Kornimate/medical-research-clean huggingface dataset:
acupuncture for the treatment of vision loss due to retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: retinitis pigmentosa (rp) patients are interested in trying alternative therapies to attempt to slow, halt or reverse the retinal disease process, and claim success with some approaches such as acupuncture, but this potential treatment has not been put to the test of objective, rigorous scientific study conducted in western society. in this pilot study, the investigators aim to evaluate an acupuncture treatment tailored to the rp population for its feasibility to improve visual function, specifically visual field and dark adaptation. the study results may provide a basis for eye care providers' recommendations to rp patients regarding whether to consider acupuncture as a potential treatment modality. if our hypotheses regarding improvements in vision beyond typical test variability are supported, our future research goals include the conduct of a larger clinical trial with involving randomization and a placebo control for acupuncture in rp.


Eligibility criteria:
inclusion criteria: * age 10+ * diagnosis of retinitis pigmentosa * best-corrected visual acuity better than 20/400 in at least one eye * more than 20% loss of goldmann visual field area (iii4e) in at least one eye * able and willing to participate in all study visits in baltimore for the 8-week program * provide informed consent exclusion criteria: * very severe vision losses in both eyes (e.g., hand motions or light perception only) with difficulty performing the proposed vision tests * vision loss due to ocular diseases other than rp, cystoid macular edema, or cataracts * schedules do not permit participation in all study visits * previous acupuncture treatment in the last 6 months * inability to understand study procedures or communicate responses to visual stimuli in a consistent manner (cognitive impairment) * dementia; long or short-term memory loss * unable to read or speak english * smoking, substance abuse, or illegal drug use * receiving current psychiatric care (i.e. unstable emotional and mental health status) * history of excessive bleeding

Keywords: retinitis pigmentosa
clinical utility of selected circulating tumor dna assays in patients with advanced malignancy

Conditions: Metastatic Colorectal Cancer; Pancreas Adenocarcinoma; Cholangiocarcinoma

Summary: circulating tumor dna assays are becoming relevant for routine diagnostics, but many related aspects are yet unresolved. with this project, the investigators aim to develop pragmatic molecular diagnostic pathways of liquid biopsies relevant in advanced gastrointestinal malignancies with focus on clinical utility and sensible use of resources. they want to evaluate the ctdna assays on a fully automated "low-cost" multiplex platform which is already implemented in routine molecular diagnostics of solid biopsies. the project will evaluate to what extent these ctdna assays are relevant for clinical decision-making.

advanced pancreatic cancer (pdac) and cholangiocarcinoma (cca): -could the idylla ctkras test select the \~10% of pdac patients with kraswt eligible for more extensive diagnostics? in pdac and cca, is it possible to detect patient samples with kras g12c or braf mutation for study inclusion? could the δcq-value of the tests be used as a semi-quantitative tumor marker? what is the clinical value compared to the current tumor marker ca19-9? • metastatic colorectal cancer: are the ctdna assays useful in detecting primary resistance and/or monitoring for secondary/acquired resistance to egfr antibody treatment? how does the sensitivity, specificity and turnaround time of the ctdna assays compare to tissue-based analysis? could the idylla ctdna assays accelerate detection of kras g12c or braf mutations, and hence facilitate study inclusion in the first line setting? could the ctdna assays guide rechallenge with egfr treatment? can the information of liver metastases or prognostic markers (s-cea, s-crp) guide timing of ctdna sampling?

Eligibility criteria:
inclusion criteria: newly referred patients with advanced pancreatic cancer (\~20/year), cholangiocarcinoma (\~20/year), metastatic colorectal cancer (mcrc) (\~50/year) and anti-egfr-treated mcrc patients (\~10/year) to oslo university hospital are eligible for inclusion.

Keywords: circulating tumor dna
a clinical evaluation of an investigational lubricant eye gel (fid 115958d)

Conditions: Dry Eye

Summary: the purpose of this study is to estimate the change in sodium fluorescein staining, as a sign of dry eye, during six weeks of treatment with fid 115958d or refresh liquigel.


Eligibility criteria:
inclusion criteria: * documented diagnosis of dry eye * nafl corneal staining sum score ≥ 3 in either eye * current use of a lubricant eye gel or ointment at least once per week (over the previous month) exclusion criteria: * no contact lenses wear throughout the study period * must not have had punctal plugs inserted within 30 days preceding enrollment

Keywords: dry eye artificial tears corneal staining
liver diseases in plwh

Conditions: HIV/AIDS; Liver Diseases

Summary: in highly active antiretroviral therapy era, fatty liver has become an important cause of liver function damage in people living with hiv (plwh). there are a large number of plwh in china who are infected with hepatitis b virus and hepatitis c virus. hiv, hepatitis b virus, hepatitis c virus, drugs, alcohol, etc. affect each other, which makes the cause, diagnosis, and treatment of liver function damage in plwh complicated in china. the investigators plan to conduct a large-scale questionnaire survey among plwh in zhejiang province to assess liver function, detect liver injuries early, and analyze hiv, hepatitis b virus, hepatitis c virus, anti-hiv drugs, alcohol and other factors associate with liver injuries in plwh, to provide basis for the treatment and prevention of liver disease in plwh in eastern china.


