Kornimate/medical-research-clean huggingface dataset:
attempts to stop/reduce marijuana among dependent users

Conditions: Marijuana Abuse; Marijuana Dependence

Summary: the purpose of the study is to determine why and how marijuana users stop or reduce their marijuana use.

the major aim of this study is to provide a better understanding of attempts to stop or reduce marijuana use that can be used to develop better behavioral treatments for marijuana dependence. the application will focus on adult daily marijuana users who try to stop or reduce their marijuana use in a real-world setting. although prospective, natural history studies describing attempts to stop or reduce alcohol, heroin and tobacco use have proved useful, we know of no such study among adult marijuana users. two pilot studies will develop measures and assess compliance with our procedures. the main study will recruit up to 400 adult marijuana smokers with the goal of a sample size of 200 participants with adequate compliance. participants will call an interactive voice recording (ivr) system daily for 3 months to report marijuana use, quit/reduction attempts, and events that might increase or decrease the probability of initiating a quit/reduction attempt or the success of an attempt. follow-up at 6 months will track recent marijuana and other drug use. knowing what motivates marijuana users to try to stop or reduce, and knowing which strategies for stopping marijuana use are successful, can help develop treatments for marijuana dependence. for example, if stopping tobacco when trying to stop marijuana decreases the chance of stopping marijuana, then smoking cessation should be done after stopping marijuana. or if reducing marijuana often leads to cessation, then convincing those not interested in quitting marijuana to first try reducing may be helpful.

Eligibility criteria:
inclusion criteria: * daily marijuana smokers for at least 1 year exclusion criteria: * pregnant women

Keywords: marijuana marijuana abuse marijuana dependence cannabis substance-related disorder abstinence
daily sessions of rtms to the left dlpfc modulate the pain thresholds and cpm

Conditions: Pain Relief

Summary: the main purpose of the study is to assess whether repeated sessions of repetitive trancranial magnetic stimulation (rtms) applied on left dorsolateral prefrontal cortex main boost the pain thresholds.

pain is the largest health-related burden on society and, despite many decades of pain research, there are still few effective treatments. since pain experience is a construct of the central nervous system (cns), chronic pain has been recently thought to be a cns disorder. repetitive transcranial magnetic stimulation (rtms) is a safe, non-invasive technique for cerebral cortex stimulation and the clinical applications of which have expanded considerably in recent years. recent studies have been shown that 'classical' rtms to different cortical areas temporary reduce chronic and acute pain, suggesting that rtms may ´have some clinical application in future management of chronic pain. however, new rtms paradigms involving theta burst stimulation (tbs) have recently been described with the major clinical advantage to be much shorter than 'classical' rtms. the investigators hypothesize that ctbs would yield analgesic effects similar to or, possibly, even stronger than those produced by 'classical' rtms. the investigators will carry out a sham-controlled, randomized, double-blind, crossover study in healthy volunteers, to compare the analgesic effects of two rtms protocols over dorsolateral prefrontal cortex: classical high-frequency rtms (10 hz), and tbs. as rtms-induced analgesia may be dependent on changes in pain modulatory systems, the investigators will analyze the effects of the stimulation on conditioned pain modulation (cpm). more specifically, the investigators will compare the effects of multiple sessions of rtms on the inhibition of a test experimental stimulus induced by heterotopic noxious stimuli, to assess possible changes in diffuse noxious inhibitory controls.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * major medical conditions

Keywords: repetitive transcranial magnetic stimulation dorsolateral prefrontal cortex pain thresholds
effect of a commonly used antibiotic, doxycycline, in women with polycystic ovarian syndrome

Conditions: Polycystic Ovarian Syndrome (PCOS); Irregular Menstrual Cycles; Androgen Excess

Summary: the purpose of this study is to study the effect of a commonly used antibiotic, doxycycline, on the production of ovarian hormones and menstrual cycles in women with polycystic ovarian syndrome (pcos).

polycystic ovarian syndrome (pcos) is one of the leading causes of female infertility, affecting 5-10% of reproductive-age women . this heterogeneous disorder is characterized by anovulatory infertility, androgen excess, an increase in the ratio of lh to fsh, and morphologic polycystic changes to the ovaries. obesity and insulin resistance are also metabolic factors associated with pcos that further increase the morbidity in these patients. inducing fertility in patients with pcos can be a challenge, as it most often involves ovulation induction that can lead to ovarian enlargement, hyperstimulation, and multiple-birth pregnancies. this study is designed to determine novel effective strategies to promote normal cycling in this patient population.

