology requiring a treatment * severe renal insufficiency (discovery less than 6 months) * abnormal coagulation appraisal * allergy to local anesthetics * installation of a prosthetic hip and / or knee in the last six months * senile dementia * refusal of genetic study

Keywords: sarcopenia elderly muscle biopsy
the effects of entrainment on respiratory stability and cerebral oxygenation in preterm infants

Conditions: Prematurity

Summary: infants born prematurely at will be asked to participate in this randomized controlled trial at a corrected gestational age of 24-37 weeks. infants will be randomly selected to each of the two groups: intervention and control. infants in the treatment group will receive six intervention days over a two-week period, 3 sessions per week. each intervention day consists of each of the two interventions in a random sequence: no intervention/silence and live ocean disc instrument intervention. the sound decibel level will also be recorded and maintained at 40-65db to prevent overstimulation. each infant will thus receive control and ocean disc intervention on the same day in the nicu. interventions will be given in a randomized order (i.e., first ocean disc or first silence, randomized to am or pm), with observation occurring for 10 minutes before each intervention, 15 minutes during each intervention, and 10 minutes after each per session. there will be 3 sessions per week for a two-week randomized treatment schedule. for each infant, data on total apnea time, mean respiratory rate, heart rate, o2 levels and behavior rating during will be collected. the sound decibel level will also be recorded and maintained at 40-65db to prevent overstimulation and hearing damage. near-infrared light spectroscopy (nirs) data on cerebral oxygenation will also be collected. observations will be recorded on the infant's activity or when change occurs, such as a pacifier falling out. parents and nurses will be asked to behave as they normally would during routine care.


Eligibility criteria:
inclusion criteria: * newborns born at 24-37 weeks' gestation at mount sinai hospital * newborn is considered appropriate for clinically indicated music therapy exclusion criteria: * infant not expected to survive 24 hours from the time of study entry (to be assessed by a member of the nicu faculty other than the pi) * infant of uncertain viability (gestation \<23 weeks, birth weight \<500 grams) * known or suspected genetic disorder (e.g., trisomy 21) * identified hearing disorder

Keywords: music therapy ocean disc prematurity vital signs cerebral oxygenation
incorporating healthy living strategies to aid in recovery after acute pulmonary embolism

Conditions: Acute Pulmonary Embolism

Summary: the purpose of the erase-pe study is to determine whether two different healthy living strategies (along with anticoagulation) might aid in recovery after a patient is hospitalized for pulmonary embolism. specifically, investigators will compare changes in cardiac effort (#heart beats used during the 6-minute walk test/walk distance) measured after an 8-week program.


Eligibility criteria:
inclusion criteria: 1. english speaking (\>18 years old). daily messages will be sent in english. 2. acute pe with at least one of the following: 1. any right ventricular enlargement or dysfunction on echocardiogram; 2. ct angiogram reporting any right ventricular enlargement; or 3. elevated cardiac biomarker (nt-pro bnp or troponin above baseline). criteria for enrollment will be included on source document. 3. rate controlled atrial arrythmias (resting heart rate \<110 beats/m) are eligible for enrollment. this includes atrial fibrillations. this is standard of care management for atrial fibrillation. 4. subjects do need to take prescribed anticoagulation. exclusion criteria: 1. pregnancy. 2. cardiac effort \>3.5 beats/m during 6mwt. 3. resting tachycardia \>110 beats/m at hospital discharge. 4. chronic thromboembolic pulmonary hypertension 5. systolic blood pressure \>180 mmhg at hospital discharge. 6. inability to walk. 7. estimated prognosis \<12 months at the time of discharge due to underlying co-morbidities (e.g., cancer). 8. advanced neurologic disease and would not be able to comply with the messages. 9. lack of access to email or text messaging 10. inability or unwillingness to follow daily instructions.

Keywords: recovery acute pulmonary embolism six minute walk cardiac effort actigraphy