Kornimate/medical-research-clean huggingface dataset:
multicomponent exercise in people with dementia

Conditions: Dementia

Summary: people with dementia shows a decline in cognition, such as memory, executive function (ef), language, attention, and spatial orientation that is significant enough to interfere with the independence and daily functioning. previous studies reported that multicomponent exercise improved ef in people with mild cognitive impairment and independence of adl in those with alzheimer's disease. however, few studies investigated whether multicomponent exercise improved ef, memory, and adl in people with dementia. therefore, the purposes of this study are to examine 1) the effect of multicomponent exercise on ef, memory, and adl in people with mild to moderate dementia; 2) the correlation between change in ef and adl; 3) the correlation between change in memory and adl.


Eligibility criteria:
inclusion criteria: * age: 60-80 y/o * mini-mental state examination: 10-26 * clinical dementia rating: 1-2 * walk at least 6 meters independently (with or without walking aids) exclusion criteria: * any other diagnosis of neurological diseases or musculoskeletal problems (except dementia) * physical or psychological comorbidities that affect performance during assessment or intervention * already participating in other physical training in the last 1 month
mass spectral fingerprinting in obstructive sleep apnoea

Conditions: Obstructive Sleep Apnoea (OSA); Exhaled Breath; Mass Spectrometry

Summary: to answer the question whether a previously detected breath profile in patients suffering from obstructive sleep apnoea (osa) can be found in a cohort of patients with suspected osa using mass spectrometry (validation study).


Eligibility criteria:
inclusion criteria: * clinical suspicion of obstructive sleep apnoea syndrome (based on clinical symptoms such as increased daytime sleepiness; epworth sleepiness score (ess) \> 10). * age between 18 and 85 years at study entry. exclusion criteria: * none
observation on the effect of auricular acupoint pressing on insomnia and adverse events in mhd

Conditions: Renal Dialysis; Sleep Initiation and Maintenance Disorders

Summary: maintenance hemodialysis (mhd) is one of the most important treatments for patients with end-stage renal failure. studies have found that insomnia is widespread in mhd patients, affecting their quality of life. auricular acupoint pressing is an effective traditional chinese medicine treatment for insomnia. this study compared the effects of auricular acupoint pressing and oral estazolam on insomnia in patients with mhd, and evaluated the possibility of auricular acupoint pressing to reduce the incidence of adverse events by improving insomnia in patients with mhd, and to explore the insomnia of mhd patients treated with tcm characteristics. the role and efficacy provide a basis for the treatment of sleep disorders by chinese medicine.


Eligibility criteria:
inclusion criteria: 1.age 18-90 years old，received maintenance hemodialysis treatment for more than 1 year, no history of surgical trauma, infection, trauma in the past 3 months; 2.the current condition is stable, the heart function is grade i, no limb paralysis, speech disadvantages and other sequelae； 3.informed consent volunteer to participate in this experiment. exclusion criteria: 1. at present, dialysis is inadequate, water and sodium retention is severe; 2. combined with severe cardiovascular disease, sequelae of cerebral infarction or history of cerebral hemorrhage, history of copd, history of myasthenia gravis, history of angle-closure glaucoma, blood system disease, mental system disease or other systemic the disease can not be matched with the experimenter; 3. poor compliance or poor medical attitude; 4. severe hearing or vision loss, or a very low level of education, can not match the experiment.
placebo controlled, randomized safety and efficacy study of rc-1291 in cancer anorexia/cachexia.

Conditions: Cancer Cachexia

Summary: anorexia and cachexia are devastating complications in late-stage cancer patients and is strongly associated with mortality in these patients. activation of ghrelin receptors have been demonstrated to stimulate appetite. rc-1291 hcl, by virtue of its ghrelin like activity and growth hormone releasing effects may have a dual role in the reversal of cancer induced anorexia and cachexia. this placebo controlled study will evaluate the safety and efficacy of rc-1291 hcl in cancer patients with anorexia and cachexia.


