Kornimate/medical-research-clean huggingface dataset:
tdcs and vi to treat neuropathic pain and function in sci

Conditions: SCI - Spinal Cord Injury

Summary: transcranial direct current stimulation (tdcs) over the primary motor cortex (m1) will be applied for patient who suffer from neuropathic pain following spinal cord injury the tdcs treatment will be coupled with a video of a man walking (creating a visual illusion) in order to enhance functional ability and reduce pain

non-invasive cortical brain stimulation is a promising method for treating cases of neuropathic pain in patients with spinal cord injury (sci). transcranial direct current stimulation (tdcs) over the primary motor cortex (m1) appears to modulate cortical excitability and can reduce pain levels following sci, however its effects remaining for short-term and may not be useful for the rehabilitation progress in these patients. recent findings suggest that m1 stimulation combined with visual illusion (vi) enhances the reduction in pain which maintain up to 3 month following treatment. the current study aims to reveal whether reduction of neuropathic pain in patients with sci through tdcs have beneficial effect on functional ability during rehabilitation program. in the present study the investigators will use anodal stimulation of the m1 via neuroconn dc stimulator. current intensity of 2ma or sham stimulation will be given during 20 min in parallel to a visual illusion of walking legs (or neutral video for sham stimuli).

Eligibility criteria:
inclusion criteria: 1. patients hospitalized in spinal cord rehabilitation department 2. neuropathic pain following spinal cord injury 3. able to seat on a wheel chair 4. able to understand and comply with basic instructions 5. hebrew speakers exclusion criteria: 1. epilepsy 2. pregnancy 3. non-neuropathic pain 4. medical condition that affect cognitive functioning 5. medical condition other then the spinal cord injury that affect functioning

Keywords: tdcs (trans cranial direct current stimulation) visual illusion neuropathic pain spinal cord injury
study of peripheral arterial disease (pad) in people with cancer who will be having surgery

Conditions: Peripheral Arterial Disease (PAD) in Cancer Patients

Summary: researchers are studying whether people with risk factors for blood circulation disease have a condition called peripheral arterial disease (pad). people with pad have poor blood circulation because of narrowing or blocks in blood vessels caused by fat or calcium deposits (atherosclerosis). the study researchers think that pad may lead to worse outcomes in cancer treatment, but people with cancer are not routinely tested for the disease. the purpose of this study is to find out how common pad is among people with cancer who have risk factors for blood circulation disease, and to compare how often pad is diagnosed in different racial groups


Eligibility criteria:
inclusion criteria: * cancer patients who are ≥ 65 years old * either diabetes (on medication or insulin) or smoking history (current smoker, smoking within the last 15 years, ≥ 20 pack years) * patients who are scheduled for major head and neck, thoracic, abdominal, or pelvic surgery requiring at least a 2-day admission * ambulatory * ≥ 6 month life expectancy as determined based on clinical judgement by the treating physician. if treating clinician does not confirm life-expectancy ≥ 6 months, will calculate lee schoenberg index using eprognosis.ucsf.edu. exclusion criteria: * hospice patient, patient with a dnr order * non-ambulatory, wheelchair/bed bound * \< 6 month life expectancy based on the clinical judgement by the treating physician

Keywords: peripheral arterial disease (pad) cancer patients 22-326
vancomycin-associated acute kidney injury: a cross-sectional study from a multi- center in china

Conditions: Vancomycin; Staphylococcal Infections; Adverse Effect; Acute Kidney Injury; Cross-sectional Study

Summary: the objective of this study was to investigate the current situation of vancomycin (van)-associated acute kidney injury (va-aki) in china and identify the risk factors for va-aki, as well as to comprehensively examine the risk related to concurrent drug use. further, the investigators assessed the outcomes of patients who developed va-aki and the risk factors for these outcomes. finally, the investigators aimed to provide suggestions for improving the prevention and treatment of va-aki in china.


