Kornimate/medical-research-clean huggingface dataset:
effect of cyp3a genetic polymorphisms on the pharmacokinetics of atorvastatin

Conditions: Coronary Heart Disease

Summary: the aim of the study is to investigate the effects of cyp3a polymorphisms on the pharmacokinetics of atorvastatin in chinese subjects with coronary heart disease.

large variability exists in the individual response to statins. cyp3a polymorphisms likely contribute to variable response to those drugs primarily metabolized by cyp3a including atorvastatin.

Eligibility criteria:
inclusion criteria: * subjects must demonstrate their willingness to participate in the study and comply with its procedures by signing a written informed consent. * subjects must be \>=35 years and \<=70 years of age. * subjects must have an ldl-c concentration \>=2.6 mmol/l and tc concentration \>=4.14 mmol/l * body mass index (bmi) must be within the range of 19 to 30 for patients. * subjects must have documented coronary heart disease with one or more of the following features: * documented stable angina (with evidence of ischemia on exercise testing) * history of myocardial infarction * history of percutaneous coronary intervention (with or without stent placement) * documented history of unstable angina or non-q wave myocardial infarction. exclusion criteria: * diabetes and endocrine or metabolic disease. * congestive heart failure defined by new york heart association (nyha) as class iii or iv. * uncontrolled cardiac arrhythmia. * uncontrolled hypertension (systolic bp \>160 mm hg and/or diastolic bp \>100 mmhg on two consecutive measurements). * liver or kidney disease confirmed by abnormal lab values or function. * smokers who report cigarette use of more then 10 cigarette per day. * subjects who consume \>2 alcoholic drinks a day. (a drink is: a can of beer, glass of wine, or single measure of spirits). * known human immunodeficiency virus (hiv) positive. * cancer. * subjects who are on any of the following concomitant medications: * medications that are potent inhibitors of cyp3a, including cyclosporine, itraconazole, fluconazole, and ketoconazole, erythromycin or clarithromycin, nefazodone, protease inhibitors,mibefradil and large amounts of grapefruit juice (\>1 quart/day). * lipid-lowering agent: niacin (\>200 mg/day) taken within 5 weeks, fibric acid derivatives taken within 8 weeks.

Keywords: atorvastatin genetic polymorphisms coronary heart disease pharmacokinetics cyp3a
multi-site trial using sms to improve infant weight

Conditions: Obesity

Summary: the goals of this multi-site clinical trial are to pilot test weekly sms sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the women, infants and children (wic) program in puerto rico and hawaii. the intervention consists of weekly sms for 4 months to reinforce the feeding messages provided by wic.

the goals of this multi-site clinical trial are to pilot test weekly sms sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the wic program in two distinct locations, puerto rico and hawaii; to assess acceptability and practicality of the intervention; and to assess acceptability of collecting blood spots in future studies. the investigators will recruit a convenience sample of parent/caregivers of infants 0-2 months participating in the wic program in puerto rico and hawaii to send weekly sms for 4 months. the weekly messages will focus on reinforcing the breastfeeding messages provided by wic, preventing overfeeding, delaying introduction of solid foods, and delaying and reducing baby juice consumption, which are key issues in low-income populations. participants will complete validated questionnaires and anthropometry before and after the trial and results will be compared to the control group (no messages). participants will also answer short questions by sms at different points and an interview at the end of the trial to assess the sms. the investigators will assess how many participants agree to collect blood spots in their infants in future studies.

Eligibility criteria:
inclusion criteria: * caregiver age 18 years and older * owner of a mobile phone with unrestricted sms capability * responsible for the care of the infant and willing to actively participate for the full duration of the study. exclusion criteria: * infants with special diets * infants with limited mobility * pre-term birth (\<37 weeks) * small or large for gestational age (birthweight \ 90th p) * inability to consent to participate in the study * unwillingness to be randomized and not being able to read

Keywords: infants minorities overfeeding wic program feeding practices breastfeeding
the proton pump inhibitor (ppi) test for the extraesophageal manifestation of gerd

Conditions: Gastroesophageal Reflux Disease

Summary: ppi test;empirical trial with high-dose proton-pump inhibitors (ppis) has been shown to be a sensitive tool for diagnosing patients with gerd. however, this diagnostic strategy has not been well established in patients with extraesophageal manifestation of gerd. in this study, we aim to see the relevance of ppi test in diagnosing gerd in patients with extraesophageal symptoms.


