Kornimate/medical-research-clean huggingface dataset:
salivary biomarkers of gastroesophageal reflux in infants

Conditions: Gastroesophageal Reflux in Infants

Summary: gastroesophageal reflux (ger), defined as the backflow of gastric material into the esophagus, it is a condition with a high prevalence during the first year of life. the disease from gastroesophageal reflux (gerd), a rarer condition, is defined as the presence of symptoms and complications caused by gastroesophageal reflux. for the diagnosis of gerd in infants it is necessary to perform instrumental diagnostic tests invasive. several efforts have already been made to identify diagnostic strategies non-invasive but, at the state of the art, no non-invasive biomarker has yet been found of gerd in infants. therefore, the aim of this pilot study is to identify possible biomarkers salivary gastroesophageal reflux in a population of infants with ger or gerd. infants from 2 months to the first year of life, with age, will be prospectively enrolled postmenstrual \> 40 weeks, hospitalized, with symptoms of ger or gerd and undergoing 24-hour esophageal mii-ph. saliva samples will be collected during the execution of the mii-ph of the esophagus 24 hours, at defined time points, at least 2 hours after the last meal, so as to study the circadian variations of their composition. a control group made up of healthy infants will also be enrolled and will be sampled a single saliva sample during a health assessment. the salivary ph, the buffer capacity, the electrolytes (na, k, cl, hco3) and the saliva pepsin/pepsinogen concentrations of enrolled infants. the expected results include the description of the salivary biochemical profile of ger infants vs. gerd, so that the investigators can develop non-invasive diagnostic strategies and detect personalized therapeutic treatments.


Eligibility criteria:
inclusion criteria: * infants with reflux symptoms undergoing mii-ph * consent of parents or legal representative exclusion criteria: * infants being treated with ppis * infants with postmenstrual age \< 40 weeks * infants with gastrointestinal disorders/diseases other than functional gastrointestinal disorders (fgid) * infants with otorhinolaryngological conditions potentially capable of altering salivary composition * infants with gastrointestinal malformations, such as esophageal atresia * infants with genetic, neurological, renal or endocrinological disorders * infants for whom the collection of salivary samples is not feasible
hepatic artery infusion with oxaliplatin

Conditions: Colorectal Cancer; Metastasis; Liver Cancer

Summary: hepatic artery infusion (hai) with oxaliplatin (ox), systemic 5 fluorouracil (5fu), and leucovorin (hai/ox/fu) will be implemented using an interventional radiology technique to obviate the need for initial major surgery (catheter placement) in patients who have unresectable liver metastasis from colorectal cancer. the study goal is to reduce tumor size to make possible a complete resection of all lesions. secondary goals are to reduce or eliminate the complexity usually associated with hai, to accomplish most or all of the treatment as an outpatient, to reduce costs, and to avoid the hepatotoxicity associated with hai/floxuridine (fudr). oxaliplatin has been selected because of its ease of use, known toxicology, and established efficacy in colorectal cancer.

after entry qualification and registration patients will undergo hepatic artery catheterization via interventional radiology. the catheter will remain in place for two hours while oxaliplatin is infused and then be removed. this treatment will be followed by a 48 hour infusion of 5fu and leucovorin, generally following the principle of folfox 6. these cycles of therapy will be repeated biweekly for six episodes. hepatic tumor size will be evaluated by ct scan to determine if resectability has been established as the result of tumor size reduction. if so, the patient will be offered resection of the residual lesions in an effort to achieve long term survival.

Eligibility criteria:
inclusion criteria: 1. signed consent 2. age greater than 17 years 3. stage iv colorectal cancer 4. metastasis limited to the liver considered unresectable for cure by standard methods 5. completely resected primary tumor 6. life expectancy greater than 3 years excluding cancer 7. eastern cooperative oncology group (ecog) status 0, 1, 2 8. absolute granulocyte count greater than 1500 9. platelet count greater than 100,000 10. adequate hepatic function 11. adequate renal function exclusion criteria: 1. concomitant anticancer therapy other than this protocol 2. gastroduodenal ulcer 3. pregnancy or lactation 4. last treatment for colon cancer less than 4 weeks from this protocol

