Kornimate/medical-research-clean huggingface dataset:
effectiveness of mindfulness-based cognitive therapy undergoing post stroke rehabilitation

Conditions: Stroke; Rehabilitation; Mindfulness

Summary: the goal of this clinical trial is to investigate the efficacy of mindfulness-based cognitive therapy compared to usual care for stroke survivors undergoing inpatient rehabilitation.

it was hypothesized that group-based mbct would lead to improving mood, mindfulness, social support, physical, and neurocognitive function; and that these improvements would be maintained over the 3-month follow-up period. participants in the control group received only usual care, the intervention group were involved in mbct intervention in addition to usual care. mbct intervention was designed to consist of eight 1.5-hour group sessions over 6 consecutive weeks.

Eligibility criteria:
inclusion criteria: * stroke patients with functional impairments * confirmation of stroke by ct or mri scan * age between 18-90 years * had adequate communication skills, cognitive and physical capacity to participate in study activities * competence to provide informed consent exclusion criteria: * severe cognitive impairment according to the word list learning instrument (total score \<7) * severe depression according to the beck depression inventory (bdi) (total score\>25) * history of severe mental illness (psychotic disorder, schizophrenia, severe depression, bipolar disorder, ptsd, suicidal tendencies) * the current change in the antidepressant therapy.
study of janx008 in subjects with advanced or metastatic solid tumor malignancies

Conditions: Non-Small Cell Lung Cancer; Renal Cell Carcinoma; Squamous Cell Carcinoma of the Head and Neck; Colorectal Carcinoma; Small Cell Lung Cancer; Pancreatic Ductal Adenocarcinoma; Triple-negative Breast Cancer

Summary: this study is a first-in-human (fih), phase 1/1b, open-label, multicenter dose escalation and dose expansion study to assess the safety, tolerability, pharmacokinetics (pk), pharmacodynamics (pd), and preliminary anti-tumor activity of janx008 in adult subjects with advanced or metastatic carcinoma expressing egfr.


Eligibility criteria:
inclusion criteria: * subjects ≥18 years of age at the time of signing informed consent * histologically or cytologically documented locally advanced or metastatic nsclc, scchn, crc, rcc, sclc, pdac, tnbc * progressed or was intolerant to all available therapies known to confer clinical benefit appropriate for the tumor type * adequate organ function * at least 1 measurable lesion per recist 1.1 exclusion criteria: * treatment with anti-cancer therapy within 28 days or ≤5 elimination half-lives, whichever is earlier, before enrollment * prior treatment with egfr-targeted bispecific t cell engager or car-t cell therapy * prior treatment with cd3 engaging bispecific antibodies * clinically significant cardiovascular diseases * active clinically significant infection (bacterial, viral, fungal, mycobacteria, or other) * on supplemental oxygen * any medical condition or clinical laboratory abnormality likely to interfere with assessment of safety or efficacy of study treatment
trial of cognitive behavioral therapy to reduce antiretroviral therapy side effects

Conditions: HIV Infections; Adverse Effects

Summary: the hypothesis is that participants in the intervention group will experience fewer/less intense side effects from anti-hiv medications, if they receive training sessions on the use of guided imagery, relaxation, and reframing of the medication-taking experience. such training is not part of the usual care of hiv patients.

hiv patients on antiretroviral medications, who are suffering from pain, nausea, anxiety, or fatigue will be randomly assigned to either the usual care for an hiv patient, which is an educational program about the medications, or an intervention program, which includes both the educational program and three sessions with a psychologist. the sessions will help participants understand their concerns about the medications and will teach relaxation techniques and guided imagery to help participants reduce discomforts associated with the medications. all patients will continue to receive the usual care from their medical providers. the main measures are the measured frequency and intensity of the symptoms under study; secondary measures examine medication adherence, cd4 counts, and virus levels. control measures include the number of doses of side effect medications taken in each group, and the number of relaxation/imagery sessions practiced privately by participants in the intervention group.

Eligibility criteria:
inclusion criteria: * participants currently taking antiretroviral medications for hiv * participants suffer from one or more: nausea, pain, fatigue, anxiety exclusion criteria: * non-english speaking/reading * pregnant or planning to become pregnant within 3 months * any severe health problem that would prevent participation (e.g., opportunistic infection requiring hospitalization) * substance abuse preventing active participation in care

Keywords: behavior therapy anti-retroviral agents relaxation clinical nursing research complementary therapies
prostin and propess in induction of labor

Conditions: Labor Pain

Summary: the purpose of the study was to compare the safety and efficacy of two agents used in induction of labor propess (controlled release dinoprostone, pge2, pessary) and prostin e2 (dinoprostone vaginal tablet).

a controlled release hydrophilic matrix (controlled therapeutics ltd., east kilbride, scotland) which provides a gradual release of dinoprostone (prostaglandin e2) was introduced in 1995 (propess, ferring pharmaceuticals). this preparation is used for the initiation or enhancement of cervical ripening in women at or after term with a singleton pregnancy and a cephalic presentation. prostaglandin e2 causes softening and dilatation of the cervix and subsequently produces uterine contractions which may induce labour.