Eligibility criteria:
inclusion criteria: * patients with extraesophageal manifestation symptoms of gerd exclusion criteria: * laryngeal, pharyngeal, liver, lung, renal, or hematological disorders * a history of gastrointestinal surgery, and a history of connective tissue disorders. * patients with duodenal or gastric ulcers as well as other significant lesions, such as gastric cancer, esophageal cancer, or subepithelial tumors more than 1 cm observed on the upper endoscopy

Keywords: patients with extraesophageal manifestation of gastroesophageal reflux disease
total lifestyle reconstruction for body weight control and maintenance

Conditions: Overweight and Obesity

Summary: obesity stands as a significant health concern of the 21st century. the prevalence of obesity is steadily rising worldwide, and taiwan is no exception, with nearly four to five out of ten individuals facing issues of overweight or obesity. additionally, approximately 1.5% of adults suffer from morbid obesity. presently, lifestyle interventions focusing on body control have shown limited success in maintaining an ideal weight and body composition, and they are predominantly applied within clinical settings for managing morbidly obese patients. in response to the transformations brought about by the 3c era in connecting with the public, an effective online intervention approach holds promising potential but still requires development and validation. this project endeavors to revolve around "cultivating a healthy lifestyle" by creating educational materials on weight reduction. these materials will encompass various aspects such as dietary habits, physical activity, and daily routines, all designed to impart online lifestyle education. to facilitate the intervention, the investigators plan to employ the application "cofit" developed by the cofit healthcare inc., targeting individuals with weight reduction needs. furthermore, the investigators aim to collect research data for the analysis of intervention effectiveness. over a three to six-month intervention period, the research participants will receive multifaceted lifestyle education through the online app. certified nutritionists, trained under the program, will interact with the participants online, guiding them to make changes in their diet, physical activity, and daily routines. the ultimate goal is to help the participants achieve effective weight reduction and maintain a healthy body weight in the long term.


Eligibility criteria:
inclusion criteria: * bmi between 24 and 35 exclusion criteria: * cancer * hospitalization * pregnancy * depression * currently taking weight loss drugs * unwilling to give up meal replacement for weight loss * unable to cooperate with the data collection and intervention guide of this study * stage iii kidney disease or above * diabetes * taking medication * participation in previous weight loss courses of qunjian technology company
the effects of mindfulness-based stress reduction program for family or caregivers of children with motor disabilities

Conditions: Stress, Psychological; Stress, Emotional; Stress

Summary: the present study aims to investigate the effect of a mindfulness-based program on perceived stress, severity of anxiety, parents'/caregivers' quality of life and their children, cortisol and il-6 blood concentrations.


Eligibility criteria:
inclusion criteria: * not having attended previously a mindfulness course * a score equal to or greater than 23 points at the pss. * \>18 years old * children \<18y with motor/physical disability due to a neurological disorder. * spanish/catalan speaking exclusion criteria: * currently using drugs or any kind of medication related to stress, depression, anxiety or sleeping pills, such as steroid medicines. * regular meditation practice (once a week in the past 12 months) * diagnose of hypertension stage 2 * pregnancy in the case of mothers * present hyperthyroidism * primary adrenal insufficiency syndromes such as cushing syndrome or addison disease * present any kind of infection or inflammation process, different from the interestingly to the present study that could differ the results
the effectiveness of applying multimedia on self-care and quality of life in patient with enterostomy

Conditions: Multimedia Learning Education; Self-care; Quality of Life; Enterostomy

Summary: this report was an effective evaluation of using multimedia educational program for self-care and quality of life in patients with a stoma at postoperative and established a simple threshold for enterostomy self-care skills.

in a systematic review, evaluated the effectiveness of multimedia education program (mlep) and confirmed that mlep reduced cost significantly and improved patient participation in enterostomy care and self-care ability. however, research was insufficient for whether a multimedia education program (mlep) interventions can improve patient self-care and quality of life.

