Kornimate/medical-research-clean huggingface dataset:
transfusion requirements after orthotopic liver transplantation

Conditions: Anemia

Summary: the objective of this trial is to evaluate different transfusion strategies in patients after liver transplantation. patients in the experimental arm will be given red blood cell (rbc) transfusion according to a liberal strategy, i. e., transfusions should be given, when hemoglobin concentration falls below 10 g/dl, and hemoglobin concentration should be maintained between 10 and 12 g/dl. patients in the control arm will be given red blood cell (rbc) transfusion according to a restrictive strategy, i. e., transfusions should be given, when hemoglobin concentration falls below 8 g/dl, and hemoglobin concentration should be maintained between 8 and 10 g/dl.


Eligibility criteria:
inclusion criteria: * patients undergoing liver transplantation * patients considered to have euvolemia after initial treatment by attending physicians exclusion criteria: * patients age 18 or less * patients undergoing combined liver-kidney transplantation * patients requiring renal replacement therapy before liver transplantation for longer than two weeks * inability to receive blood products * patient with active blood loss at the time of enrollment * pregnancy * imminent death

Keywords: liver transplantation intensive care red blood cell transfusion
comparative effectiveness of hvt and bowen technique in patients of si joint dysfunction with upslipped innominates

Conditions: Joint Diseases

Summary: sacroiliac joint dysfunction (sijd) is a common musculoskeletal condition characterized by pain and impaired function in the lower back and pelvis region.

the reported prevalence of sacroiliac joint pain in cases of chronic low back and lower extremity pain is estimated to be between 10 - 27%. manual therapy techniques, such as high-velocity thrust (hvt) and the bowen technique, have emerged as potential treatment options for sijd. hvt involves quick, controlled movements applied to specific joints to restore normal range of motion and alleviate pain. conversely, the bowen technique is a gentle, non-invasive form of bodywork that utilizes subtle rolling movements over muscles and connective tissues to promote relaxation and restore balance within the body.

Eligibility criteria:
inclusion criteria: * diagnosis of sacroiliac joint dysfunction confirmed by clinical assessment and imaging findings. * the presence of an upslipped innominate observed on imaging studies. exclusion criteria: * history of significant trauma or surgery involving the sacroiliac joint region. * the presence of inflammatory or infectious conditions affecting the sacroiliac joint. * contraindications to manual therapy interventions such as hvt or the bowen technique. * inability to comprehend study procedures or provide informed consent
clinical study of umbilical cord tissue mesenchymal stem cells (uc-msc) for treatment of osteoarthritis

Conditions: Osteoarthritis of the Knee

Summary: allogeneic human umbilical cord tissue-derived stem cells injected intravenously (iv) once per day for 3 days or once intra-articularly are a safe and will induce a therapeutic effect in osteoarthritis (oa) patients.

the proposed study will assess primarily safety and secondary efficacy endpoints of allogeneic umbilical cord mesenchymal stem cells (uc-msc) administered to 40 patients with oa. arm 1 will receive one intra-articular injection of uc-msc into the knee and arm 2 will receive iv uc-msc once per day for 3 consecutive days. the primary objective of the trial is freedom from treatment associated adverse events at 3 and 12 months post treatment. secondary objective will be efficacy as assessed at baseline, and 3 and 12 months post treatment and will be quantified based on the western ontario and mcmaster osteoarthritis index (womac).

