Kornimate/medical-research-clean huggingface dataset:
efficacy of character strengths intervention in enhancing character strengths and self-esteem among adolescents

Conditions: Mental Health Issue; Mutism; Orthopedic Disorder

Summary: the goal of this study is to better understand the experiences of adolescents with physical disabilities and assess the effectiveness of a character strengths intervention (csi) in improving their self-esteem, character strengths, and mental health. we will also compare these outcomes between two groups: one receiving the intervention and the other not receiving any treatment. main research questions: how do adolescents with physical disabilities perceive their self-esteem, character strengths, and mental health, including psychological adjustment, psychological distress, psychological wellbeing, life satisfaction, and resilience? can the character strengths intervention (csi) enhance the self-esteem, character strengths, and mental health (psychological adjustment and distress) of adolescents with physical disabilities? study tasks: participants, who are adolescents aged 12-18 years, will be asked to provide informed consent to participate in the study. they will complete questionnaires to assess their self-esteem, character strengths, and mental health as a pre-assessment. participants in the intervention group will undergo the character strengths intervention (csi), which includes activities like exploring character strengths, writing gratitude letters, and practicing fresh look meditation, among others. after the intervention, participants will complete post-assessment questionnaires to measure changes in self-esteem, character strengths, and mental health. there will be a control group that does not receive any treatment. comparison group: researchers will compare the outcomes between the intervention group, who received the character strengths intervention (csi), and the control group, who did not receive any treatment. this will help us determine if the intervention had a significant impact on self-esteem, character strengths, and mental health outcomes for adolescents with physical disabilities.


Eligibility criteria:
inclusion criteria: 1. adolescents with physical disability 2. adolescents with physical disability in the age range 11-18 3. rural and urban residences 4. urdu, englishspeaking 5. rawalpindi and islamabad special education schools exclusion criteria: 1. adolescents under age 11 and above 18 2. adolescents whose parents, teachers, or themselves would not be agreed and signed informed consent to participate in the study would be excluded 3. adolescents with physical disability such as: * sensory disability (mute and fully/partial-visual impairment) impairment * hearing impairment * deaf-blindness * and intellectual and cognitive impairment 4. adolescents with severe psychiatric and major medical issues -

Keywords: adolescents with physical disability
diaphragm's manual therapy in patients with chronic neck pain

Conditions: Neck Pain

Summary: the aim of this study is to evaluate the effect of diaphragm's manual therapy in addition to cervical spine manual therapy in terms of pain, cervical spine range of motion, trigger points pain pressure threshold, disability and quality of life in patient with chronic aspecific neck pain.


Eligibility criteria:
inclusion criteria: * neck pain since at least 3 months * age \> 18 years and \< 65 years * male or female exclusion criteria: * pregnancy * contraindications for manual therapy or inability to complete the treatment * patients who received a physiotherapy or osteopathic treatment during the last 3 months * medical diagnosis of rheumatologic disease * medical diagnosis of respiratory disease (copd, asthma) * spine surgery * medical diagnosis of past or present cancer * thoracic or abdominal surgery in the last 3 years * whiplash injuries * previous cervical fracture * cervical anatomical changes * thrombotic events * body temperature greater than 37 degrees in the previous 48 hours * obesity (bmi greater than 30)

Keywords: cervical spine; diaphragm; manual therapy pain range of motion
a study of ly3471851 in adults with systemic lupus erythematosus (sle)

Conditions: Systemic Lupus Erythematosus

Summary: the reason for this study is to see if the study drug ly3471851 (nktr-358) is safe and effective in adults with systemic lupus erythematosus (sle).

ly3471851 is a potential first-in-class therapeutic that may address an underlying immune system imbalance in people with many autoimmune conditions. it targets the interleukin (il-2) receptor complex in the body in order to stimulate proliferation of inhibitory immune cells known as regulatory t cells. by activating these cells, ly3471851 may act to bring the immune system back into balance.

Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of sle at least 24 weeks prior to screening. * have documentation of having met at least 4 of 11 revised criteria for classification of systemic lupus erythematosus according to the 1997 update of the 1982 american college of rheumatology (acr) criteria for classification of sle prior to randomization. * have a positive antinuclear antibody (ana) (titer ≥1:80) and/or a positive anti-double-stranded deoxyribonucleic acid (dsdna), and/or a positive anti-smith (anti-sm) as assessed by a central laboratory during screening. * have a total systemic lupus erythematosus disease activity index 2000 (sledai-2k) score ≥6 during screening. * have a clinical sledai-2k score ≥4 at randomization. * have active arthritis and/or active rash. exclusion criteria: * have severe active lupus nephritis. * have active central nervous system (cns) lupus. * have a history or presence of cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, hematological, neurological, or neuropsychiatric disorders or any other serious and/or unstable illness that, in the opinion of the investigator, could constitute an unacceptable risk when taking investigational product or interfere with the interpretation of data. * have a current or recent clinically serious viral, bacterial, fungal, or parasitic infection.

