Kornimate/medical-research-clean huggingface dataset:
healing touch or guided imagery in treating pain, fatigue, nausea, and anxiety in patients undergoing chemotherapy

Conditions: Anxiety Disorder; Fatigue; Malignant Neoplasm; Nausea and Vomiting; Pain

Summary: this randomized clinical trial studies healing touch or guided imagery in treating pain, fatigue, nausea, and anxiety in patients undergoing chemotherapy. healing touch and guided imagery may help treat complications caused by chemotherapy. it is not yet known whether healing touch or guided imagery is more effective in treating pain, fatigue, nausea, and anxiety in patients undergoing chemotherapy

primary objectives: i. to determine if the provision of healing touch or guided imagery during outpatient chemotherapy is associated with decreased pain, fatigue, nausea and anxiety when compared to standard outpatient treatment protocols. outline: patients are randomized to 1 of 3 treatment arms. arm a: patients receive 30 minutes of healing touch therapy comprising magnetic clearing, pain drains, hands in motion/hands still and mind clearing. arm b: patients listen to guided imagery audiotapes for 30 minutes arm c: patients receive standard of care.

Eligibility criteria:
inclusion criteria: * adult patients at the outpatient chemotherapy area will be enrolled without consideration for type of cancer or chemotherapeutic agents to be used
performance of aspheric hydrogel lenses after a refit with sphere silicone hydrogel lenses for 4 weeks

Conditions: Ametropia

Summary: the aim of this prospective study is to evaluate the clinical performance of habitual wearers of methafilcon a aspheric lenses after a refit with fanfilcon a sphere lenses for 4 weeks of daily wear.


Eligibility criteria:
inclusion criteria: * is between 18 and 40 years of age (inclusive) * has had a self-reported visual exam in the last two years * is an adapted soft contact lens wearer * has a contact lens spherical prescription between - 0.25 to - 8.00 (inclusive) * have no less than -0.75d (diopter) of astigmatism in both eyes * can achieve best corrected spectacle distance visual acuity of 20/25 (0.10 logmar) or better in each eye. * can achieve a distance visual acuity of 20/30 (0.18 logmar) or better in each eye with the study contact lenses. * has clear corneas and no active ocular disease * has read, understood and signed the information consent letter * patient contact lens refraction should fit within the available parameters of the study lenses * is willing to comply with the wear schedule (at least 5 days per week, \>8 hours/day assuming there are no contraindications for doing so) * is willing to comply with the visit schedule exclusion criteria: * has a contact lens (cl) prescription outside the range of the available parameters of the study lenses * has a spectacle cylinder of ≥ 1.00d (diopter) in either eye * has a history of not achieving comfortable contact lens (cl) wear (5 days per week; \> 8 hours/day) * has contact lens best corrected distance vision worse than 20/25 (0.10 logmar) in either eye * presence of clinically significant (grade 2-4) anterior segment abnormalities * presence of ocular or systemic disease or need of medications which might interfere with contact lens wear * slit lamp findings that would contraindicate contact lens wear such as: * pathological dry eye or associated findings * pterygium, pinguecula, or corneal scars within the visual axis * neovascularization \> 0.75 mm in from of the limbus * giant papillary conjunctivitis (gcp) worse than grade 1 * anterior uveitis or iritis (past or present) * seborrheic eczema, seborrheic conjunctivitis * history of corneal ulcers or fungal infections * poor personal hygiene
exercise intervention for the prevention of prediabetes in overweight chinese

Conditions: PreDiabetes; Insulin Sensitivity

Summary: overweight/obese chinese and prediabetes will be recruited and divided into three age-matched groups including high intensity exercise, moderate intensity exercise, and non-exercise groups. the exercise program will consist of three sessions per week over the course of 12 weeks, under the supervision of our in-house exercise specialists and physiologists. the effects of exercise on glucose and lipid profiles, insulin sensitivity and adiposity will be evaluated.

