Kornimate/medical-research-clean huggingface dataset:
effectiveness of mobility exercises in resistance-trained males with shoulder immobility in different age groups

Conditions: Mobility Limitation; Exercises

Summary: the shoulder is a dynamic and mobile joint between the arm and the trunk. the movement of the joint in three dimensions performs complex movements in almost every activity of daily life. these movements performed during activities of daily living can cause musculoskeletal problems and shoulder pathologies. for this reason, the shoulder joint should be carefully evaluated, especially in athletes.

the shoulder consists of four functional joints. glenohumeral joint (gh), acromioclavicular joint (ac), sternoclavicular joint (sc), and scapulothoracic joint (st). the most mobile of these four joints is the glenohumeral joint, located between the scapula and the glenoid. the gh is a synovial joint that has three-dimensional motion, covers the intra-articular capsule, and wraps the biceps long head tendon to the biceps sulcus. the glenohumeral capsule, glenohumeral ligament, and coracohumeral ligament contain a capsuloligamentous complex structure. this complex structure and the rotator cuff tendons form a static and dynamic restrictive structure around the glenohumeral joint. the rotator cuff space forms a triangular tissue between the edge of the anterior supraspinatus tendon and the superior subscapularis, and the apex is located on the lateral ridge of the biceps sulcus at the edge of the humeral ligament. after providing mobility, movement and balance will return to stability. increasing muscle strength for joint stabilization is a physical training goal for the shoulder in athletes. bone mechanics, intra-articular pressure, glenohumeral labrum and capuloligamentous structures are static components. dynamic components are provided by muscle activity coordinated around the joint and modulated by the neuromuscular system. the basis of static and dynamic interactions is mainly proprioceptive inputs that occur with mechanoreceptors in the muscles, joint capsule ligaments, tendons and skin, which are integrated into each other. joint stabilization is provided by the coactivation force of dynamic shoulder stabilizers. the balance of such forces must be proportional. for this reason, exercises to provide joint stabilization should aim to provide equal force distribution around the joint. among the criteria for evaluating the athletes; proprioception and range of motion. body awareness questionnaire aims to evaluate body awareness. posture will be evaluated with new york posture analysis. as a result of the literature review carried out; as far as is known, there is no adequate, up-to-date and evidence-based study in the literature.

Eligibility criteria:
inclusion criteria: * resistance-trained males over the age of 18 with shoulder immobility. exclusion criteria: * the criteria for exclusion from the study were: having orthopedic or neurological problems, and having undergone upper extremity musculoskeletal surgery. * female resistance-trained, * athletes under the age of 18 will not be included in the study.

Keywords: exercise body builders
short duration combination therapy with daclatasvir, asunaprevir, bms-791325 and sofosbuvir in subjects infected with chronic hepatitis-c (fourward study)

Conditions: Hepatitis C

Summary: the purpose of the study is to determine whether the combination of daclatasvir (dcv), asunaprevir (asv), bms-791325 and sofosbuvir is effective and safe in treating hepatitis-c virus.

allocation: initial therapy: randomized controlled trial: participants are assigned to intervention groups by chance rescue therapy: nonrandomized trial: participants are expressly assigned to intervention groups through a non-random method such as physician choice number of arms: initial therapy: 2 groups rescue therapy: 2 groups

Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com. inclusion criteria: * males and females ≥18 years of age, inclusive * chronic hcv infection genotype 1 only * non-cirrhotic * treatment naive subjects with no previous exposure to an interferon formulation (ie, ifnα, pegifnα), ribavirin (rbv) or hcv direct acting antiviral (daa) (protease, polymerase inhibitor, etc.) exclusion criteria: * hcv genotype other than genotype 1 * documented or suspected hepatocellular carcinoma * evidence of decompensated liver disease * contraindication(s) to peg/rbv therapy
fenofibrate for patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid

Conditions: Primary Biliary Cirrhosis

Summary: ursodeoxycholic acid (udca) has been the only treatment for pbc approved by us and european drug administrations. long-term use of udca(13-15 mg/kg/day) in patients with pbc improves serum liver biochemistries and survival free of liver transplantation however, about 40% of patients do not respond to udca optimally as assessed by known criteria for biochemical response. those patients represent the group in need for additional therapies, having increased risk of disease progression and decreased survival free of liver transplantation. both lab research and some clinical studies suggest that fenofibrate could improve cholestasis in multiple ways including reduce of bile acid synthesis, increase of biliary secretion and anti-inflammation effect. here we start a random, open and parallel clinical research to explore the effect of fenofibrate in the pbc treatment.


Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. patient with pbc defined by 2 in 3 of the following criteria: a.positive antimitochondrial antibody type m2; b.abnormal serum alkaline phosphatases (alp \> 1,5n) and aminotransferase (ast or alt \> 1n) activities; c.histological hepatic injuries consistent with pbc. 3. had been treated with udca more than 6 months, and failed to achieve a complete biochemical response. exclusion criteria: 1. pregnancy or desire of pregnancy. 2. breast-feeding. 3. co-existing liver diseases such as acute or chronic viral hepatitis, alcoholic liver disease, choledocholithiasis, autoimmune hepatitis, biopsy-proven non-alcoholic fatty liver disease, wilson's disease and hemochromatosis. 4. history or presence of hepatic decompensation (e.g., variceal bleeds, encephalopathy, or poorly controlled ascites). 5. history of urolithiasis, nephritis or renal failure (clearance of creatinine \< 60 ml/mn). 6. hepatotoxic drugs use before recruiting. 7. fenofibrate anaphylaxis.

Keywords: pbc udca fenofibrate
pet/ct in the management of patients with early stage endometrial cancer

Conditions: Endometrium Cancer

Summary: endometrial cancer (ec) is the most common gynecologic malignancy in the developed countries and is the fifth most common cancer among women worldwide. typically present well or moderately differentiated, early stage endometrioid histotype with a prognosis usually favorable. pelvic lymph nodes (lns) represent the most common site of extra-uterine disease in patients with clinical early stage disease and the role of lymphadenectomy in early stage ec has been one of the major controversies in gynecology oncology. lymphadenectomy doesn't improve survival or reduce disease recurrence although supported to provide prognostic information and allowing tailoring of adjuvant therapy. nevertheless, lymphadenectomy is not performed without serious short-term and long-term morbidity. although surgical staging is the most accurate and standard method to determine lns involvement, the introduction in clinical practice of a non-invasive modality that allows an accurate staging of ec would be essential. available evidence report the accuracy of positron emission tomography and computed tomography (pet/ct) for the detection of ln metastasis in ec with a sensitivity of 63% and specificity of 94.7%. this prospective comparative analysis between pet/ct, histological findings, and follow up data will be performed to investigate the sensitivity, specificity, positive predictive value (ppv), negative predictive value (npv) and accuracy of integrated pet/ct for nodal staging of ec per patient and per ln chain analyses, in women affected by intermediate (grade 1 and 2 endometrioid lesions with deep myometrial invasion \> 50% or grade 3 endometrioid lesion with \ 50% or non-endometrioid histotype) early-stage ec. furthermore, the preoperative classification of ec in intermediate and high-risk class will allow to investigate its prognostic value.


