Kornimate/medical-research-clean huggingface dataset:
comparison of open and closed chain exercises in athletes with patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: patellofemoral pain syndrome (pfps) is a common source of knee pain in the physically active population, predominantly in women. the incidence rate of pfps among athletes is 25 percent, which is higher than that of general population. pfps is caused by repetitive stress and aggravated in athletes by cycling and running. these symptoms are caused by structural or biomechanical changes of the joint, which becomes exacerbated by activities such as going up and down stairs, sit for a prolonged period, squatting or kneeling, resulting in increased compressive forces in the joint patellofemoral. it is characterized by defused pain in front of knee. other signs also present are the patellar crepitus, swelling, and joint blockage despite being deemed a multifactorial condition with no single cure, pfps is commonly attributed to muscular dysfunction, for which conservative rehabilitation is the treatment of choice. historically, pfps has been linked to impairments of the quadriceps muscle.

this study will be a randomized clinical trial will be conducted in pakistan sports board lahore, model town sports club lahore and sheikh zaid hospital, lahore. sample size will be taken to evaluate the effects of open chain exercise and closed chain exercise among athletes with an age group of 18 - 40 years. non probability convenient sampling technique would be used. players having an experience of at least 8 months would be a part of study experiencing recurrent knee pain. participants will be randomly assigned to 2 groups. group a will include participants who will receive open kinetic chain exercises 3sets of 10 repetitions for each exercise along with the general training. group b will include the participants who will receive closed kinetic chain exercises 3sets of 10 repetitions for each exercise along with general training.3sessions per week will be given for 6weeks.the subjects will be assessed for pain, function and balance at baseline and after 6weeks of treatment. after collecting data from defined settingit will be entered and analyzed using statistical package for social sciences (spss) for windows software, version 25.

Eligibility criteria:
inclusion criteria: * adult athletes with age 18 to 30 years * anterior knee pain * an insidious onset of symptoms not related to trauma. * pain with compression of patella. * pain on palpation of patellar facets. * experienced players (who are in practice from last 8 months or a year). exclusion criteria: * symptoms present less than 1 month. * intra-articular knee pathologies like o.a, r.a etc * history of knee surgery within last year. * history of traumatic injuries like patellar dislocations or subluxation * any other lower extremity injuries.

Keywords: pfps, ocke, ccke
lesser toe pip joint arthrodesis versus resection arthroplasty

Conditions: Claw Toe; Lesser Toe Deformity

Summary: background: the aim of this study was to compare operative outcomes after lesser toe deformity correction with either proximal interphalangeal (pip) joint arthrodesis or pip joint resection arthroplasty. methods: a prospective randomized controlled trial was performed on 37 patients (48 toes) who underwent one of these two procedures. the numeric rating scale (nrs) for pain, american orthopaedic foot and ankle society (aofas) score, osseous consolidation, and clinical outcome were evaluated preoperatively and at 6 weeks and 6 months postoperatively.


Eligibility criteria:
inclusion criteria: * patients with one or more claw toes with rigid pip joint flexion and extension deformity of the mtp joint scheduled for surgical intervention in the investigator's department exclusion criteria: * known osteoporosis or other bone metabolism disorders * prior surgery on the toe scheduled for the intervention * immunodeficiency or immunosuppressive drug intake * pregnancy * non-palpable pulses of the posterior tibial artery or the dorsalis pedis artery * anticoagulation therapy with the exception of acetylsalicylic acid * a lack of sufficient physical resilience to allow free self-mobilization and walking.

Keywords: lesser toe deformity claw toe pip joint arthrodesis resection arthroplasty
effects of transcranial direct current stimulation in refractory chronic migraine and medication-overuse headache

Conditions: Chronic Migraine; Medication Overuse Headache

Summary: the purpose of the study is to evaluate the efficacy of the transcranial direct current stimulation of the primary motor cortex (m1) in patients affected by refractory chronic migraine (coded as 1.5.1 in the international headache classification 2nd edition, 2004) and medication-overuse headache (coded as 8.1) with migraine as primary headache.