Eligibility criteria:
inclusion criteria: 1. women between 18 and 40 years of age. 2. history of pcos with \< 8 periods the proceeding year 3. clinical or biochemical evidence of androgen excess 4. bmi \<40 5. willingness to sign consent for study including participation with collection of blood specimens 6. willingness to discontinue ocp for duration of study period up to 36 weeks exclusion criteria: 1. pregnancy 2. hypersensitivity to doxycycline or tetracycline 3. history of cushing's syndrome 4. history of hyperprolactinemia 5. history of congenital adrenal hyperplasia 6. significant hepatic impairment, including serum ast or alt \>1.5 times upper limits of normal. 7. significant renal impairment, gfr \<60 ml/min 8. current use of metformin, statins, glucocorticoids, spironolactone and/or anti-estrogens.

Keywords: polycystic ovarian syndrome irregular menstrual cycles androgen excess in women
prevention of neuropathic pain from oxaliplatin by photobiomodulation

Conditions: Cancer of the Gastrointestinal Tract

Summary: peripheral neuropathy is one of the most common side effects of oxaliplatin (oxa)-based chemotherapy for patients treated for digestive cancers, disabling and dose-limiting. several strategies have been studied for the treatment of oxaliplatin-related sensory neuropathy. several pharmacological and non-pharmacological therapeutic strategies have been explored to relieve peripheral neuropathic pain. non-pharmacological interventions have been shown to be potentially beneficial for patients suffering from chemotherapy-induced neurotoxicity. the objective of this prospective study is to evaluate the effectiveness of photobiomodulation on the reduction of neuropathic pain in patients who developed painful, cumulative peripheral neuropathy that appeared under the effect of the treatment.


Eligibility criteria:
inclusion criteria: * recent diagnosis of digestive cancer * 12 planned cycles of oxaliplatin * ability to understand and willingness to sign an informed consent form before starting any study procedures * patient benefiting from french health insurance exclusion criteria: * history of neuropathy before the start of the study, * symptomatic treatment of pain (or neuropathic pain), * patient with a psychotic disorder, * patient with diabetic neuropathy, * patient with metastatic cancer * patient with renal insufficiency, * adults under guardianship or curatorship, * vulnerable people

Keywords: photobiomodulation pain oxaliplatin peripheral neuropathy chemotherapy sudoscan
improving brief marijuana interventions with a behavioral economic supplement

Conditions: Marijuana Use

Summary: the purpose of this study is to evaluate the efficacy of a substance-free activity session (sfas) as a supplement to a brief motivation intervention (bmi) in reducing marijuana use and drug-related consequences in college student

approximately 20% of college students are regular marijuana users, and are at risk for cognitive and academic problems, addiction, and risk behaviors such as driving while impaired. young adult marijuana users are thus a high-risk population and may require an intervention that motivates marijuana reductions by increasing engagement in constructive alternatives to marijuana use. brief motivational interventions (bmis) have demonstrated efficacy for alcohol use in college students, but lack consistent evidence of efficacy for marijuana use. this research team has developed a supplement to alcohol bmis, the substance-free activity session (sfas), which directly targets the behavioral economic mechanisms of both substance-free reinforcement and delayed reward discounting by encouraging the development of and commitment to academic and career goals, and by highlighting the impact of day-to-day patterns of alcohol use and academic engagement on these goals. a controlled pilot trial found that the sfas improved bmi outcomes in a sample of heavy drinking college students, and the ongoing parent trial to this revision is replicating and extending those results. this study will evaluate the sfas using a randomized 3-group (bmi + sfas vs. bmi + relaxation attention control, vs. assessment only) pilot trial with 120 undergraduates (50% female, 40% minority) who report using marijuana on \> 5 days in the past-month. it is hypothesized that at the 1-month and the next-semester follow-ups (follow-ups are wedded to the academic calendar to allow for representative measurement of marijuana use and activity patterns) bmi+sfas participants will report significantly lower levels of marijuana use and problems, and that these reductions will exceed those of bmi + relaxation and assessment-only participants. exploratory analyses will test the hypotheses that (a) the bmi + sfas will be more effective for participants who report higher baseline marijuana reinforcing efficacy and delayed reward discounting; and (b) the advantage of bmi + sfas on marijuana use will be mediated by increased participation in substance-free activities. support for our hypotheses would extend behavioral economic theory and would provide initial validation for an approach that could be used to reduce marijuana misuse among the increasing population of college students who misuse marijuana. furthermore, given the focus of the sfas is to increase academic/campus engagement, this work has the potential for widespread dissemination.