Eligibility criteria:
inclusion criteria: * age ≥18 years old; * non-hospitalized patients diagnosed with hiv infection; * sign the informed consent voluntarily. exclusion criteria: * severe active infection requiring parenteral antibiotics or antifungal treatment within 30 days before the assessment; * other major chronic diseases that may affect health-related quality of life, such as extrahepatic malignant tumors; * psychotic patients, patients with severe cognitive or neurological deficits; * women during pregnancy and lactation; * those who refuse to sign informed consent.
flacs in pediatric patients using femto ldv-z8

Conditions: Cataract in Child

Summary: this study is a single center prospective observational case series. the framework of this clinical investigation is post market clinical follow up of pediatric flacs using the femto ldv z8. the intention is to investigate and supervise aspects particular to the pediatric use, and there is hence no alternative patient population. primary outcome related adverse events at the time of surgery, ophthalmic adverse events at 1 week, 1 month, 6 months. secondary outcome achieved vs aimed capsulotomy diameter * aimed diameter to be calculated using the bochum formula * achieved diameter will be assessed using a ring caliper (morcher 4.8 external diameter), (us patent mj tassignon) during the recruitment period, the legal representatives of all patients (and when applicable the patients) at the study site who are eligible for pediatric cataract surgery and fulfilling the eligibility criteria will be informed about the study and offered participation. the aim is to include 12 participants during the recruitment period of 6 months. inclusion criteria are on purpose chosen very broad, in order to collect data from all types of pediatric cataract surgeries.the majority of the participants will be very young children, who cannot be involved in the informed consent procedure. participants will nevertheless receive the patient information in a way adapted to their age and mental maturity, from investigators or members of the investigating team who are experienced in working with children. the study procedure is cataract surgery performed with the femto ldv z8 femtosecond laser. in this clinical investigation the ce marked products (the femto ldv™ femtosecond laser and the femto ldv™ surgical laser procedure packs for cataract surgery) are used without deviations from the intended use and indication for use. intraoperatively the achieved capsulotomy diameter will assessed using a ring caliper (morcher 4.8 external diameter) and compared with the aimed diameter calculated using the bochum formula. patients will return for follow-up visits at 1 week, 1 month, 6 months after the surgery.


Eligibility criteria:
inclusion criteria: 1. age \< 18 years at the time of surgery 2. in case of bilateral cataract, only one eye will be included in the study 3. informed consent of the legal representative of the patient (and as applicable, the patient) documented per signature 4. planned cataract surgery 5. accurate baseline biometric measurements 6. assessed medical status 7. full pupil dilatation is achieved using cyclopentolate eye drops exclusion criteria: 1. eyes with microphthalmia of \< 9 mm diameter white to white 2. hazy cornea 3. pregnancy; girls of childbearing age will be tested for pregnancy with urinary analysis (hcg) at the time of inclusion.

Keywords: flacs femto-ldv z8 pediatric cataract
the effect of smoking on thermoregulation

Conditions: Cigarette Smoking

Summary: to the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a thermogenic effect, decreases physical fitness and affects the body's heat dissipation.16 healthy young male volunteers will participate in the study, 8 smokers and 8 non-smokers. they will arrive to our lab four or six times. they will perform vo2 test and heat tolerance test (htt) in different conditions.

16 healthy young male volunteers will participate in the study, 8 smokers and 8 non-smokers. they will arrive to our lab four or five times. during their first visit they will go through a vo2 max test in order to evaluate their aerobic fitness, and their physiological efficiency. during their second visit all subjects will go through the same test after exposure to nicotine. during the smokers' third visit they will go through the same test, after exposure to cigarette smoking. during the non-smokers third visit and the smokers fourth visit - they will go through an exercise heat tolerance test without prior smoking. during the fifth visit the smokers will go through an exercise heat tolerance test after exposure to cigarette smoking. during the smokers' sixth visit and the non-smokers fourth visit they will go through an htt after exposure to nicotine.

