Kornimate/medical-research-clean huggingface dataset:
predictive biomarkers of secondary aggravation in covid-19 suspect patient

Conditions: Infection Viral; Coronavirus; COVID-19

Summary: there is no predictive tool for patients admitted to the emergency department with a suspicion of covid-19 that will worsen secondarily and require a heavy lifting. in a context of saturation of the healthcare system by the pandemic at covid-19,it is essential to identify specific, accessible prognostic markers via minimally invasive sampling with low risk of infection for personnel caregiver, for optimal allocation of resuscitation resources. this study proposes to evaluate the biological markers of routine care known to be associated with resuscitation admission in relation to hospitalization on conventional service for the prediction of worsening of patients admitted to the emergencies for covid-19.


Eligibility criteria:
inclusion criteria: * clinical criteria for suspicion of covid-19 in an epidemic period * consultation in the emergency departement * non-opposition agree exclusion criteria: * impairment related to another identified cause than covid-19, in particular a rapid diagnostic test flu-positive * severe patient from the outset with transfer to intensive care within 12 hours of admission to the emergency department * no social security coverage (beneficiary or entitled person) * poor understanding of french * refusal to participate

Keywords: infection viral biological risk factor coronavirus covid-19
evaluation of new diagnostic indicator of subclinical hypercortisolism

Conditions: Adrenal Incidentaloma; Subclinical Hypercortisolism

Summary: the purpose of this study is to evaluate the serum dehydroepiandrosterone sulfate in subclinical hypercortisolism

in the past few years, with the widespread use of chest and abdominal imaging, the prevalence of adrenal incidentaloma (ais) has been increasing and now approaches the 8.7% incidence reported in autopsy series. subclinical hypercortisolism (sh) is noted in up to 30% of patients with adrenal incidentalomas. several groups have reported adverse clinical sequelae in individuals with sh, with recent studies highlighting an increase in cardiovascular morbidity and mortality compared to the general population. accurate exclusion or confirmation of a diagnosis of sh is therefore a key step in the investigation and management of patients with ais. suppressed adrenocorticotropic hormone (acth) and low dehydroepiandrosterone sulfate (dheas) levels are frequently found in sh patients. present study added new evidence for the limitations of acth and confirmed the usefulness of dheas for the detection of sh especially with unsuppressed acth in ai patients. on one hand, in the cross-sectional study, biometric measurements and sex hormones (including dheas, 24h-ufc, acth and cortisol) are analysed to explore the differences among sh patients, and nonfunctional adrenal adenoma patients. one the other hand, in the longitudinal study, changes in dheas, acth and cortisol in sh with surgical management and sh with conservative management both at baseline and different follow-up months after their different treatment management are collected to explore the changes of dheas and acth of sh patients.

Eligibility criteria:
inclusion criteria: * patients with adrenal accidental tumor (diameter \> 1cm) found by physical examination or imaging examination due to non-adrenal diseases exclusion criteria: * concomitant use of drugs influencing glucocorticoid metabolism or secretion * major psychiatric illness or history of excess alcohol intake * overt clinical features of hypercortisolism * clinical and endocrine function evaluation (surgery patients at the same time reference to postoperative pathology) revealed primary aldosteronism, pheochromocytoma, adrenocortical carcinoma, adrenal metastasis of cancer, myelolipoma; oncocytoma, congenital adrenal cortex hyperplasia and ganglion cells neuroma/paraganglioma, schwannoma, adrenal hematoma and uncertain diagnosis) * non-adenoma lesions such as cysts and hemorrhage * the pregnancy * patients with severe underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamus-pituitary-adrenal axis (hpa axis)

Keywords: serum dehydroepiandrosterone sulfate adrenocorticotropic hormone surgical management conservative management
sensation after nipple sparing mastectomy and breast reconstruction with or without neurotized free tissue transfer

