Kornimate/medical-research-clean huggingface dataset:
texting for diabetes success in pregnancy

Conditions: Gestational Diabetes; Pregnancy in Diabetics

Summary: diabetes during pregnancy can be a challenging circumstance requiring extensive patient learning and self-care. the purpose of this study is to develop and pilot test a patient-centered diabetes education and self-care tool using text messaging to provide supportive messaging and education to underserved women with a pregnancy complicated by diabetes.

low-income, pregnant women in the chicago area are frequently affected by obesity or diabetes. the addition of a disease in pregnancy amplifies the requirements for optimal self-care during pregnancy. this load of information poses a significant burden, particularly for women with additional socioeconomic barriers to self-care. preliminary work suggests patients must overcome a number of social, psychological, and knowledge-based barriers to achieve successful diabetic control in pregnancy. this project involves development and preliminary evaluation of a patient-centered education and self-care tool for use with women whose pregnancies are complicated by diabetes. the study begins with development of a text messaging curriculum to provide motivational and educational support. we will use a one-way, non-interactive text-based educational platform to provide supportive and educational messages to a cohort of 40 women with diabetes. women receive 3-5 text messages per week until delivery. the goal is to develop a program that can be expanded to a clinical trial in which perinatal outcomes are assessed. the primary outcome is patient satisfaction and opinions about the texting program, as measured via a qualitative interview upon study completion. participants underwent an enrollment survey to assess health literacy/numeracy, diabetes self-efficacy, diabetes knowledge, personality, and social hassles. they underwent a baseline in-depth one-on-one interview focusing on barriers to successful self-care with pregnancy and diabetes. follow-up surveys and an exit interview elicited information about their opinions of the texting program. additional goals included determining feasibility for future expansion as a trial.

Eligibility criteria:
inclusion criteria: * pregnant * english-speaking * have gestational diabetes mellitus, type 2 diabetes mellitus, or type 1 diabetes mellitus * age 18 years or older * access to a phone that can receive text messages exclusion criteria: * gestational age greater than 30 weeks * women not meeting the above inclusion criteria
effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain.

Conditions: Asymptomatic Necrotic Teeth

Summary: the purpose of this study is to determine whether the use of triple antibiotic paste as intracanal medication with an anti-inflammatory drug, compared to a calcium hydroxide will reduce postoperative pain and intracanal bacteria or not in patients with asymptomatic necrotic teeth.

this trial is aiming to answer a clinical question whether in patients with asymptomatic necrotic teeth, the use of triple antibiotic paste as intracanal medication with an anti-inflammatory drug, compared to a calcium hydroxide, reduce postoperative pain and intracanal bacteria or not? trial design will be randomized, controlled, double blinded, unicenter, parallel, two-arm, superiority trial with 1:1 allocation ratio.

Eligibility criteria:
inclusion criteria: 1. subject's age between 18-50 years. 2. both male and female subjects. 3. medically free and healthy subjects. 4. mandibular and maxillary single rooted teeth. 5. asymptomatic non vital teeth. exclusion criteria: 1. teeth with acute dentoalveolar abscess. 2. subjects having more than one tooth that require root canal treatment. 3. subjects that have taken analgesic, anti-inflammatory or antibiotic drugs during the 10 days prior to the start of treatment. 4. pregnant females. 5. subjects with systemic diseases who have endocrine diseases, infectious diseases or psychological disturbance. 6. teeth with periodontal disease or pulp calcification. 7. subjects taking chronic pain medications.

Keywords: post operative pain triple antibiotic paste intracanal medication
single dose adductor canal block vs spank block for tka

Conditions: Osteo Arthritis Knee; Pain, Postoperative; Pain, Acute

Summary: this is a prospective, randomized control trial to compare spank block combined with adductor canal block to adductor canal block alone in treatment of post-operative pain after total knee arthroplasty. the primary outcome is pain control, which will be measured throughout the post-operative course using morphine equivalents of opioid analgesics used during the first 24 hours after surgery. secondary outcomes include pain scores recorded at 4, 8, 12, 16, 20, and 24 hours post-operatively, cumulative pain score, incidence of post-operative nausea and vomiting, and extent of motor blockade. the study will aid in answering the question of whether spank block is an effective adjunct in preventing pain and decreasing opioid requirement after tka.


