Kornimate/medical-research-clean huggingface dataset:
mortality in brain injury at the intensive care unit (travi ii)

Conditions: Traumatic Brain Injuries

Summary: introduction: traumatic brain injuries are a leading cause of disability and mortality in the young population, associated mainly with traffic road accidents and violent wounds. the study aimed to analyze factors related to the mortality in patients with brain injury admitted to the intensive care unit. methodology: between 2019 and 2024, an analytical cross-sectional trial at hospital departamental de villavicencio, colombia was performed. information was selected from the intensive care unit (icu) database. variables of interest and outcomes, such as mortality and icu length of stay, were identified. the comparison was performed with the software prism® for mac ios and wizard® for the predictive model. results: the study will show the factors associated with mortality of brain injury patients admitted to the intensive care unit.

objective: the study aimed to analyze factors related to the mortality in patients with brain injury admitted to the intensive care unit. methodology: between 2019 and 2024, an analytical cross-sectional trial at hospital departamental de villavicencio, colombia, a reference center for the colombian orinoco region with 400 hospital beds and 53 polyvalent icu beds was performed. information was selected from 2,154 admission registers in the intensive care unit (icu) database. data of admissions considered for review were from patients with diagnostic codes of brain injury, brain edema, polytrauma, ventilatory failure, neurogenic shock, and traumatic subarachnoid hemorrhage. all the registries with codes s00-s09 from the 10th revision of the international diseases classification from the world health organization were reviewed. variables of interest and outcomes, such as mortality and icu length of stay, were identified. the comparison was performed with the software prism® for mac ios and wizard® for the predictive model. results: the study will show the factors associated with mortality of brain injury patients admitted to the intensive care unit.

Eligibility criteria:
inclusion criteria: * traumatic brain injury. * admitted to the intensive care unit. exclusion criteria: * remission from another hospital. * decease for causes other than the brain injury.

Keywords: brain injuries traumatic brain injuries brain concussion traffic accidents critical care colombia
assessment of the safety and efficacy of rgn-259 ophthalmic solutions for dry eye syndrome : arise-2

Conditions: Dry Eye Syndrome

Summary: the objective of this study is to compare the safety and efficacy of rgn-259 ophthalmic solutions to placebo for the treatment of the signs and symptoms of dry eye.

dry eye can be caused by many variable factors. some examples include hormonal changes due to aging, or living in an environment of low humidity for long periods of time. dry eye is a complex disease that may result in symptoms like discomfort, visual disturbance, and dryness. patients with dry eye often have damage on the surface of the eye. in previous studies, rgn-259 has been shown to promote healing of the surface of the eye and decrease inflammation. it suggests that rgn-259 has a significant potential to be an important new safe and effective therapeutic in the treatment of dry eye syndrome.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age; * provide written informed consent; * have a subject reported history of dry eye for at least 6 months * have a history of use or desire to use eye drops for dry eye symptoms within 6 months exclusion criteria: * have any clinically significant slit-lamp findings at visit 1 that may include active blepharitis, meibomian gland dysfunction (mgd), lid margin inflammation or active ocular allergies that require therapeutic treatment, and/or in the opinion of the investigator may interfere with study parameters; * be diagnosed with an ongoing ocular infection (bacterial, viral, or fungal), or active ocular inflammation at visit 1; * have ab uncontrolled systemic disease:

Keywords: dry eye syndrome dry eye des
laparoscopic cholecystectomy using airseal in children

Conditions: Gall Stones (&amp; [Calculus - Gall Bladder]); Cholecystitis; Pancreatitis Due to Gallstones; Child, Only

Summary: the goal of this observational study is to compare the use of airseal versus a standard insufflation, in children who underwent laparoscopic cholecystectomy, between january 2021 and december 2022. the main questions it aims to answer are: * amount of analgesics consumed postoperatively * mean digital pain scale data are directly extracted from patients medical files. the investigators will compare the airseal group (a group) to the standard insufflation group (s group) to see if the a group consumes significatively less analgesics and are less painful than the s group.

choosing to enter the a or the s group depends on the surgeon's choice. only the surgeon, the anesthetic and the nurses in the operating room know which type of insufflation has been chosen.