Eligibility criteria:
inclusion criteria: * freshman or sophomore at the university of memphis * 5 or more past-month days of marijuana use exclusion criteria: -
basal plus glp1-ra on glycemic variability in ckd

Conditions: Diabetes Mellitus; Diabetic Kidney Disease

Summary: to compare glp-1 ra plus basal insulin (bglp) versus basal-bolus (bb) insulin regimens on glycemic variability (gv) and time in range (tir) in diabetes patients ckd stage 3-4


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes mellitus diagnosed for at least 6 months 2. male or female age ≥ 18 years old and ≤ 75 years old. 3. body mass index between 18 and 40 kg/m2 inclusive 4. hba1c ≥ 6.5% and ≤ 9.0% at screening 5. women who are not pregnant, lactating or planning a pregnancy during their participation in the clinical study. 6. patients with ckd stage 3 or 4 as defined by estimated glomerular filtration rate between 15-59 ml/min/m2 by the modified chronic kidney disease epidemiology collaboration (ckd-epi) equation at screening 7. willingness, ability and commitment to comply with the testing, procedure and follow-up outlined in this protocol including (but not limited to) and use of pre-specified glucose monitoring devices. 8. in the opinion of the investigator, absence of any physical limitations, addictive diseases, or underlying medical conditions (including mental health) that may preclude the patient from being a suitable study candidate. 9. written informed consent to participate in the study provided by the patient. 10. willing and capable of use of a continuous glucose monitor as judged by the investigator exclusion criteria: 1. type 1 diabetes 2. currently pregnant, as demonstrated by a positive pregnancy test at screening or planning pregnancy 3. treatment with glp-1 ra or insulin degludec in the past three months 4. any active acute or chronic disease or condition that, in the opinion of the investigator, might interfere with the performance of this study. 5. any active acute or chronic infectious disease that, in the opinion of the investigator, would pose an excessive risk to study staff. 6. current use or recent exposure to any medication that in the opinion of the investigator could have an influence on the patient's ability to participate in this study or on the performance of the test device. 7. extensive skin changes/diseases that preclude wearing the cgm on normal skin at the proposed application sites (e.g., extensive psoriasis, recent burns or severe sunburn, extensive eczema, extensive scarring, extensive tattoos, dermatitis herpetiformis). 8. have a known allergy to medical-grade adhesives 9. known current or recent alcohol or drug abuse 10. diabetic ketoacidosis, hyperosmolar hyperglycaemic state or myocardial infarction in the six months prior to screening 11. patients on renal replacement therapy or likely require kidney transplant or dialysis during the study period 12. currently participating in another investigational study protocol where the testing or results may interfere with study compliance, diagnostic results, or data collection. 13. an identified protected vulnerable patient (including but not limited to those in detention, or a prisoner).
study of standard and individualized treatment model for relapse and refractory lymphatic system malignant tumors

Conditions: Lymphoma

Summary: the purpose of the study is to research the standard and individualized treatment model for relapse and refractory lymphatic system malignant tumors.


