Kornimate/medical-research-clean huggingface dataset:
side effects of antibiotics in bone and joint infections

Conditions: Bone Infection; Joint Infection

Summary: treatment for bone and joint infection (bji) is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time. patients are regularly confronted with the adverse effects of these antibiotics, which can lead to loss of adherence and treatment failure. the frequency, severity and impact on quality of life of the adverse effects of long-term antibiotics will be studied in a cohort followed for one year.

treatment for bone and joint infection is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time. patients are regularly confronted with the adverse effects of these antibiotics, which can lead to loss of adherence and treatment failure. although patients with bji receive regular follow-up, the impact of adverse events during treatments lasting more than a month is still poorly developed in the literature. the frequency, severity and impact on quality of life of the adverse effects of long-term antibiotics will be studied in a cohort followed for one year. the investigators believe that this study will improve the management of osteoarticular infections through a better understanding of the adverse effects associated with prolonged, high-dose antibiotic therapy, and encourage more multidisciplinary follow-up.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * microbiologically proven osteoarticular infection with or without material, requiring antibiotic therapy (single or multiple) of 6 weeks or more * oral antibiotic therapy (minimum 4 weeks) exclusion criteria: * opposition to data processing * patient under guardianship or trusteeship

Keywords: antibiotherapy adverse events
development of a mobile application to promote self-care in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to test the efficacy of a mobile application named profibro to promote self-care, and improve symptoms and health-related quality of life in brazilian patients with fibromyalgia.


Eligibility criteria:
inclusion criteria: * diagnosis of fibromyalgia, according to the 2010 american college of rheumatology diagnostic criteria * smartphone user * complete primary education exclusion criteria: * being in physical therapy treatment for fibromyalgia or having been treated in the last 3 months * diagnosis of other chronic pain conditions (neuropathies, rheumatoid arthritis, osteoarthritis, spinal stenosis or cancer) * severe mental disorders (schizophrenia, psychosis, bipolar affective disorder, severe depression) * moderate or severe intellectual disability * hearing or visual impairment

Keywords: fibromyalgia mobile application self-care quality of life
continues cicatricial perfusion of ropivacaine versus placebo after mastectomy : rehabilitation after treatment

Conditions: Breast Cancer

Summary: the acute pain care, in particular after breast cancer surgery must be early and quickly effective, because a severe postoperative pain increases the risk of chronic pain and exposes to a risk of important embarrassment for the realization of simple daily movements. associated to conventional analgesics administered by systemic way, a local anesthesic (ropivacaine) can be continuously infused (continues cicatricial perfusion ccp) in the operating wound by a multi-drilled catheter by means of a elastomeric diffuser set up in the surgical unit by the surgeon at the end the surgical procedure. besides the control of the postoperative acute pain, the local anesthesic could intervene in the prevention of the chronic pain, the early recovery, the reduction of the neuropathic pains and the decrease of needs in morphine after mastectomy. the duration of hospitalization being lower than 48 hours for this type of surgery, the investigators envisage an immediate follow-up in the units of care then at home, what will require a training of the hospital actors and at home (patient, family, visiting nurse, general practitioner). although proposed for several years, the ccp after breast surgery is still a little spread technique and few works had evaluated the pain at rest and at mobilization after mastectomy, the early rehabilitation, and to spread its use towards home, that is why we propose a randomized double-blind study ropivacaine / placebo in patients after mastectomy.


