Kornimate/medical-research-clean huggingface dataset:
assessment of nutritional status in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: the main theme of the cohort of systemic sclerosis (ssc) patients is the determination of nutritional status, its evolution and the evaluation of its management in patients with scleroderma. the main objectives are : * to determine the incidence of malnutrition and its main determinants (disease characteristics, severity, eating habits, physical activity) in patients with scleroderma. * for patients with undernutrition at inclusion or at 18 months follow-up: evaluate the impact of a standardized nutritional intervention (dietary advice, oral supplements, artificial, enteral or parenteral nutrition) on nutritional and disease parameters. follow-up visits will take place every 6 months for 2 years. (m6, m12, m18 et m24). during each visit: a clinical examination, with anthropometric measurements, a 3-day dietary survey and a blood sample (10 ml), completion a multiple-choice of quality of life and physical activity evaluation. paraclinical evaluation : echocardiography, lung function tests, screening for osteoporosis (m6 and m18). if undernutrition is detected during a follow-up visit, the subject will be referred to a specialized service.


Eligibility criteria:
inclusion criteria: * all ssc patients aged 18 or more * patient followed at the montpellier university hospital * patients must fulfil the american college of rheumatology (acr) and european league against rheumatism (eular) 2013 criteria for ssc. * health insurance (affiliation to social security) * collection of non-opposition to participate in the study exclusion criteria: * patient under the protection of justice curatorship / guardianship; * patients who have already planned to move out of the region in the next two years, making the follow-up impossible.
water and the gastropressor response - tachyphylaxis

Conditions: Orthostatic Hypotension

Summary: we are studying the effects of oral water ingestion in patients with orthostatic hypotension. in this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

we are studying the effects of oral water ingestion in patients with orthostatic hypotension. this has been termed the gastropressor response. in this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. in this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. on the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Eligibility criteria:
inclusion criteria: * orthostatic hypotension (fall in bp\>20/10 mmhg) * pressor response to water in other studies * age 18-80 years exclusion criteria: * pregnancy

Keywords: water orthostatic hypotension blood pressure
fluorescence angiography in the assessment of diep flap perfusion

Conditions: Breast Cancer; Vascularization; Fat Necrosis

Summary: it is a single-center, prospective, randomized and controlled study focused in microsurgical autologous breast reconstruction. it involves applying indocyanine green (icg) angiography for the study of the vascularization of diep flaps. the aim of the study is to determine whether there are differences in complications and aesthetic results when icg is used to discard the poorly vascularized areas of the flap. the study includes adult women undergoing unilateral diep flap breast reconstruction. the calculated sample size is 60 patients. there are two groups. in group 1, the investigators use the usual clinical criteria to discard the poorly vascularized areas of the flap. in group 2, the investigators use the icg to shape the flap.


Eligibility criteria:
inclusion criteria: * mastectomized adult female patient * abdominal flap unilateral breast reconstruction indication * alloplastic breast reconstruction sequelae * enough amount of abdominal dermofat tissue to shape a breast with a primary closure of the donor site exclusion criteria: * diep flap bilateral breast reconstruction indication * previous abdominoplasty surgery * untreated psychiatric disease * untreated infection * indocyanine green or iodine hypersensitivity * hyperthyroidism, thyroid adenoma or thyroid autonomy * any concomitant disease or condition that, in the opinion of the investigator, can make the patient unsuitable to receive a microsurgical technique or to join the research.
cook ivc filter study

Conditions: Pulmonary Embolism

Summary: this prospective, multicenter, double-arm clinical study further evaluated the safety and effectiveness of cook's commercially available inferior vena cava (ivc) filters (specifically, the günther tulip® vena cava filter and cook celect® vena cava filters) in patients in need of temporary or permanent ivc filter placement for the prevention of pulmonary embolism (pe).


Eligibility criteria:
inclusion criteria: * requires temporary or permanent ivc filter placement for the prevention of pe exclusion criteria: * less than 18 years of age * known hypersensitivity or contraindication to contrast medium that cannot be adequately premedicated * known allergy or sensitivity to cobalt, chromium, or nickel * pregnant or planning to become pregnant in the next 12 months * patient refuses blood transfusions * at risk of septic embolism * medical condition or disorder that would limit life expectancy to less than 12 months or that may cause noncompliance with the protocol or confound the data analysis * existing ivc filter * duplicate ivc * anatomy that would prevent safe filter placement (e.g., condition of access vessels) * ivc diameter \> 30 mm or \< 15 mm

