Kornimate/medical-research-clean huggingface dataset:
intervention for victimized youth

Conditions: Victimization

Summary: ivy (intervention for victimized youth). just as ivy plants are strong and can flourish in difficult environments, the goal of ivy will be for targets of peer victimization to thrive academically and socially despite challenging circumstances.

the project involves the development of a virtual intervention program for targets of peer victimization. intervention for victimized youth (ivy) will improve upon many limitations of existing interventions described above since it is the first intervention program to specifically address the needs of targets of peer victimization from a trauma perspective. moreover, it addresses key limitations of cbits and increases the flexibility of the intervention by using a virtual delivery model. just as ivy plants are strong and can flourish in difficult environments, the goal of ivy is for victimized youth to thrive academically and socially despite challenging circumstances. ivy uses a cognitive behavioral therapy (cbt) approach to address current distress due to peer victimization and teach strategies for handling any future peer victimization. common elements of effective cbt-based trauma treatments are psychoeducation, emotion regulation skills, imaginal or in vivo exposure, cognitive processing, and/or problem solving. several methods are used within sessions to teach the content, including psychoeducation, didactic teaching, modeling, role playing, and guided self-reflection. the proposed 8-week intervention. the focus of the first 4 sessions will be on teaching skills to help students overcome emotional difficulties associated with being victimized. weekly topics include: 1) introduction \& psychoeducation, 2) emotional regulation skill building and practice, 3) identifying \& coping with difficult thoughts and emotions, and 4) connecting thoughts, emotions, and behaviors. the last 4 sessions are specific to peer victimization issues with a focus on avoiding re-victimization since victimized youth often are victimized repeatedly and report that they defend other victims. weekly topics include: 5) options for protecting yourself, 6) social problem-solving skills, 7) adaptive thinking, and 8) future planning \& celebration. participants will be taught several options for intervening. a decision-making process for evaluating social situations will be taught. based on the outcome of that decision-making process, participants will be taught options for responding with the goal of avoiding re-victimized.

Eligibility criteria:
inclusion criteria: * current middle school student in us (defined as grades 6, 7, or 8) * experience at least one instance of peer victimization in past month * have elevated or extremely elevated social-emotional distress score, as measured by the bess (behavior and emotional screening system) exclusion criteria: * not current middle school student * not experience victimization in past month * no elevated score on bess

Keywords: peer victimization bullying trauma
the london copd exacerbation cohort

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the london copd exacerbation (excel) cohort builds on an established cohort started in 1995 and designed to study copd exacerbations and their impact on health-status and disease progression.

our intentions are to phenotype chronic obstructive pulmonary disease (copd) patients on the basis of factors that a related to (a) exacerbation frequency which will include (b) lung function to assess disease severity, (c) baseline therapy, (d) airway and systemic inflammatory markers, (e) health status, (f) gene expression, (g) airway bacterial and viral load and (h) co-morbidity including cardiovascular disease, diabetes and psychological disease, (i) psychological factors,(j) mortality, (k) nasal susceptibility to rhinovirus infection, (l) heart rate variability (m) exhaled hydrogen sulphide.

Eligibility criteria:
inclusion criteria: * forced expiratory volume in 1 sec (fev1)/forced vital capacity (fvc) ratio of \<0.70 * able and willing to give informed and written consent exclusion criteria: * patients with a history of asthma, bronchiectasis, carcinoma of the bronchus, or other significant respiratory disease were excluded. * patients on immunosuppressive medications or with active cancer * long term steroid therapy * age \<40 years at recruitment

Keywords: chronic obstructive pulmonary disease
study of anti-atherosclerotic and estrogen-like activity of karinat in perimenopausal women

Conditions: Menopausal Syndrome; Atherosclerosis

Summary: the purpose of this study is to investigate the anti-atherosclerotic and anti-climacteric action of natural drug karinat based on phytoestrogen-rich botanicals in perimenopausal women.


