Kornimate/medical-research-clean huggingface dataset:
conventional photodynamic therapy vs. painless photodynamic therapy for moderate or severe acne

Conditions: Acne

Summary: this study is being done to compare a new, continuous illumination and short incubation time regimen of aminolevulinic acid photodynamic therapy#ala- pdt) to a conventional regimen for treatment of moderate or severe acne. the hypothesis is that the continuous illumination approach will be less or even no painful, but equally efficacious, as the old regimen.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosed with moderate to severe acne; 2. male and female patients of age between 18-30 years old ; 3. all patients read the instructions of the subject, willing to follow the program requirements; 4. no other topical treatment received within 2 weeks prior to enrollment; 5. no systemic treatment was given within 4 weeks prior to enrollment; 6. patients were unsuitable for surgery for various reasons,unwilling to undergo surgery, and signed informed consent when they had informed other alternatives and agreed to take pictures of the lesion. - exclusion criteria: 1. those who did not complete the informed consent; 2. the lesions belongs to any of the following conditions: there is damage and inflammation, which may lead to the drug entering the open wound; 3. patients with skin photoallergic diseases, porphyria; 4. known to have a history of allergies to test drugs (porphyrins) and their chemically similar drugs; 5. patients with other obvious diseases that may affect the evaluation of efficacy; 6. scars or patients with a tendency to form scars; 7. known to have severe immune dysfunction, or long-term use of glucocorticoids and immunosuppressants; 8. severe heart, liver, kidney disease; with hereditary or acquired people with sexual coagulopathy; 9. those with severe neurological, psychiatric or endocrine diseases; (10)women who are pregnant, breast-feeding or using inappropriate contraceptives; those with a history of drug abuse; those who have participated in other drug clinical trials within 4 weeks before treatment.

Keywords: photodynamic therapy conventional painless acne
breaking bad news skills of doctors and residents in the surgical setting

Conditions: Communication Research; Patient Satisfaction; Communication Programs; Doctor Patient Relation

Summary: breaking bad news is a very stressful and difficult situation for health care professionals, especially clinical doctors and surgeons. acquiring skills for this sort of communication is very important due to the large volume of times that these professionals will have to deal with it and because it can affect the doctor-patient relationship forever. the objective of this study is to evaluate the skill of surgeons and residents in surgical specialties in breaking bad news to patients and families across spanish hospitals. this will be done by analyzing the subjects in terms of their knowledge and experience using a specialized questionnaire based on breaking bad news protocol, designed in the "hospital sant joan de déu" children's hospital in barcelona.


Eligibility criteria:
inclusion criteria: - doctors working in the surgical setting that accept and answer the specialized questionnaire. exclusion criteria: * questionnaire answered out of the time-frame * incomplete questionnaires

Keywords: breaking bad news communication skills surveys and questionnaires health knowledge, attitudes, practice anesthesiology specialties, surgical
efficacy and clinical outcomes of levosimendan in e-cpr

Conditions: Cardiogenic Shock; Extracorporeal Membrane Oxygenation Complication

Summary: treatment of refractory cardiac arrest requiring cardiopulmonary resuscitation (cpr) may be augmented with extracorporeal membrane oxygenation (ecmo) to re-establish perfusion in the absence of return of spontaneous circulation. literature has demonstrated that ecmo initiated during advanced cardiopulmonary life support may confer superior survival rates with acceptable survival and a relatively low incidence of significant neurologic impairment. levosimendan has not been investigated in patients with cardiac arrest who underwent extracorporeal cpr (e-cpr). the current study aims to examine whether levosimendan use in the aforementioned patient population could improve survival and ecmo parameters.


Eligibility criteria:
iinclusion criteria: * hospitalized patients ≥ 18 years of age at the time of e-cpr use * patients suffered cardiac arrest (ihca or ohca) * patients received va-ecmo for e-cpr * criteria as per hmc's extracorporeal membrane oxygenation (ecmo) for cardiac arrest (e-cpr) clinical practice guidelines (attached with the study protocol) exclusion criteria: * patients with incomplete key data * criteria as per hmc's extracorporeal membrane oxygenation (ecmo) for cardiac arrest (e-cpr) clinical practice guidelines (attached with the study protocol)

Keywords: levosimendan ecpr neurological outcome
study of stimulus parameters in flicker electroretinogram (erg)

Conditions: Retinopathy

Summary: the electroretinogram (erg) is a diagnostic test that measures the electrical activity generated by cells in the retina in response to a light stimulus. typically, an erg is recorded with white flash when the pupil is dilated. reteval visual diagnostic device (reteval) generates an array of color flashes, which allows studying whether color flash would be a useful diagnostic tool. full pupil dilation is required to obtain a response from the whole retina. however, this requirement often limits a patient's flow in the clinic and increases the overall time patients spend at the eye practitioner. reteval provides the possibility of recording ergs in un-dilated pupils therefore making the whole exam easier and shorter. these results need to be compared to the classic, fully dilated erg and evaluated for efficiency. the purpose of this research study is to use the reteval device to measure the eye's electrical response and how it changes with different stimuli such as changing flash color or pupil dilation.


