Kornimate/medical-research-clean huggingface dataset:
an investigational immuno-therapy study to assess the safety, tolerability and effectiveness of anti-lag-3 with and without anti-pd-1 in the treatment of solid tumors

Conditions: Neoplasms by Site

Summary: the purpose of the study is to assess the safety, tolerability and effectiveness of experimental medication bms-986016 administered alone and in combination with nivolumab in patients with solid tumors that have spread and/or cannot be removed by surgery. the following tumor types are included in this study: non-small cell lung cancer (nsclc), gastric cancer, hepatocellular carcinoma, renal cell carcinoma, bladder cancer, squamous cell carcinoma of the head and neck, and melanoma, that have not previously been treated with immunotherapy. nsclc and melanoma that have previously been treated with immunotherapy.


Eligibility criteria:
inclusion criteria: * for dose escalation: subjects with cervical, ovarian, bladder and colorectal cancer (crc), head and neck, gastric and hepatocellular cancer naive to immuno-oncology agents; 1st line melanoma and 1st line/2nd line nsclc; renal cell carcinoma naive to io; nsclc progressing while on or after therapy with anti-pd1/anti-pdl-1 and melanoma subjects progressed while-on or after treatment with anti-pd1 or anti-pdl1 with or without anti-ctla-4. * for dose expansion: all of the above in escalation except for cervical, ovarian, and crc * progressed, or been intolerant to, at least one standard treatment regimen, except for participants in 1st line cohorts. * ecog performance status between 0 and 2 * at least 1 lesion with measurable disease at baseline * availability of an existing tumor biopsy sample (and consent to allow pre-treatment tumor biopsy) exclusion criteria: * primary central nervous system (cns) tumors or solid tumors with cns metastases as the only site of active disease * autoimmune disease * encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent * uncontrolled cns metastases other protocol defined inclusion/exclusion criteria could apply
biochemical pregnancy loss. a multicenter retrospective study

Conditions: Pregnancy Loss, Early

Summary: biochemical pregnancy loss (bpl) is a very frequent issue in human reproduction. after the implantation of the embryo, hcg disappears very soon from the maternal bloodstream and no evidence of a clinical pregnancy is seen. different studies showed that factors such as age, oocyte and embryo quality, and endometrium receptivity may have something to do with the occurrence of biochemical pregnancy loss post assisted reproduction treatment. the main aim of this study is to evaluate the incidence of biochemical pregnancy loss (bpl) in three different cohort populations; patients undergoing frozen embryo transfer (fet) from own oocytes after preimplantation genetic testing for aneuploidy (pgt-a), patients undergoing fet from own and donated oocytes and with endometrial receptivity array (era), and patients undergoing fet from own or donated oocytes (without pgta or era test). we will analyse the incidence of bpl in these populations and try to determine the role of the euploid status embryo in the first group, the endometrium in the second group and the third one as control group. we are waiting to find the value of both players in the origin of bpl.

human embryo implantation is a poorly understood process. once the embryo implants in the endometrium, it starts to secrete hcg that can be measured in the maternal blood as early as 9 days after implantation. only a minimal number of pregnancies get to newborn, and the majority are lost before reach the first trimester (larsen et al., 2013). we are looking for the role of the embryo after controlling its chromosomal ploidy, and the endometrium after controlling its transcriptomic expression. we will also use a no exposed group to the controlled euploid embryo factor neither endometrial factor that is the oocyte donation group. this analysis expects to provide more information about the key role of embryo or endometrium in bpl.

