Kornimate/medical-research-clean huggingface dataset:
the flow diverter for treating patients with intracranial aneurysms

Conditions: Intracranial Aneurysm

Summary: to evaluate the efficacy and safety of the blood flow guide device manufactured by jiangsu changyida medical technology co., ltd. for endovascular embolization of intracranial aneurysms


Eligibility criteria:
inclusion criteria: ●≥18 years old and ≤75 years old, male or unpregnant female * untreated and unruptured intracranial wide-necked aneurysm confirmed by preoperative imaging diagnosis (wide-necked aneurysm was defined as the tumor neck ≥4mm or the tumor body/tumor neck ratio \<2) * the target aneurysm is planned to be treated with blood flow guidance device only, without the need to complete the treatment by stages * the width of tumor neck should be less than 30mm * imaging measurements of the tumor parent artery showed that the diameter was 1.5mm \~ 6.5mm * the subject or legal guardian can understand the purpose of the study, demonstrate sufficient compliance with the study protocol, and sign the informed consent exclusion criteria: * the target aneurysm has previously received craniotomy clipping or other endovascular interventional treatment * target aneurysms were haemacular aneurysms, pseudoaneurysms, arteriovenous malformations and moyamoya disease related aneurysms * dsa suggested vascular path tortuosity or severe arteriosclerosis, and it was difficult for the instrument to reach the target vessel * contraindications to dual antiplatelet therapy and anticoagulation therapy * patients with known clear allergy to nickel-titanium alloys and platinum-tungsten alloys * people with known severe allergy to contrast media (excluding rash) * patients with known dementia or mental illness * preoperative complicated with serious heart, liver, kidney, respiratory system diseases and bleeding disorders * life expectancy is less than one year * is participating in, or may participate in, any other drug or medical device clinical trial after inclusion in this clinical trial * other conditions determined by the investigator to be unsuitable for participation in this clinical trial
pemetrexed and cisplatin treatment before surgery in non small cell lung cancer

Conditions: Non-Small-Cell Lung Cancer

Summary: to determine the response to this regimen for therapy prior surgery in patients with locally advanced disease or metastatic disease.


Eligibility criteria:
inclusion criteria: * diagnosis of non-small-cell carcinoma of the lung * patients with locally advanced disease or metastatic disease, candidates to surgery after evaluation by oncologist and thoracic surgeon * tumour with possibility of curative surgery * at least one uni-dimensionally measurable lesion * adequate pulmonary function to perform the planned surgical resection exclusion criteria: * active infection (at the investigator's discretion) * pregnancy or breast-feeding * serious concomitant illness at the investigator's discretion * previous diagnosis of malignant disease * they have received treatment during the last 30 days with a drug, other than the study drug, that has not received regulatory approval for any indication at the time of their entry in the study
efficacy and safety of m100907 on sleep maintenance insomnia with a sub-study in stable type ii diabetes mellitus

Conditions: Sleep Initiation and Maintenance Disorders

Summary: the purpose of this study is to assess efficacy and safety of volinanserin in the population of patients complaining of sleep maintenance insomnia. the objective of the substudy is to assess glycemic control in the subgroup of patients with type ii diabetes mellitus.


Eligibility criteria:
inclusion criteria: * diagnosis of primary insomnia based on diagnostic and statistical manual of mental disorders (fourth edition) criteria * disturbances of sleep maintenance criteria based on patient's information related to sleep pattern during the preceding month sub-study : * patients will be included if they have an established medical diagnosis of type ii diabetes mellitus, and have been treated either with an oral hypoglycemic agent and/or insulin for at least three months prior to the screening visit (with stable regimen for at least one month prior to screening) exclusion criteria: * females who are lactating or who are pregnant * night shift workers, and individuals who nap 3 or more times per week over the preceding month * consumption of xanthine-containing beverages (i.e. tea, coffee, cola) comprising more than 5 cups/day * participation in another trial having received study medication within 1 month before the screening visit * body mass index ≥ 33 * use of over-the-counter medications such as tryptophan, valerian root, kava, melatonin, st. john's wort, alluna or prescription sleep medication * use of any substance with psychotropic effects or properties know to affect sleep/wake * history of primary hypersomnia, narcolepsy, breathing-related sleep disorder, circadian rhythm sleep disorder, parasomnia, dyssomnia * clinically significant, severe or unstable, acute or chronically progressive medical or surgical disorder * positive qualitative urine drug screen (opiates, cocaine, amphetamine...) the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: sleep problems insomnia sleeplessness primary insomnia insomnia disorder
influence of positive-end-expiratory-pressure (peep) on cardiac output in mechanically ventilated children

