Kornimate/medical-research-clean huggingface dataset:
incmnsz - rheumatoid arthritis cohort

Conditions: Early Rheumatoid Arthritis; Rheumatoid Arthritis

Summary: identify rheumatoid arthritis patients diagnose within first 12 months since the beginning of the disease related symptoms. initiate proper treatment according to international standards in order to achieve remission/low disease activity status.

* provide an standardized follow up by a multidisciplinary specialized team. * create a biological (blood) bank to develop future research projects. * create a database with the clinical, serologic, radiographic and functional status patients data. * define comorbidities and mortality causes. * begin an educational program to improve patient disease self-knowledge

Eligibility criteria:
inclusion criteria: * patients ≥18 years old * fulfilled acr 1987 classification criteria for ra * disease evolution of \<1 year when first evaluated, and no specific rheumatic diagnosis except for ra. exclusion criteria: * patients with another rheumatic disease, except sjögren syndrome.

Keywords: rheumatoid arthritis mexico early rheumatoid arthritis cohort mexico
efficacy and safety of longshengzhi capsule on functional recovery after acute ischaemic stroke (longan)

Conditions: Ischemic Stroke

Summary: the aim of the study is to determine if longshengzhi capsule is effective and safe in patients with ischemic stroke in comparison to placebo. this trial is a prospective, multicenter, randomized, placebo-controlled, double-blinded, parallel-group, superiority trial.


Eligibility criteria:
inclusion criteria: * acute ischemic stroke patients within 7 days of onset * 18 years of age or older, and gender not limited * nihss score of 4 to 15 exclusion criteria: * secondary stroke caused by a tumor, traumatic brain injury, hematological disease, or other diseases with a confirmed diagnosis * pre-stroke mrs score of more than 1 * known severe liver or kidney dysfunction * known allergies for ingredients in the investigational product * known bleeding diathesis or coagulation disorder * known medical condition likely to limit survival to less than 3 months * pregnant women (clinically evident) or breastfeeding women * participation in any investigational study in the previous 3 months * known dementia, uncontrolled psychiatric problems * any condition that could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study. the judgment is left to the discretion of the investigator

Keywords: ischemic stroke longshengzhi capsule efficacy safety randomized controlled trial
factors associated to success of hepatitis c therapy

Conditions: Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted

Summary: the aim of this study is to evaluate the sustained virologic response (rvs) in hvc patients treated with pegylated-interferon or conventional-interferon and ribavirin, and to investigate the associated factors with rvs, by means of retrospective analysis.

chronic hepatitis c virus(hvc) is a major public-health problem since it presents a long phase of clinical latency which makes its early diagnosis difficult and results in the development of a large number of cases to complications such as cirrhosis, hepatic insufficiency and hepatocarcinoma. in brazil, it is estimated three million estimated cases to 52 thousand reports. the aim of this study is to evaluate the sustained virologic response (rvs) in hvc patients treated with pegylated-interferon or conventional-interferon and ribavirin, and to investigate the associated factors with rvs, by means of retrospective analysis.

Eligibility criteria:
inclusion criteria: * hvc patients that received specific treatment with pegylated-interferon or conventional-interferon, and ribavirin exclusion criteria: * no hvc infection or treatment
outcomes following total knee arthroplasty

Conditions: Osteoarthritis

Summary: the purpose of this investigation is to determine both patient-reported and performance-based outcomes, specifically muscle function and kinematic/kinetic outcomes, between four different surgical total knee prostheses in individuals following tka. change scores will be determined based on patient-reported outcomes, kinematic/kinetic data, knee extension strength/power, static/dynamic balance control, mobility measures and functional performance testing during functional tasks (i.e. walking, ascending/descending stairs, sit-to-stand). after evaluating the pattern of change in lower-extremity function, the investigators will be better prepared to address residual functional impairments and prognostic factors linked to maximal recovery over two years.


Eligibility criteria:
inclusion criteria: * adults \> 40 years of age that are scheduled for primary tka * if they have had a previous tka, it needs to have been performed on the opposite leg at least 3 months prior to the current tka * willing to return for follow-up visits and should be willing and able to be transported from the uoc to the skeletal muscle exercise research facility (smerf), in the department of physical therapy study site for scheduled research follow-up appointments exclusion criteria: * adult with previous additional orthopaedic, neurological, visual or surgical conditions that may affect gait or balance

Keywords: biomechanics primary total knee arthroplasty tka bearings osteoarthritis total knee replacement
impact of transcranial direct current stimulation on language functions in mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to determine if non-invasive electrical brain stimulation can improve word-retrieval in mild cognitive impairment (mci).

previous studies showed that anodal transcranial direct current stimulation (atdcs) can have beneficial effects on word-retrieval in healthy younger and older subjects. the present study aims to extend these findings by assessing whether atdcs can also improve known impairments of word-retrieval in mild cognitive impairment. atdcs will be applied to the left inferior frontal gyrus in a sham controlled cross-over within subjects design. simultaneous functional magnetic resonance imaging (fmri) will assess underlying neural effects of the stimulation.

