Kornimate/medical-research-clean huggingface dataset:
evaluation nutrition education intervention on pulse and cereal mix for complementary food in southern ethiopia

Conditions: Dietary Habits; Health Knowledge, Attitudes, Practices; Wasting

Summary: the overall purpose of the study is to evaluate nutrition education interventions to promote pulse incorporated complementary food to the wider rural community through the government system to improve maternal knowledge, attitude and practice (kap) and nutritional status of young children (6 to 24 months). the hypothesis is that nutrition education improves mothers knowledge, attitude and practice of pulse incorporated complementary food and improves dietary intake of iron and zinc and nutritional status of young children.

only 9% of the population in southern ethiopia consumes pulse and pulse total contribution of the diet is less than 4.9% for women and less than 3.3% for children.young children are at risk of developing malnutrition because of dietary inadequacy. educational interventions can improve feeding practices and growth of young children. the overall purpose of the study is to evaluate nutrition education interventions to promote pulse incorporated complementary food to the wider rural community through the government system to improve maternal knowledge, attitude and practice (kap) and nutritional status of young children (6 to 24 months). the hypothesis is that nutrition education improves mothers knowledge, attitude and practice of pulse incorporated complementary food and improves dietary intake of iron and zinc and nutritional status of young children. before, at midline and end of the intervention we will assess the kap of mothers, dietary intake of iron and zinc and nutritional status of young children. the nutrition education intervention will be given for 9 months. serum ferritin, serum zinc, c-reactive protein and hemoglobin and dietary intake of iron and zinc of young children will be measured at the beginning and ending of the intervention.

Eligibility criteria:
inclusion criteria: * age 6-15 months * apparently healthy * being breastfed at time of recruitment * the mothers are permanent residents of the kebele exclusion criteria: * infant undergoing treatment with supplemental foods for malnutrition
maintain respiratory muscle function and reduce pneumonia risk in cancer patients

Conditions: Cancer

Summary: this research is intended to begin to explore the impact of inspiratory muscle resistance exercise and/or 1,25(oh)2d3 for improving respiratory muscle strength in cancer patients (subjects).


Eligibility criteria:
inclusion criteria: * diagnosis of cancer * renal and hepatic function (creatinine \</= 2 x the institutional upper limit of normal; bilirubin \</= 2 x the institutional upper limit of normal) * no contraindication to receive either of the planned interventions of inspiratory resistance training or 1,25(oh)2d3 in the opinion of the healthcare provider * no difficulties with swallowing oral medications in the opinion of the enrolling physician exclusion criteria: * patient is taking calcium or vitamin d supplements and is unwilling to stop for 8 weeks * severe chronic obstructive pulmonary disease (oxygen dependent or patient self-reports unable to walk one block without difficulty) * calcium or phosphorus level above the institutional upper limit of normal

Keywords: pneumonia
predictors of success following bariatric surgery

Conditions: Focus of Study is Patient Responses to an Obesity Management Questionnaire Administered by SGH Life Centre

Summary: this study aims to consolidate the contributions of various medical, social and psychological predictors of success following bariatric surgery amongst singaporeans.


Eligibility criteria:
inclusion criteria: * undergone bariatric surgery within sgh life centre and must have completed the intake questionnaire. exclusion criteria: -
use of low cost prostheses to improve upper extremity function in children with cerebral palsy

Conditions: Cerebral Palsy; Prosthesis User

Summary: the purpose of the study is to assess the effectiveness of an upper extremity prosthesis in improving the upper extremity function of children with cerebral palsy who have limited use of their hands. twelve children, aged 4-17 years, who have cerebral palsy and limitations in their ability to use their hands, will be enrolled. all participants will be fitted with a 3d printed arm/hand prosthesis and receive 8 occupational therapy sessions. each subject will be evaluated pre-treatment, post-occupational therapy sessions and at 6 months follow-up. the evaluation will include assessment of (1)passive and active arm/hand movement and (2)functional hand skills using several standardized tests. the results from the pre-treatment and the two post-treatment evaluations will be compared.


