Kornimate/medical-research-clean huggingface dataset:
effects of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke

Conditions: Transcranial Magnetic Stimulation

Summary: the purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.

current studies have shown that repetitive transcranial magnetic stimulation can change the excitability of nerve cells, improve intracerebral artery blood supply, and even reduce the degree of neurological impairment in patients with ischemic stroke. the purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years, both sexes; 2. clinically definite diagnosis of acute ischemic stroke; 3. baseline national institute of health stroke scale (nihss) score ≤25; 4. pre-onset modified rankin scale (mrs) score ≤1; 5. randomized and initiated transcranial magnetic stimulation within 1 week of onset; 6. subject or legal representative agreed to the treatment and signed the informed consent. exclusion criteria: 1. presence of a medical condition such as severe cognitive impairment or mental impairment; 2. patients with serious physical diseases or who have had craniocerebral surgery; 3. previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors; 4. pregnancy or breastfeeding; 5. the presence of metal foreign bodies near the stimulation site, such as intracranial metal implants, cochlear implants, built-in pulse generators (brain pacemakers, cardiac pacemakers), etc.; 6. patients who are unable to complete cerebral autoregulation, or bilateral temporal window penetration poorly; 7. life expectancy of ≤3 months or inability to complete the study for other reasons; 8. unwillingness to be followed up or poor treatment compliance; 9. those who are participating in other clinical investigators, or who have participated in other clinical studies within 3 months prior to enrollment, or who have participated in this study; 10. other conditions that the investigators deemed unsuitable for enrollment.
oral corticosteroids versus exercises on treatment of frozen shoulder,

Conditions: Frozen Shoulder

Summary: the purpose of this study is to compare the efficacy of exercise and oral corticosteroids the treatment of a fs.

after being informed about the study, all patients giving written informed and meet the inclusion criteria will be randomized a double blind manner in a 1:1 (participant and investigator) to oral corticosteroids or exercise.

Eligibility criteria:
inclusion criteria: 1. between ages 18-60 years 2. loss of passive motion of the glenohumeral joint greater than 25% or 30 in at least 2 directions (flexion, external rotation, and internal rotation) compared with the contralateral side 3. the pain vas more than 7 (10 in total) exclusion criteria: 1. bilateral frozen shoulder 2. rotator cuff tear 3. previous corticosteroid injection at the affected shoulder within 3 months

Keywords: frozen shoulder adhesive capsulitis corticosteroid exercise
safety and efficacy of paramedic treatment of regular supraventricular tachycardia

Conditions: Supraventricular Tachycardia

Summary: supraventricular tachycardia (svt) is a term describing any rhythm coming from the top half of the heart. although atrial fibrillation is the commonest cardiac arrhythmia, regular svt's are also common. the two commonest regular svt's are atrioventricular (nodal) reentry tachycardias (av(n)rt) and atrial flutter (afl). atrioventricular (nodal) reentry tachycardias (av(n)rt) are common but benign forms of fast heart rhythm. although av(n)rt can cause unpleasant symptoms and are frightening it is not dangerous. if patients present with av(n)rt the accepted and normal treatment for most is to have the fast heart rhythm stopped by either taking a deep breath and straining or by the use of drugs. patients can then be discharged home and have further investigation and treatment as an outpatient. svt can be frightening for the patient but is easy to diagnose and treat. there is high success rate post treatment for this benign condition. this is traditionally done in the local accident and emergency, although patients can sometimes be unnecessarily admitted to hospital overnight. we propose to investigate the safety and efficacy of training paramedics to treat safe forms of av(n)rt at the scene and then giving the patient an information pack which includes a request for a gp referral to a heart rhythm specialist. patients will be randomly allocated after consenting to take part in the study to either get paramedic or accident and emergency department treatment. we will compare these two approaches by telephone follow up of the patients. the costs of the different approaches will be compared by assessing the rate of appropriate investigation and the information given to patients and how they rated their experiences.


Eligibility criteria:
inclusion patients presenting with regular narrow complex tachycardia on 12 lead ecg exclusion age \< 16 years already enrolled in the study or another research study syncope or blackout sinus tachycardia ecg evidence of myocardial infarction broad complex tachycardia a history of illicit drug use within the previous 24 hours a history of structural or ischaemic heart disease inability or unwillingness to give consent pregnancy failure to obtain intravenous access hypotension - defined as a systolic blood pressure of \<100 systolic contraindications to adenosine injection heart transplant patients patients on dipyridamole patients on regular asthma inhalers obvious atrial flutter
a study comparing corticosteroids alone versus corticosteroids and extracorporal photopheresis (ecp) as first-line treatment of standard ii acute graft-versus-host disease