Keywords: venous thrombosis pulmonary embolism vena cava, inferior vena cava filters venous thromboembolism
theater in school sex education - a randomized controlled study

Conditions: Attitude; Sexual Behavior; Condom Use; Prevention; Chlamydia Infections; Safe Sex

Summary: the study evaluated if interactive theater in school sex education affects student knowledge, attitudes and behavior regarding condom use. the intervention group got a play, value exercises, chlamydia games, condom school and interactive replay with professional actors and staff from a youth guidance center. the control group got standard sex education from school staff, based on the education guidelines of the swedish national agency for education.

the spread of chlamydia indicates that current preventive work with condoms is insufficient. research shows that reasons behind increased chlamydia include youths taking more sexual risks, due to altered attitudes and sexual behaviors. since only condoms protect against both sexually transmitted infections (stis) and unwanted pregnancy, the goal of the world health organization (who) chlamydia prevention program is to increase condom use. research suggests that school is the most important arena for sex education, reaching all youths early in life, when many values on sex and relationships are instilled. international studies on theater in sex education indicate effects like increased knowledge on the topic, and partially changed attitudes and behaviors among youths. furthermore, several studies show that youths feel theater is a good method for sex education and a supplement to standard education.

Eligibility criteria:
inclusion criteria: * students in eighth grade * could read and understand swedish exclusion criteria: * students in special education.

Keywords: chlamydia infections condoms theater, sex education
the effect of weight bearing on patient outcomes following 1st mtp joint fusion

Conditions: Hallux Valgus; Hallux Rigidus

Summary: randomized-controlled trial looking specifically at the effect of weight bearing on the outcomes of first mtp joint fusions

the objective of this prospective, randomized controlled trial is to determine if there are any adverse outcomes associated with immediate weight bearing as compared to non-weight bearing following first mtp joint fusion. the primary outcome measures will look at patient reported outcomes of pain and function. the secondary outcome measures will be the difference in the incidence of non-union, as well as adverse events/complications (malunion, wound complications, hardware complications, infection, stress fracture).

Eligibility criteria:
inclusion criteria: * age 18 years or great * medically fit for surgery * patients diagnosed with condition for which a 1st mtp joint fusion is a surgical management option based on clinical examination and radiographs * failed non-operative management (orthotics, bracing, tylenol, nsaids, shoe-wear modification) * surgery is for an isolated 1st mtp fusion * able and willing to comply with follow up schedule and requirements * capable of providing informed consent exclusion criteria: * age \<18 years old * surgical booking is for more than just 1st mtp fusion * unable to comply with follow up schedule and requirements * unable to provide informed consent

Keywords: mtp hallux rigidus osteoarthritis
pudendal nerve mapping towards improved neuromodulation for urinary retention

Conditions: Urinary Retention; Underactive Bladder

Summary: this study is to map the pudendal nerve. in this study the researchers will examine subjects who are already receiving an implanted stimulator at their pudendal nerve as part of their normal clinical care.

the pudendal nerve goes to the urethra, anus, and other areas of the pelvic floor. electrical stimulation of this nerve can help with bladder problems and pelvic pain. researchers do not understand how the nerve anatomy is different between people. successfully mapping the pudendal nerve may help improve the medical care for future patients with bladder problems, pelvic pain, bowel problems, and sexual problems.

Eligibility criteria:
inclusion criteria: * clinically referred as having bladder problems that have not responded to conservative treatment. normal clinical care includes referral to implant of medtronic interstim neurostimulator at the pudendal nerve. fully eligible to receive an interstim implant. * adult (18 or older), capable of providing own informed consent and communicating clearly with research team * capable of speaking, reading, and understanding english, as all study questionnaires are standardized assessments only available in english * capable of attending all experimental sessions (visit 1: pre-stage-1 imaging, visit 2: stage-1 surgery, visit 3: ct after stage-2 surgery, visit 3: cystometrogram test) exclusion * implanted materials that prohibit magnetic imaging * any medical problems that prevent an individual from laying flat in an mri or ct scanner, are are claustrophobic. * areflexive or atonic bladder * pregnant or planning to become pregnant. if a woman of child-bearing potential wishes to participate in this study, they will be pre-screened with a test to detect pregnancy. * diagnosed neurogenic bladder, pudendal nerve damage, lower motor dysfunction, or other conditions that would affect the neural circuits involved in micturition. * unwilling to allow de-identified data to be stored for future use or shared with other researchers.

