Kornimate/medical-research-clean huggingface dataset:
an analysis into the cause and preventional method of thromboembolic disease in gynecological surgery

Conditions: Thromboembolic Disease; Gynecological Surgery

Summary: the aim of this cross-sectional study is to describe the specific situations of thromboembolic disease in gynecological surgery and identify the risk factors of it.

the electronic medical data of 54 patients who undergo operations to treat gynecological diseases but develop thromboembolic disease will be analyzed retrospectively in this study. the location, symptom and other situations of embolism will be described and multiple linear analyse will be employed to identify the risk factors of it.

Eligibility criteria:
inclusion criteria: 1. volunteer to participate in the study with informed consent; 2. females aged 20-80 who are confirmed with some gynecological diseases and are treated with surgery but embolism happens unfortunately. exclusion criteria: 1. pregnancy, lactation, postmenopause, or planned pregnancy within two years; 2. patients with blood diseases prone to thrombosis and those with a history of thrombus were excluded; 3. history of hyperparathyroidism, infectious diseases (tuberculosis, aids), autoimmune diseases, or digestive system diseases (malabsorption, crohn disease and dysentery); 4. other diseases or heavy injuries that will interfere with the results; 5. simultaneous participation in another clinical study with investigational medicinal product(s) or researcher thinks the subjects are not suitable for this trial.
complementary medicine practices in chronic low back pain: randomized controlled trial

Conditions: Back Pain; Leeches; Chronic Pain

Summary: to compare the effectiveness of classical physiotherapy and leech therapy in patients with chronic low back pain.

investigators research will last 6 weeks in total. there will be a total of 60 participants in three groups, 20 people in each group. participation will be on a voluntary basis. there will be no control group in our study. physiotherapy treatments will be applied two days a week for a total of 6 weeks. in the group where leeches will be applied together with classical physiotherapy, leech application will be done every two weeks. however, in the group where leeches will be applied, the classical physiotherapy method will continue to be applied two days a week for a total of 6 weeks. roland morris disability questionnaire, oswestry disability index, short form mcgill pain questionnaire, pittsburgh sleep quality inventory (psqi) will be administered before and after our study.

Eligibility criteria:
inclusion criteria: * by a specialist physician (orthopedics, neurology, algology) for more than three months * low back pain confirmed throughout * complaint of lower back pain at least three days a week in the three months before treatment * those who do not have any blood disease * those who do not use blood thinners exclusion criteria: * regular intake of opioid analgesics * presence of hemophilia * presence of anemia or known erythropoietic disorder * presence of erosive gastritis, gastrointestinal bleeding or stomach ulcer in the last three months * immunosuppressive drugs * wound healing disorder * pregnancy, breastfeeding status * presence of rheumatoid arthritis, spondyloarthropathy or other inflammatory joint disease
study to understand risk information to support and empower

Conditions: Diabetes, Gestational; Diabetes Mellitus, Type 2

Summary: the aim of this trial is to test components of a digital health outreach intervention to promote uptake of postpartum screening and lifestyle programs for diabetes prevention among patients with gestational diabetes (gdm). the outreach intervention, designed to be interactive and delivered online, includes standard health information plus up to four theory-based components, targeting motivational and logistical barriers to engaging in diabetes preventive care during the postpartum period. the trial leverages the multiphase optimization strategy (most) using a randomized factorial study design.


Eligibility criteria:
inclusion criteria: * current pregnancy complicated by gestational diabetes mellitus (gdm) * age: 18 years and older * contact with the kaiser permanente northern california (kpnc) regional perinatal service center * able to communicate in english exclusion criteria: * diagnosis of diabetes before pregnancy * maternal or infant current hospitalization * pregnancy loss * history of eating disorder * previously requested not to receive research invitations

Keywords: gestational diabetes diabetes mellitus, type 2 prevention preventive health services health communication
efficacy and safety of spd476 in maintaining remission in patients with ulcerative colitis

Conditions: Ulcerative Colitis

Summary: ulcerative colitis is a disease of the large bowel (colon) and rectum in which the lining of the bowel becomes red and swollen. over time, patients with this disease may experience acute episodes of diarrhea, rectal bleeding and abdominal pain followed by periods of time without disease symptoms. 5-asa drugs are a standard treatment for ulcerative colitis. mesalazine is an experimental drug designed to gradually release 5-asa into the areas of large bowel associated with ulcerative colitis. this study will test the safety and efficacy of mesalazine in keeping ulcerative colitis in remission.


