Kornimate/medical-research-clean huggingface dataset:
evaluating treatment efficacy of two syntactic treatment procedures for children with specific language impairment (sli): a randomized controlled trial

Conditions: Language Impairment in School-years

Summary: specific-language-impairment (sli) is defined as a significant disorder in language development, which affects one's daily functioning, but not attributable to sensory, intellectual or neuropsychological deficit. children with sli make up one of the largest subgroups of students with special educational needs (sen) in hong kong. without appropriate intervention, sli may persist into adolescence and lead to long-term literacy difficulties and social rejection, which were found to be associated with societal problems like unemployment and crime commitment. among the language domains, syntax/grammar has been viewed as a core deficit in these children. speech-language-pathologists (slps) often provide intervention on this aspect for them. however, very few intervention efficacy studies could be identified. without pertinent research evidence, clinical-decision-making in treatment approach selection may be dubious. this study aims to evaluate the efficacy of two procedures for syntax intervention, namely the sentence-combining (sc) and narrative-based (nar) procedures using a randomized-controlled-trial (rct) design. these two procedures have been indicated to be effective in previous case reports and expert opinions. by using the rigorous study design of rct, this study provides stronger evidence to support clinicians in determining the most effective treatment procedure. to achieve sufficient statistical power to detect the treatment difference, 52 children with sli will be recruited and randomly assigned to one of the treatment groups. the primary outcome will be measured by a standardized language assessment. intention-to-treat analysis will be employed. pre- and post-treatment scores on the outcomes will be subject to analyses of covariance with the pre-treatment scores as the covariate.


Eligibility criteria:
inclusion criteria: * children in school years who were diagnosed as language with or with speech impairment by a qualified speech therapist; and * children failed in a standardized language assessment exclusion criteria: * children with sensory impairment and other diagnosed developmental disorders such as autism.

Keywords: language impairment language disorders syntax treatment narrative-based treatment
identifying barriers and strategies to support self-efficacy for medication adherence with text messaging

Conditions: Sickle Cell Disease

Summary: the investigators will explore barriers to improving self-efficacy, or the ability to feel in control of their disease, and medication adherence with text messaging through surveys and interviews with adolescents and adults with scd cared for at the vanderbilt meharry center of excellence (vmce) in sickle cell disease (scd). the investigators will identify preferences to improve and sustain adherence to daily medication through selection of investigator-proposed or patient-generated text messaging strategies. finally, the investigators will fill in the literature gaps by describing barriers to self-efficacy and medication adherence among adults with scd as well as adolescents with scd who are transitioning to adult care.


Eligibility criteria:
inclusion criteria: 1. receiving care at the vumc/matthew walker clinic 2. diagnosed with scd, asthma, or both 3. currently taking daily medications for scd, such as hydroxyurea, asthma, or both 4. having access to a mobile telephone and/or computer 5. age 12-70 years exclusion criteria: 1. unable to perform interviews or surveys
a registry study of runzaozhiyang capsule used in clinical real world

Conditions: Eczema

Summary: the purpose of this study is get to know what and how runzaozhiyang capsule in hospital results in drug-induced liver injury or adverse drug reactions from a cohort event monitoring as registration research.

in order to improving monitoring drug-induced liver injury or adverse drug reactions of chinese medicine containing radix polygoni multiflori in clinical real world, registry study is suitable method in this area. otherwise, nested case control study is used to find out the mechanism of drug-induced liver injury. calculate the incidence of drug-induced liver injury or adverse drug reactions is one of the main aims for this study. safety surveillance on chinese medicine containing radix polygoni multiflori is an important problem that needs to be sorted out through large sample observational study. according to the relevant regulations of the cfda, 3000 cases need to be registered at least. the aim population is who using runzaozhiyang capsule 's with abnormal liver function before medication from june 2017 to june 2019.

