Kornimate/medical-research-clean huggingface dataset:
a predictive scheme for poor responders in ivf cycles

Conditions: Infertility

Summary: while practicing the different assisted reproductive techniques, the investigators are faced daily by the problem of poor responder females, and the debate about predicting its results based on the outcome of the different orts used. due to the cost of amh as an indicator for ovarian response, the need to re-assess its role was essential in our community, which led us to conduct this prospective multi-center ivf study.


Eligibility criteria:
inclusion criteria: * normal body mass index (bmi) * amh from 0.5-1.1 ng/ml. * previous history of ≤3 oocytes retrieved using conventional long stimulation protocol exclusion criteria: * females suffering from other causes of infertility as tubal, uterine factors or known cases of endometriosis * severe cases of male factor as azospermia * females who were unable or not willing to participate in the study were excluded from the study.
comparison of the efficacy and safety of t2750 and vismed® in the treatment of moderate to severe dry eye syndrome

Conditions: Dry Eye Syndromes

Summary: comparison of the efficacy and safety of t2750 and vismed® in the treatment of moderate to severe dry eye syndrome


Eligibility criteria:
inclusion criteria: * signed and dated informed consent * male or female aged from ≥ 18 years old. * known dry eye syndrome requiring artificial tears within the last 3 months prior to study selection. exclusion criteria: * best far corrected visual acuity \< 1/10 * severe blepharitis * severe dry eye * eyelid malposition * known hypersensitivity to one of the components of the study medications or test products. * pregnant or breast-feeding woman. * woman of childbearing age (neither menopausal, nor hysterectomised, nor sterilized) not using effective contraception (oral contraceptives, intra-uterine device, contraceptive implant or condoms). * inability of patient to understand the study procedures and thus inability to give informed consent. * non compliant patient (e.g. not willing to attend the follow-up visits, way of life interfering with compliance). * already included once in this study. * patient under guardianship.
comparison between 5-aminolevulinic acid photodynamic therapy versus cryotherapy for actinic keratosis treatment

Conditions: Actinic Keratosis

Summary: this study aims to compare in a prospective and randomized way actinic keratosis treatment with 5-aminolevulinic acid photodynamic therapy versus cryotherapy, from the standpoint of therapeutic efficacy, pain, and cosmetic results.

actinic keratosis is a skin lesion induced by chronic sun exposure with a significant prevalence and malignant potential for squamous cell carcinoma, which makes essential its treatment. today there are several possible therapies, where cryotherapy is usually applied in our practice. photodynamic therapy (pdt)is another method also widespread for keratosis which involves the administration of a topical precursor drug which produces endogenous photosensitising substances activated by specific light, selectively destroying the diseased tissue. this study aims to evaluate the use the drug formulation for photodynamic therapy 5-aminolevulinic acid (5-ala) associated with dimethyl sulfoxide, comparing its efficacy with conventional cryotherapy, and also pain and cosmetic results. this project enrolled 137 outpatients from the department of cutaneous oncology of barretos cancer hospital - pio xii foundation, with symmetrical and comparable keratosis in their upper limbs. with the same patient as controls, side arm and therapy to be used were randomized: cryotherapy or photodynamic therapy. for cryotherapy was utilized bottles of liquid nitrogen (cry-ac, 500ml); and for photodynamic therapy was utilized incoherent red light lamp with a total dosis of 37j/cm² . there was one or two sessions of each therapy , at 0 and 3 months; and three assessments for evaluation were done at 0, 3 and 6 months of onset. the evaluations on efficacy were in terms of area regression, and classified as complete response or no response. pain was assessed by visual analogue scale, and numerical scale. cosmesis was evaluated with the presence or not, objectively, of hyper, hypopigmentation or scar retraction. finally, patient's preference regarding utilized therapeutics was noted by the researcher.

Eligibility criteria:
inclusion criteria: * patients older than 18 years. * patients with actinic keratoses "symmetrical", ie, comparable in the upper limbs ( with the same grade, i, ii or iii). * patients in accordance with informed consent. exclusion criteria: * patients with concomitant skin diseases, congenital or acquired (albinism, vitiligo, xeroderma, gorlin, etc.) * immunosuppression (hiv, transplanted patients, etc.) * pregnancy or lactation * patients who do not agree with the informed consent initially or during the protocol. * presence of pigmented lesions near the keratoses. * patients with porphyria. * patients who have undergone less than 2 months with some kind of treatment for keratosis in the upper limbs.

