Kornimate/medical-research-clean huggingface dataset:
genetic analysis using blood or bone marrow from participants with neuroblastoma or noncancerous conditions

Conditions: Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma

Summary: this laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions. identifying genes related to cancer may help in the study of cancer. it may also help doctors predict who is at risk of developing neuroblastoma.

objectives: i. perform a whole genome scan for association of neuroblastoma with single nucleotide polymorphisms (snp) and snp haplotypes. ii. identify true disease-associated snp alleles using a customized genotyping platform enriched for haplotype analyses in an independent sample set. iii. validate disease-associated snp alleles and haplotypes in a final independent sample set. iv. identify neuroblastoma predisposition genes. outline: this is a multicenter study. participants are stratified according to presence of high-risk disease (yes vs no) and mycn amplification (yes vs no). dna samples are derived from participants' banked blood or uninvolved bone marrow. a whole genome scan of dna samples is employed to identify candidate single nucleotide polymorphisms (snps). the candidate snps are investigated, using a gene-centric haplotyping approach, to identify 10-20 true disease-associated alleles. the disease-associated alleles are again investigated, using a gene-centric haplotyping approach, to validate 5-10 disease-associated snps. snps are then analyzed for heritable predisposition. patients do not receive the results of the genetic testing. a certificate of confidentiality protecting the identity of research participants in this project has been issued by the children's oncology group.

Eligibility criteria:
inclusion criteria: * patient: * diagnosis of neuroblastoma * banked constitutional and genomic dna within cog-anbl00b1 neuroblastoma biology protocol or another cog biology protocol * at least 1.0 ?g of dna available * control (age, race, and gender-matched): * no diagnosis of cancer * may have other conditions, including any of the following: * asthma * inflammatory bowel disease * attention-deficit disorder * obesity
connect to protect partnerships for youth prevention interventions: phase ii

Conditions: HIV Infection

Summary: this is phase ii of a three stage project whose overall goals are to develop viable community-based hiv prevention interventions and to form and maintain the necessary community collaborations to support such adolescent trials network (atn) research activities. this phase will describe specific locations within high-risk areas where youth, ages 12-24, spend time. hiv risk behaviors, social networking patterns and hiv prevalence among youth at these venues will be assessed by administering anonymous computerized interviews to eligible and willing youth. this information will be shared with community partners during scheduled working group meetings.

this is phase ii of a three stage project whose overall goals are to develop viable community-based hiv prevention interventions and to form and maintain the necessary community collaborations to support such atn research activities. during this phase, each atn site will gather additional information within high-risk areas and solicit community partner input to ultimately pinpoint the specific locations where at-risk youths, ages 12-24, may be recruited for interventions. this will be done by the following methods: venues will be identified by hiv+ youth at the atn site by participation in an anonymous computerized interview. site staff will then perform brief venue interviews (bvis) at selected venues to assess the potential yield of youths 12-24 years old. community partners will also provide the site staff with information on known high-risk venues. high-risk venues will further be identified by the results of anonymous computerized interviews and hiv assays obtained from eligible and willing youth participants at the venues. the interviews will gather information on hiv risk behaviors, social networking patterns and hiv prevalence among youths at these venues. this information will be shared with community partners during scheduled working group meetings.

Eligibility criteria:
inclusion criteria: index subjects: * documented hiv-infection * acquisition of hiv after age 9 years * verbal confirmation of 12-24 years of age * verbal report of having engaged in sexual activity (vaginal, anal and/or oral sex) within the past 12 months * ability to understand and willingness to provide informed consent/assent bvi subjects: * youths who appear to be 12-24 years old hiv serosurvey subjects at the venues: * verbal confirmation of 12-24 years of age * verbal report of having engaged in sexual activity (vaginal, anal and/or oral sex) within the past 12 months * ability to understand and willingness to provide informed consent/assent exclusion criteria: * visibly distraught and/or emotionally unstable (i.e. depressive mood, exhibiting manic, suicidal or violent behavior, etc.) * visibly intoxicated or under the influence of psychoactive agents * clinically presents as acutely ill

Keywords: high-risk youth hiv infected youth community mobilization hiv serosurveys
peri-operative inflammaging in the elderly after surgery

