Kornimate/medical-research-clean huggingface dataset:
treatment for nonspecific low back pain in primary care: a trial on different health education booklets

Conditions: Low Back Pain

Summary: the primary purpose of this study is to compare the effectiveness on the disability of low back pain patients of the back book, the back guide, and a control intervention (generic recommendations on general health). patients are divided into 3 groups:those who receive the back book (classic education), those who receive the back guide (cognitive behavioral education) and the control group). they are patients who consult a physician at the primary care consults of 14 different health centers in spain. the sample size is 240 subjects.


Eligibility criteria:
inclusion criteria: * low back pain patients, * with or without referred or radiated pain; * without red flags for systemic disease or criteria for surgery. exclusion criteria: * inability to read the handout or to fill out the questionnaires; * habitually in a prostrate position; * diagnosis of inflammatory rheumatologic disease, cancer or fibromyalgia; suspicion of fibromyalgia.

Keywords: low back pain disability health education primary care
postoperative pain reported to nurses and physicians

Conditions: Pain; Pain Control; Postoperative Pain

Summary: effective pain control following surgical procedures is a goal for both the patient as well as the medical staff caring for them. there have been numerous studies evaluating differing treatment pathways, but most studies have relied on the visual analog scale (vas) or numerical rating scale (nrs) to evaluate outcomes. these scales are subjective score given by the patient with no objective data input, therefore making comparisons subject to possible bias. there are no known studies comparing the pain scores provided by the patient to the surgical team compared to the nursing staff caring for the patient. the aim will be to compare these values to see if patients are consistent in their pain rating.

the project will be conducted as a prospective study comparing numerical rating scale pain scores reported by the patients to the surgical team and the nursing staff. all orthopedic inpatients will be eligible for the study. subjects will not be consented for the study prior to data collection in order to prevent bias. at the conclusion of the patient's involvement in the study they will be informed that their data has been collected and will have the opportunity to opt out of the study, at which time the collected data will be destroyed. postoperatively the surgical team will ask the patient to provide a pain score during morning rounds as part of routine care. the pain score will be recorded by a member of the surgical team. within 60 minutes of their rounds and prior to any pain inducing events (such as physical therapy or repositioning), the surgical team will ask the nurse caring for the patient to enter the room by his/her self and ask the patient the same routine questions including the pain score. the nurse will record the pain score. no member of the surgical team will enter the room while the nurse is present in order to prevent bias. this process will be repeated once a day up to three days for each patient after the patient's operation.

Eligibility criteria:
inclusion criteria: * all inpatient postoperative orthopedic patients will be eligible for the study. exclusion criteria: * if a patient is unwilling to participate in the study.
trial of a novel chitosan hemostatic sealant in the management of complicated epistaxis

Conditions: Epistaxis

Summary: purpose: this study is a prospective clinical trial to investigate the efficacy of a chitosan-coated nasal packing (chitoflex® used in conjunction with the hemcon nasal plug) in the management of difficult spontaneous epistaxis and to evaluate its healing effect on nasal mucosa. the introduction of products that enhances hemostasis can have clinical advantages when associated with traditional nasal packing. these advantages include a better hemostatic control and the reduction of nasal packing duration. furthermore, this study will help determine if there are any non-desirable effects that chitosan may have on the nasal cavity, such as the production of fibrosis and foreign body reaction.

epistaxis is a common reason for emergency department visits and otolaryngology referral. management methods of epistaxis include nasal packing, chemical or electric cauterization, and arterial ligation or embolization. there are numerous nasal packing products available in the market, and are used to stop or prevent nasal bleeding. the ideal nasal pack should be efficient in controlling bleeding, have antimicrobial properties and be well tolerated. currently, there is no perfect nasal pack, but some are closer to ideal than others. nasal packs can be classified into non-absorbable and absorbable nasal packs. recently, a new hemostatic product has been introduced in the market, and used as a military wound bandages, the chitoflex®. chitoflex® is made of chitosan, a naturally occurring, bio-compatible polysaccharide. because chitosan has a positive charge, it attracts red blood cells, which have a negative charge. the red blood cells create a seal over the wound as they are drawn into the bandage, forming a very tight, coherent seal. the chitoflex® -dressing has been demonstrated by aatcc test method 100-2004, evaluation of antibacterial finishes (technical manual of the america association of textile chemists and colorists) as an antibacterial barrier in laboratory testing with a variety of gram-positive and gram-negative bacterial organisms.

Eligibility criteria:
inclusion criteria: * minimum age of 18 years. * epistaxis despite nasal packing or rebleeding after removal of the packing. exclusion criteria: * patient unable or unwilling to provide informed consent. * prior diagnosis of disease or medical condition affecting the ability of blood to clot (e.g., hemophilia.)

