Kornimate/medical-research-clean huggingface dataset:
effect of targeted health education program on nurses' awareness about postpartum depression

Conditions: Postpartum Depression

Summary: to assess nurses' knowledge of ppd at ain shams university maternity hospital and measure their knowledge level after an educational program on postpartum depression.

postpartum depression (ppd) is a serious mental illness that involves the brain and affects behavior and physical health of women after childbirth . multiple factors may influence ppd, such as lack of support, interpersonal events, withdrawal of hormones after delivery, psychosocial stressors, psychological stressors, personality, environment, and ineffective adaptation. symptoms of ppd may include feeling restless or moody, feeling sad, crying a lot, having thoughts about hurting the baby or yourself, not feeling connected to the baby, having no energy or motivation, eating, or sleeping too little or too much, feeling worthless and guilty, losing interest or pleasure in activities, and withdrawing from friends and family . ppd is one of the most important health problems due to its prevalence; 10-15% . and serious negative mother-baby outcomes. ppd affects the health of mothers and their newborns and is associated with long-term psychological and socioeconomic implications . as the knowledge affects attitudes and practices of people, nurses' knowledge can affect profoundly women after birth specially regarding ppd . in an american web-based study , nurses' self-efficacy about ppd was associated to their knowledge . in another american electronic survey of 372 nurses, 95% reported an association between post-partum education and mortality and 72% reported that it is their responsibility to provide education to mothers . in a ghanaian study, nurses had good knowledge about ppd but poor knowledge about screening and management . in a kazakh study, 90% of nurses didn't attend training courses on ppd ). furthermore, in a malaysian study, 44.4 % of participants were below than median total knowledge score and only 25.9% practiced screening. in a saudi study, the confidence of nurses and midwives to educate women about ppd was associated with their knowledge. in a turkish study, 84.4 % of nurses had little knowledge and 75.5% reported that psychological service for evaluating mothers wasn't offered. ppd can have devastating effects on women, their infants, and families associated with lower levels of bonding and reduced breastfeeding initiation and duration. consequently, women experiencing ppd may cause harm to their baby, themselves, or others. as, nurses in maternity hospitals are poised to play a pivotal role in the early identification and prompt treatment of ppd, assessing their knowledge is very important. to date, according to our knowledge, there is no previous study in egypt assessing the nurses' knowledge about ppd, therefore the present study will be conducted to compare their knowledge regarding ppd before and after the health education program.

Eligibility criteria:
inclusion criteria: * nurses at ain shams university maternity hospital exclusion criteria: none -
euro-stim registry

Conditions: Obstructive Sleep Apnea; Obstructive Sleep Apnea (OSA)

Summary: the registry is to measure longitudinal outcomes and adherence of the inspire system. the goal of the registry is to capture the life cycle of the patient's use of the inspire system through routine clinical care visits. there are no required interventions or testing.


Eligibility criteria:
inclusion criteria: any patient implanted with or receiving an inspire implant, who meets the following criteria, is eligible to participate in the registry: 1. capable of giving informed consent, as required per institution 2. willing to return for routine clinic visits as required for inspire therapy management exclusion criteria: any patient who meets any of the following criteria will not be eligible to participate in the registry: 1. has a life expectancy of less than one year 2. any reason the clinician deems patient is unfit for participation in the study

Keywords: sleep apnea osa inspire obstructive sleep apnea
examining the effectiveness of combined rehabilitation and botulinum toxin injection on functional improvement of the upper limb after stroke

Conditions: Stroke

Summary: the purpose of this study is to examine the effects of a combination of "botulinum toxin (bt) and upper limb (ul) rehabilitation" compared to "bt only" on ul motor function in adults with spasticity after stroke using a pre-post design. the research question is whether combination of bt and ul rehabilitation compared to bt only is more effective in improving the ul function, range of motion and pain.


