Kornimate/medical-research-clean huggingface dataset:
effects of vestibular stimulation on motor function and balance in children with hypotonic cerebral palsy

Conditions: Hypotonic Cerebral Palsy

Summary: my study base on 2groups with total sample size 68 patients .group a conventional physiotherapy group in which the duration of session is 30 mints with 5 mints rest .include soft tissue elogation of tight muscles,lowerlimb resistance exercise,movement transitions balance board standing walking and stair climbing.for group b (conventional physiotherapy and vestibular stimulation exercises)30 mints with 10 mints rest.same physiotherpy exercise re given with vestibular stimulation exercises include swinging in standing in all diection,trampoline jump,rocking movement in rocking chair gaze stabilization exercises and visual pursuit exercises

my study base on 2groups with total sample size 68 patients .group a conventional physiotherapy group in which the duration of session is 30 mints with 5 mints rest .include soft tissue elogation of tight muscles,lowerlimb resistance exercise,movement transitions balance board standing walking and stair climbing.for group b (conventional physiotherapy and vestibular stimulation exercises)30 mints with 10 mints rest.same physiotherpy exercise re given with vestibular stimulation exercises include swinging in standing in all diection,trampoline jump,rocking movement in rocking chair gaze stabilization exercises and visual pursuit exercises under supervisio. and use 2 scales,pediatric balance scale and gross motor scale re used for taking data .

Eligibility criteria:
inclusion criteria: * age range from 5-10 years. * both male/female * have good head control * hypotonic cerebral palsy * able to maintained ring sitting position exclusion criteria: * children will not respond to visual and auditory stimuli due to blindness or deafness or sever mental retardation * children with un controlled convulsion or vp shunt * children with severe medical problems children with orthopedic condition

Keywords: vestibular stimulation motor function balance
the secretion of incretin hormones in patients with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is an endocrine disease in reproductive women. it is characterized by anovulation and hyperandrogenism. most patients with pcos have metabolic abnormalities such as dyslipidemia, insulin resistance and glucose abnormalities. almost 60-80﹪pcos patients are obesity which exacerbates ir and hyperandrogenism. obese pcos patients tend to be overeating suggests that impaired appetite regulation might be contribute to the pathophysiology of pcos. our study is trying to observe difference of incretin between pcos and normal control to figure out whether change of incretin is involved in the pathophysiology of pcos.


Eligibility criteria:
inclusion criteria: * women at reproductive age * women with pcos and women without pcos exclusion criteria: * young women who had their menarche less than 3 years * women older than 45 years old, amenorrhea of menopause, hyperglycemia, hyperthyroidism, hypothyroidism, heart failure, lung failure, renal failure, anemia, dystrophy, gonitis
advantages and disadvantages of long term sedation in intensive care unit patients

Conditions: Critical Illness; Length of Stay; Respiration, Artificial; Intensive Care Units

Summary: the purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.

the golden standard is to sedate critical ill patients receiving mechanical ventilation with daily wake up trials. this is shown to reduce the time receiving mechanical ventilation compared to no wake up trials. we would like to study whether no sedation but only analgesics administered as bolus doses, reduce the time receiving mechanical ventilation. the study is planned as a randomised prospective study, not blinded. the control group is patients receiving sedation with daily wake up trials. the intervention group is not sedated, but receives bolus doses of analgesics (morphine). the endpoint is the time spend receiving mechanical ventilation, lengths of stay on the intensive care unit, and total lengths of stay on the hospital. we also examine the frequency of ventilator associated pneumonia and ct scans of cerebrum. also we would like to examine the long term psychological effects of sedation, we plan to send some of the patients to a post traumatic stress screening. the effect on the next of kin we plan to study with a questionnaire. as a last thing we would like to study the workload on the nurses.