Eligibility criteria:
inclusion criteria: * signed informed consent by the subject. * age greater than or equal to 18 years * ability to understand the planned treatment. * idiopathic or secondary osteoarthritis of the knee with grade 2, 3, or 4 radiographic severity, as defined by the modified kellgren-lawrence classification exclusion criteria: * pregnant or lactating women * women of childbearing potential unwilling to use two forms of contraception * cognitively impaired adults. * presence of large meniscal tears ("bucket handle" tears), as detected by clinical examination or by magnetic resonance imaging. * inflammatory or postinfectious arthritis. * more than 5 degrees of varus or valgus deformity. * kellgren lawrence grade 4 osteoarthritis in two compartments (the medial or lateral compartments of the tibiofemoral joint or the patellofemoral compartment) in persons over 60 years of age. * intraarticular corticosteroid injection within the previous 3 months. * a major neurologic deficit. * serious medical illness with a life expectancy of less than 1 year. * prior admission for substance abuse * body mass index (bmi) of 40 kg/m2 or greater * patient receiving experimental medication or participating in another clinical study within 30 days of signing the informed consent * in the opinion of the investigator or the sponsor the patient is unsuitable for cellular therapy

Keywords: osteoarthritis knee stem cells mesenchymal umbilical cord
registry of preterm newborns with severe pulmonary hypertension

Conditions: Pulmonary Hypertension; Preterm Infant

Summary: the purpose of this prospective research registry is to collect data on treatment strategies and outcomes for premature newborns with severe pulmonary hypertension (ph).

there is a lack of consensus on the role of inhaled nitric oxide (ino) therapy and other pulmonary vasodilators for the treatment of severe pulmonary hypertension (ph) in premature newborns (\<34 weeks gestation). however, a proper randomized, controlled trial of ino in premature newborns with severe ph has not been completed. some practices embrace the american academy of pediatrics (aap) statement that there is no condition for which ino should be used in the premature newborn, and others selectively treat premature infants with inhaled nitric oxide (ino) who suffer life threatening hypoxemia due to suprasystemic ph and right-to-left veno-arterial admixture across the arterial duct and/or oval foramen. the number of neonatal intensive care units (nicus) adopting each of these approaches is currently unknown, but it is possible that the former group is increasing due to administrative pressure to reduce uncompensated off-label ino use. a prospective registry collection of treatment strategies and outcomes for this subset of premature newborns will help define current treatment strategies and yield important information about safety and efficacy of the different approaches to management, and would inform the debate more effectively than a series of ino treated infants alone. data collected includes maternal age, race/ethnicity, pregnancy and delivery complications, prenatal medications, infant characteristics such as apgar scores, birthweight, congenital anomalies, respiratory status, pharmacologic therapy used for ph and its side effects, and blood gas data. up to 100 sites in north america will be invited to monitor for appropriate cases.

Eligibility criteria:
inclusion criteria: * premature newborns 23-34 weeks gestation * echocardiographic evidence showing systemic or suprasystemic levels of ph, or \> 5% difference in pre-post ductal saturation if echo is not available. * fraction of inspired oxygen (fio2) \>0.60 in the first 72 hours after birth exclusion criteria: * none
functional melatonin replacement for sleep disruptions in individuals with tetraplegia

Conditions: Insomnia; Spinal Cord Injury; Tetraplegia; Sleep Disorders

Summary: the purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep disruption.


Eligibility criteria:
inclusion criteria: * age 18 years or older, male or female veterans of any racial or ethnic group * neurologically complete (frankel a or b) damage to the lower (c4-c8) cervical spinal cord * absence of melatonin production * time since sci is greater than 6 months \[no cases of acute spinal cord injury\] * subjective complaint of sleep disruption exclusion criteria: * current use of fluvoxamine (luvox , antidepressant), rifampin (antimycobacterial), ketoconazole (nizoral , antifungal), or fluconazole (diflucan , antifungal) \[these interact with the same liver enzyme that is the primary metabolizer of ramelteon\]; use of sleep medications is okay * hepatic dysfunction * concomitant use of over-the-counter melatonin * pregnancy or breast feeding * currently or have within the past six months met dsm-iv (diagnosis and statistical manual iv) criteria for drug or alcohol abuse or dependence or audit score \>19 * acute illness or unstable chronic illness. use of continuous positive airway pressure (cpap) for treatment of sleep apnea is acceptable. * no travel across three or more time zones within three weeks or during the protocol * illiterate or unable to read or write english or are judged by the investigator to be unable or unlikely to follow the study protocol

