Kornimate/medical-research-clean huggingface dataset:
response of nafld patients to mediterranean diet

Conditions: NAFLD; Steatosis of Liver

Summary: the effects of mediterranean diet (meddiet) on clinical, biochemical and inflammatory profile in nafld patients with simple steatosis. potential associations of single nucleotide polymorphisms to diet composition and patients' profile were also investigated.

diet is a modifiable key factor targeted in prevention and management of non-alcoholic fatty liver disease (nafld). the aim of the study is to investigate the effect of mediterranean diet (meddiet) on clinical, biochemical and inflammatory profile in nafld patients with simple steatosis. potential associations of single nucleotide polymorphisms to diet composition and patients' profile are investigated. in this non-randomised, open-label study, 44 untreated nafld patients with non significant fibrosis receive nutritional counsel to increase adherence to meddiet. adherence to meddiet is estimated with meddietscore. furthermore, genotyping of stat3 rs2293152 and gckr rs1260326 single nucleotide polymorphisms takes place.

Eligibility criteria:
inclusion criteria: * men and women \>18y of age, no change in body weight (bw) for the last 6 months prior to the trial and body mass index (bmi) \>25 kg/m2. exclusion criteria: * the presence of chronic viral hepatitis, the presence of congenital or acquired liver disease, the history of prior exposure to hepatotoxic drugs, the evidence of hepatic cirrhosis, ultrasonography values less than 1hz, bariatric surgery, daily consumption of ethanol more than 20g for women and more than 30g for men for over 6 months during the last 5 years, any medication effective on fatty liver disease introduced \ 65 years, pregnant or lactating women, subjects supplemented with omega-3 polyunsaturated fatty acids, probiotics/synbiotics, antioxidant vitamins and/or phytochemicals, any planned, structured and repetitive physical activity. patients with any medication change during the trial were excluded from analysis.

Keywords: nafld no fibrosis mediterranean diet stat3 gckr visfatin oxidized ldl fasting glucose inflammation
loratadine for improvement of bone pain in patients with chronic granulocyte-colony stimulating factor (g-csf) use

Conditions: Bone Pain

Summary: g-csf causes a release of histamine that may be a cause of chronic bone pain. loratadine targets histamine, and so may be effective in reducing bone pain.the researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic g-csf use.


Eligibility criteria:
inclusion criteria: * diagnosis of neutropenia * granulocyte-colony stimulating factor (g-csf) use for at least 3 months at least 4 times per month * mean bone pain of at least a 2/10 as assessed by questions 3-6 of the brief pain inventory (bpi) exclusion criteria: * other sources of chronic pain * previously tried loratadine for 7 consecutive days or more for bone pain * allergy to loratadine * chronic daily usage of antihistamine without an acceptable alternative non-antihistamine medication

Keywords: granulocyte-colony stimulating factor
the effects of regular mountain hiking on hopelessness in chronically suicidal patients

Conditions: Suicide; Hopelessness

Summary: suicide is a major public health issue with estimated 1 million deaths worldwide within the last year. physical activity and nature recreation might be protective factors against suicidal behaviour, suicidal ideation and contributing factors like depression and hopelessness. in this randomized controlled cross-over intervention study the investigators aim to investigate the physical and psychological effects of a 9 weeks hiking program in chronically suicidal patients. the investigators aim to enroll 24 patients suffering from chronic suicidality, defined as at least one attempted suicide and a hopelessness greater than 26 in beck's hopelessness scale summary score. at baseline patients will undergo pre-tests including questionnaires to assess suicide ideation, hopelessness, depression, anxiety, quality of life and health-related physical activity, physiological investigations to assess exercise capacity and blood investigations. randomly assigned 12 patients start with the 9 weeks supervised mountain hiking program followed by a 9-week-period without supervised exercise program. the other 12 patients start with 9 weeks without supervised exercise program followed by a 9-week-period of supervised mountain hiking program. the mountain hiking program includes 2 training sessions per week with a duration of 3 hours per session. the hiking intervention will be performed within 70-85% of heart rate reserve and gymnastics for body and nature perception, mobilisation and stretching will enrich the training program. further investigations including questionnaire-assessments, assessment of exercise capacity and blood investigations will be scheduled 9 and 18 weeks after the study start. in addition a daily assessment of several suicide risk-factors based on a web-based questionnaire will be done over the full study period. within this mountain hiking program the investigators hope to reduce hopelessness in chronically suicidal patients.


