Kornimate/medical-research-clean huggingface dataset:
predict + protect study: exploring the effectiveness of a predictive health education intervention on the adoption of protective behaviors related to ili

Conditions: Influenza; Influenza A; Influenza B; COVID-19; Respiratory Syncytial Virus (RSV)

Summary: the goal of this prospective, digital randomized controlled trial is to evaluate the effectiveness of a predictive ili detection algorithm and associated alerts during influenza season for adults living in the contigent united states. the main study objectives are to assess the effectiveness of predictive ili detection algorithm and associated alerts on protective behaviors related to ili and assess the accuracy of a predictive ili detection algorithm using participant self-reported ili symptoms and diagnosis.


Eligibility criteria:
inclusion criteria: * member of the evidation platform * 18 years or older * lives in the u.s. * currently owns and uses a consumer wearable activity tracker (apple watch, garmin, or fitbit) linked to their evidation account * meets data density requirements for wearable data: steps and heart rate data present for 15% of the last 60 days (or no fewer than 2 total days for evidation accounts less than 60 days old) exclusion criteria: * does not have an evidation account * not 18 years or older * does not live in the u.s. * does not have an activity tracker linked to their evidation account * enrolled in an evidation supported ili monitoring and engagement program, or clinical study (e.g., flusmart)

Keywords: flu influenza rsv covid wearable
identification of surgical management of lymph node basins and surgical practice patterns among sarcoma surgeons

Conditions: Soft Tissue Sarcoma; Lymph Node Cancer

Summary: this study investigates the surgical management of lymph node basins for extremity and trunk soft tissue sarcoma (etsts) to identify and better understand the surgical practice patterns of sarcoma surgeons. etsts has been known to spread to distant locations including lymph nodes, with some subtypes of the disease spreading to lymph nodes more than others. this has led to sarcoma surgeons to treat patients differently from one another, including those with more lymph node involvement. the purpose of this study is to investigate the practice patterns of etsts surgeons.

primary objectives: i. identify the practice patterns of sarcoma surgeons with respect to management of lymph node basins for extremity and trunk soft tissue sarcomas (etsts). ii. identify when surgeons would perform sentinel lymph node biopsy and/or lymph node dissection for etsts and if management differs for high-risk subtypes of sarcoma that are more likely to have nodal metastases. iii. identify differences in practice patterns between surgical oncologists and orthopedic oncologic surgeons. outline: participants complete an online survey over 5-10 minutes asking how they would manage lymph node basins in the extremity sarcoma.

Eligibility criteria:
inclusion criteria: * currently practicing surgeons who treat etsts and are members of the society of surgical oncology and musculoskeletal tumor society exclusion criteria: none
haploidentical transplantation with early adoptive transfer of cd56+cd3- nk cells

Conditions: Acute Myeloid Leukemias; Advanced Hematological Malignancies; Indication for Allogeneic Stem Cell Transplantation; no HLA-identical Donor Available

Summary: experimental and clinical data suggest that alloreactive nk cells can reduce the risk of graft-rejection, gvhd and leukemic relapse after hla-mismatched transplantation. the effectiveness of allogeneic nk cells is a function of hla-differences between donor and recipient that give rise to nk cell clones which do not express inhibitory receptors matching for the hla molecules of the recipient. aim of the study is to evaluate cellular therapy with alloreactive, il-2 activated nk cells after transplantation of t-cell depleted stem cell grafts from one haplotype mismatched family donors in patients with hematological malignancies.


Eligibility criteria:
inclusion criteria: * patients with aml or all in first cr with the following high risk features: 1. aml with aberration del (5q) -5, del (7q) -7, t(9;22) or t(6;9), abn 3q, 9q, 11q, 20q, 21q, 17p; 2. aml with a complex caryotype; 3. secondary aml after previous chemo- or radiotherapy or mds; 4. ph-positive all * patients with aml or all after induction failure or in second cr * patients with cml in second chronic or accelerated phase * patients with malignant lymphoma and the following high risk features: 1. relapse after autologous transplantation 2. primary chemotherapy refractory disease * all patients must fulfill the following criteria: 1. lack of a suitable hla-identical family, unrelated or cord blood donor 2. no active infection, no severe impairment of cardial, pulmonary, renal and hepatic function 3. blast count in the marrow \< 30% 4. informed consent exclusion criteria: * active infection, no severe impairment of cardial, pulmonary, renal and hepatic function * blast count in the marrow \> 30% * unable or unwilling to sign and/or understand informed consent
a safety and pharmacokinetics study in participants with rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: the purpose of this study is to examine the safety and efficacy of this antibody in participants with rheumatoid arthritis. part a of the study is an initial dose escalation phase part b of the study is a randomized allocation of the entire dosing group to parallel treatment assignments


Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis * regular use of methotrexate * active rheumatoid arthritis exclusion criteria: * juvenile rheumatoid arthritis * evidence of tuberculosis * women who are pregnant or become pregnant during study, or are breast-feeding
pet-tc in thyroid evaluation

Conditions: Medullary Thyroid Carcinoma; Hyperparathyroidism; Parathyroid Carcinoma

Summary: the thyroid gland may have a diffuse or focal uptake of numerous pet/ct radiopharmaceuticals and this may be correlated with underlying benign and malignant thyroid/parathyroid pathologies. it is not clear at present if the uptake of the radiopharmaceutical alone is associated with a potential malignancy of the disease. the aim of the study is to collect evidence and consolidate the diagnostic power of pet/ct, to identify any predictive parameters that can determine whether pet positivity/negativity can in the future avoid unnecessary tests such as needle aspiration.

the primary objective of the study is to measure the diagnostic performance of pet/ct (with tracers used in our center for nuclear medicine by normal clinical practice), in the identification of malignancy of thyroid or parathyroid findings, compared to cytological/histological examination in patients with known thyroid and/or parathyroid disease or in patients with incidental findings. the secondary objective is to find functional parameters and predictive imaging of malignancy/benign and risk class of the lesion.

Eligibility criteria:
inclusion criteria: for the retrospective part: * patients aged \>18 years, * findings of hypercaptant of thyroid/parathyroid relevance to pet/ct or known thyroid or parathyroid pathology and subsequent execution of pet/ct according to normal clinical practice, * patients with cytological examination derived from needle aspiration performed no more than 12 months time apart from pet/ct. * obtaining informed consent for the prospective part: * patients aged \>18 years, * finding hypercaptant findings of thyroid/parathyroid relevance to pet/ct or known thyroid or parathyroid pathology and subsequent execution of pet/ct according to normal clinical practice. * patients scheduled for agesult to be no more than 12 months. * obtaining informed consent exclusion criteria: * nothing

Keywords: pet/tc 18f/fdg hyperparathyroidism
experiences from pregnancy and post-partum period in women with a history of eating disorders.

Conditions: Pregnancy Related; Eating Disorders; Bulimia Nervosa; Binge-Eating Disorder; Post Partum Depression

Summary: women with the eating disorder bulimia nervosa (bn) have been found to have a higher risk of unplanned pregnancies than healthy women, and experience greater miscarriage, premature birth, birth complications, and postpartum depression. other studies have found that women with eating disorders seem to find motivation to refrain from the eating disordered behavior for the sake of the fetus, but that it is highly different whether this gives sustained or only a temporary remission. eating disorders are rarely detected in the primary health care service, nor during pregnancy or during follow-up in fertility clinics. meeting a health care provider in the pregnancy care service who does not know about the eating disorder or who does not understand the disease well enough, can also make the management and experience of pregnancy and weight gain extra difficult. the aim of this study is to increase the knowledge on how women with a history of eating disorder experience their bodily changes, and how they experience the health service in pregnancy care and post-partum period.

women with the eating disorder bulimia nervosa (bn) have been found to have a higher risk of unplanned pregnancies than healthy women, and experience greater miscarriage, premature birth, birth complications, and postpartum depression. having a disorder in which the overevaluation of the need to control body weight and food intake is pertinent, may cause a tremendous mental challenge to accept the bodily change through a pregnancy. other studies have found that women with eating disorders seem to find motivation to refrain from the eating disordered behavior for the sake of the fetus, but that it is highly different whether this gives sustained or only a temporary remission. eating disorders are rarely detected in the primary health care service, nor during pregnancy or during follow-up in fertility clinics. meeting a health care provider in the pregnancy care service who does not know about the eating disorder or who does not understand the disease well enough, can also make the management and experience of pregnancy and weight gain extra difficult. the aim of this study is to increase the knowledge on how women with a hisory of eating disorders experience bodily changes through pregnancy, and how the pregnancy care service is experienced. the purpose of this data collection is to help design preparatory information for women with eating disorders who become pregnant, and to promote best practice guidelines for the health service in the meeting with, and follow-up of, pregnant women with a history of eating disorders.