Eligibility criteria:
inclusion criteria: * using vancomycin * ≥18 years old exclusion criteria: * medical records were incomplete * had been diagnosed with stage 5 ckd or were regularly receiving dialysis * scr were not being adequately monitored to detect the development of aki * had undergone nephrectomy
promise women project

Conditions: Human Papilloma Virus; Cervical Cancer

Summary: the goal of this study is to develop and test an intervention program to improve cervical cancer prevention among muslim american women. the main questions the investigators aim to answer are: * will the religiously tailored and culturally appropriate intervention program improve participants' knowledge and acceptance of cervical cancer prevention? * is the intervention program feasible to conduct and acceptable to participants? participants will be asked to: * attend focus group sessions to provide input on the development of educational materials. * complete pre- and post-intervention surveys to measure changes in knowledge and acceptance of cervical cancer prevention. * engage in the intervention program, which includes education and experiential practice/communication skills training. * provide feedback through satisfaction surveys. researchers will compare participant outcomes before and after the intervention to assess its effectiveness. additionally, the program's feasibility and acceptability will be evaluated based on enrollment rates, successful implementation, participant engagement, retention, and satisfaction.

this project involves creating special educational materials for muslim women to learn about cervical cancer prevention. the investigators will engage in discussions with 10 muslim women during dedicated group sessions to ensure the suitability of the materials. they will also seek input from muslim religious leaders. subsequently, they will conduct surveys before and after the program to assess the effectiveness of the materials in facilitating women's learning and comprehension of cervical cancer prevention. to determine its efficacy and acceptability, the investigators will implement the program with an additional 20 women and gather their feedback. the goal of this project is to promote the health and well-being of muslim women by providing them with culturally and religiously sensitive information regarding cervical cancer prevention.

Eligibility criteria:
inclusion criteria: * inclusion criteria: * female muslim individuals above 18 years old. * able to speak and understand english. * have not had a hysterectomy. * have not had a cervical cancer diagnosis. * willing to participate in the educational program and undergo cervical cancer screening. * physically well, able to give consent form. exclusion criteria: * under age 18 * not muslim * unable to provide consent * participated in a pilot study

Keywords: screening vaccination muslim american women prevention health disparities acceptability and feasibility. behavioral intervention religious adaptation
turkish adaptation of the activity limitations in cerebral palsy questionnaire

Conditions: Activity, Motor; Cerebral Palsy; Limitation, Mobility

Summary: this study aimed to make the turkish adaptation of activlim-cp and to examine its psychometric properties. eighty-nine individuals with cp, aged between 2-18 years were included in the study. pedi̇, abiloco-kids, and abilhand-kids scores and wee-fim questionnaires were used for validity analysis. test re-test method was used for reliability.

cerebral palsy (cp) is a clinical picture with permanent disorders of the development of movement and posture whether assessing activity limitations matters. this study aimed to make the turkish adaptation of activlim-cp and to examine its psychometric properties. the internal consistency of the scale was evaluated using cronbach's alpha value and the inter-measurement reliability using the intraclass correlation coefficient (icc). in construct validity analysis; activlim-cp score; was correlated with pedi̇, abiloco-kids, and abilhand-kids scores and wee-fim total scores. a known group comparison was made according to ambulation and epilepsy existence with the principal components explanatory factor analysis.

Eligibility criteria:
inclusion criteria: * children with cp who were diagnosed by a child neurologist * having physical therapy sessions at special education and rehabilitation center * age between 2 and 18 exclusion criteria: * whose parent was illiterate or doesn't speak turkish * whose parent wasn't complete the questionnaires

Keywords: cerebral palsy limitation activity
think life, an online self-help intervention for coping with suicidal ideation

Conditions: Suicidal Ideation

Summary: the objective of the think life study is to test the effect of an online, unguided self-help intervention, i.e. think life. the primary hypothesis is that think life will reduce suicidal ideation. the secondary hypothesis is that think life will lead to improvements in depressive symptoms, hopelessness, rumination, and anxiety. positive changes are expected after completing think life and at follow-up, twelve weeks after baseline.


