Kornimate/medical-research-clean huggingface dataset:
cognitive, affective, and motor effects of tangotherapy in parkinson's disease

Conditions: Parkinson Disease

Summary: neuroscientific research has shown a close relationship between physical fitness and cognition, showing a positive effect of physical activity (e.g., aerobic activity) on the maintenance of psycho-cognitive well-being in the elderly. in particular, dancing seems to be very effective, as it involves both motor and multisensory aspects (touch, sight, hearing, proprioception), stimulating memory, motor learning and social interaction. in fact, dance increases sensory-motor skills and cognitive performance in the neurologically healthy elderly. dance-based therapeutic approaches, in particular argentine tango, have also been implemented in the context of neurodegenerative pathologies, including parkinson's disease (pd) where motor (i.e., tremors, postural instability, motor slowdown) and cognitive difficulties (e.g., executive deficits) may coexist. most of these studies have so far demonstrated a significant improvement in balance and a reduction in motor symptoms, while evidence regarding cognitive and emotional benefits brought about by dance remains limited. when investigated, cognitive benefits have often been evaluated at the level of global cognition (i.e., screening tests), without a detailed characterization of the effects of tango on cognitive and affective functioning (e.g., executive functions, social cognition, depressive symptoms), central aspects in parkinson's disease.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild-moderate parkinson's disease (modified hoehn\&yahr scale 1-3) exclusion criteria: * having attended argentine tango classes in the past year; * having attended physical therapy rehabilitation in the past month; * other neurological diseases (e.g., stroke, traumatic brain injury, brain tumors) * dementia * any clinical condition not compatible with physical activity * deep brain stimulation of infusion pumps implants

Keywords: parkinson's disease argentine tango dance therapy cognition
angiomax® or unfractionated heparin for patients undergoing percutaneous coronary intervention

Conditions: Coronary Artery Disease

Summary: the objective of the study is to assess the safety and efficacy of angiomax® (bivalirudin) versus unfractionated heparin (ufh) in patients presenting with stable angina or silent ischemia (positive stress test without chest pain) that undergo percutaneous coronary intervention (pci). the primary endpoint of the study will be major and minor bleeding events, defined by the replace-2 trial definition, during the index hospitalization and up to 30 days post discharge.

the purpose of this study is to compare in a randomized, controlled, single-blinded, 1:1 fashion ufh versus bivalirudin in patients with stable angina pectoris or silent ischemia undergoing pci. secondary study endpoints will include: * major adverse cardiac events (mace) comprising of all cause mortality, myocardial infarction (mi), ischemia driven target vessel revascularization (tvr), and cerebral vascular accident (cva). * net adverse clinical events (nace) will be consistent of mace plus major bleeding as defined by the replce-2 criteria. * cardiac death in-hospital and up to 30 days post discharge. * mi in-hospital and up to 30 days post discharge. * cva in-hospital and up to 30 days post discharge. * incidence of all-cause mortality at 6 months and 1 year. * mace at 6 months and 1 year. * incidence of acute (0-24 hours post procedure) stent thrombosis rates. * incidence of sub-acute (24 hours - 30 days) stent thrombosis rates. * length of hospital stay (los) * economic analysis (total cost during hospitalization) and up to 30 days post discharge.

Eligibility criteria:
inclusion criteria: 1. the patient is male or female ≥ 18 years of age. 2. the patient presents with stable angina pectoris, or silent ischemia (positive stress test without chest pain). 3. the patient is scheduled for coronary angiography, with possible angioplasty. 4. the patient is able to tolerate dual anti-platelet therapy with aspirin and clopidogrel for a minimum of 30 days and is on those medications at the time of the pci (clopidogrel may be administered during pci or within 30 minutes post pci). 5. the patient is able and willing to conform to the requirements of the study and voluntarily signs an informed consent. 6. the patient does not present with any form of illness or condition that in the investigator's opinion would impair the results of the study. 7. women of child bearing potential must have a negative urine or serum pregnancy test prior to enrollment. exclusion criteria: 1. patients in cardiogenic shock. 2. patients with acute coronary syndrome, which includes unstable angina, non-st-elevation mi or stemi. 3. known history of heparin-induced thrombocytopenia. 4. contraindication to unfractionated heparin, bivalirudin, or any anticoagulant or antithrombotic pharmacological agent. 5. any significant medical condition, which in the investigator's opinion, may interfere with the patient's optimal participation in the study. 6. pregnant women or nursing mothers.

