Kornimate/medical-research-clean huggingface dataset:
multisystem and autonomic complications of nmd on long-term niv

Conditions: Neuromuscular Diseases; Neurologic Disorder

Summary: this exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (nmd) who use non-invasive ventilation (niv) as part of their long-term care. autonomic function will be correlated with measures of symptom burden, disease severity and complications.

childhood-onset neuromuscular and neurological disorders (nmd) are a diverse group of rare conditions in which muscle function is significantly impaired. due to progress in nmd management over recent decades, particularly the use of non-invasive ventilation (niv) to treat chronic respiratory failure, many individuals are surviving into adulthood and even middle age. however, older individuals are developing potentially fatal complications related to the heart e.g. sudden cardiac death, gastrointestinal (gi) tract and increasing dependence on niv. previous studies largely in children and adolescents suggest individuals with nmd may develop problems of the autonomic nervous system (ans), a network of nerves vital to controlling the body's short-term responses to internal and external stimuli. it is likely some complications of nmd are related to ans abnormalities. this will be an exploratory observational study using a cross-sectional design in which non-invasive tools will be used to evaluate autonomic function during wake and sleep. individuals over 16 years of age with a confirmed nmd diagnosis will be recruited. derived parameters of autonomic function including heart rate variability will be compared to values from an exploratory reference group of age- and sex-matched healthy adults. autonomic function will also be correlated to measures of symptom burden, complications, quality of life and disease severity. qualitative methods will be used to further evaluate the experience and perceptions of adults with nmd in making decisions about their personal and medical care, which become more complex with increasing age and disease severity.

Eligibility criteria:
inclusion criteria: patient group: * age ≥16 years * confirmed diagnosis of childhood-onset nmd * able and willing to provide informed consent * requires non-invasive ventilation on an intermittent or continuous basis to manage respiratory failure reference group: * age ≥16 years * no significant co-morbidities * not on any regular medications * able and willing to provide informed consent exclusion criteria: * inability to travel to hospital site * clinical instability or acute deterioration requiring hospitalisation or changes to medication in the previous 4 weeks * a female of child-bearing potential who is pregnant or intends to become pregnant during study involvement
low dose cyclosporin a in primary sjögren syndrome

Conditions: Sjögren´s Syndrome

Summary: sandimmun optoral (cyclosporin a) is used for the musculoskeletal manifestations of primary sjögren syndrome

nsar are used currently for the treatment of musculoskeletal manifestations at sjögren syndrome for the symptomatic release of pain. for therapy-resistant cases drugs also used in rheumatoid arthritis are used. for these drugs there is no registration for the treatment of sjögren syndrome.

Eligibility criteria:
inclusion criteria: * diagnosis of a primary sjögren´s syndrome * liver values above 1,5 uln * uncontrolled arterial hypertension * intraarticular or systemic use of glucocorticoids in the last 4 weeks before * begin with study medication exclusion criteria: * pre-treatment with cyclosporine a * infection * neoplasia * relevant cardiac, pulmonary, neurologic or psychiatric disease * life-vaccination within 4 weeks before begin with study medication * pregnant or breast-feeding * weight under 45kg or more than 110kg

Keywords: primary sjogren´s syndrome cyclosporine
pars plana vitrectomy alone in the treatment of macular schisis in high myopic eyes

Conditions: Retinal Disease; Macular Retinoschisis

Summary: high myopic schisis (hmf) has the clinical feature of separation between retinal layers. it is sometimes accompanied with foveal retinal detachment, macular lamellar hole, epiretinal membrane and vitreous retraction. hmf may develop to macular hole, macular detachment and will damage the visual function. pars plana vitrectomy (ppv) is a commonly used surgery in the treatment of hmf. ppv together with internal limiting membrane (ilm) peeling and long-term gas tamponade was reported to be safe and effective. but nowadays there was no available long-term gas in our country. also, whether ilm peeling is necessary remains controversial, indole cyanine green (icg)was proved to have potential toxicity to the retina and the ilm peeling has the risk of causing secondary macular hole. we propose to make a prospective nonrandomized controlled study to evaluate the safety and efficiency of using ppv alone in the treatment of hmf.


