Kornimate/medical-research-clean huggingface dataset:
respiratory support and treatment for efficient and cost-effective care

Conditions: Bronchiolitis

Summary: this project aims to answer the essential questions about the management of acute, pediatric respiratory illness, accelerate recovery from these all-too-common diseases, curb unnecessary costs of care, and demonstrate upmc children's hospital of pittsburgh's capabilities as the premier, world-class leader in the arena of pediatric learning healthcare systems. rest eec will focus on the question of whether clinical decision support (cds) facilitates the standardization of the initiation and weaning of heated high flow nasal cannula (hhfnc) for bronchiolitis.rest eec will focus on whether the application of cds improves adherence to a standardized guideline and leads to improved patient-centered outcomes.


Eligibility criteria:
inclusion criteria: * \ 2 exclusion criteria: * immunocompromised * immunosuppressed * chronic lung disease * congenital heart disease with baseline cardiorespiratory manifestations
a cohort study comparing ifx to cs for moderate to severe uc

Conditions: Moderate to Severe Ulcerative Colitis

Summary: the first-line treatment strategy of moderate to severe uc was a important question at issue. the biological agents had potentiality to alter the disease course of uc. the aga clinical guidelines had conditional recommend that ifx and other biological agene migtht be first-line therapy for high-risk uc patints but only had low grade evidence.we launched this multicenter prospective cohort trial to compare the efficacy and safety of infliximab (ifx) and corticosteroids(cs) when they was used as first-line therapy in uc patients.


Eligibility criteria:
inclusion criteria: * moderately to severely active ulcerative colitis, defined as a total score of 6 to 12 on the mayo scale (scores range from 0 to 12, with higher scores indicating more severe disease) and a subscore of at least 2 on the endoscopic component of the mayo scale (subscores on each of the four components of the mayo scale range from 0 to 3) * patients who had colonic involvement of at least 15 cm * patients who had a confirmed diagnosis of ulcerative colitis at least 3 months before screening and confirmed by pathology exclusion criteria: * patients who had previously used any tnf inhibitor * patients who were steroid-dependent or steriod-resistant * patients who had undergone subtotal colectomy or total colectomy * patients who had stoma
additional effects of triamcinolone to hyaluronic acid on knee osteoarthritis

Conditions: Physical Activity; Functional Performance

Summary: using a double-blind, randomized controlled design to investigate the additional therapeutic effects of 3 times of combined triamcinolone and hyaluronic acid injections to 3 times of hyaluronic acid injections to patients with knee osteoarthritis.

a total of 56 patients will be enrolled and randomized into two groups, including 3 times of triamcinolone combined hyaluronic acid injections group and 3 times of hyaluronic acid injections group. the triamcinolone combined hyaluronic acid injections group will receive 3 times of triamcinolone combined hyaluronic acid injection per week in three weeks; the hyaluronic acid group will receive hyaluronic acid injection in three weeks. physical activities and functional performance will be evaluated at before injection, at after one week, one month, three months, and six months of completion of 3 times of injections.

Eligibility criteria:
inclusion criteria: * knee osteoarthritis with kellgren/lawrence grade ii or iii exclusion criteria: * who have neurological deficit, such as stroke who have implant in knee

Keywords: knee osteoarthritis triamcinolone therapeutic effects
effect of emotional freedom technique on postoperative pain and anxiety in patients undergoing total knee replacement

Conditions: Total Knee Replacement

Summary: since pain is a complex and unpleasant feeling that affects the individual physically, mentally and socially, it should be controlled. it is also known that major surgeries such as orthopedics and traumatology, general surgery and cardiovascular surgery cause fear of death in the patient, and this fear is then replaced by general anxiety and post-operative pain. the emotional freedom technique is a method that uses cognitive functions and physical components (tapping acupuncture points) to bring about psychological changes. it is also defined as "needle-free acupuncture" or "an emotional form of acupressure" because it is a gentle, non-invasive procedure and uses acupuncture meridians. this method, which is very old in eastern cultures, started to be used in the west in the 1980s. in this developed technique, all 12 points on the 12 basic meridians, which are the flow paths of the energy in the body, are used. in the emotional liberation technique tour, general anxiety, phobias, post-traumatic stress disorder, fears and the discomfort caused by anxiety are eliminated and all kinds of targeted problems are cured. considering the patients as a whole in terms of biopsychosocial is the basic element of nursing. it is inevitable to experience pain and anxiety in the post-operative period in individuals who are in a foreign environment such as a hospital and who have undergone major surgery such as total knee replacement. with this study, it is expected that the emotional freedom technique will contribute to the national and international literature on the effect of pain and anxiety in the post-operative period and will be a source of information in the development of nursing science on the use of non-pharmacological treatments that can be used in the treatment of pain and anxiety in patients.


