Kornimate/medical-research-clean huggingface dataset:
igf-1 treatment for individuals with short stature due to papp-a2 deficiency

Conditions: Short Stature

Summary: with this study we want to investigate the pharmacokinetic (pk) effect of a single injection of rhigf-1 in patients with papp-a2 mutations compared to heterozygous carriers and healthy controls. this will be followed by treatment of papp-a2 deficient patients with igf-1 for a period of one-year to assess growth velocity. additionally, we want to further describe the phenotypic characteristics of patients with papp-a2 deficiency.

the 24-hour pharmacokinetic response of free and total igf-1 and igf binding protein-3 (igfbp-3) to a single dose of rhigf-1 (120 mcg/kg) in three patients with papp-a2 mutation compared to up to four unaffected heterozygous relatives and 2 healthy adult controls. one-year trial of rhigf-1 at standard dose given to the two youngest males with papp-a2 mutation. the primary end point of this trial will be first year height velocity. secondary outcomes will include height standard deviation score (sds), height velocity, and whole body and lumbar spine bone mineral density assessment. the study was amended to extend the treatment period to continue until the subject has stopped growing (or elects to withdraw). all study procedures remain the same. important note: the treatment phase continues to follow the youngest affected male. the older affected male developed an adverse event that resulted in discontinuation of treatment. a post-treatment follow up visit (either in-person or remote) will be completed for the study participant who remained on increlex approximately one-year after their discontinuation of therapy. description of additional phenotypic characteristics of patients with papp-a2 mutation will be studied by collecting information on glucose and insulin metabolism, body composition, bone geometry and bone density before and after treatment with rhigf-1. these measures will be collected at the 12-month time period, and every year thereafter until the completion of the study. all three affected siblings will take part in the phenotyping activities.

Eligibility criteria:
papp-a2 deficient inclusion criteria: * defect in papp-a2 (heterozygous or homozygous mutation) exclusion criteria: * none healthy volunteers inclusion criteria: * between the ages of 18 and 30 * in general good health exclusion criteria: * any medications (with the exception of contraceptives) * pregnancy
penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation

Conditions: Ischaemic Stroke

Summary: stroke affects over 125,000 people each year in the uk and leaves at least 50% disabled. treatment of stroke caused by a blockage in a blood vessel (ischaemic stroke), with clotbusting drugs improves the chances of good recovery, but must be given within 4.5 hours of onset. currently only a small proportion of patients who arrive in hospital within 4.5 hours are treated. this is largely due to uncertainty about diagnosis and concerns about risk of bleeding associated with clotbusting medication. patients with mild or improving symptoms in particular are often not treated because of uncertainty about relative risks and benefits. however, around one third of these patients go on to be significantly disabled. routine ct scanning often does not show abnormalities in acute stroke (which take hours to become easily visible), and cannot show the extent or severity of blood flow changes in ischemic stroke. we wish to investigate the value of additional ct scanning that gives information on the blood vessels (angiography, cta) and blood flow to the brain (perfusion, ctp) by undertaking a randomised trial. extra scans are done in the same scanner and involve some extra radiation, injections of a contrast dye, and some extra time to acquire process and interpret. the extra scans may allow better treatment decisions for patients by increasing diagnostic certainty and by better assessment of stroke severity. however, we do not know whether the potential gains from better selection justify the resources and potential treatment delays that are involved. we will investigate whether the proportion of patients given clotbusting drugs differs between the two scanning protocols; and whether the outcomes differ, using standard measures of disability. we will also investigate whether use of different scanner manufacturers' software affect interpretation of scans.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of stroke eligible for iv rtpa according to current guidelines * informed consent * male or nonpregnant female ≥18 years of age * within 4.5 hours of onset as defined by time since last known well exclusion criteria: * contraindications to thrombolytic drug treatment for stroke * pregnancy * known impaired renal function precluding contrast ct * known allergy to ct contrast agents * severe concurrent medical condition that would prevent participation in study procedures (e.g. cardiac failure with severe pulmonary oedema) or with life expectancy ≤ 3 months.
testing of medication dosing software

