Kornimate/medical-research-clean huggingface dataset:
3d assessment of mandibular bone loss via stl superimposition after complete denture occlusal adjustment

Conditions: Resorption of Mandible

Summary: stl registration-based superimposition is an advanced technique for assessing mandibular bone resorption in removable complete denture (rcd) patients. this 3d method involves aligning and comparing digital models of the mandible before and after rcd use, offering high accuracy and comprehensive analysis. the process includes 3d scanning, stl conversion, registration, superimposition, and quantification. occlusal equilibration of rcds plays a crucial role in distributing masticatory forces and influencing bone resorption patterns. studies using this technique have revealed non-uniform resorption, with variations in different regions of the mandible. while offering numerous advantages over traditional methods, challenges include potential registration errors and the need for specialized equipment and expertise. future developments may incorporate machine learning, biomechanical modeling, and long-term studies to enhance understanding and clinical application of this technology in prosthodontics and oral surgery.

stl registration-based superimposition is an innovative technique for evaluating mandibular bone resorption in patients using removable complete dentures (rcds). this 3d method aligns and compares digital mandible models from different time points, providing precise volumetric and surface change measurements. the process involves 3d scanning, stl file conversion, model registration, superimposition, and quantification. occlusal equilibration of rcds is crucial for distributing masticatory forces evenly, influencing bone resorption patterns. research using this technique has shown that mandibular bone resorption is non-uniform, with variations across different mandibular regions. while offering superior accuracy and comprehensive analysis compared to traditional methods, this approach faces challenges such as potential registration errors and the need for specialized equipment and expertise. future developments may incorporate machine learning, biomechanical modeling, and longitudinal studies to enhance understanding and clinical application in prosthodontics and oral surgery.

Eligibility criteria:
inclusion criteria * completely edentulous patients ranging from age 45 to 75 years * angle's class i skeletal relationship * normal facial symmetry * cooperative patients * adequate inter-arch space not less than 12mm exclusion criteria * temporomandibular disorders * uncontrolled diabetes * bleeding disorders or anticoagulant therapy * flabby tissues or sharp mandibular residual ridge. * heavy smokers. * patient's with neuromuscular disorders * patients on chemotherapy or radiotherapy * severe psychiatric disorders * angle's class ii and iii skeletal relationship
regulatory post marketing surveillance (rpms) study of ozempic (semaglutide) to evaluate safety and effectiveness in patients with type 2 diabetes mellitus in routine clinical practice in korea

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this study is to assess the safety and effectiveness of ozempic initiated according to label in adults with type 2 diabetes mellitus (t2dm) under routine clinical practice conditions. participants will get ozempic as prescribed by study doctor. the study will last for about 26 weeks.


Eligibility criteria:
inclusion criteria: * the decision to initiate treatment with commercially available ozempic has been made by the participant/legally acceptable representative (lar) and the treating physician before and independently from the decision to include the participant in this study. * the participant with t2dm is scheduled to start treatment with ozempic based on the clinical judgment of their treating physician as specified in the approved label in korea. * informed consent is obtained before any study-related activities. study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * male/female age greater than or equal to (\>=) 19 years at the time of signing informed consent. exclusion criteria: * participants who are or have previously been on ozempic therapy. * known or suspected hypersensitivity to ozempic, the active substance or any of the excipients. * previous participation in this study. participation is defined as having given informed consent in this study. * female patients who is pregnant, breast-feeding or intends to become pregnant and is of child-bearing potential and not using adequate contraceptive methods (adequate contraceptive measures as required by korea regulation or practice). * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation.
efficacy of flow ball phonation in professional voice users

Conditions: Prevention of Voice Disorders in Professional Voice Users; Treatment of Functional Voice Disorders in Professional Voice Users

Summary: the aim of this study is to investigate the effects of flow ball phonation on the voice of professional voice users and elite vocal performers, both with and without functional voice disorders. given the substantial vocal demands inherent to this population and their reliance on the voice for occupational purposes, this intervention may represent a valuable approach for the prevention and/or treatment voice disorders.