Eligibility criteria:
inclusion criteria: 1. elective patients undergoing total knee replacement surgery for the first time, 2. volunteer to participate in the research, 3. 18 years and over, 4. cognitive level scales are suitable for application, 5. having no vision, hearing, or speech problems that would prevent communication, 6. patients who do not have any other disease causing pain and anxiety exclusion criteria: 1. eft was applied before, 2. if any complication develops within 3 days before, during, or after the operation, 3. patients with health problems (fever, infection, dvt, etc.) that prevent the application of the emotional freedom technique were not included in the study.
association of β-amyloid 40 and 42 with prediabetes

Conditions: PreDiabetes

Summary: background: previous epidemiological and animal studies have suggested a strong relationship between prediabetes and alzheimer's disease. recently, we demonstrated that plasma β-amyloid (aβ), a potential biomarker for alzheimer's disease, was elevated in individuals with type 2 diabetes. however, few studies have investigated the associations of plasma aβ40 and aβ42 concentrations with prediabetes. objective: we aimed to investigate the associations of plasma aβ40 and aβ42 concentrations with risk of prediabetes in two independent studies. design: we performed a case-control study and a nested case-control study within a prospective cohort study. in the case-control study, we included 571 newly diagnosed individuals with prediabetes and 571 control participants. prediabetes individuals were consecutively recruited from subjects who attended the outpatient clinics of department of endocrinology at tongji medical college hospital from 2012 to 2015. concomitantly, we recruited healthy controls from a general population undergoing a routine health checkup in the same hospital. one healthy control was selected at random for each prediabetes individuals according to age (±3 years) and sex. the inclusion criteria of participants were as follows: age ≥30 and ≤80 years, bmi \ 80 years were excluded. additionally, 17 cases without enough plasma were excluded. finally, 100 individuals with new-onset prediabetes and 200 well-matched control participants were included for the analysis of the nested case-control study. these two studies were approved by the ethics and human subject committee of tongji medical college. all enrolled participants in the two studies were of chinese han ethnicity and provided informed written consent. plasma aβ40 and aβ42 concentrations were simultaneously measured by validated assay platforms from meso scale discovery (msd; rockville, md, usa).


Eligibility criteria:
inclusion criteria: * age ≥30 and ≤80 years, bmi \<40 kg/m2, screened for prediabetes or diabetes, and with enough plasma collected for β-amyloid 40 and 42 detection. exclusion criteria: * history of diabetes mellitus and prediabetes, pharmacological treatment for hyperlipidaemia, any clinically systemic disease, any acute illness, chronic inflammatory disease or any infective disease.

Keywords: β-amyloid 40 β-amyloid 42 prediabetes
microwave ablation in the treatment of stage i non small cell lung cancer

Conditions: Stage I NSCLC

Summary: lung cancer, the leading cause of cancer related mortality. among them, non small cell lung cancer accounts for 85%. only part of patients could be treated with radical surgery, and some patients were unfit for surgery due to the poor cardio-pulmonary function or refuse surgery. for those patients, microwave ablation (mwa) could be an alternative treatment. several small sample retrospective studies verified that mwa could be an efficacy and safe treatment.

patients with stage i non small cell lung cancer unfit for or refused surgery will be treated with mwa in the primary tumor sites.