Eligibility criteria:
inclusion criteria: patients using runzaozhiyang capsule 's with abnormal liver function before medication from june 2017 to june 2019. exclusion criteria: none
feasibility and safety of a virtual-reality based job interview training tool in teenagers with high-functioning autism

Conditions: Autism Spectrum Disorder

Summary: the current project involves the application of a vr job training software. we propose to use an interactive vr job interview practice system, virtual reality job interview training (vr-jit), in youths with asd at the highschool level. this system was developed to bolster job interview practice skills and to help reduce anxiety in adults with asd. however, it has never before been used in individuals under the age of 18. our hope is that if this program is utilized in individuals while they are still in highschool, we can target those persons before the window for which risk of unemployment appears to be highest for asd youths, immediately after high school graduation.


Eligibility criteria:
inclusion criteria: * be between the ages of 13 and 18 * have a diagnosis of asd or a typically developing child * be able to speak and read english fluently exclusion criteria: * i had a stroke, tbi, or neurologic injury or disease in the past * i have a history of significant psychiatric illness (like bipolar, schizophrenia, or psychosis) * i have uncontrolled seizures or other unstable medical complications
smoflipid in patients who are intralipid intolerant

Conditions: Home Parenteral Nutrition; Short Bowel Syndrome

Summary: soybean oil based iv fat emulsion (ivfe) has been one of the sole sources of ivfe in the us. soybean oil based ivfe has higher ratio of omega-6 to omega-3 fatty acids and can be associated with a number of complications including inflammation, abnormal liver function tests (reflecting steatosis, cholestasis, etc.), and metabolic abnormalities. recently the fda has approved smoflipid which contains a mixture of soybean oil, medium chain triglycerides, olive oil, and fish oil. it provides a more positive ratio of omega-3 to omega-6 fatty acids and has been shown in short term trials to be beneficial in cases of intolerance to soybean oil ivfe. this study is designed to investigate the impact of smoflipid in prolonged use.


Eligibility criteria:
inclusion criteria: * age greater than 18 years * current mayo clinic hpn patient, able to provide informed consent, anticipated duration of hpn greater than 3 months * infusion company is able to provide smoflipid * no history of alcohol addiction * noted to be intolerant to so based ivfe as defined below. exclusion criteria: * pregnant women * failure to provide consent * patients who are deemed to be on hpn for less than three months * patients who have previous proven addiction and dependence to alcohol/ heavy alcohol consumption reported (during history or reported in the emr), known hypersensitivity to fish, egg, or soy, patients who will not be managed by the mayo clinic hpn team and patients who have active infection (as determined by the clinician) at the time of enrollment.
image-guided minimally invasive robotic surgery using preoperative ct scan for gastric cancer patients

Conditions: Gastric Cancer

Summary: the purpose of this study is to assess the feasibility of image-guided surgery in patients with early stage gastric cancer using robotic surgery with tile-pro program. for the assessment of the feasibility, conversion to open or laparoscopic surgery due to disturbance of will indicate the failure.

to assess the feasibility of image-guided surgery in patients with early stage gastric cancer using robotic surgery with tile-pro program. for the assessment of the feasibility, conversion to open or laparoscopic surgery due to disturbance of will indicate the failure. diagnosis of early stage gastric cancer -\> ct scanning \& eus for staging -\> (registration) -\> robotic surgery with image reconstruction -\> conversion rate, tumor location \& vascular anatomy correlation.

Eligibility criteria:
inclusion criteria: * patients who are older than 20 years * histologically confirmed gastric adenocarcinoma * patients who want robotic gastric cancer surgery * preoperative clinical stage stage i (t1n0, t1n1, t2n0) diagnosed with egd, eus \& ct scan * no history of drug allergy * creatinine \< 1.5 x upper normal limit * informed consent exclusion criteria: * previous history of upper abdominal surgery * patient refused the study
pecblock for the treatment of pain after breast surgery

Conditions: Cancer; Pain

Summary: pain after breast cancer surgery could be severe and about 1/3 of patients will develop chronic pain. the pecblock is the injection of local anesthetics between the two pectoral muscles to block pectoral nerves and intercostal nerves innervating the breast. the aim of this study is to evaluate the efficacy of the pecblock performed under echoguidance in minor and major breast surgery. the prevention of chronic pain following surgery will also be evaluated.