Eligibility criteria:
inclusion criteria: * gestational age 37 weeks or more * singleton pregnancy * cephalic presentation. exclusion criteria: * previous cesarean section * any contraindication for vaginal delivery * suspected cephalo-pelvic disproportion * unexplained antepartum hemorrhage
monitoring noninvasively for infusion and transfusion optimization

Conditions: Post Operative Hemorrhage; Transfusion Related Complication; Blood Transfusion Associated Adverse Reactions; Hypovolemia

Summary: this is a multicenter, cluster randomized controlled trial to assess the effects of an optimized intraoperative fluid and blood management strategy on postoperative complications.


Eligibility criteria:
inclusion criteria: * 18 years or older at the time of consent. * ability to provide written informed consent. * scheduled for non-urgent major surgery with general anesthesia * at least one finger available and accessible for performing non-invasive pleth variability index (pvi) and hemoglobin (sphb) monitoring. * the attending surgeon, attending anesthesiologist and the clinical care team agree with enrollment in the study, including the restrictions on monitoring procedures defined in the control group. exclusion criteria: * untreated or uncontrolled hypertension defined as mean arterial pressure (map) greater than 120 mmhg, despite medications. * chronic kidney disease with glomerular filtration rate \<30 ml/min/1.73 m2 or requiring renal-replacement therapy for end-stage renal disease. * surgeries where no bleeding is expected to occur (i.e., total knee surgery where blood loss is prevented by use of tourniquet). * surgeries performed in the prone position. * acute cardiovascular event, including acute or decompensated heart failure and acute coronary syndrome. * aortic pathology that could lead to misinterpretation of hemodynamic variables (e.g. intra- aortic balloon pump, thoracic aorta aneurysm). * renal vascular surgery. * preoperative sepsis. * circulatory shock. * preoperative vasoactive substance infusion before study entry. * concurrent participation in any interventional study. * pregnant or lactating women. * patients who refuse to receive blood transfusion(s). * patients with do not resuscitate (dnr) orders. * open chest surgeries. * prisoners * patients for whom monitoring of co, sv, ppv, and/or svv to guide gdt or similar intra-operative fluid management, including continuous sphb monitoring, would be standard of care. * patients have skin abnormalities affecting the digits such as psoriasis, eczema, angioma, scar tissue, burn, fungal infection, substantial skin breakdown, nail polish or acrylic nails that would prevent the proper fit and application of the sensors. * cardio-pulmonary bypass (cpb) surgery.
chiropractic treatment of arthrogenic torticollis in infants; a retrospective study on outcome in 1000 infants

Conditions: Arthrogenic Torticollis

Summary: patient data is collected from previously treated patients and entered into the research electronic data capture (redcap).

already collected patient data (1995-2013) from a privat practice, is screened and entered into a individually design redcap form.

Eligibility criteria:
inclusion criteria: * arthrogenic torticollis * male or female age 3-12 month * treatment was conducted between 01/1995-12/2013 exclusion criteria: * uncompleted record * decline of further use of patient data
remote fetal monitoring in high risk pregnancies

Conditions: High Risk Pregnancy; Remote Patient Monitoring; Diabetes; Hypertension

Summary: antenatal nonstress tests (nsts) are performed to assess fetal health and are used as a cost-effective test that can be widely administered. however, an nst is operator-dependent due to the nature of doppler ultrasound and is primarily performed in a clinic and hospital setting. the ability to conduct a clinically valuable test at home would address access to care issues faced by numerous women in the united states and reduce the workload on healthcare clinicians facing a shortage of human resources. this pilot study aims to assess the feasibility and acceptability of home nst monitoring in order to determine whether femomtm could be utilized as an adjunct to routine prenatal care. patients with high risk pregnancies who are recommended to undergo at least once weekly at 32 weeks testing by the obstetrician will be recruited for participation in this study. participants will be asked to perform three 30 minute monitoring sessions weekly starting at 32 weeks for 6 weeks.

measuring fetal heart rate (fhr) through various methods is essential for assessing fetal wellbeing antenatally. this enables clinicians to identify patterns that could indicate fetal hypoxia. cardiotocography (ctg), which uses doppler ultrasound, is the gold standard for non-invasive fhr monitoring. this technology detects movement in the cardiac structures and approximates the fhr from this and requires signal modulation and auto-correlation to provide accurate quality readings of fhr. this method of external fhr monitoring is prone to signal loss, maternal fetal ambiguity where the maternal heart rate is confused for fhr, and signal artefacts (e.g., double-counting, and half-counting), during both antenatal and intrapartum monitoring, and must be performed by an obstetric provider. non-invasive fetal electrocardiography (nifecg) is a form of electrocardiography (ecg), which captures simultaneous maternal and fetal pqrst waves. nifecg has the theoretical benefits of minimizing maternal-fetal heart activity confusion, is not affected by maternal adiposity, and delivers no energy to the patient, which permits prolonged periods of fetal monitoring with safety. to date, nifecg has mostly been limited to research use due to low fetal signal-to-noise ratios. despite technical challenges, nifecg may be the most promising method of ambulatory self-applied fhr monitoring.

