Kornimate/medical-research-clean huggingface dataset:
co monitoring for tobacco cessation in quitlines

Conditions: Tobacco Dependence

Summary: the present study is a 3-arm randomized controlled pilot study. participants who call the maryland tobacco quitline and are eligible for study participation are randomized to receive quitline tobacco cessation treatment as usual (tau), tau plus remote carbon monoxide (co) monitoring via smartphone app, or tau plus remote carbon monoxide monitoring plus incentives vis smartphone app. the investigators hypothesize that remote co monitoring will be feasible and acceptable to deliver in the quitline setting, will increase treatment engagement, and will increase tobacco cessation and treatment satisfaction rates.


Eligibility criteria:
inclusion criteria: * daily cigarette smokers calling into participating quitlines * 18 year or older * reads and speaks english * has a smartphone with a data plan * willing to download and use study app * willing to use co monitor exclusion criteria: • pregnant or breast feeding

Keywords: tobacco cessation tobacco quitlines carbon monoxide monitoring incentives
satisfaction of hospitalized diabetic patients using a continuous glucose monitoring system

Conditions: Insulin-Dependent Diabetes

Summary: the aim of the study is to establish whether routine usage of the freestyle libre™ system (abbott) improves satisfaction and quality of sleep in patients hospitalized for poor glycemic control with an indication for external insulin pump treatment.


Eligibility criteria:
inclusion criteria: * patient has given their free and informed consent * the patient must be insured or the beneficiary of an insurance policy * the patient is aged at least 18 years and less than 75 years old. * patients have a bmi between 18 and 40kg/m2 * diabetic patient admitted for glycemic instability with indication for treatment using an external insulin pump but otherwise in a stable clinical state exclusion criteria: * the subject is participating in another study * the subject is in an exclusion period determined by a previous study * the patients is under judicial protection or state guardianship * the subject refuses to sign the consent form * it proves impossible to give the subject clear information. * the patient is pregnant, parturient or breastfeeding * the patient is clinically unstable * bmi less than 18 or over 40 * existence of a severe rapidly progressive ischemic retinopathy or proliferative retinopathy. * serious psychiatric problems * chronic cutaneous infection
improvement of ards ventilation-perfusion matching by prone positioning assessed by eit

Conditions: Acute Respiratory Distress Syndrome; Prone Position; Electrical Impedance Tomography

Summary: acute respiratory distress syndrome (ards) is a highly lethal disease with limited treatment options. in recent years, prone position ventilation has been shown to improve the mortality rate and lung injury of ards patients by promoting lung recruitment, improving ventilation/perfusion (v/q) ratio, enhancing respiratory system compliance, promoting sputum drainage, and effectively avoiding overinflation of the dorsal lung. electrical impedance tomography (eit) technology has been used to evaluate the effect of prone position ventilation on lung v/q matching, and some studies have confirmed that prone position ventilation can improve lung v/q matching and oxygenation index. however, previous studies were mostly case reports or small-sample physiological studies that lacked dynamic changes in lung v/q matching during repeated prone position ventilation. therefore, this study hypothesizes that prone position ventilation can increase lung v/q matching in ards patients, and its improvement is correlated with changes in oxygenation index, invasive ventilation time, and patient prognosis. repeated prone position ventilation can maintain lung v/q matching at a higher level, no longer affected by changes in body position, which can accelerate pulmonary function recovery and improve the prognosis of ards patients.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old; 2. meet the diagnostic criteria of berlin's definition for ards; 3. invasive ventilation time \< 48h; 4. pao2/fio2 \< 150mmhg. exclusion criteria: 1. contraindication to the prone position; 2. contraindication to the eit; 3. hemodynamically unstable; 4. patients with hypernatremia; 5. patients have received extracorporeal membrane oxygenation treatment.
urdu version of kujala questionnaire: a reliability and validity study

Conditions: Patellofemoral Pain Syndrome; Anterior Knee Pain Syndrome

Summary: the aim of this research is to interpret and make kujala questionnaire adaptable culturally into urdu to investigate its validity and reliability in pakistani population among anterior knee pain or patello femoral knee pain. also check its correlation with 36-item short form health survey questionnaire, lysholm knee scoring scale and 2000 international knee documentation committee subjective knee evaluation form.

the original english version of kujala questionnaire will be translated and culturally adapted as per previous recommendation. in patients with anterior knee pain or patella femoral knee pain, kujala questionnaire-urdu will be distributed among hundred participants choose a convenience sampling technique based on pre-defined inclusion and exclusion criteria. to test reliability of inter/intra observer of ultimate final urdu version of kujala, 36-item short form health survey questionnaire, lysholm knee scoring scale and 2000 international knee documentation committee subjective knee evaluation form will be filled from patients on the equivalent day, by 2 different bystanders, and for inter observer valuation, with an interval of 30 minutes between the first and second application. third assessment will be carried out after 7 days of the observer -1 (re-testing), for intra-observer assessment. data will be entered and analyzed cronbach alpha value. test-retest reliability will be assessed using an intraclass correlation coefficient. urdu version of kujala was evaluated for content validity, construct validity, criterion validity and responsiveness.