Conditions: Mastectomy; Breast Reconstruction

Summary: tissue expander/implant reconstruction: the purpose of this study is to determine how and when nerve sensation to the breast skin returns after mastectomy. autologous tissue reconstruction: the purpose of this study is to determine whether the tissue being used to reconstruct your breast can provide sensation by using your own nerves. typically all sensation is lost immediately after this type of surgery and returns to varying degrees. we are hoping to demonstrate that by connecting the two nerves (one from abdomen and one from the chest wall) together, we can attain meaningful sensation in the transferred tissues thereby improving your quality of life following surgery.

to determine the timing and distribution of sensation recovery of breast after mastectomy and breast reconstruction, both with autologous and implant-based reconstruction. also, to determine the role of innervated free tissue transfer in breast reconstruction. specific aims 1. determine the timing and degree of return of breast in women who underwent mastectomy with autologous tissue or with implant based reconstruction. 2. determine sensation following neurotized free flap reconstruction 3. determine whether neurotization has an impact on quality of life measures post operatively study design patients will be enrolled prospectively in this data collection study in which they will receive the standard of care for breast cancer resection and oncologically safe and accepted means of breast reconstruction with tissue expander and/or prosthetic implants. patients will receive additional, non-invasive sensory testing, performed at standard follow up intervals in clinic by their reconstructive team. all patients participating in the study will be consented for enrollment at the pre-operative visit by either the surgeon or physician assistant. as this is a prospective study, all women fitting inclusion criteria over a 6-month minimal, but projected goal 12-month period will be included.

Eligibility criteria:
inclusion criteria: * patients undergoing unilateral or bilateral skin sparing mastectomy for breast cancer * patient must have one of the following reconstructions in planned: * immediate tissue expander placement * immediate implant placement * immediate autologous breast reconstruction * all patients participating in the study must be willing to be consented for enrollment at the pre-operative visit. exclusion criteria: * pre-operative radiation therapy * any pre-excising * patients with absent or prior damaged nipple areola-complex (nac) on the "non-surgical breast"

Keywords: breast cancer sensation recovery neurotization
neurodevelopment outcomes after pediatric dental caries treatment under general anaesthesia

Conditions: Anesthesia

Summary: the purpose of this study is to investigate whether early expose to general anaesthesia will influence neurodevelopment.

participants, according to the state of illness and clinical requirements, assigned to receive dental caries treatment with or without general anesthesia. during the follow-up, various of neurodevelopment assessment will be done at specific timepoint to investigate whether general anaesthesia will influence neurodevelopment.

Eligibility criteria:
inclusion criteria: * gestational age\>=36 weeks * american society of anesthesiologists（asa） physical status ⅰ or ⅱ，with very limited systemic disease. * age\<=6 yr exclusion criteria: * did not provide research authorization； * unable to contact or inconvenient for follow-up; * hypersensitive to general anesthesia drug; * previous exposure to general anesthesia in utero; * previous exposure to general anesthesia as a neonate * previous exposure to psychotropic medication; * complications at birth such as low weigh, hypoxia, or cerebral edema; * any other known diseases may influence the neurodevelopment

Keywords: anesthesia neurodevelopment dental caries
exercise intervention in liver transplant patients

Conditions: End Stage Liver Disease; Sarcopenia; Liver Cirrhoses

Summary: the purpose of this study is to learn more about the effects of exercise on functional status and outcomes on patients with end-stage liver disease on the liver transplant waiting list and who have undergone liver transplantation.

this study aims to evaluate the effects of a home-based exercise intervention on outcomes in liver transplant candidates and recipients. this home-based intervention consists of a 30-minute exercise session available on digital video disc or on the internet. this intervention was originally developed to improve functional status in community-dwelling older adults and therefore, has been designed to maximize the safety for even the most frail individuals. subjects enrolled in this study will be randomized to one of two arms: (a) the exercise intervention arm in which the subjects will be asked perform this exercise session three to four times per week or (b) the standard-of-care arm in which the patient will be encouraged to exercise by their transplant clinician at every clinic visit. subjects in the exercise intervention arm will undergo this intervention for 6 months. all subjects will be followed for up to two years from the time of enrollment to ascertain outcomes.

