Kornimate/medical-research-clean huggingface dataset:
re-hospitalisation after transcatheter aortic valve implantation

Conditions: Aortic Valve Disease; Aortic Valve Stenosis

Summary: the goal of this study is to investigate whether patient-tailored follow-up for patients treated with transcatheter aortic valve implantation (tavi) can prevent re-hospitalisation and improve quality of life compared with the standard follow-up program. the rationale of this study is the persistently high rate of re-hospitalisation after tavi, which increases the risk of mortality and diminishes the patient-evaluated quality of life. our hypothesis is that patient-tailored follow-up for patients treated with tavi will reduce the rate of re-hospitalisation after the tavi-procedure and improve quality of life. the primary endpoints are the rate of re-hospitalisation within 90 days of the procedure and quality of life adjusted life years at 90-day follow-up.


Eligibility criteria:
inclusion criteria: * patients who underwent technical successful tavi * residing in denmark * provided written informed consent exclusion criteria: * index admission mortality * index admission conversion to open surgery * age \< 18 years * women of childbearing potential, pregnant or nursing

Keywords: transcatheter aortic valve implantation transcatheter aortic valve replacement aortic valve stenosis
incidence of macular edema in a uveitis population

Conditions: Macular Edema; Non-infectious Uveitis

Summary: macular edema from uveitis is a serious condition that can lead to vision loss. uveitis is an inflammation inside the eye, and macular edema is when fluid builds up in the central part of the retina, called the macula, which is crucial for clear vision. this fluid buildup can blur vision, sometimes severely. managing this condition can be challenging and may require several treatments to reduce the fluid and protect sight. while we know macular edema is a common cause of vision loss in uveitis, there's limited data on how often it affects people in europe


Eligibility criteria:
inclusion criteria: * hospital-admitted patients in the north denmark region with non-infectious uveitis. * both juvenile and adult patients. * diagnosed with non-infectious uveitis by a medical doctor. * patients presenting with unspecific macular edema may be included if medical records indicate uveitis as the cause of the edema. exclusion criteria: * patients incorrectly classified as having uveitis based on their medical records (no confirmed diagnosis of uveitis). * patients with infectious uveitis. * macular edema due to other cause than uveitis will not count as uveitis associated edema

Keywords: epidemiology of uveitis incidence of macular edema in a uveitis population management of macular edema secondary to uveitis uveitis macular edema non infectious uveitis non-infectious uveitis
helicobacter pylori and proton pump inhibitor

Conditions: Helicobacter Infections

Summary: the purpose of this study is to know the distribution of hp in stomach before use of ppi, during use of ppi, and after stop of ppi.

endoscopy and biopsy will be performed to investigate the distrubition of hp before, during, and after using ppi.

Eligibility criteria:
inclusion criteria: 1. patients who are indicated to endoscopic resection due to gastric neoplasm 2. aged between 19 to 65 years 3. informed consent exclusion criteria: 1. previous history of hp eradication 2. previous history of ppi use within 6 months 3. no hp infection

Keywords: stomach neoplasms proton pump inhibitor endoscopic submucosal dissection helicobacter pylori gastritis, atrophic
investigation of the relationship between pain sensitization and diagnostic parameters in carpal tunnel syndrome

Conditions: Central Sensitisation; Carpal Tunnel Syndrome

Summary: the aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (cts). the main questions it aims to answer are: * can threshold values be determined ultrasonographically and electrodiagnostically in patients who develop pain sensitization? * are pressure pain threshold values and central sensitization inventory scores correlated with ultrasonographic and nerve conduction studies of the median nerve?

carpal tunnel syndrome (cts) is the most common nerve entrapment and the main mechanism is compression of the median nerve under the transverse ligament at the wrist level. its incidence varies between 6.3-11.7% in the general population. in cts, neuropathic complaints such as numbness, burning and tingling in the palmar face of the first two fingers, which are the innervation area of the median nerve, and fatigue in the hand are the most common symptoms. however, it has been reported that these complaints in most patients are not limited to the innervation area of the median nerve but also spread to other neighboring areas. this has been found to be associated with the development of central sensitization in cts patients, and extra-median symptoms are suggested to be a clinical marker of pain sensitization. the term central sensitization is explained as an increase in pain sensitivity due to the amplification of neuron-derived signals in the central nervous system.research shows that ongoing damage to the median nerve stimulates neurons located in the central nervous system, advancing the central sensitization process. although the diagnosis of cts is made electrodiagnostically with typical clinical findings, in recent years ultrasound has been frequently used in the diagnosis of cts because it is non-invasive, fast and reliable. cross-sectional area and echogenicity of the median nerve are the most frequently evaluated parameters at the carpal tunnel with ultrasound. studies focus on the clinical relationship of central sensitization in cts, but its relationship with ultrasonographic and electrodiagnostic data is not yet known.based on this, this study aimed to investigate the relationship between pain sensitization and electrodiagnostic and ultrasonographic parameters in patients diagnosed with cts.

