Kornimate/medical-research-clean huggingface dataset:
physiologic effects of nasal high flow on exercise tolerance in copd

Conditions: COPD

Summary: this study aims to assess whether to describe the effects of the administration of nasal high flow (nhf) at 70 liters per minute (l/min) in a 6-minute walk test (6-mwt) among chronic obstructive pulmonary disease (copd) patients and to characterize the association between self-reported dyspnea with and without nhf at 70 l/min following a 6-mwt.


Eligibility criteria:
inclusion criteria: * able to consent * age 18 years or older * diagnosis of copd * ability to ambulate without assistance * use of low-flow nasal cannula ≤ 4 l/min or no supplemental oxygen (o2) at all exclusion criteria: * pregnancy * being on bedrest * inability to consent or cooperate with the study * using of \> 4 l/min of supplemental o2 or requiring non-invasive ventilation during the daytime * hemodynamic instability (resting heart rate \> 130/minute, systolic blood pressure of ≤ 90 mmhg or ≥ 180 mmhg) * metal implants in the thoracic regions (pacemakers, automatic implantable cardioverter defibrillator (aicd), plates, screws, rods, and disc replacements)
study of atropine therapeutic effect on myopic progression

Conditions: Myopia; Children

Summary: this study is to evaluate the therapeutic effect and safety of lptat in children with myopia.

the primary objective is to evaluate the superiority of lptat to placebo in slowing myopia progression through the change of se(spherical equivalent), which is measured by cycloplegic autorefraction after 12-month treatment.

Eligibility criteria:
inclusion criteria: * aged 5 to 12 years at the time of consent * refractive error of se at least -1.0 d and no greater than -8.0 d in both eyes as measured by cycloplegic autorefraction at visit 1 and visit 2. * confirmed myopia progression of 0.5d or more within past 1year * astigmatism of 2.5d or less in both eyes * distance best corrective visual acuity to logmar 0.2 or better in both eyes at visit1. * normal iop under 21mmhg in both eyes. * anisometropia of se less than 2.0d as measured by cycloplegic autorefraction at visit 1. * written informed consent willingly obtained by both subject and his/her parents exclusion criteria: * hypersensitivity to atropine or other cycloplegic agent. * history of the surgery of refractive correction * having ocular disease affect to visual function or refractive error: history of glaucoma, macula r degeneration, diabetic eye disease, uveitis, etc, or presence of conjunctivitis at screening visit. * having systemic diseases that affect to vision loss * having risk of iop elevation such as narrow angle, shallow anterior chambers, etc * presence of binocular function disorder or stereopsis disorder * amblyopia or manifest strabismus * history of premature birth(less than 37weeks) or low birth weight(less than 2,500g) * previous or current use of atropine or ortho-k lens for myopia * down syndrome, spastic paralysis, brain damage, spastic palsy, bladder * presence of neurological diseases like epilepsy, etc. which could expect difficulties in compliant to the ocular examinations. * presence of clinically significant cardiac and respiratory diseases * participation in any other clinical study of an investigational product within 3-month prior to current ip administration. * based on the investigator's discretion, subject who is not proper to participate in the trial.
endoscopic resection of gastrointestinal neoplasms

Conditions: Endoscopic Mucosal Resection; Endoscopic Submucosal Dissection; Gastric Neoplasm; Colonic Neoplasms; Esophageal Neoplasms; Duodenal Neoplasms

Summary: the study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare different resection techniques. in particular, the resection techniques investigated will be mucosectomy, en bloc and piecemeal, endoscopic submucosal dissection (esd) and its variants, full-thickness resection. the anatomical districts involved will be the esophagus, stomach, duodenum, colon and rectum.


Eligibility criteria:
inclusion criteria: * 18 years or older * all patients who have undergone endoscopic resection of an upper or lower digestive tract tumor exclusion criteria: * age under 18 * inability to provide informed consent

Keywords: endoscopic mucosal resection (emr) endoscopic submucosal dissection (esd) endoscopic full thickness resection (eftr) colorectal esd colorectal emr
muscle memory after treatment with anabolic substance clenbuterol and resistance training in humans

Conditions: Skeletal Muscle Physiology

Summary: the purpose of the project is investigate muscle memory and underlying mechanisms in humans following resistance training and use of the anabolic substance clenbuterol.