Eligibility criteria:
inclusion criteria: * intrauterine pregnancy greater than 32 weeks gestation * recommended for at least once weekly antenatal fetal testing by their obstetrician * english-speaking exclusion criteria: * under age 18 years of old * non-english speaking

Keywords: pregnancy non invasive testing remote patient monitoring
non-invasive mechanical ventilation in elderly patients

Conditions: Acute Respiratory Failure

Summary: the efficacy of nimv to treat harf has been widely demonstrated. however, in most of the studies performed in icus and in another facilities the mean age of the patients is usually less than 70 years. a multicentric, randomized-controlled trial conduced in a group of "elderly" patients with the mean age higher than 76 years, to compare the use of nimv with standard medical treatment (smt) in the treatment of an episode of acute hypercapnic respiratory failure.

non-invasive mechanical ventilation (nimv) has been successfully used in hypercapnic acute respiratory failure (harf) since endotracheal intubation (eti) and invasive ventilation are associated to high morbidity and mortality rate. because of the lack of beds in most intensive care units (icus) and the high mortality and cost associated with the increased of age, the "elderly" patients affected by arf due to chronic diseases are not always considered for eti. the efficacy of nimv to treat harf has been widely demonstrated. however, in most of the studies performed in icus and in another facilities the mean age of the patients is usually less than 70 years (see tab1). authors mean age (yrs) type of study bott \<80 copd niv vs medical therapy brochard71±9 copd niv vs medical therapy kramer 66±7 copd niv vs medical therapy andeev 63±4 copd niv vs medical therapy barbe 70±2 copd niv vs medical therapy bardi 68±8 copd niv vs medical therapy plant 69±8 copd niv vs medical therapy thys 71±8 copd niv vs sham niv nava 68±8 copd niv in weaning girault 63±14 niv in weaning ferrer 70±7 niv in weaning hill 71±3 copd pav vs psv confalonieri 66±14 pneumonia niv vs medical therapy martin 64±17 miscellaneous niv vs medical therapy conti 72±7 copd niv vs ei a multicentric, randomized-controlled trial conducted in a group of "elderly" patients with the mean age higher than 76 years, to compare the use of nimv with standard medical treatment (smt) in the treatment of an episode of acute hypercapnic respiratory failure.

Eligibility criteria:
inclusion criteria: * age higher 75 years old * hypercapnic acute respiratory failure (paco2 greater 50 mmhg and ph lower than 7.35) * respiratory rate (rr) higher 25 bpm after 12 hours of standard medical therapy. exclusion criteria: * respiratory failure due to pulmonary oedema * kelly's score equal or higher than 4 * cardio-respiratory arrest * systolic arterial blood pressure greater than 90 mmhg or severe arrhythmia * recent facial, oesophageal and gastric surgery

Keywords: old patients niv intubation copd
comparison of quality of life between patients underwent transoral endoscopic thyroid surgery and conventional surgery

Conditions: Quality of Life; Transoral Endoscopic Thyroidectomy; Conventional Thyroidectomy

Summary: the purpose of this study is to determine the quality of life of transoral endoscopic thyroidectomy compare with open thyroidectomy, furthermore, postoperative complication will be assessed, also.

regarding type of surgery, doctor will just advice about risk and benefit of any type of surgery. and then patient will select by himself. patients are not assigned to endoscopic or conventional group. this study start to enrolled patients after surgery. and the quality of life will be observed at 2, 6 and 12 weeks, respectively.

