Kornimate/medical-research-clean huggingface dataset:
anemia and duration of mechanical ventilation

Conditions: Anemia; Mechanical Ventilation; Critically Ill; Intensive Care Unit; Morality; Organ Dysfunction Syndrome

Summary: in mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. we aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support \>96 hr.

anemia is one of the most common conditions encountered critically ill patients. various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. anemia can affect cardiopulmonary function as depletion in oxygen content in body. in mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. some research suggested that hemoglobin level \ 96 hr. however, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. to the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. we hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. we, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support \>96 hours.

Eligibility criteria:
inclusion criteria: * patients whose age of equal or more than 18 years old * patients admitted to the surgical intensive care unit during the study period * patients required ventilatory support with invasive mechanical ventilation for more than 96 hours exclusion criteria: * patients whose data regarding time of beginning or ending of ventilatory support missed * patients who are previously included in this study and are re-admitted

Keywords: duration of mechanical ventilation duration of anemia intensive care unit mortality organ dysfunction
web-based management of female stress urinary incontinence

Conditions: Female Stress Urinary Incontinence

Summary: the purpose of this study is to determine whether treatment of female stress urinary incontinence using a web-based programme is effective.

female urinary incontinence is very common and affects up to one fourth of grownup women. it may reduce quality of life for those affected and costs for society are high. the most common type of urinary incontinence is stress urinary incontinence (sui), i.e leakage when coughing, sneezing or jumping. there is no association between sui and serious medical conditions. thus investigation can be kept to a minimum, including structured history taking and a bladder diary for correct diagnosis. treatment with lifestyle intervention and pelvic floor muscle training (pfmt) give improvement or cure in 60-70% of women. a small study indicates that treatment with cognitive behavioural therapy (cbt) may improve incontinence-related quality of life and symptoms of urinary incontinence. web-based management of sui has as far as we know never been evaluated in a randomized controlled study. the aim of this study is to determine if web-based management of female sui, with a treatment using pfmt and elements of cbt is effective compared to treatment supported by a pamphlet. the duration of the treatment programme is three months, follow-up at four months, 1 year and two years.

Eligibility criteria:
inclusion criteria: * stress urinary incontinence * leakage once a week or more often * ability to read and write swedish * asset to computer with internet connection exclusion criteria: * pregnancy * former incontinence surgery * known malignancy in lower abdomen * difficulties with passing urine * visual blood in urine * intermenstrual bleeding * severe psychiatric diagnosis * neurological disease with affection on sensibility in legs or lower abdomen

Keywords: female stress urinary incontinence treatment pelvic floor muscle training cognitive behavioral therapy internet life style pamphlet ehealth
nivolumab +/- ipilimumab immunomonitoring in metastatic melanoma

Conditions: Metastatic Melanoma

Summary: this is an open bi-centric prospective non-randomized study in patients with metastatic melanoma treated with a first line treatment of nivolumab +/- ipilimumab. the aim of the study is to characterize the immune cells modulations under anti-pd-1 +/- anti-ctla4 and identify the differences between responder and non-responder patients.


Eligibility criteria:
inclusion criteria: * men and women aged ≥ 18 years of age. * patient with metastatic or unresectable melanoma * nivolumab or nivolumab + ipilimumab treatment indication * skin biopsies available * patient affiliated to or a beneficiary of a social security category. * signed written informed consent. * patient who agrees to the storage of his biological samples exclusion criteria: * treated haematological malignancies subjects with a condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications * patients with autoimmune disease. * ocular melanoma

Keywords: melanoma nivolumab ipilimumab immune modulation
cabg based on ct-ffr versus conventional coronary angiography

Conditions: Coronary Artery Disease

Summary: the aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (cabg) based on conventional coronary angiography(cag) versus cardiac computed tomography(ct)-derived fractional flow reserve(ffr), and (2) to demonstrate difference in clinical outcomes between the 2 groups.

the cabg-corea trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. patients were randomized by use of a randomization table. coronary arteries are revascularized based on conventional coronary angiography (quantitative coronary angiography) or cardiac computed tomography-derived fractional flow reserve according to the randomization result. the primary end point is to evaluate early and 1-year postoperative graft patency. the secondary end points are overall survival, freedom from cardiac death and freedom from macce(major adverse cardiac or cerebrovascular events).

