Kornimate/medical-research-clean huggingface dataset:
3d shoulder kinematics during throwing-related movement patterns tasks in upper extremity low-to-moderate/moderate-to-high loading conditions

Conditions: Shoulder Pain

Summary: the main purpose of this study is to characterize and compare the 3d shoulder kinematics bilaterally while performing functional movement patterns tests that hypothetically replicate the 5 main phases of the throwing cycle. the tests are based on diagonal d2 for flexion (early and late cocking of the arm) and d2 for extension (acceleration, deceleration and follow-through of the arm) of the upper extremity of proprioceptive neuromuscular facilitation techniques.

the 3d shoulder kinematics (thorax, scapula and humerus) will be collected in different groups of subjects with specific characteristics. to load the upper extremity during pnf d2 for flexion and extension directions, elastic tubing (thera-band) will be used as resistance. selection of the two resistances will be according to a self-perceived ability of the subjects to consistently move a maximal amount of resistance (color) during pnf d2 flexion and extension tests for 15s and 30s, respectively. each subject will be permitted to sample various resistances in order to assist in selecting the most appropriate load, with no more than three practice repetitions permitted per each resistance sampled. to perform the tests, subjects will be sited in a standard chair without armrests, with their feet and lower legs placed on another standard chair, positioned just in front of their chair and the non-testing arm placed across the thoracic wall, to minimize the participation of the legs and trunk to upper extremity performance during testing. elastic tubing will be anchored to a stable base to perform the diagonals (thera-band door anchor accessory or the opposite foot). five repetitions of each test on both sides will be performed, in two different moments (5-10 minutes apart). a rate of 2 seconds per repetition will be employed during recordings using a metronome. a rest period will be given between trials to avoid fatigue. to perform the tests, subjects will begin/end with their hand on the contralateral hip and end/begin at head height and shoulder width. a marker will be placed in the latter position to standardize the start and end of hand position. the order of the tests (pnf d2 flexion and extension) and side (symptomatic/dominant and asymptomatic/non-dominant) will be randomized.

Eligibility criteria:
inclusion criteria: * subjects who can perform at least 150 degrees of arm elevation exclusion criteria: * subjects rating pain ≥8/10 * score 5 on any of the items of the disabilities of arm, shoulder and hand (dash) * pain elicited by provocation maneuvers of the neighboring regions (e.g., cervical spine).
interferon-alpha treatment of chronic cough in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Conditions: Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Cough

Summary: the purpose of this study is to determine whether lozenges containing interferon-alpha can reduce the frequency and severity of coughing in patients with chronic obstructive pulmonary disease (copd) and idiopathic pulmonary fibrosis (ipf).

both chronic obstructive pulmonary disease (copd) and idiopathic pulmonary fibrosis (ipf) frequently lead to a chronic cough that negatively impacts the quality of life (qol) for patients and those around them. this is a randomized, double-blind, placebo-controlled trial to determine whether interferon-alpha, delivered in low doses via orally dissolving lozenges given 3 times per day for 4 weeks, can reduce the frequency and severity of chronic cough in patients with copd or ipf. cough frequency will be assessed via 24-hour digital audio recordings made prior to entry, and at weeks 2 and 4 of treatment. cough severity will be assessed via a 100-mm visual analog scale questionnaire completed by the subject prior to entry and then weekly during treatment. subjects will also complete questionnaires regarding cough frequency, duration and intensity, qol, dyspnea, and antitussive medication usage weekly during treatment. all questionnaires will be repeated weekly during a 4-week post-treatment observation period to assess durability of response.

Eligibility criteria:
inclusion criteria: for all patients * history of clinically significant chronic cough for \> 3 months * for copd patients * \>40 years of age * 20-pack-year history of smoking * gold classification of stage 1 or higher * for ipf patients * \> 50 years of age * history of unexplained dyspnea on exertion of \> 3 months * exhibits coughing and bilateral, basilar, inspiratory crackles on physical exam * presents as being in a stable phase of ipf * lung biopsy or hrct indicative of ipf exclusion criteria: * ace inhibitor use * gerd * current cancer or history of lung cancer * non-ambulatory * hospitalized in the previous 12 months for heart failure

Keywords: chronic cough copd ipf interferon alpha
functional respiratory imaging of airways in ards

Conditions: ARDS, Human

Summary: this is a prospective single-center cohort trial to compare regional bronchial recruitment, bronchial distention and alveolar recruitment in 6 patients with acute respiratory distress syndrome (ards). the investigators used ct scan images as the imaging modality, and the subjects were scanned on end-expiratory lung volume with different positive end-expiratory pressures. those images were post-processed to evaluate the airways.


