Kornimate/medical-research-clean huggingface dataset:
evaluation and development of playing skills for parents with children with special needs

Conditions: Play and Playthings

Summary: children with special needs; experiences physical, behavioral, social, cognitive and emotional limitations. these limitations affect the child's play skills. they need to be supported and encouraged by their parents to enable them to participate in the game. parental playing skills creativity, self-efficacy and active participation are important factors in this regard. in current studies, parents with special needs children; it is supported that there is a relationship between play, acting and parental self-efficacy. in this study, it was aimed to improve the skills of parents with special needs children to play games with their children multidimensionally and to develop these skills with individual-specific techniques. detailed assessments will be carried out in order to determine the functional, cognitive and psychosocial skills of the parents. after the evaluation phase is completed, the scores of each parent will be analyzed and interpreted according to occupational therapy models. playing training will be given individually according to parameters such as strong and weak features, strong sensory system, personality traits, predisposition and defensive approaches.


Eligibility criteria:
inclusion criteria: * being a mother of a special needs child * the age of her child is 2-6 years * being able to speak turkish * volunteer to participate in the study exclusion criteria: * have training in play therapy * having a psychiatric or neurological disease that significantly affects cognitive status

Keywords: neurodevelopmental disorders, autism spectrum disorders, parents, mentoring, play and playthings
anatomical study of the arteries of the skin on amputation legs

Conditions: Arteritic Leg Ulcer

Summary: primary objective qualitatively describe the distribution of cutaneous arteries in patients with long-term occlusive arterial disease. secondary objective to compare the distribution of cutaneous arteries observed on the legs of arteritic patients with that observed on non-arteritic legs (from bodies given to science).

arterial patient coming to chru nancy, in the vascular and endoluminal surgery department, to undergo leg amputation. usually, after the amputation of the leg in the operating theatre, the surgical waste is destroyed. instead of being destroyed, the leg will be used for research.

Eligibility criteria:
inclusion criteria: * major patient * patient with late stage occlusive arteriopathy with lower limb amputation * patient who did not oppose the search * patient affiliated to a social security scheme exclusion criteria: * patients with infectious diseases not accessible in the anatomy laboratory * woman of childbearing age without effective contraception * persons referred to in articles l. 1121-5 to l. 1121-8 and l1122-2 of the public health code : * pregnant woman, parturient or nursing mother * person deprived of liberty by a judicial or administrative decision, * person under psychiatric care pursuant to articles l.3212-1 and l.3213-1 of the public health code * person admitted to a health or social institution for purposes other than research * minor person (not emancipated) * adult subject to a legal protection measure (guardianship, trusteeship, protection of justice) * major person who is not in a position to express consent and who is not subject to a legal protection measure
assessment of the effects of chondroitin sulphate in patients with knee osteoarthritis with functional magnetic resonance imaging (fmri)

Conditions: Knee Osteoarthritis

Summary: the main purposes of this study are: * to determine the effects of chondroitin sulphate on brain response to pain assessed through fmri in patients with knee osteoarthritis. * to investigate the relationship between treatment response detected by fmri and the results of the different parameters of clinical assessment.


Eligibility criteria:
inclusion criteria: * primary knee oa according to acr criteria * oa of radiological stages 2 to 3 according to kellgren-lawrence * estable knee pain during the last months before to start the clinical trial * patients with pain as the vas≥50mm at baseline exclusion criteria: * patients with skin conditions that could interfere in the clinical trial evaluation * pregnant or breastfeeding woman * patients with a history of alcoholism or other drug abuse * patients with an uncontrolled active psychiatric disorder * patients with other inflammatory or systemic conditions affecting other joints * patients who suffer more intense pain in the joint in another location * patients unable to differentiate between symptoms caused by the knee in front of the joint study opposite * oa of radiological stages 1 or 4 according to kellgren-lawrence * other bone and articular diseases such as chondrocalcinosis, paget's disease, rheumatoid arthritis, aseptic osteonecrosis, gout, septic arthritis, ochronosis, acromegaly, hemochromatosis, wilson's disease, osteochondromatosis * patients with contraindications to perform an mri such as: certain tattoos, pacemakers, intracranial clips incompatible with mri, in the heart valves, hearing aids and other types of implants are incompatible with mri * known allergy to chondroitin sulphate * washout period for oa treatments before beginning the study

Keywords: chondroitin sulphate knee osteoarthritis functional magnetic resonance imaging
a comparison of exparel local anesthetic in total knee arthroplasty (tka) patients