Keywords: coronary artery disease stable angina percutaneous coronary intervention
follow up study of patients undergoing total hip arthroplasty cerafit® grafted with poly sodium styrene sulfonate

Conditions: Hip Arthroplasty Replacement

Summary: the risk of infection after primary total hip arthroplasties (tha)is generally estimated to be less than 1% but remains a severe and costly complication, source of morbidity and even mortality. the "biofilm" forms very early after the bacterial contamination of the prosthesis and poses a number of clinical challenges due to his resistance to immune defence mechanisms and antibiotics. preventive strategies are needed. the poly sodium styrene sulfonate (pnass) is a bioactive polymer. in vitro and in vivo studies showed that poly sodium styrene sulfonate grafted on titane surfaces reduce significantly the bacterial adhesion. they also proved his biocompatibility and osseous-integration.


Eligibility criteria:
inclusion criteria: * age less than 75 years old * aetiologies for tha : primary osteoarthritis, inflammatory diseases,osteonecrosis exclusion criteria: * previous infectious hip arthritis * previous surgeries on the operated hip * revision of tha

Keywords: total hip arthroplasty hip osteoarthritis infection after total hip arthroplasty
prevention of rabies with four doses of rabies vaccine

Conditions: Rabies Human; Antibody

Summary: to evaluate the non inferiority of the immunogenicity of the test vaccine inoculated according to the four dose immunization program over the five dose immunization program and the batches consistency of immunogenicity according to five dose immunization procedures.

* in the population aged 10-60 years, evaluate the non inferiority of the immunogenicity of the test vaccine inoculated according to the four dose immunization program (0, 3, 7, 14/28 days) over the five dose immunization program (0, 3, 7, 14, 28 days)； * to evaluate the consistency of immunogenicity between batches of freeze-dried human rabies vaccine (vero cell) inoculated according to five dose immunization procedures (0, 3, 7, 14, 28 days).

Eligibility criteria:
inclusion criteria: * people aged 10-60； * body temperature on the day of enrollment\<37.3℃ (axillary temperature) exclusion criteria: * have a history of rabies vaccine immunization or use of rabies virus passive immunization agents； * people with congenital or acquired immunodeficiency or other autoimmune diseases； * female urine pregnancy test is positive, or during pregnancy and lactation, or she has a birth plan during the study period;
the effects of bifidobacterium breve bif195 for diarrhea-predominant irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to investigate if the probiotic bifidobacterium breve bif195 (bif195) will result in improvement in clinical outcome in patients with diarrhea-predominant irritable bowel syndrome (ibs).

ibs is the most frequently diagnosed gastrointestinal disease and also the most common cause of referrals to gastroenterology departments in denmark. the possibilities for treatment for ibs are limited. treatment strategies that involve the microbiota provide symptom relief in some ibs patients. several studies have demonstrated that the composition of the gut microbiota in ibs patients is different from healthy controls. probiotic interventions has shown promising results, but it currently remains unknown which probiotics are effective and which are not. a new probiotic bacterium, bifidobacterium breve bif195 (bif195) has been identified and has shown great effects on preventing enteropathy and ulcers on the gut mucosa in healthy volunteers given acetylsalicylic acid, and thereby bif195 has also shown a potential in reducing gut permeability defects. this bacterium has not yet been investigated in ibs patients.

