Kornimate/medical-research-clean huggingface dataset:
effect sglt2 inhibitors on contrast medium induced acute kidney injury

Conditions: Chronic Kidney Diseases; Type2diabetes

Summary: chronic kidney disease and type 2 diabetes mellitus patients are with in high-risk patients in coronary arterial diseases and increasing number of coronary angiography and coronary interventional procedures have been performed in these population. as well as the risk factors have been identified by many studies preventive measures are lacking. in our study we found that sglt2 inhibitors are beneficial in terms of reducing contrast media induced acute kidney injury in both diabetic and ckd patients.this is one of the leading studies in the literature pointing that sglt2 inhibitors may have a potentially beneficial role in reducing or preventing the development of pc-aki.


Eligibility criteria:
inclusion criteria: * patients who underwent coronary artery imaging or percutaneous coronary intervention procedures using contrast media * patient ages were between 18 and 75 years * estimated glomerular filtration rates (egfrs) between 25 and 115 exclusion criteria: * patients with acute myocardial infarction, acute renal injury, history of kidney transplantation, severe heart failure (hf, new york heart association iv), malignancy, also patients who received other pc-aki preventive medications like as n-acetylcysteine, sodium bicarbonate, or incomplete medical records were excluded from the analyses.

Keywords: sodium-glucose co-transporter inhibitor post-contrast acute kidney injury contrast media diabetes mellitus chronic kidney disease
supermicrosurgical lymphvenous bypass intervention for treatment

Conditions: Lymphedema of Leg

Summary: background: in addition to antegrade anastomosis, retrograde anastomosis has been thought to offer further improvements after lymphaticovenous anastomosis (lva) by bypassing the retrograde lymphatic flow. however, this concept has yet to be validated. the aim of this study was to determine the impacts on outcomes of performing both retrograde and antegrade anastomosis, as compared to antegrade-only anastomosis for treating lower limb lymphedema.


Eligibility criteria:
inclusion criteria: * lower limb lymphedema patients. exclusion criteria: * patients who have had previous lva, liposuction, or excisional therapy such as the charles procedure were excluded.
modular cognitive behavioral therapy for the treatment of child anxiety disorders in elementary school settings

Conditions: Separation Anxiety Disorder; Generalized Anxiety Disorder; Social Phobia

Summary: although cognitive behavioral therapy (cbt) has been found to be efficacious in the treatment of child anxiety disorders, little progress has been made in the dissemination of such treatments to real-world practice settings. clinical trials conducted in practice settings can demonstrate the degree to which evidence-based treatments are appropriate for larger scale dissemination. this study evaluates cbt as a treatment for child anxiety disorders in the elementary school clinic setting. a randomized, controlled trial design has been employed, comparing immediate treatment and a three-month waitlist. the trial is being conducted in several los angeles area elementary schools and is only available to children in these particular schools. to ensure that the cbt intervention is flexible and capable of matching the characteristics of various school settings, clinicians, and referred children, a modular treatment approach is employed. the study design includes elements to ensure high quality data, such as the use of independent evaluators and tests of treatment fidelity. children, ages 5 to 12 years, are referred by teachers and staff or are identified as having high anxiety in concurrent studies. all participating children have dsm-iv diagnoses of separation anxiety disorder, generalized anxiety disorder, or social phobia, according to a semi-structured diagnostic interview. therapy and clinical supervision is provided by the research team. it is hypothesized that children receiving immediate treatment will have significantly lower anxiety scores than children assigned to the waitlist at the posttreatment/postwaitlist assessment. if results are favorable, further exploration of dissemination of cbt into school clinic settings may be indicated.


Eligibility criteria:
inclusion criteria: * the child meets dsm-iv criteria for separation anxiety disorder (sad), social phobia, or generalized anxiety disorder (gad) based on a diagnostic interview * the child is not taking any psychiatric medication at the initial assessment, or is taking a stable dose of psychiatric medication (i.e., at least one month at a stable dose prior to the baseline assessment) * if medication is being used, children will maintain that dose throughout the study exclusion criteria: * the child is currently in psychotherapy * the family is currently in family therapy or a parenting class * the child begins taking psychiatric medication or increases his/her dose of medication during the intervention * for any reason the child or parents appear unable to participate in the intervention program.