Keywords: sleep melatonin spinal cord injury insomnia tetraplegia
evaluation of effectiveness of virtual reality-based dispatcher assisted cardiopulmonary resuscitation training

Conditions: Cardiac Arrest

Summary: this study aims to compare the effect of conventional cardiopulmonary resuscitation (cpr) training and cpr training with added virtual reality (vr) on trainee self-efficacy.

this study aims to compare the conventional cardiopulmonary resuscitation (cpr) training program (heros cpr training program) with the heros vr (virtual reality) cpr training program to which the newly developed vr curriculum was added. the experimental group is the heros vr training group, and cpr training is conducted for approximately 60 minutes for 6 to 8 trainees per training. at the start and the end of the training, students are taught about cardiac arrest, recognition of emergency situations, and reporting to 119 by watching vr, and in the middle part, they practice chest compressions by watching conventional heros video. the control group is the existing heros training group. to control variables, the number of trainees per training was limited to 6 to 8, and the existing video-based cpr training was implemented. the investigators will conduct a modified basic resuscitation skills self-efficacy scale survey before and after training to compare the difference in the improvement of trainees' self-efficacy evaluation of cpr after cpr training in the heros vr curriculum and the existing heros curriculum.

Eligibility criteria:
inclusion criteria: * non-medical personnel aged 18\~65 exclusion criteria: * who have received cpr training within the past 1 year. * for whom it is difficult to wear the vr equipment due to a history of side effects or problems such as head trauma.

Keywords: cpr education virtual reality
realtime-elastography (rte) and thyroid nodules

Conditions: Thyroid Nodules

Summary: the study is an open, prospective multicenter study. according to the statistical sample size calculation 593 patients with thyroid nodules ≥ 5mm in size will be included in the study. reference methods are cytology obtained by fine needle aspiration biopsy (fnab) or histology obtained by surgery. all patients will receive an b-mode and duplex ultrasound examination of the thyroid gland, as well as realtime elastography of thyroid nodules. results of b-mode and duplex ultrasound are compared to realtime elastography to evaluate the additional value of realtime elastography in the diagnostic work up of thyroid nodules.


Eligibility criteria:
inclusion criteria: * patients with thyroid nodules ≥ 5mm in size and tsh ≥ 0,35µu/ml * cytology obtained by fnab or thyroid surgery planned * age ≥ 18 year * signed written consent exclusion criteria: * diseases which preclude study accomplishment or put the patient at any risk (e.g. psychiatric diseases) * non-contractually capable persons * pregnancy * lactation

Keywords: presenting for fnab or surgery
evaluation of emergency suturing with absorbable versus non-absorbable suture material in a pediatric population

Conditions: Wounds and Injuries

Summary: the investigators recruit patients admitted to the pediatric emergency department of the geneva's university hospital with open wounds needing suture. the patients are treated with absorbable versus non-absorbable suture material according to randomization. outcomes are: 1. infection rate at the first follow-up (between 4 and 14 days, depending on the sutured site and defined by protocol) 2. scar appearance at a 6-months follow-up.

the investigators recruit patients admitted to the pediatric emergency department of the geneva's university hospital with open wounds needing suture. the patients are treated with absorbable versus non-absorbable suture material according to randomization. after obtaining the patient's/parent's consent and randomization, the suture material will be provided. selection of the size of the thread and the date of the first follow-up are determined as follows: * face: thread size 5-0 to 7-0, first follow-up 4-7 days * torso/back: thread size 4-0 or 5-0, first follow-up 10-14 days * arms: thread size 4-0 or 5-0, first follow-up 7- 10 days * hand: thread size 5-0 or 6-0, first follow-up 7-10 days * legs: thread size 4-0 or 5-0, first follow-up 7-14 days the patients are examined by in the outpatient wound clinic by specialised nurses under medical supervision at the first follow-up, and at six months by one of the investigators. outcomes: 1. infection rate at the first follow-up (between 4 and 14 days, depending on the sutured site and defined by protocol) 2. scar appearance at a 6-months follow-up.