Eligibility criteria:
inclusion criteria: 1. patients with relapse and refractory lymphoma and multiple myeloma. 2. at least 1 measurable lesions and its size≥15mm. 3. patients ≤65 years，no limitations for both gender. 4. ecog score is 0-1. 5. life expectancy≥3 months. 6. lvef≥ 55%; peripheral blood: wbc ≥ 3.5×10(9)/l,neutrophil ≥1.5×10(9)/l, plt≥75×109/l，hb≥90g/l; renal function: cr≤2.0×unl; liver function: bil≤2.0×unl，alt/ast≤2.5×unl; 7. written informed consent are acquired. exclusion criteria: 1. previously received stem cell transplantation. 2. women with pregnant, lactating or not to take contraceptive measures. 3. severe acute infection or suppurative and chronic infection that wound not healing. 4. severe heart failure. 5. suffering from mental disorders and poor compliance. 6. other situations that investigators consider as contra-indication for this study.
breast cancer registry platform

Conditions: Breast Cancer

Summary: the purpose of the project is to set up a national, prospective, longitudinal, multicenter cohort study with associated satellites, a tumor registry platform, to document uniform data on characteristics, molecular diagnostics, treatment and course of disease, to collect patient-reported outcomes and to establish a decentralized biobank for patients with breast cancer in germany.

opal is a national, observational, prospective, longitudinal, multicenter cohort study (tumor registry platform) with the purpose to record information on the antineoplastic treatment of breast cancer in germany. the registry will follow patients for up to five years. it will identify common therapeutic sequences and changes in the treatment of the disease. at inclusion, data in patient characteristics, comorbidities, tumor characteristics and previous treatments are collected. during the course of observation data on all systemic treatments, radiotherapies, surgeries, and outcome are documented. health-related quality of life in patients with breast cancer will be evaluated for up to five years.

Eligibility criteria:
inclusion criteria: ebc cohort: * female and male patients with early breast cancer (stage i-iii defined as breast cancer that has not spread beyond the breast or the axillary lymph nodes) * patients at the start of their initial systemic treatment for ebc, i.e. at start of neoadjuvant treatment for patients receiving neoadjuvant thera-py or at start of adjuvant treatment if no neoadjuvant therapy is given. treatment can be cytotoxic, endocrine, or targeted substances, what-ever was given first abc cohort: * female and male patients with advanced breast cancer (stage iv defined as synchronous or metachronous diagnosis of distant metastases at inclusion) * patients at the start of their initial first-line systemic treatment for abc, which can be cytotoxic, endocrine or targeting a specific signaling pathway, whatever is given first all cohorts: * written informed consent * patients participating in the pro module: signing of informed consent form and completion of baseline questionnaire before start of initial systemic treatment for ebc or systemic first-line treatment for abc * patients not participating in the pro module: within six weeks after start of initial systemic treatment for ebc or systemic first-line treatment for abc * age ≥ 18 years exclusion criteria: * patients with prior systemic therapy (cytotoxic, endocrine, or targeted) for ebc or abc * patients who do not receive any systemic therapy for ebc or abc

Keywords: breast cancer epidemiology registry health services research germany palliative treatment adjuvant treatment neoadjuvant treatment
oagb-mgb conversions for post-operative complications

Conditions: Bariatric Surgery Candidate

Summary: laparoscopic mini/one anastomosis gastric bypass (mgb/oagb) is a relatively new bariatric procedure and is gaining ground over the surgical approach for morbid obesity as a safe and effective operation. revision of mgb/oagb was never studied before as multicenter data collection: we collected data from 21 italian centers who perform mgb/oagb to evaluate patients' conditions which determinated the conversion from this procedure to another kind of bariatric technique.

mgb / oagb has been shown to be an effective and safe bariatric technique. despite that, the complications of this procedure have already been extensively described in the literature. our goal is to collect data from 21 italian centers that practice mgb / oagb to evaluate the reasons and complications that led surgeons to revise this surgery with a subsequent bariatric procedure. for this reason we have analyzed the data provided by the centers on 8676 patients undergoing mgb / oagb, focusing attention on phenomena such as gerd, anastomotic stenosis, bleeding and marginal ulcers which are the most frequent causes of re-intervention. we also evaluated the changes in bmi between the primary procedure and the revision procedure to ensure that the bariatric purpose of the surgical program was maintained.