Conditions: Ventilation Therapy; Complications; Congenital Heart Disease; Children, Only; Hemodynamic Instability

Summary: interventional trial to determine the effect of different peep levels on cardiac output and right-ventricular function in mechanically ventilated children \< 5 years of age with congenital heart disease.

different peep-levels will be applied during invasive mechanical ventilation to describe cardio-pulmonary interactions in children with congenital heart disease (chd). an additional trial with the same study protocol is planned in a cohort of children with primarily pulmonary disease without chd after completion of this trial. esophageal pressure-monitoring, ultrasound, respiratory mechanics and electrical impedance tomography will be used

Eligibility criteria:
inclusion criteria: * invasive mechanical ventilation * congenital heart disease (biventricular anatomy) exclusion criteria: * univentricular hearts * ecmo/vad
does low-dose aspirin improve outcome in in vitro fertilisation/intra cytoplasmatic sperm injection (ivf/icsi)?

Conditions: Infertility

Summary: to investigate the effect of daily administration of low-dose aspirin, compared to placebo, on ivf and icsi outcome.


Eligibility criteria:
inclusion criteria: * dutch-speaking women * starting a first or second ivf/icsi cycle exclusion criteria: * women suffering from * platelet dysfunction * thrombopenia * gastro-intestinal ulcers * recurrent gastritis * aspirin hypersensitivity * women on treatment with anticoagulants or aspirin

Keywords: ivf and icsi
effect of aerobic exercise on side effects of disease modifying therapy with subcutaneous interferon-b1b in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to investigate the effects and tolerability of exercise on side effects of injectable disease modifying treatments in multiple sclerosis. the investigators main hypothesis is that controlled exercise is safe and can be well tolerated in patients with multiple sclerosis and it can improve disease modifying treatment related side effects such as fatigue.

patient compliance with disease modifying treatment largely depends on relatively common side effects of such treatments such as fatigue. regular exercise can potentially improve these side effects. however, safety and effects of exercise has not been studied in patients with multiple sclerosis. our main aim is to study the safety, tolerability and effects of exercise on side effects of subcutaneous interferon-b1b in patients with multiple sclerosis.

Eligibility criteria:
inclusion criteria: * recent diagnosis of relapsing remitting multiple sclerosis on treatment with b1b-interferon disease modifying treatment

Keywords: multiple sclerosis b1b-interferon fatigue exercise
demonstrating the efficacy of a spanish-language program for latino dementia caregivers

Conditions: Caregiver Burden of People With Dementia

Summary: the investigators will test the efficacy of unidos en el cuidado® (united in caring, herein unidos), a 3-session, culturally-adapted, group psychoeducational and skill-building intervention for 226 spanish-speaking family caregivers in california.

the investigators will test the efficacy of unidos en el cuidado® (united in caring, herein unidos), a 3-session, culturally-adapted, group psychoeducational and skill-building intervention for 226 spanish-speaking family caregivers in california. based on a wait list trial design, and 4 observation points (baseline, post-intervention, 3-month and 6-month follow-ups), the investigators propose to demonstrate the efficacy of this new intervention (aim 1), and evaluate for potential moderating conditions across subgroups (aim 2; age, gender, educational level, etc.). based on this quantitative component, the investigators will answer the following two aims: aim #1. (efficacy) compared to a waitlist control group, is unidos efficacious with regards to primary outcomes-phq-9 depression symptoms, rmbpc reactivity to memory and behavior problems, anxiety symptoms, and secondary outcomes-caregiver mastery, competence, and meaning over time? aim #2: (moderators). do moderating conditions exist such that the intervention is more or less efficacious for subgroups based on age, gender, plwd functioning? qualitative component: after class completion, the investigators will draw from 40-50 focus group participants to elucidate the satisfaction and acceptability of the program. both unidos and wait list control participants will be randomly selected for focus group interviews which will be guided by open-ended inquiries around the nuanced, in-depth perspectives of program participation, acceptability, and recommendations (aim 3). aim #3: (experience/satisfaction). will qualitative reports from focus groups signal satisfaction, nuanced differences with respect to the nature, structure, cultural/ language considerations of unidos, and recommendations? based on the scientific team and community partner's established expertise in dementia care, caregiving services, and underrepresented groups, the project is well positioned to address the linguistic and cultural preferences and needs of diverse californians and the providers that serve them.