Eligibility criteria:
inclusion criteria: * community-dwelling patients ≥ 18 years of age with incurable,histologically diagnosed cancer. * involuntary loss of body weight of ≥ 5 % within the past 6 months exclusion criteria: * presently hospitalized or in a nursing care facility. * inability to increase food intake from secondary causes. * liver disease * if female-pregnant, breast-feeding or of childbearing potential.
reliability and validity of the turkish version of the gcps 2.0.(graded chronic pain scale 2.0)

Conditions: Chronic Pain; Scale Reliability Validity

Summary: this study was designed to conduct turkish adaptation, cross-cultural adaptation, validity, and reliability study of graded chronic pain scale 2.0 in order to use it for turkish people with chronic pain.

the gcps 2.0 is an eight-item scale that evaluates the severity of chronic pain, the presence of persistent pain due to pain days, and the degree of disability due to pain. it is easy, simple, useful and multidimensional. 80 volunteer participants who had chronic low back pain were studied.the data collection tools used in this study were; clinic and demographic evaluation form, oswestry low back pain disability index, patterns of activity measure pain, roland-morris disability questionnaire, hospital anxiety, and depression scale, and graded chronic pain scale 2.0. in this study, the forms were sent by e-mail. the snowball sampling method was used in the data collection process.the stages of the beaton protocol were followed in the translation of the scale. validity was evaluated with the face, content, and construct validity analyses. exploratory and confirmatory factor analyses were applied to determine the construct validity of the turkish version of the scale. reliability was evaluated with the test-retest method, the parallel forms method, and the internal consistency. ten days after completing the scale, 30 participants filled out the scale again for the test-retest method. one of the scales we used for the parallel forms method was rmdq and the other was odi.

Eligibility criteria:
inclusion criteria: participants were turkish speakers and volunteer participants aged 18 years and over and under 70 years of age who had recurrent or persistent chronic lbp for 6 months or more.the following participants with clbp diagnosed by a physician were included in the study. these; * disc herniations * mechanical back pain * lumbar strain * spondylolisthesis * degenerative disc disease * muscle imbalance * lumbago * a trigger point in the back muscles exclusion criteria: * having a history of illness such as psychiatric disorder, cognitive impairment, dementia, or alzheimer's * low back pain that needs immediate treatment (neoplasm, cauda equina syndrome, infection, fracture) * inflammatory low back pain * low back pain due to a vascular cause

Keywords: graded chronic pain scale chronic pain disability chronic low back pain validity and reliability
effect of comedy therapy on pain and anxiety levels after ureterorenoscopy

Conditions: Care Acceptor, Health; Pain, Postoperative; Anxiety Postoperative; Surgery

Summary: the aim is to determine the effect of comedy therapy on pain and anxiety levels in patients after uretero-renoscopy (urs) surgery. the hypotheses of this study; h1-0: comedy therapy has no effect on pain levels in patients after uretero-renoscopy surgery. h1-1: comedy therapy has an effect on pain levels in patients after uretero-renoscopy surgery. h2-0: comedy therapy has no effect on anxiety levels in patients after uretero-renoscopy surgery. h2-1: comedy therapy has an effect on anxiety levels in patients after uretero-renoscopy surgery.

intervention group after urs surgery, patients whose condition is stable after coming to the clinic will be given a patient introduction form, numerical rating scale, state-trait anxiety scales as a pre-test. patients will be shown 10-minute turkish comedy films prepared by the researchers. after the intervention, numerical rating scale, state-trait anxiety scales will be given as a post-test. control group after urs surgery, patients whose condition is stable after coming to the clinic will be given a patient introduction form, numerical rating scale, state-trait anxiety scales as a pre-test. no intervention will be made to control group patients. after a certain waiting period, numerical rating scale, state-trait anxiety scales will be given as a post-test.

Eligibility criteria:
inclusion criteria: * being over 18 years old, * not having any visual or auditory problems, * not having any communication problems, * not having any psychiatric problems. exclusion criteria: * not accepting to participate in the study or wanting to leave, * having had complications during the perioperative process.