Eligibility criteria:
inclusion criteria: * being diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings * agreeing to participate in the study exclusion criteria: * concomitant history of diabetes, systemic inflammatory disease, active infection and malignancy * having a disease with neuropathic pain such as polyneuropathy, radiculopathy,multiple sclerosis * not agreeing to participate in the study * history of surgery due to cts
monitoring response to antiplatelet therapy

Conditions: Coronary Stenosis; Coronary Thrombosis; Angioplasty, Balloon

Summary: antiplatelet therapy plays a key role in the prevention of complications related to coronary angioplasty and stenting (pci) including procedure related myocardial damage. aspirin and clopidogrel are now universally prescribed in patients undergoing these procedures. however, loading and maintenance doses have not been established and variation in individual response is emerging. new tests to assess the effects of these drugs are being developed but have yet to be incorporated into routine clinical practice. we will assess the effects of aspirin and clopidogrel in a consecutive series of patients undergoing angioplasty using new assays which can be carried out at the bedside. we will compare the results with alternative laboratory based tests and look for an association between the results, peri-procedural myocardial necrosis and subsequent cardiovascular events.


Eligibility criteria:
inclusion criteria: patients aged 18-80 undergoing intended pci for conventional indications. informed written consent. exclusion criteria: administration of gpiibiiia therapy prior to pci, oral anticoagulation, ticlopidine, dipyridamole, nsaid therapy, pregnancy, troponin i \>0.2mcg/l on day of procedure, chest pain in the 24 hrs prior to pci. anaemia (hb\ 450 x10\^9/l, personal or family history of bleeding disorder.

Keywords: aspirin clopidogrel balloon angioplasty coronary thrombosis
detection of anaerobes in different clinicalsamples

Conditions: Anaerobic Bacterial Infection

Summary: early detection of anaerobic bacteria to avoid its serious comlications

infections caused by anaerobic bacteria are common and may be serious and life-threatening.obligately anaerobic bacteria do not grow on solid media in room air (0.04% carbon dioxide and 21% oxygen); facultatively anaerobic bacteria can grow in the presence or absence of air. microaerophilic bacteria do not grow at all aerobically or grow poorly, but grow better under 10% carbon dioxide or anaerobically. anaerobic bacteria can be divided into strict anaerobes that can not grow in the presence of more than 0.5% oxygen and moderate anaerobic bacteria that are able of growing between 2 and 8% oxygen. anaerobic bacteria usually do not possess catalase, but some can generate superoxide dismutase which protects them from oxygen. anaerobes are the predominant components of the bacterial flora of normal human skin and mucous membranes, and are therefore a common cause of bacterial infections of endogenous origin. infections due to anaerobic bacteria can evolve all body systems and sites . the predominant ones include: abdominal, pelvic, respiratory, and skin and soft tissues infections. because of their fastidious nature, they are difficult to isolate from infectious sites and are often overlooked. failure to direct therapy against these organisms often leads to clinical failures. their isolation requires appropriate methods of collection, transportation, and cultivation of specimens. treatment of anaerobic bacterial infection is complicated by the slow growth of these organisms, which makes diagnosis in the laboratory possible only after several days, by their often polymicrobial nature and by the growing resistance of anaerobic bacteria to antimicrobial agent. almost all anaerobic infections originate from the patient's own microflora. poor blood supply and tissue necrosis lower the oxidation-reduction potential and favor the growth of anaerobes. any condition that lowers the blood supply to an affected area can predispose to anaerobic infection. therefore, foreign body, malignancy, surgery, edema, shock, traum and vascular disease may predispose to anaerobic infection. previous infection with aerobic or facultative organisms also may make the local tissue conditions more favorable for the growth of anaerobic organisms. the human defense mechanisms also may be impaired by anaerobic conditions .

Eligibility criteria:
inclusion criteria: - patient with infection organism not yet detected exclusion criteria: * patients with infection organism is already detected
analgesic efficacy of transcutaneous electrical nerve stimulation (tens) versus placebo during the first stage of labor

Conditions: Transcutaneous Electric Nerve Stimulation; Labor Pain

Summary: this study seeks to verify the analgesic efficacy of tens during the first stage of labor applying tens parameters that, according to with the evidence, can be effective for this application and discarding the placebo effect according to the methodological recommendations.

tens is a non-pharmacological alternative for pain control during labor. although it's a method that has been used for decades, there is not enough evidence on its efficacy, so it's considered ineffective in the spanish and british guidelines of clinical practice. the present study seeks to verify the analgesic efficacy of tens by applying the electrodes in the spinal nerve roots associated with labor pain and using conventional tens with parameters that, according to the evidence, may be effective for this application.