Eligibility criteria:
inclusion criteria: * patient younger than 16 years of age with a wound requiring suture exclusion criteria: * deep wounds with lesions of subcutaneous structures (tendons, nerves, etc.) * wounds with tissue loss * diabetic patients or patients treated with drugs potentially compromising cicatrization (e.g. steroids, immunosuppressors, etc.) * wounds caused by animal or human bites * sutures not performed in the emergency room * heavily soiled wounds

Keywords: wounds, penetrating child, preschool child infant adolescent sutures polyglactin 910 polypropylenes
endogenous estrogen and coronary heart disease in women

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Infarction; Postmenopause

Summary: to investigate the relation between endogenous levels of estrogen in postmenopausal women and the subsequent development of coronary heart disease.

background: studies suggest that estrogen replacement therapy (ert) lowers the risk of coronary heart disease in postmenopausal women. however, it is not known whether higher endogenous levels of estrogens in the postmenopausal period likewise have a protective effect. design narrative: the study used an existing resource of frozen blood samples from a cohort of 7,058 postmenopausal women enrolled between 1985 and 1991 for a study of endogenous hormones and cancer. the cohort was followed up to identify incident cases of coronary heart disease. one hundred thirty cases of coronary heart disease (defined as nonfatal myocardial infarction or death from coronary heart disease) were expected to occur by the end of follow-up. a nested case-control study was conducted in which each case was matched to two women from the cohort who were the same age as the case, donated blood around the same time, and were alive and free of heart disease as of the date of diagnosis of the case. frozen serum samples from cases and their matched controls were analyzed for total estradiol, bioavailable estradiol (the estradiol fraction not bound to sex hormone binding globulin) estrone, total cholesterol, and high- and low-density lipoprotein cholesterol. conditional logistic regression for matched sets were employed to determine whether estrogen levels were lower in the cases than their matched controls. the association between estrogen levels and cholesterol fractions was also investigated.

Eligibility criteria:
no eligibility criteria
valiant thoracic stent graft with the captivia delivery system in the treatment of descending thoracic aortic diseases (valiant captivia france)

Conditions: Aortic Aneurysm, Thoracic; Descending Thoracic Aortic Dissection; Penetrating Ulcer; Aorta Thoracic; Traumatic Rupture; Aortic Diseases

Summary: the objective of this study is to assess the benefits of endovascular technique in terms of efficacy and safety of valiant thoracic stent graft with the captivia delivery system in the treatment of thoracic aortic disease, in a cohort of patients representative of the population treated under real-life conditions of use in france for up to 5 years.

data regarding the use under routine practice of thoracic aortic stent grafts in france are expected by the french national authority for health (has). therefore, in its opinion report from december 22, 2009, has makes the maintenance of reimbursement approval of each stent graft dependent on the presentation of results of a specific follow-up study carried out in a cohort of patients representative of the french population treated under real-life conditions of use. this prospective cohort study must involve patients implanted after registration on the lppr (list of products and services qualifying for reimbursement). the results of the follow-up study must be forwarded to the national committee for evaluation of medical devices and health technologies (cnedimts) for examination once a year. the assessment of this follow-up could lead to the recommendation by cnedimts to continue or stop the reimbursement of the concerned stent graft. in france, the valiant thoracic stent graft with the captivia delivery system is registered on the lppr for a period of 3 years since january 12, 2011. in order to comply with has expectations, medtronic bakken research center is setting up this long term non-interventional study on the valiant thoracic stent graft with the captivia delivery system.