Eligibility criteria:
inclusion criteria: * chronic migraine or medication overuse headache according to the diagnostic criteria set out in the 2nd edition of the international classification of headache disorders refractory to treatment according to the refractory headache special interest section of the american headache society (schulman et al., 2008) exclusion criteria: * other primary or secondary headaches. * any serious systemic or neurological disease or psychiatric disorder. * pregnancy or breastfeeding * previous or current use of other or similar devices for pain control * heart conduction and rhythm disorders * cranial surgery * other pain conditions, accordingly with current guidelines

Keywords: chronic migraine medication overuse headache refractory transcranial direct current stimulation
early repolarization syndrome: define the risk, stratify the coverage and understand the causes - clinical and genetic study

Conditions: Early Repolarization Syndrome

Summary: the research project aims to try to answer the many questions raised by the identification of new early repolarization syndrome. the questions are varied with both taking optimal clinical management of patients, the frequency and significance of this anomaly in the population on the electrophysiological and molecular basis responsible for this electrocardiographic abnormality. to try to answer these many questions, the approach will be twofold: clinical and genetic. * establishment of a clinical database containing information of patients who have been identified as carriers of the anomaly based on the initial clinical presentation in order to determine their prognoses. * physiological approach will be based on a molecular approach to identify genetic abnormalities may be involved in this syndrome. * 200 asymptomatic patients and an unlimited number of patients who presented syncope or aborted sudden death will be included. a blood sample (15 ml) will be performed at inclusion.


Eligibility criteria:
inclusion criteria: * presence of early repolarization aspect, determined by the j point elevation of at least 0.1 mv above the isoelectric line, with or without extra-st segment elevation in at least two leads and / or lateral. * parameters ecg d2 level of the bypass measurable for the presence of long qt syndrome. * late potentials ventricular analyzable. * for patients with ventricular fibrillation, negative search for other causes of ventricular fibrillation. * for patients with syncope, clinical assessment should included at a minimum, performing a cardiac ultrasound and a stress test. exclusion criteria: * impossibility to receive clear information (patient's intellectual default). * refusal to sign the informed consent for participation. * under protective measure of justice.
resiliency training for adolescents with craniofacial conditions and their caregivers

Conditions: Craniofacial Abnormalities

Summary: this is a prospective study that will examine psychosocial improvements among cf adolescents and caregivers going through the stress management and resiliency training - relaxation response resiliency program (smart-3rp).


Eligibility criteria:
inclusion criteria for adolescent patients: 1. adolescents aged 14 to 22 2. english fluency and literacy 3. diagnosis of a craniofacial condition by self report inclusion criteria for parents or other caregivers: 1. must be 18 years of age and older 2. english fluency and literacy 3. parent or caregiver of a child or young adult with a craniofacial condition exclusion criteria: 1. unable to benefit from the program due to cognitive, psychiatric or other reasons based on the opinion of the group leader 2. unable or unwilling to sign the informed consent documents
frailty and spinal anesthesia-induced hypotension in elderly

Conditions: Frailty; Spinal Anesthesia

Summary: 60 patients aged 65 and older with asa i-iii physical status undergoing elective surgery under spinal anesthesia will be included in the study. patients with cardiac arrhythmia, severe heart failure, cerebrovascular disease, or contraindications to neuraxial anesthesia will be excluded. frailty assessments will be performed using the clinical frailty scale (cfs) version 2.0 by anesthesiologists in preoperative clinics or wards. participants will be categorized into frail (cfs level ≥4, group i) and non-frail (cfs level ≤3, group ii) groups. prior to spinal anesthesia, 8 ml/kg of crystalloids will be administered. baseline preoperative mean arterial blood pressure (mabp) and heart rate (hr) will be recorded as the average of three measurements in the supine position. during the study, mabp and hr will be monitored every 2 minutes for the first 20 minutes post-spinal anesthesia, then every 5 minutes until surgery ends. hypotension (mabp \<80% of baseline) will be treated with 5 mg intravenous ephedrine, while bradycardia (hr \<50 beats/min) will be treated with 0.5 mg intravenous atropine.