Eligibility criteria:
inclusion criteria: - women attending routinary fetal monitoring before labor exclusion criteria: * multiparous * scheduled cesarean * implantable cardioverter defibrillator (icd) or pacemaker * epilepsy * fetal malformation * language barrier
a pilot study of renal hypothermia during partial nephrectomy

Conditions: Kidney Neoplasm

Summary: renal hypothermia may preserve renal function in patients who require partial nephrectomy. in preparation for a definitive randomized controlled trial this pilot study will assess feasibility and variance data to be used for sample size estimation


Eligibility criteria:
inclusion criteria: 1. patients presenting with a renal mass deemed amenable to an open partial nephrectomy regardless of stage or histology. 2. bilateral renal function on radiographic imaging. 3. willing to consent to randomization. 4. willing to comply with study protocol. exclusion criteria: 1. anatomically or functionally solitary kidney 2. multiple renal tumours 3. bilateral renal tumours 4. life expectancy \< 3 months as deemed by treating physician 5. age less than 18 years old 6. pregnancy
monitoring exhaled breath to noninvasively detect glycemic events

Conditions: Diabetes; Hyperglycemia; Hypoglycemia

Summary: the purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic compounds in exhaled breath.

a device has been developed for sensing volatile organic compounds (vocs) from human breath. vocs are chemicals in the air that make up scents and smells, and many vocs are endogenously produced inside the human body. trained dogs can smell exhaled breath to determine if someone has diabetes and can even distinguish hypo- or hyperglycemic events (low or high blood sugar). the purpose of this study is to determine if the sensor device can identify hypo- or hyperglycemic events in persons with diabetes through detecting vocs in breath noninvasively. the data obtained from the voc sensor will be compared to the information that is also gathered from a continuous glucose monitor (cgm) to establish correlations between blood glucose and exhaled voc measurements.

Eligibility criteria:
inclusion criteria: * who are diagnosed with type 1 diabetes. * who are between 12-19 years of age. * that utilize a dexcom (g6 or g7) continuous glucose monitoring device. * that have an established working cgm for at least 12 hours (that does not need to be replaced within 24 hours). * that are willing to share their daily cgm data for the study. * that are the only individuals in their household with any type of diabetes diagnosis (type 1 or type 2). * that are willing to return the device within 24-48 hours of study completion. * that are located in indianapolis, in or its suburban areas. exclusion criteria: * that are smokers or use tobacco products or who live with someone who smokes in their vicinity. * that have a condition or abnormality other than type 1 diabetes that in the opinion of the investigator would compromise the safety of the subject or the quality of the data. * that utilize closed-loop diabetes management systems. * that have symptoms or recently been diagnosed with an upper respiratory illness including covid-19. * that themselves or a close family member (living within the same household at the time of the data collection period) is on a "ketogenic diet". * that themselves or a close family member is working in an industry with high and continuous exposure to exogenous vocs. examples of such industries include beauty salons and paint manufacturers. * that are unable or unwilling to cooperate with sample collection.

Keywords: volatile organic compound (voc) electronic nose (e-nose) exhaled breath noninvasive health monitoring
efficacy and safety of cwp-0403 compared to sitagliptin in patients with type 2 diabetes mellitus insufficiently controlled with metformin alone

Conditions: Type 2 Diabetes Mellitus

Summary: this trial is to evaluate the efficacy and safety of cwp-0403 compared to sitagliptin by proving non-inferiority in patients with type 2 diabetes mellitus insufficiently controlled with metformin alone.


Eligibility criteria:
inclusion criteria: * patients who had diagnosed with type 2 dm before 3 months * men and women between the age of ≥ 19 and ≤ 75 years * fpg ≤ 270 mg/dl at screening visit * patients who consent to participate in this trial by written informed consent form exclusion criteria: * type 1 dm or secondary diabetes * subjects who are administrating oral anti-hyperglycemic drugs or have to take a medicine * body mass index \ 40.0kg/m2 * subjects who are assessed to be inappropriate for this trial by investigator

Keywords: cwp-0403 sitagliptin metformin type 2 dm
a direct to patient study in chronic pain

Conditions: Chronic Pain

Summary: to compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.


