Kornimate/medical-research-clean huggingface dataset:
effectiveness of sorbion in the treatment of venous leg ulcers the protocol elements

Conditions: Venous Wound Ulcers

Summary: to follow the effectiveness of sorbion dressing in the treatment of highly exuding venous leg ulcers.

wounds will be assessed for inclusion into the study, digital images of the wound will be taken, wound will be cleansed, a sorbion dressing will be placed on wound and a cover dressing with be used to keep in place. the wound will be assessed and a dressing change will take place weekly for 4 weeks. at the final visit a final wound evaluation will be done.

Eligibility criteria:
inclusion criteria: * venous leg ulcer exclusion criteria: * pregnant females
the effect of acupressure in improving constipation among inpatients in neurology departments

Conditions: Constipation

Summary: as a form of non-invasive auxiliary care, traditional chinese medicine acupressure can prevent constipation, reduce medication for constipation, save medical costs, and alleviate constipation among inpatients in neurology departments, as well as improve patients' general ease and comfort of defecation, thereby improving their quality of life. it also provides clinical nursing staff with a more effective, safer, and more comfortable auxiliary method of preventing constipation, and can be used as a reference for the nursing of such patients.

background: constipation is a common problem among geriatric patients and in neurology departments. however, using stool softeners and enemas yield only temporary effects and may even lead to alternating constipation, diarrhea, and metabolic disorders. because of its non-invasive nature, acupressure can be used as adjuvant therapy of integrated traditional chinese and western medicine to prevent constipation among inpatients in neurology departments. it is necessary to verify that acupressure can be applied to avoid and alleviate patients' constipation, improve their comfort, and improve their quality of life. objective: to explore the effect of acupressure in alleviating constipation among inpatients in neurology departments.method: a randomized controlled two-group pre-test and post-test experiment design were adopted in this study; neurology department inpatients were randomly assigned to either the experimental group, which comprised 64 subjects receiving acupressure on three acupoints (tianshu, st25: stomach meridian 25; zhongwan cv12: conception vessel 12; qihai cv6: meridian vessel 6) or the control group which comprised 64 subjects receiving routine nursing and fake acupressure. the research tools included the bristol stool form and constipation assessment scale.

Eligibility criteria:
inclusion criteria: 1. age ≥ 20 years old 2. established diagnosis of stroke (ischemic, hemorrhagic acute phase) 3. nihss 1-20 points 4. undiagnosed within three months before admission with intestinal disease and no rectal resection 5. meeting the diagnostic criteria for functional constipation (rome iv). exclusion criteria: 1. abdominal surgery or abdominal radiotherapy within three months 2. abdominal cancer including liver, large intestine, lymph, and pelvic cavity, etc., 3. massive ascites 4. there are implants in the abdominal cavity, such as v-p shunt, l-p shunt, capd, etc.

Keywords: acupressure, constipation,
pain inflammation and cannabis in hiv

Conditions: HIV Infections; Neuropathic Pain; Cannabis

Summary: this study will examine how medical cannabis use affects neuropathic pain, inflammation and adverse events in people living with hiv (plwh) with neuropathic pain. the investigators will observe how varying ratios of thc (tetrahydrocannabinol) and cbd (cannabidiol) in medical cannabis impact neuropathic pain, inflammation and adverse events.

this study will examine how medical cannabis use affects neuropathic pain in plwh with neuropathic pain. the investigators will enroll adults with hiv who have a) neuropathic pain, b) are actively certified for medical cannabis, and c) intend to have soft gel capsule products dispensed at vireo (medical cannabis dispensary). the investigators will observe how pain and inflammation change in participants after they are randomized to receive high thc:low cbd product, an equal thc:cbd product, a low thc:high cbd product, or placebo by our collaborator in a separate study. over 14 weeks, data sources will include questionnaires, blood samples, urine samples; medical, pharmacy, and prescription monitoring program (pmp) records. the primary independent variable will be type of medical cannabis product dispensed at dispensary, and the primary outcome will be self-reported pain.

Eligibility criteria:
inclusion criteria: -\>=18 years old * diagnosis of hiv * fluency in english * active certification for medical cannabis * icd-10 diagnosis code for neuropathic pain, or neuropathic pain in problem list of electronic medical record, or neuropathic pain per medical cannabis certification form, or neuropathic pain questionnaire-short form\>0 exclusion criteria: * inability to provide informed consent * inability to complete 14 weeks of study visits * medical cannabis use within 14 days of enrollment, and no medical cannabis dispensed within 30 days of enrollment * unique pain symptoms (e.g., multiple sclerosis, rheumatoid arthritis) * terminal illness * current or prior psychotic disorder * unregulated cannabis use in the past 14 days; opioid or cocaine use in the past 30 days * dispensed opioids within 30 days * non-steroidal anti-inflammatory use within 7 days prior to enrollment * steroid use within the past 14 days with duration of therapy \>=21 days * covid vaccination or booster within 14 days of screening * active or acute cardiac disease based on clinician chart review.
effect of simvastatin treatment on vaso-occlusive pain in sickle cell disease

