Kornimate/medical-research-clean huggingface dataset:
a study of gdc-0980 in the treatment of recurrent or persistent endometrial carcinoma

Conditions: Endometrial Carcinoma

Summary: this is a multicenter, single-arm, open-label phase ii study to evaluate the activity of gdc-0980 in patients with recurrent or persistent endometrial cancer. the safety, tolerability, and pharmacokinetics of gdc-0980 will also be evaluated.


Eligibility criteria:
inclusion criteria: * patients must have recurrent or persistent endometrial carcinoma that is refractory to curative therapy or established treatments * histologic confirmation of the original primary tumor is required * histologic or cytologic confirmation of the recurrent/progressive disease is desired * patients must have had at least one but no more than two prior chemotherapeutic regimens for management of endometrial carcinoma * disease that is measurable per recist v1.1 * no active infection requiring antibiotics * any hormonal therapy directed at the malignant tumor must be discontinued at least 2 weeks prior to first study treatment * any other prior therapy directed at the malignant tumor, including immunologic agents and radiotherapy, must be discontinued at least 2 weeks prior to first study treatment * adequate hematologic and end organ function exclusion criteria: * type i diabetes or type ii diabetes requiring insulin * prior use of mtor/pi3k inhibitor * current dyspnea at rest or any requirement for supplemental oxygen therapy to perform activities of daily living * previous diagnosis of pulmonary fibrosis of any cause * history of myocardial infarction or unstable angina within 6 months prior to first study treatment * congestive heart failure * history of malabsorption syndrome or other condition that would interfere with enteral absorption * clinically significant history of liver disease, including cirrhosis and current alcohol abuse * presence of positive test results for hepatitis b or hepatitis c * known hiv infection * active autoimmune disease that is not controlled by nonsteroidal anti inflammatory drugs * need for current chronic corticosteroid therapy * pregnancy, lactation, or breastfeeding * current severe, uncontrolled systemic disease * major surgical procedure or significant traumatic injury within 28 days prior to day 1 or anticipation of the need for major surgery during the course of study treatment * uncontrolled hypercalcemia * leptomeningeal disease as a manifestation of cancer * known untreated or active brain metastases * grade \>=2 hypercholesterolemia or hypertriglyceridemia
wii aerobic training in inhalation-injury children post-thermal burn

Conditions: Inhalation Injury

Summary: inhalation injury is a composite of multiple insults including: supra glottic thermal injury, subglottic airway and alveolar poisoning, and systemic poisoning from absorbed small molecule toxins. these contaminant insults independently affect each of the pulmonary functions as well as having a direct effect on systemic physiology. further, anatomic characteristics can predispose patients to inhalation injury. for example, an infant will develop airway obstructions much faster than an adult due to reduced airway diameter. understanding the contributions of each of these pathologies to the patient's disease is critical to managing inhalation injury. wii fit aerobic training gives similar results with traditional rehabilitation practices, it causes less energy costs. this suggests that it can be a suitable rehabilitation tool for adult and elderly people with low energy levels. a review showed that video games are safe and feasible in the children with lung complications. children' balance, aerobic and cognitive functions, quality of life improved and depressive mood decreased. wii aerobic games also make children to communicate better with other family members.

this study will investigate the effects of wii aerobic training in inhalation-injury children post-thermal burn. to assign patients to different treatment groups, a table of random numbers generated by a computer was used. patients were allocated randomly into one of three groups using this method. this study will be carried out at the outpatient clinic of the faculty of physical therapy, modern university for technology and information, om el masryeen hospital and embaba general hosbital after referral from dermatologist. children will perform these exercises in a room supervisor physiotherapist. all parents of children will sign a written consent form after receiving full information about the purpose of the study, procedure, possible benefits, privacy, and use of data.

Eligibility criteria:
inclusion criteria: * six weeks after deep second-degree thermal burn with inhalation injury (until complete healing) with 35%-40% total body surface area (tbsa), burn size was measured using modified lund and browder charts. * 12 years to 17 years (child ) * inhalation injury. * all children suffering from retained secretions which did not respond to medical treatment. * all children should be clinically and medically stable. * all children should have the same medical treatment. exclusion criteria: * children with any dysfunction that limit physical activity such as neurological disorders, chronic obstructive pulmonary disease, malignancy, cardiovascular diseases, orthopedic problems, such as fracture on the pelvic or limbs, a visual impairment, brain injury or hearing impairments and contractures. * children use non-invasive mechanical ventilation and intubation or need for intensive clinical support and/or transfer to the intensive care unit. * children with other hormonal diseases
investigating the effect of herbal medicine nasal irrigation on treatment of chronic rhinitis and sinusitis

