Kornimate/medical-research-clean huggingface dataset:
cell surface marker expression in autoimmune diseases

Conditions: Systemic Lupus Erythematosus; Sjogren's Syndrome; Multiple Sclerosis; Systemic Sclerosis; Crohn's Disease; Ulcerative Colitis; Inflammatory Myositis

Summary: this study is designed to explore the expression of cell-surface markers in the following seven disease areas: (a) systemic lupus erythematosus, (b) sjogren's syndrome, (c) multiple sclerosis, (d) systemic sclerosis, (e) crohn's disease, (f) ulcerative colitis and (g) inflammatory myositis.


Eligibility criteria:
inclusion criteria: 1. male or female participants 19 years of age or older. 2. participant or legal surrogate able and willing to provide written, informed consent. 3. participant is, or has been undergoing care for one of the specified diseases in a participating centre with a confirmed clinical diagnosis of the specified disease. 4. participant has or will provide the relevant peripheral blood (required) and normal practice tissue specimens (if available). 5. participant has one of the following target auto-immune or inflammatory diseases diagnosed according to local clinical practice guidelines: 1. crohn's disease 2. inflammatory myositis 3. multiple sclerosis 4. sjogren's syndrome 5. systemic lupus erythematosus 6. systemic sclerosis 7. ulcerative colitis exclusion criteria: 1. participants receiving investigational therapy within 30 days or 5 half-lives, whichever is longer, prior to enrolment. 2. participants suffering from any additional disease that may interfere with the biomarker signals as per the investigator's discretion.
predictive biomarker for endoscopic therapy in chronic pancreatitis

Conditions: Chronic Pancreatitis

Summary: this is an observational prospective study to develop predictive biomarkers for pain response in participants with chronic pancreatitis scheduled for endoscopic therapy. participants will undergo baseline assessments including electroencephalography (eeg), quantitative sensory testing (qst), and psychosocial questionnaires. response to endoscopic therapy will be assessed at approximately 3, 6, 12 and 18 months post-procedure using questionnaires.


Eligibility criteria:
inclusion criteria: * adults older than 18 years; * cambridge iii or iv criteria for chronic pancreatitis (cp); or m-annheim criteria for definitive chronic pancreatitis; * scheduled for endoscopic therapy for ductal obstruction (may include lithotripsy, pancreatic duct dilation, or stone extraction to facilitate successful stenting) as part of routine clinical care based on multidisciplinary review; * pain present for ≥ 3 days per week for ≥ 3 months; * average pain over the last week ≥ 4 on a 11-point numeric rating scale (nrs). exclusion criteria: * chronic pain syndrome other than cp; * episode of acute pancreatitis within 2 months of enrollment; * endoscopic therapy including endoscopic retrograde cholangiopancreatography (ercp), endoscopic ultrasound (eus) guided celiac plexus block or pancreatic surgery \< 6 months prior to enrollment; * active illicit drug use (excludes marijuana use); * american society of anesthesiologists classification \> 3; * immune-mediated pancreatitis or associated pancreatic neoplasms * major neurological disease such as stroke, uncontrolled epilepsy, dementia * diagnosis of schizophrenia * chronic benzodiazepine use. use of short acting benzodiazepine on as needed basis is acceptable if participant is able to hold benzodiazepine prior to eeg recording. * pregnancy
usability and ergonomic evaluation of self-positioning system for retinal imaging

Conditions: AMD Population - Intermediate or Advanced AMD; DR Population- With or Without Diabetic Macular Edema

Summary: the purpose of the study "usability and ergonomic evaluation of self-positioning system for retinal imaging" is to enable self-operation of a monitoring device in home-simulated environment

one of the main challenges in developing a retinal imager is to design it to be self-operated by elderly patients in their home setting the study's objective is to explore ergonomic solutions that will allow the user to perform imaging on their own. the study will be done in a home-simulated environment using a dedicated ergonomic system (termed "paf" - positioning and fixation system) that stimulates the retinal imager and enables to record the tested subject using standard cameras. the prototype doesn't include the retinal imager and does not include any imaging capabilities aside from standard means of photography subjects will be evaluating for positioning accuracy and comfort by comparing different methods. pupil position will be recorded using commercial off the shelf cameras when the subject is performing simple ergonomic tasks while looking at a screen presenting images.

Eligibility criteria:
inclusion criteria: * age ≥ 65 * able to understand and sign the informed consent form * ability to communicate verbally * amd (interim and advanced) or diabetic retinopathy (with and without dme) exclusion criteria: * visual acuity \>=20/200 in the better eye
noradrenaline infusion versus phenylephrine infusion in improving serum lactate level in hipec

Conditions: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Summary: abg parameters are changed during hipec, we tried to find comparison between noradrenaline and phenylephrine in optimizing abg parameters that reflects organ perfusions especially serum lactate

arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/l indicates poor tissue perfusion. serum lactate could be measured at abg or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at abg during the stage of hipac in managing abdominal cancer patients.

