Kornimate/medical-research-clean huggingface dataset:
effects on paco2 levels of two different nasal cannula in copd patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: high-flow nasal cannula (hfnc) therapy is increasingly used in the management of acute respiratory failure. its clinical application has been expanded also in other specific settings in stable copd patients and in those recovering from acute exacerbation, hfnc can reduce paco2, respiratory rate, minute ventilation and respiratory effort. the aim of this randomized crossover physiological study is to investigate the effects on paco2 levels of two different nasal cannula ('optiflow + duet' interface vs "standard" nasal interface) in copd patients with persistent hypercapnia following an acute severe exacerbation


Eligibility criteria:
inclusion criteria: * inpatients recovering from an acute exacerbation of their disease * persisting hypercapnia, despite having reached a stabilization in ph (i.e. ph\>7,35 and * paco2\>50 mmhg on 3 consecutive measurements) * informed consent exclusion criteria: * body mass index (bmi) \> 30 kg/m2; * previous diagnosis of obstructive sleep apnea syndrome (osas) * chest wall disease * heart failure * severe hemodynamic instability ( need for amine support) * acute coronary syndrome (acs) * severe arrhythmia * renal insufficiency * patients unable to protect respiratory airways * respiratory arrest and need for endotracheal intubation * pregnancy * need for sedation

Keywords: hfnc hypercapnia copd
human papilloma virus awareness intervention

Conditions: Human Papilloma Virus (HPV)

Summary: intervention aimed at increasing knowledge of the human papillomavirus in homosexual men as a means of preventing sexually transmitted diseases and controlling complications associated with the pathology.

introduction: the world health organization reports a 21% prevalence of human papillomavirus (hpv) in men, with rates reaching 93% among homosexual men. this group exhibits specific characteristics, such as high rates of sexually transmitted infections (stis) due to multiple partners and inconsistent condom use, along with limited knowledge about hpv. the intervention "safe and protected sex", using a horizontal methodology, aims to address this health issue. objective: to evaluate the effect of the "safe and protected sex" program on hpv knowledge among homosexual men. methodology: a quasi-experimental study with a test-retest design and convenience sampling. the sample size was calculated using n'query advisor 4.0, resulting in 20 homosexual men per group (n=40).

Eligibility criteria:
inclusion criteria: * males who self-identify as homosexual and/or bisexual. * engage in sexual relationships with individuals of the same sex. * willing to voluntarily participate in the study. * have provided informed consent. exclusion criteria: * homosexual and/or bisexual males with a profession related to the healthcare field.

Keywords: intervention knowledge homosexual me
optimization of ventilation strategies in preterm and term infants in a single-center intervention study

Conditions: Lung-protective Ventilation; Respiratory Function Monitor

Summary: this study was a non-blinded, non-randomized intervention study in a single-center clinical setting, analyzing ventilation quality with and without rfm visibility.

the study was conducted at the neonatal intensive care unit and the delivery room at the division of neonatology, at the medical university of vienna. we aimed to record ventilation parameters (tidal volume, mask leak, ventilation rate, pip, peep) using a ce-certified respiratory function monitor (neo100, monivent ab, gothenburg, sweden), which was either hidden or visible to the provider responsible for the airway (airway provider), during ventilations on term and preterm patients at the nicu and the delivery room. the investigators aimed to determine the quality of ventilations performed by healthcare professionals depending on rfm visibility. analysis occurred, determining whether observing the data displayed on the rfm during ppv of preterm and newborn infants lead to adjustments in applied pressure and an increase in the proportion of inflations performed within a predefined range of 4-8 ml/kg for vte. the investigators hypothesized that using a rfm with numeric and graphical display of values during positive pressure ventilation of infants will lead to i) more frequent recognition and correction of tidal volumes outside the predefined range and ii) reduction of mask leak. this knowledge gain may improve future training using a rfm to improve the quality of ventilations and, thereby, patient safety.

Eligibility criteria:
inclusion criteria: * patients at the neonatal intensive care unit (nicu) and in the delivery room who receive positive pressure ventilation * written consent from parents or legal guardians of patients * preterm and term infants (male and female, any gestational age) exclusion criteria: - healthcare professionals or parents/legal guardians, representing their children, that do not consent to participation in this study
intrabone transplantation of allogenic peripheral blood stem cells in patients with myeloid and lymphoid malignancies.

