Kornimate/medical-research-clean huggingface dataset:
documenting toothbrushing experiences of caregivers who care for children with autism spectrum disorders

Conditions: ASD I; ASD2

Summary: the objective of this study is to examine caregiver reactions to the use of the hum by colgate smart kids toothbrush and associated app by children with autism spectrum disorder (asd).

this is a single-center, pretest-posttest, non-randomized, clinical study involving interviews with caregivers prior to utilization of the research toothbrush and after 4 weeks of product use by the child. all participants enrolled will be children ages 5-12 years and their primary caregivers. participants will be asked to utilize a hum by colgate smart kids toothbrush (manual or battery-powered) for four weeks. to assure that subjects are comfortable with the oral care regime proposed, toothbrushes will be distributed based on the subject's previous oral hygiene habits. children who are currently using manual brushes will receive the hum by colgate smart manual kids toothbrush, likewise, children who are used to battery-powered toothbrushes will receive the hum by colgate smart kids battery-powered toothbrush. all the participants will be offered the electric toothbrush and will have a chance to try it during the first visit.

Eligibility criteria:
inclusion criteria: 1. signed informed consent form by the child's legal guardian on behalf of the child and from the primary (responsible for child's oral healthcare) caregiver. 2. caregiver must be able to observe the child using the hum by colgate smart manual kids toothbrush and app twice a day. 3. caregivers must have a child between the ages of 5-12 years old, who is willing to participate. 4. child must be reported in good general health and good oral health based on the opinion of the study investigator. 5. caregiver and child must be available for the duration of the study. 6. caregiver must have access to apple iphone (newer than 8) or ipad (newer than 5th generation) or android users (running android 6.0 and up) with access to an internet connection. 7. caregiver must be willing to comply with the study protocol. 8. caregiver must be willing to download and use app associated with the connected brush. 9. caregiver must be willing to be audiotaped during key informant interview sessions. 10. english fluency for the child's legal guardian/caregiver. 11. caregiver must be willing to have a shared brushing experience between themselves and the child. 12. caregiver's child must be diagnosed with asd level i or asd level ii . 1. asd level i: requiring support 2. asd level ii: requiring substantial support exclusion criteria: 1. child undergoing active orthodontic treatment with fixed appliances. 2. child has obvious signs of oral disease, severe dental caries, or pain as determined by the investigator's judgment. 3. concurrent participation by child in another clinical study. 4. child's behavior precludes participation in the study at the investigator's discretion. 5. current or previous use of the hum by colgate smart kids toothbrush by the child.

Keywords: autism spectrum disorder asd smart toothbrush caregiver experience
real-world outcome of adalimumab on rheumatoid arthritis patients in china

Conditions: Rheumatoid Arthritis

Summary: the objective of this study was to assess the effectiveness of adalimumab on health and disability outcomes in participants with rheumatoid arthritis (ra) in china.

this was a prospective, multicenter, observational study to assess the effectiveness of adalimumab on health-related quality of life (qol) and work productivity in participants with rheumatoid arthritis (ra) in routine clinical practice in china. the decision to prescribe adalimumab for ra was based on clinical practice criteria without taking participation in this study into account. participants were included in the study after a physician's decision of initiating adalimumab treatment. participants were followed for 24 weeks, with scheduled study visits at baseline, week 12 and week 24.

Eligibility criteria:
inclusion criteria: * participant had a diagnosis of rheumatoid arthritis (ra) as defined by the 1987 revised american college of rheumatology (acr) classification criteria and/or the acr/the european league against rheumatism (eular) 2010 classification criteria (any duration since diagnosis) * participants with moderate to severe ra defined as a disease activity score in 28 joints (das28) erythrocyte sedimentation rate (esr) or das28 c-reactive protein (crp) score \>3.2 * biologically treatment naïve and initiated adalimumab at baseline visit, as per standard daily clinical practice * availability of clinical data of the previous 12 weeks prior to baseline * ability to self-complete participant questionnaires. * participants had signed the authorization (or informed consent where applicable) to disclose and use personal health information after having been prescribed adalimumab exclusion criteria: * participants who were pregnant or breastfeeding at enrollment or wished to become pregnant in the next 24 weeks. * participation in any ra-related clinical trial at the time of enrollment, at baseline, or at any point during the past 24 weeks prior to baseline * participants, who in the clinician's view, may not have been able to accurately report their quality of life (qol) or prior resource utilization * participants, who in the clinician's view, may not have been able to adhere to adalimumab therapy over 24 weeks

Keywords: quality of life (qol) rheumatoid arthritis (ra) work productivity adalimumab
nurturing needs study: parenting food motivated children

