Kornimate/medical-research-clean huggingface dataset:
non-disabling ischemic cerebrovascular event with apathy

Conditions: Apathy; Minor Stroke; Transient Ischemic Attack; Stroke

Summary: the burden of non-disabling ischemic cerebrovascular events (nice) is significantly increased. however, few previous studies have focused on affective impairment after transient ischemic attack (tia) and minor stroke. stroke survivors are often described as apathetic. even though post-stroke apathy (psa) affects one in three stroke patients,it has not hitherto received much attention. nice-a is a prospective study aimed to explore the association between baseline apathy and probable incident stroke in a population-based sample of tia and minor stroke adults.

transient ischemic attack (tia) and acute minor ischemic stroke, are common and may leave impermanent or mild neurological deficit, they are termed as non-disabling ischemic cerebrovascular disease (nice). tia and minor stroke exhibit the common substantial risk factors for early stroke recurrence and epidemiological characteristic, with approximately 10 to 20% of patients having a stroke within 3 months after the index event. previous studies has shown that post-stroke apathy (psa) affects one in three stroke patients, which is consistently associated with a worse level of functional recovery, poorer overall health and poorer quality of life. however, still little is known about the development of tia and minor stroke patients with apathy. thus, it is imperative to find the relationships between baseline psa and probable incident stroke in these patients. nice is an attractive researching area globally. according to the large quantities of nice patients in china and the low standardized therapeutic rate, the awareness of tia and minor stroke is largely insufficient. the purpose of the present nice-a study is to establish the prevalence, predictors and evolution of symptoms of psa in tia and minor stroke patients during the first post-stroke year.

Eligibility criteria:
inclusion criteria: ≥18 years old onset of a minor stroke (national institute of health stroke scale, nihss≤3) and tia elapsed time from last episode to registry \<1 month exclusion criteria: patients who refused to participate in the research, and patients who failed to complete the follow-up protocol. patients with malignant tumors, or patients with severe liver or kidney disease, whose life expectancy is less than 1 year. patients who received endovascular or thrombolytic therapy.

Keywords: apathy minor stroke transient ischemic attack stroke
welchol as monotherapy for type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the current study investigates welchol as monotherapy to improve glycemic control in subjects with type 2 diabetes mellitus not adequately controlled with diet and exercise alone. the study will evaluate if welchol monotherapy for type 2 diabetes mellitus will be safe, well tolerated and efficacious.


Eligibility criteria:
inclusion criteria: * male or female subjects \>= 18 years of age; * women of childbearing potential (wocbp) must be using an adequate method of contraception as detailed in the protocol. * diagnosis of type 2 diabetes mellitus; * hba1c \>= 7.5% and =\< 9.5 % at screening; * fasting c-peptide \>0.5 ng/ml at screening; * drug naïve (no prior treatment with oad) or having received no pharmacologic therapy for diabetes for the 3 month period prior to screening; * clinically stable in regards to medical conditions other than type 2 diabetes; * concomitant medications must be at stable doses for at least 30 days prior to enrollment, and are not anticipated to need adjustment during the study period; and * fasting glucose =\< 240 mg/dl at randomization exclusion criteria: * a history of type 1 diabetes and/or a history of ketoacidosis; * history of bowel obstruction; * history of hypertriglyceridemia-induced pancreatitis; * fasting serum triglyceride concentrations \>500 mg/dl; * history of dysphagia, swallowing disorders, gastroparesis, other gastrointestinal (gi) motility disorders, or major gi surgery; * history of insulin use of \>= 2 weeks duration in the previous 3 months or a total of \> 2 months of insulin therapy at any time prior to screening; * two or more fasting self-monitored blood glucose (smbg) levels \>240 mg/dl during the placebo lead-in period. * previous treatment with a bile acid sequestrant, including welchol within the 3 months prior to screening; * body mass index (bmi) \>40 kg/m2; * weight loss \> 3% in prior 3 months; and * ldl \<60 mg/dl.
interventional trial of vitamin d deficiency in the patients of general departments

Conditions: Vitamin D Deficiency

Summary: the purpose of the study is to examine the vitamin d state of elder patients in therapeutic departments and to compere the treatment during the hospitalization with the out-patient treatment.

today vitamin d is thought to be one of the most important vitamins in the human body. it's made in the skin during the sun expose, so it must be sufficient in so sunny countries as israel. although many old people in our country suffer from vitamin d deficiency which bring them to recurrent falls, osteoporotic fractures and physical disability. this problem is still underestimated by health authorities in different countries. in this study we will examine the vitamin d state of the therapeutic patient older than 65 year including their physical self-estimation, muscle strength measurement and gait-and-balance tests. then, according to the resent studies, we will treat the patients in the interventional group with two large doses of vitamin d during a month. after that we will compere their health and physical state with the patients treated in the out-hospital department. so we will try to find a useful approach to treat the vitamin d deficiency during the hospitalization.

