Kornimate/medical-research-clean huggingface dataset:
intracoronary rhtnk-tpa versus tirofiban in patients with stemi and high thrombus burden

Conditions: ST-segment Elevation Myocardial Infarction (STEMI)

Summary: the goal of this clinical trial is to compare the efficacy and safety of intracoronary rhtnk-tpa or tirofiban in patients with st-segment elevation myocardial infarction and high thrombus burden. the main questions it aims to answer are: * is the efficacy of intracoronary rhtnk-tpa non-inferior to intracoronary tirofiban for the treatment of st-segment elevation myocardial infarction in patients wiht high thrombus burden? * does intracoronary rhtnk-tpa increase the incidence of bleeding events? this multicenter rct study plans to enroll 300 patients, who are randomly divided into two groups: intracoronary rhtnk-tpa or tirofiban by 1:1. the primary efficacy endpoint was post-pci corrected timi frame count (ctfc). major adverse events (death, recurrent myocardial infarction, ischemic stroke, or hospitalization for heart failure) were observed at 1 year follow-up.


Eligibility criteria:
inclusion criteria: * age 18-75 years old; * stemi within 12 hours of onset; * timi flow grade 0-2 or timi thrombus grade ≥4 after thrombus aspiration or balloon dilation * radial artery access exclusion criteria: * a functional coronary collateral supply (rentrop grade≥2) to the infarctrelated artery * known or suspected old myocardial infarction of target vessels * rescue pci * cardiogenic shock * contraindications to tirofiban or rhtnk-tpa * severe hepatic and renal insufficiency (alanine aminotransferase ≥5 upper limit of normal; estimated glomerular filtration rate \<30ml/min/1.73m2, or on dialysis) * prolonged (\> 10 minutes) cardiopulmonary resuscitation * definite mechanical complications (including ventricular septal perforation, or rupture of the papillary tendon bundle, or rupture of the left ventricular free wall) * severe chronic obstructive pulmonary disease or respiratory failure * severe infection * neurological disorders * malignant tumors or other pathophysiological conditions with an expected survival time of less than 1 year * pregnant or lactating women
effectiveness of exergames on cognitive, social functionamong chronic schizophrenia

Conditions: Gambling

Summary: an experimental study with random assignment will be adopted. the participants from 2 hospitals will be assigned to two groups: experimental group (n=77), and control group (n=77). experimental group, in addition to scheduled activities, will be provided with the "individual brain training exergames (a program for improving cognitive function and eye-hand coordination)" three times a week and 30 minutes each time. the control group will be maintained with their scheduled activities in daycare as usual. behavioral intentions, cognitive function, social function, and hand-eye coordination will be measured at 0, 3, 6, 9, 12 weeks.

in the first year, an experimental study with random assignment will be adopted. the participants from 2 hospitals will be assigned to two groups: experimental group (n=77), and control group (n=77). experimental group, in addition to scheduled activities, will be provided with the "individual brain training exergames (a program for improving cognitive function and eye-hand coordination)" three times a week and 30 minutes each time. the control group will be maintained with their scheduled activities in daycare as usual. behavioral intentions, cognitive function and hand-eye coordination will be measured at 0, 3, 6, 9, 12 weeks. in the second year, the investigators continue first year study, the experimental group will be provided with the "team cooperation training exergames (a new program for improving sugar control, cognitive and social function)" three times a week and 30 minutes each time. the control group will still be maintained with their scheduled activities in daycare as usual. cognitive and social function and related physiological indices (muscle mass, fasting blood sugar, glycosylated hemoglobin (hba1c) and reduction body fat will be measured before intervention and at 0, 3, 6, 9, 12 weeks. in the third year, in the first three months, the investigators will use the concept of "empowerment" to design a seed program for training 2-3 patients to be "exergame instructors". experimental group a will be provided with the "team cooperation exergames" three times a week and 30 minutes each time by research team. experimental group b will be provided with the "team cooperation exergames (teamwork and exercise)" three times a week and 30 minutes each time by "exergame seed ". the control group will be maintained with their scheduled activities in daycare as usual. cognitive and social function, and related physiological indices will be measured at 0 3, 6, 9, 12 weeks. the investigators expect this research project can improve the cognitive, social function and sugar control among chronic schizophrenia patients with diabetes mellitus, and the "exergames" can be extended.