Conditions: Osteoarthritis, Knee; Arthroplasty, Replacement, Knee

Summary: this is a prospective, single-center, single-blinded, randomized, case-control study. the study is conducted by a single investigator at an orthopedic surgery institute, with a minimum 6 week post operative follow-up period of tka patients who receive exparel compared with the surgeon's standard method (detailed below) for pain management intraoperatively.

this is a prospective, single-center, single-blinded, randomized, case-control study. the study is conducted by a single investigator at an orthopedic surgery institute, with a minimum 6 week post operative follow-up period. subjects scheduled for a planned total knee arthroplasty procedure will be consented and those meeting study criteria will be randomized to receive intra-operative injections at the surgical site of liposomal bupivicaine plus a multi-drug cocktail, or a multi-drug cocktail alone. this study will recruit subjects on an ongoing basis with a minimum of 130 study participants and a maximum of 156. efficacy data on surgical pain control and safety data will be collected at frequent intervals during the hospitalization. each study participant will be followed for a minimum 6 week follow-up period.

Eligibility criteria:
inclusion criteria: 1. 18 to 88 years of age. 2. subject is scheduled to undergo primary unilateral total knee arthroplasty. 3. subject willing and able to sign the informed consent. 4. subject is fluent in verbal and written english. 5. subject agrees to take liposomal bupivacaine or standard of care equivalent. exclusion criteria: 1. previous partial or total knee arthroplasty of the study knee. previous non-implant surgery on the study knee and contralateral knee is permitted. 2. subject is pregnant or planning to become pregnant while enrolled in the study. 3. subject has a history of narcotic or alcohol abuse. 4. subjects with hepatic disease or renal impairment (alanine aminotransferase (alt) or aspartate aminotransferase (ast) \>2.5 x upper limit of normal or estimated glomerular filtration rate (egfr) \< 30 ml/min within 30 days of surgery). 5. for any reason, in the opinion of the investigator, the subject may not be a suitable candidate for study participation (i.e., history of noncompliance, drug dependency, etc.)

Keywords: tka knee replacement arthritis knee
renal resistive index in septic shock patients

Conditions: Septic Shock

Summary: septic shock is a condition of acute circulatory failure and is defined as a process that requires the use of vasopressors to ensure adequate tissue perfusion when hypotension develops. it is mainly characterized by abnormal peripheral vascular resistance; therefore, improving vascular function and organ damage is crucial in the management of septic shock. blood flow measurement with doppler-based renal resistive index (rri), which can be performed at the bedside, especially in renal abnormalities, is currently accepted as a tool to assess renal perfusion. with this simple, rapid and reproducible technique, the investigators determine rri by evaluating systolic and diastolic blood velocity from doppler flow waveforms in the intrarenal arcuate or interlobar arteries. our aim is to investigate the relationship between renal resistive index (rri) and global tissue hypoperfusion parameters and clinical outcomes in septic shock patients admitted to the intensive care unit and receiving invasive mechanical ventilator support.

it is planned for patients who are admitted due to septic shock and need invasive mechanical ventilator support, who have a central venous catheter inserted for central venous pressure measurement and advanced monitoring, and who have undergone invasive arterial monitoring for close hemodynamic monitoring. after initial hemodynamic stabilization is achieved, rri will be calculated by renal ultrasonography within 24 hours. simultaneously with renal ultrasonography, blood samples will be taken from arterial and central venous catheters, partial arterial oxygen pressure (pao2), partial arterial carbon dioxide pressure (paco2), partial central venous oxygen pressure (pcvo2) and partial central venous carbon dioxide pressure (pcvco2), arterial oxygen saturation (sao2), central venous oxygen saturation (scvo2), hemoglobin concentration and arterial lactate levels will be recorded. an attempt will be made to gain an idea about the course of the disease by comparing rri with these global tissue hypoperfusion parameters.

Eligibility criteria:
inclusion criteria: * followed up due to sepsis * in need of intensive care follow-up * in need of invasive mechanical ventilation * sofa score \>2 exclusion criteria: * hypothermic patients (\<35c) * with chronic renal failure * pregnant women * those with renal artery stenosis * structural kidney damage * patient with previous renal surgery * intra-abdominal postoperative surgery patients * patients with atrial fibrillation
role of acute phase proteins in diagnosis of immune thrombocytopenia