Eligibility criteria:
inclusion criteria: * identifies with being hispanic or latino descent * speaks and reads spanish * dementia family caregivers living (or recently lived) in california or whose care recipient lives (or recently lived) in california * who identify as women, men, or non-binary, * age 18 years or older exclusion criteria: * severe sensory or physical conditions that interfere with ongoing participation.

Keywords: wait list control interventional study
app-based psychosocial intervention to enhance quality of life in arabic-speaking refugees residing in switzerland

Conditions: Quality of Life; Stigma, Social; Depression; PTSD; Anxiety

Summary: the ongoing warfare and economic instability in the middle east and in north africa causes many people to leave their home countries. arrived in a host countries, in this example, in switzerland, they face a lot of structural and psychosocial hurdles. particularly in the first years, building up a certain quality of life is complicated and challenging. to support this process, the swiss red cross and the university of bern have developed the sui app. it contains structural and social information as well as low-intensity psychological tools to provide support to the everyday life of arabic-speaking people in switzerland.


Eligibility criteria:
inclusion criteria: * at least 18 years old * arabic as native or second language * good knowledge of reading, writing and speaking arabic * have lived in switzerland for no longer than 5 years * give written consent * have access to a smartphone and an internet connection * indicate an emergency contact whom they could contact in event of a crisis exclusion criteria: * indicate an increased risk of self-harm or suicide at baseline * indicate having been diagnosed with psychosis or bipolar disorder * be participating in a similar study at baseline * have a lack of written and spoken arabic skills
coronary computed tomographic angiography in intermediate-risk chest pain patients

Conditions: Chest Pain; Acute Coronary Syndrome; Coronary Artery Disease

Summary: the aim is to determine whether a diagnostic strategy including early coronary computed tomographic angiography in intermediate-risk patients presenting to the emergency department with chest pain reduces the composite endpoint of death, readmission because of myocardial infarction or unstable angina requiring revascularization.

patients presenting to the ed with chest pain or other symptoms suggestive of acs, without acute mi but with an intermediate risk (heart-score \>3) will after written informed consent be randomized to either a strategy with an initial ccta or not. patients randomized to strategy including early ccta will receive standard care according to responsible physician and perform a ccta as soon as possible (in most cases within 24 hours, but at least within 21 days).the result will be presented to the responsible physician who will plan further care of the patients. patients randomized to a strategy not including early ccta will receive further care (including examinations) according to responsible physician but not include early ccta. these patients will often undergo a non-invasive functional test, such as exercise-ecg, stress echocardiography or nuclear imaging according to local routines, but not always. all patients should receive optimal prevention according to current guidelines. the responsible physician will be encouraged to initiate secondary prevention measures if examinations show signs of cad. the primary endpoint is composite of death, readmission because of mi or unstable angina requiring revascularization.

Eligibility criteria:
inclusion criteria: 1. age≥18 years. 2. within 24 hours from presenting to the ed with chest pain or other symptoms suggestive of coronary artery disease (cad) 3. heart-score \>3 (according to http://www.heartscore.nl/) 4. written informed consent obtained exclusion criteria: 1. any condition that may influence the patient's ability to comply with study protocol. 2. acute mi 3. known obstructive cad (\>50%) or previous pci or cabg. 4. clear alternative diagnosis 5. estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73m2 6. major allergy to iodinated contrast media 7. circumstances making high quality images unlikely. 8. not a swedish resident with a personal id-number. 9. pregnancy or breast feeding 10. further investigation for cad not indicated, due to limited life expectancy, quality of life or functional status 11. previous inclusion in the trial
nutritional status and patient characteristics upon length of stay, clinical outcome, and survival in older hospitalized patients

Conditions: Geriatric; Malnutrition; Length of Stay

Summary: disease-related malnutrition (drm) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. nutritional status plays a vital role in the fate of hospitalized patients, and drm is associated with loss of function and decreased survival. drm is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. in addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of drm in older acutely admitted patients still needs to be understood. this project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. in relation, the study will investigate the relation between patient characteristics and disease progression. the obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.