Eligibility criteria:
inclusion criteria: 1. patient has a histologically or cytologically verified nsclc, 2. the tumors small enough to treat (usually \<4 cm), and without chest pleura invasion. 3. clinical stage i nsclc with no other sites of disease,. 4. patient is not a candidate for surgical removal of the cancer, or refused surgery. 5. patient is not a candidate for radiation therapy, or refused radiation therapy. 6. patient has \> 6 month life expectancy. 7. eastern cooperative oncology group performance status of 0 to 2. 8. no prior anticancer treatments including surgery, radiation,chemotherapy or local treatments. 9. sufficient organ functions. 10. written informed consent. exclusion criteria: 1. active bacterial or fungous infection. 2. simultaneous or metachronous (within the past 5 years) double cancers. 3. women during pregnancy or breast-feeding. 4. interstitial pneumonitis, pulmonary fibrosis, or severe pulmonary emphysema. 5. uncontrollable diabetes mellitus. 6. history of severe heart disease, heart failure, myocardial infarction within the past 6 months or attack of angina pectoris within the past 6 months.

Keywords: nsclc and stage i and microwave ablation
prevention of myocardial dysfunction and injury resulting from salter innominate osteotomy by caudal block

Conditions: Cardiac Dysfunction; Myocardial Injury

Summary: the goal of the present study was to investigate the role of pro-inflammatory cytokines in myocardial dysfunction and injury resulting from noncardiac injury in children and whether or not anti-inflammatory treatment with caudal block prevents pro-inflammatory cytokines-associated myocardial dysfunction and injury following noncardiac surgery.


Eligibility criteria:
inclusion criteria: * children diagnosed for developmental dysplasia of the hip (ddh) undergoing salter innominate osteotomy will be recruited into the study. exclusion criteria: * children with anemia, electrolyte disturbances, abnormal acid-base status, bleeding diathesis, history of allergy to local anesthetics, neurologic and spinal diseases, skin infections on the caudal area, renal dysfunction, symptomatic cardiovascular and respiratory disease
impact of side to side gastrojejunostomy on the rate of delayed gastric emptying after pancreaticoduodenectomy (ipad)

Conditions: Surgical Technique

Summary: prospective bi-centric randomized open-label study comparing side to side and end to side gastrojejunostomy in pancreaticoduodenectomy

delayed gastric emptying is one of the main complications occurring after pancreatodudodenectomy, the incidence of which is estimated between 10 and 40% in the literature. its occurrence leads to an alteration in post-operative quality of life (maintenance or resting of the nasogastric tube) and is the primary reason an increase in the length of hospital stay and therefore the cost of treatment. in addition, it predisposes to the risk of inhalation pneumopathy, which increases the risk of post-operative death. various technical surgical points have been suggested by retrospective studies to reduce its incidence (pyloric preservation, respect for the left gastric vein, ante-colic positioning of the child's handle, making a y-shaped handle) but without ever being validated in randomized prospective studies. recently three retrospective studies have highlighted the interest of performing a side to side l rather than an end to side gastro-jejunal anastomosis to reduce the rate of post-operative delayed gastric emptying.

Eligibility criteria:
inclusion criteria: * patient over 18 years old * to benefit from a cephalic duodenopancreatectomy whatever the indication (benign and malignant tumor) * affiliated with a health insurance system * having received oral and written information about the protocol and having signed a free and informed written consent. exclusion criteria: * associated organ resection except for portal vein or hepatic artery resection. * history of gastric or esophageal resection * person subject to legal protection (safeguard justice, trusteeship and guardianship) and persons deprived of liberty * pregnant or breastfeeding women * patient participating in another clinical trial that may interfere with the protocol.
bc risk assessment before top surgery

Conditions: Breast Cancer; Risk Reduction

Summary: the population of transgender and gender-diverse (tgd) persons in wisconsin and the u.s. is steadily increasing. as this population grows, the number of individuals seeking gender-affirming therapies, including gender-affirming operations and gender-affirming hormone therapy, is also growing. an example of gender-affirming surgery is chest masculinization surgery, in which most breast tissue is removed in a person assigned female or intersex at birth to allow the chest to appear masculine. gender-affirming chest masculinization surgery is not generally considered equivalent to an oncologic mastectomy, which aims to removal all breast tissue for future breast cancer reduction or current breast cancer treatment. the goals of this investigation are to 1) determine the percent of tgd persons considering chest masculinization surgery who have an elevated lifetime risk of breast cancer development and/or a pathogenic genetic mutation; 2) measure the percent who are at risk and choose to undergo risk-reducing mastectomies as part of chest masculinization surgery; and 3) assess and compare self-perceived breast cancer risk with calculated risk. the results of this study will substantially inform tgd patients and surgeons on the utility of personalized breast cancer risk assessment prior to chest masculinization surgery and the accuracy of self-perceived breast cancer risk in tgd persons.


