Kornimate/medical-research-clean huggingface dataset:
the effect of solution-focused group therapy for pain management in patients with spinal cord injury

Conditions: Pain Management; Life Quality; Spinal Cord Injuries

Summary: objective: to verify the effect of solution-focused group therapy (sfbt) on pain management as well as physiological, psychological and social adaptation in patients with spinal cord injury. setting: for matters of convenience, the samples were collected at medical and rehabilitation centers in taiwan. twenty-six patients with spinal cord injuries and neuropathic pain were invited to join the four pain management groups. method: in the case of patients with spinal cord injury affected by neuropathic pain, a solution-focused pain management group therapy was conducted once a week for 6 weeks, 90 minutes each time; fear avoidance theory and acceptance and commitment therapy was used for pain management, using solution-focus group counseling strategies to guide group members to achieve pain management goals by accepting pain and establishing goals.the group effectiveness was assessed before and after the group intervention in terms of pain intensity (0-10 numeric rating scale), brief pain inventory-pain inference, chronic pain self-efficacy scale, pain fear (0-10 numeric rating scale), depression (patient health questionnaire-9), demoralization (demoralization scale), post-traumatic growth inventory and life quality (whoqol-bref). then we analyzed the correlation between the difference values of the variables before and after the test in order to understand the clinical application of the pain management group therapy for patients with spinal cord injury.


Eligibility criteria:
inclusion criteria: * patients diagnosed with spinal cord injury as being in compliance with the taiwan national health insurance's definition exclusion criteria: * psychiatric disabilities * intellectual disabilities * unconscious patients * patients in critical condition * bedridden patients

Keywords: spinal cord injury pain management pain intensity pain self-efficacy solution-focused group therapy
ctdna methylation application in postoperative relapse and adjuvant chemotherapy efficacy evaluation

Conditions: Cancer Colorectal

Summary: in this study, the investigators aimed to apply their previously developed multi-locus blood-based assay targeting circulating tumor dna methylation to monitor postoperative relapse and evaluate adjuvant chemotherapy efficacy in resected stage i and stage ii (without high risk) colorectal cancer after radical resection.

this is a prospective, multicenter, observational, real-world study. research objects: patients with surgically resectable colorectal cancer and ctdna positive before surgery in stage i and stage ii (without high risk). after giving fully informed consent, the participants will undergo the regular treatment according to nccn guidelines. serial analysis of ctdna will be performed at specific time points including pre-treatment, postoperative week 3, postoperative 5 years ( every 3 months for the first 2 years, and every 6 months for the rest 3 years). participants will be observed and examined during the follow-up period.

Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed stage i/ii (without high risk) colorectal cancer. * male or female ≥ 18 years of age on the day of signing informed consent. * patients need to receive surgical resection, and with ctdna positive prior to resection of colorectal cancer (crc). * patients must have a performance status of ≤1 on the eastern cooperative oncology group (ecog) performance scale. * written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study. exclusion criteria: * personal history of colorectal cancer, colorectal adenoma or aerodigestive tract cancer. * induction of neoadjuvant systemic therapy prior to resection of crc. * patient is pregnant or lactating. * patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the investigator. * inadequate tumor material (either quality and quantity) to support circulating tumor dna (ctdna) analysis.

Keywords: early detection
hospitalary chronic obstructive pulmonary disease registry

Conditions: COPD Exacerbations; Death

Summary: the purpose of this study is to create an institutional registry of chronic obstructive pulmonary disease through a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival.

the main goal is to describe the characteristics of chronic obstructive pulmonary disease patients, including their clinical, spirometric, exacerbation and mortality characteristics within the population of the hospital italiano de buenos aires.

Eligibility criteria:
inclusion criteria: * patients older than 40 years with a chronic obstructive pulmonary disease diagnosis according to global obstructive lung global initiative for chronic obstructive lung disease criteria. * follow up at the hospital italiano de buenos aires. exclusion criteria: * refusal to participate or to agree to the informed consent. * known non chronic obstructive pulmonary disease respiratory disease (ej: lung cancer, tuberculosis, pulmonary fibrosis, neumoconiosis, cystic fibrosis, sarcoidosis, etc) * severe alpha-1 antitripsin deficit (typr sz or zz) * previously thoracic surgery (ej: lung volume reduction, lung transplantation).
a study to evaluate the efficacy and safety of zx-7101a tablets in adults with uncomplicated influenza

Conditions: Influenza, Human

Summary: the goal of this clinical trial is to compare zx-7101a in chinese adults patients with uncomplicated influenza. the main questions it aims to answer are: * the efficacy of zx-7101a in chinese adults patients with uncomplicated influenza. * the safety of zx-7101a in chinese adults patients with uncomplicated influenza.