Eligibility criteria:
inclusion criteria: patients with the following selection criteria: * ivf/icsi patients aged between 18 and 44 * bmi 18-30 kg/m2 * frozen embryo transfer from own oocytes after pgt-a * frozen embryo transfer with era test (from own or donated oocytes) * frozen embryo transfer (from own or donated oocytes) * single embryo transfer (set) in all cycles * patients without uterine malformations * patients without recurrent miscarriage (≥ 3) * patients with adequate endometrial thickness (\> 7mm) * patients without thyroid autoimmunity * patients without thrombophilia * exclude cycles with exclusively pgt-m * exclude fet in ovarian stimulated cycles exclusion criteria: exclude cycles with exclusively pgt-m exclude fet in ovarian stimulated cycles -

Keywords: pregnancy abortion bioquemical
integrated behavioral health innovations in childhood chronic illness care delivery systems

Conditions: Inflammatory Bowel Disease

Summary: study design: at baseline, all adolescents and young adults with ibd ages 12-21 years will be screened for anxiety and depression symptoms using the phq-9 and the screen for child anxiety related disorders (scared) during a routine medical visit in the pediatric gastroenterology clinic. individuals who screen positive for depression or anxiety will be assessed to confirm diagnoses using the anxiety and m.i.n.i. 6.0. participants will also complete a psychosocial risk assessment as well as medical and socio-demographic inventories. the investigators will include youth that meet full criteria for major depressive disorder and any anxiety disorder, dysthymic disorder, and any adjustment disorder. the investigators will also include patients with subclinical symptoms that have significant psychosocial stressors in addition to their medical illness. patients will be excluded if they have active suicidal ideation with plan requiring er referral, bipolar disorder, psychosis, substance dependence, eating disorders, or significant intellectual disability/developmental delay. participants meeting inclusion criteria will be randomly assigned to four sessions of ibbt administered on-site by a fink social worker or treatment as usual (tau), which is a facilitated community referral for mental health treatment.


Eligibility criteria:
inclusion criteria: * all adolescents and young adults with ibd ages 12-21 years will be screened for anxiety and depression symptoms and includes youth that meet full criteria for major depressive disorder and any anxiety disorder, dysthymic disorder, and any adjustment disorder. the investigators will also include patients with subclinical symptoms that have significant psychosocial stressors in addition to their medical illness. exclusion criteria: * patients will be excluded if they have active suicidal ideation with plan requiring er referral, bipolar disorder, psychosis, substance dependence, eating disorders, or significant intellectual disability/developmental delay.

Keywords: inflammatory bowel disease childhood chronic disease adolescent depression adolescent anxiety integrated brief behavioral therapy adolescent psychosocial risks adolescent chronic disease childhood depression childhood anxiety childhood psychosocial risks
physical activity in children with inherited cardiac diseases

Conditions: Long QT Syndrome; Brugada Syndrome; Catecholaminergic Polymorphic Ventricular Tachycardia; Hypertrophic Cardiomyopathy; Dilated Cardiomyopathy

Summary: use lay language. current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition. their application to the pediatric population has been scarcely evaluated. physical activity is well known for its health benefits but may be dangerous in this population, which leads to confusion within the medical community and among patients. actual physical activity of children with such inherited cardiac disorders is unknown. this study aimed to assess the level of physical activity in children with inherited arrhythmia and cardiomyopathy, and the adherence to the current european guidelines on the subject. secondary objectives aimed to assess through a qualitative analysis the impact of the disease on physical activity and daily life in this population. the level of physical activity and adherence to current guidelines will be determined from interviews between the patient and the principal investigator. each patient will be questioned in order to explore the experiences, motivations and feelings of participants regarding physical activity. the standardized questionnaire was created by the principal investigator and members of the clinical research team. the investigators believe that many children practice physical activity outside the current guidelines and hope to identify the main determinants of physical activity in this population.


