Kornimate/medical-research-clean huggingface dataset:
medicine abuse headache

Conditions: Migraine

Summary: in patients with moh, we will evaluate the impact of educative telephone coaching on the number of days with headache over the month preceding the appointment. the educative coaching will be administered by a nurse, during a single phone call and prior to the medical visit

in tertiary centers, it is not unusual for patients to wait for 6 months for a medical appointment. this clinical trial is monocentric, open, randomised. in the first arm, the patients will receive educative telephone coaching at month 2 by the nurses, over the phone. in the second arm, the patients will not receive any educative telephone coaching before the appointment with the neurologist. all patients will complete "quality of life" questionnaires at month 1 and months 6, complete a migraine agenda during the length of the study and have a medical appointment around month 6. the primary outcome will be the efficacy of such educative telephone coaching, administered before the medical appointment in the chronic pain center, in bordeaux. it will be measured by the number of days with headache over the month preceding the appointment.

Eligibility criteria:
inclusion criteria: * adults, male or female, \> 18 years old * patients with a presumptive medication overuse headache diagnostic (\>15 days/month with migraines, \> 10 days/month intake of crisis treatment) * persons calling the chronic pain center in bordeaux and asking for a medical appointment * informed and written consent, dated and signed by the patient and the investigator prior to any study related procedure exclusion criteria: * patients with a differential diagnostic (other primitive headaches and secondary headaches) * persons non affiliated to a social security system * persons who refuse to participate in the study.

Keywords: education, quality of life
functional outcomes and the restoration of range of motion after the arthroscopic complete posterior knee capsulotomy in patients with extension deficit of the knee

Conditions: Knee Disease; Knee Deformity

Summary: the restriction of the range of motion is one of the most frequently encountered complications after the surgical procedures of the knee. while the flexion deficit is relatively well tolerated, even the small extension deficit significantly impairs the quality of life due to the increased stress on the patellofemoral joint, functional leg length discrepancy and the subsequent mechanical overload in the hip joint, lumbar spine and contralateral knee. in the majority of cases the guided physiotherapy protocol is sufficient to restore the full range of motion. in refractory cases, the treatment consists of the thorough arthrolysis of the affected knee, aiming to excise the adhesions, osteophytes and orthopaedic implants interfering with the knee range of motion. however, as the extension deficit persists, the contracture of the knee posterior capsule may develop and the sole debridement of the knee may be insufficient. in such rare cases the treatment consists of the posterior capsulotomy of the affected joint. traditionally, this procedure was performed through the open approach. however, with the growing indications toward the arthroscopic procedures seen in recent decades, even such salvage procedures like posterior knee capsulotomy are increasingly performed through the arthroscopic approach. the aim of this study is to assess the outcomes of the arthroscopic complete posterior capsulotomy of the knee basing on the knee range of motion and functional outcomes. the primary outcome consists of the knee extension, whereas the secondary outcomes include knee flexion, knee total range of motion, the international knee documentation committee questionnaire and the knee injury and osteoarthritis outcome score.


Eligibility criteria:
inclusion criteria: * above 18 years old, * symptomatic asymmetric extension deficit \>3 degrees, * impossibility to restore the full knee extension after 6 months of guided physiotherapy. exclusion criteria: * restoration of full knee extension after the initial knee arthrolysis, * active knee inflammation, * non-adherence of the patient to the treatment protocol. * contractures due to extra-articular reasons, * less than 6 months since the last surgical procedure affected knee.
randomised study of epidural vs mpca morphine vs tapp in laparoscopic sigmoidectomy

Conditions: Sigmoidal Tumour

Summary: the investigators would study the control of postoperative pain with peridural catheter, morphine pca ev or transabdominal block.


Eligibility criteria:
inclusion criteria: * age more than 18 * laparoscopic sigmoidectomy * informed consent firmed exclusion criteria: * asa iv * urgent surgery * sigmoid tumour stage iv * cronic pain treatment * no informed consent firmed * paliative surgery

Keywords: peridural catheter morphine pca transabdominal block laparoscopic sigmoidectomy
yod-risoco: social cognition and risk-taking behaviour in patients with young-onset dementia

Conditions: Young-onset Dementia

Summary: the goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (yod). the investigators want to * examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant yod patients, patients with frontal brain injury, non-behavioural yod patients and healthy controls. * examine if there is a relation between social cognition tests and measures of risky behaviour. participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.