Eligibility criteria:
inclusion criteria: * schizophrenia * aged 20-65 years exclusion criteria: * violence or suicidal behavior * dementia

Keywords: schizophrenia cognitive functions social function exergames sugar control
cmv igg antibodies in semen as a predictor for blood testis barrier damage

Conditions: Male Infertility

Summary: to assess whether the presence of cytomegalovirus (cmv) immunoglobulin g (igg) antibodies in semen is a reliable predictor of male subfertility or infertility.

prospective cohort study performed in the artificial reproductive technology (art) unit. the study will evaluate semen and serum samples from the following groups: 1. presumably fertile male patients going through art treatment (for preimplantation genetic testing (pgt) or female indications). 2. subfertile/infertile male patients with abnormal semen analysis. 3. male patients suffering from unexplained infertility. all samples will be collected on the day of ovum retrieval procedure, and the semen samples will be evaluated only after completing the fertilization process. the samples will be tested for cmv igg antibodies and testosterone levels in semen and serum. in addition, anti-sperm antibodies will be measured in the serum. the ratio between cmv igg antibodies in semen and serum will be calculated, and will be compared with presence of hormone profile, semen analysis parameters and art parameters.

Eligibility criteria:
inclusion criteria: * all male patients addressing the infertility unit in hadassah mt scopus for ivf procedure exclusion criteria: * refusal to participate * male partner utilizing pre cycle frozen sperm sample * donor sperm cycles * surgically retrieved sperm

Keywords: sperm blood testis barrier cmv antibody unexplained infertility
genetic risk factor for heat stroke

Conditions: Carrier State; Heat Stroke; Dehydration

Summary: the goal of this observational study is to examine the effect of the cystic fibrosis (cf) carrier state on the risk for dehydration and other cf-specific fluid-and-electrolyte disorders in male and female adults. the primary aim of the study is to estimate the risk of electrolyte disorders attributable to the cf carrier state in a genotyped cohort. this will be accomplished with two smaller projects- aim 1 and aim 2. aim 1 will consist of 100 cf carriers and 100 age- and sex-matched controls. participants in this aim will be asked to complete a participant info and temperature survey consisting of questions about race, ethnicity, medical history, and how they experience heat. aim 2 will consist of a subset of 25 cf carriers and 25 age- and sex-matched controls from aim 1. participants in this aim will be scheduled for a visit to complete a heat challenge. at this visit, they will also complete the participant info and temperature survey. they will also sit in a sauna at 62 - 63 degrees celsius for 45 minutes.


Eligibility criteria:
inclusion criteria: * previously genotyped as a cf carrier or control * comfortable speaking/reading english exclusion criteria: * previously genotyped as a cf patient * diagnosis of type 1 or type 2 diabetes * history of heart attack, stroke, heart failure, or atherosclerosis * currently pregnant * currently taking beta blockers or diuretics * prisoner status * unable to provide own written informed consent
iron dosing pilot study using model predictive control

Conditions: Renal Insufficiency, Chronic; Anemia, Iron Deficiency; Anemia of Chronic Kidney Disease

Summary: this is a pilot study to test the utility of an integrated approach in the management of the anemia of chronic kidney disease through the administration of both an erythropoietic stimulating agent and iron. subjects will be studied for 6 months during which all iron dosing will be recommended using a computer based tool using model predictive control. comparisons will be made to the 6 months prior to enrollment in to the study.