Eligibility criteria:
inclusion criteria: * diagnosed with ibs-d defined as more than one-fourth (25%) of bowel movements with bristol stool scale types 6-7 and less than one-fourth (25%) with types 1-2 * fulfill rome iv diagnostic criteria for ibs * moderate to severe disease activity (ibs-sss ≥175) * able to read and speak danish * normal colonoscopy (performed within 1 year) if the patient had blood in stool exclusion criteria: * other chronic gastro intestinal diseases including lactose intolerance and coeliac disease * fecal calprotectin ≥50 mg/kg * fecal sample positive for enteropathogenic microorganisms * surgical interventions in the gi region (except for appendectomy, hernia repair, cholecystectomy and gynecological and urological procedures) * psychiatric disorder * abuse of alcohol or drugs * medications except birth control pills, hormone supplements, allergies/asthma agents, blood pressure and cholesterol-lowering agents, proton pump inhibitors and non-prescription medicines; abnormal colonoscopy findings * pregnancy, planned pregnancy or breastfeeding females * ingestion of probiotics or antibiotics \<4 weeks before the inclusion * abnormal screening biochemistry

Keywords: probiotics
a study of cesium-131 brachytherapy following sub-lobar resection for early stage non small cell lung cancer

Conditions: NSCLC; Non Small Cell Lung Cancer

Summary: for patients diagnosed with early (stage i) non-small cell lung cancer, a lobe of lung is usually removed at surgery to treat the cancer. for some patients, the removal of a lobe of lung may leave too little lung behind for easy breathing. for some of these patients, it may be possible to perform a smaller-scale surgery ("sub-lobar resection") and place a radioactive implant behind to prevent the cancer from growing back. this study will see how these patients do in terms of controlling their disease treated with a radioactive implant called cesium-131.


Eligibility criteria:
inclusion criteria: 1. patients must have suspicious lung nodule for clinical stage i/recurrent non-small cell lung cancer 2. mass tumor size \< 7 cm 3. patient must have a ct scan of the chest with upper abdomen within 90 days prior to date of pre-registration. 4. patient must have ecog/zubrod performance status 0,1, or 2. exclusion criteria: 1. patient has already received high dose radiation to the area 2. cancerous nodule is very close to the esophagus or spinal cord, thereby increasing the risk of radiation treatment 3. pregnancy or unwillingness to practice a form of birth control (i.e. abstinence, oral contraceptives, etc.)

Keywords: brachytherapy lung brachytherapy nsclc sub-lobar resection
external drainage versus internal drainage of pancreatic duct with a stent after pancreaticoduodenectomy (edidpd)

Conditions: Postoperative Fistula; Complications of Surgical and Medical Care: General Terms

Summary: postoperative pancreatic fistula (popf) and other surgical complications are common after pancreatoduodenectomy (pd) and popf is a major complication. the drainage of pancreatic duct is important and a stent is usually placed in the operation, but it is still controversial whether the stent drainage is internal or external.

the current study is to compare the rate of postoperative pancreatic fistula(popf) and other surgical complications after pancreatoduodenectomy (pd).

Eligibility criteria:
inclusion criteria: * age more than 18 years. * received pancreatoduodenectomy. * informed consent has been signed. exclusion criteria: * age less than 18 years * emergency surgery * past history of pancreatic surgery.

Keywords: postoperative pancreatic fistula(popf); postpancreatectomy hemorrhage(pph); delayed gastric emptying (dge); bile leakage after pancreatic surgery; anastomotic leakage
photodynamic therapy (pdt) for lower urinary tract symptoms (plus)

Conditions: Prostatic Hyperplasia

Summary: the purpose of this study is to determine if transurethral photodynamic therapy with lemuteporfin has a therapeutic effect on lower urinary tract symptoms due to an enlarged prostate. photodynamic therapy (known as "pdt") is a treatment that uses light to make a drug work. this means the drug is "light-activated". light-activated drugs do not work until a certain color of light shines on the drug. when the drug and the light combine, they react together to destroy tissue. this study is investigating pdt with lemuteporfin as a possible treatment for an enlarged prostate. pdt with lemuteporfin may destroy overgrown prostate tissue and help urinary symptoms go back to normal.

this is a multi-center, randomized, sham-controlled, double-blind, dose-finding study in parallel groups of subjects with lower urinary tract symptoms (luts) due to benign prostatic hyperplasia (bph). all subjects will receive a fixed dose of lemuteporfin injected transurethrally into the prostate followed by transurethral application of either one of three active light doses or a sham light dose. subjects will be followed for safety and efficacy for a minimum of three months to a maximum of 12 months. the primary study endpoint will be the change from baseline in aua si score at three months.