Eligibility criteria:
inclusion criteria: * perimenopausal women aged 45 to 60 years with intact womb and ovaries * the absence of menstruations between 6 to 24 months * last menstruation after the age of 40 years * follicle-stimulating hormone (fsh) blood level ≥ 35 ng/ml * mammography without nodal form of mastopathy or breast cancer signs * absence of hypolipidemic therapy or hrt (hormone replacement therapy) during 6 months before the inclusion exclusion criteria: * administration of lipid-lowering drugs, and/or hrt, and/or phytoestrogens during 6 month before inclusion * personal history or diagnostic of following diseases: nodal form of mastopathy or breast cancer any cancer except non-melanoma skin cancer stroke or myocardial infarction chronic renal failure ii-iii chronic hepatic failure ii-iii liver cirrhosis chronic heart failure iia-iii exacerbation of chronic stomach or duodenal ulcer obesity (bmi \>30 kg/m2) alcohol abuse uncontrolled arterial hypertension (systolic blood pressure \> 160 mmhg, diastolic blood pressure \> 90 mmhg) current cigarette smoking (\>10 cigarettes a day) diabetes mellitus deep vein thrombosis or pulmonary embolism * individual intolerance of karinat or major side effects

Keywords: perimenopause phytoestrogen atherosclerosis intima-media thickness
early speech with one-way speaking valve in tracheostomy patients

Conditions: Respiratory Failure; Speech; Aphonia

Summary: patients with tracheostomy who are on and off of mechanical ventilation initially lose the ability to speak, and the use of one-way speaking valves (owsv) is one method of restoring speech in these patients. patients with tracheostomy who experience loss of speech report frustration and feelings of confinement from patients' communication impairment, therefore investigators would like to restore speech in these patients as soon as it is safe to do so. however, there is currently little known in the literature about the timing of the use of owsv in patients with tracheostomy. therefore, the investigators propose a pre-test post-test clinical trial pilot study to investigate the safety of early use of owsv in patients undergoing a percutaneous tracheostomy. study aims are to identify patients who would benefit from the early use of owsv and to determine the effects of early use of owsv on speech and clinical outcomes. to achieve these aims, patients who undergo percutaneous tracheostomy will be screened, and patients meeting screening criteria will be randomized into intervention and control groups. the intervention group will receive early speech-language pathology (slp) evaluation and owsv trial at 12-24 hours following tracheostomy procedure, and the control group will receive standard slp evaluation and owsv trial at 48-60 hours following tracheostomy procedure. intervention and control groups will been compared on speech and clinical outcomes measures from pre-test at 12-24 hours following tracheostomy and post-test at 48-60 hours following tracheostomy and characteristics of patients who successfully tolerate early owsv use will be identified.


Eligibility criteria:
inclusion criteria: * patient who received a percutaneous tracheostomy * glasgow coma scale score ≥9 * confusion assessment method -icu (cam-icu): negative * richmond agitation sedation scale (rass): -1 to +1 * able to understand english exclusion criteria: * open tracheostomy * laryngectomy * presently using owsv or capped trach * foam-filled cuffed tracheostomy tube * presence of known severe airway obstruction * presence of post-operative bleeding requiring transfusion or packing * presence of air-leak around the cuff resulting in respiratory decompensation

Keywords: tracheostomy quality of life speaking valve speech mechanically ventilated patients
versius or laparoscopic transabdominal inguinal hernia repair

Conditions: Inguinal Hernia

Summary: this trial will compare laparoscopic and robotic-assisted inguinal hernia repairs, using the versius® system. we will initially aim to recruit 60 patients (20 patients in the laparoscopic arm and 40 in the robotic arm) in order to assess the ergonomic impact of each modality on the operating surgeon. this aims to provide in vivo information on whether robotic surgery provides any advantages to the operating surgeon. this trial will also be used to assess the feasibility of recruitment to a future larger study, and any data collected will be used as pilot data.

this study has been designed to assess the ergonomics of versius® assisted surgery in comparison with laparoscopic surgery in the management of inguinal hernias. the study will randomise 60 patients who require repair of an inguinal hernia and have been deemed suitable for a minimally invasive approach. patients will be randomised to receive either laparoscopic or versius® robotic assisted surgery but will be informed that it will be attempted via a minimally invasive approach that could include either of these two subtypes of minimally invasive surgery. the randomisation will occur on a 2:1 basis, with 2 patients allocated to the robotic arm for every 1 patient allocated to the laparoscopic arm. laparoscopic surgery is already a well-established technique, and therefore the study team believe more valuable data about the outcomes of robotic surgery will be obtained with this randomisation ratio given that no prior studies have been undertaken using this robotic platform. all surgeons in the study will be required to have been involved in at least 20 cases performed using the relevant modality, whether for the robotic or laparoscopic cohorts. data will be collected at four key timepoints; recruitment, intraoperatively, at discharge and again at 14 days following intervention. feasibility outcomes will include willingness to be recruited to study (acceptability), willingness for patient to undergo desired randomised operative approach (acceptability/concordance), withdrawal of patients (non-concordance), study retention (retention rates), and the usefulness and limitations of outcome measures.

