Kornimate/medical-research-clean huggingface dataset:
multimodal exercise training to reduce frailty in people with multiple sclerosis

Conditions: Multiple Sclerosis; Frailty

Summary: study significance: this proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with ms. the proposed research will be the first to establish the feasibility of targeting frailty in pwms and will begin to examine the dynamic nature of frailty in ms. these advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in ms.


Eligibility criteria:
inclusion criteria: * subjects must be aged 40-65 years old to be enrolled in this study. * subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered. * subjects must have a confirmed diagnosis of ms by the treating neurologist * be free from ms relapses in the last 30 days * have an expanded disability status scale (edss) score ≤ 6.0 * be fluent in spoken and written english. exclusion criteria: * unable to walk unassisted for at least ten meters * are diagnosed with other clinically important neurological conditions (such as parkinson's disease, epilepsy, etc.) * exhibit severe cognitive impairment (as determined by a mini-cog score \<3) * are diagnosed with active psychiatric problems. * unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis) * arthritis of the lower limbs * acute lower back or lower limbs pain * rheumatic and/or severe orthopedic problems that may interfere with resistance training.
respiratory therapy and newborn pain: comparison between techniques

Conditions: Newborn Pain; Respiratory Therapy Techniques

Summary: this study intend to assess the pain intensity of newborns in neonatal intensive care unit (nicu) undergoing different techniques of respiratory therapy and compare these procedures. a randomized controlled clinical trial and blind trial with newborns admitted to nicu. the babies were categorized according to gestational age , age, weight, diagnosis, support and signs of respiratory distress. then, they were allocated by lot to come from one of 3 groups: g1 - control, g2 - undergoing physical therapy; g3 - received the thoracoabdominal rebalancing. each newborn received just one physical therapy session in that they were assessed before one of the three procedures (t1), immediately after (t2) and after 15 minutes (t3). this evaluation found cardiorespiratory parameters (oxygen saturation, heart and respiratory rate) and three specific scales for pain assessment (nips, nfcs and pipp). the hypothesis is that newborns hospitalized in intensive care unit did not show pain when undergoing respiratory therapy.


Eligibility criteria:
inclusion criteria: * newborns up to 28 days with any weight and gestational age in ventilatory support or oxygen therapy and clinical indication for physical therapy. exclusion criteria: * newborns with contraindication of respiratory therapy, those that had problems during any of the study procedures and changes in those suffering from respiratory support or oxygen therapy during data collection. * if there was failure to collect any of the parameters for evaluating the newborn also was no longer part of the sample.

Keywords: newborn pain respiratory physiotherapy neonatal intensive care unit
assessment of cai in adults with pws.

Conditions: Central Adrenal Insufficiency; Prader-Willi Syndrome

Summary: introduction: the prevalence and clinical significance of central adrenal insufficiency (cai) in adult patients with prader willi syndrome (pws) remains unclear. aim: to assess the prevalence of cai in adults with pws and to analyse the effects of replacement therapy with hydrocortisone (hct) in patients with suspected cai. material and methods: twenty one adult patients with pws were evaluated. based on peak cortisol at the 30 minute of the high dose short synacthen test (hdsst), patients were divided into three groups: cai (central adrenal insufficiency) - peak cortisol \<500nmol/l, intermediate (partial ai) - peak cortisol ≥500 nmol/l and \<600 nmol/l and as (adrenal sufficiency) - peak cortisol ≥ 600 nmol/l. in patients with diagnosed cai hct replacement treatment was initiated. body weight, body fat percentage, signs, and symptoms of cai were evaluated after 6 and 12 months of treatment.


Eligibility criteria:
inclusion criteria: * pws * age \>=18 years exclusion criteria: * age \<18 years * gc treatment at last 6 months
effects of dietary interventions on the brain in mild cognitive impairment (mci)

Conditions: Mild Cognitive Impairment

Summary: the study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.

the age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as alzheimer's disease are a growing public-health concern with devastating effects. referring to animal data, empirical studies, and pilot human trials, dietary modification (caloric restriction, omega-3 fatty acids and resveratrol) should improve cognitive functions such as learning and memory. to test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with mild cognitive impairment.

