Kornimate/medical-research-clean huggingface dataset:
effects of normobaric hypoxia during exercise in patients with pulmonary hypertension with/without sildenafil

Conditions: Hypertension, Pulmonary

Summary: to study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without sildenafil


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature (appendix informed consent form) * ph class i (pah) or iv (cteph) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmhg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmhg during baseline measures at the diagnostic right-heart catheterization exclusion criteria: * resting partial pressure of oxygen \<8 kilopascal at zürich altitude on ambient air * exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study * inability to follow the procedures of the study * patients who take nitrates * other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)

Keywords: hypoxia exercise sildenafil
finances first: a health intervention in low income single mother households

Conditions: Financial Stress

Summary: the purpose of this prospective, randomized, controlled three-year study is to compare the effect of a year-long financial education program versus usual care on health outcomes in single mother low income households.


Eligibility criteria:
inclusion criteria: * unmarried * currently employed * annual salary must be less than 200% of the federal poverty guideline * supporting at least one child at home * able to read and speak either english or spanish exclusion criteria: * currently abusing alcohol or recreational drugs * currently living in a domestic violence situation * pregnant or planning to become pregnant in the next year
complications after endosonography and guided bronchoscopy

Conditions: Complication of Bronchoscopy

Summary: the present study aims to investigate prospectively and systematically the direct and indirect complications occurring within 30 days after guided-bronchoscopy and/or endosonography. the results of the study should reliably help clarify further incidence, pattern, risk factors, and outcomes for both immediate and late complications associated with these key diagnostic procedures.


Eligibility criteria:
inclusion criteria: * age \>18 years, * indication to undergo bronchoscopy, endosonography, or both. * signed informed consent exclusion criteria: * absolute contraindications to the bronchoscopic examination based on international guidelines \[31\]. * platelet count \<50000

Keywords: endosonography guided bronchoscopy complications hospital admission lung cancer
prospective evaluation of peripartum anticoagulation management for thromboembolism

Conditions: Pregnancy Related; Venous Thromboembolism

Summary: the prep and go study is an international multicentre prospective cohort evaluating anticoagulation management strategies around labor and delivery and the postpartum period.

the goal of this study is to provide quality data using standardized outcome definitions on postpartum bleeding events, venous thromboembolism (vte) risk, delivery experience outcomes and health care utilization for intrapartum and postpartum anticoagulation management among pregnant individuals on low-molecular-weight heparin (lmwh) for prevention of treatment of vte.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * requires anticoagulation during the antepartum period of pregnancy for a vte indication, including at least one of: 1. objectively confirmed vte (dvt, superficial vein thrombosis \[svt\], pe or unusual site thrombosis) diagnosed during the current pregnancy; 2. objectively confirmed vte diagnosed in a prior pregnancy; 3. objectively confirmed vte diagnosed when not pregnant; 4. inherited or acquired thrombophilia requiring anticoagulation. * receiving any dose or type of lmwh during the antepartum period exclusion criteria: * anticoagulation for a non-vte indication, including prosthetic heart valves, atrial fibrillation, prevention of placenta-mediated pregnancy complications, or prevention of recurrent pregnancy loss (participants can be included with a diagnosis of antiphospholipid syndrome (aps) with or without thrombotic events) * unable to provide or declined consent. * home or birthing centre planned delivery.
early mobilization after colorectal surgery

Conditions: Colonic Diseases; Rectal Diseases

Summary: early mobilization (i.e. initiation of out of bed activities from the day of surgery) is considered an important component of postoperative care after colorectal surgery. having a health professional dedicated to facilitate early mobilization has the potential to enhance postoperative recovery by preventing the negative effects of prolonged bed rest (e.g. increased risk for complications, muscle loss, deconditioning and functional decline); however, the need to implement this resource-intensive approach is not evidence based. this study aims to contribute evidence about the role of facilitated early mobilization as a strategy to enhance recovery after colorectal surgery.

the primary research question of this study is: to what extent does postoperative facilitation of early mobilization impact on recovery of functional walking capacity at 4 weeks after surgery in comparison to standard care (preoperative education). the hypothesis is that, by 4 weeks after surgery, facilitated early mobilization will result in a greater proportion of participants returning to preoperative levels of functional walking, as measured by the six-minute walk test (6mwt).