Conditions: Parenting; Eating Behavior; Diet, Healthy; Pediatric Obesity

Summary: high food motivation among children is trait-like and increases risks of unhealthy dietary intake and obesity. scientific knowledge of how parenting can best support healthy eating habits and growth among children who are predisposed to overeating is surprisingly limited. this investigation will identify supportive food parenting approaches for obesity prevention that address the needs of highly food motivated children.

high levels of food motivation among young children are heritable, track over time, and associated with elevated risks of unhealthy eating and obesity. despite significant growth of family-based obesity prevention efforts, the evidence base is remarkably scant on parenting highly food motivated children to prevent obesity and poor dietary outcomes. the goal of this investigation is to generate a robust basic science evidence for parenting highly food motivated children to prevent excessive dietary intakes and body mass index (bmi) gains during the preschool years. using a prospective cohort design, this investigation follow 300 caregiver/child dyads over 18 months as children transition from preschool to elementary school, when significant numbers of children begin to experience problems of poor diet quality and obesity. children with varying food motivation will be recruited to understand whether highly food motivated children have different needs than other children. a multi-method approach will use state-of-the-art measures, including ecological momentary assessment, to comprehensively investigate the amount, types, and consistency of food parenting practices (i.e., specific, goal-oriented behaviors) needed to prevent food motivated behaviors, excessive dietary intake, and bmi gains in children. specifically, the role of structure (i.e., theoretically supportive) and its differentiation from more coercive types of food parenting control will be comprehensively characterized.

Eligibility criteria:
inclusion criteria: 1. child ages 4 or 5 years at baseline; 2. parent/ primary caregiver with legal representation (having 50% or more custody of child); 3. parent/primary caregiver reporting primary responsibility for child feeding outside of childcare (being with child when they are eating at least two times daily); 4. caregiver with a cell phone that can be used to send and receive text messages. if there is more than one age-eligible child in the family, we will ask the caregiver to pick the index child. exclusion criteria: 1. parent/primary caregiver \<18 years of age; 2. child history of major food allergies (e.g., peanuts); 3. child medication use (e.g., insulin), developmental disability (e.g., autism) or medical condition(s) (e.g., diabetes) known to affect food intake and growth; 4. foster child.
treatment of male pattern baldness with botulinum toxin

Conditions: Male Pattern Baldness

Summary: this proof of concept study seeks to demonstrate that botulinum toxin injections are a safe and effective method for treating this form of hair loss.


Eligibility criteria:
inclusion criteria: * male pattern baldness * norwood ii-vi exclusion criteria: * treatment with botulinum toxins or other hair growth interventions with past year

Keywords: male pattern baldness androgenetic alopecia hair loss
ringer's lactate versus normal saline in caesarean section

Conditions: Normal Anion Gap Metabolic Acidosis

Summary: the objective of this study is to compare the effect on mean maternal and neonatal ph, and 24-hour postoperative morbidity, following intraoperative infusion of ringer's lactated versus normal saline in caesarean section at mulago hospital. the null hypothesis is that intraoperative infusion of ringer's lactate in caesarean section at mulago hospital will not result in 30% less mean maternal and neonatal ph change than intraoperative infusion of normal saline.

fluid therapy in caesarean section surgery in mulago hospital is done mostly with 0.9% normal saline (ns). several studies have highlighted the complications associated with large infusion of normal saline. few studies have compared the effects of an alternative crystalloid, ringer's lactate (rl), on perinatal ph and postoperative morbidity in caesarean section surgery. this trial will be performed in mulago hospital labour ward theatre on parturients who consent and are scheduled for either elective or emergency caesarean section under spinal anaesthesia from september 2011 to may 2012. study fluid will be administered intraoperatively only. preoperative and postoperative venous blood samples will be drawn for venous blood gases, serum urea and creatinine. placental umbilical arterial cord blood will also be drawn for neonatal arterial blood gases. mothers will be followed up for 24 hours for incidence of postoperative morbidity.

Eligibility criteria:
inclusion criteria: * all parturients who consent for the study. * up to american society of anesthesiology (asa) class іі/e. exclusion criteria: * failed spinal anaesthesia that has to be converted to general anaesthesia.

Keywords: hyperchloraemic metabolic acidosis neonatal acidosis neonatal hyperchloraemia base excess metabolic acidosis caesarean section normal saline ringer's lactate postoperative morbidity
safety and efficacy study of avb-s6-500 (batiraxcept) in patients with advanced or metastatic clear cell renal cell carcinoma

Conditions: Clear Cell Renal Cell Carcinoma

Summary: this is a phase 1b/2 study of avb-s6-500 designed to evaluate the safety and efficacy of avb-s6-500 in combination with cabozantinib, avb-s6-500 in combination with cabozantinib and nivolumab and avb-s6-500 monotherapy in subjects with advanced or metastatic clear cell renal cell carcinoma (ccrcc). the phase 1b portion of the study is open label and patients with advanced ccrcc who had progressed on or after at least one prior line of treatment will receive avb-s6-500 + cabozantinib. two dose levels will be evaluated. the phase 2 portion of the study is open-label 3-part study to evaluate efficacy and tolerability of avb-s6-500 + cabozantinib, avb-s6-500 + cabozantinib + nivolumab, and avb-s6-500 alone.