Eligibility criteria:
inclusion criteria: 1. both genders 2. ages range from 18-40 years 3. they have clinically diagnosed with patello femoral pain syndrome (the diagnosis was established by a positive patellar grind test and pain on touch sensation, found in medial and lateral patellar facets) 4. participants who acquire 40 to 80 score on kujala patellofemoral questionnaire before the treatment start 5. patients willing to participate. exclusion criteria: 1. participants of the study who has gone through any treatment protocol curative measure for patellofemoral pain syndrome during the last 3 months. 2. any indication or medical record of lower extremity fracture or surgical procedure 3. history of certain chronic disease e.g. diabetes mellitus 4. participants unable to understand urdu version of kujala

Keywords: kujala questionnaire patello femoral pain syndrome anterior knee pain validity functional limitations reliability
prophylactic dimenhydrinate for intraoperative nausea and vomiting

Conditions: Nausea; Vomiting

Summary: the purpose of this study will be to determine whether an intravenous dose of dimenhydrinate (also known as gravol), given before the induction of spinal anesthesia, will decrease the incidence of intraoperative nausea and vomiting in patients undergoing cesarean delivery. this medication is commonly given during and after the surgery if required, but it is not known whether a preventative dose will decrease the overall incidence of these side effects.

nausea and vomiting remain one of the most common complications of cesarean delivery. the results of this study will show whether or not we can improve our present anesthesia regimen, and improve the satisfaction of patients undergoing cesarean deliveries, by reducing the incidence of nausea and vomiting. our current practice is not to use any medication for preventing nausea and vomiting unless required. however, nausea and vomiting come quite fast and unexpectedly during the operation, and most of the time the medication we give does not work fast enough. we are planning to study the anti-nausea medication dimenhydrinate (commonly known as gravol), which has been safely and widely used during pregnancy, labour and cesarean deliveries, hoping that its use will decrease the incidence of this unpleasant occurrence.

Eligibility criteria:
inclusion criteria: * all patients undergoing elective cesarean deliveries under spinal anesthesia. * all patients who gave written informed consent to participate in this study. * asa i and ii patients. * full term normal pregnancy. exclusion criteria: * all patients who refuse to give written informed consent. * all patients who claim allergy or hypersensitivity to dimenhydrinate. * patients with history of vomiting within 24 hours prior to cesarean delivery. * patients with history of gastrointestinal or psychiatric diseases and morbid obesity * patients receiving any of the following drugs within 24 hours before the study: opioids, antiemetics, h2 antagonists, phenothiazine and corticosteroids. * patients with severe pregnancy induced hypertension

Keywords: cesarean section dimenhydrinate gravol antiemetics
hiv diversity and pathogenesis in donor-recipient clusters

Conditions: Acquired Immunodeficiency Syndrome; Blood Transfusion; Blood Donors; HIV Infections

Summary: to assess, in donor-recipient clusters, current models of hiv-1 genetic evolution and pathogenesis, based on the sequence diversity displayed by this lentivirus.

design narrative: based on anti-hiv-1 screening of a repository of 200,000 blood donor sera collected in late 1984, the transfusion safety study identified and enrolled into ongoing followup 133 seropositive donors and 111 hiv-1-infected transfusion recipients. included among these were 38 'transmission clusters' composed of a donor and from one to six linked, infected recipient(s), and, in four cases, infected recipients' sexual partners. frozen cells and sera collected at six-month intervals over a six-year period from members of these clusters were available for study. specimens were accessed such that sub-repositories of cellular dna, pcr-amplified hiv-1 sequences, and viral isolates were generated for future investigations of these unique clusters. the studies included analysis of sequence diversity in envelope (env) v3, v4, and v5 hypervariable regions both within each infected individual over time, and between different members of each cluster and different clusters. sequence diversity profiles from pbmc and serum were analyzed separately to discern differences in these different blood components at each sampling and over time. the pattern of turnover of specific sequence variants over time (evolution of viral genotypes) was correlated with clinical and immunological progression. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
parental stress and attachment in preterm infants

Conditions: Premature Birth; Psychological Stress; Physiological Stress

Summary: introduction: advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. the possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. in fact, several studies have shown that the hospital environment of neonatal units may contribute to increased stress and anxiety in mothers. on the other hand, prematurity is one of the causes of referral to child development and early care centres, to address their development in the first years of life, as well as for family support. one of the functions of early childhood professionals is to guarantee the development of a secure attachment between the child and his or her caregivers. little is known about whether maternal stress levels can influence mother-child interactions and thus influence the attachment relationship in the early years of life. objective: to analyse the association between mothers' stress level due to preterm birth and attendance at a child development and early care centre and child development and patterns of mother-child interactions.