Eligibility criteria:
inclusion criteria: * intubated receiving mechanical ventilation * expected to remain intubated more than 24 hours * over 18 years exclusion criteria: * raised intracranial pressure * pregnant * treatment with muscle relaxants

Keywords: drug administration schedule intensive care units length of stay respiration, artificial stress disorders, post-traumatic/etiology/*psychology critical illness/*psychology pneumonia/prevention & control hypnotics and sedatives/*administration & dosage
characterization of pseudoxanthoma elasticum

Conditions: Pseudoxanthoma Elasticum

Summary: pseudoxanthoma elasticum (pxe) is a rare multisystem disorder of autosomal recessive inheritance (omim# 264800) and an estimated prevalence between 1:25.000 and 1:100.000. pxe is characterized by calcification and fragmentation of connective tissue rich in elastic fibers. due to its high content of elastic fibers, bruch membrane in eyes of patients affected by pxe becomes thickened and calcified. the ocular phenotype is characterized by angioid streaks and peau d'orange but also choroidal neovascularizations and chorioretinal atrophy thereby in part mimicking the phenotype of age-related macular degeneration. the disease is due to mutations of the abcc6-gene coding for a transmembrane protein which is mainly expressed in the liver and kidney. it is hypothesized that abcc6 is involved in the excretion of a yet unknown factor from the liver which inhibits systemic calcification. in animal models several candidates for this factor have been identified but direct evidence for such a factor in patients with pxe is still missing. the primary purpose of this study is to further investigate the ocular phenotype of patients with pxe using multimodal imaging and functional testing to delineate the impact of bruch membrane pathology on the eye. furthermore, possible systemic anti-calcification factors, as well as associations with the vascular alterations are investigated to gain more insights into the pathogenesis of pxe..


Eligibility criteria:
inclusion criteria: * diagnosis of pseudoxanthoma elastcium based on histopathologic and/or genetic testing

Keywords: pxe phenotype eye biomarkers
a randomized-controlled study of a cognitive-behavioral intervention for children with functional abdominal pain

Conditions: Functional Abdominal Pain Syndrome; Abdominal Pain

Summary: this trial aims to compare two training programs for children suffering functional abdominal pain. these two programs are comparable in number of sessions and group sizes, but show differences in content (very focused on pain management vs. more general information and support). focus of the trial is the evaluation of "stop the pain", which has shown high effectiveness in one first trial. this time, five clinics, experienced in diagnosis and treatment of childhood chronic abdominal pain, will take part. children aged 7-12 years are eligible. the programs imply six weekly group sessions for the children and 2 parent evenings. the study group assumes that participation in "stop the pain" will reduce pain experience and will improve the children's quality of life and coping strategies - up to 12 months after training.

the trial aims to assess the efficacy of a cognitive-behavioral self-management program (intervention group, ig) compared to an equally extensive information-only control group (cg). the interventions contain 6 weekly group sessions and 2 parent meetings according to the cognitive-behavioral, manualized program "stop the pain with happy pingu". follow up per patient: 3- and 12 months. children aged 7-12 years suffering functional abdominal pain (according to rome iii criteria h2a, h2b, h2d, h2d1) are eligible. our primary hypothesis is that for patients in the ig the frequency and intensity of pain will be reduced more successfully and more sustainable than for children in the cg. secondary hypotheses state that the ig will experience a higher increase in quality of life and psychosocial well-being compared to the active cg.

Eligibility criteria:
inclusion criteria for medical screening: * aged 7-12 years * abdominal pain for at least 2 months * abdominal pain at least once per week * unclear cause for abdominal pain exclusion criteria for medical screening: * very limited german language skills * mental retardation * adjuvant psychological treatment at point of medical screening * participation in a trainingsprogram for abdominal pain in the 6 months prior to medical screening * participation in a clinical trial which possibly may have effects on abdominal pain in the 4 weeks prior to medical screening * at point of medical screening: therapy or medication for abdominal pain * presentation of sibling aged 7-12 years inclusion criteria for study participation: * pain-predominant functional gastrointestinal disorders according to rome-iii * criteria (h2a, h2b, h2d, h2d1) * informed consent for study particiaption * informed consent for audiotaping of trainings sessions * no time constraints for participation in training groups exclusion criteria for study participation: * psychiatric disorder (internalizing) with primary treatment indication * severe externalizing disorder