Conditions: Pediatric Emergency Medicine

Summary: the goal of this clinical study is to evaluate the clinical efficiency of a medication dosing software in simulated pediatric emergency care. the main questions it aims to answer are: * will the time to patient be significantly reduced with the medication dosage software when compared to standard clinical practice? * will the time to calculate dosage of medications be significantly reduced with the medication dosage software when compared to standard clinical practice? * how will users perceive clinical efficiency, ease of use, confidence level of using the medication dosage software when compared to standard clinical practice? * how will accuracy of medication dose and volume calculations as well as final volume ready for administration using the medication dosage software compared to standard clinical practice? * will the time spent calculating medication doses by the second healthcare professional on pediatric non-acute and acute care cases be significantly reduced with the medication dosage software when compared to standard clinical practice? participants will be presented pediatric care scenarios and asked to calculate and prepare intravenous medications under two interventions: the medication dosage software and standard clinical practice (lexicomp and manual calculator).


Eligibility criteria:
inclusion criteria: -healthcare professionals who have worked or who are currently working at a healthcare facility and involved in the calculation or preparation of iv medication. exclusion criteria: * healthcare professionals who cannot read, speak, or understand english or french as the simulations will be conducted in english or french. * performance of physically strenuous activity 30 min prior to study. * physical limitations that affect performance on required tasks (e.g., inability to place arm cuff on mannequin's arm, inability to handle weight estimation and touchscreen devices).

Keywords: simulation pediatric emergency care healthcare professionals medication errors
clinical study to evaluate the safety and efficacy of heating and cooling combination therapeutic device(och-s100)

Conditions: Chronic Low Back Pain

Summary: the purpose of this study is to verify the efficacy and safety of heating and cooling combination therapeutic device (och-s100) for patients with chronic low back pain (lbp).

the investigators targeted the patients with chronic lbp. after treatment in 2 groups - real heating and cooling combination treatment and sham heating and cooling combination treatment - the investigators will compare the effects of pain relief and improvement in disability and range of motion of lumbar region. so the investigators will confirm the efficacy of heating and cooling combination therapy, and further the best treatment method. in addition, the investigators are going to evaluate the safety of abnormal reaction during the treatment.

Eligibility criteria:
inclusion criteria: 1. at least 20 years of age, but below 75 years of age 2. low back pain in the last 3 months or more 3. low back pain rated over 40 mm on a 100 mm visual analog scale (vas) 4. those who are reliable and willing to cooperate in this test, and obey the restrictions for the treatment period. 5. an understanding of the objectives, methods and efficacy of the clinical trial, and willingness in completing the consent form. exclusion criteria: 1. trauma to or surgery on the lumbar region within 6 months prior to enrollment 2. low back pain accompanied by sciatica 3. systematic disease, and severe dysfunction due to the medical illness (e.g. cancer, infection, etc.) 4. a history of medication, oriental medical treatment, physiotherapy for treating low back pain within the last 4 weeks 5. neurological disease, such as topical or whole body hypoesthesia in temperature sensation (e.g. stroke, peripheral neuropathy, etc.) 6. hypersensitivity in heating and cooling stimulation 7. pregnant and lactating women 8. participate in the other clinical trials within the last 3 months or after enroll this trial 9. when researchers evaluate that it is not appropriate to participate in this clinical test

Keywords: chronic low back pain heating and cooling combination therapeutic device heating and cooling combination therapy contrast therapy
the clinical and laboratory characteristics of recurrent drug- related hyponatremia

Conditions: Hyponatremia; SIADH

Summary: the aim of this study is to identify factors associated with hyponatremia among patients hospitalized in the internal medicine ward. consequtive patients hospitalized because of hyponatremia will be recruited. follow up will include clinical factors such as background diseases, complete drug history, blood tests including biochemistry tests (sodium, renal function), endocrinological evaluation, thyroid function tests, cortisol,urinary sodium on addmition. one month following discharge follow up sodium level will be taken.