Eligibility criteria:
inclusion criteria: * 65 and older * asa i-iii physical status * undergoing elective surgery under spinal anesthesia exclusion criteria: * patients with cardiac arrhythmia * patients with severe heart failure * patients with cerebrovascular disease * contraindications to neuraxial anesthesia
impact of exercise training on cardiac function in man

Conditions: Cardiovascular Disease

Summary: the purpose of this study is to monitor the impact of exercise training on cardiac functions and lipoprotein lipids.

exercise can increase the mass of left ventricle, which is also called athletic heart. athletic heart is most frequently encountered as a pathological manifestation of cardiovascular disease, and the early determinants of athelitic remodeling in the general population are largely unknown. we will recruit 45 men aged 18-25 years who will run 5000 meters 2/day for 3 months. caridac function is examined by ecg and echocardiogram, blood pressure, lipoprotein, heart rate, body weight, cardiac troponin will be examined prior to exercise program and 3 months after exercise.

Eligibility criteria:
inclusion criteria: * men * age 18-25 years * body mass index (bmi) 18-25 kg/m2 * no regular exercise * no tobacco use * no current use of prescribed medications * no self-report of acute of chronic diseases exclusion criteria: * conditions that do not meet the inclusion criteria listed.

Keywords: exercise lipid left ventricular heart function
adaptation of mattresses made with different materials to personal anthropometry values and body postures

Conditions: Pressure Ulcer; Sleep Disorder; Spine Degeneration; Body Structure, Altered From Its Original Anatomical Structure

Summary: sleep disorders affect 40% of the adult population each year and are often associated with morbidity and mortality (kripke et al., 2002; f.-z. low et al., 2017). sleep quality plays a vital role in the overall quality of our lives. therefore, a good sleep helps to create a quality life rhythm. a quality sleep reduces fatigue and increases physical regeneration (khaleghipour et al., 2015). poor sleep quality is due to various environmental factors such as temperature, light, noise and bed quality (lei et al., 2009). it has been reported that 7% of sleep problems are caused by inappropriate mattresses that affect the load on the spine during sleep (f. z. low et al., 2017). body contact pressure is a measure of the distribution of body weight across the body surface in contact with the mattress. a well-designed mattress usually has the ability to minimize high pressure points applied to the body. however, if the bed is not suitable for the person, pressure sores may develop in the body parts where pressure is intense (cullum et al., 2004). the areas most affected by high pressure are usually the hips, shoulders and back, which can affect sleep quality and result in drowsiness or body stiffness throughout the day (jacobson et al., 2002). a recent study by bae and ko compared the bed positions of hospital beds and found that a head-to-foot angle of 30° is the best position to reduce the likelihood of decubitus ulcers occurring in patients in high-pressure risk areas (bae \& ko, 2013). in the light of previous studies, it has been observed that there is no study comparing many bed types designed using different materials for individual-specific postures. biomechanical comparison of these bedding materials in individuals with different posture types and sleeping in different sleeping positions will allow us to provide new insights into their pressure distribution abilities. the aim of this study is to measure the effect of mattresses made of different mattress materials on body contact pressure profiles in individuals with different postures in various sleeping positions. it will be evaluated using maximum body pressure and pressure distribution as outcome measures.


Eligibility criteria:
inclusion criteria: * volunteer to participate in research exclusion criteria: * having a history of back, shoulder or neck pain in the last 6 weeks * having a surgical operation in the last 8 weeks
biomechanical properties and their association with balance and functional mobility in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study aimed to investigate the differences in the biomechanical properties of the dorsal trunk and lower extremity muscles of children with unilateral spastic cerebral palsy compared with their typically developing peers, and the effect of these biomechanical properties on balance and functional mobility performance.


