Kornimate/medical-research-clean huggingface dataset:
a cohort study on early stages of heart failure

Conditions: Stages of Heart Failure

Summary: the main goal of this observational study is to learn about the epidemiological characteristics of heart failure among elder population in beicai community in shanghai and construct a community-based database and biobank. the main question it aims to answer is: what is the prevalence and prognosis of different stages of heart failure among elder population in community in shanghai? and what are the influencing factors? what are the best screening strategies and hierarchical management strategies among different stages of heart failure patients in community? participants are the elderly people aged 60 years or older in beicai community in china. the follow-up will be programmed every 2 years.

heart failure is a serious manifestation or advanced stage of various heart diseases with high mortality and re-hospitalization rates, and early diagnosis of heart failure is important to improve patient survival. currently, the prevalence of preclinical heart failure (heart failure stage b) is lacking in china, and the rate of progression of heart failure from stage a/b to symptomatic heart failure (heart failure stage c) and end-stage heart failure (heart failure stage d) and the factors influencing the heart failure development are unknown. the study is an ongoing prospective community-based study. after enrollment, a questionnaire, physical examination, laboratory examination and imaging examination will be administered to each participant at baseline and every 2 years in the follow-up. the laboratory and imaging examination include: blood/urine sample and biochemical measurements, electrocardiogram, echocardiograph, etc. in the follow-up, the incidence of cardiovascular disease, heart failure, other cv events and mortality will be recorded. whether at baseline or follow-up, if the investigators find that patients are unclear about their disease status, the investigators will notify them by phone and record their subsequent medical behavior and results. in this study, a community-based database and biobank will be established for early screening and long-term prognosis of heart failure in elderly population. through the analysis of the data, the epidemiological characteristics of early stage of heart failure in elderly population in shanghai can be identified and a multivariable model predicting heart failure in early stage will be constructed. furtherly，the investigators will explore the referral criteria and hierarchical management strategies for heart failure through the cooperation between community hospitals and comprehensive hospitals.

Eligibility criteria:
inclusion criteria: 1. age ≥60 years 2. cooperate in participating in research and sign informed consent forms exclusion criteria: 1. end stage heart failure patients 2. refusal to participate in this study 3. patients who are not suitable to participate in this study by researchers\&#39;s evaluation

Keywords: heart failure early screening elderly population epidemiology
effect of low-pressure pneumoperitoneum on pain and inflammation post laparoscopic cholecystectomy

Conditions: Pneumoperitoneum; Pain; Inflammation

Summary: the purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.

after obtaining informed consent from eligible study participants. patients were randomized into one of two masked groups, labelled red and green. the red-label group was operated at standard-pressure pneumoperitoneum, while the green-label group was operated at low-pressure pneumoperitoneum. baseline blood samples were obtained pre-operatively for ten inflammatory markers, patients' demographics and intra-operative details collected, then post-operative pain and change in inflammatory markers were followed.

Eligibility criteria:
inclusion criteria: * elective admission for laparoscopic cholecystectomy exclusion criteria: * current or previous diagnosis of acute cholecystitis confirmed by ultrasound * previous gi surgeries, except bariatric and anti-reflux surgeries * currently on immunosuppressant agents * pregnancy * breastfeeding * currently diagnosed with drug addiction * american society of anesthesiologists (asa) score 3 and more

Keywords: low-pressure pneumoperitoneum, lap chole
lifestyle modification in the treatment of nafld.

Conditions: NAFLD

Summary: the project will study the impact of individually tailored lifestyle counselling compared to standard care on the parameters of nafld/nash in patients with metabolic syndrome. the factors affecting the outcome (including clinical and laboratory parameters and microbiome profiling) will be evaluated.

non-alcoholic fatty liver disease (nafld), the hepatic manifestation of a metabolic syndrome, is a leading cause of chronic liver disease worldwide. nafld is associated with type 2 diabetes, obesity and genetic factors. despite intensive effort and numerous trials, as of today there is no approved treatment for nafld. weight reduction is recommended, but no long-term control study assessing the evolution of nafld/nash (non-alcoholic steatohepatitis) during lifestyle modification is available. the main objective of presented project is to compare the progression of nafld/nash in patients with metabolic syndrome randomly assigned to a standard care or a professional lifestyle modification counselling during a 1-yr follow-up. the investigators hypothesize that professionally tailored life-style counselling in patient with metabolic syndrome and nafld will improve liver fat content and other non-invasive parameters of liver disease, and factors (including gut microbiota) affecting progression/regression of nafld will be identified.

Eligibility criteria:
inclusion criteria: * individuals with nafld and metabolic syndrome exclusion criteria: * etiology of liver disease other than nafld. * presence of malignant disease. * uncontrolled cardiovascular disease * pregnancy.