Eligibility criteria:
inclusion criteria: * age ≧ 20 * operation with ostomy exclusion criteria: * dementia, mental illness, and central nervous system diseases * unable self-care * visual or hearing impairs
first clinical evaluation of hearo robotic cochlear implantation surgery in austria

Conditions: Deafness

Summary: to demonstrate the efficacy of a minimally invasive direct cochlear access via the hearo procedure in cochlear implantation.

the hearo procedure involves a robot which drills the access to the cochlear in cochlear implantation. the study is an observational study of the first implementation in clinical routine in austria.

Eligibility criteria:
inclusion criteria: * adult cochlear implant candidates with suitable anatomy opting for a med-el cochlear implant. exclusion criteria: * age under 18 years * pregnant women * facial recess size does not allow a minimum distance of 0.4mm from the planned trajectory to the facial nerve and 0.3mm to the chorda tympani * vulnerable or mentally retarded candidates * invalid or withdrawn informed consent

Keywords: cochlear implantation robotic surgery automated inner ear access automated middle ear access
the combination therapy of nanofat grafting and prp compared with microfat grafting and prp synergy in treating striae distensae

Conditions: Treatments of Striae Distensae

Summary: striae distensae is caused by the fracture and damage of the elastic fibers and collagen fibers, which is still a difficulty to overcome. based on the studies demonstrated that platelet-rich plasma(prp) has positive effect on superficial scar, and nanofat and microfat are effective in treating atrophic scar. so in this clinical trial, the investigators are going to treat striae distensae by using two combination therapies. one is nanofat grafting and prp injection synergy, and the other one is treated by microfat grafting with prp injection.

the participants were randomly assigned into two groups. group a is treated by nanofat grafting once every three months for 2 times combined with prp injection once a month for 6 times. group b will be treated by microfat grafting onceevery three months for 2 times combined with prp injection once a month for 6 times. the participants were asked to come back 1、3、6、9 months after treatment for further follow-up.before and after the treatment, the striae distensae will be assessed subjectively by satisfaction assessment, and objectively by ultrasound and immunohistochemical analysis.

Eligibility criteria:
inclusion criteria: * the striae distensae * age ≤ 35 years old exclusion criteria: * skin allergy * cicatricial diathesis * skin inflammation or wound * platelet dysfunction syndrome * take anticoagulant drugs * acute or chronic infection * chronic liver disease * active vitiligo, psoriasis, systemic lupus erythematosus

Keywords: striae distensae platelet-rich plasma (prp) nanofat graft microfat graft combination therapy
adaptive servo-ventilation in "real life" conditions : the otrlasv study

Conditions: Chronic Heart Failure and; Complex Sleep Apnea Syndrome; Obstructive Sleep Apnea Syndrome and; Idiopathic Central Sleep Apnea Syndrome; Idiopathic Induced Periodic Breathing; Central Sleep Apnea Syndrome

Summary: adaptive servo-ventilation (asv) treatment is routinely prescribed in france. in order to be reimbursed according to the french social security rules, the patient treated with an asv needs to be examined each year. in this observational transversal single-visit study, the investigators aim to describe the clinical characteristics of patients treated with asv and the associated device settings.