Eligibility criteria:
inclusion criteria: * adult (\>=18 years of age) * listed for liver transplantation or post-liver transplantation * english speaking exclusion criteria: * contraindications to weight-bearing exercise * non-english speaking * requires an assistive device for ambulation * active hepatic encephalopathy at the time of baseline assessment for enrollment in the study

Keywords: liver transplantation
vaginal repair of post cesarean istmocele

Conditions: Gynecologic Disease

Summary: 20 women with symptomatic postcesarean isthmocele (niche) will be recruited evaluated and subjected to a vaginal repair of the defect, results will be analyzed.

methods: * subjects: women in childbearing period with abnormal uterine bleeding or infertility attributed to post cesarean isthmocele (sample size to be calculated) * preoperative evaluation: transvaginal ultrasound to exclude any other uterine or adnexal pathology, and to measure: 1. distance from the external cervical os to the lower end of the isthmocele (a) 2. distance from the external cervical os to the upper end of the isthmocele(b) 3. length of the isthmocele (b-a) 4. residual myometrial thickness (the least) of the isthmocele. * routine preoperative workup. * the technique: * postmenstrual * spinal anesthesia * sterilization of the perineum and vagina * cervical dilation up to 8mm using hegar's dilators * marking the previously measured points a \& b * making 2 transverse incisions, one 5mm below a and the other 5 mm above b. * the rectangular area between the 2 incisions is excised while the hegar's dilator number 8 in in situ. * hemostasis is performed using diathermy. * the upper and lower edges of the incision are approximated using number 2/0 vicryl on cutting needle taking 3 to 4 interrupted sutures * the patients with uneventful postoperative course are discharged from hospital after 8 hours with doxycycline 100 mg bid for 5 days. * sexual intercourse is avoided for 4 weeks postoperative * postoperative transvaginal ultrasound follow up; at 1 month postoperative. * data will be statistically analyzed and results will be tabulated.

Eligibility criteria:
inclusion criteria: * women diagnosed with symptomatic post cesarean isthmocele. * should present with abnormal uterine bleeding . exclusion criteria: * presence of any other uterine pathology, * presence of adnexal pathology, * presence of malignancies, * presence of pregnancy, * presence of infection in the lower genital tract , * general cause of bleeding * women not accepting the procedure, * women not consented
e-health-supported diagnostic and intervention in preterm born children and their families

Conditions: Preterm Birth

Summary: the app-based diagnostic and support approach with a focus on mental and somatic symptoms is intended to strengthen the resilience of premature born children and families and to identify risk and resilience factors.the overall objective of the study is to improve the post-inpatient care of families with premature born children. the procedure is evaluated by a two-arm design with an experimental group and a tau group.

the project aims to conduct a longitudinal study of premature babies and their parents from the time of hospital discharge in order to identify predictive factors for their psychological and physical outcomes and to provide individualized interdisciplinary diagnostic and treatment. the project helps to identify risk and protective factors and also takes a closer look at the interplay between the mind and body. this care approach is supported by an app that records symptoms and needs and also allows contact with the study team. the app also provides psychoeducational materials. the study was developed in collaboration with affected families and experts from the aftercare team. the concept will be evaluated by comparing the treatment group with a tau group and by conducting measurements after hospital discharge, after 4 months, and again after 7 months, as well as through focus groups with study participants.

Eligibility criteria:
inclusion criteria: * premature babies born at the ukt, * gestational age 28-34 weeks, * mother: age ≥ 18 years, * agreement to participate in this study and signing of a consent form, * sufficient knowledge of german, * internet access exclusion criteria: * premature babies \ 34th week of pregnancy, * at least one of the children has serious diseases of the nervous system or obvious symptoms of a nervous disease, * at least one of the children has serious congenital diseases or suffers from malformations, * mother: lack of access to a smartphone/tablet, * no internet access, * insufficient knowledge of german

Keywords: preterm birth e-health risk factors protective factors prevention
pituitary tumor surveillance: pathogenic correlation

Conditions: Pituitary Tumor

Summary: the purpose of this study is to observe predictors of pituitary tumor recurrence and markers of persistent disease activity in patients harboring pituitary mass lesions of all types.

the purpose of this study is to observe predictors of pituitary tumor recurrence and markers of persistent disease activity through computerized collection of comprehensive demographic, therapeutic, pathologic and outcome information on patients harboring pituitary mass lesions of all types.

