Kornimate/medical-research-clean huggingface dataset:
the function of nutrition rich vegan drink on inflammatory bowel disease

Conditions: Recovery

Summary: the aim of this project, would be to develop a new formula, with high nutrition content on a vegan basis. the investigators expect to produce this novel vegan-based juice product, which does not exist on the marked today. the juice would consist of different selected varieties of vegetables and fruits. beside the vegetables, the juice will also contain plant oils to increase the calorie level, as well as a protein sources containing amino acids with high anabolic effects. the products will be tested in an intervention study on patients with inflammatory bowel disease.


Eligibility criteria:
inclusion criteria: * between 18 and 85 years old * diagnosed with or show signs of uc or crohns disease * mild symptoms i.e intestinal symptoms * has had the same medicin the previous week before starting in the study exclusion criteria: * food or vegetable allergi * cognitive diseases e.g alzheimers or dementia * has diabetes requiring insulin or glp-1 analog treatment (nb: no does include t2d patients, taking tablets or other diabetes therapy)
molecular analysis of the sloane project

Conditions: DCIS; LCIS; Atypical Ductal Hyperplasia; Atypical Lobular Hyperplasia

Summary: the sloane project is a uk wide prospective audit of screen detected non-invasive and atypical breast hyperplasias named after john sloane an eminent pathologist interested in the field. non invasive breast neoplasia accounts for 25% of all 'breast cancers' detected through breast screening and includes ductal carcinoma in situ (dcis) and lobular carcinoma in situ (lcis). atypical hyperplasias are high risk but benign lesions found in 10% of benign biopsies performed through the nhs breast screening programme. the importance of these lesions rests on the increased risk of subsequently developing invasive breast cancer, with dcis at highest risk (20 times greater than the general population) followed by lcis (10 times greater) and atypical breast hyperplasia (4 times greater). the sloane project data are held by public health england (phe) and provide full and detailed information about the patients' journey from diagnosis to treatment and outcome. the project aims to increase the understanding of how best to manage these early lesions which can lead to breast cancer. all nhs breast screening units in the uk are invited to submit data for the sloane project. historically an exceptional \~90% of centres in england, scotland, wales and northern ireland have participated on a voluntary basis. the objective of this research protocol is the collection of anonymised formalin fixed paraffin embedded (ffpe) tissue blocks from women whose data is held within the sloane project database in order to allow detailed analysis of the biological, molecular and genomic changes in these cases of in situ carcinoma and atypical hyperplasia and how these relate to the corresponding annotated clinical, pathological and radiological data already collected by and held in phe. we seek to identify particular signature(s) that define which patients are likely to develop invasive disease, distinguishing the worrisome from indolent, non-worrisome lesions.


Eligibility criteria:
inclusion criteria: * dcis (ductal carcinoma in situ) * lcis (lobular carcinoma in situ) * atypical hyperplasias
a study evaluating potential disease-mediated drug-drug interaction in adult participants with active eosinophilic esophagitis receiving cendakimab

Conditions: Eosinophilic Esophagitis

Summary: the purpose of this study to evaluate the potential for disease-mediated drug-drug interactions between cendakimab and selected substrates of metabolic enzymes in eosinophilic esophagitis participants.


Eligibility criteria:
inclusion criteria: * active eosinophilic esophagitis (eoe) with histologic evidence as a peak count of ≥ 15 eosinophils per higher-power field at any 2 levels of the esophagus * previously received an adequate trial of proton-pump inhibitor medication that did not provide complete response to eoe * eoe symptoms documented in daily diary during the screening period exclusion criteria: * on a regimen of therapeutic anticoagulation * demonstrates evidence of immunosuppression or is receiving systemic immunosuppressive or immunomodulating drugs * currently receiving a high potency topical corticosteroid for dermatologic use other protocol-defined inclusion/exclusion criteria apply

Keywords: eosinophilic esophagitis cendakimab drug-drug interactions ddi
a new treatment for premature ejaculation?

