Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of trabecular meshwork microstent drainage system ( microcogo )

Conditions: Open-angle Glaucoma; Cataract

Summary: it is a prospective, multicenter, randomized, open label, parallel controlled, superiority clinical trial that evaluate efficacy and safety of trabecular meshwork microstent drainage system in reducing intraocular pressure in adult patients with mild to moderate open-angle glaucoma combined with cataract.

the trial is a prospective, multicenter, randomized, open label, parallel controlled, superiority study. eligible subjects will be randomly assigned to either test group or control group for treatment. the trial is divided into four research stages, with each subject expected to participate for maximum 14 months. the entire research phase includes: screening visit (v1, -60\~-1 day). baseline visit (v2). randomization and surgery (v3): the subjects will be randomly assigned in 2:1 ratio to either test group (phacoemulsification with implantation of iol combined with implantation of trabecular meshwork microstent drainage system) or control group (phacoemulsification with implantation of iol only). follow-up visits (v4 \~ v10): different time points after surgery.

Eligibility criteria:
inclusion criteria: * male of female, age 18 years or older * mild to moderate open-angle glaucoma * cataract * average of iop is less than or equal to 24mmhg with 1-3 drugs in the screening period * all 3 diurnal iops after drug-eluting are greater than 21mmhg and less than or equal to 35mmhg, average of diurnal iops is at least 3.0mmhg higher than the pre drug-eluting iop * cup to disc ratio (c/d) less than or equal to 0.8, or vfi greater than 75% * gonioscope shows that anterior chamber angle is open exclusion criteria: * traumatic, uveitic, neovascular, angle-closure glaucoma or glaucoma associated with vascular disorders * active corneal inflammation or edema * retinal disorders not associated with glaucoma

Keywords: cataract iop reduction open-angle glaucoma trabecular meshwork micro stent
determining of normal values and conformity assessment of the dosage of a plasmatic marker of the cellular captation of glucose: the irap protein

Conditions: Insulin Resistance

Summary: the purpose of this study is on one hand to verify the measurement conformity of the irap dosage and on the other hand to obtain normal values of the blood irap concentration on healthy volunteers.

this study consists of two visits, from two to five days apart. the first visit : * healthy volunteers will be on an empty stomach. * they will have a clinical examination, blood tests and blood samples will be taken to constitute a blood collection. the irap concentration will be measured with those samples. the second visit : this visit will take place in an interval from 2 to 5 days after the first visit. * subjects will be on an empty stomach * an oral glucose tolerance test (ogtt) of 3 hours will be performed. blood samples will be taken three time 15 minutes apart at baseline (before taking the glucose). and then after the glucose intake, blood sample will be taken every 15 minutes to measure insulinemia, blood glucose, and irap concentration.

Eligibility criteria:
inclusion criteria: * body mass index between 19 and 25 kg/m² * no intercurrent disease during the last week * no chronic infectious disease * no smoker, no alcoholic exclusion criteria: * history of : thyroid disease, liver or renal disease, endocrine and metabolic disease, cardiovascular disease, lung disease, gastroenterological disorders, psychiatric disease, epilepsy * consumption of narcotic drug * blood donation dating less than 2 months * pregnancy or breast-feeding, or intent to become pregnant during the study period * legal exclusion criteria

Keywords: irap insulin regulated amino peptidase diagnostic biomarker type 2 diabetes
neurotrainer cognitive training for academic focus

Conditions: ADHD - Combined Type; ADHD Predominantly Inattentive Type; ADHD, Predominantly Hyperactive - Impulsive

Summary: this clinical trial aims to evaluate the feasibility and efficacy of neurotrainer cognitive training in improving attentional and executive control functions in students with and without attention-related difficulties.

the goal of this clinical trial is to test the feasibility and efficacy of neurotrainer cognitive training in improving attentional and executive control function in students with and without attention-related difficulties. the main questions it aims to answer are (1) does neurotrainer improve attentional and executive control function, (2) does neurotrainer engage the target of adhd inattention symptoms by identifying the target and demonstrating proximal changes in it, and (3) does neurotrainer demonstrate transfer of skill with improvement in academic behaviors. researchers will compare students who use neurotrainer to a control condition to see if the neurotrainer intervention produces significant improvements. participants in the intervention group will engage in virtual reality (vr) sessions which include physical activity and cognitive training. cognitive training will maximize time at performance thresholds and optimize for variability in task dynamics and demands.