Eligibility criteria:
inclusion criteria: 1. patients diagnosed as high myopic macular retinoschisis, with axial length more than 26.5mm. 2. morphologic manifestation in oct shows split between retinal layers in macular area. 3. patients without severe systemic disease and can tolerate surgery. exclusion criteria: 1. patients also have other ocular disease, including glaucoma, keratitis,uveitis, retinal detachment,etc. 2. patients with nystagmus or have difficult to open the eye. 3. patients with severe systemic disease and cannot tolerate surgery.
a study on the gastrointestinal disease and helicobacter pylori controlled long non-coding rna

Conditions: Helicobacter Pylori Infection; Gastric Ulcer; Duodenal Ulcer; Stomach Cancer

Summary: helicobacter pylori (h.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. however the regulatory mechanism of h.pylori-induced immune response is not clear. long non-coding rna (lncrna) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. the investigators had a preliminary results which thril (tnfα and hnrnpl related immunoregulatory lincrna) and pacer(p50-associated cox-2 extragenic rna) played a potential role in h.pylori induced inflammatory cascade. however, there wasn't a previous study about expression of thril, pacer in a human tissue. therefore, the investigators aimed to evaluate the expression of thril, pacer in patients with gastrointestinal disease according to h.pylori infection.


Eligibility criteria:
inclusion criteria: 1. over 19 years old 2. patients with gastric ulcer 3. patients with duodenal ulcer 4. patients with stomach cancer 5. patients with gastrointestinal discomfort symptoms exclusion criteria: 1. patients who has done helicobacter pylori eradication 2. patients who has undergone gastrectomy 3. patients who has undergone endoscopic submucosal dissection 4. patients with active upper gastrointestinal bleeding

Keywords: helicobacter pylori long non-coding rna thril pacer caga
metabolomic profile of patients undergoing myocardial perfusion spect

Conditions: Ischemic Heart Disease

Summary: the aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. blood samples of patients undergoing myocardial perfusion spect (single photon emission computed tomography) are taken before, immediately after stress and 2h after stress. serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

the aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. blood samples of patients undergoing myocardial perfusion spect are taken before, immediately after stress and 2h after stress. serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.

Eligibility criteria:
inclusion criteria: * patients men or women ≥ 18 years of age * patients with prescription of cardiac perfusion spect exclusion criteria: * patients with loss of consciousness or confuse, not able to read the information and to sign the writting consent * pregnant women * patients with dobutamine indications in the stress protocol

Keywords: coronary artery disease cardiac perfusion spect metabolomics
post splenectomy care assessment and the role of patient education in its improvement

Conditions: Splenectomized Patients

Summary: the goal of this trial is to evaluate compliance to booster vaccines and chemoprophylaxis in children who underwent a splenectomy and to assess the knowledge regarding this aspect before and after giving education.

the term "overwhelming post-splenectomy infection" (opsi) refers to a rapid fatal syndrome occurring in individuals following removal of the spleen. opsi can progress from a mild flu-like illness to fulminant sepsis in a short time period and has high mortality rate despite maximal treatment. the mainstays of infectious diseases prevention in asplenic subjects include: 1) patient and family education, 2) vaccinations, 3) prophylactic antimicrobial therapy in selected people, 4) early empirical antimicrobial therapy for febrile episodes, 5) early management of animal bites. studies demonstrated that patients were neither compliant to postsplenectomy booster vaccines nor chemoprophylaxis with oral penicillin. inadequate information and lack of sufficient education seem to be the major culprit behind this lack of awareness. the study will be carried out at the pediatric hematology clinic, cairo university children hospital. candidates will be given questionnaires that will inquire about education level, disease type, age, duration of illness, age at splenectomy, duration of splenectomy , reception of preoperative vaccines (pneumococcal, hemophilus, meningococcal vaccines) , compliance to postsplenectomy booster doses and penicillin prophylaxis , and if not what are the reasons for that. patients will also be given written information educating them about opsi, its red flags and the importance of post splenectomy care. interview questionnaire will be given to patients before and after education.

Eligibility criteria:
inclusion criteria: * patients above 15 years who had undergone splenectomy * caregivers of patients aged below 15 years who had undergone splenectomy exclusion criteria: * illiterate candidates * candidates who refuse to take part in the study

Keywords: overwhelming post splenectomy infections splenectomy chemoprophylaxis vaccination encapsulated organisms
postmarketing surveillance study of atrovent® inhalets in chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: to obtain further information on the tolerability and efficacy of atrovent® inhalets in the treatment of chronic obstructive pulmonary disease under conditions of daily practice


Eligibility criteria:
inclusion criteria: * patients of both gender, older than 40 years, who suffer from chronic obstructive pulmonary disease * only patients who had not been treated with atrovent® within the last year were to be considered for inclusion exclusion criteria: • contraindications listed in the instructions for use/summary of product characteristics for atrovent® inhalets
phase iia study to investigate the efficacy and safety of spp635 in diabetic and hypertensive patients with albuminuria

Conditions: Hypertension; Type II Diabetes Mellitus

Summary: this is a phase ii a, double-blind, randomized, parallel-design, four-week study to investigate the efficacy, safety and tolerability of two different doses of spp635 in type ii diabetic patients with mild to moderate hypertension and albuminuria. the total study duration for patients completing the entire study will be approximately 7 weeks including a 2 weeks screening phase, 1 week wash-out phase, 4 week treatment phase and 1 week follow-up phase. all treatments other than certain antihypertensive drugs (which are to be washed-out) with an effect on bp and all antidiabetic treatments must be kept at stable dose during the whole study. a maximum of 50 patients in total is planned to be enrolled.