Eligibility criteria:
inclusion criteria: all subjects * sufficient command of the dutch language * in possession of a driver's license with any driving experience throughout life * age 18 to 65 bvyod subjects * probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases fdg/pib-petscans, csf biomarkers or genetic counseling were discussed. * nosological diagnosis of bvftd or bvad non-bvyod subjects * probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases fdg/pib-petscans, csf biomarkers or genetic counseling were discussed. * yod subtypes other dan bvftd or bvad, such as amnestic variant ad. frontal brain injury subjects - neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients). exclusion criteria: all subjects * suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness yod subjects: - presence of premorbid severe neurological or psychiatric pathology, non-related to dementia. frontal brain injury subjects: - presence of serious psychiatric disorders or other neurological comorbidities. healthy control subjects: * presence of serious psychiatric disorders * history of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).
duloxetine versus placebo in the treatment of patients with diabetic peripheral neuropathic pain in china

Conditions: Diabetic Neuropathies

Summary: to determine if duloxetine 60mg up to 120mg daily can work in treating pain from diabetic neuropathy.


Eligibility criteria:
inclusion criteria: * have pain due to bilateral peripheral neuropathy caused by type i or type ii diabetes with the pain beginning in the feet and present for at least 6 months. * may not be pregnant and agree to utilize medically acceptable and reliable means of birth control during participation in the study. * score of 4 or greater on the brief pain inventory on the 24-hour average pain item. exclusion criteria: * glycosylated hemoglobin (a1c) \> 12% * severe hepatic disease * history of substance abuse or dependence within the past year, excluding nicotine and caffeine. * serious or unstable cardiovascular, hepatic (acute liver injury such as hepatitis or severe cirrhosis), kidney, respiratory, blood disorder, seizure disorder, problems with peripheral vascular disease, or other medical conditions or psychiatric conditions that would hinder your participation or likely to lead to hospitalization during the course of the study. * taking monoamine oxidase inhibitor (maoi) within 14 days of starting the study or the potential need to take during or within 5 days after discontinuation from the study. * treatment of fluoxetine within 30 days of starting the study. * unstable blood sugar control and uncontrolled or poorly controlled hypertension.
danish multicenter study of adalimumab in spondyloarthritis

Conditions: Spondyloarthritis

Summary: spondyloarthropathies (spa) are often diagnosed with a considerable delay (often 8-10 years from symptom onset), because the available clinical, biochemical and radiological methods are not sufficiently sensitive. tnf-a antagonists have recently been introduced for treatment of spa, and current data indicate a higher efficacy than previously available therapies. the improved treatment options have increased the need for improved methods for diagnosis, monitoring and prognostication of these diseases, so that the efficient therapies can be initiated at the optimal time point and monitored optimally. magnetic resonance imaging (mri) and a number of biomarkers are promising, but not yet sufficiently studied, methods for this.

see brief summary

Eligibility criteria:
inclusion criteria: 1. diagnosis of spondyloarthritis according to the european spondyloarthritis study group (essg) criteria 2. clinical active disease, defined as a basdai score \> 4 despite concurrent nsaid therapy 3. presence of sacroiliitis on conventional radiography or mri. 4. among other issues: age \>18 years; adequate birth control; no contraindications for anti-tnfa-therapy, no previous tnfa-antagonists exclusion criteria: 1. previous tnfα inhibitor therapy 2. treatment with disease modifying anti-rheumatic drugs within 4 weeks before screening 3. oral, intraarticular, intramuscular or intravenous glucocorticoid within 4 weeks before screening 4. pregnancy or lactation 5. hiv, hepatitis b or c, tuberculosis, other infections 6. malignancies 7. other serious concomitant diseases (uncontrolled/severe kidney, liver, haematological, gastrointestinal, endocrine, cardiovascular, pulmonary, neurological ore cerebral disease (including demyelinating disease) 8. contraindications to anti-tnfa-therapy 9. contraindications to mri
ultrasound and immunological findings in patients with shoulder injury related to vaccine administration (sirva)

Conditions: Shoulder Injury Related to Vaccine Administration; Erosion, Localized

Summary: accidental vaccine injection into adjunct shoulder structures can cause tissue damage, termed shoulder injury related to vaccine administration (sirva). the immunopathological mechanisms and consequences of sirva are unknown. the study assesses the clinical and immunological consequences of an influenza vaccine if accidentally administered in periarticular space.


Eligibility criteria:
inclusion criteria: * participation at a local vaccination campaign * shoulder pain \>3 days after vaccination exclusion criteria: * no vaccine received * preexisting shoulder pathology
the effect of lesion characteristics in mrgfus on tremor in essential tremor and parkinson's disease

Conditions: Tremor

Summary: the study will investigate essential tremor and parkinson's disease patients who underwent magnetic resonance guided focused ultrasound surgery (mrgfus). we will evaluate the effect of lesion characteristics on tremor and on quality of life after the procedure as compared with the baseline prior to the procedure.

the purpose of the study is to investigate the effect of lesion characteristics in exablate transcranial magnetic resonance guided focused ultrasound surgery (mrgfus) of the vim thalamic nucleus. clinical measures will be used to study patients suffering from medication-refractory tremor, essential tremor or idiopathic parkinson's disease. this study is designed as a prospective, observational, and clinical study. assessments will be made before and after mrgfus for; clinical tremor relief, quality of life (qol) improvements, assessment of adverse events, and correlations of these measures with the size and shape of the lesion and the surrounding edema .