Eligibility criteria:
inclusion criteria: * adult people (\>18 years) * colonic or rectal diseases (i.e. cancer, inflammatory bowel disease, diverticulitis) planned for surgical resection exclusion criteria: * metastatic disease * medical conditions that preclude postoperative mobilization (e.g. neurological or musculoskeletal diseases) * inability to understand english or french * admission to intensive care immediately after the surgery

Keywords: colorectal surgery postoperative recovery early mobilization
characterisation of circadian rhythm in autistic spectrum disorder

Conditions: Autistic Disorder

Summary: autism spectrum disorders (asds) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. results from genetic studies reveal one pathway associated with susceptibility to asds, which includes synaptic cell adhesion molecules. among the factors that could modulate this pathway are the genes controlling circadian rhythms. sleep disorders and low melatonin levels are frequently observed in asds. thus investigator will characterize the circadian rhythms of patients with asd and search for circadian rhythms genes polymorphisms.


Eligibility criteria:
inclusion criteria: * patients with autistic spectrum disorders * at least 6 years old * membership of a social security scheme * informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship exclusion criteria: * recent sleep symptoms * incapacity to keep rested for 24 hours

Keywords: circadian rhythm
replacing canes with an elasticated orthosis in chronic stroke patients: the influence on gait and balance. a series of n-of-1 trials

Conditions: Stroke

Summary: this study aims to investigate the effect of an elasticated orthotic garment "thera togs" on walking ability and balance in currently cane using chronic stroke subjects (minimum 6 months post stroke) using a series of n-of-1 trials.

aim: to investigate the effect of replacing canes with an elasticated orthotic-garment on gait and balance in chronic stroke subjects. design experimental, multiple baseline n-of-1 series with an abc design with randomised period duration. participants four cane using chronic stroke subjects. interventions phase a (9-12 weeks) usual cane-walking to establish baseline values; phase b (9-19 weeks) intervention: orthotic-garment worn throughout the day with maximal cane reduction; phase c (9-10 weeks) individually determined follow-up: either no walking-aid, orthotic-garment or cane. weekly measurement of outcome measures for gait and balance function

Eligibility criteria:
inclusion criteria: * chronic stroke (\> six months since last stroke) * independent cane walkers. subjects usually use canes to walk inside (this could be intermittent changing from cane to holding furniture etc.) and always when outside * a mini mental score of 22 or above. exclusion criteria: * patients at risk of falling identified as a berg balance score ≤42/56

Keywords: stroke hemiplegia
study of efficacy of welt-ip in insomnia (wctp-i-b-02)

Conditions: Insomnia

Summary: the purpose of the study was to determine safety and efficacy of welt-ip in adult insomnia patients. welt-ip is a cognitive behavioral therapy for insomnia (cbt-i) based digital therapeutics.

this was a randomized, double-blinded, sham-controlled trial. overall, 68 subjects were randomized into the following groups: * welt-ip group: welt-ip (insomnia digital therapeutics) use * control group: sham app use subjects in both groups continued to receive their clinician-directed standard-of-care treatment for insomnia, if applicable, including pharmacotherapy. after screening of sleep diary, subjects were randomized and in welt-ip group used welt-ip and subjects in control group used a sham for a period of 6 weeks.

Eligibility criteria:
inclusion criteria: * dsm-5 insomnia patient * se (sleep efficiency) \<80% * completing screening sleep diary of 7 consecutive days * isi of 8 or above * capable of using mobile device and application exclusion criteria: * currently on non-pharmacological treatment for insomnia (ex. cbt-i, light therapy, oriental therapy for insomnia) * sleep disorders diagnosis other than insomnia (ex. obstructive sleep apnea, sleep behavior problem, restless leg syndrome) * progressive and active medical conditions * received continuous psychotherapy such as cbt, motivational enhancement therapy, psychotherapy, and psychoanalysis in the past 3 months * major psychiatric illness as assessed through mini * suicide risk as assessed through c-ssrs * having occupational risk due to sleep restriction * shift workers

Keywords: digital therapeutics
testosterone replacement in renal failure

Conditions: Hypogonadism

Summary: the purpose of this trial is to evaluate the effect of testosterone replacement in men with renal failure (on dialysis) who also have low testosterone. specifically, the investigators will assess the change in requirement of erythropoietin stimulating agents.

testosterone replacement can increase hemoglobin count. this can therefore decrease the requirement of erythropoietin stimulating agents.

