Kornimate/medical-research-clean huggingface dataset:
creation and characterization of two groups of subjects to evaluate sensitivity

Conditions: Sensitivity

Summary: there are few data on elderly people concerning mechanisms involved in the in vivo release and perception of aromatic compounds. any knowledge on this point would be of great interest to the scientific community. concerning the dimensions of sensory perception and in-mouth comfort, there is, to our knowledge, no methodology to describe them. these dimensions are truly original and innovative, and investigating them will lead to the development of foods adapted to elderly populations with chewing and salivation disorders. the expected results are: * to obtain two groups of subjects with differences in chewing abilities and saliva production * the characterization of flavour release profiles in elderly subjects with regard to oral physiology (mastication and salivation) and saliva composition * a sensory profile describing in-mouth comfort when food is eaten


Eligibility criteria:
inclusion criteria: * persons who have provided written consent * age \>= 65 years * persons living at home or in an old-people's home (etablissement hébergement personnes agées dépendantes : ehpad) * persons able to move around independently exclusion criteria: * persons without national health insurance cover * persons in hospital * persons whose mmse (mini-mental state examination) is \< 24 * persons requiring enteral or parenteral feeding * persons who in the last 12 months have received € 4500 by participating in clinical studies, including the present study * persons in a period of exclusion following a previous study * food allergies * adults under guardianship
effects of intervention on hope, anxiety, and attitudes and behavioral intentions of advance care planning in older adults with cancer

Conditions: Advance Care Planning

Summary: the study aims to explore the impact of advance care planning on the attitudes, behavioral intentions, hopes, and anxiety of elderly people with cancer on advance care planning with the assistance of the "advance care consultation for the elderly" manual.

the experimental group used the cartoon version of the "advance care consultation for the elderly" manual to guide the acp process. the process included three parts: an introduction to acp, an introduction to terminal medical care, and a discussion of what the participants wanted to do about their own health in the past, present, and future required medical care. the estimated time to lead and conduct the acp conversation is approximately 40 minutes. the control group maintained routine care. the measurement tools are the advance care planning attitude scale, behavioral intention scale, chinese version of situational anxiety inventory-situational anxiety inventory (stai-s), and hope state inventory (herth hope index, hhi) ). there are three measurement time points: pre-test, two weeks after intervention, and one month after intervention. expected research results: it is expected that intervention measures can improve the positive attitudes and behavioral intentions of elderly people with cancer towards acp while maintaining their sense of hope without increasing anxiety. it is hoped that the intervention of acp can enhance the exploration of their own medical preferences and values by the elderly with cancer, and help them become more aware of their own choices and needs when facing treatment decisions in the future.

Eligibility criteria:
inclusion criteria: 1. cancer patients aged 65 years or older. 2. patients currently undergoing cancer treatment. 3. clear consciousness and able to communicate in mandarin or taiwanese. 4. score of 8 points or higher (inclusive) on the short portable mental state questionnaire (spmsq). exclusion criteria: 1. individuals with a score of 7 points or lower (inclusive) on the short portable mental state questionnaire (spmsq). 2. individuals who have not been informed about their cancer diagnosis.
feasibility and safety of iv sotalol administered as a loading dose to initiate oral sotalol therapy

Conditions: Arrhythmias, Cardiac; Atrial Fibrillation

Summary: the purpose of this study is to evaluate the safety and feasibility of the iv loading strategy in patients who are selected to receive sotalol.

this is an open-label single arm study investigating the safety and feasibility of an intravenous loading regimen of sotalol to initiate patients on oral sotalol therapy. informed consent will be obtained from all patients prior to enrollment in the study. patients will be admitted to the hospital in accordance with standard hospital protocol for oral sotalol loading.