Conditions: Premature Ejaculation

Summary: the aim of study is to determine if they can produce increases in the ielt using a masturbator in subjects with premature ejaculation, producing improvements in the quality and satisfaction of the sexuality of the patient.

from the assignment of the devices masturbation aid flip hole by the japanese company tenga® it was possible to begin to develop the study. to shape the patients sample was used to the active search of participants who met with the criteria of incorporation established for the participation in the study, from the publication of the study in different social media (facebook, twitter ...) and the review of the database of the instituto sexológico murciano patients' (ism) who had represented previously with problems of premature ejaculation. first interview with the participants was carried out where it informed them about the collaborative character in the study, together with the informed assent. to determine the suitability of the sample one administered ism's autobiographical questionnaire, the clinical multiaxial inventory of millon-iii (mcmi-iii), and the questionnaire of sexual satisfaction griss (golombok rust sexual inventory of satisfaction), beside gathering a medical report of every patient to reject pathologies that they could interfere with the study. once established the number of participants, 15 males of ages included between 18 and 65 years, there was carried out a follow-up individualized for eight weeks from records of the ielt. during the first two weeks of research the subjects had to register the ejaculatory latency times during the manual masturbation and the intercourse being from the third week when they would use the device flip hole in the manual masturbation either alone or in company of the couple but never during the intercourse. the subjects had to use the masturbator aid at least five times per week for six weeks, during a minimum of five minutes without never overcoming half daily hour and during intercourse. the device flip hole is a masturbation aid made from thermoplastic elastomer (a silicone like substance) that the user inserts their penis in to for stimulation. the patients had to come weekly to ism to deliver the weekly records and to be able to take a follow-up of the subjects along the process. once finished eight weeks of the study one turned them to administer the questionnaire griss to evaluate if changes are produced in the sexual satisfaction of the participants.

Eligibility criteria:
inclusion criteria: * patient meets issm definition of pe * patient is 18 - 65 years exclusion criteria: * patient has significant cardiovascular or neurological pathology. * patient has diabetes mellitus * patient is currently misusing alcohol/drugs * patient meets mcmi-iii criteria for personality disorders and clinical syndromes

Keywords: premature ejaculation treatment sexual dysfunction intravaginal ejaculatory latency time masturbation aid ejaculatory disorders
mottling score and central venous oxygen saturation in septic shock patients

Conditions: Central Oxygen Saturation; Microcirculation; Mottling Score; Septic Shock

Summary: mottling score and central venous oxygen saturation are described as a clinical evaluation of tissue perfusion. this study describes mottling incidence and mottling score in septic shock patients according to central venous oxygen saturation.

this study prospectively analyzed the data of patients admitted to our icu between october 2022 to december 2022. all septic patients in whom the scvo2 was measured and mottling scores were evaluated were included. this study enrolled patients aged ≥ 18 years in septic shock. those excluded have peripheral arterial disease, black skin, cutaneous infection of the lower limbs, pregnancy, and relative refusal. the characteristics of patients were recorded at admission (h0), including demographics (age, sex, body mass index (bmi), admission the acute physiology and chronic health evaluation (apache ii) score, glasgow coma scale (gcs) and sequential organ failure assessment (sofa) score. variables such as plasma lactate level, daily urine output, plasma creatinine level, the ratio of arterial oxygen pressure related to inspired oxygen fraction (pao2/fio2), hemoglobin level, heart rate, mean arterial pressure, pulsatile saturation in oxygen (spo2) and body temperature were recorded at h0 and 6 hours after initial resuscitation (h6).

Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years in septic shock. exclusion criteria: * patients having the peripheral arterial disease * black skin, * cutaneous infection of the lower limbs * pregnancy * relative refusal
participation in procurement of tissue, serum, plasma, cell bank, dna and rna samples, and urine for biological studies related to prostate cancer and prostate cancer treatment follow up

Conditions: Prostate Cancer

Summary: this research study is being done to collect regular and routine follow-up information related to the outcome of treatment for prostate cancer. this study is also being done to relate treatment outcome to measurement of substances in the blood such as prostate-specific antigen (psa) and other markers. also environmental and genetic factors that might be responsible for prostate cancer are being investigated.


Eligibility criteria:
inclusion criteria: 1. informed consent explained and signed prior to any study related procedures. 2. age ≥18 years 3. eastern cooperative oncology group (ecog) performance status of 2 or better, or karnofsky performance of 60% or better. 4. histologically confirmed adenocarcinoma of the prostate within 10 years of study entry. 5. willingness to return to mayo clinic rochester for follow-up or participate in mail-in psa processing. 6. must be disease-free from a previous diagnosis of cancer for a period of time = 5 years excluding cutaneous malignancies of squamous cell or basal cell carcinoma. exclusion criteria: 1. life expectancy \< 5 years. 2. inability to return to mayo rochester for follow-up appointments, sera, and urine collection per protocol. 3. previous or a concurrent diagnosis of cancers other than basal cell or invasive squamous cell carcinoma of skin within the past 5 years.

Keywords: prostate cancer
safety and efficacy study of lx103 treatment of x-linked retinoschisis (xlrs)

Conditions: X-linked Retinoschisis

Summary: the goal of this study is to evaluate the safety and efficacy of lx103 treatment of x-linked retinoschisis. this study will enroll subjects aged ≥ 6 years old to receive a single unilateral intravitreal (ivt) injection of lx103 to evaluate its safety and efficacy.


Eligibility criteria:
inclusion criteria: 1. willing to sign the informed consent, and willing to attend follow-up visits. 2. male individual at least 6 years of age with a diagnosis of xlrs and documented mutations in the rs1 gene. 3. the study eye must have a best-corrected e-etdrs visual acuity letter score of less than or equal to 63. exclusion criteria: 1. any eye with disease that would interfere with the fundus examinations. 2. the study eye is receiving topical carbonic anhydrase inhibitor, or has received topical carbonic anhydrase inhibitors in the past three months. 3. the study eye has undergone intraocular surgery within six months prior to enrollment. 4. participant has uncontrolled hypertension or diabetes.
comparison of the effectiveness of the outpatient classical ketogenic diet and modified atkins diet on seizures frequency, nutritional status and some biochemical factors in children and adolescents with intractable epilepsy

Conditions: Epilepsy Intractable

Summary: epilepsy is one of a common neurological disorder. antiepileptic drugs (aeds) are usually the primary treatment of epilepsy. however, almost 30% of patients do not respond to aeds and other treatments including ketogenic diet (kd) are used. the ketogenic diet (kd) is a low-carbohydrate, high fat, adequate-protein diet. in this study, investigators are going to compare two kinds of the ketogenic diet namely classical ketogenic diet and modified atkins diet. fifty children and adolescents with intractable epilepsy will be included, 25 patients in each group, and will receive the diet for three months on non-randomised basis. in the classical ketogenic diet, the diet with a ratio of 4 to 1 (4:1), each 4 grams of fat to each gram of carbohydrate plus protein, will be introduced. classical ketogenic diet will be established on outpatient setting, without fasting and gradually. the modified atkins diet will be applied by the ratio of 1:1 or 2:1, each 1 or 2 grams of fat to each gram of carbohydrate plus protein.