Eligibility criteria:
inclusion criteria: * healthy adult volunteers * volunteers able to get their pupil fully dilated exclusion criteria: * pregnant women * children * subjects with * light sensitivity * photosensitive epilepsy * allergies or sensitivity to pupil dilation ophthalmic solutions * history of glaucoma * cardiac dysrhythmia will not be invited to participate in this study. * pregnancy status, light sensitivity and photosensitive epilepsy will be based on volunteer's providing this information at the time of signing the consent form

Keywords: retinal function
guiding dose increases in patients incompletely responsive to usual doses of atomoxetine

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this trial is to test the value of dose increases in patients with residual adhd symptoms after treatment with the usual target dose of atomoxetine


Eligibility criteria:
inclusion criteria: * outpatients who are at least 6 years of age and not more than 16 years of age at visit 1 * patients must meet dsm-iv diagnostic criteria for adhd (any subtype) * patients must have laboratory results showing no significant abnormalities (significant would include laboratory deviations requiring acute medical intervention or further medical evaluation) * patients must be of normal intelligence as assessed by the investigator (that is, without a general impairment of intelligence and likely, in the investigator's judgment, to achieve a score of greater than or equal to 70 on an iq test) * patients must be able to swallow capsules exclusion criteria: * patients who weigh less than 25 kg or greater than 70 kg at study entry * patients with current or past bipolar i or ii disorder, psychosis, autism, asperger's syndrome, or pervasive developmental disorder * patients with a history of any seizure disorder (other than febrile seizures) or patients who have taken (or are currently taking) anticonvulsants for seizure control * patients with a history of severe allergies to more than 1 class of medications or multiple adverse drug reactions * patients with cardiovascular disease or other conditions that could be aggravated by an increased heart rate or increased blood pressure
opioid sparing anesthesia in lumbar spine surgery

Conditions: Pain, Postoperative; Pain, Acute; Pain, Chronic; Pain, Nociceptive; Ketamine; Lidocaine; Dexmedetomidine; Analgesia; Analgesics; Lumbar Spine Surgery

Summary: the aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar spine surgery

lumbar spine surgery is associated with high pain scores and perioperative disability. ketamine, lidocaine and dexmedetomidine have all proven but varied analgesic effects. high opioid consumption has been associated with multiple side effects. this double blind clinical trial aims to investigate the possible reduction of opioid use during lumbar spine surgery by administering ketamine, lidocaine and dexmedetomidine. sixty patients will be randomly allocated into two groups. the control group will receive a continuous infusion of remifentanil, while the dexmedetomidine-ketamine-lidocaine (dkl) group will receive a continuous infusion of ketamine, lidocaine and dexmedetomidine, during the surgery and shortly after both infusions will be administered blindly. fentanyl and morphine will be administered to each patient so as to maintain hemodynamic stability and pain relief. the study will eventually compare the need for bolus doses of fentanyl during the surgery and morphine shortly after in each group. multiple hemodynamic parameters, analgesic consumption, possible side effects, patient satisfaction and the oswestry low back pain disability questionnaire will be recorded.

Eligibility criteria:
inclusion criteria: * adult patents * american society of anesthesiologists (asa) class i-iii * elective spine surgery exclusion criteria: * body mass index (bmi) \>35 kg/m2 * contraindications to local anesthetic administration * systematic use of analgesic agents preoperatively * chronic pain syndromes preoperatively * neurological or psychiatric disease on treatment * pregnancy * severe hepatic or renal disease * history of cardiovascular diseases/ arrhythmias/ conduction abnormalities * bradycardia(\<55 beats/minute) * drug or alcohol abuse * language or communication barriers lack of informed consent
women's satisfaction and adherence to vulvovaginal atrophy treatments

Conditions: Vulvovaginal Atrophy

Summary: the primary objective of this study is to describe and assess participants' satisfaction with current vulvovaginal atrophy (vva) treatment.

this study is designed as a multicenter, cross-sectional, descriptive, observational study.

