Kornimate/medical-research-clean huggingface dataset:
the efficacy of automated feedback after internet-based depression screening

Conditions: Depression; Major Depressive Disorder

Summary: the discover randomized controlled trial is designed to evaluate the effect of automated feedback after internet-based depression screening in individuals with undetected depression. a total of 1076 individuals reporting elevated levels of depression (phq-9 score ≥ 10 points) will be randomized into three groups to either receive a) no feedback (control group), b) standardised or c) tailored feedback on their depression screening results.the primary hypothesis is that feedback reduces depression severity six months after screening compared to no feedback. the secondary hypothesis is that tailored feedback is more efficacious as compared to standard feedback.

major depressive disorder (mdd) is a highly prevalent condition associated with substantial disease burden and economic costs. still, it often remains undetected and untreated, which in turn increases the likelihood of a chronic course, treatment resistance and rising healthcare costs. one solution to address early detection and disease burden could be widely accessible depression screening. our previous trial in cardiac patients provides first evidence that depression screening combined with written individual-targeted feedback on the screening results improves depression severity and encourages greater patient participation and engagement in mental health. to amplify these effects in a broader setting, the internet-based discover randomized controlled trial (rct) now aims at addressing affected but yet undetected individuals on the internet. in order to evaluate the effect of feedback in this setting, a total of 1076 individuals reporting elevated levels of depression (phq-9 score ≥ 10) will be randomized into three groups. they either receive a) no feedback (control group), b) standardised or c) tailored feedback on their depression screening results. the primary hypothesis is that feedback reduces depression severity six months after screening compared to no feedback. the secondary hypothesis is that tailored feedback is more efficacious as compared to standard feedback. futher outcomes are guideline-based depression care, depression-related help-seeking behaviour, a health economic evaluation, clinical outcomes (somatic symptom severity and anxiety), health-related quality of life, illness beliefs, intervention acceptance, depression diagnosis and adverse events.

Eligibility criteria:
inclusion criteria: * (gender: male, female, diverse) * age ≥ 18 years; no maximum age * sufficient german language skills * informed consent * patient health questionnaire-9 \> 9 points * contact details * internet access * sufficient computer/internet literacy exclusion criteria: * diagnosis of a depressive disorder within the past 12 months * depression treatment (current or within the past 12 months)

Keywords: depression screening tailored feedback internet-based intervention early detection
healthcare renunciation during the confinement period in connection with the covid-19 epidemic in adult emergency departments

Conditions: Emergency Medicine

Summary: healthcare renunciation is defined as: "individuals give up care when they do not seek services and health care professionals when they experience a disorder, experience a physical or mental disorder, or when they do not access all of the prescribed care." in 2008, 16.5% of the general french population reported having renounced care. the causes mentioned of the renunciation are mainly the financial difficulties, the deadlines of appointments considered too long, the geographical remoteness. in the department of sarthe, the rate of cessation of care is estimated at 27.6% over the period from 2014 to 2017. in the context of the covid-19 epidemic, containment was applied in france counted from 17 march 2020. the widespread message was "save lives, stay at home". the ministry of solidarity and health has provided health professionals with a circular to adapt the management of patients with chronic disease, requiring elective surgical care and pregnant women. the decline in activity of general practitioners is estimated at 44% and that of other specialists at 71%. in paris, visits to the emergency room fell by 45% for adults and 70% for children. the main risk is the deterioration of the health status of some patients with the worsening of chronic diseases, the discovery of pathologies during episodes of decompensation and the absence of management of serious acute pathologies. the study aims to assess the importance of giving up care during this period of covid-19 and in comparison with a study conducted at the university hospital of angers and the hospital of le mans in 2017.


Eligibility criteria:
inclusion criteria: * all adults patients consulting in the emergency department and agreeing to answer the questionnaire exclusion criteria: * patient admitted in the emergency department in serious condition (life distress) * person unable to consent
a study on disease awareness and treatment compliance of heart failure patients

Conditions: Heart Failure

Summary: the awareness hf-pd is a cross-sectional, multicenter, survey-based study. cases who were admitted to the outpatient clinic and hospitalized with the diagnosis of heart failure (acute and chronic) will be included in the study.

data entry personnel to be assigned at the centers throughout the study will apply a questionnaire consisting of different questions to patients referred to them by clinicians with the diagnosis of hf. in addition, clinical features of hf from the current file of the cases (nyha, comorbid conditions, comorbid diseases, blood pressure, heart rate, latest biochemistry (bnp/ntprobnp if available), hematology test results, most recent ecg, most recent echocardiography , coronary angiography report, if any) will be recorded. no additional examination/procedure will be performed for the study, only the data of the examinations requested by the clinician in routine clinical practice will be entered. a total of 200 patients from 3 centers will be included in this study over a six-month period.