Eligibility criteria:
inclusion criteria: * men 21 years of age and older. * subjects with luts due to bph with aua si scores of 13 and over and qmax between 5 and 15 ml/sec. * subjects with urethral treatment length of at least 25 mm. exclusion criteria: * subjects who have had previous minimally invasive or surgical treatment for bph. * subjects who have unsuitable prostate dimensions.

Keywords: benign prostatic hyperplasia (bph) photodynamic therapy (pdt) lower urinary tract symptoms (luts)
comparison between two different parameters of argon plasma coagulation in the treatment of chronic radiation proctitis: historical control trial.

Conditions: Radiation Injuries; Telangiectasis; Rectal Bleeding

Summary: there is a wide variability of options for treatment of chronic radiation proctitis. however, studies are still limited, usually case reports from a single center and few are comparative studies between methods. therefore, the choice of treatment is determined by availability and local expertise for each method. the variability of treatment options range from anti-inflammatory medical treatment, sucralfate, short chain fatty acids, antioxidants and hyperbaric oxygen to such endoscopic and surgical treatments. surgery is usually the last therapeutic option due to the high morbidity and mortalityassociated. various endoscopic treatment modalities have been reported. formalin topic is effective in up to 48% of patients with chronic radiation proctitis. the endoscopic treatment with argon plasma (apc) is low cost, easy to apply and transportation, safe and effective in the treatment of rectal bleeding in patients with chronic radiation proctitis. currently, the apc is the preferred endoscopic modality. most studies on the use of apc in radiation proctitis showed benefit. the apc controls the mild to moderate rectal bleeding in 80% to 90% of cases and improves symptoms of urgency, diarrhea and tenesmus in 60% to 75% of cases.

apc is usually applied with a power of 40-60w and 1.2-2.5 l/min of gas flow by using a electrosugical generator coupled with an argon delivery unit. however, high gas flow have been associated to high rates of complication such as rectal stenosis and deep rectal ulcer. in this context, the present study aims to compare the effectiveness and safety between two different paramenters of argon plasma coagulation (40-50w and 2.0 l/min of gas flow vs 40w and 1.2 l/min of gas flow) in the treatment of patients with symptomatic chronic radiation proctitis.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * endoscopic diagnosis of chronic radiation proctitis * previous pelvic radiotherapy * presence of colonic or rectal telangiectasias * patients must have the ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * other causes of rectal bleeding besides chronic radiation proctitis diagnosed by complete colonoscopy , such as colorectal cancer , inflammatory bowel disease and polyps larger than 1 cm * use of oral anticoagulants

Keywords: chronic radiation proctitis argon plasma coagulation rectal bleeding
evaluation of cell-mediated immune response by quantiferon monitor® assay in kidney transplant recipients

Conditions: Kidney Transplant Infection; Kidney Transplant Rejection

Summary: all kidney transplant recipients require immunosuppression, the net level of which is difficult to assess. current practice in assessing immune reactivity is to monitor levels of some immunosuppressive drugs. quantiferon monitor® (qfm) is an in vitro diagnostic test that detects interferon-γ (ifn-γ) release in peripheral blood. its clinical utility in assessment of the net state of immunosuppression in kidney transplant recipients has not been well studied. the aim of our study is to evaluate the discriminating value of qfm testing results for infection and rejection in a single-centre cohort of kidney transplant recipients.


