Kornimate/medical-research-clean huggingface dataset:
stepped care for aphasia

Conditions: Aphasia; Stroke

Summary: this study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. compensation will be provided to participants with aphasia.


Eligibility criteria:
inclusion criteria: * 18-81 years old * native english speaker (english fluency by age 7) * aphasia as a result of a left-hemisphere ischemic or hemorrhagic stroke (wab-r aphasia quotient \< 93.8) * at least 1-month post-stroke * confirmation of left hemisphere stroke per medical records * discharged from hospital * participant is willing and able to consent for themselves. exclusion criteria: * uncorrected hearing or visual impairment that prevents completion of experimental activities as determined by self-report * history of other neurological disorder or disease beside stroke (e.g., dementia, traumatic brain injury) as determined by self-report and/or medical records * self-reported history of premorbid learning disability * severe auditory comprehension deficits (as indicated by a score of more than two standard deviations below norms on the auditory verbal section of wab-r)
effect of muscle strength on hamstring flexibility in children with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy; Muscle Strength; Lower Extremity; Hamstring Contractures

Summary: investigator researched that the effect of trunk and lower extremity muscle strength on hamstring flexibility in children with duchenne muscular dystrophy.

thirty children were asessed by physical therapist. nineteen children was level 1 and eleven children was level 2 according to brooke lower extremity functional classification scale.

Eligibility criteria:
inclusion criteria: * getting a duchenne muscular dystrophy diagnosis, * being in ambulatuar phases and independently climbing four stairs * to be cooperate to physioterapist's directions exclusion criteria: * having severe contracture in the lower extremity * having undergone surgery in the past 6 months

Keywords: duchenne muscular dystrophy muscle strength hamstring flexibility back muscle lower extremity
prevalence of weight related complications across diverse weight classifications - a large study in india, pakistan, philippines and vietnam

Conditions: Obesity; Obesity-related Complications

Summary: this study is investigating how common weight related health problems are in people of different weight categories in india, pakistan, philippines, and vietnam. the purpose of the study is to understand the prevalence of weight related health problems in different weight groups. participants will continue their normal care and will not get any treatment as part of this study; participants will continue receiving any treatments their doctor has prescribed. the study will last for about 2 years.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any study related activities (study-related activities are any procedure related to recording of data according to the protocol). * male or female aged 18 years or older at the time of signing informed consent. * presence of at least one weight-related complication. exclusion criteria: * participants less than 18 years of age at the time of signing informed consent. * pregnant women and individuals with recent weight loss due to illness, defined as more than 5 percent (%) weight loss in the past 6 months.
an observational study of post-cesarean delivery respiratory patterns using a non-invasive minute ventilation monitor (exspiron ™ system)

Conditions: Pregnancy; Analgesia; Respiratory Depression; Obstructive Sleep Apnea; Postpartum

Summary: the purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery. some women who undergo cesarean delivery may be at risk for respiratory complications related to opiate administration for post-operative pain. the primary aim of this study is to evaluate post-operative minute ventilation in women who undergo cesarean delivery using a novel method of non-invasive minute ventilation monitoring, and to see if there are predictive risk factors that may predispose women to post-operative hypoventilation.


Eligibility criteria:
inclusion criteria: * 18 years or older * planned cesarean delivery with neuraxial morphine for post-operative analgesia exclusion criteria: * non-english speaking subjects * patients who undergo urgent or emergent cesarean deliveries * patients who receive general anesthesia or do not receive neuraxial morphine

Keywords: respiratory depression postpartum neuraxial morphine cesarean delivery
evaluation of post-operative discomforts in children after extraction of temporary teeth

Conditions: Post-extraction Pain (PEP); Post-extraction Lip or Cheek Biting Injury (PEBI); Post-extraction Bleeding (PEB); Tooth Removal

Summary: this prospective observational study aim to evaluate discomforts after extraction of temporary tooth under local anesthesia. the first objective is to describe the prevalence of the post-extraction pain (pep), post-extraction bleeding (peb), post-extraction biting injury (pebi) in children, and the analgesic usage. the secondary objective is to define whether it is possible to determine a profile of patients or a type of extraction's procedure predictive to pep and administration of analgesics, peb or pebi.

125 children in range of 2-15 years indicated for tooth extractions will be included in this study. informed consent will be obtained from all individual participants included in this study. immediately after extraction and until the following day, parents will be asked to assess the post-operative discomforts and to administrate paracetamol (acetaminophen) as soon as the child expressed a pain score ≥2 evaluated on the faces pain scale-revised (fps-r). a structured form is designed to obtained information regarding the patient's age, gender, socioeconomic level, and cooperation of the child before and during anesthesia or extraction, influence of accompanying person, number of previous extraction, dental hygiene. moreover, details about the type of extraction; the indication of extraction (tooth decay, orthodontic treatment, obstacle, infection and traumatism), the type of tooth (incisor-canine or molar), the degree of root resorption, number of doses of local anesthetic, and presence of preexisting or per-operative pain are also collected.

