Kornimate/medical-research-clean huggingface dataset:
effects of bioelectric stimulation in patients with non-dialysis dependent chronic kidney disease

Conditions: Renal Insufficiency, Chronic; Electric Stimulation

Summary: chronic kidney disease (ckd) consists of kidney damage, with a consequent progressive and irreversible loss of kidney function. in the early stages of the disease, there is already a reduction in circulating levels of α-klotho protein, which is related to worsening renal function. therapeutic strategies that increase serum α-klotho levels can be of great value in the treatment of ckd. electrical stimulation contributes to the reduction of reactive oxygen species, dna damage and improves the efficiency rate of dialysis, suggesting a systemic effect in patients with end-stage ckd. the aim of this study is to evaluate the effects of bioelectric stimulation on renal function and physical capacity in patients with ckd. for this, patients will be randomized into bioelectric stimulation or a control group. bioelectric stimulation will be performed three times a week for eight weeks. the control group will only be evaluated and re-evaluated. the following pre-and post-intervention assessments will be performed: analysis of the plasma content of α-klotho and soluble creatinine to assess renal function, six-minute walk test to assess functional capacity; dosage of interleukins and tumor necrosis factor to analyze the inflammatory profile; sit and stand test with 10 repetitions and load cell dynamometry to assess lower limb muscle strength and application of the euroqol-5d questionnaire for quality of life. biochemical analyzes for renal function and inflammatory profile will also be performed after four weeks of follow-up.


Eligibility criteria:
inclusion criteria: * age 18-80 years of age; * ckd with glomerular filtration rate (gfr) between 15-59 ml/min (iii and iv stage of ckd) for more than 3 months; * to be able to ambulate \> 300 meters in 6 minutes walk test. exclusion criteria: * cognitive dysfunction that prevents the performance of evaluations, as well as an inability to understand and sign the informed consent form; * intolerance to the electrostimulator and/or alteration of skin sensitivity; * skin lesions/burns at the electrode placement site; * patients with stroke in past 6 months with residual limitation to ambulation; * disabling musculoskeletal disease; * uncontrolled hypertension (systolic blood pressure \> 230 mmhg and diastolic blood pressure \> 120 mmhg); * grade iii or iv heart failure (nyha); * patient with a pacemaker; * uncontrolled diabetes (fasting blood glucose \> 250 mg/dl); * unstable angina; * coronary stent placement in past 3 months; * recent acute myocardial infarction (two months); * fever and/or infectious disease; * peripheral vascular disease in the lower limbs that limits ambulation or deep vein thrombosis; * chronic obstructive lung disease that limits ambulation or need for oxygen therapy; * obesity (body mass index≥35); * patient with active cancer.
the cyclocapnic method for measurement of chemosensitivity

Conditions: Periodic Breathing; Heart Failure

Summary: we aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli. hypotheses: * carbon dioxide sensitivity is dependent on the cycle time over which we administer the gas (frequency). * chemoreflex gain decreases as deadspace increases.

we will apply a new method for the measurement of chemosensitivity (how sensitive a person is to changes in carbon dioxide), which is one of the principle determinants of whether people with heart failure develop abnormal breathing patterns we have shown in a pilot study that administering sinusoidal patterns of inspired carbon dioxide produces similar sinusoidal responses in ventilation. we aim to test our method for measuring chemosensitivity, which uses sinusoidal carbon dioxide stimuli (similar to those that drive the oscillations in ventilation found in periodic breathing). we aim to show that how the cycle time of carbon dioxide administered affects the resulting ventilatory oscillations and therefore that when measuring the chemoreflex clinically, it is important to deliver carbon dioxide stimuli that replicate the cycle time of oscillations in carbon dioxide seen in periodic breathing (typically approximately one minute).