Conditions: Aging; Immunology; Postoperative Complications; Surgery

Summary: the population older than 80 years will significantly increase in the near future. older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortality due to post-operative comorbidities. aging and related diseases share immune-related pathomechanisms. during aging, a chronic, low-grade sterile inflammation, called inflamaging, gradually develops. this likely results from low-grade innate immune activation and a functional, epigenomic and transcriptomic reprogramming of immune cells. based on the hypothesis that surgical trauma leads to misplaced or altered self-molecules, which exacerbate inflammation and the postoperative risk for morbidity and mortality in elderly patients. there is increasing evidence that the individual's pre-operative immunobiography determines the susceptibility to peri-operative inflammation and post-operative outcome. current exploratory pilot study will thus perform phenotyping of patients above 80 years undergoing major surgery. participants will be evaluated for acute and long-term outcomes, including all-cause mortality, physical and cognitive function. to assess the individual's immunobiography, participants will be characterised by inflammation biomarkers combined with immunophenotyping, functional assays, and (epi-) genomic analyses before and after surgery. the cognitive impairment will be evaluated by measuring markers of neurodegeneration and neuropsychiatric testing and relate findings to volumetric imaging using high-resolution mri to identify brain changes associated with cognitive decline.


Eligibility criteria:
inclusion criteria: * age ≥ 80 years * elective major surgery defined as knee / hip replacement, spondylodesis (\> 2 levels), gastrectomy, resection of esophagus, liver, pancreas, colon, rectum or lung exclusion criteria: * no informed consent * not able to perform neurocognitive testing * preexisting infection systemic: crp\>100 mg/l, leukos \>12.0 g/l or clinical signs prosthetic joint infection (msis 2011 criteria): pji is present when 1 major criteria exist or 4 out of 6 minor criteria exist major criteria: * 2 positive periprosthetic cultures with phenotypically identical organisms * a sinus tract communicating with the joint minor criteria: * elevated crp and esr * elevated synovial fluid wbc count or ++ change on leukocyte esterase test strip * elevated synovial fluid pmn% * presence of purulence in the affected joint * positive histologic analysis of periprosthetic tissue * a single positive culture * immunosuppression (hiv, glucocorticoids, immunosupressants) * autoimmune diseases * ongoing or recent (\<3 months) chemo/radiotherapy

Keywords: frailty neuro-degenerative disease innate immunity immunphenotyping
heading in football: impact on neural blood biomarkers

Conditions: Head Injury, Minor; Concussion, Mild; CTE - Chronic Traumatic Encephalopathy; Neurodegeneration

Summary: the goal of this observational study is to evaluate the safety of heading in football. we will study the release of biomarkers in blood that reflect microscopic neural damage. the main questions this study aims to answer are: * does participation in a football match lead to a change in biomarkers that reflect microscopic neural damage? * is the dose of exposure during a football match related to the magnitude of change in biomarkers that reflect microscopic neural damage? participants will participate in a regular football match and provide blood samples before and right after the football match. the football match will be recorded on video to count the number of headers of all participants.

the objective of this prospective observational study is to determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting. healthy amateur football players will be recruited to participate in the study. participants will be invited to play a regular football match for investigation purposes. they will provide a blood sample within one hour before the start of the match and a second blood sample within one hour after the match. participants will be asked to provide a third blood sample within 48 hours after participation, but this is not obligatory. the football match will be recorded on video to determine the number of head impacts of all participants. furthermore, participants will wear heart rate sensors and local positioning sensors to determine the internal and external training load and account for the possible confounding effects of exercise on neural blood biomarkers.

Eligibility criteria:
inclusion criteria: * member of the knvb; * 18 years or older; * male * self-reported fitness to play 70-90 minutes (absence of injury). exclusion criteria: * sustained a head injury in the last year; * history or current neurological condition; * regular participation in other contact sports (e.g. rugby, american football, ice hockey, fighting sports); * (former) military personnel with a history of fighting/blast exposure

Keywords: heading soccer head impact blood biomarker neurodegeneration
the relationship between vitamin d, fingernail thickness and bone density

Conditions: Osteoporosis

Summary: vitamin d deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. an unknown number of elderly have vitamin d resistance resulting in a functional vitamin d deficiency state. because there are no simple procedures or blood tests that identify vitamin d resistance, its prevalence and contribution to disability in the elderly is unknown. our inability to screen for this condition precludes our ability to initiate and monitor treatment. previous studies indicate that fingernail thickness correlates with vitamin d status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin d deficiency but also, those with vitamin d resistance. this procedure may also provide a way to monitor an individual's response to treatment. this study is designed to demonstrate the association between fingernail thickness and vitamin d status.