Eligibility criteria:
inclusion criteria: * children and adolescents age 1 to 18 years have not responded well to at least two primary and one secondary antiepileptic drugs have not received ketogenic diet therapy previously absence of renal diseases history absence of cardiovascular diseases history absence of thyroid function disorders history absence of cholesterol level more than 300 mg/dl and triglyceride level more than 200 mg/dl absence of inherited metabolic disorders that are contraindicated for ketogenic diet therapy including fatty acid oxidation disorders exclusion criteria: * onset of complications that threat the life of the patient inability to continue the diet unwillingness to adhere the diet
development and validation of an automated three-dimensional cephalometry method

Conditions: Orthognathic Surgery; Dentofacial Deformities

Summary: this study is aimed to develop and assess the validity of an algorithm for automated three-dimensional cephalometry.

cephalometric analysis is a standardized diagnostic method used daily by orthodontists and maxillofacial surgeons. it is based on linear and angular measurements performed on radiographic images. this examination is traditionally done manually on two-dimensional radiographs, which does not allow to analyze finely the bilateral structures which are found superimposed. cephalometric analysis of three-dimensional imaging (cone beam computed tomography (cbct) or computed tomography scan (ct-scan)) may provide additional diagnostic information, particularly for patients with maxillofacial abnormalities or marked asymmetries. one of the obstacle to the clinical use of three-dimensional cephalometric analysis is the time and expertise needed to manually place the landmarks. automatic methods described in literature are preliminary and lack validation in a clinical context. our retrospective observational study is aimed to develop and validate a new automated three-dimensional cephalometry method. this method will be based on a deep learning algorithm trained from a database of pre-surgery ct-scans of patients with have undergone an orthognathic surgery. these ct-scans will be manually annotated to provide a reference standard for the training of the algorithm and its evaluation. the validation of our results will focus on demonstrating the diagnostic effectiveness and robustness of three-dimensional cephalometric measurements obtained in this clinical context.

Eligibility criteria:
inclusion criteria: 1. patients followed in the maxillofacial surgery department of pitie-salpetriere hospital (ap-hp, paris, france) since 2014; 2. who underwent orthognathic surgery; 3. who had, for surgery planning, a three-dimensional radiographic examination (ct-scan) which has been segmented for the manufacture of a custom-made device; 4. who did not object to the research.

Keywords: imaging, three-dimensional cephalometry anatomic landmarks radiographic image interpretation deep learning orthodontics
relationship between hydrocephalus and endolymphatic hydrops

Conditions: Hydrocephalus

Summary: the goal of this observational study is to assess the prevalence of endolymphatic hydrops in patients with hydrocephalus and assess the auditory functions in patients with hydrocephalus including male and female with 20-60 year age groups. it aims to assess the prevalence of endolymphatic hydrops in patients with hydrocephalus and to assess the auditory functions in patients with hydrocephalus


Eligibility criteria:
inclusion criteria: patients will be diagnosed with hydrocephalus through the neurosurgery department of the same hospital, exclusion criteria: * history of ear diseases * history of dm or hypertension * history of ototoxic drug intake. * congenital anomalies of the auricle or external auditory meatus. * history of hereditary hearing loss in the family * history of noise exposure * other neurological problems apart from hydrocephalus exclusion criteria: -

Keywords: hydrocephalus, endolymphatic hydrops
the leipzig tavi registry

Conditions: Aortic Valve Stenosis

Summary: a single-center registry including all patients treated with tavi at the heart center, leipzig, germany

a single-center registry including all patients treated with transcatheter aortic valve implantation (tavi) at the heart center, leipzig, germany. patients undergo a routine clinical and echocardiographic follow-up schedule, including a long-term follow-up plan up to 10 years to assess valve durability.

Eligibility criteria:
inclusion criteria: * all patients treated with tavi exclusion criteria: * none
water oxygenation and brain activity

Conditions: Muscle Damage

Summary: the primary purpose of this interventional, placebo controlled, crossover, double blind, basic science exploratory study is to investigate whether there is a difference in brain electrophysiological oscillatory activity in healthy adults before and after oral consumption of water containing very small bubbles of oxygen (electrokinetically modified water).