Conditions: Nasal Disease

Summary: this study investigate the nasal irrigation with traditional herbal medicine extract-saline isotonic solution in the treatment of chronic rhinitis and sinusitis. half of participants will receive traditional herbal medicine extract-saline isotonic solution nasal irrigation, while the other half will receive saline alone nasal irrigation.

in the program, the investigators plan to investigate a clinical triad to research the outcomes of nasal irrigation with traditional herbal medicine extract-saline isotonic solution for treatment of chronic rhinitis and sinusitis. the aims of this study are listed below: aim 1: evaluating the outcomes and quality of life of nasal irrigation with traditional herbal medicine extract-saline isotonic solution to treat enrolled patients with chronic rhinitis or sinusitis. the investigators use modern devices to evaluate the autonomic nerve, meridian energy and pulse. the questionnaires of quality of life and symptoms will be recorded. nasal irrigation with saline alone will be conducted during the clinical triad to compare the effectiveness and quality of life with traditional herbal medicine extract. aim 2: analyzing the changes of bacteria culture in nasal discharge collected during the clinical triad before and after nasal irrigation for investigating the microenvironment of traditional herbal medicine extract-saline isotonic solution. according to the research, the investigators will realize the improvement of using traditional herbal medicine extract-saline isotonic solution for nasal irrigation to treat sino-nasal diseases, by investigating the changes of quality of life and microenvironment of nasal cavity. the nasopharyngoscopic examination, autonomic nerve, meridian energy and pulse were record to compare the effectiveness of traditional herbal medicine extract-saline isotonic solution with nasal irrigation with saline alone.

Eligibility criteria:
inclusion criteria: 1. diagnostic criteria for chronic rhinitis and sinusitis male and female volunteers. 2. stop using oral and topical steroid and anti-histamine treatments \>2 weeks prior to enrollment. 3. \>20 years of age. exclusion criteria: 1. allergy to herbal medicine. 2. presence of a sinus tumor. 3. significant immune dysfunction. 4. pregnancy and breast-feeding women. 5. undergone nasal surgery \<1 week prior to enrollment.

Keywords: rhinitis, sinusitis, nasal irrigation, tcm
treatment of hypertension: an interventional approach to improve blood pressure control

Conditions: Hypertension

Summary: the purpose of the study is to access the change in mean daytime systolic blood pressure in participants with essential hypertension not adequately controlled (defined as mean systolic daytime ambulatory blood pressure ≥ 135 mmhg) and randomly assigned to either an intervention group with one-time only direct observed therapy (dot) immediately followed by abpm or a control group with standard abpm.

more than 1 billion people world wide suffer from hypertension (ht), leaving it the world´s top rank risk factor and contributor to global disease burden. cardiac disease, stroke, kidney disease and dementia are diseases related to ht with high economic burden on societies and each year 9.4 million people die as a direct consequence of ht. estimated \< 50 % of hypertensive patients adhere to preventive hypertensive medication after 1 year of treatment. poor adherence to antihypertensive treatment have by many been explained partly by the silent nature of hypertension, the risk of side effects from antihypertensive medication, treatment expenditures and the patient health perspectives. in a randomized controlled trial design we plan to enrol 20 subjects, the limited number explained by the study being part of the initial planning of a larger scale trial organized by the research group, to invistigate the change in ambulatory bloodpressure with or with out direct observed theraphy prior to meassurement, as a one-time-only medication adherence check.

Eligibility criteria:
inclusion criteria: * 18 years and above * residing in oslo/akershus * ambulatory systolic daytime blood pressure ≥ 135 mmhg * ≥ 2 antihypertensive medications * be able to read and write norwegian exclusion criteria: * critical illness, ongoing treatment * known atrial fibrillation * known heart valve stenosis * myocardial infarction, angina pectoris or stroke the past 6 months * known severe renal impairment (egfr \< 30 ml/min/1.73 m2) * history of dot prior to abpm * participation in other interventional study

Keywords: hypertension adherence direct observed therapy (dot) rct
study to evaluate the digestive tolerability of art44 versus art®50 in patients with osteoarthritis of the knee

Conditions: Knee Osteoarthritis

Summary: the primary objective of this study, comparing art 44 to art 50, will be the evaluation of digestive tolerability (and in particular of diarrhoea).


Eligibility criteria:
inclusion criteria: * female or male, aged 40 to 80 years, outpatient; * presenting with internal femorotibial osteoarthritis: * symptomatic for more than 6 months; * meeting acr clinical and radiological criteria; * overall mean vas score of knee pain in last 24 hours \> 40 mm (with no nsaids for over 72 hours and no analgesics for over 24 hours); * pain present for at least one day out of 2 in the month preceding enrolment; * radiological stage ii to iii (kellgren and lawrence) (image less than 12 months old). exclusion criteria: * associated predominant symptomatic femoropatellar osteoarthritis; * chondromatosis or villonodular synovitis of the knee; * paget's disease.