Eligibility criteria:
inclusion criteria: * women with natural menopause established for at least one year. * absence of menstruation for at least one year. * mild, moderate or severe vva diagnosis. * currently under treatment with either ospemifene, local oestrogen therapy or moisturizers for at least 3 months in accordance with the approved smpc and/or patient leaflet * patients providing writing informed consent for participating in the study. exclusion criteria: * women who have never been previously treated for vva * women who have discontinued their vva treatment due to a contraindication in the study group drug. * patients using more than one vva treatment at a time (except for lubricants). * breastfeeding, pregnancy or under any kind of systemic hormonal treatment that causes amenorrhea. * local phytotherapy for vva.
trans care: an online intervention to reduce symptoms of gender dysphoria

Conditions: Gender Dysphoria

Summary: the current project aims to improve the well-being of trans and nonbinary (tnb) individuals through an online intervention (trans care) targeting the reduction of symptoms of gender dysphoria. the trans care intervention will involve the creation of an online intervention comprised of eight modules intended to reduce symptoms of gender dysphoria, increase active coping, and improve the well-being of tnb individuals. aim 1 is a feasibility and acceptability study of the proposed intervention and will enroll 100 tnb participants to provide feedback to inform a follow-up randomized controlled trial.

the overall purpose of this project is to create a free intervention that can be disseminated widely throughout tnb communities to improve well-being in an easy, accessible way. development and execution of the trans care intervention involves two primary aims: * aim 1) feasibility and acceptability analysis (faa) \[represented by this study record\] * aim 2) a pilot randomized controlled trial (rct) of trans care's efficacy \[to be registered to a separate study record\] aim 1 involves qualitative and quantitative feedback regarding the content of the trans care intervention modules, impact on tnb participants well-being, and feasibility and acceptability of trans care intervention. results from the faa study will then be analyzed and presented to our community partners who will help us develop modifications to trans care to increase its efficacy and ease of use. aim 1 hypotheses: * the investigators expect that qualitative responses from participants in the faa study overall will reflect that the trans care intervention was feasible and helpful. any proposed changes from participants' qualitative responses will be incorporated into the final trans care intervention presented in the rct. * the investigators expect that participants in the faa study will endorse high scores three scale assessment of feasibility and acceptability. aim 1 endpoints: the primary endpoint of the study is to determine if the trans care intervention is feasible and helpful to tnb individuals for improving their coping strategies. this will be determined through qualitative prompts and a quantitative measure of feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * identify as transgender, transsexual, nonbinary, and/or have a transgender history. * experience gender dysphoria. * time available to commit to completing a 4-5-hour online intervention and 1-2 hours to complete follow up surveys exclusion criteria: * under 18 years old * individual does not identify as transgender, transsexual, nonbinary, and/or have a transgender history * does not experience gender dysphoria * is unable to commit to the time requirements of the study * does not have access to an internet compatible device

Keywords: coping trans and nonbinary online intervention gender minority stress
first in human trial of tas266 in patients with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: this study will assess safety, tolerability, maximum tolerated dose or recommended dose for expansion of tas266 administered by iv infusion to patients with advanced solid tumors.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of solid tumors * 18 years or older * ecog performance status of 0, 1 or 2 * adequate bone marrow, hepatic and renal function * obtained written informed consent exclusion criteria: * patients with primary cns tumor or cns tumor involvement. however patients with cns metastases may be allowed if certain conditions are met. * major surgery within 4 weeks before study treatment * prior anaphylactic or other severe infusion reactions to human immunoglobulin or antibody formulations * impaired cardiac functions * previous hepatitis viral infection such as hepatitis b or hepatitis c * diagnosis of hiv infection * pregnant or nursing (lactating) women other protocol-defined inclusion/exclusion criteria may apply

Keywords: biologic, solid tumors, death receptor 5 agonist, caspase-8
circulatory oscillations in post cardiac surgery patients

Conditions: Coronary Disease

Summary: in this observational study investigators examine the presence of circulatory oscillations in blood pressure, heart rate, and doppler laser flow before and after planned cardiac surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled for routine coronary artery bypass graft (cabg) surgery, single procedure only exclusion criteria: * no sinus or pacemaker rhythm * ejection fraction below 0.5 * serious valvular disease * right ventricular failure * pulmonary hypertension * serious postoperative bleeding

Keywords: blood circulation cardiac surgical procedures homeostasis
eliminating hcv in rural south carolina utilizing np led mobile clinics and virtual care coordination

Conditions: Hepatitis C; Substance Use Disorders

Summary: up to 150 individuals with current hepatitis c (hcv) will be recruited from mobile health clinics in rural south carolina - sites will be selected based on hcv prevalence rates and lack of current hcv screening/treatment resources. nps will provide hcv care through mobile health units. participants will be randomized (1:1) to either mobile health clinic treatment as usual or virtual care coordination. virtual care coordination designed to move people along hcv care cascade will be conducted by the emocha smartphone platform - an adaptable platform designed by emocha to link patients to care. using quantitative methods, associations between psychosocial factors such as homelessness, mental illness, provider mistrust, poor social support, high levels of shame and stigma with hcv outcomes including svr will be examined. investigators hypothesize that svr rate among the hcv-infected individuals treated (and with follow-up svr determination) will be 90% with the clopper-pearson 95% ci having a width of 13%.