the purpose of this study is to evaluate in "real life conditions" the use of adaptative servo-ventilation (asv) treatment. asv treatment is routinely prescribed in france in patients with various sleep disorders breathing (chronic heart failure (chf) and central sleep apnea syndrome (csas), chf and central and obstructive sleep apnea (cosa), obstructive sleep apnea syndrome (osas) and complex sleep apnea syndrome (compsas), idiopathic or drug induced periodic breathing. in order to be reimbursed according to the french social security rules, the patient treated with an asv needs to be examined each year. in this observational transversal single-visit study, the aim is to describe the clinical characteristics of patients treated with asv and the associated device settings. the aim is to evaluate the safety and efficacy issues in real life conditions of the asv prescription.depending of the data, data are obtained after analysis of the six latest months data of the asv device, after questioning the patient, after analysis of the polygraphy/oximetry (if prescribed by the doctor for the renewal consultation of the asv care and reimbursement by the french social security). all the data are obtained during the annual consultation required by the french social security.

Eligibility criteria:
inclusion criteria: * written informed consent * age more than 18 years (inclusive) * patient treated with asv for at least one year,and eligible for care and for the reimbursement by the french social security rules. * patient presenting at the annual control consultation for the continuation of the asv treatment according to the french social security rules. exclusion criteria: * pregnancy, intention of being pregnant, breastfeeding. * inability to understand the nature and aims of the study or to communicate with the investigator * simultaneous participation in another trial with an exclusion clause to participate to an other trial. * no affiliation to the french social security * loss of personal capacity resulting in state protection * deprivation of liberty by judicial or administrative decision

Keywords: adaptive servo-ventilation chronic heart failure central sleep apnea syndrome central and obstructive sleep apnea syndrome complex sleep apnea syndrome hunter-cheyne-stokes breathing periodic breathing
pain severity in fibromyalgia syndrome

Conditions: Fibromyalgia; Pain, Chronic

Summary: fibromyalgia syndrome (fms) is a complex syndrome that mainly includes the musculoskeletal system and is characterized by many symptoms such as chronic widespread pain, fatigue and sleep disorders, cognitive dysfunctions, regional pain syndrome, psychiatric disorders. the existence and importance of the multidimensional nature of chronic pain in fms has been demonstrated. factors such as pain intensity, persistence of pain, pain-related disability, and novelty of onset are all important characteristics of a chronic pain condition. therefore, there was a need for a global measure of chronic pain severity that summarized different measures of pain and a graded classification of chronic pain was proposed. patients with chronic pain such as fms are known to have a greater negative impact than many chronic medical conditions. chronic pain severity in fms has been found to be associated with various conditions such as function and health status, and it has been shown that reduction in pain severity provides broadly beneficial results on these conditions. however; there are no studies in which chronic pain severity in fms is classified by grading and investigating the relationship of different pain severity degrees with disease severity and other symptoms. the aim of this study is to evaluate whether the severity of the disease, kinesiophobia, and concerns about pain differ in individuals with different pain severity by grading the severity of pain in individuals with fibromyalgia syndrome.


Eligibility criteria:
inclusion criteria: * to be aged between 18-65, * to be diagnosed with fibromyalgia syndrome according to the criteria of 2016 acr * to be volunteer to participate in the study. exclusion criteria: * having cognitive impairment * illiterate people * diagnosed severe mental and psychological disorders

Keywords: fibromyalgia pain patient reported outcome measurement
investigation of the effect of specially designed insoles for flat-footed patients

Conditions: Flat Foot [Pes Planus] (Acquired), Unspecified Foot

Summary: in our study, it was aimed to investigate the effect of insoles specially designed for each patient and printed with 3d printers on the physical activity levels, balance and functional performances of those patients.

our study, b.a.i̇.b.ü. i̇zzet baysal physical therapy training and research hospital and fizyotermal corp. it will be carried out as a dual center on individuals between the ages of 18-45 who apply to our clinic. it will be carried out by selecting 48 people who are suitable for the study among the flat-footed patients who applied to the clinics. patients will be evaluated before they start using the insoles, and immediately after using it , also after wearing the insoles for 8 weeks. patients will be randomized according to the order of their arrival at the clinic.