Eligibility criteria:
inclusion criteria: * acutely admitted adults aged 65 years and above. * be able to comply with the study information, as assessed by the research personnel. * be able to understand danish. exclusion criteria: * \<24 hours admission * terminal illness in end stage of life * patients with temporary civil person registration number (cpr)

Keywords: geriatric disease-related malnutrition physiology acute illness deep phenotyping nutritional status
impact of dyspnea, regional lung ventilation, and diaphragmatic function during de novo acute respiratory failure

Conditions: Acute Respiratory Failure

Summary: modern management of acute respiratory failure aims to relieve dyspnea and anxiety by providing a non-invasive respiratory support. this approach tries to avoid endotracheal intubation, patient self inflicted lung injuries (psili) and diaphragmatic dysfunction. the present study aims to evaluate dyspnea, pulmonary regional ventilation and diaphragmatic function in patients with hypoxemic acute respiratory failure by different observations, and to bring risk factor for intubation out.

patients aged of 18 years or more, presenting with an acute respiratory failure without hypercapnia will be included in the study. clinical and biological variables, dyspnea assessment, regional lung ventilation (electrical impedance tomography) and diaphragm function (ultrasound) will be evaluated at inclusion and at 2 hours, 4 hours and 48 hours after inclusion. in case of intubation, diaphragmatic function will be also evaluated with phrenic nerve stimulation technique. primary endpoint is intubation at day 7. secondary endpoints are measurement of dyspnea, pulmonary ventilation and diaphragmatic function, also ventilator free days, icu length of stay and mortality.

Eligibility criteria:
inclusion criteria: * age \> 18 * acute respiratory insufficiency defined by the three following items : 1. pao2/ fio2 \<300 2. respiratory rate \> 25/min 3. oxygen support \> 10l/min or high flow nasal oxygen (hfno) * non opposition by the patient to be included * social insurance exclusion criteria: * respiratory acidosis (ph \ 45mmhg or 6kpa) * chronic respiratory disease ( copd, bronchiectasis...) * cardiogenic acute lung oedema * non intubation decision at randomisation * contraindication for electro-impedance tomography-belt placement (chest trauma with rib fractures, thoracic wound, chest tube). * uncommunicative patient (glasgow coma scale \<12) * guardianship or curators for vulnerable patients.

Keywords: acute respiratory failure diaphragm dyspnea eit
clinical outcomes of percutaneous nephrolithotomy following retrograde percutaneous nephrostomy access using novel device in comparison to antegrade access

Conditions: Kidney Stone

Summary: the purpose of this study is to compare relevant clinical outcomes in patients requiring percutaneous nephrostomy for urolithiasis treatment between those who undergo an antegrade approach versus a retrograde approach and to determine which clinical characteristics predict success of lithotomy with anterograde or retrograde percutaneous nephrostomy approaches.


Eligibility criteria:
inclusion criteria: -renal pelvis and proximal ureteral stones \>10 mm confirmed with non-contrast computed tomography exclusion criteria: * suspected pyelonephritis. * prior percutaneous nephrolithotomy procedure in affected kidney. * mid-ureteral or distal ureteral stones. * pregnancy. * anatomical abnormal kidney, including: * horseshoe * ectopic

Keywords: nephrostomy
hip fractures in chile: implications for public health policy and healthcare delivery

Conditions: Hip Fractures

Summary: hip fractures in individuals aged 60 and above pose significant challenges in terms of morbidity, mortality, and healthcare costs. while countries like the united kingdom and australia have optimized their healthcare systems for timely management of hip fractures, the situation in chile presents distinct challenges due to its mixed healthcare system. this study aims to assess survival rates following hip fractures in chile and identify associated risk factors using national databases from 2012 to 2018. a comprehensive analysis of 35,520 patients revealed that factors such as age, type of health insurance, access to surgery, and treatment in public hospitals significantly influence mortality rates after hip fractures. the study found that patients with hip fractures experience lower 5-year survival rates compared to the general population, particularly when affiliated with public insurance and treated in public institutions. modifiable factors like delayed surgery and prolonged hospital stays contribute to increased mortality rates. the findings underscore the urgent need for optimized public health policies and healthcare delivery systems to enhance outcomes for hip fracture patients in chile.hip fractures in individuals aged 60 and above pose significant challenges in terms of morbidity, mortality, and healthcare costs. while countries like the united kingdom and australia have optimized their healthcare systems for timely management of hip fractures, the situation in chile presents distinct challenges due to its mixed healthcare system. this study aims to assess survival rates following hip fractures in chile and identify associated risk factors using national databases from 2012 to 2018.


Eligibility criteria:
inclusion criteria: all patients in the national database between 2012 and 2017 which his principal was hip fracture. diagnoses are classified using the international classification of diseases, 10th revision (icd-10) codes. a search was conducted for codes s72.0 (head and neck fracture of the femur), s72.1 (pertrochanteric fracture), and s72.2 (subtrochanteric fracture of the femur). exclusion criteria: missing ids id with inconsistent socio-demographic information. patients with primary diagnosis of hip fracture that underwent surgery but the national code surgery was not one of the following: : 2104128, 2104129, 2104131, 2104132, 2104135, 2104228, 2104229 and 2104231