Kornimate/medical-research-clean huggingface dataset:
development and validation of the periodontal aesthetic perception scale in patients with periodontal problems

Conditions: Gingival Enlargement; Gingival Recession

Summary: aesthetics for individuals become increasingly important, while the aesthetic effects of periodontal disease is an important issue that should be assessed by the patient's perception. the results demonstrate that the periodontal aesthetic perception scale showed reliable and valid scores in healthy controls and periodontal patients. the periodontal aesthetic perception scale may be an appropriate tool to assess periodontal esthetic in clinical and research settings.

aim: the aim of this study is to develop and validate a periodontal aesthetic specific tool to assess aesthetic conditions perceived by patients with periodontal problems. methods: with patient interviews were identified a total of 22 statements that describe the non-aesthetic gingival appearance. these 22 items were reviewed by the dentists and then periodontologists and the number of items in the survey was reduced to 7. subsequently, three groups of patients were included in the study: gingival recession (gr) group, gingival enlargement (ge) group and periodontal healthy (h) group. consequently, the validity and reliability of the periodontal aesthetic perception scale (paps) were examined. results: according to the results of the exploratory factor analysis (efa), 1 item was removed from the scale. the final 6-item questionnaire was shown to have a two-domain structure. cronbach's alpha for the whole scale was .766. the interclass correlation coefficients (iccs) values were between 0.98 and 1.00, demonstrating excellent agreement. overall, these findings indicated that the paps has good reliability. conclusion: this reliable, valid and short questionnaire specific to aesthetic conditions perceived by patients with periodontal problems may serve as a valued instrument in future clinical trials.

Eligibility criteria:
inclusion criteria for gingival recession group: - the presence of gingival recession (miller class i, ii, iii, or iv) in maxillary and mandibular anterior teeth. inclusion criteria for gingival enlargement group: -the presence of gingival enlargement (grade 0, i, ii, iii, or iv) in maxillary and mandibular anterior teeth. exclusion criteria for all groups: * the presence of prosthesis, tooth loss or caries in the anterior teeth * the precence of the psychological or systemic disease

Keywords: aesthetic development periodontal reliability validity
the short and long-term cardiovascular consequences of critical illness: the c3 study

Conditions: Critical Illness; Myocardial Infarction; Stroke; Atrium; Fibrillation; Atrial Flutter

Summary: the aim this study will be to find out which patients are at risk of heart attacks/strokes up to several years after discharge from an icu. this study will also investigate whether treatments and events occurring in icu contribute to this risk.

undertake a retrospective observational cohort study of patients admitted to intensive care units between 2006 and 2023. study participants: adult patients admitted to a general adult intensive care unit at one or more of the study sites between 2006 and 1st of august 2023. objectives: to determine the short and long-term cardiovascular consequences of critical illness and identify in-icu factors that affect them. to identify the risk factors for new-onset atrial fibrillation/flutter occurring during critical illness. to study the association between poor cardiovascular function during critical illness and long-term cardiovascular disease. this study will provide new knowledge about the associations between baseline cardiovascular risk, the disease resulting in icu admission and therapies / events on icu with subsequent major adverse cardiac events (mace), to allow the ongoing risk of these events to be determined. if clinicans can idetnify who is at risk, then risk factors can potentially be modified .

Eligibility criteria:
inclusion criteria: * aged 16 years or above. * admitted to an intensive care unit at a study site from 2006 onwards exclusion criteria: * patients that have informed their participating site that they do not wish their electronic records would be used for future research * patients who inform us directly that they don't wish their records used in this research study
new mri biomarkers in head and neck cancers

Conditions: Head and Neck Cancer; Thyroid Cancer

Summary: magnetic resonance imaging (mri) is a diagnostic technique that takes pictures of organs of the body. it uses magnetic fields and radio waves that cannot be felt. this makes specific organs, blood vessels, or tumors easier to see. diffusion mri lets us measure the motion of water in the tumor. the purpose of this study is to see if new mri methods can give us more information about the tumor.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * group 1 patients: presence of a suspicious metastatic lesion or suspicious for recurrent disease in the head and neck region. * group 2 patients: * biopsy proven recurrent or metastatic or definitive head and neck cancer or (differentiated and undifferentiated) thyroid cancers in the head and neck region only. * patients planning to undergo reatment at msk exclusion criteria: * patient would require anesthesia for the study * patients who are claustrophobic * patients selecting treatment outside of msk * known reaction to gd based contrast agent * patients who have presence of a known contradiction to mri * pacemaker * aneurysm clips * patients with implants that are contradicted for mr imaging will be excluded * pregnant * age and mental status wherein he /she is unable to cooperate for mri study