Keywords: cognitive behavioral therapy anxiety disorders school-based intervention randomized, controlled trial
physical activity monitoring in frailty and falling

Conditions: Fraility; Risk of Falling

Summary: biosensics has developed a physical activity monitoring system (pamsys) that consists of a single wearable motion sensor that is worn on the torso. the objectives of this observational study are the following: 1) to test the efficacy of pamsys for objectively assessing a persons risk of falling based on activity data measured during activities of daily living and 2) to test the efficacy of pamsys for identifying precise early physical activity or functioning indicators of frailty in those who are pre-frail or frail as compared to non-frail controls.


Eligibility criteria:
inclusion criteria: * community-dwelling ambulatory men or women ages 65 and above exclusion criteria: * mental status mini exam score \< 23 * those who are unwilling or unable to comprehend informed consent
a study for adults undergoing magnetic resonance imaging (mri) for known or highly suspected brain and/or spinal cord conditions

Conditions: For Contrast-enhanced Magnetic Resonance Imaging (MRI) of Central Nervous System (CNS) Lesions

Summary: the purpose of this study is to evaluate the efficacy and safety of hrs-9231 for central nervous system (cns) magnetic resonance imaging (mri); to explore the effective dose of hrs-9231 for cns mri; and to explore the population pharmacokinetic characteristics of hrs-9231 in cns mri subjects


Eligibility criteria:
inclusion criteria: 1. sign the informed consent form, willing to cooperate with the study, and comply with trial requirements 2. age ≥18 years, no gender restrictions 3. known or highly suspected cns lesions, with imaging showing at least one enhanced lesion 4. scheduled for cns contrast-enhanced mri for clinical needs and agree to complete two contrast-enhanced mri scans exclusion criteria: 1. clinically unstable condition or severe diseases that may affect trial results, such as inability to ensure imaging comparability or reliability of study parameters 2. moderate to severe renal dysfunction, defined as agfr \< 60 ml/min 3. contraindications to mri, such as metallic implants or claustrophobia 4. history of severe allergies, including drugs, contrast agents, or other allergens 5. severe liver disease or cardiovascular disease, or related abnormal test results 6. central nervous system inflammation or recent history of stroke 7. active infectious diseases, such as hiv, hepatitis b, or syphilis 8. use of other contrast agents before or after study drug administration, or recent interventional treatments that may affect imaging comparability 9. pregnancy, breastfeeding, or plans for conception, without effective contraception measures 10. recent participation in other clinical trials or previous participation in studies involving gadolinium-based contrast agents 11. other conditions deemed unsuitable by the investigator
fabry screening study

Conditions: Fabry Disease

Summary: to determine if patients with a deficiency of alpha-galactosidase a are at-risk for cardiac complications that commonly occur in the general population

fabry disease is an x-linked deficiency of alpha-galactosidase a resulting primarily in an accumulation of globotriaosylceramide (gb3) in virtually all organs and systems. the main complications of fabry disease are a 20-fold increased risk of ischemic stroke, cardiac disease including cardiomyopathy, atrio-ventricular conduction defects, a wide variety of arrhythmias, valvular dysfunction (insufficiency or stenosis) and cardiac vascular disease as well as progressive renal failure. fabry disease cannot be easily diagnosed in patients with routine ekgs, echocardiograms or mris. screening non-selected at-risk populations of patients with ischemic stroke or cardiac disease for urinary gb3, alpha-galactosidase a activity and gla gene mutations should enable the identification of patients previously undiagnosed with fabry disease among the general population of patients with heart disease and stroke

