Kornimate/medical-research-clean huggingface dataset:
improving sleep to reduce risk for substance use disorder

Conditions: Substance Use Disorders; Insomnia; Posttraumatic Stress Disorder

Summary: substance use disorders (suds) are a prevalent and impairing condition, particularly among trauma exposed individuals. the current proposal aims to address the critical need for targeted direct sud prevention in this population by intervening on a novel, malleable risk factor for sud common among trauma-exposed individuals: sleep disturbance. sleep disturbance prospectively predicts the development of sud and may confer risk for sud by increasing stress reactivity, decreasing decision-making abilities, and ultimately promoting substance use to relieve negative affect, a core etiological factor in sud. however, to our knowledge, no experimental studies have determined whether improving sleep leads to reductions in sud risk. as such, the current study will use a randomized controlled trial design to test the effects of brief behavioral treatment for insomnia (bbti) against a waitlist control among a sample of trauma-exposed young adults with poor sleep and risk for sud (n = 60). we aim to determine the direct and indirect effects of condition (bbti vs. waitlist control) on sud symptoms, substance use-related problems, coping motives, and posttraumatic stress symptoms through improvements in sleep. furthermore, we will test direct and indirect effects of condition on theoretically proposed mechanisms underlying the association between sleep disturbance and sud risk (i.e., stress reactivity, cravings in response to stress).


Eligibility criteria:
inclusion criteria: * trauma exposure * current cannabis use * insomnia symptoms * age 18-30 exclusion criteria: * severe substance use disorder * receiving treatment related to sleep or substance use
covid card pilot study to detect antibodies to sars-cov-2

Conditions: COVID-19; SARS-CoV2 Infection

Summary: this study aims to investigate the clinical performance characteristics of the novel point-of-care, semi-quantitative test for sars-cov-2 in the emergency department compared to the gold standard (elisa).

a prospective, non-blinded, non-randomized trial will be conducted at the adult emergency department at the university of maryland medical center and adult urgent care center, which is managed by the department of emergency medicine, located in baltimore, maryland. patients meeting eligibility criteria and who have signed the research informed consent will be enrolled in this study. subject data collected will include demographic information and past medical history. upon enrollment into the study, a study team member will obtain a fingerstick blood sample and a sample of blood obtained during usual care venipuncture. both fingerstick blood and blood from venipuncture will be run on the point-of-care, semi-quantitative test. the test should be expected to result within minutes after the blood sample is added to the agglutinin. an additional tube of blood will be obtained and sent to the local central laboratory for quantitative serum sars-cov-2 antibody testing. additional data will be collected on the reported or documented covid-19 immunization status and reported or documented history of prior covid-19 infection.

Eligibility criteria:
inclusion criteria: 1. adult (age \> 18 years) emergency department patients 2. ed workup includes blood testing 3. confirmed history of vaccination against sars-cov-2 exclusion criteria: 1. known to be pregnant at the time of evaluation 2. incarcerated at the time of evaluation 3. requires the use of an interpreter 4. patient is considered immunocompromised or has any other condition that the investigator feels makes the patient unsuitable for study inclusion. 5. has any other condition that the investigator feels makes the patient unsuitable for study inclusion
rct comparing oagb and long limb roux gastric bypass

Conditions: Obesity

Summary: a prospective multicenter randomized controlled trial to compare the outcomes of one-anastomosis gastric bypass to long biliary limb roux gastric bypass. we plan to enroll up to 500 patients from three different clinics in estonia. outcomes are excess weight loss %, impact on type 2 diabetes, hypertension, hyperlipidemia and obstructive sleep apnea. other outcomes are nutritional deficiencies, occurrence of reflux disease and impact on quality of life. there are planned outpatient visits 1, 5 and 10 years after the surgery to measure the impacts. there are a lot of studies comparing oagb to standard roux gastric bypass but non comparing it to long biliary limb gastric bypass.