Eligibility criteria:
inclusion criteria: * patient who underwent thyroid lobectomy for benign thyroid nodule less or equal 5 cm exclusion criteria: * previous neck surgery * suspected thyroid carcinoma * patient who failure endoscopic thyroidectomy and change to conventional surgery

Keywords: endoscopic surgery thyroidectomy quality of life
clinical comparison of endodontically treated teeth restored with fiber posts or cast metal posts

Conditions: Post and Core Failure

Summary: there are few randomized controlled trials comparing intraradicular posts used to restore endodontically treated teeth, especially considering cast posts and glass fiber posts. the investigators study will evaluate the clinical success rates of endodontically treated teeth restored with glass fiber posts or cast posts and metal ceramic crown. individuals included in this study should present any tooth with endodontic treatment and need of intraradicular retention (post) on maxilla or mandible according to inclusion and exclusion criteria. individuals will be randomly allocated into two groups: (1) endodontically treated teeth restored with fiber post and composite resin core and metal ceramic crown or (2) endodontically treated teeth restored with cast post and core and metal ceramic crown. a sample size calculation will be performed to establish the number of posts needed for comparison. all crowns and posts will be cemented with self-adhesive cement. individuals will be examined by calibrated examiners, in years 1 to 3. the reason of failure will be categorized as root fracture, fracture of the post, post debonding, clinical and/or radiographical evidence of a gap between restoration and tooth or endodontic failure, tooth extraction, secondary caries, or marginal defects. the confidence level will be set in 95%.


Eligibility criteria:
inclusion criteria: * adult patients with normal occlusion with at least one teeth endodontically treated needing restoration exclusion criteria: * patients with malocclusion, * orthodontic devices, * temporomandibular disorders

Keywords: survival debonding endodontic treated teeth
trial of weight bearing status following femoral revision with tapered, fluted, titanium stems

Conditions: Postoperative Pain; Hip Arthroplasty

Summary: this is a prospective, randomized controlled trial of all patients undergoing femoral revision at thomas jefferson university hospital and rothman institute undergoing femoral revision surgery with the use of a modern titanium, fluted, tapered stem. at the time of surgery, patients will be randomized to six weeks of toe-touch weight bearing or immediate weight bearing as tolerated


Eligibility criteria:
inclusion criteria: * femoral revision patients with the use of a modern titanium, fluted, tapered stem. exclusion criteria: * include cemented fixation of the stem and patients with a tenuous acetabular reconstruction for whom the surgeon would like to protect weight bearing
effect of tourniquet on sensory nerve conduction threshold (snct) and oxyneurogram (ong) index- a volunteer study

Conditions: Sensory Nerve Conduction; Oxyneurogram Index

Summary: there are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application. there is some scientific evidence from animal studies demonstrating that prolonged tourniquet application can result in lack of oxygen supply to nerves, and subsequent nerve damage resulting in chronic pain. this theory has not been proven in humans. in this study the investigators will indirectly assess the evidence for abnormalities caused by tourniquet application on subjects' nerves using well established devices to determine the function of these nerves.


Eligibility criteria:
inclusion criteria: * healthy adults * over 18 years of age exclusion criteria: * neurological disease * diabetes mellitus * history of nerve injury * chronic pain * alcoholism * blood pressure measurements greater than 140/80 and infection in the monitored area

Keywords: tourniquet endoneural ischemia
comparison of insulin detemir and insulin semilente®mc in type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe. a 32-week efficacy and safety comparison of insulin detemir and insulin semilente mc in children between 6 and 21 years with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes * current intensified insulin treatment * injection of insulin semilente®mc at bedtime for at least 6 weeks * bmi maximum 32 kg/m\^2 * hba1c \> 5.5 % and \< 12.0 % exclusion criteria: * current treatment with premixed insulin(s) * impaired hepatic or renal function * recurrent major hypoglycaemia
personalized risk estimation for crohn's disease (pre-crohn's): implementation and feasibility

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Crohn Colitis; Crohn's Ileocolitis; Crohn's Gastritis; Crohn's Jejunitis; Crohn's Duodenitis; Crohn's Esophagitis

Summary: the aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for crohn's disease (pre-crohn's) tool on behaviors and biomarkers associated with risk for crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel disease. we hypothesize that personalized risk disclosure via the pre-crohn's educational tool is both feasible and successful in modifying behaviors associated with crohn's disease risk and normalizing pre-clinical disease biomarkers when compared to standard crohn's disease education. broadly, completion of this project will also help elucidate the role of lifestyle and dietary factors in pre-clinical crohn's disease development in high-risk individuals, and provide novel insight into potential strategies for disease prevention in this population.


Eligibility criteria:
inclusion criteria: * ability to give informed consent * ability and willingness to comply with all patient visits and study-related procedures * ability to understand and complete study questionnaires * must have at least one first-degree relative with inflammatory bowel disease (crohn's disease, ulcerative colitis, or indeterminate colitis/ibd unclassified) * individuals greater than 14 years of age exclusion criteria: * inability to provide informed consent * inability to comply with all patient visits and study-related procedures * inability to understand or complete study questionnaires * patients with existing diagnoses of inflammatory bowel disease (ulcerative colitis, crohn's disease, or indeterminate colitis/ibd unclassified) * evidence of clinical signs or symptoms of inflammatory bowel disease, identified by a modified version of the harvey-bradshaw index for cd activity

Keywords: crohn's disease