Eligibility criteria:
inclusion criteria: * diagnostic criteria met adhd for any adhd presentation type, with severity ratings of subthreshold, moderate or severe * estimated iq of 80 or greater * between 11-17 years of age exclusion criteria: * presence of suicidality * presence of psychotic disorders * visual or hearing impairment * presence of severe depression
comparison between interleukin 6 and procalcitonin in detecting sepsis and incidence of mortality in burn icu patients

Conditions: Burns; Sepsis; Septic Shock; Death

Summary: the investigators will compare the efficacy of interleukin-6 (il-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early icu discharge.

interleukin 6 and procalcitonin will be sampled for all patients on days 1, 3, 7, and 10. treatment plan will be initiated to all patients according to the burn icu protocol. according to the lab results, interleukin 6 and procalcitonin will guide the investigators to take decisions regarding clinical improvement and icu stay.

Eligibility criteria:
inclusion criteria: * patients with acute burn admitted to burn icu within 24 hours from the burn incidence. * patients with burn percentage of 25% to 50% of total body surface area * patients with second to third degree burns * asa 1 and asa 2 patients exclusion criteria: * burn percentage more than 50% or less than 25% of total body surface area * having autoimmune diseases * cancer patients * asa 3 and asa 4 patients
rectal indomethacin vs intravenous ketorolac

Conditions: Post-ERCP Acute Pancreatitis

Summary: endoscopic retrograde cholangiopancreatography (ercp) is an essential procedure that can be complicated by post-ercp pancreatitis (pep). indomethacin and ketorolac are two medications used to prevent pep. the main reason for this research study is to compare the effectiveness these drugs at reducing rates of pep. there have been no studies comparing the effectiveness of these medications in preventing pep in pediatric patients. you are being asked to take part in this research study because you are scheduled to have an ercp as part of your medical care.


Eligibility criteria:
inclusion criteria: * any patient undergoing ercp (diagnostic or therapeutic with cannulation of the major or minor papilla) * age 6 month- 21 years old * does not meet exclusion criteria exclusion criteria: * \< 10 kg * low risk subgroup: biliary indication with history of prior biliary sphincterotomy. * high risk for bleeding (example: planned liver biopsy) * gastrointestinal bleeding in previous 3 days * acute pancreatitis (within 3 days) at the time of ercp * use of nsaids in the previous 5 days * peptic ulcer disease * acute kidney injury or known chronic kidney disease per kdigo * pregnancy (pregnancy tests are administered prior to ercp as standard of care) * lithium therapy * allergy to ketorolac or indomethacin * organ dysfunction or sirs
comparison between chf5993 pmdi 200/6/12.5 µg hfa-152a vs chf5993 pmdi 200/6/12.5 µg hfa-134a in subjects with asthma (trecos).

Conditions: Asthma

Summary: the cli-05993ab6-03 study is an interventional study designed to investigate the safety and efficacy of a new low global warming potential propellant (hfa-152a) compared to the currently approved one (hfa-134a) in the medication (chf5993) in patients with moderate to severe asthma

outpatients attending the hospital clinics/study centers will be recruited. moderate to severe controlled asthma adult subjects will be recruited. a total of 513 subjects will be randomised. the whole study will last approximately 16 weeks for each subject.

