Kornimate/medical-research-clean huggingface dataset:
effect of ani on intraoperative opioid consumption

Conditions: Analgesia; Nociceptive Pain; Nerve Block; Pain

Summary: the aim of the study is to compare the analgesic nociception index (ani), which is used to determine the dose of analgesic agent needed in the intraoperative period, with the conventional method in patients with erector spinae block who underwent gynecological surgery under general anesthesia.


Eligibility criteria:
inclusion criteria: * asa i-ii-iii risk group * patients who underwent gynecological surgery under general anesthesia, who underwent erector spina block, and whose pain was followed by analgesia nociception index or conventional methods for intraoperative pain monitoring * patients whose informed consent was read and consent was obtained from them and their guardians exclusion criteria: * cardiac rhythm disorder * central-autonomic nervous system disease * neuropsychiatric disease * receiving opioid therapy * use of drugs that will affect cardiac autonomic regulation * known allergy to the drugs to be applied * contraindicated for esp block * patients who do not agree to participate in the study will not be included in the study. * patients who were administered drugs to stabilize the patient's hemodynamics during the operation

Keywords: analgesia nociception index pain monitoring analgesia
virtual reality in teachers' vocal motor behavior acquisition (virtuvox)

Conditions: Voice Disorders; Virtual Reality Therapy

Summary: scientific literature supports that teachers are at greater risk for voice disorders than the general population. in the classroom, the teacher's voice represents the main communication tool. optimal voice use is indispensable to ensure effective teaching and preserve the teacher's vocal health. this project investigates how virtual reality (vr) facilitates the learning of effective vocal skills and their application in real-world contexts. based on acoustic analyses and self-assessment scales, the investigators compare 100 future teachers randomly assigned in two groups. the experimental group (n=50) receives a voice training by vr simulations and voice information. the control group (n=50) only receives voice information.

experimental group participants receive direct method (three 1-hour sessions of voice training by virtual reality simulations over a course of 3 weeks) and indirect method (one 1-hour session of information on voice function and voice hygiene). control group participants receive indirect method (one 1-hour session of information on voice function and voice hygiene).

Eligibility criteria:
inclusion criteria: * future teacher having completed at least one internship as a schoolteacher * speaking french fluently exclusion criteria: * hearing impairment * voice pathology at the time of the study

Keywords: speech therapy virtual reality teacher's voice background noise school teachers
microbiologic findings of acute facial palsy in children

Conditions: Facial Paralysis

Summary: objective: microbiologic etiologies of facial palsy in children were investigated. study design: prospective clinical study. methods: forty-six children aged 0-16 years with facial palsy comprised the study group. paired serum samples and cerebrospinal fluid were tested to find indications (antibodies, growth of the microbe, or nucleic acids) of microbes putatively associated with facial palsy. the microbes tested were herpes simplex virus-1 and -2, varicella-zoster virus, human herpesvirus-6, mycoplasma pneumoniae, borrelia burgdorferi, influenza a and b-, picorna-, cytomegalo-, parainfluenza-, respiratory syncytial-, coxsackie b5-, adeno-, and enteroviruses, chlamydia psittaci, and toxoplasma gondii. besides the routine tests in clinical practice, serum and cerebrospinal fluid samples were tested with a highly sensitive microarray assay for dna of herpes simplex virus-1 and -2, human herpesvirus-6a , -6b, -7, epstein-barr-, cytomegalo-, and varicella-zoster viruses.


Eligibility criteria:
inclusion criteria: * age 0-16 * facial palsy

Keywords: facial paralysis, facial nerve, borreliosis, bell's palsy
a comparative study between oncoplastic breast surgery and standard conservative surgery:margin status and patient satisfaction

Conditions: Breastcancer

Summary: this non randomized study is a comparative study between standard conservative breast surgery and oncoplastic surgery as regard margin status and patient satisfaction.

this planned study was conducted on 70 female patients presented to our tertiary referral breast unit at ain shams university hospitals with breast cancer amid the period from september 2012 to may 2013 . every one of them signed an informed consent to partake in this study that was approved in a meeting held by the ethical committee on august 2012 at ain shams university. all patients sharing in the study received closed envelope before surgery in a randomized way in which the surgical technique is written either standard conservative surgery or oncoplastic surgery(double blind). our patients were partitioned into 2 equal groups: group a (35patients) who underwent standard conservative surgery, group b (35patients) who underwent oncoplastic surgery.

Eligibility criteria:
inclusion criteria: * female patients with stage 1,2 breast cancer. exclusion criteria: * patients \>60 years. * patients with previous breast surgery. * patients candidate for mastectomy or palliative excision. patients with collagen disease.