Eligibility criteria:
inclusion criteria: * any diagnosis of heart disease. * male or female * able to donate 12 cc of whole blood and 10 cc of urine exclusion criteria: * no diagnosis of cardiac disease. * unable to donate 12 cc of whole blood and/or 10 cc of urine

Keywords: fabry, fabry disease, alpha-galactosidase a deficiency, gla gene, mutations
the orchestrate-myocarditis registry

Conditions: Myocarditis; Ischemia; Chest Pain

Summary: a retrospective, observational study consisting of patients who presents with typical/atypical chest pain and have an ensuing negative ischemic evaluation

multicenter, retrospective, observational study consisting of patients who presents with typical/atypical chest pain to the emergency department and have an ensuing negative ischemic evaluation. planned to review the subsequent diagnostic process in these patients, including patients with cmri (cardiac magnetic resonance imaging), pet (positron emission tomography) imaging for evaluation of myocarditis with the goal of quantifying the number of patients who go on to have a proven diagnosis of myocarditis that can explain their presenting symptoms.

Eligibility criteria:
inclusion criteria 1. age \>18 years 2. patients with a presentation of typical or atypical chest pain (icd-10 code r07.89, r07. 9) 3. patients with a negative ischemic workup: (including coronary artery calcium scoring/cta, mpi, nuclear stress test, lhc/angiography showing anything greater than "non-obstructive cad") exclusion criteria 1. patients with any evidence of positive ischemic workup as the cause of typical/atypical chest pain (as seen on coronary artery calcium scoring/cta, mpi, nuclear stress test, lhc/angiography) 2. previously documented history of prinzmetal angina or coronary vasospasm 3. history of prior myocardial infarction 4. history of any prior cad with severity greater than "non-obstructive cad" in all 3 coronary arteries 5. history of lvef\<40% 6. previously documented history of pericarditis 7. previously documented history of costochondritis
embryotransfer operator and pregnancy rate

Conditions: Sterility

Summary: several studies had analyzed the correlation between embryo transfer operator experience and implantation, clinical pregnancy, abortion and delivery rate. the aim of the present study is determining if the probabilities of embryo implantation and pregnancy are associated to the operator performing the embryo transfer. this study allows following more than 30 different operators in a global period of 20 years with almost 20,000 procedures.

several studies had analyzed the correlation between embryo transfer operator experience and implantation, clinical pregnancy, abortion and delivery rate. until now, the evidences are mixed and inconclusive. the aim of the present study is determining if the probabilities of embryo implantation and pregnancy are associated to the operator performing the embryo transfer. the database includes all the fresh embryo transfers, performed between january 1997 and december 2016 at humanitas fertility center after ivf-icsi cycles. only embryo transfers performed by the surgeon on duty for that day ("gynecologist of the day") will be included. secondary end point is to evaluate if it is possible to draw a learning curve for transfer in terms of pregnancies for the different surgeons. the strength of this study relies on the completeness of the preoperative factors and follow up and on the vastest dataset in literature that can permit to correct for multiple confounders and analyze a wide group of outcomes.

Eligibility criteria:
inclusion criteria: * fresh embryos' transfers * embryo transfers performed only by the surgeon on duty for that day ("gynecologist of the day") exclusion criteria: * cryo thawed embryos' transfers
comparison of elective lymph node treatment versus clinical observation in the absence of palpable lymph nodes for high risk skin squamous cell carcinoma (scc)

Conditions: High Risk Cutaneous Squamous Cell Carcinoma

Summary: this study will evaluate if there is a difference in survival between elective treatment of draining lymph nodes vs. clinical nodal observation in patients undergoing mohs surgery for high risk skin squamous cell carcinoma of the head and neck who have a normal lymph node exam. each treatment arm is accepted as a current standard of care, and the objective is to compare outcomes between the two arms.

this is a prospective, randomized, non-blinded, controlled trial of high risk head and neck cutaneous squamous cell carcinomas which will compare specific outcomes between two treatment arms. subjects are eligible patients who are sent to zitelli \& brodland pc for mohs micrographic surgery of tumors that meet our high risk criteria. these patients with clinically-negative lymph node exams will either enter into the arm of nodal observation or the arm of elective management of the neck, which is currently the standard protocol per the upmc ent department. the patients in the observation arm will have evaluation and treatment of their lymph nodes if an abnormality is detected clinically. the primary endpoint is disease-specific survival. secondary endpoints will include overall and disease-free survival, complications, and quality of life measures for each arm.