Keywords: hepatic artery infusion colorectal cancer liver metastasis oxaliplatin 5 fluorouracil
safety and efficacy of the minimally invasive bentall procedure via a small right intercostal incision in patients with aortic root lesions

Conditions: Aortic Dissection; Aortic Root Aneurysm; Minimally Invasive Surgical Procedures

Summary: this study intends to include patients who had aortic root lesions and were treated with bentall surgery from january 2019 to july 2023 in the first affiliated hospital of xi'an jiaotong university. the patients will be divided into the minimally invasive group and control group according to the surgical methods: the former underwent minimally invasive bentall surgery through a small right intercostal incision; the latter underwent traditional bentall surgery through a median sternal incision. by comparing the clinical data of patients in two groups, we will investigate the effect and safety of minimally invasive bentall surgery.


Eligibility criteria:
inclusion criteria: - patients who were diagnosed with aortic root lesions and treated with the bentall procedure at the first affiliated hospital of xi'an jiaotong university from january 2019 to july 2023 will be included in this study. exclusion criteria: * previous sternotomy or aortic root surgery; * combined coronary artery disease requiring simultaneous coronary revascularization; * combined aortic arch lesions requiring simultaneous aortic arch surgery; * preoperative comorbidities with severe single or multiple organ failure; * incomplete clinical information;
evaluation of the safety and performance of magneto pe kit

Conditions: Pulmonary Embolism

Summary: this study is designed as a prospective, multi-center, multinational open labeled, single armed study to evaluate the safety and performance of the magneto pe kit.


Eligibility criteria:
inclusion criteria: * clinical signs, symptoms and presentation consistent with acute pe * pe symptom duration ≤ 14 days * cta evidence of pe * rv/lv ratio ≥ 0.9 * heart rate \<130 bpm prior to procedure * subject medically eligible for interventional procedure * age ≥ 18 and \<75 years * consent process is completed exclusion criteria: * thrombolytic use within 14 days * known bleeding diathesis or coagulation disorder * any contraindication to systemic therapeutic doses of heparin or other anticoagulants * hemodynamic collapse at presentation * decompensated heart failure * presence of extra-corporeal membrane oxygenation. * major trauma iss\> 15 within 14 days * cardiovascular or pulmonary surgery within last 7 days * fio2 requirement \> 40% or \> 6 lpm to keep oxygen saturation \> 90% * hematocrit \< 28% * platelets \< 100,000/µl * serum creatinine \> 1.8 mg/dl * inr\>2 * left bundle branch block * pap \> 70 mmhg m * imaging evidence suggests subject is not appropriate for mechanical thrombectomy * presence of intracardiac lead in right ventricle or atrium. * pacemaker or implantable cardioverter defibrillator * presence of intracardiac thrombus * anaphylactic reaction to radiographic contrast agents that cannot be pre-treated * known right- to-left shunt, * known left ventricular ejection fraction ≤ 30% * history of severe chronic pulmonary arterial hypertension * history of underlying lung disease with oxygen dependence * history of chest irradiation * history of heparin induced thrombocytopenia (hit) * female who is pregnant or nursing * current participation in another investigational drug or device treatment study * life expectancy of \< 90 days as determined by the investigator * subjects who are intubated
patient centered communication training to reduce antibiotic use in acute respiratory tract infections

Conditions: Respiratory Tract Infections

Summary: the purpose of this study is to evaluate the effectiveness of a short training program for general practitioners in patient-centered communication to reduce antibiotic prescription for acute respiratory tract infections (arti).

acute respiratory tract infections (arti) constitute the most frequent reason for seeking ambulatory care and for the prescription of antibiotics, despite the mostly viral origin of arti. antibiotic prescriptions for arti increase unnecessary drug expenditures and are the main reason for increasing drug resistance of common bacteria. evidence from intervention studies shows that merely providing physicians with guidelines and educational material for the management of acute respiratory tract infections is not enough to reduce antibiotic prescriptions for these conditions. the main reasons for antibiotic prescription in arti are non-medical and related to the physician patient relationship, patients' expectations and beliefs about the benefit of antibiotics. therefore patient-centered communication could be a promising approach to reduce the rate of antibiotic prescription in ambulatory care. comparison: general practitioners (gps) trained in patient-centered communication in addition to evidence-based guidelines for diagnosis and treatment of arti compared to gps just introduced to evidence-based guidelines.

