Kornimate/medical-research-clean huggingface dataset:
methylene blue spray for identification of recurrent laryngeal nerve and parathyroid gland

Conditions: Methylene Blue; Recurrent Laryngeal Nerve Injuries; Parathyroid Gland

Summary: thyroidectomy is the procedure by which surgeons treat various thyroid diseases and is considered the commonest endocrinal surgery. yet, it carries a risk for intraoperative complications. the most distressing complications are recurrent laryngeal nerve and parathyroid injuries. methylene blue spray is a technique than can be used for easy identification of both recurrent laryngeal nerve and parathyroid glands so we can avoid their injuries.

thyroid disorders constitute the second most common endocrine disease following diabetes mellitus. thyroid surgery is one of the most frequently operated head and neck surgeries. post-thyroidectomy complications are not uncommon. parathyroids and recurrent laryngeal nerve (rln) are two of the complications of thyroidectomy that cause significant postoperative morbidity due to the advances in thyroids surgeries, the occurrence of postoperative complications has been decreased, but when occurred, they cause lifelong handicap. the most important complications encountered are injury to the rln and parathyroids. meticulous dissection is a key factor in minimizing the occurrence of complications during thyroidectomy, careful dissection can protect the parathyroid glands and rln. various methods were used including capsular dissection, attention to protection of the arterial supply to parathyroids, avoiding unnecessary manipulation in the area of rln methylene blue spraying is a new technique that allows identification of both parathyroid glands and recurrent laryngeal nerves

Eligibility criteria:
inclusion criteria: * age of 16 years and older. * both sexes. * patients who are candidate for thyroid surgery and euthyroid. exclusion criteria: * - patients with hyper- or hypo-thyroid status. * patients who were unfit for surgery. * patients with unilateral or bilateral vocal cord palsy on preoperative indirect laryngoscopy * patients with thyroid malignancy by preoperative fnac. * patients with hypersensitivity to methylene blue were excluded.
effect of music therapy on postoperative health outcomes

Conditions: Music Therapy

Summary: patients underwent surgical procedure experiences acute postoperative pain, but less than half report adequate postoperative pain relief. the poor management of pain after surgery is associated with inadequate sleep and poor mood. music therapy is described as a non-pharmacological technique to accomplish individualized patient's goals for hospital treatment. music has been used as a healing approach. in saudi arabia, there is a lack of evidence related to the effect of music therapy on pain and sleep among patients who underwent abdominal surgery. studies are needed to address additional aspects of pain management and the promotion of sleep among saudi adult postoperative people by using non-pharmacological modalities.

aim: the study will investigate the effect of music therapy on acute postoperative pain and sleep quality among patients undergoing abdominal surgery. a randomized control trial design will be demonstrated to accomplish this study. a total sample of 60 cases who underwent general abdominal surgery will be recruited. the study will be carried on in general surgery wards in one of a university hospitals in riyadh city, ksa. four tools will be used to collect the data: socio-demographic and medical data sheet, pain numeric rating scale (pnrs) for pain, insomnia severity index (isi) and opinions questions regarding music therapy. the intervention group will listen to the selected prerecorded music on individual cd players by using a headset for consecutive three days. music therapy will be given for 30 minutes during day time; depends upon the analgesics peak action time to avoid the bias of the intervention. once again, it will be played before bedtime.

Eligibility criteria:
inclusion criteria: patients who will meet the following criteria will be eligible to participate in this study: * adult patients, including both sexes and aged between18-60 years. * had an abdominal surgery. * give informed consent and are hemodynamically stabilized. * willing to receive music therapy for three consecutive postoperative days by using headset. exclusion criteria: * patients will be ineligible to participate in this study if they have any of the following: * hearing deficit. * history of chronic pain. * metastasis cancer, on narcotic medication. * dementia, or psychiatric diagnosis

Keywords: music therapy pain sleep quality abdominal surgery
immune system modulation and outcome in high-risk cscc treated with surgery and radiotherapy