Eligibility criteria:
inclusion criteria: * previous diagnosis of ulcerative colitis confirmed by histology that has been considered to be in remission for =\> 30 days * female subjects must be post-menopausal, surgically or biologically sterile, or with a negative urine pregnancy test at screening and on adequate contraception exclusion criteria: * proctitis * previous resective colonic surgery * crohn's disease * hypersensitivity to salicylates * moderate/severe renal impairment
patient satisfaction and oral health-related quality of life (ohrql) for two pick-up techniques

Conditions: Prosthesis User

Summary: this study aimed to evaluate patient satisfaction and ohrql using two pick-up methods for locator retained mandibular overdenture


Eligibility criteria:
inclusion criteria: * 1. all selected patients will have two implants placed in the mandibular interforaminal region. 2. all selected patients have a healthy mucosa and have no clinical complications. 3. all patients are cooperative and approve of the proposed treatment protocol exclusion criteria: * 1. patients who refuse to participate in the study 2.patients who need implant placement as a result of previous implant failure
a clinical trial for the surgical treatment of elderly distal radius fractures

Conditions: Distal Radius Fracture

Summary: in the united states, over 300,000 individuals over age 65 suffer from distal radius fractures (drfs) each year. despite the frequency of this injury and over 200 years of experience treating drfs, management of elderly drfs is still controversial. close reduction and casting is a nonsurgical technique that is frequently used, but osteoporotic fractures, common in the elderly, often collapse and displace. the three currently applied surgical techniques are close reduction and percutaneous pinning, external fixation with or without percutaneous pinning, and internal fixation with volar locking plating. preliminary evidence indicates that locking plate fixation can permit elderly patients to move their hands and wrists much sooner in order to return to self-care activities more quickly. although these outcomes are promising, there is no randomized controlled clinical trial to demonstrate that the more invasive, and perhaps more costly, plating technique is superior to the other simpler approaches. the specific aim of this 24-center randomized controlled trial is to compare outcomes of these three surgical techniques in treating unstable drfs in the elderly. the secondary aim is to follow a cohort of elderly patients who choose not to have surgery to evaluate outcomes following treatment by close reduction and casting alone. this clinical trial is the most ambitious study in hand surgery by assembling most of the leading centers in north america to collect evidence-based data to guide future treatment of this prevalent injury in the growing elderly population.


Eligibility criteria:
inclusion criteria: * patients who have an unstable drf for which surgical fixation is indicated o ao type a2, a3, c1, c2 * at least one of the following radiographic criteria indicating fracture instability * dorsal angulation of greater than 10° * radial inclination angle of less than 15° * radial shortening of greater than 3mm * patients with the ability to read and understand english (to complete study questionnaires) * community-dwelling patients * patients 60 years of age or older exclusion criteria: * patients who have suffered open drfs * patients with bilateral drfs * patients with associated upper extremity fractures or ligament injuries (including ulnar styloid fracture, tfcc and wrist ligament injuries) requiring repair at the time of drf fixation * multi-trauma patients * patients with prior drf on the same wrist * patients with comorbid conditions prohibiting surgery * patients with neurologic disorders that affect hand, wrist or arm sensation or movement * patients who have a history of dementia, alzheimer's disease or other serious psychiatric disorders * patients with current substance abuse * patients who do not agree to be randomized * patients who have drfs that are not equally suited for each procedure (i.e. severely comminuted fractures)

Keywords: wrist distal radius fracture drf elderly internal fixation vlps external fixation multi center randomized trial
initial versus delayed operation for treatment of complicated appendicitis in children

Conditions: Perforated Appendicitis

Summary: to determine the most cost effective way to treat children with perforated appendicitis we will randomize all children presenting with perforated appendicitis to initial operation, with in 24 hours of admission, or to initial antibiotics, with or without percutaneous drainage, and subsequent interval appendectomy after 8 weeks. our outcomes will include cost, complications, length of stay, and quality of life measures.


Eligibility criteria:
inclusion criteria:children * age 2-17 with a diagnosis of perforated appendicitis exclusion criteria: * age \ 18 * pregnancy * immunocompromise

Keywords: appendicitis, perforated, children
influence of respiratory rate settings on co2 levels during nasal intermittent positive pressure ventilation (nippv).

Conditions: Ventilator Lung; Newborn

Summary: infants will be monitored by tcco2 during three consecutive time periods of one hour each on a high and low rate of nippv, when in a stable condition. nippv rate will start high/low, changed to low/high and switched back to starting rate.

this will be a prospective, crossover observational study that will be performed at rambam nicu. infants will be monitored by tcco2 during three consecutive time periods of one hour each on a high and low rate of nippv, when in a stable condition. nippv rate will start high/low, changed to low/high and switched back to starting rate.