Eligibility criteria:
inclusion criteria: * 1. having a minimum 5 degree subtalar pronation angle while standing, * 2. a minimum score of +6 from the foot posture index (api) scale * 3. being between the ages of 18-45 * 4. not having received any treatment from the foot area in the last 6 months * 5. to have cognitive competence exclusion criteria: * 1. end of volunteering * 2. having a history of surgery of the lower extremity * 3. being an active athlete * 4. being pregnant or diagnosed with malignancy * 5. having a dysfunction such as severe neurological involvement, immobility, cooperation deficits that will limit physical activity * 6. lower extremity inequality greater than 1 centimeter (cm) * 7. having a different orthopedic disease that may affect lower extremity biomechanics * 8. receiving a different treatment for pes planus
corticosteroid dosage for crohn's disease flare

Conditions: Crohn's Disease; Inflammatory Bowel Disease

Summary: prospective randomized comparative effectiveness trial designed to compare fixed dosing and weight-based dosing of corticosteroids in patients with crohn's disease flares.

* determine if weight-based corticosteroid (1mg/kg daily) induces remission at a greater rate than fixed corticosteroid dosage. * determine if weight-based corticosteroid is associated with greater rate of adverse events than fixed corticosteroid dosage.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * established diagnosis of crohn's disease * diagnosis of crohn's flare * decision by treating gastroenterologist to start corticosteroid therapy exclusion criteria: * patients in whom corticosteroid therapy is contraindicated: immunocompromised (active cancer on chemotherapy or radiation treatment), severe liver disease (decompensated cirrhosis, active alcoholic hepatitis), end-stage renal disease on dialysis, aids or aids-defining illness; myocardial infarction within the past year; nyha class 4 heart failure * patients on systemic corticosteroid therapy currently or within the past 8 weeks * patients not on stable doses of immunomodulators or biologics for at least 8 weeks * infectious colitis (e.g., c. difficile, cmv, hsv) * systemic infections (bacteremia, fungal infections) * fulminant crohn's disease * patients who require imminent surgery * abscess * pregnancy * weight \<35 kg

Keywords: corticosteroid
comparison of carbon dioxide (co2) to air insufflation in colonoscopy in patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: patients with inflammatory bowel disease (ibd) frequently undergo endoscopic examination and may suffer from diagnostic procedures. independent from ibd patients, colonoscopy is usually performed using air insufflation, however recent data indicates a superior role of carbon dioxide (co2) as an insufflation gas during colonoscopy. using co2 leads to a lower degree of patient's discomfort. the role of co2 as an insufflation gas for colonoscopy in ibd patients remains undetermined, wherefore this study aims to address this issue.

patients with inflammatory bowel disease (ibd) suffer from a chronic inflammatory course of disease. to stage the course of disease endoscopic procedures including colonoscopy may be required and especially ibd patients with their inflamed gut may suffer from repetitive endoscopic examinations including colonoscopy. independent from ibd patients, colonoscopy is usually performed using air insufflation, however recent data indicates a superior role of carbon dioxide (co2) as an insufflation gas during colonoscopy. using co2 leads to a lower degree of patient's discomfort which has been mainly demonstrated in groups of patients undergoing cancer surveillance colonoscopies and who do not suffer from ibd. therefore the role of co2 as an insufflation gas for colonoscopy in ibd patients remains undetermined and this study aims to address this issue. for pain assessment a visual analogue scale will be used. as the primary outcome measure, the investigators will compare the differences in pain level 1h after colonoscopy (comparison of carbon dioxide to air insufflation). for the secondary outcome measure the investigators will compare the differences in pain level 3h, 6h and 24h after colonoscopy (comparison of carbon dioxide to air insufflation).

Eligibility criteria:
inclusion criteria: * patient with inflammatory bowel disease * indication for colonoscopy * age 18-80 years * signed consent form exclusion criteria: * consent form not signed * age \< 18 or above 80 yrs * pregnancy or breast-feeding

Keywords: inflammatory bowel disease crohn's disease ulcerative colitis carbon dioxide (co2) colonoscopy