Kornimate/medical-research-clean huggingface dataset:
assessing the accuracy of seismofit® as an estimate of vo2 peak in patients with hepato-pancreato-biliary, colorectal, and gastro-oesophageal cancer

Conditions: Hepato-Biliary Carcinoma in Situ Nos; Pancreatic Cancer; Colorectal Cancer; Gastric Cancer; Oesophageal Cancer

Summary: our study aims to assess the relationship between the seismofit® derived vo2 peak estimate and cpet-measured vo2 peak in patients who are having cpet as part of their preoperative workup. our aim is to establish whether seismofit® can be considered a cheaper, less resource intensive and better tolerated alternative to the cpet, or whether it might be useful as a screening tool to efficiently identify patients with exercise intolerance who may benefit from further characterisation by cpet.


Eligibility criteria:
inclusion criteria: 1. age ≥18 2. scheduled for elective surgery for resection of hpb, colorectal or gastro-oesophageal primary or secondary cancer 3. undergoing cpet as part of routine pre-operative investigations exclusion criteria: 1. subjects unable to give voluntary written informed consent to participate in this study 2. diagnosis of moderate or worse stenosis or regurgitation of any cardiac valve 3. previous aortic or mitral valve surgery, valvuloplasty or transcatheter valve implantation 4. permanent pacemaker or cardiac resynchronisation device in situ 5. diagnosis of severe pulmonary hypertension 6. permanent atrial fibrillation
exercise-induced irisin in individuals with knee osteoarthritis.

Conditions: Knee Osteoarthritis (Knee OA)

Summary: the goal of this prospective randomised controled study is to investigate the effect of 8-weeks brisk walking exercise on irisin levels, physical and psychosocial parameters in individuals with knee osteoarthritis, and the relationship between irisin levels and physical and psychosocial parameters. the main question it aims to answer is: does 8-weeks brisk walking exercise increase irisin levels and imoroves physical and psychosocial parameters and is the irisin level in relation with the physical and psychosocial parameters.

irisin is a myokine secreted by skeletal muscle after physical activity. it improves subchondral bone density and quality by increasing osteoblast differentiation and proliferation and improves the mechanical support of cartilage. in addition, irisin promotes chondrocyte proliferation, inhibits chondrocyte apoptosis, and reduces the secretion of inflammatory factors and matrix metalloproteinases. as a result of all these, improvements in joint function may be achieved. besides, irisin can improve depressive mood in patients with depression, and irisin level is found to be positively correlated with sleep quality and negatively correlated with disease duration and disease activity in patients with rheumatoid arthritis. this study aims to investigate the effect of an 8-week moderate-intensity brisk walking exercise program on irisin serum levels and physical and psychosocial parameters in individuals with knee osteoarthritis and the relationship between irisin levels and physical and psychosocial parameters.

Eligibility criteria:
inclusion criteria: * patients with idiopathic knee oa * stage 1-3 knee oa according to the kellgren-lawrence classification * patients aged 40-65 * patients agreeing to participate in the study * patients having physical and cognitive ability to participate in the exercise program exclusion criteria: * history of depression and/or anxiety etc. psychiatric disease * uncontrolled hypertension, uncontrolled heart rhythm disorders, history of hospitalization for cardiovascular reasons in the last 6 months * history of symptomatic pulmonary disease * use of medication due to dyslipidemia and/or diabetes * presence of acute inflammation or effusion in the knee joint * presence of central or peripheral neurological disease that will cause loss of lower extremity muscle strength, sensation, and balance * presence of a prosthetic joint in the knee and previous lower extremity surgery * having received a physical therapy program in the last 6 months * patients with severe visual or hearing impairment * patients with severe peripheral vascular disorders * presence of severe knee joint instability, ligament and meniscal damage * being illiterate

Keywords: knee osteoarthritis i̇risin fndc5 pain functional capacity depression fatigue sleep quality quality of life muscle strength
mitral valve regurgitation quantification from 3d color doppler ultrasound - standard of care data collection

Conditions: Mitral Valve Regurgitation of Any Grade

Summary: the study primarily aims to collect standard of care clinical data in a wide spectrum of simple to complex mitral valve regurgitation (mvr) cases to validate a post-processing stand-alone software prototype (qflow), developed by philips research paris (medisys). investigator does not intervene in the care of the patient, but simply collects standard of care images and measurements that are needed for the validation of the investigational software.