Keywords: t regulatory cells (tregs) interleukin 2 interleukin-2
a randomized controlled trial of three non-pharmacologic analgesic techniques for casting of clubfoot infants

Conditions: Clubfoot

Summary: while it has been shown that sucrose or milk ingestion decreases pain responses in heel sticks, no study up to this point has determined the best intervention for decreasing the pain response during casting for clubfoot deformity. the goal of this study is to investigate the effect of three different non-pharmacologic interventions (sucrose, milk, water) on pain response during clubfoot casting. this study will allow us to discern the best non-pharmacologic intervention for pain control during clubfoot casting and to provide a more pleasant, comfortable experience for patients and families.

clubfoot deformity in newborns is common, occurring in 1-2/1000 births. treatment of this deformity has shifted from surgical to non-surgical management. the non-surgical management includes utilizing the ponseti technique of manipulation and casting, followed by achilles tenotomy and brace application. the newborn undergoes, on average, 4-6 casts before the foot deformity is corrected. during this manipulation and casting, the infants can become fussy and irritable. this irritability is likely due to discomfort felt from the manipulative process and subsequent casting. studies that have focused on decreasing the pain response to heel sticks for laboratory testing in the neonatal intensive care units used sucrose or milk ingestion and swaddling in newborns to decrease pain responses. both sucrose and milk have been shown to decrease the pain response as measured by the premature infant pain profile (pipp) or the bernese pain scale for neonates. in addition, other pain scales have been used in newborn babies including the cries, chipps, nips, and comfort scales to evaluate the effectiveness of pain relieving interventions. these scales were used alongside objective physiologic measurements such as heart rate, heart rate variability (hrv), respiratory rate, and oxygen saturation. while it has been shown that sucrose or milk ingestion decreases pain responses in heel sticks, no study up to this point has determined the best intervention for decreasing the pain response during casting for clubfoot deformity. the goal of this study is to investigate the effect of three different non-pharmacologic interventions (sucrose, milk, water) on pain response during clubfoot casting, allowing us to discern the best non-pharmacologic intervention for pain control during clubfoot casting and to provide a more pleasant, comfortable experience for patients and families. a secondary objective is to investigate whether or not family environment or the level of anxiety felt by the parents impacts the pain felt by the infant during the casting process.

Eligibility criteria:
inclusion criteria: * idiopathic clubfoot deformity * undergoing clubfoot casting for correction exclusion criteria: * cannot use a bottle for feeding * on solid food * have had surgery * have been given an analgesic within three hours prior to data collection
68ga-fapi pet/ct to detect ongoing fibroblast activity in post-acute covid-19

Conditions: Post-Acute COVID-19; Post-Acute COVID-19 Infection; Post-Acute COVID-19 Syndrome; Pulmonary Fibrosis

Summary: the goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a covid-19 infection. fibroblasts are involved in tissue remodeling and repair by creating scar-tissue (fibrosis) after tissue damage has occurred. the hypothesis is that this process of fibrosis is ongoing in patients with persistent complaints. to evaluate the roll of fibroblasts a new type of scan is used that is capable of imaging active fibroblasts, a 68ga-fapi pet/ct scan.

rationale: the pathogenesis of post-acute covid-19 with respiratory complaints remains unknown. we aim to explore the pulmonary pattern and fibrosis activity in patients with post-acute covid-19 with respiratory complaints using 68ga-fapi positron emission tomography-computed tomography (pet/ct) imaging. objective: to relate pulmonary fibroblast activity, measured by fapi-pet/ct at least 3 months after hospital discharge, to interstitial lung abnormalities on high resolution ct (hrct) at the same time point in post-acute covid-19 patients with respiratory complaints. study design: this is a zonmw funded single center prospective observational cohort study of post-acute covid-19 patients with respiratory complaints. study population: we will recruit 20 adult patients, all post-icu or post high-flow nasal oxygen therapy due to there covid-19 infection, with post-acute covid-19 and respiratory complaints that will undergo 68ga-fapi pet/ct imaging to establish pulmonary fibrosis activity. main study parameters/endpoints: to assess the degree of fibroblast activation protein expression on 68ga-fapi pet/ct at least 3 months after hospital discharge and to relate this to interstitial lung abnormalities on hrct at the same time point.