Eligibility criteria:
inclusion criteria: * women aged 18-85 yrs old * patients asa status i-iv exclusion criteria: * refusal of the pecblock * allergy to a drug used in the protocol (local anesthetic) * patients with chronic pain before the surgery

Keywords: postoperative pain chronic pain prevention regional anesthesia mastectomy
starling/crrt observational study

Conditions: Hemodynamic Monitoring

Summary: hemodynamic optimization of critically ill patients is a goal for clinicians in order to afford the patient the best possible outcomes. being able to precisely and rapidly determine patient fluid responsiveness provides the bedside physician and nursing staff the information needed to make critical decisions in regard to the patient's fluid status and management of additional fluids and medications. as fluid management and cardiac output determination are linked to better decision-making and improved outcomes in icu, the use of a dynamic assessment of fluid responsiveness becomes a key tool for patient management. this study is designed to collect treatment and outcome data on patients that have undergone hemodynamic monitoring during crrt therapy.


Eligibility criteria:
inclusion criteria: 1. ≥18 to 95 years of age. 2. patient has undergone hemodynamic monitoring with the starling monitor during a crrt treatment. 3. hemodynamic monitoring was completed no earlier than 2018 exclusion criteria: 1. patients did not have an arterial line in place during crrt treatment 2. patients on extracorporeal membrane oxygenation (ecmo) or left ventricular assist device (lvad) 3. patients with end-stage kidney disease on chronic dialysis 4. hemodynamic monitoring with starling did not occur during crrt treatment 5. data from starling, crrt machine, or arterial line cannot be retrieved

Keywords: cardiac index (ci) stroke volume (sv) stroke volume index (svi) stroke volume variation (svv) heart rate (hr) ventricular ejection time (vet) total peripheral resistance (tpr) total peripheral resistance index (tpri) cardiac power (cp) cardiac power index (cpi) blood oxygenation (spo2) oxygen delivery index (do2i) electrical impedance of the chest cavity (z0) thoracic fluid content (tfc) thoracic fluid content change from preset time period (tfcd) thoracic fluid content from baseline (tfcd0) changes in sv, co and other hemodynamic parameters which are derived by bioreactance® as a result of posture
mediges study: metformine use in gestational diabetes

Conditions: Diabetes, Gestational; Perinatal Disorder; Puerperal Disorder

Summary: women with gestational diabete (gd) who do not meet glycemic control objectives with diet will be assigned to two treatment groups randomly. one: metformin at a dose of 850-2550mg every 24h; two: insulin detemir associated or not with rapid insulin analogue (aspart) according to your glycemic controls. the metformin group may additionally receive insulin in a second time in case the glycemic control is not appropriate with monotherapy.

women with gestational diabete (gd) who do not meet glycemic control objectives with diet will be assigned to two treatment groups randomly. one: metformin at a dose of 850-2550mg every 24h; two: insulin detemir associated or not with rapid insulin analogue (aspart) according to your glycemic controls. the metformin group may additionally receive insulin in a second time in case the glycemic control is not appropriate with monotherapy. the objectives are: demonstrate that treatment with metformin in women with gd (not controlled with diet) can get no lower obstetric and perinatal outcomes than those with standard treatment with insulin. demonstrate that glycemic control with metformin in properly selected women, can be equivalent to that obtained with insulin.