Eligibility criteria:
inclusion criteria: children from 6 to 18 years old with clinical and/or genetic diagnosis of : * long qt syndrome * brugada syndrome * catecholaminergic polymorphic ventricular tachycardia * hypertrophic cardiomyopathy * dilated cardiomyopathy * arrythmogenic right ventricular cardiomyopathy exclusion criteria: * presence of extra cardiac co-morbidity with motor or psychological repercussions hingering physical activity * refusal from children or parent to participate in the study

Keywords: arrythmogenic right ventricular cardiomyopathy physical activity inherited cardiac disease peadiarics
extracellular water in covid 19 pneumonia

Conditions: Extracellular Fluid Alteration; Corona Virus Infection

Summary: according to various studies covid 19 pneumonia has a very similar clinical course to acute respiratory distress syndrome (ards) which has clarified by berlin definition. based on this similarity, extracellular fluid of lungs and diffuse alveolar damage should be observed in covid 19 pneumonia as well. extracellular water (ecw) can be determine by using whole body bioimpedence system (ni̇cas). the aim of this study is to investigate the effect of ecw on the clinical apperence of covid 19 pneumonia clinical course.

increase in the extracellular water of lungs is the major pathophisilogy of ards. according to various studies covid 19 pneumonia has a very similar clinical course to acute respiratory distress syndrome (ards) which has clarified by berlin definition. depending on the similarity of covid 19 and ards; evaluation of ecw ,can be a determinant of clinical apperence of covid19 pneumonia. the aim of this study to find the corelation between ecw and severty of the pneumonia. in this prospective -controlled research, the patients who were diagnosed with covid-19 pneumonia will be evaluated. the ones in the intensive care will be considered as severe, and the ones in the ward will be considered as mild clinical course pneumonia. i̇n both groups, in addition to other heamodynamic parametres, ecw will be recorded using non-invasive body biooimpedence method by ni̇cas machine. the total amount of patients will be 52, 26 each two groups. the ward and intensive care patients will be connected to the ni̇cas machine to determine ecw and statistically significantchanges will be recorded. the device consists of a laptop, a software which calculates cardiac parameters and two electrodes. the measurement is done by the following process: one of these electrodes, which looks like ecg electrodes, is stuck to the wrist and the other one to the opposite ankle or each one to two wrists. the severety of illness will try to be detected.gpower 3 for mac os (faul, f., erdfelder, e., buchner, a., \& lang, a.-g. (2009). statistical power analyses using g\*power 3.1: tests for correlation and regression analyses. behavior research methods, 41, 11491160.) was used for istatistical power analysis.the power analysis was done priorly and based on the t-test.in order to provide enoughsample magnitude power, which is 0.8, it was calculated that each group should have 26 patients which makes at total of 52 statistical method: the normal distribution of data will be evaluated using kolmogorov-smirnov test. parametric ones will be used in normal distrubitions, non-parametric ones will be used in abnormal distrubitions. i̇ntergroup ecw values will be compared via independent sample t test. in catagoric data, the comparisons will be made with pearson ki square test, and the p values less then 0.05 will be considered as significant.

Eligibility criteria:
inclusion criteria: covid 19 pneumonia, hospitalized patients older than 18 exclusion criteria: younger than 18 years old, patients not infected with covid 19

Keywords: covid-19 ni̇cas pneumonia
positioning for hip arthroscopic surgery to reduce postoperative numbness

Conditions: Hip Osteoarthritis; Hip Injuries; Hip Sprain; Hip Strain

Summary: compared to the knee and shoulder, the hip joint leaves relatively little space to maneuver arthroscopic instruments and camera. to expand the potential space in the hip joint, traction is commonly applied to the operative leg through a perineal post. this is an effective technique to improve the working space for arthroscopy, however it has been associated with complications, including perineal numbness. traction pads, used alone or with a perineal post, can reduce pressure on the perineal area, thus reducing numbness. the investigators hypothesize that positioning hip arthroscopy patients using a traction pad on a standard traction table with a perineal post will reduce the incidence and duration of postoperative perineal numbness.