Eligibility criteria:
inclusion criteria: * heart failure subjects with stable cardiorespiratory control to be recruited from our institution's specialist heart failure clinic. * normal healthy volunteers, with normal systolic function. exclusion criteria: * we will exclude patients with chronic respiratory disease (every patient will have formal lung function testing on entrance into the study) or unstable coronary artery disease (myocardial infarction or unstable angina within the past 3 months). * in addition any subjects receiving treatment with morphine and derivatives, theophylline, oxygen, benzodiazepines or acetazolamide will be excluded as these affect chemosensitivity.

Keywords: periodic breathing heart failure chemoreflex chemosensitivity
investigation of antipsoriatic effects of uvb-induced synthesis of 1alpha, 25-dihydroxyvitamin d3 (1alpha, 25(oh)2d3, calcitriol)in keratinocytes of psoriatic skin, using cytochrom-p(cyp)inhibitor ketokonazol

Conditions: Psoriasis Vulgaris

Summary: exploration of antipsoriatic effects of uvb-therapy +/- cyp-inhibitor ketokonazol on affected psoriatic skin


Eligibility criteria:
inclusion criteria: * age: 18- 80 * diagnosis of psoriasis vulgaris (mild- middle) * no other current antipsoriatic therapy (systemic/topical) * at least 5 psoriatic areas of 5x5 cm exclusion criteria: * pregnancy/nursing mothers * women in reproductive age without adequate contraception * severe and acute forms of psoriasis vulgaris * patients receiving systemic or topical antipsoroatic treatment in past 3 month * uv-therapy in past 3 month * patients having a positive anamnesis for squamous cell carcinoma, malignant melanoma, basalioma * epilepsy

Keywords: psoriasis vulgaris, vitamin d, uvb-phototherapy, ketokonazol, optical coherence tomography, local pasi, nizoral
ultrasound-guided hydrosalpinx aspiration during egg collection

Conditions: Infertility

Summary: · what we know: hydrosalpinx and ivf about 40% of patients undergoing ivf have tubal disease and in 25%-30% of tubal disease patients there is fluid collection within the tube; hydrosalpinx. the amount of fluid in the hydrosalpinx is known to increase with ovarian stimulation (as in ivf) and often empties into the uterine cavity. fluid from hydrosalpinges has been found to be detrimental to the growth and development of mouse embryos in vitro, and associated with reduced levels of endometrial integrins in vivo. this could be the explanation of the reduced pregnancy rates after ivf in patients with tubal disease and hydrosalpinx compared with those with tubal disease but no hydrosalpinx. this effect was evidence in both fresh and frozen embryo transfer cycles. also there was a significant increase in miscarriage in association with hydrosalpinx. the study aims to answer the question: does ultrasound-guided aspiration of ultrasound diagnosed hydrosalpinx at the time of egg collection improve the pregnancy rate in ivf?

· what we do not know: treatment of hydrosalpinx and ivf several studies in the literature have suggested that the treatment of hydrosalpinx pre-ivf would improve the pregnancy rate to a level similar to tubal disease patients without hydrosalpinx. the treatment modalities explored were salpingectomy, salpingostomy, tubal occlusion and ultrasound-guided aspiration either one month before or at the time of egg collection. all studies reported to date have been retrospective and with poor control design. a prospective randomised controlled trial is needed. all modalities have been associated with a similar improvement in pregnancy rate, but the least invasive modality is ultrasound-guided aspiration at the time of oocyte collection. we propose to conduct a prospective randomised controlled trial to evaluate the effect of ultrasound-guided aspiration (versus no aspiration) of hydrosalpinx at the time of egg collection on the pregnancy rate in ivf.