Eligibility criteria:
inclusion criteria: chronically suicidal defined as: * at least one attempted suicide * bhs summary scale \> 26 exclusion criteria: * coronary heart disease defined by angina pectoris or relevant st-changes during exercise or myocardial infarction in the last 6 months * not oriented in time and space * demented * acute psychotic * cognitively impaired * insufficient german language skills

Keywords: physical activity mountain hiking exercise training program hopelessness chronic suicidality depression suicide attempt suicide
investigation of two swallowing therapy models during radiation therapy for head and neck cancer

Conditions: Head Neck Cancer

Summary: vibrent health is partnering with stanford cancer center to conduct a randomized control trial (rct) using mobile health technology to enhance adherence and improve swallowing outcomes in patients undergoing radiation therapy for head and neck cancer.

head and neck cancer (hnc) is the 6th most common type of cancer in the world and has recently seen a dramatic rise in the united states due to a rise in the incidence of oropharyngeal cancers related to the human papillomavirus (hpv) . the majority of patients diagnosed with hnc receive radiation therapy at some point in their treatment, either in the definitive or post-operative setting. dysphagia is a common consequence of treatment for hnc, experienced by approximately 50% of patients treated with radiation therapy. post-treatment dysphagia has been associated with increased risk of morbidity/mortality as well as well-recognized deterioration of quality of life. performance of swallowing exercises during radiation significantly reduces dysphagia risk; however, patient adherence to swallowing exercises during radiation treatment is limited. thus, poor adherence stands as a major obstacle to achieving the best swallowing outcomes. in response to this, a mobile health application was developed to directly address barriers cited by patients as reasons for non-adherence. the objective is to conduct a randomized controlled trial to test the impact of the mobile application on adherence to prophylactic swallowing therapy during radiation for hnc.

Eligibility criteria:
inclusion criteria: * study subjects ≥ 18 years of age. * fluent english speaking subjects. * study subjects capable of providing informed consent. * patients with newly diagnosed non-metastatic head and neck cancer of the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx that require bilateral neck radiation. individuals with unknown primary head and neck cancer with nodal disease necessitating bilateral radiation will also be included. * study subjects with a previously untreated head and neck cancer diagnosis requiring a definitive course of radiotherapy requiring a prescribed dose of 60gy or greater. * study subjects who have either an android or apple ios-based smartphone or tablet compatible with the vibrent application. * study subjects who have access to a sufficient monthly data plan (approximately 200 mb/month), or internet connection. exclusion criteria: * non-english speaking, or incapable of providing informed consent. * lack of smartphone, tablet, or internet connection. * inability to use the vibrent application. * patients being treated for head and neck cancer who do not receive some form of primary, adjuvant, or neo-adjuvant radiation therapy will not be considered for the study. * patients with recurrent disease. * pregnant women. * individuals under the age of 18. * individuals with contraindications to radiation therapy.
single embryo transfer of euploid embryo

Conditions: Infertility; Aneuploidy

Summary: the purpose of the current study is to evaluate the effect of preimplantation genetic screening (pgs) by next generation sequencing (ngs) compared to standard morphological assessment of embryos on pregnancy rates through a randomized controlled trial (rct). all embryos will be vitrified and a single embryo transfer (set) will be performed with either screened or unscreened embryos depending on randomization.


Eligibility criteria:
inclusion criteria: * patient undergoing ivf * at least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development exclusion criteria: * history of more than two prior implantation failure following ivf * history of more than one miscarriage of viable pregnancy * one or both partners known to be carrier(s) of a chromosomal abnormality * known genetic carrier couple and/or one or both partners carrier of a known autosomal dominant disorder * any other non-study related preimplantation genetic testing * use of donor oocytes * use of gestational carrier (surrogate or donor egg recipient). * severe oligospermia (\<1,000,000 sperm/ml); surgical sperm retrieval for reasons other than post-vasectomy and cavd * low ovarian reserve with (fsh) \>10 iu/l on day 2-4 of a prior menstrual cycle and/or (amh) \<7 pmol/l (or \<1 ng/ml) * gender selection cycles * concurrent participation in another clinical trial

Keywords: preimplantation genetic screening blastocyst vitrification in vitro fertilization non-invasive prenatal testing next generation sequencing
differences in pain processing between men and women

Conditions: Central Sensitisation

Summary: many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women. yet, the underlying mechanisms causing these differences are poorly understood. central sensitization (cs) is considered one important mechanism in pain patients which differs between female and male patients. the central hypothesis is that already in the healthy population cs processes are more pronounced in women than in men.