Eligibility criteria:
inclusion criteria: * age 18 years or older * histologically confirmed advanced or metastatic clear cell renal cell carcinoma confirmed by imaging. phase 1b and phase 2 part a: has progressed on/after at least one front-line of treatment; phase 2 part b: no prior systemic treatment; phase 2 part c: not amenable to curative intent therapy. * must have radiologic imaging with a computed tomography (ct) scan or magnetic resonance imaging (mri) within 28 days of enrollment * must have at least one measurable lesion according to recist 1.1 * ecog performance status of 0-1 * adequate bone marrow, liver and kidney function * life expectancy of \>12 weeks * at least 28 days between termination of prior major surgery or anticancer therapy or 14 days from last radiation therapy and administration of avb-s6-500 exclusion criteria: * received prior treatment with cabozantinib (phase1b and phase 2 part a) * received prior treatment with nivolumab (phase 2 part b) * concurrent anti-cancer therapy or any other interventional treatment or other interventional research trial * history of prior malignancy within the past 3 years except adequately treated basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the prostate, cervix or breast * symptomatic cns metastasis or metastases * active gi disease that would impact absorption of cabozantinib * nephrotic range proteinuria at screening * evidence of pleural effusion, ascites etc that requires therapeutic intervention within 28 days prior to avb-s6-500 administration * phase 2 part a and part b: has had a major bleed in the last 3 months, uncontrolled hypertension despite treatment with antihypertensives or is not appropriate for treatment with cabozantinib in the investigator's opinion * serious active infection requiring iv antibiotics and/or hospitalization at study entry * phase 2 part b: has active, known or suspected autoimmune disease, defined as requiring systemic treatment * active covid-19, hiv, hepatitis b or hepatitis c virus.

Keywords: clear cell renal cell carcinoma renal cell carcinoma recurrent renal cell carcinoma kidney cancer kidney neoplasms kidney diseases urologic neoplasms
calorie restriction with leucine supplementation

Conditions: Obesity; Menopause; Osteoporosis; Sarcopenia

Summary: the purpose of this study is to determine whether consuming additional leucine during calorie restriction induced weight loss has beneficial or harmful effects on multi-organ (liver, muscle, adipose tissue) insulin sensitivity, colonocyte proliferation rates, the gut microbiome, muscle mass and function, and bone mineral density in obese, postmenopausal women.


Eligibility criteria:
inclusion criteria: * obese with body mass index (bmi) between 30 and 40 kg/m2 * postmenopausal * sedentary (i.e., less than 1.5 hours of exercise per week) exclusion criteria: * individuals with diabetes and/or uncontrolled hypertension * individuals with hepatitis b and/or c * individuals who smoke * individuals with an allergy to whey protein
the effect of progressive relaxation exercise with music therapy on sleep quality and pain intensity

Conditions: Postoperative Pain; Postoperative Sleep Quality

Summary: this study was conducted to determine the effect of progressive relaxation exercises with music therapy on sleep quality and pain severity of patients hospitalized in the surgical departments of a university hospital.this single-blind, pre-test-post-test with control group design quasi-experimental study was carried out between march-july 2019. 31 patients who were hospitalized in surgical departments for at least one week and regularly performed relaxation exercises consisted of experimental group, and 31 patients who were hospitalized for at least one week but did not do relaxation exercises consisted of control group. the study data were collected by using "descriptive characteristics form", pain severity of patients was measured using "visual analogue scale", and sleep quality of patients was measured using "visual analogue sleep scale". the patients were asked to perform the exercises with music an average of 30 min before sleeping every day for a week. the observation of the nurse working in department and the patient's statement were used for control. the ethical permission and the approval of hospital management were obtained for the study. in the statistical analysis of the data, independent sample t test, one-way anova and paired sample t test were used. statistical significance level was taken as p\<.05.

inclusion criteria in the study: * agree to participate in research * staying in surgical wards for at least one week between the dates of the study * being 18 years or older * not regularly practicing relaxation exercises before exclusion criteria from the study: * refusing to participate in research * being discharged before one week after admission to surgical services within the range of the study date * those who are hospitalized for more than a week due to the possibility of serious illness diagnoses that prevent patients from performing relaxation exercises * being 18 years or younger * communication problem * regularly practicing previous relaxation exercises