Eligibility criteria:
inclusion criteria: * men and women, between 18 and 80 years. * patients who underwent the mrgfus procedure. * patients who are able and willing to give consent and able to attend all study visits and radiologic follow-up examination by mri. * a diagnosis of et or idiopathic pd as confirmed from clinical history and examination preformed by a movement disorders neurologist. * et patients: tremor severity score of greater than or equal to 2 in the treated hand/arm as measured by postural or action item on the clinical rating scale for tremor (crst). * pd patients: tremor severity score of equal or greater than 3 on either item 20 or item 21 of motor part in the unified pd rating scale (updrs). * substantial disability in the performance of at least two daily activities from the disability subsection of the scales updrs for pd patients or crst for et patients. * the patient must have a history of an unsatisfactory response to medical management. all patients will need to have tried and failed at least one drug. alternatively, a patient may also qualify if tremor-suppressing medications are contraindicated due to a coexisting medical condition or drug allergy. * stable doses of all medications for 30 days prior to study entry. exclusion criteria: * patients which have not completed the mrgfus procedure. * patients which were diagnosed during the trial with additional diagnoses that can affect motor function, quality of life and symptoms of tremor.

Keywords: magnetic resonance guided focused ultrasound tremor essential tremor parkinson's disease
evaluation of clinical efficacy of herbal compound in the treatment of nslbp

Conditions: Low Back Pain

Summary: the aim of this randomized controlled trial was to explore the clinical efficacy and safety of hxtl in the treatment of nslbp based on tcm principles and to compare the clinical outcomes of different syndromes of nslbp with celecoxib.in this study, 80 patients with nslbp were recruited and randomly grouped to use tcm compound and celeoxib respectively for intervention. the pain status and lumbar function use scale of patients were scored before intervention, 1 week, 2 weeks and 3 weeks after intervention, and the adverse reactions of patients after medication were recorded, and the clinical efficacy of the two groups of patients was compared finally.


Eligibility criteria:
inclusion criteria: * a. patients with low back pain who were seen between january 1, 2022 and june 16, 2023 were included; * b. meet the diagnostic criteria of nslbp; * c. the age range was 20-90 years old; * d. agree to participate in the study and sign the informed consent; exclusion criteria: * a. those who are unable to communicate normally, such as those suffering from mental and cognitive diseases, and cannot cooperate with the treatment; * b. pregnant or lactating women; * c. patients who are allergic to the treatment components or sulfonamides; * d. patients with a history of coronary artery bypass grafting; * e. patients with active gastrointestinal ulcer or bleeding; * f. patients with severe heart failure; * g. patients with hepatic and renal insufficiency.
effect of head position during thyroidectomy on postoperative cognitive functions

Conditions: Thyroid; Carotid Doppler; Cerebral Perfusion

Summary: the aim of our study is to observe the effect of head-neck position of patients scheduled for thyroidectomy, on carotid artery blood flow, regional cerebral oxygen saturation measured using near-infrared spectroscopy technology, and postoperative cognitive dysfunction.


Eligibility criteria:
inclusion criteria: * undergo a total thyroidectomy operation * asa i-ii * euthyroid patients in the preoperative period exclusion criteria: * hemoglobin\< 8 g / dl * hypertension * hyperlipidemia * pregnancy * patients diagnosed with diabetes mellitus * cerebrovascular insufficiency * known carotid artery lesion * metabolic diseases * any intracranial pathology present * surgeries exceeding 180 minutes

Keywords: head position cerebral oxygenation postoperative cognitive dysfunction
an observational chart review study to describe the real-world outcomes and use of avelumab in combination with axitinib for treatment of patients with arcc in the uk

Conditions: Advanced Renal Cell Carcinoma

Summary: an observational chart review study to describe the real-world outcomes and use of avelumab in combination with axitinib for treatment of patients with advanced renal cell carcinoma in the united kingdom.