Eligibility criteria:
inclusion criteria: * subjects with mild cognitive impairment * 50-80 years old * moderate to heavy weight (bmi 25-35) exclusion criteria: * dementia * diabetes * severe disease * younger than 50 years * bmi \< 25

Keywords: memory diet elderly cognition prevention lifestyle
incidence of recall after procedural sedation with propofol in the emergency department

Conditions: Fractures Reduction; Joint Dislocation Reduction

Summary: the purpose of this study is to determine the incidence of recall in patients managed in emergency department with a procedural sedation protocol using propofol in a population of 250 .

after procedural sedation for fracture or joint dislocation reduction using propofol, adult patients recall will be assessed with a standardised form. this recall assessment will be realised 2 hours (+/- 15 minutes) after the procedural sedation and the day after. the primary outcome measure will be the recall incidence 2 hours (+/- 15 minutes) after a procedural sedation. a secondary outcome will be the recall incidence one day after the procedural sedation. the recall will be defined by a positive answer to the third question of the sandin form (lancet. 2000;355(9205):707-11).

Eligibility criteria:
inclusion criteria: * adults patients (\> 18 years old) who had a procedural sedation in emergency department using propofol for fracture or joint dislocation reduction * patients who received an initial injection of propofol by slow intravenous injection of 1 mg/kg in 20 seconds * inclusion less than 2 hours from the injection of propofol * patients who have signed a consent to participate in the study * patients covered by social security. exclusion criteria: * patients under 18 years old * patients who cannot signed the informed consent * patients who had procedural sedation using other drugs that propofol * participation in another study type biomedical research

Keywords: procedural sedation emergency department adults propofol recall assessment
patient and parent preferences for an on-body automated insulin delivery system

Conditions: Diabetes Mellitus, Type 1

Summary: the goal of this study is to learn more about patient and family preferences regarding use of advanced diabetes technologies. young persons with type 1 diabetes (ages 8-25) and parents of young persons with type 1 diabetes will complete one study visit involving a semi-structured interview and surveys. the results of the study will be used to assist in the design of a new automated insulin delivery system.

type 1 diabetes remains the most common chronic disease of childhood and affects millions of children and adults globally. the minority of persons with type 1 diabetes achieve the recommended glycemic targets. currently approved and unapproved automated insulin delivery systems require patients to carry and wear multiple devices (pumps, tubing, blood glucose meters, mobile devices, etc.). there is a need to design automated insulin delivery systems that reduce the burden of diabetes management for young persons and their families in an effort to improve glycemic control as well as other biomedical and psychosocial outcomes. the purpose of this study is to conduct separate semi-structured interviews with young persons with type 1 diabetes and parents of youth with type 1 diabetes (not necessarily the parents of the youth participants) regarding their preferences for an automated, on-body insulin delivery system. youth and parents will also complete short surveys related to perceived burden of diabetes self-care, quality of life, acceptance of diabetes, and worries about hypoglycemia. the feedback received from the interviews and surveys will help inform the design of a new on-body automated insulin delivery system.

Eligibility criteria:
inclusion criteria: * young persons (ages 8-25 years) with type 1 diabetes for 1 year or longer * parents of young persons with type 1 diabetes exclusion criteria: * none

Keywords: artificial pancreas pediatric parents adherence
singulair(r) in asthma and allergic rhinitis (0476-383)

Conditions: Asthma

Summary: effectiveness of adding montelukast to inhaled corticosteroids in adult subjects with both uncontrolled asthma and allergic rhinitis.