Conditions: Squamous Cell Carcinoma of the Skin

Summary: treatment with adjuvant radiotherapy modulates immune system in many diseases as witnessed by dynamic changes of humoral and cellular immunity. moreover, the persistent lymphopenia after radiation therapy is a negative prognostic factor. this study is aimed to explore the changes in immune-cell populations during radiotherapy given as adjuvant treatment for high-risk cutaneous squamous cell carcinomas and to correlate them with patient's outcome.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * signed written informed consent. * histologically confirmed diagnosis of cscc. * cscc categorized as high risk according to astro guidelines: * close or positive margins that cannot be corrected with further surgery (secondary to morbidity or adverse cosmetic outcome). * gross perineural spread, as identified by radiological or pathological assessment. * disease recurrence after a prior margin-negative resection. * pathological stage t3 and t4. * desmoplastic or infiltrative tumors in the setting of chronic immunosuppression at pathological exam, cscc involving regional lymphnodes, with the exception of a single, small (\<3 cm) cervical lymph node harboring carcinoma, without extracapsular extension. * cscc addressed to adjuvant radiotherapy as per clinical practice (a complete post-operative treatment should be administered with 50-54 or 60-66 gy depending on the margin status). * eastern cooperative oncology group (ecog) performance status of 0-2. exclusion criteria: * cscc not eligible for surgery. * cscc not eligible for adjuvant radiotherapy for any condition depending on disease characteristics or patient characteristics, co-morbidities or refusal. * any concurrent investigational product, biologic, or hormonal therapy for cancer treatment. * concurrent treatment with chemotherapy for the purpose of cscc cure. * history or current evidence of any condition that, in the opinion of the treating investigator, might interfere with the subject's participation for the full duration of the trial. * any major surgery, different from that planned for the protocol, in the 15 days before the protocol starting. * any radiotherapy treatment in the 28 days before the protocol starting * pregnant or breastfeeding.
reversal of type 1 diabetes in children by stem cell educator therapy

Conditions: Type 1 Diabetes

Summary: type 1 diabetes (t1d) is an autoimmune disease that usually occurs in children and reduces their pancreatic islet beta cells and thereby limits insulin production. millions of individuals worldwide have t1d, and the number of children with diagnosed or undiagnosed t1d is increasing annually. insulin supplementation is not a cure. it does not halt the persistent autoimmune response, nor can it reliably prevent devastating complications such as neuronal and cardiovascular diseases, blindness, and kidney failure. a true cure has proven elusive despite intensive research pressure over the past 25 years. notably, dr.zhao and his team have successfully developed a groundbreaking technology stem cell educator therapy (zhao y, et al.bmc medicine 2011, 2012). to date, clinical trials in adult patients have demonstrated the safety and efficacy of stem cell educator therapy for the treatment of t1d and other autoimmune-associated diseases. here, the investigators will evaluate the safety and efficacy of stem cell educator therapy in children with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * 1. t1d patients are screened for enrollment in the study if both clinical signs and laboratory tests meet the diagnosis standards of american diabetes association. 2. children from 3 through 18 years old and body weight \> 15 kg. 3. presence of at least one autoantibody to the pancreatic islet β cells (ia-2, gad, ica, znt8, or iaa). 4. written informed consent from the child and child's parents or legal representative. exclusion criteria: * 1. any clinically significant diseases in liver, kidney, and heart. 2. additional exclusion criteria include no immunosuppressive medication, no viral diseases or diseases associated with immunodeficiency 3. significantly abnormal hematology results at screening. 4. presence of any infection diseases or inflammation conditions, including active skin infections, flu, fever, upper or lower respiratory track infections.

Keywords: type 1 diabetes autoimmune cord blood stem cell stem cell educator immune modulation children control autoimmunity stimulate the regeneration of islet beta cells
real-time glaucoma medication adherence

Conditions: Glaucoma

Summary: this study will evaluate the effectiveness of real-time data collected on patients taking topical medication to treat glaucoma. patients will be randomized to two groups, the first of which will only use the study device to take their medication, while the second will use the study device and receive on-demand reminder messages, when necessary.

adherence to topical medications to treat glaucoma remains sub optimal; however, our understanding of this behavior remains limited due to biased measures of medication use. the kali drop device is a potential improvement in our ability to capture medication use in patients using dropper bottles by precisely capturing the amount dispensed in real-time. moreover, such technology creates data that can be leveraged into driving behavior change using connected mobile technology in order to improve adherence and, ultimately, health outcomes. while evidence suggests that reminders may improve adherence to glaucoma medications, the power of doing so using real-time data has yet to be explored. this study will compare simple monitoring of patients to those who are being monitored and who receive reminder messages when the system determines one is necessary due to a missed dose.

Eligibility criteria:
inclusion criteria: * 18 years of age and older * glaucoma diagnosis * prescription for a prostaglandin indicated for glaucoma * nonadherent (mpr\<80%) in the last 3 months according to pharmacy records * owns and operates a mobile phone and willing to receive periodic reminder messages exclusion criteria: * existing chronic eye condition in addition to glaucoma * scheduled for eye surgery in the next 90 days * prescription for a medication that will not fit in the device * non-english speaking

Keywords: adherence mobile health real-time data
effect of creon on exocrine pancreatic insufficiency (epi) symptoms

Conditions: Chronic Pancreatitis

Summary: exocrine pancreatic insufficiency (epi) is a condition where pancreatic enzyme quantity or activity is reduced below threshold needed for normal digestion. symptoms include bloating, flatulence, diarrhea and steatorrhea. this is an observational study assessing for effect of creon on symptoms of epi in participants with epi due to chronic pancreatitis.