Eligibility criteria:
inclusion criteria: * ≥18 to ≤64 years of age at the time of signing the icf. * patients in the screening period met the following criteria: (1) rapid influenza diagnostic test (ridt) or polymerase chain reaction (pcr) test positive; (2) fever ≥ 37.3℃ (axillary temperature) at screening; if taking antipyretics, axillary temperature ≥ 37.3℃ after taking the drug (more than 4 hours). (3) at least one of flu-related systemic symptoms is moderate or greater in severity: a. muscle or joint pain, b. fatigue, c. headache, d. fever. (4) at least one of the influenza-related respiratory symptoms is moderate or greater in severity: a. nasal congestion, b. sore throat, c. cough. * the first occurrence of influenza symptoms ≤ 48 hours from the time of patient randomization. exclusion criteria: * patients with influenza virus infection requiring hospitalization. * high-risk population. * bronchitis, pneumonia, pleural effusion or interstitial disease suspected by a clinician or confirmed by chest imaging \[x-ray (anteroposterior or anteroposterior)/ct\] and judged clinically significant by the investigator at screening. * patients who have developed acute respiratory tract infection, otitis media, and sinusitis within 2 weeks before screening. * patients with other infections requiring systemic anti-infective treatment, or blood routine examination at screening: white blood cell count (wbc) \> 10.0 × 109/l. * patients with purulent sputum or suppurative tonsillitis. * those who have difficulty in swallowing drugs or have a history of gastrointestinal diseases that seriously affect drug absorption. * medications against influenza virus within 7 days prior to screening.
maternal diabetes in newborns with hearing loss

Conditions: Gestational Diabetes; Pregestational Diabetes; Hearing Loss

Summary: this study aims to investigate the presence and characteristics of maternal diabetes as a risk factor in newborns with hearing loss. hearing loss is one of the most common congenital anomalies among newborns. the newborn hearing screening program is important for early diagnosis in newborns with hearing loss.gestational diabetes, on the other hand, is a metabolic disease that occurs during pregnancy and can cause complications as in other diabetes mellitus patients. despite our knowledge of major complications, the effect of the hyperglycemic intrauterine environment on hearing outcomes has not been adequately studied. the inner ear does not store energy, so it has a particularly high sensitivity to altered blood sugar and insulin. altered inner ear metabolism leads to auditory and balance disorders. there is no study in the literature comparing uncomplicated gestational diabetes and pregestational diabetes as a prenatal complication that poses a risk of hearing loss.


Eligibility criteria:
inclusion criteria: * postnatal age between 0-28 days * birth weight ≥2000gr * to have tested on the newborn hearing screening unit at ankara city hospital exclusion criteria: * preterms * craniofacial anomalies * intrauterine infections * birth weight \<2000 gr
field paramedic application of sepsis triage

Conditions: Sepsis

Summary: given the implementation of the hamilton early warning score (hews) and the use of capnography by paramedics, this study will involve a large multi-site retrospective evaluation (before vs after implementation) of the hews score and comparison of the hews to systemic inflammatory response syndrome (sirs), quick sepsis related organ failure assessment (qsofa) and modified early warning score (mews) when applied retrospectively for the identification of sepsis in the prehospital setting.

1. to determine the accuracy of the hews score, compared to qsofa, and sirs for early sepsis recognition when used in the prehospital setting by paramedics for the identification of patients with sepsis or suspected sepsis. 2. to evaluate the addition of etco2 values to predict mortality in patients who screen positive for sepsis. 3. to identify the before and after healthcare outcomes of a prehospital sepsis alert program.

Eligibility criteria:
inclusion criteria: any patient to which paramedics apply the hamilton early warning score or patients who arrive to the emergency department (ed) by ambulance without a pre-alert and meet the definition of sepsis in the ed will also be included, and patient is ≥ 18 years exclusion criteria: patient is an inter-facility transfer, or patients with absent vital signs are absent, or death before blood can be drawn in the emergency department, or the patient fits the criteria for another prehospital alert (st-elevation myocardial infarction, cerebrovascular vascular accident, or trauma)

Keywords: sepsis, septic shock, early warning scores, infecion
one week aligner evaluation

Conditions: Malocclusion

Summary: the purpose of this study is to demonstrate that changing aligners weekly provides similar results to changing aligners every two weeks.

the invisalign® system consists of a series of clear plastic aligners that are intended to replace conventional wire and bracket technology for many orthodontic cases. each custom manufactured aligner exerts gentle, continuous forces to move teeth incrementally from their original state to a final, treated state. the aligners are designed to optimally move each tooth at a speed that follows physiologic principles. the purpose of this study is to demonstrate that changing aligners weekly provides similar results to changing aligners every two weeks.