Eligibility criteria:
inclusion criteria: * male patients \>18 years and female patients \>20 years discharged from hospital after pcr-confirmed covid-19 infection. * previous icu or ward admission with high flow nasal oxygen (hfno) or mechanical ventilation. * persistent respiratory complaints (shortness of breath) at least 3 months after hospital discharge. exclusion criteria: * inability or unwilling to give informed consent. * history of claustrophobia or feeling of inability to tolerate supine position for the pet/ct scans. * severe or significant comorbidity, defined as copd gold stage ii or higher and/or known interstitial lung disease. * women who are pregnant or breastfeeding.

Keywords: 68ga-fapi-04 hrct post-icu post high-flow nasal oxygen therapy
a clinical study on albert wong frame-based stereotactic biopsy system for brain

Conditions: Intracranial CNS Disorder

Summary: this study is to establish a new, alternative stereotactic biopsy frame (aw frame) in the field of stereotactic neurosurgery.

aw frame is a stereotactic biopsy frame created by dr. albert sii hieng wong. a phantom study had completed by dr. bik liang lau and dr. albert sii hieng wong in year 2017 with good accuracy. the phantom study result is going to be submitted for publication by early 2019. with the good accuracy of aw frame in the phantom study, the frame has been approved by the medical research \& ethic committee (mrec) for human use in a research setting. in the study, patient with intracranial lesion which required biopsy, whom fulfilled the criteria will be recruited. all these patient will underwent standard biopsy procedure either under local or general anaesthesia with aw frame mounted. a localisation ct scanning will be perform with localiser fixed onto the head frame. target of the intracranial lesion is selected. the coordinates of the localizing points and the selected target inserted into the aw stereo-calculator to generate the aw frame setting up measurements. burr hole will be performed and biopsy taken by using nashold® biopsy needle. an immediate post-biopsy ct imaging will be performed to confirm the site of the biopsy. patient will be monitored in the neurosurgery ward for any complications. histopathologic analysis of the biopsies will be done using usual procedure.

Eligibility criteria:
inclusion criteria: * age \>17 years old * radiological diagnosis of intracranial space occupying lesion of any etiology exclusion criteria: * patient involved in other study trial * any serious medical condition that according to the investigator could interfere with the conduct of the study * unwillingness or inability to comply with study requirements

Keywords: aw frame biopsy stereotactic accuracy safety
treatment of chronic critical limb ischemia with g-csf-mobilized autologous peripheral blood mononuclear cells

Conditions: Critical Limb Ischemia; Atherosclerosis; Ischemic Ulcer; Gangrene

Summary: the purpose of this study is to determine the safety and efficacy of g-csf-mobilized autologous peripheral blood mononuclear cell injection to ischemic limbs of patients with critical limb ischemia.


Eligibility criteria:
inclusion criteria: * patients with critical limb ischemia confirmed by toe pressure, abi, tcom * levels of arterial occlusion are femoropopliteal or tibioperoneal occlusion * poor distal artery runoff * age 18-70 year exclusion criteria: * planned for major amputation within 4 weeks * receive blood component within 4 weeks * acute myocardial infarction * severe valvular heart disease * renal failure * liver failure * cancer * hypercoagulable state * severe infection * pregnancy

Keywords: critical limb ischemia atherosclerosis ischemic ulcer rest pain gangrene
effectiveness of autohypnosis in the prevention of anxiety during radiotherapy of head and neck tumors (hymaco)

Conditions: Head and Neck Tumors

Summary: hymaco is a monocentric, randomized comparative pilot study with a total duration of 25 months. the purpose of this study is to evaluate the effectiveness of autohypnosis by anchoring in the prevention of anxiety related to wearing the mask for radiotherapy of head and neck tumors. 60 patients will be randomized into 3 arms arm a : standard care arm b : autohypnosis arm c : musicotherapy this study is carried out during the first 5 radiotherapy sessions because this is decisive for the good progress of subsequent sessions


Eligibility criteria:
inclusion criteria: * age \> or =18 * patient to receive radiotherapy for a tumor of the head and neck, with a compression mask * patient who obtained a score equal to or greater than 56 on the stai form y-a questionnaire during the consultation with the radiotherapist before starting treatment * patient capable and willing to follow all study procedures in accordance with the protocol * patient who understood the study and gave informed consent * patient affiliated to a social security system exclusion criteria: * contraindication to hypnosis: psychosis, schizophrenia * non-french speaking patient * significant hearing loss * pregnant woman, likely to be, or breastfeeding * persons deprived of their liberty or under guardianship (including guardianship) * inability to undergo medical monitoring of the trial for geographical, social or psychological reasons * patient who has already received radiotherapy to the head or neck with a compression mask