Eligibility criteria:
inclusion criteria: * healthy women, asa class 1 (normal healthy) or class 2 (with mild systemic disease); * undergoing ivf or icsi and reaching the stage of egg collection; * with ultrasonically diagnosed hydrosalpinx and identifiable during the phase of ovarian stimulation; * giving written informed consent. exclusion criteria: * patients not giving written informed consent; * patients cancelled for poor ovarian response; * ultrasonically diagnosed hydrosalpinx and identifiable for the first time at egg-collection

Keywords: hydrosalpinx/ivf/reproductive outcome. hydrosalpinx
pilot study to detect zika virus in sperm

Conditions: Viruses

Summary: the purpose of this study is to seek the presence of zikv in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa.

since the end of 2015 an epidemic of zika virus (zikv) infections is occurring in the antilles-guyana departments and focuses our attention on zikv and the risk of transmission during assisted reproductive technologies (art). the importance of this epidemic and the presence in mainland of its mosquito vector (aedes albopictus) point out the risk of a geographic extension of this infection. in this context the use of medically assisted procreation leads to several questions when patients are infected. the question surges for patients (women and men) who live in epidemic areas but also for people who return from these regions and many other countries within the epidemic area (principally south and central america) and who need art. information about localization of zikv in the genital tract or shedding is poorly documented. only two case reports detected zikv rna in the semen and a sexual transmission was described. however, there is no data on the duration of the presence of zikv in semen and on localization of zikv in semen compartments (cells, seminal plasma, spermatozoa). the purpose of this study is to seek the presence of zikv in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa. this is a prospective study involving 15 patients, with acute zikv infection and a positive rna detection in blood or/and urines (institut pasteur, pointe-à-pitre). men will give semen, urine and blood specimens 7 days after the beginning of clinical signs and 11, 20, 30, 60 and 90 days after. zikv rna being diagnosed with blood and/or urine sample positive for zikv rna. zikv rna will be detected in seminal plasma, native semen cells and processed spermatozoa. semen sampling and processing will be performed within the art laboratory of the hospital of pointe-à-pitre (guadeloupe) and research of zikv rna in the laboratory of virology of toulouse university hospital. this study will identify the presence or absence of zikv seminal shedding and in case of shedding, verify the efficiency of semen processing to obtain virus free spermatozoa. these results are important to understand the physiopathology of zikv infection and will help to define the management and viral safety procedures during medically assisted procreation in the context of zikv epidemic.

Eligibility criteria:
inclusion criteria: * infection by zika virus in early stage exclusion criteria: * non infected male, * erection problems

Keywords: zyca virus
effects of uremia on brachial plexus electrophysiology and brachial plexus block

Conditions: Electrical Stimulation of Nerves Produces Muscle Reflexes

Summary: as a late stage of renal failure, uremia not only leads to severe impairment of renal function in patients, but also often leads to a variety of complications, among which multiple peripheral neuropathy is particularly common. this lesion is mainly caused by the combination of multiple mechanisms, such as the accumulation of uremic toxins, electrolyte disorder, nutrient deficiency and factors related to hemodialysis. therefore, it is important clinical significance to deeply explore the effects of uremia on electrophysiological properties and nerve block of brachial plexus. at present, there are relatively few studies on the effects of uremia on the brachial plexus, especially the prospective parallel cohort studies on its electrophysiological properties and nerve block. as a new anesthetic technique, ultrasound-guided axillary brachial plexus block has the advantages of precise positioning, scientific administration, reducing complications and improved safety, but the application effect and safety in uremic patients still need to be further verified.


Eligibility criteria:
inclusion criteria: * uremia group \[group u\] 1. patients aged 18 years and older 2. asa classification i-iv 3. bmi 18.5-29.9 4. patients with uremia planning to undergo forearm or hand surgery 5. diagnostic criteria: patients must meet the internationally recognized diagnostic criteria for uremia and require hemodialysis 6. informed consent: patients or their legal representatives must sign an informed consent form, agreeing to participate in this study and undergo related examinations and treatments * non-uremia group \[group n\] 1. patients aged 18 years and older 2. asa classification i-iv 3. bmi 18.5-29.9 4. patients planning to undergo forearm or hand surgery 5. in addition to possibly having diabetes, patients should not have any other diseases that could cause peripheral neuropathy 6. the patient or their legal representative must sign an informed consent form, agreeing to participate in this study and receive the relevant examinations and treatments exclusion criteria: * individuals allergic to study medications (such as ropivacaine) * those with contraindications to local anesthesia or nerve blockades, such as coagulation disorders, infections, etc. * those with severe cardiovascular or respiratory diseases * those unable to comply with study requirements, such as cognitive impairment, mental disorders, etc. * pregnant women