Keywords: epistaxis chitosan hemostatic nose bleed nasal bleeding nasal pack sealant chitoflex® hemcon hemcon® chitoflex surgical dressing hemcon® nasal plugs biocompatible dressing
frequency of fibromyalgia in behcet disease

Conditions: Fibromyalgia; Behcet Syndrome

Summary: in various studies, the incidence of fibromyalgia in behçet's patients is widely distributed. it was aimed to investigate the frequency and severity of fibromyalgia in behcet disease in province bursa.

there are few studies in the literature investigating the frequency of fibromyalgia in behçet's disease. in various studies, the incidence of fibromyalgia in behçet's disease was 5.7% -37.1%, which is widely distributed. there are no studies in literature comparing disease severity and pain thresholds at trigger points in fibromyalgia with and without behcet's disease. in this study, it was aimed to investigate the frequency of fibromyalgia in behcet's disease according to the criteria defined by the american colloge of rheuatology in 2010 and updated in 2013. it was also aimed to compare the severity of disease in fibromyalgia with and without behcet's disease.

Eligibility criteria:
inclusion criteria: * patients diagnosed with behcet disease according to international study group criteria * patients diagnosed with fibromyalgia according to classification criteria that were defined by the american collage of rheumatology in 2010 and updated in 2013 * patients older than 18 * patients younger than 75 exclusion criteria: * participants which were previously diagnosed with diabetes mellitus * participants which were previously diagnosed with chronic renal failure * pregnant women

Keywords: fibromyalgia behcet disease trigger points
the effectiveness of oral care with chlorhexidine in medical intensive care unit

Conditions: Ventilator Associated Pneumonia

Summary: oral care with chlorhexidine was used to be considered an effective way to prevent ventilator-associated pneumonia (vap). however, recent evidence revealed that oral care with chlorhexidine may associate with higher mortality and increasing risks of acute respiratory distress syndrome due to the aspiration of chlorhexidine. in addition, the majority of relevant studies in the past have only focused on cardiothoracic intensive care unit (icu) or post-operation patients. thus, whether this is effective and safe for medical icu patients remains unclear.

ventilator-associated pneumonia (vap) is one of the most common hospital-acquired infections in the icu, associated with an increased hospital stay, increased cost of treatment, prolonged ventilator days, and increased morbidity and mortality rates (divatia et al, 2019). the overall incidence of vap was around 12% in asia and nearly 8% in taiwan in the past 30 years (bonell et al, 2019), with a mortality rate that may exceed 45% for those receiving mechanical ventilation (feng et al, 2019). therefore, the prevention of vap is a key part of managing patients undergoing mechanical ventilation. oral decolonization by mouthwash using a chlorhexidine-contained solution was suggested by accumulated evidence in preventing vap (dai et al, 2022). however, controversial opinions existed from a few different points of view. first of all, klompas et al (2014) conducted a meta-analysis that showed the effectiveness of chlorhexidine (chg) oral care in preventing vap was limited only to cardiac surgery patients (klomopas et al, 2014). second, recent evidence showed a possibility of unfavored outcomes related to the use of chg mouthwash by increased mortality either in the icu (price et al, 2014) or the general ward (deschepper et al, 2018). last but not least, the subjectiveness of the diagnostic criteria of vap had led to the discussion on the credibility of the outcome in relevant studies (skrupky et al, 2016). therefore, the us centers for disease control and the national healthcare safety network have proposed alternative diagnostic criteria for the ventilator-associated event (vae) as alternation (peña-lópez et al, 2022). the objective of this study was to examine the effectiveness of oral care with 0.12% chg in micu patients for the prevention of ventilator-associated events.

Eligibility criteria:
inclusion criteria: * patients aged over 20 years old * admitted to micu * an oral endotracheal tube inserted under mechanically ventilated exclusion criteria: * an endotracheal tube inserted over 24 hours before enrollment * intubated because of trauma, burn, operation, or neurological disease * already suffered from oral ulcers before intubation * known history of allergic reaction to chg * use of ecmo
a clinical trial of the transcendental meditation (tm) program on blood pressure, psychological distress, and coping

Conditions: High-normal Blood Pressure; Psychological Stress

Summary: the purpose of this trial is to show that the transcendental meditation program can decrease blood pressure in young adults (college students) and is associated with decreased psychological distress and coping ability.

psychological distress contributes to the development of hypertension in young adults. this was a randomized controlled trial of 296 university students randomly allocated to either the transcendental meditation® program or wait-list control. at baseline and after three months posttest, systolic and diastolic blood pressure, psychological distress (total mood disturbance, anxiety, depression, anger/hostility) and coping ability (global constructive thinking) were measured.

