Kornimate/medical-research-clean huggingface dataset:
outcome of old patient with articular with articular implant infection

Conditions: Complications; Implant, Orthopedic, Infection or Inflammation

Summary: articular implant infection (aii) is itself a complicated diagnosis and a challenging condition to treat. in elderly patients, the application of existing recommendations is impeded by multiple frailties for a better knowledge of the long-term consequences of aii in elderly patient, the investigators conduct a prospective, multicentric study, whitch aim this is to better evaluate the burden of aii on elderly patients, in terms of quality of life. secondly, the investigators would like to identify the factors that influence the prognosis, in order to guide further prospective research.

articular implant infection (aii) is itself a complicated diagnosis (diagnosis confirmation, pathogen identification, with appropriate samples) and a challenging condition to treat (long antibiotic exposure, repeated surgery, complex implant change). this condition requires a good cooperation between surgeon and infectious disease specialist, with a comprehension of each one's constraint. in elderly patients, the application of existing recommendations is impeded by multiple frailties (malnutrition, loss of autonomy, polypathology) which make each decision crucial. indeed, from the choice of surgery to antibiotics management, all medical decision can induce more adverse events than in younger patients. for a better knowledge of the long-term consequences of aii in elderly patient, the investigators conduct a prospective, multicentric study, based on the evaluation of the eq-5d-5l score during one year after aai diagnosis in patients older than 75. the investigators evaluate this score and compare different groups of patients, according to age, nutrition status, charlson comorbidity index, hospital stay length, and loss of autonomy, among others. the aim of this study is to better evaluate the burden of aii on elderly patients, in terms of quality of life. secondly, the investigators would like to identify the factors that influence the prognosis, in order to guide further prospective research.

Eligibility criteria:
inclusion criteria: * hospitalized in infectious diseases, surgery, post-emergency unit, or geriatrics, * diagnosed with a hip or knee prosthesis infection in the previous month according to the spilf criteria (2009)(1). exclusion criteria: * above criteria not met, * patient refusal, * mild cognitive impairment or more significant.

Keywords: articular implant infection
effects of parental holding on pain response in young children during cystometry

Conditions: Vesico-Ureteral Reflux; Filum Terminale Lipoma

Summary: cystometry is essential for diagnosis and treatment plans by identifying the causes of lower urinary tract symptoms and objectively evaluating bladder functions in diseases such as neurogenic bladder, voiding dysfunction, and vesicoureteral reflux. children may experience pain during this invasive procedure of inserting the urethra catheter. furthermore, infants aged ≥ 6 months may feel pain from an unfamiliar and unnatural environment as they experience stranger anxiety. this experience can have a negative physical and emotional impact on children, and uncooperative behavioral reactions caused by pain can hinder the procedure. in this regard, parental holding is known as effective non-pharmacological procedural pain management in children. although the international children's continence society has advised performing cystometry while holding the infant as an effective non-pharmacological pain management method, there is insufficient evidence to support this. so, this study aimed to analyze the effect of parental holding on reducing pain in children during cystometry.

this is an experimental study in a randomized controlled pre-posttest design. during cystometry, participants in the experimental group are placed on the parents' laps and held in the parents' arms. participants in the control group are laid down on the examination table. the behavioral (flacc scale) and physiological (oxygen saturation and heart rate) pain responses are measured at three time points (immediately, 3 min, and 10 min after urethral catheter insertion).

Eligibility criteria:
inclusion criteria: 1. the children aged 6-18 months. 2. the children who undergo cystometry for the first time. 3. the children who undergo cystometry with their parents. exclusion criteria: 1. the child who is premature or has a low birth weight 2. the primary caregiver is not the participant's parent 3. the child who has unstable vital signs 4. the child is expected to have neurological or sensory impairments (e.g., spinal cord inflammation, spina bifida).

Keywords: cystometry children parental holding procedural pain pain response pain management
handheld dynamometer during awake craniotomy pilot

Conditions: Brain Lesion; Brain Tumor Adult; Brain Tumor

Summary: the primary purpose of this study is to assess the feasibility, safety and reliability of the use of handheld dynamometry in evaluating intraoperative motor function for patients undergoing awake craniotomy for the resection of brain lesions located within or adjacent to the motor cortex.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years old. * primary or recurrent brain tumors * single brain lesion * lesion within or adjacent to the motor cortex- lesion located within the primary or supplementary motor area (verified by preoperative fmri and dti). exclusion criteria: * patients \< 18 years old. * major comorbidities (congestive heart failure, severe chronic obstructive pulmonary disease, morbid obesity, obstructive sleep apnea). * patients with cognitive, intellectual or psychiatric impairment that could affect the capacity of following instructions evaluated during preoperative neuropsychological testing.