Keywords: comedy therapy pain anxiety surgery
efficacy and safety study of hzt-501 in reducing the risk of ibuprofen-associated ulcers

Conditions: Peptic Ulcer

Summary: the purpose of this study is to evaluate whether hzt-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.

hzt-501 is a combination product including ibuprofen and the acid reducing agent famotidine. the study is designed to determine whether the combination product reduces the rate of ulcer development in subjects who require long-term daily use of ibuprofen. subjects will be assigned randomly, in approximately a 2:1 ratio, to treatment with either hzt-501 (ibuprofen 800 mg/famotidine 26.6 mg) or ibuprofen (800 mg) three times daily for a 24 week treatment period or until they develop either an endoscopically-diagnosed upper gastrointestinal ulcer and/or prohibitive toxicity. subjects will visit the study center for screening and at weeks 4, 8, 16, and 24. physical exams will be performed, and clinical laboratory measurements made, at selected times during the study. endoscopic exams will be performed during screening and at weeks 8, 16, and 24. subjects will be contacted four weeks following study completion. study with completed results acquired from horizon in 2024

Eligibility criteria:
inclusion criteria: * expected to require daily administration of a nonsteroidal anti-inflammatory drug (nsaid) for at least the coming six months for conditions such as osteoarthritis, rheumatoid arthritis, chronic low back pain, chronic regional pain syndrome, and chronic soft tissue pain. * did not use a nsaid within the 30 days prior to study entry exclusion criteria: * history of erosive esophagitis * history of any of the following serious gastrointestinal complications: * perforation of ulcers, * gastric outlet obstruction due to ulcers, * gastrointestinal bleeding. * active cardiac, renal, and/or hepatic disease * current helicobacter pylori (h. pylori) infection * use of an acid suppressant agent, misoprostol, or more than 325 mg/day of aspirin within the 14 days prior to study entry. * uncontrolled diabetes * uncontrolled hypertension * positive pregnancy test at screening * positive test at screening for human immunodeficiency virus (hiv), hepatitis b, or hepatitis c. * currently participating, or participation within 30 days prior to study entry, in an investigational drug study please note that there are other additional criteria. the study center will determine if patients meet all of the criteria.

Keywords: ibuprofen famotidine ulcers nsaids pain arthritis chronic regional pain syndrome chronic soft tissue pain osteoarthritis rheumatoid arthritis chronic low back pain
anti-inflammatory effect of therapeutic hypothermia in out-hospital cardiac arrest patients with cardiogenic shock

Conditions: Cardiac Arrest

Summary: acute myocardial infarction complicated with cardiogenic shock trigger il-6, the strong inflammatory response, result in multiple organ failure, even death. while therapeutic hypothermia,to expect the possibility of anti-inflammatory effect via il-6 bi-phasic effect and il-10 , to improve the multiple organ failure, to increase survival rate and well cerebral performance.

despite emergency coronary revascularization coupled with medical stabilization, intra-aortic balloon pump have significantly improved survival in patients with cardiogenic shock complicating acute myocardial infarction, mortality still remains excessively high, being actually about 30-50%. future research should focus on new therapeutic strategies, aimed to further decrease mortality rate of these patients or improve possible hospitalization and prognosis. heart pumping failure result in cardiogenic shock. increased la filling pressure result in acute pulmonary edema, hypoxemic respiratory failure, even congestive kidney and congestive liver. decreased stroke volume result in hypoperfusion obviously direct induce acute renal failure, disturbance consciousness and lactate accumulation, even, shock liver. multiple organ failure is the major mortality in the patients suffered from cardiogenic shock after acute myocardial infarction. cardiogenic shock remains the leading cause of death in patients hospitalized for myocardial infarction . systemic inflammation , especially endovascular interleukin-6, triggered by tumor necrosis factor-alfa and interleukin-1 beta result in inappropriate vasodilatation is observed in many patients with cardiogenic shock and may contribute to an excess mortality rate. in recent study, interleukin-6 represented a reliable independent early prognostic marker of 30-day mortality. therapeutic hypothermia (34℃) increase stroke volume, reduce muscle oxygen consumption and enhance anti-inflammatory action . the mechanism of anti-inflammatory effect for therapeutic hypothermia in cardiogenic shock is still unclear, need to further study in clinical trial. furthermore, this study will provide new strategy to increase survival rate in cardiogenic shock.