Eligibility criteria:
inclusion criteria: * good general health * able to give informed consent exclusion criteria: * pain complaints for more than two consecutive days over the past three months * any major medical or psychiatric condition (e.g. heart disease, major depressive disorder) * any chronic pain condition * inability to follow study instructions * consumption of stimulants, drugs, or analgesics within the past 24 hours * scar tissue or generally reduced sensitivity in the designated testing site areas

Keywords: central sensitisation central sensitization nociception withdrawal reflex heat pain secondary hyperalgesia
intermittent fasting using a fasting-mimicking diet to improve prostate cancer control and metabolic outcomes

Conditions: Prostate Adenocarcinoma

Summary: this is a phase 2, randomized two-armed, multi-site study of 138 patients with metastatic castrate sensitive prostate adenocarcinoma. patients will be randomized 1:1 to receive the fasting mimicking diet, or usual diet. all patients will receive standard of care treatment for their prostate cancer. the fasting mimicking diet will be consumed for 5 days per month for a total of 6 months and will be monitored by trained research dietitians. this study aims to examine the effects of a fasting mimicking diet (5 days per month eating l-nutra products only for 6 months) vs. usual diet on response to cancer treatment of metastatic castrate sensitive prostate adenocarcinoma.


Eligibility criteria:
inclusion criteria: * metastatic castrate sensitive prostate adenocarcinoma (adenocarcinoma prostate histologically confirmed by biopsy and metastatic disease confirmed biopsy, or mri scan) * men receiving or planning to start first-line intensified adt (within 30 days of registration) with abiraterone, apalutamide, enzalutamide, or darolutamide with or without current or prior chemotherapy * reads, writes, and understands english or spanish and has telephone access for remote contact with the study dietitian. * written informed consent obtained from subject and ability for subject to comply with the requirements of the study. exclusion criteria: * allergies to any ingredients listed on the xentigen ingredient list * men with diabetes who are not on stable doses of antihyperglycemic medication for at least 6 months and without physician consent that they may safely hold antihyperglycemic medication during the 5 days of fmd * regularly practicing a fasting diet that in the opinion of the study physician would impact study participation * significant co-morbidities (i.e., cardiac, pulmonary, liver disease, ongoing alcohol/drug abuse) that in the opinion of the study physician would preclude enrollment in this study. * body mass index (bmi) \<20kg/m2 * men actively trying to lose weight or on weight loss medications (including but not limited to contrave, saxenda, xenical) or planning to receive weight loss surgery in the next six months * self-reported weight loss ≥ 10% in the last 6 months

Keywords: fasting
five days quadruple and clarithromycin containing triple therapy as treatment for helicobacter pylori eradication

Conditions: Helicobacter Pylori Infection

Summary: the aim of this randomized trial is to compare the efficacy and tolerability of h. pylori eradication with a 5-day quadruple therapy versus a clarithromycin-containing triple therapy.

eligible patients with h pylori infection were randomized to receive either five-day quad (esomeprazole 20mg b.d., bismuth subcitrate 120mg q.i.d., tetracycline 250mg q.i.d. and metronidazole 250mg q.i.d.) or eac (esomeprazole 20mg b.d., amoxicillin 1g b.d. and clarithromycin 500mg b.d.). h. pylori status was rechecked by 13c urea breath test 8 weeks after treatment. patients who failed their respective therapy were invited to undergo h. pylori susceptibility testing and crossover to receive the alternative regimen for the same duration.

Eligibility criteria:
inclusion criteria: * patients with h. pylori infection * did not receive h. pylori eradication therapy before exclusion criteria: * patients who have received previous h. pylori eradication therapy * co-morbidity of liver cirrhosis * co-morbidity of renal failure * co-morbidity of alcoholism * co-morbidity of malignancy * received antibiotics, bismuth preparations, proton pump inhibitors or probiotic in the preceding three months * patients with known allergy to the medications used * patients with a history of previous gastrointestinal diseases or gastric surgery * pregnancy
mechanisms and functional outcomes of exercise progression models in the elderly

Conditions: Elderly; Sedentary

Summary: the aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and orthopedically well tolerated by the elderly. findings from study laboratories have suggested that a regional specific training stimulus (rsts) results in rapid improvements in both vascular and muscular function. rsts is a novel combination of resistance training and aerobic training applied simultaneously, and in a serial manner, to specific regions of the body. it involves high-intensity and frequency muscle contractions, generating a targeted exercise stimulus, without producing excessive cardiovascular or orthopedic stress. the hypothesis is that initiating training with rsts at multiple, strategically selected peripheral sites, in a serial manner will elicit local vascular and muscular changes, thereby preparing individuals at elevated risk of losing independence, to respond and progress more favorably to whole-body exercise.