Eligibility criteria:
inclusion criteria: * age equal or more than 40 * age equal or less than 80 * patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease * patients who agree to the enrollment exclusion criteria: * patients with heart failure (left ventricular ejection fraction \< 25%) * patients who have intractable ventricular arrhythmia * patients who has been treated for cancer * patients who has infectious disease * patients who are planned to undergo combined cardiac surgery * patients who has medical co-morbidity with expected survival less than 1 year * patients with a history of previous cardiac surgery * patients with chronic renal failure requiring dialysis * patients who undergo emergency operation
dietary intake, death and hospitalization in adult with end-stage kidney disease treated with hemodialysis (diet-hd) study

Conditions: Diet Habit; End Stage Renal Disease

Summary: the dietary intake, death and hospitalisation in adults with end-stage kidney disease treated with haemodialysis (diet-hd) study is a multinational prospective cohort study designed to evaluate the association between nutrition and dietary patterns and health outcomes in prevalent adult haemodialysis patients in europe and south america.


Eligibility criteria:
inclusion criteria: * end-stage kidney disease * long-term haemodialysis for at least the previous 90 days * 18 years or older * treating team agrees to the patient's involvement in the study * participant willing to provide written and informed consent.- exclusion criteria: * significant neurocognitive disability or medical comorbidity that would preclude them from understanding the dietary questionnaire even if assisted * a life expectancy less than 6 months according to their treating physician * planned kidney transplantation within 6 months of baseline

Keywords: nutrition hemodialysis mortality omega 3
real-time margin assessment in head and neck cancer

Conditions: Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma

Summary: to investigate if the combination of fresh frozen sectioning based on cetuximab-800cw can enhance tumor-positive margin detection intra-operatively.


Eligibility criteria:
inclusion criteria: * cytology and/or histology-confirmed diagnosis of oral squamous cell carcinoma and scheduled to undergo surgical removal as decided by the multidisciplinary head and neck tumor board of the umcg; * age ≥ 18 years; * written informed consent. exclusion criteria: * medical or psychiatric conditions that compromise the patient's ability to give informed consent; * concurrent uncontrolled medical conditions; * received an investigational drug within 30 days prior to the dose of cetuximab-800cw; * history of myocardial infarction, cerebrovascular accident, uncontrolled cardiac heart failure, significant liver disease (alt \>3x upper limits of normal or increased total bilirubin) or unstable angina within 6 months prior to enrollment; * inadequately controlled hypertension with or without current antihypertensive medications; * history of allergy or infusion reactions cetuximab or other monoclonal antibody therapies; * pregnant or lactating women. documentation of a negative pregnancy test must be available for women of childbearing potential. moreover, the need to be willing to ensure that she or her partner uses effective contraception during the trial and for 6 months thereafter. woman of childbearing potential are premenopausal women with intact reproductive organs and women less than two years after menopause; * evidence of qt prolongation on pretreatment ecg (greater than 440 ms in males or greater than 450 ms in females) * patients receiving class 1a (quinidine, procainamide) or class iii (dofetilide, amiodarone, sotalol) antiarrhythmic agents. * life expectancy \< 12 weeks;

Keywords: cetuximab-800cw fluorescence guided surgery
study of macroplastique safety and effectiveness in the treatment of female stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: the rose registry will determine the long-term safety and effectiveness of macroplastique in the treatment of female stress urinary incontinence (sui) due to intrinsic sphincter deficiency (isd).

the rose registry is a five-year post-market study of the safety and effectiveness of macroplastique in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency.

Eligibility criteria:
inclusion criteria: * subject has signed written informed consent * subject is a female at least 18 years of age * subject has been diagnosed with sui primarily due to intrinsic sphincter deficiency (isd) * subject understands all study requirements including five year follow-up schedule * subject is psychologically stable and suitable for intervention as determined by the investigator exclusion criteria: * subject has an acute urogenital tract inflammation or infection * subject is pregnant or intends to become pregnant within one year * subject has had a sling placement within 12 weeks * subject has had a bulking agent treatment within 12 weeks * subject has a bladder neck or urethral stricture, gross utero-vaginal prolapse, untreated detrusor instability or hyperreflexia, neuropathic bladder, or overflow incontinence

Keywords: stress urinary incontinence silicone elastomer
the accuracy of amniotic fluid ferning in the second trimester in the diagnosis of preterm prelabor rupture of membranes

Conditions: Preterm Premature Rupture of Membrane; Amniotic Fluid Leakage

Summary: although much investigation has been done on the use of ferning in the second and third trimesters, particularly with the development of rapid protein clinical assays, there appears to be lower ferning rates in clinical practice with traditional techniques compared to previous published research on the subject. much of the older study designs are lacking in detail and lack a large enough sample sizes at each gestational age to appropriately interpret the significance of ferning results by gestational age. additionally, a large premise for the current tests used to diagnose rupture of membranes is based on these older studies. given this, we propose collecting amniotic fluid vaginally to evaluate for the presence of ferning in the second trimester to determine if there is a difference in ferning based on gestational age as well as the time interval after rupture of membranes in which ferning can observed on microscope examination.