Eligibility criteria:
inclusion criteria: * any patient requiring placement of the valiant thoracic stent graft for the treatment of a disease of his/her descending thoracic aorta. * patient or holder of parental authority not opposed to the collection and release of the personal information required by the study. * patient or holder of parental authority has consented for study participation and the medtronic approved data release form has been signed and personally dated by patient or holder of parental authority and by the investigator. exclusion criteria: * patient in whom clinical follow-up will not be possible i.e. patient not able to come back for follow-up visits (ex. patient living abroad). * prior implantation of a thoracic stent graft.

Keywords: valiant captivia stent graft thoracic aortic
a retrospective database assessment of clinical effectiveness in type 2 diabetes patients treated with liraglutide from primary care centers in sweden

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this study is to investigate a retrospective database assessment of clinical effectiveness in type 2 diabetes patients treated with liraglutide from primary care centers in sweden.


Eligibility criteria:
inclusion criteria: * patients from emr (electronic medical record) system in the primary care in sweden * patients equal to or more than 18 years of age * starting treatment with liraglutide or sitagliptin from january 2010 to december 2013 * minimum of 180 days of prior follow-up/history within the database before their index date exclusion criteria: * patients with cancer, end stage liver disease, end stage renal failure (non-diabetes related) * female patients with gestational diabetes during pregnancy * patients with previous glp-1 (glucagon-like peptide-1) or dpp-iv (dipeptidyl peptidase-4 ) inhibitor use, i.e. patients should be incretin naïve
the predictive value of ureteral jet assessment with ultrasound in patients presenting with acute renal colic

Conditions: Ureteral Calculi

Summary: this is a single institution, prospective study to evaluate the prognostic significance of renal and bladder ultrasound with ureteral jet assessment and its utility to evaluate the spontaneous stone passage rate of ureteral stones.


Eligibility criteria:
inclusion criteria: * age 18 and older at the time of consent * willing and able to sign consent * ct diagnosis of ureteral stone with a stone burden less than or equal to 10mm exclusion criteria: * obstructed solitary kidney * obstructed transplant kidney * bilateral obstructed kidneys * any condition or reason that, in the opinion of the treating physician, interferes with the patient's ability to participate or places the patient at undue risk.

Keywords: stone ureter ultrasound
comparison of the analgesic effects of continuous versus single-shot serratus posterior superior intercostal plane block in arthroscopic shoulder surgery

Conditions: Arthroscopic Shoulder Surgery

Summary: patients undergoing arthroscopic shoulder surgery often experience moderate to severe postoperative pain. various medical treatments are employed to provide analgesia for these patients. the advancement of regional anesthesia techniques has made possible to both reduce the use of narcotic analgesics and provide long-term pain management benefits. the serratus posterior superior intercostal plane block (spsipb) was first described in 2023 by serkan tulgar et al. cadaveric studies and dermatomal analyses in patients have demonstrated its ability to provide analgesia in the back, neck, shoulder, axilla, and lateral thoracic regions. even though patients undergoing shoulder surgery benefit from the block; once the duration of a single-shot block wears off, they may experience severe pain again. the aim of this study is to investigate the analgesic effects of a single-shot spsipb compared to continuous infusion provided by placing a catheter in this region. the hypothesis of this study: in arthroscopic shoulder surgery, the continuous application of the serratus posterior superior intercostal plane block using a catheter will result in lower pain scores, reduced opioid consumption, and improved patient satisfaction compared to single-shot application.


Eligibility criteria:
inclusion criteria: * aged between 18-80 years * no bleeding diathesis * classified as asa i-ii-iii exclusion criteria: * patients who do not provide consent * patients with coagulopathy * history of allergy or intoxication to local anesthetic agents * patients with advanced organ failure * history of neuropathic disease * patients with mental retardation * presence of infection at the injection site * conditions in which regional anesthesia is contraindicated * pediatric patients and those over 80 years of age * pregnant patients

Keywords: serratus posterior superior intercostal plane block shoulder arthroscopy regional anesthesia plane block postoperative pain