Eligibility criteria:
inclusion criteria: * agreeing to participate in research * lying in surgical wards for at least a week in the range of the date of the study * being 18 or older * don't practice relaxation exercises regularly before exclusion criteria: * not agreeing to participate in research * discharge before a week after admission to surgical wards within the range of the date of the study * those with more than a week's sleep due to the likelihood that patients may have received serious disease diagnoses that would put them off doing relaxation exercises * being 18 and under * don't be a communication problem * practice relaxation exercises regularly before

Keywords: pain postoperative sleep progressive relaxation exercise music
heart failure monitoring with a portable ultrasound device with artificial intelligence assisted tools: a multi-phase observational feasibility study

Conditions: Congestive Heart Failure

Summary: the primary objective of this study is to evaluate the feasibility of a novel app to facilitate heart failure patients to acquire lung ultrasound images and evaluate the quality of those images to expert scans, and to evaluate for relationships between the ultrasound data and pulmonary pressure data from the abbott cardiomems system.

feasibility study to compare an investigational artificial intelligence (ai) auto b-line tool measurement on lung ultrasound (us) images acquired with an ai assisted guidance tool by novice ultrasound clinicians and heart failure (hf) patients, to standard of care heart failure monitoring of pulmonary artery pressure measured by the abbott cardiomems system.

Eligibility criteria:
inclusion criteria: 1. documented diagnosis of heart failure at least three months prior to the date of consent 2. hf currently managed with the abbott cardiomems device 3. able to read and write in english. 4. at least 18 years of age or older on the date of consent. 5. willing and able to provide written consent to participation 6. expressed willingness to capture ai assisted us recordings immediately before or after taking their cardiomems measurements 7. access to wifi or cellular data connection at home 8. in the opinion of the investigator or delegate the subject, must be capable of complying with study procedures. exclusion criteria: 1. previous experience using an ultrasound device on themselves or others 2. women who are pregnant or plan to become pregnant during the study

Keywords: cardiomems iq+ home chf b-lines
the efficacy of hyperemesis gravidarum on macular thickness, corneal thickness and intraocular pressure in pregnancy

Conditions: Corneal Dystrophy; Macular Dystrophy; Hyperemesis Gravidarum - Severe

Summary: aim physiological changes in intraocular pressure as well as in the cornea and macula may occur during pregnancy. in the literature, there are limited data on ocular findings in hyperemesis gravidarum. therefore, we have decided to investigate the effect of hyperemesis gravidarum on macular thickness, corneal thickness and intraocular pressure (iop).

a total of 110 people, 55 of whom were diagnosed with hyperemesis gravidarum and 55 of whom were in the control group, were included in the study. the inclusion criteria for the study were as follows: first trimester (8-14 weeks of gestation) pregnancy with positive fetal heartbeat and no history of systemic disease; no continuous use of medication; diagnosis of hyperemesis gravidarum (ketonuria and weight \> 3 kg or 5% of the body) and the occurrence of less than three vomiting attacks per day with loss of weight; body mass index (bmi) within normal limits; being between the ages of 18 and 40; not drinking alcohol or smoking. a total of 94 patients, 40 of whom were diagnosed with hyperemesis gravidarum and 54 healthy pregnant women, were divided into two groups by recording their age, bmi, laboratory and eye findings.

Eligibility criteria:
inclusion criteria: * inclusion criteria for the study; * first trimester (8-14 weeks of gestation) pregnancy with positive fetal heartbeat and no history of systemic disease , * no history of continuous drug use, * diagnosis of hyperemesis gravidarum (ketonuria and weight \>3 kg or 5% of the body) the occurrence of \>3 vomiting attacks per day with loss of weight, * body mass index (bmi) within normal limits, * being between the ages of 18-40 , * not drinking alcohol or smoking, * not using any vitamins or supplements use during the study exclusion criteria: * any patient who did not meet the inclusion criteria was excluded from the study. * patients who participated in the study but later gave up
concomitant infection of intestinal parasites and helicobacter pylori

Conditions: Dyspepsia Abdominal Burning Pain Diarrhea Dysentery

Summary: intestinal parasitic infections such as giardia lamblia, entamoeba histolyica and enterobius vermicularis are among the most common infections worldwide.so parasitic infections are considered one of the major health problems in the world especially in developing countries. helicobacter pylori is a gram-negative,helical-shaped,motile bacillus bacterium,which colonizes the gastric mucosa. h.pylori bacterium secretes urease,a special enzyme that converts urea to ammonia. ammonia reduces the stomach's acidity .this risk factor allows pathogenic intestinal protozoa such as g.lamblia to take the opportunity to cross through the stomach's increased ph and cause disease.


Eligibility criteria:
inclusion criteria: * patients complaining of dyspepsia , abdominal burning pain,diarrhea,dysentery,of persons of any age or sex group. exclusion criteria: * patients taking antibiotics within the previous four weeks, proton pump inhibitors within the previous two weeks, or anti-parasitic drugs within the previous two weeks.

Keywords: helicobacter pylori intestinal parasites