Eligibility criteria:
inclusion criteria: * patients aged under 18 years old * who underwent laparoscopic cholecystectomy * from january 2021 to december 2022 exclusion criteria: * patients older than 18 years old

Keywords: laparoscopy cholecystectomy airseal valveless trocar standard insufflation retrospective study
estrogen treatment in acromegalic women

Conditions: Acromegaly

Summary: oral estrogens may be an effective adjuvant treatment for control of acromegaly in patients with resistance to somatostatin analogs.

this will be a canadian multicenter study with a randomized, double-blind, placebo-controlled design, to assess the efficacy and safety of adjuvant alesse in female acromegalic patients with suboptimal response to sandostatin lar treatment.

Eligibility criteria:
inclusion criteria: * women 18 years and older treated with somatostatin analogs * active acromegaly exclusion criteria: * cardiovascular or cerebrovascular disease * thrombophlebitis or thromboembolism * breast cancer * non-controlled arterial hypertension * smoking * pregnancy or lactation
deliberate ultraviolet light exposure to get a tan by young adult sexual minority males

Conditions: Sun Sensitivity

Summary: the purpose of this study is to: a) identify enablers and barriers to deliberate ultraviolet light exposure by young sexual minority men (smm), and b) quantify the extent of their deliberate ultraviolet light exposure.

aim 1: to develop survey items to assess tanning attitudes and behaviors nine survey items used by the pi in previous deliberate tanning research were adapted with the expert consensus of members of northwestern's institute for sexual and gender minority health and wellbeing. discussions with the pi, research personnel and members of the institute developed the hypothesis that in addition to the previously reported appearance motivations young smm may be engaging in tanning (indoors or outdoors) as a social activity. a tenth survey item was developed to assess deliberate tanning as a social activity. aim 2: analyze the tanning attitudes and behavior data acquired in an online survey of young adult sexual minority males, who regularly participate in the radar study. radar is a longitudinal study with cohorts from the greater chicago region recruited between 2008 and 2015. the 10 survey items about tanning attitudes and behaviors were added to the online survey that examines smms' behavior in the prior 6 months. this is a secondary analysis of registry data acquired by the radar study.

Eligibility criteria:
inclusion criteria: * young adult smm (age 18-39) * able to read english * have internet access * willing to complete the online survey exclusion criteria: * none
weight-adjusted vs fixed low doses of low molecular weight heparin for venous thromboembolism prevention in covid-19

Conditions: COVID; Thrombosis; Pulmonary Embolism; Deep Vein Thrombosis

Summary: worldwide observational studies indicate a significant prothrombogenic effect associated with sars-cov-2 infection with a high incidence of venous thromboembolism (vte), notably life-threatening pulmonary embolism. according to recommendations for acute medical illnesses, all covid-19 hospitalized patients should be given vte prophylaxis such as a low molecular weight heparin (lmwh). a standard prophylactic dose (eg. enoxaparin 4000iu once daily) could be insufficient in obese patients and vte has been reported in patients treated with a standard prophylactic dose. in covid-19 patients, guidelines from several international societies confirm the existence of an hypercoagulability and the importance of thromboprophylaxis but the "optimal dose is unknown" and comparative studies are needed. in view of these elements, carrying out a trial comparing various therapeutic strategies for the prevention of vte in hospitalized patients with covid-19 constitutes a health emergency. thus, we hypothesize that an increased prophylactic dose of weight-adjusted lmwh would be greater than a lower prophylactic dose of lmwh to reduce the risk of life-threatening vte in hospitalized patients. the benefit-risk balance of this increase dose will be carefully evaluated because of bleeding complications favored by possible renal / hepatic dysfunctions, drug interactions or invasive procedures in covid-19 patients. this multicenter randomized (1:1) open-label controlled trial will randomize hospitalized adults with covid-19 infection to weight-adjusted prophylactic dose vs. lower prophylactic dose of lmwh.