Eligibility criteria:
inclusion criteria: * bmi over 35 and obesity related disease * bmi over 40 * age between 18-60 years * agrees to participate in the study exclusion criteria: * age under 18 years or over 60 years * abundant adhesions discovered during the surgery * active upper gastrointestinal ulcer disease * prior bariatric surgery * active symptomatic reflux disease * active psychiatric disease (eg psychosis)

Keywords: oagb long biliary limb roux gastric bypass metabolic surgery obesity
exercise and parkinson's: comparing interventions and exploring neural mechanisms

Conditions: Parkinson Disease

Summary: parkinson disease (pd) is characterized by substantial disability and reduced quality of life, both of which can be attributed in large part to difficulties with walking. evidence suggests that exercise may be an important addition to traditional treatments, particularly with respect to addressing walking problems. in particular, dance and treadmill training have been individually shown to improve walking performance and quality of life. at present it is not clear whether dance or treadmill training have similar effects or if one is superior to the other. furthermore, our understanding of the means by which these exercise interventions convey benefits is extremely limited. this study aims to address these knowledge gaps by directly comparing dance, treadmill training and stretching (control group). the primary area of interest is the effects on gait, with secondary measures of disease severity, balance, and quality of life. the investigators will determine not only the effects of the interventions on walking performance, but will also investigate the effects of the interventions on connections between different parts of the brain and on brain function during imagined walking tasks using functional magnetic resonance imaging (fmri). participants will be randomly assigned to dance, treadmill training, or a stretching/flexibility control group. participants will be assessed over a period of 6 months at 3 different time points. the investigators hypothesize that both dance and treadmill training will lead to improvements in forward walking, but that dance will result in greater improvements in backward walking compared to treadmill training. furthermore, the investigators hypothesize that the tango and treadmill interventions will have different effects of brain function and brain connections. the investigators expect dance to enhance the activity and connections of particular brain regions and treadmill training to enhance activity and connections of different brain regions. the investigators do not expect changes in brain activity or connections in the control group.


Eligibility criteria:
inclusion criteria: 1. diagnosis of parkinson disease 2. at least grade 3/5 strength and normal joint ranges of motion in both legs, 3. vision corrected to 20/40 or better, 4. able to walk independently for 10 feet with or without an assistive device, 5) normal gross somatosensory function in the feet (2-point discrimination, vibration, joint kinesthesia, and light touch), 6) no history of vestibular disease, 7) no evidence of dementia exclusion criteria: 1. medical condition for which exercise is contraindicated, 2. evidence of abnormality other than pd-related changes on brain imaging, 3. history or evidence of neurological deficit other than pd that could interfere, such as previous stroke or muscle disease, 4. history or evidence of orthopedic or muscular problem, 5. failed to pass magnetic resonance imaging screening procedure

Keywords: parkinson disease walking fmri exercise dance treadmill
a randomized, double-blind, placebo- and active-controlled study of the electric current effects of abt-639 on the spontaneous activity of pain sensory receptors in patients with diabetic peripheral neuropathy

Conditions: Diabetic Neuropathic Pain

Summary: people with diabetes can, over time develop nerve damage throughout the body with symptoms such as pain, tingling, or numbness (loss of feeling) in the hands, arms, feet and legs.


Eligibility criteria:
inclusion criteria * subject is between the ages of 18 to 75 years with a diagnosis of diabetes mellitus and must have a diagnosis of painful distal symmetric diabetic polyneuropathy and presence of ongoing pain due to diabetic peripheral neuropathy for at least 6 months. * subject must have an average score of greater than or equal to 4 on the 24 hour average pain score (0-10 numerical rating scale) collected over approximately 7 days prior to the baseline visit. exclusion criteria * subject has clinically symptomatic neuropathic pain conditions that can not be distinguished from diabetic neuropathic pain or interfere with the pain assessments of diabetic neuropathic pain. * a subject has newly diagnosed or clinically significant medical conditions or mental disorders that would preclude participation or would interfere with diabetic neuropathic pain assessments or other functions. * subject has clinically significant abnormalities in clinical laboratory tests.