Eligibility criteria:
inclusion criteria: * 18 years or older * have internet access and an e-mail account exclusion criteria: * no suicidal thoughts (i.e. baseline score on beck scale for suicide ideation = 0)

Keywords: suicidal ideation suicide cognitive behavioral therapy online intervention
safety and tolerability of xmab®7195 in adult healthy volunteers and adult subjects with a history of allergic rhinitis and/or allergic conjunctivitis and/or atopic dermatitis

Conditions: Allergic Rhinitis; Allergic Conjunctivitis; Atopic Dermatitis

Summary: this first-in-human (fih) study is a randomized, double-blinded, placebo-controlled, ascending dose study to investigate the safety, tolerability, and pharmacokinetics of xmab7195 in adult healthy volunteers and in adult subjects with elevated ige levels.


Eligibility criteria:
inclusion criteria: * adult males and females 18 to 50 years of age * parts 1 and 3: healthy subjects with no clinically significant abnormality identified on medical or laboratory evaluation and no history of any clinically significant disorder, condition, or disease that would pose a risk to subject safety or interfere with the study evaluation, procedures, or completion; * part 2: otherwise healthy male and female subjects with a history of allergic rhinitis and/or allergic conjunctivitis and/or atopic dermatitis with an elevated serum ige * subjects who are able and willing to give written informed consent; * subjects who have the ability to complete all study assessments; * subjects who are willing to forego other forms of experimental treatment during the study. exclusion criteria: * subjects who have a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, hematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, connective tissue diseases, or disorders (other than allergic rhinitis and/or conjunctivitis and/or atopic dermatitis in part 2) that would pose a significant risk to subject safety or significantly interfere with the study evaluation, procedures, or completion * subjects who are positive for hepatitis b surface antigen (hbsag), hepatitis c virus (hcv) antibody and/or human immunodeficiency virus (hiv) type i or type ii tests at screening; * subjects who do not agree to use medically acceptable methods of contraception (as defined in the protocol); * subject is pregnant or breast feeding, or planning to become pregnant within 3 months of administration of xmab7195; * subjects who have used any investigational drug in any clinical trial within 8 weeks prior to admission (day -1), or have used an experimental monoclonal antibody; * subjects with prior exposure to a monoclonal antibody; * subjects with a history of anaphylaxis; * subjects who have received live vaccines ≤ 3 months from screening;
comparison of clomiphene citrate and gonadotropins in ovulation induction cycles

Conditions: Infertility

Summary: the purpose of the present study is to analyse prospectively if highly purified hmg compared with increased dose of clomiphene citrate has different outcomes in folliculogenesis in ovulation induction cycles.


Eligibility criteria:
inclusion criteria: * \< 39 years old on day of randomisation * fsh \< 12 (in the early follicular phase) * normal ultrasound scan, i.e. presence of both ovaries, without evidence of abnormality within 6 months prior to randomisation. * chronic oligo or anovulation (who 2) * bmi between 18 and 31 (both inclusive) exclusion criteria: * ≥ 39 years old on day of randomisation

Keywords: ovulation induction clomiphene citrate gonadotropins
characteristic and real intensity of exercise in a hospital-based physical activity protocol for patients with chronic disease

Conditions: Physical Inactivity

Summary: the objective is to better characterize an adapted physical activity (apa) program within of the management of chronic diseases. in france, since 2016, medical doctors have been able to prescribe apa to their patients with chronic diseases but while there are indeed prescription recommendations, there is no clear characterization of the practical reality of apa programs. the interest of this work is to benefit from the experience of the center of sports medicine and adapted physical activities in nancy (france) specifically dedicated to the prescription and the initiation of an apa program for of patients with a chronic disease. thus, this work aims to determine the real intensity of the apa, the effectiveness of the assessment necessary for the dispensation of the apa and other parameters likely to modify the result of the treatment.


