Kornimate/medical-research-clean huggingface dataset:
long-covid: treatment of cognitive difficulties

Conditions: COVID-19; Cognitive Dysfunction

Summary: the purpose of the study is to explore the potential effectiveness of two common low-dose interventions, one targeting cognitive difficulties and the other targeting affective difficulties on quality of life and cognition in people suffering from long-covid with cognitive complaints.


Eligibility criteria:
inclusion criteria: * subjects able to understand the information and consent forms; * medically stable and at least 3 months after positive pcr for covid-19; * self-reported sufficiently good physical condition to attend the appointment; * no major hearing or vision disorders; * cognitive complaints that place the person in the top 20% of dissatisfied functioning on the brief or mmq questionnaires; * poor objective performance supported by a score below the 20th percentile on one task of the cognitive battery. exclusion criteria: * any chronic or remote neurological disorder (i.e. stroke, head trauma, epilepsy, tumor); * cognitive impairment (minor or major neurocognitive disorder; intellectual disability) preexisting to the covid-19 episode; * acute brain injury or acute encephalopathy from another aetiology than covid (e.g., sepsis, liver or renal failure, alcohol or drug withdrawal, drug toxicity); * documented preexisting history of psychiatric illness, including substance abuse; open-heart cardiac surgery or cardiac arrest during the last 6 months; * current hospitalization; * current revalidation care with cognitive treatment
utility of citogenex administration in patients with colon-rectal cancer

Conditions: Colonic Neoplasms

Summary: the main aim of the present study is to test the efficacy and safety of citogenex administration in patients with colon-rectal cancer.

citogenex is a dietary supplement of insoluble polysaccharides, of lactobacillus casei (specific type) and of bifidobacterium lactis (specific type). these subspecies of probiotics bacteria have been shown to be effective in improving the immunity. several trials are currently underway, in order to evaluate the effects of probiotics as potential novel therapies in addition to traditional therapeutic approaches. although probiotics do not play an anti-tumor action per se, these agents may significantly contribute to decrease the typical side effects due to traditional anti-tumor treatments, such as gastrointestinal symptoms, immunity deficit, as well as the alterations in the gut lymphoid tissue. it is therefore expected that citogenex may have several significant beneficial effects in patients under anti-tumor treatments. in order to test this hypothesis, we will perform a randomized, single-blind, two-arms, prospective study in patients with colon-rectal cancer.

Eligibility criteria:
inclusion criteria: * stage iiia-iiic (ajcc/tnm)
japanese safety study of vegf trap-eye in dme (diabetic macular edema)

Conditions: Macular Edema

Summary: this study will assess the safety and tolerability of intravitreally (ivt) administered vegf trap-eye in japanese subjects with diabetic macular edema (dme) over the period of one year.


Eligibility criteria:
inclusion criteria: * adults ≥ 18 years with type 1 or 2 diabetes mellitus * subjects with dme (diabetic macular edema) secondary to diabetes mellitus involving the center of the macula in the study eye * bcva (best-corrected visual acuity) etdrs (early treatment diabetic retinopathy study) letter score of 73 to 24 (20/40 to 20/320) in the study eye exclusion criteria: * active proliferative diabetic retinopathy (pdr) in the study eye * uncontrolled diabetes mellitus, as defined by hba1c \>12% * only 1 functional eye even if that eye is otherwise eligible for the study

Keywords: diabetic macular edema dme vegf trap-eye best-corrected visual acuity (bcva)
computerized mobilization of the cervical spine utilizing the occiflex device for the treatment of chronic neck pain

Conditions: Neck Pain

Summary: the purpose of this study is to investigate the efficacy and safety of the occiflex device in the treatment of neck pain.


Eligibility criteria:
inclusion criteria: * patients with chronic neck pain: post-whiplash injury, myofacial pain, cervical facet joint disease and idiopathic chronic neck pain exclusion criteria: * radiculopathy * myelopathy * cerebral vascular disease * malignancy * osteoporosis * cervical disc herniation
oral herbal combination formulation and hair growth in women

Conditions: Hair Loss; Hair Thinning

Summary: the purpose of this research is to test the effects of an herbal combination formulation on hair growth in women with self-perceived hair loss.the information from this study may help to better understand how certain herbal supplements can affect hair growth. this may lead to better understanding of the hair, hair loss and help develop naturally-based treatment regimens in the future.