Eligibility criteria:
inclusion criteria: 1. 18-45 years old. 2. diagnosis of gd, with fasting glucose \<120 mg / dl. 3. not controlled by diet: fasting capillary blood glucose\> 95 mg / dl in at least 2-3 times or 1 hour postprandial \>140 mg / dl on, at least 2-3 times a week. 4. 2nd or 3rd trimesters of pregnancy. 5. able to give informed consent. exclusion criteria: 1. psychopathological situations that do not guarantee proper adhesion to follow up 2. 1st trimester of pregnancy 3. gastrointestinal diseases that may cause poorer tolerance or increased symptoms with metformin. 4. patients who can not attend the scheduled consultation. 5. language barrier limiting for understanding treatment settings 6. twin pregnancy.
severe intraoperative hyperglycemia during craniotomy and postoperative infections

Conditions: Patients Undergoing Craniotomy for Brain Surgery

Summary: aim of this prospective observational study -in patients undergoing craniotomy for supra or infratentorial surgery as elective or emergency procedure- is to test the hypothesis that severe intraoperative hyperglycemia (bgc ≥180mg/dl) is associated with an increased incidence of infections within the first postoperative week (pneumonia, blood stream, urinary, surgical site/wound and cerebral infections)(nct01923571).


Eligibility criteria:
inclusion criteria: * age \>18 * undergoing elective or emergency craniototmy exclusion criteria: * age \<18
effect of breathing exercises applied to hemodialysis patients on anxiety, fatigue and quality of life

Conditions: Exercise; Hemodialysis

Summary: breathing exercises are one of the non-pharmacological methods frequently used in health care in recent years. the aim of this study is to evaluate the effect of breathing exercises on fatigue, anxiety symptoms and quality of life in hemodialysis patients.

introduction: breathing exercises are one of the non-pharmacological methods frequently used in health care in recent years. objective: the aim of this study is to evaluate the effect of breathing exercises on fatigue, anxiety symptoms and quality of life in hemodialysis patients. method: this study will be conducted using a randomized controlled experimental research design at the pre-test-post-test level. the research sample will consist of 58 hemodialysis patients who meet the inclusion criteria of the sample and who apply to the hemodialysis unit of a training and research hospital. the research data will be collected using the personal information form, beck anxiety inventory, piper fatigue scale and sf-12 quality of life scales. the pre-test data of the research will be filled in the first interview with the patients and the post-test data will be applied at the end of the 6th week. conclusion: maintaining physical and psychological comfort and improving the quality of life of patients receiving hemodialysis treatment are among the primary responsibilities of the nurse. in this regard, it is predicted that breathing exercises will be beneficial in controlling physical and psychological symptoms.

Eligibility criteria:
inclusion criteria: * being over the age of 18 * being willing to participate in the study * speaking and understanding turkish * having started hemodialysis treatment at least 6 months ago exclusion criteria: * being on hemodialysis treatment with a diagnosis of stage 4 renal failure * being on hemodialysis treatment due to acute renal failure * having a malignancy related to the respiratory system (bronchus or lung) * having chest pain . -having previously done box breathing and diaphragmatic breathing exercises/receiving training * having cognitive dysfunction * not giving consent to participate in the study

Keywords: anxiety fatigue quality of life
screening for research subjects with anterior segment diseases