Eligibility criteria:
inclusion criteria: * 18 years or older * english speaking * singleton or multi fetal gestation * between 15 and 24 weeks gestation * undergoing elective pregnancy termination exclusion criteria: * known rupture of membranes or anhydramnios
continuous assessment of hemodynamic compensation in pediatric trauma patients

Conditions: Trauma

Summary: this is an observation study using the flashback cri t1 tablet to collect data on compensatory reserve index in pediatric trauma patients. highest trauma activations at the institution will be enrolled in the study and data will be collected for 12-24 hours based on the patient's hemodynamic status. the device collects data via a pulse oximeter probe. no treatment decisions will be made based on the values of the on the cri tablet. data will be retrospectively reviewed to determine if any trends exist that correlate with blood loss, need for operation or blood transfusion.


Eligibility criteria:
inclusion criteria: • children 31 days through 26 years (inclusive) of age who undergo trauma red (highest level) activation or trauma level 1 (mid-level) activation at children's hospital colorado or children's national medical center. exclusion criteria: * pregnant patients * incarcerated patients * patients who object to study participation at any time * limited access to or compromised monitoring sites for non-invasive finger sensors * brain death (gcs 3 with fixed, dilated pupils)

Keywords: pediatric
study to evaluate safety, pharmacokinetics, and antiviral activity of bictegravir (gs-9883) in human immunodeficiency virus (hiv)-1 infected participants

Conditions: HIV-1 Infection

Summary: the primary objective of the study is to investigate the short-term antiviral potency of bictegravir at multiple doses in antiretroviral (art) treatment-naive adult participants and participants who are art-experienced but integrase strand transfer inhibitor (insti) naive.


Eligibility criteria:
key inclusion criteria: * no current or prior anti-hiv treatment, including art medications received for prevention (preexposure prophylaxis \[prep\]), or postexposure prophylaxis (pep) within 12 weeks of screening * plasma hiv-1 ribonucleic acid (rna) ≥ 10,000 copies/ml but ≤ 400,000 copies/ml at screening * cluster of differentiation 4+ (cd4+) cell count \> 200 cells/mm\^3 key exclusion criteria: * anticipated to start hiv-1 therapy during the study period * active participation in another study of investigational or approved art agents * a new acquired immunodeficiency syndrome (aids)-defining condition diagnosed within the 30 days prior to screening * participants with positive hepatitis c antibody at screening * chronic hepatitis b virus (hbv) infection * active, serious infections (other than hiv-1 infection) requiring parenteral antibiotic or antifungal therapy within 42 days prior to day 1 (baseline) note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: hiv-1 infected adults treatment naive
treatment trial for acute central serous chorioretinopathy

Conditions: Acute Central Serous Chorioretinopathy

Summary: central serous chorioretinopathy (csc) is a relatively frequent eye disease in younger patients. it is characterized by serous detachment of the neurosensory retina with or without serous detachment of the retinal pigment epithelium (rpe), which can cause vision drop, image distortion, loss of color and contrast vision. although nonfoveal focal leakage can be treated with traditional laser photocoagulation, but it has the side effects of causing rpe atrophy, scotoma, or secondary cnv. photodynamic therapy (pdt) is another effective treatment but it's more than most families can afford to pay because of the high cost, what's more, it is accompanied with side-effects, such as choroidal ischemia, retinal pigmental epithelium (rpe) atrophy and rpe rip. to date there is no international consensus on the optimal treatment of csc many retrospective studies suggest that micropulse laser (mpl) therapy may also be effective without obvious complications in this disease. the purpose of this study is to evaluate the effect of micropulse laser (mpl) on acute central serous chorioretinopathy compared with the traditional laser coagulation.

the study is a prospective randomized controlled trial about 577nm micropulse laser versus traditional laser coagulation therapy on acute central serous chorioretinopathy. the primary outcome measures is the proportion of eyes with complete absorption of subretinal fluid 3 months after treatment.