Eligibility criteria:
inclusion criteria: * women with diagnosis of early stage intermediate and high-risk endometrial cancer. exclusion criteria: * not eligible for standard surgical treatment; not eligible for preoperative staging with pet/ct

Keywords: endometrial cancer positron emission tomography
video clips for diagnostic evaluation of obstructive sleep apnea in children

Conditions: Obstructive Sleep Apnea (OSA)

Summary: obstructive sleep apnea (osa), which occurs in 1-4% of children, is a serious condition where a person stops breathing periodically during sleep because their airway closes. untreated, it is associated with high blood pressure, behavioural problems, and lower quality of life. while early diagnosis and treatment are critical, there are significant barriers to access to a sleep study (the best diagnostic test). questionnaires and overnight oxygen level recordings are limited in their ability to identify osa. better screening tools are needed to identify and prioritize children for sleep study testing. short video clips, recorded using smartphones by parents, may be a useful tool to identify children at risk of osa who would most benefit from a sleep study. the study aims to evaluate the ability of home smartphone video clips as a screening tool for moderate-severe osa in children referred for a sleep study. the utility of video clips will also be compared to questionnaires and overnight oxygen saturation recordings. the investigators believe that the video clips will be able to predict moderate-severe osa in children and that they will be better than standard clinical questionnaires or oxygen recordings. this multi-centre study will include 625 children referred for sleep studies for suspected osa. parents will be asked to record short video clips of their child sleeping, which will be rated for the presence and severity of osa. children will then undergo a sleep study, and parents will complete a questionnaire about sleep symptoms. oxygen level recordings will be extracted from the sleep study. the diagnostic accuracy of video clips will be determined and compared to the questionnaire and oxygen level recording. this new approach to screening for pediatric osa using widely available technology will allow children at the highest risk for moderate-severe osa to be diagnosed and treated earlier, minimizing the risk of long-term complications.


Eligibility criteria:
inclusion criteria: * 2-18 years old * referred for diagnostic psg to assess for osa at their local tertiary care centre * parent/caregiver has access to mobile technology exclusion criteria: * previous diagnosis of sleep-disordered breathing based on psg in the last five years * unable to cooperate for psg * clinician-suspected presence of central sleep apnea or central hypoventilation * genetic or congenital syndrome * non-verbal * use of pap therapy or tracheostomy * parent/caregiver does not speak english or french

Keywords: obstructive sleep apnea polysomnography videos
expression of amp-activated protein kinase (ampk) protein in lung adenocarcinoma

Conditions: Lung Adenocarcinoma

Summary: amp-activated protein kinase (ampk) is an evolutionally conserved protein kinase that serves as an energy guardian to help cells adapt to various metabolic stress including hypoxia. because the role of ampk in cancers has not been fully elucidated, in this study we investigated the expression and activation of ampk in lung adenocarcinoma (ladc) cells and tissue.


Eligibility criteria:
inclusion criteria: * lung cancer received operation lobectomy in cmuh exclusion criteria: * history of uremia, other malignant disease, and liver cirrhosis * history of pneumonia and pulmonary tuberculosis * history of long period of medications.

Keywords: amp-activated protein kinase lung adenocarcinomas prognosis observation study
subconjunctival atropine and intracameral epinephrine for pupil dilation in phacoemulsification

Conditions: Cataract; Mydriasis; Adverse Drug Event

Summary: mydriatic eye drops are routinely used before phacoemulsification but they are not free of drawbacks. several alternatives were tried to overcome their limitations.

the study will include 20 patients with bilateral cataract (40 eyes). the experimental group will include eyes for which a new injectable mydriatic combination are used to dilate the pupil. the control group will include cases where standard mydriatic eye drops are used.

Eligibility criteria:
inclusion criteria: * cases of bilateral visually significant cataract exclusion criteria: * poor pupil dilation(less than 6 mm diameter). * history of previous eye surgery or trauma * history of use of eye drops affecting pupil size such as pilocarpine. * known drug allergy to cyclopentolate,phenylephrine, atropine sulfate or epinephrine. * pediatric age group (less than 18 years old). * pupil abnormalities, such as anisocoria or neurological disorders. * associated glaucoma, uveitis, corneal, retinal or optic nerve disease. * cases scheduled for phacoemulsification under general anaesthesia (to exclude possible ocular and systemic effects or interactions of anaesthetic agents). * patients with bleeding tendency or on anti-coagulant therapy (because peribulbar and subconjunctival injections are used).