Keywords: autohypnosis anxiety 5 points mask radiotherapy anchoring
a feasibility study of oral adjuvant chemotherapy with s-1

Conditions: Non-small Cell Lung Cancer

Summary: the investigators confirm the feasibility of 1-year administration of oral fluoropyrimidine s-1 as an adjuvant chemotherapy for the patient who received complete resection of non-small cell lung cancer. the investigators presume they can achieve high completion rate with low toxicity.

chemotherapy comprised eight courses (4-week administration, 2-week withdrawal) of s-1 (ft, gineracil, oteracil potassium; taiho pharmaceutical, tokyo, japan) at 80-120 mg/body/day according to body surface area (bsa): bsa \ 1.25 m2 but \ 1.5 m2, 120 mg/day. s-1 was administered orally, twice daily after meals, starting within 4 weeks after surgery.

Eligibility criteria:
inclusion criteria: 1. nsclc with histological proof. 2. pathological stage ib, ii, or iiia nsclc (fifth edition of uicc/ajcc 1997) after complete resection. 3. no prior treatment except for surgery. 4. sufficient oral intake. 5. performance status (ps) 0 or 1. 6. patients also had to have adequate organ function (3500 \ 100,000/mm3; total bilirubin,\<1.5 mg/dl; ast and alt, less than twice the normal limits at each institution; bun, \<25 mg/dl; creatinine, less than the normal limits at each institution; and creatinine clearance (ccr)) exclusion criteria: 1. history of drug hypersensitivity. 2. contraindication of oral s-1 administration (refer appended paper). 3. serious surgical or non-surgical complications 4. active secondary cancer. 5. watery diarrhea. 6. pregnant or lactating women. 7. male who has intention to make pregnant 8. patient to whom primary doctor judged inadequate to register.

Keywords: non-small cell lung cancer adjuvant chemotherapy oral fluoropyrimidine s-1 feasibility study surgery
a study of grazoprevir (mk-5172) in hepatitis c-infected male participants (mk-5172-004)

Conditions: Hepatitis C

Summary: this multiple dose study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of grazoprevir (mk-5172) in genotype (gt) 1 and gt3 hepatitis c virus (hcv)- infected participants. the primary hypothesis is that administration of grazoprevir for 7 days is sufficiently safe and well tolerated in hcv-infected males.


Eligibility criteria:
inclusion criteria: * baseline health is stable. * has a clinical diagnosis of chronic hcv infection. exclusion criteria: * has a history of stroke or chronic seizures. * has a history of cancer. * has a history of human immunodeficiency virus (hiv) infection. * has had major surgery, donated blood or participated in another investigational study within the past 3 months.
the effects of low-dose atropine and orthokeratology in pediatric myopia control

Conditions: Myopia

Summary: both orthokeratology and atropine eye drops are effective methods for myopia control, but few studies have compared them all together simultaneously. therefore, the primary aim of the present study was to compare the effect of orthokeratology versus low-dose (0.01% and 0.02%) atropine on the control of myopia progression.


Eligibility criteria:
inclusion criteria: best corrected visual acuity less then 0.00 log mar (minimum angle of resolution) units cycloplegic ser of - 1.0 d or less in both eyes. an inter-eye cycloplegic ser difference of 1.00 d or more. exclusion criteria: children with cycloplegic cylinder refraction of more than + 1.00 d or less than - 1.00 d. history of binocular vision problems, including strabismus. history of known ocular disorders, including media opacities, macular dysgenesis, optic nerve hypoplasia, perinatal brain injury, buphthalmos, and retinopathy of prematurity. history of medication use that might have affected the refractive results. systemic or developmental problems that might have hindered refractive development.
pharmacist-physician collaborative medication therapy management services (mtms) demonstration project

Conditions: Hypertension

Summary: patients managed by a newly formed pharmacist-physician medication therapy management team in a university primary care clinic will have better blood pressure control than patients receiving usual care.


Eligibility criteria:
inclusion criteria: * age 18 years or over * diagnosis of hypertension with most recent blood pressure \>140/90 mmhg or blood pressure \>130/80 mmhg if patients also had diabetes mellitus * treated with at least one anti-hypertensive medication * continuous active patient (at least one visit) of the clinic for at least the past 6 months (1/1/2010-6/31/2010) * english speaking * able to complete questionnaires in english. exclusion criteria: -do not meet provisions of the clinical collaborative agreement protocol in the judgment of the patient's physician or the clinical pharmacist