Keywords: nafld cognitive behavioral therapy
myocardial glucose uptake (mgu) in patients with chronic kidney disease

Conditions: Cardiomyopathy; Chronic Kidney Disease; Anemia

Summary: this study examines patients with chronic kidney disease-related anemia and measures changes in the metabolism of the heart using fdg/pet scanning, before and 6 months after their health-care provider has initiated anemia management therapy with the fda-approved drug darbepoetin alfa (aranesp), which is approved for chronic kidney disease-related anemia. the investigators hypothesize that the heart has abnormal metabolism with the anemia of chronic kidney disease but this improves after correction of this anemia with darbepoetin alfa.


Eligibility criteria:
inclusion criteria: * participant must receive care at the vamhcs (va hospital) in baltimore * diagnosed with ckd stage 3 to 5 (egfr of 60 ml/min/1.73m2) and not expected to initiate renal replacement therapy within 6 months * anemia related ckd. * the last 2 serum hemoglobin (hb) values less than 11.0 gm/dl but greater than 8.0 gm/dl * greater than 18 years of age * assessed to be clinically stable by the clinician exclusion criteria: * need for hemodialysis, peritoneal dialysis, or transplantation at the time of enrollment or projected to start within 6 months after enrollment * low functional capacity including inability to walk a flight of stairs with a bag of groceries (nyha class iii/iv heart failure) * prior erythropoietic agents within last 12 weeks * tsat \< 15% and not receiving the recommended dose for iron deficiency * uncontrolled hypertension defined as greater than 180 mm hg systolic or 110 mm hg diastolic * potentially "brittle" diabetes with the propensity for symptomatic hypoglycemia after a 6 hour fast * new diagnosis or ongoing therapy for cancer * pregnancy

Keywords: metabolism myocardium chronic kidney disease
effect of oxalate and urate metabolism on ckd evolution

Conditions: CKD; ESRD; Hyperuricemia; Oxaluria

Summary: the current study primarily aimed to characterize the oxalate and uric acid metabolism in ckd patients and to analyze its association with renal survival prognosis. secondarily, the study is planned to determine whether hyperoxalemia and hyperuricemia are independent risk factors for cardiovascular events and mortality.

the study protocol is approved by a local ethics committee and registered in domestic clinical trial registry (identifier 0119u000002). writing informed consent is obtained from all subjects participating in the study. the study will enroll 300 participants (250 ckd patients at stage 1-5 and 50 healthy subjects). routine biochemical parameters including blood and daily dialysate concentration of urea and creatinine, serum albumin, c-reactive protein (crp), glucose, electrolytes, and lipid profile parameters will carry out. total oxalate-degrading activity in fecal samples, as well as plasma oxalic acid concentration, daily urinary oxalate excretion and peritoneal dialysis effluent oxalate concentration (if any) will determine. uric acid will also measure in serum, urine and dialysate of peritoneal dialysis patients. the study will be followed up for 3 years. the primary endpoint is cardiovascular events, secondary endpoints are dialysis adequacy and all-cause mortality. all the endpoints will be collected, as well as other outcomes, such as chronic inflammation, dyslipidemia and dialysis dose, and so on. the outcomes will be analyzed using statistical software.

Eligibility criteria:
inclusion criteria: * age \>18 years old, * ckd stage 1-4, * the patients did not take antibiotics and/or probiotics, lipid- and/or urate-lowering therapy for at least past 3 months or: * dialysis treatment for at least 3 months, * a stable clinical condition and adequately functioning arteriovenous fistula or peritoneal access, * a target level of kt/v (≥ 1.4 for the hd patients and ≥1.7 for the pd patients). exclusion criteria: * hospitalization in the preceding 3 months, * previous history or actual diagnosis of peritonitis, anemia, systemic and malignant diseases, acute inflammation processes, immunosuppressive treatment and active hepatitis.

Keywords: ckd hemodialysis peritoneal dialysis oxalate uric acid metabolism renal survival cardio-vascular events
injury prevention model for k-1 students

Conditions: Trauma Injury; Child Behavior

Summary: there is no educational injury prevention model uniquely suited for kindergarten and first grade (k-1) students. the teddy bear injury clinic (tbic) is a unique modification of the teddy bear clinic to facilitate classroom injury prevention teaching the tbic will be administered to k-1 students, aged 5-7 years. initial analysis will be descriptive and qualitative. subsequent randomization of students to test and control groups followed by statistical analysis will be done to evaluate for effectiveness of the educational model

the tbic is a 40minute educational intervention divided into two sections with the first section consisting of classroom teaching with two safety messages each for four safety topics and the second section being that of students acting as caregivers for their teddy bears, using role-play for the messages taught. qualitative data collection will be initially done in an inductive manner and qualitative content analysis done using the directed method to analyze effectiveness and appropriateness of the tbic for a pilot group. controlled trial will consist of randomizing students to either the tbic group or the control group which will receive an alternate teddy bear clinic for non trauma related hospital education. pre and post questionnaires will be administered to evaluate the efficacy of the tbic. statistical analysis will be done using the wilcoxon signed test rank score for the likert scale based evaluations generated.