60 chinese men aged between 21 and 60 years old with overweight/obesity (25 kg/m2 \<bmi \< 32.5 kg/m2) and prediabetes will be recruited.the participants will be divided into three age-matched groups (n=20 in each group),including high intensity exercise, moderate intensity exercise, and non-exercise groups. the suitability of each participant for physical exercise will be assessed by an in-house exercise specialist, based on parameters of blood pressure, strength, cardiovascular fitness, balance, flexibility. the exercise program will consist of three sessions per week over the course of 12 weeks, under the supervision of our in-house exercise specialists and physiologists. each session will comprise of warm-up, resistance and aerobic training components and a cool-down. the high intensity training (aerobic combined with strength training) will consist of six exercises of three sets each, with each exercise set at an intensity of 6 to 10 repetition maximum. intensity, volume and exercise selection will be varied both within the week and over the 12 week program in a periodised system designed to maximize muscle hypertrophy and strength gain. exercise intensity will be at 60 to 80% of estimated heart rate maximum. moderate intensity training (aerobic training) will be conducted on a variety of ergometers including treadmill, cycle, rowing and cross training machines. the non-exercise group (delayed group) will be used as placebo control, and will participate in the training group at the later stage.

Eligibility criteria:
inclusion criteria: - overweight/obese chinese man (25 kg/m2\<bmi\<32.5 kg/m2) aged between 21 and 60 years old; prediabetes, impaired glucose tolerance (mean 2-h blood glucose ≥7.8 and ≤11.1 mmol/l after a 75-g oral glucose challenge) or impaired fasting glucose (mean fasting blood glucose ≥6.1 mmol/l and ≤7.0 mmol/l and hba1c levels between 5.7% and 6.4%). exclusion criteria: - any neurological, musculoskeletal or cardio respiratory condition, which would put them at risk during exercise or inhibit their ability to adapt to an exercise program; any subject participated in a regular vigorous exercise and/or diet program more than 2 times per week in the 3 months prior to recruitment; any subject who is taking medicine, especially antibiotics in the past week prior to study.
piezo-icsi to improve the developmental potential of fertilized oocytes in aged infertility women with assisted reproductive technology

Conditions: Infertility, Female; Intracytoplasmic Sperm Injections

Summary: the goal of this clinical trial is to test piezo-icsi on improving oocyte fertilization and embryo development in elderly infertile patients undergoing intracytoplasmic sperm injection (icsi). the main question it aims to answer is whether piezo-icsi could improve oocyte fertilization and embryo development. participants requested icsi are asked to randomly culture equal numbers of oocyte and embryo with or without piezo-icsi. at the time of injection, two or more mature oocytes were split into two groups (i) conventional icsi and (ii) piezo-icsi (50:50 split).

after being informed about the study and potential risks, all participants will write the informed contents. this study is a randomized controlled study compare different icsi methods on the fertilization and embryo development. sibling oocytes were randomly divided into test group (piezo-icsi) and control group (conventional icsi). specific method of randomization: all the oocytes of each subject were distributed into two dishes (dish 1 and dish 2). if the oocyte number is odd, put the extra oocyte into dish 1. using statistical software, the two dishes were randomly treated as test group and control group. thus, a random allocation table was generated and a separate random envelope was made for each subject. the random envelope is kept and distributed by the relevant personnel who are not involved in the screening and treatment of subjects and are authorized by the researcher. each selected subject must open the random envelope. the subjects were subjected to routine ovulation promotion, and then the acquired oocytes and cumulus cell complexes (cocs) were obtained and fertilized in vitro. the test group oocytes were fertilized with piezo-icsi, while the control oocytes were fertilized with conventional icsi. thus, half of the oocytes from each elderly infertile patient were treated with piezo-icsi.

Eligibility criteria:
inclusion criteria: 1. 35 years ≤ age ≤ 42 years; 2. number of ivf/icsi cycles ≤ 2 exclusion criteria: 1. egg donor cycle 2. chromosome abnormality; 3. adenomyosis, hysteromyoma, thin endometrium, endometriosis and other uterine diseases; 4. patients with repeated implantation failure
creatine supplementation in autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is accompanied by reduced levels of total creatine in right temporal-parietal junction and other brain regions of interest, and addressing this deficit by exogenous administration of creatine may have beneficial effects on brain metabolism and disease-specific clinical symptoms in patients suffering from asd.


