Kornimate/medical-research-clean huggingface dataset:
probiotics in occupational shift workers

Conditions: Shift-Work Related Sleep Disturbance; Healthy

Summary: purpose: to evaluate the influence of probiotic supplementation on body composition and other markers of health in occupational shift-workers. participants: healthy, overweight females (ages 22-55 yrs) who are employed on a shift-working schedule. procedures (methods): in a randomized, placebo-controlled intervention, subjects will complete 3 different testing sessions (pre-screening, 1 baseline, 1 post-testing session) as well as a 6-week intervention period. prescreening will include written informed consent, a health history questionnaire, baseline anthropometric measures, assessment of resting heart rate, and exercise protocol familiarization. baseline testing will involve body composition, a fasted blood draw, mood surveys, and an exercise treadmill test. subjects will be randomized to a treatment group (multi-strain probiotic or placebo) for 6 weeks of supplementation that includes 2 electronic contacts, followed by post-testing that will occur in the same fashion as baseline testing.


Eligibility criteria:
inclusion criteria: * healthy, pre-menopausal women * currently employed on a shift-working (rotating, evening, or night) schedule and has maintained this schedule ≥ 6 months prior to enrollment * participant agrees to maintain usual activity lifestyle * participant has a body mass index of ≥25 kg/m2 * participant has provided written and dated informed consent to participate in the study * participant is willing and able to comply with the protocol * participant is apparently healthy and free from disease, as determined by a health history questionnaire * participant agrees to abstain from smoking, caffeine, tobacco, and alcohol before testing days * participant is not currently pregnant and does not desire to become pregnant in the next 8 weeks. exclusion criteria: * having a history of medical or surgical events that may significantly affect the study outcome, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders * participant is using, or has used a probiotic supplements within 8 weeks prior to enrollment * participant has lost or gained greater than 8 pounds within the previous 2 months * participant is in, or has participated in another clinical trial within 4 weeks prior to enrollment * participant had or currently has a self-identified eating disorder * participant is pregnant or plans on becoming pregnant * participant has a known allergy or sensitivity to any ingredient in the test product or placebo (determined from health history questionnaire)
clinical epidemiology cohort study for patient living with hiv

Conditions: HIV-1 Infection

Summary: this is a retrospective observational cohort study for the patient living with hiv aiming to understand more in disease progress, resistant mutation, comorbidity, and common coinfection.


Eligibility criteria:
inclusion criteria: * patient living with hiv receiving follow-up in kaohsiung vgh exclusion criteria: * not applicable
a biological sample collection protocol of women with and without breast cancer

Conditions: Breast Cancer

Summary: the purpose of this trial is to collect plasma, serum, whole blood and tissue samples from women with breast cancer and plasma, serum, whole blood from healthy women, which will be made available to researchers for biomarker analysis.

outline: this is a multi-center study. the treatment plan for each breast cancer subject will be determined at the discretion of the treating physician and subject. this protocol does not prescribe any particular standard of care treatment. there will be no treatment for the healthy volunteers.

Eligibility criteria:
inclusion criteria: for women with breast cancer * histologically or cytologically confirmed invasive malignancy or ductal carcinoma in situ of the breast. * preparing to begin a new regimen for breast cancer (adjuvant, locally recurrent, any line metastatic). * female. * age \> 18 years at the time of consent. * written informed consent and hipaa authorization for release of personal health information. for healthy volunteers * no known history of invasive malignancy or ductal carcinoma in situ. volunteers must not have prior history of malignancy in the past 5 years with the exception of basal cell and squamous cell carcinoma of the skin. other cancers with low potential for metastasis, such as in situ cancers (e.g., grade 1, ta tcc (low grade superficial bladder cancer), colonic polyp with focus of adenocarcinoma) can also be enrolled as healthy volunteers. * female * age \> 18 years at the time of consent. * written informed consent and hipaa authorization for release of personal health information. exclusion criteria: * females must not be pregnant.
improving bone health in adolescence through targeted behavioral intervention

Conditions: Bone Development; Dietary Adequacy

Summary: school based educational intervention to educate on bone health among hispanic, asian or non-hispanic white girls between 10-13 years with end points of knowledge gained, calcium intake and bone density in . the hypothesis was that the educational program would increase knowledge, improve dairy food and calcium consumption and enhance bone health in this population. a secondary hypothesis was that lactose maldigestion would be an impediment to improved dairy food consumption.

a targeted behavioral intervention to improve calcium intake and bone mass was conducted at middle schools in 6 states. the primary outcomes of bone mass and dietary calcium were assessed among asian, hispanic, or non-hispanic white girls between 10 -13 y. lactose maldigestion (lm) was determined by a breath hydrogen test (bht). perceived milk intolerance (pmi) and calcium intake were assessed by questionnaires and bone mineral content (bmc) was determined by dual energy x-ray absorptiometry (dxa). data from 473 girls were used in a multiple linear regression to examine the impact of the intervention while accounting for pmi and lm and adjusting for covariates.