Eligibility criteria:
inclusion criteria: * male and female between 18 - 85 years old * recent (within 1 day) cardioversion for atrial fibrillation with scheduled sotalol therapy * history of highly symptomatic atrial fibrillation who are scheduled for sotalol therapy * creatinine clearance ≥60 ml/min * subject has provided informed consent prior to initiation of any study-specific activities/procedures exclusion criteria: * baseline bradycardia (\<50 bpm) off all antiarrhythmic drugs and or atrioventricular nodal blocking drugs * sick sinus syndrome, unless a functioning pacemaker is present. * any known sensitivities to beta-blockers * uncontrolled heart failure * second-degree (mobitz ii, wenckebach) or third-degree atrioventricular block * recent (within 7 days) surgical or catheter ablation procedure * severe electrolyte abnormalities (including serum k\<3.5) * known use of other qtc prolonging drugs (see appendix a) * recent (within 7 days) sotalol use * baseline qtc \>450 ms * severe reactive airway disease - defined as difficulty breathing from bronchial tubes, swelling and overreaction to an irritant * history of torsade de pointes (tdp) * pregnancy or breastfeeding * left ventricular ejection fraction (lvef) less than 35%

Keywords: sotalol, intravenous, oral, arrhythmias, atrial fibrillation
pyroptosis and ferroptosis in the pathophysiology of lymphedema

Conditions: Lymphedema

Summary: the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

this project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. the study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Eligibility criteria:
inclusion criteria: * control group: patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc. * experimental group: patients who have lymphedema and undergone lymphedema surgery. exclusion criteria: * 1. individuals with venous thrombosis, chronic heart failure, and renal failure. * 2. vulnerable populations, individuals with limited mobility, pregnant women, and minors. * 3. those expected to be unable to attend follow-up visits or complete the study smoothly. * 4. participants who express doubts about the trial and cannot provide satisfactory answers.
the efficacy and safety of traditional chinese medicine (tcm) to the patient with dizziness in emergency department

Conditions: Dizziness

Summary: the study is aimed in patients with persistent dizziness as the chief complaint that is treated with acupuncture or/and far-infrared heat-patch attachment intervention over the acupoints for the purpose of dizziness symptoms treatment. the research hypothesis is that the treatment over acupoints in traditional chinese medicine is effective in treating symptoms of dizziness.


Eligibility criteria:
inclusion criteria: 1. patients with age between 20 to 80-year-old who can cooperate to the whole treatment, testing and questionnaire. 2. the chief complaint is dizziness which diagnosed by the doctor in charge of the emergency department, in together to exclude the patients with severe unstable vital signs, and then consult for help with chinese medicine. 3. sign the clinical trial agreement sheet. exclusion criteria: 1. inacceptable to the research content 2. unable to complete the study process 3. unwilling to cooperate with acupuncture and other treatments 4. abnormal blood clotting profile 5. with wound or allergy over the treated acupoint 6. unstable vital sign 7. post major trauma
incidence, characterisation and outcome-relevance of perioperative sglt2 inhibitor associated ketoacidosis

Conditions: SGLT2 Inhibitor; Ketoacidosis, Eugylcemic

Summary: the goal of this observational study is to generate data on the incidence and outcome-relevance of sodium-glucose cotransporter 2 (sglt2) inhibitor associated ketoacidosis in adult patients with regular intake of any sglt2 inhibitor within the last three months that are undergoing in-patient surgery. further, it will describe strategies in current clinical practice to prevent and manage sglt2 inhibitor associated ketoacidosis. the specific aims of this study are: 1. to assess the incidence of sglt2 inhibitor associated ketoacidosis in surgical patients 2. to characterise fasting times in patients with sglt2 inhibitor associated ketoacidosis 3. to describe the management of sglt2 inhibitor associated ketoacidosis in current clinical practice 4. to assess the outcome impact of sglt2 inhibitor associated ketoacidosis