Eligibility criteria:
inclusion criteria: * patients hospitalized to the internal medicine ward due to hyponatremia exclusion criteria: * none
a prospective randomized controlled study comparing the clinical effects of surgical and non-surgical treatment of low rib fractures

Conditions: Rib Fracture Multiple

Summary: the purpose of this study is to explore the difference between the clinical effects of surgical and non-surgical treatment for patients with low rib fracture, and to explore whether ssrf has more clinical treatment advantages in patients with low rib fracture in a randomized, controlled and prospective manner.


Eligibility criteria:
inclusion criteria: * patients with chest trauma only and unilateral low rib fractures three rib fractures and more displacement of the broken end of the fracture (bicortical fracture and not in the same line) time from injury to hospital \ 60mmhg, carbon dioxide partial pressure \ 5 under calm breathing exclusion criteria: * difficult airway history of esophageal reflux myasthenia gravis coagulation disorders gastrointestinal ulcer gastrointestinal bleeding anesthetic drugs allergy history asthma chronic obstructive pulmonary disease pregnant women
transversus abdominis muscular training and chronic low back pain

Conditions: Low Back Pain

Summary: low back pain is not a diagnosis; it is a symptom describing the presence of pain in the lumbar vertebral or paravertebral region without any reference to the structure or cause of the process. it is one of the most widespread diseases and one of the most common reasons for visits in primary care setting. exercises to improve lumbar stability involving co-contraction of the transversus abdominis have proved to be effective in reducing pain and improving function. it has been stated by ultrasound images that specific stabilization exercises cause contraction of the deep abdominal muscles, but it remains unclear whether training produce thickness muscle improvement and if this improvement is related to clinical findings. to try to resolve this issue a project of an experimental trial, double-blind (patient and evaluator) with two groups randomly assigned is presented. all participants will be recruited in an primary care center of the catalan health institut and will sign informed consent. all will receive a protocolized treatment with therapeutic exercises and thermotherapy and, additionally, those assigned to the intervention group were instructed in performing lumbar stability exercises. pain (vas), function (roland-morris questionnaire) and the thickness of the transversus abdominis, internal and external oblique muscles (measured by ultrasound) at baseline, end of treatment protocol (12 sessions) and three months after the end of treatment will be assessed. results in pain, function, and its correlation with the mean changes in the thickness of transversus abdominis will be analyzed.


Eligibility criteria:
inclusion criteria: * 18 years old and over * diagnosis of chronic low back pain (over 3 months) * sign the informed consent form. exclusion criteria: * non-stand supine position * neural irradiation pain * previous surgical intervention in low back region * heart pathology * pregnancy * pending litigation or legal claim * poor language and communication skills making difficult to understand the informed consent
controlling myopia progression with soft contact lenses

Conditions: Myopia

Summary: this study is to investigate whether novel soft contact lens optical designs can slow myopia progression.

the study will be a prospective, randomized, single blind, bilateral dispensing study