Eligibility criteria:
inclusion criteria: * patient is a user of inhaled corticosteroid (ics) or ics/long-acting beta 2-agonist (ics/laba) at any dosage * peak expiratory flow is \> or = 80% of predicted value on the day of visit 1 * uncontrolled as per canadian asthma consensus guidelines exclusion criteria: * unwilling to stop regular use of histamine h1 antagonists for allergic rhinitis symptoms * unwilling to stop use of antihistamine eye drops or cromoglycate eye drops or ophthalmic corticosteroid
laser versus vitrectomy versus intravitreal triamcinolone injection for diabetic macular edema

Conditions: Diabetic Macular Edema; Diabetes

Summary: macular edema is the main cause of vision loss in diabetic patients. its treatment is mainly based on laser photocoagulation, but has limited results. alternative treatment are under investigation, such as vitrectomy and intravitreal injections of triamcinolone .the aim of vitrilase is to compare the efficacy of these two treatments to laser photocoagulation for diabetic macular edema.

it is a randomized study with three arms * vitrectomy * repeat intravitreal triamcinolone injections * laser photocoagulation

Eligibility criteria:
inclusion criteria: 1. patient with type 1 or type 2 diabetes 2. visual acuity (va) : 0.1≤ va \< 0.5 (35 ≤ etdrs score \< 70) 3. patient with diffuse diabetic macular edema , as defined by :§ retinal thickening involving the center of the macular on biomicroscopy§ and diffuse leakage on fluorescein angiography . 4. macular thickness in the central area 1000 µm in diameter ³ 300 µm. 5. patient with :· either diffuse diabetic macular edema · or combined diffuse and focal diabetic macular edema with persistent diffuse macular edema 6 months after laser treatment of the focal edema . 6. systolic blood pressure ≤ 160 mmhg and diastolic blood pressure ≤ 90 mmhg., 7. hba1c \< 10%. exclusion criteria: 1. patient with tractional diabetic macular edema, as defined by· a taut, thickened posterior hyaloid on biomicroscopy and/or· a thickened , highly reflective posterior hyaloid on oct , partially detached from the posterior pole, and exerting a traction on the macula 2. active proliferative diabetic retinopathy (etdrs stage 61 or more severe) 3. structural damage to the center of the macula in the study eye likely to preclude improvement in visual acuity following the resolution of macular edema, including atrophy of the retinal pigment epithelium, subretinal fibrosis, laser scar(s), or organized central hard exudate plaque³ 1 disk area 4. hypertensive retinopathy 5. epiretinal membrane. 6. rubeosis irides . 7. patient requiring immediate panretinal photocoagulation or panretinal photocoagulation performed within the past 6 months . 8. history of chronic glaucoma in the study eye 9. history of elevated intraocular pressure ≥30 mm hg and/or alteration of visual field 10. concomitant therapy with systemic or topical ocular corticosteroids within the last 15 days . 11. cataract surgery in the study eye within the past 6 months, yttrium-aluminum-garnet (yag) laser capsulotomy within the past 6 months, 12. aphakia 13. patient with pseudophakic macula edema 14. unstable medical status including glycemic control and blood pressure. patients in poor glycemic control who, within the last 4 months, initiated intensive insulin treatment (a pump or multiple daily injections) should not be enrolled. 15. chronic renal failure 16. pregnant or nursing (lactating) women

Keywords: diabetes macular edema optical coherence tomography vitrectomylaser therapy intravitreal triamcinolone injection
prospective comparative study between ultrasound-guided quadratus lumborum block versus fascia iliaca compartment block for postoperative pain and cognitive dysfunction management in patient undergoing hip surgery