Keywords: oncoplastic surgery standard conservative surgery patient satisfaction margin status
copy number variation in chrna7 gene in migraine and gene expression

Conditions: Migraine

Summary: migraine is a common and possible hereditary disease. copy number variation (cnv) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.the chrna7 gene has a major role in the neuropsychiatric phenotypes observed in patients. the 15q13.3 gain/loss variation in this gene may be associated with migraine.

migraine is a common neurological disorder. although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. neuronal acetylcholine receptor subunit alpha-7, also known as nachrα7, is a protein that in humans is encoded by the chrna7 gene.

Eligibility criteria:
inclusion criteria: migraine exclusion criteria: vascular problems
safety and pharmacokinetics of abicipar pegol intravitreal injections in japanese patients with neovascular amd

Conditions: Macular Degeneration

Summary: this study will evaluate the safety and to characterize the systemic pharmacokinetics of free and vascular endothelial growth factor (vegf)-bound abicipar following multiple monthly intravitreal injections of abicipar in japanese patients with neovascular age-related macular degeneration (amd).


Eligibility criteria:
inclusion criteria: * japanese male or female patients * presence of active subfoveal and/or juxtafoveal choroidal neovascularization (cnv) secondary to age-related macular degeneration (amd) exclusion criteria: * history of or active periocular, ocular, or intraocular infection * previous use of ocular anti-angiogenic therapy within 1 month (ranibizumab), 6 weeks (pegaptanib), or 2 months (bevacizumab and aflibercept) of day 1 for the treatment of neovascular amd or neovascular eye diseases other than amd * macular hemorrhage that involves the center of fovea in the study eye * previous use of verteporfin photodynamic therapy (pdt) or previous therapeutic radiation in the region * treatment with ocular corticosteroid injections or implants within 6 months in the study eye * history or evidence of eye surgery: pars plana vitrectomy, submacular surgery or other surgical interventions for amd, incisional glaucoma surgery or cataract or refractive surgery within the last 3 months * amd or neovascular eye diseases other than amd in the non-study eye that require anti-vegf treatment
accuracy of coplanar template assisted seed implantation for abdominal and pelvic cancer

Conditions: Accuracy of Coplanar Template Assisted Seed Implantation for Abdominal and Pelvic Cancer

Summary: in recent years, template guidance has been applied and developed in the field of puncture related operations, such as template-assisted radioactive seed implantation. with the guidance of template, needle pathway of seed implantation, biopsy and fiducial marker implantation can be precisely planned actual operation, which is conducive to the accurate proceeding. templates can be divided into coplanar templates and non-coplanar templates. the digital coplanar template coordinate puncture system has been developed in china and has been applied in clinical practice. in previous studies, coplanar template assisted ct-guided radioactive seed implantation has good clinical feasibility for head and neck cancer. however, the accuracy of coplanar template assisted seed implantation for abdominal and pelvic cancer are lacking in prospective studies. the study aims to prospectively observe the accuracy and safety of coplanar template assisted seed implantation for abdominal and pelvic cancer.


Eligibility criteria:
inclusion criteria: 1. ages 18 to 85 2. single or multiple abdominal or pelvic tumors (solid, partially solid) 3. without taking drugs affecting coagulation and/or platelet aggregation are used; if used, the drug has been discontinued for a sufficient period of time (e.g. 1 week) 4. kps\>60 points with expected survival \>3 months, no serious or uncontrolled underlying diseases, clinical evaluation patients can tolerate puncture 5. planned seed implantation with applicable puncture path 6. with informed consent. exclusion criteria: 1. poor organ function (e.g. liver decompensation) 2. the lesion close to blood vessels and intestine, or there is portal vein hypertension and superior vena cava compression, etc., which are expected to have high risks of puncture bleeding and intestinal injury 3. poor compliance, unable to complete coordination 4. paticipant who is considered inappropriate or unwilling to participate in this clinical trial for other reasons.

Keywords: coplanar template abdominal and pelvic cancer seed implantation
arthroscopic midcarpal wrist arthrodesis: clinical and functional outcomes

Conditions: Dislocation of Midcarpal Joint

Summary: all cases of midcarpal wrist arthritis treated surgically with arthroscopic partial wrist fusion with cannulated screws from january 2015 to december 2017 will be reviewed. the union rate and time to union will be recorded following the standard radiological postoperative control. wrist assessments performed pre- and postoperative regarding strength, range of motion and pain will be analysed. complications will be recorded as well. participants will be recruited for wrist assessment. they will be asked to fill out questionnaires about the functional result related to their quality of life.