Eligibility criteria:
inclusion criteria: * patients between the ages of 40 and 80 years old undergoing total knee arthroplasty amenable to peripheral nerve block for perioperative analgesia. * bmi \<45 * asa class iii or less exclusion criteria: * inability to sign consent form * allergy to medications used in the study * repeat surgery * history of seizure disorder * simultaneous bilateral tka * history of substance abuse * bmi \>45 * opioid consumption of greater or equal to 30mg morphine equivalents per day * age \ 80 years old * asa iv or greater * inability to use a pca * inability to access the intrathecal space * infection at the site of injection (either for spinal or pnb) * inr greater than or equal to 1.4

Keywords: total knee arthroplasty spank block adductor canal block regional anesthesia
kneipp water applications for insomnia

Conditions: Sleep Disturbance

Summary: the purpose of this study is to ascertain whether warm footbathes are effective on sleep disturbances in women before climacteric.


Eligibility criteria:
inclusion criteria: * minimum age: 18 years * regularly recurring sleeping disease (not less then 2 times a week for minimum 3 month) exclusion criteria: * secundary sleeping disease * mental diseases which require therapy * medication: benzodiazepine,z-drugs, barbiturat, antihistaminika, melatonin * severe comorbidity * gravidity * shift work * voyages (\>3 times during the study) * regulary application of kneipp * participation on other studies to therapy sleeping diseases or stress

Keywords: sleep disturbance footbath kneipp care of sleep sleep
methods study to evaluate use of cardiac ultrasound to assess heart valve abnormality in people.

Conditions: Heart Valve Diseases

Summary: methods study to evaluate use of cardiac ultrasound to assess heart valve abnormality in people.


Eligibility criteria:
inclusion criteria: * \>=18 years of age subjects with stable concomitant diseases with bmi \>=30 kg/m2 exclusion criteria: * pregnant females * those with unstable/new onset diseases * those who are on agents known to be associated with cardiac valvular heart disease
quadratus lumborum block vs transversus abdominis plane block for post-prostatectomy analgesia

Conditions: Prostatic Cancer; Pain, Postoperative; Pain; Anesthetics, Local

Summary: recently, the uses of peripheral axial blocks that deliver local anesthetic into the transversus abdominis fascial plane have become popular for operations that involve incision(s) of the abdominal wall. thus, the transversus abdominis plane (tap) block has been shown to reduce perioperative opioid use in elective abdominal surgery, including open appendicectomy, laparotomy, and laparoscopic cholecystectomy. currently, the quadratus lumborum block (ql block) is performed as one of the perioperative pain management procedures for all generations (pediatrics, pregnant, and adult) undergoing abdominal surgery. the local anesthetic injected via the approach of the posterior ql block ( ql 2 block ) can more easily extend beyond the tap to the thoracic paravertebral space or the thoracolumbar plane, the posterior ql block entails a broader sensory-level analgesic and may generate analgesia from t7 to l1. use of posterior ql block in laparoscopic prostatectomy has not been investigated before and it is the variant that will be discussed in our study.

in laparoscopic prostatectomy, overall pain is a conglomerate of three different and clinically separate components: incisional pain (somatic pain), visceral pain (deep intra abdominal pain), and shoulder pain due to peritoneal stretching and diaphragmatic irritation associated with carbon dioxide insufflation. moreover, it has been hypothesized that intense acute pain after laparoscopic prostatectomy may predict development of chronic pain. without effective treatment, this ongoing pain may delay recovery, mandate inpatient admission, and thereby increase the cost of such care.