Eligibility criteria:
inclusion criteria: 1. myopic subjects between 8 and 12 years of age. 2. the subject best sphere contact lens correction must lie between -0.75d (best of the two eyes) and -5.00d (worst of the two eyes) 3. astigmatism must be less than or equal to 1.00d 4. 1.00d or less difference in spherical equivalent between the two eyes 5. the subject must have a best-corrected visual acuity of 0.8+2 (20/25+2) and spherical equivalent refraction visual acuity of 0.820/25) or better in both eyes 6. the subject must have at least 8d of accommodation 7. the subject and subject's parent or legal guardian must read and sign the staement of informed consent 8. the subject must appear able and willing to adhere to the instructions set forth in this clinical protocol. exclusion criteria: 1. any ocular or systemic allergies or diseases that may interfere with contact lens wear. 2. systemic disease or autoimmune disease or use of medication (e.g. antihistamine), which may interfere with lens wear. 3. clinically significant (grade 3 or 4)corneal edema, corneal vascularization, corneal staining, or any other abnormality of the cornea, which may contraindicate contact lens wear. 4. clinically significant (grade 3 or 4) tarsal abnormalities or bulbar injection that might interfere with contact lens wear. 5. any ocular infection. 6. any corneal distortion resulting from previous hard or rigid gas permeable contact lens wear. 7. any infectious disease (e.g., hepatitis, tuberculosis) or an immunosuppressive disease (e.g. hiv) 8. diabetes 9. anisometropia of greater than 1.00d 10. astigmatism of greater than 1.00d in either eye 11. eye injury or surgery within eight weeks immediately prior to enrollment for this study. 12. pervious refractive surgery, rigi contact lens wear, orthokeratology, keratconus or other corneal irregularity in either eye. 13. strabismus in either eye 14. pupil orr lid abnormality or infection in either eye 15. central corneal scar in either eye 16. aphakia in either eye 17. contraindications to contact lens wear such as dry eye or history of prior unsuccessful contact lens wear. 18. history of participation in prior clinical trials aimed to control myopia progression 19. surgically altered eyes, ocular infection of any type, ocular inflammation 20. subject has anterior chamber angle grade 2 or narrower
sienna+® injection time study 4 arms

Conditions: Breast Neoplasms

Summary: patients with breast cancer normally undergo a labelling with radioactive tracer typically 1 day before surgery, which enables the surgeon to localize the sentinel lymph node during surgery. this pilot study uses the magnetic sentimag technique to mark the lymph nodes either 1 or 4-6 days before surgery to investigate the concordance with the standard technique.

sienna+® is injected either 1 day or 4-6 days before surgery, either retro-mamillary or peri-tumorally: * sienna+® retro-mamillary 1 day before surgery: 10 patients * sienna+® peri-tumorally 1 day before surgery: 10 patients * sienna+® retro-mamillary 4-6 days before surgery: 10 patients * sienna+® peri-tumorally 4-6 days before surgery: 10 patients in each case, technetium as standard technique is employed according to the gold standard protocol one day before surgery. the sentimag device is used during surgery to detect the lymph nodes in parallel to the standard technique.

Eligibility criteria:
inclusion criteria: * subject has a diagnosis of primary breast cancer * subject has been scheduled for surgery with a sentinel lymph node biopsy procedure * subject is ≥18 years old at time of consent * subject has an ecog performance status of grade 0-2 * subject has a clinical negative node status * subject is available for the follow-up exclusion criteria: * subject is pregnant or lactating * subject has a radiological evidence of metastatic cancer * subject has had previous axilla surgery or reduction mammoplasty * subject has impaired lymphatic function * subject has had a preoperative radiation therapy * subject has iron overload disease or iron/dextran intolerance * subject has a pacemaker * subject is under guardianship

Keywords: breast cancer sentinel node sentinel node biopsy breast surgery
bridging generations: educating children on dementia and fall prevention through animation

Conditions: Fall Prevention in Healthy Aging

Summary: a retrospective data review was conducted on a case-control trial involving 60 children (29 boys, 31 girls) as part of a public education initiative hosted on the web-based platform "hand in hand across barriers - public education platform" (facebook).

the program consisted of short, age-appropriate animated narratives reflecting three home-fast domains: (1) home environment and furniture, (2) capability in activities of daily living, and (3) use of devices. pre- and post-intervention assessments included knowledge quizzes and caregiver-supported completion of the 74-item pictorial hssat v.5 checklist.