Eligibility criteria:
inclusion criteria: * over 18 years of age * at least 4 months post stroke * present with ul spasticity (mas \>1 in elbow and/or spasticity of the hand, wrist or shoulder) * present with at lease a stage 3 of cmsa * able to comply with the requirements of the protocol and ul therapy programme. exclusion criteria: * significant cognitive and speech impairments * other upper limb impairments such as frozen shoulder * another diagnosis which could contribute to upper limb spasticity .

Keywords: stroke upper limb rehabilitation function
diffuse fibrotic lung disease

Conditions: Lung Diseases; Pulmonary Fibrosis; Sarcoidosis

Summary: to determine the effects of cyclophosphamide compared with prednisone, dapsone, or high-dose intermittent 'pulse' therapy with methylprednisolone in patients with idiopathic pulmonary fibrosis. also, to evaluate the use of intermittent, short-term, high-dose intravenous corticosteroids in patients with sarcoidosis. there were actually four separate clinical trials.

background: the fibrotic lung diseases represent 15 to 20 percent of the non-infectious disorders of the lung. idiopathic pulmonary fibrosis, one of the 10 general groups of fibrotic lung disorders, is a chronic and devastating illness resulting in death within an average of 4 to 5 years from the onset of symptoms. although 5 to 10 percent of these patients respond to corticosteroids, there is no known treatment for the remainder. sarcoidosis, a generalized disorder characterized by epithelioid cell granuloma formation in affected organs, especially the lung and lymphoid tissue, has a clinical course that varies considerably from patient to patient and, in some cases, resolves spontaneously. in other cases, intermittent pneumonitis develops, which may result in a permanent loss of lung function. large intermittent doses of corticosteroids might be superior to conventional high-dose corticosteroids in patients with pulmonary sarcoidosis which has not resolved spontaneously. design narrative: in the randomized, non-blind cyclophosphamide versus prednisone trial, 25 to 50 patients with idiopathic pulmonary fibrosis were assigned to treatment with prednisone or cyclophosphamide. at the end of 52 weeks of drug therapy, both groups were treated using conventional medical therapies. in the non-randomized dapsone trial, 10 fibrotic patients were treated with dapsone and prednisone for one year. in the double-blind, randomized methylprednisolone trial, 25 to 50 patients were given low-dose methylprednisolone, and, in addition, all patients were randomized to either high-dose methylprednisolone treatment or to placebo at weekly intervals for one year. in the randomized, double-blind, high-dose corticosteroid trial, 25 to 50 patients with pulmonary sarcoidosis were given a short intense course of high-dose methylprednisolone or a placebo for 6 weeks. the study completion date listed in this record was inferred from the last publication listed in the citations section of this study record.

Eligibility criteria:
no eligibility criteria
healthy life centers - municipal health care service for lifestyle changes - a multicenter intervention study

Conditions: Musculoskeletal Disease; Obesity; Psychological Disorder

Summary: a healthy life center (hlc, 'frisklivssentrale') is a public community-based health service providing lifestyle support programs for physical activity, smoking cessation and diet, to inhabitants with increased risk for development of non-communicable diseases. hlcs intention is to reach physically inactive people who need guidance to get more physically active, and offer them a lifestyle program for three months or more. the main aim of this study is to study whether the hlcs, organized according to the norwegian directorate of health's guidelines for municipal healthy life centers, affects the participants short term (3 months) and long term (15 months) physical activity level. also changes in diet, tobacco use, health related quality of life, physical fitness, anthropometry, self-efficacy, motivation, drug use, use of health services and work participation will be assessed. secondary aim is to study whether there are any moderators, such as hlcs capacity, expertise, and collaboration with other services, that have significance for participants' change. also it will be studied whether the hlcs result in larger changes in some subgroups (e.g. socioeconomic) of participants than in others.