Eligibility criteria:
inclusion criteria: * both genders * age between 18 and 85 years old (adult, senior) * sinus rhythm * hhemodynamic stable * mitral valve regurgitation (mvr) of any grade i.e., from mild to severe as determined by assessment of a qualifying transthoracic echocardiography (tte) exam at saint-luc university hospital * scheduled for transesophageal echocardiography (tee) at saint-luc university hospital, as part of the subject's routine standard of care * subjects has functional capacity to give written informed consent exclusion criteria: * pregnancy * subject lacks functional capacity to give written informed consent belongs to a vulnerable population per investigator's judgment or subject has any kind of disorder that compromises his/her ability to give written informed consent and/or to comply with study procedures among the120 subjects, there will be three (3) sub-groups as follows: * a first sub-group (a) of 50 subjects with all inclusion criteria and none of the exclusion criteria * a second sub-group (b) of 50 subjects with additional inclusion criterion: scheduled for cardiac magnetic resonance (cmr), as part of the subject's routine standard of care * a third sub-group (c) of 20 subjects with additional inclusion criterion: scheduled for mitraclip transcatheter mitral valve repair (mitraclip) procedure as part of the subject's routine standard of care
a smart home-based exoskeleton robot system for stroke patients

Conditions: Rehabilitation, Tenodesis, Stroke, Internet of Things

Summary: in the proposed study, the investigators assumed that high dose of repetitive motor task training using an exoskeleton robot-assisted system may provide benefits in motor shaping and greater brain priming for hand paresis of the stroke patients. nevertheless, the amount of therapeutic activity with clinicians' guidance is often short of number in therapy sessions.therefore, using internet of things (iot), connected rehabilitation products and the data they generate that are a new trend of rehabilitation strategy for providing remote home-programs support. the specific aim of this study is to to explore the feasibility of introducing the rental services of a smart home-based exoskeleton robot system through the iot business model. and the second purpose is to investigate the effects of applying the exoskeleton robotic device for tenodesisgrip training as a home-based treatment for chronic stroke patients.the expected outcomes of this research are to clarify the feasibility of using iot business model for launching smart rehabilitation device rental service and the effects of application a high dosage of hand movement training as home program on motor and hand function for patients with chronic stroke.


Eligibility criteria:
inclusion criteria: * (1) chronic stroke patients with unilateral cerebral infarction or hemorrhage, (2) computed tomography scan that excluded pathologies other than unilateral cerebral hemisphere injury, (3) capacity to perform a pinch task with the thumb and index finger, (4) no major cognitive or perceptual deficit (i.e., visual, auditory, perceptual, praxis, and memory, as determined using lowenstein occupational therapy cognitive assessment), (5) premorbid right-handedness and (6) first-ever stroke. exclusion criteria: * not meeting inclusion criteria, and with wernicke's aphasia or global aphasia leading to difficulty of following instruction.
early case management on recovery from a cardiac event in women