Eligibility criteria:
inclusion criteria: * previous participant in the ped-t project * previous/current diagnosis of bulimia nervosa or binge eating disorder * has accepted to take part in the long-term follow up study in the ped-t project * has been/are pregnant exclusion criteria: * not matching the above criteria
effectiveness basket wires for the maintenance of stone and pneumatic probe in the treatment of ureteral stones

Conditions: Ureter Stone

Summary: patients included in the study included the necessary tests u / a, k, na, cr, bun, cbc, and u / c was checked and anesthesia counseling was done. patients were prepared for action. the demographic and clinical data of the patients, including age, sex, size, and location of the stones were recorded. then patients as random allocation were divided into two groups: a (control group, no basket of bases and group b (use of pneumatic synchronous buccal waist). the dividing person and the patients themselves were not aware of which group they were in. they were double-blind was. in each group, ureteroscopy was performed using a standard f9.5 ureteroscope. after reaching the rock in group a (control), the probe of the pneumatic crusher was passed through the working channel of the ureteroscope and began crushing the rock. during the crushing process, the minimum flow of water, flattening and the single-shot impact was used to minimize the stone's retropulsion. in group b (using a basket of wires3f) the helical type was passed through the four wires of the working channel of the ureteroscope and routed to the proximal part of the rock, and the stone was routed to the bowl, then the stone was ducted the gasket was kept, and the probe of the pneumatic crusher also passed through the working channel and proceeded to break it down. conditions were observed during the stomach as the control group. ureteroscopic crushing was performed by a urologist in both groups under similar technical conditions. findings during and after the completion of crushing include the success, stone retropulsion or parts larger than 3 mm, which requires secondary measures (swl - ureter stenting, resection ureteroscopy), the duration of stone breakdown and traumatic ureteric complications in both groups it is registered.


Eligibility criteria:
inclusion criteria: * individual interest in engaging in research * patients with ureter stones * symptoms of severe and resistant to supportive and therapeutic treatment * ureteral stones cause ureteral obstruction * ureteral stones, which is not likely to be disposed of by duration and size, have been selected for ureteroscopic lithotripsy. exclusion criteria: * patients with urinary tract infection * not having a proper cardiovascular condition and not approved by a cardiologist or anesthetist * patients who are dissatisfied with ureteroscopic crushing and patients who do not have access to rocks during ureteroscopic surgery * individual interest in leaving the study

Keywords: ureterolithiasis manganese poisoning lithotripsy ureteroscopy stone baske
the icon study: outcomes after fmt for patients with ibd and cdi

Conditions: Inflammatory Bowel Diseases; Clostridium Difficile Infection

Summary: in this study the investigators will evaluate patients with ibd and and at least 2 confirmed c.difficile infections who will be undergoing fmt. the investigators will assess patients before fmt and then follow patients prospectively post fmt at week 1, 8 and 12 to assess for recurrence of c.difficile infection and ibd outcomes.


Eligibility criteria:
inclusion criteria: * adults age 18 or greater * confirmed recurrent cdi by positive pcr or eia toxin test defined at ≥ 2 episodes and vancomycin failure within one year with the most recent being within the past 3 months. * confirmed diagnosis of ibd with colonic involvement (ulcerative colitis, crohn's colitis or ileocolitis or indeterminate colitis) for ≥ 3 months * undergoing fmt via colonoscopy for cdi as part of standard medical care exclusion criteria: * unable or unwilling to undergo a colonoscopy * inpatient status * anticipated immediate or upcoming surgery within 30 days * need for continued non-anti-cdi antibiotic therapy * history of total or subtotal proctocolectomy * isolated ileal or small bowel disease * pregnancy or lactation * female patients who are pregnant or breastfeeding or plan to become pregnant in the next 6 months. * patients who are unable to give informed consent * participation in a clinical trial in the preceding 30 days or simultaneously during this trial * severe food allergy (anaphylaxis or anaphylactoid-like reaction) * life expectancy \< 6 months * unable to adhere to protocol requirements * any condition that the physician investigators deems unsafe, including other conditions or medications that the investigator determines that it will put the subject at greater risk from fmt * known concurrent hiv, hepatitis b or c infection * concurrent psc * patients with wbc\< 3.0 x109th/l at baseline * patients with platelet count \< 100 x109th/l * patients with initial elevation of ast or alt \> 1.5 times above normal limit at baseline * non - steroidal anti-inflammatory medications (nsaids) as long-term treatment, defined as use for at least 4 days a week each month * treatment with vancomycin or metronidazole for more then 60 days prior to enrollment

Keywords: fmt ibd
sexual intercourse and vaginal absorption of progesterone

Conditions: Infertility

Summary: the objective of this project is to compare the vaginal absorption of progesterone administered in the vaginal ovum by measuring progesteroneemia in 3 situations (or "sexual event"): abstinence, sex protected by condoms and unprotected sex.

progesterone plays a key role in embryo implantation and maintenance of pregnancy. in the context of assisted reproduction (art), support for the luteal phase is often necessary and readily provided by the administration of progesterone, mainly vaginal in europe. optimal absorption is essential because low progesterone levels are associated with the chances of lowered pregnancies. however, it has been shown that vaginal absorption can be reduced following unprotected sex. would the use of a condom prevent this alteration of vaginal absorption?