Keywords: functional abdominal pain psychological intervention quality of life randomized controlled trial children
myopia control effectiveness of second-generation dims spectacle lenses on fast progressing myopes

Conditions: Myopia

Summary: the purpose of this study is to examine the efficacy and performance of the variant of defocus incorporated spectacle lenses on controlling myopia progression in fast progressing myopic children.

the variant of defocus incorporated spectacle lenses (dg2) is a multifocal spectacle lens that produces myopic defocus images and corrects distance refractive errors at the same time. participants will be randomly allocated to either single vision lens group (control) or the variant of defocus incorporated spectacle lens (dg2) group (treatment). after 12 months of lens wear, the sv lens prescribed to the control group will be replaced with the dg2 lens and be monitored for another 12 months. in parallel, the dg2 treatment groups will continue their corresponding intervention for 12 months. their cycloplegic refraction and axial length will be monitored every 6 months over 2 years. the changes in refractive errors and axial length in two groups will be compared.

Eligibility criteria:
inclusion criteria: * ser: -0.75d or below in both eyes * documented history of fast progressing myopia, either in ser or al * ser progression: 0.50d/year or more * al elongation: 0.27mm/year or more * for children aged 4-6 years without past prescription forms, * 4-5 years old: myopia of -0.75d or below in both eyes * 6 years old: myopia of -1.25d or below in at least one eye, with the other eye -0.75d or below * best-corrected visual acuity (va) in both eyes: * 4 - 6 years old: 0.20 logmar (or its equivalent) or better * 7-12 years old: 0.00 logmar (or its equivalent) or better * acceptance of random group allocation and the masked study design * anisometropia of 1.50 d or less * astigmatism of 2.00 d or less exclusion criteria: * strabismus and binocular vision abnormalities * ocular and systemic abnormalities * prior experience of myopia control

Keywords: myopia defocus
study of the academic and professional course of narcoleptic patients (narcoscol-narcovitae)

Conditions: Narcolepsy

Summary: narcolepsy is a chronic, disabling, and rare sleep disorder (prevalence 1/2500) characterized by excessive daytime sleepiness and, in some patients, falls in muscle tone related to emotions (cataplexies). it often begins in childhood or in young adults. symptoms of narcolepsy are responsible for an important handicap in everyday life, and are often misunderstood by the family and professional environment. in addition, many comorbidities are associated with narcolepsy, such as depression, anxiety, or obesity. few studies have investigated the impact of narcolepsy on patients' academic background, socio-professional integration, and quality of life. narcoleptic patients may experience more difficulties in their academic and professional path than non-narcoleptic people. these difficulties would be multifactorial (related to the disease itself, comorbidities, external factors ...). as a better understanding of these determinants could help to inform patients and guide them in their choices, this study propose to establish a comprehensive inventory of educational and professional trajectories of narcoleptic patients in france in order assess the specificity of the difficulties encountered by the people concerned in their life course and to appreciate the attitude of the academic and professional circle with respect to the disease. this category 3 study (according to the french law "loi jardé") is based on the case-control model and will be conducted in all national reference and competence centers for narcolepsy and hypersomnia. it will include a population of adult and paediatric patients. it will answer questions about work and schooling in these patients.


Eligibility criteria:
inclusion criteria: the case group: * children (6 years \<age \<18 years) or adults with type 1 narcolepsy diagnosed on: * a clinic in favor of narcolepsy: excessive daytime sleepiness lasting for more than 3 months. * cataplexy and an positive multiple sleep latency test (mean sleep latency ≤ 8 min and ≥ 2 sorem) or a hypocretin dosage in the csf \<110pg / l. * patients followed in one of the centers participating in the research. the control group: * at least one person close to the case (cousins, close friends ...). * for adults: same sex as the case and if possible same age (+/- 5 years). * for minors: same sex and if possible same age (+/- 2 years). * person not suffering from narcolepsy. exclusion criteria: the case group: * patients refusing to participate. * patients who do not speak the french language (incompatible with the reading, the comprehension and the filling of the questionnaires). * patients whose diagnosis of type 1 narcolepsy is not certain and / or has type 2 narcolepsy. * patients with narcolepsy symptomatic of another neurological disease. the group controls: * person refusing to participate. * person who does not speak french (incompatible with reading, understanding and filling out questionnaires). * the brothers and sisters of the case cannot be witnesses of the study.
lung ultrasound-guided fluid therapy in pediatric intensive care unit patients