Eligibility criteria:
inclusion criteria: * prescription and regular intakte of any sglt2 inhibitor within the last three months (regardless if sglt2 inhibitor was discontinued preoperatively or not) * surgical procedure * at least one overnight stay in the hospital following surgery * age \>= 18 years exclusion criteria: * unwilling and/or unable to consent * outpatient surgery
effect of bronchial thermoplasty on moderate bronchial asthma in china

Conditions: Moderate Asthma

Summary: this study aims to investigate the efficacy and safety of bronchial thermoplasty on moderate bronchial asthma in china, by observing the improvement of quality of life, the decrease of acute attack and emergence, as well as the incidence of related complications.

this is a multi-center, open-label and single arm study. at least 50 patients with moderate asthma receive bronchial thermoplasty for three times. asthma quality of life questionnaire (aqlq), asthma control questionnaire (acq), frequency of mild asthma acute attack, pef, fev1, emergency and hospitalization are compared between before and after bt treatment. the unified peak flow test meter will be provided to all subjects enrolled in this study. they will get a follow-up diary book before leaving hospital. in order to ensure the efficiency, all enrolled asthma patients are trained and tested by doctors and nurses from in-patient or out-patient department when they follow up, including how to use the pef meter, how to read and record the data. as for the dosage of medication, all the medication uses are followed the doctor's advice, once the rescue medications were used, the times and dosages are mandatory to be recorded in the diary book by the patients themselves.

Eligibility criteria:
inclusion criteria: 1. age between 18y and 65y. 2. no improvement after ics and laba treatment in patients with moderate asthma 3. have not received bt before 4. stable more than 6 weeks before enrolled in this study 5. no implantable electrical device (e.g. cardiac pacemaker) 6. no permanent anticoagulant is being used exclusion criteria: 1. smoking and have obvious emphysema 2. chest ct showed lower lobe bronchial stenosis or distal complete atelectasis 3. fev1 \< 65% predicted value after using bronchodilator 4. airway infection(within 6 weeks) 5. any circumstances as the following within the past 1 year: lower respiratory tract infection (lrti) for 4 times or above; hospitalization due to respiratory diseases for more than 3 times; increase the dosage of oral corticosteroids due to asthma exacerbation for more than 4 times 6. received endotracheal intubation or icu admission due to asthma attack within the past 2 years 7. concomitant allergic bronchopulmonary aspergillosis 8. implantable electronic devices (such as cardiac pacemaker)/nyha class iv and/or acute myocardial infarction within the past 3 months 9. coagulation disorders,cannot stop taking anticoagulant、antiplatelet drugs or nonsteroidal anti-inflammatory drugs 10. increasing the risk of adverse reactions during bronchoscopy or anesthesia as the followings: pregnancy, insulin-dependent diabetes, epilepsy, or the other severe complications, such as uncontrolled coronary heart disease, acute or chronic renal failure or uncontrolled hypertension 11. others:vocal cord dysfunction、chronic nasosinusitis、airway obstruction or uncontrolled obstructive sleep apnea syndrome

Keywords: bronchial thermoplasty moderate asthma china
analysis of microalbuminuria and markers of inflammation and oxidative stress in adolescents of different ethnic backgrounds

Conditions: Inflammation

Summary: the purpose of this study is to determine if there are signs of inflammation in one's blood and urine and to find out if one's body size or ethnicity has an effect on these substances.


Eligibility criteria:
inclusion criteria: * adolescents between 12 to 18 years old * hispanic, african american or caucasian ethnicity * have a body mass index (bmi) between the 5th and 85th percentile or greater than the 95th percentile * must currently be attending a uc davis pediatric clinic exclusion criteria: * chronic liver or kidney disease, known diabetes or other chronic illnesses (such as sickle cell disease or cystic fibrosis) * subjects can not be acutely febrile, smoke, chronically use prescription medications or oral contraceptive pills.