Keywords: knee osteoarthritis
artificial intelligence in endoscopic ultrasound

Conditions: Pancreatic Cancer; Pancreas Disease; Pancreatic Cyst

Summary: the objective of the study is to determine if this artificial intelligence system is capable of detecting abnormalities in the pancreas that are identified by an endoscopist at endoscopic ultrasound procedures.

endoscopic ultrasound (eus) is an equipment where an ultrasound transducer is attached to the tip of the endoscope. when advanced to the stomach the organs outside such as the pancreas and liver can be visualized in great detail. this enables diagnosis of conditions such as pancreatic cancer. however, an endoscopist must undergo training to accurately interpret these ultrasound images. the investigators are in the process of developing an artificial intelligence system that could potentially interpret eus images. the objective of the study is to determine if this artificial intelligence system is capable of detecting abnormalities in the pancreas that are identified by an endoscopist at endoscopic ultrasound procedures. such correlation if established will lead to possible development of an artificial intelligence platform that can diagnose pancreatic diseases. such development will potentially minimize human error and decrease learning curve to gain proficiency in eus.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * any patient undergoing endoscopic ultrasound examination exclusion criteria: * age \< 18 years

Keywords: pancreatic disease pancreatic cancer pancreatic cyst artificial intelligence
assessment of intravitreous injections of vitrase for inducing posterior vitreous detachment

Conditions: Vitreous Detachment; Diabetic Retinopathy

Summary: the purpose of this study is to assess the efficacy of intravitreous injections of vitrase to induce posterior vitreous detachment(pvd) in subjects with moderate to severe non-proliferative diabetic retinopathy.


Eligibility criteria:
inclusion criteria: * moderately severe to severe non-proliferative diabetic retinopathy * best corrected visual acuity (bcva) in early treatment diabetic retinopathy study (etdrs) with pinhole of 20/320 or better in study eye \& 20/50 or better in non-study eye. exclusion criteria: * contraindications or hypersensitivities to vitrase or anesthesia * any significant illness that could be expected to interfere with trial * prior vitrase therapy * either a past diagnosis of clinically significant macular edema (cme) in study eye that required treatment or current cme that may require focal laser treatment within the next 30 days * for either eye: ongoing ocular infection, inflammation or history of herpetic corneal lesion; an intravitreous injection within 30 days; glaucoma; intraocular pressure (iop) of less than 5mmhg; retinal detachment or ocular tumors * for study eye: vascular occlusive disease of fundus; corneal, lenticular or ocular media abnormalities; a significant ocular trauma within 6 months; previous vitrectomy; any prior laser treatment, cryo-retinopexy or any intraocular surgery; either a partial or complete posterior vitreous detachment (pvd); myopia of 6 or more spherical diopters and/or axial length exceeding 26mm; significant retinal pathology
evaluating ureteral length using computed tomography (ct)

Conditions: Ureteral Calculi; Hydronephrosis; Ureteral Obstruction

Summary: proper selection of ureteral stent length might help in reducing comorbidities associated with ureteral stenting, currently there is no standardized way of measuring ureteral length. measurement of ureteral length according to computed tomography (ct) scan might provide useful information when selecting the length of a ureteral stent. our aim in this study is to compare ureteral measurements using ct scan and measurement of actual ureteral length measured during ureteral stenting.


Eligibility criteria:
inclusion criteria: * patients undergoing planned procedure involving ureteroscopy or ureteral stenting * abdominal ct scan performed within 6 months prior to intervention exclusion criteria: * known iodine sensitivity * patients with fever or hemodynamic instability planned for urgent operation * severe immune compromized patients * severe thrombocytopenia \< 50,000
description of the use of fidaxomicin in hospitalized patients with documented clostridium difficile infection and of the management of these patients

Conditions: Clostridium Difficile Infection

Summary: the study aims to describe the characteristics and the methods of management and follow-up of patients treated with fidaxomicin for clostridium difficile infection (cdi).


Eligibility criteria:
inclusion criteria: * hospitalized patient * patient diagnosed with cdi exclusion criteria: * patient already included in this study * patient is taking part in a clinical trial in the field of cdi

Keywords: clostridium difficile infection cdi observational fidaxomicin recurrence france
assessment of the feasibility of a systematic multidimensional evaluation of the outcome of traumatic brain injury patients and their relatives.

