Kornimate/medical-research-clean huggingface dataset:
risk factors for predictors of maces after ra-cabg

Conditions: Coronary Artery Disease

Summary: as the secondary choice of artery grafts, radial artery is more and more used to achieve multiple arterial revascularization in cabg. risk factors for predictors of major cardiovascular adverse events (mace) after cabg using radial-artery grafts (ra-cabg), however, remain uncertain. this case-control study aims to identify the baseline predictors of mace after ra-cabg. we will collect the baseline characteristics and perioperative data of patients underwent ra-cabg from jan. 2009 to dec. 2019 in our single center. by reviewing the latest follow-up records, we will examine the correlation between the baseline characteristics and clinical outcomes (maces), then identify the independent risk factors for predictors of maces after ra-cabg.


Eligibility criteria:
inclusion criteria: * underwent cabg using at least a radial artery grafts from jan.2009 to dec.2019. with or without cardiopulmonary bypass , with or without concomitant procedure * aged 18 and above at procedure * with any gender exclusion criteria: * with unavailable medical records

Keywords: risk factors cabg radial artery mace
dash diet in heart failure outpatients

Conditions: Heart Failure

Summary: the purpose of this study is to refine the classification of the effectiveness of the dash diet for outpatient heart failure (hf) management, using behavioral, clinical, and laboratory correlative science approaches.

the overall objective of this pilot study is to refine the classification of the effectiveness of the dash diet for outpatient hf management using behavioral, clinical, and laboratory correlative science approaches. the investigators will integrate the use and evaluation of dash diet nutrition education in a clinical population using a pragmatic study approach. the investigators will assess dietary behavior change. the investigators will assess the medical effectiveness of the dash diet to improve patient symptomology and clinical biomarkers. exploratory investigations will involve metabolomics analyses of plasma samples for biomarker discovery of clinical phenotypes in hf patients, to characterize metabolic profiles related to dietary exposure.

Eligibility criteria:
inclusion criteria: * heart failure diagnosis * guideline directed medical therapy optimization on stable regimen at least 30 days exclusion criteria: * bmi \< 18/5 kg/m squared * cardiac cachexia * end-stage renal disease or dialysis * acute inflammatory condition * uncontrolled arrhythmias or ischemia * status post heart transplant or implanted left ventricular assist device
the effect of continuous, various doses of furosemide drip on hearing as measured by acoustic emission

Conditions: Hearing Status

Summary: pediatric patients, during their illness often treated with furosemide (lasix) continuous drip, often, with dosages above 4-6mg/kg/day (the recommended dose). this study will monitor hearing status of these children prior to their therapy with furosemide, during this therapy and after.

this study will record hearing status, by acoustic emission, of critically ill children, treated with different dosages of furosemide drip. acoustic emission test will be done prior to therapy and q48 hours during their course of treatment with furosemide drip. dosage of furosemide drip, boluses and other relevant medications (i.e - vancomycin, muscular relaxants, aminoglycosides etc) will be recorded.

Eligibility criteria:
inclusion criteria: * all children admitted to pediatric icu who are treated with furosemide continuous drip. exclusion criteria: * children with known hearing abnormalities prior to treatment.

Keywords: children critically ill furosemide acoustic emission
adjunctive right atrial ablation for persistent atrial fibrillation with right atrial enlargement

Conditions: Persistent Atrial Fibrillation; Right Atrial Enlargement

Summary: this is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.

this is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive ra ablation. we enrolled 65 patients with persistent atrial fibrillation and right atrial enlargement received adjunctive right atrial ablation. these patients were 1:2 match with 130 patients received left atrial ablation only. atrial fibrillation recurrence rate and other paremeters were analyzed to evaluate the efficacy of adjunctive right atrial ablation in this subset of patients.

Eligibility criteria:
inclusion criteria: 1. aged 18 to 80 years old; 2. persistent af with right atrial enlargement; 3. nonresponse or intolerance to ≥1 antiarrhythmic drug. exclusion criteria: 1. history of catheter ablation; 2. valvular heart disease; 3. hypertrophic cardiomyopathy or dilated cardiomyopathy; 4. without follow-up data

Keywords: atrial fibrillation right atrium
comparing the impact of virtual reality and paper and pencil on psychosocial rehabilitation

Conditions: Psychiatric Disease

Summary: virtual reality allows the integration of cognitive rehabilitation in a more ecologically valid context. the purpose of this study is to determine whether this methodology has more impact on psychosocial rehabilitation than a paper and pencil personalized program.