Eligibility criteria:
inclusion criteria: - age greater than 18 years old, with the ability to perform a cardiopulmonary exercise test exclusion criteria: * beta-blocker treatment.

Keywords: adapted physical activity chronic disease exercise
virtual reality for post operative pain

Conditions: Pain, Postoperative

Summary: randomized controlled trial to measure pain experience, side effects and satisfaction of vr following varicose vein, hernia repair and gallbladder surgeries.

while there is substantial evidence supporting the use of virtual reality (vr) during dressing changes for burn victims, there are little information of the effect of vr to decrease pain after surgery. although pharmacological analgesics are popular in clinical practice, this approach usually is associated with side effects, most commonly nausea, cognitive dysfunction, and constipation. generally, vr effects are based on gate theory of cognitive load, due to the fact that conscious attention is needed to perceive pain and we can process a finite amount of information.high-tech-vr devices shown to be more effective in reducing pain than are low-tech-vr systems (prothero, j. d., \& hoffman, h. d, 1995). in addition, studies have shown that interactivity play an important role to decrease both, pain unpleasantness and time spent thinking about pain, while increasing fun (wender, r., et al., 2010, gromala, d., et al 2011). thus, interactivity helps patients to have a better immersion into vr world. considering this, in the proposed study, patients will be randomized to either receive a high immersive and interactive vr environment using oculus rift headset in addition to standard care or to receive only standard care during their post-operative care following surgery to prospectively assess the utility of virtual reality (vr) for pain management following varicose vein, hernia repair and gallbladder surgeries.

Eligibility criteria:
inclusion criteria: * patient with varicose vein, hernia repair or gallbladder surgery * patient in the acute care units, 1-3 days following surgery. * willing and able to provide informed consent and participate in the study visit and study follow-up questionnaire. exclusion criteria: * non-romanian speaking patients. * age \> 18 years and \< 65 years. * patients with neoplastic pathologies. * patients with history of motion sickness. * patients with visual impairment. * patients with severe/profound cognitive impairments measured with six-item cognitive impairment test (6cit).
fluciclovine-pet/ct for bone metastases from prostate adenocarcinoma

Conditions: Prostate Adenocarcinoma

Summary: determine diagnostic accuracy of axumin-pet positive bone lesion by confirmatory bone biopsy.


Eligibility criteria:
inclusion criteria: 1. male 2. be ≥ 18 years of age 3. diagnosed with prostate cancer 4. be willing and able to provide informed consent 5. be informed of the investigational nature of this study exclusion criteria: 1. having a history of severe claustrophobia 2. weight exceeding 400lbs
church-based hiv screening: taking it to the pews

Conditions: HIV

Summary: the primary aim of this study is to fully test a culturally/religiously-tailored, church-based hiv screening intervention (tips) against a standard hiv information intervention on hiv screening rates at 6 and 12 months with adult african american church members and community members who use church outreach services. our secondary outcome is to reduce sexual risk behaviors with this same population.

the primary aim of this study is to fully test a culturally/religiously-tailored, church-based hiv screening intervention against a standard hiv information intervention on hiv screening rates at 6 and 12 months with adult aa church members and community members who use church outreach services. in this two-arm clustered, randomized community trial, churches will be matched on ses, membership size, and denomination, then randomized to treatment condition. it is projected that 14 churches (7 churches per arm; 110 church and community members per church; 1,540 participants total) will be required to detect significant increases in hiv screening in the intervention arm. intervention content is guided by the theory of planned behavior (tpb). intervention delivery will be guided by a community engagement and social-ecological approach. this approach includes church leaders delivering culturally/religiously-appropriate hiv education and screening materials (e.g., sermon guides, hiv screening testimonials, church bulletins) and activities (e.g., pastors modeling receipt of hiv screening, hiv screening events) from a church-based hiv tool kit through multilevel church outlets (community-wide, church-wide services, ministry and outreach groups, individual) to increase intervention reach and dosage. it was hypothesized that this church-based hiv screening intervention will significantly increase hiv screening rates vs a standard hiv information intervention in aa church-populations at 6 and 12 months. the role of potential mediators and moderators related to receipt of hiv screening will be evaluated and a process evaluation to determine modifiable implementation fidelity, facilitators, barriers, and costs related to increasing church-based hiv testing rates will be conducted. this intervention study could provide an effective, scalable model for hiv screening interventions in aa churches.