Eligibility criteria:
inclusion criteria: * age 18 and above * subject must be able to read and comprehend study procedures and consent forms. * women with self-perceived hair loss as confirmed by the investigator. * willing to maintain the same hairstyle, hair color, hair length and hair regimen throughout the study period. subjects with color-treated hair will have the color treatment performed at the same time interval prior to each visit (if the color treatment was done 1 week prior to visit 1, it should be repeated 1 week prior to visit 2). * willing to keep diet and exercise routine consistent throughout study exclusion criteria: * subjects should be generally healthy and have no smoking history in the past one year. * subjects must have no history of diabetes, metabolic syndrome, hiv, immune deficiency, autoimmune disease known cardiovascular disease, malignancy, kidney disease, or chronic steroid use. * women who are pregnant, planning to become pregnant or breastfeeding * those who are unable to discontinue medicated shampoos or topical scalp medications for two weeks prior to and during the study. * those who are unable to discontinue supplements containing eclipta alba, emblica officinalis, centella asiatica and hibiscus sabdariffa for one month prior to starting the study * those who have a known allergy to eclipta alba, emblica officinalis, centella asiatica or hibiscus sabdariffa * use of hair regrowth products in the previous 6 months * using or planned use of non-breathable wigs * those with a history of hair transplantation procedure * presence of other dermatological disorders causing alopecia * chemotherapy, radiation therapy or laser therapy (of scalp) in the last 6 months * light therapy in the past 3 months * participants using hormonal birth control unless on a stable / unchanged regimen for at least 3 months. * systemic treatment during the last 3 months before study inclusion that could interfere with the study medications (ie, minoxidil, corticosteroids, aminexil, topical estrogens, ketoconazole, beta blocker, cimetidine, diazoxide, isotretinoin or vitamin a intake \>10,000 iu/d) * use of ocular prostaglandins for less than 4 months before first study visit * those that are prisoners or cognitively impaired
propofol and sevoflurane anesthesia in colorectal cancer surgery: incidence of acute kidney injury

Conditions: Acute Kidney Injury; Cancer Colorectal

Summary: the goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury. the main questions it aims to answer are: * is there a difference in acute kidney injury incidence in the two anesthetic modalities? * is there a difference in plasma creatinine between the two anesthetic modalities? * are there any patient characteristics or intraoperative factors that effect the incidence of acute kidney injury in either anesthetic modality? the study will analyze data from the can clinical trial database. (cancer and anesthesia: survival after radical surgery - a comparison between propofol or sevoflurane anesthesia, nct01975064)


Eligibility criteria:
inclusion criteria: * colorectal surgery and participant in the can trial exclusion criteria: * missing blood samples

Keywords: sevoflurane propofol plasma creatinine
operative versus non-operative management for appendicitis with abscess or phlegmon

Conditions: Appendicitis

Summary: the investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (ct)-proven complicated appendicitis with phlegmon or abscess.

complicated appendicitis with abscess or phlegmon represents a challenging problem to emergency general surgeons, and the preferred treatment remains controversial. a variety of therapies have been recommended including early operative intervention, delayed operative intervention, and non-operative management. recently, a prospective randomized controlled trial from a single center was conducted in finland comparing operative and non-operative management of appendiceal abscess. patients managed in the operative arm were found to have a shorter length of stay, fewer re-admissions, and fewer additional interventions than those managed in the non-operative group, but there is no high-quality randomized control trial conducted in the united states to support this. the investigators, therefore plan to carry out a multi-center, patient choice study comparing operative and non-operative management of complicated appendicitis with abscess or phlegmon in the united states.

Eligibility criteria:
inclusion criteria: 1. complicated appendicitis with presumed perforation on (computer tomography) ct scan and phlegmon or abscess greater than 2 centimeter (cm). exclusion criteria: 1. antibiotic therapy greater than 24 hours prior to considering for enrollment. 2. attempted drainage before randomization 3. pregnancy 4. antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy. 5. previous major intra-abdominal surgery by laparotomy 6. hospitalization within 2 weeks of randomization 7. presence of septic shock on admission. 8. mechanical ventilation 9. acute renal failure requiring dialysis
twelve month study comparing paliperidone palmitate and select oral antipsychotics in adults with schizophrenia who have been recently discharged from an inpatient psychiatric hospital

Conditions: Schizophrenia

Summary: the study will assess the use of paliperidone palmitate compared with oral antipsychotic treatment in delaying time to a protocol-defined treatment failure over 12 months, in patients diagnosed with schizophrenia who were recently released from an inpatient psychiatric hospital.

the primary objective of this study will be to compare paliperidone palmitate treatment with the randomly assigned oral antipsychotic treatment in delaying time to treatment failure over 12 months in subjects diagnosed with schizophrenia who were recently discharged from an inpatient psychiatric hospital. patients will receive either paliperidone palmitate 78, 117, 156, or 234 mg monthly by injection for twelve months or oral aripiprazole, haloperidol, olanzapine, paliperidone, perphenazine, quetiapine, and risperidone at doses selected by the study doctor.