Eligibility criteria:
inclusion criteria: 1. male or female patients aged 18 and over 2. patients diagnosed with acute or chronic heart failure 3. patients who agreed to participate in the study exclusion criteria: 1. patients who stated that they did not agree to participate in the study 2. patients who were not diagnosed with heart failure or whose diagnosis was changed or not confirmed during the index application 3. pregnancy

Keywords: heart failure questionnaire echo prospective
glp-1 loading during elective percutaneous coronary intervention

Conditions: Angina Pectoris; Myocardial Infarction; Reperfusion Injury; Coronary Heart Disease

Summary: angina is caused by narrowings or blockages within coronary arteries. coronary angioplasty and stenting is performed for people with angina to improve the blood supply to the heart by placing metal tubes within the artery using balloon inflation. the procedure risks small but significant damage to the heart muscle downstream of the balloon. glucagon like peptide 1 (glp 1) is a naturally occurring hormone secreted by cells in the gut in response to food. it acts by stimulating the release of insulin. in the heart it acts to increase glucose uptake into cardiac muscle. glp-1 can protect the heart and improve heart muscle performance in people with coronary artery disease in physiological studies. this study which assesses whether glp-1 protects the heart during coronary angioplasty and stenting. the hypothesis is that glp-1 given during elective coronary angioplasty and stenting will reduce cardiac troponin rise (a measure of heart muscle damage) compared to placebo.


Eligibility criteria:
inclusion criteria: * undergoing elective pci * age over 18 * able to give informed consent exclusion criteria: * severe co-morbidity (expected life expectancy \< 6 months) * nicorandil, glibenclamide, sitagliptin, vildagliptin, saxagliptin, linagliptin, liraglutide, exenatide and insulin use * women of child bearing age * breast-feeding women * myocardial infarction within the previous 3 months * baseline elevation of troponin i before pci * chronic renal impairment (serum creatinine \> 160 μmol/l)

Keywords: angina pectoris percutaneous coronary intervention myocardial infarction glucagon-like peptide 1 reperfusion injury
secondary intraocular lens implantation in pediatric patients

Conditions: Congenital Cataract

Summary: this prospective, non-randomized controlled study aiming at comparing the prognosis of minimal invasive lens surgery and traditional cataract surgery for treating congenital cataracts after the patient receives secondary intraocular artificial lens (iol) implantation.

pediatric patients received minimal invasive surgery and traditional lens removal surgery (anterior capsulorhexis and irrigation/aspiration and posterior capsulorhexis and anterior vitrectomy) are enrolled. the patients are assigned to two groups according to the strategy of primary surgery: group i: the participants received minimal invasive surgery, while in group ii, the participants received a traditional cataract surgery. investigators perform a secondary intraocular lens implantation for the patients. investigators compare the visual acuity, incidence of high intraocular pressure, incidence of visual axis opacification, uveitis and iris/pupil abnormality between two groups after the first and the second surgery, aiming at comparing the prognosis of minimal invasive lens surgery and traditional cataract surgery for treating congenital cataracts.

Eligibility criteria:
inclusion criteria: age between 24 months and 72 months uncomplicated congenital cataract and underwent cataract removal informed consent signed by a parent or legal guardian exclusion criteria: * intraocular pressure \>21 mmhg at enrollment preterm birth (\<28 weeks) presence of other ocular diseases (keratitis, keratoleukoma, aniridia, glaucoma) or systemic disease (congenital heart disease, ischemic encephalopathy) history of ocular diseases (any congenital eye diseases, such as, congenital cataract, congenital glaucoma, congenital aniridia) in the family history of ocular trauma microcornea persistent hyperplastic primary vitreous rubella lowe syndrome

Keywords: congenital cataract intra-capsular iol implantation ciliary sulcus fixation
pacu discharge without motorfunction assessment after spinal anaesthesia

Conditions: Osteoarthritis Susceptibility 3

Summary: the study investigates the safety of discharge from the post-anesthesia care unit (pacu) without assessment of motorfunction after spinal anesthesia for total hip- or knee replacement. this is an randomized controlled trial between two groups with assessment of normal (aldrete) pacu discharge criteria with or without assessment of the motorfunction. the study hypothesis is that it is safe to be discharged from the pacu to a ward without assessment of motor function. the main outcome is length of hospial stay (los) in days and re-admission within the first 30 days after surgery . secondary outcomes include adverse events up to 24 hours after surgery, and minuttes spent in the pacu after surgery. participants will be monitores for adverse events for the first 24 hours after surgery and reported. the total number of minuttes spent in the pacu will be recorded and reported.