Eligibility criteria:
inclusion criteria: * age 18-30 * healthy * after medical checkup * after signing concent form * for the smokers: smoking 0.5-1.5 packs of cigarettes a day at least 2 years. exclusion criteria: * heart disease * respiratory disease * baseline bp above 140/90 mmhg * diabetes * anhydrosis * skin disease * acute illness * detoxification from nicotine * allergy to nicotine * smoking other then specified in the inclusion criteria

Keywords: smoking exercise heat tolerance heat stroke
oxycodone in combination with parathoracic nerve block is used for postoperative analgesia in lung cancer

Conditions: Oxycodone

Summary: in this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone were explored, which provided a reference for the clinical multimodal analgesia after thoracoscopic lung cancer surgery.


Eligibility criteria:
inclusion criteria: 1. male or female, age \> 60 years 2. patients undergoing thoracoscopic lobectomy 3. asa (american academy of anesthesiologists) grades i-iii 4. there were no obvious abnormalities in heart, liver, and kidney function 5. sign the informed consent form for this clinical study exclusion criteria: 1. history of oxycodone or sufentanil allergy 2. renal or hepatic dysfunction 3. history of drug or alcohol abuse 4. psychiatric disorders: schizophrenia, epilepsy, parkinson's disease, myasthenia gravis 5. those who have difficulty communicating due to coma, severe dementia, speech barrier, or those who cannot cooperate due to other diseases. 6. people with head trauma or other brain diseases -

Keywords: oxycodone postoperative analgesia lung cancer thoracic paravertebral nerve block
pneumothorax post ct lung biopsy

Conditions: Lung Nodules

Summary: a ct scan is performed after a lung biopsy in order to detect a pneumothorax. we postulate that ct is more useful than chest radiography


Eligibility criteria:
inclusion criteria: * all patients having a lung biopsy exclusion criteria: * none
observatory on elderly patients "les s.ages"

Conditions: Diabetes Mellitus, Type 2; Chronic Pain; Atrial Fibrillation

Summary: primary objective shared by the 3 registries : describe the different pharmacotherapeutic management in patients : * db (diabetes): with type 2 diabetes, treated with oral and / or injectable antidiabetics * cp (chronic pain): with any disease leading to chronic pain (lasting for more than 3 months) * af (atrial fibrillation): with ongoing af or af diagnosed within 12 months before enrollment secondary objectives shared by the 3 observatories: * describe the occurrence of clinical events, hospitalizations and death, according to the different medical care conditions, and analyze their predicting factors * estimate the resources consumption according to the medical and non medical management of these patients, * analyze the impact of some factors (patient's cognitive status, autonomy, renal function ...) on the current practice secondary objectives specific shared by db and af registries : - analyze the geriatric pharmaco-genetic aspects specific secondary objectives for each observatory : * db : describe hba1c level, percentage of responders and body weight evolution according to the different medical care conditions * cp : evaluate pain consequences on daily living activities and patient autonomy


Eligibility criteria:
inclusion criteria specific for each observatory : * db : established type 2 diabetes treated with oral and / or injectable antidiabetics * cp : pain lasting for over 3 months, requiring therapeutic care * fa : ongoing atrial fibrillation or af diagnosed within the 12 months before enrollment and documented by ecg or holter ecg, whatever the rhythm at inclusion exclusion criteria shared by the 3 observatories: * living in accommodation facility for dependent patients * patient with non cardiovascular progressively unstable disease * patient already enrolled in a clinical trial * patient unlikely to complete the study exclusion criteria specific for just af observatory : - transitional af due to thyrotoxicosis, alcohol, myocarditis, pericarditis, acute myocardial infarction, pulmonary embolism, metabolic disorders or electrocution, post cardiac surgery af (\<3 months). the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
evaluation of a probiotic supplementation in the immune response of participants with covid-19 (coronavirus disease).

Conditions: Covid19

Summary: an interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a probiotic strain on the immune response in participants positive for sars-cov-2 infection. the study duration will be 28 days, which includes 4 weeks product administration. participants will be randomized assigned to one of the two study groups: the control group with placebo consumption and a probiotic consumption group.


Eligibility criteria:
inclusion criteria: * adult (18-65 years). * mild infection by sars-cov-2 detected by pcr or antigen. * onset of covid-19 symptoms up to 5 days before the day of inclusion * without hospitalization or oxygen supplementation on the day of inclusion. * signed written informed consent exclusion criteria: * serious sars-cov-2 infection requiring hospitalization or oxygen supply * chronic diseases under regular medication (eg asthma, allergic rhinitis ...) * congenital or acquired immunodeficiency * body mass index (bmi)\> 30 * coagulation disorders * short bowel syndrome or any surgery on the gastrointestinal tract. * metabolic disorders (diabetes, etc.). * heart failure and cardiac medical history * pregnant women. * hiv positive. * immunocompromised * history of significant gastrointestinal diseases * use of other probiotics during the last month. * uncertainty about the willingness or ability of the participant to comply with the requirements of the protocol.
telemedicine for sleep apnea patients

Conditions: Sleep Apnea

Summary: objective: set up an interoperable telemedicine system for the follow-up of patients with sleep apnea syndrome.

the medico-economics protocol will use the mast (methodology for assessment of telemedicine) criteria. 200 patients will be randomized into 2 arms (telemedicine with gprs transmission of cpap data from patients' home and classical follow-up) during the 3 first months of the follow-up. the main end-point is cpap compliance with the aim of detecting a mean increase of at least 1hr in the use of cpap.