Eligibility criteria:
inclusion criteria: * chronic kidney disease * anemia * receiving intravenous iron exclusion criteria: * none
tms treatment for depression in the national health service

Conditions: Depression

Summary: this research programme purports to test the effectiveness of two transcranial magnetic stimulation (tms) protocols (repetitive high frequency protocol and theta burst protocol) in reducing the symptoms of depression. the study also uses magnetic resonance imaging (mri) scans to improve the localization of tms targets.


Eligibility criteria:
inclusion criteria: * diagnosis of depressive disorder (dsm-iv) * diagnosis of treatment resistance (at least stage 1 as defined by thase \& rush, 1997 for depression) * female or male between 18 and 70 years exclusion criteria: * history of bipolar disorder * clinically relevant neurological comorbidity such as brain neoplasm, cerebral vascular events, epilepsy, neurodegenerative disorders, prior brain surgery * metal objects in and around body that cannot be removed * pregnancy * cardiac pacemaker or implanted medication pump * major unstable medical illness * change in prescribed medication in the 2 weeks preceding the start of tms trial * current alcohol/stimulant dependence with propensity for toxic/withdrawal seizures

Keywords: transcranial magnetic stimulation neuronavigation magnetic resonance imaging
efficacy of a new type of mechanical rotational chair in treating bppv

Conditions: BPPV

Summary: a study to establish the efficacy of a new type of mechanical rotational chair in treating bppv. in addition, comparison of three types of treatment maneuvers using the mechanical rotational chair.

open-label, randomized controlled trial comparing three different treatment maneuvers in a mechanical rotational chair (rotundum-chair) in treating bppv. patients diagnosed with bppv will be randomized to one of three maneuvers in the rotundum-chair: 1. epley's maneuver 2. semont maneuver 3. 360 degree vertical rotation

Eligibility criteria:
inclusion criteria: * characteristic (for bppv) positional nystagmus * positive dix-hallpike test * medical history compatible with bppv exclusion criteria: * treatment in a mechanical rotational chair within the last 6 months * exclusion of bppv diagnosis * lack of treatment cooperation * known cerebral aneurism or cerebral hemorrhage * treated for bppv within the past month

Keywords: benign paroxysmal positional vertigo vertigo dizziness vestibular diseases epley maneuver semont maneuver repositioning chair
68ga-labeled ny104 pet imaging in patients

Conditions: Renal Cell Carcinoma

Summary: this is a single arm study to evaluate the safety and biodistribution of 68ga-labeled ny104 pet imaging in patients with renal cell carcinoma


Eligibility criteria:
inclusion criteria: 1. patients voluntarily signed informed consent; 2. age 18-75, male or female; 3. patients diagnosed with renal cell carcinoma confirmed by histopathology or cytology; 4. at least one measurable solid lesion has been examined according recist1.1 standard; 5. ecog score 0\~3; life expectancy of at least 3 months; exclusion criteria: 1. recovery from major trauma (including surgery) within 4 weeks prior to study treatment; 2. patients with systemic or locally severe infections, or other serious coexisting diseases; 3. patients with abnormal immune function or who have recently used immunosuppressive or potentiating agents including various vaccines; 4. patients with autoimmune diseases, including rheumatoid arthritis; 5. inadequate control of arrhythmias, including atrial fibrillation; 6. uncontrolled hypertension; 7. patients with allergies or allergies to any component of the imaging agent or antibody; 8. patients who cannot undergo pet/ct imaging scan; 9. syphilis, hbv, hcv, or hiv positive subjects; 10. male and female subjects of reproductive age cannot take effective contraceptive measures; 11. pregnant or lactating women; 12. patients with a history of mental illness or related conditions; 13. other subjects considered unsuitable by researchers.
the impact of infectious disease on qt segment

Conditions: Sepsis; Pneumonia; Cardiomyopathy, Secondary

Summary: sepsis related to the development of cardiac complications. however, the investigators understanding regarding this condition remains incomplete. possible explanations raised include coronary perfusion decrease, activation of the coagulation system and release of inflammatory mediators, including endotoxins, cytokines and others. in this study the investigators wanted to examine the impact of any infectious disease, (not necessarily pneumonia), on the qt interval in patients hospitalized for acute infectious disease.