Eligibility criteria:
inclusion criteria: * children born under 37 weeks of gestation, * parents of legal age and who have sufficient cognitive capacity to understand the informed consent. exclusion criteria: -
a long-term, extended treatment study of aripiprazole in pediatric patients with autistic disorder

Conditions: Autistic Disorder

Summary: the objective of this study is to investigate the safety and efficacy of aripiprazole orally administered over long term in subjects who complete a short-term treatment study of pediatric autistic disorder (031-11-002 study).


Eligibility criteria:
inclusion criteria: * the patient meets autistic disorder diagnostic criteria defined in dsm-iv-tr. * the patient has completed the 031-11-002 study (the patient has visited the hospital during week8) * inpatient or outpatient status exclusion criteria: * the patient is currently diagnosed with another disorder on the autism spectrum in dsm-iv-tr, including asperger's, rett's disorder, pdd-nos, childhood disintegrative disorder, or fragile-x syndrome. * patients who fall under a contraindication listed in the abilify package insert * others

Keywords: autistic disorder, children and adolescents aripiprazole long-term safety study children and adolescents
preoperative pain catastrophizing and its association with postoperative pain after lower limb trauma surgery

Conditions: Pain, Postoperative

Summary: the pain catastrophizing scale (pcs) is a psychometric tool to identify pc. a positive correlation between pcs scores and various pain outcomes has been reported in acute and chronic pain settings. preoperative catastrophizing is associated with an increased intensity of postoperative pain and more analgesic consumption. likewise, a recent meta-analysis revealed that pc is a strong predictor of persistent postsurgical pain. the nepali version of pcs has been validated recently in patients with chronic pain. however, it has not been used in patients with acute pain. therefore, our aim is to assess the relationship between preoperative nepali pcs (n-pcs) scores and postoperative pain intensity and total opioid consumption in patients with musculoskeletal trauma planned for surgery.

after approval from institute review committee, we will assess eligibility of patients admitted in-patient-unit of orthopaedic ward planned for lower limb trauma surgery under spinal anesthesia. recruited patients will be counseled and informed about the study and information sheet and consent form provided. will obtain consent from the participant. patients will be asked to complete n- pcs questionnaire preoperatively a night before surgery in patient unit. on arrival to the operating room, standard monitoring will be applied. all the patients will receive spinal anaesthesia with 2.6 ml of hyperbaric bupivacaine (0.5%) and fentanyl 20 µg. nrs scale will be used to assess the intensity of their pain postoperatively on arrival to post-anesthesia care unit, at 2, 4, 6, 12 h and 24 h after the end of surgery. one gram paracetamol iv and ketorolac 30 mg iv will be given at the end of surgery and continued at 6 and 8 h intervals postoperatively. if the numeric rating scale (nrs) for pain is \> 3 at rest, tramadol 50 mg iv bolus administered, and repeated at 10 min intervals until nrs was ≤ 3 for the first 24 h. patients will be asked to rate their worst or maximum pain intensity during the first 24 hours after surgery, on an 11-point numerical rating scale. socio-demographic variables (age, bmi, ethnicity, gender, socio-economic status, occupation and education), preoperative anxiety of the participant will be recorded.

Eligibility criteria:
inclusion criteria: patients with traumatic lower-limb injury scheduled for lower-extremity surgery under spinal anaesthesia. american society of anaesthesiologists physical status i or ii, age between 18 and 65 years of age exclusion criteria: * non- responders, those unable to read and write; or patients with known psychiatric disorder, prior intake of pain medication, and chronic pain.
clinical investigation of the f-composite 2 system in direct filling therapy

Conditions: Dental Caries; Unsatisfactory or Defective Restoration of Tooth

Summary: the objective of this study is to evaluate the clinical performance of f-composite 2 system in class i and class ii cavities in permanent teeth. the materials of the system can be polymerized in short time with a curing light which is part of the system. the study will be carried out as a prospective study, with evaluation of the restorations after 7-10 days (baseline), at 6 months, at 12 months, at 24 months and 60 months according to defined criteria.