Keywords: inflammation oxidative stress microalbuminuria
effects of fenofibrate on adipocytokine levels in hypertriglyceridemic patients

Conditions: Hypertriglyceridemia

Summary: fenofibrate increases adiponectin levels, but reduces leptin levels


Eligibility criteria:
inclusion criteria: * hypertriglyceridemia exclusion criteria: * chronic liver disease

Keywords: adipocytokines insulin sensitivity hypertriglyceridemic patients
pembrolizumab in small cell carcinoma of ovary - hypercalcemic type patient

Conditions: Small Cell Carcinoma, Hypercalcaemic Type; Ovarian Cancer

Summary: this is a study of pembrolizumab as consolidation therapy for a patient with small cell carcinoma of the ovary, hypercalcemic type (sccoht).

it is an open-label single patient clinical trial to be conducted at princess margaret cancer centre for a patient with small cell carcinoma of ovary - hypercalcemic type (sccoht) who has rare and aggressive malignancy with no current consensus on treatment approach and surveillance.

Eligibility criteria:
inclusion criteria: * patient with small cell carcinoma of the ovary, hypercalcemic type (sccoht) exclusion criteria: * n/a
peptide-specific vaccination in hla-a*02 positive patients with biochemical recurrence after radical prostatectomy

Conditions: Recurrent Prostate Cancer

Summary: the study evaluates the prostate-specific antigen (psa) response in hla-a\*02 positive patients with biochemical recurrence after radical prostatectomy treated with a prostate-specific peptide vaccine in combination with different immune-adjuvants.

patients with a biochemical recurrence after initial therapy can be included.

Eligibility criteria:
inclusion criteria: * biochemical recurrence after radical prostatectomy * no clinical metastases in ct or bone scan * hla-type: hla-a\*02 positive * karnofsky-performance-index \>70 * age \>45 / \<80 years * no prior or ongoing hormonal therapy * no ongoing radiation therapy * serum-creatinine \<2mg/dl; bilirubin: \<2gm/dl * no history of allergy or chronic obstructive lung disease (cold) exclusion criteria: * patients unable to consent * karnofsky-performance-index \<70 * known allergy or cold * presence of secondary malignancy * prior or ongoing hormonal treatment * ongoing radiotherapy * immunosuppressive medication * seizure
the effect of cognitive dual task and mental fatigue on landing biomechanics

Conditions: Landing Biomechanics; Fatigue

Summary: in this study, three-dimensional biomechanics , by means of lower limb joint angles and moments (opto-electronic system with synchronised force plate), of landing tasks (anticipated, unanticipated and cognitive dual task) before and after a mental fatigue protocol will be compared in a population of basketball, handball and volleyball players.

in this study, three-dimensional biomechanics , by means of lower limb joint angles and moments (opto-electronic system with synchronised force plate), of landing tasks (anticipated, unanticipated and cognitive dual task) before and after a mental fatigue protocol will be compared in a population of basketball, handball and volleyball players.

Eligibility criteria:
inclusion criteria: * volleyball, basketball of handball players * male exclusion criteria: * history or surgery of the lower extremities * history of fractures of the lower extremities

Keywords: landing biomechanics fatigue dual task
bilateral lateral ofc rtms in obsessive compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: according to the literature the lateral part of the orbito frontal cortex (lofc) is a relevant bilateral target for repetitive trans-cranial magnetic stimulation (rtms) in obsessive compulsive disorder (ocd). both hemispheres are concerned in terms of target.


Eligibility criteria:
inclusion criteria: * age: participants will be both males and females, 18-65 years of age included. * diagnosis of ocd * all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks * affiliation to a social security system (recipient or assignee), * signed written inform consent form exclusion criteria: * the exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness * in accordance with the safety criteria for rtms, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded * the patients won't be allowed to change their medication during the trial. the treatment must be stable at least 3 week before day 0. * female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing, * patient under curators * patient hospitalized under duress * patient unable to give his or hers informed consent

Keywords: rtms d-b80 a/p
preliminary investigation of β-hydroxybutyrate supplementation in colorectal cancer prevention