Eligibility criteria:
key inclusion criteria: * patient is planning to receive or has received a commercially approved interventional medical device therapy/procedure to treat chronic pain, ascertained from self-reporting * age ≥ 22 years at time of eligibility screening, ascertained by self-reported age at time of eligibility screening * proficient in written and spoken english, defined by self-reporting of comfort reading, writing and speaking english key exclusion criteria: * requires a legal representative to sign the icf ascertained from self-reporting

Keywords: chronic pain
estimating volume using lidco

Conditions: Brain Injury; Ischemic Stroke; Hemorrhagic Stroke

Summary: we hypothesize that the stroke volume variation measured using the commercially available lidco monitor provides a reasonable estimate of volume when compared to standard measures. this study will collate data that is already being collected by the bedside nurses.

objective: to compare measurement of stroke volume variance with intake/output measurements, weight, bun/creatnine values, and central venous pressure. design: non-experimental, non-randomized observational comparative study. setting: the sixteen bed neurocritical care unit at duke university hospital. patients: 45 adult (over 18 years) subjects with intracranial pathology who require volume resuscitation. only patients with current lidco monitoring will be considered eligible for inclusion in the study. interventions: this is an observational study. subjects will receive standard-of-care treatment without additional intervention. data analysis: all data will be collected by the principal investigator / study coordinator. personal patient information will be removed (deidentified) from the permanent data collection records to protect patient confidentiality. data collected will be entered into a microsoft excel electronic spreadsheet and will be saved on a usb disk drive to be stored in a locked cabinet in the investigator's office. statistical analysis using sas v9.1, (cary, nc) will be conducted with a level of significance set at .05 (alpha) using standardized comparative analysis techniques.

Eligibility criteria:
inclusion criteria: * admitted to the neurocritical care unit have an arterial line in place already connected to lidco monitor physician order for monitoring intake and output exclusion criteria: * pregnant females

Keywords: stroke brain injury nursing critical care
tbi-prognosis multicenter prospective study

Conditions: Traumatic Brain Injury

Summary: severe traumatic brain injury (tbi) is the leading cause of death and disability among people under 45 years of age and a major public health problem. although management of severe tbi patients has gradually improved with the establishment of intensive care units (icu) and the development of practice guidelines, mortality is still high - ranging from 30 to 50% - with 30% of survivors suffering from severe neurological sequelae such as neurovegetative states. families and medical teams are frequently called upon to determine reasonable and appropriate goals of care for brain injured patients. they may have to consider high intensity of care, but also the withdrawal of life-sustaining therapies in accordance with patient wishes. physicians involved in the care of severe traumatic brain injury have expressed serious concerns about hasty decisions made in the absence of appropriate evidence of unfavourable prognosis. the purpose of the tbi-prognosis study is to develop a prognostic model by using a multimodal approach of different prognostic indicators and their evolution over time in the acute phase of care. the results of this study will provide better objective information that will facilitate the shared-decision making-process with families and relatives.


Eligibility criteria:
inclusion criteria: * adults (≥ 18 years) with severe blunt tbi admitted to the icu * all patients with a gcs ≤ 8 after initial resuscitation exclusion criteria: * anticipated being on mechanical ventilation for \< 48 hour period due to an altered level of consciousness related to the tbi plus another potentially reversible factor (i.e. drugs, substance abuse, excessive sedation, etc.). * solid malignancy with a life expectation \<12 months * liver cirrhosis child c * chronic heart failure (nyha class iv) * end-stage chronic respiratory disease (o2 dependent) * end-stage renal disease (initiated or expectant chronic dialysis or to be expected) * previous neurologic disorder with abnormal findings (such as a mass lesion) on radiological imaging (ct-scan, mri) or electrophysiological tests (eeg, ssep) (such as previous uncontrolled epilepsy, significant stroke, previous or acute concomitant spinal cord injury, etc) * patients with no fixed address will be excluded because of the difficult follow-up * physician refusal

Keywords: traumatic brain injury critically ill patients death head injury tbi-prognosis critical care medicine withdrawal of life sustaining therapy prognosis prognostic evaluation outcome research mortality decision-making
a caregiver-mediated intervention improves the functional ability of home-living chronic stroke patients

Conditions: Stroke

Summary: to examine the feasibility of improving stroke patients' physical functional recovery and social participation through improving caregiver's care capability.

in the hospital, most rehabilitation units are like sheltered workshops and the therapists work with stroke patients in well-designed, but non-home-like, environment to improve the stroke patient's functional ability. after returning home, stroke patients face new challenges and also need to assume more responsibility for daily activities. without continuing rehabilitation training or proper support, the patients can easily fall into a sedentary lifestyle and lead to declines in functional ability.however, providing home-based exercise by therapists directly would increase the health care cost and may not be practical for chronic stroke patients. hence, the objective of the present study was to determine whether a caregiver-mediated, home-based intervention program is effective for improving stroke patients' functional ability and social participation.

Eligibility criteria:
inclusion criteria: 1. \>6 months post first stroke with mild to moderate disability (brunnstrom stage iii-v) 2. no longer undertaking active rehabilitation program(defined as ≤2 times/wk rehabilitation activities) exclusion criteria: 1. recurring strokes 2. mental or cognitive impairment 3. severe orthopedic disability or unstable medical conditions (such as severe rheumatoid arthritis or acute myocardial infarction) 4. caregiver with mental/behavioral disorders

Keywords: chronic stroke patients stroke rehabilitation caregiver caregiver-mediated intervention