Conditions: Eye Diseases

Summary: this study will identify patients with anterior segment disease who may be eligible to participate in current or future nei studies on this disease. anterior segment disease includes all disorders that affect the eye surface, anterior chamber, iris and ciliary body and lens of the eye. the eye surface is composed of the cornea, conjunctiva, eyelids, lacrimal and meibomian glands, and the interconnecting nerves. patients of any age with anterior segment disease may be eligible for this screening study. participants will be evaluated with some or all of the following tests and procedures, depending on the nature of their eye problem: * medical history and brief physical examination. * eye examination, including measurement of visual acuity (eye chart) and eye pressure, examination of the pupils, eye movements, structures in the front of the eye (cornea, conjunctive, etc.), the lens, and the structures in the back of the eye (retinal, optic nerve, etc.). * photographs of the eye to help assess the status of the cornea and conjunctive and to evaluate any changes that may occur in the future. * assessment of tear and surface status. the amount of tears the eyes can produce is measured by placing a small piece of sterile paper in the corner of the eye every 5 minutes. special orange and green dyes are placed in the eyes to determine the health status of the surface of the eye. * corneal or conjunctival biopsy. a small tissue sample from the surface of the eye may be removed for laboratory examination to help diagnose a condition that is unclear. for this procedure, the eye is numbed with anesthetic eye drops. the required tissue is collected, an antibiotic ointment is placed in the eye to prevent infection, and a patch may be placed over the eye for 12 to 24 hours. * blood draw for tests to study the cause of the patient's eye disease. * other diagnostic tests as needed. * dna testing to look for a genetic pattern associated with the patient's eye disease. patients who are found eligible for an nei study will be offered participation in that study. patients who are not eligible for current studies will be advised about treatment options.

this is a screening protocol that will allow the nei clinicians to examine patients with ocular diseases in order to identify those who may be eligible to participate in other nei studies on anterior segment disease.

Eligibility criteria:
* eligibility criteria: to participate in this screening study, a patient must have a history of anterior segment disease. patients of all ages are eligible.

Keywords: cornea conjunctiva keratitis ocular surface inflammation evaluation screening ocular surface disease eye ocular disease anterior segment disease
microbiome determinants of neurological and gastrointestinal symptoms of autism spectrum disorder (asd)

Conditions: Autism Spectrum Disorder

Summary: this observational study aims to identify human microbiome determinants of the symptoms associate with asd as well as identify the human microbiome determinants of the success of fmt (fecal matter transplant) therapy and to develop a statistical model that can improve fmt donor-recipient matching. participants are recruited through novelbiome only, this study will not utilize other clinical sites.

this longitudinal, observational study aims to identify human microbiome determinants of the symptoms associate with asd as well as identify the human microbiome determinants of the success of fmt therapy and to develop a statistical model that can improve fmt donor-recipient matching. participant phenotype data and samples are collected at several time points relative to their receiving fmt therapy. participants will collect stool, urine, environmental swabs, saliva, and blood at home via vls's (viome life sciences) at-home kits mailed to them by vls. the at-home samples are collected by participants (and when appropriate lar/guardian). the samples are then returned to vls via postage-paid mailers (provided). these samples are analyzed by the vls laboratory.

Eligibility criteria:
inclusion criteria: * diagnosis of asd, from medical records, self-diagnosed and/or lar reported (lar = legally authorized representative) * plans to undergo fmt treatment at a novel biome clinic * consented to participate in the study exclusion criteria: * active cancer therapy * antibiotic use within 30 days prior to starting the fmt therapy. fmt therapy itself starts with antibiotic treatment.

Keywords: fecal matter transplant fmt autism
mathematically arterialised testing of hypercapnic subjects study

Conditions: Hypercapnic Respiratory Failure

Summary: prospective observational cohort study of patients admitted to hospital with suspected hypercapnic respiratory failure and requiring treatment with non-invasive ventilation (niv) as part of standard, routine management. contemporaneous blood gas samples will be obtained via arterial, capillary, and venous methods. the venous samples will undergo mathematical arterialisation via the v-tac system. in line with standard medical care, arterial samples will be obtained before starting niv and at two set points afterwards (day 1 post-niv, and pre-discharge). pre-existing clinical thresholds will be used to assess the reliability of v-tac against abg, the existing gold standard and will conduct a retrospective model of decision-making once the blood sampling component of the study is concluded.


Eligibility criteria:
inclusion criteria: * aged 18 years or above. * admitted for consideration of home non invasive ventilation. * due to undergo arterial blood gas sampling as part of routine clinical care exclusion criteria: * inability to provide informed consent. * clinical necessity to perform blood gas sampling prior to allowing sufficient time for informed consent. * inability to obtain reliable spo2 readings