Keywords: neuron muscle movement electrical stimulation electric current
conditioning regimen containing melphalan and cladribine for refractory / relapsed aml

Conditions: Acute Myeloid Leukemia

Summary: this project is a prospective, multicenter, randomized controlled clinical study. the subjects were refractory / relapsed aml patients aged ≤ 60 years diagnosed by bone marrow cell morphology, immunology, genetics and therapeutic efficacy evaluation. the classical bu / cy scheme or mcbc scheme was used for pretreatment. the primary endpoint of the study was the 3-year recurrence-free survival rate after allogeneic hematopoietic stem cell transplantation, and the secondary endpoints were 3-year overall survival rate, recurrence rate, treatment-related mortality, and pretreatment-related toxicity.


Eligibility criteria:
inclusion criteria: * refractory / relapsed aml. * patients with a hla matched related or unrelated donor (9\~10/10) or haplo-identical related donor, plan to receive hsct. * age ≤ 60 years old, men and women are not limited. * the eastern oncology collaborative group physical status assessment ( ecog-ps ) was 0-2 points. * informed consent must be signed before the start of the study procedure. informed consent must be signed by the patient or his or her immediate family members who are 18 years of age or older ; informed consent was signed by the legal guardian for children and adolescent patients under 18 years old. considering the patient 's condition, if the patient 's signature is not conducive to the treatment of the disease, the informed consent is signed by the legal guardian or the patient 's immediate family. exclusion criteria: * have a history of cancer and have received any treatment for this tumor in the past 3 years. but remove superficial bladder cancer, skin basal cells or squamous cell carcinoma, cervical epithelium. intraepithelial neoplasia ( cin ) or prostatic intraepithelial neoplasia ( pin ). * mpal. * it is known that the serological reaction of hiv or active hepatitis c virus is positive. * the inability to cooperate with the requirements of research, treatment and monitoring due to mental illness or other conditions. * pregnant patients or patients who could not take appropriate contraceptive measures during treatment. * previously received hematopoietic stem cell transplantation. * active heart disease, defined as one or more of the following : 1. ) uncontrolled or symptomatic angina history. 2. ) myocardial infarction less than 6 months away from the study. 3. ) have a history of arrhythmia requiring drug treatment or severe clinical symptoms. 4. ) uncontrolled or symptomatic congestive heart failure ( \> nyha class 2 ). 5. ) the ejection fraction is lower than the lower limit of the normal range. * researchers evaluated that is not suitable for the group.
effect of domperidone on qt interval in premature infants

Conditions: Prematurity and Feeding Intolerance

Summary: 30 premature infants treated by domperidone upon decision of the attending neonatologist will have a daily recording of electrocardiogram for the first 7 seven days of treatment, and pharmacokinetics dosages at day 7. their ecg will be compared to 30 non treated premature infants, matched for gestational age, postnatal age and sex.


Eligibility criteria:
inclusion criteria: gestational age less than 36 weekspostnatal age greater than 10 days treated / not treated by domperidone (case/control)signed parental informed consent exclusion criteria: severe cardiac arrhythmia congenital heart disease (persistent ductus arteriosus excluded)familial history of congenital long qt syndrome

Keywords: domperidone, qt, prematurity
sleep disturbance in deployed soldiers

Conditions: Sleep Disturbance

Summary: hypotheses: * hypothesis 1 - sleep can be measured in theater using actigraph technology. * hypothesis 2 - standard sleep measures in soldiers randomized to a sleep intervention group will more closely approximate normal as compared to sleep measures of soldiers randomized to the control group.