Eligibility criteria:
inclusion criteria: * couples, volunteers, on an amp journey * having sexual intercourse with a low risk of transmission of sexually transmitted infection * free and informed consent to participate in the study inclusion criteria specific to women: * aged 18 to 40 inclusive exclusion criteria: exclusion criteria specific to women: * currently taking hormone therapy that may alter progesteroneemia * pathology that can modify progesteroneemia * body mass index greater than or equal to 32 kg / m2 * contraindication to the use of hormone replacement therapy * known intolerance to vaginal progesterone * pregnant woman (βhcg assay positive) or breastfeeding exclusion criteria specific to men: * erectile or ejaculatory disorder exclusion criteria specific to couples: * person with poor oral and/or written french comprehension * person who for psychological, social, family or geographical reasons could not be followed regularly * vulnerable person (article l1121-6 of the public health code) * protected person or unable to give consent * person involvment in another clinical research * person not affiliated with a french social security scheme or beneficiary of such a scheme

Keywords: progesterone vaginal absoption intercourse assisted reproductive technology
effects of triptorelin pamoate in children with precocious puberty - follow up study

Conditions: Precocious Puberty

Summary: the purpose of the protocol is to assess the efficacy of triptorelin 11.25 mg with respect to the proportion of children who maintain a regression or stabilisation of sexual maturity until the end of the study.


Eligibility criteria:
inclusion criteria: * the child must have completed study 2-54-52014-143 * the child must have an effective response to 2 injections of triptorelin 11.25 mg according to investigator's evaluation with no significant treatment side effects exclusion criteria: * the patient has a known hypersensitivity to any of the test materials or related compounds * the patient is unable or unwilling to comply fully with the protocol
improved basophil activation test (bat) in the diagnostics of drug allergy

Conditions: Drug Allergy; Antibiotic Allergy; NSAID-Induced Anaphylactoid Reaction

Summary: current study evaluates the use of the improved basophil activation test (bat) in the diagnostics of ige-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (nsaids).

current study evaluates the use of the improved basophil activation test (bat) in the diagnostics of ige-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (nsaids). among commonly used cd63/cd203c markers, newly proposed molecules, such as cd69, cd107a, cd164, cd13, cd11b and cd300a will be assayed. results obtained together with the other clinical data will be used to calculate sensitivity and specificity of the method.

Eligibility criteria:
inclusion criteria: * suspected allergy to antibiotics or nsaids in the last 1 year. exclusion criteria: * autoimmune diseases; * hiv; * hepatitis b/c; * other acute or chronic infectious diseases; * malignant neoplasms; * leukemia; * other severe acute or chronic intercurrent diseases; * pregnancy/lactation; * refuse of patient to participate in the trial.

Keywords: allergy drug allergy basophil activation test flow cytometry
muscle oxygenation, functional capacity and frailty in kidney transplant recipients with and without inspiratory muscle weakness

Conditions: Renal Transplantation

Summary: the aim of this study was to compare respiratory function, muscle oxygenation, functional capacity, peripheral muscle strength, body composition, and frailty in kidney transplant recipients with and without inspiratory muscle weakness.


Eligibility criteria:
inclusion criteria: * patients with kidney transplantation * at least 6 months after the kidney transplant * not having regular exercise habits * voluntary participation in the study exclusion criteria: * having a musculoskeletal problem that may interfere with the tests * having neurological impairment * having chronic lung disease * having had any cardiovascular event in the last 6 months
trospium chloride vs tamsulosin in treatment of ureteral stent related symptoms:

Conditions: Ureter Stone; Quality of Life; Ureter Obstruction

Summary: this study will be conducted to compare the efficacy and safety of trospium chloride versus tamsulosin for treatment of ureteral stent related symptoms.

eligible patients will be randomized to one of the two treatment groups. group 1 patients will receive 30 mg of trospium chloride tablet twice daily, while group 2 patients will receive 0.4 mg of tamsulosin tablet once daily, until the stent is removed. ureteral stent symptoms questionnaire (ussq) will be used to evaluate the symptoms of the patients with dj stent after 2 weeks of inserting the stent.

Eligibility criteria:
inclusion criteria: * patients with double "j" (dj) stent after ureteroscopy or for drainage of obstructed kidney exclusion criteria: 1. patients with hypersensitivity to either trospium chloride or tamsulosin 2. patients with complications after dj insertion (such as fever, hematuria, perforation, stent migration). 3. patients receiving alpha blockers or anticholinergic medications for any other reason. 4. patients with history of orthostatic hypotension. 5. pregnant or breastfeeding females. 6. patients with hepatic impairment (child-pugh score \>9). 7. patients with severe renal impairment with creatinine clearance of less than 15 ml/min. 8. patients with narrow-angle glaucoma. 9. patients with history of urinary retention or gastric retention.

Keywords: ureteral stent ussq tamsulosin trospium chloride