Eligibility criteria:
inclusion criteria: major criterion and at least one minor criteria * major criterion: \> 6 mm depth of invasion * minor criteria (one or more): * greater than 2cm diameter * recurrent (prior mohs, wide local excision, electrodesiccation and curettage, topical imiquimod or 5 fluorouracil, cryotherapy or photodynamic therapy) * high risk location: any portion of cutaneous lip, ear, temple, scalp * immunosuppressed host (organ transplant recipient or chronic lymphocytic leukemia) * perineural invasion (yes/no; nerve involved must be greater than 0.1mm) * direct involvement of subcutaneous tissue (clark's v), muscle, cartilage,or bone exclusion criteria: * satellite metastases * clinically abnormal lymph node exam * location other than head or neck * exclusively mucosal squamous cell carcinoma * previous head and neck radiation * in situ disease, keratoacanthoma subtypes, metatypical or collision tumors * inability of subject to give written informed consent * pregnancy

Keywords: high risk cutaneous squamous cell carcinoma selective neck dissection elective lymph node management clinical nodal observation
gluteus maximus fascia plasty flap for pilonidal sinus

Conditions: Pilonidal Sinus

Summary: surgical treatment is still gold standard for pilonidal sinus disease. several surgical techniques have been proposed to treat this disease in the last two decades. a new method - midline excision of pilonidal sinus and wound closure using gluteus maximus fascia plasty flap (gmff) - was proposed recently as a new method of treatment that results in low reccurence rate and good cosmetic results. the aim of this study is to compare a new method (gmff) with a traditional method (midline excision and primary closure) in terms of recurrence rate, complications and patient satisfaction with results.

pilonidal sinus disease (psd) is a rather rare benign condition (about 26 cases per 100,000 population) that affects primarily young adults. because of purulent nature it is treated with surgery only. traditional surgical techniques encompass midline excision of the purulent cyst and either leaving the wound "lay open" for secondary closure or midline primary closure. the latter method has a major drawback of high recurrence rate and very long healing and patient disability periods. therefore alternative techniques to close the wound after pilonidal sinus excision were proposed. in some a muscular-cutaneous flaps are created and the wound is closed in a z- or y- or other shape manner. the recurrence rate of these techniques is significantly lower than with a traditional midline closure, but healing time and final cosmetic results are far from ideal in patient view. recently a new method of wound closure was developed independently by a few groups that includes bilateral mobilisation of gluteus maximus muscles fascia and midline closure of the wound. preliminary results demonstrated that this method leads to lower recurrence rate and better cosmetic results because the natal cleft is saved.

Eligibility criteria:
inclusion criteria: 1. written informed consent 2. chronic primary or recurrent pilonidal sinus at the remission stage. 3. presence or absence of secondary orifices. 4. planned surgical treatment with excision of pilonidal sinus. 5. location of secondary orifices less than 2 cm from the natal cleft. 6. the distance between bilateral symmetrical secondary orifices less than 2 cm. 7. american society anesthesiologists (asa) score 1 to 3 non-inclusion criteria: 1. acute pilonidal sinus abscess. 2. the secondary openings (orifice) position more than 2 cm from the midline. 3. asa 4-5. 4. predictable impossibility of following the protocol. 5. pregnancy exclusion criteria: 1 the patients lost for the further observation. 2. the patient's refusal to continue participate in the investigation.

Keywords: pilonidal sinus plasty gluteus muscle fascia ano-coccygeal plasty
clinical feasibility study of the bariton™ system in obese patients

Conditions: Obesity

Summary: safety evaluation of bariatek medical gastric restriction and biliodigestive diversion device.