background. due to the high vocal demands, professional voice users (e.g. teachers) and elite vocal performers (e.g. singers) are risk populations for developing voice disorders. high-quality voice research in these vulnerable populations is highly needed for effective and efficient treatment and prevention of voice disorders. the flow ball (fb) is a promising innovative voice therapy device to perform semi-occluded vocal tract exercises (sovte) with the extra advantage of providing real-time visual feedback of the airflow. despite this important advantage, strong efficacy studies of an fb intervention program are lacking. objective. to investigate the immediate-, short- and long-term effects of an sovte intervention with the fb on the phonation of professional voice users with (treatment) and without (prevention) voice disorders and to compare it with the 'treatment as usual' straw phonation (sp) and a sham condition, using a longitudinal randomized sham-controlled trial (rct). methods. subjects will be randomly assigned into an fb group, an sp group or a control (sham) group. they will receive a short-term intensive voice intervention of 3 weeks, combining both guided therapy/training sessions and independent practice at home. a flexible strobovideolaryngoscopy and a multidimensional voice assessment will be performed by assessors blinded to group allocation and study phase. assessments will be performed two times before the intervention (pre 1 and pre 2), immediately after the intensive intervention (post 1) and at 3 weeks (follow-up 1) and 3 months (follow-up 2) follow-up. the sham group will use the same fb device but no phonation will be involved.

Eligibility criteria:
objective 1: treatment inclusion criteria: * all genders * all ethnicities * 18 - 60 years * diagnosis of a functional voice disorder * professional voice users exclusion criteria: * diagnosis of an organic voice disorder * current participation in voice therapy * previous phonosurgical interventions * pregnancy * smoking * nasal or ear diseases * neurological disorders objective 2: prevention inclusion criteria: * all genders * all ethnicities * 18 - 60 years * professional voice users exclusion criteria: * current or previous diagnosis of a voice disorder * current or previous participation in voice therapy * previous phonosurgical interventions * pregnancy * smoking * nasal or ear diseases * neurological disorders

Keywords: flow ball sovte professional voice users straw phonation
a study of avutometinib + defactinib in recurrent low-grade serous ovarian cancer in japanese patients

Conditions: Low Grade Serous Ovarian Cancer; Ovarian Cancer

Summary: this study will confirm the safety and efficacy of avutometinib in combination with defactinib in japanese patients with recurrent low-grade serous ovarian cancer (lgsoc)

this is a multi-center, open label phase 2 study designed to evaluate safety and tolerability and confirm efficacy by bicr of avutometinib in combination with defactinib in japanese patients with molecularly profiled recurrent lgsoc.

Eligibility criteria:
inclusion criteria: * histologically proven lgsoc (ovarian, peritoneal) * documented mutational status of kras by validated diagnostic test of tumor tissue * documented disease progression (radiographic or clinical) or recurrence of lgsoc and have received at least one platinum-based chemotherapy agent * measurable disease according to recist 1.1 * an eastern cooperative group (ecog) performance status ≤ 1. * adequate organ function * adequate recovery from toxicities related to prior treatments * agreement to use highly effective method of contraceptive, if necessary exclusion criteria: * systemic anti-cancer therapy within 4 weeks of the first dose of study therapy * co-existing high-grade ovarian cancer or another histology * history of prior malignancy, excluding ovarian cancer, with recurrence \<3 years from the time of enrollment * major surgery within 4 weeks * symptomatic brain metastases requiring steroids or other interventions * known sars-cov2 infection (clinical symptoms) ≤28 days prior to first dose of study therapy * for subjects with prior mek exposure, grade 4 toxicity deemed related to the mek inhibitor * active skin disorder that has required systemic therapy within the past year * history of rhabdomyolysis * concurrent ocular disorders * concurrent heart disease or severe obstructive pulmonary disease * patients with the inability to swallow oral medications

Keywords: kras kras wt kras mt
optimal timing of zoster vaccine after zoster illness

Conditions: Shingles

Summary: the purpose of this study is to determine the optimal timing of zoster vaccination to induce both higher cell-mediated immunity and humoral immunity in adult patients aged over 50 with history of zoster within 5 years.

zoster vaccination is recommended by fda for adults aged 60 years or older, and is approved for people aged 50 through 59 years old. for patients who had shingles, there is no specific length of time they must wait before receiving shingles vaccine. it is generally recommended that patients should wait for 6 to 12 months after recovery. the investigators plan to make scientific recommendation for optimal timing of zoster vaccine after zoster illness by comparing immune response between two groups (vaccination at 6 months to 2 years after shingles vs. 2 to 5 years after shingles). primary outcome is elispot response at week 6 after vaccination. secondary outcome is gpelisa titer at week 6 after vaccination. all the patients will be asked if they have any contraindications for zoster vaccine by a physician before vaccination. and they will be monitored for any adverse reaction of the vaccination after 6 weeks (visiting the hospital).