Conditions: Traumatic Brain Injury

Summary: the main objective is to assess the feasibility of collecting and implementing a multidimensional evaluation in a sample of patients with a mild to severe traumatic brain injury (tbi) and their relatives, evaluated at 6 months (primary outcome), and at 12 then 18 months post-injury (secondary outcomes).

the study aims to assess the feasibility of collecting multidimensional outcomes of patients with traumatic brain injury, taking into account the patient-relative dyad. however, this multidimensional assessment may pose enormous problems of feasibility during the follow-up: loss of the patient's pathway, moderate acceptance by patients and relatives, difficulties of remote assessment sometimes carried out several times.... all these factors can affect the methodological quality of the evaluation of patient outcomes, with measurement and reporting biases influencing the results of biomedical trials. in order to improve the quality of clinical research in this field, it is therefore essential to fully appreciate the factors that facilitate or, on the contrary, hinder high-quality longitudinal follow-up.

Eligibility criteria:
inclusion criteria: * patients admitted to icu with glasgow score during initial car ≤ 14 and ct-confirmed head injury * patients admitted to er with glasgow score during initial care ≤ 15 or concussion and ct-confirmed head injury or displaying clinicalsigns such as headaches or vomiting. exclusion criteria: * patients under 18 years of age * single patient, without relative or informal caregiver * non-french-speaking patient * refusal of consent * patient under guardianship

Keywords: cohort pilot study longitudinal follow-up
electrical interactions in heart disease

Conditions: Cardiomyopathy, Dilated

Summary: this study will evaluate the relationship of markers of cardiac activation and their determinants. the hypothesis is that these markers will be interrelated.


Eligibility criteria:
inclusion criteria: * ventricular dysfunction exclusion criteria: * normal ventricular function
elimination of antibiotics during renal replacement therapy and cytosorb adsorptive therapy

Conditions: Critical Illness; Sepsis; Acute Kidney Injury

Summary: cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. the adsorber is frequently used in series with continuous renal replacement therapy. up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. therefore, we want to investigate - whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

patients in this trial are undergoing renal replacement therapy as part of their routine care. thus, this is an observational trial.

Eligibility criteria:
inclusion criteria: * intensive care patients with severe sepsis or septic shock and acute kidney injury requiring continuous renal replacement therapy and cytokine adsorption * age \> 18 y exclusion criteria: * \< 18 y * pregnancy * contraindications against citrate-anticoagulation or continuous renal replacement therapy or cytokine adsorption
iron prehabilitation in endometrial cancer

Conditions: Endometrial Cancer; Perioperative Complication; Prehabilitation

Summary: endometrial cancer patients often have iron deficiency anemia before surgery, which can be effectively treated with oral iron supplementation. anemia and blood transfusions have been previously associated with perioperative infectious diseases. in the present study the investigators will evaluate the impact of perioperative iron supplementation on the incidence of perioperative infections.

prehabilitation has a multimodal conception based on three fundamental pillars: improvement of the patient's physical condition, nutritional optimization and other measures such as smoking cessation and correction of anemia. as in the case of multimodal rehabilitation protocols, the actions of prehabilitation programs have synergistic effects, that is, small changes that, by themselves, do not have clinical significance but when added up, they produce a significant improvement in the postoperative evolution of patients. surgical site infections (ssis) are considered to be the most common nosocomial infections among surgical patients and constitute a heavy and potentially preventable economic burden on health care providers. although the impact of blood transfusion on the risk of ssi remains controversial, several studies have shown that anemia and transfusion predispose to postoperative bacterial infections. in the present study the investigators seek to evaluate the impact of per os iron prehabilitation on perioperative outcomes of endometrial cancer patients, including need for transfusion and infectious morbidity.

Eligibility criteria:
inclusion criteria: women with endometrial cancer enrolled in the surgical list exclusion criteria: women with endometrial cancer requiring immediate surgery due to life-threatening hemorrhage
a study to evaluate the impact of classical music on perceived waiting time and satisfaction in emergency department patients

Conditions: Emergency Room

Summary: the goal of this study is to evaluate whether classical music in the emergency waiting room can diminish perception of waiting times. patients and relatives, after arriving in the er waiting room will either listen to live classical music, recorded classical music, or no music at all.

the study was submitted to the ethics committee as an interventional clinical trial; however, they advised that it does not qualify as a clinical trial. the project does not collect health-related information from patients, according to the definition provided by swiss research law, and therefore does not require any authorization. they qualify it as a quality control initiative. please advise on how we should register it into clinicaltrials.gov, we might need the id for publication purpose. thank you

Eligibility criteria:
inclusion criteria: * er department patients waiting for medical assessment and their relatives * age ≥ 18 years * signed informed consent exclusion criteria: * patients in situations of high severity and that pose an immediate significant threat to life or physiologic function.