Eligibility criteria:
inclusion criteria: * all patients presenting to northwestern memorial hospital (nmh) or to a northwestern orthopaedic surgery faculty member's clinic undergoing hip arthroscopy * ability to read and speak english exclusion criteria: * revision surgery * oncologic surgery * use of regional anesthesia * arthroscopic hip surgery that involves procedures other than labral repair, acetabuloplasty, cam-plasty, it band windowing, iliopsoas lengthening

Keywords: arthroscopy traction
a study to assess the pharmacokinetics of different modified release formulations of gsk221149 in healthy adult subjects

Conditions: Obstetric Labour, Premature; Premature Ejaculation

Summary: preterm labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. oxytocin is a hormone produced by the body during labor. gsk221149 is an experimental drug that will be used to block the effects of oxytocin, and therefore pause or prevent contractions. in this study, the pharmacokinetics of various modified release formulations of gsk221149 will be investigated in healthy non-pregnant adult subjects.


Eligibility criteria:
inclusion criteria: * healthy males and non-pregnant female * between the ages of 18 and 50 years old. * females may be of child-bearing or non-child-bearing potential. * non-smokers * bmi of between 19 and 30 kg/m2 (weight of greater than 110lbs). exclusion criteria: * history of smoking within past 6 months * regular alcohol consumption averaging 7 drinks or more per week * subject is positive for hepatitis c antibody, hepatitis b surface antigen, or hiv * use of prescription or non-prescription drugs within 14 days of study start

Keywords: pre-term labor, modified release formulation pharmacokinetics,
a blood test to look at cells of the immune system in healthy children

Conditions: HIV Infections; HIV Seronegativity

Summary: the purpose of this study is to learn more about some of the immune cells in the blood (cd4 cells, for example) of healthy children in order to better understand the differences in the blood cells of children infected with hiv. because children's bodies are still developing, their cells are different from those of adults, and their bodies respond differently to infections such as hiv. in order to understand how immune cells grow and mature so that they can fight hiv, it is important to see how these cells behave in normal children.

early in life, the cells involved in immune selection differentiate into cd4+ and cd8+ cells. currently there is insufficient information on the cell maturation and activation of these peripheral blood mononuclear cell (pbmc) subsets in normal children. the critical need for this information has been brought about by the pediatric hiv/aids epidemic, which requires the measurement of peripheral blood cd4+ t cells and other cells types for interpretation of hiv disease progression. the immunopathogenesis of pediatric hiv infection differs from that in adults but is not well understood. in order to better understand hiv disease progression in hiv-infected children, these pbmc subsets must be studied in normal children so that control values can be established. healthy infants, children, and adolescents presenting for routine care or elective surgery have a single blood sample obtained. blood is used for complete blood count, peripheral blood mononuclear cell flow analysis for surface markers, and plasma and cell storage. demographic information including age, sex, race, and ethnicity is obtained at the time of the blood draw. the reason for the patient's visit is also documented. no study drugs are administered or supplied as part of this study. statistical analysis is used to estimate the median distribution of each cd4 and cd8 subset.

Eligibility criteria:
inclusion criteria a child may be eligible for this study if he/she: * is 0 - 18 years old. * is hiv-negative and is born to an hiv-negative mother. * is healthy (no serious infection or disease). * has signed informed consent of a parent or legal guardian if under 18. exclusion criteria a child will not be eligible for this study if he/she: * is pregnant or breast-feeding. * has already completed this study once before. * is taking prescription medications other than prescription vitamins.

Keywords: monocytes flow cytometry hiv seronegativity phenotype lymphocyte subsets
multi-slice ct coronary angiography in patients with stable angina

Conditions: Chronic Stable Angina

Summary: early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as ct coronary angiography.

single-center, cross section, observational study included 150 patients with stable angina with normal resting ecg, negative markers, normal systolic function by 2d echocardiography (ef\>50%) and without regional wall motion abnormality at rest who were referred to msct evaluation of the coronary artery tree.

Eligibility criteria:
inclusion criteria: * first attack, low to intermediate risk stable angina * normal resting ecg, * negative markers * normal systolic function by 2d echocardiography (ef\>50%) * without regional wall motion abnormality at rest who were referred to msct evaluation of the coronary artery tree. exclusion criteria: * previous acute coronary syndrome or revascularization, those with renal impairment or dye hypersensitivity, patients with morbid obesity (bmi\>40kg/m²), rhythm other than sinus rhythm inability to hold breath for 10sec to acquire the image lesions with heavy calcium score.