Eligibility criteria:
inclusion criteria: * male or female * currently enrolled in an undergraduate or graduate program through august 2006 exclusion criteria: * history of: * hypertension * hypoglycemia * chronic fainting * coronary heart disease * current systolic/diastolic blood pressure above 140/90 mm hg or below 90/60 mm hg

Keywords: transcendental meditation blood pressure psychological distress high psychological distress
cranirs clinical study

Conditions: Craniosynostoses

Summary: craniosynostosis is a rare disorder characterized by a premature fusion of one or more sutures of the skull. craniosynostosis is usually diagnosed in the first years of life. several complications may be identified if untreated, notably, developmental delay, and vision problems. in some patients with craniosynostosis a decrease in cerebral blood perfusion can be identified. it might be related to the constriction of the brain caused by premature sutural fusion or the localized constriction of venous sinuses. in this study the investigator use the nirs which is defined as a non-invasive technique to monitor hemodynamic parameters and hemoglobin oxygen saturation of the brain during the surgical correction of the craniosynostosis. by applying this method the investigator will be able to analyse the changes in cerebral hemoglobin oxygen saturation related to the modification of the skull. determining changes in brain oxygen saturation by using nirs before, during and after surgery will help both to better understanding the impact of surgical decompression on improving cerebral oxygenation and to better adapt anaesthesia strategies during surgery.


Eligibility criteria:
inclusion criteria: * boys and girls. * aged 3 to 18 months old. * subjects with a craniosynostosis diagnosis confirmed by imaging. * craniosynostosis requiring a corrective surgery in ventral position. * parents/ legal guardian must provide non opposition prior to participation in the study. exclusion criteria: - craniosynostosis planned to be corrected by an endoscopic craniectomy or in dorsal position.
isolated glenohumeral corticosteroid injection versus concomitant capsule preserving hydrodilatation

Conditions: Adhesive Capsulitis; Adhesive Capsulitis of Shoulder

Summary: this clinical trial investigates whether concomitant capsule-preserving hydrodilatation (cshd) is more effective than isolated glenohumeral corticosteroid injection (cs) in treating shoulder adhesive capsulitis. the main questions it aims to answer are * is cshd inferior to cs in immediate pain relief as the solution is diluted? * is cshd superior to cs in improving the range of motion as the contracted capsule is dilated? group cs will receive an ultrasound-guided glenohumeral corticosteroid injection only, with a solution of 5 ml. group cshd will receive an ultrasound-guided glenohumeral corticosteroid with hydrodilatation, with a solution of 20 ml. clinical scores and range of motion will be compared between the groups up to six months post-injection.

a single-centre, double-blinded, prospective randomised controlled trial involving patients diagnosed with adhesive capsulitis of the shoulder (ac). patients were randomly allocated to either corticosteroid injection with hydrodilatation (group cshd) or corticosteroid injection only (group cs). for the cs group, a solution of 1 ml triamcinolone (40mg) and 4 ml 1% lidocaine, 5 ml in total, was injected intraarticularly through the posterior approach using ultrasound guidance. the cshd group received an injection of 20 ml with 15 ml of normal saline added to the abovementioned 5 ml solution. the dilatation of the joint capsule was confirmed by the increase in distance between the capsule and the humeral head. patients underwent the following assessments just before the injection, and at post-injection three weeks, seven weeks, three months, and six months. range of motion in forward elevation, external rotation, and internal rotation clinical scores include the pain visual analogue scale (pvas), the american shoulder and elbow surgeons score, and the constant-murley score. subjective patient satisfaction was recorded on a scale from 0 to 100, with 100 being the most satisfied. the recorded data were compared within each group before and after the injection, and also between the groups.

Eligibility criteria:
inclusion criteria: two or more of the following criteria within the shoulder's range of motion: * abduction and forward elevation below 100˚ * external rotation at the side below 30˚ * internal rotation at 90˚ of abduction below 30˚ exclusion criteria: * history of shoulder surgery, trauma, nerve injury * concomitant rotator cuff/biceps lesions in ultrasound or mri * glenohumeral arthritis in simple x-ray * calcific tendinosis in simple x-ray * underlying conditions: cancer, mental illness, hormonal imbalance * diabetes with hba1c levels exceeding 7.0%

