Kornimate/medical-research-clean huggingface dataset:
a lifestyle intervention programme using mobile application vs booklet for adults with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the study aims to compare the effect of a lifestyle intervention programme (lip) using mobile application (mets app) vs using booklet for mets adults living in the community.

the study aims to compare the effect of a lifestyle intervention programme (lip) using mobile application (mets app) vs using booklet for mets adults living in the community. methods a multi-site randomized controlled trial (rct) with three arms, namely, mets app group (group a), booklet group (group b), and control group (group c). three hundred and sixty subjects will be recruited from six community centers and randomized into either one arm. inclusion criteria are those mets adult, able to use a smart phone. group a participants will receive a 30-minute educational session and a mets app while group b will receive same educational session and a mets booklet and the control group receive a placebo booklet only. the mets app or booklet, has been well developed by the team with the support of internal grant, aims to support mets individual's self- monitoring and record of health measures (body weight, blood pressure, waist circumference) and exercise. the primary outcomes of this study include the body weight and total physical exercise (gsltpaq). the secondary outcomes include cardiometabolic risk factors, cardiovascular endurance, self-efficacy for exercise (see) and stress level (pss-10). data will be collected at baseline (t1), 4 week (t2) and week 12 (t3) and week 24 (t4). spss and generalized estimating equations (gee) model will be employed for data analysis. significance this study will provide empirical evidence and inform about the effective way to enhance patient's self-management of mets, exercise sustainability that will be beneficial to clients' health.

Eligibility criteria:
inclusion criteria: 1. ethnic chinese client who has a smart phone. 2. adult age 18 or over 3. mets clients with central obesity (male \>90 cm , female \> 80cm ) plus two items of the followings : * raised triglycerides ≥ 150 mg/dl (1.7 mmol/l) or specific treatment for this lipid abnormality * reduced hdl cholesterol \< 40 mg/dl (1.03 mmol/l) in males \< 50 mg/dl (1.29 mmol/l) in females or treatment for this lipid abnormality * raised blood pressure systolic bp ≥ 130 or diastolic bp ≥ 85 mm hg or treatment of previously diagnosed hypertension (ht) 4. raised fasting plasma glucose (fpg) ≥ 100 mg/dl (5.6 mmol/l), or previously diagnosed type 2 diabetes (dm) - exclusion criteria: * clients with physical, mental, visual, or cognitive impairments with regular medical follow-ups and treatment, and those who have musculoskeletal disorders or other disabling diseases that may limit the practice of walking exercise will be excluded. client receiving prescription of medication for weight reduction will be excluded as well.

Keywords: life style modification program mobile application booklet exercise body weight randomized control trial metabolic syndrome adult
pericapsular nerve group block chemical neurolysis in advanced hip osteoarthritis

Conditions: Osteoarthritis; Osteoarthritis, Hip

Summary: peng neurolysis in advanced osteoarthritis of the hip joint.

the study aims to assess the safety and effectiveness of regional pain treatment methods and their impact on the quality of life of patients with advanced osteoarthritis of the hip joint.

Eligibility criteria:
inclusion criteria: * patients of the pain treatment clinic of the transfiguration of jesus clinical hospital of the medical university of poznań will be qualified for the study * patients with coxarthrosis or gonarthrosis who failed to achieve satisfactory pain control (nrs\>3) despite the use of nsaids, paracetamol, and co-analgetics * age of patients: from 18 to 110 years of age. * caucasian patients can give informed, complete, written consent. exclusion criteria: * suspected or diagnosed opioid dependence syndrome * active cancer * dementia
manicaland vmmc uptake through behavioural incentives trial

Conditions: HIV/AIDS

Summary: primary objective the purpose of this study is to evaluate the impact of an interactive vmmc education session offered by a circumcised health worker and contribution to transport costs for accessing vmmc along with either (1) conditional economic compensation for wages or (2) lottery-based economic incentives on the uptake of vmmc. hypothesis vmmc education session offered by a role model - a young male health worker who has been previously benefited from vmmc services in this community - addressing risks of hiv infection, benefits of vmmc, and the fear of pain associated with vmmc, with/without a conditional fixed or lottery-based financial incentives off-setting present-biased preferences, will improve risk perception and increase uptake of vmmc in hiv-negative young men. study outcomes the primary outcomes for the study will be risk perception measured in a follow-up survey at 6 months and proportion of men taking up vmmc within 6 months measured through self-reports and matched to program records.