Eligibility criteria:
inclusion criteria: * females 25-75 years of age with no known bone disorders exclusion criteria: * history of vertebral fractures or nonvertebral fractures without trauma * prescription medications for prevention of osteoporosis (including vitamin d other than multivitamin and estrogen) * history of malignancy other than basal cell or squamous cell cancer of the skin * use of steroids or anticonvulsants in the 6 months prior to enrollment

Keywords: vitamin d resistance
pilot study of targeted normoxia in critically ill trauma patients

Conditions: Trauma; Critical Illness; Oxygen Toxicity

Summary: the objective of this study is to conduct an observational pre/post study to evaluate the clinical impact oxygen guideline implementation on oxygen utilization and oxygenation in critically ill trauma patients.

supplemental oxygen is fundamental in caring for critically ill trauma. while the avoidance of hypoxia is vital, the current clinical practice of excessive oxygenation settings is common, and unnecessary, and may even be harmful. an expert panel convened to define optimal oxygenation targets in critically ill trauma patients. the strong consensus was to target normoxia at an oxygen saturation (spo2) range of 90-96% and arterial oxygen (pao2) range of 60-100 mmhg. accordingly, a pilot trial implementation of this consensus will occur for the care of trauma patients. specific aim: this is an observational pre/post study to evaluate the impact of targeted normoxia implementation in optimizing oxygen delivery and oxygenation in critically ill trauma patients. hypotheses: that the clinical efforts to improve adherence to oxygen guidelines will: 1. improve the proportion of time spent with target normoxia thresholds (oxygen saturation spo2 90-96%) by 2. reducing utilization of unnecessary supplementation oxygen 3. without a substantive increase in hypoxic episodes or an adverse impact on clinical outcomes.

Eligibility criteria:
inclusion criteria: * acute injury/trauma * arrival to emergency department exclusion criteria: * \<18 years of age * known prisoners

Keywords: oxygenation hypoxia normoxia hyperoxia trauma critical illness
acupuncture for blunt chest trauma

Conditions: Chest Trauma; Rib Fractures

Summary: introduction: chest blunt trauma accounts in up to 65% of polytrauma patients. in patients with 0-2 rib fracture, the treatment is relatively limited to oral pain killer and breathing exercise. the patients will suffer two weeks of severe pain accompanied with poor sleep and inability to preform simple daily live activities. in this double blind randomized control study, the investigators offer acupuncture as an additional treatment option. methods: the study is a double blind randomized control trial. the study will include the press needle acupuncture (acu) and placebo (con) group. both groups will receive one treatment, following the first visit to the clinic after chest trauma accident.

introduction: chest blunt trauma accounts in up to 65% of polytrauma patients. in patients with 0-2 rib fracture, the treatment is relatively limited to oral pain killer and breathing exercise. the patients will suffer two weeks of severe pain accompanied with poor sleep and inability to preform simple daily live activities. in this double blind randomized control study, the investigators offer acupuncture as an additional treatment option. methods: the study is a double blind randomized control trial. the study goal is to examine the effect of acupuncture on patients with chest trauma. the study will include totally 72 patients and divide them to two group; the press needle acupuncture (acu) and placebo (con) group. both groups will receive one treatment, following the first visit to the clinic after chest trauma accident. follow up time will be 3 months. expected outcome: the results of this study can potentially provide a simple and cost effective provide analgesic solution to blunt chest trauma patients. the study design can serve as supporting evidence for future double blind studies in acupuncture. other information: the study will be conducted in thoracic surgical department and acupuncture department in china medical university hospital, taichung, taiwan. the study is conducted on blunt chest injury patients and is anticipated to have minimum risk for adverse events. enrollment of the patients and data collection will start after march 2020. the study expected completion time will be march 2022. keywords: blunt chest trauma, acupuncture, press tack needle, rib fracture

Eligibility criteria:
inclusion criteria: * age 20-80 year-old * patients have chest trauma described by themselves or medical chart record within one week * injury severity score (iss) is less than 18 points * body mass index(bmi)\<30 exclusion criteria: * sternal fracture * injury severity score (iss) is equal or more than 18 points * history of intercostal nerve injury * history of cardiovascular disease * history of chronic lung disease * significant lung mass or chest deformity noted in the chest plain film

Keywords: blunt chest trauma acupuncture press tack needle rib fracture
assessment of pain, anxiety and efficiency of numbee compared to traditional local anesthetic syringe

Conditions: Dental Phobia; Dental Anxiety; Anesthesia, Local; Needle Phobia

Summary: the study was conducted among a group of dental patients aged (6-8 years old) of both genders to assess the following variables in the needleless interparliamentary anesthesia (numbee) compared to traditional local anesthesia: 1. pain perception. 2. pain related behaviors. 3. dental anxiety 4. anesthetic efficiency. 5. patient acceptance and preference

the prevalent phobia of needles and the associated rise in dental anxiety when using the traditional needle method of la infiltration, the development of needle-free alternatives for local anesthetics became an urgent necessity. the numbee (biodent, simi valley, ca) is a new gadget that promises less pain administration of local anesthetic without the use of a hypodermic needle. it is a tiny metal cannula with a silicone-like covering that is used for intraligmentary injection without penetrating the periodontal ligament. this study was performed due to the lack of sufficient research on numbee and since it meets a number of exceptional criteria, including being able to anesthetize just one tooth without having to do so for the entire alveolar dental nerve and having a needleless design that may be more appealing to children than the distressing appearance of traditional dental syringes.