Conditions: Leukemia; Lymphoma

Summary: the purpose of the study is to evaluate efficacy and safety of direct intrabone transplantation procedure of peripheral blood haematopoietic stem cells form hla-matched sibling donors in patients with myeloid and lymphoid malignancies.

allogenic haematopoietic stem cell transplantation is an established treatment option for haematologic malignancies, especially leukaemias and lymphomas, providing curative potential. the optimal donor is hla-matched sibling and g-csf stimulated peripheral blood is nowadays the most common source of stem cells. routinely used route of stem cell transplantation is intravenous infusion via central venous catheter. based on the animal studies, only 10-15% of intravenously transplanted stem cells migrate to haematopoietic sites while the rest is lost in other organs. results of studies of direct intrabone allogenic cord-blood cells transplantation in humans confirm that this route of transplantation is associated with less probability of graft failure and moreover may reduce risk of graft-versus-host disease and malignancy relapse. for those purposes in the current study we investigate intrabone route of allogenic peripheral blood stem cell transplantation. our intention is to achieve fast engraftment and minimize risk of relapse and graft graft-versus-host disease.

Eligibility criteria:
inclusion criteria: * age 18-55 years * diagnosis of leukaemia or lymphoma * indication for allogenic stem cell transplantation according to european group for blood and marrow transplantation guidelines * hla-matched sibling donor qualified for peripheral blood stem cell donation * performance status who 0-1 * written informed consent exclusion criteria: * organ dysfunction: elevated alt, ast, bilirubin, af; creatinine \>1.5 upper normal limit; lvef \<45% * active infection * unstable diabetes * psychiatric diseases * obesity or anatomical obstacle for direct intrabone transplantation

Keywords: allogenic stem cell transplantation peripheral blood stem cells intrabone intra-bone leukemia lymphoma
safety and pharmacokinetic study of ati-50002 in subjects with alopecia universalis (au) and alopecia totalis (at)

Conditions: Alopecia Universalis (AU); Alopecia Totalis (AT)

Summary: the primary objective is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ati-50002 topical solution compared to vehicle in subjects with au and at.

this study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ati-50002 topical solution in patients with alopecia universalis and alopecia totalis. concentrations of ati-50002 in the blood and skin will be assessed after 28 days of treatment with ati-50002 topical solution.

Eligibility criteria:
inclusion criteria: * able to comprehend and willing to sign an informed consent form (icf). * male or non-pregnant, non-nursing female ≥18 years old at the time of informed consent. * have a clinical diagnosis of stable, clinically typical, au or at. * have a duration of the current episode of au or at for a minimum of 6 months and a maximum of seven years. * be willing and able to follow all study instructions and to attend all study visits. exclusion criteria: * females who are nursing, pregnant, or planning to become pregnant for the duration of the study including 30 days after the last application of study medication. * patchy alopecia areata, diffuse alopecia areata or a history of an atypical pattern of alopecia areata (aa) (e.g., ophiasis, sisaihpo). * active skin disease on the scalp (such as psoriasis or seborrheic dermatitis) or a history of skin disease on the scalp that in the opinion of the investigator would interfere with the study assessments of efficacy or safety. * active scalp trauma or other condition affecting the scalp that, in the investigator's opinion, may affect the course of au or at or interfere with the study conduct or evaluations. * the presence of a permanent or difficult to remove hairpiece or wig that will, in the opinion of the investigator, interfere with study assessments if not removed at each visit.
the feasibility of asthma application of mobile phone and mobile spirometry for home monitor of asthma patients

Conditions: Asthma

Summary: the aim of the present study is to explore if the "health lung" application of smart phone and portable spirometry "ezoxygen" can further improve asthma control for chronic asthma adult patients with well asthma control (act 20\~24, but not 25), compared to hospital-based usual care in a medical center.

asthma is a chronic inflammatory disease. despite we have academic treatment guidelines, and the asthma treatment develops persistently, many asthma patients do not have well control. asthma control test (act) is a patient self-administered tool for identifying those with poorly controlled asthma. act includes 5 items on 5-point scale, with 4-week recall on symptoms and daily functioning. the scores range from 5 (poor control of asthma) to 25 (complete control of asthma), with higher scores reflecting greater asthma control. an act score \>19 indicates well-controlled asthma. in addition to correct diagnosis and prescription by physicians, achieving asthma well control depend on the patient's ability of self- management. the self-management of asthma patients includes monitor of symptoms, monitor of peak expiratory flow, compliance of inhaler and avoiding the asthma triggers. portable digital tools may be the possible solution for home monitor of asthma patients. through the application of mobile phone and hand-held mobile spirometry, asthma patients can monitor their symptoms and lung function at home outside of hospital.(5-7)。 "health lung" (astrazeneca pharmaceuticals lp) is the application for mobile phone to help asthma care and is available freely in google play. health lung can be connected to the mobile spirometry, "ezoxygen" (genius holding co.,ltd taiwan branch). therefore, the functions of this app. include asthma control monitor, lung function monitor, controller and reliver inhaler reminder and recording, asthma educational topics in brief and information of air quality. the physicians can get the information about control status, lung function, adherence of controller and usage of reliver of patients between each clinical visit, if patients following the instruction of "health lung". however, how the patients are willing to use digital tools at home and what is the real impact on the current hospital-based asthma care need to be validated. the aim of the present study is to explore if the "health lung" application of smart phone and portable spirometry "ezoxygen" can further improve asthma control for chronic asthma adult patients with well asthma control (act 20\~24, but not 25), compared to hospital-based usual care in a medical center.