Eligibility criteria:
inclusion criteria: * children in range of 2-15 years indicated for tooth extractions under local anesthesia. exclusion criteria: * patient under analgesic the day of the appointment or under non steroidal anti-inflammatory agents through 8 days before the extraction; * contraindication to paracetamol/acetaminophen; * incomplete mental health; * extraction under sedation (including nitrous oxide/oxygen) and under general anesthesia. * extractions of permanent tooth; child was also excluded from the study if parents could not be reached by phone within 32 hours after extraction and if the parents don't speak french.

Keywords: temporary tooth pain analgesic paracetamol acetaminophen
predicting visceral leishmaniasis in hiv infected patients

Conditions: Leishmaniasis, Visceral

Summary: in this cohort study, the investigators will study the asymptomatic period preceding the onset of active visceral leishmaniasis (vl) in hiv-infected individuals from vl endemic regions in ethiopia as an avenue to develop an evidence-based screen and treat strategy to prevent progression to active vl.

hiv co-infection drastically increases the risk of developing active vl. clinical outcomes are dire in immune-compromised patients even with the best available treatment, and relapse is frequent. the incubation period may provide an important window of opportunity for a pre-emptive "screen an treat" approach in hiv co-infected patients to prevent progression from infection to the active disease. however, no recommendations exist to date due to lack of solid evidence. it is not known which patients are at highest risk of disease progression, which role parasite/host/hiv factors play in the asymptomatic infection phase, and what the diagnostic values of existing leishmania infection markers are. such information is needed to develop a prognostic clinical tool for the detection of hiv patients at high risk of developing active vl. therefore, the aim is to study the asymptomatic period preceding the onset of active vl in hiv-infected individuals from vl endemic regions in ethiopia as an avenue to develop an evidence-based screen and treat strategy to prevent progression to active vl. this will be a prospective cohort study with one year of follow-up for patients who remain vl free. patients developing active vl during the study period will be followed until the end of the study duration.

Eligibility criteria:
inclusion criteria: * confirmed hiv-positive * enrolled in hiv care at the study site exclusion criteria: * age under 18 years * diagnosis of active visceral leishmaniasis at enrolment * unlikely to seek health care again at this site during the next two years * not able or willing to provide informed consent. for patients not able to provide informed consent: no guardian available or willing to provide ic * medical emergency, underlying chronic medical condition, or other circumstances that make adherence to the study unlikely, or participation in the study medically inadvisable.

Keywords: leishmaniasis, visceral, neglected, hiv, co-infection, asymptomatic, ethiopia
effects of chest physiotherapy exercise in prevention of pre and post operative complications by cardiac surgery

Conditions: Surgery-Complications

Summary: "a randomized control trial will be conducted among 189 patients who have undergone cardiac surgery in past. the participants for this research will be patients of pakistan institute of cardiology, university of lahore teaching hospital, azra naheed medical college and bahria international hospital. the chest physiotherapy technique will be applied on 2 controlled groups. in 94 patients the effects of chest physiotherapy will be checked post - operatively and the effects will be checked on other half pre - operatively. the data will be gathered on practical performance and treatment based along with questionnaire. the data collected will then be analyzed using spss"


Eligibility criteria:
inclusion criteria: * patients undergoing in cardiac surgery like, cabg, univalve, bivalve and trivalve. exclusion criteria: * valve and cabg surgery combined with other cardiac surgery like percutaneous valve replacement. * cognitive disorder of the heart.
comparison of femto-laser and manually created clear corneal incisions during cataract surgery

Conditions: Cataract

Summary: the aim of this study is to test the hypothesis, that in terms of surgically induced corneal astigmatism (sia), higher-order aberrations (hoa), and wound geometry the femtosecond clear corneal incisions (ccis) created during cataract surgery are not inferior when compared to manual ccis. the potential risks associated with application of the femtosecond laser in this study are no greater or in most cases less than those associated with the standard manual cataract surgical procedure, and the potential benefits (such as precision and reproducibility) are greater than with the standard manual cataract surgery. therefore, the risk-to-benefit ratio is very low, such that the potential benefits for a subject participating in this study exceed the potential risks