Eligibility criteria:
inclusion criteria: * adult patient hospitalized for a probable/confirmed covid-19 infection (confirmed by serology/polymerase chain reaction or by radiologic signs of covid-19 pneumonia in the setting of clinical and laboratory abnormalities suggestive of a sars-cov-2 infection) * signed informed consent * patient affiliated to the social security exclusion criteria: * renal insufficiency with a gfr\<15 ml/min/1.73m² * acute kidney injury kdigo3 * prophylactic dose of low molecular weight heparin for more than 3 days * curative dose of low molecular weight heparin for more than 1 day * recurrent catheter/hemodialysis access thromboses * ecmo required in the next 24h * contraindication to low molecular weight heparin * high bleeding risk (e.g. uncontrolled severe systemic hypertension, recent major bleeding, disseminated intravascular coagulopathy, thrombocytopenia \< 75g/l) * history of heparin-induced thrombocytopenia * contraindication to blood-derived products * impossibility to perform a doppler ultrasound of the lower limbs (e.g. above the knee amputation, severe burn injuries) * expected death in the next 48h * vulnerable subjects according to articles l. 1121-5, l. 1121-7 et l1121-8 of french public health code

Keywords: covid thrombosis venous thromboembolism pulmonary embolism deep vein thrombosis low molecular weight heparin
comparison of entecavir to adefovir in chronic hepatitis b virus (hbv) patients with hepatic decompensation

Conditions: Hepatitis B

Summary: this is a phase iiib comparative study of entecavir 1.0 mg once daily (qd) vs. adefovir 10 mg qd in patients who have chronic hepatitis b infection and hepatic decompensation. the patients are treated for 96 weeks after the last subject is randomized.


Eligibility criteria:
inclusion * child-pugh (cp) score \>= 7 * hepatitis b virus (hbv) viremia exclusion * alanine aminotransferase (alt) \> 15 x upper limit of normal (uln) * human immunodeficiency virus (hiv)/hepatitis c virus (hcv)/hepatitis d virus (hdv) coinfection

Keywords: hepatic decompensation
feasibility of cardiovascular health intervention within evidence-based home visiting

Conditions: Diet, Healthy; Inactivity, Physical; Obesity

Summary: the purpose of this pilot study is to examine the feasibility and acceptability of brief lifestyle intervention modules designed to promote healthy eating, activity, and weight control for pregnant and postpartum clients receiving care as part of evidence-based home visiting.

the purpose of this pilot study is to examine the feasibility and acceptability of brief lifestyle intervention modules designed to promote healthy eating, activity, and weight control behaviors for pregnant and postpartum clients receiving care as part of evidence-based home visiting. a 6 week, pre-post test of evidence-based home visiting (usual care) plus three lifestyle intervention modules (eating, activity, tracking) will be conducted at two sites (california and rhode island). three, 10 minute intervention modules will target healthy eating, activity, and self-monitoring of weight and diet. pregnant and postpartum clients (n =20) in home visiting programs will be recruited over 2 months and evaluated at baseline and after 6 weeks. home visitors will participate in one training session and deliver the intervention content during three visits over 6 weeks. quantitative data from will inform feasibility of lifestyle intervention within evidence-based home visiting. findings will inform the cardiovascular health intervention and study protocol for a full scale trial.

Eligibility criteria:
inclusion criteria: * self-reported current participation in a home visiting program * self-reported currently pregnant or postpartum less than or equal to 6 weeks * english or spanish speaking exclusion criteria (based on self report): * age less than 18 years * lower than 5th grade reading level

Keywords: home visiting obesity pregnancy postpartum cardiovascular health
sensory re-training following facial surgery for correction of facial skeletal disharmony

Conditions: Mandibular Advancement

Summary: the purpose of this study is to determine whether facial exercises in conjunction with opening exercises routinely provided after facial surgery to correct a facial skeletal disharmony will shorten the time until a patient receives no unpleasant or negative facial sensation.