Keywords: intraoperative mydriasis subconjunctival atropine intracameral epinephrine cataract surgery
impact of a diabetes risk score on lifestyle education and patient adherence

Conditions: Pre-diabetes; Diabetes Risk Score; Motivation

Summary: the purpose of this randomized, controlled study is to evaluate whether the knowledge of a personalized diabetes risk score affects adherence to a 12-week diet and exercise lifestyle change program in prediabetic patients. the intervention group will receive diabetes risk score results at the beginning of the twelve weeks, and the control group will not receive these results. both groups will review their baseline and 12-week diabetes risk score results at the conclusion of the program and will be followed for an additional twelve weeks. attendance rates and changes in weight, bmi, abdominal circumference, blood pressure, hga1c, fasting blood glucose, cholesterol, and diabetes risk score will be compared between the groups.


Eligibility criteria:
inclusion criteria: * men and women of all ethnic groups * ≥30 -75 years of age * pre-diabetic defined as follows: fasting plasma glucose (fpg) 100-125mg/dl, hba1c 5.7% to 6.4%. * body mass index ≥ 25 kg/m2 * tricare beneficiary exclusion criteria: diagnosis of type 1 or type 2 diabetes mellitus (defined as fpg ≥126 mg/dl on two different occasions or random blood sugar ≥200) if fasting glucose \>= 126 only once, a second lab does not need to be arranged in an attempt to diagnose diabetes. it is acceptable for the patient to proceed in the trial. also, tethys lab results (e.g., fasting glucose and a1c) should not be used to make decisions about including or excluding patients in the trial. only air force lab results should be used to make this determination. * active duty military members * patients with untreated hypothyroidism or previously diagnosed cushing's syndrome * subjects previously treated with metformin or thiazolidinediones in the previous 12 months * psychological or physical disabilities deemed likely to interfere with participation in the study * patients currently using weight-loss medications or medications known to affect body weight (i.e. chronic corticosteroid use) * major medical conditions that prevent participation in the group lifestyle balance prevention program (i.e. severe cardiovascular or cerebrovascular disease, severe renal or liver dysfunction, etc.) * concurrent participation in a different weight loss program * previous bariatric surgery * unwilling to agree with the study assignments or provide informed consent * participation in any other research project that would interfere with this protocol * unable to read and write english * pregnant or nursing patients * female patients unwilling to undergo a pregnancy test or report possible pregnancy promptly and unwilling to take precautions to avoid pregnancy if potentially fertile during the study course discontinuation criteria: * consent is withdrawn * death occurs * a woman becomes pregnant * severe impairment of manual dexterity, vision, or intellectual function * they become lost to follow-up because of a move or transfer outside of the geographic area

Keywords: pre-diabetes diabetes risk score motivation air force military lifestyle change
pinch grafting versus second intention wound healing for mohs micrographic surgery defects on the scalp

Conditions: Scarring

Summary: oftentimes, following surgery on the scalp, wounds are left to heal by themselves. this is called "second intention." open wounds left to heal on the scalp often take 8 weeks or more to completely heal. the investigators are investigating how second intention closure compares to another established reconstruction technique, called "pinch graft." in the pinch graft technique, a dermatological surgeon numbs and then shaves off a thin piece of skin (usually from the groin area) and places it in the wound bed it (also known as "grafting"), to encourage growth of new healthy skin. this study will compare time-to-healing in the second intention method versus the pinch graft method.