Eligibility criteria:
inclusion criteria: * k-1 elementary school students in the catchment area of the hospital for educational sessions exclusion criteria: * no consent/assent for study

Keywords: injury prevention education model elementary school children
ultrasound by nurses in heart failure patients

Conditions: Heart Failure

Summary: cross-over study aimed to study the diagnostic and clinical impact of routinely adding a pocket-size ultrasound examination to traditional care at a outpatient heart failure clinic.

patient inclusion: outpatient heart failure clinic. patients are eligible for inclusion if the are referred with heart failure and concent to participate in the study. no other exclusion criteria other than no willing/able to give their concent. study population: approximately 80 patients intervention: all participants will undergo careful medical history, physical examination and blood tests led by nurses. all patients will be examined twice (by two nurses), one will routinely add ultrasound examination of the pleural space and the inferior vena cava to assess volume state, the other nurse will not perform ultrasound examination. full cross-over design were nurses do ultrasound examinations at a random matter. patients will then be examined by echocardiography by experience cardiologist's echocardiographers. outcome measures:change in therapy after routinely performed ultrasound examinations vs controls, detection of volume state when performing ultrasound examinations compared to controls with cardiologist's echocardiographic examination as a gold standard. descriptive data of patients before, under and after examinations.

Eligibility criteria:
inclusion criteria: * patients referred to the outpatient heart failure clinic at the local hospital exclusion criteria: * not able or not willing to concent

Keywords: heart failure nurse led outpatient clinic echocardiography pocket-size ultrasound
patient information about options for treatment - pinot

Conditions: Chronic Kidney Disease

Summary: this prospective observational study is designed to find out what treatment options new patients with chronic kidney disease learn about from their renal unit. aims: to determine the proportion of new ckd patients who receive information about treatment options prior to commencing dialysis, pre-emptive transplantation or conservative management. to determine the timing (i.e. patient's stage of disease) when information is given. to find out whether patients have a friend or family member with them when information is given. research design and methods: this study is an assessment of ckd education practices. nephrologists and pre-dialysis coordinators from each renal unit will complete questionnaires about information that was given to each new dialysis, pre-emptive transplant or conservatively managed patient that started treatment during a 3 month period. study hypothesis: approximately one third of ckd patients will receive information after starting treatment. there will be a positive association between in-centre haemodialysis and later referral, non-english speaking background, and advancing age. significance: the results from this national audit will provide australian nephrologists and renal nurses with evidence about ckd education practices and compliance with clinical practice guidelines. the results may highlight opportunities for improvement in practice.

additional research objectives and key research questions: 1. to determine the proportion of patients who receive information about: pre-emptive transplantation; peritoneal dialysis; home haemodialysis; centre based haemodialysis; supported non-dialytic care or conservative management. 3. to determine the proportion of incident patients that have a non-english speaking background (nesb) requiring an interpreter or translated materials. 4. to examine associations between age, gender, health insurance status, nesb, ckd stage and information provided on initial treatment commenced. 5. to determine the proportion of patients who choose not to dialyse.

Eligibility criteria:
inclusion criteria: * patients attending australian adult or pediatric renal units * patients with stage 5 chronic kidney disease commencing dialysis or having a pre-emptive transplant or with decision made for conservative care and egfr \< 15ml/min/1.73m2 between 1st july and 30th september 2009 exclusion criteria: * patients with acute kidney injury not requiring chronic renal replacement therapy * patients with a failing kidney transplant returning to dialysis

Keywords: chronic kidney disease dialysis pre dialysis education transplantation conservative care
assessing perceptions of ml explanations by medical oncologists

Conditions: Oncology

Summary: the objective of this proposal is to conduct a vignette-based survey among practicing oncology clinicians who treat non-small cell lung cancer to assess the trustworthiness of explainable predictions from a neurosymbolic ai vs. state-of-the-art post-hoc explanatory algorithms, using simulated patient data.