Eligibility criteria:
inclusion criteria: * pateints who will have prostatectomy asa ii or iii exclusion criteria: patient refusal local infection at the site of injection allergy to study medications sepsis anatomic abnormalities systemic anticoagulation or coagulopathy inability to comprehend or participate in pain scoring system inability to use intravenous patient controlled analgesia -
relationship of epicardial adiposity with sedentary time, physical activity and performance in hypertensives

Conditions: Hypertension

Summary: epicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals. in the literature, being physically active has been shown to be effective in the treatment of hypertension and reduction of epicardial adipose tissue thickness. the aim of this study was to evaluate the relationship between epicardial adipose tissue thickness and sedentary time, physical activity level and physical performance in patients with hypertension. the study included 40 patients with hypertension. the physical and demographic characteristics of the participants were collected using a sociodemographic form. waist/hip circumference was measured with tape measure and epicardial adipose tissue thickness with echocardiography device. physical activity levels and sedentary time were recorded via ipaq-7. physical performance was determined using the 30-s sit-and-stand test. there is no previous study in the literature evaluating the relationship between epicardial adipose tissue thickness and sedentary time and physical activity levels in hypertensive patients. with this study, we aim to contribute to the literature by filling this deficiency.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * being diagnosed with hypertension for at least 6 months * speaking turkish * to be able to read and write, * to be between 18-65 years old exclusion criteria: * severe valvular disease * be heart failure * being cardiomyopathy * having chronic kidney disease * being thyroid diseases * active infectious or inflammatory diseases * serious psychiatric illnesses such as panic disorder or major depression

Keywords: epicardial adipose tissue hypertension physical activity sedentary time physical performance
dermacyd tina gel tangerina mix - photo evaluation

Conditions: Healthy

Summary: the purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product dermacyd tina gel tangerina mix.


Eligibility criteria:
inclusion criteria: * phototype skin ii and iii * integral skin test in the region exclusion criteria: * lactation or gestation * use of antiinflammatory and/or immunosuppression drugs 15 days before the selection * diseases which can cause immunity decrease, such as hiv, diabetes * use of drug photosensitizer * history of sensitivity or irritation for topic products * active cutaneous disease which can change the study results * history or photodermatosis active * family or personal antecedent of cutaneous photoinduced neoplasias * presence of a precursor lesion of cutaneous neoplasia, such as nevus melanocyte and keratoses actinium * intense solar exposure in the study area * use of new drugs or cosmetics during the study the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: hygiene
total hip prosthesis assisted by computer

Conditions: Clinic Hip Osteoarthrosis

Summary: computer assistance in prosthetic hip surgery is able to improve the accuracy of the surgery: associating hip navigation and eostm imaging pre-operatively could simplify the procedure of hip navigation in lateral decubitus while maintaining the accuracy of the technique

hip navigation based on preoperative eos(tm) imaging could help to improve the accuracy of cup positioning like other computer assisted hip surgery, but it would also simplify the procedure in lateral decubitus. indeed, the registration of the controlateral antero superior iliac spine and the pubis is not necessary with this technique. the target population of the study is the one affected with primitive hip osteoarthritis for which an indication of prosthesis of total hip has been chosen expected result: simplification of the procedure of navigation of the cup. decrease in the number of cups positioned out of the "security zone" compared to the standard manual technique of cup positioning. a result of 50% of good positioning is expected with the manual technique versus 80% with the technique of navigation based on eos(tm). main objective: compare the surgical treatment of total hip prosthesis without assistance by computer and total hip prosthesis with navigation based on imaging eostm pre-operative comparative clinical trial of superiority, randomized in single blind, in 2 parallel groups: -group 1: installation of hip prosthesis without assistance by computer -group 2: installation of hip prosthesis with assistance by computer based on imaging eos(tm)

Eligibility criteria:
inclusion criteria: * nosologic criteria : * primitive clinic hip osteoarthrosis * secondary secondary clinic hip osteoarthrosis : osteonecrosis of femoral head posttraumatic * primitive radiological hip osteoarthrosis, * indication of total hip prosthesis * free informed and written consent, dated and signed by the patient and the investigator before any examination required by the research * subject affiliated or beneficiary of the social security * man or woman aged from 40 to 90 years exclusion criteria: * the navigation based on eostm imaging. requires the visualization on the eostm. pre-operative radiography of 6 radiological bone markers. the non-viewing of these markers is a criterion for exclusion of the study. * anaesthetic contraindication * pregnant women * persons under the control of justice