Eligibility criteria:
inclusion criteria: * women \> 18 years, * operated for a breast cancer by mastectomy with or without lymph node dissection, without immediate reconstruction, * capable of understanding the antalgic protocol, * no contraindication to the local anesthesics, * social security affiliation, * signed informed consent. exclusion criteria: * preoperative radiotherapy, * local infection, * contra-indication to the local anesthetic or to ccp, * contra-indication for the use of morphine, * contra-indication for the use of remifentanil, * addiction to opioid analgesics know or not, * allergy to local anesthetics, * hepatic or renal impairment grim known, * previous surgery on the operated breast, * pregnant women, or child-bearing potential, or lactating women, * patient deprived of liberty or under supervision of a guardian.
the capture study: validating a unique copd case finding tool in primary care (aim 2)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this is a qualitative research exploration engaging clinical staff at all levels from 10 practice-based research networks (pbrns) serving us patient populations of differing gender, racial, ethnic, urban/rural and socio-economic blends, in the incorporation of a one-page, five-item questionnaire with selective pef measurement (capture).

this is a prospective, multi-center qualitative study engaging clinical staff at all levels from primary care practices serving us patient populations of differing gender, racial, ethnic, urban/rural and socio-economic blends. the capture tool consists of a 5-item self-administered questionnaire and selected use of peak expiratory flow (pef) measurement, designed to identify clinically significant copd. this study will assess, using the re-aim approach, how real-word primary care practices might potentially use capture to: a) identify target populations (reach); b) appraise optimal targeted respiratory history and symptoms consistent with clinically significant copd (effectiveness); c) integrate into practice workflow (adoption); d) deliver changes and improvements to copd care within the scope of real-world clinical practice (implementation); and e) persist in use and quality over time (maintenance). approximately 150 clinicians from 10 participating primary care practices will undergo detailed implementation investigation of the capture case finding model for clinically significant copd. in addition, 200 enrolled participants will complete a 10-minute written capture opinion survey. using the re-aim framework and consistent phased qualitative analyses, this aim ascertains reach, impact, adoption, implementation and maintenance primary care feasibility recommendation characteristics of capture via pooled assessment of prescriber clinical staff, non-prescriber clinical staff, capture-eligible patients and local pbrn clinical quality improvement expertise from 10 primary care practices across 5 us regions.

Eligibility criteria:
inclusion criteria: clinician participants: 1. provision of signed and dated informed consent form. 2. stated willingness to comply with availability and all study procedures for the duration of the study by the 10 practices (through pbrn recruitment) and their up to 15 clinicians within (through informed consent). 3. male or female, aged 45 - 80 years patient participants \[200 participants enrolled in aim 1 of the capture study for an opinion survey\]: 1. provision of signed and dated informed consent form. 2. stated willingness to comply with all study procedures and availability for the duration of the study. 3. male or female, aged 45 - 80 years. exclusion criteria: 1. clinician participants: current employment at practices participating in aims 1 and/or 3 2. clinician participants: from practices providing fewer than 2 clinician participants 3. patient participants: meeting the exclusion criteria for aims 1 and 3 (above)

Keywords: copd capture chronic obstructive pulmonary disease
a real world study of apatinib in treatment of patients with gastric carcinoma

Conditions: Gastric Carcinoma

Summary: the study was designed to evaluate the efficacy and safety of apatinib in the treatment of patients with gastric carcinoma.

the study is a real-world non-interventional retrospective study and will collect the original medical records of patients with gastric carcinoma treated with apatinib from 2015 to 2018 in henan cancer hospital. clinical data such as patient demographic, history of treatments, tumor biological characteristics and adverse events will be analyzed to evaluate the efficacy and safety of apatinib and explore the risk factors of prognosis in patients with gastric carcinoma.

Eligibility criteria:
inclusion criteria: 1. pathologically or cytologically confirmed gastric or residual gastric or gastroesophageal junction carcinoma; 2. patients received apatinib treatment at least once. exclusion criteria: 1. no specific exclusion criteria in this real world study.
improved diagnosis of ovarian cancer by use of circulating tumor dna as a biomarker

Conditions: Ovarian Neoplasms; Ovary Cancer; Ovarian Cysts

Summary: this project investigates circulating tumor dna (ctdna) in patients with suspected ovarian malignancy. we hypothesize that measurement of ctdna in women with suspected ovarian cancer can improve the diagnostic efficiency for preoperative differentiation between benign and malignant masses. specifically, we hope to determine the diagnostic efficiency of ctdna alone and ctdna in combination with imaging modalities (ultrasonography, mri, pet-ct) and ca 125 for preoperative differentiation between benign and malignant adnexal masses. based on this, we hope to develop an improved diagnostic algorithm. the mutational profile and relation to tumour type, stage, treatment response and prognosis will be explored. analyses of blood and tissue samples will be used to examine the disease development and biology. blood samples, tumour tissue and data on imaging modalities as well as ca 125 will be collected prospectively in consecutive women referred to aarhus university hospital.