Eligibility criteria:
inclusion criteria: * 18 years or older * symptoms of an acute respiratory tract infection for \>1 and \<28 days exclusion criteria: * patients without informed consent * not fluent in german * patients with a psychiatric disorder * patients with a recurrent respiratory system infection with antibiotic treatment in the previous 4 weeks

Keywords: acute repiratory infections antibiotic therapy patient-centred communication randomized controlled trial
a study on relationship between resected normal liver parenchymal volume（rnlv）and post-hepatectomy liver failure (phlf)

Conditions: Liver Failure

Summary: the post-hepatotectomy liver failure (phlf) is still the most worrisome complication of hepatic resection. surgeons have always been making efforts to preoperatively predict phlf using kinds of techniques, scoring systems, and variables. the investigators of this study tried to create an individual predictive model based on the variable, resected normal parenchymal volume (rnlv), then assessing the performance and value of the model in clinical practice.

the investigator launched a large sample-size and retrospective study, enrolling more than a thousand consecutive patients diagnosed with hepatocellular carcinoma (hcc) and intracholangiocarcinoma (icc) underwent hepatotectomy from the investigator's center. the primary aim of study was to identify whether there was strong correlation between rnlv and phlf, and the second aim was to further build a combination model based on rnlv and evaluate the value of predicting phlf in clinical practice. the investigators attached same importance to rnlv, compared to future liver remnant, especially for patients with massive tumors and multiple tumors. the investigators hyperthesized that rnlv could be an indicative variable for surgical safety, and help to form a diversifying method to comprehensively assess the risk of phlf preoperatively.

Eligibility criteria:
inclusion criteria: * selective hepatectomies; * histologically confirmed as hcc and icc * complete and accessible data exclusion criteria: * any history of associated liver partition and portal vein ligation for staged hepatectomy (alpps) * any history of portal vein embolism (pve) * any history of tumor rupture * emergency surgery * pathologically diagnosed with neither hcc nor icc * concomitant resection of gastrointestinal organs, spleenectomy or other organs

Keywords: resected normal parenchymal volume (rnlv) postoperative hepatectomy liver failure (phlf) future liver remnant (flr)
use of high-resolution microendoscopy (hrme) in patients with adenocarcinoma in-situ (ais) of the cervix

Conditions: Cervix Carcinoma

Summary: the goal of this clinical research study is to learn if it is possible to get high-resolution microendoscopy (hrme) images of ais tissue and/or tissue from microinvasive carcinoma right before a biopsy of the cervix. researchers also want to learn if hrme images can show the difference between cancerous tissue and normal cervical tissue.

if you agree to take part in this study, after you are in the operating room and under general anesthesia, proflavine hemisulfate solution (contrast dye) will be applied to the cervix. images will be collected with the probe from the hrme device. the hrme probe is a long thin tube with a camera at the tip. this probe will be applied to the cervix and images obtained. these images will be used for research. this should add about 10 minutes to the total time you are in the operating room. there will be no change to the planned standard-of-care colposcopy and biopsy. follow-up: a member of the research team will call you within 30 days after the procedure to ask how you are feeling and if you are having any symptoms. this call should last about 5 minutes. length of study: your active participation in this study will be over after the biopsy. this is an investigational study. the goal of this clinical research study is to learn if it is possible to get high-resolution microendoscopy (hrme) images of ais tissue and/or tissue from microinvasive carcinoma right before a biopsy of the cervix. researchers also want to learn if hrme images can show the difference between cancerous tissue and normal cervical tissue.