Eligibility criteria:
inclusion criteria: * not previously treated with hcv direct-acting antiviral medications or treatment-experienced and eligible for treatment with sofosbuvir/velpatasvir * age 18+ * willing to be randomized to either emocha versus tau arms * able to provide informed consent exclusion criteria: * pregnant or breastfeeding

Keywords: mobile health nurse practitioner care coordination virtual care coordination people who inject drugs rural health
visual function in pediatric patients with posterior lens opacities

Conditions: Congenital Cataract Polar Posterior

Summary: prognostic factors determining visual outcomes in patients with posterior polar cataracts and posterior lenticonus are largely unknown. in this trial, the investigators aimed to evaluate the visual outcomes in patients with posterior polar cataracts and posterior lenticonus and try to find out the factors associated with the visual acuity after surgery. patients enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.

congenital cataract patients have a wide range of presentations of lens opacities with different impact on visual function. polar cataracts are opacities of the subcapsular cortex in the polar regions of the lens. to our knowledge, anterior polar cataracts are usually visually insignificant, however, even a small posterior lens opacity can impair vision because of their close proximity to the macula. visual impairment could be caused by an opacity that blocks the visual axis, refractive error, posterior lesion-induced optical distortion, or amblyopia. therefore, surgery is often recommended when visual function is significantly affected. the primary indication for surgical intervention in cataract is poor visual acuity. however, the previous studies have shown that preoperative visual acuity is a poor predictor of improvement in the subjectively experienced quality of vision after cataract surgery. considering the increased risk for capsule rupture during surgery and the sacrifice of accommodation after cataract surgery in eyes with posterior lens opacities, the decision of surgical intervention must be carefully weighed. in this trial, the investigators aimed to evaluate the changes of visual function, including visual acuity, modulation transfer function, ocular aberrations in the participants with posterior lens opacities. moreover, various factors which might be associated with postoperative visual acuity were explored. the participants enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.

Eligibility criteria:
inclusion criteria: * children with posterior polar cataracts or posterior lenticonus who need cataract surgery * aged 3-14 years * have signed a consent form * can be followed exclusion criteria: * have relevant ocular disease other than congenital cataract * could not cooperate to the examinations

Keywords: visual function posterior polar cataracts posterior lenticonus
a pilot evaluation of the impact of alcohol use on airway inflammation and mechanics in asthmatics

Conditions: Asthma

Summary: since 1980, the number of people in the united states diagnosed with asthma has increased dramatically. studying what causes and triggers asthma is an important part of understanding and subsequently managing this disease. although some have suggested that alcohol consumption may affect asthma, little is known about how consistent alcohol use affects the amount of inflammation present in the lungs and whether consistent alcohol use makes the airways more narrow and stiff. participation in this study involves 2 visits in order to complete questionnaires, various pulmonary function tests, as well as the collection of blood, urine, and exhaled breath condensate specimens. this study includes optional genetic and bronchoscopy substudies.


Eligibility criteria:
inclusion criteria: * 18 to 65 years of age * literate in english (i.e., read study materials at 6th grade level) so as to understand, and complete the ratings scales and questionnaires accurately * physician-diagnosed asthma requiring treatment in the past year with a post bronchodilator fev1/fvc \>0.70 and at least 12% reversibility after bronchodilator usage * alcohol usage groups: 1) those who rarely or who do not drink alcohol (≤2 drinks per month); or 2) those who drink 3 or more alcoholic beverages per day on average exclusion criteria: * social drinkers (\>2 drinks in a month but \<3 drinks per day) * asthma exacerbation within the past month * current upper respiratory infection * active allergies with uncontrolled symptoms * current dsm-iv diagnosis of illicit substance dependence (not alcohol) * history of serious pulmonary problems other than asthma * other significant non-pulmonary comorbidities * pregnancy or currently lactating * daily use of prednisone or other corticosteroids * tobacco smoking within the past year or \>10 life-time pack-years of smoking * positive breath alcohol level at the time of the study assessments * positive urine cotinine test at enrollment (indicates nicotine usage)

Keywords: asthma, alcohol