Eligibility criteria:
inclusion criteria: * diagnosis: cerebral palsy * 4-17 years old * macs levels iii - v * active movement of wrist or elbow exclusion criteria: * macs levels i, ii * botox or orthopedic surgery in past 6 months * severe contractures * lack of voluntary arm motion
cell therapy in diabetic patients with st-segment elevation myocardial infarction(stemi)

Conditions: Left Ventricular Function Systolic Dysfunction; Left Ventricular Function Diastolic Dysfunction; Death; Myocardial Reperfusion Injury

Summary: the purpose of this study is to investigate the efficacy and mechanism of bone marrow mononuclear cells (bmmnc) transplantation for diabetic and non-diabetic patients with st-segment elevation myocardial infarction (stemi)who have undergone percutaneous coronary intervention (pci).

stem cells are capable of the important properties of self-renewal and differentiation plasticity. human autologous bone marrow mononuclear cells (bmmnc) contain cd34+ haematopoietic and cd34- mesenchymal stem cells. both of these cell types may contribute to heart muscle repair in acute myocardial infarction (ami). in recent years, a variety of clinical trials have explored the hypothesis that bmmnc transplantation may enhance the recovery of left ventricular function after ami. the use of bmmnc is clinically justified and ethically unquestionable because no severe side effects have been reported and immunosuppressive therapy is unnecessary. more over, our previous work showed that patients without diabetes may benefit more from bmmnc transplantation. thus, the aim of the present study was to investigate the efficacy and mechanism of bone marrow mononuclear cells (bmmnc) transplantation for diabetic and non-diabetic patients with st-segment elevation myocardial infarction (stemi)who have undergone pci.

Eligibility criteria:
inclusion criteria: * age between 25 and 60 years old * stemi according to the who definition * pci \<12 hours from the onset of symptoms * lad disease with an open infarct related artery exclusion criteria: * previous myocardial infarction (mi) * cardiomyopathy * atrial fibrillation or flutter * previous heart surgery * severe valvular heart disease * disease of the hematopoietic system * nyha functional class iv heart failure at baseline * severe renal, lung and liver disease * cancer * intra-cardiac thrombus * bone marrow disease

Keywords: bone marrow mononuclear cells; diabetes; st-segment elevation myocardial infarction; percutaneous coronary intervention; left ventricular function
relationship between diabetes and cognitive impairment based on olfactory function assessment and functional mri

Conditions: Diabetes Mellitus; Cognitive Impairment; Obesity

Summary: the purpose of this study is to explore the relationship between diabetes and cognitive impairment by olfactory function assessment and functional mri.

previous research has shown both obesity and diabetes are associated with an increased risk of cognitive impairment. meanwhile, olfactory impairment is associated with incident (amnestic mild cognitive impairment) amci and progression from amci to (alzheimer disease) ad dementia. on one hand, in the cross-sectional study, biometric measurements, cognitive assessment, olfactory function and fmri results are analysed to explore the differences among t1dm patients, t2dm patients and non-diabetic people . one the other hand, in the longitudinal study, changes in olfactory function and fmri results in diabetic and non-diabetic obese patients both at baseline and 6 months after their bariatric surgery are collected to investigate whether better glucose and weight control benefit brain function.

Eligibility criteria:
inclusion criteria: 1. have a certain level of education (at least 6 years), able to complete the cognitive assessment; 2. disease duration \>1 year. exclusion criteria: 1. control participants would be excluded if they had a fasting blood glucose level \>7.0 mmol/l; glucose level\> 7.8 mmol/l after oral glucose tolerance test (ogtt); 2. montreal cognitive assessment (moca,beijing edition) score of \< 20; 3. history of neurologic or psychological illness; 4. history of cardiovascular or cerebrovascular disease; 5. abnormal results of thyroid hormones, vitamin b12, and folate. 6. metal implants, unable to complete the mr examinations or evidence of cortical infarcts, hemorrhage, or structural brain disease other than atrophy, lacunes, or white matter lesions; 7. left-handed; 8. partial or complete olfactory dysfunction associated with sinusitis,allergic rhinitis, and deviated nasal septum.