Eligibility criteria:
inclusion criteria: * men or women of any ethnic background; * living in new york tri-state area; * fluent in english; * normal or corrected to normal vision and hearing; * willing to complete all study procedures; and * capable of giving written informed consent. exclusion criteria: * a history of gross brain abnormalities such as stroke, severe ventriculomegaly or severe periventricular white matter abnormalities; * a history of serious psychiatric or neurological disorders, including psychosis or major depression, alcohol or drug abuse, brain injury, seizure disorder, brain tumor, etc.; * taking psychoactive medications, including antipsychotics, anxiolytics and antidepressants, or cognitive enhancers such as cholinesterase inhibitors; * presence of contraindications for meg or mri recording, including any of the following: cardiac pacemaker, intracranial clips, metal implants, or external clips within 10 mm of the head, metal in eyes, claustrophobia, obesity and/or any other reason leading to difficulty staying in the meg or mri for up to one hour.

Keywords: strenuous exercise muscle soreness
ovarian tissue transplantation

Conditions: Infertile Females or Females With Ovarian Insufficiency

Summary: chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. ovarian tissue cryopreservation is an experimental strategy offered at the university of pennsylvania to preserve future fertility (protocol 806062). the primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.


Eligibility criteria:
inclusion criteria: * female patient between the ages of 18 and 45 years * previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation * ovarian insufficiency defined as an elevated fsh over 10 * inability to conceive after 6 months of unprotected intercourse with male * reasonably good health * candidate for pregnancy * written clearance for the procedure from the patients oncologist exclusion criteria: * patients considered to be high risk for surgical complications will be excluded from the research protocol * women who are known to be positive for the brca mutation * women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection * women with psychological, psychiatric, or other conditions which prevent giving fully informed consent * current pregnancy
dose escalation of rmc-5552 monotherapy in relapsed/refractory solid tumors

Conditions: Solid Tumors

Summary: the purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (pk), and pharmacodynamic (pd) profiles of escalating doses of rmc-5552 monotherapy in adult participants with relapsed/refractory solid tumors and to identify the recommended phase 2 dose (rp2d).

this is an open-label, multicenter, phase 1/1b study of rmc-5552 monotherapy in participants with advanced relapsed or refractory solid tumors. the study will include 2 components: 1) a dose-escalation component for participants with relapsed or refractory solid tumors and 2) a dose-expansion component for participants with relapsed or refractory solid tumors harboring certain specific mutations/rearrangements that result in hyperactivation of the mtor pathway. participants will be treated until disease progression per recist v1.1, unacceptable toxicity, or other criteria for withdrawal are met, whichever occurs first.

Eligibility criteria:
inclusion criteria: * participants (male or female) ≥18 years of age * participants who have advanced solid tumors that have failed, are intolerant to, or are considered ineligible for standard of care anticancer treatments including approved drugs for oncogenic drivers in their tumor type * eastern cooperative oncology group (ecog) performance status of 0 to 1 * participants in the dose-expansion component must have molecular aberrations in the mtor pathway * adequate hematologic, hepatic and renal function exclusion criteria: * known or suspected leptomeningeal or brain metastases or spinal cord compression * primary central nervous system (cns) tumors * clinically significant cardiac disease * active, clinically significant interstitial lung disease or pneumonitis * subjects with abnormal fasting glucose, type 1 diabetes, or uncontrolled type 2 diabetes are excluded. * subjects with stomatitis or mucositis of any grade

Keywords: pik3ca pten tsc1/2 stk11 mtor myc mapk advanced solid tumor advanced solid malignancies melanoma skin cancer ovarian cancer endometrium/uterus cancer bladder cancer cervical cancer carcinoma, non-small-cell lung neoplasms, squamous cell carcinoma, squamous cell esophageal neoplasms carcinoma, bronchogenic bronchial neoplasms lung neoplasms respiratory tract neoplasms thoracic neoplasms neoplasms by site neoplasms lung diseases respiratory tract diseases neoplasms, glandular and epithelial gastrointestinal neoplasms digestive system neoplasms head and neck neoplasms digestive system diseases esophageal diseases gastrointestinal diseases 4ebp1