Keywords: diabetic peripheral neuropathy
comparing fixed-bearing versus mobile-bearing prosthesis in total knee arthroplasty: a prospective randomized trial

Conditions: Osteoarthritis

Summary: the purpose of this study is to determine which prosthesis is better in total knee arthroplasty

theoretical advantages of mobile-bearing devices led surgeons to use these prostheses instead of fixed-bearing devices as traditional implants. this study was designed to compare fixed-bearing versus mobile-bearing prosthesis in total knee arthroplasty through a five-year follow-up.

Eligibility criteria:
inclusion criteria: * patients with expected primary total knee arthroplasty exclusion criteria: * mediolateral instability * infective arthritis * severe deformity * revision

Keywords: total knee arthroplasty fixed-bearing mobile-bearing
molecular mediators of nerve injury signaling

Conditions: Diabetes; Nerve Injury; Chronic Neuropathic Pain

Summary: specific proteins and other signaling molecules are increased and decreased following nerve injury. some of these are important in producing pain or explaining why pain persists after traumatic nerve injuries or in disease states such as diabetes. in this study, the investigators hypothesize that it is possible to detect changes in specific signaling molecules and that these will provide insights into novel treatment strategies. the patients to be included are those who are undergoing the removal of tissue during surgery. the tissues that would otherwise be discarded will be included in the study as appropriate.


Eligibility criteria:
inclusion criteria: * patients undergoing surgery where tissue removal is anticipated exclusion criteria: * age younger than 18
validation of the hebrew version of the montreal affective voices.

Conditions: Parkinson's Disease; Depression

Summary: today, no non-verbal auditory stimuli that assess mental processing are available in israel. the goal of this study is to make available a validated set of auditory stimuli in israel. we created a computerized hebrew version of the montreal affective voices (mav). the mav is a novel tool for assessing mental processing. the mav consists of 90 nonverbal affect bursts corresponding to nine different emotions (such as anger, fear, happiness etc.) recorded by ten different actors. the uniqueness of these affective bursts is that they do not contain verbal context, but rather express affective moods using the vowel /a/ (as in "apple"). in this study, the investigators will verify the new hebrew version of mav in healthy control groups. next, the investigators will compare the mental processing ability in young vs. old population, using the mav test. in addition, the investigators will assess mental processing in two pathologic study groups (parkinson's disease, major depressive disorder) using the mav test. the investigators intend to use the mav tool in future research in parkinson's disease and depression.


Eligibility criteria:
inclusion criteria: * healthy group * parkinson's disease * major depressive disorder * all participants will be competent and willing to give written informed consent. patients over 65 and/or suspected to have a cognitive decline will be tested by the mini-mental test and will be included in the study only if the score is above 26. exclusion criteria: * non-competent or unable to give written informed consent
pattern of non valvular atrial fibrillation in acute ischemic stroke patients at assiut university hospitals

Conditions: Atrial Fibrillation

Summary: pattern of non valvular atrial fibrillation in acute ischemic stroke patients at assiut university hospitals.

percentage of patients with af admitted with acute cerebrovascular stroke at assuit university and correlation between af and severity of stroke at admission and discharge.

Eligibility criteria:
inclusion criteria: * patients presented with acute cerebrovascular stroke aged more than 18 years old. exclusion criteria: 1. patients below 18 years old. 2. patient admitted with cerebral hemohrrage. 3. patients with significant valvular heart disease.
effect of probiotic bacteria on oral candida in frail elderly

Conditions: Candidiasis

Summary: the aim of this study is to investigate the effect of daily intake of the probiotic lactobacillus reuteri on the prevalence and counts of oral candida in frail elderly living in nursery homes.

the aim of the present study was to investigate the effect of a twice daily intake of lozenges containing probiotic lactobacillus reuteri on the prevalence and counts of oral candida in senior residents living in nursery homes. the material consists of 215 elderly persons (range 60 to 102 years) living in 20 different nursery homes in the county of kronoberg, situated in the southern parts of sweden. the subjects were consecutively enrolled after informed consent consisting of verbal and written information directed to the individual as well as to their relatives. the study employed a double-blind randomized placebo-controlled design.