Eligibility criteria:
inclusion criteria: 1. ≥18 years old. 2. assigned female or intersex at birth and identify as non-cisgender. 3. any individual considering undergoing gender-affirming chest masculinization surgery 4. ability to communicate in english. 5. ability to understand a written informed consent document, and the willingness to sign it. exclusion criteria: 1. \<18 years old. 2. assigned male sex at birth. 3. previously underwent chest masculinization surgery or any form of oncological mastectomy for the purposes of risk-reduction or cancer treatment. 4. any previous or current history of breast cancer, including ductal carcina in situ (dcis). 5. inability to communicate in english.

Keywords: transgender gender diverse nonbinary risk assessment mastectomy top surgery
influence of aerobic exercise on inhibitory control of excutive function in spastic hemiplegic c.p

Conditions: Spastic Hemiplegic Cerebral Palsy

Summary: the study was conducted to assess the influence of aerobic exercise on inhibitory control of executive functions in spastic hemiplegic cerebral palsy.

inhibitory control of executive functions (ef) is one of the main specific cognitive impairments that affect children with cerebral palsy, cognitive skills begin to develop in infancy and continuing through the pre-school years, childhood and into adolescence it changes across the lifespan of an individual and has great effect on their participation and quality of life. the aim of study was to assess the influence of aerobic exercise on inhibitory control of executive functions in spastic hemiplegic cerebral palsy. sixty children with spastic hemiplegic cerebral palsy were enrolled in this study and were assessed for eligibility. their aged ranged from seven and eleven years. they were assigned randomly into two equal groups. group (a) the study group received aerobic exercise in addition to selected physical therapy program. and group (b) the control group received the same selected physical therapy program only. the treatment was conducted for one hour, three times / weak for three successful months. eriksen flanker test and stroop color-word test were used to assess inhibitory control of ef pre and post treatment.

Eligibility criteria:
inclusion criteria: * their aged ranged from seven and eleven years. * they were from both sexes. * they have left side hemiplegic cerebral palsy. * they were able to walk independently. exclusion criteria: * children with visual or auditory problems. * children with history of drug intake that may affect the cognitive function. * medically unstable children especially with cardiovascular disorders. * uncooperative children.

Keywords: hemiplegic cerebral palsy inhibitory control of executive functions. aerobic exercise.
the use of gnrh agonist trigger for final follicle maturation in women undergoing assisted reproductive technologies

Conditions: Sterility; Infertility

Summary: this is a prospective comparative randomized controlled trial investigating the effect of two gnrh agonist trigger protocols on the ongoing pregnancy rate in hyper-responder women undergoing assisted reproductive technology.

follicle maturation triggering is the final differentiation process of an immature egg before fertilization, either in normal or stimulated ovarian cycles in assisted reproductive techniques. this step has traditionally been accomplished by the administration of human chorionic gonadotropin (hcg) trigger which mimics lh activity. however, hcg is a primary cause of severe ovarian hyperstimulation syndrome (ohss) in women and appears to initiate the complex cascade that leads to the development of serious medical complications. numerous strategies have been suggested to prevent ohss; one of these is the administration of a gonadotropin releasing hormone (gnrh) agonist trigger instead of hcg. despite a high safety profile, the gnrh agonist trigger of follicle maturation was found to be associated with a decreased probability of clinical and ongoing pregnancy rates and very high miscarriage rates. a profoundly deficient luteal phase is believed to be the cause of compromised reproductive outcome. our personal clinical practice at the aubmc fertility center seems to indicate that a novel gnrh agonist administration protocol is associated with a comparable reproductive performance to standard hcg trigger. in this study, we aim to validate the above clinical impression and assess associated parameters of success. therefore, a prospective comparative randomized controlled trial will be performed in order to investigate the effect of three repeated doses of gnrh agonist trigger "triptorelin" accompanied by intensive luteal support on the ongoing pregnancy outcome in women who are hyper-responders to ovarian stimulation when undergoing assisted reproductive technology.