Eligibility criteria:
inclusion criteria: * eligible to undergo cataract extraction by phacoemulsification with primary intraocular lens implantation * able to co-operate with the docking system for the femtosecond laser * clear corneal media * 40 years of age or older * willing and able to return for scheduled follow-up examinations exclusion criteria: * minimal and maximal k-values of the central 3mm zone that differ by more than 5d on a keratometric map of the cornea * maximum k-value that exceeds 58.d * minimal k-value of less than 37.d * corneal disease or pathology, such as corneal scaring or opacity, that precludes transmission of laser wavelength or that distorts laser light * poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally * manifest glaucoma+oht (ocular hypertension), pseudoexfoliation * previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye * known sensitivity to planned concomitant medications * history of lens or zonular instability * keratoconus or keratectasia * immune compromised or diagnosis of connective tissue disease, clinically significant atopic disease, insulin dependent diabetes mellitus, autoimmune diseases, ocular herpes zoster or simplex, endocrine diseases, lupus, ra, collagenosis and other acute or chronic illnesses that increases the risk to the subject or confounds the outcomes of this study, in the opinion of the study pl. * anterior chamber depth (acd) \ 4.8 mm as measured from the corneal endothelium. * extensive corneal scarring, pterygium * developmental disability or cognitive impairment (would preclude adequate comprehension of the ic form and/or the ability to record the study measurements) * concurrent participation in another ophthalmological clinical study

Keywords: induced corneal astigmatism clear corneal incisions femto-laser
personalized fingertip glucose measurement with a touch sensor

Conditions: Diabetes Mellitus

Summary: self-testing of glucose by patients living with diabetes mellitus (dm) involves needles, which causes discomfort or inconvenience eventually lead to decreased willingness to perform such needle-based check-ups that are vital to dm management. while technology has evolved, currently there is no glucose monitoring device that is needle-free. the investigators are studying a glucose sensor that detects glucose non-invasively, from sweat on an individual's fingertip. as it has not yet been tested in individuals with dm, the team will examine its accuracy and acceptability in these patients. results from this clinical trial could serve as the basis for further development of a non-invasive glucose sensor.


Eligibility criteria:
inclusion criteria: * an existing diagnosis of diabetes mellitus, either t1dm or t2dm, or any other type or etiology of diabetes * having a hemoglobin a1c \< 9.0%, and taking medication for diabetes. individuals will bring their own lab report. * ability to provide informed consent for participation. exclusion criteria: * individuals without diabetes * uncontrolled medical conditions, including diabetes with a hemoglobin a1c \> 9.0%, hypertension, heart, kidney, or liver failure. * those who cannot speak or read english. participation will be limited to those who read and speak english, as this is a pilot study of a small number of participants, that will very unlikely offer the prospect of direct benefit from participating. * individuals who have frequent hypoglycemia, hypoglycemia unawareness, or who are at high risk for hypoglycemia.
an observational study of tarceva (erlotinib) in routine daily clinical practice as second line treatment in patients with non-small cell lung cancer

Conditions: Nonsquamous Nonsmall Cell Neoplasm of Lung

Summary: this observational study will evaluate the safety and efficacy of tarceva (erlotinib) in routine clinical practice as second-line treatment in patients with recurrent or metastatic non-small dell lung cancer (nsclc). data will be collected from patients who have received 1 course of standard systemic chemotherapy, experienced disease progression, and who are receiveingtarceva in a second-line setting. patients will also be followed through third-line treatment if there is disease progression on tarceva therapy.


Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years of age. * written informed consent. * recurrent or metastatic, stage iii or iv non-small cell lung cancer (nsclc). * measurable disease (response evaluation criteria in solid tumors). * eastern cooperative oncology group (ecog) performance status of 0-2. * prior course of standard systemic chemotherapy. exclusion criteria: - contra-indications to treatment with tarceva.
diabetic cardiomyopathy

Conditions: Diabetic Cardiomyopathies

Summary: diabetes represents one of the 10 leading causes of death in the world and concerns 5% of the french population (\> 3.3 million patients). about 30% of diabetic patients will develop heart failure. the specific and early identification of diabetic cardiomyopathy at a subclinical stage (asymptomatic patients with normal lvef) will thus make it possible to predict the risk of the onset of heart failure and to strengthen their monitoring and further adapt their treatment.