Conditions: Pain and Cognitive Dysfunction Management in Hip Surgery

Summary: hip fractures are more common in older people due to osteoporosis. it is estimated that around six million patients worldwide will suffer hip fractures annually by 2050 as the population ages \[1\]. clinically, hip surgery is a common and effective treatment for hip fractures. there will be an increasing number of older people undergoing hip surgery, including osteosynthesis and arthroplasty. however, severe surgical trauma, postoperative pain, and postoperative cognitive dysfunction (pocd) can be a considerable challenge for older people undergoing hip surgery \[2, 3\].the successful use of qlb with all approaches has been reported in case reports for the following surgical procedures: proctosigmoidectomy, hip surgery, above-knee amputation, abdominal hernia repair, breast reconstruction, colostomy, closure, radical nephrectomy, lower extremity vascular surgery, total hip arthroplasty, laparotomy, and colectomy. ultrasound-guided quadratus lumborum block (qlb) is a recently described fascial plane block in which the anesthetic is injected adjacently to the quadratus lumborum (ql) muscle with the goal of anesthetizing the nerves in the thoracolumbar region \[17,18\]. as a trunk nerve block, quadratus lumborum block (qlb) has been widely used for postoperative analgesia in patients undergoing abdominal and lower limb surgeries \[19\]. qlb can provide adequate analgesia and reduce opioid requirements after hip surgery \[20\]ficb or fascia iliaca block (fib), first proposed in 1989, is a means ofblocking the three principal lumbar plexus nerves of the thigh with a single injection of local anesthetic delivered immediately dorsal to the fascia iliaca \[21,22\]. indications of ficb are surgical anesthesia to the lower extremity, management of cancer pain and pain owing to inflammatory conditions of the lumbar plexus, and amelioration of acute pain following trauma, fracture, and burn \[23\]. fascia iliaca block (fib), which is widely used for postoperative analgesia in hip surgery, is a nerve block technique with proven efficacy\[24\].


Eligibility criteria:
inclusion criteria: age \> 65 years asa 1 , asa 2 montreal cognitive assessment (moca) score ≥ 26 before surgery scheduled for hip surgery exclusion criteria: patient refusal history of chronic pain or daily use of analgesics history of psychiatric disorder or inability to understand the consent form or how to use a visual analog scale (vas) for pain measurement inability to communicate appropriately allergy to any required drugs alcohol abuse local infection at the injection site contraindications to neuraxial anesthesia long-term use of antidepressants or narcotic analgesics
cryotherapy effectiveness in individuals with end stage knee osteoarthritis - a case series

Conditions: Osteoarthritis, Knee

Summary: the purpose of this case series will be to provide a detailed description of a standardized short-term cryotherapy application protocol using validated functional outcome measures in individuals with end stage koa

there are no studies determining the efficacy of cryotherapy in pain, function and quality of life for patients with end stage knee osteoarthritis (koa). this case series describes a standardized treatment program for end stage patients with koa and outcomes over a 12-week period.

Eligibility criteria:
inclusion criteria: * diagnosed with knee osteoarthritis based on clinical and radiographic criteria of american college of rheumatology * osteoarthritis signals in at least one of the compartments of the knee joint (tibiofemoral and / or the patellofemoral joint) * do not perform regular physical activity * grade 4 according to the criteria of kellgren \& lawrence knee osteoarthritis radiographic examination scale. * minimum score of 4 cm in visual analogue scale (total 10 cm) * body mass index less or equal to 40 kg/cm2 exclusion criteria: * physical therapy within 3 months prior to the research project * corticosteroid or hyaluronic acid injection in the knee (in the previous 6 months) * cardiorespiratory, neurological or other rheumatic dysfunctions associated with the diagnosis of knee osteoarthritis. * hip, knee or ankle surgery * any other type of chronic condition that can lead to pain.

Keywords: osteoarthritis, knee cryotherapy physiotherapy physical agent
polymyalgia rheumatica associated to primary sjogren syndrome

Conditions: Polymyalgia Rheumatica; Sjogren's Syndrome

Summary: to determine the phenotype of patients having pmr symptoms and primary sjogren syndrome (pss), we used a french national call to identify patients combining both diseases and collected retrospective clinical and biological data.

a national call to identify patients combining pss and pmr was disseminated in france. patients with sjögren's syndrome associated with rheumatoid arthritis were excluded. we described the global population having both diseases and compared them to two historic prospective cohorts of isolated pss (the prospective cohort of primary sjögren diapss), or isolated pmr (tenor, a cohort of recent pmr), regarding clinical, imaging and treatments characteristics.