Eligibility criteria:
inclusion criteria: * ahi \> 30/hr * hypersomnolence * agreement for the use of cpap * internet and gsm connection exclusion criteria: * central apnea \>20%, * pneumothorax, * severe nasal obstruction, * previous pharyngeal surgery, * severe copd, * heart failure, * previous use of cpap, * no social security coverage, * unavailability, * no gsm and internet network

Keywords: cpap adherence saos telemedicine
chatbot-based internet intervention for stress among university students (stressbot)

Conditions: Stress, Psychological

Summary: the aim of this study is to verify the efficacy of chatbot internet intervention for reduction of stress and improvement of quality of life among university students through the enhancement of coping self-efficacy.

university students experience high stress levels and mental health risks. research shows that increasing resources such as coping self-efficacy can reduce stress. internet interventions can be successfully employed to deliver programs for improving university students' mental health. the primary objective of this randomized controlled trial is to evaluate short- and long-term efficacy of coping self-efficacy enhancing intervention in reducing university students' stress and improving quality of life. the intervention will be delivered through a facebook messenger chat-bot. the secondary goal is to investigate acceptability of a chat-bot delivered intervention. participants will be recruited via social media and randomized to 1 of 2 groups: (1) experimental condition increasing coping self-efficacy with a 7-day program delivered through a chat-bot, or (2) waitlist control group. outcomes include perceived stress and quality of life. measurements will be taken at baseline (t1), immediately after intervention (t2), at 1 month follow-up (t3), and at 6 months follow-up (t4). linear mixed effects model will be used to analyze the data. the study aims to assess stressbot's potential benefit for improving university students' well-being. moreover, it will provide insight into feasibility of using chat-bots for delivering smartphone-based e-health treatments.

Eligibility criteria:
inclusion criteria: * age of at least 18 years * university students * mobile personal device with internet access exclusion criteria: * not meeting at least 1 inclusion criteria
a comparison of four different treatment regimens of helicobacter pylori in chinese children

Conditions: Helicobacter Infections

Summary: with the resistance of helicobacter pylori increasing, low and unsatisfactory eradication rate (64%) have been observed with standard triple therapy in european children. which regimen is appropriate for chinese children? there is no large scale, multi center studies in china about treatment, cyp2c19 gene polymorphism, resistance rate and resistance genotype. investigators want to perform a research to compare four different treatment regimens（triple therapy, sequential therapy, bismuth quadruple therapy and concomitant therapy）as the first-line treatment of helicobacter pylori in chinese children and investigation of resistance, impact factors and changes of microbiota after the therapy. the results of the study will provide theoretical basis to make the new guideline of diagnosis and therapy of helicobacter pylori in chinese children. it advance instruct and norm the clinical practice for chinese pediatrician to increase the cure rate of helicobacter pylori and decrease the resistance.

eligible children were randomly divided into four groups: standard triple therapy, sequential therapy, bismuth quadruple therapy and concomitant therapy. the course of treatment is 14 days. the primary outcome measure was the hp eradication rate at 4-6 weeks after completion of treatment which was confirmed by a negative of 13 ubt. secondary outcome measures included side effects, impact factor and changes of microbiome after the therapy.

Eligibility criteria:
inclusion criteria: * children 6-18 years of age who were referred for upper endoscopy and confirmed to have hp infection exclusion criteria: * patients were excluded if they had taken proton pump inhibitors, h2-receptor antagonists or antibiotics in the 4 weeks prior to the study. patients with known antibiotic allergy,hepatic impairment or kidney failure were also excluded. patients who received hp therapy before were also excluded.
davallia divaricata bl: the use of traditional chinese native medicine for osteoporosis

Conditions: Osteoporosis

Summary: we, the investigators at national taiwan university hospital, have determined the therapeutic and toxic effects of the traditional herb on the ovariectomized wistar rat. the final years will determine its effects on the therapy of women who are over 45 years old and postmenopausal with osteoporosis.

research of this traditional chinese clinical medicine, gusuibu, curative effect is planned for three years time. the entire study aims to evaluate the effect of the traditional chinese medicine on postmenopausal osteoporosis as well as the possible side effects on the experimental animal and the human body. all subjects were postmenopausal women with established osteoporosis.

Eligibility criteria:
inclusion criteria: * postmenopausal osteoporosis exclusion criteria: * insulin dependent diabetes