Eligibility criteria:
inclusion criteria: * medical history of chronic pancreatitis (cp). * diagnosis of exocrine pancreatic insufficiency (epi). exclusion criteria: --history of cystic fibrosis, pancreatic cancer, pancreatic surgery, gastric bypass surgery, extensive bowel surgery, inflammatory bowel disease, celiac disease, irritable bowel syndrome

Keywords: chronic pancreatitis exocrine pancreatic insufficiency creon pancrelipase abt-slv245
the cardiovascular protective effects of febuxostat in peritoneal dialysis patients

Conditions: Disorders Associated With Peritoneal Dialysis; Hyperuricemia

Summary: the purpose of this study is to determine whether febuxostat could protect cardiovascular function of peritoneal dialysis patients by lowering serum uric acid.

patients with more than 3-month-history of peritoneal dialysis and hyperuricemia. use febuxostat to control their serum uric acid for 1 year. to observe the cardiovascular events of patients, and compare and evaluate the changes of heart function, heart construction, serum cardiac markers and brain natriuretic peptide (bnp) levels before and after febuxostat treatment.

Eligibility criteria:
inclusion criteria: - peritoneal dialysis for more than 3 months with hyperuricemia. exclusion criteria: 1. acute hepatopathy or liver dysfunction (aspartate transaminase and/or alanine aminotransferase exceed 2 times of normal range) 2. heart failure (stage iv, nyha), unstable angina, acute stroke 3. severe lung disease or cancer 4. unable to sign the informed consent form or disagree following-up.

Keywords: peritoneal dialysis hyperuricemia cardiovascular febuxostat
umbilical cord mesenchymal stem cells infusion for ulcerative colitis

Conditions: Ulcerative Colitis; Mesenchymal Stem Cells; Umbilical Cord

Summary: the purpose of this study is to determine whether umbilical cord mesenchymal stem cells of treatment for ulcerative colitis is safe and effective.

ulcerative colitis is characterized as chronic and nonspecific inflammation of gastroenteritis tract．nowadays，etiology and pathogenesis of uc have been unclear．recent basic research has been revealed that stem cell can settle down in epithelium of gastroenteritis tract，which provide a hope for treating the disease.we hope umbilical cord mesenchymal stem cells could not only address the need for epithelial cell replacement but also control of the autoimmune response to mocous membrane of colon.

Eligibility criteria:
inclusion criteria: * male or female, 18 years of age or older. * ulcerative colitis described according to usual criteria. * refractoriness ulcerative colitis or unefficient by using other therapy * signed informed consent form. exclusion criteria: * history of neoplasm or hematological disease * uncontrolled high blood pressure (\>180/110) * severe cardiac insufficiency (new york heart association \[nyha\] iv) or ejection fraction\<30% * malignant ventricular arrythmia * deep venous thrombosis during the last 3 months * active bacterial infection * body mass index \> 35 kg/m2 * stroke or myocardial infarction during the last 3 months

Keywords: ulcerative colitis mesenchymal stem cells umbilical cord
progression of damage in ulcerative colitis

Conditions: Ulcerative Colitis

Summary: the hypothesis of the study is that in ulcerative colitis repeated flares of inflammatory activity, as well as mechanisms involved in resolution of the inflammatory response, may contribute to accumulation of damage in the colon leading to functional disturbances and symptoms that affect patient's functioning. the primary objective is to determine whether ulcerative colitis induces permanent anatomical damage, by means of magnetic resonance imaging.


Eligibility criteria:
inclusion criteria: * patients of both sexes aged \>18 years and \<72 years. * ulcerative colitis diagnosed according to european crohn's and colitis organization guidelines . * ulcerative colitis in endoscopic remission as demonstrated by a recto-sigmoidoscopy/colonoscopy (defined as: mayo endoscopic score 0-1; ulcerative colitis endoscopic index of severity : bleeding 0, vascular 0-1, erosion/ulcers 0). * normal c-reactive protein according local laboratory values. * informed consent for participation. * understands the language of the provided patient questionnaires. exclusion criteria: * pregnant women (or pregnancy suspected). * previous colonic surgery. * patients receiving corticosteroids or antidiarrheal medications. * patients with suspected or confirmed active gastrointestinal infection. * patients with a diagnosis of other gastrointestinal disorders that may result in symptoms including, but not limited to, celiac disease, intolerance to disaccharides and pancreatic disorders. * diabetes. * thyroid disorders. * liver disease. * any other systemic disease that, according to the investigator's criteria, might influence the variables investigated. * patients with history of colonic dysplasia.
effect of tyg index on outcomes of radical prostatectomy

Conditions: Metabolic Syndrome; Prostate Cancer; Insulin Resistance

Summary: we investigate the association between triglyserid-glucose(tyg) index and prostate cancer in patients undergoing radical prostatectomy.

tyg index is calculated with special formula. patients undergoing radical prostatectomy are divided two groups according to the cut-off level of 8.55 for tyg index.groups were compared statistically in terms of oncological outcomes and survival.