Eligibility criteria:
inclusion criteria: * adults aged 50 years or older who have had shingles in 5 years * adults who did not receive zoster vaccination yet * adults who can understand and agreed with the informed consents. exclusion criteria: * adults who have conditions which is contraindication for zoster vaccine * adults who had zoster vaccination already * adults who take immunosuppressants * human immunodeficiency virus (hiv) patients whose cd4 t cell counts below 500/mm3 * adults with autoimmune disease who are anticipated to have a problem with immunogenicity for vaccine * adults who had organ transplantation and receive immunosuppressants * adults who are suspected to have active infectious disease * adults who are not eligible for zoster vaccination by investigator's assessment

Keywords: herpes zoster vaccine cell-mediated immunity
the comparison of desflurane and sevoflurane on postoperative recovery and hepatic function of biliary atresia patients during kasai operation

Conditions: Kasai Operation; Biliary Atresia

Summary: biliary atresia (ba) is a perinatal disease of unclear etiology, characterized by inflammation and obliteration of intrahepatic and extrahepatic bile ducts, leading to cholestasis and cirrhosis. kasai operation remains as the first line operative treatment in ba. in the previous studies, inhalation anesthetics might induce liver damage. the choice of inhalation anesthetic that minimally affects hepatic function is important. therefore, the purpose of this study is to compare the postoperative recovery and hepatic function between desflurane and sevoflurane, two most frequently used inhalational anesthetics in patients undergoing kasai operation.


Eligibility criteria:
inclusion criteria: * patients with biliary atresia undergoing kasai operation exclusion criteria: * patients with congenital anomalies at major organs

Keywords: kasai operation under general anesthesia
a study of inhaler use in the community

Conditions: Asthma; Chronic Obstructive Pulmonary Disease; Airways Disease

Summary: this is a prospective cohort observational study of inhaler adherence in a community care setting (ie. general practice clinics and pharmacies in the community).

over a 2-4 week period, consecutive patients with a history of respiratory illness already prescribed a salmeterol/fluticasone diskus inhaler will be asked to participate in this study. patients will give informed consent to participate in this study of adherence, which will be assessed with the inca device. both clinicians and patients will be fully aware that the device is an acoustic recording device and that both time and technique of inhaler use will be assessed. once consented, patients will be given an inca enabled inhaler for 1 month and asked to use it as they normally would and then to return it at the end of one month. the days used and the number of doses used in the study period, as per the dose counter, will also be recorded.

Eligibility criteria:
inclusion criteria: * known history of respiratory illness * prescribed salmeterol/fluticasone diskus inhaler exclusion criteria: * unable to understand study protocol * refusal to sign consent form

Keywords: asthma inhaler use adherence chronic obstructive pulmonary disease
transobturator approach for paravaginal repair

Conditions: Cystocele

Summary: a new technique for applying sutures to the white line in paravaginal repair.

a new trial for transobturator repair of the paravaginal defect.

Eligibility criteria:
inclusion criteria: * paravaginal defect cystocele * midline and paravaginal defect cystocele exclusion criteria: * uterine descent * previous cystocele surgery
malaria genetic surveillance in cambodia

Conditions: Parasitology; Entomology; Malaria

Summary: this study is to determine the prevalence and geographical distribution of antimalarial drug resistance-linked genetic mutations in clinical p. falciparum infections in cambodia

this is a prospective observational study of patients with clinical plasmodium falciparum infection using parasite dna from point-of-care fingerprick dried blood spot samples as well as a short survey on patient demographics, employment, travel, and mobile phone use to study p. falciparum parasite genotypes, population characteristics, and gene flow patterns. on inclusion in the study and before standard treatment is administered, dried blood spots (dbs) will be obtained through fingerprick blood sampling from patients, with three blood spots on one piece of filter paper being obtained from each patient. each blood spot will contain \~20µl of blood, for a total of \~60µl of blood being collected from each patient for the study. in order to have a greater understanding of the possible sites of malaria transmission and to relate genetic diversity to geographic location, patients or their parents/guardians will also be asked a short set of questions on demographics, their places of residence and work, recent mobile phone use, and their history of travel in the last 2 months. as some of this information can be sensitive, during the consent process the patient will be given the option of not providing some or all of this information without needing to provide a reason. this is explained on the patient information sheet. for those who do not want to provide information, this will be documented in the survey form. a duplicate of the sample barcode will be placed on this same form, so the information therein can be matched with the relevant blood spot and its related genetic data, while retaining sample anonymity.