Eligibility criteria:
inclusion criteria: * adult patient (≥18 years old) * type 2 diabetic and hypertensive subjects, cardiac asymptomatic, without myocardial ischemia documented by dobutamine stress ultrasound (esd), having at least 1 additional cv risk factor among: dyslipidemia, active or stopped smoking for less than 3 years, family history (1st degree relationship) of major cv accident before age 60, obliterating arteriopathy of the lower limbs and / or carotid atheroma, or proteinuria. * subject not having expressed his opposition, after information, to the reuse of his data for the purposes of this research. exclusion criteria: * patient who expressed his opposition to participating in the study * valvular heart disease (moderate to severe valve disease), hypertrophic or dilated (mvgi\> 95 g / m2 in women and mvgi\> 115 g / m2 in men), chronic pulmonary; * history of cardiotoxic chemotherapy; * subject under legal protection, under guardianship or under guardianship.

Keywords: diabetes cardiomyopathy diabetic cardiomyopathies type 2 diabetes echocardiography left ventricle strain 2d and 3d
tspo-pet/mri in surveillance of neuroinflammation in the central nervous system

Conditions: Central Nervous System Diseases

Summary: central nervous system (cns) inflammation is an immune response activated in the brain and spinal cord by microglial cells and astrocytes, commonly occurring under conditions such as central nervous system ischemia, autoimmunity, infection, toxins, and trauma. microglial cells, as the innate immune cells of the central nervous system, are responsible for driving the inflammatory response and play a crucial role in sensing environmental changes, responding to harmful stimuli, and engulfing dead neurons. they also present antigens to t lymphocytes, mediating interactions between the peripheral immune system and the central nervous system. factors released by neuronal cells can either promote or inhibit inflammation, and monitoring the level of inflammation driven by microglial cells is essential for the diagnosis and treatment of central nervous system diseases. mri is the primary imaging method for central nervous system inflammation, but it can be challenging to diagnose. pet/mr, a technology that integrates pet and mr imaging, provides high-quality diagnostic images and is valuable for the early detection, diagnosis, and assessment of central nervous system diseases. the radioactive ligand 18f-dpa-714 pet, targeting the translocation protein (tspo), can visualize activated microglial cells, which may have a gain effect in detecting active central nervous system inflammation. this study aims to explore the application of 18f-dpa-714 pet/mr in the early diagnosis, treatment evaluation, and prognosis of central nervous system inflammation.


Eligibility criteria:
inclusion criteria: -clinical diagnosis of ischemic stroke, autoimmune ecephalitis, neuromyelitis optica spectrum disorders, or multiple sclerosis, etc.al exclusion criteria: * claustrophobia * metal implants * pregancy * breast-feeding * renal insufficiency (gfr \< 60 ml/min/1.73m2) * allergy or other contraindication to gadolinium-based mr contrast agent
digital rewards and retention in a m-health app

Conditions: Transdiagnostic Psychopathology; Attrition; Engagement; Depression, Anxiety; Stress

Summary: attrition and user engagement are two challenges that ehealth interventions struggle with. attempts to address this have been previously made through gamification, instructional design and using different types of incentives. overall, any type of reward, be it non-financial or monetary is better than the controls, but the latter usually produce a greater effect. it is also worth mentioning that having an affective value attached to the reward itself is also important to user retention and engagement. given the ever-increasing interest in cryptocurrency and its current relevance, the present study - a randomized clinical trial with three arms - aims to compare cryptocurrency to non-monetary rewards regarding their effectiveness in reducing attrition and increasing engagement. in order to do this, a mental-health computerized intervention will be developed, in which the users will have to complete several modules, during which time they will be rewarded either with cryptocurrency, sweepstake rewards (e.g., vouchers), or nothing.

albeit effective, ehealth interventions suffer from very high dropout rates. finding novel ways in which to maximise user retention and engagement in such settings can be beneficial, and exploring cryptocurrency as a potential reward may be worthwhile, since motivation seems to increase as the reward is perceived as more meaningful by the recipient. the design is experimental, between-subjects, with one independent variable (the type of reward offered) and mental health (e.g., depression, anxiety, stress, and transdiagnostic constructs) as well as engagement and retention outcomes. thus, three groups will be formed: two in which participants will be enrolled in the modular moto intervention and will receive different rewards, and one in which they will not receive any intervention or reward but will be evaluated as part of a waitlist control group. the modular moto intervention involves, in addition to the mentioned assessments, the completion of six weekly modules, each focused on specific aspects of mental health and containing exercises that may improve psychological well-being. these modules are automated, requiring no interaction with others (except for communication between participants and research team). each of these modules contains the following: psychoeducational section(s) that participants must complete; a short test of 5-10 questions after each section to assess understanding of the material; (only for the first two groups); a link where they can obtain their rewards; the exercise corresponding to that module; the evaluation corresponding to that module.

Eligibility criteria:
inclusion criteria: * english speaking exclusion criteria: -

Keywords: crypto digital rewards mhealth attrition cbt nft