Eligibility criteria:
inclusion criteria: * patients undergoing radical prostatectomy for prostate cancer exclusion criteria: * taking medicines for established diabetes and dyslipidaemia, * presence of endocrinological disease, * history of bariatric surgery, * missing data and patients with uncontrolled follow-up

Keywords: triglyseride-glucose index prostate cancer radical prostatectomy metabolic syndrome
a peer-based mobile-health intervention to increase access & adherence to hepatitis c treatment & hiv viral suppression

Conditions: Hepatitis C; HIV; Risk Reduction Behavior

Summary: the purpose of this study is to test an intervention designed to train persons who inject drugs (pwid) and are infected with hepatitis c (hcv) and hiv in communication skills to 1) promote new hcv treatment and care 2) risk reduction and 3) recruit their social network members for hiv and hcv testing and linkage to care.

the investigators propose recruiting 300 hiv/hcv co-infected pwid (i.e. index participants). half will be randomly assigned to the experimental condition and half to the equal attention comparison. the experimental intervention will include 8 group sessions that focus on communication to social network members, medical adherence and risk reduction skills, 2 dyad sessions with network members, monthly booster sessions for 6 months, and mhealth cuing of behavior for 6 months. these index participants will be followed for 24 months (3, 6, 12, 18, \& 24 month assessments). participants who test positive for hcv will be linked to the johns hopkins viral hepatitis clinic to assess liver function and hcv chronicity and if applicable offered hcv treatment. additionally, 450 network members will be recruited and will be tested for hiv and hcv and followed longitudinally to examine the social diffusion and social network factors associated with adherence among the index participants.

Eligibility criteria:
inclusion criteria: * hcv antibody positive * hiv antibody positive * lifetime history of injection drug use * interrupted hiv care:\>3 months since hiv care or detectable viral load * willingness to participate in group sessions and have conversations with social network members exclusion criteria: - participated in a behavioral intervention in prior 2 years

Keywords: testing access
alloplastic total temporomandibular joint (tmj) replacement registry

Conditions: Temporomandibular Joint Disorders

Summary: prospective data will be collected in approximately 200 patients treated with an tmj replacement. patients will be followed up according to the standard (routine) for up to 5 years after the treatment. data collection will include underlying disease, treatment details, functional and patient reported outcomes (pro)s and anticipated or procedure-related adverse events (i.e. complications). this registry is designed to be able to assess the number of patients who refuse alloplastic total tmj replacement. therefore, the participating sites are asked to register all cases of refused tmj replacements too.

more in detail this registry has the following objectives: * to describe clinical indications for tmj replacement, and treatment patterns (including differences among regions if feasible) * to describe the clinical evolution and outcomes of patients treated with a tmj replacement * to explore the relationship(s) between treatment, outcome(s) and quality of life (qol). * to identify predictive factors for favorable outcomes (pain reduction, range of motion (rom), occlusal status, qol) in patients treated with tmj replacement. * to describe the reasons of patients who refused tmj replacements

Eligibility criteria:
inclusion criteria: * age 18 years and or older * patients requiring alloplastic total tmj replacement * informed consent obtained, i.e.: * ability to understand the content of the patient information/informed consent form (icf) * willingness and ability to participate in the registry according to the registry plan (rp) * signed and dated ethics committee (ec) / institutional review board (irb) approved written informed consent exclusion criteria: * recent history of substance abuse (i.e. recreational drugs, alcohol) that would preclude reliable assessment * pregnancy or women planning to conceive within the study period * participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study

Keywords: temporomandibular joint tmj replacement trauma ankylosis degenerative joint disease registry
review on minimally invasive skin incision in vanguard ps artificial knee joint system

Conditions: Gonarthrosis Patients Who Need Artificial Knee Joint Total Replacement

Summary: this study will show whether tri-vector method can ensure more extensive visual field and conduct the precise surgery when compared with mini mid-vastus method by conducting 2 types of skin incision approach, tri-vector for 36 patients or mini-mid vastus for 36 patients in vanguard ps artificial knee joint total replacement observational period before and during surgery.


Eligibility criteria:
inclusion criteria: * the patients who need artificial knee joint replacement in ordinary medical consultation are selected as the subjects. exclusion criteria: * patients with infections such as osteomyelitis, or sepsis (because the affected part is lesioned, excellent surgical results cannot be obtained.)