Eligibility criteria:
inclusion criteria: * subject's written informed consent obtained prior to any study related procedure; * male and female adults aged ≥ 18 and ≤ 75; * body mass index (bmi) within the range of 18.0 to 35.0 kg/m2 inclusive; * non-smokers or ex-smokers who smoked \ 1 year (6 months for e-cigarettes) prior to screening; * diagnosis of asthma: physician-diagnosed asthma for at least * 6 months and with diagnosis before the age of 50 years; * stable asthma therapy: a stable treatment with medium/high doses of inhaled corticosteroids (ics) + long-acting β-agonist (laba) + long-acting muscarinic antagonist (lama) (fixed or free combination) or medium/high doses of ics+laba (fixed or free combination) for at least 4 weeks before screening (medium and high-dose ics defined as bdp non-extrafine \> 500-1000 μg and \> 1000 μg respectively, or estimated clinical comparable dose). * subjects must have a cooperative attitude and the ability to be trained to use correctly the pmdi inhalers and e-diary, to be able to read/write, to be able to perform the required outcomes measurements (e.g., technically acceptable spirometry, e-diary completion) and the ability to understand the risks involved. exclusion criteria: * history of near fatal asthma, hospitalisation for asthma in intensive care unit which in the judgement of the investigator may place the subject at undue risk, emergency room access for asthma in the previous 6 months before enrolment; * asthma exacerbation requiring systemic corticosteroids (scs) or emergency room admission or hospitalisation within 4 weeks prior to study entry and/or during the run-in period (to be checked again prior to randomisation); * non-permanent asthma: exercise-induced, seasonal asthma (as the only asthma-related diagnosis) not requiring daily asthma control medecine
cardiovascular evaluation before renal transplantation

Conditions: Chronic Kidney Disease; Coronary Artery Disease

Summary: due to rising importance of cardiovascular disease before and after renal transplantation we have changed our standard diagnostic procedure and perform stress echocardiography and myocardial scintigraphy. we would like to monitor these results and the outcome of our patients.

chronic kidney disease is a well-known risk factor for cardiovascular disease. patients waiting for a renal transplantation usually undergo an extensive diagnostic procedure to avoid complications after transplantation such as neoplasia or inflammation. in the past years, cardiovascular complications before and after renal transplantation have gained more attention. we therefore have changed our standard diagnostic procedure before renal transplantation and perform stress echocardiography and myocardial scintigraphy. thus we would like to evaluate our new standard diagnostic procedure and observe the results of these diagnostic procedures as well as their impact on clinical outcome.

Eligibility criteria:
inclusion criteria: * endstage renal disease * preparing for renal transplantation exclusion criteria: * children (\< 18 years) * women who are pregnant or nursing * patients who are also awaiting heart transplantation or have already a heart transplant * severe mental illness

Keywords: renal transplantation cardiovascular morbidity evaluation before renal transplantation
does the presence of cervical facet tropism affect the response to interlaminar epidural steroid injections?

Conditions: Cervical Disc Herniation; Cervical Radicular Pain; Facet Tropism

Summary: facet joints are synovial joints located on the dorsolateral side of the vertebral column. normally, both facet joints are symmetrical. facet tropism (ft) is defined as asymmetry between the angles of orientation of the joints, in which a facet joint in the same segment is more sagittally oriented than the other. in 1967, farfan and sullivan first reported that ft is a possible risk factor for the development of disk herniation. however, this is controversial as there are other views advocating that ft is not a risk factor for the development of cervical disc herniation. further, it has been emphasized that patients with ft have a greater need for adjacent segment degeneration and new spinal surgery after spinal fusion surgeries than those without ft. in the current literature, studies have been conducted to examine the clinical and radiological parameters that may be related to the effectiveness of cervical interlaminar epidural steroid injections (ilesi). the aim of this study was to examine the effect of the presence of ft on ilesi results in patients with cervical disc herniation-induced radicular pain.