Eligibility criteria:
inclusion criteria: * right handed * german native speakers * clinical diagnosis of mild cognitive impairment exclusion criteria: * dementia * other current or previous neurological or current psychiatric diseases * alcohol or drug abuse * mri contraindication (e.g., magnetic metal, pacemaker, claustrophobia

Keywords: mci word-retrieval tdcs fmri
pain relief after hiatal hernia repair surgery

Conditions: Shoulder Pain; Hiatal Hernia

Summary: referred shoulder pain (pain felt when the problem is actually in a different location) is very common after laparoscopic (small, narrow cut) hernia surgery. the purpose of this study is to look at the effect of a simple back massager, which can be readily purchased online or in a store, in addition to the use of standard pain medications.


Eligibility criteria:
inclusion criteria: * scheduled for primary hiatal hernia repair * adult 18 years of age or older * undergoing minimally invasive surgical technique exclusion criteria: * recurrent hiatal hernia * children under the age of 18 years * undergoing open or hybrid surgical technique * history of psychiatric disorder or chronic pain * has a post-operative complication (grade \> i on calvien dindo classification) * allergy to standard pain medication regimen (local anesthetics marcaine, lidocaine, and epinephrine; morphine; oxycodone; tylenol)

Keywords: shoulder pain hernia hernia surgery hernia repair hiatal hernia hiatal hernia surgery hiatal hernia repair post surgery pain
the sensitivity of traditional chinese medical diagnostic tools for diabetic retinopathy diabetic retinopathy-a pilot study

Conditions: Diabetic Retinopathy

Summary: diabetic retinopathy (dr) is the leading cause of impaired visual function and blindness in adults. the fundus photographs were examined to detect dr. the dr severity was graded non-proliferative diabetic retinopathy (npdr) and proliferative diabetic retinopathy (pdr) according to the international clinical diabetic retinopathy and diabetic macular edema disease severity scales. the pathogenesis of dr is complex and not fully understood, and platelet aggregation, microvascular damage, microvascular enlargement, leakage, hemorrhage, or obstruction, resulting in retinal hypoxia and retinal neovascularization. traditional chinese medicine (tcm) diagnostic tools are non-invasive and convenient. this study apply tcm diagnostic tools for clinical diseases, providing objective diagnostic data for evaluation to assess the association of blood stasis and dr. furtherly we would evaluate the sensitivity and specificity of tcm diagnostic tools. this study is a prospective cross-sectional study. we enroll participants form the department of chinese medicine, china medical university hospital. in total, 100 participants , composed of 50 of type 2 diabetes and 50 of diabetic retinopathy, whom previously had a retinal examination. we apply tongue diagnosis system, pulse wave analysis, body constitution questionnaires, and nailfold capillaroscopy to assess the differences of tcm diagnosis in dr. this study aims to identify the clinical symptoms of dr with tcm diagnostic tools and investigate the pattern difference and treatment for dr. furtherly, we could design a clinical trial with improving blood circulation to treat or prevent dr, and improve the health status and quality of life in patients with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 dm group were diagnosed with dm based on criteria recommended by the american diabetes association and required to have a fasting plasma glucose of ≥7mmol/l or an hba1c of ≥6.5%, as measured on 2 separate occasions. exclusion criteria: * cancer, active liver disease, current pregnancy, active infection, and cerebrovascular disease

Keywords: diabetic retinopathy, traditional chinese medicine(tcm), diagnositic tools, sensitivity, blood stasis
impact of acute computed tomography on treatment decisions and time to intervention in renal colic

Conditions: Kidney Stone

Summary: this study intend to evaluate the use of acute computed tomography (ct) when acute renal colic, regarding treatment decisions, time to intervention and additional visits to the emergency department

all patients with a diagnosis of urolithiasis at the emergency department in helsingborg was included during one year, 1 july 2019 to 30 june 2020. data regarding size and location of stone, treatment, follow up was extracted from the medical records.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of urolithiasis at the emergency department in helsingborg exclusion criteria: * patients with a locked medical record
remote ischemic preconditioning on brain injury in carotid endarterectomy