a novel analysis of the latest database version was performed 06.04.2015, showing that 86.7% of patients have los of less than 5 days and no re-admission within the first 30 days after discharge. the study is designed as a non-inferiority study with a two-sided 5% significance level, 80% power and a non-inferiority level of 5%, resulting in 2 x 725 patients (1500 in total including drop-outs). a 30-day re-admission period was chosen to detect complications that could be assumed to have occurred as a consequence of the potential earlier pacu discharge the study will also investigate length of stay, incidence of failed anesthesia, and reason for stay in pacu after tha and tka 24.11.2016 a substudy based upon the un-published data from the time in pacu will be performed to analyse factors related to adverse events occuring during the pacu stay, and description of specific organdysfunction based upon the recordings from the modifed aldrete discharge criteria. preoperative demographic data are collected from charts and the lundbeck centre for fast-track hip and knee replacement database, (lcdb), intraoperative data from anesthesia charts. a logistic regression analysis will be performed with the yes/no outcome of moderate/severe adverse pacu events at any time during pacu stay, and pre- and intr operatie variables.

Eligibility criteria:
inclusion criteria: * age 18 yr or more * primary unilateral total hip or knee arthroplasty * spinal anesthesia exclusion criteria: * intraoperative conversion to general anesthesia * intraoperative bleeding exceeding 750 ml.

Keywords: hip knee arthroplasty spinal anesthesia
validation of sleep monitoring algorithm based on smart watches

Conditions: Obstructive Sleep Apnea Syndrome

Summary: in recent years, wearable devices are booming to enable not only the health monitoring but also the sleep efficiency assessment. to validate the algorithm of sleep staging and efficiency, this study will use a dedicated prototype to acquire photoplethysmogram (ppg), body movements, skin temperature, and galvanic skin response by recruiting 35 subjects. psg will be used as gold standard for statistical analysi.

sleep efficiency has a great impact on the performance of work and learning during the day. if persons lack of sleep for a long time, they might be prone to memory loss and emotional instability. traditionally, polysomnography (psg) has been proved as golden results to assess the sleep efficiency. however, to accomplish the assessment, subjects are asked to sleep in a certified sleep laboratory or a sleep centers for nights. under the supervision of nurses, subjects are put many adhesive electrodes on the body and connect wires to psg, which causes discomfort. in recent years, wearable devices are booming to enable not only the health monitoring but also the sleep efficiency assessment. to validate the algorithm of sleep staging and efficiency, this study will use a dedicated prototype to acquire photoplethysmogram (ppg), body movements, skin temperature, and galvanic skin response by recruiting 35 subjects. psg will be used as gold standard for statistical analysi.

Eligibility criteria:
inclusion criteria: 1. forty male or female subjects are recruited from those visiting department of medicine for health check up 2. subjects aged 20 to 65 exclusion criteria: 1. refuse to participate 2. arrhythmia 3. active infection 4. active neurologic event 5. shift worker 6. substance abuse 7. fitted with implantable medical electronics, such as cardiac pacemakers and defibrillators

Keywords: polysomnography sleep staging sleep efficiency wearable devices smart watches
motivational enhancement therapy's impact on d copd outcomes in geriatric patient

Conditions: COPD

Summary: motivational enhancement therapy (met) is a systematic intervention that focuses on eliciting and strengthening a person's intrinsic motivation to change. met is rooted in motivational interviewing principles, emphasizing empathy, autonomy, and the evocation of the patient's own motivations for change. the therapy typically involves several sessions where therapists help patients identify personal goals, explore ambivalence towards change, and develop actionable plans to achieve their desired outcomes.

chronic obstructive pulmonary disease (copd) is a leading cause of morbidity and mortality worldwide, particularly among the elderly. managing copd effectively in geriatric patients requires addressing not only the physiological aspects of the disease but also the psychological and motivational factors that can influence treatment adherence and overall well-being. motivational enhancement therapy (met) is a counseling approach designed to help individuals enhance their motivation to change and engage in healthier behaviors. this study explores the impact of met on motivation, resilience, anxiety reduction, and copd outcomes in geriatric patients.

Eligibility criteria:
inclusion criteria: * more than 60 years exclusion criteria: * more than 80 years
comparison of obesity alleles among diverse demographic patients

Conditions: Obesity

Summary: this proposal is designed to (1) establish the feasibility of a research strategy for discovering ethnic differences in the frequency of genotypes in patients after bariatric surgery and (2) perform a preliminary evaluation of this research strategy. our goal is to identify genetic factors that may influence the success of various surgical weight loss interventions and determine whether these factors are associated with specific patient populations.

goals: 1. establish feasibility of obtaining research consent on patients to collect clinical data, family history, and blood samples. 2. complete comprehensive genetic analyses on a diverse group of severely obese patients who have undergone bariatric surgery, specifically the primarily non-caucasian bellevue population and the caucasian population of geisinger health systems and nyu langone weight management program, to help define genetic factors that influence which surgical interventions work best for which patients. the ultimate aim is to rapidly translate these discoveries into practical solutions. methods and procedures: the participants of this study are all patients who have undergone bariatric surgery at bellevue hospital, nyu langone weight management program, and geisinger health system. the investigators have already completed this in 200 patients and plan to increase enrollment for a total of 2500 patients. the investigators will collect blood samples on bariatric surgery patients and send the blood to geisinger for genotyping and analysis. an extra sample of venous blood (about 4 tablespoons or 40ml) will be collected at the time of routine postoperative visits. in addition, the investigators will use information that has routinely been and will be collected during postoperative visits as part of the care that bariatric patients receive. the investigators will look at the electronic medical record to obtain the preoperative weights. this includes questionnaires patients complete and the results of the laboratory tests and other studies.