Eligibility criteria:
inclusion criteria: * all participants must be: aged 18 to 64; willing to participate in 3 surveys after church services or church outreach activities * willing to provide contact information (two phone numbers, mailing and email address, phone numbers for two persons with whom they have ongoing contact) * attend church at least once a month or use church outreach services, such as food and clothing programs, at least 4 times per year. exclusion criteria: * minors 18 and under are intentionally excluded since the intervention study has been designed specifically for adults with information of how hiv affects the african american adult population.

Keywords: hiv screening african american church
canadian hemophilia prophylaxis study

Conditions: Severe Hemophilia A

Summary: primary prophylaxis given less frequently initially, with the infusion frequency increased if needed (escalating dose prophylaxis), is likely to be less expensive and associated with fewer complications than standard prophylaxis while reducing disability to a greater degree than intermittent therapy.

there are 2 specific study objectives. the first is to estimate the incidence of target joint bleeding in patients with severe hemophilia a treated (for primary prophylaxis) with escalating dose prophylactic factor replacement. the second objective is to obtain accurate estimates of the direct and indirect costs associated with this protocol for use in a cost-effectiveness model (comparing escalating dose with standard prophylaxis and with intermittent therapy).

Eligibility criteria:
inclusion criteria: * severe hemophilia a (factor level less than 2%). * age greater than 1 year and less than or equal to 2.5 years. * normal joints using the world federation of hemophilia orthopedic scale. * normal radiographs of joints in which bleeding has occurred using the world federation of hemophilia radiographic scale. * platelet count of \> 150,000. * informed consent to participate. exclusion criteria: * three or more clinically determined bleeds into any single elbow, knee or ankle. * presence or past history of a circulating inhibitor (level ≥ 0.5 bethesda units). * family judged to be non-compliant by the local hemophilia clinic director. * competing risk (symptomatic hiv infection, juvenile rheumatoid arthritis, metabolic bone disease, or other diseases known to cause or mimic arthritis.)

Keywords: hemophilia, prophylaxis, cost effectiveness
bone mass and strength after kidney transplantation

Conditions: End Stage Renal Disease; Kidney Transplantation; Bone Loss; Fractures; Vascular Calcifications

Summary: the purpose of this study is to test whether active vitamin d (calcitriol) protects bones from weakening and protects blood vessels from calcium deposits over the first year of kidney transplantation.

kidney transplant recipients at highest fracture risk, as determined by epidemiologic studies (caucasians and older recipients). rocaltrol (calcitriol) is a synthetic vitamin d analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body.

Eligibility criteria:
inclusion criteria: * age older than 18 * self-describes as white race exclusion criteria: * lower extremity amputations * non-ambulatory * paget´s disease of bone * current hyperthyroidism, untreated hypothyroidism * medical diseases (end stage liver, intestinal malabsorption) * use within the prior year pod anti-seizure medications that induce the cytochrome p450 system, testosterone, estrogen, selective estrogen receptor modulators * weight \>300 pounds * dual organ transplant * myocardial infarction or stroke * tobacco use within the past year

Keywords: kidney transplantation calcitriol bone mineral density bone mass and strength vascular calcifications hyperparathyroidism parathyroid hormone