Conditions: Brain Injuries; Remote Ischemic Preconditioning

Summary: this is a randomized controlled trial designed to test an intervention (remote ischemic preconditioning) in patients undergoing carotid endarterectomy (cea).remote ischemic preconditioning(ripc) with transient upper limb ischemia/reperfusion is a novel, simple, cost-free,non-pharmacological and non-invasive strategy.the purpose of this study is to evaluate the effects of remote ischaemic preconditioning on perioperative ischaemic injury in patients undergoing carotid endarterectomy compared to control intervention.the outcomes of interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.

remote ischemic preconditioning (ripc) protocol will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a pressure 200mmhg

Eligibility criteria:
inclusion criteria: * patients undergoing carotid endarterectomy * patients aged 55 years to 80 years exclusion criteria: * inability to give informed consent * known deep venous thrombosis (dvt) in arm * pre-existing lymphedema or axillary node dissection both arms * arteriovenous fistula or graft in both arms * left ventricular ejection fraction less than 50% * diagnosis of dementia, intellectual disability, or mental illness including depression, anxiety, or schizophrenia
assessing weight bias among turkish dietitians

Conditions: Weight Bias; Weight Stigma

Summary: the objective of this study was to examine weight bias among turkish dietitians. and to investigate the effect of the patient's weight status on the dietitian's assessment and dietetic practice.

the dietitians were randomly assigned to an online case study with lactose intolerance, with all patient information identical except for the patient's weight and photograph. in one case there was a photograph of a woman with obesity and in the other a woman of normal weight. the objective of the case study was to evaluate how the body weight of a patient who consulted a dietitian for a reason unrelated to the body weight affected professional practices.

Eligibility criteria:
inclusion criteria: * dietitians working in turkiye exclusion criteria: * pregnancy * breastfeeding

Keywords: obesity weight bias weight stigma fat-phobia dietitian
play dough and picture books: reducing anxiety and fear in 3-6-year-olds during nebulizer treatment

Conditions: Nebulizer Therapy

Summary: this randomized controlled trial aims to evaluate the effects of play dough and picture books on physiological parameters, anxiety, and fear levels in children aged 3-6 undergoing nebulizer treatment. the trial will involve two groups: an intervention group engaging with play dough and picture books during treatment and a control group receiving standard care. physiological data, including heart rate and oxygen saturation, will be monitored alongside behavioral assessments of anxiety and fear. this study seeks to determine whether these non-pharmacological interventions can alleviate distress in young children, contributing to more child-friendly treatment approaches in pediatric healthcare.


Eligibility criteria:
inclusion criteria: * being in the 3-6 age group * follow-up in the emergency department with upper or lower respiratory tract disease * application of nebuliser therapy * staying with the parent during the research * to be able to speak and understand turkish * parents' consent to participate in the study exclusion criteria: * having a disease that causes maladaptive behaviours (adhd, autism, etc.) * having a chronic disease affecting the respiratory tract * chronic diseases or serious infections affecting vital signs * implementation of droplet or contact isolation * having a physical disability that will prevent him/her from playing with playdough * having a cognitive disability that prevents reading books

Keywords: nursing care nubulizer therapy pediatric emergency department
adherence to and beliefs on recommendations for behavioral treatment for migraine

Conditions: Migraine

Summary: migraine patients are oftentimes referred for evidence based behavioral therapies to prevent migraine. yet, at follow-up visits, they report not seeing the behavioral therapist. this is a pilot feasibility acceptability study to assess whether motivational interviewing (mi) can be implemented in the headache center setting to help improve initiation and adherence to behavioral therapy for migraine. we will also assess patients' reasons for making/not making the appointment.


Eligibility criteria:
inclusion criteria: * migraine diagnosis age 16+ * english speaking exclusion criteria: * unable to read the questionnaire, no phone number
safety and pharmacokinetics study of amlodipine10mg and candesartan32mg

Conditions: Hypertension

Summary: clinical trial to evalate the pharmacokinetic interactions and safety between single dose of amlodipine10mg and candesartan32mg and combiation dose amlodipine10mg with candesartan32mg in healthy male volunteers.


Eligibility criteria:
inclusion criteria: 1. healthy male, age 20 to 45 2. subject must be willing and able to provide written informed consent to the study. exclusion criteria: 1. history of any significant sickness, liver system, gall bladder system, kidney, nerve system, respiratory system, blood tumor, endocrine system, urinary system, mental disease, muscloskeletal system, immunity system, the ear, nose and throat system and cardiovascular system. 2. history of any significant gastrointestinal system and surgery of gastrointestinal. 3. history of any significant hypersensitivity to amlodipine, candesartan, aspirin, antibiotic. 4. over 10 tobaccos a day. 5. other condition which in the opinion of the investigator preclude endrollment into the study.

Keywords: pharmacokinetics safety male
resolvin d1 in psoriasis before and after narrowband uvb phototherapy

Conditions: Psoriasis

Summary: • assessment of tissue level of resolvin d1 in psoriasis in comparison to its level in healthy controls in order to verify its role in the pathogenesis of psoriasis.