Eligibility criteria:
inclusion criteria: middle schools within one-hour driving time of one of the designated dxa measurement sites were eligible to participate in act if their student population had a higher proportion of asian or hispanic students than the respective state's average. - girls recruited for evaluation measures were limited to those being at least 75% asian, hispanic or non-hispanic white based on the race/ethnicity of their biological parents. exclusion criteria: -

Keywords: adolescents bone mass calcium perceived milk intolerance lactose maldigestion
study to compare between combimed metformin-letrozole and ovarian drilling in pcos with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome

Conditions: Focus of Study

Summary: the study compare the hormonal-metabolic and reproductive outcome between combined metformin-letrozole and ovarian drilling in clomiphene resistant women with polycystic syndrome


Eligibility criteria:
inclusion criteria: * polycystic ovary syndrome * infertility * clomiphene citrate resistance exclusion criteria: * women with other causes of infertility as male factor or tubal factor, those with endocrine disorders as thyroid dysfunction and hyperprolactinemia women who received hormonal treatment or ovulation induction drugs 3 months prior to the study * pregnancy during follow up

Keywords: metformin letrozole ovarian drilling clomiphene resistance polycystic ovary.
assist tool and surgical randomized controlled trial applicability

Conditions: Digestive Cancer

Summary: background: the assist tool is a graphical tool to represent and evaluate the applicability of a surgery trial to improve the translation of research to practice. objective: to evaluate the impact of the assist tool on the interpretation of the applicability of randomized controlled trials (rcts) in the field of digestive cancer surgery. design: this study is a randomized controlled trial with two parallel arms. participants: surgeons who contribute to the assessment of manuscripts as experts (peer-reviewer) for international scientific journals of surgery (annals of surgery, archives of surgery, gastrointestinal surgery world journal of international journal of surgical oncology). intervention: surgeons will be randomized into 2 groups. a group that will evaluate a case vignette (synopsis) of a randomized trial in surgery, and the other group that will evaluate the same case vignette with the representation of the external validity of the trial with assist tool. outcome measures: participants will indicate on a numeric scale range from 1 to 10 if they feel able to judge the applicability of the trial for 1) patients, 2) centers, 3) surgeons and 4) intervention. sample size: 28 case vignettes with randomized trials and their assist tool have been developed and evaluated. the inclusion of 130 participants (65 per arm) is required.

the study will be conducted in 2 steps: in a first step, investigators will develop cases vignettes of published rcts evaluating surgical interventions in the field of digestive cancer with its representations of external validity according to assist. in a second step, investigators will invite a panel of peer reviewers to appraise the external validity (applicability) of selected rcts without and with the graphical tool (assist), on a security web site.

Eligibility criteria:
inclusion criteria: * surgeons * who contribute to the assessment of manuscripts as experts (peer-reviewer) for international scientific journals of surgery (annals of surgery, archives of surgery, gastrointestinal surgery world journal of international journal of surgical oncology) exclusion criteria: * no one

Keywords: randomized controlled trial applicability assist tool surgery digestive cancer
propranolol administration and prevention of child ptsd in child trauma victims

Conditions: Posttraumatic Stress Disorders

Summary: twenty-nine pediatric injury patients (ages 10-18) at risk for ptsd were randomly assigned to receive either propranolol or placebo in a double-blind placebo controlled design. medication was initiated within 12 hours of hospital admission. at 6-weeks, child ptsd symptoms and heart rate (hr) during trauma recall were assessed. we hypothesized that participants who received propranolol would report fewer ptsd symptoms and have lower heart rates than those who received placebo.


Eligibility criteria:
inclusion criteria: * participants consisted of 15 male and 14 female accidental injury patients aged 10-18 recruited from the emergency department of akron children's hospital. - eligibility criteria included a glasgow coma scale (gcs) score of 14 or greater (to permit informed consent) and an "at-risk" child score on the stepp (winston, kassam-adams, garcia-espana, ittenbach, \& cnaan, 2003), a screen for risk of ptsd. exclusion criteria: * medication-specific exclusion criteria included hypersensitivity to beta-blockers * bradycardia * cardiogenic or hypovolemic shock * diabetes * preexisting heart condition; or * treatment for asthma within the year prior to study entry (per lacy, armstrong, goldman, \& lance, 2002). * children were also excluded if they received epinephrine during emergency care or if they sustained any injuries precluding initiation of the propranolol regimen within 12 hours post-trauma.