Conditions: Cardiac Rehabilitation

Summary: outpatient cardiac rehabilitation (cr) is an exercise-based lifestyle program for patients who have experienced a myocardial infarction, systolic heart failure, percutaneous revascularization or cardiac surgery. cr plays a key role in secondary prevention, which is the prevention of subsequent cardiac events. cr has been shown to reduce both cardiovascular mortality and one year hospital readmissions as well as improve quality of life, exercise capacity, and physical function. although the benefits have been clearly established for cardiac patients, women are much less likely to attend cr than men. based upon our own preliminary data (and the medical literature), attendance at cr is determined by factors that vary in their importance between men and women. these findings demonstrate that older age and poor social support are particular barriers to cr participation in women. this information can guide efforts to increase cr participation and adherence in women, areas which have received little study. case management (cm) has been effective at reducing cardiovascular risk and reducing hospitalizations amongst cardiac patients. further, cm has been effective at promoting attendance in a variety of health related programs (for example, diabetes treatment or cocaine dependence treatment). the primary aim in this randomized controlled trial is to examine the efficacy of early cm to promote participation and adherence in cr. the cm model can identify individualized determinants of health and social needs to identify potential barriers which may hinder cr enrollment. additionally, the case manager will conduct a home visit and provide individual counseling to address lifestyle changes including physical activity. thus, a component of cr and physical activity can be still be delivered for those unable to attend cr. the concept of cm to improve cr participation and adherence has not been specifically tested in women, a vulnerable patient population. this intervention, therefore, has the potential to increase utilization of cr and significantly improve health outcomes in female cardiac patients.


Eligibility criteria:
inclusion criteria: - inclusion criteria: 1. a cardiac rehabilitation qualifying condition including: a recent myocardial infarction or coronary revascularization or heart valve replacement or repair, stable angina, or congestive heart failure (ejection fraction \<35%) 2. lives in and plans to remain in the greater burlington, vermont area for the next year. exclusion criteria: 1. severe dementia 2. advanced cancer, advanced frailty, or other longevity-limiting systemic disease 3. severe life threatening ventricular arrhythmias unless adequately controlled (e.g. intracardiac defibrillator) 4. exercise-limiting non-cardiac disease such as severe arthritis, past stroke leading to paralysis 5. participation in cardiac rehab within the past year

Keywords: secondary prevention, women's cardiovascular disease, case management
efficacy and safety study of reslizumab to treat poorly controlled asthma

Conditions: Asthma

Summary: the purpose of this study is to determine the effectiveness and safety of reslizumab in the treatment of subjects with poorly controlled asthma.

objectives: primary: to demonstrate the ability of reslizumab to improve asthma control in subjects with active asthma and eosinophilic airway inflammation. secondary: * to study the ability of reslizumab to reduce induced sputum eosinophil (eos) counts in subjects with asthma. * to study the ability of reslizumab to reduce the number of eosinophilic clinical asthma exacerbations (cae) in subjects with asthma. a cae is defined as a ≥ 20% decrease in forced expiratory volume in 1 second (fev1; absolute value) from the baseline value or a requirement for emergency treatment of asthma, hospital admission for asthma or treatment with three or more days of oral corticosteroids (ocs) for asthma worsening. * to assess the safety and tolerability of reslizumab in subjects with asthma.

Eligibility criteria:
inclusion criteria: * written informed consent * male or female subjects aged ≥ 18 to 75 years at time of screening * female if she is of non-childbearing potential, or of childbearing potential and willing to use specific barrier methods specified in protocol * confirmation of asthma * symptoms consistent with a diagnosis of asthma that is poorly controlled with an inhaled corticosteroid as determined by an asthma control questionnaire (acq) score ≥ 1.5 * requirement for treatment with high dose daily fluticasone and at least one other agent for the treatment of asthma not specifically excluded in the protocol * requirement for \>/= 3% eosinophils in induced sputum at screening exclusion criteria: * a clinically important event that would interfere with study schedule or procedure or compromise subject safety * a diagnosis of hypereosinophilic syndrome * an underlying lung disorder * a current smoker * use of systemic immunosuppressive agents within 6 months of study * current use of systemic corticosteroids * received attenuated live attenuated vaccines within three months prior to study entry * expected to be poorly compliant with study drug, procedures, visits * aggravating factors that are inadequately controlled * participation in any investigational drug or device study within 30 days prior to study entry * participation in biologics study within 3 months prior to study entry * receipt of anti-human interleukin-5 (hil-5) antibody within 6 months of study entry * female subjects who are pregnant or nursing * concurrent infection or disease that may preclude assessment of eosinophilic esophagitis * concurrent immunodeficiency (human immunodeficiency \[hiv\], or acquired immunodeficiency syndrome \[aids\] or congenital immunodeficiency). * current suspected drug and/or alcohol abuse