Eligibility criteria:
inclusion criteria: * mechanically ventilated * moderate or severe ards, as defined by the berlin criteria exclusion criteria: * pregnancy * hemodynamic instability * obesity (bmi \>30)
examination of the relationship between home affordances with development

Conditions: Preterm Birth

Summary: babies with a history of premature birth and low birth weight are at risk for developmental disorders. these infants may have motor, cognitive and behavioral problems compared to their term peers. although advances in technology lead to an increase in survival rate, 50% of these infants may have developmental delays in motor, cognitive and behavioral areas. premature birth does not accelerate any of the early sensory development processes, but exposure to intense, unusual stimuli of unusual character may delay or inhibit sensory development. therefore, children born prematurely may be at risk in terms of sensory processing. the physical, sensory and social environment of the infant and young child is critical in supporting the healthy and appropriate development of the brain and nerve-sensory systems.

a newborn baby reacts involuntarily or reflexively to its environment. during the first few years of life, through physical growth and learning experiences, the child learns to participate actively in the world. motor skills and sensory experiences begin to develop after birth, and development continues as children grow. having good motor control also helps children explore the world around them, which can help many other areas of development. there are many environmental and biological factors that affect motor development. especially the home environment where the child spends most of his time is one of the key factors affecting motor development. the home environment is known to be a very important factor for motor development in infants. at the same time, the variety of equipment and environmental conditions help children provide different sensory experiences. exploring the home environment can have important developmental implications, as it is common practice for physiotherapists to advise patients on home activities. environmental factors can affect the motor development of preterm children as well as other developmental areas. the number of studies examining the effects of environmental factors on motor and sensory development in preterm infants is limited in the literature. this study was planned to examine whether there is a relationship between the environmental conditions and equipment variety and the motor and sensory development of the preterm child.

Eligibility criteria:
inclusion criteria: fifty infants between 4-18 months with a history of premature birth and with the consent of their parents will be included in the study. exclusion criteria: babies with chromosomal anomaly, serious congenital problems and whose parents are not willing to work will not be included in the study.

Keywords: preterm home affordances sensory development motor development
evaluation of the impact of hospitalization in intensive care for covid-19 infection

Conditions: Covid19

Summary: to evaluate the psychological, physical, social, professional and family impact of a hospitalization in intensive care for a covid 19 by analysis of the verbatim during a semi-structured interview.


Eligibility criteria:
inclusion criteria: * all patients hospitalized in intensive care at ch dron for a covid 19 who have given their agreement during their follow-up consultation exclusion criteria: * minor patient * patient does not speak french * refusal to participate
functional changes of urogenital system after holmium laser prostatectomy

Conditions: Prostatic Hyperplasia

Summary: holmium laser prostatectomy will enhance voiding function. holmium laser prostatectomy will enhance sleep quality. holmium laser prostatectomy will enhance renal function. holmium laser prostatectomy will enhance erectile function. holmium laser prostatectomy will enhance the health-related quality of life.

check urodynamic parameters for voiding function evaluation check low urinary tract symptoms (ipss: international prostate symptom score) for voiding function evaluation check pittsburgh sleep quality index for sleep quality evaluation check estimated glomerular filtration rate and urine protein/creatinine ratio for renal function evaluation check international index of erectile function score (iief-5) for erectile function evaluation check nocturnal penile tumescence parameters for erectile function evaluation check 36-item short- form health survey (sf-36) for evaluation of the health-related quality of life.

Eligibility criteria:
inclusion criteria: * prostate size over 30 cc by transrectal ultrasonography * prostate-specific antigen level less than 10 ng/ml * international prostate symptom score more than 7 * at least one of followings: bladder outlet obstruction index \> 40, maximal flow rate \ 100cc or schäfer grade ii or more exclusion criteria: * patients who do not want surgery * evidence of prostate cancer or bladder cancer during evaluation or treatment * all of followings: bladder outlet obstruction index is less than 40, maximal flow rate is 10 or more cc/sec, postvoid residual urine is less than 100cc and schäfer grade ii or less * major depressive disorder, dementia, parkinson's disease, neurological deficits * history of pelvic radiation therapy * poorly controlled diabetes mellitus or hypertension

Keywords: prostatic hyperplasia
effectiveness of recombinant human growth hormone therapy for children with pms

Conditions: Phelan-McDermid Syndrome; Growth Hormone Treatment

Summary: in summary, this piot study with 6 participants shown that recombinant human growth hormone (rhgh) has a positive effect on the treatment with pms. in addition, this study indicated that rhgh can improve pms symptoms via increase the level of serum insulin-like growth factor-1 (igf-1) and insulin-like growth factor binding protein 3 (igfbp-3). rhgh may be low cost, more accessible, alternative treatment for pms.

compared with the placebo, rhgh treatment significantly decreased the total scores and subscale scores of gds (p \ 0.05). one participant developed skin allergy the day after the first rhgh treatment, which were resolved later.

