Kornimate/medical-research-clean huggingface dataset:
live well: a practical and effective low-intensity dietary counseling intervention for use in primary care patients with dyslipidemia

Conditions: Dyslipidemia

Summary: the purpose of this study was to evaluate the effects on lipids and diet of a low-intensity dietary counseling intervention provided by the primary care physician (pcp), in patients at risk for cardiovascular diseases

the objective of this study is to design and evaluate the feasibility and the effect on diet quality and blood lipids a new dietary counseling intervention that will be sustainable in the "real-world" settings of the current clinical practice. the intervention will be initiated by the primary care physician during the routine office visits and will use paper and web-based counseling materials. internet based healthcare, or e-healthcare, is a consumer focused health care delivery paradigm that physicians and the healthcare system can no longer ignore. lifestyle counseling and preventive medicine are potentially ideal areas of patient care that could be provided efficiently through this emerging venue of healthcare delivery. internet access is near-universal for americans under the age of 60: 90% of 18-29 year-olds, 85% of 30-49 year-olds, and 70% of 50-64 year-olds. the aims of this study are: 1) - develop a patient self-administered, computerized version of the paper-based rate-your-plate dietary screening questionnaire; 2) - create counseling materials on diet and cholesterol and build a secure, hipaa compliant, interactive web-based counseling application that will allow patients to receive personalized counseling base on the results of the screening dietary questionnaire and the goals chosen by the patients; 3) - to test the feasibility of this intervention in the clinical settings of primary care, and evaluate its effect on lipids panel at 3 and 6 months .

Eligibility criteria:
inclusion criteria: * eligibility required documentation of a ldl-cholesterol level of 130 mg/dl or higher within the 12 months prior to enrollment. potential subjects were also required to have access to the internet and an active email account. the use of lipid lowering drugs was not an exclusion, but patients taking these drugs had be on the same medication and dose for at least 3 months prior to enrollment, with no changes anticipated for the duration of the trial. exclusion criteria: * we excluded patients with poorly controlled diabetes mellitus (defined by hba1c\>9%), serum creatinine above 1.5 mg/dl, malignancy, cirrhosis, eating disorders, acute coronary syndrome in the last three months, congestive heart failure nyha class lll and lv, ongoing warfarin therapy, uncontrolled hypo- or hyperthyroidism, ongoing weight loss, history of bariatric surgery, pregnant women, and patients who scored more than 250 (on a scale of 100 to 300) on a food frequency questionnaire administered on the day of enrollment. patients with a history of triglycerides \>400 mg/dl were also excluded, since we used the friedewald formula \[ldl-c=total cholesterol-(tgs/5+hdl-c)\] to calculate ldl-cholesterol levels.

Keywords: diet counseling primary care
continuos body temperature monitoring

Conditions: Fever

Summary: this is a nonrandomized, diagnostic, single-center, pilot study, with one group of participants. the aim is to examine the effectiveness and safety of telemedicine system for continuous measurement of body temperature in adults. up to 40 subjects will participate in this phase of the clinical trial. no stratification, nor randomization of subjects will be performed. respondents who meet the inclusion criteria will be monitored for up to 72 hours plus 72 hours after removing the device. namely, the device will be placed on their body and will be there until upt to 72 hours, and then it will be removed. the respondent will be monitored by the team for an additional 72 hours by the person in charge of the examination, for possible side effects. sensor will be placed in the axilar joint or a little below on the side. the device will be connected to a mobile phone. member of the research team (principal researcher/co-researcher/ nurse in charge of examination) measures the temperature of the skin in the opposite armpit manually, ie with a gallium thermometer and records every 30-60 minutes. when body temperature starts to rise, a member of the research team measures the body temperature every 15-30 minutes. after reaching a stable temperature, the temperature is measured every 30-60 minutes. if the subject is given drugs to lower body temperature, the temperature is measured again every 15-30 minutes until the temperature stabilizes to a normal subfebrile state.