Eligibility criteria:
inclusion criteria: * men * age 15-29 years exclusion criteria: * participants testing hiv-positive at baseline * self-reporting have already undergone circumcision

Keywords: voluntary medical male circumcision hiv prevention risk perception
a trial of reconstruction after distal gastrectomy for gastric cancer

Conditions: Gastric Cancer

Summary: the purpose of this study is to evaluate the quality of life (qol) after billroth-i reconstruction (b-i) following distal gastrectomy, compared with roux-en y reconstruction (r-y) in patients with gastric cancer.

the purpose of this study is to evaluate the quality of life (qol) after billroth-i reconstruction (b-i) following distal gastrectomy, compared with roux-en y reconstruction (r-y) in patients with gastric cancer. there is no prospective randomized study of the two operative procedures focusing on postoperative qol. the investigators conducted a prospective randomized trial on 120 patients who underwent distal gastrectomy comparing billroth-i reconstruction and roux-en y reconstruction. the primary endpoint was the postoperative qol. the secondary endpoints were the incidence of postoperative complications, nutritional status, and the incidence of the remnant gastritis and the reflux esophagitis. patients were recruited into this study before surgery, on the basis of whether distal gastrectomy was anticipated at wakayama medical university hospital(wmuh) for gastric cancer, and appropriate informed consent was obtained. exclusion criteria was 1) patients with severe complications which were possible to prolong hospital stay, 2) patients with history of other organ malignancies, 3) patients who were diagnosed inadequacy for this study by a physician, and 4) patients without an informed consent.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of stomach * performance status: eastern cooperative oncology group (ecog) 0-1 * tumor located in the antrum or the angle or the lower body of stomach * appropriate informed consent was obtained. exclusion criteria: * patients with severe complications which were possible to prolong hospital stay * patients with history of other organ malignancies * patients who were diagnosed inadequacy for this study by a physician * patients without an informed consent

Keywords: distal gastrectomy billroth-i reconstruction gastric cancer qol
effects of denosumab on bone fusion in osteoporotic patients after lumbar fusion

Conditions: Osteoporosis; Fusion of Spine, Lumbar Region

Summary: lumbar fusion is an accepted and effective technique for the treatment of lumbar degenerative disease. as the population ages, disability associated with spinal pathology and spinal surgery is rapidly increasing and there is a concomitant increase in prevalence of osteoporosis which is a detrimental factor for lumbar fusion and instrumentation. osteoporosis-related bone fragility is a primary reason for spinal fusion failure, implant fixation failure, and vertebral compression fractures above or below the fusion sites. denosumab is a human monoclonal antibody against rankl, it inhibits osteoclast mediated bone destruction and has been found to be effective in treating osteoporosis, including reducing bone turnover markers, increasing bone mineral density (bmd), and reducing fractures. but few studies focus on the effects of denosumab on lumbar fusion. in this study, we include osteoporotic patients with lumbar degenerative disease who have had lumbar interbody fusion surgery. the patients were randomized to either treatment of denosumab or no treatment. all these patients are followed at 3, 6, 9, 12 months postoperation. during these periods, we detect bone metabolism and bone fusion of these patients. finally, we would report whether denosumab can improve bone metabolism and promote bone fusion or not.