cognitive impairments are frequently present on many psychiatric diseases, such as schizophrenia, depression, etc. and are not always given sufficient attention despite its limitations in activities of daily living (adl's). current cognitive rehabilitation methods mostly rely on paper-and-pencil tasks targeting isolated domains, which is not consistent with everyday life, and have limited ecological validity. virtual reality (vr) has shown to be a solution for the development of accessible and ecologically valid systems but, does it have more impact than a paper and pencil personalized intervention? through a participatory design approach, with health professionals, the investigators have developed: a motor-accessible and cognitive-personalized vr-based system, where conventional cognitive tasks were operationalized in meaningful simulations of adl's (reh@city) and; a web tool which generates personalized paper and pencil tasks (task generator). the investigators goal is to have a sample of 30 inpatients from a psychosocial rehabilitation unit, with no age limit, randomly allocated in two groups: 1) the experimental group, where participants will perform 30 minutes of the vr training with reh@city; and 2) the control group, where participants will perform 30 minutes of the paper and pencil training with the task generator.

Eligibility criteria:
inclusion criteria: * inpatients of psychosocial rehabilitation unit; * cognitive deficit but with enough capacity to understand the task and follow instructions; * able to read and write. exclusion criteria: * patients experiencing an acute psychiatric episode.

Keywords: virtual reality cognitive rehabilitation psychosocial rehabilitation ecological validity personalization
recording of intraoperative spinal cord stimulation and monitoring

Conditions: Cervical Stenosis; Disk, Herniated; Spondylosis

Summary: opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. epidural electrical stimulation (ees) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that ees of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. in this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.


Eligibility criteria:
inclusion criteria: * any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized. exclusion criteria: * none
reducing disparities in living donor transplant among african americans

Conditions: Kidney Transplant

Summary: for most of the patients in the united states with end stage renal disease (esrd), kidney transplantation represents the optimal treatment, and living donor kidney transplantation (ldkt) is preferable. nevertheless, there are pervasive racial disparities in access to ldkt. the main outcome of this study is change in the proportion of study participants who have at least one living donor inquiry by friends/family over study period.the long-term objective is to understand the combined effect of a systems-level intervention (transplant referral exchange or t-rex) and a culturally-sensitive individual-level educational intervention (web-based living acts: about choices in transplantation and sharing) on racial disparities in access to ldkt.

for most of the patients in the united states with end stage renal disease (esrd), kidney transplantation represents the optimal treatment. moreover, living donor kidney transplantation (ldkt) offers numerous advantages such as better kidney quality, increased short- and long-term graft survival, lower rates of acute rejection, and reduced health care cost. nevertheless, there are pervasive racial disparities in access to ldkt, with white esrd patients four times more likely to receive a ldkt than african american esrd patients. the main outcome of this study is change in the proportion of study participants who have at least one living donor inquiry by friends/family over 12 months from baseline.the long-term objective is to understand the combined effect of a systems-level intervention that enhances communication between dialysis facility and transplant center clinicians (transplant referral exchange or t-rex) and a culturally-sensitive individual-level educational intervention (web-based living acts: about choices in transplantation and sharing) on racial disparities in access to ldkt.

Eligibility criteria:
inclusion criteria: * all patients referred (from dialysis facility, chronic kidney disease clinic, or self) and scheduled for an evaluation at one of the four study sites within the study time period. * african american or black * age 18 to 70 years * bmi \< 39 * english-speaking

Keywords: end stage renal disease esrd living donor kidney transplantation ldkt african american
effect of intraoperative fluid restriction on postoperative outcomes in video-assisted thoracic surgery (vats)

Conditions: Acute Lung Injury (ALI); Acure Respiratory Distress Syndrome (ARDS); Sepsis

Summary: the objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g. cardiopulmonary complications, morbidity, mortality and duration of hospitalization) in lung resections via video-assisted thoracic surgery (vats).