Keywords: awake craniotomy dynamometer motor brain mapping
a prospective trial on nerve sparing techniques performed in radical prostatectomy

Conditions: Prostate Cancer; Quality of Life

Summary: the investigators propose a prospective study to assess recovery of urinary and sexual function by nerve sparing techniques after radical prostatectomy.

subjects will be randomized in a 1:1 ratio to retzius nerve sparing versus non-retzius nerve sparing to compare cancer outcomes and urinary/sexual outcomes following radical prostatectomy. using the retzius technique, the surgeon will remove the prostate in a way that preserves a portion of the nerves and tissue structures that are typically removed during the conventional technique. the investigators will assess recovery of urinary and sexual function of patients through questionnaires at 1 week, 1 month, 6 months, 12 months, and 24 months after surgery.

Eligibility criteria:
inclusion criteria: * clinically localized prostate cancer * able to read and speak english or spanish * no previous history of head injury, dementia or psychiatric illness * no other concurrent cancer * estimated life expectancy of 10 years or more * biopsy proven prostate cancer exclusion criteria: * evidence of metastases * prostate specific antigen (psa) greater than 30 ng/ml * previous major pelvic surgery * diagnosis of another malignancy within the past 5 years, with the exception of non-melanoma skin cancer

Keywords: prostate cancer radical prostatectomy robot-assisted radical prostatectomy prostatectomy nerve sparing retzius quality of life urinary incontinence sexual function
study in predicting outcome of patients undergoing radiation therapy for prostate cancer

Conditions: Prostate Cancer

Summary: rationale: proteins found in blood and urine samples may help predict outcome and allow doctors to plan more effective treatment. purpose: diagnostic trial to study blood and urine proteins in predicting treatment outcome in patients who are undergoing radiation therapy for prostate cancer.

objectives: * correlate serum and urine protein profiles collected before or after radiotherapy with clinical outcome in patients with prostate cancer. * identify protein profiles that can distinguish between patients with no evidence of disease and those with biochemical and/or clinical failure. * determine whether those serum proteomic profiles consistent with failure can be identified at early time points in the course of treatment and follow-up of these patients. outline: patients are stratified according to clinical outcome (prior to radiotherapy vs no evidence of disease vs biochemical failure vs clinical failure vs clinical outcome not yet determined). urine and blood specimens are collected from patients either before or after definitive radiotherapy. samples are analyzed by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry to develop proteomic patterns. results of proteomic profiles do not influence patient care. projected accrual: a total of 150 patients (30 per stratum) will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed prostate cancer * completed or planned definitive radiotherapy patient characteristics: age * adult performance status * not specified life expectancy * not specified hematopoietic * not specified hepatic * not specified renal * not specified prior concurrent therapy: biologic therapy * concurrent immunotherapy allowed chemotherapy * concurrent chemotherapy allowed endocrine therapy * concurrent hormonal therapy allowed radiotherapy * see disease characteristics * concurrent palliative radiotherapy allowed surgery * no prior prostatectomy, including radical prostatectomy * no concurrent radical prostatectomy

Keywords: recurrent prostate cancer stage i prostate cancer stage iib prostate cancer stage iia prostate cancer stage iii prostate cancer stage iv prostate cancer
a comparison of the timi, grace and heart scores

Conditions: Acute Coronary Syndrome

Summary: various elements of patient history are checked and entered in the admission case recor form (crf). three risk scores are calculated out of these elements, combined with physical examination, laboratory values and ecg-findings. the primary aim is to assess the positive and negative predictive values for a cardiovascular event of the three risk scores for chest pain patients. secondary aim is to assess the sensitivity and specificity of various elements in the patient history for an acute coronary syndrome.

this is a prospective, observational study in patients admitted to the emergency room for chest pain. all patients are checked by the resident in charge immediately on admission, before any lab values are known, by means of an admission case report form (crf), consisting of classical elements of patient history, risk factors, medication and physical examination. this crf is filled out immediately by the resident. no additional effort will be asked of the patients. patient data during a follow up of at least 6 weeks are gathered from hospital charts. the predictive value of the three scoring systems: heart (history, ecg, age, risk factors, troponin), timi (thrombolysis in myocardial infarction) and grace (global registry of acute coronary events) for both the discharge diagnosis and the occurrence of major adverse cardiovascular events (mace) is calculated. the primary hypothesis of the study is that the heart score is a significantly better predictor than the timi and/or grace score for cardiovascular events during a six week period following admission to the emergency room.