Keywords: (dw)-mri oncological biomarkers metastatic recurrent 18-063
a research study looking at how oral semaglutide works in people with type 2 diabetes in denmark, as part of local clinical practice

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to collect information on how rybelsus® works in people with type 2 diabetes and to see if rybelsus® can lower their blood sugar levels. participants will get rybelsus® as prescribed to them by the study doctor. the study will last for about 8-10 months. participants will be asked to complete a questionnaire about how they take their rybelsus® tablets. participants will complete this questionnaire during their normally scheduled visit with the study doctor. participants will be asked to complete some questionnaires about their diabetes treatment. participants will complete these during their normally scheduled visits with the study doctor.


Eligibility criteria:
inclusion criteria: * signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol) * diagnosed with type 2 diabetes mellitus * the decision to initiate treatment with commercially available oral semaglutide has been made by the patient/legally acceptable representative (lar) and the treating physician based on local label before and independently from the decision to include the patient in this study * male or female, age above or equal to 18 years at the time of signing informed consent * available hba1c value less than or equal to 90 days prior to the 'informed consent and treatment initiation visit' (v1) or hba1c measurement taken in relation with the 'informed consent and treatment initiation visit'(v1) if in line with local clinical practice * treatment naïve to injectable glucose-lowering drug(s). an exception is short-term insulin treatment for acute illness for a total of less than or equal to 14 days exclusion criteria: * previous participation in this study. participation is defined as having given informed consent in this study * treatment with any investigational drug within 30 days prior to enrolment into the study * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
an extension study of the long-term safety, tolerability, and efficacy of tividenofusp alfa (dnl310) in participants with mucopolysaccharidosis type ii (mps ii) from study dnli-e-0002 or study dnli-e-0007

Conditions: Mucopolysaccharidosis II

Summary: this is a multiregional open-label extension (ole) to assess the safety, tolerability, and efficacy of long-term treatment with tividenofusp alfa (dnl310), an investigational central nervous system (cns)-penetrant intravenous (iv) enzyme replacement therapy (ert) for hunter syndrome (mps ii). participants who complete at least through the week 49 visit in study dnli-e-0002 and do not discontinue study intervention early and participants who complete study dnli-e-0007 will be enrolled in this ole. all participants will receive dnl310 for up to 5 years from the time of entry in this ole. participants, site staff, and the sponsor will remain blinded to the original treatment assignment for participants entering this ole from study dnli-e-0007.


Eligibility criteria:
key inclusion criteria: * for participants from study dnli-e-0002 only: completed at least through the week 49 visit in study dnli-e-0002 and did not discontinue study intervention early * for participants from study dnli-e-0007 only: completed the treatment period of 96 weeks in cohort a for nmps ii participants and 48 weeks in cohort b for nnmps ii participants key exclusion criteria: * unstable or poorly controlled medical condition(s) or significant medical or psychological comorbidity or comorbidities that, in the opinion of the investigator, would interfere with safe participation in the trial or interpretation of study assessments

Keywords: hunter syndrome mps ii nmps ii nnmps ii
frailty index as an indicator associated with postoperative adverse outcomes in the older population

Conditions: Frailty

Summary: this study is a observational study in china, which aims to explore the predictive effect of preoperative frailty defined by the modified frailty index in predicting postoperative survival and complications in elderly patients. the objectives of the study include: 1. to demonstrate that the frailty scale can predict short- and long-term survival after surgery in elderly surgical patients; 2 demonstrated that frailty as defined by this scale is associated with postoperative complications in older patients

traditionally, frailty has been described as the form of chronological age. evaluating the patient's risks based solely on age is difficult, several other factors contribute to physiologic aging and determine functional reserve and response to the risk of postoperative complications. to meet the clinical demand for simpler frailty measurement tools, a simplified 5-index modified frailty index (mfi-5) has been proposed and validated in many literatures. however, there is a lack of evidence on the link between preoperative weakness and poor prognosis in elderly patients undergoing non cardiac surgery. therefore, the purpose of this study is to verify the prognostic value of mfi-5 for short-term and long-term adverse outcomes such as postoperative delirium, anxiety, depression, acute pain, and mortality in elderly non-cardiac surgery patients. our hypothesis is that frailty may be highly correlated with postoperative mortality and adverse outcomes in elderly patients undergoing non-cardiac surgery, and that mfi-5 may be an effective risk prediction tool for decision-making and surgical planning.