Eligibility criteria:
inclusion criteria: * suspected ovarian neoplasm * informed consent exclusion criteria: * inability to give informed consent * previous ovarian cancer diagnosis
does quality of life decline during the covid-19 pandemic and can we change behaviour to improve poor quality of life?

Conditions: COVID; Quality of Life; Behavior; Social Isolation

Summary: the response to covid-19 means social isolation/distancing for the majority of the uk. this has the potential to negatively affect all domains of quality of life (qol). qol can be improved by giving feedback on gaps between someone's perceived qol in a domain and how important it is to them (plus prompting reflective questions). however, interventions that are designed to improve qol may increase the effectiveness of this as optimised behaviour change techniques can be used. this study aims to develop and test a quality of life intervention during social isolation/distancing.

the response to covid-19 means social isolation/distancing for the majority of the uk. this has the potential to negatively affect all domains of quality of life (qol). qol can be improved by giving feedback on gaps between someone's perceived qol in a domain and how important it is to them (plus prompting reflective questions). however, interventions that are designed to improve qol may increase the effectiveness of this as optimised behaviour change techniques can be used. this study aims to develop and test a quality of life intervention during social isolation/distancing.

Eligibility criteria:
inclusion criteria: * adults aged 18+ years * living in united kingdom during covid-19 pandemic. exclusion criteria: * english language - all participants are required to be able to read and understand english to participate.

Keywords: covid behaviour change prevention quality of life social isolation
body psoriasis: long-term relapse control

Conditions: Psoriasis Vulgaris

Summary: this non-interventional study of real-life clinical practice strategies for long-term relapse control in patients with psoriasis vulgaris is planned to enroll 650 adult patients from 60-100 russian dermatology sites and follow the patients for up to 52 weeks. the study will map actual strategies and focus on patients' and dermatologists' experience with the different topicals used, including unspecified products with and without active drugs.


Eligibility criteria:
inclusion criteria: * patients planned to receive topical treatment of any kind to prevent relapse of symptoms * written informed consent exclusion criteria: * contraindications to selected treatment * ongoing systemic treatment of psoriasis with steroids, anti-inflammatory drugs or phototherapy

Keywords: topicals long-term
does placenta pathology predict outcome of neonates with hypoxic ischemic encephalopathy?"

Conditions: Asphyxia Neonatorum

Summary: the histology of the placenta of newborn infants with perinatal asphyxia and hypoxic-ischaemic encephalopathy is analysed. there will be an evaluation if placenta could be a biomarker for neurodevelopmental outcome at 18-24 months of age.


Eligibility criteria:
inclusion criteria:all newborn infants with apgar \ 12mmol/l, base excess \>16, resuscitation \>10min after birth, gestational age \>35 weeks and an encephalopathy - exclusion criteria: -
preventing aggressive behavior in demented patients

Conditions: Dementia; Aggression

Summary: the purpose of this study is to develop and pilot test and non-pharmacological intervention designed to prevent the occurence of aggression in persons with dementia.

an expert panel has met to review the investigators' prior work and literature to help create a non-pharmacological intervention designed to prevent the incidence of aggression. the investigators have created a manual based on prior work and expert input. recruitment for pilot patients is now ready to begin. the purpose of the pilot will be to further adapt the intervention, assess feasibility, and examine recruitment options.