Eligibility criteria:
inclusion criteria: * gestational age 240 to 336. * at least 6 hours of stabilized nippv settings, i.e. minor changes in settings (fio2 ≤0.10, pip≤ 2.0 cmh2o, rr≤ 5 brm). * at least 6 hours of stabilized tcco2, i.e. ≤5 mmhg variation. * at least 6 hours from surfactant administration. * parental consent exclusion criteria: * if nippv set rate is 10 bpm and tcco2 related pco2 is\<40mmhg. * if nippv set rate is 30 bpm and tcco2 related pco2 is\>60mmhg. * unstable infants due to acute conditions (sepsis. ivh), or congenital malformations.
open versus endovascular revascularization in patients with end-stage renal disease

Conditions: End-stage Renal Disease; Critical Limb Ischemia

Summary: treatment of patients with end-stage renal disease and critical limb ischemia still poses challenges to vascular medicine due to limited survival, comorbidities and infrapopliteal involvement of arteriosclerosis in these patients. most optimal vascular therapy mode has not been finally decided in these patients. therefore retrospective analysis of patients receiving open surgical and endovascular revascularisation was performed.

query of internal clinical database for identification of patients (2009-2017)with end-stage renal disease and critical limb ischemia, receiving either open surgical (group i "or") or endovascular revascularisation (group ii "evt"). furthermore, retrospective comparison as to morphological criteria (lesion length, peripheral run-off, plantar arch) and comorbidities. prospective follow-up of identified patients by means of telephone contacts and/or clinical examination of evaluation of long-term outcome measures (overall survival, amputation-free survival, wound healing)

Eligibility criteria:
inclusion criteria: * presence of end-stage renal disease * presence of critical limb ischemia (ankle-brachial-index \> 0.4 or presence of rest pain or ischemic ulcers or gangrene) * revascularisation by means of bypass or endovascular therapy exclusion criteria: * conservative treatment * non-atherosclerotic lesions * coagulation disorders

Keywords: end-stage renal disease critical limb ischemia surgical revascularisation endovascular therapy
integrating metabolic and vascular sensors to monitor cardiometabolic disorders after nutrition interventions

Conditions: NAFLD (Nonalcoholic Fatty Liver Disease)

Summary: it is a 12-week study. the participants will follow three different diets, and during each diet period, and the participants will wear our device, and blood samples will be collected.

the investigators will conduct a randomized, controlled crossover intervention study. the investigators will enroll 54 participants, aged \>18 years, bmi \>25 kg/m2 with metabolic syndrome. during the first phase, all participants will consume their habitual diet for 2 weeks to establish baseline. then participants will be randomized to either a mediterranean diet (med), high-fat/low carb diet (hf/lc), or low-fat diet (lf) for 14 days with 2 weeks washout between the different diets. the wearable system will monitor basal levels and the changes for glucose, cholesterol, tg, and no through sweat analysis and hr, hrv, and pwv for carotid arterial stiffness during each diet intervention.

Eligibility criteria:
inclusion criteria: * united states veterans * male or female, age 18-55 years at the time of signing informed consent. * at least 2 of the following: waist circumference \> 40" for men and 35" for women, fbs \>100 mg/dl, triglycerides \> 150 but \ 120/80 mmhg but \<150/90 mmhg) exclusion criteria: * history of diabetes require medications * history of alcohol intake ≥ 20g/day * history of cirrhosis * renal impairment measured as estimated glomerular filtration rate (egfr) value of \<30 ml/min/1.73 m2 * history of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months. history of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable. * any unstable medical conditions or terminal diagnosis. * any participant who is unwilling to sign an informed consent form will not be admitted into the study.

Keywords: nafld metabolic responses mixed meal challenge
health promotion of people with disabilities

Conditions: Rheumatoid and Osteoarthritis

Summary: this research is meant to evaluate the effectiveness of two different prevention programs for post-acute management of rheumatoid and osteo-arthritis

park nicollet clinic and the institute for clinical systems integration (icsi) have developed evidence-based care guidelines and intervention strategies including degenerative joint disease. included in these guidelines are risk factors for increased limitations, obesity and physical activity. the aims of this research are to modify well-established weight management techniques and physical activity promotion interventions according to icsi recommendations, implement the interventions in a diverse patient population, demonstrate the short and long term impact of the interventions. the approach will be an individual randomized controlled trial of 400 patients, 200 each in a coach-supported intervention, 200 in a self-directed intervention.

