physical activity in older patients with acute myeloid leukemia undergoing chemotherapy

Conditions: Leukemia

Summary: rationale: physical activity sessions may help improve physical function, quality of life, and symptoms caused by chemotherapy in older patients with acute myelogenous leukemia. purpose: this clinical trial is studying how well physical activity works in improving quality of life in older patients with acute myelogenous leukemia undergoing chemotherapy.

objectives: primary * to test the feasibility of conducting a physical activity intervention in hospitalized older adults with acute myeloid leukemia (aml) undergoing induction or reinduction chemotherapy. secondary * to obtain preliminary data regarding the effectiveness of a physical activity intervention on physical function, quality of life, and treatment-related symptoms in these patients. outline: patients undergo a baseline evaluation in week 1 focusing on basic demographics, health, physical function and quality-of-life assessments. these assessments include the short physical performance battery (sppb); the hand grip test of muscular strength; the demographics and physical activity history; the functional assessment of cancer therapy (fact-leu); the distress thermometer; the short-form positive affect schedule (panas-sf); the satisfaction with life scale (swl); the fast-23 disability measure; the center for epidemiologic studies depression scale short form (ces-d); the self-efficacy for physical activity scale; the intervention feedback form; and the pre-post session ratings. some medical data may be obtained from the patient's medical record to assist in these assessments. beginning in weeks 2-5, patients undergo a 30-minute orientation to the exercise sessions that will be tailored to individual needs and abilities. patients undergo a 30- to 45-minute group physical activity session twice a week, and a supervised individual session following the same format as the group session, once a week for 4 weeks. after completion of the physical activity intervention, patients complete an activities packet and repeat the physical function and quality of life assessments in weeks 5-6 and again upon readmission for consolidation therapy in weeks 9-13 . after completion of study intervention, patients are followed for 4 months.

Eligibility criteria:
disease characteristics: * histologically confirmed acute myeloid leukemia (aml) by who criteria * planning to undergo induction or reinduction chemotherapy * inpatient status at wake forest university baptist medical center * must not require intensive care unit support patient characteristics: * able to understand english * medical eligibility confirmed with leukemia service attending * ambulatory or able to walk with a cane * no hemodynamic instability * no acute thrombosis within the past 7 days * no active ischemia within the past 7 days * no uncontrolled pain * must have \< 3 incorrect responses on the pfeiffer mental status exam prior concurrent therapy: * see disease characteristics

Keywords: recurrent adult acute myeloid leukemia adult acute myeloid leukemia with 11q23 (mll) abnormalities adult acute myeloid leukemia with inv(16)(p13;q22) adult acute myeloid leukemia with t(15;17)(q22;q12) adult acute myeloid leukemia with t(16;16)(p13;q22) adult acute myeloid leukemia with t(8;21)(q22;q22)