Eligibility criteria:
inclusion criteria: * diagnosis of dementia, * caregiver exclusion criteria: * history of aggression, * residence of nursing homes

Keywords: behavioral research dementia aggression
celebrex - cervix: celecoxib in the treatment of patients with locally advanced carcinoma of the cervix

Conditions: Cervix Neoplasms

Summary: this is a phase i/ii study to evaluate the safety and toxicity of celecoxib in combination with standard concurrent cisplatin and radiotherapy in women with locally advanced cervix cancer. in addition, we aim to determine the effect of celecoxib (celebrex) on tumour oxygenation, interstitial fluid pressure, cox-2 levels, prostaglandin e2 levels, angiogenesis and apoptosis.


Eligibility criteria:
inclusion criteria: * biopsy-proven carcinoma of the cervix, with visible/palpable tumours; figo stage t1b-3b, no/1, mo, to be treated with definitive radiotherapy and chemotherapy * ecog performance status of 0, 1, or 2 * adequate hematologic function; granulocyte count greater than 1.5 x 109/l, platelet count greater than 100 x 109/l * adequate organ function; serum creatinine £ 1.25 x uln, or a calculated creatinine clearance ³ 50 ml/min, serum bilirubin £ 1.25 x uln and ast/alt £ 3xuln * no prior treatment for cervix cancer * informed consent exclusion criteria: * use of an nsaid in the 2 weeks prior to study enrollment * patients with an active malignancy at another site * patients with significant cardiac, renal, or pulmonary disease or any other medical conditions that may preclude radical therapy * patients who have significant history of ischaemic heart disease or stroke who would be deemed not suitable for cessation of their daily prophylactic aspirin * patients with history of peptic ulcer disease or previous nsaid related gastrointestinal bleeding * patients with hypersensitivity to nsaids or celecoxib, or sulfonamides * patients who unwilling or unable to give informed consent
erector spinae regional anesthesia for pain control

Conditions: Pain Management

Summary: interventional study to use erector spinae plane block (espb) on diagnoses of posterior or lateral rib fractures, vertebral fractures, pancreatitis, pancreatic cancer, renal colic, and back pain for multimodal pain therapy to determine its assistance with pain relief as well as the patient's use of opiates after block completion

patients with the listed diagnoses will be offered and then consented for an espb under ultrasound guidance. they will rate their pain before and 30 minutes after the procedure using the ordinal categorical data on a numeric pain scale. total patient opiate use will be gathered up to 8 hours after block completion.

Eligibility criteria:
inclusion criteria: * posterior/lateral rib or vertebral fractures * pancreatitis or pancreatic cancer * renal colic * back pain exclusion criteria: * unstable vitals * infection or open wound over insertion site * prior allergic reaction to local anesthetic * pregnant females * patients \<18 years old * altered mentation

Keywords: erector spinae plane block espb pain reduction
effect of preoperative oral carbohydrate on hypotension after anesthesia induction in elderly patients with joint replacement

Conditions: Carbohydrates; Aged; Post-induction Hypotension

Summary: the goal of this randomized controlled trial is to investigate the effect of shortening the duration of preoperative oral carbohydrate drinks on blood pressure after anesthesia induction in elderly patients undergoing joint replacement surgery. the main question it aims to answer is whether preoperative oral carbohydrate drinks can reduce the incidence of hypotension after anesthesia-induced hypotension in elderly patients undergoing joint replacement surgery.according to the numerical table method, the patients in the experimental group will drink carbohydrate drinks the night before the operation and 3 hours before the operation, and the control group patients will routinely fast


Eligibility criteria:
inclusion criteria: 1. patients undergoing elective unilateral joint replacement (total hip or knee) 2. asaⅰ-ⅲ exclusion criteria: 1. diagnosed patients at high risk of reflux aspiration (diabetes mellitus, obesity (bmi\>30), gastrointestinal obstruction, elevated intracranial pressure, and esophageal disease) 2. eating disorders 3. history of gastrointestinal or epigastric surgery 4. recent use of drugs that affect gastrointestinal motility 5. heart disease (severe arrhythmias, severe heart valve disease, heart failure, unstable angina on the day of surgery) 6. severe poorly controlled hypertension (map≥135 mmhg) or hypotension (map≤55 mmhg) before induction 7. difficult airway 8. severe hepatic and renal insufficiency
musculoskeletal injuries, sports performance, sports specialization, and quality of life in young athletes