Eligibility criteria:
inclusion criteria: * age between 18-100 years * cardiogenic sock including initial lactate level \>18 mg/dl, necessary of vasopressor to keep mean artery pressure \>65mmhg after adequate fluid supply, and signs of reduced cardiac output including disturbance consciousness, cold limbs, decreased urine output, acute pulmonary congestion and so on. exclusion criteria: * patient or family refuse * metastatic cancer * pregnancy

Keywords: acute myocardial infarction, cardiogenic shock
immediate implants with customized abutments

Conditions: Edentulous Alveolar Ridge Atrophy

Summary: tooth extraction is followed by marked alterations of the tissue volume. the resorption process of at least the surrounding mucosa can be altered by using immediate implant placement and additional features such as immediate provisional crown, platform switching and grafting the gap between implant and buccal bone plate. the support of the gingival margin with a provisional crown led to an increase of buccal gingival tissue. teeth scheduled for extraction will be used to study the effect of a customized healing abutment. the following groups will be randomly assigned: control: a commercially available healing abutment will be screwed on top of the implant and a collagen sponge will be used to protect the graft. test: a customized peek abutment mimicking the subgingival emergence of the extracted tooth will be screw retained on top of the implant to seal the extraction site.

tooth extraction is followed by marked alterations of the tissue volume. incorporation of biomaterials into a fresh extraction socket can significantly reduce alveolar resorption but is not able to diminish the biologic process of the buccal bone plate. the resorption process of at least the surrounding mucosa can be altered by using immediate implant placement and additional features such as immediate provisional crown, platform switching and grafting the gap between implant and buccal bone plate. the support of the gingival margin with a provisional crown led to an increase of buccal gingival tissue. platform switching seems to be a viable option to reduce interproximal bone level alterations and to limit the buccal soft tissue recession. furthermore, augmenting the defect between the implant and the buccal bone plate has been proven to reduce the resorption process and lead to less shrinkage. the primary objective is: - the implant success the secondary objectives are: * the changes in mid-facial mucosal recession * the changes in papilla height * the changes in soft tissue ridge width * the aesthetic evaluation * the implant stability

Eligibility criteria:
inclusion criteria:• * the patient is ≥ 18 years old * extraction of single rooted tooth with healthy adjacent teeth (pd\<5mm, no bop) * patient must be able to understand the purpose of the study and to sign the consent form exclusion criteria: * smoking status of more than 10 cigarettes/day * history of uncontrolled metabolic disorders (e.g. diabetes mellitus) * history of malignancy, radiotherapy, or chemotherapy * pregnant or breast feeding * history of immunodeficiences * existence of metabolic bone disease or disease affecting bone healing * untreated or active periodontitis (bop and pd\>5mm) * absence or defects of the buccal bone plate

Keywords: immediate implants immediate provvisional soft tissue recession
functional implication of corpus callosum in voluntary strength in copd patients

Conditions: Neurophysiology; Physiology

Summary: patients with copd have lower capability of activating their muscles. at the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex. the aim of this study is to determine whether ipsilateral areas are functionally impaired in copd.