Eligibility criteria:
inclusion criteria: aged 18-75 years, who applied to the pain medicine outpatient clinic, had axial neck and unilateral radicular extremity pain for at least 3 months, and were diagnosed with protruded disc herniation by magnetic resonance imaging were included in the study exclusion criteria: patients with systemic inflammatory disease, bleeding diathesis,history of psychiatric illness, malignancy, contrast material or local anesthetic agent allergy, cervical spinal stenosis, history of cervical esi, or neck surgery in the last 3 months were excluded from the study

Keywords: facet tropism cervical disc herniation cervical radicular pain
to evaluate the safety and performance of the prostacare water electrolysis system in relieving symptoms of bph.

Conditions: Benign Prostatic Hyperplasia

Summary: the purpose of this study is to evaluate the safety and performance of the prostacare system in relieving symptoms of urinary outflow obstruction secondary to benign prostatic hyperplasia.


Eligibility criteria:
key inclusion criteria: * 45 years of age or older with a diagnosis of bph, * international prostate symptom score (ipss) of 12 or greater, * prostate volume between 25 cm3 and 55 cm3, * uroflow with peak flow rate (qmax) no greater than 13 ml/sec with a corresponding voided volume of at least 100 ml and a post void residual (pvr) of 250 ml or less. * prostate length, width and height must be at least 3.2 cm, 3.5 cm and 2.5 cm, respectively key exclusion criteria: * obstruction due to an enlarged middle lobe, central gland or significant transverse asymmetry, * subjects on 5 alpha reductase inhibitors (5-ari) (inclusion only if washed out prior to treatment), * subjects on alpha blockers (inclusion only if washed-out before treatment), * active urinary tract infection at time of treatment, * interest in maintaining fertility, * past history of urologic surgery or minimally invasive treatment for bph, * history of or current medical conditions contraindicating elective urological procedures.

Keywords: bph
cell-based non-invasive prenatal testing as an alternative to invasive chorionic villus sampling

Conditions: Hereditary Diseases

Summary: the study aims to evaluate cell-based non-invasive prenatal testing (cbnipt) as an alternative to invasive chorionic villus sampling (cvs) in patients who achieve pregnancy following preimplantation genetic testing for hereditary disorders.

the study has three main objects: 1. to evaluate the optimal time of blood sampling (gestational week 7-8 or 11-14) 2. to evaluate whole genome amplification prior to genetic analysis og isolated fetal cells (only relevant for monogenic disorders) 3. evaluating specificity and sensitivity

Eligibility criteria:
inclusion criteria: * pregnancy following preimplantation genetic testing exclusion criteria: * none

Keywords: cell-based non-invasive prenatal testing hereditary disorders
tms in borderline personality disorder patients

Conditions: Borderline Personality Disorder

Summary: the purpose of this study is to determine the potential effects of repetitive transcranial magnetic stimulation in the improvement of neuropsychological deficits and symptomatology in borderline personality disorder patients. specially in cognitive flexibility, inhibition control and social cognition.

this is a randomized, parallel group clinical trial to evaluate the efficacy of two protocols of repetitive transcranial magnetic stimulation (rtms), the application will be over dorsolateral prefrontal cortex (dlpfc) right and left, in patients with borderline personality disorder. 40 ambulatory patients with a borderline personality disorder diagnosis from the national institute of psychiatry in méxico will be included. all patients will be randomly assigned and will complete a total of 23 sessions rtms, in any of two groups: 5 hz group.- this group will receive rtms sessions, 5 per week during three weeks (acute treatment phase), and after that, one session a week for the next eight weeks (follow up). the rtms will be applied over the left dlpfc at 5 hz, 1500 pulses per session in 100% of motor threshold 1 hz group.- this group will receive rtms sessions, 5 per week during three weeks (acute treatment phase), and after that, one session a week for the next eight weeks (follow up). the rtms will be applied over the right dlpfc at 1 hz, 900 pulses per session in 100% of motor threshold all sessions will be applied with a "dantec" transcranial magnetic stimulator. the affective, borderline and anxiety symptoms will be evaluated at baseline, and every 5 tms sessions during the acute treatment phase, and once at the end of the 8-weeks follow up. in same form for neuropsychological evaluations . categorical variables will be described by percentages and frequencies. continuous variables will be described by means and standard deviations. treatment groups will be compared using student's t test. cognitive, anxiety, borderline and affective symptom scale scores between treatment groups will be compared using repeated measures anova