Eligibility criteria:
inclusion criteria: * patients aged 20 to 65 years old. * regular prescription of inhaled corticosteroid-containing medications at least 6 months. * the asthma control is well but not in total control: act 20\~24, but not to full score 25. exclusion criteria: * patients were excluded if they do not have internet-connecting smart phone.
evaluation of antimicrobial efficacy of green tea, garlic with lime, pomegranate extract and chlorhexidine mouth rinses in a group of egyptian children (in-vivo study)

Conditions: Dental Caries

Summary: the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.

the present study was carried out on 84 children. children were recruited based on certain inclusion criteria after signing a written informed consent by their parents. they were divided into 4 groups. group (i) the children rinsed with chlorhexidine mouth rinse, the child rinsed for 1 minute and plaque samples were collected from the child before and after rinsing. group (ii) children rinsed with green tea extract, while group (iii) children rinsed with garlic with lime extract and group (iv) the children rinsed with pomegranate extract mouth rinse with the same procedures. .child satisfaction was measured using 5-point pictorial likert scale which is graded from 1 to 5 (1.excellent.2.good.3 average 4.poor. 5. very poor). all the plaque samples were collected and put in sterile test tubes containing thioglycolate as a transport media. they transferred to the microbiology laboratory within half an hour after rinsing for detection of bacterial counts. these samples were incubated 48-96 hours at 37°c. number of bacterial colonies were counted by hand-held digital colony counter.

Eligibility criteria:
inclusion criteria:• age 5-8 years. * no history of systemic disease. * patients didn't received antibiotics for at least 3 months before and during the study exclusion criteria:• children who can't expectorate completely or brush their teeth on their own. * fixed or removable orthodontic appliances. * children with intra oral abscess, oral lesions or gingival diseases. * parental consent was not acquired

Keywords: herbal mouth rinses pomegranate caries prevention garlic extract green tea extract
noninvasive biomarkers for monitoring cardiometabolic risk in children

Conditions: Obesity; Metabolic Syndrome

Summary: the purpose of this study is to identify salivary biomarkers for monitoring cardiometabolic risk in children. the study hypothesis is that a combination of salivary biomarkers will predict the presence of risk factors including impaired fasting glucose, hypertension and dyslipidemia and will reflect changes in these risk factors over time.


Eligibility criteria:
inclusion criteria: * participating in the cardiac boot camp program * between the ages of 4 and 17 * parental permission * ability to provide assent exclusion criteria: * inability to comply with saliva collection procedures * renal insufficiency or juvenile gout
microvascular ocular changes of systemic lupus erythematous

Conditions: Eye Manifestations; Lupus Erythematosus, Systemic

Summary: the goal of this observational study is to to assess the ocular microvascular status of sle patients with inactive disease and without ocular involvement. the main questions it aims to answer are: * the choroidal vascular status and thickness in sle * the retinal macular microvascular status and structure in sle participants will be assessed with spectral domain optical coherence tomography (sd-oct). researchers will compare sle patients with healthy controls matched for age and sex.

the investigators will perform a cross-sectional evaluation of 25 sle patients and 25 healthy controls matched for sex and age, using a spectral domain optical coherence tomography (sd-oct) with enhanced depth imaging for choroidal assessment and with angiography module to assess the retinal and choriocapillaris vasculature. processing of image with external software will be performed to calculate the main outcomes: retinal vessel density, foveal avascular zone parameters and the choroidal vascular index.

Eligibility criteria:
systemic inclusion criteria for sle patients: * fulfill the 2019 european league against rheumatism (eular) / american college of rheumatology (acr) classification criteria for the diagnosis of sle * age between 18 and 80 years * no disease activity (sledai \<3) * no risk factors for drug toxicity systemic inclusion criteria for control group: * no systemic diseases * age between 18 and 80 years systemic exclusion criteria: * arterial hypertension (defined as systolic blood pressure higher than 140 mm hg or diastolic blood pressure higher than 90 mm hg) or medically treatment for hypertension * diabetes mellitus * nephropathy or other documented microvascular complications * secondary sjögren syndrome * local or systemic inflammatory diseases (other than sle) * smokers of more than 20 cigarettes a day * pregnancy. ophthalmological inclusion criteria: * best-corrected visual acuity ≤ 0.3 logmar * intra-ocular pressure \<21 mm hg on diurnal testing with measurements using goldmann applanation tonometry * spherical equivalent refractive error between -6.0 and +4.0 diopters * open anterior chamber angle on slit lamp examination. ophthalmic exclusion criteria: * established primary ocular diseases including a history of any retinal or optic nerve disease * presence of significant lens opacities (lens opacities classification system iii equal to or more stage 2) * retinopathy * high refractive error * ocular hypertension * previous intraocular surgery or trauma.
raising awareness of online therapies for depression: pilot study