Eligibility criteria:
inclusion criteria: * patients with psoriasis (adults and children above 12years) * both sexes. * new cases or cases not receiving any treatment for at least 3 months ago. exclusion criteria: * any contraindication to phototherapy treatment (e.g. photosensitizing creams or medications, past skin cancer, especially melanoma, etc...) * erythrodermic and pustular psoriasis. * history of autoimmune diseases or other systemic diseases (e.g. alzheimer's disease, fibromyalgia, cystic fibrosis)
characterization of macroprolactinemia

Conditions: Hyperprolactinemia

Summary: the purpose of this study is to clarify the nature of macroprolactin which has recently been highlighted because of the high prevalence and a diagnostic pitfall of hyperprolactinemia. the results of this study are beneficial for the patients to whom unnecessary medications and unnecessary radiological examinations have been performed. we used the remained serum samples taken for routine prolactin determination during the past several years. since the blood was basically taken to examine the causes of hyperprolactinemia and only remained serum samples were used for this study, the ethics committee of kobe city general hospital judged that it was not required to obtain approval number.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of hyperprolactinemia

Keywords: hyperprolactinemia autoantibody
itopride as an adjuvant for bowel preparation in patients with chronic constipation is effective

Conditions: Constipation

Summary: bowel preparation is a major determinant of colonoscopy and colorectal surgery. polyethylene glycol electrolyte solutions (peg-e) are the most commonly used laxatives in china. however, a significant number of patients, especially those constipated patients, failed colonoscopies due to poor bowel cleaning. inadequate preparation may also lead to missed colonic lesions. the study is based on the hypothesis: itopride hydrochloride, a prokinetic agent, its dual role as dopamine d2 receptor antagonism and acetylcho-linesterase inhibition make it an appropriate adjuvant for bowel preparation. it was reported to promote colonic peristalsis, shorten colonic transit time and accelerate propulsion of colonic luminal contents through inhibition of m3 receptor and dopamine d2 receptors in vitro and in vivo. so this study is to determine the efficacy, tolerance and safety of high dose of itopride, when given in different times before administration of peg-e, for colonic preparation in patients with chronic constipation.

colonoscopy is a reliable procedure for the investigation of colonic and distal terminal ileum disease. the diagnostic accuracy of colonoscopy is dependent on visualization of the colonic mucosa; hence an appropriate bowel preparation is essential for the examination. despite multiple lavage were used throughout the years, the suboptimal cleaning level have been reported vary from 10% to more than 20% and up to one-third of incomplete or failed colonoscopies can be ascribed to poor bowel preparation. so it is important for us to search a new regimen for bowel preparation.

Eligibility criteria:
inclusion criteria: * patients suspected colonic disease and suffered from chronic constipation were referred for colonoscopy and enrolled in the study. chronic constipation was diagnosed on the basis of rome iii criteria.suspected colonic disease was deﬁned as: * recent change of bowel habits; * obscure gi bleeding (hemafecia, melena or positive fecal occult blood test); * obscure abdominal pain; * weight loss; * positive ﬁndings in the colon on gi imaging; * serological test referred to colorectal cancer such as cea elevated obviously; * family history of colorectal cancer or adenomatous polyps. exclusion criteria: * usage of prokinetic agents such as itopride, mosapride within 4 weeks and tricyclic antidepressants 8 weeks prior to entering the protocol; * known allergies or other contraindication to peg or itopride; * a history of abdominal surgery or bowel obstruction; * pregnant or lactating; * conditions associated with severe cardiac, hepatic, or renal impairment.

Keywords: bowel preparation constipation polyethylene glycol itopride
obesity doppler in term pregnancy

Conditions: Doppler Measurement of Uterine Artery

Summary: maternal obesity is an epidemic in the developed world like egypt. there are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. as a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. it has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight. umbilical and uterine artery doppler is widely accepted as a useful tool for monitoring high-risk pregnancies. normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. obesity has little impact on uterine vascular changes reflected by the early uterine artery pi. however, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. many studies have examined the relationship between bmi and doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.


Eligibility criteria:
inclusion criteria: 1. singleton pregnancy 2. gestational age ≥ 37 weeks 3. absence of fetal structural abnormalities 4. absence of maternal comorbidities and/or complications. 5. obese women (bmi ≥ 30 kg/m2) \[11\]. 6. normal weight (bmi 18.5-24.9) \[11\]. exclusion criteria: 1. placenta previa 2. women with antepartum hemorrhage. 3. smokers and alcohol consumers 4. preeclampsia 5. diabetes mellitus 6. women need urgent termination of pregnancy.