Eligibility criteria:
inclusion criteria * patients must meet all of the following inclusion criteria to be eligible for inclusion in the study: * patients with a documented diagnosis of arcc. * patients aged ≥18 years old at the index event date. * patient initiated on treatment with avelumab in combination with axitinib ( ≥1 dose) on or after 1st august 2019. exclusion criteria * patients meeting any of the following criteria will not be included in the study: * patients who received avelumab in combination with axitinib as part of a clinical trial * patients initiated on avelumab in combination with axitinib less than 12 months from the end of data collection. * patients who are known to have opted out of participation in any research
effect of micronutrient supplementation on nerve conduction velocity in t1d- rct

Conditions: Type 1 Diabetes

Summary: type 1 diabetes can complicate to peripheral neuropathy due to preferential involvement of small unmyelinated nerve fibers (pain and temperature sensation) followed by myelinated nerve fibers (vibration and proprioception). the search for diabetes in youth study found diabetic neuropathy in 7% of t1d youth. the clinical form of peripheral neuropathy is rare in childhood and pathophysiological changes begin during childhood and accelerate in puberty. adolescents with these changes can be picked up more reliably by electrophysiological studies than by clinical examination. nerve conduction studies are the gold standard diagnostic tests for detection of peripheral neuropathy. role of vitamin b12 in nerve regeneration is well known while causal association of vitamin d deficiency in type 1 diabetes and its role in axonal degeneration is also reported. the previous ongoing studies from authors' group have shown relationship between poor oral iron intake and subclinical neuropathy in children with type 1 diabetes (manuscript in submission). the present randomised clinical trial is aimed at assessing vitamin b12, vitamin d and iron supplementation for improvement of nerve conduction velocities in children and youth with type 1 diabetes.


Eligibility criteria:
inclusion criteria: 1. children/ parents/ youth willing to participate in the study with an informed consent/ assent. 2. children/ youth age \> 10 years 3. diabetes duration \> 2 years 4. diagnosed with type 1 diabetes exclusion criteria: 1. age \< 10 years 2. diabetes duration \< 2 years 3. children/ youth receiving vitamin b12, vitamin d and/or oral iron supplements 4. children/ youth with any other disease condition involving nerve or muscle function 5. children/ parents/ youth not willing to consent to participate in the study.

Keywords: diabetic neuropathy children and youth with type 1 diabetes vitamin b12 vitamin d oral iron nerve conduction velocity
renin angiotensin aldosterone system in septic kids

Conditions: Sepsis; Acute Kidney Injury Due to Sepsis; Acute Kidney Injury (Nontraumatic)

Summary: prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with acute kidney injury (aki) vs without aki. blood samples and renal ultrasound will be collected on sequential days for septic subject and one time for the healthy patients. enzyme-linked immunosorbent assays (elisa) with be run on serum plasma to compare the renin-angiotensin-aldosterone system (raas) between groups.

prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with aki vs without aki. powered to collect 74 patients total (37 sepsis,37 healthy) with enrollment ratio 1:1 and expected different of 50% in renin levels, this provides 80% power at an alpha of 0.05. sepsis identified as pediatric sequential organ failure assessment (psofa) \>/= 2 + infection and/or phoenix sepsis criteria. collecting blood samples on subsequent days of hospitalization. for healthy patients, a one-time blood draw will be obtained . renal ultrasound will be performed on day 1, 2 and 3 of hospitalization. blood will be collected and plasma stored at -80 degrees celsius. plasma thawed in batches and elisas for raas components. demographic data will be collected.

Eligibility criteria:
inclusion criteria: * pediatric patients age 1 days - 18 years old with sepsis or age 1 day - 18 years and healthy. exclusion criteria: * -pre-existing end stage renal disease (esrd), chronic renal failure (crf), home use of angiotensin converting enzyme inhibitor(ace) or angiotensin receptor blocker(arb) medications, pre-existing congestive heart failure (chf), and unrepaired congenital heart disease
effectiveness of the skills program in the management of psychiatric disorders

Conditions: Psychiatric Disorders

Summary: epidemiological studies show that one person in eight suffers from at least one psychiatric disorder. mental health is therefore a major public health issue, and care for these disorders must continue to be improved. the management of mental disorders has long followed the traditional categorical approach of developing a treatment for a given disorder. however, researchers have recently pointed out the limits of this approach in the field of mental health. they highlight the large number of co-morbidities, the existence of aspecific disorders and the intra-diagnostic heterogeneity of patients. these factors have led them to develop a transdiagnostic approach, which focuses on the mechanisms common to the various disorders in order to treat them at the same time and thus reduce the cost of treatment.


Eligibility criteria:
inclusion criteria: * male or female ≥ 18 years of age * have at least one diagnosis of a psychiatric disorder * be able to carry out psychotherapy sessions * have been on stable psychiatric medication for 30 days * written informed consent obtained from the participant * be affiliated to a social security scheme or equivalent exclusion criteria: * cognitive deficits marked by a score above the 10th percentile for one or more tests in the assessment history. * persons deprived of liberty by judicial or administrative decision; persons under legal protection: guardianship or curatorship * presence of a severe depressive episode * be engaged in psychotherapeutic work elsewhere * presence of a state of excessive deficit, making psychotherapy impossible * presence of psychic decompensation (e.g. delusions) making psychotherapy impossible