Eligibility criteria:
inclusion criteria: * age ≥18 years * need for inguinal hernia repair surgery * deemed suitable for minimally invasive surgery exclusion criteria: * patients who are unable to consent * prisoners * patients in need of emergency surgery * patients with inguinoscrotal or recurrent inguinal hernias

Keywords: surgery ergonomics robotics
reinitiation of anticoagulation after temporary withdrawal of vitamin k antagonist

Conditions: Atrial Fibrillation; Venous Thromboembolism; Heart Valve Disease; Surgery

Summary: it is not known how to best restart warfarin after temporary withdrawal. participants will be randomized to two groups. group 1 will restart warfarin at their usual maintenance dose, group 2 will restart warfarin at double their maintenance dose for two days followed by their usual maintenance dose. the main outcome parameter will be the number of patients who are back in therapeutic inr (international normalized ratio) range 4, and 9 days after restarting anticoagulation with warfarin. thromboembolic and/or bleeding events will be recorded as additional parameters. these data will be collected by a standardized telephone interview at 1 month. in addition, the investigators will evaluate a possible prothrombotic state by measuring the potential of thrombin generation and d-dimers in the subset of patients visiting hhs-general hospital for their inr tests.

we will investigate if it is feasible to use double maintenance dose for the first two administrations of vitamin k antagonists when these drugs were temporarily interrupted and thus keep the time of an increased risk of thromboembolism and duration of "bridging" at a minimum. the control group will consist of patients who resume vitamin k antagonists at their usual maintenance dose. the aim of the study is to establish how to best restart anticoagulation with vitamin k antagonists after temporal withdrawal of these drugs. the main outcome parameter will be the proportion of patients who are back to a therapeutic international normalized ratio (inr) ratio at certain days after restarting vitamin k antagonists. two additional parameters will be evaluated: firstly, bleeding and thromboembolic complications will be reported and secondly, a possible prothrombotic state, measured as an elevation of d-dimer, at the initiation of anticoagulation will be evaluated.

Eligibility criteria:
inclusion criteria: * current treatment with warfarin * need for temporary interruption for invasive procedure or surgery exclusion criteria: * need for post-operative hospitalization more than one day * participation in another clinical trial * no consent given

Keywords: warfarin surgery management thromboembolism bleeding
closed-loop tacs modulation for the core clinical features of drug addiction

Conditions: Amphetamine Use Disorders

Summary: using specific eeg biomarkers in methamphetamine-dependent individuals, this study systematically probes the effect of closed-loop tacs based on brain states

the current study delineates a robust correlation between prefrontal cortex eeg signals and the psychological craving associated with methamphetamine usage. dependents exhibit heightened β oscillation energy in the mpfc region and diminished γ oscillation energy across the dlpfc-mpfc region. previously, through the implementation of rtms interventions on the left dlpfc, the investigators have successfully reduced the craving levels in users when exposed to relevant cues, coupled with observed decreases in β oscillation energy and increases in γ oscillation energy in the mpfc region. this indicates that both β and γ oscillation energies are instrumental in representing the involvement of mpfc and dlpfc during craving episodes, and neuromodulatory technologies can modulate these energy levels, consequently reducing cravings. furthermore, the investigators identified a significant augmentation in the theta energy in the occipital lobe when ma dependents are confronted with drug-related cue imagery, signifying a potential crucial neural marker for addiction-induced brain activity. therefore, the investigators intend to employ the non-invasive transcranial alternating current stimulation (tacs) technique, predicated upon biomarkers of addiction states, to administer specific frequency stimulations to targeted brain regions, aiming to achieve therapeutic objectives in addiction treatment.