Eligibility criteria:
inclusion criteria: * male or female \>6 months of age * p. falciparum malaria as confirmed by positive rapid diagnostic test or asexual forms of p. falciparum on blood smear microscopy (may be mixed with non-falciparum plasmodium species) * written informed consent by patient, parent/guardian, or legally authorised representative to participate in the study exclusion criteria: • none

Keywords: malaria genetic surveillance cambodia
effect of different fluid ingestion rate on post-exercise rehydration

Conditions: Dehydration

Summary: the purpose of the present study is to investigate the effect of different rate of fluid consumption on post-exercise rehydration.

the body water deficits equivalent to 2% body mass might impair performance. due to high exercise intensity, thermal environment, or rule limitation, athletes often in dehydration status post-exercise. thus, how to rehydrate effectively to prepare the next game is important. the participants arrived to the lab euhydrated and were dehydrated to 2% of body weight by running. after a rest, they will ingest sports drink in a volume equivalent to 150% of bw loss in 30 min, 60 min, or 90 min. urine and blood sample will be collected to evaluate hydration status.

Eligibility criteria:
inclusion criteria: * 20\~35 years old male * exercise 150 min per week * without chronic disease or gastrointestinal surgery exclusion criteria: * injury * answer "yes" in part 1 of the physical activity readiness questionnaire(par-q+) * participate in other studies within one month

Keywords: sports nutrition dehydration sports medicine rehydration ingestion rate
effect of prebiotics versus low fodmaps diet on intestinal microbiota and symptoms

Conditions: Functional Gastrointestinal Disorders

Summary: it has been shown that patients complaining of gas-related symptoms significantly improve on a diet low in fermentable residues. however, other studies suggest that some non-absorbable, fermentable meal products (prebiotics) that serve as substrate to colonic bacteria, produce beneficial effects to the host, including improvement of abdominal symptoms. the aim of the study is to compare the effects of a diet low in fermentable residues versus a diet suplemented with prebiotics on intestinal microbiota composition, microbiota activity (intestinal gas production) and digestive symptoms.


Eligibility criteria:
inclusion criteria: * functional digestive disorder with flatulence * women and men between the ages of 18 and 80 years (bounds included at the inclusion visit). * normal body weight or with overweight (body mass index between 18.0 and 30.0 kg/m2 (bounds included)). * women of childbearing potential should be using or complying with one of the medically approved methods of contraception such as, but not exclusively, one of the following: 1. birth control pill 2. intra-uterine device (iud) 3. double barrier methods (such as condoms and spermicide) 4. abstinence * willing to follow strict dietary instructions for the duration of the study * able to communicate well with the investigator and to comply with the requirements for the study. exclusion criteria: * significant illness other than functional bowel disorders * disease/disorders which can interfere with the collection of the gas (hemorrhoids,..etc) * antecedents of digestive surgery, excluding appendicectomy * intake of antibiotics in the month (within 30 days) preceding the inclusion visit. * current use of any medications with potential central nervous system effects as judged by the investigator (including but not limited to antidepressants, anxiolytics, opiate pain medications) * taking drugs that might modify gastrointestinal function * change of dietary habits within the preceding 4 weeks (for instance start of a diet high in fiber) or planned change (for example to start a diet) during the period of the study

Keywords: intestinal microbiota intestinal gas dietary intervention low-fodmaps diet prebiotics
observational retrospective study on the clinical and radiographic outcomes of the aseptic pseudarthrosis treatment of the upper limb

Conditions: Pseudarthrosis

Summary: the aim of this study is to collect boh clinical and radiographic data coming from the treated patients for pseudarthrosis of the upper limbs from 2000 to 2017 at the sc orthopedic surgery, innovative techniques of the istituto ortopedico rizzoli in order to evaluate the clinical and radiographic outcomes of the treatment, with or without the application of biological adjuvants.

the bone healing requires the integrations of two main principles: biomechanical aspect and biological aspect. the second one has having growing interest. the use of the biological adjuvants, as growth factors (rhbmp2 and 7), platelet-derived growth factors (pdgfs), platelet gel (pg) or plasma rich fibrin (prf), as well as peptides and molecules are demonstrating promising results in the field of bone regeneration. the addition of autologous bone marrow concentrate cells has proven to be an effective option in the treatment of bone defects, although to date there is no clear superiority of one method over the other. in light of this, the purpose of the study is to evaluate the clinical and radiographic outcomes of the treatment, with or without the application of biological adjuvants, collecting data coming from the treated patients for pseudarthrosis of the upper limbs from 2000 to 2017 at the sc orthopedic surgery, innovative techniques of the istituto ortopedico rizzoli

Eligibility criteria:
inclusion criteria: * patients with post-traumatic pseudoarthrosis of the long bones of the upper limb * duration of at least 6-9 months without clinical-radiographic signs of healing in the 3 months prior to pseudoarthroses exclusion criteria: * pseudoarthrosis due to pathological fracture * infected pseudarthrosis * pseudoarthrosis treated with external fixation * bmi\> 35