Eligibility criteria:
inclusion criteria: * the patient was admitted to a general department of rambam medical center for any reason from march to may 2008 * the patient is 65 years old or older * the patient is in a good health, based on medical history, physical examination and laboratory screening evaluation. exclusion criteria: * renal failure with creatinine level more then 1.3 mg/dl or nephritic syndrome. * liver disease with transaminase rise three times from normal level. * nephrolithiasis in the last fife years. * primary hyperparathyroidism, hypoparathyroidism or pseudohypoparathyroidism. * advanced cancer. * chronic diarrhea or malabsorption. * granulomatous disease (sarcoidosis, tuberculosis, lymphoma). * patients, who are receiving barbiturates, rifampin, anticonvulsants. * patients, who are receiving digitalis. * patients, who are receiving glucocorticoids for more than two weeks during the study. * advanced dementia.

Keywords: vitamine d state
electrophysiological findings in fibromyalgia patients

Conditions: Fibromyalgia

Summary: fibromyalgia syndrome (fms); it is a chronic condition characterized by widespread body pain, sleep disturbance, fatigue, impaired cognitive functions, and anxiety (1). fms; chronic fatigue syndrome, interstitial cystitis, irritable bowel syndrome, temperomandibular joint dysfunction, myofascial pain, functional dyspepsia, restless leg syndrome and posttraumatic stress disorder are among central sensitization syndromes (2,3).

etiology and pathogenesis in fibromyalgia have not been fully elucidated. many mechanisms contribute to the formation of fms. many evidence has been found for dysfunction of the central and autonomic nervous system, immune system, cytokines, neurotransmitters and hormones, which are thought to play a role in the disease. since increasing systemic inflammation is thought to have a role in the etiopathogenesis of fms, there are increasing numbers of studies focusing on this aspect of fibromyalgia. neutrophil / lymphocyte ratio (nlr) and platelet / lymphocyte ratio (plr) in peripheral blood are simple markers of systemic inflammatory response. another factor thought to have a role in etiopathogenesis is autonomic nervous system dysfunction. it has been found that there is autonomic dysfunction in the sympathetic nervous system in patients with fms. sympathetic skin response measurements are frequently used electrophysiological methods to evaluate the functionality of the sympathetic nervous system, which is a component of the autonomic nervous system. in addition, vitamin d deficiency is common in fms patients. in a study, inadequate vitamin d levels were found in 45% of fibromyalgia patients. when a literature review is performed, it is seen that electrophysiological studies are performed to evaluate autonomic dysfunction in patients with fibromyalgia. no studies were found showing the relationship between vitamin d levels and inflammatory parameters in patients with fibromyalgia and electrophysiological findings. in our study, it was aimed to compare the autonomic dysfunction of fibromyalgia patients with healthy volunteers by electrophysiological evaluation and to investigate the relationship between vitamin d levels and inflammatory parameters in fibromyalgia patients and the data obtained from electrophysiological studies. in this way, we aimed to contribute to a better understanding of the physiopathology of fibromyalgia patients with autonomic dysfunction.

Eligibility criteria:
inclusion criteria: * 18-65 years old to be diagnosed with fms according to the criteria of american college of rheumatology (acr) 2010 confirmed diagnosis of fms according to american college of rheumatology (acr) 2016 criteria exclusion criteria: * presence of acute infection diabetes mellitus b12 deficiency hypothyroidism inflammatory-rheumatological disease presence a history of malignancy major psychiatric disorder dementia, etc. diseases that may cause loss of cognitive functions

Keywords: sympathetic skin response inflammatory parameters autonomic dysfunction autonomic nervous system
systemic evaluation of the etiologies of young adults with non-traumatic out-of-hospital cardiac arrest

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: the goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients. the main questions it aims to answer are: * whether the protocolized classification of cardiac arrest minimizes the proportion of unknown causes and mis-classification in young cardiac arrest patients? * whether the incorporation of genetic tests in the identification protocol of arrest cause helps the recognition of sudden arrhythmic death syndrome in young cardiac arrest patients? participants will be asked to received serial examinations including genetic analysis to explore the cause of cardiac arrest.