Conditions: Depression

Summary: web based cognitive behavioural therapy (webcbt) for depression is recommended by nice but analysis of the geographic distribution of one webcbt site showed 15-fold variation in use across britain. such variation is unlikely to be from differences in prevalence. raising awareness of webcbt could benefit many people with depression but it is not clear how direct-to-patient promotion online or via the media, compares with gp centred methods. this pilot cluster randomised controlled trial will explore the use of online methods to raise awareness in preparation for subsequent study comparing different approaches. in a pilot cluster randomised trial the investigators will explore the feasibility and likely impact of online methods of raising awareness of webcbt, assessing how many people with depression respond to geographically restricted google and local website advertisements. the investigators will explore costs of recruitment and define and document the best online methods that might subsequently be used in a definitive trial comparing online with mass media and gp centred methods for raising awareness. the investigators will compare intervention with control areas to estimate impact on registration levels and compare rate of completion of webcbt of these 'additional' registrants with other registrants. recommendations will be made for a subsequent trial comparing online with other methods.


Eligibility criteria:
inclusion criteria: * people living in britain searching for online help for depression exclusion criteria:

Keywords: people living community
effect of intraoperative dexmedetomidine on postoperative delirium in elderly patients undergoing robot-assisted pancreaticoduodenectomy: a randomized controlled study

Conditions: Delirium in Old Age

Summary: to observe the effect of intraoperative dexmedetomidine on the incidence of postoperative delirium, postoperative analgesic drug requirements and pain scores in elderly patients undergoing robot-assisted pancreaticoduodenectomy.

this study is a multicenter, randomized, double-blind, placebo-controlled trial. three hundred patients undergoing elective robotic-assisted pancreaticoduodenectomy were randomized to the intervention and control groups. patients in the intervention group were given a loading dose of 0.6 μg/kg of dexmedetomidine by intravenous infusion within 10 minutes after intubation, followed by a continuous infusion at a rate of 0.4 μg/kg/h until 30 min before the end of the procedure; patients in the control group were given an equal volume of saline. data were collected at 1-5 days and 1 month postoperative follow-up.

Eligibility criteria:
inclusion criteria: * patients over 65 years old * patients undergoing elective robotic-assisted pancreaticoduodenectomy. * written informed consent was obtained. exclusion criteria: * patients with severe preoperative cognitive impairment (mmse ≤ 20) who are unable to undergo a follow-up evaluation. * patients with history of psychiatric or neurological disorders. * patients with body mass index ≤ 18 or ≥ 30 * pregnant or lactating women * patients with severe bradycardia (heart rate less than 40 beats per minute) * patients with pathological sinus node syndrome or grade 2 or greater av block * patients with severe hepatic or renal insufficiency. * patients with severe hypertension (systolic blood pressure ≥ 180 mmhg or diastolic blood pressure ≥ 110 mmhg)

Keywords: dexmedetomidine robot-assisted pancreaticoduodenectomy
effects of proprioceptive training in addition to routine physical therapy on balance and quality of life in patients with diabetic peripheral neuropathy

Conditions: Diabetic Neuropathy

Summary: objective of the study is to find out the effects of proprioceptive training in addition to routine physical therapy on balance and quality of life in patients with diabetic neuropathy. alternate hypothesis: there will be significant difference in effects of proprioceptive training in addition to routine physical therapy on balance and quality of life in patients with diabetic neuropathy.

it was a parallel designed single blinded randomized controlled trial conducted in the green poly clinic bahria town, lahore, pakistan using non probability convenient sampling. patients who met eligibility criteria was informed about the aim of study. consent form were signed by all participants.after baseline assessment ,participants were randomly assigned in two groups.(ratio 1:1) the calcualted sample size was 27 in each group. i.e. 54 ( 27 in each group). after adding 20% drop out the final size will become, 64( 32 in each group) using 95% level of significance and 80% power of study.

Eligibility criteria:
inclusion criteria: * patients with pre-diagnosed dm for seven years. * male and female patients with type 2 diabetes. * patients with ≥2 dpn symptoms. * patients scored\&gt;2/13 on mnsi questionnaire. exclusion criteria: * participants with foot ulcers, orthopedic or surgical problem in a lower limb, other neurological impairment and major vascular complication, * severe vestibular dysfunction * participants with severe retinopathy and severe nephropathy, * inability to walk independently with or without an assistive device, * receiving any structured supervised physiotherapy intervention.

Keywords: neuropathy proprioceptive training balance quality of life physical therapy