Eligibility criteria:
inclusion criteria: * \>70 yrs of age * sedentary (exercising \<1 day/wk) * non-smokers * able to ambulate without use of an assistive device * able to walk between 200-450m on a 6-minute walk test exclusion criteria: * oxygen dependent * recent medications changes (within 3 months) * current smokers * fixed-rate pacemakers * uncontrolled hypertension or type ii diabetes * positive ecg changes or angina during cpx testing * unable to complete a maximal cpx to volitional fatigue * aha class d, or nyha class iii or iv heart failure

Keywords: aging functional capacity exercise independence peripheral adaptations vascular
safety and effectiveness of covid-19 vaccine in kidney transplant recipients

Conditions: COVID-19 Vaccination; Renal Transplant

Summary: the current study is a noninterventional prospective study examining the efficacy of additional dosage of the coronavirus disease 2019 (covid-19) vaccine in kidney transplant recipients (ktrs).

in this clinical, prospective, non-interventional study to assess the effectiveness of an additional dose of covid-19 vaccination, we evaluated the seroconversion rate of ktrs after the booster shot. consecutive individuals who have completed standard two-doses of covid-19 vaccination were enrolled. following consent, demographic and clinical data were collected from participants, including patient/ transplant characteristics and information regarding previous covid-19 vaccination. 1 study visit and sample collection patients were invited to return for up to 2 follow-up visits for sample collection. whole blood samples were collected two weeks to 1 day before the booster vaccination and 4 weeks after. during the visit for the second blood sample, a survey was conducted to assess booster-related adverse events. 2. anti-sars-cov-2 antibody assay igg antibodies against the receptor-binding domain (rbd) of the s1 subunit of the spike protein of severe acute respiratory syndrome coronavirus 2(sars-cov-2) were quantified with sars-cov-2 igg ii quant assay (abbott). additionally, neutralizing antibody was assessed using anti-sars-cov-2 genscript cpass sars-cov-2 neutralization antibody detection kit. the cpass detection kit utilizes the horseradish peroxidase (hrp) conjugated recombinant sars-cov-2 rbd protein and the human angiotensin-converting enzyme 2 (ace2) receptor protein. it detects neutralizing antibodies capable of blocking protein interaction between hrp-rbd and ace2. the assay was performed according to the manufacturer's instructions.

Eligibility criteria:
inclusion criteria: 1. patients who received kidney-only transplantation or multi-organ transplantation including kidney before december 31, 2020 2. patients ≥ 12 years old 3. patients fully vaccinated with two standard doses of covid-19 vaccination with the vector vaccine (azd1222 of astrazeneca) or the mrna vaccines (bnt162b2 of pfizer-biontech or mrna-1273 of moderna) including homologous and heterologous regimen. 4. patients with plans of getting an additional dose of covid-19 vaccine (i.e., booster shot) 5. patients providing informed consent and willing to comply with the study protocol, including two blood tests and a survey. exclusion criteria: 1. patients with a previous history of sars-cov-2 infection 2. who had b-cell depleting therapy (e.g., rituximab, bortezomib) or t-cell depleting therapy (anti-thymocyte globulin) within six months 3. patients who restarted dialysis due to graft failure
working memory training in patients with mild cognitive impairment

Conditions: Mild Cognitive Impairment (MCI)

Summary: the purpose of this study is to test whether a special memory training program, called cogmed, can help people with early memory problems. the investigators want to see if this training improves memory and also helps reduce stress. the investigators also want to see if cogmed results in changes to a blood biomarker called p-tau 217, which possibly indicate alzheimer's disease (ad).

the goal of this study is to conduct a pilot clinical trial aimed at comparing the effects of cogmed intervention plus treatment as usual (tau) versus tau alone in patients with mild cognitive impairment (mci). based on our preliminary data from brain health program, the primary hypothesis is that the cogmed intervention may improve the cogmed measures and possibly working memory. this may improve sense of self-efficacy and lead to a decrease in perceived stress, thereby demonstrating possible transfer of cognitive benefits to biobehavioral construct of perceived stress. additionally, the study aims to demonstrate the feasibility of collecting p-tau 217, a blood based alzheimer's disease biomarker, from mci patients. though no significant changes in ptau 217 are expected due to the short duration of the study, the goal is to successfully recruit 10 mci patients (5 in the intervention group and 5 in the control group) who are willing to undergo blood draws for p-tau 217 level determination.

Eligibility criteria:
inclusion criteria: 1. male or female outpatients ages ≥ 50 years; 2. meet mayo clinic criteria for mci. (patients with mild cognitive impairment) 3. access to the internet through computer 4. a proficiency in speaking and reading english or having a family member who is proficient in reading and speaking english and is willing to serve as a translator. 5. vision and hearing must be sufficient to comply with study procedures. exclusion criteria: 1. mini mental state exam (mmse) score less than 19 or patients diagnosed with moderate or severe dementia by a clinician. 2. in the opinion of the investigator, participation would not be in the best interest of the subject.

Keywords: cogmed mild cognitive impairment cogmed intervention targeting working memory cogmed intervention vs treatment as usual working memory training alzheimer&#39;s disease