Eligibility criteria:
inclusion criteria: individuals aged between 18 and 45 years, irrespective of gender, having completed a minimum of 9 years of education and capable of effectively cooperating in questionnaire evaluations. meet the diagnostic criteria set forth by the dsm-v concerning the severity of amphetamine-type substance addiction. a history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week. consent to actively cooperate in the completion of subsequent follow-up assessments. exclusion criteria: severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an iq score less than 70. a diagnosis of schizophrenia or other severe mental illnesses as per the dsm-5 criteria. abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years. severe organic diseases that might compromise study participation. contraindications to tacs, such as a history of epileptic seizures or the presence of metallic implants in proximity to the head.
hibiscus sabdariffa and centella asiatica in the treatment of anemia by iron deficiency

Conditions: Iron Deficiency Anemia

Summary: the study aims to investigate the prevalence of genetic polymorphisms in adults with iron deficiency and anemia, and the responses to two different treatments: iron sulphate and a composite herbal medicine (hibiscus sabdariffa plus centella asiatica). the main outcome will be hemoglobin, measured before and after 6 weeks.


Eligibility criteria:
inclusion criteria: * age \> 18 y and \< 50 y * a diagnostic of iron deficient anemia exclusion criteria: * severe anemia * treatment interruption for more than 25% of the 6 weeks * new onset severe adverse symptoms or events * patient's request

Keywords: iron anemia herbal medicine phytotherapy centella asiatica hibiscus sabdariffa
improving mobility in diabetic patients through resistance training

Conditions: Diabetic Patients With Polyneuropathy

Summary: impaired mobility is a major health problem affecting many subjects with diabetes mellitus. it is associated with loss of quality of life and it is a strong predictor for poor health outcomes. reduced lower extremity muscle function, as a consequence of diabetic polyneuropathy, is a major cause of impaired mobility. we hypothesize that a programme of resistance training will counterbalance the effects of polyneuropathy on muscle wasting, and will improve mobility and associated quality of life. the objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. it is also our intension to achieve a better understanding of the relation between diabetic neuropathy and muscle weakness, limited mobility and quality of life. moreover, insight will be gained in optimizing training programmes for neuropathic patients.


Eligibility criteria:
inclusion criteria: * diabetic patients with polyneuropathy: * valkscore \>5; * diabetic type 2; * age \>50 years exclusion criteria: * muscular related diseases; * ischemia; * amputation (except for toe amputation)

Keywords: muscle strength physical activity mobility gait analysis
study on susceptibility genes and pathogenic mechanism of non-syndromic familial aortic dissection

Conditions: Aortic Dissection; Family Research; Aortic Dissection, Familial, With or Without Aortic Aneurysm

Summary: aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. the related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. in this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.


Eligibility criteria:
inclusion criteria: * family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included; exclusion criteria: * pedigree exclusion criteria: pedigree members have marfan syndrome, loeys-dietz syndrome, ehler-danlos syndrome, aneurysm-osteoarthritis syndrome and other syndroms

Keywords: aortic dissection pathogenesis familial inheritance susceptibility gene
impact of "telecoaching program" on physical activity in patients with copd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the purpose of this 3 month randomized intervention study is to investigate the additional effect of a physical activity telecoaching program on physical activity in patients with copd, compared with usual care.

in this 3 month, randomized (1:1 ratio), parallel-group, multicenter trial, patients in both groups (control and coaching) will receive information and guidance on the benefits associated with increased physical activity in copd patients and their health status. patients in both groups will use two proactive monitors (actigraph® and dynaport®) and a pda to complete the proactive questionnaire. in addition to above, the patients in the coaching group will receive daily coaching by a semiautomated system and coaching by the investigator during study visits.

Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment is performed * male and female patients ≥ 40 years of age * diagnosis of copd (gold criteria: post bronchodilator fev1/fvc\< 70%) * current or ex-smokers with a smoking history equivalent to at least 10 pack years * patient should have at least 4 days of physical activity data recorded via proactive monitors during 7 days prior to the baseline measurement exclusion criteria: * orthopedic, neurological or other complaints that significantly impair normal biomechanical movement patterns, as judged by the investigator. specifically if the patients' condition/ co-morbidities are such that physical activity cannot be increased, then they should not be enrolled * respiratory diseases other than copd (e.g. asthma) * cognitive reading impairment and/or difficulties to manage electronic devices precluding interaction with the smartphone and pda, as judged by the investigator * participating in or scheduled to start an outpatient rehabilitation program during the study. if the patient wishes to participate in pulmonary rehabilitation for any reason the patient can be enrolled in the study only at the end of rehabilitation

Keywords: chronic obstructive pulmonary disease (copd) physical activity proactive telecoaching