Eligibility criteria:
inclusion criteria: * a person of male or female sex * age 18 and over * ability to measure the patient's body temperature frequently * people who are hospitalized due to any type of infection or any other diseases that result in variations in body temperature (rise, fall) * completed all potential diagnostics of the hospitalized patient (no interrupting the measurement of the telemedicine device) exclusion criteria: * allergic to contact with plastic or silver * anatomical anomalies that prevent the placement of the system * high-risk health conditions, intensive care and the like * a pacemaker or other device on the skin or implanted in the body that emits light electromagnetic radiation
self-directed positive psychology intervention for newly diagnosed multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the goal of this clinical trial is to learn whether positive psychology (pp) exercises such as writing a letter of gratitude or remembering a past success can help individuals with newly diagnosed multiple sclerosis (ms) to feel more hopeful, happy, and healthy. the main questions it aims to answer are: * is a five-week self-directed pp training intervention feasible and acceptable to individuals with newly diagnosed ms? * does the completion of a five-week self-directed pp training intervention improve positive affect, emotional function and health-related quality of life (hrqol) in individuals with newly diagnosed ms? * are improvements in positive affect, emotional function and hrqol maintained after the completion of the intervention? participants will be randomized to the intervention or waitlist control group. there will be an intervention phase (weeks 1-5) and an extension phase (weeks 6-10). all participants will complete questionnaires at enrollment, 5 weeks and 10 weeks. they will complete 5 weeks of self-directed pp training exercises, either during the intervention phase (intervention group) or extension phase (waitlist control group) of the study. researchers will compare participants in the intervention and waitlist control groups at the end of the intervention phase to see if there are improvements in positive affect, emotional function and hrqol. for subjects in the intervention group who demonstrate improvement, researchers will determine if the benefit is maintained by comparing positive affect, emotional function and hrqol at the completion of the intervention and extension phases of the study.


Eligibility criteria:
inclusion criteria: * diagnosis of ms according to the mcdonald 2017 diagnostic criteria * onset of disease within the last 2 years * ability to speak, read and write in english exclusion criteria: • moderate or marked cognitive abnormalities identified by the treating neurologist during routine clinical visits that would preclude meaningful participation in the pp exercises

Keywords: positive psychology positive affect
point-of-care immunoassay for detection of bacterial sinusitis

Conditions: Sinusitis Bacterial

Summary: this study is conducted to evaluate the performance of a rapid, point-of-care in vitro diagnostic device (sinu-test®) for the qualitative detection of the three most common pathogens responsible for causing bacterial sinusitis.

mucous specimens will be collected from patients displaying symptoms of acute bacterial sinusitis enrolled by primary care and/or otolaryngology clinics in the united states. health care professionals not having endoscopy certification will collect specimens using the entvantage sample collection device. health care professionals with nasal endoscopy certification or specialty training will collect comparator specimens using an endoscope. untrained operators with a range of education and training (primary care physician, otolaryngologist, physician assistant, nurse practitioner, registered nurse or other healthcare professional), will perform the sinu-test® lateral flow assay in an outpatient setting. mucous samples will be tested for the presence of 3 bacterial pathogens responsible for sinusitis using the sinu-test® in the clinic and by a composite comparator method comprised of standard quantitative bacterial culture with identification (matrix-assisted laser desorption/ionization-time of flight (maldi-tof) mass spectrometry instrument) and semiquantitative real-time polymerase chain reaction (real-time pcr) of the residual culture sample and the sinu-test® residual swab performed by a central laboratory.

Eligibility criteria:
inclusion criteria: * meets definition of acute sinusitis by infectious disease society of america (2012) exclusion criteria: * chronic sinusitis * cystic fibrosis * patients treated with antibiotics currently or within the previous 30 days. * subjects with a prior history of sinus surgery will be excluded due to the modification of sinonasal anatomy. * primary immunodeficiencies, as self-reported * combined variable immunodeficiency * immunodeficiency with reduced immunoglobulin g (igg) and immunoglobulin a (iga)-bearing cells * kartagener syndrome (ciliary dyskinesia) * agammaglobulinemia * sickle cell disease * acquired immunodeficiencies, as self-reported * chemotherapy * radiation therapy * transplantation * asplenia * hiv * poorly controlled diabetes mellitus * cognitive impairment resulting in the inability to provide informed consent. * special groups, such as children under the age of 18, and men and women who are in prison will not participate in this study.

Keywords: acute sinusitis bacterial sinusitis point-of-care in vitro diagnostic device (ivd)
popular (preference of patient using levocetirizine in allergic rhinitis)

Conditions: Seasonal Allergic Rhinitis

Summary: comparative study on clinical efficacy and safety of levocetirizine and desloratadine as measured by the subject's satisfaction/dissatisfaction after one week of treatment


Eligibility criteria:
inclusion criteria: * clinical history of sar known and treated since 2 years. * positive skin prick test (wheal \> 3 mm larger than the diluent control) or rast (≥3.5 iu/ml) to grass pollen (less than 1 year). * minimum mean t5ss of 8 during the baseline period. exclusion criteria: * have an associated asthma requiring a daily treatment other than β2 short acting agonist prn * have atopic dermatitis or urticaria requiring antihistamine treatment or the administration of oral or topical corticosteroids and any other disease requiring the administration of oral or topical corticosteroids

Keywords: seasonal allergic rhinitis (sar), grass pollen, sar symptoms (sneezing, rhinorrhea, nasal / ocular pruritus, nasal congestion) popular, xyzal, levocetirizine
long acting neuraxial peri-prostatic block in cancer

Conditions: Prostate Cancer

Summary: disease progression after definitive therapy for prostate cancer is a major source of morbidity and mortality. adrenergic/sympathetic innervation of the prostate is essential for prostate cancer progression, and abrogation of these signals by blocking adrenergic innervation halts disease progression. long-acting neuraxial block of the sympathetic nerves that innervate the pelvis with dehydrated alcohol (\>98% ethanol) is a safe and effective tool in the treatment of chronic pelvic pain and cancer- induced pelvic pain. furthermore, ultrasound guided periprostatic neuraxial block at the time of prostate biopsy with short-acting lidocaine is standard of care. herein the research team proposes to administer a long-acting periprostatic neuraxial block with dehydrated alcohol and lidocaine under trans rectal ultrasound guidance in patients with high-risk clinical features for prostate cancer at the time of prostate biopsy.