Eligibility criteria:
inclusion criteria: * patients diagnosed with pms aged from 1years to 5 years exclusion criteria: - active or suspected tumour, intracranial hypertension, chronic kidney disease, acute proliferative or severe nonproliferative diabetic retinopathy, allergy to rhgh or severe comorbidity

Keywords: phelan-mcdermid syndrome growth hormone treatment cross-over placebo-controlled
water soluble vitamins and trace elements loss in hemodiafiltration patients

Conditions: Chronic Hemolysis

Summary: end stage renal disease is a severe pathology in which some toxic waste and an excessive amount of water can accumulate in the human body with life threatening consequences. maintenance hemodialysis is one of the possible treatment for this disease. hemodialysis filter the blood through a membrane according to a dialysis bath and so can be able to purify the blood of the toxic waste. otherwise, since the 1980s, the investigator know that patient in maintenance hemodialysis can have some deficiency in water soluble vitamins and trace elements. mechanisms of the deficiency are multiple (a decreased of food intake, a diminution of the appetite, digestive malabsorption du to medics and comorbidities and loss in hemodialysis). impact of this deficiency have an important impact on vital prognosis for these patients. these nutrients are essential for and synthesis, mechanism of inflammation, cells membranes synthesis, etc. dopps study in 2004 have shown a decreased of 16% in the mortality within 4 years with supplemented patients. also, since this study, international recommendations were wrote in 2009, then in 2020, in order to supplement in vitamins and trace elements patients in maintenance conventional hemodialysis. despite these recommendations, some supplementary efforts are necessary, especially since online hemodiafiltration, a new process, is widely available and used in particular in europe. this process combines 2 phenomena, diffusion and convection, through high-flux membranes. this process can remove a large quantity of molecule present in blood and especially the middle-molecule. in return, a more important quantity of water soluble vitamins and oligo-elements could be removed by this technique. also, the investigator would like to measure this loss of vitamins and trace-elements in patients with maintenance online post-dilution hemodiafiltration process with dialysate sample and blood concentrations measured (usual patient monitoring) during the session.


Eligibility criteria:
inclusion criteria: * maintenance hemodialysis more than 3 months * 3 sessions per week during 4 hours * hemodiafiltration process used with this patient on lyon sud hospital * flow of the vascular access \> 300 ml/min at least * age \> 18 years * patient able to understand the study's goal exclusion criteria: * active infectious or inflammatory disease * active malignant disease * intestinal malabsorptive disease * polysulfone's dialysis membrane allergy * patient under guardianship and judicial protection * pregnant and breastfeeding woman * opposition to the study
impact of a nutritional intervention on type1 diabetes adult with metabolic syndrome

Conditions: Type 1 Diabetes; Metabolic Syndrome

Summary: recent studies have found that up to 45 % of patients with type 1 diabetes have metabolic syndrome, a cluster of conditions (abdominal obesity, hypertension, dyslipidemia, insulin resistance) that increase the cardiovascular risk. the investigators have observed in previous studies a strong association between the adherence to a mediterranean diet and the prevalence of metabolic syndrome on patients with metabolic syndrome. however, no intervention has been realized on this population and the current recommendations (low fat diet) differ from the mediterranean diet. a nutritional intervention on the principles of the mediterranean diet could therefore play a role in the treatment of the metabolic syndrome in type 1 diabetes patients. the main objective of this study is to examine the impact of a nutritional intervention on the waist circumference after 6 months of an intervention group (mediterranean diet) versus a control group (low fat diet).


Eligibility criteria:
inclusion criteria: * type 1 diabetes for at least 12 months * on intensive insulin therapy with multiple daily injections or on insulin pump * be overweight or obese (bmi≥25 kg/m2) * stable weight for at least 3 months * if on medication for thyroid, hypertension or dislipidemia: stable doses in the last 3 months * presenting at least 3 of the 5 following criteria for metabolic syndrome: 1. waist circumference \>102cm ♂ or \>88cm ♀ 2. triglycerides \>1.7mmol/l or medication 3. cholesterol-hdl \<1.0mmol/l ♂ or \<1.3mmol/l ♀ or medication 4. blood pressure ≥130/85 mmhg or medication 5. estimated insulin resistance (egdr \<6.29) exclusion criteria: * mental incapacity, refusal or linguistic barrier that could affect comprehension or cooperation with the study * ongoing pregnancy * diet corresponding to the criteria of a mediterranean diet (score≥27) * vegetarianism * major diabetes complications
exercise in breast cancer survivors

Conditions: Breast Cancer; Obesity

Summary: the investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.