Eligibility criteria:
inclusion criteria: * cancer patients enrolled for hipec exclusion criteria: * drug sensitivity
imaging of prostate cancer using two-dimensional mr spectroscopy and diffusion tensor imaging

Conditions: Prostate Lesions

Summary: the goal is to develop mr imaging techniques to improve delineation of cancer extent, and to improve differential diagnosis between prostate cancer and benign prostate hyperplasia or other benign diseases.


Eligibility criteria:
inclusion criteria: 1. a male older than 21 years of age and under age of 80, 2. either a normal healthy volunteer; a patient who has confirmed prostate cancer and decided to receive prostatectomy; or a patient who has persistent elevated psa higher than 4.0 ng/ml, and with a prior benign biopsy scheduled to receive the second biopsy. exclusion criteria: 1. unwilling to give informed consent, 2. have implanted prosthetic heart valves, pacemaker, neuro-stimulation devices, surgical clips (hemostatic clips) or other metallic implants, 3. have engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or have imbedded metal fragments from military activities, 4. have received orthodontic work involving ferromagnetic materials, 5. claustrophobic, 6. unable to lie down still for 60 minutes.
longterm safety study of bema buprenorphine in subjects with chronic pain

Conditions: Pain; Low Back Pain; Osteoarthritis; Neuropathic Pain

Summary: the purpose of this study is to determine whether bema buprenorphine is safe in the treatment of chronic pain.

this is an open label study of up to approximately 52 weeks duration to assess the safety and effectiveness of bema buprenorphine in the management of moderate to severe chronic pain. bema buprenorphine is an oral transmucosal form of the opioid analgesic, buprenorphine hydrochloride, intended for application to the buccal mucosa. buprenorphine is a synthetic opioid that is classified as a partial μ-receptor agonist and a schedule iii controlled substance in the united states.

Eligibility criteria:
inclusion criteria: * male or non-pregnant and non-nursing female aged 18 or older * history of moderate to severe chronic pain: 1. subjects completing study bup-301 (low back pain) or 2. osteoarthritis or neuropathic pain, or subjects not completing study bup-301 (low back pain), pain for ≥3 months with a pain intensity ≥5 \[11 point nrs\] reported at the titration period day 0/1 visit following a washout period (opioids, nsaids, and muscle relaxants) of approximately 12 to 24 hours and currently taking ≤60 mg oral morphine equivalent/day (including opioid-naïve) for 1 week or longer * stable health, as determined by the investigator, on the basis of medical history, physical examination, and laboratory results so as to comply with all study procedures * female subjects of childbearing potential must be using a recognized effective method of birth control * written informed consent obtained prior to any procedure being performed exclusion criteria: * cancer related pain * reflex sympathetic dystrophy or causalgia (complex regional pain syndrome), acute spinal cord compression, cauda equina compression, acute nerve root compression, meningitis, or discitis * surgical procedure for pain within 2 months, or nerve/plexus block within 4 weeks, prior to titration period day 0/1 visit * history of severe emesis with opioids * clinically significant sleep apnea in the judgment of the investigator

Keywords: buccal soluble film
tbs over dlpfc in elderly refractory depression

Conditions: Major Depression

Summary: the study aim to examine the effect of thea-burst stimulation over bilateral dorsolateral prefrontal cortex (dlpfc) among patients with lld on mood condition and relevant biomarkers.

thea-burst stimulation (tbs) is a novel form of rtms, providing greater modulation effect on neural activity. so far, no study was conducted to use tbs as treatment in lld. therefore, we aim to examine the effect of tbs over bilateral dorsolateral prefrontal cortex (dlpfc) among patients with lld on mood condition and relevant biomarkers. the study used a two-arm, parallel, double-blind, randomized, and sham-controlled design. we plan to enroll sixty patients with lld, thirty for active intervention and thirty for sham-controlled group. an magstim rapid2 stimulator with eight-figure coil was used for stimulation. location of brain area are based on bilateral dlpfc. 3-pulse 50-hz bursts was given every 200ms (at 5 hz) and an intensity of 80% active motor threshold was settled. we initially used ctbs (continuous tbs) over right dlpfc with 120-s train of uninterrupted bursts (1800 pulses) in each session per day. after that, we continuous use itbs (intermittent tbs, itbs) over left dlpfc with 2-s train of bursts was repeated every 10 s for a total of 570 s (1800 pulses). each patient received daily stimulation for two weeks with total ten sessions. the primary outcomes were change of depression severity including response and remission rate. secondary outcome were biomarkers related to depression. assessments were administered at baseline, immediately after 5 and 10 sessions of stimulation, and 3 months after the completion of stimulation.