Eligibility criteria:
inclusion criteria:1. patients with american society of anesthesiologists-1(asa 1) health status (a completely healthy fit patient). 2. not mentally retarded patient. 3. cooperative patient, as determined by a behavioral rating of "positive" or "definitely positive" according to the frankle behavior classification scale. 4. without a history of dental visits. - exclusion criteria: * 1. mentally and medically compromised child. 2. patient on medication that effect on the pain perception. 3. history of allergy to l.a.

Keywords: dental anxiety pain perception anesthetic efficiency
the safety and efficacy of multimodal thermal therapy in the treatment of early-stage invasive breast cancer

Conditions: Breast Cancer Female

Summary: multimodal thermal therapy (mtt), as an initiative integration of cryotherapy and radiofrequency heating, has been applied to treat various solid tumors. however, the feasibility and safety for mtt in the treatment of breast cancer is unknown. this prospective, open-label, single-arm phase ii clinical study aimed to evaluate the efficacy and safety of mtt in the treatment of early-stage invasive breast cancer, and to explore the ablation-induced immune activating response.


Eligibility criteria:
inclusion criteria: 1. female，age 18-80 years. 2. invasive carcinoma confirmed by core biopsy. 3. newly diagnosed breast cancer patients, without neoadjuvant therapy. 4. imaging findings showed an unifocal breast tumor with a maximum diameter of 2 cm, with no distant metastasis, no calcification, no skin or nipple adhesion, and no invasion of chest wall. 5. the functional level of major organs must meet the following requirements: blood routine: neutrophil (anc)≥1.5×10\^9/l; platelet count (plt) ≥ (plt)≥90×10\^9/l; hemoglobin (hb) ≥90g/l; coagulation: international normalized ratio (inr) or prothrombin time (pt) ≤1.5×uln; activated partial thromboplastin time (aptt) ≤1.5×uln. exclusion criteria: 1. tumor involving skin, ulceration, inflammatory breast cancer patients. 2. tumor involving the superficial layer of the skin. 3. kps score \ 2 4. prior radiotherapy or prior use of investigational drugs or other immunosuppressive agents. 5. heart, brain, lung, kidney and other vital organ failure. 6. uncorrectable severe coagulopathy 7. patient is pregnant or lactating 8. poor glycemic control in diabetes 9. patients with foreign body implantation around the tumor (such as breast augmentation injections or prostheses). 10. patients with severe scars on the skin of the treatment area (protruding from the skin surface, width ≥ 1 cm) 11. human immunodeficiency virus (hiv) infection, active hepatitis b (hepatitis b indicates antigen positive and hbv dna ≥ 500 iu/ml), hepatitis c (hepatitis c antibody positive and hcv-rna above the lower limit of detection of the analytical method). 12. concurrent medical conditions that, in the judgment of the investigator, would jeopardize the subject's safety, could confound the study results, or affect the subject's completion of this study.
cetis-i (cera traction improves spine-i)

Conditions: Lumbar Disc Herniation; Degenerative Spinal Stenosis; Spine Traction

Summary: in this clinical trial, equivalence is evaluated by exploratory comparison of changes in x-ray lesions with test group (cerazem master v6) and control group (physical therapy) in patients with intervertebral disc herniation and degenerative stenosis.

the efficacy and safety evaluation are conducted before and after the application of the test device. the investigator shall apply an investigational device once when visiting a suitable subject for one day (arm;traction treatment) or standard physical therapy including temperature application and traction(arm;physical therapy)

Eligibility criteria:
inclusion criteria: * subject who has been diagnosed with intervertebral disc herniation or degenerative stenosis (a person who has been diagnosed in the past or has been diagnosed upon obtaining consent) * adult men and women over 19 years of age * body mass index (bmi) 18.5 over to less than 30 exclusion criteria: * subject with fibromyalgia, dystonia, and epilepsy * subject with sensory impairment * subject with physical irritation-induced skin lesions such as fever and compression (dermatosis, compression urticaria, choline urticaria, fever urticaria, etc.)