Eligibility criteria:
inclusion criteria: * kidney/liver kidney/simultaneous pancreas and kidney transplantation exclusion criteria: * none

Keywords: kidney transplantation rejection infection immunosuppression
the anatomical localization of the inferior mesenteric artery in relation to the left colonic artery

Conditions: Rectal Cancer

Summary: 1. to observe and measure the distance between the origin of lca (left colonic artery，lca) and ima (inferior mesenteric artery，ima) root and the distance between ima and imv (inferior mesenteric vein，imv) at the origin of lca in rectal cancer patients. statistical analysis of intraoperative measured data, on the basis of the original anatomical relationship, to achieve anatomical localization of quantitative and accurate, for the preservation of lca laparoscopic radical resection of rectal cancer to provide a strong anatomical basis. 2. the operation time, 253 lymph node dissection time, intraoperative blood loss, postoperative anal exhaust time, postoperative feeding time, postoperative hospital stay, postoperative ischemic colitis rate and postoperative anastomotic leakage rate of patients with laparoscopic radical resection of rectal cancer with preservation of lca were recorded. the surgical efficacy and clinical significance of laparoscopic radical resection of rectal cancer with preservation of lca were evaluated.


Eligibility criteria:
inclusion criteria: * pathological diagnosis of rectal cancer (t2-4a, n- / +, m0) ; laparoscopic radical resection of rectal cancer and preservation of lca patients and their families agree to participate in the clinical study exclusion criteria: * those who had a history of lower abdominal surgery and could not undergo laparoscopic surgery lca vascular absence was found during operation combined with other malignant tumors pregnant or lactating patients combined with severe mental illness severe diseases of the blood system, coagulation dysfunction ; preoperative assessment of heart, lung and brain function, unable to tolerate surgery.
preventive colostomy vs ileostomy in low anterior rectal resection

Conditions: Rectal Cancer

Summary: the type of preventive intestinal stoma (colostomy/ileostomy) after low anterior rectal resection rectum is still a debate. this study purpose is to demonstrate that preventive loop ileostomy is characterized by a higher readmission rate caused by dehydration, in comparison with the loop colostomy.

modern surgery for the rectal cancer is featured by sphincter-preserving operations. it is proved that colorectal anastomosis leakage is severe and, in some cases, lethal complication that reduces quality of life of patients and increases the risk of disease reccurence. the presence of preventive stoma is an effective way to avoid this complication that is why it's included to treatment protocols for the middle and low ampullary rectal cancers is undisputed by the most of surgeons. however, the type of preventive stoma is under discussion yet and remains to be an urgent issue. the majority of large meta-analyzes demonstrates that preventive ileostomy is used more often for the protection of low colorectal anastomoses. in the western countries the preferred method is double barreled ileostomy due to more rapid formation and closure, as well as due to lower rate of stoma-related morbidity. in russia and cis countries the double-barreled transverse colostomy is a preferred method of defuction of low colorectal anastomosis due to lower rate of electrolytic disorders and related hospital admissions, along with series of unproven advantages. presented study will allow to reveal the early and late postoperative morbidity rate and the related hospital re-admissions in real-life clinical practice of russia from the standpoints of evidence- based medicine, to define indications and contraindications for each type of "low" colorectal anastomosis protection with the least risk for the patient.

Eligibility criteria:
inclusion criteria: * mid- and low rectal cancer * age ≧ 18 * tme * asa ≦ 3 * no previous stoma formation * informed consent for participation exclusion criteria: * patients lost during the follow-up * refusal of the patient from further participation in the study * inability of stoma formation

Keywords: colostomy ileostomy rectal cancer low anterior resection
vitamin d supplementation and effects on mood in emergency medicine residents

Conditions: Seasonal Mood Disorder

Summary: seasonal mood changes, and even feelings of depression, appear to have an association with decreased amounts of vitamin d in people living in geographic areas where exposure to sunlight during the winter months is relatively low. in this study, pgy-2 and pgy-3 emergency medicine residents at lakeland health will fill out phq-9 surveys for a total of 6 months (october-march), filled out at the end of each month. this is the time of year in southwest michigan where exposure to direct sunlight is the lowest. the results of the individual surveys will be trended for the entire six months to see if individuals responds more positively after vitamin d supplementation is initiated between months 3 and 4. vitamin d supplementation will be 5000 units daily for the months of january-march.


Eligibility criteria:
inclusion criteria: * pgy-2 and pgy-3 emergency medicine residents at lakeland health exclusion criteria: * nonresidents and pgy-1 and pgy-4 emergency medicine residents at lakeland health