Eligibility criteria:
inclusion criteria: * \> 18 years of age and \< 65 years of age * female * bmi \> 25 * weight \< 350 pounds * english as a primary language * postmenopausal * invasive er-positive cancer on biopsy and subsequent definitive surgical therapy * received and completed standard of care adjuvant therapy (concurrent endocrine therapy acceptable) * 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization exclusion criteria: * recurrent breast cancer * dcis only (no invasive component) * taking a beta blocker or verapamil * pregnant * wheelchair bound * unable to ambulate independently * concurrent uncontrolled medical or psychiatric disorder * open wound * stage iv breast cancer * progression of disease * bilateral mastectomies

Keywords: breast cancer obesity exercise angiogenesis
the effect of a telerehabilitaion program on gait and balance in patients after hip surgery

Conditions: Osteoarthritis, Hip; Hip Injuries

Summary: the purpose of the present study is to examine whether an intervention plan based on exercise through remote rehabilitation system leads to improvement in characteristics of walking and balance among patients after hip replacement surgery compared to the current conventional way of exercise among these patients.

osteoarthritis is the main and most common reason for replacing hip joint and in forecast for 2020s this will be the fourth reason that causes disabilities throughout the world. osteoarthritis causes not only physical limitation but also damage to the quality of life. pain and functional limitation appear among about 10% of men and 18% of women over the age of 60. pain and limitation in range of movement, functional decrease in daily functioning such as walking distance and endurance, difficulty in climbing up and down stairs are typical signs among those patients before surgery and treatment. other physical defects following hip replacement surgery last for over a year and they include a decrease in muscle strength round the operated hip, a defect in keeping balance in the operated leg and a functional decrease that includes decrease in walking speed, damage in the ability of climbing up and down stairs and difficulty in standing up. physical rehabilitation has importance among patients after hip joint surgery. rehabilitation begins on the first stage at the rehabilitation hospital and continues after discharge at the community, at home or at the clinic. often, the need for a continuing rehabilitation treatment after discharge exceeds the treatment provided actually by healthcare in israel because of various reasons e.g. residence in remote areas, loads of patients who need treatment and high costs of manpower and reaching the treatments. remote therapy is an alternative means to the present therapy in clinics which is provided at the patient's home and thus solving these problems. remote therapy employs technological communication and thus enables the patient to continue the rehabilitation process independently with no need for reaching the clinic which makes it easier for the patient and saves economic costs for the financial agent. the purpose of the present study is to examine whether an intervention plan based on exercise through remote rehabilitation system leads to improvement in characteristics of walking and balance among patients after hip replacement surgery compared to the current conventional way of exercise among these patients

Eligibility criteria:
inclusion criteria: * one to three months after hip surgery * age 50-85 exclusion criteria: * individuals with central neurological disability * dependent individuals in passing from bed to wheelchair * significant cognitive disability according to the attendant physician * individuals with vascular-based pathologies

Keywords: hip surgery replacement
a study to test the long-term use of oral lacosamide in pediatric study participants who completed nct01964560 (ep0034) or nct00938912 (sp848) and received lacosamide treatment

Conditions: Epilepsy

Summary: the purpose of the study is to assess the long-term use of lacosamide oral solution dosed at 2 mg/kg/day to 12 mg/kg/day when administered to pediatric study participants with epilepsy who have completed nct01964560 (ep0034) or nct00938912 (sp848).


Eligibility criteria:
inclusion criteria: * participant is male or female, aged \<6 years at the time of signing the informed consent form (icf) * participant has completed participation in nct01964560 (ep0034) or nct00938912 (sp848) * participant is expected to benefit from participation, in the opinion of the investigator exclusion criteria: * participant has any medical or psychiatric condition that, in the opinion of the investigator, could jeopardize or would compromise the study participant's ability to participate in this study * participant has a known hypersensitivity to any components of the study medication or comparative drugs as stated in this protocol * participant is receiving any investigational drugs or using any experimental devices in addition to lacosamide (lcm) * participant meets a mandatory withdrawal criterion (ie, must withdraw criterion) for nct01964560 (ep0034) or nct00938912 (sp848), or is experiencing an ongoing serious adverse event (sae) * sensitivity to any of the study interventions, or components thereof, or drug or other allergy that, in the opinion of the investigator or medical monitor, contraindicates participation in the study

Keywords: lacosamide vimpat epilepsy pediatric