Eligibility criteria:
inclusion criteria for unilateral spastic cerebral palsy were: * aged between 4 and 12 years, * spasticity level mas≤2, * mental level sufficient to understand commands given, * and ambulation without the use of an orthosis or other device. in addition, children had to be gmfcs level i or ii. exclusion criteria were: * a history of spinal surgery or spinal orthosis use, * uncorrected vision or hearing problems, * severe epileptic seizures, * lower extremity contractures, * botulinum toxin a injection in the previous six months, * lower extremity surgery in less than one year, * use of pharmacological agents that affect muscle tone, * and poor cooperation. inclusion criteria for controls were: * aged between 4 and 12 years, * no neurological or orthopaedic diagnosis, * no known systemic problems, * normal vision and hearing, * and a mental level sufficient to understand the commands given.

Keywords: postural balance muscle properties mobility paralysis children
the effect of physiotherapy on lower extremity function and gait in children with isolated gastrocnemius muscle tightness

Conditions: Lower Extremity Biomechanics; Gastrocnemius Tightness; Pes Planovalgus

Summary: since the gastrocnemius muscle crosses both joints, the joint kinematics of the ankle are affected by knee flexion. according to the kendall \& mccreary assessment of normal joint motion angles, the generally accepted normal range of motion for ankle dorsiflexion is 20° when the knee joint is in extension and can approach 30° when the knee joint is flexed due to relaxation of the gastrocnemius. in the mid-stance phase of gait, it is observed that the ankle joint allows 8-10° dorsi flexion movement. in this study, a minimum 13° increase in dorsiflexion with knee flexion compared to dorsiflexion with knee extension will be considered as isolated gastrocnemius muscle tightness. isolated gastrocnemius muscle tightness has been associated with many biomechanical changes such as pes planus, talar equinus, hindfoot pronation and symptoms such as plantar fasciitis, leg pain, metatarsalgia, achilles tendinopathy by compensatory effects on the lower extremity and foot during gait. the association of increased hindfoot pronation with isolated gastrocnemius tightness has been shown in many studies. regardless of the etiology of pronation of the hindfoot, there will be adaptive isolated gastrocnemius tightness with talar plantar flexion. isolated gastrocnemius tightness, which causes plantar flexion in the ankle joint and pronation in the subtalar joint, also prevents the distribution of the load to the base of the foot within normal limits during weight bearing. however, no study investigating the effect of physiotherapy program on function and gait has been encountered. the aim of this study was to investigate the effect of a physiotherapy program on lower extremity function and gait in children with isolated gastrocnemius muscle tightness.


Eligibility criteria:
inclusion criteria: * presence of bilateral pes planovalgus due to the isolated gastrocneius tightness * being the ages between 4-10 years old * having body mass index between within normal limits exclusion criteria: * presence of high femoral anteversion (craig test \> 30 degrees) and/or internal tibial torsion and/or metatursus adductus * having of leg length discrepancy * accompanying any neurological, rheumatologic, musculoskeletal, metabolic and connective tissue disease * presence of pain associated with the vertebral column and lower extremities * presence of any lower extremity and/or vertebral column deformity or history of surgery * cognitive, mental, serious psychiatric illness * participation in any exercise program and/or sportive activity in the last six months

Keywords: isolated gastrocnemius muscle tightness physiotherapy lower extremity function gait
feasibility of imrt modulation to account for scattered radiation from dental fillings in head and neck cancer

Conditions: Head and Neck Cancer

Summary: the main objective of this study is to determine the feasibility of optimizing the imrt treatment plan based on dosimeter measurements of mucosal radiation dose adjacent to the dental fillings to reduce such dose to \< 35 gy without compromising tumor coverage and/or increasing the dose to the remaining oral cavity or nearby parotid glands.

using radiation dosimeter, we will perform measurement of the doses received by the mucosa adjacent to the dental fillings in patients receiving imrt for head and neck cancer. if the mucosa dose is estimated to be greater than 35 gy for the entire radiation course, we will generate and implement a "filling" optimized imrt plan, provided that this new plan does not compromise tumor coverage or increase dose to the rest of the oral mucosa or parotid glands. dosimeter will be used to measure the mucosal dose delivered by this new imrt plan. patient's mucositis grade, narcotic use and self-reported mouth and throat soreness scores will be recorded and correlated to mucosal dose. we hypothesize that modulation of an imrt plan to reduce the dose delivered to adjacent normal mucosa surrounding the dental filling can decrease the severity and duration of radiation-related oral mucositis. here we propose to use thermoluminescent dosimeter (tld) to measure the mucosal dose adjacent to the dental fillings in a standard, "non-filling" optimized imrt plan that is normally delivered in the clinic.