Eligibility criteria:
inclusion criteria: * internal ward hospitalized patient, due to illness which its etiology is bacterial, fungal or viral exclusion criteria: * can not technically perform reliably ecg (amputated legs, lack of cooperation, etc.) * subject with permanent pacemaker
web-based treatment of heavy drinking among women with a history of sexual trauma

Conditions: Sexual Assault; Heavy Drinking

Summary: the goal of this study is to empirically evaluate a web-based intervention to reduce heavy drinking among college women with a history of sexual assault who display elevated levels of psychological distress. college women with a history of sexual assault often report more heavy drinking and psychological distress than women without a history of assault. moreover, women with assault histories often have difficulty regulating their emotions and tolerating distress which can lead to a pattern of drinking to cope distress. trauma exposure, negative mood, and poor coping strategies have been associated with poor treatment outcomes and relapse following alcohol treatment. incorporating distress tolerance and emotion regulation skills with an alcohol intervention may enhance treatment effects among women with a history of sexual assault by decreasing their motivation to drink to cope with depression or anxiety and by building adaptive coping strategies. therefore, the web-based intervention will include cognitive behavioral skills for reducing alcohol consumption and incorporate emotion regulation and distress tolerance skills from dialectical behavior therapy.

for the small randomized controlled trial, heavy drinking college women with a history of sexual assault will be recruited and randomized to receive the intervention or an assessment only control. online surveys will be administered at baseline, and post-treatment as well as 1-month and 6-months post-treatment.

Eligibility criteria:
inclusion criteria: * enrollment at the university of washington, * female, * 18 or older, * lifetime history of sexual assault (defined as unwanted attempted or completed oral, vaginal, or anal penetration but excluding unwanted sexual contact only), * at least 2 instances of heavy episodic drinking (defined as 4 or more drinks in 2 hours) in the past 30 days, * average consumption equal or greater than 7 drinks per week in the past 30 days. exclusion criteria: * none
repeated educational intervention for the prevention of diabetic foot ulcers in high-risk patients

Conditions: Diabetic Foot

Summary: following a prior observation that a brief structured group educational intervention is effective for the prevention of diabetic foot ulcers in high-risk patients, but that the efficacy decreases over the time, this study is designed to verify the effect of a repetition of the educational intervention.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * either diabetic neuropathy or previous foot ulcer exclusion criteria: * arteriopathy of lower limbs, with abi\<0.8 or needing revascularization
placental inflammation in prenatal care

Conditions: Preterm Birth

Summary: objective of study is to explore expression of stress-related genes and inflammation in placentas and umbilical cord blood for women participating in group prenatal care compared with women receiving individual prenatal care.

this study aims to evaluate levels of inflammatory markers and genetic indicators of stress an inflammation in the placentas and umbilical cord blood in pregnancies that undergo group prenatal care as compared to traditional prenatal care. the investigators know that women receiving group prenatal care have fewer spontaneous preterm deliveries. what is not known is the mechanism behind this difference. by collecting umbilical cord blood samples and placentas of 40 women at the time of delivery, the investigators hope to study expression of stress-related genes and levels of inflammatory markers at the maternal-fetal interface.

Eligibility criteria:
inclusion criteria: * age \>= 18 years * singleton pregnancy exclusion criteria: * presence of known fetal congenital anomalies (lethal anomaly or anomalies that may lead to early delivery or increased risk of neonatal death). * presence of known chromosomal abnormalities * progesterone treatment during the current pregnancy after 14 weeks * chronic corticosteroid (i.e. prednisone or other steroids) treatment during the current pregnancy (not including inhalers or topical)
impact of gastroesophageal reflux and aspiration on airway inflammation and microbiome in children with chronic cough

Conditions: Chronic Cough (CC); Gastroesophageal Reflux (GER)

Summary: using an active cohort of children in whom airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway sample obtained during the clinically indicated bronchoscopy for microbiome analysis. a case-control study design will be used to study whether subjects with cc with ger have a distinct lung microbiome and increased inflammation as compared with subjects with cc without ger and to determine whether the microbiome and degree of inflammation is related to the type of ger (acidic versus nonacidic).