Conditions: Sport Injury; Healthy; Injury;Sports; Quality of Life

Summary: the primary aim of this observational cohort study is to assess sports specialization, sports performance, history of injuries (prevalence, types, areas, duration) and quality of life in young healthy athletes aged 8-16 from poland. athlete profiles will be created based on the variables (explained in detailed description) examined. furthermore, the investigators will perform one-year injury follow-up. the main questions it aims to answer are: * do athletes with a specific profile (lower values in athletic performance tests, low values in quality of life) evaluated at one time point, suffer injury in the future in annual observation? * do athletes with high sports specialization will sustain injury in one-year follow-up? * does sports specialization have a relationship with sports performance tests, and quality of life? * does sport specialisation, training volume, geographical factor relate to injury history? * does sports specialisation, injury history differ between sports (individual and team sports)? * does value of the specific muscle (lower limb) isometric strength will be associated with the dynamic balance scores in young healthy athletes?

recruited young healthy athletes (8-16 years-old) from sports schools, clubs, teams will invited to study. there will be performed assessment, which included: * participant characteristics (age, biological age, gender, height, weight, body mass index, sports experience, training workload, sports specialization, history of injuries) * sports performance (value of dynamic balance, isometric strength of lower limbs, functional movement patterns) * quality of life and health assessment (eq-5d-y) * geographical factor (rural, urban) * sports (individual, team) * history of injuries (localization, type) one-year after meetings, there will be send questionaire and phone-call to participants and their coaches/parents in order to obtain information about injuries (location, type, time-loss, etc.).

Eligibility criteria:
inclusion criteria: * healthy (without injury, pain, or symptoms) * participation in sports activities (minimum 6 months) * age of 8 to 16 years-old * agreement to participation from parent/guardian exclusion criteria: * pain or other symptoms related during study * lower extremity or trunk surgery in the last 6 months * lack of medical approval for participation in sports games

Keywords: sports specialization young athletes injury prevention sports performance
pelvic floor muscle training with and without biofeedback in women with stress urinary incontinence

Conditions: Menopause; Urinary Incontinence, Stress

Summary: this study evaluates the action of the pelvic floor muscle training with and without emg biofeddback in the treatment of stress urinary incontinence in menopausal, peri and post menopausal women and their quality of life before and after the interventions.

the pelvic floor muscle training has been the first line of choice in the treatment of stress urinary incontinence. the goal of this technique is increasing the strength and function of the pelvic floor which aims to support the pelvic viscera, as well as part of their duties, such as locks sphincter muscles. risk factors such as advanced age, obesity, multiple pregnancy, can cause a woman to present urinary incontinence (sui), where the main cause is the dysfunction of the pelvic floor muscles and the lack of awareness of these muscles as well as biomechanical problems. some studies describe the use of emg biofeedback to assess and improve the function of the pelvic floor muscles, however, the studies are not yet conclusive about the action of adding this equipment in the treatment of sui. in this regard, the emg biofeedback has the ability to physiologically evaluate these disorders and perform a faster treatment for these patients, improving their quality of life. the emg has the ability to monitor and measure the progression of activation of the pelvic floor muscles, giving feedback to the patient and therapist about the actual condition of muscle function.

Eligibility criteria:
inclusion criteria: will be included in this study: * all women, * spontaneous free will, * have knowledge of research and sign the instrument of consent -tcle. * menopausal women, * pre and post-menopause, * urinary incontinence with the effort exclusion criteria: will be excluded from the study: * patients with neurological, cardiovascular, rheumatologic diseases, * diabetes mellitus, * chronic lung disease, * rheumatoid arthritis, * enhlers-danlos, * sexually transmitted diseases (stds), * do not submit annual gynecological exams.

Keywords: menopause stress urinary incontinence emg biofeedback pelvic floor muscle training quality of life physical therapie