Eligibility criteria:
inclusion criteria: (1) participants ≥ 65 years of age; exclusion criteria: 1. lacked any covariate indicator or missing data for any confounder (such as demographic information, intraoperative surgery or anesthesia information); 2. asa physical status ⅴ; 3. anesthesia other than general intravenous anesthesia or intravenous inhalation anesthesia; 4. surgery time ≤ 60 min.
effect of smoking on periapical healing after nsrct

Conditions: Apical Periodontitis

Summary: goal of this prospective observational study is determine effect of smoking on periapical healing after nsrct. population includes systemically healthy smokers with radiographic evidence of apical periodontitis will be recruited and compared with same type of population of non smokers after non surgical root canal treatment intervention in both the groups. outcome will be assessed using periapical index scoring system at 6 and 12 months follow up period

the clinical and radiological success of primary non-surgical endodontic treatment in smoker \& nonsmoker patients will be compared between both groups and smoking cessation effect on periapical healing will be assessed. the correlation between the self-reported smoking status \& smoking status by urine analysis

Eligibility criteria:
inclusion criteria: * systemically healthy patients of age 18 years and above, known current smoker patient , a non-smoker or former smoker patient ,should have at least minimum 8 teeth in oral cavity, requiring periapical radiographs of teeth with periapical pathosis exclusion criteria: * pregnant or patient having systemic disorders, those patients who are non-compliant and not maintaining oral hygiene, teeth requiring retreatment and having procedural errors. teeth that are not suitable for rubber dam isolation, teeth that have advanced periodontal disease and having endo-perio lesions and, patients requiring endocarditis prophylaxis

Keywords: apical periodontitis, periapical pathology, smokers, non-smokers
nurse health pilot: feasibility and acceptability of a virtual act-intervention in nurses during covid-19

Conditions: Stress

Summary: frontline nurses increasingly face challenges between executing their jobs to the best of their ability and caring for their own physical and mental health. such a stressful and fast-changing work environment impacts the nurses' psychological wellbeing, resulting in high levels of stress and burnout, which in turn negatively affects patient care and outcomes. the aim of this study is to investigate whether a short virtual intervention, based on acceptance and commitment therapy (act) and adapted to caregivers, can lead to a reduction in psychological distress that may be associated with caregiving during the covid-19 pandemic. the intervention will be held online in a group setting during two half-day workshops using a conference application (e.g. zoom). note: this study is part of an international joint research project "nurse health" between the faculty of psychology (university of basel) and the nethersole school of nursing (chinese university of hong kong), funded by the swiss state secretariat for education, research and innovation (seri), with the leading house for the bilateral science and technology cooperation programme with asia at eth zürich (project no. cov_09_062020).


Eligibility criteria:
inclusion criteria: * at least 18 years of age * degree in nursing * working 40% or higher in a team of nurses in the somatic area * currently or previously in contact with covid-19 patients * working in switzerland exclusion criteria: * working in non-somatic areas (e.g. psychiatry) * working in non-hospital environments (e.g. home treatment) * not owning an electronic device * unable to understand and speak german

Keywords: stress resilience wellbeing
radiofrequency neurotomy in relieving chronic knee pain

Conditions: Osteo Arthritis Knee; Pain, Chronic

Summary: osteoarthritis (oa) affects aged above 45 years. rf has been used for several painful conditions. there have been a few attempts to use rf current for the treatment of painful conditions of joints of the extremities. it was also used for the treatment of painful conditions of the hip joint.

osteoarthritis (oa) is commonest chronic arthritis affecting patients usually aged above 45 years. oa decreased health-related quality of life and increased economic costs. radiofrequency (rf), was used for the treatment of chronic pain unresponsive to conservative therapies. rf has been used for several painful conditions. there have been a few attempts to use rf current for the treatment of painful conditions of joints of the extremities. it was also used for the treatment of painful conditions of the hip joint.