Keywords: posttraumatic stress disorder propranolol inderol child trauma posttraumatic stress disorders (ptsd)
mindfulness training for smoking cessation

Conditions: Cigarette Smoking; Tobacco Smoking; Nicotine Dependence; Smoking Cessation

Summary: the purpose of this study is to assess the effects of mindfulness training (mt) compared to standard smoking cessation therapy (sct) on smoking cessation and stress provocation in individuals trying to quit smoking.


Eligibility criteria:
inclusion criteria: 1. between the ages of 18 and 60 2. smoking 10 or more cigarettes per day 3. fewer than 3 months of smoking abstinence in the past year 4. motivated to stop smoking exclusion criteria: 1. current use of psychoactive medications that have not been at a stable dose for the past six months, are used as mood stabilizers, or are used as smoking cessation treatments. individuals who are on psychoactive medications that are stable, not mood stabilizers, and not used for smoking cessations are excluded from fmri sessions but not smoking cessation treatment. 2. use of another investigational drug within 30 days 3. any serious or unstable disease within 6 months 4. meets criteria for substance dependence within the past year 5. left handed (will be excluded from fmri only)

Keywords: mindfulness smoking stress
treatment of spastic equinovarus foot after stroke

Conditions: Spastic Equinovarus

Summary: this study evaluates treatment for spastic foot after stroke using ankle foot orthosis with or without selective injection of bta (botox).

this prospective, multicentric open trial evaluates the efficacy of a combined treatment for spastic foot after stroke using ankle foot orthosis with or without selective injection of bta (botox) into the tibialis anterior and/or posterior and/or the long toe flexor, and/or medial and lateral gastrocnemius, and/or soleus muscles \[300 bta u per injection (botox - allergan), diluted with saline to a concentration of 5u/0,1 ml, with electromyography guided injection\]. the patients are followed for one year after treatment.

Eligibility criteria:
inclusion criteria: * stroke patient with equinovarus foot due to severe lower limb extensor spasticity with impaired foot contact during walking * ability to walk for at least 10 meters with or without aid * stroke interval \< 12 months * age \> 18 years old * weight \> 30 kg and \< 100 kg * written informed consent exclusion criteria: * stroke interval \> 12 months * age \< 18 years old * pregnancy * neuromuscular disease * previous treatment with bta * fixed contractures impairing mobility * mini-mental status examination \< 25 * aminosides treatment.

Keywords: spastic equinovarus botox ankle foot orthosis
effects and mechanism of pretreatment with dexmedetomidine to etomidate induce myoclonus

Conditions: Myoclonus

Summary: by observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring narcotrend index, study the possible mechanism of influencing etomidate induced myoclonus with dexmedetomidine pretreatment during general anesthesia induction period.


Eligibility criteria:
inclusion criteria: * sign the informed consent * american society of anesthesiologists (asa)classification:class i\~ii;undergoing elective surgery patients * aged between 18 and 55, 49-67 kg weight * body mass index（bmi）： 20-30 kg/m2 * did not use any analgesic or sedatives drugs within 24 h pre-operation exclusion criteria: * recently patients undergoing sedative drugs and antidepressant treatment * serious vision, hearing impairment or other reasons can not communicate * serious neurological disease, pregnancy, diseases of the cardiovascular system； * bmi is less than the standard 80% or higher than the standard 120%

Keywords: myoclonus etomidate dexmedetomidine
use of fish skin graft (fsg) to improve wound healing and expedite discharge at a county safety-net hospital

Conditions: Surgical Wound

Summary: the purpose of this study is to estimate the effect of fsg (kerecis) on hospital length of stay among adult patients with surgical wounds of at least 40cm2 requiring surgical debridement


Eligibility criteria:
inclusion criteria: * has wound greater than or equal to 40cm2 requiring surgical debridement * agreeable to follow up period of up to 1 year exclusion criteria: * patients with wounds that do not require surgical debridement. * patients with a known allergy or other sensitivity to fish material * patients who are deemed unlikely to follow up (e.g., patients who live out of state). * patients in police custody/incarcerated. * patients unable to communicate in either spanish or english.

Keywords: fish skin graft (fsg) kerecis
microarchitecture of vitreoretinal contact

Conditions: Vitreoretinal Detachment; Vitreo-Retinal Adhesion

Summary: investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.

purpose: to study the features of the macular ilm, to study the features of the preretinal structures of the vitreous body of the central retinal region, morphofunctional features of preretinal hyalocytes, and the mechanism of vitreoretinal adhesion. study protocol: examination of donor human eyes obtained from an eye bank after sampling material for corneal transplantation. research method: scanning electron microscopy (sem) of the central retina (macular and paramacular zone): ilm, preretinal vitreous. scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous. expected results: determination of ilm thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.