Eligibility criteria:
inclusion criteria: 1. men between ages of 18-80 years of age. 2. renal failure on hemodialysis 3. free testosterone \<5 ng/dl. 4. willing to be randomized to intramuscular (im) testosterone or placebo 5. currently getting intravenous epoetin alfa exclusion criteria: 1. use of testosterone treatment currently or in the past 6 months, including use of over the counter androgen containing health supplements. 2. congestive heart failure, class iii or iv. 3. baseline hemoglobin of \> 12 g/dl. 4. allergic reactions to testosterone vehicle (i.e. peanut oil) 5. prostate specific antigen\>4 ng/ml. 6. history of prostate cancer. 7. liver enzymes \>twice the upper limit of normal. 8. hiv or hepatitis c. 9. severe untreated obstructive sleep apnea (defined as apnea-hypopnea index\> 30). 10. subjects on warfarin or other blood thinners. 11. active infection (such as foot ulcer) 12. history of adverse events with testosterone use in past.
effects of exercise and glp-1 agonism on muscle microvascular perfusion and insulin action in adults with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with metabolic syndrome. subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. they will be studied at the baseline and then after 24 weeks of intervention.

our hypothesis is that sustained activation of the glp-1 receptor with liraglutide and exercise training each will enhance microvascular insulin responses and angiogenesis in both cardiac and skeletal muscle to increase muscle insulin delivery and action and the combination of both is more effective than either alone in adults with metabolic syndrome.

Eligibility criteria:
inclusion criteria: * male or female ≥21 and ≤60 years old. * body mass index \>25 and ≤35 kg/m2 and is weight stable (\<5 kg weight change in the past 6 months). bmi is limited to ≤35 kg/m2 for easier vascular access and cardiac imaging. * meet 3 of 5 national cholesterol education program adult treatment panel iii metabolic syndrome criteria: * increased waist circumference (≥102 cm in men; ≥88 cm in women) * elevated triglycerides (≥150 mg/dl) * reduced hdl-cholesterol (\<40mg/dl in men, \<50 mg/dl in women) * high blood pressure (≥130 mmhg systolic or ≥85mmhg diastolic) * elevated fasting glucose (≥100 mg/dl) * subject may participate if on the following drugs, provided the drug doses have been stable for at least 3 months. * ace inhibitor * arb * hmg coa reductase inhibitor * beta blocker * calcium channel blockers * alpha-adrenergic antagonist * statin exclusion criteria: * a diagnosis of any type of diabetes or history of diabetes medication use * recently active (\>20 min of moderate/high intensity exercise, 2 times/week) * subjects who are smokers or who have quit smoking \<5 years * subjects with hypertriglyceridemia (\>400 mg/dl) or hypercholesterolemia (\>260 mg/dl) * subjects with bp\>160/90 * subjects with a history of significant metabolic, cardiac, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or malignancy * pregnant (as evidenced by positive pregnancy test) or nursing women * subjects with contraindications to participation in an exercise training program * allergic to perflutren * a prior use of liraglutide
digoxin versus ivabradine in heart failure with reduced ejection fraction

Conditions: Heart Failure

Summary: study hypothesis: comparing the effect of digoxin and ivabradine in chronic heart failure patients with a left ventricular ejection of 35% or lower and sinus rhythm with heart rate 70 beats per minute or higher, and who are taking maximal dose of a beta blocker if tolerated.

selected patients have chronic heart failure with left ventricular systolic dysfunction and sinus rhythm. they take optimal medical therapy.

Eligibility criteria:
1. inclusion criteria: * left ventricular ejection fraction of 35% or lower (ischaemic or non-ischaemic etiology) * sinus rhythm with heart rate of 70 beats per minute or higher * symptomatic heart failure with functional capacity of new york heart association class ii, iii, iv 2. exclusion criteria: * chronic renal failure with glomerular filtration rate \<30 ml/min * atrial fibrillation * pace maker rhythm * advanced stage chronic obstructive lung disease * comorbidity with expected survival below 1 year

Keywords: heart failure digoxin ivabradine
cognitive motion-based videogames exploratory study in acquired brain injury

Conditions: Acquired Brain Injury

Summary: this study aims to assess the feasibility of intendu cognitive motion-based videogames in acquired brain injury (abi) patients in inpatient treatment and in the community and to evaluate the effects of training on patients' cognitive performance

this study includes three experimental arms to research cognitive video games involving motion interaction in abi population. the study consists of 4 primary phases: recruitment, assessment, intervention and post-intervention assessment. two arms involve a randomized controlled study with inpatient participants, where participants are randomly assigned to an intervention or control group. recruitment phase includes cognitive assessments to evaluate eligibility for the study. in the assessment and post assessment phases cognitive performance is established. intervention includes 10 computerized training sessions of 30-45 minutes over 3 weeks period using intendu functional brain trainer (fbt). the control group intervention involves playing commercial ipad games for the same duration. interventions will be performed in addition to standard inpatient treatment. in addition to the randomized control study, a third experimental arm will be performed, were participants living in the community will perform a similar protocol with cognitive motion-based video games. the recruitment, assessment, post assessment and intervention phases will be similar to the above.