Eligibility criteria:
inclusion criteria: 1. any woman with a confirmed preoperative diagnosis of cervical ais, including co-existing squamous cin and/or microinvasive cancer 2. women undergoing cold knife cone (ckc) of the cervix at md anderson 3. negative pregnancy test for women of child-bearing potential 4. women who are \>/= 21 years of age and \< 65 years of age 5. ability to understand and the willingness to provide informed consent and sign a written informed consent document (icd) exclusion criteria: 1. women \ /= 65 years of age 2. women with a known allergy to proflavine or acriflavine 3. women who are pregnant or nursing 4. patients unable or unwilling to provide informed consent or sign a written informed consent document (icd)

Keywords: cervix carcinoma cervical adenocarcinoma in situ ais cervical intraepithelial neoplasia cin microinvasive carcinoma of the cervix cold knife cone of the cervix ckc high-resolution microendoscopy hrme proflavine
monitoring cellular immunity after kidney and liver transplantation

Conditions: Terminal Kidney Failure; Terminal Liver Failure

Summary: after transplantation, if insufficient immunosuppression is achieved, rejection and graft loss follows. if to much immunosuppression is given, the patient suffers risk for infections and malignancies. despite careful dosing and monitoring of drug levels, the biological effects of the immunosuppression given is difficult to predict and varies significantly. as a result, the degree of immunosuppression (or immunosuppressive status) remains unknown and clinical problems related to under- or over-immunosuppression are common. thus, a method to determine the degree of immunosuppression would be of great and direct clinical importance and the results would be improved. t cells are the principal cells of the immunesystem causing rejection. furthermore, all immunosuppressive regimes targets t cells. thus, t cell reactivity could reflect the biological effects of the immunosuppression and the immunosuppressive status. in addition, t cells are of crucial importance in the immunedefence against viral diseases. therefore, data on virus specific t cell reactivity could aid in diagnosis, monitoring and treatment of viral disease. the proposed study aim to develop a clinically useful method to monitor cellular immunity and the degree of immunosuppression after transplantation by determinations of the specific t cell reactivity to several clinically relevant viruses.


Eligibility criteria:
inclusion criteria: * all patients undergoing kidney or liver transplantation at the karolinska university hospital exclusion criteria: * abscence of informed consent

Keywords: transplantation immunological monitoring immunological risk t cell reactivity cellular immunity
cell cycle regulatory gene study in patients with myeloproliferative disorders

Conditions: Myeloproliferative Disorders; Polycythemia Vera; Essential Thrombocythemia; Myelofibrosis; Chronic Myeloid Leukemia

Summary: this study involves observing the level of cell cycle regulatory gene in patients with myeloproliferative disorders(mpd). these disorders include polycythemia vera (pv), essential thrombocythemia (et), myelofibrosis (mf) and chronic myeloid leukemia (cml). the abnormal blood and/or bone marrow cells, or materials derived from these abnormal cells, like dna, rna, protein or plasma will be used in laboratory studies. cell cycle regulatory protein such as cyclins, cyclin-dependent kinases(cdks) and cdk inhibitors(ckis) play indispensable roles in processes such as transcription, metabolism and stem cell self-renewal. mpd are a group of diseases characterized by abnormally increased proliferation of erythroid, megakaryocytic, or granulocytic cells. the pathogenesis was still unclear. detecting the level of cell cycle regulatory protein will be useful to look for the possible role in mpd and better understand the cause of mpd.

this study involves observing the level of cell cycle regulatory gene in patients with myeloproliferative disorders(mpd). these disorders include polycythemia vera (pv), essential thrombocythemia (et), myelofibrosis (mf) and chronic myeloid leukemia (cml). the abnormal blood and/or bone marrow cells, or materials derived from these abnormal cells, like dna, rna, protein or plasma will be used in laboratory studies. cell cycle regulatory protein such as cyclins, cyclin-dependent kinases(cdks) and cdk inhibitors(ckis) play indispensable roles in processes such as transcription, metabolism and stem cell self-renewal. mpd are a group of diseases characterized by abnormally increased proliferation of erythroid, megakaryocytic, or granulocytic cells. the pathogenesis was still unclear. detecting the level of cell cycle regulatory protein will be useful to look for the possible role in mpd and better understand the cause of mpd. in this study, the cell cycle regulatory message rna and protein from patients' and healthy volunteers' bone marrow and peripheral blood will be extracted and quantified by real time polymerase chain reaction and western blot. the different level of cell cycle regulatory gene between patients and volunteers and the relationship between the level and patients' clinical characteristics such as age, gender, type of disease will be analysed by spss.