Eligibility criteria:
inclusion criteria: * eyes from donors without concomitant multiple organ pathology and ophthalmic pathology exclusion criteria: * eye injury, age over 45 years, concomitant multiple organ pathology, previous eye diseases

Keywords: internal limiting membrane human vitreous vitreomacular adhesion vitreoretinal contact vitreoretinal interface hyalocytes collagen
cervicogenic headache, cognitive dysfunction

Conditions: Cervicogenic Headache

Summary: the goal of this study was to determine the frequency of cognitive dysfunction in patients with cervicogenic headache. participants will be asked questions to determine their cognitive status at once.

a set of survey-type questions will be asked to the participants. pain and fatigue levels of the patients were measured by visual pain scale (vas), mood states by beck depression scale (bdi) and pain catastrophizing scale (pain catastrophizing scale), quality of life by short form-36 (sf-36), and cognitive status by standard mini. mental test (smmt) and montreal cognitive assessment scale (moca).

Eligibility criteria:
inclusion criteria: clinical diagnosis of cervicogenic headache be over 18 exclusion criteria: those under the age of 18 those with neurological deficits those with rheumatic diseases such as fibromyalgia, polymyalgia rheumatica, ankylosing spondylitis, rheumatoid arthritis surgery in the cervical region in the past 6 months those with widespread pain, significant pain in another anatomical location (eg, gonarthrosis) those who use drugs or substances (alcohol, drugs, etc.) that may cause cognitive impairment those with known neurological diseases such as cerebrovascular disease, ms, parkinson's, dementia those with major psychiatric illness those with communication problems those who have started psychiatric medical treatment in the last three months those with significant hearing or vision problems those with a history of uncontrollable systemic disease (cardiovascular, pulmonary, hepatic, renal, hematological, endocrine..)
hepatitis c education for pregnant women with opiate dependence - phase 2

Conditions: Hepatitis C

Summary: the goal of this study is to assess patients' attitudes and knowledge of hepatitis c, analyze the variables that may influence patients' knowledge, and educate patients on hepatitis c.

the study will compare the effectiveness of providing hcv education by providing a pamphlet and expert education compared to providing a pamphlet only. the information gained in completing this study will help the medical community improve patient education on the disease and specifically understand how the medical community can best serve pregnant patients with opiate dependence burdened by hepatitis c.

Eligibility criteria:
inclusion criteria: * study population includes faculty medical center obstetrics and postpartum patients enrolled in the hope program who are 18 years old or older. * the study will include patients with and without a hepatitis c diagnosis. * patients will be recruited at their routine office visits and/or during any admissions to the hospital. exclusion criteria: * patients who do not speak and understand english.
radiation therapy with androgen suppression in treating patients with prostate cancer

Conditions: Prostate Cancer

Summary: rationale: imaging procedures such as mri may improve the ability to determine the response of prostate tumors to therapy. purpose: phase ii trial to study mri results in patients with prostate cancer that has been treated with radiation therapy plus androgen suppression therapy.

objectives: i. establish whether changes between baseline and 2-month post androgen suppression endorectal coil mri results predict for biochemical control following radiotherapy with androgen suppression in patients with adenocarcinoma of the prostate. outline: patients undergo a baseline endorectal coil mri, followed by total androgen suppression (tas) with either leuprolide im or subcutaneous goserelin once a month plus oral flutamide 3 times a day for 2 months. patients then receive a second endorectal coil mri, followed by 2 months of external-beam radiotherapy plus tas. patients may receive an additional 2 months of tas at the discretion of the treating physician. patients are followed every 6 months for 3 years, then yearly thereafter. projected accrual: approximately 180 patients (approximately 60 per year) will be accrued for this study over a 34 months.

Eligibility criteria:
disease characteristics: histologically confirmed adenocarcinoma of the prostate ajcc stage t1b-t4b, n0 or nx, m0 transrectal, transperineal, or transurethral biopsy required patient characteristics: age: 30 and over performance status: calgb 0-2 hematopoietic: not specified hepatic: not specified renal: not specified other: the following may increase the risk of protocol treatment: serious intercurrent medical illness that might compromise patient safety active acute infection requiring antibiotics suppression therapy for chronic urinary tract infection allowed uncontrolled or severe cardiovascular disease psychiatric conditions that prevent compliance or informed consent prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior chemotherapy for carcinoma of the prostate endocrine therapy: no prior androgen deprivation therapy (medical or surgical) radiotherapy: no prior radiation therapy for carcinoma of the prostate surgery: no prior surgical androgen deprivation therapy

Keywords: adenocarcinoma of the prostate stage i prostate cancer stage ii prostate cancer stage iii prostate cancer stage iv prostate cancer