Eligibility criteria:
inclusion criteria: 1. diagnosed with acquired brain injury. 2. at least one functional upper limb. 3. ability to understand instructions that will be assessed by the therapist. 4. basic cognitive ability in orientation, visual perception and spatial perception. 5. impairment in executive functions (ef) as assessed by ef assessments. 6. normal vision. exclusion criteria: 1. untreated epilepsy 2. other psychiatric or neurological disease. 3. neglect or hemianopia. 4. for the community arm - doesn't receive any cognitive therapy.

Keywords: cognitive videogames
brain activity changes following neuroproprioceptive physiotherapy in multiple sclerosis

Conditions: Neuronal Plasticity; Multiple Sclerosis; Rehabilitation

Summary: imaging methods bring new possibilities for describing the brain plasticity processes that underly the improvement of clinical function after physiotherapy in people with multiple sclerosis (pwms). the study determined whether facilitation physiotherapy could enhance brain plasticity, compared two facilitation methods, and looked for any relation to clinical improvement in pwms.

the study was designed as parallel group randomized comparison of two kinds of physiotherapeutic interventions referred to healthy controls. ms patients were examined by fmri (primary outcomes) and clinical tests (secondary outcomes) at the beginning of study. then, they were randomly divided into two groups (by drawing lots in a 1:1 ratio). the first group underwent vojta reflex locomotion (vrl), and the second motor program activating physiotherapy (mpat). the length and intensity of treatment was the same in both groups (two months, one hour twice a week). after the treatment, a clinical and fmri examination was performed. healthy volunteers underwent an fmri examination that was considered to be a control.

Eligibility criteria:
inclusion criteria: * definite ms * stable clinical status in the preceding 3 months * imuno-modulatory treatment for at least two years (including glatiramer acetate, interferon beta-1a, 1b, mitoxantrone, fingolimod, natulizumab) * expanded disability status scale (edss)≤6 * predominant motor impartment * six months or more without any physiotherapy * ability to undergo ambulatory physiotherapy exlusion criteria: -other neurological disease or conditions disabling movement
effect of commiphora myrrh solution as a root canal irrigant on post operative pain and bacterial load reduction in necrotic tooth

Conditions: Necrotic Pulp

Summary: clinically compare the post-operative pain , incidences post-operative swelling , post-operative number of analgesic tablets taken by patient and amount of bacterial load reduction after using 50% commiphora myrrh chemomechanical preparation , versus 2.5% naocl,in asymptomatic necrotic mandibular premolar treated in single visit.

the patients will be randomly divided into 2 groups. intervention group (50% commiphora myrrh solution root canal irrigant) and control group (2.5% sodium hypochlorite root canal irrigant) post-operative pain will be measured at 6,12,24,48 hours post-operatively the pain will be recorded using numerical rating scale post-operative swelling will be measured at 6,12,24,48 hours post-operatively the swelling will be receded using visual swelling rating scale number of analgesic tablets taken by the patient post-operatively. up to 48 hours amount of bacteria load reduction the intracanal bacterial load reduction will be determined using agar culture technique by counting the colony forming units per milliliter (cfi /ml) before and after root canal preparation.

Eligibility criteria:
inclusion criteria: 1. systemically healthy patient (asa i, ii). 2. age between 20 and 40 years. 3. male or female. 4. patient who is able to sign and comprehend the pain scale (committed patient). 5. mandibular single rooted premolars having the following criteria: * with single root canal. * diagnosed clinically with pulp necrosis. * absence of spontaneous pulpal pain. * positive pain on percussion denoting apical periodontitis. * slight widening of periodontal space or peri-apical radiolucency smaller than 3 mm (0-2mm) exclusion criteria: 1. medically compromised patients (asa iii or iv). 2. teeth with: 3. patients who could not interpret the nrs. * immature roots. * vital pulp tissues. * association with swelling. * acute peri-apical abscess or acute exacerbation of a chronic abscess. * mobility grade ii or iii. * previously accessed or endodontically treated. * deep periodontal pockets more than 4 mm. * vertical root fractures, coronal perforation, calcification, and external or internal root resorptions. 4. patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women will be also excluded. 5. history of intolerance to nsaids.

Keywords: asymptomatic necrotic mandibular premolar
obesity and liver function in oesophageal cancer

Conditions: Obesity; Liver Function

Summary: there is an established link between sarcopenia and outcomes in oesophageal cancer. there is scant reports in the literature regarding the influences of different obesity in different compartments.

oesophageal cancer rates are increasing as a result of obesity in western society. thr investigators are evaluating the influence of viscerala dn subcutaneous obesity on overall outcomes of the participants. in addition the investigators are evaluating if there is a correlation with liver function tests and liver histopathology such as steatosis on survival in participants and post operative sequele.

Eligibility criteria:
inclusion criteria: * those undergoing oesophagectomy exclusion criteria: * patients who only had chemotherapy/chemoradiotherapy without surgery