Eligibility criteria:
inclusion criteria: * normal uterine cavity (as assessed by hysteroscopy or hsg). * normal hormonal investigation: tsh, prl. * more than 15 follicles (≥12 mm in diameter) on ultrasound, and/or estradiol level of \> 3500 pg/ml on the day of trigger. exclusion criteria: * history of three or more miscarriages. * history of three or more previous ivf failures. * abnormal uterine cavity (hysteroscopy or hsg).

Keywords: gnrh agonist in vitro fertilization assisted reproductive technology follicule maturation pregnancy
a study evaluating the safety, tolerability, and activity of icm-203 in subjects with knee osteoarthritis.

Conditions: Osteoarthritis, Knee

Summary: the purpose of this study is to determine the safety, tolerability, and activity of icm-203, a recombinant adeno-associated viral (aav) vector that expresses a therapeutic gene that promotes cartilage formation, reduces joint inflammation and pain, as well as improves joint physical function, by injecting escalating doses of icm-203 into the knee of subjects with mild to moderate knee osteoarthritis (oa). approximately 6 to 18 subjects will be enrolled into 3 successive dose-escalating groups in a 3+3 study design, whereby 3 study subjects in each group will be dosed sequentially with icm-203 and 3 additional subjects will be dosed at the same dose level if a dose limiting toxicity (dlt) occurs in any of the first 3 subjects.


Eligibility criteria:
inclusion criteria: 1. body mass index (bmi) of 18.0 to 40.0 kg/m2, inclusive, at the time of screening. 2. kellgren-lawrence grade 2 or grade 3 oa of target knee. 3. target knee pain between 4 and 9, inclusive, on an nrs ranging from 0 (no pain) to 10 (worst pain imaginable), at the time of screening. 4. koos function in daily living score \>25, a measure of knee function ranging from 0 (extreme problems) to 100 (no problems), at the time of screening . 5. a stable treatment regimen for symptomatic relief of oa, including nsaids, for 4 weeks prior to screening. exclusion criteria: 1. history of rheumatoid arthritis, psoriatic arthritis, gout, pseudogout, autoimmune oa, chondrocalcinosis, hemochromatosis, villonodular synovitis, and synovial chondromatosis or other disorder that in the opinion of the investigator could cause inflammation of the knee. 2. injection of steroid, hyaluronate or other agent, into the target knee less than 90 days prior to day 1. 3. major injury to the target knee, such as torn ligament or severe sprain, within 12 months of screening. 4. disability so severe that the subject cannot comply with the study requirements, including knee symptoms that result in significant difficulty or inability to walk. 5. surgery on the target knee within 180 days prior to day 1. 6. total knee arthroplasty or other knee surgery planned in the next 12 months. 7. active joint infection or other concurrent medical or psychiatric condition that, in the opinion of the investigator, would make the subject unsuitable for the study.

Keywords: adeno-associated virus gene therapy icm-203 osteoarthritis
clinical characteristics and risk factors of children suffering from inflammatory bowel diseases at assiut university children hospital

Conditions: Inflammatory Bowel Disease

Summary: clinical characteristics and risk factors of children suffering from inflammatory bowel diseases at assiut university children hospital

all patients admitted with inflammatory bowel disease will be subjected to: 1. history: including name, age ,sex ,family history, consanguinity, history of rectal bleeding, mucus or blood in the stool, diarrhea, abdominal pain ,vomiting ,nausea and loss of appetite. 2. examination: including general examination, chest, cardiac, abdominal and neurological examination 3. investigation:including labortatory such as fecal calprotectin ,crp,cbc,esr. endoscopic examination of the gastrointestinal tract histological examination of the biopsies retrieved during gastrointestinal endoscope.

Eligibility criteria:
inclusion criteria: - children aged less than 18 years with a confirmed diagnosis of ibd. exclusion criteria: * children with colitis other than ibd or children with systemic diseases affecting git.