Eligibility criteria:
inclusion criteria: * age 10 years and above * informed consent signed by a parent or legal guardian or legal representative * diagnostic and statistical manual of mental disorders-iv criteria for asd. exclusion criteria: * pregnant or nursing female patients * non-pharmacologic therapy * current diagnosis of other mental disorder
hybrid apc therapy in early central lung neoplasms

Conditions: Lung Neoplasms

Summary: 1.1 aims：this cohort study aims to investigate the clinical value of hybrid apc for treatment of early central lung neoplasms. 1.2 methods：a total of 30 patients with early central lung neoplasms will be included in this open, multicenter, prospective study. primary observation endpoint is recorded at 3 months follow-up, and after 3 months patients could be continued to follow up. the data are expressed in terms of mean and percentage. the categorical variables are analyzed by chi-square test, and the four table data is analyzed using the exact probability method. the continuous variable analysis is used by t test. statistical analysis is performed with spss 20.0 software. p \< 0.05 is considered statistically significant.

this is a prospective, multicenter, and cohort study. study subjects: patients with early central lung neoplasms meet inclusion/exclusion criteria and could receive interventional therapy. there are 3 study site in this study and a total of 30 patients with early central lung cancer will be included. hybridapc is integrated with traditional apc and water-jet technique, which has been successfully applied for endoscopic treatment of mucosal lesions in gi, such as barrett esophageal and lesions in colon. submucosal injection of water jet can elevate superficial lesion, and then apc can be more effective in ablation of superficial tumor with a protection for muscular layer. the application of hybridapc in respiratory intervention could theoretically protect cartilage, adventitia, reduce damage and formation of scare, and increase ablation energy to reach radical treatment.

Eligibility criteria:
inclusion criteria: 1. bronchoscopy and fluorescence bronchoscopy found endoluminal growth lesions of upper segmental bronchus. afb indicates malignant possibility. 2. size ≤ 20 mm 3. flat, nodule or polypoid type 4. negative imaging: hrct indicates no tumor in lung and lymph node enlargement; or pet-ct finds no lesions in lung or suspicious lymph node tumors involve. 5. clinical stage: tis or t1n0m0 6. high-grade intraepithelial neoplasia (including severe atypical dysplasia and carcinoma in situ) mucoepidermoid carcinomaand ,squamous cancer and etc. confirmed by biopsy histopathology 7. high-frequency ebus indicates the depth of lesions is cartilage endomembrane or internal part of adventitia of tracheal membranous part 8. patients are not suitable for surgery or refuse surgery 9. inform consent is available exclusion criteria: 1. patients with severe cardiopulmonary dysfunction or other contraindication can not tolerate endoscopic examination and treatment 2. severe bleeding tendency 3. poor compliance 4. unstable vital signs 5. investigators consider subjects should not be included because of specific situations

Keywords: hybrid apc,early central lung neoplasms,
a study of bevacizumab added to trastuzumab plus docetaxel in the neoadjuvant setting in participants with early stage her2-positive breast cancer

Conditions: Breast Cancer

Summary: this randomized study will assess the effect of adding bevacizumab to trastuzumab plus docetaxel in neoadjuvant therapy in participants with early stage human epidermal growth factor receptor 2 (her2)-positive breast cancer. after 2 cycles of trastuzumab and docetaxel once every 3 weeks, participants with a response (change in standard uptake value \[suv\]) of less than (\ /=) 70% will receive trastuzumab plus docetaxel in cycles 3 to 6. all participants will receive trastuzumab alone in cycle 7, and will undergo surgery (as per investigator's discretion) after cycle 7 and between 4 and 6 weeks after the treatment perfusion of cycle 6. after surgery, all participants will receive a further 11 cycles of trastuzumab plus radiotherapy (starting from 4-8 weeks after surgery during 4-6 weeks, according to site's standard practice) with or without hormonal therapy (mandatory if positive hormone receptors). participants will be followed for up to 5 years from start of neoadjuvant treatment.