Eligibility criteria:
inclusion criteria: * full time students exclusion criteria: * know neurological disorder

Keywords: fall
cognitive training and enhanced supported employment in schizophrenia

Conditions: Schizophrenia

Summary: this study will evaluate the effectiveness of a computer-based cognitive enhancement program plus a work therapy program at improving productivity, work performance, and quality of life in schizophrenic individuals.

schizophrenia is a chronic, severe, and disabling brain disorder that affects 2.4 million people in the united states. individuals with schizophrenia may have difficulties with cognitive functioning, including problems with attention, memory, and organizational thought processes. these factors can lead to decreased productivity and poor work performance, which may make holding a job difficult. research has shown that certain types of psychological therapies, such as cognitive behavioral therapy, are useful in reducing the severity of schizophrenic symptoms. the purpose of this study is to determine whether a computer-based cognitive enhancement training program, in combination with a work therapy program, will enhance workplace performance, productivity, and quality of life in individuals with schizophrenia. this study will enroll individuals with schizophrenia or schizoaffective disorder. participants will undergo a cognitive assessment at baseline. they will then be randomly assigned to either a 12-month cognitive enhancement training program plus a 12-month work therapy program or a 12-month work therapy program alone. participants in the cognitive enhancement training program will receive feedback on their cognitive strengths and weaknesses based on the outcomes of the baseline assessment. the training component will be comprised of 150 computer-based exercises that focus on improving memory, attention, and organizational skills. participants will attend two weekly meetings: one will focus on providing feedback regarding goal-setting and problem-solving, and the other will focus on improving verbal skills and social information processing. individuals taking part only in the work therapy program will attend two non-cognitive discussion groups per week. all participants will work up to 20 hours a week in an approved work environment, and will have access to appropriate support services. following the end of the program, participants will have the option of working an additional 12 months. schizophrenia symptoms, quality of life, and neuropsychological and rehabilitation effects will be assessed at the end of years 1 and 2.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or schizoaffective disorder exclusion criteria: * hospitalized in the 30 days prior to study entry * homeless in the 30 days prior to study entry * changed medications in the 30 days prior to study entry * substance abuse in the 30 days prior to study entry * history of head trauma

Keywords: schizoaffective disorder schizophrenic disorders psychotic disorders cognition
epidural contrast flow patterns of tesi using the inferior-anterior position as the final needle tip position.

Conditions: Lumbosacral Radiculopathy; Lumbar Herniated Nucleus Pulposus

Summary: the purpose of this study is to describe the contrast flow patterns in the epidural space using the inferior-anterior approach with continuous fluoroscopic guidance, and determine how well this approach correlates with appropriate contrast flow patterns and with analgesia at follow up. this knowledge may prove useful in guiding physician practice patterns in the non-surgical management of low back pain. hypothesis: the investigators hypothesize that there will be suitable (ventral/anterior) epidural contrast spread based on inferior-anterior needle-tip position, particularly with appropriate needle tip position.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * history of lumbosacral radiculopathy or lumbar herniated nucleus pulposus * scheduled for tfesi at gw spine and pain center exclusion criteria: * pregnant or plan on becoming pregnant * have undergone tfesi in the past year * opioid habituation * lumbo-sacral stenosis * lumbar surgery * lumbar spondylolisthesis

Keywords: transforaminal epidural steroid injections
comparison of ibuprofen, cyclobenzaprine, or both for acute cervical strain: a randomized clinical trial

Conditions: Cervical Strain

Summary: the purpose of this study is to see whether the combination of a muscle relaxant and anti-inflammatory drug is more effective at relieving pain in patients with neck strains or whiplash than either of the two medications alone.

muscle relaxants have been used extensively for neck and back pain since muscle spasm is thought to play a role in the cycle of pain and spasm. however, prior studies have conflicting results regarding their additive effect when given in addition to analgesics such as the nsaids. because they have the potential to lead to adverse events their efficacy should be clearly demonstrated before their routine use.

Eligibility criteria:
inclusion criteria: * neck pain within 24 hours of injury exclusion criteria: * children, allergy or contraindication to any of the study drugs

Keywords: cervical strain whiplash ibuprofen cyclobenzaprine