Eligibility criteria:
inclusion criteria: * patients underwent to oagb-mgb who needed conversion to other bariatric procedure exclusion criteria: * patients underwent to oagb-mgb who needed conversion to other bariatric procedure in emergency within 48/72 hours after the first surgery
calcium absorption in postmenopausal thai women

Conditions: Fractional Calcium Absorption

Summary: adequate calcium absorption is essential for reducing one's risk of developing osteoporosis. however, postmenopausal thai women consume diets which are habitually low in calcium due to lactose intolerance and dietary patterns which typically do not include milk-based products. the primary goal of this study is to measure the fractional calcium absorption from milk and a commonly ingested green leafy vegetable (cassia) in postmenopausal thai women with habitually low calcium intakes. the secondary objective is to determine associations between calcium absorption and biomarkers which impact vitamin d status and bone metabolism.

postmenopausal thai women (n=22) will be recruited from the community surrounding bangkok and nakhon pathon, thailand. they will be invited to participate in an isotope study comparing the fractional calcium absorption from milk and cassia. upon arrival, a fasting blood sample will be drawn on the morning of the absorption study to analyze serum markers of vitamin d and bone metabolism (25-hydroxy vitamin d \[25ohd\], parathyroid hormone \[pth\], and beta-crosslaps) and to determine their impact on calcium absorption. following this blood draw, women will receive a stable calcium isotope (42ca) intravenously. then for breakfast and lunch respectively, the women will be randomly assigned to orally ingest a stable calcium isotope from either the milk (44ca) or cassia (43ca) test meals. on day two, women will receive a breakfast, snack, and lunch meal. urine samples will be collected over the entire 28 hour period and the 24-hr urine collection will be used to measure urinary calcium concentration and to calculate fractional calcium absorption.

Eligibility criteria:
inclusion criteria: * healthy * at least 3 years postmenopausal exclusion criteria: * diagnosed gastrointestinal or metabolic diseases known to interfere with calcium absorption and metabolism * women taking medications (including thiazide diuretics, hormonal replacement therapy, etc.) within two months prior to the study * women taking dietary supplements within two months prior to the study

Keywords: triple stable isotope
sbrt vs. conventional fractionation with hdr boost for prostate cancer

Conditions: Prostate Cancer

Summary: random assignment between sbrt and conventionally fractionated boost following hdr brachytherapy for prostate cancer.

many treatment options exist for prostate cancer. one common treatment approach is to combine high-dose rate (hdr) brachytherapy (temporary insertion of radiation into the prostate) and external beam radiation. external beam radiation typically requires daily radiation treatment for three to five weeks. improvements to radiation planning and delivery has allowed stereotactic body radiation therapy (sbrt) to be implemented in many types of cancer. sbrt has been implemented as a standard treatment option after hdr brachytherapy in response to the covid pandemic. we are seeking to evaluate whether it is feasible to randomly assign men between sbrt (which will be five treatments of radiation or conventional radiation (3-5 weeks of daily treatment) following hdr brachytherapy

Eligibility criteria:
inclusion criteria: * age 18 or older * informed consent for treatment and study participation completed * pathologically proven diagnosis of prostate adenocarcinoma * ecog performance status 0-2 * no prior history of pelvic radiotherapy, brachytherapy, cryosurgery, hifu, turp or radical prostatectomy exclusion criteria: * presence of nodal or distant metastasis on staging mri or ct abdomen/pelvis and bone scan within 90 days of enrolment (ct/mri/bone scan are only required if the clinical risk of metastatic disease is sufficient to warrant these scans) * plan for adjuvant chemotherapy post-radiotherapy * serious medical comorbidities or other contraindications to hdr brachytherapy * presence of inflammatory bowel disease * presence of connective tissue disorder seen as a contraindication to radiotherapy * medically unfit for general/spinal anesthesia * unable or unwilling to complete questionnaires