working hypothesis and aims: the aim of this study is to investigate the effect of restrictive versus standard intraoperative fluid regimen on cardiopulmonary mordibity and mortality after vats for lung resection. our study hypothesis is that restrictive intraoperative fluid administration in patients undergoing vats, will lead to better outcomes compared to a liberal fluid regimen. methods: after obtaining informed consent, patients will be randomly assigned to one of two groups-liberal-protocol group (lg) or restricted-protocol group (rg). anesthetic and surgical management will be performed similarly and according to standards for both groups, with one exception: patients in the rg group will receive 2 ml/kg•hr whereas patients in the rl group will receive 8 ml/kg•hr of ringer lactate (rl) solution throughout the intraoperative period. hemodynamic changes during this period will be treated pharmacologically unless indicated otherwise. blood loss, in both groups, will be replaced with rl solution in a 3:1 volume replacement, and blood and/or blood products will be transfused when required. postoperatively, pain and fluid management will be standardized for both groups, according to departmental routines. patient assessment will be performed by a blinded assessor. the primary endpoints of the study will combine: the incidence of post-operative complications (pulmonary, cardiovascular, others), re-intubations, and readmitions to the icu during primary hospitalization; number of patients readmitted to the hospital within 30 days of surgery. the secondary endpoints will include length of hospital stay, differences in hematocrit, urea, creatinine concentrations and oxygen saturation immediately postoperatively, in the first and third postoperative days and with discharge, and the number of patients receiving transfusion of blood and blood products; time to extubation, time to sit/stand/walk/eat/drink (recovery data).

Eligibility criteria:
inclusion criteria: * age \> 18 years old, with asa i-iii, undergoing elective vats for lobectomy (of at least 2 segments), segmentectomy or pneumonectomy in the sourasky medical center. exclusion criteria: * patients with a history of chronic renal insufficiency (creatinine \> 1.5 of normal value), congestive heart failure or hepatic dysfunction.

Keywords: fluid management vats ali ards
fearless in neurooncology

Conditions: Primary Malignant Brain Tumor; Glioblastoma (GBM); Astrocytoma; Oligodendroglioma; Caregiver

Summary: the overarching goal of this project is to assess the feasibility, acceptability, and appropriateness of recruitment methods, target population, and a waitlist design to finalize the protocol of fearless in primary malignant brain tumor patients and caregivers

the purpose of this study is to assess the feasibility, acceptability, appropriateness (faa) of recruitment methods, study population, and waitlist design to finalize the protocol of fearless, a psychological intervention targeting fear of cancer recurrence in primary malignant brain tumor patients and caregivers. eligible participants (n=112) will be randomized to either: 1) immediate intervention or 2) delayed treatment control. assessments will take place at baseline, week 12, and week 26.

Eligibility criteria:
inclusion criteria: patients: * self-report a diagnosis of a primary malignant brain tumor (grade ii-iv) * \>2 weeks post-cranial resection or biopsy * elevated fear of recurrence distress rating * primarily english speaking * \>/= 18 years of age at the time of enrollment caregivers: * nonprofessional caregiver to a patient with a primary malignant brain tumor (grade ii-iv) * elevated fear of recurrence distress rating * primarily english speaking * \>/= 18 years of age at the time of enrollment exclusion criteria: patient / caregiver exclusion: * cognitive impairment that might prohibit active intervention engagement * inability to understand and provide informed consent * inability to attend virtual sessions due to unstable or no internet connection

Keywords: brain tumor
reduced-fluence verteporfin photodynamic therapy plus ranibizumab for choroidal neovascularization in pathologic myopia

Conditions: Myopia, Degenerative

Summary: to demonstrate the efficacy of ranibizumab in combination with reduced-fluence verteporfin photodynamic therapy (rf-pdt) in patients with subfoveal choroidal neovascularization secondary to pathologic myopia (pm).

sixty patients received ranibizumab 0.5 mg combined with reduced fluence (rf) verteporfin pdt. ranibizumab was first administered to patients followed after seven days by rf-pdt. subsequently intravitreal ranibizumab (ivr) was injected as needed (pro re nata). all patients were evaluated every 4 weeks for 48 weeks. main outcome measures: mean change in best-corrected visual acuity (bcva) from baseline at 48 weeks, reduced mean central foveal thickness (cft) analyzed by optical coherence tomography (oct) and improved macular sensitivity registered at microperimetry (mp) evaluation.

Eligibility criteria:
inclusion criteria: * pathologic myopia, defined as spherical equivalent greater than 6 d and axial length more than 26 mm (carl zeiss iolmaster v 4.07; carl zeiss meditec, dublin, california, usa); * posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent); * fluorescein angiography (fa) detection of the subfoveal or juxtafoveal cnv (cnv was classified as juxta-foveal if the lesion was closer than 200 mm but not under the geometric center of the foveal avascular zone); * clear ocular media; * duration of symptoms no longer than 4 weeks before enrollment. exclusion criteria: * prior treatment for cnv including previous intravitreal drugs injection or pdt-v; * presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion; * history of recent myocardial infarction or other thromboembolic events; * ongoing uncontrolled hypertension or glaucoma; * refractive media opacities; * eye surgery.
effectiveness of a program of domiciliary exercises against habitual clinical practice in the recurrence of acute low back pain: randomized clinical trial