Eligibility criteria:
inclusion criteria: * subject must have fully erupted dentition except for 2nd and 3rd molars * for teen treatment group, subjects ages \<17 years of age * for adult treatment group, subjects ≥17 years of age exclusion criteria: * subject has undergone any accelerated orthodontic treatment prior to or during treatment as part of this study * subject with active caries * subject with periodontal disease * subject with tmd symptoms * subject has known allergy to latex or plastic * subjects who are pregnant or will become pregnant during treatment
fentanyl transdermal matrix patch zr-02-01 to treat moderate to severe cancer pain

Conditions: Pain; Cancer

Summary: the purpose of this study is to evaluate the safety of the matrix fentanyl patch zr-02-01 in providing relief of cancer pain.

this study will evaluate the safety of the matrix fentanyl patch. the study will be conducted in opioid-tolerant patients with moderate to severe cancer pain currently taking an around-the-clock opioid. patients will discontinue their current opioid regimen and begin using zr-02-01 as soon as possible under the direction of the physician investigator upon entry into the study. patient's dose of zr-02-01 will be determined by the investigator using sponsor-provided conversion. pain therapy will be under the supervision of the physician investigator.

Eligibility criteria:
inclusion criteria: * patient is at least 18 and no older than 75 years of age at the time of screening * patient has a diagnosis of cancer * patient has moderate to severe pain that is related to cancer or its treatment and is expected to last indefinitely and is currently taking an around-the-clock opioid to treat his/her pain * patient is already receiving opioid therapy, has demonstrated opioid tolerance * a responsible adult caregiver is available in the event of an emergency at home exclusion criteria: * patient has uncontrolled or rapidly escalating pain as determined by the investigator * patient has a history of substance abuse or has a substance abuse disorder

Keywords: pain cancer chronic pain
rest petco2 as a predictor of post-operative complications

Conditions: Post-Op Complication

Summary: cardiopulmonary exercise testing (cpet) is considered to be a golden standard in preoperative risk assessment and stratification of high risk patients scheduled for major surgery. however, not all of the patients requiring surgery are willing or able to complete this type of testing. vascular surgery patients are predominantly elderly people, with significant comorbidity and high degree of frailty and often can not undergo cpet. in recent years, new parameters with similar prognostic value as standard cpet parameters were studied. specifically, the partial pressure of end-tidal carbon dioxide (petco2) at rest has been shown to have the same prognostic value as ventilatory efficiency. we hypothesized low petco2 at rest will be associated with the development of pulmonary and cardiovascular post-operative complications in patients after major vascular surgery. accordingly, our aim is to compare petco2 measured at rest before surgery in patients who develop post-operative complications and in those who do not.

cardiopulmonary exercise testing (cpet) is considered to be a golden standard in preoperative risk assessment and stratification of high risk patients scheduled for major surgery. however, not all of the patients requiring surgery are willing or able to complete this type of testing. moreover, inability to perform cpet has been linked with inferior outcomes following surgery. vascular surgery patients are predominantly elderly people, with significant comorbidity and high degree of frailty. therefore, cpet as a mean of risk stratification would be of an especial interest in this group of patients. however, vascular surgery patients often present with peripheral arterial disease, which may contribute to early leg ischemia during exercise and therefore invalid cardiorespiratory reserve function measurement. in recent years, new parameters with similar prognostic value as standard cpet parameters were studied. specifically, the partial pressure of end-tidal carbon dioxide (petco2) at rest has been shown to have the same prognostic value as ventilatory efficiency in the prediction of post-operative complications in lung resection surgery patients. whether the same parameter can be used to predict postoperative complications in a different sub-set of surgical patients (i.e. vascular surgery patients) is yet to be determined. we hypothesized low petco2 at rest will be associated with the development of pulmonary and cardiovascular post-operative complications in patients after major vascular surgery. accordingly, our aim is to compare petco2 measured at rest before surgery in patients who develop post-operative complications and in those who do not.