chronic obstructive pulmonary disease (copd) patients exhibit not only respiratory symptoms but also a peripheral muscular weakness. this weakness is characterized by a loss in strength, harmful for the patients' life quality and vital prognosis (swallow et al., 2007). even if many studies have enlightened damages at a peripheral level, the muscular atrophy itself cannot totally explain the loss in force (menon et al., 2012). furthermore, the contractile properties of copd muscles fibres are preserved (debigare et al., 2003). consequently, peripheral muscle weakness cannot only be explained by peripheral factors and central structures must be investigated. at the central level, it is admitted that force production is controlled by the activation of contralateral motor areas. in copd, these areas were found to be less activated than in controls during force production (alexandre et al., 2014). however, recent studies bring the evidence that ipsilateral motor areas are also mobilized to cope demand during such task. the activation of ipsilateral areas is possible through inter hemispheric pathways, as the corpus callosum. recently, the integrity of the corpus callosum have been linked to the capability of activating the ipsilateral motor cortex (chiou et al., 2014) during force production. this is of concern knowing that several studies reported white matter lesions in the brain of copd patients (dodd et al, 2012) and more precisely in regions containing the corpus callosum (lahousse et al., 2013). therefore, we hypothesize that copd patients have a lower capability of activating their ipsilateral motor cortex during force production compared to controls.

Eligibility criteria:
inclusion criteria: * health insurance * patients : copd gold ii-iv exclusion criteria: * pregnant women * seizures * unable to give written consent * metalic object above shoulders * dermatological issue concerning surface electrodes * caffeine consumption \> 4 coffee / day * neurological disorders * opioid-based treatment * patients : recent exacerbation (\< 4 weeks) * patients : rehabilitation in previous 1 year

Keywords: copd transcranial magnetic stimulation motor-evoked potentials muscle weakness interhemispheric inhibition
hepatocellular carcinoma (hcc)_torisel_

Conditions: Inoperable HCC

Summary: this is a phase i/ii study to evaluate dose limited toxicity and efficacy of torisel


Eligibility criteria:
inclusion criteria: * histologically confirmed hepatocellular carcinoma that is not amenable to curative resection * measurable disease * age \>=18 years. * life expectancy of greater than 12 weeks. * ecog performance status \<= 2 * prior systemic therapy for hcc is allowed * adequate haematologic, renal and hepatic function * absence of cirrhosis or child's a cirrhosis * fasting total cholesterol \<9.1 mmol/liter and fasting triglyceride level \<4.5 mmol/liter) exclusion criteria: * patients who have had systemic therapy or radiotherapy within 3 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 3 weeks earlier. * patients receiving any other investigational agents concurrently. * patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. * uncontrolled intercurrent diseases such as, but not limited to, ongoing or active infection, or psychiatric illness/social situations that would limit compliance with study requirements. * pregnant women.
midodrine during recovery from septic shock

Conditions: Hypotension; Shock, Septic; Sepsis

Summary: the purpose of this study is to determine whether midodrine administration decreases duration of intravenous vasopressors and intensive care unit length of stay for patients in septic shock.


Eligibility criteria:
inclusion criteria: * admitted to intensive care unit * diagnosis of septic shock on intravenous vasopressors * stable/decreasing doses of intravenous vasopressors * stable/improving organ function exclusion criteria: * allergy to midodrine * multiple intravenous vasopressors * increasing intravenous vasopressor requirements * worsening organ dysfunction * severe bradycardia

Keywords: critical care shock, septic sepsis hypotension midodrine
efficacy of lower tourniquet pressure during total knee arthroplasty

Conditions: Osteoarthritis

Summary: this study aims to determine whether the lower tourniquet pressure, which is set by adding 120mmhg (millimeter of mercury) on the systolic blood pressure just before tourniquet inflation, are efficient and safe during total knee arthroplasty, compared with the conventional tourniquet pressure: 150mmhg above the systolic blood pressure before tourniquet inflation.

we will compare the two groups of patients undergoing total knee arthroplasty, which the tourniquet pressure will be set differently: systolic blood pressure plus 120mmhg vs. systolic blood pressure plus 150mmhg, the conventional method, in terms of efficacy and safety.

Eligibility criteria:
inclusion criteria: * the patients undergoing total knee arthroplasty exclusion criteria: * systolic blood pressure measured at ward \> 200mmhg * thigh circumference \> 78cm * anesthesia other than spinal anesthesia * simultaneous bilateral total knee arthroplasty * the patients who disagreed the enrollment of this study

Keywords: tourniquet pressure total knee arthroplasty