Eligibility criteria:
inclusion criteria: * about to start structural support for lifestyle change (regarding physical activity, diet and/or tobacco cessation * referred to a healthy life center (hlc) from either primary physician, from other health care services or social services, or participants seeking contact themselves without a specific referral. exclusion criteria: * having participated in an hlc the previous 6 months

Keywords: physical fitness health status exercise tobacco use cessation quality of life healthy diet health promotion patient education as topic counseling
noninvasive intracranial pressure from transcranial doppler ultrasound development of a comprehensive database of multimodality monitoring signals for brain-injured patients

Conditions: Traumatic Brain Injury; Subarachnoid Hemorrhage; Intracerebral Hemorrhage; Liver Failure; Ischemic Stroke

Summary: this is an observational study in neurocritical care units at university of california san francisco medical center (ucsfmc), zuckerberg san francisco general hospital (zsfgh), uc davis, and emory university. in this study, the investigators will primarily use the monitor mode of the transcranial doppler (tcd, non-invasive fda approved device) to record cerebral blood flow velocity (cbfv) signals from the middle cerebral artery and internal carotid artery. tcd data and intracranial pressure (icp) data will be collected in the following four scenarios. each recording is up to 60 minutes in length. multimodality high-resolution physiological signals will be collected from brain injured patients: traumatic brain injury, subarachnoid and intracerebral hemorrhage, liver failure, and ischemic stroke. this is not a hypothesis-driven study but rather a signal database development project with a goal to collect multimodality brain monitoring data to support development and validation of algorithms that will be useful for future brain monitoring devices. in particular, the collected data will be used to support: development and validation of noninvasive intracranial pressure (nicp) algorithms. development and validation of continuous monitoring of neurovascular coupling state for brain injury patients development and validation of noninvasive approaches of detecting elevated icp state. development and validation of approaches to determine most likely causes of icp elevation. development and validation of approaches to detect acute cerebral hemodynamic response to various neurovascular procedures.


Eligibility criteria:
inclusion criteria: 1. male or female subjects 18 years of age and older 2. subjects who have an icp monitoring device exclusion criteria: 1. unstable medical illness such as recordings might interfere with medical care. 2. subjects that don't have a viable temporal window to insonate the mca. 3. subjects that have skull fractures that the attending or study investigators believe participation would add clinical risk to the subject.
drug-eluting balloon for treatment of non-atherosclerotic renal artery stenosis

Conditions: Hypertension, Renovascular

Summary: efficacy of drug eluting balloon(deb) for non-atherosclerotic renal artery stenosis will be tested in this study. the intervention group will be treated with paclitaxel eluting balloon. the control group will be treated with plain old balloon(pob). the primary endpoint is efficacy of blood pressure control.

renal artery stenosis is common cause for hypertension in young people. it could be treated with open surgery or endovascular intervention. open surgery has relatively high complication rate. endovascular intervention is micro-invasive but with high restenosis rate. drug eluting balloon(deb) has been demonstrated to be effective for preventing restenosis in peripheral arteries. this study aims to test the efficacy of drug eluting balloon for non-atherosclerotic renal artery stenosis. the intervention group will be treated with paclitaxel eluting balloon. the control group will be treated with plain old balloon. the primary endpoint is efficacy of blood pressure control.

Eligibility criteria:
inclusion criteria: 1. age between 18y and 45y. 2. with ≥ 60% stenosis in at least one renal artery. 3. with hypertension (systolic blood pressure ≥140 mmhg or diastolic blood pressure ≥ 90 mmhg). 4. patients with no severe renal insufficiency (egfr\>30 ml/min, length of the kidney ≥ 7cm). 5. good compliance. 6. with informed consent. exclusion criteria: 1. with apparent atherosclerotic risk factors. 2. with renal intervention or surgery history. 3. with congenital anatomical anomaly. 4. with severe renal insufficiency (length of the target kidney \< 7cm, total egfr\<30ml/min, divided egfr of the target kidney\<8 ml/min) 5. with contraindication for antiplatelet therapy. 6. with severe cardiopulmonary insufficiency. 7. allergic to contrast medium 8. being pregnant or preparing for pregnancy 9. with active cancer. 10. life expectancy \< 12 month 11. without informed consent.