Eligibility criteria:
inclusion criteria: * participants with early stage her2-positive breast cancer * scheduled to receive neoadjuvant therapy with the objective of conservative surgery * eastern cooperative oncology group (ecog) performance status 0, 1 or 2 exclusion criteria: * participants with partial or total lobular carcinoma * participants with inflammatory breast cancer * previous treatment with chemotherapy, radiation therapy or hormonal therapy for breast cancer * previous history of cancer (other than curatively treated basal and squamous cell carcinoma of the skin and/or in situ carcinoma of the cervix) relapsing within the 5 years before study entry or in situ contralateral breast carcinoma
the inflammatory response to stress and angiogenesis in liver resection

Conditions: Liver Cancer; Colorectal Cancer; Metastatic Cancer; Liver Metastases

Summary: patients with resectable liver metastases of colorectal origin will be assigned to laparoscopic liver resection or conventional open liver surgery. blood samples will be drawn preoperatively and 24 hours after resection. determination of interleukin-6 (il-6) and il-8 will be done to assess the stress response between open and laparoscopic liver resection (elisa test). the messenger ribonucleic acid (mrna) of inflammation related factors (cyclooxygenase-2 (cox-2) and matrix metalloproteinase (mmp-9)), angiogenesis related factor (vascular endothelial growth factor (vegf) and hypoxia induced factor-1 (hif-1)) in tumor tissue and normal liver parenchyma will be detected by real-time real time-polymerase chain reaction (rt-pcr).

according to the null hypothesis, no difference in the il6 postoperative value, between the two groups would be expected. to calculate sample size, a il6 postoperative value of 100±40 pg/ml in the laparoscopic group and 60±40 ml/m pg/ml in the open group was hypothesized. considering a two-sided α=0.05 and β=0.1, the minimal sample size required to achieve statistical significance was 17 subjects in both groups in a 1:1 randomization. laparoscopic group was increased by 20% of patients considering a conversion rate of 20% accordingly. randomization will be performed using computer-generated random numbers the day before operation and stopped when 20 patients per group will be reached.

Eligibility criteria:
inclusion criteria: 1. 18-80 years old 2. patients with colorectal liver metastases 3. colorectal liver metastases ≤10 cm in size - exclusion criteria: 1. patients not fit for laparoscopic surgery due to comorbidities 2. patients with tumors close or infiltrating the major vessels -
peroral endoscopic myotomy (poem) for the treatment of achalasia

Conditions: Achalasia

Summary: this is a pilot study for a new endoscopic treatment of achalasia. up to 25 patients will be recruited for this trial, with the intent to treat 20 patients.

this is a pilot study for a new endoscopic treatment of achalasia. up to 25 patients will be recruited for this trial, with the intent to treat or attempt to treat 20 patients. patients for whom a poem has been attempted but not completed (conversion to open or laparoscopic surgery, poem surgery aborted and not re-attempted). patients who proceed to study treatment will undergo ten years of follow-up as part of this study.

Eligibility criteria:
inclusion criteria: * diagnosis of achalasia * age 16-80 * asa class 1-3 exclusion criteria: * pregnancy * any prior surgical or endoscopic treatment for achalasia -- first eight subjects. after eight subjects have been treated as part of this study, this exclusion criteria no longer applies * patients who are taking immunosuppressive medications or are immunocompromised * patients on anticoagulant medications or abnormal coagulation tests * patients with severe medical comorbidities, in the judgment of the treating surgeon

Keywords: achalasia poem peroral endoscopic myotomy myotomy heller myotomy
histoacryl: a study of its efficacy in final scar formation

Conditions: Surgical Incisions

Summary: the use of tissue adhesives for the closure of surgical incisions is becoming increasingly common. several publications exist purporting the equivalence of tissue adhesive to suture with regard to dehiscence, infection, and cosmesis. two of the most frequently used adhesives are histoacryl© and dermabond©. despite their popularity, only one study exists comparing the two. in this non-english study only small wounds in an exclusively pediatric population were studied (12). operative time, cost, and objective measures of scar size were not examined. in the present study we aim to evaluate the relatively large surgical incisions resulting from breast reduction, mastopexy, panniculectomy, and abdominoplasty closed with either histoacryl©, dermabond©, or subcuticular suture. the primary aim is to investigate differences in time to wound closure. secondary aims are to compare the three approaches with respect to cost, dehiscence, infection, scar size, and cosmesis.


