Kornimate/medical-research-clean huggingface dataset:
ffn clinical evaluation in asymptomatic women at high risk for preterm birth

Conditions: Pre-term Birth

Summary: this study is designed to determine if quantitative analysis of fetal fibronectin (ffn) can be used to advance prediction of spontaneous preterm birth (sptb). this will be a prospective observational multi-center study with approximately 15 to 20 us sites, and approximately 1210 subjects evaluating the clinical utility of the rapid ffn 10q system for preterm birth risk assessment. a single ffn specimen will be collected from each subject between 16 weeks, 0 days and 21 weeks, 6 days. the primary and secondary maternal outcome measures will be determined based on the date of delivery and the estimated date of confinement (edc), which will be evaluated in a standardized manner.

hologic has developed a quantitative test to assess the amount of fetal fibronectin (ffn) present in cervicovaginal secretions, and evaluate the clinical utility of the test in assessing spontaneous pre-term bith risk in a high risk population. identifying women at high risk of giving birth prematurely can be challenging. it is believed that higher levels of ffn measured in vaginal fluid suggest a woman is at a greater risk for delivering early. ffn testing is already approved for use in women from weeks 22 to 35 of pregnancy. the goal of this study is to evaluate the benefits of collecting ffn measurements from a vaginal fluid specimen taken during early pregnancy (from 16 weeks to 22 weeks) to assess the risk of pre-term birth.

Eligibility criteria:
inclusion criteria: 1. pregnant women from 16 weeks, 0 days to 21 weeks, 6 days' gestation 2. maternal age ≥18 years of age 3. subject has signed and dated an institutional review board (irb) approved consent form to participate in the study 4. subjects for this study must be at high risk for preterm birth as indicated by at least one of the following: * a previous delivery of a live born singleton between 20 weeks, 0 days and 36 weeks, 6 days due to spontaneous preterm premature labor or preterm rupture of fetal membranes * short cervical length (≤25 mm) determined by transvaginal ultrasound * current twin pregnancy * cervical cerclage in a prior pregnancy * prior cone biopsy * prior leep / lletz exclusion criteria: 1. maternal age under 18 2. suspected or proven rupture of fetal membranes at the time of specimen collection 3. known significant congenital structural or chromosomal fetal anomaly 4. women with moderate or gross bleeding evident on speculum examination 5. women who have had sexual intercourse within 24 hours prior to specimen collection 6. cervical cerclage at time of specimen collection 7. current triplet (or more) pregnancy 8. placenta previa with active bleeding

Keywords: ptb sptb cervical cerclage leep prom short cervix
efficacy and safety of a new botulinum toxin type a for treatment of facial expression lines

Conditions: Wrinkles

Summary: the dermatological treatment for reducing facial wrinkles with injectable drug botulift (botulinum toxin type a - laboratório químico farmacêutico bergamoltd.) has a not inferior activity when compared with botox ® (botulinum toxin - allergan inc.) in clinical trials.

the study will evaluate non-inferiority in clinical improvement in the intensity of expression lines over 16 weeks of drug botulift (laboratório químico farmacêutico bergamo ltd.) compared with botox ® (allergan inc.). so that the homogeneity of the group opted to use in female patients with glabellar wrinkles grade 2 (moderate) and 3 (severe) scale standard facial wrinkles, established by honecker et al. (2003). the first area of the face perceived in mime is the glabellar complex, located in the space between the eyebrows, wrinkles eventually show (almeida et al., 2010). patients will be evaluated at each visit, the doctor principal investigator and digital photos of the glabellar region at maximum contraction and relaxation will be obtained using the apparatus visia (canfield imaging systems, version 4.0.2) for further analysis by random team dermatologists.

Eligibility criteria:
inclusion criteria: * patients who agree with all study procedures and sign for their own free will the tcle; * adult patients were female between 18 and 65 years, regardless of social condition; * between skin phototype i and iv; * with good mental and physical health; * patients who have not been treated with botulinum toxin type a; * patients who agree to abstain from physical activity for a period of 24 hours, previous and subsequent to the initiation of the study; * patients presenting at screening visit, wrinkles in the glabellar region between classes 2 and 3 of table wrinkles pattern classification, which is diagnosed clinically by the dermatologist. exclusion criteria: * patients who are in classes 0 and 1 of the table pattern classification wrinkle; * patients who have disorders or diseases that might interfere with neuromuscular function (myasthenia gravis or lambert-eaton syndrome); * patients being treated with antibiotics (aminoglycosides) and muscle relaxants; * patients with pre-existing conditions such as ptosis or scars in the area to be assessed, as they may endanger the health of the patient and the results of the study; * patients who have made treatments fill in the glabellar region (retinoic acid, collagen); * patients who have been treated in the dermatological peeling úlitmos three months; * patients are using treatments dermacosmetics agents anti age (vitamin c pure retinoids flavanoids acid hyaluronic others) or used past 3 months * patients with known hypersensitivity to any component of the study drug; * pregnant or lactating women;