Eligibility criteria:
inclusion criteria "medical oncologist" or "hematologist/oncologist" designation at penn treats lung cancer exclusion criteria: non-medical oncologists no email address or physical address listed does not treat lung cancer
effect of topically-applied hyaluronic-acid on palatal epithelial wound closure

Conditions: Wound Healing Complication

Summary: aim of the study is to assess the therapeutic effects of topical hyaluronic-acid use on secondary wound healing of the free gingival graft donor site. the hypothesis of this study is that topical hyaluronic-acid gel has positive effects on secondary wound healing of free gingival graft donor site by reducing pain, burning sensation, and accelerating the healing.

the objective of the randomized, single blind, controlled and parallel clinical trial was to assess therapeutic effects of topical hyaluronic-acid on secondary wound healing of free gingival graft donor site. primary outcome variables that pain and burning sensation changes were assessed at 3, 7, 14, 21 days after surgery by the examiner. pain and burning sensation were assessed by patients using the vas, score 0 indicate no pain or burning sensation, score 10 indicate severe pain or burning sensation. secondary outcome variables included color match, consistency and epithelization of the wound area. these parameters were assessed by the same examiner at 3, 7, 14, 21 and 42 days after surgery. color of the palatal mucosa was assessed by comparing it to that of the adjacent and opposite site using the vas. score 0 indicate no color match and score 10 indicate very good color match. consistency of the palatal mucosa was assessed with a blunt instrumentation and scored as soft or firm. epithelialization was scored clinically as none, partial or complete. sample size has been estimated in 12 subjects per treatment groups. random allocation of the treatment sites to test and control groups will be performed using a computerized selection of random numbers for allocation of the study groups. clinical images obtained at baseline, 3, 7, 14, 21 and 42 days after surgery from each treatment site.

Eligibility criteria:
inclusion criteria: * good general health * no periodontal surgical treatment in the previous 6 months on the involved sites exclusion criteria: * smoking * patients with a pregnancy or lactation period * self-reported history of antibiotic medication within three months * absence of tooth in the area of donor site

Keywords: antiinflammatory gingiva hyaluronic acid palate transplants wound healing
feasibility testing and evaluation of an online toolkit for male spouses of women with breast cancer

Conditions: Breast Cancer

Summary: male partners of women with breast cancer experience distress, so we want to develop a way to support them so they, in turn, can care for their wives. the purpose is to pilot test an online male spouse transition toolkit (matt) that the research team has developed. the specific aims are to: a) evaluate the toolkit for ease of use, acceptability, and feasibility, and; b) collect preliminary data to determine potential effectiveness of the toolkit in increasing hope, general self-efficacy and quality of life, and its potential effectiveness in decreasing guilt scores for male partners of women with breast cancer (stages 1-3).


Eligibility criteria:
inclusion criteria: * male * 18 years of age or older * living with a spouse who has breast cancer (stage 1, 2, or 3) * english speaking. exclusion criteria: * persons who are non-autonomous adults * cognitively impaired as determined by the registered nurse (rn) researcher * unable to participate, in the opinion of the rn researcher * non-english speaking * does not have a spouse who is diagnosed with having breast cancer (state 1, 2, or 3)

Keywords: male caregivers breast cancer intervention online toolkit
safety, tolerability, pharmacokinetics and pharmacodynamics of single-dose gzr4

Conditions: Diabetes

Summary: this trial is conducted in china. the aim of this trial is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single-dose gzr4.


Eligibility criteria:
inclusion criteria: * chinese healthy male adult subjects aged 18-45 years old * body mass index \[bmi between 19.0-24.0 kg/m2 * hemoglobin a1c (hba1c)≤6% exclusion criteria: * abnormalities that were assessed by the investigators to be clinically significant at screening included vital signs, physical examination, laboratory testing, anteroposterior and lateral chest radiography, and 12-lead ecg * known severe allergies (e.g., allergy to more than 3 allergens, allergic asthma affecting the lower respiratory tract, allergy requiring glucocorticoid treatment) or known allergic history to the ingredients of the investigational drug used in this study * participants had donated blood ≥ 200 ml within 6 months before screening, or had donated blood components, or had a total blood loss of ≥ 200 ml due to any reason, or history of blood transfusion or use of blood products * human immunodeficiency virus (hiv) antibody, hepatitis b surface antigen (hbsag), hepatitis c virus (hcv) antibody or treponema pallidum antibody positive * participated in other clinical trials and used investigational drugs or medical devices within 3 months before screening

Keywords: gzr4 pk
enhanced surveillance of rv lead integrity alert (rvlia)

Conditions: Shock

Summary: the purpose is to prospectively monitor the performance of the rv lead integrity alert (lia) upon commercial release.


Eligibility criteria:
inclusion criteria: * lead integrity algorithm download; requires a medtronic device that supports the lia algorithm; requires an rv lead; selected as part of the identified cohort exclusion criteria: * a device that does not support the lead integrity algorithm,

Keywords: lead integrity algorithm