Eligibility criteria:
inclusion criteria: * age: younger than 21 * gender: females only. given the nature of the procedures, as well as our clinical experience, we cannot anticipate recruiting enough male patients to be able to evaluate them as a subgroup. since there may be differences in distributions of measures, to keep the groups more homogeneous we plan to recruit only females from the outset. having either: * reduction mammoplasty or mastopexy patients: * patients who present to the plastic surgery clinic and are scheduled for breast procedures will be recruited and consented by a clinical studies co-ordinator. * this will include patients undergoing a standard wise pattern reduction mammoplasty (reduction and lift) or a standard wise pattern mastopexy (lift only). see exclusion criteria below. * abdominoplasty or panniculectomy patients: * patients who present to the plastic surgery clinic and are scheduled for abdominal procedures will be recruited and consented by a clinical studies coordinator. see exclusion criteria below. exclusion criteria: * though women of childbearing age will be allowed to participate in this study, no pregnant patients will be enrolled. * patients with any factors that may have an adverse effect on wound healing: * previous hypertrophic scars or keloid * known vitamin c deficiency * known zinc deficiency * smoking * steroid use * known connective tissue disorder * hypoalbuminemia * any factor not listed that the attending consultant seeing the patient feels would adversely effect wound healing. * patients who have a known sensitivity to adhesives

Keywords: histoacryl closure of surgical incisions
administration of ons based on purple sweet potato in head and neck cancer patients with radiotherapy

Conditions: Oral Nutritional Supplement

Summary: the goal of this clinical trial is to compare the effect of local food-based oral nutritional supplements (ons) containing immunonutrients (omega-3 and anthocyanins) on nutritional status and inflammatory response in head and neck cancer patients receiving radiotherapy. the main questions it aims to answer are: * is there any effect of local food-based oral nutritional supplements (ons) containing immunonutrients (omega-3 and anthocyanins) on the nutritional status? * is there any effect of local food-based oral nutritional supplements (ons) containing immunonutrients (omega-3 and anthocyanins) on inflammatory response? participants will participants will receive ons in powder form ready to brew as much as 2 servings per day for 3 weeks. researchers will compare the effect of giving ons containing immunonutrients compared to standard ons to see the effect on nutritional status and inflammatory response

the intervention group received ons which contained immunonutrients with a composition consisting of purple sweet potato flour, egg white flour, whey protein, olive oil, omega 3 powder, sugar, and creamer. while the control group received a placebo in the form of standard ons (isocaloric) with a composition of powdered skim milk, coconut oil, sugar, maltodextrin, and creamer.

Eligibility criteria:
inclusion criteria: 1. participant diagnosed with advanced stage head and neck cancer (stages 3 and 4) who received radiotherapy, both as concurrent and adjuvant or chemoradiotherapy 2. participant aged 18-80 years 3. participant can consume food, either through a nasogastric tube (ngt) or orally exclusion criteria: 1. participant has a milk or egg allergy 2. participant with comorbid renal impairment and/or diabetes mellitus 3. participant with poor nutritional status with bmi \< 17.0 kg/m2

Keywords: oral nutritional supplement immunonutrient head and neck cancer radiotherapy purple sweet potato
an open label, safety study to assess the potential for adrenal suppression

Conditions: Plaque Psoriasis

Summary: an open label, safety study to assess the potential for adrenal suppression following treatment with dsxs (taro pharmaceuticals u.s.a., inc.) in patients with plaque psoriasis

to evaluate the potential of dsxs to suppress hpa axis function in patients with mild to moderate plaque psoriasis. to evaluate the efficacy parameters and adverse event (ae) profile of dsxs administered to patients with mild to moderate plaque psoriasis.

Eligibility criteria:
inclusion criteria: * male or non pregnant, non lactating females exclusion criteria: * patients under 2 years of age
sabina international

Conditions: Asthma

Summary: the aim of the study is to describe the prescribing pattern of the different types of medications which are used to treat asthma, across multiple countries.


Eligibility criteria:
inclusion criteria: 1. male and female patients ≥12 years-old 2. documented diagnosis with asthma as per medical records. 3. have had ≥3 consultations with the hcp at study start date 4. after full explanation, a patient or legal guardian must have signed an informed consent document indicating that they understand the purpose of and the procedures required for the study and are willing to participate in the study. exclusion criteria: 1. patient with a diagnosis of chronic obstructive pulmonary disease or other chronic respiratory disease different from asthma. 2. an acute or chronic condition that, in the investigator's opinion, would limit the patient's ability to participate in this study