abnormal facial sensation has a negative impact on patients' oral behaviors and may adversely affect a patient's quality of life if the altered sensation persists. many patients with abnormal sensations retain some sensory function and do not develop chronic pain, and for those individuals there are currently no evidence-based noninvasive therapies. the goal of this project is to evaluate sensory re-training, a rehabilitative therapy that offers significant potential for patients who experience impaired sensory function regardless of the cause. this behavioral therapy approach has been used with substantial clinical success with hand injury patients since the 1970s. re-training appears to enhance central reorganization of impulses from an injured sensory nerve to the cerebral cortex so that the altered sensory signals can be interpreted and translated into functionally meaningful motor functions. sensory re-training will be compared to a placebo jaw-opening exercise in a single blind, randomized two-arm parallel group stratified block clinical trial, using orthognathic surgery patients as subjects. orthognathic surgery patients offer an uncompromised model for the evaluation of new rehabilitative therapies. these healthy individuals, treated to correct dentofacial deformity, present for surgery with no neurosensory impairment, but yet routinely experience substantial alterations in facial sensation following the surgical procedure. the effects of sensory re-training will be evaluated using three types of outcomes: patient-centered measures to assess the magnitude of the negative effect of altered sensation after surgery and the recovery time needed to reach little or no negative effect; neurosensory behavior measures to assess the patient's ability to learn alternate cues for touch perception and discrimination; and a conventional neurosensory contact threshold measure to assess the actual deficit. our primary focus will be on the patient's perception of the negative impact of altered sensation on daily life.

Eligibility criteria:
inclusion criteria: * developmental dentofacial disharmony * receives mandibular advancement by mandibular osteotomy with or without a maxillary procedure. exclusion criteria: * congenital anomaly or acute trauma affecting the face. * previous facial surgery * pregnant at baseline * inability to follow written english instructions * unwilling to sign informed consent. * no altered sensation at one week post-surgery * altered sensation at baseline reported as numbness or unusual feeling. * medical condition associated with systemic neuropathy.

Keywords: outcome and process assessment (health care) behavior control sensation randomized controlled trials adolescent adult
improve acute reperfusion treatment quality for stroke in china, improve: stroke care in china

Conditions: Ischemic Stroke

Summary: in order to bridge the great gaps, chinese stroke association (csa) and american heart association (aha) sought to develop, conduct, and assess a multifaceted quality improvement intervention to increase the adherent rate of iv tpa and et and improve 3-month clinical outcomes for these patients through our cluster-randomized stepped-wedge improve: stroke in china trial.


Eligibility criteria:
inclusion criteria: hospitals： 1. voluntary. 2. hospitals from csca. 3. secondary or tertiary public hospitals with an emergency department and neurologic wards that receive patients with ais. 4. have a 24\*7 on-call stroke team. 5. have the capacity of iv rt-pa thrombolytic therapy or/and endovascular treatment. 6. implement at least 10 patients' rt-pa or/and endovascular treatment during the last year. 7. admit at least 5 patients of acute ischemic stroke within 24 hours after onset each month. 8. have full desire to improve the procedure of treatment of acute ischemic stroke. 9. have good cooperation among neurology department, emergency department, interventional department, neurosurgery department, laboratory and radiology department. patients： patients who are ≥18 years old were eligible for inclusion if they presented with acute ischemic stroke diagnosed by ct and/or mri and arrived at hospital within 6 hours after symptom onset. exclusion criteria: hospitals： 1. hospitals that can not comply with the protocol and finish the research. 2. grade-one hospitals and non cerebral vascular disease specialized hospitals. 3. hospitals involved in other stroke care quality improvement projects or relevant clinical trials. patients： 1）patients refuse to participate in this study

Keywords: acute ischemic stroke iv-tpa endovascular treatment intervention
evaluation of two surgical scopinaro techniques in the treatment of obesity

Conditions: Obesity

Summary: the purpose of this study is to show that the modified technique scopinaro surgery allows a better control or reduction of complications often found in nutritional pancreatic and biliary derivations, starting from the assumption of a modified technique is as effective as scopinaro classical technique for reducing overweight and control of comorbidities in obese patients with grade ii and iii.