out-of-hospital cardiac arrest (ohca) is an important emergency medical issue. although the refinement of resuscitation and post-arrest care improved the survival rate of cardiac arrest patients, the rate of survival-to-discharge is still less than 20%. the utstein templates for cardiac arrest classified the pathogenesis of cardiac arrest into medical (presumed cardiac or unknown, other medical causes); traumatic cause; drug overdose; drowning; electrocution; or asphyxial (external). presumed cardiac caused arrest in pre-hospital setting might turned out to be other cause after series of workup. in recent observational studies, cardiac origin arrests accounted for about 50% of ohca. these patients had better prognosis than patients with non-cardiac causes. identifying and correcting the persistent precipitating pathology is also a crucial element in managing post cardiac arrest syndrome. systemic analysis protocol, including history, electrocardiogram, laboratory exam, imaging studies, cardiac catheterization, toxicology screening, could facilitate the identification of the causes of cardiac arrest and minimize the proportion of unknown causes. in young patients, structural heart diseases and arrhythmias were also the important causes of cardiac origin arrest. genetic tests might aid the recognition of sudden arrhythmic death syndrome in this group. this study aims to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients, and minimized the proportion of unknown causes and mis-classification.

Eligibility criteria:
inclusion criteria: * non-traumatic out-of-hospital cardiac arrest exclusion criteria: * traumatic cardiac arrest * pregnancy
psa digital phenotyping and inflammation drivers study

Conditions: Psoriatic Arthritis; Flare Up, Symptom; Psoriatic Arthritis Aggravated

Summary: the goal of this observational study is to develop and internally validate a machine learning model for detecting flare using a digital biomarker and a machine learning model for predicting flare, in patients with psoriatic arthritis. the main questions it aims to answer are: * in patients with psoriatic arthritis, is a digital biomarker capable of detecting a flare as compared to clinical defined flare by the rheumatologist? * in patients with psoriatic arthritis, what factors trigger a psoriatic arthritis flare ? participants will be requested to: * install app on their phone * use a smartwatch * complete questionnaires * collect biological material


Eligibility criteria:
inclusion criteria: * diagnosed with psa * age 18 years or older and competent * using a smartphone * agree to use smartwatch * good command of the local language exclusion criteria: * less than 18 years of age * incapacitated

Keywords: psoriatic arthritis inflammation digital biomarker flare
shr-1316 combined with chemotherapy and chest radiotherapy in es-sclc

Conditions: Extensive-stage Small Cell Lung Cancer

Summary: this study is a one arm, open, single center phase ii study. the main purpose of this study was to evaluate the tolerance and preliminary efficacy of shr1316 combined with chest radiotherapy after induction therapy.

this is a single-arm, single-center phase ii study. eligible subjects will receive the following treatment regimens: 4\~6 cycles of shr1316 combined with ep/ec (etoposide, 100mg/m2, d1-3, q3w and cisplatin, 75mg/m², d1, q3w or carboplatin, auc=5, d1, q3w). patients with response sequentially received adebrelimab combined with chest radiotherapy based on investigator decision. patients then the maintenance therapy with adebrelimab until disease progression or intolerable aes.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of extensive small cell lung cancer * eastern cooperative oncology group performance status (ps) of 0 to 1 * 18 to 75 years old * the function of vital organs meets the following requirements. wbc ≥ 3.0 × 10\^9/l, anc≥1.5×10\^9/l, plt≥100×10\^9/l, hb≥9g/dl, alt and ast ≤2.5 times uln, tbil ≤1.5 x uln, crea ≤1.5 times uln or ccr≥50ml/min. inr≤1.5 x uln, aptt ≤1.5 x uln * have not received first-line systemic therapy or immunosuppressive therapy for es-sclc * the estimated survival period is more than 8 weeks * with measurable lesion defined by the recist v1.1: previously irradiated lesions may only be considered as measurable disease if disease progression has been unequivocally documented at that site since radiation and the previously irradiated lesion is not the only site of disease; * signed written informed consent prior to study entry exclusion criteria: * active or untreated cns metastases * leptomeningeal diseases * uncontrolled or symptomatic hypercalcemia * active, known or suspected autoimmune diseases * have received any t cell co stimulation or immune checkpoint therapy * corticosteroids (\> 10 mg / day prednisone or equivalent) or other immunosuppressants were used within 14 days before the first dose of study drug. * subjects had active infections. * failing to properly control the clinical symptoms or disease of the heart * patients who have previously received allogeneic bone marrow transplantation or solid organ transplantation * known to be allergic to the study drug or excipients, known to have a serious allergic reaction to any kind of monoclonal antibody; have a history of hypersensitivity to cisplatin or etoposide * according to the researcher's judgment, there are other factors that may lead to the termination of the study

Keywords: shr1316, chemotherapy, radiotherapy
effects of left nostril breathing in young females having cardiovascular hyper reactivity to cold pressor test.