Keywords: actinic keratosis photodynamic therapy 5-aminolevulinic acid cryotherapy
infinity™ with adaptis™ technology study

Conditions: Arthritis, Rheumatoid

Summary: infinity™ with adaptis™ technology total ankle replacement follow-up (itar2) - prospective, multi-site, multi-year post-market clinical follow-up study study group primary/unilateral and/or bilateral total ankle arthroplasty subjects implanted with infinity™ total ankle system number of subjects 200 patients with up to 13 sites

the selected design is a multi-center, non-randomized, prospective study of 200 subjects in the us with up to 13 investigational sites and a potential for more as needed to meet the enrollment requirements. the study subjects included are those with ankle joints damaged by severe rheumatoid arthritis, post-traumatic disease, and degenerative arthritis and implanted with the infinity™ with adaptis™ technology total ankle system.

Eligibility criteria:
inclusion criteria: * be over 22 years of age at the time of surgery; * diagnosed with unilateral and/or bilateral ankle joint disease; * diagnosed with ankle joint damage from rheumatoid arthritis, post-traumatic, or degenerative arthritis; * willing and able to consent to participate (written, informed consent; * willing and able to attend the requested follow-up visits; * a clinical decision has been made to use infinity™ with adaptis™ technology total ankle system replacement prior to enrollment. exclusion criteria: * subjects with an ankle condition, as determined by the investigator, to be an inappropriate candidate for a total ankle replacement; * subjects requiring revision total ankle replacement of the ankle being considered for study
sonographic signs of gouty arthritis in a cohort of egyptian patients: a cross sectional multicenter study

Conditions: Sonographic Signs of Gouty Arthritis in Diagnosed and Suspected Patients

Summary: the study is a cross sectional observational multicenter study. it is established in collaboration with the egyptian college of rheumatology study group (ecrsg). it is conditioned that all the study participants had either mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal (mtp) joint in patients with a known history of gout or at high risk. patients with any known chronic arthritis, comprising rheumatoid arthritis, sjogren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy, will be excluded from the study. none of the participants had a history of intra-articular injection or aspiration in the scanned joints for 3 months prior to the inclusion in the study. the sonographers will be blinded for clinical data and the eular scanning protocol for the knee and 1st mtp will be considered \[2\]. further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. all the sonographers in the study had an experience between 5 and 10 years in the field of musculoskeletal ultrasound.


Eligibility criteria:
inclusion criteria: * mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal * patients with a known history of gout or at high risk exclusion criteria: * patients with any known chronic arthritis, comprising rheumatoid arthritis, sjoegren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy * history of intra-articular injection in the last 3 months.
evaluation of diamel® combined with insulin in diabetic foot ulcer

Conditions: Diabetic Foot Ulcer; Diabetic Foot; Diabetes Mellitus, Type 2

Summary: diabetic foot syndrome is one of the most frequent complications in type 2 diabetic patients. the present work is carried out with the objective of evaluating the use of diamel combined with insulin in diabetic foot ulcers. method. phase ii clinical trial. a study group was created that receives the active product and another control group that receives a placebo. double-blind study with a monthly follow-up for the first 6 months and then quarterly until the end of 1 year. complementary tests are performed every 6 months to evaluate metabolic, lipid and renal function control.


Eligibility criteria:
inclusion criteria: * homeostasis model assessment (homa) estimates steady state beta cell function (% b) and insulin sensitivity (% s), as percentages of a normal reference population exclusion criteria: * manifestation of hypersensitivity to any component of the product * uncooperative patients * severe infection * debilitating diseases * steroid treatment * pregnancy

Keywords: diabetes insulin diabetic foot nutritional supplement diamel
a self-administered maneuver to relieve symptoms suggestive of benign prostatic hyperplasia

Conditions: Benign Prostatic Hyperplasia

Summary: the objective of this study was to evaluate the effectiveness of the digital repetitive infrapubic pressure maneuver, a self-administered procedure used to provide symptomatic relief in initiating and maintaining urine flow impeded by benign prostatic hyperplasia.

eligible patients were alternately assigned to either immediate instruction on the use of the digital repetitive infrapubic pressure maneuver (immediate intervention group) or to a return appointment to receive instructions in the maneuver four weeks after the initial assessment date (delayed intervention group). patients were to utilize the procedure on every occasion they had difficulty initiating, maintaining, or completing urine flow between the time of their instruction and their subsequent visit. at the initial assessment visits and the final visit, the patients completed an international prostate score sheet (ipss). a telephone survey was conducted with all patients an average of nine months following their instruction in the maneuver, to determine the extent to which they were still using it.

Eligibility criteria:
inclusion criteria: * mild to moderate symptoms of difficulty initiating and maintaining the flow of urine * not currently receiving treatment for the condition * not taking an alpha-blocker at least one month before randomization * not taking 5-alpha reductase inhibitor six months or more before randomization. exclusion criteria: * non-ambulatory * taking medications known to affect urination, * any of the following: a debilitating concomitant illness, a history of prostate or bladder cancer or prostate surgery or radiation treatment to the pelvis, urethral stricture, neurogenic bladder, current urinary tract infection or otherwise potentially compromised urinary tract systems, a creatinine level of over 3.0 mg per deciliter, or a residual urinary volume after voiding of over 350 cubic centimeters.