Eligibility criteria:
inclusion criteria: * non-smoking * ability to cooperate with a dental examination and saliva sampling exclusion criteria: * severe chronic disease, malignancies or ongoing medication with immunosuppressive drugs * severe dementia or cognitive impairment
trial measuring the clinical impact of the filmarray® pneumonia panel in critically ill

Conditions: Pneumonia

Summary: the objective of this study is to measure how the use of film-array pneumonia (fa-pneu) on respiratory samples of adult patients suspected of acute care pneumonia in the intensive care unit of saint-luc university hospital can accelerate / improve the initiation of the optimal antibiotic treatment.

the main objective of this trial is to confirm/attest/prove the following statement: the use of the filmarray pneumonia panel on respiratory samples of critically ill suspected with pneumonia, enables a faster microbiological pneumonia diagnosis and an improved therapeutic management of the patient.

Eligibility criteria:
inclusion criteria: * adult patients 18 years, remaining at the intensive care of the saint-luc university hospital * recently transferred from emergency care with community acquired pneumonia of grade 4 suspicion * with a ventilation acquired pneumonia suspicion suspicion will be based on symptoms, clinical, biological and radiological criteria. exclusion criteria: * patients from whom no respiratory sample can be obtained * patients benefitting from palliative care * insufficient volume of the respiratory sample after routine testing to perform the fa-pneu test.

Keywords: pneumonia molecular testing clinical impact filmarray pneumonia
68ga dota-tate pet/ct in somatostatin receptor positive tumors

Conditions: Carcinoid Tumors; Islet Cell (Pancreatic NET); Other Neuroendocrine Tumors

Summary: the primary objective of the study is to evaluate 68ga-dota tate pet/ct for staging and monitoring response to chemotherapy in patients with carcinoid, neuroendocrine tumors, medullary thyroid cancer and other cancers expressing somatostatin receptors.


Eligibility criteria:
inclusion criteria: * greater than 18 years-old at the time of radiotracer administration * provides written informed consent * known diagnosis of net or suspected sstr positive tumors by 111in-octreotide scan, 18fdg-pet, or mri of the abdomen when clinically indicated * karnofsky score greater than 50 or ecog performance status 0-2 * women of childbearing age must have a negative pregnancy test at screening/baseline * able to remain still for duration of each imaging procedure (about one hour) exclusion criteria: * less than 18 years-old at the time of radiotracer administration * pregnant or nursing * serum creatinine \>3.0 mg/dl * hepatic enzyme levels more than 5 times upper limit of normal. * use of any other investigational product or device within 30 days prior to dosing, or known requirement for any other investigational agent prior to completion of all scheduled study assessments. * inability to lie still for the entire imaging time * inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (severe claustrophobia, radiation phobia, etc.) * any additional medical condition, serious intercurrent illness, or other extenuating circumstance that, in the opinion of the investigator, may significantly interfere with study compliance.
screening strategy for asymptomatic sexually transmitted infections (sti) in a cohort of hiv outpatients men who have sex with men (driver)

Conditions: HIV

Summary: comparison of two screening strategies of asymptomatic sexually transmitted infections : routine screening versus screening as reported by the risks taken by the patient, in a cohort of hiv outpatients men who have sex with men. the aim of this study will be create and validate a simple tool for clinicians. a digital tool will be developed will allowed empowerment of hiv-positive men who have sex with men.