Keywords: cinquil™ reslizumab
effect of goal-directed hemodynamic therapy on short-term postoperative complications in patients with extensive burns

Conditions: Hemodynamics

Summary: to investigate the effect of goal-directed hemodynamic management on perfusion and short-term prognosis of patients undergoing scab grafting in early stage of extensive burns.

objective: to investigate the effect of goal-directed hemodynamic management on perfusion and short-term prognosis of patients undergoing scab grafting in early stage of extensive burns. methods: ninety-five patients with extensive burns undergoing early debridement grafting were randomly divided into a standard hemodynamic management group (control group) and a goal-directed hemodynamic therapy group (gdht group), with the control group guided by conventional parameters and the gdht group guided by sv based on vigileo. the primary outcome were incidence of cardiac complications, pulmonary complications, neurological disease, acute kidney injury, and pain within 7 days postoperatively. secondary outcome included microcirculatory perfusion metrics: lactate (lac), the central venous-arterial carbon dioxide partial pressure difference (pcv-aco2).

Eligibility criteria:
inclusion criteria: 1. the age is between 18 and 65 years old; 2. the burn area ≥ 50% total burn surface area (tbsa) or the third degree wound area ≥ 20% tbsa; 3. patients will undergo the first operation after fluid resuscitation (after the shock period). the types of operation include incision decompression, escharectomy and skin grafting, and so on. exclusion criteria: 1. severe cardiac or pulmonary disease prior to the burn injury, combined with severe internal organ damage. 2. patients or family members refusing informed consent for this study.
using customized nasal conformer in correction of cleft nasal deformity in patients with unilateral cleft lip

Conditions: Unilateral Cleft Lip

Summary: the goal of the study is to compare the cleft lip repair with and without the usage of customized milled nasal conformers in unilateral cleft lip patients on nostril size , alar cartilage and proportion of symmetry to the normal side . * comparing anthropometric measurements similarity between cleft and normal sides such as; nostril width and height , columellar deviation and nasolabial angle. * evaluation of degree of similarity using esthetic scales at six months postoperative. participants will receive nasal conformers intraoperative with follow up of 6 months.


Eligibility criteria:
inclusion criteria: 1. patients of both sexes with unilateral cleft lip. 2. age range 10 - 24 weeks. 3. hemoglobin more than 10 gm/dl . 4. weight more than 10 lbs. exclusion criteria: 1. syndromic patients. 2. patients with conditions contradicting operation. 3. patients with bilateral cleft lip. 4. patients with previous surgeries in lip and nose.
comparison of papillary balloon dilatation vs.sphincterotomy for lithotripsy in difficult sphincterotomy or distal cbd tapering

Conditions: Choledocholithiasis

Summary: compare endoscopic papillary balloon dilatation vs. endoscopic sphincterotomy for bile duct stones in: * when sphincterotomy is difficult (periampullary diverticulum, prior sphincterotomy or billroth ii anastomosis) * when there is distal cbd tapering.

endoscopic papillary balloon dilatation is an alternative to endoscopic sphincterotomy for treating bile duct stones: * easier and as effective. but... * a higher risk of pancreatitis. conditions including periampullary diverticulum, prior est, billroth-ii anastomosis, or distal cbd tapering pose difficulty in est and lithotripsy with increased risk of complications. whether epbd or est is superior in efficacy or safety under such circumstances is not clear.