Eligibility criteria:
inclusion criteria: * must be able to understand and sign the informed consent form approved by the institutional review board (irb) * must be an outpatient who, following an acute exacerbation of schizophrenia, has been discharged from an inpatient psychiatric hospital within 60 days of screening * have a current diagnosis of schizophrenia * have available a designated individual who is likely to have knowledge of the subject's health status and who agrees to let the study site personnel know of changes in the patient's circumstances * women must be postmenopausal (for at least 2 years), surgically sterile (hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy), abstinent, or if sexually active, be practicing a highly effective method of birth control exclusion criteria: * allergies, hypersensitivity (anaphylaxis-type reaction), or intolerance to risperidone or paliperidone * actively abusing intravenous drugs * have a positive urine drug screen test for barbiturates, cocaine, amphetamines, or opiates at screening * have an unstable medical illness * women who are pregnant or breast-feeding, or planning to become pregnant * have received injectable antipsychotic treatment within 2 injection cycles prior to screening * received treatment with clozapine within 3 months of screening * attempted suicide within 6 months before screening or are at imminent risk of suicide or violent behavior, as clinically assessed by the investigator at time of screening * homeless at time of stuyd consent

Keywords: schizophrenia risperidone risperdal paliperidone palmitate aripiprazole haloperidol olanzapine paliperidone perphenazine quetiapine
french validation of the adt-physio scale

Conditions: Cystic Fibrosis

Summary: the goal of this observational study is to translate and validate the adt-physio scale in french, and to validate on a large number of patients the french translation of the adt-physio scale as a tool for evaluating adherence and perception of the intervention of a physiotherapist in patients with cystic fibrosis. participants will have to answer the french trans-adt scale, the brief cope and gses questionnaire.

cystic fibrosis is one of the most frequently encountered rare genetic diseases. in 2022, this pathology affected 7,743 people in the french population, i.e. 3% more than in 2021. previously, this fatal disease only granted a few months of life to child carriers. today, the median age at death is over 40 years old. the adult population suffering from cystic fibrosis has thus become more numerous than the pediatric population. among existing treatments, respiratory and musculoskeletal massage physiotherapy occupies a central place in patients' lives. however, the level of adherence to massage physiotherapy is low among young adults (16 to 21 years old) compared to other types of treatments. faced with epidemiological changes and the daily burden that this chronic pathology represents for those affected, therapeutic adherence should be a major concern for physiotherapists. indeed, a low level of adherence would increase treatment failures, the risk of premature death, episodes of exacerbations and hospitalizations and would thus reduce quality of life. it is therefore crucial to have means of assessing this parameter in patients with cystic fibrosis. the adt physio self-assessment questionnaire, validated in spanish since 2020, has shown clinical validity and reliability for spanish-speaking patients. thus, a version of this scale translated and validated in french would offer physiotherapists a relevant tool allowing them to evaluate therapeutic adherence and the perception of their interventions with french-speaking patients suffering from cystic fibrosis.

Eligibility criteria:
inclusion criteria: the subjects recruited are patients with cystic fibrosis, over 18 years old, without a lung transplant and able to answer the questionnaires.

Keywords: translation cystic fibrosis
phase iii clinical study in patients with mild to severe scalp psoriasis

Conditions: Scalp Psoriasis

Summary: a randomized, double-blind, vehicle-controlled, parallel-design, multiple-site, phase iii clinical study to evaluate the efficacy and safety of dsxs topical product in patients with mild to severe scalp psoriasis

to evaluate the therapeutic efficacy and safety of dsxs topical product (taro pharmaceuticals, u.s.a., inc.) compared to a vehicle topical product (taro pharmaceuticals, u.s.a., inc.) in patients with mild to severe scalp psoriasis.

Eligibility criteria:
inclusion criteria: * male or non-pregnant, non-lactating females 18 years of age and older. exclusion criteria: * females who are pregnant, lactating or likely to become pregnant during the study.
fitjoints: getting fit for hip and knee replacement