Eligibility criteria:
inclusion criteria: * psa \>10 * psad \>0.15 * pi-rads 5 lesion on mri * karnofsky performance status \>80 * ability to understand and the willingness to sign a written informed consent. exclusion criteria: * prior or concomitant treatment for prostate cancer, including radiation therapy, focal therapy, cryo therapy, androgen deprivation therapy. * imaging or clinical evidence of metastatic disease. * psa \> 100ng/ml
feasibility and safety of extraperitoneal laparoscopic extended retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract urothelial carcinoma

Conditions: Upper Tract Urothelial Carcinoma

Summary: extended pelvic lymph node dissection in bladder carcinoma provides staging and, in selected patients, a survival beneﬁt. recent studies showed the therapeutic beneﬁt of retroperitoneal lymph node dissection (rplnd) in advanced stage of upper tract urothelial carcinoma (utuc). also laparoscopic extended rplnd is still a technical challenge in urology, considering the high rate of severe complications and difﬁculties in manipulation. in renji hospital, laparoscopic extended rplnd at time of nephroureterectomy was performed via an extraperitoneal approach, avoiding interference with abdominal organs and achieving better exposure.the aim of the present study was to determine the safety and feasibility of performing an extraperitoneal laparoscopic extended rplnd at the time of radical nephroureterectomy (rnu) for utuc in a prospectively collected cohort of patients.

similar to urothelial carcinoma of the bladder (ucb), utuc can follow routes of metastases to involve regional lymph nodes. nodal metastasis is an adverse prognostic indicator and results in poor outcome, irrespective of the use of systemic chemotherapy or radiation. the ' gold standard ' treatment for uut-uc is rnu. extended pelvic lymph node dissection in bladder carcinoma provides staging and, in selected patients, a survival beneﬁt. recent studies showed the therapeutic beneﬁt of rplnd in advanced stage urothelial carcinoma of the upper urinary tract, but there is still a lack of prospective studies. thus, the current guideline recommends lymph node dissection for invasive ucut on the basis of insufﬁcient evidence. but no prospective studies have standardized the ideal extent of rplnd or the optimum number of total lymph nodes that should be removed in patients with uut-uc. also more and more interest has been paid to establish standardized node dissection templates. also laparoscopic extended rplnd is still a technical challenge in urology, considering the high rate of severe complications and difﬁculties in manipulation. in renji hospital, laparoscopic extended rplnd at time of nephroureterectomy was performed via an extraperitoneal approach, avoiding interference with abdominal organs and achieving better exposure. the aim of the present study was to determine the safety and feasibility of performing an extraperitoneal laparoscopic extended rplnd at the time of rnu for utuc in a prospectively collected cohort of patients.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with upper tract urothelial carcinoma * have no distant metastasis * have an ecog 0 to 2 * expected to receive radical nephroureterectomy exclusion criteria: * had no previous abdominal surgeries * contra-indications to laparoscopic surgery (e.g. severe chronic obstructive pulmonary disease) * patients with ct4 disease before surgery

Keywords: lymph node dissection upper tract urothelial carcinoma nephroureterectomy
training load management in three professional tennis players during covid-19 lockdown: a case series study

Conditions: Monitor Training Load

Summary: research describing training load management during covid-19 enforced home training in professional tennis players is lacking. therefore, the main objective of this case series is to describe in detail the training load management and progression of three professional tennis players before, during and after covid-19 pandemic lockdown.

research describing training load management during covid-19 enforced home training in professional tennis players is lacking. therefore, the main objective of this case series is to describe in detail the training load management and progression of three professional tennis players before, during and after covid-19 pandemic lockdown.