Keywords: benign prostatic hyperplasia bph lower urinary tract symptoms luts self-administered maneuver symptomatic relief digital repetitive infrapubic pressure maneuver
holiday season weight change during islamic holidays

Conditions: Body Weight Changes

Summary: the study involved 30 regular exercisers and 33 non-exercisers. food records were collected five times: before the holiday season, before ramadan, during ramadan, during ramadan feast, and after ramadan feast, including the eid al-adha period. anthropometric measurements were taken before and after holidays: initially before ramadan and again after eid al-adha. physical activity was recorded for both groups: once before ramadan for non-exercisers and twice (on exercise and rest days) for exercisers.

the purpose of this study is to determine the changes in nutrient consumption during the holiday season and to assess the changes in body weight, body composition, and blood pressure of exercising and non-exercising individuals at the end of this season. in the united states of america, the holiday season is the period between thanksgiving and new year's day. in turkey, the holiday season is defined as the period between the feast of ramadan and the feast of sacrifice. a total of 30 individuals who regularly exercise and 33 who do not exercise participated in the study. in this study, 3-day food consumption records were taken from the participants five times; before the holiday season, before ramadan, during ramadan, during ramadan feast, after ramadan feast, and during the eid al-adha period. the anthropometric measurements of the participants were measured before and after the holidays. the first measurement was taken before ramadan, and the second was taken after eid al-adha. physical activity was recorded in the pre-ramadan period, once for non-exercising participants, and twice for exercising participants, on exercise and rest days.

Eligibility criteria:
inclusion criteria: * age between 20 to 45 years * body mass index (bmi) between 18.5-40.0kg/m2 * observing the islamic holiday season. exclusion criteria: * pregnant or lactating women * chronic metabolic diseases including type 1 or type 2 diabetes, any type of cancer, cardiovascular diseases * 5kg of weight gain or loss in the last 3 months * planning to lose weight or following a specific diet * exercising \>300min/week * medication use that might affect body weight or composition

Keywords: holiday weight gain fasting body composition
impact of early mobilization on mechanical ventilation duration in intubated critically ill patients

Conditions: ICU Acquired Weakness

Summary: the purpose of the present study is to compare usual care in terms of mobilization performed to intubated icu patients to a standardized program designed to deliver early mobilization at least 5 days a week. this study has a before / after design with a control group during the experimental phase. the first phase of the study corresponds to an observational phase during which every act of mobilization performed to the included patients is going to be documented. during this first study period, total duration of mechanical ventilation is going to be recorded for all the patients included. at the end of this first study period, the participating icu are going to be randomized (cluster randomization) in two groups either observational or experimental. the corresponding strategy is going to be applied to all the patients included during the second study period. during this second period, total duration of mechanical ventilation is also going to be recorded for all the patients included. the study hypothesis is that applying a protocolized early mobilization strategy increases the number of ventilator free-days during the 28 days after intubation in icu patients.


Eligibility criteria:
inclusion criteria: * admission in intensive care unit * invasive ventilation for more than 24 hours * invasive ventilation for less than 48 hours * expected duration of invasive ventilation of more than 24 hours at the time of inclusion. exclusion criteria: * pregnancy * failure to obtain a consent from someone authorized * patient under law protection. * patient non-affiliated to a health care system. * active therapeutic limitation * hospitalisation for more than 7 days before intubation * admission in intensive care unit after a surgical procedure, burn or trauma * admission in intensive care unit because of neurological disease * previously known neuromuscular disease * bilateral lower limbs amputation * bmi above 40 kg/m² * limitation in daily activities before icu admission * chronic ventilation (more than 12h /24 hours) on tracheotomy before icu admission * participation in another interventional clinical study related to mobilization or in an interventional clinical study which has mechanical ventilation duration as primary outcome * previous enrolment in the same phase of the earlymob study

Keywords: early mobilisation invasive ventilation ventilator free days intensive care unit
a study comparing the efficacy and safety of idp-121 and idp-121 vehicle lotion in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the primary objective of this study is to compare the efficacy, safety and tolerability of idp-121 lotion and vehicle in the treatment of subjects with acne vulgaris.

this is a multicenter, randomized, double-blind, parallel group, vehicle-controlled, 12-week study to evaluate relative changes in inflammatory and non-inflammatory lesion counts, as well as treatment success using an evaluator's global severity scale (egss) in subjects with moderate to severe acne. idp-121 is a lotion for the topical treatment of acne.