Conditions: Acute-graft-versus-host Disease

Summary: acute graft versus host-disease remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. the incidence of grade ii to iv acute gvhd ranges from 30 to 50% of the patients transplanted. steroids remain the standard first line treatment for acute gvhd. prolonged exposure to steroids is associated to increased risk of infections and of osteoporosis, osteonecrosis and alteration of growth in children. thus, reducing steroid exposure in order to reduce treatment-related morbidity is another important goal in the management of standard risk agvhd. extracoporeal photopheresis (ecp) is active in controlling steroid refractory or dependent acute gvhd. hypothesis: in this study, the team hypothesizes that addition of ecp to first line treatment with 2 mg/kg steroids of standard risk grade ii agvhd can reduce steroid exposure by increasing the probability of 6 month fftf including absence of systemic steroids for chronic gvhd.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years ; * having received an allogeneic stem cell transplantation for any malignant or non-malignant hemopathy and whatever the type of donor and graft. * with grade ii acute gvhd with skin involvement (stage 1-3 skin +/- stage 1 gastro intestinal) in the 3 months following the allogeneic stem cell transplantation * acute gvhd in the first line treatment * validation of the presence of peripheral or central venous access allowing to perform 2 ecp per week during 3 months. in the absence of a pre-existing and adpated central catheter at the time of inclusion, peripheral venous access will be preferred * leucocytes \> 1.5 g/l * platelets \> 30 g/l, haematocrite \> 27% (allowed transfusions) * patient affiliated to a french social security regimen * information consent form signed. exclusion criteria: * acute gvhd of grade i * acute gvhd of grade \> ii * progressive hematologic disease at inclusion * uncontrolled ongoing infection at time of inclusion: bacterial or fungal infections, increasing cmv viral load. * patient with hiv positivity or replicative hbv or hcv infection * contraindications for uvadex / photopheresis / stéroids / posaconazole / heparin * patient with a history of deep venous thrombosis * pregnancy * women of child bearing potentiel not using contaception

Keywords: acute-graft-versus-host disease extracorporal photopheresis
blood parameters as a predictor of fever after percutaneous nephrolithotomy

Conditions: Urinary Tract Infection Bacterial; Nephrolithiasis

Summary: to investigate the relationship between neutrophil count, lymphocyte count, neutrophil-to-lymphocyte count ratio (nlr), and postoperative fever in patients undergoing percutaneous nephrolithotomy (pnl).

percutaneous nephrolithotomy (pnl) is a minimally invasive treatment commonly used for renal calculi. however, the prevalence of postoperative fever is reported to be 16.7%-35%, even with appropriate prophylactic antibiotic therapy and a sterile urine culture. the most probable causes are urinary extravasation and bacteremia. although it is important to postoperatively isolate the causative bacteria, bacterial isolation may not always be possible, and urinary and blood cultures may prove negative. in addition, establishing the etiology of fever could be time-consuming and the techniques involved may generate pseudo-negative results owing to several factors, especially the antibiotics used prophylactically. this can result in a prolonged hospital stay and increased the cost of patient care. the most commonly used parameters for the early diagnosis of bacterial infections, despite their limited use, are c-reactive protein, white blood cell count, and neutrophil count . superior parameters include procalcitonin, pro-adrenomedullin, interleukin (il)-6, and il-8, but their use is limited by their lack of availability in some centers and their higher costs. recently, the ratio of neutrophil count to lymphocyte count (nlr) has been proposed as an effective, simple, and useful biomarker for the early diagnosis of bacterial infections. however, these tests are used after the emergence of fever. as yet, no single parameter has been proposed for predicting postoperative fever in the absence of preoperative factors known to cause fever. the aim of this study was to investigate whether neutrophil count, lymphocyte count, and nlr obtained from routine preoperative blood tests could be used in predicting fever following pnl in patients with no risk factors for infection.

Eligibility criteria:
inclusion criteria: * underwent pnl operation * preoperative white blood cell count between 4,000 and 12,000/µl exclusion criteria: * preoperative urinary system obstruction * proliferation in preoperative and/or postoperative urine culture * preoperative and/or postoperative blood transfusions * a preoperative urinary diversion and/or intervention * the presence of a postoperative residual stone * the presence of malignancy, * the presence of a hematologic disease. * patients with postoperative complications graded as clavien 2 and above

Keywords: fever bacteremia lymphocytes percutaneous nephrolithotomy neutrophil-lymphocyte ratio
ultrasound-guided thermal ablation for papillary thyroid carcinoma

Conditions: Papillary Thyroid Cancer

Summary: to evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma

to evaluate and predict long-term clinical outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma by a multicenter study