Eligibility criteria:
inclusion criteria: * aged 60 to 85 years * major depression disorder * under a stable dose of all psychotropic medication during the stimulation period. exclusion criteria * having any current psychiatric comorbidity or history of substance dependence. * having active suicidal ideation currently. * having severe physical illness, recent and/or current unstable medical disorders. * having history of cancer or chemotherapy. * dementia or mmse\<24. * having tms contraindicated (seizure disorder, history of seizures, metal in the head, pacemakers, history of craniotomy)
digital treatment of irritable bowel syndrome (ibs)

Conditions: IBS - Irritable Bowel Syndrome

Summary: the aim of this work is to identify whether the digital treatment program mage-tarmskolen has an effect on patients with ibs. our secondary objectives is to address multiple aspects of digital treatmtent success of the different modules. the patients will be randomized to one of four arms and will be delivered different kinds of digital treatment. all patients will have access to ask questions to a registered dietitian. primary end point is the proportion of patients with treatment success in the low fodmap, behavioral therapy or both groups, versus the patient education group (sham). treatment effect is defined as an improvement of 50 points or more on the ibs severity scoring system at 3 months after treatment start compared to the score before treatment.


Eligibility criteria:
inclusion criteria: - diagnosed with ibs in the primary or secondary healthcare service. * patients aged 18-70 years with ibs defined by the rome iv criteria: recurrent abdominal pain, on average at least 1 day per week during the previous 3 months, that is associated with two or more of the following: i) defecation, either increased pain or pain relief, ii) change in stool frequency, iii) change in stool form (appearance) * all participants \>50 years: colonoscopy within the last 5 years prior to study entry excluding other pathology * bank-id and access to tablet, pc or smart phone. * no known presence of: symptomatic endometriosis, diabetes type 1 and 2, malignant disease (excluding basalioma), * no history of: severe psychiatric disorder, alcohol or drug abuse, inflammatory bowel disease, microscopic colitis, diverticulitis or ileus, major abdominal surgery (except appendectomy, cholecystectomy, caesarean section, and hysterectomy) * no "red flags'' indicating severe undiagnosed disease: night sweats (repeated episodes of extreme perspiration that may soak nightclothes or bedding), unintentional weight loss (≥ 4.5 kilograms, or 5% of normal body weight) over less than 6 months without knowing the reason, or blood in stool * not pregnant * ability to comply with protocol requirements

Keywords: digital treatment
combined effect of therapeutic ultrasound and trans cutaneous electrical nerve stimulation on endometriosis

Conditions: Endometriosis

Summary: this study will be conducted to investigate the combined effect of therapeutic ultrasound and transcutaneous electrical nerve stimulation (tens) on relieving adhesions and pain related to endometriosis.

endometriosis affects 10-15% of reproductive-age women, causing pelvic pain and infertility. while laparoscopy is the primary treatment, it has risks. medications are also used but often have side effects. complementary therapies like acupuncture, yoga, and physical therapy modalities show promise. therapeutic ultrasound has demonstrated effectiveness in managing chronic pain and adhesions associated with endometriosis. transcutaneous electrical nerve stimulation (tens) has shown positive results in pain relief and potentially improving uterine conditions for implantation. this study aims to investigate the combined effect of therapeutic ultrasound and tens on endometriosis-related adhesion and pain, providing valuable information for physical therapists in treating this condition.

Eligibility criteria:
inclusion criteria: * forty-five women clinically diagnosed by the gynecologist with endometriosis will be included in the study. * abdominal wall endometriosis will be diagnosed via color doppler ultrasonography. * their ages will range from 25 to 35 years old. * their body mass index (bmi) will be ranged from 25 to 35 kg/m2. * all patients have reported mild to moderate endometriosis symptoms such as (chronic pelvic pain (cpp), dysmenorrhea, dyspareunia, pain with bowel movements and urination and excessive bleeding) as recorded by endometriosis health profile questionnaire (ehp30). * all patients use continuous hormonal treatment for at least 3 months. exclusion criteria: * severe endometriosis which is diagnosed by the gynecologist. * pregnancy, peacemaker, epilepsy, cardiac arrhythmia, cancer, acute inflammatory pelvic disease. * use of injectable hormonal therapy within the previous 6 weeks. * patients with contraindication of ultrasound (patients with reduced sensation to pain and/or heat, local malignancy, local acute infection and over areas of thrombosis or other vascular abnormalities). * cognitive deficiency and difficulty to understand instructions or use the instruments.
prediction of diverse glucocorticoids toxicity outcomes