Keywords: pudendal nerve mapping
extra sitting time after spinal anesthesia for cesarean section and fetal well-being

Conditions: Complications; Cesarean Section; Hypotension

Summary: after injection of the spinal anesthetic drug, women will be allowed to lie down immediately (0-30 sec) or after three minutes (180 sec) of sitting. the incidence of maternal hypotension and fetal umbilical cord blood ph will be recorded.


Eligibility criteria:
inclusion criteria: * women with elective cesarean delivery at 39-42 wks gestation. exclusion criteria: * women who shorter than 5'0" in height, those with primary or pregnancy-induced hypertension, macrosomia, multiple gestation will be excluded. * women with known risks of bleeding or potential hysterectomy such as those with placenta previa or accrete will also be excluded. * if the epidural catheter cannot be placed within the specific time frame after the spinal injection, the case will be excluded.
clinical and genetic influencing factors on clozapine pharmacokinetics

Conditions: CYP1A2 Polymorphism; CYP2C19 Polymorphism; Clozapine; Schizophrenia

Summary: clozapine (clz), an atypical antipsychotic, is the reference medication for patients with treatment-resistant schizophrenia. due to the high inter-individual variability of its pharmacokinetics and its narrow therapeutic index, a close therapeutic drug monitoring (tdm) of clz is highly recommended. several factors can cause a variation in the pharmacokinetics as age, smoking habits, coffee consumption and drug interaction. genetic factors related to hepatic expression levels of the cytochrome p450 (cyp), regulate the hepatic clearance of clz, thereby determine its bioavailability. the cyp1a2 and cyp2c19 isoenzymes are mainly responsible for the metabolism of several drugs including clz. it has been demonstrated that there is an interethnic variation in the expression and function of these two isoenzymes. this variation is caused by single nucleotide polymorphisms (snps) of genes encoding these proteins. while the influence of the different polymorphisms related to cyp1a2 and cyp2c19 have been established especially in asian and caucasian populations, no study has examined the impact of these snps in the southern mediterranean populations. moreover, the impact of these snps is very controversial. the present study aims to investigate in tunisian schizophrenic patients, the influence of genetic (cyp1a2 and cyp2c19 polymorphisms) and non-genetic factors on clz pharmacokinetics.


Eligibility criteria:
inclusion criteria: * schizophrenic patients receiving clozapine * good adherence to the treatment (clozapine) exclusion criteria: * patients who were co-prescribed drugs that affected the pharmacokinetics of clozapine. * patients who presented gastrointestinal disorders disturbing absorption of clozapine.
n10: a study of reduced chemotherapy and monoclonal antibody (mab)-based therapy in children with neuroblastoma

Conditions: High-risk Neuroblastoma; Neuroblastoma; Childhood Neuroblastoma

Summary: the purpose of this study is to find out whether n10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.


Eligibility criteria:
inclusion criteria: * diagnosis of nb as defined by histopathology, bm metastases plus high urine catecholamine levels, or positivity in mibg scan. * hr-nb, defined as mycn-amplified stage l2/m/ms at any age and stage m in patients \>18 months old. * no more than one prior cycle of hr-nb chemotherapy * age \<19 years. * signed informed consent indicating awareness of the investigational nature of this treatment. exclusion criteria: * severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity \> grade 2 * inability to comply with protocol requirements * pregnancy

Keywords: high-risk neuroblastoma neuroblastoma childhood neuroblastoma n10 memorial sloan kettering cancer center 24-144
bone health in hyperemesis gravidarum

Conditions: Hyperemesis Gravidarum

Summary: the purpose of the study is to determine whether maternal bone resorption would be seen in hyperemesis gravidarum and could be detected in early period using serum vitamin d levels, serum calcium (ca) levels, serum parathormone (pth) levels and urine n- telopeptide levels in the patients with hyperemesis gravidarum.


Eligibility criteria:
inclusion criteria: * between 7. and 20. weeks of gestation pregnant women in both groups * i̇n hyperemesis group; 5% weight loss with regard to pre-gestation vomiting more than 3 times 3-5 % weight loss with ketonuria. exclusion criteria: * other pathologies that cause nausea and vomiting in pregnancy gastroenteritis gastroparesis gall duct diseases hepatitis peptic ulcers appendicitis pyelonephritis ovarian torsion urinary tract stones diabetic ketoacidosis hyperthyroidism hyperparathyroidism migraine pseudo tumor cerebra vestibular diseases * additionally some situations causing to rise of ntx levels osteoporosis paget disease bone tumors * furthermore some of conditions resulted in pre-menopausal osteoporosis or decreasing in bone mineral density malignancy smoking celiac disease depression inflammatory bowel disease pre-gestational diabetes chronic kidney or liver disease drug use such as steroids, anticonvulsants, antiepileptic, heparin or low molecular weight heparin