Eligibility criteria:
inclusion criteria: 1. onset for the first time, as an episode duration of less than 6 months 2. patient was between 18 and 55 years of age 3. the presence of subretinal fluid(srf) involving the macula and detected by use of optical coherence tomography (oct) 4. active fluorescein leakage during fluorescein angiography (fa) 5. best corrected visual acuity (bcva) more than 0.1, and less than 1.0 exclusion criteria: 1. previous pdt, focal photocoagulation, intravitreal injections of anti-vascular endothelial growth factor, or ocular surgery 2. other macular abnormalities such as choroidal neovascularization(cnv) or polypoidal choroidal vasculopathy(pcv) 3. retinal atrophy 4. pregnancy 5. inability to obtain photographs or to perform fa 6. use of steroid systemically or topically in the last 6 months

Keywords: csc micropulse laser traditional laser
stepped care for depression in heart failure

Conditions: Heart Failure; Depressive Disorder, Major

Summary: this study evaluates stepped care for depression in patients with heart failure (hf). the stepped care intervention consists of individualized cognitive behavior therapy (cbt). half of the participants will receive stepped care and half will receive usual care for depression; all participants will receive heart failure self-care education and support. the primary aims are to determine whether stepped care is superior to usual care for depression, and whether treating depression improves heart failure self-care outcomes.

depression is associated with poor heart failure self-care. good self-care practices, including following dietary recommendations, taking prescribed medications, monitoring symptoms, and regular light exercise have been shown to improve quality of life and survival in persons with heart failure. both cbt and antidepressant medications have been used in previous studies to treat major depression in patients with heart failure. participants in the intervention arm in this trial will start with cbt. those who do not improve very much within the first 5-10 weeks of cbt may also be referred to their own physician to discuss antidepressant medications. heart failure self-care education and support will be provided after the first 8 weeks of the depression intervention. the study will determine whether people with heart failure benefit more from self-care education and support after their depression has been treated with a stepped care intervention, as compared to usual care for depression as provided by primary care providers.

Eligibility criteria:
inclusion criteria: 1. stable, clinically-documented new york heart association (nyha) class i-iii heart failure. 2. current major depressive episode. 3. baseline beck depression inventory (bdi-ii) score 14 or greater exclusion criteria: 1. dementia or other significant cognitive or communication deficits 2. terminal illness other than hf 3. insurmountable logistical barriers to participation 4. age less than 25 years 5. current clinically significant substance abuse, bipolar disorder, schizophrenia, or other psychotic disorder 6. high risk of suicide 7. current participation in non-study psychotherapy for depression or other psychiatric conditions 8. initiation or modification of antidepressant medication treatment within past two months 9. renal or hepatic conditions that would preclude the use of antidepressants.

Keywords: heart failure depressive disorder, major cognitive therapy self-care
effects of holistic spinal fascial mobilization in neck pain

Conditions: Neck Pain

Summary: this study aims to determine the effects of holistic spinal fascial mobilization on pain, range of motion and function in patients with chronic neck pain so that we can have the best treatment option for patients with chronic neck pain, the duration will be 10 months, purposive sampling will be done, subject following eligibility criteria from bahawal victoria hospital bahawalpur, were allocated in two groups, a baseline assessment was done, group a participants were given conventional treatment along with fascial mobilization, group b participants were given conventional treatment, numeric pain rating scale(nprs), neck disability index(ndi) and goniometry for a range of motion,3 sessions per week were given, data was analyzed by using spss version 25.

chronic neck pain is one of the most common musculoskeletal disorders among the general population. like a muscular spasm of the neck that can cause neck pain, fascial adhesions are also a common cause of neck pain. fascia is a form of connective tissue that is made up of collagen, surrounds the body parts, and also resists tissue tensile load. there is huge literature regarding the management of neck pain and yet after decades of research, there are gaps in treatment options. in the modern age of health care, it is a common goal of every health care to make patients self-sufficient as early as possible. the self-care models have tremendous advantages. the current study aims to determine the effects of holistic spinal fascial mobilization on pain, range of motion, and function in patients with chronic neck pain. all treatment methods were employed to see if they improve the ranges accompanying pain and disability.

Eligibility criteria:
inclusion criteria: * both genders. * age 25-60 years. * nprs \>4 * subjects diagnosed with chronic neck pain with minimum 3 months of chronicity * subjects without any other pathology affecting the neck and upper limb. exclusion criteria: * subjects with a history of vertebro-basilar artery insufficiency * any bony, soft tissue, systemic disease, fever, malnutrition or tumor. * surgery

Keywords: fascia range of motion mobilization