Conditions: Immune Thrombocytopenia

Summary: immune thrombocytopenia (itp) are antibody-mediated disorders in which platelets are destroyed mainly through activating immunoglobulin (igg) fc receptors on phagocytes in the spleen and liver, eventually resulting in thrombocytopenia acute phase proteins (app) are inflammation markers that exhibit significant changes in serum concentration during inflammation. these are also important mediators produced in the liver during acute and chronic inflammatory states. acute phase reactants can be classified as positive or negative, depending on their serum concentrations during inflammation. positive acute phase reactants are upregulated, and their concentrations increase during inflammation. negative acute phase reactants are downregulated, and their concentrations decrease during inflammation. positive acute phase proteins include procalcitonin, c-reactive protein, ferritin, fibrinogen, hepcidin, and serum amyloid a. negative acute phase reactants include albumin, prealbumin, transferrin, retinol-binding protein, and antithrombin crp is now well established as a major acute phase protein and is used in daily clinical practice as a sensitive biomarker for infection and inflammation, with its level increasing from \ 500 mg/l after acute infections. crp is produced by hepatocytes, in response to inflammatory cytokines such as interleukin (il)-6 and il-1, with serum concentrations rising to \>5 mg/l after 6 hours and peaking after ∼48 hours. in healthy young adult volunteer blood donors, the median concentration of crp was found to be ∼0.8 mg/l crp levels are useful as a clinical diagnostic tool for infection, and it is a common knowledge that itp is triggered by viral infection that precedes the clinical picture of itp by a few days to a few weeks procalcitonin (pct) is used as a reliable inflammatory biomarker with high sensitivity and specificity ferritin was confirmed as an inflammation and infection biomarker in the diagnosis of viral and bacterial infections.


Eligibility criteria:
inclusion criteria: * patients with platelet less than 100 × 109/l diagnosed as immune thrombocytopenia by bone marrow findings . age of patients : from 1 year to 50 years. exclusion criteria: * - other causes of thrombocytopenia as: * hypersplenism. * bone marrow diseases including : aplastic anemia, leukemia and myelodysplastic syndromes. * cancer treatments like chemotherapy and radiation therapy. * exposure to toxic chemicals as arsenic and benzene. * medications to treat bacterial infections (antibiotics)and treat seizures or blood thinner heparin.
intervention study in elderly with sleep problems

Conditions: Sleep Disturbance

Summary: the main objective of the study is to improve subjective sleep quality using a multimodal intervention with an intervention and a control group. the multimodal intervention aims to improve circadian zeitgeber strength. this will be achieved by optimizing daily light exposure, sleep, physical activity, and mealtimes.

the study lasts for 14 months and contains 6 visits. after the screening visit at the centre for chronobiology, basel, switzerland, participants are assigned to either the intervention or the control group which is followed by a 7-day baseline week at home and a co-design meeting to provide instructions to the intervention and the control group. at the occasion of 2 visits (spread over 6 months) at the participants' homes, different measurements will be performed such as saliva collection, questionnaires, cognitive performance tests, light and rest-activity measures. after the last visit at home, participants come for the second blood sample at the study centre. a follow-up visit 6 months after completion of the last data collection will provide qualitative feedback by the participants.

Eligibility criteria:
inclusion criteria: at least 65 years old women and men * pittsburgh sleep quality index (psqi) \> 5 (indicative of sleep problems) * living at home (including self-serviced retirement apartment) exclusion criteria: * total blindness or va \< 0.5 * progressive ncds (e.g., cancer) * acute infections (e.g., covid-19) * neurodegenerative disease * psychiatric disease * sleep disorder (sleep apnea, narcolepsy) * not german speaking

Keywords: circadian light cognition zeitgeber personalized health sleep muliti-modal
randomized crossover study of magnesium supplementation

Conditions: Diabetes Mellitus, Type 2; Inflammation

Summary: the investigators recent epidemiologic work in several national surveys and cohorts of men and women have shown that dietary patterns high in plant-based foods and phytochemicals are associated with lower plasma levels of insulin, triglycerides, and c-reactive protein, and reduced risk of type 2 dm and chd. while the physiologic impact of different foods on serum glucose and insulin is of critical importance, the extent to which specific dietary nutrients can modify insulin resistance is not well understood. magnesium is a biologically active constituent in whole-grain, green leafy vegetables, and nuts and appears to play an essential role in hundreds of physiologic processes in humans. however, it remains uncertain whether magnesium intake can exert effects on insulin sensitivity and inflammation. moreover, little is known of the extent to which magnesium intake elicits changes in the expression levels of key genes responsible for glucose homeostasis and systemic inflammation. the ultimate clinical question is whether magnesium supplementation would be clinically effective for the improvement of metabolic disorders in not yet diabetic but high-risk individuals, especially those who are susceptible to insulin resistance. therefore, as a direct follow up on our previous work in studying the health benefits of plant-based foods such as whole grains, fruits and vegetables, we propose a pilot randomized trial to unravel the metabolic and anti-inflammatory effects of magnesium supplementation versus placebo among overweight individuals with the metabolic syndrome who are particularly prone to the adverse effects of magnesium deficiency. recent advancements in molecular genetics and genomic technologies have also enabled us to analyze the expression levels of thousands of genes simultaneously in different experimental conditions. the application of high throughput microarray technology in randomized-controlled setting when analyzed with novel statistical methods, will not only help our understanding of nutrient-disease relations, but also afford the investigators the opportunity to gain important insight into the molecular mechanism for complex biological systems of inflammation, insulin resistance, and metabolic abnormalities in response to nutrition intervention.