Keywords: glenohumeral injection hydrodilatation corticosteroid injection
comparison of efficacy and safety of insulin detemir and nph insulin in children and adolescents with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: the trial is conducted in europe and middle east. the aim of the trial is to compare the use of insulin detemir once or twice daily combined with mealtime insulin aspart against that of nph insulin once or twice daily combined with mealtime insulin aspart. the trial involves children and adolescents with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes for at least 12 months * informed consent obtained * bmi: 6-7 years: less than or equal to 19 kg/m2, 8-9 years: less than or equal to 20 kg/m2, 10-11 years: less than or equal to 22 kg/m2, 12-13 years: less than or equal to 24 kg/m2 and 14-17 years: less than or equal to 27 kg/m2. * hba1c equal to or less than 12.0% exclusion criteria: * proliferate retinopathy or maculopathy * total daily insulin dose greater than 2.00 iu/kg * any condition or disease that rule out trial participation according to the judgement of the investigator. * mental incapacity, unwillingness or language barriers precluding understanding or cooperation. * a life-style incompatible with trial participation
ckd-330 drug-drug interaction study (amlodipine)

Conditions: Hypertension

Summary: the purpose of this study is to evaluate a pharmacokinetic drug interaction and safety of amlodipine between free combination of amlodipine and candesartan and amlodipine monotherapy.


Eligibility criteria:
inclusion criteria: 1. healthy male volunteer is between 20 and 45 years of age(inclusive) at the pre-study(screening). 2. volunteer who has 19kg/m² ≤ bmi(body mass index) ≤ 26kg/m² 3. when volunteer in screening, must include under the items. 1. 100 mmhg ≤ sitting sbp \<140 mmhg 2. 60 mmhg ≤ sitting dbp \< 90 mmhg 3. 45 bpm ≤ pulse \< 95 bpm 4. those who decided to join the clinical trials by themselves and to comply with the precautions written consent. exclusion criteria: 1. a previous history or present of clinically significant liver, renal, gastro-intestinal, pulmonary, musculoskeletal, endocrine, neuropsychiatric, hemato-oncological, cardiovascular disease. 2. have a gastrointestinal disease history that can affect drug absorption(crohn's disease, ulcers, gerd, gastritis, etc.) or surgery (except simple appendectomy or hernia surgery). 3. the history of clinically significant hypersensitivity reaction about investigational drugs and foods. 4. the history of drug abuse or drug abuse showed a positive for urine drug test. 5. taking drugs have received any other investigational drug within 90 days prior to the first dosing and metabolizing enzyme inducers or inhibitors such as barbitals within 30 days prior to the first dosing. 6. whole blood donation within 60 days prior to the first dosing or plasma donation within 30 days prior to the first dosing. 7. taking drugs that clinical trials expected to affect within 14days or taking food containing caffeine, grapefruit within 7days before the first dosing. 8. a heavy alcohol consumer(alcohol\>3cup/day or 3times/week within last 1month) 9. a heavy smoker(cigarette\>10cigarettes/day) 10. the subject has positive results of serum tests(hepatitis b, c, hiv test, syphilis). 11. have the liver enzyme levels(ast, alt) or bilirubin, total results greater than 1.5 times the unl. 12. have the result of creatinine clearance is less than 80ml/min(cockcroft-gault equation applicable). 13. the result of 12-lead ecg in screening test is qtc\>450msec. 14. an impossible one who participants in clinical trial by investigator's decision including laboratory test result or another reason.
low load resistance exercises with blood flow restriction versus high load resistance exercises

Conditions: Athletes

Summary: practical blood flow restriction (pbfr) is a new technique of reducing the venous return using a band with a pressure that is applied using a perceived pressure scale. the studies that investigate the acute effect of using pbfr and regular high intensity exercises on the level of growth hormone (gh) and blood lactate (bl) after lower extremity training in collegiate athletes are scarce.

practical blood flow restriction (pbfr) is a new technique of reducing the venous return using a band with a pressure that is applied using a perceived pressure scale. the studies that investigate the acute effect of using pbfr and regular high intensity exercises on the level of growth hormone (gh) and blood lactate (bl) after lower extremity training in collegiate athletes are scarce. therefore, this study aimed to investigate the acute effect of a single session low load resistance exercises with pbfr compared to a high load resistance exercises without pbfr on the levels of gh and bl. a convenience sample of collegiate athletes were allocated to either an experimental group that performed low resistance exercises with pbfr or a control group that performed high resistance exercises without pbfr. the levels of gh and bl were examined in 3 time points: pre-training, immediate post-training, and 15 minutes post-training for both groups. analysis of variance (anova) was used to assess the main and interaction effects of the groups.

Eligibility criteria:
inclusion criteria: * student collegiate athletes. * age of 18 years and older. * free from any cardiovascular or respiratory disorders and did not have any injuries during the previous 12 months. exclusion criteria: * students who were taking any medications for chronic conditions. * student who were taking any supplements.

Keywords: blood flow restriction growth hormone blood lactate