Conditions: Fluid Overload Pulmonary Edema; Fluid Overload; Pneumonia, Ventilator-Associated; Fluid Overload Without Edema

Summary: a randomized clinical trial to evaluate the effect of using pulmonary ultrasound to guide fluid therapy on distinct variables.

in this randomized clinical trial, the investigators will evaluate the effect of guiding fluid therapy by pulmonary ultrasound on the following variables: length of stay in the pediatric icu duration of mechanical ventilation oxygenation index pao2/fio2

Eligibility criteria:
inclusion criteria: * all pediatric inpatient intensive care unit admissions * signed informed consent form exclusion criteria: * cyanotic congenital heart disease * not requiring mechanical ventilation

Keywords: pediatric intensive care lenght of stay
clinical effectiveness of microwave ablation using starwave microwave generator for hepatic malignancies

Conditions: Liver Malignant Tumors

Summary: the purpose of this study is to determine the technical success rate of creating a safety margin of 5 mm or more including the tumor by performing image-guided percutaneous microwave thermal therapy using a microwave generator and antenna developed by starmed for the treatment of small liver cancer and the 1-year local recurrence rate based on follow-up imaging tests.


Eligibility criteria:
inclusion criteria: * child-pugh class a or b * patients with suspected hepatocellular carcinoma or residual/recurrent hepatocellular carcinoma of 4 cm or less on mdct, ceus, or mri performed within the last 60 days or patients with suspected metastatic liver cancer of 4 cm or less on mdct, ceus, or mri performed within the last 60 days, for whom microwave thermal ablation is being considered exclusion criteria: * in cases where there are three or more malignant liver tumors * when the maximum size of the tumor exceeds 4 cm * diffuse infiltrative type of cancer with unclear tumor boundaries * when the tumor is adhered to the central hepatic portal vein, hepatic vein, or bile duct by 5 mm or more * severe liver failure (child-pugh class c) * in cases of vascular invasion by malignant liver tumors * severe coagulopathy (platelet count below 50,000/mm³ or inr prolonged by more than 50%) * in cases of multiple extrahepatic metastases * situations where it is highly unlikely to obtain appropriate data for research purposes
acceptability among children and caregivers of amylase porridges

Conditions: Malnutrition

Summary: addition of α-amylase is considered as one of most effective solution to improve energy density of cereal based porridges (who, 2008). by adding α-amylase, the viscosity of porridges will be decreased while keeping dry matter content constant. potential positive impact is to significantly improve efficiency of wfp nutritional programmes targeting vulnerable groups suffering from acute malnutrition. the acceptance of porridges made with α-amylase is tested compared to porridges made without α-amylase among 12-36 months old children and their caregivers. acceptance is measured based on energy intake. the porridges tested consist of fortified blended supercereal (12- \<24 months) and supercereal-plus (24-36 months) based on corn soy blend (csb) extruded or drum dried, wheat soy blend (wsb), rice soy blend (rsb), all with and without α-amylase, or a commercial porridge, or eezee bar.

in total 120 caregiver-child pairs will be recruited in in a rural area in fada n'gourma province, burkina faso. in total 240 subjects are included in the study: 80 children aged 12-23.9 months with 80 caregivers and 40 children aged 24-36 months with 40 caregivers. per group (12-23.9 months or 24-36 months) 10 porridges will be prepare according to cooking instructions at central points of the villages where children are living. the caregiver will feed porridge to their children. children eat as much porridge as they like. porridge energy, micro- and macronutrient intake will be determined and porridge viscosity. children and caregivers are randomly assigned to 10 different porridges, one meal per day and 3 consecutive days per porridge. total duration is consecutively 30 days. the 120 caregivers will participate in a sensory test. at the end of the study, all caregivers will evaluate sensory of 5 out of the 10 porridges by survey, by ranking and by interview.