Eligibility criteria:
inclusion criteria: 1. diagnosis of degenerative lumbar diseases with symptoms of low-back pain and/or leg pain for at least 3 months, which was not be adequately controlled by nonoperative treatments. 2. diagnosis of osteoporosis, defined as a bone mineral density (bmd) at lumbar or femoral neck with 2.5 standard deviations or more below the mean peak bone mass (t scores \<-2.5 sd) measured by dual-energy x-ray absorptiometry (dxa). 3. patients will be underwent single-level or two-level lumbar interbody fusion. exclusion criteria: 1. paget disease of bone, 2. low laboratory tests for calcium, 3. previous radiation treatment or fusion surgery to lumbar spine, 4. bone tumors, 5. bone infection, 6. acute vertebral fractures 7. severe spinal deformities such as degenerative scoliosis, 8. other metabolic bone disease, 9. history of a anti-osteoporosis medication 10. combined with severe morbidities, 11. uncorrected bleeding diatheses 12. application of steroids.
efficacy of pregabalin in the treatment of pancreatic cancer pain. a randomized controlled double-blind, parallel group study

Conditions: Pancreatic Cancer; Visceral Pain

Summary: this is a randomized, double blind controlled, parallel arms trial, aimed to assess the efficacy of pregabalin on pancreatic cancer induced abdominal pain. the goals of this study include (1) assessing the analgesic effect of pregabalin in comparison to placebo; assessing the presence of central sensitization and its potential reversion by pregabalin; (3) assessing quality of life of patients treated with pregabalin in comparison to placebo; (4) to compare adverse effects in patients treated with pregabalin in comparison to placebo; (5) to compare anxiety and depression in patients treated with pregabalin in comparison to placebo.


Eligibility criteria:
inclusion criteria: * 1. patients \> 18 years old recently diagnosed of pancreatic cancer (\<3 months). * 2. personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the trial. * 3. patients willing and able to comply with the scheduled visits, treatment plan, laboratory tests and other trial procedures. exclusion criteria: * 1. patients with evidence or history of medical or surgical disease of importance for this study as judged by investigator. * 2. patients with previously diagnosed moderate to severe renal impairment. those with a clearance of creatinine (clcr) \< 60ml/min should be excluded. * 3. patients treated with anticonvulsants during the previous 4 months.
left atrial monitoring in patients before and after mitral surgery - lambda study

Conditions: Mitral Regurgitation; Mitral Valve Disease; Heart Failure

Summary: mitral valve leakage, or mitral regurgitation (mr), is associated with heart failure symptoms including shortness of breath, fatigue, irregular heart rate. when left untreated, it may cause death. patients with mr can be divided in two broad groups: those with primary mr, caused by disease of the mitral valve structures, and those with secondary mr, due to dilation of the heart chambers. our study focuses on patients with primary mr. the standard treatment for severe symptomatic primary mr is mitral valve surgery, a type of open-heart surgery. the outcomes following this procedure are excellent, however, a subset of patients continue to experience heart failure symptoms after surgery due to very high pressures in the heart, more specifically in the left atrium, which is one of the four heart chambers. this is called functional mitral stenosis (fms). previous studies have shown that creating a small opening between the left and right atria can help relieve the pressure inside the left atrium. we would like to determine whether creating this opening between the two atria at the time of mitral valve surgery can help prevent fms. to answer this question, we will study two groups of patients who need mitral valve surgery for primary mr. the first group will undergo mitral valve surgery, along with the creation of the opening between the two atria. the second group will undergo mitral valve surgery alone. we will then compare the outcomes between both groups, namely with regards to their heart failure symptoms after open-heart surgery.


Eligibility criteria:
inclusion criteria: * patients ≥18 years of age * severe (4+) symptomatic carpentier type ii mr due to degenerative disease * planned surgical mitral valve repair * right-to-left atrial pressure gradient ≥ 5 mmhg at baseline * pulmonary vascular resistance ≤ 4 wood units exclusion criteria: * secondary causes of mr and mixed mitral valve disease * infective endocarditis within 30-days * any prior mitral valve intervention * need for emergency intervention or surgery * left ventricular ejection fraction 2+
connective tissue massage with fibromyalgia

Conditions: Fibromyalgia

Summary: the aim of the study was to examine the effectiveness of clinical pilates exercises and connective tissue massage in individuals with fibromyalgia (fm). 32 women were randomly divided into two groups as intervention (n=15, mean age=48.80±7.48) and control (n=17, mean age=55.64±7.87). while connective tissue massage and clinical pilates exercises were applied to the intervention group, control group were applied only clinical pilates exercises.according to our results, connective tissue massage increased the effectiveness of clinical pilates exercises in individuals with fm.