Conditions: Colorectal Cancer

Summary: the aim of this study is to assess the feasibility of beta-hydroxybutyrate (bhb) supplementation in individuals who are undergoing a standard-of-care colonoscopy or flexible sigmoidoscopy.

the aim of this study is to assess the feasibility of β-hydroxybutyrate (bhb) supplementation in individuals who are undergoing a standard-of-care colonoscopy or flexible sigmoidoscopy in order to determine whether bhb supplementation is safe and tolerable. additionally, this study will determine whether bhb supplementations increases serum bhb levels, and leads to transcription and protein expression changes in the colonic mucosa. bhb supplementation will be performed through oral administration of hvmn ketone-iq, a commercially available bhb supplement, with an active ingredient of r-1,3-butanediol, which gets converted to bhb.

Eligibility criteria:
inclusion criteria: * age of 18 years or older * scheduled for a colonoscopy or flexible sigmoidoscopy as part of the patient's standard care * can provide informed consent exclusion criteria: * subject is pregnant, a prisoner, or is under 18 years of age * patient is not able to undergo colonoscopy or flexible sigmoidoscopy * prior total proctocolectomy * history of inflammatory bowel disease * history of diabetes mellitus and are currently on medical diabetes therapy * history of chronic kidney disease with an egfr \< 60 ml/min/1.73m2 * cancer diagnosis where the subject is receiving active therapy * use of either a ketogenic diet or intermittent fasting (defined as a fasting period of 16 hours or more per day that is not associated with a medical procedure) during the 4 weeks prior to enrollment
effect of lower limb constraint induced movement therapy using a torque-assisted exoskeletal wearable device

Conditions: Chronic Stroke; Subacute Stroke

Summary: the aim of this study was to investigate the effects of lower limb constraint induced motor therapy using the robotic rehabilitation device on ambulatory function in chronic stroke patients.


Eligibility criteria:
inclusion criteria: * adults aged 19 years or older * patients with hemiparesis due to ischemic or hemorrhagic stroke * patients in the late subacute or chronic phase, at least 3 months after the onset of stroke * individuals who can independently walk with a functional ambulatory category score of 3 or higher * patients who are able to use torque-assisted exoskeletal wearable device height: 140 cm to 190 cm weight: 80 kg or less shoe size: 230 mm to 290 mm * patients who were independent walkers and had no difficulties performing activities of daily living (mrs ≤ 1) exclusion criteria: * patients with severe cognitive impairment (mmse \<10) or significant communication difficulties such as speech disorders * patients with spasticity in one-sided lower limbs, rated 2 or higher on the modified ashworth scale (mas) * patients with severe musculoskeletal disorders of the lower limbs * patients with contractures that limit the range of motion in the lower limbs * patients with an apparent leg length discrepancy of 2 cm or more * patients with fractures, open trauma, or non-healing ulcers in the lower limbs * patients with serious internal diseases such as cardiovascular disease or pulmonary disease that make it difficult to use exoskeletal wearable device for walking therapy * patients with a history of osteoporotic fractures * patients with other neurological disorders affecting walking (e.g., parkinson's disease, multiple sclerosis, etc.) * any other cases where the investigator determines that participation in this study is inappropriate
a study of bonviva (ibandronate) once monthly in post-menopausal women with osteopenia.

Conditions: Post-Menopausal Osteopenia

Summary: this 2 arm study will compare the effect of oral bonviva (150mg, monthly) and placebo on parameters of bone micro-architecture, assessed by ct scan, bone turnover and bone mineral density. patients will be randomized to receive either bonviva 150mg po or placebo monthly, and measurements will be taken at baseline, and at intervals over 2 years. the anticipated time on study treatment is 2+ years, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * post-menopausal women, aged 55-75 years; * diagnosed osteopenia. exclusion criteria: * history of osteoporotic vertebral fracture; * contraindication to ibandronate.