Eligibility criteria:
inclusion criteria: 1. male and female subjects aged between 25 and 60 years inclusive 2. a bmi between 30.0 and 40.0 kg/m2 inclusive with a history of obesity for at least 2 years and a history of failure of supervised weight loss program 3. stable weight, i.e. \< 5% change in body weight for minimum of 3 months prior to enrolment 4. willing and able to provide written informed consent 5. willing and able to comply with the study procedures and follow-up schedule
gastric volume after ingestion of carbohydrate drink vs water in obese volunteers

Conditions: Obesity; Gastric Emptying

Summary: this randomized crossover study compares gastric residual volume after ingestion of carbohydrate drinks and water in obese volunteers. the main question\[s\] it aims to answer are: * is it safe for obese patients to shorten their fasting by allowing preoperative drinks? * how long is the gastric emptying time in obese patients? participants also will be evaluated the level of thirst/hungry and blood sugar.


Eligibility criteria:
inclusion criteria: * healthy volunteers * age 18 - 65 years old * bmi ≥ 30 kg/m2 * npo for at least 6 hours before the study exclusion criteria: * diabetes mellitus * chronic kidney disease or end-stage renal disease * use of any medication that affects gastric secretion or emptying (histamine 2 receptor antagonist eg. ranitidine/proton pump inhibitor eg. omeprazole/acid neutralization eg. aluminium hydroxide/prokinetic eg. domperidone) within the past 24 hours * gastroesophageal reflux disease * pregnancy * history of upper gastrointestinal surgery * in diet program or use appetite suppressant drug (eg. liraglutide, naltrexone, phentermine, diethylpropion) within the past 24 hours

Keywords: gastric residual volume, obesity, carbohydrate drink
comparison of successful spinal needle placement between crossed leg sitting position and traditional sitting position

Conditions: Adult Patients With Spinal Anesthesia

Summary: the study aimed to compare successful spinal needle placement between crossed leg sitting position and traditional sitting position in patients underwent urology surgery.

approval from ethical committee of faculty of medicine universitas indonesia was acquired prior conducting the study. subjects were given informed consent before enrolling the study. subjects were randomly divided into clsp group for crossed leg sitting position (n=105) and tsp group for traditional sitting position (n=106). non-invasive blood pressure (nibp) monitor, eletrocardiography (ecg), oxygen nasal cannula and pulse-oxymetry was set on the subjects in the operation room. baseline information was recorded. spinal anesthesia was done by anesthesiology registrars that have done 50 spinal anesthesia procedures and have been explained about the protocol of spinal anesthesia injection in this study (to avoid bias). outcome measures were the number of successful spinal needle placement in the first attempt, the difficulty level of landmark palpation for injection, and the number of needle-bone contact. data was analyzed by spss (statistical package for social scientist) using chi-square test, fisher exact test, and kolmogorov-smirnov test. significance value used was 5% with 80% power.

Eligibility criteria:
inclusion criteria: * subjects aged 18-60 years old- * subjects with asa physical status i-iii who were planned to undergo urology surgery with spinal anesthesia * subjects who have been explained about the study, have agreed to enroll and have signed the informed consent form exclusion criteria: * uncooperative subjects * subjects with relative and absolute contraindications to spinal anesthesia (coagulation disorders, thrombocytopenia, increases intracranial pressure, severe hypovolemia, severe heart valve disorders, local infection at the injection site, allergy toward local anesthetic agents, significant anatomical disorder of the spine, wound/scar on the lumbal area) * subjects with body mass index (bmi) \> 32 kg/m2 drop out criteria: * subjects who requestes to drop out of the study * subjects in need of emergency treatment during spinal anesthesia procedure * subjects with more than nine times redirected spinal needle (failed spinal anesthesia procedure).

Keywords: spinal anesthesia sitting cross leg spinal-bone contact