pinch graft methodology was first developed in 1976 as a treatment to accelerate healing of lower leg ulcerations, particularly venous or gravitational ulcerations (1, 2). it was later adapted as a tool to hasten healing in surgical wounds, such as surgical closure of diabetic foot wounds (3). it has also been used in the healing of patients with wounds related to dystrophic epidermolysis bullosa (4). more recently, pinch grafts have been investigated as a reconstruction option for mohs micrographic surgery defects (5). in this study, patients with below the knee mohs surgical defects were randomized to receive either pg reconstruction or sih reconstruction. patients with pg reconstruction healed 20 days sooner (i.e., faster time to reepithelialization) than those who underwent sih. complication rates, including infection and reported pain, were also lower in the pg cohort compared to the sih cohort. sih is often recommended as a reconstruction technique for surgical wounds without adjacent skin laxity to support primary closure, such as the anterior lower extremity and scalp. there is no study to date examining the use of pinch grafts in scalp wounds. in our study, the investigators explore whether pg is a viable and useful reconstruction method for wounds on the scalp that otherwise would be left to close via sih. specifically, in our study, the investigators examine the comparative time to healing and complication rates between pg and sih in mohs surgical defects of the scalp.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * able to give informed consent themselves * patient scheduled for cutaneous surgical procedure on the scalp with predicted second intention closure * willing to return for follow up visit * active user of mychart * willing to send weekly messages until wound is healed exclusion criteria: * incarceration * under 18 years of age * pregnant women * unable to understand written and oral english * scalp wounds with planned primary repair reconstruction * surgical defects with bone exposure * no mychart access or use

Keywords: pinch graft
effects of acetazolamide and co2 inhalation on exercise-induced periodic breathing in heart failure

Conditions: Chronic Heart Failure

Summary: to evaluate the effects of co2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. patients will be given co2 (2%) during a constant workload exercise. patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.


Eligibility criteria:
inclusion criteria: * chronic heart failure in stable clinical condition * exercise-induced periodic breathing exclusion criteria: * comorbidities * nyha class iv

Keywords: heart failure, exercise periodic breathing, acetazolamide
study to investigate the effects of azd6140 in patients with renal impairment and in healthy volunteers

Conditions: Renal Impairment

Summary: the main purpose of this study is to examine how azd6140 affects patients with severe kidney disease compared to volunteers with normal kidneys. subjects in the study will receive one dose of azd6140.


Eligibility criteria:
inclusion criteria: * patients must have severe kidney disease * subjects who are matched to the kidney disease patients in terms of weight, age, and sex must have normal kidneys * all women must be post-menopausal (no longer menstruating) or surgically sterile exclusion criteria: * patients requiring dialysis * history of allergy to aspirin or clopidogrel * have increased bleeding risk (for instance uncontrolled high blood pressure or a recent major injury) * recent history of fainting or light-headedness

Keywords: renal impairment
risk of stroke and silent cerebrovascular thromboembolism after cardioversion of atrial fibrillation

Conditions: Atrial Fibrillation; Cardioversion; Cerebrovascular Stroke

Summary: patients with atrial fibrillation undergoing cardioversion will be randomized to undergo transesophageal echocardiography or they will receive warfarin for 3 weeks with an international normalized ratio (inr) value between 2.0-3.0. those who do not want to use warfarin will be given an approved new oral anticoagulant agent instead of warfarin for 3 weeks. if thrombus is detected in left atrium or in left atrial appendage, no cardioversion will be performed. other patients in the both groups will undergo electrical cardioversion. after the procedures all the patients will be given oral anticoagulant for at least 4 weeks. all patients will have neurological examination and diffusion magnetic resonance imaging (mri) at baseline and at postprocedural 7th day. clinical and subclinical cerebral thromboembolic events detected by diffusion mri will be recorded. any bleeding events will also be recorded.


Eligibility criteria:
inclusion criteria: * patients with the age of more than 18 years who are planned to undergo electrical or medical cardioversion exclusion criteria: * urgent cardioversion * patients who have implanted pace-makers or other metal devices * claustrophobia * hematological disorders disabling patients to receive anticoagulant agents * atrial fibrillation secondary to temporary causes. * serious rheumatic heart valve disease * hyperthyroidism * history of malignancy * left atrium diameter \> 55 mm * ejection fraction \< 0.25

Keywords: atrial fibrillation, conversion, stroke