Keywords: functional mri olfactory function bariatric surgery
a study to learn more about the safety of ultravist in children and in the elderly

Conditions: Hypersensitivity

Summary: ultravist is an iodine-based contrast agent that helps to make medical imaging scans clearer. it is also called iopromide, and it is available for doctors to give patients before they have scans. even after a treatment or substance has been approved for use, researchers continue to study it to learn more about its safety. researchers have done studies on the safety of ultravist, but they want to learn more about specific medical problems called hypersensitivity reactions (hsrs). these are undesirable immune system reactions to the study drug. in this study, the researchers will compare the risk of hsrs in children and in the elderly to the risk of hsrs in middle aged adults. the researchers will look at information about medical problems that happened in people in 4 other studies. these studies are called pms i, image, trust, and ultravist in ct. a total of about 139,000 people will be included in this study. all of the people in the earlier 4 studies received ultravist as an injection into the vein or artery before having a scan. in this study, the researchers will compare the number of children, middle aged adults, and elderly patients who had hsrs after receiving ultravist.


Eligibility criteria:
inclusion criteria: * we included patients of all age groups which were referred to a iodine-based contrast-enhanced procedure of any body part. exclusion criteria: * patients with missing age, sex or who did not receive ultravist 300 or 370 were excluded.
safety and pharmacokinetics (pk) of escalating doses of tiragolumab as a single agent and in combination with atezolizumab and/or other anti-cancer therapies in locally advanced or metastatic tumors

Conditions: Advanced/Metastatic Tumors

Summary: this first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and pk of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incurable tumors for whom standard therapy does not exist, has proven to be ineffective or intolerable, or is considered inappropriate, or for whom a clinical trial of an investigational agent is a recognized standard of care.


Eligibility criteria:
inclusion criteria: * adults 18 years of age or older * eastern cooperative oncology group (ecog) performance status of 0 or 1 * life expectancy at least 12 weeks * adequate hematologic and end organ function * histologic documentation of locally advanced, recurrent, or metastatic incurable malignancy that has progressed after at least one available standard therapy; or for which standard therapy has proven ineffective, intolerable, or considered inappropriate; or for which a clinical trial of an investigational agent is a recognized standard of care * confirmed availability of representative tumor specimens * measurable disease according to recist version 1.1 exclusion criteria: * any anti-cancer therapy, whether investigational or approved, including chemotherapy, hormonal therapy, or radiotherapy, within 3 weeks prior to initiation of study treatment * malignancies other than disease under study within 5 years prior to day 1 of cycle 1 * primary central nervous system (cns) malignancy, or untreated/active cns metastases * leptomeningeal disease * history of idiopathic pulmonary fibrosis, pneumonitis, organizing pneumonia, or evidence of active pneumonitis on screening chest computed tomograph (ct) scan * history of autoimmune disease * positive human immunodeficiency virus (hiv) test * active hepatitis b or c, or tuberculosis * severe infection within 4 weeks prior to randomization * prior allogeneic bone marrow or solid organ transplant * significant cardiovascular disease * known clinically significant liver disease
the number of blastocysts formed in the outcome of freeze all strategy: comffeti trial, cumulative delivery rate

Conditions: Pregnancy, Ovarian

Summary: a prospective study of the blastulation rate in the outcome of the freeze all strategy

a prospective study of the blastulation rate in women under the age of 40 years following freeze all strategy, according to amh levels and sperm parameters. study group 1: number of vitrified blastocysts 0-4 study group 2: number of vitrified blastocysts 5-7 study group 3: number of vitrified blastocysts \>7

Eligibility criteria:
inclusion criteria: * primary infertility * age 20-39 years; * body mass index (bmi) 18-29kg/m2; * regular menstrual cycle of 26-35days, * presumed to be ovulatory; * \>1mil/ml spermatozoa; * short antagonist protocol exclusion criteria: * poor responders; * age ≥40; * tese sperm; * pgs cycles; * donor oocytes; * donor sperm

Keywords: blastocyst freeze-all ivf cumulative results cumulative delivery rate
safety and efficacy of autologous stem cell therapy in chronic stroke

Conditions: Cerebrovascular Accident

Summary: the purpose of this study was to study the safety and effect of stem cell therapy on the functional recovery in patients with chronic stroke.