Conditions: Healthy

Summary: the purpose of this study is to evaluate the effects of left nostril breathing in young females having cardiovascular hyper reactivity to cold pressor test.although,limited literature exist regarding hyper reactivity towards stress induced test in our youth and its effective and easy treatment in the form of left nostril breathing which could proves to be beneficial for our youth.

the cold pressor test (cpt) was introduced as a standard incentive for studying the vasomotor response (hines and brown 1932). hyper-reactors were the subjects in his study who responded more strongly to cpt, participants who show hyper reactivity to cold pressor test (i.e. subjects showing 25 mmhg increase in systolic blood pressure along with 20 mmhg increase in diastolic blood pressure).they proposed that these hyper reactive could be candidates for hypertension in the future. increased occurrence of these diseases could be attributed to an asymmetry in sympathetic and parasympathetic stimulation. control or adaptation of breathing or breathing workouts i-e yoga are thought to be beneficial in the treatment of such disease. although yoga techniques proven to be effective in treating stress related disorders but it is time consuming and young population because of their busy routine couldn't be able to take out time for their health related issues. this study introduces very simple exercise in the form of left nostril breathing which decreases sympathetic activity and increases parasympathetic activity. it is inversely proportional to stress induced response of the body, it is very easy to perform and can be done at any time, and if found significantly effective for stress disorder ,it could be used in daily routine by our youth to get themselves prevented from major risk factors of cvd's particularly hypertension. this study will identify participants with a high potential risk of developing hypertension in the future by administering cold pressor test, additionally the effects of left nostril breathing intervention on hyper reactive participants would be observed and if found significant, it would be a major breakthrough in primary prevention of hypertension.

Eligibility criteria:
inclusion criteria: * participants falling in the following category would be recruited into the study: * females age (18-25) years * participants who show hyper reactivity to cold pressor test (i.e subjects showing 25mmhg increase in systolic blood pressure along with 20mmhg increase in diastolic blood pressure) * consenting participants. exclusion criteria: * the participants in the following category would be excluded from the study: * participants on antihypertensive drugs. * participants who are diagnosed with any cardiovascular, renal, hepatic or metabolic disease. * participants having malignant tumor. * participants with nasal blockages, polyps ,raynaud phenomena * females during menstrual cycle, pregnancy or on oral contraceptives.

Keywords: blood pressure cold pressor test heart rate
clinical analysis of recurrence patterns following conjunctival autografts for pterygium surgery

Conditions: Recurrent Pterygium

Summary: this study is conducted to evaluate its morphologic reproliferating patterns in patients with pterygium treated with the excision and conjunctival autograft.

the medical records of 116 eyes of 116 patients with pterygium who had pterygium excision and conjunctival autograft between february 2009 and may 2011 were reviewed. using consecutively recorded photographs, we evaluated preoperative morphologic characteristics and its growth patterns.

Eligibility criteria:
inclusion criteria: * recurrent pterygium * unilateral or bilateral pterygium * both male and female * consenting to participate in study exclusion criteria: * fibrovascular proliferation secondary to injury * severe dry eye syndrome * pseudopterygium * signs of malignancy on pterygium * corneoscleral trauma or corneo-limbal scars
peroneal nerve injury: a 20- year retrospective case series study

Conditions: Traumatic Injury; Peroneal Nerve Injury; Sport Injury

Summary: in a 20-year retrospective study, all skiers and snowboarders with a peroneal nerve injury at the fibular head treated surgically at the department of plastic, reconstructive and aesthetic surgery at the medical university of innsbruck, austria, were included. covering a period from 1999/2000 to 2018/2019.

all data were gained in a clinical routine context, and the study design was retrospective. the work was approved by the local ethics committee of the medical university of innsbruck, innsbruck, austria (ek nr.: 1300/2019). we reviewed medical charts from over a 20-year period, including all patients with a pni after a ski- or snowboard-related accident requiring surgical intervention at the department of plastic, reconstructive and aesthetic surgery of the medical university of innsbruck, austria. we analyzed the demographical data, including age, gender, and citizenship, as well as included variables concerning the winter sport activity (i.e., ski or snowboard, owned or rented, self-inflicted without collision or collision caused by another skier or snowboarder, professional or recreational athlete). we also analyzed the injury itself (i.e., pni as main injury, open or closed, motoric, sensible or both, fracture, muscle injury, complete or incomplete transection), as well as the treatment.

Eligibility criteria:
inclusion criteria: * skiers and snowboarders * treated with a peroneal nerve injury at the fibular head * time frame january 1999 to dicember 2019 exclusion criteria: * different injury mechanism * injury of a different nerve than peroneal nerve

Keywords: ski accident traumatic peroneal nerve injury reconstructive surgery case series