Eligibility criteria:
inclusion criteria: 1. patients age between 18 and 80 year old, both sex 2. papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration 3. the largest diameter ≤2.0 cm 4. no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, neck and chest ct 5. follow-up period ≥12 months exclusion criteria: 1. patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy 2. history of neck radiation 3. coagulation disorder, serious heart, respiratory, liver, or renal failure 4. dysfunction of the vocal cord on the opposite side
finger feeding as a method of hmf supplementation after discharge

Conditions: Low-Birth-Weight Infant; Breast Feeding

Summary: human milk fortifier (hmf) is designed to supply additional calories, protein, vitamins and minerals to infants less than 37 weeks gestation or those less than 1500 g at birth. liquid and powder types of hmf are available in the commercial market. usually, one packet of powdered hmf is mixed to 25-50 cc expressed breast milk. fortification of human milk is technically difficult in fully breastfed infants and artificial teats such as bottle feedings are common used. a study reported lower breastfeeding rate in intervention group who used hmf in comparison with control. finger feeding method is associated with a better breastfeeding rate in hospital use. a feasibility study in vienna reports finger feeding method as a way to provide fortification at home was acceptable.we hypothesize that finger feeding is an easy way for hmf supplementation after discharge to increase successful breastfeeding and improve growth in preterm and or low birth weight infants.

for infants with very low birth weight (\<1500 g) convincing evidence indicates that providing multi-nutrients fortification including protein, long-chain polyunsaturated fatty acid, and micro-nutrients improves infant growth during hospitalization and health outcomes. a study of predominantly breastfed preterm infants with fortification after discharge shows better growth than unsupplemented counterparts at 3 months corrected age. another study showed that post discharged growth of \< 1800 g infants with human milk fortifier (hmf) supplementation until 48 weeks gestational age improved. but without the intensive lactation counselling the breast milk in hmf group were lower than control group if artificial teats were used. 4. finger feeding is an alternative method to feed infants to increase successful breastfeeding, but unpopular in indonesia. study on finger feeding are still limited and most study of them are not randomized trial. we evaluate the method of supplementation on breastfeeding rate, growth and safety. we also do in depth interview with those who have high or low compliance.

Eligibility criteria:
inclusion criteria: * birth weight \< 2500 g * need hmf supplementation after discharge * predominantly breastfed * live in jakarta city and its surrounding * parents agree to follow study procedure with signed informed consent exclusion criteria: * major congenital anomaly or other conditions interfere with normal growth and oral feeding

Keywords: low birth weight infant breast milk supplementation finger feeding
psychosocial consequences of the screening of von hippel lindau diseases for patients operated for a hémangioblastoma of nervous centrasl system

Conditions: Hemangioblastoma (HB) of the Central Nervous System (CNS)

Summary: von hippel-lindau (vhl) disease is a severe autosomal dominant genetic disorder (with almost complete penetrance) that predisposes to many tumors including some associated with a poorer outcome. clear cell renal cell carcinoma (ccrcc) is the leading cause of mortality. the diagnosis of vhl disease may be challenging because tumors have an asynchronous and multi-organ development and there is often no apparent hereditary context. as it is admitted that vhl disease is underdiagnosed, some countries have decided to recall patients presenting one of the potentially vhl disease-associated tumors to screen them for vhl mutation. screening is currently recommended in guidelines but many patients may have not been previously screened. hemangioblastoma (hb) of the central nervous system (cns) is one of the typical vhl tumors and up to 20% of patients with hb show vhl mutation. vhl diagnosis in this population enables the diagnosis of other tumor types at an early stage of development since hb is chronologically the second tumor occurring during the vhl disease history. but it raises critical problems and questions: difficult announcement of a potentially severe disease and psychosocial dimension related to inheritance of the disease.


Eligibility criteria:
inclusion criteria: * age \>=18; * surgery for a cns hb in the department of neurosurgery of la timone university hospital since 1999 ; * absence of prior screening for vhl exclusion criteria: * minor, * incorrect french language
transcutaneous electrical nerve stimulation during outpatient endometrial biopsy

Conditions: Endometrial Diseases; Pain, Postoperative

Summary: the purpose of this study is to see whether transcutaneous electrical nerve stimulation (or tens) reduces pain during an endometrial biopsy. a tens unit is an over-the-counter, fda approved device that sends low-level electrical impulses through the skin to reduce the amount of discomfort experienced during procedures. a tens unit is very low-risk and used in a lot of ways, including for chronic pain, after surgery, and during labor. since there is no standard way of managing discomfort during an endometrial biopsy, the investigators think that tens might be helpful. participating in the study may require some additional time in clinic to answer research-related questions. subjects will be asked to answer demographic questions (which will be combined anonymously) before and after the procedure, as well as rate subject's pain at different time points during the procedure. the biggest benefit in participating is that subject's discomfort might be lower during and after the procedure. subjects may not benefit from participating in this study. there is a small risk of a skin reaction from wearing the tens pads.