Eligibility criteria:
inclusion criteria: 1. all the patients suffered from traumatic or degenerative mid-carpal wrist arthritis or instability and treated surgically with arthroscopic midcarpal wrist arthrodesis in the division of plastic surgery and hand surgery university hospital zürich from january 2015 to october 2017 will be included. 2. signed informed consent for participation in the study and for further use of collected data. exclusion criteria: 1. missing informed consent

Keywords: arthroscopy wrist osteoarthrosis
app based study on the symptoms of patients with allergic rhinitis in the pollen season

Conditions: Allergic Rhinitis

Summary: app-based study of allergy patients under medication in the pollen season to determine the effect of allergic rhinitis on the quality of life.

the project aims to determine the effects of rhinitis on everyday life and thereby identify the affected pathways, irrespective of age, gender or gender socioeconomic status to lead a healthy and active life.

Eligibility criteria:
inclusion criteria patients with allergic rhinitis exclusion criteria none

Keywords: immunotherapy
right versus left thoracic surgical approaches for siewert ii gastroesophageal junction adenocarcinoma

Conditions: Siewert Type II Adenocarcinoma of Esophagogastric Junction

Summary: to explore the 5-year overall survival (os) of right versus left thoracic surgical approaches for patients with locally advanced siewert ii gastroesophageal junction adenocarcinoma treated by neoadjuvant chemotherapy


Eligibility criteria:
inclusion criteria: 1. histologically confirmed gastroesophageal adenocarcinoma; 2. r0 resectable siewert ⅱ, ct2-3n0-3m0 (ajcc v8 tnm classification); 3. have a performance status of 0 or 1 on the ecog performance scale; 4. age 18-80 years old, both men and women; 5. estimated survival ≥6 months; 6. be willing and able to provide written informed consent/assent for the trial; 7. demonstrate adequate organ function ; 8. female subject of childbearing potential should have a negative urine or serum pregnancy within 7 days before enrollment. if the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required; 9. have not received systemic or local treatment for esophageal cancer in the past. exclusion criteria: 1. have a history of other malignant tumors in the past or at the same time; 2. previous upper abdominal surgery (excluding cholecystectomy); 3. bleeding, perforation and obstruction requiring emergency surgical treatment; 4. severe heart, lung, liver and kidney dysfunction, which the researcher thinks is not suitable for operation; 5. hydrothorax and ascites with clinical symptoms need therapeutic puncture or drainage; 6. participate in other clinical studies or less than 1 month from the end of the previous clinical study; 7. have a history of psychoactive drug abuse, alcoholism or drug abuse; 8. be unable or do not agree to bear the inspection and treatment expenses at their own expense; 9. the researcher thinks that it should be excluded from this study.

Keywords: gastroesophageal cancer surgical incision left thoracic incision right thoracic incision neoadjuvant chemotherapy
ease-it spray for the treatment of fire ant stings

Conditions: Insect Bites and Stings

Summary: the application of ease-it spray will alleviate pain secondary to fire ant stings more quickly than placebo.


Eligibility criteria:
inclusion criteria: * ad soldier in us army * ages 18-60 * volunteer * absence of serious medical condition * past allergic reactions * asthma * history of (h/o) ifa sting exclusion criteria: * inability to provide informed consent * known h/o hymenoptera allergic reaction * allergy to any component of the treatments * inability to follow-up * active medical condition * pregnancy
texting for mobility in overweight/obese adults with peripheral artery disease

Conditions: Overweight and Obesity

Summary: by doing this study, researchers hope to learn about the feasibility of using a mobile application to help overweight or obese adults with pad increase their walking distance and lose weight.

peripheral artery disease (pad) or poor leg circulation affects 8 to 12 million americans including non-hispanic whites, african americans and latinos. having pad can limit how far you can walk. many patients with pad are also overweight or obese. weight loss among overweight or obese adults with pad may improve walking distance. given how common obesity or being overweight is among persons with pad, interventions are needed to address weight loss in this population.

Eligibility criteria:
inclusion criteria: * overweight or obese (body mass index \>=27 kg/m2) * have symptomatic pad * english speaking * have 24 hour access to a cell phone exclusion criteria: * cannot tolerate fruits and vegetables, fiber, and/or a low fat diet, as informed by a physician and/or registered dietician * restricted intake of water * pregnancy * prior major amputation (foot or lower leg) or critical leg ischemia (tissue loss, gangrene, or ulcers) * use of supplemental oxygen * heart attack within preceding 3 months

Keywords: text messaging pad
cognitive behavioural therapy versus psychoeducation for perinatal anxiety

Conditions: Perinatal Anxiety

Summary: anxiety during pregnancy and the postpartum (perinatal) period is very common and is associated with adverse consequences for mothers and their infants. currently, medication is the most commonly prescribed treatment for perinatal anxiety and the lack of nonmedication-based interventions for perinatal anxiety is a barrier to receiving effective treatment for many women. as such, the present single-blind, randomized controlled trial seeks to evaluate whether group-based cognitive behavioural therapy, the gold-standard psychological treatment for anxiety disorders in the general population, effectively treats perinatal anxiety symptoms when compared to a psychoeducation group, which is currently the most commonly prescribed non-medication-based treatment for perinatal distress.