Keywords: hip arthroplasty navigation
multicenter and prospective clinical registry study of anti-n-methyl-d-aspartate receptor encephalitis in china

Conditions: Anti-NMDA Receptor Enphalitis

Summary: anti-nmda receptor encephalitis is the most common curable non-infectious autoimmune encephalitis，but because of the lack of recognition in the clinic, usually been misdiagnosed as other causes of encephalitis. therefore, it is urgent to establish a database of anti-nmda receptor encephalitis in chinese population. the multi-center, prospective clinical trial of anti-nmda receptor encephalitis in china's , combined with beijing xuanwu hospital, beijing tiantan hospital, beijing children's hospital and other hospitals around the country, by screening the nmda receptor antibody and summarizing the cases analysis, in order to provide evidence for clinical diagnosis and treatment of anti-nmda receptor encephalitis.


Eligibility criteria:
inclusion criteria: 1. older than 6 months. 2. encephalopathy symptoms (change of mental state and consciousness level) persist for more than 24 hours; 3. at least one or more clinical features of the followings: fever, epilepsy, focal neurological deficiency symptoms, changes in csf(cerebrospinal fluid inflammatory), changes in eeg (electroencephalogram), radiographic abnormalities; 4. clinical suspected encephalitis, but conventional detected methods cannot make etiology clear. 5. signed informed consent exclusion criteria: 1. infants less than 6 months; 2. the metabolic encephalopathy; 3. infectious encephalitis with clear pathogen clinically, referring the specific pathogenic microorganisms, including: bacteria, virus, fungus, parasite, spirochete and so on; 4. non-infectious encephalitis with clear diagnosis clinically, including: multiple sclerosis, neuromyelitis optic, acute disseminated encephalomyelitis and so on.
sofaa turkish version study

Conditions: Food Hypersensitivity; Allergy; Phobic Disorders; Caregiver Burden; Validation Study; Cross-Cultural Comparison; Parents; Anxiety; Pediatrics

Summary: this study aims to assess the psychometric properties of the turkish translation of the scale of food allergy anxiety (sofaa), including both child- and parent-report versions. the goal is to validate its reliability and construct validity among children with ige-mediated food allergies and their caregivers in turkey.


Eligibility criteria:
inclusion criteria: * diagnosed with ige-mediated food allergy * at least one parent/caregiver willing to participate * fluent in turkish exclusion criteria: * major neurodevelopmental or psychiatric disorders that impair ability to complete scales
mind-body skills group for graduate students

Conditions: Mood Change; Depressive Symptoms; Anxiety Generalized

Summary: integrative-mind-body skills group (i-mbs-g) is an 8-week group that teaches skills to build inner resources for effective mood management. this group incorporates a holistic approach to wellness through meditation and mindfulness practices, guided imagery, breath and body awareness, and relaxation techniques. mind-body approaches have demonstrated effectiveness in reducing stress mood symptoms and improving quality of life. the study hypothesis is that the mind-body skills taught in the group will reduce mood symptoms in graduate and medical students.

study design: this study will identify medical graduate students interested in participating in an integrative-mind-body skills group (i-mbs-g) to strengthen inner resources to effectively navigate complex and stressful daily events to promote mental and physical health and well-being. this study is a pilot randomized controlled trial; participants will be randomized to the intervention or control group. the control group will receive treatment-as-usual (tau) and mind-body skills reading materials. primary objective: assess the feasibility and acceptability of an i-mbs-g intervention for medical graduate students using the mbsg feedback program questionnaire. secondary objectives: assess preliminary effectiveness of i-mbs-g on anxiety symptoms (i.e., improvements on anxiety symptoms) exploratory objectives: assess preliminary effectiveness of i-mbs-g on depression symptoms (i.e., improvements on depression symptoms)

Eligibility criteria:
inclusion criteria: * students screened and admitted to the student mental health program. * age 18 or older * a score of ≥ 4 on the generalized anxiety disorder scale (gad-7) * able to attend weekly meeting times exclusion criteria: * active si * current mania * active psychosis

