Kornimate/medical-research-clean huggingface dataset:
evaluation of efficacy of liquid platelet rich fibrin in temporomandibular joint disorders

Conditions: Temporomandibular Joint Disorders

Summary: this randomized clinical trial aims to evaluate the efficacy of liquid platelet-rich fibrin administration at different wilkes stages.

thirty six patients with unilateral painful internal derangement (id) (wilkes' 3-4-5) were included. patients were divided into 2 groups. in group 1 were treated with only artrosythesis. in group 2 were treated with artrosythesis and liquid platelet rich fibrin. in group 2, patients were injected with 1.5-2cc of liquid platelet-rich fibrin within the superior joint space at operation day. pain and subjective dysfunction were recorded using a visual analog scale and helkimo index at operation day and tenth day, one month later and 3 months later.

Eligibility criteria:
inclusion criteria: * unilateral internal temporomandibular disorder * localized temporomandibular joint pain * scoring 3 and above in wilke's classification. exclusion criteria: * autoimmune diseases * significant mechanical obstruction that prevents mouth opening * acute capsulitis, * benign or malignant temporomandibular joint lesions * neurological disorders, * blood diseases and coagulation disorders * patients with a history of allergies or anaphylactic shock.

Keywords: liquid platelet rich fibrin temporomandibular joint disorders wilkes classification
the evaluation of care demand and intervention models for individuals with asd in taiwan

Conditions: Autism Spectrum Disorder

Summary: the prevalence of autism in taiwan has been significantly increasing over this decade. though early intervention program and special and resource education have been applied in helping individuals with autism in taiwan, studies regarding autism in this country so far focus mostly on the prevalence and demographics in restricted populations, diagnostic category, single case observation, and clinical research. although the data of needs of care and intervention models in autism emerges in western countries, there is a lack of such data in taiwan. due to the high prevalence, long-term impairing and lack of effective prevention, detection, and treatment for autism, tremendous of the resource is needed to be given to individuals with autism. however, the investigators do not know the gap between the need and provided care in currently. this study aims to understand the current state of needs of care and intervention in autism from different stakeholders to inform and improve the health care policies for autism and to establish a holistic care/intervention model for autism in taiwan.

this study will enroll individuals with autism and their family members from autism-related medical, nongovernmental organizations, and general educational settings, where from elementary schools to colleges, in taiwan. for patients and their family, the investigators will enroll total 2000 adult individuals with autism and their family members for the questionnaire survey. the needs of assessment and care, and intervention models in autism will be examined using the chinese version of camberwell assessment of need, autistic traits assessment, emotional difficulty questionnaire, quality of life and self-administered questionnaire with different versions for stakeholders. the guides for parents and clinicians on autism will be discussed with the patient and family representatives and developed by different autism stakeholders, experts, and scholars based on regular research meetings. quantitative analyses will be conducted to understand the need and difficulty of care and interventions in autism across different developmental stage. the investigators anticipate to find differences in care needs by personal characteristics. the survey of the care needs of autism will provide family members, medical and nursing personnel, and related caregivers more information about understanding their care requirements. these results will help the government for the formulation of policies related to early treatment and long-term care. finally, the guides for parents and clinician on autism would be suggested references.

Eligibility criteria:
inclusion criteria: * individuals with autism from autism-related medical, nongovernmental organizations, and general educational settings, where from elementary schools to colleges, in taiwan. exclusion criteria: * family members of autism cannot complete questionnaire survey will be excluded from the study.
training levels comparison trial

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia

Summary: to determine the effects of high or low intensity long-term exercise conditioning in patients with coronary artery disease.