Eligibility criteria:
inclusion criteria: * any patient visiting the cardiology emergency room due to chest pain exclusion criteria: * chest pain clearly due to rhythm disturbances or acute heart failure * concomitant non cardiac disease with expected fatal outcome within 1 year

Keywords: risk scores acs heart-score
a pharmacokinetics study for pediatric participants with pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: the purpose of this study is to see how much study drug is in the blood of children with pulmonary arterial hypertension (pah) after dosing to establish the correct dose for further clinical research.

during period i, tadalafil will be administered orally, once daily, at a low dose for approximately 5 weeks followed by a high dose for approximately 5 weeks. dose levels are calculated based on body weight cohorts. heavy weight cohort \>=40 kg, middle weight cohort \>=25 kg to \<40 kg. light weight cohort\<25 kg. participants who complete period 1 may continue taking tadalafil in period 2 for at least 2 years. starting dose will not exceed the maximum weight range dose established in period 1 and after the first 3 months of period 2, the dose may be adjusted based on available safety and efficacy information.

Eligibility criteria:
inclusion criteria: * currently have a diagnosis of pah that is either: * idiopathic (including hereditary), related to collagen vascular disease, related to anorexigen use, associated with surgical repair, of at least 6 month duration, of a congenital systemic to pulmonary shunt (for example, atrial septal defect, ventricular septal defect, patent ductus arteriosus). * have a history of the diagnosis of pah established by a resting mean pulmonary artery pressure ≥25 mm hg, pulmonary artery wedge pressure ≤15 mm hg, and a pulmonary vascular resistance (pvr) ≥3 wood units via right heart catheterization. in the event that a pulmonary artery wedge pressure is unable to be obtained during right heart catheterization, participants with a left ventricular end diastolic pressure \<15 mm hg, with normal left heart function, and absence of mitral stenosis on echocardiography can be eligible for enrollment * have a world health organization (who) functional class value of i, ii or iii at the time of enrollment exclusion criteria: * have pulmonary hypertension related to conditions other than specified above, including but not limited to chronic thromboembolic disease, portal pulmonary hypertension, left-sided heart disease or lung disease and hypoxia * history of left-sided heart disease, including any of the following: * clinically significant (pulmonary artery occlusion pressure \[paop\] 15 to 18 mm hg) aortic or mitral valve disease (that is, aortic stenosis, aortic insufficiency, mitral stenosis, moderate or greater mitral regurgitation) * pericardial constriction * restrictive or congestive cardiomyopathy * left ventricular ejection fraction \<40% by multigated radionucleotide angiogram (muga), angiography, or echocardiography * left ventricular shortening fraction \<22% by echocardiography * life-threatening cardiac arrhythmias * symptomatic coronary artery disease within 5 years of study entry as determined by the physician * history of atrial septostomy or potts shunt within 3 months before administration of study drug * unrepaired congenital heart disease
kidney biomarkers of acute kidney injury in patients with knee arthroplasty

Conditions: Arthroplasty, Replacement, Knee; Acute Kidney Injury

Summary: sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. the aim of the present study is to evaluate use of sensitive renal markers, ngal (neutrophil gelatinase associated lipocalin ), kim-1 (kidney injury molecule- 1), lfabp (liver-type fatty acid-binding protein), and il-18 (interleukin -18), in patients coming for elective tka (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.

acute renal deterioration is a serious adverse event in elective surgery. serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. in recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration.

Eligibility criteria:
inclusion criteria: * informed consent * allergy to nsaids exclusion criteria: * no informed consent

Keywords: total knee arthroplasty kidney function renal markers
ultra-low-dose cacs in a large population

Conditions: Coronary Artery Disease

Summary: radiation exposure to patients from ct for cac scoring has steadily decreased in recent years. this is mainly achieved through lowering tube currents alongside with the introduction of iterative reconstruction algorithms which allow compensating for increased image noise. however, the greatest radiation dose reduction can be obtained by reducing peak tube voltage. yet lowering peak tube voltage remains challenging because tissue attenuation is closely related to photon energy, thus rendering the established thresholds for calculating cac scores (i.e. agatston scores) incomparable if peak tube voltages other than the standard 120 kilovolt peak (kvp) are applied. the investigators have developed novel tube-adapted thresholds for cac scoring by ct at 80 kvp and 70-kvp tube voltage and have shown that these novel thresholds are valid, yielding results closely comparable to the standard 120-kvp protocol. the present study aims to optimize application of such low-dose scans in a general population through assessment of the impact of physiological patient parameters on image parameters such as image noise which per se may impact the accuracy and feasibility of ultra-low-dose cac scoring with reduced tube voltage. furthermore, the prognostic performance of such low-dose cac scoring will be elucidated.