Eligibility criteria:
inclusion criteria: * males and females * above 18 years of age * diagnosed as stroke by clinical and mri findings exclusion criteria: * presence of respiratory distress * presence of acute infections such as human immunodeficient virus/hepatitis b virus/hepatitis c virus * malignancies * acute medical conditions such as respiratory infection, fever * hemoglobin less than 8 * bleeding tendency * bone marrow disorder * left ventricular ejection fraction \< 30% * pregnancy or breastfeeding
fluid biopsy for the diagnosis of lung cancer

Conditions: Lung Carcinoma

Summary: this trial collects and studies blood samples via fluid biopsy for the diagnosis of lung cancer. studying blood samples in the laboratory may help doctors develop a blood test for lung cancer in the future and provide a better way to screen patients for lung cancer.

primary objective: i. to estimate the sensitivity and specificity of the fluid biopsy in establishing a diagnosis of bronchogenic carcinoma. secondary objectives: i. to determine the accuracy of determination of the histologic subtype of bronchogenic lung cancer. ii. to determine the relative contribution of cell based high definition circulating tumor cell assay (hd-ctc) and imaging mass cytometry (imc) and plasma based circulating tumor deoxyribonucleic acid (ctdna) assays in determination of diagnosis and histologic subtype. outline: patients undergo collection of blood samples on day 1 for analysis via high definition (hd)-single cell analysis (sca) fluid biopsy. medical charts of patients are reviewed at 3 months post-biopsy or computed tomography (ct) screening. after completion of study, patients are followed for up to 1 year.

Eligibility criteria:
inclusion criteria: * scheduled to undergo a diagnostic biopsy for possible lung cancer or * completed a diagnostic lung cancer biopsy in the prior 2 weeks and has not yet undergone treatment or * planning or completed in the last 2 weeks a ct lung cancer screen * ability to understand and the willingness to sign a written informed consent exclusion criteria: * patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study * known other solid tumor malignancy other than lung cancer requiring ongoing active treatment
pectoralis nerve block and quality of recovery in mastectomy patients

Conditions: Breast Cancer

Summary: effects of pectoralis nerve block on quality of recovery after breast surgery has been debated. we hypothesized there might exist relevant psychosocial factor or variable of pain sensitivity which would influence on the benefit of nerve block. this study aims to assess effect of pectoralis nerve block on qor-15 score in subgroups stratified by such factors.

study population all of patients will undergo partial mastectomy. 140 patients will be enrolled. intervention pectoralis nerve block will be performed in the block group. psychosocial factor screening pain-detect, hads, eq-5d, phq-15 (somatic symptom), pcs (pain catastrophizing), bfi (big five inventory), ham-a\&d, pressure algometry (pain sensitivity), quantitative sensory test (pinprick) study endpoints quality of recovery (qor)-15 pain visual analogue scale opioid consumption breast cancer pain questionnaire (bcpq)

Eligibility criteria:
inclusion criteria: * patients aged 20 to 80 years who underwent partial mastectomy for breast cancer. exclusion criteria: * patients with a history of previous breast surgery * patients with a history of adverse reactions to local anesthetics * patients with a history of drug addiction * patients with cancer other than breast * patients with chronic pain who require analgesics * history of hospitalization for psychiatric disorders * preoperative pulse oximetry (spo2) \< 95 % * left ventricular ejection fraction \< 40% * moderate or severe hepatic impairment * body mass index over 35 kg/m2 * blood clotting disorders * pregnant/lactating women * inability to understand consent forms and answer research questionnaires due to cognitive impairment * unable to read consent form (eg illiterate, foreigner, etc.) * do not perform axillary lymph node dissection
group cognitive behavioral therapy (cbt) intervention for women with mild to moderate depression

Conditions: Depression; Anxiety

Summary: the purpose of this study is to develop a structured cbt group intervention for women with depression of mild or moderate severity and to pilot a randomized controlled trial to compare this intervention with usual care in socially deprived areas in bristol, incorporating qualitative methods to assess acceptability.