Eligibility criteria:
inclusion criteria: * at least 18 years old * undergoing an outpatient endometrial biopsy * duke gynecological oncology clinics and general gynecology clinic exclusion criteria: * age younger than 18 years * unable to follow study instructions and/or independently adjust tens settings * cutaneous damage at the tens application site * pacemaker or automatic implanted cardiac defibrillator * inability to understand or declines to sign the informed consent form * previous personal experience using a tens unit * pregnant women (will be excluded as part of standard of care for endometrial evaluation)

Keywords: endometrial biopsy transcutaneous electrical nerve stimulation
efficiency of electronic multimedia intervention with the cardiac implantable electronic device.

Conditions: Cardiac Implantable Electronic Device

Summary: in this study, we aim to design a multi-media model through e-book for preoperative care of cied intervention, which can enhance the knowledges of patients, reducing the stresses and uncertainties before the intervention. therefore, patient may reduce the psychological internalization after cied intervention, also needs to track the impact of emotional depression, psychological adaption and life quality status.

arrhythmia is defined an abnormality in the heart transmission system related to heartbeat or heart rhythm problem (li et al., 2017). most of arrhythmia could diagnosed and treated effectively, including medication, cardiac implantable electronic device (cied) and operation. many patients have uncertainty about the implantation process, the results and possible complications after cied, the lack of understanding about further progress of their disease, the change of lifestyle and the accident of electronic shock. those causes are the physical and mental negative impacts on patient which makes anxiety or depressed and turn affects the quality of life. at present, there are few clinical models for cied utilizing electronic multi-media in taiwan. the use of multi-media models may integrate clinical care and health education for helping patients to learn disease and care, also through vivid video and multi-media, we may make a clear education of disease causes, treatment and relevant care knowledges which are alleviate the uncertainty factors from patients (hsueh et al., 2016). therefore, the more overall understanding before cied intervention, the more helpful to quality of living and psychological adjustment of the patient. in this study, we aim to design a multi-media model through e-book for preoperative care of cied intervention, which can enhance the knowledges of patients, reducing the stresses and uncertainties before the intervention. therefore, patient may reduce the psychological internalization after cied intervention, also needs to track the impact of emotional depression, psychological adaption and life quality status. keywords：cardiac implantable electronic device、arrhythmia、electronic multimedia、quality of life、psychological adjustment、depression

Eligibility criteria:
inclusion criteria: 1. actual age \> 20 years-old adults. 2. patients are willing to participate in this research. 3. conscious clear, sanity, and be able to communicate with others in mandarin or taiwanese languages. 4. be able to operate mobile electronic device, such as mobile phone, ipad or laptop; families and healthcare provider allows to assist. exclusion criteria: 1. tds \> score 19 (severely depressed patient) 2. patient of terminal stage cancer. 3. patient with delirium during hospitalization.

Keywords: cardiac implantable electronic device quality of life electronic multimedia psychological adjustment
a study of spoken language in mania

Conditions: Manic Episode; Bipolar I Disorder

Summary: this research is being done to find if there are changes with voice and speech during episodes of mania.


Eligibility criteria:
inclusion criteria: * provision of informed consent before any study procedures are performed * english speaker * documented clinical diagnosis for bipolar i disorder * undergoing hospitalization, or boarding in the emergency department, for mania as determined by primary clinical staff exclusion criteria: * positive urine drug screen for amphetamines or cocaine. * expressing paranoid delusions regarding electronic surveillance. * documented clinical diagnosis of developmental delay. * currently involuntarily hospitalized. * deemed at risk for aggression. * failure to comprehend study objectives via comprehension questionnaire. * individuals who have a guardian and are unable to consent for themselves. * current communicable disease requiring isolation.
condylar inclination recorded with modjaw® device.

Conditions: Temporomandibular Disorder

Summary: in oral rehabilitation, the integration into the digital flow of mandibular movements and the patient's individual reference planes optimizes the functional adaptation of prosthetic elements whose design is computer aided. the innovative modjaw® device allows you to record and then virtually simulate mandibular movements. this retrospective study aims to: 1) test the reliability of the modjaw® device; 2) measure the condylar displacements of asymptomatic subjects for the arbitrary programming of simulators. kinematic recordings of 22 healthy volunteers (15f / 7h; mean age: 22.2 years) were analyzed. two recording sessions were carried out within one month of each other, by three different operators; each subject was followed by the same operator during the first (e1) and the second (e2) recording. the values of sagittal condylar inclination (sci) obtained in opening, protrusion, right-left mediotrusion were calculated at 3 and 5 mm of condylar displacement. the transverse condylar inclination (tci) was calculated at 4mm.


Eligibility criteria:
inclusion criteria : adult ; exclusion criteria : temporomandibular disorders (tmd symptom questionnaire)