Keywords: renal artery obstruction takayasu arteritis fibromuscular dysplasia
prevalance of cesarean section niche in patients with abnormal uterine bleeding

Conditions: Cesarean Section Niche and Abnormal Uterine Bleeding

Summary: prevalance of cesarean section niche in patients with abnormal uterine bleeding


Eligibility criteria:
inclusion criteria: age between 20-40 years old. non pregnant women. previous cesarean section (one or more). presence of abnormal uterine bleeding exclusion criteria: virgins pregnant women. patients with vaginal delivery. patients with uterine bleeding with known cause.
study of trph-222 in patients with relapsed and/or refractory b-cell lymphoma

Conditions: Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Mantle-Cell; Lymphoma, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular

Summary: this is a phase 1, multi-center, open-label study of trph-222 monotherapy in subjects with relapsed and/or refractory b-cell nhl. the study will be conducted in two stages: dose-escalation, dose-expansion.

in dose escalation, patients with dlbcl, fl (including transformed fl), mzl, and mcl were to be enrolled per dose cohort. in dose expansion, additional response-evaluable patients were to be enrolled in nhl subtype-specific cohorts including dlbcl and fl to confirm the rp2d identified in escalation. each stage consisted of screening, baseline, treatment, and follow-up periods. during the treatment period, patients were to be treated indefinitely in 21 day cycles. the eot assessments were to occur 28 and 60 days after the last study treatment.

Eligibility criteria:
inclusion criteria * age ≥ 18 years at the time of signing the informed consent * histologically confirmed (2016 who lymphoma classification) b-cell nhl that is dlbcl, fl (including transformed fl), mzl, or mcl * relapsed and/or refractory nhl requiring systemic therapy and have failed, are intolerant to, or are considered ineligible for standard of care anticancer treatments that are known to be potentially curative. subjects must not be current candidates for hsct. participants who refuse standard treatments may also be considered provided that documentation is provided that the subject has been made aware of all therapeutic options * eastern cooperative oncology group (ecog) status 0-2 exclusion criteria * presence of a leukemic phase of the lymphoma * "double hit" or "triple hit" germinal center b cell lymphoma * previous solid organ allograft (except for corneal transplant) * peripheral neuropathy \> nci-ctcae grade 1 * significant organ dysfunction that would preclude study participation * significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias * any other serious active disease or co-morbid medical condition, according to the investigator's decision or medical monitor, that will substantially increase the risk associated with the subject's participation in the study

Keywords: antibody-drug conjugate adc cd22 smartag™ technology trph-222
treatment of amd with rheohemapheresis /rhf/

Conditions: Age Related Macular Degeneration

Summary: in this research rheohemapheresis will be used for the treatment of patients with high-risk dry form of age-related macular degeneration. correction of rheologic parameters and activation of retinal functional reserves after the therapy will positively influence functional condition of retina. the newest special electrophysiologic methods will be used to determine retinal changes in time. the investigators will also evaluate some important immunologic factors and complement changes as well as define indication criteria more precisely.

with optimized therapeutic protocol we would prevent progression of the dry form of amd into its devastating wet form and stabilize the situation. we suppose that retinal morphologic and functional conditions would improve in a high percentage of patients. also possible technical and economic savings would not be less important with our own therapeutic protocol, especially, when blindness could be prevented.

Eligibility criteria:
inclusion criteria: patients with amd in the stage of soft drusen, grade 1-3 according to european eye study (euryeye) (see reference no 1), body weight over 50 kilo and with other feasible indications for aphereses therapy (peripheral veins allowing vascular access to establish the extracorporal circuit). - exclusion criteria: * study eye with exudative amd * study eye with concomitant retinal or choroidal disorder other than amd * study eye with significant central lens opacities and/or conditions that limit the view of the fundus * uncontrolled diabetes, uncontrolled arterial hypertension * insufficient antecubital venous access * haemato-oncological malignancies * patients who are unwilling to adhere to visit examination schedules . poor general condition (serious diseases - infections,cardiovascular or cerebral insufficience, severe ihd)