Keywords: hyperemesis gravidarum bone health urine n-telopeptide serum calcium serum parathormone serum vit d
study of chinese newly diagnosed participants with philadelphia chromosome-positive (ph+) chronic myeloid leukemia in chronic phase (cml-cp)

Conditions: Chronic Myeloid Leukemia; Philadelphia Chromosome; Chronic Myeloid Leukemia in Chronic Phase

Summary: observational medical record review of newly diagnosed cml-cp participants in china


Eligibility criteria:
inclusion criteria: * ph+ cml-cp patients who were diagnosed between august 1, 2014 to august 1, 2016 * 18 years or older at time of diagnosis exclusion criteria: * participants once enrolled in any interventional clinical trial for cml * participants whose records are not available other protocol defined inclusion/exclusion criteria could apply
the valid of gfr in chronic kidney disease patients

Conditions: Chronic Kidney Disease

Summary: study was cancel due to principle investigator had been resigned

study was cancel due to principle investigator had been resigned

Eligibility criteria:
inclusion criteria: * age more than 16 exclusion criteria: * none

Keywords: gfr ckd
anti-ageing efficacy of a cosmetic formulation containing nmn (2%) versus placebo

Conditions: Wrinkle; Fatigue; Puffiness Around the Eyes

Summary: the study aims at evaluating skin wrinkling, puffiness and fatigue and dark circle appearance on asian and african-american healthy volunteer cohorts receiving a cosmetic formulation containing nmn (2%). the product will be evaluated after 28 and 56 days of twice-daily application in comparison with a reference cosmetic formulation using clinical scoring under dermatological control. cosmetic acceptability and future use will also be subjectively evaluated by analysis of the subjects answers to an evaluation questionnaire.


Eligibility criteria:
inclusion criteria: * healthy subject * subject having given her free informed, written consent * subject willing to adhere to the protocol and study procedures * subject with normal frontal temperature lower than 37.5°c/100.4°f * subject has read and understood the information given by the investigator related to protection against novel coronavirus 19 and necessity to contact the investigator in case of any suspicion of covid related manifestation (increase of frontal temperature, cough, sore muscles, weakness...) during the study exclusion criteria: * pregnant or nursing woman or woman planning to get pregnant during the study * start, stop or change in hormonal treatment (including contraceptive pill) \<1.5 months * cutaneous pathology on the study zone (face) * use of topical or systemic treatment during the previous weeks liable to interfere with the assessment of the cutaneous efficacy of the study product * subject having undergone a surgery under general anesthesia within the previous month * know allergy to certain cosmetic or dermato-pharmaceutic products * subject having done injections on face and/or a lifting * excessive exposure to sunlight or uv-rays within the month preceding the study

Keywords: skin aging
impact of ventricular pacing in unselected icd/crt-d patients

Conditions: Ventricular Tachycardia; Ventricular Fibrillation

Summary: observational study is evaluating ventricular tachycardia (vt)/ventricular fibrillation (vf) thérapies as a function of ventricular pacing

this protocol consists in a non-interventional multi-centre, prospective study. the observational study will also answer the question of the impact of ventricular pacing on the outcome of patients implanted with icd \& crt-d devices and how the icd \& crt-d devices are used in clinical practice through two years follow-up.

Eligibility criteria:
main inclusion criteria: •patient implanted (primo implantation or replacement) with an icd (ovatio vr 6250, dr 6550, crt 6750 models, or any similar or higher range device, that includes specific diagnostic and therapeutic functionalities, mandatory to make homogeneous the collection of data) main exclusion criteria: * presence of a contra-indication to the icd therapy. * life expectancy less than 12 months.

Keywords: impact of ventricular pacing on the incidence of vt/vf episodes for each models
the construction of bidirectional column study of acute osteoporotic vertebral compression fractures

Conditions: Osteoporosis Fracture

Summary: our research group plans to establish a disease specific bidirectional cohort study on prognosis prediction of acute osteoporotic vertebral compression fracture based on imaging and clinical data, and to establish a comprehensive bioinformation database on ovcfs, including patient status, clinical data, laboratory examination, and imaging examination database


Eligibility criteria:
inclusion criteria: all patients who suffer a acute osteoporosis vertebral compression fractures - exclusion criteria: those who have endocrine disease which have impacts on the bone density -

Keywords: osteoporosis fracture