Eligibility criteria:
inclusion criteria: * children (age 0 - 24 years) referred to the nyu pediatric aerodigestive center to evaluate for cc (\>4weeks). exclusion criteria: * antibiotic or steroids (inhaled or systemic) use within the prior one-week. rationale: antibacterial drugs and immune-modulators are confounders that may impact the microbiome and inflammation. while longer period free of antibacterial drugs and immune-modulators would be desired, it would be unethical and it is not the usual standard of care to withdraw treatment for longer periods of time. * interstitial lung disease or pneumonia on x-ray * cystic fibrosis * primary ciliary dyskinesia * immunodeficiency syndromes * major airway abnormalities * proton pump inhibitor/h2-receptor antagonist therapy within the prior 2 weeks
pridopidine's outcome on function in huntington disease, proof- hd

Conditions: Huntington Disease

Summary: this study will evaluate the efficacy and safety of pridopidine 45mg twice daily (bid) in patients with early stage manifest huntington disease (hd).

this is a phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of pridopidine 45 mg bid in patients with early stage hd.

Eligibility criteria:
inclusion criteria main study 1. diagnosis of hd based on clinical features and the presence of ≥36 cag repeats in the huntingtin gene 2. diagnostic confidence level (dcl) of 4 3. adult-onset hd with onset of signs and symptoms ≥18 years of age 4. stage 1 or stage 2 hd, defined as a uhdrs-tfc score of ≥7, at screening exclusion criteria 1. use of pridopidine within 12 months before the baseline visit. 2. gene therapy at any time 3. any serious medical condition or clinically significant laboratory, or vital sign abnormality that precludes the patient's safe participation in and completion of the study e.g. significant heart disease within 12 weeks before baseline or history of certain cardiac arrhythmias 4. history of epilepsy or seizures within the last 5 years 5. pregnant or breastfeeding, or intention to become pregnant during the study

Keywords: huntington disease
the effectiveness of low carbohydrate diet in reducing polypharmacy for patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: this study determines whether an educational intervention with a 90 g/day lcd is safe, effective and has good compliance for poorly controlled type 2 diabetes patients.

poorly controlled type 2 diabetic men and women, aged between 20 and 80 years, with hba1c≧ 7.5% (58mmol/mol) in the previous 3 months participated in this randomized controlled 18-month trial at a medical center. patients were randomly assigned to the interventional group and given a 90g/day low carbohydrate diet (lcd) or the controlled group, which maintained a standard calorie-restricted diet (crd). all patients received periodic educational intervention and were monitored for weight, body composition, waist girth, hip girth, thigh girth, pre- and post-prandial serum glucose, hba1c, lipid profile(cholesterol, triglyceride. hdl, ldl, sdldl), renal function, microalbumin/cre, carotid intima-media thickness (imt),and medication effect score (mes).

Eligibility criteria:
inclusion criteria: * type 2 diabetes diagnosis ≧ 1 year * poorly controlled with hba1c≧ 7.5% in the previous 3 months. * aged 20 to 80 * without or with treatment \[ oral hypoglycemic agents (oha) and/or insulin treatment) exclusion criteria: * pregnancy or lactating women * impaired renal function with serum creatinine ≧ 1.5 mg/dl * abnormal liver function \[alanine aminotransferase (alt), aspartate aminotransferase (ast), ≧ 3 times the normal upper limit) or liver cirrhosis * significant heart diseases (unstable angina, unstable heart failure) * frequent gout attacks (≧ 3 times/year) * participation in other weight loss programs or the use of weight-reducing drugs * eating disorders * could not complete the questionnaire * poor compliance to protocol.

Keywords: type 2 diabetes mellitus low carbohydrate diet