Eligibility criteria:
inclusion criteria: * have a diagnosis of polycythemia vera (pv), essential thrombocythemia (et), myelofibrosis (mf) or chronic myeloid leukemia (cml) as defined by the world health organization (who) diagnostic criteria exclusion criteria: * have received treatment

Keywords: myeloproliferative disorders cell cycle regulatory protein
the effectiveness of aad and ipv to treat hospitalized infants (<2years) with acute viral bronchiolitis.

Conditions: Bronchiolitis

Summary: the purpose of this study is to investigate the effectiveness of two airway clearance techniques; intrapulmonary percussive ventilation and assisted autogenic drainage in hospitalized infants under the age of 2 with acute viral bronchiolitis.


Eligibility criteria:
inclusion criteria: * first period of wheezing * wang score between 3 and 7 * age \< 24 months * sa02\> 90% exclusion criteria: * icu patients * mechanical ventilation * use of antibiotics * use of corticosteroids * gestational age \< 34 weeks * chronic cardiac or pulmonary disease * no parental consent

Keywords: bronchiolitis wang score sa02 airway clearance techniques intrapulmonary percussive ventilation assisted autogenic drainage
hardware preservation in management of infected non united or delayed united fractures of long or short bones by debridement and local calcium sulfate loaded by antibiotics

Conditions: Infected Non Union and Delayed Union in Fractures of Both Long and Short Bones

Summary: * diagnosis of infection based on elevated serum markers of infection (esr, crp), discharging sinus, preoperative radiographs suggestive of bone infection and radiological findings . \[6\] * infected nonunion mean the bone has previous fracture , the bone not healed may be one of the reasons it didn't heal because there is sub-acute infection , there is low grade colonization into the bone or around the wound preventing the bone from healing , it different from infected fracture which occur fairly acutely. \[6, 7\] * infected nonunion treated with systemic antibiotics alone, without using local antibiotic delivery systems associated with higher recurrence and reoperation rates. \[7\] * this led to the development and use of medical-grade calcium sulfate (cs), cs facilitates osseous healing in an osteoconductive fashion by filling the bone void and preventing fibrous tissue


Eligibility criteria:
inclusion criteria: * patient at any age and of any sex with infected non united fracture of long or short bones exclusion criteria: * presence of previous vascular injury or pathological fracture * refusal to participate * inability to provide informed consent * allergy or sensitivity to vancomycin or tobramycin * patient with impaired renal function * patient with hypercalcemia
improving the stop-bang screening questionnaire for patients with sleep apnea

Conditions: Sleep Apnea; Metabolic Syndrome

Summary: the study is being conducted to test the ability of a simple questionnaire to detect mild, moderate or severe obstructive sleep apnea. the investigators are also investigating whether adding the size of the neck and waist can add to the accuracy of the questionnaire. the study will be conducted at the center for sleep medicine at tufts medical center. the investigators hope to enroll 250 patients in our study at tufts medical center.

we will complete a 12 item questionnaire and data sheet with the study subjects based on their responses and 2 measurements specified below, right before application of a study the start of their sleep study called "polysomnography". if available, we will also use information from the subjects medical record, including information regarding a history of diabetes (blood sugar that is too high), high blood pressure and laboratory data such as blood sugar and blood lipids (fats in the blood). we will record this information for research purposes. the 2 measurements performed for research purposes consist of the size of the neck and waist using a flexible tape measure. after the sleep study, we will also use results from that study in this research. we expect the subjects study participation to be completed in 30 minutes or less. there will be no follow up. if a participant cannot complete the sleep study for any reason, the study team may decide to withdraw the subject's participation without further notice. the study will be open for participation from june 2012 through november of 2012.

Eligibility criteria:
inclusion criteria: * referral to the sleep center for a diagnostic study

Keywords: osa metabolic syndrome apnea-hypopnea index oxygen desaturation index