Conditions: Sickle Cell Disease

Summary: the purpose of this study is to determine whether simvastatin is effective in reducing the frequency and intensity of vaso-occlusive pain episodes in patients with sickle cell disease.

sickle cell disease (scd) is characterized by recurrent vaso-occlusive episodes and a chronic inflammatory state leading to progressive multi-organ injury. the pathophysiology of scd is related to endothelial dysfunction driven largely by impaired nitric oxide (no) homeostasis and chronic inflammation. through multiple mechanisms, including upregulation of no, statins have been shown to confer protection from endothelial injury, independent of their cholesterol-lowering properties. by inhibiting inflammation and several common pathways leading to vascular damage,simvastatin may help prevent the acute and chronic complications of scd. the objective of this study is to determine whether our preliminary results showing simvastatin-associated reductions in plasma markers of vascular injury will translate into a reduction in vaso-occlusive pain episodes in patients with scd. a web-based, smartphone-accessible electronic pain diary will be used to monitor frequency and intensity of vaso-occlusive pain in scd patients treated with a single daily dose of simvastatin.

Eligibility criteria:
inclusion criteria: * sickle cell disease (hbss or s/β0 thalassemia) * ≥ 3 vaso-occlusive pain episodes in the year prior to enrollment * age ≥ 10 years * weight \> 30 kg exclusion criteria: * creatine kinase (ck) \> unl * total cholesterol \< 90 mg/dl, or triglycerides \<30mg/dl * renal dysfunction (creatinine \> 1.5-fold unl) * hepatic dysfunction (alt \> 2-fold unl) * treatment with drugs having known metabolic interactions with statins within the past 30 days * vaso-occlusive pain requiring hospitalization within past 30 days * red blood cell transfusion within the past 30 days * pregnancy/lactation * musculoskeletal disorder associated with an elevated ck level * past or present history of substance abuse (alcohol, cocaine, amphetamines, heroin) * chronic pain caused by avascular necrosis of the bone (avn) or leg ulcers, and pain due to trauma or causes other than scd. * major cognitive or neurological impairments that may hamper the ability to use the smartphone or complete the electronic pain diary in this study

Keywords: sickle cell disease statins vaso-occlusive pain inflammation biomarkers
the effect of regional anaesthesia and genetic factors in the development of chronic pain following total knee arthroplasty

Conditions: Arthroplasty, Replacement, Knee; Chronic Pain Post-Proceduraal

Summary: the study aims to assess the effect of spinal anaesthesia against a general anaesthesia with a femoral block, with respect to the incidence of chronic pain following a total knee replacement. it will also focus on genetic factors and their influence on chronic pain.


Eligibility criteria:
inclusion criteria: * patients able to undergo a total knee arthroplasty exclusion criteria: * age more than 75 years * known case of chronic pain syndromes * arthroplasty not due to osteoarthritis * sensitivity to any drugs used in protocol

Keywords: arthroplasty, knee chronic pain
robotic mirror therapy system for functional recovery of hemiplegic arms

Conditions: Stroke

Summary: the investigators developed a real-time 2-axis mirror robot system as a simple add-on module for conventional mirror therapy using a closed feedback mechanism, which allows for real-time movement of the hemiplegic arm. the investigators conduct a case study for stroke patients with a two-dimensional mirror robot for 30 min per day for two weeks (10 sessions). for the conventional mirror therapy group, the investigators prepared the tasks for fine motor training.

the investigators conduct a case study for stroke patients with a two-dimensional mirror robot for 30 min per day for two weeks (10 sessions). for the conventional mirror therapy group, the investigators prepared the tasks for fine motor training. these tasks included more complicated tasks so that the participants would be interested in the tasks without the robot system. before and after 10 sessions of the therapy, the investigators conduct functional evaluations: the fugl-meyer assessment scale of the upper extremity (fma-ue), the modified ashworth scale, the modified barthel index of upper extremity (mbi-ue: personal hygiene, bathing, feeding, and dressing), and the jebsen hand function test, hand power measurement, and hemispatial neglect test (line bisection test and albert's test) with the same occupational therapist. the motor evoked potential was measured for the patients without the history of brain surgery or seizure. the investigators selected a thumb finding test (tft) among various tools for assessing proprioception, because tft is widely used and reliable. the tft can be assessed, after confirming normal proprioception in the unaffected arm, by the patient touching the nose with their eyes closed while the examiner lifts the affected arm to eye level. the patient is then asked to grasp the thumb of the affected hand with the unaffected hand, and this is repeated. the examiner then places a hand over the patient's eyes and raises the patient's affected hand to well above the patient's head. the patient is then asked to grasp the thumb as before.