Eligibility criteria:
inclusion criteria: * choledocholithiasis with * difficult sphincterotomy:periampullary diverticulum, prior sphincterotomy or billroth ii anastomosis * or distal cbd tapering. exclusion criteria: * patients in whom no endoscopic papillary balloon dilatation or endoscopic sphincterotomy was performed for lithotripsy

Keywords: endoscopic papillary balloon dilatation endoscopic sphincterotomy
a chatbot to reduce physical and psychological distress of patients with head and neck cancer undergoing radiotherapy

Conditions: Head and Neck Cancer

Summary: the goal of this clinical trial is to assess the effectiveness of the digi-coach chatbot for reducing physical and psychological distress in people undergoing radiotherapy for head and neck cancer. the main question it aims to answer is: how effective is the digi-coach chatbot in reducing physical and psychological distress? researchers will compare digi-coach chatbot to usual nursing care to see if digi-coach chatbot is effective for reducing physical and psychological distress in people undergoing radiotherapy for head and neck cancer. participants will have access to the digi-coach chatbot during radiotherapy in addition to usual care. the research nurse will provide training on how to navigate the chatbot and ask participants to query all their cancer-related concerns in the chatbot.

the goal of this clinical trial is to assess the effectiveness of the digi-coach chatbot for reducing physical and psychological distress in people undergoing radiotherapy for head and neck cancer. the main question it aims to answer is: how effective is the digi-coach chatbot in reducing physical and psychological distress? researchers will compare digi-coach chatbot to usual nursing care to see if digi-coach chatbot is effective for reducing physical and psychological distress in people undergoing radiotherapy for head and neck cancer. a single-blinded parallel randomized controlled trial (rct allocation ratio = 1:1) will be conducted, with baseline data collection at week 1 (t0) and three follow-up timepoints at week 8 (t1), week 12 (t2) following radiotherapy commencement. participants in the treatment-as-usual group will receive routine onsite nursing care in which the nurse discussed general knowledge of self-care behaviors regarding the management of radiotherapy-related side effects. participants in the intervention group will have access to the digi-coach chatbot in addition to usual care. the research nurse will provide training on how to navigate the chatbot and ask participants to query all their cancer-related concerns in the chatbot.

Eligibility criteria:
inclusion criteria: * aged 18 and above * are able to read and speak cantonese or mandarin fluently * have a new, primary diagnosis of head and neck/laryngeal cancer * are waiting to receive a full course of curative-intent, external beam radiotherapy with or without chemotherapy * have a karnofsky performance score ≥70 * have distress scored 3 or above on the nccn distress thermometer exclusion criteria: * insufficient command of chinese * have any other factors precluding the ability to give informed consent or comply with the protocol

Keywords: chatbot digital health oncology care
post-op treatment with hyaluronic acid injections

Conditions: Meniscus Tear; Chondropathy/Degenerative Joint Disease (DJD)

Summary: this study will look at patients with post-operative treatment of a meniscal tear or degenerative joint disease (degenerative arthritis). they will be randomized into one of three groups: euflexxa injection, saline (placebo) injection, or no injection. those who are randomized into the injection group will receive a series of three injections (one a week for 3 weeks), then a "booster" injection at 6 months post-op. several questionnaires will be given after the first set of injections, then again at a one year follow-up. the hypothesis is that patients receiving hyaluronic acid injections will have better pain and function scores as compared with placebo and no further treatment at all time points.


Eligibility criteria:
inclusion criteria: * patients in post-op stage of treatment for meniscal tears or chondropathy/djd * over 40 years of age * a daily knee pain above 20mm on a 100mm visual analogue scale exclusion criteria: * previous recipient of viscosupplementation injections * had rheumatoid arthritis or other inflammatory arthritis * had intra-articular steroid injections within the previous 2 months * invasive knee procedures within the past 6 months * contraindications to hyaluronate (an allergy) * medications that could interfere with the planned interventions

Keywords: viscosupplementation meniscus tear degenerative joint disease