Eligibility criteria:
inclusion criteria: * chronic arthritis according to the american college of rheumatology criteria * diagnosed radiologically patients in stage 3 and 4, according to the kellgren-lawrence classification exclusion criteria: * other causes of pain such as radiculopathy, neurological disorders, or intermittent claudication. * patients receive intraarticular steroid or hyaluronic acids during previous three months. * patients did previous knee surgery. * patients with general contraindication to the application of invasive intervention such as hemorrhage, coagulation disorder, systemic infection or local infection. * patients with other connective tissue disease affecting the knee. and 6-psychiatric disorders.
anteab: a study of early antibiotherapy in the icu management of acute exacerbations of copd

Conditions: Chronic Obstructive Lung Disease (COLD)

Summary: intensive care unit (icu) admission for acute exacerbation of chronic obstructive lung disease (cold) is a major cause of morbidity and mortality in such patients. although bacterial of mortality in such patients. although bacterial and or viral infections are considered as the major precipitating factor, the antibiotic strategy in this setting is unclear. the absence of overt infection remains controversial, and has not been adequately studied in patients admitted to the icu. to assess the benefit ( or lack thereof ) of routine early systemic antibiotic therapy in patients with cold admitted to the icu. the primary objective of the essay is to evaluate the effectiveness of the precocious antibiotic therapy on the length of the respiratory symptoms with the admitted patients in polyvalent medical intensive care of chronic obstructive lung disease ( cold )

this is a multicenter, randomised, double-blind controlled trial, comparing amoxicillin-clavulanic acid administered for 7 days to a placebo.

Eligibility criteria:
inclusion criteria: * patients included are those with documented or suspected cold, exclusive of other bronchial or lung disease, and admitted for acute exacerbation, in the absence of overt sepsis or broncho-pneumonia, and having no other organ. exclusion criteria: * patients recently hospitalised, having received antibiotics since more than 24h, or on long-term steroids will not be included

Keywords: chronic obstructive lung disease (cold) randomized clinical trial antibiotics acute exacerbation mechanical ventilation intensive care length of stay mortality
to determine the safety and immunogenicity of an oral(whole cell) euvichol cholera vaccine in healthy adult men

Conditions: Prevention Harmful Effects

Summary: to determine the safety and immunogenicity of an oral(whole cell) euvichol cholera vaccine in healthy adult men

this clinical trial is open, non-comparative phase 1 clinical studies in healthy men and has been designed to determine the safety and immunogenicity of euvichol(oral cholera vaccine)

Eligibility criteria:
inclusion criteria: * adult men over 20years of age * more than 45kg body weight and ideal body weight within ±20% of the weight * screening was conducted within 14 days of investigational drug administration (vital sign \& physical examination, hematology and blood coagulation tests, blood chemistry tests, urinalysis, 12-lead ecg, etc.), the results at the discretion of the investigator deemed suitable for participation in clinical trials * written consent person who determines to participate in a clinical trial exclusion criteria: * a person who showed hypersensitivity when other preventive vaccination in the past * a person who have received cholera vaccine in the past * a person who had a febrile illness or infection disease, or have received antibiotics within 2weeks before the start of the experiment * a person who had gastrointestinal symptoms such as diarrhea, abdominal pain, or have been received prescription drug within one week before the start of the experiment * a person who was lasted for more than two weeks of symptoms such as diarrhea, abdominal pain within 6months before the start of the experiment * a person who donate whole blood or component of blood within one months before the start of the experiment if the donors * a person who received other preventive vaccine within 2months before the start of the experiment * a person who received blood products of immune globulin preparations within 3months before the start of the experiment * a person who has immune function disorders or are receiving immunosuppressive treatment * a person who has chronic illness in progress * ongoing drug and alcohol abuse(not more than 28 units/week for drinking) * a person who participate in clinical trials treated with the investigational drug within 2months before the start of the experiment * a person who is difficult to participate in this clinical trials as the discretion of the investigator

Keywords: ocv cholera
semaglutide and polycystic ovarian syndrome: an emerging treatment strategy

Conditions: Polycystic Ovary Syndrome

Summary: the purpose of this study is to investigate the effect of semaglutide in women with polycystic ovarian syndrome(pcos ) and determine potential therapeutic benefits.

the study mainly focused for the following objectives: to determine the effect of semaglutide on ovulation and menstrual regularity. to determine the effect of semaglutide on androgen levels, namely testosterone, sex hormone binding globulin, and changes in hirsutism. to determine changes in weight, body mass index (bmi), and glycated hemoglobin( hba1c) with semaglutide therapy.

Eligibility criteria:
inclusion criteria: * age 18-45 * body mass index(bmi) \> 30 * diagnosis of pcos * normal thyroid stimulating hormone, prolactin, follicle-stimulating hormone (fsh), estradiol, and normal progesterone exclusion criteria: * medications excluded: any hormone-containing contraceptive - oral contraceptive pills, progesterone-only pill, depo-provera, oral provera, progesterone-containing intrauterine contraceptive device * letrozole, clomiphene citrate, fsh therapy * androgen receptor blockers * 5α reductase inhibitors * insulin * hysterectomy * endometrial ablation