Eligibility criteria:
inclusion criteria: * tennis players training in argentina exclusion criteria: -

Keywords: training load tennis covid
photodynamic therapy for oral leukoplakia and erythroleukoplakia

Conditions: Oral Leukoplakia

Summary: photodynamic therapy for oral leukoplakia and erythroleukoplakia

photodynamic therapy for oral leukoplakia and erythroleukoplakia

Eligibility criteria:
inclusion criteria: * patients with leukoplakia or erythroleukoplakia exclusion criteria: * oral cancers

Keywords: leukoplakia erythroleukoplakia photodynamic therapy
a study to examine the human gastrointestinal tract using the confocal endomicroscope

Conditions: Digestive System Diseases

Summary: the goal of the project is to determine whether confocal endomicroscopy can be used to identify and discriminate among dysplastic, neoplastic, and nonneoplastic tissue, as compared with histologic specimens as a reference. the project will evaluate those at risk for or with known barrett's esophagus, and those with known or suspected biliary strictures. it is our hypothesis that we will be able to identify between neoplastic and nonneoplastic tissue.

this study was amended from it's initial design to increase the number of patients to 200. the study was terminated in july 2016 after 106 patients were enrolled and had completed the study.

Eligibility criteria:
inclusion criteria: * patients with long-standing reflux symptoms, undergoing surveillance for barrett's esophagus, or scheduled for endoscopic therapy with esophageal dysplasia * patients undergoing ercp for known or suspected biliary strictures. exclusion criteria: * have a known allergy or have had a prior adverse reaction to fluorescent contrast agents or chromoendoscopy stains * are younger than age 18 or who are mentally or legally incapacitated or unable to give informed consent * are pregnant or breastfeeding * patients with advanced esophageal cancer * acute gastrointestinal bleeding * coagulopathy * impaired renal function

Keywords: confocal, biliary, esophagus
clotting with different dialyzer membranes

Conditions: Kidney Failure

Summary: primary objective: the purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.

this is a prospective observational cohort pilot study of patients under the care of the royal free hospital with chronic kidney disease who have been established on regular thrice weekly haemodiafiltration treatments in a dialysis centre. information on the study will be disseminated to the royal free consultant nephrologists at the dialysis centre with primary responsibility for the individual patient.

Eligibility criteria:
inclusion criteria: * patients age 18 years and older up to 80 years * under the care of the royal free hospital with chronic kidney disease and established on regular thrice weekly haemodiafiltration. * able to provide written informed consent obtained exclusion criteria: * patients scheduled for a kidney transplant * patients taking concomitant systemic anticoagulants * patients with known prothrombotic or bleeding disorders * patients with abnormal platelet counts * patients unable to provide written informed consent * patients not fulfilling inclusion criteria

Keywords: coagulation haemodialysis
endovascular preparation for kidney tranplantation

Conditions: Renal Failure Chronic; Kidney Transplant

Summary: this national study is a feasibility study. it wants to validate all stages of the endovascular preparation of the iliac axis up to the kidney transplant for patients in whom the installation of a tailor-made endoprosthesis was necessary beforehand. these patients are currently at a therapeutic impasse. this strategy of renal transplantation on an iliac artery endoprosthesis could ultimately give them access to the transplant with an improvement in quality of life and survival, for lower costs of care for the hospital and safety. less social than treatment by hemodialysis


Eligibility criteria:
inclusion criteria: 1. patient from 18 to 85 years old (beyond 85 years old, guidance must remain exceptional) 2. patients with chronic renal failure 3. waiting for a kidney transplant 4. who have a vascular contraindication to renal transplantation because of their anatomical constraints. exclusion criteria: 1-all criteria contraindicating kidney transplant other than for arterial anatomical problems: all criteria contraindicating kidney transplant other than for arterial anatomical problems: * a progressive cancer, which is not cured, * an uncontrolled infectious disease, * severe cardiovascular or respiratory disease making general anesthesia impossible, * unstabilized psychiatric disorders or illness, * dementia proven to have progressed after specialist advice * major obesity, with a body mass index greater than 50 kg/m2 * patient refusal 2. patient under curatorship 3. pregnant woman 4. patients for whom it will not be possible to organize regular medical follow-up
new technologies in the management of lumbopelvic pain

Conditions: Low Back Pain; Rehabilitation; Exercise

Summary: lumbopelvic pain represents one of the leading causes of disability and pain in the world population. it is estimated that 84% of the world's population will suffer from lumbar pelvic pain in their lifetime. this high prevalence causes it to be classified as a public health problem. traditional primary care measures have failed to reduce the prevalence, recurrences and costs of this pathology. in the search for treatments focused on reducing public spending, the concept of tele-rehabilitation appears. it is a tool, via telematics, that provides knowledge on rehabilitation and education in neurobiology of pain, demonstrated in cardiovascular and respiratory diseases. it has been suggested that the use of this instrument could help improve the patient's quality of life at the biopsychosocial level.


Eligibility criteria:
inclusion criteria: * age between 18-65 years. * non-specific low back pain less than 12 weeks of evolution. * knowledge of new information and communication technologies. * internet access. exclusion criteria: * inflammatory pathologies of the locomotor system. * infectious processes. * oncological processes. * neurodegenerative diseases. * pain with neuropathic characteristics. * fractures. * lack of fluency in spanish.