Conditions: Inflammatory Rheumatism; Polymyalgia Rheumatica; Giant Cell Arteritis; Idiopathic Inflammatory Myopathies; ANCA Associated Vasculitis; Systemic Autoimmune Disease

Summary: to date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy. in patients with inflammatory rheumatic disorders requiring prolonged glucocorticoid therapy, such tool could be useful to adapt first-line treatment decisions (in daily practice and in future clinical trials). the main objective of the study is to identify routine clinical, biological and dxa baseline characteristics predictive of the occurrence of clinically relevant complications of glucocorticoid therapy at 1 year, in order to propose a predictive score.


Eligibility criteria:
inclusion criteria: * life expectancy \> 1 year. * indication to initiate prolonged glucocorticoid therapy at a dosage ≥ 15 mg/day for the treatment of an inflammatory rheumatic disease. * initial treatment or relapse. * previsional treatment duration \> 3 months. exclusion criteria: * unable to consent. * previous corticosteroid therapy in the last 3 months at a significant dosage (\> 5 mg per day).
follow-up of endometrial cancer patients

Conditions: Endometrial Cancer

Summary: the present study is conducted, to elucidate the value of follow-up examinations in endometrial cancer patients. specifically the objective is to compare hospital-based follow-up examinations with instruction in self-referral in stage i endometrial cancer patients. the investigators hypothesize that the intervention, instruction in self-referral, will: * reduce fear of recurrence * improve quality of life * improve cost-utility * not affect disease-free survival.


Eligibility criteria:
inclusion criteria: * diagnosed with stage i endometrial cancer exclusion criteria: * dementia or other mental/cognitive impairment * illiterate in danish * treated with adjuvant chemo- and/or radiotherapy * high risk histology * grade 3 * follow-up for other gynecologic malignancy

Keywords: endometrial cancer follow-up examination
insertion technique in large volume paracentesis

Conditions: Cirrhosis

Summary: the purpose of this study is to compare two different methods that are used for inserting the needle during paracentesis. one method is called the "coaxial insertion technique" and the other is called the "z-tract technique". researchers would like to see which method is better and leads to less problems like oozing from the needle insertion site and pain during the procedure. both methods are approved and currently used methods for doing a paracentesis at the university of virginia. which method is used generally depends on physician preference. there have been no studies done to date that compare these two methods for needle insertion.


Eligibility criteria:
inclusion criteria: * age 18 years and older * agreement to participate * patients with cirrhosis (confirmed by liver biopsy or clinically diagnosed) and ascites * patients presenting to uva digestive health clinic for a scheduled therapeutic paracentesis who do not have any contraindications to the procedure * ability to be reliably contacted by phone 24 hours following paracentesis exclusion criteria: * prisoners * non-english speaking * paracentesis with less than 5 liters of ascitic fluid removed. (if this occurs, the specific subject encounter will be removed from the study but the subject may be included if at their next regularly scheduled paracentesis 5 liters or greater of ascitic fluid is removed.)

Keywords: paracentesis ascites
effects of diet-induced weight loss in obese men

Conditions: Sexual Dysfunction; Endothelial Dysfunction; Quality of Life; Inflammation

Summary: this study aims to compare the efficacy of a partial meal replacement diet with a conventional diet, for inducing weight loss and improving metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary tract symptoms (luts), and quality of life in obese men.

this study aims to compare the efficacy of a partial meal replacement diet with a conventional diet, for inducing weight loss, and improving metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary tract symptoms (luts), and quality of life in obese men. men aged 30-65 years, with body mass index (bmi) ≥ 27.5 kg/m2, will be recruited from the community in singapore. the study will be conducted at changi general hospital by trained medical investigators, dieticians and sports trainers. at baseline and 12 weeks, fasting glucose and lipids, insulin, testosterone, sex-hormone binding globulin, serum c-reactive protein and interleukin-6 are measured, endothelial function is measured by the non-invasive endopat method, and validated questionnaires administered to assess changes in erectile function, sexual desire, luts and quality of life

Eligibility criteria:
inclusion criteria: * male, aged 30-65 years * body mass index (bmi) \>/= 27.5 kg/m2 * waist circumference (wc) \>/= 90 cm exclusion criteria: * pituitary disease or cranial radiotherapy * previous or current androgen replacement or deprivation therapy * current treatment for sexual problems or luts * glomerular filtration rate \< 60 ml/min * liver disease * alcohol intake exceeding 500 g/week in the previous 12 months * use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors

Keywords: obesity men sexual function urinary tract symptoms endothelial function inflammation quality of life