Eligibility criteria:
inclusion criteria: * patients with confirmed pituitary disease exclusion criteria: * patients who do not have confirmed pituitary disease

Keywords: pituitary tumor recurrence
bougie versus endotracheal tube alone on first-attempt intubation success in prehospital emergency intubation (beta trial)

Conditions: Acute Respiratory Failure Requiring Intubation

Summary: emergency intubation is routinely performed in the prehospital setting. airway management in the prehospital setting has substantial challenges, such as hostile environment or lack of technical support in case of first attempt intubation failure, and inherent risk of complications, such as hypoxemia, aspiration or oesophageal intubation. this risk is higher when several attempts are needed to succeed endotracheal intubation. thus, a successful first attempt intubation is highly desirable to avoid adverse intubation-related events. noteworthy, prehospital emergency intubation is associated with a lower rate of first attempt intubation success when compared to emergency intubation in the emergency department (ed). research is needed to overcome the specific challenges of airway management in the prehospital setting, and to improve the safety and efficiency of prehospital emergency intubation. literature reports that the use of assistive devices such as bougie may increase the rate of first-attempt intubation success in the ed. to date, no randomized trial has ever studied this device in the prehospital setting. thus, the aim of the beta trial is to compare first attempt intubation success facilitated by the bougie versus the endotracheal tube alone in the prehospital setting.


Eligibility criteria:
inclusion criteria: * managed by a physician staffed mobile intensive care unit (micu). * with an indication of emergency prehospital endotracheal intubation. exclusion criteria: * pregnant women * patients with a "not to be resuscitated" indication. * patients with predictors of difficult intubation (that can be collected in the prehospital setting, including previous history of face, neck, throat surgery or pathology, limited mandibular protrusion, cervical spine trauma, facial trauma, ear-nose-throat malignancy, head or neck burns, history of previous difficult airways) for whom the use of a bougie is indicated on first intubation attempt. * patients under guardianship, trusteeship or safeguard of justice and patients with no health insurance.

Keywords: bougie intubation acute respiratory failure airway critical care
educational video's impact on knowledge regarding cervical cancer screening

Conditions: Human Papilloma Virus; Cervical Dysplasia

Summary: the researchers will be conducting a prospective randomized trial where the researchers will be introducing an educational video to see whether there is an increase in knowledge scores surrounding cervical cancer, cervical cancer screening, and prevention with hpv vaccinations.

the researchers are conducting a single-blinded randomized controlled trial. all patients who meet exclusion criteria will be recruited at the time of their visit where a pap smear will be collected at an ob/gyn clinic. if patients agree to participate in the study, they will be randomized into one of two arms. a control arm or an interventional arm. the control arm just includes physician counseling regarding cervical cancer screening/prevention, while the interventional arm includes patient's watching a video on cervical cancer screening/prevention as well as physician counseling. patient will be administered a survey before and after to assess knowledge and satisfaction scores.

Eligibility criteria:
inclusion criteria: * female patient * hispanic patients * between age 21-65 y/o * receiving pap smear during clinic appointment exclusion criteria: * non-female patients * non-hispanic patients * age less than 21 * age greater than 65 * not receiving pap smear

Keywords: cervical cancer screening pap smear hpv vaccination
phrenic nerve stimulation-induced lung reaeration trial

Conditions: Acute Respiratory Distress Syndrome; Ventilation Therapy; Complications

Summary: the lungpacer protect diaphragm pacing therapy system (dpts) is a temporary, percutaneously-placed, transvenous, phrenic nerve-stimulating device intended to stimulate the diaphragm to preserve and improve inspiratory muscle strength in mechanically ventilated patients. the purpose of the protect dpts is to improve gas exchange, regional lung ventilation, and hemodynamics, and decrease atelectasis in patients presenting with acute respiratory distress syndrome (ards).