Eligibility criteria:
inclusion criteria: * indication for major vascular surgery (aortobifemoral bypass surgery) exclusion criteria: * tracheostomy

Keywords: vascular surgery cardiopulmonary exercise testing end-tidal co2
study of pd-1 antibody and parp inhibitor in extensive stage small cell lung cancer

Conditions: Small Cell Lung Cancer

Summary: this is a phase ii, open, single-center study of camrelizumab and fluzoparib as consolidation treatment for patients with extensive stage small cell lung cancer who have not progressed after first-line treatment


Eligibility criteria:
inclusion criteria: 1. all subjects were required to sign the informed consent before starting the study; 2. histologically documented extensive stage small cell lung cancer； 3. ecog ps 0\~1 ； 4. 18-75 years； 5. according to recist1.1, cr or pr was achieved after 4-6 cycles of first-line etoposide and platinum chemotherapy; 6. .life expectancy ≥ 3 months； exclusion criteria: 1. recurrence or distant metastasis of localized small cell lung cancer after chemotherapy or concurrent chemoradiotherapy； 2. active infection including tuberculosis, hiv, hepatitis b and c； 3. interstitial pneumonia (ild), drug-induced pneumonia, radiation-induced pneumonia requiring steroid therapy or active pneumonia with clinical symptoms, or other moderate to severe lung diseases that seriously affect lung function; 4. severe infection existed, including but not limited to infection complications, bacteremia, severe pneumonia, etc; 5. symptomatic brain metastasis and cancerous meningitis;
protecting the eyes of gamers with lubricating eyedrops

Conditions: Dry Eye Syndromes; Computer Vision Syndrome

Summary: the excessive use of screens particularly amongst digital gamers can adversely impact the health of the surface of the eyes with symptoms and signs of surface damage. while strategies including limiting screen time exist, these may be ineffective given the widespread rise of digital device use and gaming culture in the modern era. there is limited evidence for the protective effect of lubricating eyedrops on the ocular surface for handheld console and computer gamers. the aim of this study is to investigate the protective effect of a lubricating eyedrop (thealoz duo) on the surface of the eyes in handheld console and computer gamers. the main question it aims to answer is whether thealoz duo could protect the surface of the eyes from dessication and alleviate symptoms of dry eye disease in handheld console and computer gamers. participants will receive either the lubricating eyedrop first for 1 month, followed by a control condition (no eyedrops) for another month, or the other way round. participants will attend 3 visits in total, each separated by 1 month apart. during each visit, routine clinical assessments of the front of the eye will be conducted. subsequent findings from this timely study will help improve care of the surface of the eyes for a growing population of gamers worldwide.

this study will be a randomized, outcome assessor-masked, cross-over clinical study to assess the potential impact of thealoz duo lubricating eyedrop on symptoms and signs of dry eye disease in handheld console and computer gamers. all visits will be conducted at the aston dry eye clinic in aston university, birmingham, united kingdom.

Eligibility criteria:
inclusion criteria: * individuals with dryness symptoms as assessed with the ocular surface disease index (osdi score ≥ 13). * individuals who play handheld console and computer-based games ≥ 2 hours everyday on average * individuals who are comfortable and competent at using smartphone applications * age ≥ 18 years, male or female * able to provide written consent in english * able to instil the treatment lubricating eyedrop on their own, and return any provided eyedrop bottle to the researcher used at the end of the treatment * able to attend multiple visits (3 visits over 2 months) exclusion criteria: * pregnancy * use of any topical ocular medical eyedrops or lubricants in the 1 week prior to starting the study or during the study period. those who are using existing lubricating eyedrops and are interested in participating will be required to stop their lubricating eyedrops for 1 week prior to commencing the study * history of ocular surgery, trauma or infections in the past 6 months

Keywords: lubricating eyedrop artificial tears ocular surface
a 6-hour clinical evaluation of new daily-wear soft contact lenses

Conditions: Myopia

Summary: the purpose of this study is to validate the clinical performance of a new contact lens design when worn over a period of 6 hours compared to nelfilcon a (control).

the purpose of this study is to validate the clinical performance of a new contact lens design when worn over a period of 6 hours compared to nelfilcon a (control). the primary outcomes of interest are lens fit and lens fit preference.

Eligibility criteria:
inclusion criteria: * is at least 18 years of age and has full legal capacity to volunteer * has read, fully understood and signed the information consent letter * currently wears or has previously worn soft contact lenses * has spectacle cylinder ≤1.00d in both eyes. * has spherical contact lens power requirement between -1.00d and -6.00d in both eyes. * has manifest refraction visual acuities (va) equal to or better than logmar equivalent of 20/25 in each eye. * has clear corneas and no active ocular disease * is willing and able to follow product usage instructions and maintain the visit schedule. exclusion criteria: * has never worn contact lenses before * has a systemic condition that in the opinion of the investigator may affect a study outcome variable * is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable * has any known active ocular disease and/or infection * has a monovision correction * has any ocular pathology or severe insufficiency of lacrimal secretion (moderate to severe dry eyes) that would affect the wearing of contact lenses * is aphakic * has undergone corneal refractive surgery * is pregnant or lactating, determined by self-report