Keywords: wrinkles, glabellar, facial.
modifications in cardiovascular risk factors when performing physical exercise in hypertensive and dyslipidemic patients

Conditions: Hypertension

Summary: single-center, randomized, parallel-group, controlled, open-label study. the aim of the study was to evaluate the effects of an exercise training program intervention of different intensities (high intensity versus low-moderate intensity) on blood pressure reduction as a complementary strategy in hypertensive individuals being treated with at least one antihypertensive drug.

all participants included in the study were referred by their primary care physicians, who prescribed physical exercise as a healthy lifestyle intervention added to the antihypertensive regimens in the framework of the "activa-murcia program". participants in the hit and lmit groups followed the same physical training program, with the only difference being the intensity of the training. the program included two phases of physical exercise lasting 12 weeks and 16 weeks, respectively, separated by a 7-week rest period, which coincided with a holiday period. the times of both phases were not equal in terms of duration, since it is a community physical exercise program established by the region of murcia, and does not depend on the researchers. the program was developed by graduates in physical activity and sport sciences, who were in charge of teaching the exercises and supervised each training session. participants assigned to the hit and lmit groups were given guidelines to continue physical exercise during the 7-week rest period, while participants in the control group were offered to participate in the program after the study.

Eligibility criteria:
inclusion criteria: * age between 40 and 65 years. * under treatment with at least one antihypertensive drug for hypertension. treatment should have lasted at least 12 months prior to inclusion in the study. * diagnosed with dyslipidemia under pharmacological treatment or with a specific hypercholesterolemia (\> 200 mg/dl) in the past and a cholesterol level at the start of the study greater than 200 mg/dl. * patient in primary prevention. * subjects who do not develop physical exercise scheduled on a weekly basis. * subjects who have given written informed consent to participate in the study. exclusion criteria: * serious or terminal illnesses. * diagnosis of ischemic and/or cerebrovascular heart disease. * presence of chronic diseases that prevent the performance of a physical exercise program or a stress test (disabling arthropathies, chronic moderate/severe pneumopathies, arrhythmias, etc). * severe mental illnesses: psychosis, severe depressive disorder, neurosis. * diabetes mellitus. * presence of absolute or relative contraindications dictated by the american college of sports medicine (acsm, 1995), during the performance of the stress tests. * pregnant or breast-feeding women * inability to understand the informed consent.

Keywords: blood pressure monitoring primary care physical exercises training intensity
improving sun-protective behaviors and skin self-examinations among african americans

Conditions: Skin Carcinoma; Skin Melanoma

Summary: this randomized clinical trial uses an educational brochure and online tutorial program to assess sun-protective behavior and skin self-examination among african americans. skin cancer is very common among african americans, with a disproportionately high mortality rate. providing a brochure and an online educational program about sun-protective behaviors may encourage african americans to take preventative measures against skin cancer, help improve early skin cancer detection, determine how far the disease has spread, and plan the best treatment.

primary objectives: i. to assess whether an educational brochure and online program will increase sun-protective behaviors among african-american patients who present at the general dermatology clinic. secondary objectives: i. to assess whether the educational brochure and online program will improve skills for skin self-examinations among african-american patients who present at the general dermatology clinic. outline: participants are assigned to 1 of 2 arms. arm i: participants receive a skin cancer educational and preventive brochure distributed by the national cancer institute and watch a 30-minute online tutorial video called x-plain about skin cancer, preventative behaviors, and skin self-examinations. arm ii: participants receive an educational brochure as in arm i. after completion of study, participants are followed up at 30 days.

Eligibility criteria:
inclusion criteria: * self-identified african-americans who are literate and fluent in english exclusion criteria: * non-african-americans * english illiteracy * non-fluency in english
mechanisms of ultra-acute hyperglycemia after successful resuscitation from out-of-hospital cardiac arrest

Conditions: Heart Arrest; Cardiac Arrest

Summary: the aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (rosc) in patients suffering out-of-hospital cardiac arrest. the investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (glp-1). two blood samples will be drawn: (1.) immediately after rosc and (2.) 60 minutes after first sample. concentrations of glucose, insulin, glucagon and glp-1 will be compared between the samples. metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.