28 participants will be recruited and will be divided into 2 groups of 14 subjects each one. one group will receive the classic scopinaro surgery and the other, modified scopinaro surgery. in scopinaro surgery modified will be held with laparotomy and median opening in layers. it will also be performed at the manufacturing drifting pancreatic and biliary derivations, roux-en-y, dividing the small stomach.a communication portal to be implemented and calibrated through a nasogastric tube of 10mm where a retaining ring is placed horizontal gastroplasty, in order to avoid an expansion of this communication. in the classical scopinaro surgery will be done the same procedures of scopinaro modified surgery , but the gastroplasty will be replaced by horizontal gastrectomy.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) \> 35; * body mass index greater than or equal to 40; * be indicated for bariatric surgery after other attempts at treatment; * if bmi \> 35 and \<40, must submit at least one of comorbidities below: type ii diabetes, dyslipidemia, hypertension, joint arthropathy in average or great, sleep apnea, hypothyroidism. exclusion criteria: * pregnant or breastfeeding * had undergone bariatric surgery before. * diagnostic of psychiatric disorders, according to the evaluation of especialist. * be user of illegal drugs or alcohol abuse. * be severe disease carrier, according to an evaluation specialist. * have severe lung disease or liver cirrhosis, according to the evaluation of especialist. * being active virus carrier - hiv. * has any condition that prevents surgery
a study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of hs-10561 capsule in healthy chinese adults and patients with chronic spontaneous urticaria.

Conditions: Chronic Spontaneous Urticaria

Summary: this is a randomized, double-blind, placebo-controlled phase 1/2 clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of hs-10561 capsule in healthy chinese adults and patients with chronic spontaneous urticaria.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment is performed.(sd) * healthy adults aged 18-45 years (inclusive) at the time of signing the informed consent form;(sd) * male participants weighing ≥ 50 kg and female participants weighing ≥ 40 kg; body mass index (weight/square of height (kg/m2)) within the range of 18-30 kg/m2 (inclusive);(sd) * female participants and male participants (including their female partners) agree to use highly effective methods of contraception from the date of signing the informed consent form until 30 days after the last dose;(sd) * without history of severe respiratory, gastrointestinal (such as inflammatory bowel disease, crohn's disease, chronic diarrhea, etc.), neurological, circulatory, urinary, endocrine, musculoskeletal, immune system disorders, or a history of tumors prior to screening.(sd) * written informed consent must be obtained before any assessment is performed.(md and phase 2) * healthy adults aged 18-65 years (inclusive) at the time of signing the informed consent form;(md and phase 2) * have been diagnosed with chronic spontaneous urticaria for ≥6 months at the time of screening;(md and phase 2) * female participants and male participants (including their female partners) agree to use highly effective methods of contraception from the date of signing the informed consent form until 30 days after the last dose.(md and phase 2) exclusion criteria: * have clinically significant abnormalities in vital signs, physical examination, laboratory tests, chest x-ray/ct, or abdominal ultrasound during the screening period, which, as assessed by the investigator, may increase the participants' risk or affect the scientific validity of the study;(sd) * females with a positive blood pregnancy test, breastfeeding females, or participants planning to become pregnant during the study period;(sd) * any physiological or psychological condition or disease, as determined by the investigator, that could increase the risk, affect the participants' compliance, or impact the participants' ability to complete the study.(sd) * chronic urticaria with a clear primary or sole trigger (chronic inducible urticaria);(md and phase 2) * clearly defined predominant or sole trigger of their chronic urticaria (chronic inducible urticaria);(md and phase 2) * other diseases with symptoms of urticaria or angioedema;(md and phase 2) * other skin disease associated with chronic itching that might influence in the investigators opinion the study evaluations and results;(md and phase 2) * pregnant or nursing (lactating) women.(md and phase 2)

Keywords: chronic spontaneous urticaria