Keywords: chronic stable angina multislice ct remodeling index
personal sound amplification smartphone application feasibility

Conditions: Hearing Loss

Summary: find a personal sound amplification device that can help people hear better.

personal sound amplification devices (psads) have recently become available to the public. psads serve a potentially important role in providing audibility of sounds for adults who find themselves having difficulty hearing and understanding speech in some daily living situations, but may not be candidates for traditional, high-amplification hearing aids. despite hearing loss being a very common problem, few adults who could benefit from some level of amplification actually access the technology. only approximately 1 in 7 adults (14%) over the age of 50 with a hearing loss using amplification. high cost is the most commonly cited reason for not wanting to try amplification, and indeed, hearing aids range from $1000 to $5000 each (i.e., per ear). psads range from $50-$600 each, and may provide a reasonable option for people who are not ready, or are unwilling, to wear a hearing aid. this project aims to examine the feasibility of a psad to provide audible and clear sound signal to adult listeners. the significance of this project is its potential to develop an option for individuals to take advantage of amplification and access sound to improve quality of life, who may not otherwise do so without this technology.

Eligibility criteria:
inclusion criteria: * adults who report difficulty hearing in some daily listening situations. * primarily english-speaking * able to follow instructions and perform study procedures. exclusion criteria: * children * non-english speaking * unable to perform research procedures and/or follow necessary instructions
outcomes of elective colorectal cancer surgery during covid 19 pandemic: implications for cancer care policy

Conditions: Colo-rectal Cancer

Summary: due to covid 19 (corona virus disease)pandemic, majority of surgeries, including surgery for cancer patients got delayed across the globe. surgeries were limited to emergency set up only. at our institute we tried to perform colorectal cancer surgeries through out the pandemic, albeit in less numbers, as we thought cancer in itself is an emergency setting. we are planning to analyse the prospectively managed database of this particular group of patients over a period of last six 6 months and look out at 30 day post operative morbidity and mortality. besides we will try to analyse the implications of our decision to carry on with cancer surgeries in terms of number of health care workers who got infected while being involved in primary care of these patients.

introduction health systems all across the globe have been under tremendous stress due to covid 19 pandemic. based on information suggesting that india was faring better compared to the west \[1\] and that oncology patients were likely to get deferred care with significant implications \[2\], the department of general surgery (colorectal division) took a conscious decision to continue offering elective cancer surgeries albeit in less numbers.in this study we will try to collect 30 day post operative outcome data of elective colorectal cancer resections at our department and discuss the implications of our decision. such reports are still sparsely reported from covid hotspots around the world. methods: we will analyze the prospective database of the department of colorectal surgery at sheri kashmir institute of medical sciences, srinagar, a tertiary referral centre and a high volume centre for colorectal cancer surgeries ( with more than 300 colorectal cancer surgeries performed every year) in north india wef 23rd march to 22nd september 2020 (6 months).and report outcomes of all elective colorectal cancer surgeries. each patient will be followed up for 30 days, thereby last follow up will end on 22nd october 2020. all colorectal cancer patients subjected to elective and emergency surgeries during covid 19 pandemic will be included. patients who were positive for sars cov2 (severe acute respiratory syndrome coronavirus 2) infection and underwent surgery for colorectal cancer will be excluded. the data will be statistically analysed using statistical product and statistical solutions(spss) sotware v 23. all categorical variables will be shown in the form of frequency and percentage. continuous variables will further be analysed by independent t test and using multivariate analysis.

Eligibility criteria:
inclusion criteria: * colorectal cancer patients subjected to surgery during covid 19 pandemic exclusion criteria: * sars cov 2 infected patients

Keywords: colorectal cancer covid 19 pandemic