Eligibility criteria:
inclusion criteria:(a) having fm diagnosis according to american college of rheumatology 2016 criteria, (b) being a women, (c) aged 20-65. (d) being stable in drug use for at least 6 months or more. (e) being volunteer to participate in this study. - exclusion criteria:(a) have been exercising regularly for the past three months, (b) the presence of uncontrolled cardiopulmonary disease, (c) the presence of orthopedic, neurological or mental problems that may prevent exercise, (d) having undergone any surgery in the last six months for both groups, (e) pregnancy, (f) presence of malignancy, (g) not being able to participate in at least 75% of the training. -
heel pain in adolescents: a pilot study on the effectiveness of exercise therapy and activity modification

Conditions: Sever's Disease; Achilles Tendinopathy; Insertional Achilles Tendinopathy; Apophysitis; Calcaneus

Summary: invesigators plan to conduct a 12-week longitudinal cohort study of 30 subjects with calcaneal apophysitis. subjects will be included if they are between 7-17 years-old, have experienced an insidious onset of heel pain with running or jumping activities, and have no underlying diagnosis predisposing heel pain and no other injury that limits their ability to run and jump. parents of subjects will be invited to participate by completing questionnaires related to their perspective of their child's symptoms, physical activity level, quality of life, and their satisfaction with the treatment protocol. subjects will be asked to attend 4 monthly sessions consisting of evaluation and treatment.

investigators will recruit 30 subjects between ages 7-17 with heel pain and also invite their parent/guardian to participate in this research study. participants will be evaluated at baseline, 4-weeks, 8-weeks and 12-weeks. data collections at each assessment visit will be identical except for the baseline visit. the baseline evaluation will consist of questionnaires related to past medical history in addition to all other procedures. all evaluations will include patient-reported outcome measures, clinical measures, and measurement of tendon structure, mechanical properties, and muscle-tendon function treatment sessions will occur immediately following the evaluation sessions (4 total). during treatment sessions, participants will be provided with education, therapeutic exercise instruction, and discussion of their training diary and home exercise program. treatment sessions will last 30-45 minutes. in addition to the 4 in-person treatment sessions, virtual visits will take place 2 weeks in between each in-person visits, (one virtual visit maximum every 4 weeks) as needed. virtual visits will be no longer than 30 minutes to discuss patient needs.

Eligibility criteria:
inclusion criteria: * insidious onset of heel pain with running or jumping activities lasting at least three weeks * location of pain is focal at the calcaneus over the achilles tendon attachment and/or the achilles tendon exclusion criteria: * subjects having an underlying diagnosis predisposing to heel pain (spina bifida, osteogenesis imperfecta, larsen syndrome, cerebral palsy) * history of calcaneal fracture or foot/ankle surgery in the past 6 months * another injury that limits the ability to perform exercises on the injured leg

Keywords: achilles tendon pain activity modification sever's disease achilles tendinopathy apophysitis exercise
safety and efficacy of human autologous peripheral blood stem cells for treatment of hbv-related liver cirrhosis

Conditions: Liver Cirrhosis; End Stage Liver Disease

Summary: hbv related liver disease is a common medical problem in china. an estimated 7.18% of the chinese (about 93 million) is infected with hepatitis b, and most of the hbv- related hepatitis can developed into liver cirrhosis. liver transplantation is the only available life saving treatment for patients with end stage liver disease. however, lack of donors, surgical complications, rejection, and high cost are serious problems. in preclinical studies the investigators have demonstrated that g-csf mobilized pbsc from patients with hbv related liver cirrhosis could differentiate into functional hepatocyte and autologous pbsc transplantation can significantly improve liver synthetic function. but further studied was needed to confirm the safety and efficacy of pbsc transplantation. in this study, a prospective, randomized, parallel clinical study was designed. the patients with hbv-related liver cirrhosis will undergo administration of human autologous pbscs via hepatic artery to evaluate the safety and efficacy of human autologous pbscs treatment for these patients.