Eligibility criteria:
inclusion criteria: * indication for direct filling of class i or ii with permanent premolars or permanent molars * replacement of insufficient fillings (e.g., due to edge caries, filling fracture, lack of quality of the surface, lack of aesthetics, undesirable filling material, leaky edge, edge gap, etc.) * extensive primary caries * vital tooth (cold test) * one-, two- or three-surface fillings in the lateral tooth area, with a maximum of 25% single-faced (class i) with antagonists. * the occlusal area of the filling must be at least 1/3 of the total area of the filling tooth. this criterion is estimated. * patient wishes to receive care within the framework of the study (written consent after detailed elucidation and study of patient information). * maximum of 2 restorations per patient. * preoperative complaints on the tooth to be restored (maximum 3 on visual analog scale (0 = complaint-free, 10 = maximum possible pain) to temperature or bite sensitivity * sufficient language skills exclusion criteria: * unfinished hygiene phase or poor oral hygiene * sufficient draining of the operating field is not possible * patients with proven allergy to one of the ingredients of the materials used * patient has allergies to local anesthetic agents ultracain ds (active substance: articaine; vasoconstrictor), if anesthesia is desired * patients with severe systemic diseases * devital or pulpitic teeth * periodontal insufficiency * supplements with cusp attachments * open side bite * missing antagonist * indication for direct capping * pregnancy (women of childbearing age receive a free pregnancy test for self application, the negative result of which is shown with her confirmed consent).

Keywords: filling material, polymerization
effectiveness of viscum album mother tincture as an anti-hypertensive in essential hypertension

Conditions: Hypertension

Summary: to estimate the effectiveness of viscum album homoeopathic mother tincture in essential hypertension by conducting clinical trial in moderate hypertensive patients for a period of six weeks.


Eligibility criteria:
inclusion criteria: * hypertension at the range 180-120 mm of hg for systole \& * 110-80 mm of hg for diastole exclusion criteria: * patients who are on acei / arb for hypertension * diseases in which life expectancy is less than six months * secondary hypertension * chd * family history of mental illness like anxiety or depression. * nasal congestion

Keywords: essential hypertension viscum album mother tincture one group pretest post-test study
effect of a lacidofil® strong in healthy adults taking antibiotic treatment

Conditions: Antibiotic Associated Diarrhea

Summary: the objectives of this study are to evaluate stool consistency and stool frequency during and up to 8 weeks following a 7 day antibiotic treatment with amoxicillin/clavulanic acid 875mg bid.

it is hypothesized that the proportion of subjects having a diarrhea-like defecation, defined as a stool frequency ≥ 3 per day and/or stool consistency ≥ 5 (bristol stool score) for at least 2 days will be lower in the group receiving lacidofil® strong compared to the group receiving placebo and therefore mean bristol stool scores will be lower in subjects receiving lacidofil® strong compared to those receiving placebo.

Eligibility criteria:
inclusion criteria: * male or female aged 18 to 50 years inclusive * body mass index 18.0 - 29.9 kg/m2 * healthy as determined by laboratory results, medical history and physical exam * agrees to comply with study procedures * agrees not to change current dietary habits (with the exception of avoiding pro- and prebiotics) and activity/training levels during the course of the study * has given voluntary, written, informed consent to participate in the study exclusion criteria: * women who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial * body mass index ≥ 30 kg/m2 * average number of formed bowel movements \> 3 per day or \< 3 per week * participation in a clinical research trial within 30 days prior to randomization * use of antibiotics within 60 days prior to randomization. * habitual use of pro- and/or prebiotic products. subjects must not consume foods or supplements containing added pro- and/or prebiotics within 3 weeks prior to randomization and during the course of the study * use of laxatives, enemas or suppositories 1 week prior to randomization and for the duration of the study * follows a vegetarian or vegan diet * unstable medical conditions, as determined by the qualified investigator * history of chronic gastrointestinal disorders including irritable bowel syndrome; chronic constipation; chronic diarrhea; dyspepsia; gastroesophageal reflux disease; diverticulitis; colitis; crohn's disease; or any other malabsorption or gastrointestinal disorder * subjects with an immuno-compromised condition (e.g. aids, lymphoma, patients undergoing long-term corticosteroid treatment) * alcohol use \> 2 standard alcoholic drinks per day and/or alcohol or drug abuse within past year * allergy or sensitivity to test product ingredients or amoxicillin/clavulanic acid * individuals who are cognitively impaired and/or who are unable to give informed consent * any other condition which in the investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject