Kornimate/medical-research-clean huggingface dataset:
neurodevelopmental outcomes in children: strengthening the caregiver-child story

Conditions: Food Insecurity; Depression; Anxiety

Summary: the main goal of this research is to help families who are experiencing food insecurity (fi) and help mothers with depression. the next goal is to provide other resources to help with household needs like rent or utility assistance, health insurance, anxiety, and depression. our theory is that helping with food insecurity, household needs, and emotional health will help children and families.

aim 1: implement a refined mental health (mh) intervention in caregivers of hospitalized children: sessions with a behavioral health clinician (bhc) with more individualized support based on caregiver-child needs, instruction on caregiver-child bonding, and a streamlined handoff to a community mh provider. follow-up outcomes include caregiver mh and caregiver-child attachment (survey) and child development (electronic health records, ehr). aim 2: execute an enhanced intervention for fi. all families who screen positive for fi will still receive assistance with public benefit enrollment and access to local food pantries. families with additional needs will receive support for 10 additional non-medical drivers of health (nmdh). assistance will be provided by onsite houston food bank (hfb) community referral specialists. follow-up outcomes include enrollment in public/community resources and food security status (survey).

Eligibility criteria:
inclusion criteria: * caregivers of young children (0-36 months of age) hospitalized at texas children's hospital on acute care units. * english or spanish speaking caregiver. * age of caregiver ≥ 18 years old. * hospital day 2 or later of patient admission. exclusion criteria: * caregivers who do not have primary custody * children in cps custody * caregivers who live outside of texas (due to lack of houston food bank resources outside of texas) * previous enrollment in this study. * patient is in the process of being discharged/observation status administration. * caregiver is not the primary caregiver.
multimodal diagnostic assessment of cerebral gliomas with fet & fch pet/ct, and magnetic resonance imaging/spectroscopy

Conditions: Glioma

Summary: the aim of this study is to establish the diagnostic value of o-(2-\[18f\]-fluoroethyl)-l-tyrosine (fet) pet-ct, \[18f\]-fluorocholine (fch) and magnetic resonance imaging (mri) combined with magnetic resonance spectroscopy (mrs) in patients with suspected cerebral glioma using neuronavigated biopsies with histopathological analysis as reference.

the objectives of the study are: * to demonstrate if the multimodal approach, combining the morphological aspect of the mri with the metabolic aspect of the tumor with magnetic resonance spectroscopy (mrs) and o-(2-\[18f\]-fluoroethyl)-l-tyrosine (fet) or 18f\]-fluorocholine (fch) pet/ctthe fch allows to improve the location of a active metabolic tumor and its impact on the ideal choice of sampling biopsy. * to underline the differences and similarities between mrs and 18f\]-fluorocholine pet / ct in the assessment of metabolism of the choline. to establish the diagnosis value of both methods, separately and in combination. * to determine which examinations are useful and complementary for the diagnosis and the management of gliomes. fet combined with mrs may be a powerful, widely applicable new method to improve the diagnosis of cerebral gliomas. the extent to which fch and mrs provide similar information is not known precisely and this study will establish their respective diagnostic value in differentiating tumoral from non-tumoral tissue.

Eligibility criteria:
inclusion criteria: * suspicion of intracerebral glioma on mr * men of women * age \>18, no upper limit as long as a biopsy or intervention is foreseen exclusion criteria: * need of rapid intervention in \<2 weeks * previous neurosurgical intervention (biopsy, shunt, etc.) or any other cerebral treatment

Keywords: glioma, diagnosis imaging positron emission tomography magnetic resonance imaging magnetic resonance spectroscopy
study to evaluate real-world pharmacoeconomics of panitumumab in metastatic colorectal cancer patients

Conditions: Colorectal Cancer Metastatic

Summary: this is a phase iv multicenter trial to evaluate real-world health outcomes and economic impact of panitumumab versus standard-of-care (soc) in the treatment of patients with chemotherapy-refractory metastatic colorectal cancer (mcrc). the study will enable real-life health economics and outcome research (heor) to assess the impact of panitumumab in the quebec population. the primary objective is to evaluate real-world health outcomes and economic impact of panitumumab in the treatment of patients with chemotherapy-refractory mcrc in comparison with soc. the secondary objectives are to confirm survival data, to assess the quality of life of patients and to assess the health care resource utilization of patients. patients with a mutated kras gene will be treated with standard-of-care (soc) and patients with a non-mutated (wild type) kras gene will be treated with panitumumab. during the course of the study, data will be collected on quality of life and work productivity. patients will be asked to fill a set of questionnaires at their recruitment in the study and at every 3 months after treatment initiation.


Eligibility criteria:
inclusion criteria: * patients with a histologically confirmed diagnosis of mcrc. * immunohistochemical evidence of egfr expression. * ecog performance status of 0, 1 or 2. * patients refractory to fluoropyrimidine, oxaliplatin, and irinotecan chemotherapy regimens * patients with a wt kras scheduled to receive panitumumab as a single agent for the third-line treatment of mcrc or patients with a mt kras scheduled to receive soc for third-line treatment of mcrc. * signed and dated irb-approved informed consent document. * ability to read and understand english or french. * 18 years of age or older.
evaluation of using different screwed abutment height

Conditions: Bone Loss

Summary: a prospective randomized controlled clinical trial will be conducted. study groups will be assigned as described above. the patients will be randomly divided into two groups in order to study the influence of prosthetic screw abutment in marginal bone loss (mbl) around bone level tapered implants (blt® roxolid® slactive® guided implants, straumann dental implant system, institut straumann ag, basel, switzerland).

48 patients will be selected with partial edentulism in the maxilla or mandible, requiring two dental implants in the posterior areas (molars and premolars). each patient will be randomly allocated in one of the two groups: test group (n=36) or control group (n=12) and all the implants will be placed by residents of the international master in oral surgery and master in periodontics of the same university. study groups group 1: two stage approach (cover screw in first surgery and healing abutment in second surgery) (12 patients) group 2: one stage approach (healing cap over trans-epithelial abutments) (36 patients).two subgroups according to different trans-epithelial height abutment: * subgroup 2.1: screw-retained abutment of 1 mm height (18 patients) * subgroup 2.2: screw-retained abutment of 2.5 mm height (18 patients) clinical parameters and outcomes * three-dimensional volumetric changes in hard and soft tissues (cone-beam computed tomography superposed with digital cast models). * marginal bone level (mbl) change: standardized intraoral periapical x-rays will be taken on the day of surgery, 4, 6, 12, 24 and 36 months following surgery. * probing depth, bleeding on probing and keratinized mucosa width will be measured in the follow-up visits in 3 different points in buccal (mesial, center and distal). * vas scale: the visual analog scale or visual analog scale (vas).

Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. overall, healthy subjects 3. females and males of at least eighteen-years 4. requiring a minimum of two implants (molar and/or premolar teeth) 5. adequate oral hygiene (less than 15% fmps) 6. able to follow instructions and attend a regular compliance 7. enough bone to place a standard implant of 4.1 mm diameter. exclusion criteria: 1. acute local infection 2. occlusal overload with parafunctional activity (assessed clinically) 3. large occlusal discrepancies 4. untreated periodontal disease assessed by socransky et al. parameters (≥2mm clinical attachment loss in two consecutive visits within 1 year) 5. smokers (more than 10 cigarettes/day) 6. drug and/or alcoholic dependencies 7. medical conditions contraindicating implant surgery 8. history of head and/or neck radiation 9. bisphosphonate therapy

Keywords: bone loss dental implant bone implant interface peri implant endosseous healing dental implant abutment
rotational stability after nanoflex collamer toric intraocular lens implantation in astigmatic patients

Conditions: Astigmatism

Summary: this study aims to assess the rotational stability of the new collameric nanoflex toric intraocular lens (t-iol) by staar inserted in astigmatic patients after cataract surgery. the purpose of this study is also to determine whether the use of a toric intraocular lens (t-iol) improves visual acuity.

a good rotational stability of toric intraocular lenses (t-iol) allows an accurate refractive correction. however, many aspects -both pre-operative and post-operative- can interfere causing t-iol rotation and misalignment. complete preoperative ocular evaluation is performed including slit-lamp examination, uncorrected distance visual acuity (udva), best-corrected visual acuity (bcva), javal keratometry, corneal scheimplug tomography (pentacam), optical biometry (iol master), goldman applanation tonometry and fundus evaluation through dilated pupils. the spherical iol power is calculated considering the axial length obtained with optical biometry, the magnitude of astigmatism derived from javal keratometry and the steepest axis obtained with corneal tomography. the power of the toric iol is determined with the online staar toric iol calculator. the reference landmarks are also marked preoperatively with a sterile methylene blue fine point pen. the marking is rechecked in the operating theatre with the electronic toric marker asico. postoperative evaluation for iol alignment and rotational stability is performed with slit-lamp photography on dilated pupils. images are captured with haag streit slit lamp bq 900 and are evaluated with the image-analysis software protractor (staar).

Eligibility criteria:
inclusion criteria: * patients of 60 years of age ore more * cataract * corneal astigmatism of 1 diopter (d) or more exclusion criteria: * primary or secondary pathological conditions of the cornea * zonular fibres pathologies (phacodonesis, pseudoexfoliation syndrome) * irregular astigmatism (corneal scar, keratoconus, pterygium) * traumatic cataract * previous ocular surgery * complications during cataract surgery
a multicenter randomized open-label study of diammonium glycyrrhizinate enteric-coated capsule plus dxm versus dxm in treatment of itp

Conditions: Immune Thrombocytopenia

Summary: the project was undertaking by qilu hospital of shandong university in china. in order to report the efficacy and safety of diammonium glycyrrhizinate enteric-coated capsule plus high-dose dexamethasone for the treatment of adults with newly-diagnosed primary immune thrombocytopenia (itp).

the investigators anticipate to undertaking a parallel group, randomised controlled trial of 106 itp patients. one part of the participants are randomly selected to receive diammonium glycyrrhizinate enteric-coated capsule orally at a dose of 150mg tid for 3 months), combining with dexamethasone (given orally at a dose of 40 mg qd for 4 days). the others are selected to receive high-dose of dexamethasone alone. patients who do not respond to the treatment may receive another cycle of high-dose dexamethasone therapy with an interval of 10 days. platelet count, bleeding and other symptoms were evaluated before and after treatment. adverse events are also recorded throughout the study. the purpose of this study is to report the efficacy and safety of diammonium glycyrrhizinate enteric-coated capsule combining with high-dose dexamethasone therapy for the treatment of itp.

Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria for immune thrombocytopenia; * untreated hospitalized patients or patients from the clinic, may be male or female, between the ages of 18\~ 80 years; * to show a platelet count \<30 \* 10\^9/l, or with bleeding manifestations, or both; * willing and able to sign written informed consent * itp patients with hepatitis virus infection or itp patients with abnormal liver function at the time of enrollment, i.e., itp patients with indications for diammonium glycyrrhizinate enteric-coated capsule, should be separately stratified. exclusion criteria: * secondary thrombocytopenia; * severe immune-deficiency; * active or previous malignancy; * hiv virus infection, tuberculosis, or other active infection (sepsis, pneumonia, or abscess); * pregnancy or lactation; * diabetes; * hypertension; * cardiovascular diseases; * severe kidney function impairment; * psychosis; * osteoporosis; * inflammatory bowel disease or gastric disease; * arterial or venous thromboembolism within the 6 months before screening or patients who required anticoagulant treatment; * an organ or haematopoietic stem-cell transplantation; * neutrophil count of less than 1500 cells per mm³; * glycosylated haemoglobin less than 8%; * partial thromboplastin time 1∙5 times or less the upper limit of normal (uln); •clinical electrocardiogram changes; * history of primary immunodeficiency; * neoplastic disease within the past 5 years; * corrected qt interval greater than 450 ms for men and greater than 470 ms for women; * substance misuse within the previous 12 months; * people who could not adhere to the protocol or were planning to have a surgical procedure in 6 months.

Keywords: dexamethasone diammonium glycyrrhizinate enteric-coated capsule
investigation of the effectiveness of regular physical activity in university students

Conditions: Regular Physical Activity; Exercise

Summary: in our study, university students who coded the course from various faculties and departments within the scope of a university-wide free elective course, after regular physical activity; it was aimed to examine the effects on lifelong learning, physical activity, fatigue, sleepiness, depression, anxiety and stress levels, quality of life and walking distances and physiological expenditure indices.

physical activity; they are body movements made using skeletal muscles in daily life and resulting in energy expenditure. in addition to daily living activities such as playing games, doing housework, walking, eating, and bathing, exercise and sports are also included in this definition. physical activity is very important for a healthy life. studies have reported that continuing physical activity, especially during growth and young adulthood, has positive effects on aerobic capacity, blood pressure, body composition, glucose metabolism, skeletal health and psychological health. studies have reported that physical activity affects social and personal success in healthy adult individuals and is associated with sleep quality and depression. in this context, our work; after regular physical activity, university students who code the course from various faculties and departments within the scope of the university-wide free elective course; it was aimed to examine the effects on lifelong learning, physical activity, fatigue, sleepiness, depression, anxiety and stress levels, quality of life and walking distances and physiological expenditure indices. hypotheses of the study; * regular physical activity improves lifelong learning tendencies in university students. * regular physical activity increases the level of physical activity in university students. * regular physical activity reduces fatigue levels in university students. * regular physical activity reduces daytime sleepiness in university students. * regular physical activity improves depression, anxiety and stress levels in university students. * regular physical activity improves the quality of life in university students. * regular physical activity improves functional capacity and increases walking distance in university students. * regular physical activity reduces the physiological expenditure index in university students.

Eligibility criteria:
inclusion criteria: * students who choose the course offered within the scope of university-wide elective courses * no obstacle to aerobic exercise * no chronic disease * individuals who have no history of surgery on the lower extremity in the last 6 months exclusion criteria: - individuals who do not volunteer to participate in the study

Keywords: physical acitivity depression anxiety sleep quality health life learning quality of life functional capasity physiological expenditure
impact of oncogeriatric consultation on quality of life of patients aged 75 and more with cancer

Conditions: Cancer

Summary: among patients with cancer, 6 in 10 are over 65 years of age. in order to improve quality of life of aged cancer patients, the oncogeriatric consultation has been created. oncogeriatric consultation aim to help oncologists determine the best solutions to combine therapy and quality of life. factors influencing quality of life of cancer patients have been studied previously. however, these studies always focus on one specific cancer.

the aim of the study is to study factors associated with quality of life in patients aged 75 and more with cancer, notably the oncogeriatric consultation.

Eligibility criteria:
inclusion criteria: * male or female * aged of 75 and more * with cancer * with indication of oncogeriatric consultation according g8 * agreeing to participate in the study exclusion criteria: -less than 75 years old

Keywords: cancers aged patients oncogeriatric consultation quality of life
the efficacy and safety of daptomycin in the treatment of gram-positive bacterial infection.