Eligibility criteria:
inclusion criteria: * healthy men and women * bmi of \<26 and normal ecg and blood pressure exclusion criteria: * smoking * chronic disease, * use of prescription medication * pain due to current or previous musculoskeletal injury * resistance training more than once per week in the 12 months leading up to the intervention * current or previous use of prohibited anabolic substances
effects of sleep hygiene education and lavender oil inhalation on sleep quality, fatigue, quality of life

Conditions: Ostomy

Summary: self-care non-pharmacological methods can help reduce the negative health effects of sleep problems or insomnia. this trial aims to investigate the effects of sleep hygiene education and lavender oil inhalation alone and in combination on sleep quality, fatigue, and health-related quality of life in adults with a stoma.

this study has been planned as a randomized controlled clinical trial and will use a 2x2 factor design in which an equal number of participants meeting the inclusion criteria will be randomly allocated to one of four groups. the study population will comprise 120 adult patients who have undergone ostomy surgery in a city hospital in turkey. lavender oil inhalation together with sleep hygiene education will be applied in the first group (n=30), only sleep hygiene education in the second group (n=30), only lavender oil inhalation in the third group (n=30), and no intervention in the fourth group (n=30). the sleep quality of the groups will be evaluated using the pittsburgh sleep quality index, their fatigue levels with the chalder fatigue scale, and their quality of life with the stoma quality of life scale.

Eligibility criteria:
inclusion criteria: * 18 years or older, * at least three months having passed after ostomy, * having a clear level of consciousness and no disease or medication use that can negatively affect the level of consciousness, * being able to communicate in turkish, * providing informed written consent to participate in the study. exclusion criteria: * lavender allergy, * respiratory tract infections such as sinusitis and pneumonia, * body mass index (bmi) of \>40, * a diagnosis of sleep disorder and/or medication use for sleep problems.

Keywords: ostomy sleep hygiene lavander oil sleep fatigue quality of life
effect of hfcwo vests on spirometry measurements

Conditions: Cystic Fibrosis; Bronchiectasis

Summary: the impact of high-frequency chest wall oscillation therapy on spirometry values (forced expiratory volume, forced vital capacity, peak expiratory flow, forced expiratory flow and tidal volume is investigated during use of several products and comparing to baseline values

the study will be broken into one (1) arm: • afflovest® \& monarch™ within the arm, the order of products will be randomized. baseline spirometry (forced expiratory volume (fev1), forced vital capacity (fvc), peak expiratory flow (pef), forced expiratory flow (fef25-75%) and tidal volume (tv)) will be taken at the beginning, middle and end of each series of measurements with each subject, without any device on the subject. a product (afflovest or monarch) will be placed onto subject and turned on to the highest frequency and intensity settings. then the subject will be given a certain period of time to adjust and spirometry measurements will then be repeated, then the product will be removed and the subject will be allowed a recovery period, then the other product will be placed on the subject, turned on and spirometry measurements will repeated.

Eligibility criteria:
inclusion criteria: - healthy subject, ages 18 - 50 exclusion criteria: * non-ambulatory * diagnosed neuromuscular disorder * currently using any type of oscillation vest therapy * diagnosed co-morbid condition (i.e. lung cancer, other lung disorder or disease) * currently enrolled in a medical research study * non-english speaking * presence of the following active implantable devices: pacemakers, neurostimulators, infusion pumps, circulatory support devices, implantable cardioverter defibrillators (icd's), cochlear implants * presence of head and/or neck injury that has not yet been stabilized * presence of active hemorrhage with hemodynamic instability
outcome of patients treated with iabp

Conditions: Acute Coronary Syndrome; Cardiogenic Shock; Coronary Artery Disease; Heart Failure; Left Ventricular Dysfunction; Low Cardiac Output Syndrome; Post-cardiac Surgery

Summary: intra-aortic balloon pumps (iabp) is a widely used and effective left ventricular adjuvant therapy. iabp is an inflatable device placed in the aorta that inflates with diastole and deflates with systole. the aim of this study is to investigate the outcome of patients treated with iabp, and to evaluate the short-term and long-term outcomes of patients with iabp.


Eligibility criteria:
inclusion criteria: * patients receiving iabp for circulatory support exclusion criteria: * refusal of consent
efficacy of apostherapy® in knee oa

Conditions: Osteoarthritis, Knee

Summary: a prospective, interventional, randomized, double-arm clinical evaluation study to examine the efficacy of apostherapy® versus a control group, in the short-term at 6 months and in the long-term at 12 months post-treatment, with the primary efficacy assessment based on improvement in knee pain score and improvement in function in patients following diagnosis of knee osteoarthritis (oa).