Eligibility criteria:
inclusion criteria: * fulfilling the acr/eular 2012 criteria for pmr and the acr/eular 2016 criteria for pss exclusion criteria: -
assessment and rehabilitation of social cognition in people with traumatic brain injury

Conditions: Head Injury Trauma; Cognition Disorder

Summary: patients who have suffered moderate to severe traumatic brain injury (tbi) frequently develop behavioural changes, which can have deleterious consequences on interpersonal relationships, social, family and professional reintegration. they are a source of difficulties (burden) for family and friends. social cognition covers four functions: recognition of social cues; empathy; attribution of intentions to a third party, or theory of mind; and adjustment of social behaviour according to context. this study has two parts: 1/ evaluation, using a cognitive approach, of the different components of social cognition after moderate to severe traumatic brain injury, and of its repercussions in daily life and on family and friends. 2/ creation of a specific re-education method for the different modules of social cognition and study of its effectiveness.

first objective: to study in a systematic way in the same group of tbi patients the different domains of social cognition and the relationships between these different sub-domains in these patients, as well as the relationships between these deficits and the more global cognitive functioning (executive functions), and to evaluate their repercussions in daily life (activity limitations and participation restrictions). second objective: to develop and evaluate the effectiveness of a specific rehabilitation protocol for social cognition, adjusted to each profile, according to the disorders of the components of social cognition found in each patient. we make the hypothesis that not all patients will present homogeneous deficits and we also wish to bring elements of knowledge on the sub-domains of social cognition that can be "mobilized" by therapeutic means based on cognitive training adapted to each patient. the methodology envisaged is based on an experimental methodology in single repeated case studies, allowing a fine analysis of the architecture of the altered cognitive processes in a given patient and to adapt the rehabilitation protocol in an individualized way.

Eligibility criteria:
inclusion criteria: * male or female of legal age, * having suffered a moderate to severe traumatic brain injury (glasgow coma scale score of 3 to 12) at least 6 months after the trauma, * returned home at least 3 months ago, * having given their informed consent, * affiliated to the social security system exclusion criteria: * psychiatric history, * persistent post-traumatic amnesia, * instrumental disorders that interfere with taking tests (aphasia, agnosia, neurovisual disorders), * mood disorders not stabilized under treatment, * patient refuses to participate in the study, * participation in another cognitive rehabiltation protocol, * pregnant or breastfeeding woman.
exploration of hiv reservoirs

Conditions: HIV-1 Infection

Summary: prospective study in hiv-1 infected patients with a plasma viral load below the limit of detection and stable for at least 5 years.

evaluation of the mucosal hiv reservoirs (hiv-dna quantification and distribution of the infected t lymphocytes in the gut mucosa associated lymphoid tissue compared to the blood in hiv-1 infected patients under antiretroviral treatment with an undetectable plasma viral load below the 50 copies/ml limit of detection for at least 5 years).

Eligibility criteria:
inclusion criteria: * hiv-1 documented infection * hiv-1 plasma viral load measurable before antiretroviral treatment initiation * patients treated with an antiretroviral combination containing a protease inhibitor and/or a non-nucleosidic reverse transcriptase inhibitor without any interruption since treatment initiation * patients with a stable plasma viral load below the limit of detection (hiv-rna \< 50 copies/ml since january 2006 and/or hiv-rna \< 200 copies/ml during the anterior period) under antiretroviral treatment for at least 5 years and for at least 90 % of the measures exclusion criteria: * contraindication to the biopsy * no ability or willingness to provide informed consent * concomitant treatment with antithrombotics or platelets antiaggregatory * patients co-infected with hcv and or hbv * patients who received an immunosuppressive treatment during 3 months prior enrollment (chemotherapy, radiotherapy, corticotherapy, splenectomy) or an immunotherapy during 5 years prior enrolment (il-2, anti-hiv vaccine, ifn-alpha)

Keywords: hiv viral reservoirs viral load