Eligibility criteria:
inclusion criteria: * over 18 years old * supratentorial stroke diagnosed between 4 months and 6 years ago * upper-limb hemiplegia with medical research council grade 2 or less. exclusion criteria: * severe spasticity with modified ashworth scale of grade 3 or more; * mini-mental state examination score less than 12 * global or sensory aphasia.

Keywords: mirror therapy proprioception rehabilitation stroke hemiplegia
multi-center study of new medications to treat vaginal infections

Conditions: Vaginal Infection

Summary: the purpose of this study is to evaluate the safety and efficacy of terconazole gel in the treatment of vaginal infections


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of vaginal infection that is confirmed by laboratory testing and: * capable of providing written informed consent or assent * currently not menstruating and not anticipating menses during treatment * if heterosexually active, subject must be post-menopausal for ≥ 1 year, surgically sterile, or practicing an acceptable form of birth control * negative pregnancy test * other criteria as identified in the protocol exclusion criteria: * other infectious causes of vulvovaginitis * subject has recently used, or is expected to require the concomitant use of prohibited medications/products * nursing mother * use of any investigational drug within 30 days of enrollment * history of hypersensitivity to any ingredient/component of the formulations * other criteria as identified in the protocol
hemodynamic effects during exercise in patients with pulmonary hypertension receiving sildenafil

Conditions: Hypertension, Pulmonary

Summary: to study hemodynamic effects of sildenafil during exercise in patients with pulmonary hypertension.


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature (appendix informed consent form) * ph class i (pah) or iv (cteph) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmhg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmhg during baseline measures at the diagnostic right-heart catheterization exclusion criteria: * resting partial pressure of oxygen \<8 kilopascal at zürich altitude on ambient air * exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study * inability to follow the procedures of the study * patients who take nitrates * other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)

Keywords: hypoxia exercise hemodynamics vasodilative drug
influenza and the heart an investigation into the acute and lasting cardiac effects of influenza infection

Conditions: Influenza; Cardiovascular Complication

Summary: "influenza and the heart: an investigation into the acute and lasting cardiac effects of influenza infection" the investigators aim to assess the mechanisms for cardiovascular disease in patients suffering an acute influenza infection. the project will be carried out by creating a prospective clinical cohort study of consecutive patients hospitalized at herlev \& gentofte university hospital with a laboratory confirmed influenza.


Eligibility criteria:
inclusion criteria: * all patients hospitalized at herlev \& gentofte university hospital with a laboratory-confirmed diagnosis of influenza * \> 18 years of age exclusion criteria: * persons not able to cooperate * persons unable to understand and sign "informed consent" * pregnancy * persons simultaneously positive with covid-19
oxygen reserve index to reduce hyperoxia

Conditions: Hyperoxemia

Summary: excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. hyperoxia is very common in general anesthesia settings. even though there are concerns in using excessive oxygen during general anesthesia, the optimal fraction of inspired oxygen (fio2) for general anesthesia is not well studied. the oxygen reserve index (ori) is a parameter which can evaluate partial pressure of oxygen (pao2) rating from 0 to 1. there are growing evidences in ori that it might be helpful to reduce hyperoxia in critically ill patients in the intensive care unit, as well as in general anesthesia. the aim of this study is to evaluate efficacy of oxygen reserve index to reduce hyperoxemia in major abdominal surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective major abdominal surgery expected to last more than 2hours. * patients who are scheduled for invasive arterial cannulation during surgery. exclusion criteria: * abnormal pulmonary function test * pregnancy * saturation of oxygen (spo2) is below 92% in room air
a study of ilb2109 in patients with advanced solid malignancies

Conditions: Advanced Solid Tumor

Summary: this is a multicenter, open-label, phase ia study to evaluate the safety, tolerability and preliminary efficacy of ilb2109, a a2a receptor antagonist, in patients with locally advanced or metastatic solid malignancies.

this is a two-part study consists of dose escalation and dose expansion. the dose escalation part adopts a 3+3 protocol design and consists of 5 cohorts. based on the data obtained from the escalation study, selected cohorts will be expanded to further investigate the safety and efficacy of the study drug. the escalation part consists of a single-dose cycle (cycle 0) followed by multiple-dose cycles (cycle 1 and above). subjects will be assessed for safety and efficacy outcomes at pre-specified time points.

Eligibility criteria:
inclusion criteria: * histologically or cytological confirmed, solid, malignant tumor that is refractory to standard therapy or for which no standard of care regimen currently exists; * at least one assessable tumor lesion according to recist v1.1 in dose escalation part of the study ; at least one measurable tumor lesion according to recist v1.1 in dose expansion part of the study; * eastern cooperative oncology group (ecog) performance status of 0 or 1; * major organ functions are normal, meets pre-specified lab requirements; * females of reproductive age must have a negative serological hcg test during the screening period; * subjects of reproductive age (both male and female) must agree to use contraceptive methods from signing informed consent to 90 days post the last dose; exclusion criteria: * has received any investigational medicinal product or other systemic anticancer treatment within 4 weeks prior to the first dose of study treatment; * unable to take medication orally, or has impaired gi function; * has received systemic glucocorticoids (prednisone\>10 mg/ day or an equivalent dose of another drug of the same class) or other immunosuppressants within 14 days prior to the first dose of study treatment; * has received live, attenuated vaccines within 4 weeks prior to the first dose of study treatment; * has active infection that requires intravenous anti-infective therapy; * history of hiv infection, or other acquired, congenital immunodeficiency disease, or a history of organ transplantation; * history of serious cardiovascular and cerebrovascular diseases; * history of adverse effect from previous antineoplastic therapy that has not returned to ctcae grade 5.0 ≤1; * cerebral parenchymal or meningeal metastasis; * history of ≥ grade 3 irae or ≥ grade 2 myocarditis from previous immune therapy;
clinical application of the apex of the deep cartilage in evaluating the femoral tunnel of the acl reconstruction

Conditions: Anterior Cruciate Ligament Injuries

Summary: with the apex of the deep cartilage (adc) as the symbol, the consistency of the two methods in the postoperatively computed tomography (ct) and microscopic evaluation of the position of the femoral tract of the anterior cruciate ligament (acl) was studied.expected results:p1 and p2, d1 and d2 were positively correlated, and the linear relationship was significant. bland-altman diagram shows a good consistency.

objectives: with the apex of the deep cartilage (adc) as the symbol, the consistency of the two methods in the postoperatively computed tomography (ct) and microscopic evaluation of the position of the femoral tract of the anterior cruciate ligament (acl) was studied. methods: prospective cohort study. fifty-two patients requiring arthroscopic anterior cruciate ligament reconstruction were enrolled in the sports medicine department of peking university third hospital. collect patients' basic information and preoperative conditions. during the operation, the patient's knee was bent 90°, and the center point was positioned according to the intact femoral stump. the horizontal distance from the adc to the anterior bone margin (l1) and the horizontal distance from the center point of the bone tract (l1) were measured by the master, the first aid and the second aid, and the distance from the center point of the bone tract to the lower bone margin (d1) was measured, and the ratio of l1 /l1 was calculated (p1). the horizontal distance from the adc to the anterior bone margin (l2) and the horizontal distance from the center of the bone tract (l2) were measured by three investigators on postoperative ct films, and the distance from the center of the bone tract to the lower bone margin (d2) was also measured, and the ratio of l2 /l2 was calculated (p2). linear regression, pearson correlation and bland-altman analysis were used to compare the consistency between the endoscopic assessment and ct assessment. expected results: p1 and p2, d1 and d2 were positively correlated, and the linear relationship was significant. bland-altman diagram shows a good consistency.

Eligibility criteria:
inclusion criteria: * patients who have isolated acl injury and receive acl reconstruction surgery at peking university third hospital. * with isolated acl injury (an acl injury with no need for surgical repairs to other knee structures). * all participants have no known disorders or diseases other than acl rupture. exclusion criteria: • other injuries affecting movement performance.

Keywords: anterior cruciate ligament computed tomography the apex of the deep cartilage microscopic evaluation
dual rapid hiv & syphilis tests in zambia

Conditions: HIV; Syphilis

Summary: the purpose of this study is to provide evidence on the performance and operational characteristics of commercially available dual hiv/syphilis rapid diagnostic tests (rdts) in zambia for their introduction into antenatal care and other settings.

early detection and timely intervention of pregnant women infected with hiv and/or syphilis is critical. to improve the number of women tested and treated, the centre for infectious disease research in zambia (cidrz) and the ministry of community development, mother and health (mcdmch) this field study will assess the effectiveness of newly developed dual hiv and syphilis rapid diagnostic tests (rdts) manufactured by chembio and standard diagnostics in lusaka district antenatal clinics. the specific objectives of this field performance evaluation of the rapid diagnostics are to determine the antenatal clinic-based performance of dual hiv/syphilis rdts compared to that of current reference standard assays, and to assess the operational characteristics and acceptability of these dual hiv/syphilis rdts to patients and health care providers this cross-sectional study of 3,765 pregnant women will validate the performance of chembio and standard diagnostics dual hiv and syphilis rdts.

Eligibility criteria:
inclusion criteria: * pregnant women attending their first antenatal care visit at a study clinic * 18 years of age or older * willing and able to provide informed consent for study participation exclusion criteria: * prior participation in the study