Eligibility criteria:
inclusion criteria: 1. women 18 and older that are pregnant or between 0-12 months postpartum; 2. principal diagnosis of an anxiety disorder as per the mini international neuropsychiatric interview for dsm-5 (version 7.0.2) with or without comorbid depression; 3. no concurrent psychological treatment; 4. not taking psychoactive medication or a) medications are stable in dose and type for at least 8 weeks prior to the study (as per canadian psychiatric guidelines; and b) medications remain stable throughout the study; 5. fluent in english, minimal grade 8 reading level. exclusion criteria: 1. severe depression/suicidality requiring acute intervention; 2. women with psychotic or current substance use disorders, 3. medication changes in dose or type or less than 5/6 sessions complete (will continue with treatment but be excluded from the study).
effectiveness of eye mask and headset in primary headache

Conditions: Primary Headache Disorder

Summary: primary headache can be triggered by light or noise. getting rest in a quiet and dark environment for the treatment of acute headache is recommended for relief of pain during an attack. it is hard to provide this kind of environment in a busy emergency department. we aimed to determine if eye masks and noise reduction head sets are effective in reducing pain scores, fastening pain relief when used together with standard care. we also aimed to see if these methods were preferred over standard care.


Eligibility criteria:
inclusion criteria: * patients with current headache as a chief complaint presenting to emergency department * triage category 3,4,5. * preliminary clinical diagnosis of primary headache is made after brief history and physical exam by the attending emergency physician according to international classification of headache disorders version 3 * the attending physician ordered iv treatment exclusion criteria: * pregnant * known or suspected diagnosis of a secondary etiology of headache at presentation or at any point during the emergency department visit * head trauma within 14 days * inability comply with the study due to insufficient knowledge of turkish language * known allergy to standard treatment or rescue treatment * history of gi bleeding in the last year * taking any analgesic drug in the last four hours or taking the maximum dose of standard treatment before coming to emergency department * hepatic or renal failure * patients with hearing or vision loss
mascot study: management of atrial fibrillation (af) suppression in af-heart failure (hf) comorbidity therapy

Conditions: Heart Failure; Atrial Fibrillation; Ventricular Dysfunction

Summary: the purpose of this study is to evaluate whether adding af suppression™ to cardiac resynchronization therapy (crt) improves the prognosis of heart failure patients benefiting from cardiac resynchronization therapy.


Eligibility criteria:
inclusion criteria: * hf patients * new york heart association (nyha) iii - iv * spontaneous qrs ≥130 ms and/or mechanical interventricular delay \> 50 ms * left ventricular ejection fraction (lvef) ≤ 35% * left ventricular end diastolic diameter (lvedd) ≥ 55 mm * optimized medical regimen * age \> 18 years exclusion criteria: * unstable angina or acute myocardial infarction (mi) (\< 3 months) * coronary artery bypass grafting (cabg) or percutaneous transluminal coronary angioplasty (ptca) \< 3 months * life expectancy \< 6 months * permanent af * pregnancy

Keywords: ventricular dyssynchrony
a 1-year comparison of generic tacrolimus (tacni) and prograf in renal transplant patients - a retrospective matched pair analysis, gentac

Conditions: Renal Transplantation

Summary: this is a retrospective analysis of two different cohorts of patients that has undergone renal transplantation. this is a matched pair analysis of 100 patients treated with generic tacrolimus that will be compared with 100 matched controls treated with prograf. data will be obtained from patients' charts, from the swedish national kidney registry and from a local registry at transplantationscentrum. patients included in the study are patients receiving a first single kidney transplant from a deceased or a living donor, treated with prograf or tacni and transplanted between transplanted january 2012 and august 2014. the 1-year-outcome of patients following renal transplantation, including bpar, serious adverse effects and graft survival will be analysed.


Eligibility criteria:
inclusion criteria: * patients receiving a first single kidney transplant from a deceased or a living donor. * patients treated with prograf or or generic tacrolimus * patients transplanted between 1 october 2012 and 1 august 2014 exclusion criteria: * multi-organ transplants * re-transplantations

Keywords: biopsy-proven acute rejection graft loss graft survival