Eligibility criteria:
inclusion criteria: * patients suffering from symptomatic unilateral or bilateral knee oa at the medial compartment for at least six months; * fulfilling the acr clinical criteria; * having radiographically assessed oa of the knee with a kellgren-lawrence grade more than or equal to grade 2; and, * having vas-pain ≥ 3, on a scale between 0-10. * patients who have a shoe size between us 4 and us 12 exclusion criteria: * patients suffering from acute septic arthritis. * patients who received a corticosteroid injection within 3 months of the study. * patients who received hyaluronic acid (ha) injections within 6 months of the study * patients suffering from avascular necrosis of the knee. * patients with a history of knee buckling or recent knee injury. * patients who have had a joint replacement or other major surgery to the knee, hip or ankle (ipsilateral or contralateral side). * patients suffering from neuropathic arthropathy. * patients with an increased tendency to fall. * patients exhibiting a lack of physical or mental ability to perform or comply with the study procedure. * patients with a history of pathological osteoporotic fracture. * patients suffering from symptomatic degenerative arthritis in lower limb joints other than the knees. * patients with referred pain in the knees from primary back or hip joint pain. * patients with neurological deficits to the lower extremity (ex. foot drop) * patients whose shoe size is less than us 4 and greater than us 12 * patients who have had arthroscopy within 6 months of the study * patients with inflammatory arthropathy

Keywords: apostherapy® system osteoarthritis total knee arthroplasties degenerative joint disease
glycosylation of exosomes in prostate and urothelial carcinoma

Conditions: Prostate Cancer; Urothelial Carcinoma

Summary: the purpose of this study is to collect a urine sample from patients with prostate and urothelial (bladder) cancer and healthy volunteers who do not have cancer, so that researchers can perform studies on microcellular structures called exosomes that may eventually lead to a new type of urinary biomarker test for prostate and urothelial cancer.

this is a one-time participation, banking study of up to 40 subjects (10 prostate, 10 urothelial, 20 without cancer). subjects must meet eligibility at the time of informed consent and will donate approx. 200ml of urine sample. primary objective: to develop alternative and efficient urinary exosome isolation and glycan analysis approaches for especially large glycan structures, including their isomers present at low levels, which will particularly enhance current analytical technology. to provide further testing of the current microfluidic-based approaches developed to screen glycan samples which this additional specimen will provide to assess whether the current analytical techniques are robust enough to handle this type of sample with sufficient resolution and sensitivity for useful analytical information. to compare alterations in exosome-derived glycans in adults with prostate and urothelial carcinoma in comparison with the exosome-derived glycans in age-matched healthy adults for assessment of findings to explore if the tools could be applied for future study toward a liquid biopsy test.

Eligibility criteria:
inclusion criteria: 1. males ≥ 18 years old at the time of informed consent 2. ability to provide written informed consent and hipaa authorization 3. willingness to donate a fasting urine sample for research patient cohort 1. histologically confirmed prostate or urothelial carcinoma 2. localized disease 3. no neoadjuvant chemotherapy for disease healthy volunteer cohort 1. healthy volunteers must not have prostate or urothelial carcinoma exclusion criteria: 1. concurrent disease or condition that would make the subject inappropriate for study participation or any serious medical or psychiatric disorder that would interfere with the subject's safety 2. dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent

Keywords: glycosylation urinary exosomes exosome-derived glycans
study on the use of inhaled no (ino)

Conditions: Pulmonary Hypertension

Summary: this is a prospective, observational, multicenter study conducted during 1 year in adult and paediatric intensive care units equipped with the ez-kinox™ system. a maximum of 250 patients (newborns to adults, suffering from pulmonary arterial hypertension (pah) associated with cardiac surgery or persistent pulmonary hypertension in the newborn (pphn) receiving ino through the integrated delivery and monitoring ez-kinox™ system was planned to be included. the study is strictly non-interventional with the aim of describing current practices and therefore did not affect the patient usual management.

this study is intended to describe daily practice and therefore, there is not a standardized protocol but only patient-based and site-based questionnaires.

Eligibility criteria:
inclusion criteria: * newborn \> or = to 34 weeks gestational age suffering from hypoxic respiratory failure with pulmonary hypertension (france only) or patient presenting post-operative pulmonary hypertension associated with cardiac surgery (france and belgium) · patient treated with ino delivered with ez-kinox™ exclusion criteria: * newborn dependent on a right-to-left shunt or with a "malignant" left-right arterial canal * newborn with glucose-6-phosphate dehydrogenase (g6pd) deficiency.
effect of wii-console based exercise on shoulder range of motion for post-mastectomy lymphedema patients

Conditions: Postmastectomy Lymphedema

Summary: purpose: to determine the effect of wii-console based exercise on shoulder rom of both sides for post-mastectomy patients, and highlighting the effect of dominancy.

breast cancer has been the focused of many studies because it significantly affects both in developed and developing countries worldwide (cameirão et al, 2008). lymphedema affects the range of motion of shoulder causing disability and affection of function. wii-console systems can be used as training tools to promote intensive training directed towards specific deficits and guide the patients in task-oriented activities. moreover, it allows a real-time high-resolution monitoring, where is possible to have a quantitative assessment of relevant properties of the impairment, performance and recovery. on the other hand, virtual reality environment demand focus and attention of the patient, motivate the patient to perform the exercises, and provide a sense of achievement to the user (torre et al, 2015). hypotheses: the wii-console based exercise will have no effect on shoulder rom for post-mastectomy patients.