Keywords: mind-body skills group intervention graduate student mental health medical student mental health
ketodex versus opioid based anaesthesia in cleft palate repair ketodex versus opioid based anaesthesia in cleft palate repair ketodex versus opioid based anaesthesia in cleft palate repair ketodex versus opioids in cleft palate repaire

Conditions: Ketodex Versus Opioids Based Anaesthesia in Cleft Palate Repair

Summary: this study will be conducted to compare ketodex versus opioid based anaesthesia in cleft palate repair surgeries .

according to patients' randomized groups, study medication is given at induction and continues intraoperative not more than 2hours.\[8\]. induction of anaesthesia with inhalational anaesthetic will be done through a face mask and ayres t piece (sevoflurane )8%on 100% oxygen and fresh gas flow of at least double patient minute volume and iv line will be inserted and secured in place .after confirmation of intermittent positive pressure ventilation , 1.5 mg/kg iv suxamethonium will injected. the child will be intubated with an appropriate sized tube, and a throat pack will be placed. ventilation will be performed with a standard ventilator equipped with a paediatric circle circuit (datex ohmeda, helsinki, finland), tidal volume of 6-8 ml/kg, and a rate adjusted to maintain the etco2 concentration between 32 and 35 mmhg at a total gas flow of 2 l/min. general anaesthesia will be maintained with 50% o2 + 50% air with atracurium and isoflurane, which will be titrated according to the hemodynamic parameters. dexamethasone (0.2 mg/kg) will be given as an antiemetic and to reduce airway oedema. post-intubation, group (kd) will receive 1mg/kg iv ketamine and 1 µg/kg dexmiditomidine iv diluted in 20 ml ns as a loading dose over 10 min followed by a maintenance infusion of ketamine at 0.1 mg/kg/hr and dexmiditomidine 0.2 µg/kg/hr. iv diluted in 20 ml ns till the end of surgery.(15-16-17) group (op) will receive fentanyl 2ug /kg iv diluted in 20 ml ns and another loading syringe containing 20 ml normal saline as a loading dose over 10 min followed by a maintenance infusion of another 20 ml syringes, one containing fentanyl and the other containing normal saline . maintenance dose of fentanyl in this group will be 0.5 µg /kg/hr . pre-operative fasting fluid deficits and intraoperative losses will be replaced with crystalloid. a single shot of intravenous antibiotic will be given. at the end of surgery, patients will be reversed with 0.05mg/kg iv neostigmine and 0.02 mg/kg atropine, and extubated after meeting the standard extubation criteria

Eligibility criteria:
inclusion criteria: * age 6 months to 5 years; both sex, american society of anaesthesiologists' physical status i or ii; no associated any other congenital anomalies. exclusion criteria: * patients with a history of prematurity delayed motor , mental or developmental milestones, long qt syndrome, are excluded from the study allergy to study drugs

Keywords: ketodex, opioids, cleft palate
pleth variability index as a predictor for post-induction hypotension in elderly patients

Conditions: Post-induction Hypotension

Summary: hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect. the post-induction hypotension disrupts organ perfusion and may cause organ damage particularly acute kidney injury, cerebrovascular stroke, and myocardial ischemia. post-induction hypotension occurs with greater frequency and severity in the elderly. this is because of aged-related diminished cardiac reserve and impaired autonomic homeostasis. pleth variability index (pvi) is a software program that measures the dynamic changes of the pi that occurs during a complete respiratory cycle. our primary outcome is to determine the predictive ability and the optimal cut-off value of pre-anesthesia pvi for predicting elderly patients who are at risk of developing post-induction hypotension


Eligibility criteria:
inclusion criteria: * patients with asa physical status i or ii * patients will receive general anesthesia exclusion criteria: * patients with a history of cardiorespiratory disorders * patients with uncontrolled hypertension or cardiac dysrhythmias * patients with renal or hepatic diseases. * patients with long-standing diabetes and peripheral vascular diseases.