Conditions: Low Back Pain

Summary: introduction: low back pain is a frequent and universally distributed symptom that affects people of any age and both sexes. approximately 80% of the population will present it at some point in their life. acute low back pain lasts less than 4 weeks, subacute 4 to 12 weeks and chronic more than 12 weeks. hypothesis: treatment with an exercise program combined with the usual treatment decreases the recurrence of acute low back pain, as well as improvements in pain, functionality, and quality of life of patients. principal objective to evaluate the decrease of recurrence of low back pain in the medium-long term of the patients who perform an exercise program compared to those who do not, with both groups receiving the same pharmacological treatment and information of the postural hygiene guidelines endorsed by the current scientific societies. methods: patients between 18 and 65 years of age who come to the emergency room with acute low back pain and who meet the eligibility criteria proposed for this study. at the first visit, patients in a control group and intervention group will be randomized. pharmacological treatment and postural hygiene guidelines will be indicated for both groups, adding the exercise table to the intervention group. the variables chosen are the questionnaires oswestry for functionality, goldberg, euroqol-5d for the quality of life, and vas for pain; which will be measured in the first consultation, at one month, at three and at six months.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years old. 2. low back pain of non-traumatic origin. 3. signature of informed consent. 4. availability for compliance with the intervention and commitment to send the study questionnaires. 5. a correct domain of the spanish language. exclusion criteria: 1. pregnant women and breastfeeding 2. any underlying pathology that contraindicates the use of the drugs (nsaids, paracetamol) included in this study. 3. rheumatological diseases that cause spinal involvement (e.g., spondyloarthritis) 4. low back pain with clinical or associated neurological deficit 5. history of active cancer or remission less than one year 6. pathological previous image test that shows a causal relationship with the episode under study (e.g. fracture-vertebral crush, herniated disc, etc.) 7. low back pain associated with other systemic pathologies (eg urinary infection, retroperitoneal hematomas, pancreatitis, etc.) 8. fever 9. patients with usual analgesic treatment superior to the 1st step of who. 10. major psychiatric pathology diagnosed not stable (pharmacological treatment not stable in the last 6 months) except depression 11. neuromuscular pathology diagnosed 12. having some of the following diseases: fibromyalgia, chronic fatigue syndrome, chronic low back pain diagnosed
comparison for the patient with alzheimer disease the impact of three different groups of patient care

Conditions: Alzheimer Disease

Summary: one of the interests of the alzheimer plan 2008-2010 is to provide increase support to helping families. it's also of major to involve the patient in the most active treatment possible, encouraging social inter relationship as well as cognitive and behavioural stimulation activities. in the frame of non drug related approaches to alzheimer disease (ad), several research projects and actions have already been conducted, but no specific study concerning the efficiency of different types of respite care structures have been conducted so far in france. the present project concerns the thematic of the frame "development and diversification of respite care structures". a platform is defined in the alzheimer plan as a "diversified range of despite structures according to patients' needs and informal caregivers' expectations" providing several objectives: two objectives targeting the informal caregivers: * offer spare time or tutored * inform, support and accompany two objectives targeting the patients: * encourage maintain of the patient social life and relationships and work together towards his/her psychological and emotional well-being * contribute to improve functional cognitive and sensory capacities the study comparse suggests to compare for the patient - informal caregiver couple, the impact of three different groups of patient care on health profit; resit platform (p), the day care group (d), the control group without access to a respite structure (c).


Eligibility criteria:
inclusion criteria * patient affect by alzheimer disease or related pathology * patient with an informal caregiver * patient not using any respite structure * signed informed consent (patient and informal caregiver) * affiliate to social security exclusion criteria * patient without informal caregiver * patient include in another clinical protocol exclusion criteria: -
what the nose knows: hedonic capacity, psychosocial interventions and outcomes in schizophrenia

Conditions: Schizophrenia

Summary: this project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia. the information gathered from the project is of considerable public health relevance, in that, through simple, reliable olfactory assessment, it will provide knowledge about which individuals are most likely to benefit from these psychosocial interventions. such information is crucial for tailoring existing interventions and developing new approaches to optimize outcomes in schizophrenia.


Eligibility criteria:
inclusion criteria: 1. age 18 to 65; 2. dsm-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder exclusion criteria: 1. the presence of a current organic brain syndrome; 2. a current and severe substance use disorder (dsm-5); 3. intellectual disability (dsm-5)

Keywords: olfaction reward