Conditions: Hip Osteoarthritis; Knee Osteoarthritis

Summary: total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. the number of people waiting for elective surgeries has spiked in the covid-19 pandemic. prior to covid-19, up to 40% of patients receiving joint replacement were frail and this number is rapidly increasing with longer wait-times and deconditioning associated with covid-19 physical distancing. there is an urgent need to be responsive to the evolving challenges of healthcare. the proposed study is the first multi-site randomized controlled trial (rct) to examine whether a multimodal frailty reduction intervention before surgery will improve postsurgical outcomes for this population. the covid-19 adapted hybrid model includes a multimodal frailty intervention that may be implemented either in person or virtually and is aligned with international consensus guidelines on frailty reduction. to utilize the fitjoints multimodal frailty intervention to build resilience of patients undergoing joint replacement surgery to improve post-operative outcomes. the investigators hypothesize the fitjoints multimodal frailty intervention, with exercise, nutrition and medication optimization, will reduce frailty and pain while improving function and quality of life. building upon the success of the fitjoints feasibility study (n=69) in hamilton, ontario, in the proposed multi-site rct (n=192), older adults (≥60 years) undergoing hip or knee joint replacement surgery who are frail will be randomized to either the 3 to 6-months of multimodal intervention or usual care until the date of their surgery at multiple sites (hamilton health sciences \& st joseph's healthcare hamilton, on; london health science centre, london, on; foothills hospital, calgary, ab),the fitjoints evidence-based, multimodal intervention includes a hybrid model that can be implemented either in person or virtually: 1. physiotherapist supported multi-component exercise program 2. nutrition and protein optimization including dietary counseling 3. medication review with prescribing recommendations


Eligibility criteria:
inclusion criteria: * pre-frail (score of 1 or 2) or frail (score of 3-5) * ≥ 60 years old * receiving elective unilateral total hip or knee replacement * waiting time for surgery is estimated to be between 4 to 15 months exclusion criteria: * renal disorder * a neuromuscular disorder * active cancer * inflammatory arthritis * unable to speak or understand english and has no caregiver for translation * participating in another trial that involves protein supplementation * participating in an exercise program

Keywords: frail elderly arthroplasty pre-rehabilitation
investigation of the safety and efficacy of iguratimod in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: to investigate the safety and efficacy of the administration of iguratimod (crm01t) for 52 weeks in patients with rheumatoid arthritis in clinical practice


Eligibility criteria:
inclusion criteria * participants with rheumatoid arthritis * participants who take iguratimod exclusion criteria * participants registered for this survey previously * pregnant women or women suspected of being pregnant * participants with a serious liver disorder * participants with peptic ulcer * participants with known hypersensitivity to iguratimod or any of its excipients

Keywords: arthritis, rheumatoid, iguratimod
a real-world comparison of fnb and fna in ihc-required lesions.

Conditions: Neuroendocrine Tumors; Autoimmune Pancreatitis; Gastrointestinal Stromal Tumors

Summary: endoscopic ultrasound (eus)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis. the investigators conducted a large, multicenter study to compare the accuracy of diagnosis via specimens collected with fine-needle biopsy (fnb) versus fine-needle aspiration (fna) for patients with lesions requiring immunohistochemistry (ihc) pathological diagnosis.

current guidelines recommend fna and fnb needles equally for pancreatic and other deep-seated lesions. however, some studies indicate that the sample adequacy for histologic evaluation is higher when using fnb compared with fna needles. the diagnosis of neuroendocrine tumor (net), autoimmune pancreatitis (aip), and other gastrointestinal stromal tumors require high-quality tissue sampling for ihc diagnosis. whether fnb is superior to fna in these ihc-required lesions remains unclear. the investigators performed this at 2 tertiary care centers in china. the study prospectively collected patients undergoing eus for a solid mass (\>1 cm) in the pancreas, abdomen, mediastinum, or pelvic cavity from december 2014 diagnosed with aip, net, mesenchymal tumors, and lymphoma. patients accepted fnb or fna according to doctors' and patients' willingness in a real-world setting. all procedures were performed by experienced endosonographers; cytologists and pathologists were blinded to the sample collection method. patients were followed for at least 48 weeks, and final diagnoses were obtained after surgery, imaging analysis, or resolution of the lesion. the primary aim was to compare diagnostic yields of eus-fna with eus-fnb for all solid masses, then separately as aip, net, mesenchymal tumors, and lymphoma. the secondary endpoint was the quality of the histologic specimen.

Eligibility criteria:
inclusion criteria: * age \>18 years; * presence of a solid mass lesion was confirmed by at least 1 imaging modality and it was located within pancreas, abdomen, mediastinum, or pelvic cavity; * mass size \>1 cm; * final diagnoses were obtained after surgery, imaging analysis, or resolution of the lesion, including aip, net, mesenchymal tumors, and lymphoma. exclusion criteria: * coagulopathy (international normalized ratio, 1.5); * thrombocytopenia (platelet count \<50,000/mm3); * acute pancreatitis within the previous 2 weeks; * inability to safely perform eus-ta (eg, cardiorespiratory dysfunction, mental diseases, or drug addiction); * refusal or inability to provide an informed consent.

Keywords: endoscopic ultrasound pathological diagnosis fine needle aspiration fine needle biopsy