Eligibility criteria:
inclusion criteria: * diagnosis of borderline personality disorder according to diagnostic and statistical manual of mental disorders iv text revision * treatment with selective inhibitors of serotonin reuptake * mass corporal index more than 19 exclusion criteria: * suicide risk or suicide attempt recent or actual * history of epilepsy or seizures * history of cranial trauma with loss awareness * intracranial or intraocular ferromagnetic devices, including skull prosthesis. * pregnant womens. * neurosurgery, cardiac pacemaker, lefthander * patients with psychotic symptoms, bipolar disorder or substance addiction.

Keywords: borderline personality disorder transcranial magnetic stimulation, repetitive
efficiency of intercoat (oxiplex/ap gel) in preventing intrauterine adhesion formation in hysteroscopic surgery

Conditions: Asherman Syndrome; Endometrial Polyp; Uterine Myoma

Summary: the study purpose is to examine the influence of intercoat in prevention of intra-uterine adhesions formation after any hysteroscopic surgery.


Eligibility criteria:
inclusion criteria: * age between 18 and 50 years * must be able to understand, read and sign consent form exclusion criteria: * signs of infection upon admission * ongoing pregnancy * carcinoma of the uterus or cervix * recurrent pid * women admitted for endometrial ablation * women that gave birth 6 weeks ago * women participating in another study
effectiveness comparison of thoracic thrust manipulation in people with neck or low back pain

Conditions: Neck Pain; Low Back Pain

Summary: objective: to compare the effectiveness of thoracic thrust manipulation, together with massages techniques and stretching, between people with neck pain versus people with low back pain. methods: the research will be performed from august 2021 to october 2021 at the university of alcala de henares. (madrid) a minimum of forty-six (46) volunteers will participate in this research, and they will be divided in two groups of twenty-three (23). one group will be formed by candidates suffering from neck pain (group a) and the other one by candidate with low back pain (group b). both groups will receive the same treatment and specific stretching exercises as applicable in accordance to the pain area, e.g.: group a will get the massage and the stretching exercises more suitable for the neck pain and group b the same but for the low back pain. nevertheless both groups will receive the same technical thrust manipulation in thoracic area. all these treatments will be applied of the volunteers at the university of alcalá. the treatment includes the following activities: 1. twenty (20) minutes massage in the pain area, as applicable. 2. technical thrust manipulation in thoracic area. 3. ten (10) minutes stretching in accordance to the pain area treated. the stretching shall be repeated twice a week by each volunteer. a total of six (6) sessions will be carried out during six (6) weeks, one session per week. pain, disability, kinesiophobia, hrqol will be assessed as follow: 1. before first session. (in this evaluation will be also analyzed demographic variables i.e.: height, weight, age, gender, academic level, smoker/no smoker) 2. between third and fourth session. 3. after sixth session. 4. four weeks after sixth session.


Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * non-specific neck/low back pain for the last three (3) months before the first session. exclusion criteria: * previous surgery in the areas covered by this research (neck and/or low back) * red flags: cancer or tumor, fracture... * scoliosis or osteoporosis * neck or low back pain with radiculopathy symptoms * central nervous system involvement * fear to manipulation * neck pain associated with whiplash injuries on the last six (6) months * pregnant women * not understand, write and speak spanish fluently

Keywords: neck pain low back pain spinal manipulation acute pain