main objectives are : create and validate a risk score for stis (driver score) in a population of hiv-positive men who have sex with men (msm). determine the prevalence of asymptomatic stis in a population of hiv-positive msm secondary objectives are : compare 2 screening strategies regarding stis in hiv-positive msm (systematic screening vs screening according to self-declared risk factors) conduct a cost-efficiency analysis of both strategies evaluate patients' knowledge of stis develop a driver digital tool that will be made available to patients on websites, mobile apps... position of the problem : over the past 15 years, a resurgence of symptomatic stis has been observed at both at the global and at the local (french) level. this has been true for gonorrhea since 2008, for syphilis since 2000 and for lymphogranuloma venereum since 2003. the epidemiology of asymptomatic stis has not been studied as thoroughly but asymptomatic carriage of neisseria gonorrhoeae and chlamydia trachomatis as well as latent syphilis account for at least half of cases declared in the past few years. the population of hiv-positive msm is the demographic category with the highest rates of stis. in addition, risky sexual attitudes are on the rise in the msm population in general (in 2010, the french resist network reported that condom use during anal penetrations between males had dropped from 49% in 2008 to 37% in 2010). screening practices are currently center- and healthcare-provider dependant. study will allow a comparison of screening practices thanks to a score that will be built, validated and made available to clinicians and patients. type of study : prospective, non randomized, multicentric and cross-sectional timeline : study duration : 18 months beginning of study : march 2015

Eligibility criteria:
inclusion criteria: * hiv positive outpatients * men who have sex with men * speaking, literate french * having a french health insurance or an equivalent * asymptomatic for a sti the appointment day exclusion criteria: * men who never had sex with men * protected adults (adults under guardianship) * have a sti symptom ( anal discharge, urethritis, proctitis, chancre, rush)

Keywords: hiv-positive msm (men who have sex with men) asymptomatic sexually transmitted infections screening
a safety and cognitive function study of evp-6124 versus placebo in subjects with nicotine dependence

Conditions: Nicotine Dependence; Smoking Cessation

Summary: this study is designed to evaluate the initial evidence for efficacy of the investigational medicine, evp-6124, to improve smoking cessation outcomes with and without a standard taper of nicotine replacement therapy (nrt) in healthy nicotine dependent smokers


Eligibility criteria:
inclusion criteria: * self-report of smoking an average of ≥10 cigarettes/day for 6 months and expired carbon monoxide (co) ≥10 parts per million (ppm) or urine cotinine ≥ 100 ng/ml at screening or self-report of smoking an average of 5-9 cigarettes/day for 6 months and a urine cotinine ≥30ng/ml at screening * have a negative urine drug screen at screening * fertile, sexually active subjects (males and females) must use an effective method of contraception from the first dose of study drug and for 3 months after the last dose of study drug * if female and capable of conception, must have a negative urine human chorionic gonadotrophin (hcg) pregnancy test at screening and day 1 exclusion criteria: * have unstable medical illness with hospitalization for treatment likely within 6 months * have life-threatening arrhythmia, cerebrovascular or cardiovascular event within 6 months of enrollment * have liver function tests elevated \>2.5 times the upper limit of normal range * have a tumor or a seizure disorder * currently using other tobacco- or nicotine-containing products and unwilling to try to quit * have a 6-month history of substance use disorder other than nicotine or caffeine or major depressive disorder * have a history of multiple adverse drug reactions * non-response (past 3 months) to nicotine replacement therapy (nrt) \>20 mg/day, bupropion \>150 mg/day, or varenicline 2 mg/day for ≥4 weeks * use of excluded concomitant medications * hospitalization for any reason within 30 days of screening * use of any investigational drug or device within 30 days of screening * have clinically significant abnormal serum electrolytes * have insufficiently controlled diabetes mellitus * have renal insufficiency (serum creatinine \>1.8 mg/dl) * malignant tumor within the last 5 years, with the exception of squamous and basal cell carcinoma or cervical carcinoma in situ * have a clinically significant cardiovascular abnormality on the screening ekg * lifetime history of schizophrenia, bipolar disorder, post-traumatic stress disorder, bulimia, organic mental disorder, dementia, pervasive developmental disorder * have untreated, clinically significant hypothyroidism or hyperthyroidism * have a positive self-report of human immunodeficiency virus infection * females who are pregnant or nursing * any experimental drug currently or within 30 days before baseline * have a serious risk of suicide * have a screening electrocardiogram (ecg) with a corrected qt (qtc) interval using bazett's formula \>450 msec for males and \>470 msec for females or the presence of any clinically significant cardiac abnormalities