Eligibility criteria:
inclusion criteria: * all the patients will be females. * patients undergone mastectomy with lymph nodes dissection. * all developed lymphedema after the surgery. exclusion criteria: * vision problems. * medically instable patients. * balance disorders. * other musculoskeletal condition of shoulders.
litramine for weight loss

Conditions: Weight Loss

Summary: safety and efficacy of litramine in weight loss.


Eligibility criteria:
inclusion criteria: * healthy subjects ≥18 and ≤ 60 years of age * body mass index (bmi) ≥ 25 and ≤35 kg/m2 * judged by the investigator to be in general good health on the basis of medical history * judged by the investigator to be motivated to lose weight * accustomed to 3 main meals per day * consistent and stable body weight 3 months prior to study enrollment (±5%) * consistent regular physical activity * agree to stop all medications and supplements during the entire length of the study * commitment to adhere to diet and lifestyle recommended for the study * females of child bearing potential must agree to use appropriate birth control methods during the entire study period * stable concomitant medications * understands the study procedures and signs forms providing informed consent to participate in the study and authorization for release of relevant protected health information to the study investigator exclusion criteria: * presence of any active gastrointestinal disease * malabsorption disorders * pancreatitis * stenosis in the gi tract * bariatric surgery/lapband and bypass surgery * abdominal surgery within 6 months prior to the study * subjects whose weight increases 1.5 pounds from screening to the baseline visit * history of eating disorders like bulimia, anorexia nervosa, binge-eating * renal conditions / disease, history of nephrolithiasis * cardiac diseases requiring drug therapy * other serious organ or systemic diseases such as diabetes mellitus, standard laundry list of cardiac diseases * osteoporosis or on medications for osteoporosis * known sensitivity to the ingredients of the study medication * vegetarian or vegan * daily use of dietary supplement (2 week washout is allowed) * any medication that could influence gastrointestinal functions such as antibiotics, laxatives, opioids, anticholinergics, or anti-diarrheals (must have stopped at least 3 months before study start) * subjects who are pregnant or lactating * any medication or use of products for the treatment of obesity (e.g., xenical, other fat binder, fat burner, satiety products etc.) * subjects who are currently on carbohydrate and protein diet, or low fat diet * more than 3 hours of strenuous physical activity per week * history of abuse of drugs, alcohol or medication * smoking cessation within the 6 months prior to this study * subjects unable to understand or follow the study protocol * participation in similar study or weight loss program within 6 months prior to this study * participation in other studies with in the last 4 weeks
assessment of depression levels in elderly patients with an orthopedic fracture compared to patients after a stroke.

Conditions: Depression; Old Age; Debility; Stroke; Fractures, Bone

Summary: depression is common among elderly patients hospitalized due to acute conditions like strokes or osteoporotic fractures. it has significant impacts on quality of life, hospitalization rates, and mortality. although studies have explored depression and its assessment, most focus on non-geriatric or ambulatory populations. this study examined depressive symptoms in elderly patients after a stroke or fracture. we assessed all patients for depression symptoms using the validated geriatric depression scale - 15 item (gds-15) and searched for contributing factors in each condition.

depression is a common condition among elderly patients hospitalized due to acute events and has both short-term and long-term prognostic impacts, including reduced quality of life, recurrent hospitalizations, and even mortality. numerous studies have examined the effects of depression and the ability to assess it, but most have been conducted in non-geriatric populations and in ambulatory patients. it remains unclear whether different acute conditions are associated with distinct risk factors for depressive symptoms and whether depressive symptoms may have varying impacts across different acute conditions. in this study, we examined depressive symptoms in two groups of elderly patients-those with stroke and those with osteoporotic fractures. these are two common acute conditions in the geriatric population, both with significant implications for patient function and the incidence of depression. patients were recruited from a large geriatric hospital; all patients were capable of signing consent forms. at the beginning of their hospitalization, all patients will undergo a standardized depression screening test (gds-15), and additional data will be collected from computerized medical records, including baseline data and the functional independence measure (fim) at the beginning and end of rehabilitation. statistical analyses, including univariate analyses and multivariate regression, will be conducted to identify variables associated with depressive symptoms. linear regression models will be constructed for each group based on the variables significantly associated with depression to assess the risk of depression according to the identified risk factors. to evaluate the risk of depression according to the models and assess the predicted gds value's ability to classify participants with or without depression roc curves will be used and auc will be calculated.

Eligibility criteria:
inclusion criteria: * age \> 65 and hospitalization after stroke or fracture exclusion criteria: * prior diagnosis of depression/current antidepressant treatment before hospitalization/ significant cognitive decline as indicated by a mini-mental state examination (mmse) score below 20/lacking the capacity to provide informed consent.