Eligibility criteria:
inclusion criteria: 1. aged 18-65 years 2. hbv-related liver cirrhosis 3. child-pugh score 9-15 4. written consent exclusion criteria: 1. hepatocellular carcinoma or other malignancies 2. severe problems in other vital organs(e.g.the heart,renal or lungs) 3. pregnant or lactating women 4. severe bacteria infection 5. anticipated with difficulty of follow-up observation 6. other candidates who are judged to be not applicable to this study by doctors -

Keywords: liver cirrhosis stem cell peripheral blood autologous hbv end stage liver disease
combination of methotrexate(mtx) and actinomycin(actd) in the low risk gestational trophoblastic neoplasma （gtn） patients with score of 5-6

Conditions: Gestational Trophoblastic Tumor; Effects of Chemotherapy; Drug Toxicity

Summary: in this study, a prospective, multicenter randomized controlled study was conducted to compare the clinical efficacy and toxicity response of combination mtx+actd multi-course regimen in low-risk gtn patients with score 5-6 with standard mtx single-drug multi-course regimen.

the improved prognostic scoring system has been in use for more than 20 years in gtn patients. however, there are also more and more clinical evidences showing that the international federation of obstetrics and gynecology（figo）/world health organization (who) system is not so perfect. the main problem is that a considerable number of patients are resistant to initial chemotherapy, 25-35% occur in low risk (≤ 6 points), and 70-80% occur in patients with a score of 5-6 points. according to reference, the drug resistance factors include high hcg level before chemotherapy, metastatic foci, histological diagnosis of choriocarcinoma, etc. however, according to the score before 2000, there is a moderate risk score group with 4-6 points, i.e. most of the single drug resistance to the initial regimen occurs in the previous moderate risk score group.therefore, most scholars believe that there are grey areas with a score of 5-6. according to the analysis of 5-6 scores in the scoring system, the prognosis of single-drug chemotherapy is poor, and the initial remission rate is only about 30-40%. therefore, many authors call for the current staging scoring system to be revised to a more accurate model so that some patients who may be drug resistant can adopt more effective plans at the beginning of treatment. in this study, the investigators plan to conduct a prospective, multicenter randomized controlled study to compare the clinical efficacy and toxicity response of combination mtx+actd multi-course regimen in low-risk gtn patients with score 5-6 with standard mtx single-drug multi-course regimen. the experiment arm of the trial is multi-course combination of mtx and actd. the primary endpoint is complete remission rate of primary treatment or failure of primary treatment. drug toxicity is surveillanced.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of gestational trophoblastic tumor; * patients with prognosis score of 5 and 6 * primary chemotherapy (preventive chemotherapy is not included); * physical strength grade: karnofsky score ≥ 60; * wbc ≥ 3.5× 109/l, anc ≥ 1.5× 109/l, pt ≥ 80× 109/l, serum bilirubin ≤ 1.5 times of normal high limit, transaminase ≤ 1.5 times of normal high limit, bun, cr≤ normal; * follow-up and good compliance; * sign the informed consent form. exclusion criteria: * pathological diagnosis is intermediate trophoblastic tumor, including pstt and ett； * there are serious or uncontrollable medical diseases, which are not suitable for chemotherapy; * those who receive clinical trials of other drugs at the same time. * those who receive chinese medicine.

Keywords: gtn mtx actd
painful knee prosthesis. relationship between endogenous analgesia and persistent post surgical pain.

Conditions: Knee Osteoarthritis

Summary: this is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; tka) and the probability to develop chronic pain after surgery (persistent post surgical pain). endogenous analgesia efficiency will be measured during the month previous to surgery using quantitative sensory testing (qst). persistent post surgical pain will be defined as presence of pain in movement greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.


Eligibility criteria:
inclusion criteria: * older than 18 patients * scheduled for primary total knee arthroplasty * disposition to visits and scheduled tests exclusion criteria: * previous surgery on knee to be operated * documented peripheral neuropathy * severe disease or condition that could potentially interfere with interpretation of tests.