Eligibility criteria:
inclusion criteria: * all patients who have undergone any type of bariatric surgery exclusion criteria: * patients who have not had bariatric surgery

Keywords: bariatric surgery
efficacy study of kissing drug-eluting balloons in coronary bifurcation lesions

Conditions: Coronary Artery Disease; Bifurcation Lesions

Summary: kissing debbie's aim at assessing angiographic and clinical outcomes of provisional treatment of coronary bifurca6on lesions according to tap sten6ng with bms and final kissing deb


Eligibility criteria:
inclusion criteria: * age \>18 years * de novo major bifurca6on lesion of the left coronary artery (lad-d; lcx-om) * rvd 2.25-4.0 mm exclusion criteria: * lmca * ami within 48 hours * limited compliance with 3-month dual antiplatelet therapy

Keywords: coronary bifurcation lesions
epidemiologic, clinical and genetic profile of prostate cancer in arab countries

Conditions: Prostate Cancer

Summary: this protocol is designed to collect a small amount of blood and tissue from individuals with prostate cancer for extraction of dna (genetic material) for the study of the genetic basis of prostate cancer. the study population will include individuals with known prostate cancer and controls without prostate cancer. the study will be conducted in doha, qatar at the hamad medical corporation and weill cornell medical college (qatar). individuals in the study population will be of arab descent from qatar. in this protocol, researchers will survey epidemiologic factors and medical records of patients with prostate cancer in order to study the clinical characteristics of these individuals. the researchers will collect blood and tissue samples to evaluate the genetic characteristics of individuals with prostate cancer. the researchers will also collect blood samples of individuals without prostate cancer to serve as a control. the goal will be to identify genes that are associated with prostate cancer and gene profiles that are associated with differing prognoses in individuals who have prostate cancer.

the study population will include individuals with known prostate cancer and controls without prostate cancer. individuals in the study population will be of arab descent from qatar. in this protocol, researchers will survey epidemiologic factors and medical records of patients with prostate cancer in order to study the clinical characteristics of these individuals. the researchers will collect blood and tissue samples to evaluate the genetic characteristics of individuals with prostate cancer. the researchers will also collect blood samples of individuals without prostate cancer to serve as a control. the goal will be to identify genes that are associated with prostate cancer and gene profiles that are associated with differing prognoses in individuals who have prostate cancer.

Eligibility criteria:
inclusion/exclusion criteria for normal cohort inclusion criteria: * all study subjects should be able to provide informed consent * males or females ages 40 years or older (see section a8 for the rationale for the inclusion of females) * individuals of arab descent from qatari peninsula without any personal or family history of prostate cancer exclusion criteria: * individuals with family history of prostate cancer * individuals not deemed in good overall health by the investigator will not be accepted into the study inclusion/exclusion criteria for prostate cohort inclusion criteria: * all study subjects should be able to provide informed consent * males ages 40 years or older * individuals from the qatari peninsula whose ancestors up to three generations back were natives of qatar. * individuals undergoing trans rectal ultrasound (trus) biopsy as dictated by their standard clinical care * ultrasound or digital rectal examination consistent with prostate disease or a level of psa (prostatic specific antigen) greater than 3.0 exclusion criteria: • patient refuses consent

Keywords: prostate cancer genetics
family based intervention in childhood obesity

Conditions: Obesity

Summary: the study compares the effect on bmi of two different treatment options for obesity in childhood. families with at least one obese child and parent are invited to join the project. the hypothesis is that family camp gives an additional reduction in bmi compared to a less intensive family lifestyle school.

participants are randomised to two intervention groups: a): two weeks family camp and two years follow-up as a cooperation with primary health care, private rehabilitation center and specialist health care. b): four days lifestyle school with two years follow-up as a cooperation with primary health care and specialist health care

Eligibility criteria:
inclusion criteria: * age 7 to 12 years * bmi \> iso-bmi 30 (coles index) exclusion criteria: * syndromatic obesity * obesity related to diseases * local community not involved * child has present follow-up because of obesity in secondary health care * parent has present/planned follow-up because of obesity in secondary health care

Keywords: obesity child parent family