Eligibility criteria:
inclusion criteria: * patients with hnc undergoing radiation therapy +/- chemotherapy at stanford university * at least 18 years old * metallic filling present * planned radiation dose to the tumor \> 60 gy at 1.8 to 2.2 gy/fx * able to understand and sign a written informed consent document. exclusion criteria: * pregnant * nursing
a non-inferiority, multicenter and randomized, single-dose study about a treatment to hypolactasia (lailai)

Conditions: Hypolactasia

Summary: the study primary objective is to compare the clinical efficacy of two formulations in the supportive treatment of lactose intolerance.


Eligibility criteria:
inclusion criteria: 1. the patient should be a male or female, aged between 18 and 60 years old; 2. have a medical history consistent with lactose intolerance, confirmed by the test of hydrogen in the expired air; 3. the female patients should agree to use birth control methods during the study participation; 4. to be able to meet the study instructions and all the visits required; 5. to give a free consent to participate in the study and sign the informed consent form (icf). exclusion criteria: 1. smoking; 2. secondary hypolactasia; 3. gastrointestinal inflammatories diseases - present diverticular disease, diabetic gastropathy or neoplasias; 4. colonoscopy or colon cleaning procedure 4 weeks before the start of study 5. latrogenic: unnoticed intake of laxatives in over-the-counter drugs or alternative medicine, intake of cereal bran or probiotics; 6. diagnosis of hiv, immunodepression of any origin, or cancer under treatment. 7. diagnosis of other comorbidity that, at the investigator's discretion, may compromise the study participation (e.g., systemic infection during the study or use of antibiotics in the last 4 weeks, diabetes mellitus, uncontrolled hypertension or renal failure), 8. hypersensitivity or previous laboratory or clinical adverse event related to the use of lactase or any of the components of the formulations used in the study; 9. incapacity to understand and complete the study questionnaires, including the questions that require the use of the visual analogue scale and icf; 10. pregnancy or lactation; 11. use of alcohol, exceeding 3 doses daily; 12. participation in another clinical study on the last 12 months; 13. patient having some chronic pulmonary disease that, in the investigator's opinion, may harm or interfere with the expired hydrogen test (e.g., cystic fibrosis).
virtual reality in orthopedic rehabilitation

Conditions: Arthropathy; Anxiety; Stress

Summary: the study's objective is to evaluate the efficacy of implemented virtual reality therapy for patients who have undergone lower limb arthroplasty and are in inpatient rehabilitation. the study aim to examine its influence on reducing anxiety levels, mitigating depressive symptoms, enhancing motivation for elderly patients to participate in physiotherapy, and improving their overall functional state and fall risk.

the study will include elderly patients (60+) who present sequentially at the general systemic rehabilitation department of st. hedwig of silesia hospital in trzebnica, within 3 months of having undergone hip or knee joint arthroplasty surgery. patients will be randomly assigned to one of two groups: a. virtual reality group: 8 therapy sessions, two sessions per week; b. control group, undergoing conventional rehabilitation. participation in the study is entirely voluntary, and written consent is required.

Eligibility criteria:
inclusion criteria: * individuals who have recently undergone hip or knee joint arthroplasty surgeries aged 60 years and above. exclusion criteria: * cognitive impairments that prevent independent completion of research questionnaires * reported consciousness disorders * bipolar affective disorder and other serious mental disorders in the patient's medical history * use of psychoactive drugs * ongoing psychiatric treatment or individual psychological therapy * contraindications to virtual reality such as epilepsy, vertigo, serious vision disorders * functional status preventing independent movement (orthopedic aids are allowed, e.g., crutches, walker) * refusal to participate in the study at any stage

Keywords: arthroplasty stress fall risk depression anxiety self-efficacy