Keywords: age-related macular degeneration amd rheohemapheresis plasma filtration electroretinography erg multifocal erg double plasma filtration
fetal cardiac function

Conditions: Fetal Growth Retardation

Summary: the aim of our study is to evaluate the effect of pe and fgr on fetal cardiac function. pregnancies with preeclampsia and fgr, and preeclampsia with normal fetal growth are evaluated by echocardiography and compared with uncomplicated pregnancies.

preeclampsia (pe) represent a major concern in public health, affecting 2-8% of all pregnancies and considered one of the leading causes of perinatal morbidity and mortality. fetal growth restriction (fgr) ia also a common health problem affecting about 5-10% of all pregnancies and commonly associates with preeclampsia . it is estimated that 20% of cases of pe present with fgr and about 50% of early-onset fgr cases will eventually coexist with pe . both syndromes share some pathophysiologic features, with a variable involvement of placental insufficiency and cause fetal cardiovascular remodeling and adaptations . fetal adaptations as metabolic and cardiovascular programming occur in response to adverse intrauterine conditions as pe and fgr . offspring from preeclamptic pregnancies showed cardiac structural and functional changes and greater blood pressure in childhood and adolescence . most of the studies on fgr included pregnancies complicated by pe and vice versa, which fails to adequately assess the independent effect of each condition on the fetal cardiac functions.

Eligibility criteria:
inclusion criteria: * pregnant women more than or equals 28 weeks * preeclampsia defined as systolic blood pressure 140 mm hg and/or diastolic blood pressure 90 mm hg * fetus with normal growth or with growth restriction exclusion criteria: * congenital malformations * intrauterine infection * multiple pregnancies * fetuses of mothers treated with a tocolytic agent * fetuses with abnormal heart rates (tachycardia or bradycardia)
the effectiveness of an exercise program on scapulohumeral rhythm, range of motion, and stability in young female handball players

Conditions: Scapular Dyskinesis; Handball Players; Female Athlete

Summary: the primary objective of this study is to investigate the effectiveness of a shoulder girdle exercise program in improving stability, range of motion, and motor control in female handball players.

the aim of this study is to investigate the effects of a structured shoulder girdle exercise programme on stability, range of motion (rom) and motor control in female handball players. the study will be conducted over a period of 8 weeks and will involve 60 participants aged 17-30 years recruited from professional handball clubs. participants will be randomly assigned to either the experimental group, which will follow a modified version of the watson programme, or the control group, which will continue with their standard training programme. aims: - to compare the effects of the upper scapular rotation-oriented exercise intervention with a standardised upper extremity exercise programme. - scapulohumeral rhythm assessment: to assess scapulohumeral rhythm at different angles of shoulder flexion (30°, 60°, 90° and 120°) in young female handball players, with a focus on identifying potential asymmetries between the dominant and non-dominant limbs. - analysis of scapular kinematics: to measure scapular upward rotation, anterior/posterior tilt and medial/lateral translation at different degrees of shoulder flexion to identify movement patterns associated with scapular dyskinesis. - functional stability analysis: to assess upper extremity functional stability using the y-balance upper quarter test (ybt-uq) and the closed kinetic chain upper extremity stability test pre- and post-exercise to identify potential correlations between stability improvements and changes in scapular rhythm and muscle activation. - isometric strength measurement: to evaluate isometric strength in shoulder abduction, internal rotation and external rotation using the lafayette hhd handheld dynamometer to assess the impact of the intervention on shoulder muscle performance.

Eligibility criteria:
inclusion criteria: * healthy individuals with no reported health problems * no history of shoulder or elbow surgery within the past 2 years * received information about the study * written consent from the participant to participate in the study, including video recording and photography exclusion criteria: * injury or trauma to the upper extremity within the past 3 months * illness that prevents participation in the study or tests * heavy physical activity of the shoulder girdle within 2 hours prior to the study * orthopedic surgery or physiotherapy treatment of the shoulder girdle

Keywords: handball sports performance assessment muscle strength assessment scapular scapular dyskinesis