Eligibility criteria:
inclusion criteria: * age ≥18 years * witnessed cardiac arrest * interval form emergency call to return of spontaneous circulation 10-45 minutes exclusion criteria: * severe pre-arrest disability leading to withdrawing treatment in prehospital phase * no concent from next of kin

Keywords: glucose cardiac arrest resuscitation insulin glp-1
the effect of psychoeducation focused on reducing internalized stigma

Conditions: Schizophrenia; Treatment Adherence; Stigma, Social

Summary: in the fight against stigma, the focus should be on the education of individuals diagnosed with mental illness. psychoeducation has an important place in the treatment and rehabilitation of mental health problems. psychoeducation is necessary for early recognition of signs and symptoms of diseases, ensuring compliance with treatment, improving coping skills, as well as combating stigma, preventing internalized stigma, and counteracting social stigma. if individuals with mental disorders have adequate knowledge about the causes of stigma, they may be less prone to internalized stigma.

the group most exposed to stigma among mental illnesses is individuals diagnosed with schizophrenia. these individuals avoid treatment due to fear of stigma, which creates a significant obstacle to ensuring their well-being. internalization of stigma causes feelings of loneliness, anger, helplessness, deterioration in quality of life, and decrease in self-esteem, while at the same time creating a significant barrier to treatment compliance. compliance problems with treatment: it causes impairments in functionality, relapses and exacerbations, repeated hospitalizations, adverse effects on quality of life and increased mortality rates. the fact that many patients who receive only medical treatment in the treatment of schizophrenia develop negative attitudes towards drug use due to drug side effects and recurrence of disease symptoms reveals that psychosocial approaches should also be given importance in addition to medical treatment. as a result, it is thought that internalized stigma is a significant obstacle to treatment compliance and practices implemented to reduce internalized stigma are effective in increasing treatment compliance.

Eligibility criteria:
inclusion criteria: * volunteer to participate in the research, * diagnosed with schizophrenia according to dsm-v tr diagnostic criteria, * over 18 years old, * being in remission for 2 months, * at least primary school graduate, * residing in edirne city center and its districts, * individuals without hearing or understanding problems. exclusion criteria: * not meeting the inclusion criteria, * having a diagnosis of dementia or other organic mental disorder as an additional diagnosis, * individuals with a history of substance abuse (other than nicotine).

Keywords: schizophrenia treatment adherence internalized stigma psychoeducation
clinical study to assess the efficacy and safety of df277 compared to placebo in the treatment of otic eczema

Conditions: Otic Eczema

Summary: the purpose of this study is to evaluate the safety and efficacy of df277 for the treatment of otic eczema.


Eligibility criteria:
inclusion criteria: * 12 years or older * clinical diagnosis of otic eczema suitable for local treatment exclusion criteria: * other diseases.
comparison of 2 cefazolin prophylactic protocol in laryngectomy patients

Conditions: Laryngeal Cancer

Summary: patients who need major head \& neck surgery are at risk of post operative wound infection. in spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists in the optimal antibiotic regimen

patients undergoing laryngeal oncologic surgery are at relatively high risk of developing complication. efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery was reviewed in many researches \[6\] but considering the costs and morbidities of prolonged antibiotic regimen we have presented a prospective and randomized study in 90 patients comparing the efficacy of 2 day over 5 day protocols.

Eligibility criteria:
inclusion criteria:e. * patients eligible to be included in this trial were those who histologically confirmed squamous cell carcinoma of larynx and hypopharynx and they were candidate of total or partial laryngectomy with or without neck dissection and with negative history of neck or laryngeal radiation were included in this study. exclusion criteria: * patients having recurrences or another primary tumor, and those who underwent reconstruction with a flap were excluded from the study, because they had been submitted to prolonged antibiotic administration. also cases with diabet mellitus and immune suppression or tumor types other than squamous cell carcinoma were excluded from the study. * in addition, the following exclusion criteria were taken into account: pregnancy, hypersensitivity to penicillins or cephalosporins, patients who received a systemic antibiotic drug within one week prior to the planned procedure, those who had clinical or laboratory evidence of a preexisting infection or had serious systemic renal disease.