Eligibility criteria:
inclusion criteria: * patients referred for a non-contrast enhanced ct scan for cac scoring * male and female subjects ≥18 years of age, * written informed consent exclusion criteria: * pregnancy or breast-feeding * cacs of 0 after inclusion of 50 patients with cacs 0 (as assessed visually after the first ct scan, prior to performing the 3 additional study scans) * history of coronary artery stenting, coronary artery bypass grafting, of implantation of cardiac devices (e.g. valve prosthesis, pacemaker, implantable cardioverter defibrillator etc.) * enrolment of the investigator, his/her family members, employees and other dependent persons
open-source artificial pancreas system use among people with type 1 diabetes mellitus in china

Conditions: Type 1 Diabetes Mellitus

Summary: this real-world observational study aims to reveal the current status of the open-source artificial pancreas system (aps) use among people with t1dm in china and assess the glycemic efficacy and potential related factors of the open-source aps.

this is a real-world observational study analyzing data on open-source artificial pancreas systems(aps) in people with t1dm in china. data will collected during clinical routine, questionnaires, standard-of-care laboratory tests, and cgm data among whom are willing to share. baseline data from before the start (up to -3 months) of the open-source aps system and follow-up data at 3, 6, 9, 12, and the following period will be analyzed when available. there are no medical interventions, extra visits, or laboratory tests planned outside the normal clinical routine. glycemic control and patient-reported outcomes during follow-up will be compared with glycemic control and patient-reported outcome data at baseline.

Eligibility criteria:
inclusion criteria: 1. diagnosed t1dm. 2. currently use open-source aps for at least 3 months. 3. willing and able to provide informed consent (or be a parent or other legally authorized representative) and to provide the data. 4. reside in china. exclusion criteria: none

Keywords: artificial pancreas system automated insulin delivery do-it-yourself closed loop open source
active games: increasing the attractiveness of active video game play for youth

Conditions: Child; Overweight; Sedentary Lifestyle

Summary: the purpose of this study is to look at the effects of active video game play on youth physical activity.

child obesity is increasing worldwide and has major implications for health, both during youth and later in life. physical activity declines sharply during adolescence, making ages 8-12 a critical period to encourage healthy exercise habits. increased childhood weight has been linked to sedentary leisure time activities, such as video games. "active video games" (avgs) are now being studied as a method to increase children's interest and participation in physical activity. although research indicates that avg play may lead to energy expenditure comparable to light/ moderate physical activity, children prefer sedentary video games to avgs and often find avgs boring. children do not play avgs as often or with the same intensity as traditional games/sports and lose interest in them; efforts must be made to increase the appeal of avgs so they are competitive with sedentary video games. this study will examine whether children's motivation to engage in avg play may be increased with greater autonomy, as well as whether increasing children's motivation to play avgs also increases their motivation to play sedentary video games.

Eligibility criteria:
inclusion criteria: * sedentary lifestyle * bmi between 5th and 95th percentile exclusion criteria: * taking any medications that affect energy use or eating * actively trying to lose weight * has any medical conditions that prevent him/her from safely joining in physical activity * exercises more than three times per week for one hour at a time * does not engage in more than 14 hours per week of screen-based activities * does not own an active video game system * plays active video games more than 30 minutes per week
evaluation of aqueous humor del-1 and il-17 levels in diabetic cataract patients

Conditions: Diabetic Group (n=30); Non-diabetic Group

Summary: by comparing del-1 and il-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.

developmental endothelial locus-1 (del-1) is a molecule related to endothelial cells and is a protein involved in intercellular interactions. it is generally associated with the development and function of endothelial cells lining the inner surface of the vessel. it plays an important role in the regulation of inflammation, the development of vessels and the organization of endothelial cells. it has also been shown to be associated with some types of cancer. it may also be effective in tissue regeneration and healing of injuries. il-17 (interleukin-17) is a group of cytokines that play an important role in the immune system. there are several subtypes of il-17, the best known and most researched being il-17a. it regulates the body's immune response to certain infections. it is an important cytokine that initiates and supports the inflammation process. il-17 plays an important role in the pathogenesis of various autoimmune and inflammatory diseases. del-1 and il-17 are two different molecules that act on inflammation and immune responses. del-1 helps regulate inflammation by protecting vascular health, while il-17 can accelerate the course of diseases by increasing inflammation. diabetes is a systemic disease associated with oxidative stress and chronic inflammation. retinopathy, cataract and glaucoma diseases develop due to diabetes. del-1 is a protein involved in the maintenance of vascular homeostasis and regulation of inflammation. since diabetic patients have chronic inflammation and microvascular dysfunction, changes in del-1 levels may provide important clues to the pathophysiology

Eligibility criteria:
inclusion criteria: * cataract diagnosed and surgery planned * patients without any other ocular pathology other than cataract. * type 2 dm for at least 5 years in the diabetic group exclusion criteria: * patients with previous intraocular surgery * those with inflammatory eye diseases (e.g. uveitis) * those with autoimmune diseases or systemic inflammatory diseases * those receiving local or systemic steroid therapy * those with severe systemic disease (e.g. advanced renal failure, malignancy)

Keywords: diabetes mellitus cataract aqueous humor del 1 il17