Eligibility criteria:
inclusion criteria: * men or women, 18 to 75 years * hypertension * diabetes mellitus type ii * albuminuria exclusion criteria: * donation of blood in the past month * significant illness * history of malignancy * heart failure, stroke, myocardial infarction, transient ischaemic attack, or hypertensive encephalopathy within the past 6 months * current or past history of clinically significant electrocardiogram (ecg) abnormalities such as permanent 2nd degree atrioventricular (av) block or higher, unstable angina, percutaneous transluminal coronary angioplasty (ptca), coronary artery bypass graft (cabg) or cerebrovascular accident in the last three months
assessing 11c-choline (11c-ch) pet to distinguish true tumor progression from pseudoprogression in high-grade gliomas

Conditions: Brain Cancer

Summary: this is a pilot study. the purpose of this study is to test if an imaging tracer, not approved by the fda, called 11c-choline (11c-ch) is useful for evaluating your type of cancer. this tracer is used to perform pet scans. the researchers want to see if the 11c-ch pet scan, using the study tracer 11c-ch, can improve upon the usual scans at diagnosing or monitoring your type of cancer. in patients with high-grade gliomas, changes on standard mri of the brain may reflect true tumor growth or inflammatory changes in response to treatment, called pseudo-progression. it is important to distinguish true tumor growth from inflammation since inflammation indicates the tumor is responding to treatment. with standard mri, it is difficult to determine if changes following treatment are due to tumor growth or inflammation early on. researchers hope to learn if the investigational tracer, 11c-ch, will be able to distinguish true tumor growth from inflammation more accurately than standard mri or 18f-fdg pet scans.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patient is able to provide written informed consent prior to study registration * histologically-confirmed high-grade glioma * completion of treatment with standard radiation (with or without concurrent therapy). * standard gadolinium-enhanced mri changes that are considered indeterminate for tumor progression vs. treatment-related changes by the neuroradiologist or clinician within 24 weeks of completion of radiation. exclusion criteria: * inability to undergo or cooperate with an mri or pet scan (e.g., claustrophobia, metal implant) * renal insufficiency with recent (\ 2.0 mg/dl * pregnant or nursing female

Keywords: 11c-choline (11c-ch) pet 16-676 high-grade gliomas
casodex - nolvadex combination

Conditions: Gynaecomastia; Prostate Cancer

Summary: this study looks at the relationship in the dose of nolvadex and the incidence of gynaecomastia and also prostate specific antigen (psa) inhibition when co-administered with casodex. the aim of the study is to assess the optimal dose of nolvadex which will reduce the breast tissue adverse effects without reducing the efficacy of casodex.


Eligibility criteria:
inclusion criteria: * subjects with adenocarcinoma of the prostate gland but with no evidence of distant metastasis. the stage of disease should be t1-t4, any n, m0 confirmed histologically or cytologically * subjects in need of immediate hormonal therapy. * psa equal or above 4 ng/ml exclusion criteria: * presence of gynaecomastia and/or breast pain at screening visit * any previous endocrine therapy for prostate cancer other than neoadjuvant lhrh therapy prior to primary therapy of curative intent. * current use, or within the previous 6 months, of any medication known to have a high risk of causing gynaecomastia . * previous mastectomy or radiation to chest wall

Keywords: casodex bicalutamide tamoxifen gynaecomastia prostate cancer
physiopathologic study of induced by thoracotomy / thoracoscopy neuropathy mechanism

Conditions: Thoracotomy; Thoracoscopy

Summary: pulmonary surgery, performed routinely by thoracotomy or thoracoscopy, can cause significant and frequent chronic postoperative pain, most often neuropathic. the role of trauma intraoperative intercostal nerve is evoked to explain the genesis of the neuropathy. treatments proposed in the indication of neuropathic pain in a broad sense, are exposed to many cases of failures. it is supposed that these failures are due to a mismatch between the selected drug (which is specific to the target) and the real pathology because neuropathy encompasses many different pathophysiological syndromes which are sometimes intricated. the main objective of this project is to study the clinical, psychophysical and electrophysiological (noninvasively) intercostal nerve affected by the surgery at the second postoperative month, by comparing the results with similar observations made shortly before the intervention. this study will be proposed to patients undergoing thoracotomy or thoracoscopy for partial or total lung resection in the service of thoracic surgery of centre jean perrin, the objective is to recruit 120 patients (for 100 evaluable patients) over a period of 18 months of inclusion. the other objective of the project is to provide a treatment algorithm for patients in pain, and to compare the efficacy of this treatment with the pre-treatment observations data.

exploratory study, including additional examinations and visits. biomedical research.