Eligibility criteria:
inclusion criteria: * overweight individuals (with a bmi of ≥ 25 kg/m2) * between the ages of 30 and 70 years exclusion criteria: * concurrent documented cardiac, or renal disease as recorded by history of myocardial infarction or abnormal creatinine * history of known food allergy and/or dietary restriction * diabetes requiring insulin * pregnancy * diarrhea defined as watery stools more than 3 times a day for more than 3 days

Keywords: randomized controlled trial magnesium diabetes mellitus, type 2 inflammation
the effect of kinesio tape in chronic neck pain

Conditions: Chronic Neck Pain

Summary: this study was planned to investigate the efficacy of treatment for kinesio tape application in chronic neck pain individuals. a total of 44 individuals were randomly divided into two groups (study group: 22, control group: 22). conventional physiotherapy methods including active (exercise) and passive (hotpack, ultrasound and conventional transcutaneous electrical nerve stimulation (tens)) treatment were applied to all subjects for 15 sessions (5 days a week). in addition to the individuals in the study group, kinesio tape application was performed at the end of each session. pain (visual analogue scale), pressure pain threshold (digital algometer), range of motion (crom device), muscle strength (hand-held dynamometer), muscle endurance, pectoralis minor muscle length, quality of life (nottingham health profile) and depressive symptoms (beck depression scale) assessments were performed before treatment, on the second day of treatment and after treatment (after three weeks). treatment satisfaction with individuals (visual analogue scale) was assessed on the 2nd day of treatment and post-treatment (after three weeks).

in the literature, it is seen that kinesio tape is used in problems such as knee pain, chronic low back pain, neck pain, shoulder pain and common musculoskeletal pain. some studies with individuals with low back and neck pain show positive effects of kinesio tape on pain reduction and recovery in disability. however, studies are reporting the opposite of these results. the number of studies in the literature is insufficient to create clinical evidence regarding the use of kinesio tape in patients with neck pain. by considering this deficiency, the purpose of our study was to investigate the effect of kinesio tape applied together with conventional physiotherapy methods in individuals with chronic neck pain.

Eligibility criteria:
inclusion criteria: * being between the ages of 30-55, * having been suffering from neck pain for at least three months, * getting at least 5 points from the neck disability index, * having pain between the superior nuchal line and spina scapula, * neck pain task force, which consists of four levels to be at the first and second level. exclusion criteria: * presence of conditions that will prevent evaluation or communication (such as cognitive problems), * being illiterate, * having had physiotherapy from the neck, back or waist region in the last six months, * having had cervical region and spine surgery, * presence of impingement or thoracic outlet syndrome, malignancy, fractured, systemic autoimmune diseases, neurological problems and diagnosed psychiatric diseases that will prevent evaluation and treatment.

Keywords: neck pain kinesio tape pain quality of life
treatment for borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: this study will expose patients to either a systems training for emotional predictability and problem solving (stepps) or treatment as usual (tau) to determine the more effective therapy for treating borderline personality disorder.

participants are randomly assigned to receive either systems training for emotional predictability and problem solving (stepps) or treatment as usual (tau) for 20 weeks. stepps is a new cognitive behavioral treatment which involves skills training for emotion management and lifestyle behaviors as well as education for the affected individual's family members, friends, and professional caregivers. participants are assessed at baseline and weeks 4, 8, 12, 16, and 20. interviews of patient's health care providers and family members and self-rating scales are used to assess patients. follow-up assessments are made 1, 3, 6, 9, and 12 months after study completion. participants must live within a reasonable driving distance of iowa city, ia.

Eligibility criteria:
inclusion criteria: * borderline personality disorder
observation of the efficacy and tolerance of motens® (lacidipine) in patients with essential hypertension

Conditions: Hypertension

Summary: study of the efficacy and tolerance of motens® (lacidipine) in patients with essential hypertension. to obtain information on the dosage used in practice and the tolerance at the start of treatment (12 weeks)


Eligibility criteria:
inclusion criteria: non-hospitalised patients of both sexes aged 18 years or more with essential hypertension requiring treatment according to the recommendations of the german league for hypertension exclusion criteria: patients who had the contraindications listed in the product information (the case report file contained a copy of the product information)