Keywords: clean contaminated, laryngectomy, wound infection
core stability and respiratory parameters in children with thoracic hyperkyphosis

Conditions: Hyperkyphosis; Respiratory Failure

Summary: hyperkyphosis, defined as an excessive curvature of the thoracic spine beyond normal limits, is among the factors that reduce chest wall mobility and lung function. in modern society, increased sitting durations contribute to increased thoracic kyphosis. studies have indicated that an increase in thoracic kyphosis and a decrease in thoracic spinal mobility are associated with reduced respiratory functions, such as forced vital capacity (fvc) and forced expiratory volume in one second (fev1). the diaphragm forms the upper part of the core stability system. when contracted, it increases intra-abdominal pressure, contributing to core stability. the diaphragm also contracts in advance of and during limb movements to assist in postural control. additionally, the diaphragm is the primary respiratory muscle responsible for inspiration. any functional loss in the diaphragm, which alone accounts for 65-80% of vital capacity, can significantly reduce inspiratory capacity. during forced expiration, muscles such as the rectus abdominis, transversus abdominis, internal obliques, and external obliques play an active role. specifically, the transversus abdominis, like the diaphragm, increases intra-abdominal pressure and supports trunk stabilization. however, the relationship between respiratory muscle strength and the endurance of core stability muscles remains unclear. in light of this information, this study aims to investigate the relationship between the endurance of core muscles, which contribute to trunk stabilization, and respiratory parameters in children with thoracic hyperkyphosis.


Eligibility criteria:
inclusion criteria: * be between the ages of 7 and 18 * have a thoracic kyphosis angle (cobb) of ≥45˚ on a lateral x-ray or a kyphosis index of ≤13 exclusion criteria: * individuals who have undergone major surgery or trauma related to the musculoskeletal system, particularly the spine and upper extremities * difficulty in understanding given instructions * presence of rigid deformity in the spine (scheuermann's kyphosis) * presence of congenital deformities (congenital kyphosis)

Keywords: thoracic hyperkyphosis respiratory function respiratory muscle strength core stability
a post-marketing safety study of dorzagliatin in patients with type 2 diabetes

Conditions: Type2diabetes

Summary: the primary objective of this study is to evaluate the long-term safety of dorzagliatin in a larger population of type 2 diabetes mellitus patients by collecting the post-marketing clinical safety data of dorzagliatin.

this study adopts a multicenter, prospective, and observational cohort study design and does not involve randomization, control, and blinding. patients with type 2 diabetes mellitus who were prescribed dorzagliatin according to the package insert and physician's judgment in routine medical practice setting will be included, and the data of these patients during 52-week dorzagliatin treatment will be collected to evaluate the safety of long-term medication.

Eligibility criteria:
inclusion criteria: - patients must meet all of the following inclusion criteria to be eligible for this study: 1. male or female ≥ 18 years of age at the time of signing the informed consent form; 2. patients with type 2 diabetes mellitus diagnosed at screening; 3. patients who have been prescribed dorzagliatin according to the package insert and physician's judgment (the prescription should be made before enrolling the patient in this study and is independent of the enrollment decision); 4. willingness to participate in the study and sign written informed consent. exclusion criteria: - patients will not be eligible if they meet any of the following criteria: 1. other types of clinically diagnosed diabetes, such as type 1 diabetes or other special types of diabetes; 2. patients who, in the opinion of the investigator, are at risk of allergy or intolerance to any component of dorzagliatin; 3. patients who, in the judgment of the investigator, cannot complete or are not suitable for this study.

Keywords: post-marketing long term safety dorzagliatin
effects of foot strengthening on the incidence of injuries in long distance runners

Conditions: Leg Injuries

Summary: the main objective of this trial is to investigate the effects of a training protocol for the foot and ankle complex on the prevalence of running related injuries on long distance runners.

using a web software as a follow up tool, subjects can be scanned for injuries and have them confirmed by a physician, determining the injuries prevalence in one year. through force platform and infrared cameras, the kinematics and kinetics during gait will allow assessment of joint moments, power during propulsion, ankle and knee range of motion. the hypothesis is that a strengthening program for foot and ankle muscles can alter the prevalence of lower limbs injuries on long distance runners, lowering the harmful forces that these segments receive. the participants will be randomly assigned into control group (placebo intervention) or into intervention group, that will receive an 8 weeks strengthening intervention, twice a week with the supervision of a physiotherapist and three times a week being remotely supervised by a software at home, for 30 minutes each session. this will aim for increasing foot and ankle range of movement and muscle strength. every exercise has its own progression depending on the subjects execution, increasing in intensity and difficulty.

Eligibility criteria:
inclusion criteria: * practice long distance (more than 5 km) running for at least one year; * run at least 20 km a week; exclusion criteria: * run using minimalist shoes or barefoot; * having prior experience in isolated foot and ankle strength training within the last year; * have any health condition that affect gait and running; * being receiving any physical therapy intervention; * having any running related injuries during the last two months.