Eligibility criteria:
inclusion criteria: * mild to moderate depression * antidepressant use is also ok exclusion criteria: * able to speak english * abusing drugs or alcohol * using secondary mental health services

Keywords: cognitive behavioral therapy expert patient programme deprived population women
psychological assessment of patients with chest wall deformities

Conditions: Pectus Excavatum; Pectus Carinatum

Summary: the study aims to investigate the most frequent psychological outcomes associated to chest wall deformities and patients' quality of life.

the study aims at providing psychological assessment (body image, self-esteem, overall mental health) and quality of life investigation of adolescents affected by chest wall deformities, in relation to the severity and type of deformity, and patients' age; identifying risk factors for psychological disorders. the following hypotheses were tested: differences between patients with different chest wall deformities regarding body image and mental health were expected; no hypothesis on the possible results concerning the effect of the severity of deformity on each studied variable was formulated, since previous findings are unclear. concerning age, some differences according to different age ranges were expected. regarding risk factors for mental health problems, older age and greater body image dissatisfaction were expected to be significant risk factors for psychological problems; regarding the severity and type of deformity, results of previous studies are unclear or lacking, so no hypothesis was tested; quality of life and self-esteem variables were also tested, as previous studies showed they are significantly related to general well being and mental health in adolescents. adolescents coming at the outpatient clinics for the first evaluation of their chest wall and one of their parents/caregivers were enrolled. after the medical examination, patients meeting inclusion criteria are invited to participate in the study and to be assessed by a trained psychologist who administered them all questionnaires after they expressed their informed consent.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pectus excavatum or pectus carinatum; * age from 12 to 18 years old; * high level of fluency in italian. exclusion criteria: * clinical diagnosis of chronic or acute disease, or presence of other conditions which could significantly influence adolescents' quality of life, mental health, body image and self-esteem; * diagnosis of intellectual disability or other conditions (e.g. low level of fluency in italian) which could hinder questionnaires understanding.

Keywords: pectus excavatum pectus carinatum adolescents psychological assessment quality of life
development of artificial intelligence system for detection and diagnosis of breast lesion using mammography

Conditions: Women With Breast Cancer

Summary: this project aims to establish a comprehensive artificial intelligence system for detecting and qualitative diagnosing breast lesions. mammary images will be used to construct a diagnosis method based on deep learning. the system is proposed to automatically analyze the type of mammary glands, automatically identify and mark all breast lesions on the mammography images, provide the malignancy probability judgment of the lesions, the bi-rads classification and the clinical suggestion, and also automatically generate the structured diagnosis report.

this is a multi-center study.the project contains a retrospective part(3000 samples anticipated) and a prospective part(7000 samples anticipated). in the retrospective part, investigators collected subjects with mammary images to design the deep learning method and construct a detective and diagnostic model for breast lesions. in the prospective part, investigators validate the accuracy of the constructed deep learning method, and established artificial intelligence system focusing on mammary diagnosis. investigators will also explore the application pattern of the artificial intelligence system in clinical practice.

Eligibility criteria:
inclusion criteria: * the x-ray images of the breast were complete * the results of pathological diagnosis or more than 2 years of mammography follow-up were available * subject signs informed consent(this item was only for prospective study cases) exclusion criteria: * there exists pathological diagnosis of breast lesions when receiving mammography * there lacks pathological diagnosis or 2 years of mammography follow-up * subject withdraws(this item was only for prospective study cases)