pilot clinical evaluation of approved contact lenses

Conditions: Vision Disorders

Summary: this is a pilot evaluation to assess the feasibility of using novel imaging process to characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; and conjunctival microvasculature including fractal analysis of microvascular perfusion maps and blood flow velocity.

this is a pilot evaluation to assess the feasibility of using ultra-high resolution optical coherence tomography (oct) to image and characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; and conjunctival microvasculature including fractal analysis of microvascular perfusion maps and blood flow velocity.

Eligibility criteria:
inclusion criteria: * the subject must read, understand, and sign the statement of informed consent and receive a fully executed copy of the form. * the subject must appear able and willing to adhere to the instructions set forth in this clinical protocol. * the subject must be at least 18 and not more than 70 years of age. * the subject's refractive cylinder must be \< 1.00 diopters (d) in each eye. * the subject must have best corrected visual acuity of 20/25 or better in each eye. * the subject must be either a neophyte or a habitual and adapted wearer of soft contact lenses in both eyes. * the subject must have normal eyes (i.e., no ocular medications or infections of any type). * the subject must demonstrate adequate mobility and 20/30 vision oculus dexter (od) and oculus sinister (os) with the study contact lenses. exclusion criteria: * currently pregnant or lactating (subjects who become pregnant during the study will be discontinued). * any ocular or systemic allergies or diseases that may interfere with contact lens wear. * any systemic disease, autoimmune disease, or use of medication that may interfere with contact lens wear. * entropion, ectropion, extrusions, chalazia, recurrent styes, glaucoma, history of recurrent corneal erosions, aphakia. * any previous, or planned, ocular or interocular surgery (e.g., radial keratotomy, photorefractive keratectomy (prk), laser-assisted in-situ keratomileusis (lasik), etc.). * any grade 3 or greater slit lamp findings (e.g., edema, corneal neovascularization, corneal staining, tarsal abnormalities, conjunctival injection) on the fda classification scale, any previous history or signs of a contact lens-related corneal inflammatory event (e.g., past peripheral ulcer or round peripheral scar), or any other ocular abnormality that may contraindicate contact lens wear. * any ocular infection. * any corneal distortion resulting from previous hard or rigid gas permeable contact lens wear. * monovision or multi-focal contact lens correction. * participation in any contact lens or lens care product clinical trial within 14 days prior to study enrollment. * history of binocular vision abnormality or strabismus. * any infectious disease (e.g., hepatitis, tuberculosis) or a contagious immunosuppressive disease (e.g., hiv, by self report). * suspicion of or recent history of alcohol or substance abuse. * history of serious mental illness. * history of seizures. * employee of investigational clinic (e.g., investigator, coordinator, technician)