gut kidney axis in enteric hyperoxaluria

Conditions: Enteric Hyperoxaluria

Summary: 40 subjects with a confirmed diagnosis of ibd or \>6 months post-rygb with a diagnosed usd event or kidney stone on imaging within the past three years and 40 healthy controls will be administered a high oxalate diet on days 0-3 and days 21-24 with a washout period on days 4-7 and will be administered 250mg sodium oxalate on days 8-20, via prepared spinach, from weil cornell medicine's clinical and translational science center. subjects will partake in four stool collections, four 24-h urine collections, two blood collections, and four sets of colonic permeability testing.


Eligibility criteria:
inclusion criteria: in order to be eligible to participate in this study, an individual must meet all of the following criteria: * subjects \> 18 years and \< 80 years of age * a confirmed diagnosis of ibd or \> 6 months post- rygb, with a diagnosis usd event (renal colic with spontaneous stone passage, emergency room visits, or urological interventions) or have kidney stone on imaging (ct, mri, or us) in the previous three years. * we will include all racial and ethnic groups, and both men and women. in order to be eligible in this study as a healthy control, an individual must meet all of the following criteria: * subjects \> 18 years and \< 80 years of age * healthy controls with no chronic diseases, not on any chronic medications, no history of gi pathology, or urinary stone disease (usd). * we will include all racial and ethnic groups, and both men and women. exclusion criteria: an individual who meets any of the following criteria will be excluded from participation in this study: * pregnant or nursing women and people with any medical, psychiatric, debilitating disease/disorder or social condition that, in the judgment of the investigator, would interfere with or serve as a contraindication to adherence to the study protocol, ability to give icf or complete the protocol. * subjects with total and partial colectomy. * subjects who received oral, intramuscular, or intravenous antibiotics within three months before screening. * patients with perianal disease usually receive recurrent antibiotics and, therefore, will be excluded from the study. * patients with an ongoing symptomatic ibd flare or a flare within the previous three months * patients with estimated glomerular filtration rates (egfr) \< 60 ml/min/1.73 m2 calculated by the ckd-epi equation measured anytime within the preceding year. an individual who meets any of the following criteria will be excluded from participation in this study as a healthy control: * pregnant or nursing women and people with any medical, psychiatric, debilitating disease/disorder or social condition that, in the judgment of the investigator, would interfere with or serve as a contraindication to adherence to the study protocol, ability to give icf or complete the protocol. * subjects with total and partial colectomy. * subjects who received oral, intramuscular, or intravenous antibiotics within three months before screening. * patients with perianal disease usually receive recurrent antibiotics and, therefore, will be excluded from the study. * patients with an ongoing symptomatic ibd flare or a flare within the previous three months * patients with estimated glomerular filtration rates (egfr) \< 60 ml/min/1.73 m2 calculated by the ckd-epi equation measured anytime within the preceding year.