Conditions: Antibiotic

Summary: this study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of gram-positive bacterial infections. and optimize the dosing regimen based on these data.

with the gradual increase in the detection rate of drug-resistant bacteria, bloodstream infections, skin and soft tissue infections, infective endocarditis and other infectious diseases caused by mrsa, mrcns, and vre have greatly increased patient mortality and medical burden. daptomycin has strong anti-bacterial activity and rapid sterilization. it is almost 100% sensitive to common gram-positive bacteria. both domestic and foreign guidelines recommend its use for the treatment of infectious diseases such as bacteremia, central venous catheter-related bloodstream infections, infective endocarditis, skin and soft tissue infections, bone and joint infections，and so on. however, there is a lack of actual clinical use of daptomycin in china, as well as efficacy and safety assessments based on real world data. the purpose of this study is to collect and analyze data on the use of daptomycin in the real world. the clinical cure rate and inefficiency, temperature drop time, 28-day mortality rate are the primary outcome measures, and the overall incidence of adverse events, the results of cpk monitoring and its correlation with dose, renal function, length of hospital stay, and treatment costs are secondary outcome measures to investigate the efficacy and safety of daptomycin in the treatment of gram-positive bacterial infection.

Eligibility criteria:
inclusion criteria: * 1 years of age or older * meet one of the following conditions: 1. confirmed gram-positive cocci (gpc) infection; 2. cases evaluated by doctors as suspected gram-positive coccal infection with potentially high benefit from drug use； 3. severe infection patients to be combined with empirical treatment of daptomycin. * the off-label drug use conforms to the relevant administrative regulations of each participating unit. exclusion criteria: * allergic to datoramycin; * pregnant and lactating women； * patients with age \< 1 year； * participate in other clinical trials； * patients with nervous system gpc infection; * patients with pulmonary gpc infection.
efficacy of extracorporeal shock wave therapy on carpal tunnel syndrome post mastectomy lymphedema

Conditions: Carpal Tunnel Syndrome

Summary: sixty eight female patients who had symptoms of carpal tunnel syndromesuch as wrist pain or numbness and paraesthesia and had lymphedema of an upper extremity.their ages will be ranged from 40 to 60 years. the participants will be selected from out patient clinic of faculty of physical therapy, cairo university and randomly distributed into two equal groups.duration of treatment for 4weeks.all subjects signed an informed consent form, and the rights of subjects were protected.

in this study the patients will be randomly assigned into two equal groups(34 patients for each group)group a (experimental group):this group includes 34female patients who will receive extra corporeal shock wave therapy one session per week for 4 weeks in addition to physical therapy exercises (including carpal bone mobilization, nerve glide skin care and manual lymph drainage 2 sessions per week for 4 weeks. group b (control group): this group includes 34female patients who will receive shame extra corporeal shock wave therapy one session per week for 4 weeks in addition to physical therapy exercises (including carpal bone mobilization, nerve glide exercises, skin care and manual lymph drainage 2 sessions per week for 4 weeks.

Eligibility criteria:
inclusion criteria: all participants could be considered and enrolled if they conformed to the diagnosis of cts, with clinical symptoms for at least 3 months. the clinical symptoms and signs for the diagnosis of cts were as follows: 1. paresthesias and painful swelling with weakness of the affected hand, exacerbated while sleeping or by repetitive use of the wrist, which would be relieved by shaking the hand with postural change. 2. sensory loss with numbness in the regions of the hand innervated by the median nerve; 3. impaired motor function with atrophy of the median nerve-innervated thenar muscles. 4. positive tinel's sign. the subject selection will be according to the following criteria: * female patient their age range between 40-60 years. * symptoms of cts as pain, tingling sensation for at least 3 months. * unilateral or bilateral lymphedema following mastectomy * all patients enrolled to the study will have their informed consent. exclusion criteria: * the potential participants will be excluded if they meet one of the following criteria: * local infections at the hand level. * patients with prior medical histories of cardiac arrhythmias. * patient with venous thrombosis. * areas of skin with lesions and impaired sensation * other diseases that cause significant swelling. * during pregnancy and breastfeeding.