Eligibility criteria:
inclusion criteria: * clinical visit 11/1/2003 to april 30/2004 diagnosis code rheumatoid arthritis or lower extremity osteoarthritis saw a provider that consented to have patients invited to participate consented to being contacted for research exclusion criteria: -
a 4-arm clinical trial of fuse®, endocuff™, endorings™ and standard colonoscopy

Conditions: Colorectal Neoplasms

Summary: adenoma detection rate (adr) is a validated marker for reducing the risk of interval colorectal cancer after a screening colonoscopy. recent studies suggest that novel devices attached to the colonoscope tip may improve the adr of doctors performing a screening procedure

recent studies indicate that continuing medical education, time of colonoscopy during the day, forced longer withdrawal time, use of high definition colonoscopes all result in improving adr although the gains have only been modest. to this end, adding novel devices to the tip of colonoscope may improve the ability of doctors to perform a better procedure. we therefore propose to identify the increase in adr with 3 of these devices compared to standard colonoscopy. fuse colonoscopy (2 cameras embedded at the side of the colonoscope tip providing an increased angle of view), endocuff (a plastic cap to fit the tip with flexible arms which hold the mucosa back aiding in inspection), endorings (similar to endocuff but the arms are wider) have been shown in tandem colonoscopy studies to improve the adenoma miss rates to 7-15% instead of the miss rates seen with standard colonoscopy which is usually about 40%. all these devices are fda approved and are distributed in the united states.

Eligibility criteria:
inclusion criteria: * screening or surveillance colonoscopy exclusion criteria: * personal history of colorectal cancer or inflammatory bowel disease * surgical resection of the colon or known colonic stricture * personal or family history of polyposis syndromes or lynch syndrome * referral for incomplete colonoscopy or known therapeutic polyp clearance * severe diverticular disease * referral for a positive hemoccult test in the past 6 months * known coagulopathy * inability to provide informed consent
effects on re-endothelialisation with bydureon treatment in type 2 diabetes subjects

Conditions: Atherosclerosis; Diabetes; Restenosis

Summary: the aim of the study is to use exenatide long-acting release (lar) \[bydureon\] to minimize vascular remodeling and neointima formation after percutaneous coronary intervention (pci) and to accelerate stent endothelialisation.

exenatide lar will be given as a once-weekly (s.c.) dose of bydureon (2 mg) add on to insulin in combination with metformin. if patients are insulin naïve (both groups) an initial dose of 10u (s.c.) at bedtime will be started, and further up-titrated to achieve a fp-glucose levels at 6 mmol/l. standard care for post myocardial infarction will be given after pci. primary objectives: to test whether bydureon, add on to insulin neutral protamine hagedorn (nph) + metformin, is superior vs. insulin nph + metformin alone, in covered stent struts secondary objectives: to test whether bydureon, add on to insulin nph + metformin, is superior vs. insulin nph + metformin alone: in cardiac and endothelial functions

Eligibility criteria:
inclusion criteria: 1. patients eligible for pci with application of des, due to acs. 2. patients with known or newly diagnosed t2d (type 2 diabetes is diagnosed according to current who criteria or by the use of anti-diabetic drugs) 3. male and female subjects 18-80 years. 4. hba1c (accordingly to ifcc) 47 mmol/mol - 110 mmol/mol. 5. signed informed consent form. exclusion criteria: 1. type 1 diabetes (autoantibody positive). 2. any history of receiving glp-1 analogues or dipeptidyl peptidase inhibitors within 6 months 3. known severe heart failure, classified as nyha 4. 4. active myocarditis; malfunctioning artificial heart valve. 5. history of ventricular tachycardia within 3 months before study entry; second- or third-degree atrioventricular block. 6. supine systolic blood pressure \ 200 mm hg at screening. 7. primary renal impairment, creatinine clearance \< 45 ml/min if treated with metformin. 8. uncorrected hypokalemia or hyperkalemia (potassium \ 5.5 mmol/l). 9. significant anemia (hb \< 90 g/l) 10. severe gastrointestinal disease, including gastroparesis. as judged by the investigator. 11. body mass index (bmi) \> 45 kg/m2. 12. malignant neoplasm requiring chemotherapy, surgery, radiation or palliative therapy in the previous 5 years. patients with intraepithelial squamous cell carcinoma of the skin treated with topical 5fu and subjects with basal cell skin cancer are allowed to enter the trial. 13. females of child bearing potential who are pregnant, breast-feeding or intend to become pregnant. 14. current drug and alcohol abuse. 15. history of acute or chronic pancreatitis 16. subjects considered by the investigator to be unsuitable for the study.

Keywords: glucagon-like peptide-1 endothelialization cardiac function exenatide optical coherence tomography
the effect of acupressure on labor pain and anxiety levels during labor in primiparas women

Conditions: Labor Pain

Summary: the effect of acupressure on labor pain and anxiety levels during labor in primiparas women


Eligibility criteria:
inclusion criteria: * primiparas women aged from 20 to 30 years old, * gestational age of between 37 and 40 weeks according to ultrasonography. * a fetal weight of between 2500 and 3500 g according to ultrasonography or clinical examination . * they are transferred to labor room if active labor is in progress (defined as cervical dilatation 3 cm and the presence of regular uterine contraction, * having a single and healthy fetus in the vertex position exclusion criteria: * who were needing an emergency c-section. * women having a current or previous high-risk pregnancy * who have experienced pregnancy complications * women with a systemic disease during pregnancy . women with a psychological disorder