the pirat clinical study is intended to assess the feasibility, safety and effectiveness of transvenous phrenic-nerve-stimulating diaphragm pacing on clinical outcomes in mechanically ventilated patients. by delivering electrical stimulation to the phrenic nerves, which in turn causes the diaphragm muscle to contract, the protect dpts is intended to protect the diaphragm from atrophy and preserve lung mechanics to reduce lung inflammation and injury associated with short-term mechanical ventilation. sustained lung and diaphragm health during early mechanical ventilation is expected to reduce the risk of comorbidities, improve clinical outcomes such as weaning success, and thereby reduce the number of patients who require prolonged mechanical ventilation.

Eligibility criteria:
inclusion criteria: * are 18 years or older * have been mechanically ventilated due to moderate ards for 48-120h * have a pao2/fio2 ratio \ 100 at the time of screening with peep ≥ 5 cmh2o * are expected to remain on mechanical ventilation ≥ 48 hours * are under continuous sedation with richmond agitation sedation scale (rass) ≤ -3 exclusion criteria: * septic shock with hemodynamic instability (norepinephrine or epinephrine \< 0.5 gamma/kg/min) * catheter access to left subclavian vein deemed impossible * use of neuromuscular blocking agents within last 12 hours * bacteremia within the last 48 hours or uncontrolled source of infection * currently on ecmo * enrolled in any other study of an investigational drug or device, which may affect the outcomes of the current study * pre-existing neurological, neuromuscular or muscular disorder that could affect the respiratory muscles * bmi \>45 kg/m2 * known or suspected phrenic nerve paralysis * any electrical device (implanted or external) that may be prone to interaction with or interference from the lungpacer protect dpts, including neurological pacing/stimulator devices and cardiac pacemakers and defibrillators * no affiliation to the french health insurance system * under curatorship * imprisoned * known or suspected to be pregnant or lactating
tumor collection from routine nephrectomy for subjects with advanced stage rcc

Conditions: Kidney Cancer; Renal Cell Carcinoma; Advanced Renal Cell Carcinoma

Summary: standard treatment for kidney cancer is to remove the tumors from the body with surgery. the purpose of this clinical trial is to collect, preserve, and store excess kidney cancer tumor specimens that would normally be discarded after surgery.

the purpose of this non-treatment, non-interventional protocol is to collect, preserve, and store excess tumor specimens, which would otherwise be discarded, following routine nephrectomy for subjects with advanced renal cell carcinoma (rcc). the collected tumor specimen will be preserved under current good manufacturing practice conditions and will not be used for any other research or therapeutic purpose without a separate consent from the subject, specific to the intended use on a separate institutional review board or institutional ethics committee approved argos sponsored study. following routine nephrectomy (partial or cytoreductive) as indicated for subjects with advanced rcc, small samples of the excised tumor will be sectioned and placed into an rna preservative solution as supplied by the sponsor. after collection, this preserved tumor specimen will be shipped to a repository operating under current good manufacturing practice conditions. the tumor specimen will be stored for no longer than five years unless subsequent consent is obtained for extended storage or other use.

Eligibility criteria:
inclusion criteria: * 1. age ≥ 18 years * 2. diagnosis or clinical signs of advanced rcc (stage iii or iv rcc; refer to appendix a) * 3. scheduled for cytoreductive or partial (unilateral or bilateral) nephrectomy * 4. signed and dated informed consent document indicating that the subject (or legally acceptable representative) has been informed of all pertinent aspects of tumor specimen collection prior to enrollment exclusion criteria: * 1. evidence of brain metastases prior to nephrectomy * 2. requirement for systemic chronic immunosuppressive drugs or systemic chronic corticosteroids, for active autoimmune disorder(s) or other conditions (e.g.: rheumatoid arthritis, systemic lupus erythematous, multiple sclerosis, organ transplant recipient, etc.) * 3. history of hiv infection, or history of chronic infection with hepatitis b or hepatitis c