Eligibility criteria:
inclusion criteria : * patients undergoing lateral or posterolateral thoracotomy scheduled lung surgery, regardless of indication, or lung or pleural scheduled surgery (treatment of recurrent pneumothorax) by thoracoscopy; * 18 to 80 years * informed consent to the trial * protected by the french health welfare exclusion criteria: * refusal of the patient; * preexisting neuropathy ; * treatment of active substance known on neuropathic pain: gabapentin, pregabalin, amitryptyline, duloxetine, venlafaxine, tricyclic antidepressants, topical lidocaine or capsaicin; * emergency surgery; * specific clinical contexts including terminal or palliative neoplasia; * deficit psychiatric pathology and dementia.

Keywords: thoracotomy thoracoscopy neuropathy neuropathic pain pulmonary surgery
pulmonary effects of 100% biodiesel exhaust

Conditions: Inflammation

Summary: air pollution is a global environmental and health concern, contributing to onset and deterioration of respiratory and cardiovascular diseases. as climate change and dependence on diminishing fossil fuel supplies have taken center stage in political and scientific debates, renewable carbon-neutral fuels like biodiesel receive increasing attention. the most common biodiesel within the european union, rapeseed oil methyl ester (rme) is perceived to be a "green fuel", as it is sustainable and of biological origin, and therefore is often predicted to be less harmful to human health. whilst replacing petrodiesel with biodiesel may have advantageous ecological impacts, consequences to respiratory health remained largely unexplored. the purpose of the current study is to evaluate whether inhalation of 100% rme biodiesel exhaust would result in an acute airway inflammatory response in healthy human subjects, as shown previously following exposure to petrodiesel exhaust.


Eligibility criteria:
inclusion criteria: normal ecg normal lung function normal blood samples exclusion criteria: smoking pre-existing metabolomic, respiratory and cardiovascular disease exposure to high levels of pollutants in occupation

Keywords: air pollution biodiesel exhaust bronchoscopy metabolomics
effects of nutritional supplementation in malnourished patients in stable copd

Conditions: Chronic Obstructive Pulmonary Disease(COPD); Malnutrition

Summary: insufficient energy intake and systematic inflammation lead to malnutrition in patients with chronic obstructive pulmonary disease (copd). nutritional supplementation improves the patients'nutritional status by increasing energy intake and providing anti-inflammatory elements，which can relieve the patients' symptoms and delay the disease progression.

malnutrition is very common in patients with copd. the main reasons include short intake of energy and systematic inflammation. in our randomized and controlled clinical trial, patients will be divided into two groups: the experimental group and the control group. patients in the experimental group will be provided nutritional supplements in addition to usual diet every day for three months and patients in the controlled group with usual diet. according to the changes of patients' body composition, anthropometrics, inflammatory markers, lung function, respiratory muscle function, exercise capacity, degree of dyspnea and health related quality of life(hrql) after intervention，the nutritional status and inflammation status are assessed, which contributes to the prediction of prognosis. the nutritional supplements is a kind of oral liquid composed of proteins, omega-3 fatty acids, carbohydrate, vitamins, which provides about 260 kcal energy per 200ml. the patients from the interventional group need drink the nutritional supplements according to the estimated energy intake and a record should be made everyday. the patients will be followed up regularly by the researcher.

Eligibility criteria:
inclusion criteria: patients from zhujiang hospital affiliated from southern medical university patients aged between 40 and 90 years old patients gendered into male or female patients with pulmonary function test of fev1/fvc\<70% and fev1\<80% predicted patients presenting one or more of the following situations of malnutrition or nutritional risk: bmi \ 10% in the past 6 months; unintentional weight loss \>5% in last month; ffmi \<15 kg/m2 (women) or \<16 kg/m2 (men) patients able to answer question patient able to eat and drink patients who signed informed consent exclusion criteria: patients with signs of an airway infection patients with malignant disorders patients with recent surgery patients with gastrointestinal ,cardiovascular diseases,neurological diseases or endocrine disease patients with bullae lung patients treated with oral steroids or immunosuppressors patients requiring other nutritional supplements or parenteral nutrition patients suffering from acute exacerbation over the previous 4 weeks patients with lack of motivation or poor compliance

Keywords: copd malnutrition nutrition supplementation