Eligibility criteria:
inclusion criteria: * all study participants must be on active duty, or be reserve or national guard service members notified of impending deployment. * recruited prior to deployment in order to obtain baseline measures before deployment. * have been stateside at least one full year. * able to read and speak english and consent themselves. exclusion criteria: * subjects with self-identified sleep disorder (for example restless leg syndrome or sleep apnea) * pregnancy. pregnant women will be excluded from the study since pregnancy places women in a non-deployable status and pregnant soldiers will not be deploying.

Keywords: sleep disturbance deployment intervention actigraph
distraction for reduction of pain associated with venipuncture in the pediatric post-transplant population

Conditions: Pain, Procedural; Distress, Procedural; Venipuncture

Summary: children with chronic diseases, particularly those who have received transplantation (e.g. cardiac, renal, or liver) are a population who undergo frequent painful procedures, such as venipuncture multiple times per week. there is currently no standard of care for pain reduction during venipuncture for pediatric patients having blood drawn in phlebotomy as an outpatient. the study aims to determine the efficacy of distraction in reducing procedural pain and distress associated with venipuncture in pediatric post-transplant patients.

children with chronic illnesses experience frequent painful experiences over extended periods of time, and may develop long-term physiological, psychological and behavioral sequelae including increased sensitivity to pain and higher levels of anxiety before painful procedures. there is strong evidence to show that distraction is effective in reducing children's pain and distress during painful procedures. however, the evidence to support distraction, as well as other methods of pain reduction during venipuncture (i.e. vibration, topical anesthetics, sucrose), has primarily focused on children who are previously well, as those with chronic disease are an understudied population with regards to pain reduction during simple procedures. children with chronic disease or pathology, particularly those who have received transplantation (e.g. cardiac, renal, liver), are a population who undergo frequent painful procedures, such as venipuncture multiple times per week. there is currently no standard of care for pain reduction during venipuncture for pediatric patients having blood drawn in phlebotomy or in the transplant clinics as an outpatient. the investigators will conduct a randomized control trial comparing two groups: distraction versus standard of care (i.e. no distraction). the intervention (distraction) will be administered using an ipad and allowing the child to self-select a developmentally appropriate distraction (e.g. game, movie, music). participants will be videotaped for approximately 1 minute, starting from the time of the venipuncture. this video will be viewed at a later date by two trained study investigators to assess the patient's pain and distress associated with venipuncture, as measured by the osbd-r, cheops, and flacc.

Eligibility criteria:
inclusion criteria: * history of solid organ transplantation * undergoing venipuncture exclusion criteria: * blood being drawn from a central line

Keywords: phlebotomy pain distress
assessment of right ventricular volume in tetralogy of fallott (tof) patients

Conditions: Tetralogy of Fallot

Summary: assessment of right ventricular volume using the ventripoint medical system in patients with tetralogy of fallot following repair; a comparison study to cmri. the objective of this study is: to evaluate the accuracy of the ventripoint medical system to calculate right ventricular volumes in patients with tetralogy of fallot following surgical repair. secondary objectives are: to validate inter and intra observer variability at 3 clinical sites. the analyses will be the same for edv and esv. for either right ventricular volume, the primary effectiveness measure is the % difference between vms and cmri results, i.e. (vms-cmri)\*100%/average of vms and cmri results. there will be two null hypotheses for the primary analysis: h0+: true mean % difference \> 10% and h0-: true mean % difference \< -10% the observed mean % difference will be presented with 95% confidence intervals. the vms right ventricular volume estimates will be regarded as equivalent to cmri estimates if both h0+ and h0- are rejected at a 1-sided 0.025 level by a paired t test for both edv and esv. since h0+ and h0- cannot both be true, the total type i error rate for each measure is 0.025 and the overall type i error rate for both edv and esv is 0.05.


Eligibility criteria:
inclusion criteria: * patients with tetralogy of fallot following surgical repair * patients who can be expected to lie motionless during imaging exclusion criteria: * lack of informed consent * surgical repair for tetralogy of fallot with rv-pa conduit * known arrhythmia that interferes with image acquisition. * implanted cardiac defibrillator, pacemaker, or other devices containing ferromagnetic materials * pregnant woman * contraindications for mri