Eligibility criteria:
inclusion criteria: * male or female at least 9 years of age and older * written and verbal informed consent must be obtained. * subject must have a score moderate or severe on the evaluator's global severity assessment at the screening and baseline visit * pre-menses females and women of childbearing potential must have a negative urine pregnancy test at the screening and baseline visits * subjects must be willing to comply with study instructions and return to the clinic for required visits. exclusion criteria: * any dermatological conditions on the face that could interfere with clinical evaluations * any underlying disease(s) or some other dermatological condition of the face that requires the use of interfering topical or systemic therapy or makes evaluations and lesion count inconclusive * subjects with a facial beard or mustache that could interfere with the study assessments * concomitant use of potentially irritating over-the-counter products
cranial electrotherapy stimulation on anesthetics consumption and postoperative pain

Conditions: Opioid Use; Cytokine

Summary: cranial electrotherapy stimulation (ces) is a non-invasive intervention to treat anxiety, depression, insomnia, and pain. but clinical studies and applications of ces in relation to acute postoperative pain are few. tthe investigators investigate a double-blind, randomized controlled trial to figure out if intraoperative ces could decrease dosage of intraoperative anesthetics and patient-controlled analgesia (pca) consumption in patients undergoing colon cancer surgery.

cranial electrotherapy stimulation (ces) is a non-invasive and safe intervention, transmitting microcurrents of brain stimulation and releasing various neurotransmitters such as endorphin and downstream hormones to modulate autonomic nervous system, as a result, for treating anxiety, depression, insomnia, and pain. acute postoperative pain annoys patients receiving surgery. once acute postoperative pain is poorly controlled, it may result in adverse acute effects (i.e., physiologic and psychologic stress), chronic effects (i.e., delayed long-term recovery and chronic pain), and, in consequence, excess length of hospitalization and extra costs. besides, inflammatory reactions mediated by immune system are formed after tissue injury (e.g. trauma, surgery, etc), release serial inflammatory cytokines and are related to pain signal transmission. however, clinical studies and applications of ces focus on management of chronic pain, modulation of mood and insomnia rather than acute postoperative pain in recent years. the investigators investigate a double-blind, randomized controlled trial to figure out if intraoperative ces could decrease dosage of intraoperative anesthetics and patient-controlled analgesia (pca) consumption in patients undergoing colon cancer surgery. the investigators also collect blood samples before and after surgery for analysis of serum cytokines. meanwhile, bispectral indextm (bistm) monitoring and analgesia nociception index (ani) are prescribed during the surgery not only for measuring of the effects of anesthetics and sedatives on the brain, but also evaluating perioperative analgesia. thereby, the effectiveness of ces for management of acute postoperative pain may introduce clinicians for alternative application of pain control after surgery in the future.

Eligibility criteria:
inclusion criteria: * patients undergoing colon cancer surgery exclusion criteria: * presence of an implantable device (e.g., pacemaker) * pregnancy * having a known mental illness (e.g., schizophrenia, mood disorder, bipolar disorder, etc. * cancer of the head and neck or brain tumor or brain metastasis * having delirium

Keywords: cranial electrotherapy stimulation (ces) autonomic nervous system acute postoperative pain colon cancer surgery patient-controlled analgesia (pca)
effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration

Conditions: Age-Related Macular Degeneration

Summary: the macular pigment (mp) in humans consists of the yellow, blue-absorbing carotenoids lutein and zeaxanthin. the highest concentrations of lutein and zeaxanthin are found in the fovea. since light entering the eye passes through the mp before reaching the photo receptors it absorbs a significant portion of short-wavelength light. there is evidence that this absorbing properties of the mp as well as the ability of inactivating highly reactive oxygen species are protective for the retina. age-related macular degeneration is the leading cause of blindness among developed countries. the pathogenesis of this disease remains unknown. there is, however, evidence that low fruit and vegetable consumption increases the risk of age-related macular degeneration (amd). accordingly, it has been hypothesized that lutein supplementation may be beneficial in amd. the present study investigates whether 6 months lutein supplementation increases mp optical density (od), influences visual acuity, depth and dimension of central scotoma and alters symptoms in patients with amd.


Eligibility criteria:
inclusion criteria: * patients with nonexudative amd (either categories 2, 3 or 4 according to the areds criteria; in group 4 the eyes with no-advanced amd will be included, age-related eye disease study research group 2001) * age between 50 and 90 years * clear non-lenticular ocular media * visual acuity \> 0.4 exclusion criteria: * primary retinal pigment epithelium atrophy \> 125 µm * moderate or severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy * participation in a clinical trial in the 3 weeks preceding the study * previous treatment with lutein within 3 month of study initiation * history of hypersensitivity to the trial drug or to drugs with a similar chemical structure * history or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs * ocular surgery within the last 6 months * treatment with photosensitizing drugs

Keywords: lutein nonexudative amd mpod supplementary concepts