Eligibility criteria:
inclusion criteria: * children aged 12 to 36 months * anthropometry (for children only): muac \> 115 mm * informed signed consent of parents/caregivers * beside breastfeeding, children are used to consume complementary foods exclusion criteria: * illness or any medical complications at the recruitment time * children already enrolled in any feeding program

Keywords: young children acceptability food intake energy dense porridge
a study of mk0859 in patients with primary hypercholesterolemia or mixed hyperlipidemia (mk-0859-011)(completed)

Conditions: Hypercholesterolemia; Hyperlipidemia

Summary: this is a study to assess the safety, efficacy, and tolerability of mk0859 in patients with primary hypercholesterolemia (large amounts of cholesterol in the blood) or mixed hyperlipidemia (high levels of ldl cholesterol, triglycerides, and low levels of hdl cholesterol in blood) this is an early phase trial and some specific protocol information is in progress and not publicly available at this time. (full information is available to trial participants).


Eligibility criteria:
inclusion criteria: * patient is between 18 and 75 years of age * patient can be on a stable diet for the study * patient has a stable weight for more then 6 weeks before the study and has not participated in a weight loss program exclusion criteria: * patient has chronic heart failure or a history of heart disease * patient has blood, digestive, or central nervous system disorders * patient is pregnant or nursing * patient is hiv positive
optimal antibiotics for operated diabetic foot infections

Conditions: Diabetic Foot Infection; Surgical Wound; Antibiotic Side Effect; Infection

Summary: diabetic foot problems, especially infections (dfi), require multiple resources including iterative surgeries and amputations, long-lasting antibiotic therapies, education, off-loading and eventually revascularization and appropriate foot-ware. treatment is complicated, multidisciplinary, and marked with a high risk of recurrences. this is a retrospective and prospective cohort with side studies of pathologies and academic research questions that cannot be separated from each other. the investigators establish a retro-and prospective cohort of diabetic foot problems (ambulatory and hospitalized patients) and perform side studies to reduce the incidence of complications, and to reduce recurrences of dfi, cost and adverse events related to therapies. cohort: prospective and retrospective cohort of all diabetic foot problems with emphasis on surgical and infectious variables. trial 1 (randomized trial on residual infection after amputation): determination of the level of amputation per mri followed by a randomization concerning the duration of post-amputation systemic antibiotic therapy, if there is residual bone infection. trial 2 (randomized trial on infection without amputation): determination of the duration of systemic antibiotic therapy in diabetic foot infections without amputation of the infection.

trial 1: at enrollment (day 1), the investigator will prescribe empiric antibiotic treatment based on instructions provided in the protocol and determine the most appropriate route of administration (oral or iv) according to the patient's condition. patients will be randomized in the ratio 1:1 between 1 versus 4 days for post-amputation soft tissue infections; and between 1 versus 3 weeks if there is microbiologically proven residual bone infection/contamination in the proximal stump samples of the residual bone. trial 2: at enrollment (day 1), the investigator will prescribe empiric antibiotic treatment based on instructions provided in the protocol and determine the most appropriate route of administration (oral or iv) according to the patient's condition. patients will be randomized in the ratio 1:1 between 10 versus 20 days for post-debridement soft tissue infections; and between 3 versus 6 weeks for diabetic foot osteomyelitis post.-debridement (without amputation).

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diabetic foot infections or ischemia/necrosis with surgical amputation/disarticulation level in vicinity of mri signs of infection * at least two months of follow-up from hospitalization * patient signing to participate, including acceptance of local wound care, -off-loading and arterial re-vascularization (if clinically indicated). exclusion criteria: * at least 5 cm of distance between amputation level and infection. * any concomitant infection requiring more than 5 days of systemic antibiotic therapy * eventual osteosynthesis material not removed

Keywords: diabetic foot; osteomyelitis; amputation; antibiotics