background: a vast amount of literature exists on the improvements in work capacity, reduction of risk factors, and an increased feeling of well-being among coronary heart disease patients after physical training programs. previous observations of short-term training programs which resulted in an increase in physical working capacity have not usually shown a cardiac change. the national exercise and heart disease project did not show such changes, but the exercise level may have been inadequate. several other studies suggested that more prolonged and intense training could result in improved cardiac function. design narrative: patients were randomized to high intensity or low intensity long-term exercise groups. compliance was strengthened by randomizing following a sequence of eligibility visits and after a test period of subject reaction to an exercise program. the primary endpoint was change in exercise ejection fraction at one year. secondary endpoints included changes in lipid levels, body composition, blood pressure and heart rate measurements, glucose tolerance, quality of life measures, compliance, and progression of disease. patients were classified into one of four strata based on the documented history of myocardial infarction and resting left ventricular ejection fraction. within each stratum, patients were assigned in equal numbers to the two intensity levels of exercise intervention. all exercise prescriptions were based on exercise testing of patients maintained on their usual medical regimen including drugs. patients underwent standardized multistage treadmill exercise testing monitored by doppler echocardiogram at baseline, just prior to randomization and at the three month, six month, one year and two year visits. patients participated in the structured group exercise sessions three days per week. each exercise session was preceded by and ended with a five to fifteen minute warm-up and cool-down session. each patient was given an exercise prescription that included a 30 minute period of walking or of walking and jogging sequences and 15 minutes of arm-leg bicycle ergometer exercise. recruitment started in may 1987. the last patient was enrolled in march 1990.

Eligibility criteria:
men, ages 30 to 67, with documented coronary heart disease.
clinical performance of a flowable bulk fill composite versus a highly viscous glass-ionomer cement in primary molars

Conditions: Management of Dental Caries of Primary Molars

Summary: the study was conducted to compare and evaluate the clinical performance of equia forte and sdr® flow+ in class ii cavities in primary molar

initial intra-oral periapical bitewing radiographs of the teeth to be treated were taken before the procedure. after obtaining partial isolation using cotton rolls and saliva ejector, caries excavation and removal of undermined enamel will be done using high-speed diamond burs with water cooling and hand instruments. after finishing the cavity, a matrix band will be placed with the interproximal wedge. the prepared cavities will be restored using equia forte or flowable bulk-fill composite resin according to the manufacturer's instructions.

Eligibility criteria:
inclusion criteria: 1. 4 to 8 years old medically free children. 2. cooperative children are classified as class 3 or 4 based on frankel et al. classification. 3. children who had at least one active dentinal carious lesion on the proximal surface of primary molars exclusion criteria: 1. refusal of the parents to sign the informed consent 2. presence of deep bite or any pictures of malocclusion and parafunctional habits.

Keywords: bulk-fill flowable composite , high viscous gic ,
detect-register documentation and evaluation of a copd combination therapy

Conditions: Chronic Obstructive Pulmonary Disease

Summary: prospective, multi-centre, non-interventional study to collect findings about the effects of laba/lama (long acting beta2-agonists / long acting muscarinic antagonists) combination preparations on copd (chronic obstructive pulmonary disease) symptoms and quality of life under real conditions and to find out what types of patients are selected for this therapy by physicians.

retrospective aspect of documentation: for patients who have already been changed over to a fixed-dose combination, lung function parameters and cat (copd assessment test™) score from the time prior to the changeover will be documented.

Eligibility criteria:
inclusion criteria: * female/male of at least 40 years of age * patient diagnosed with copd * patient was changed over within the last 3 months to a fixed-dose combination (fdc) (aclidinium/formeterol, glycopyrronium/indacaterol or umeclidinium/vilanterol), or there is already the intent to change the patient over to a fixed-dose combination (aclidinium/formeterol, glycopyrronium/indacaterol or umeclidinium/vilanterol). * lung function parameters and cat score from the time prior to the changeover to an fdc are on record (within the last 6 months in the case of patients who have already been changed over) or are determined at the 1st visit (in the case of patients who have not yet been changed over but for whom such a changeover is intended). * signed declaration of consent exclusion criteria: * the prescribing information for the fixed-dose combinations (duaklir® genuair®, ulibtro® breezhaler® or anoro®) list contraindications for the patient. * patient is pregnant, plans to become pregnant, or is nursing during the therapy period. * patient suffers from hypersensitivity to one of the active ingredients of the fixed-dose combinations. * patient is participating in a clinical trial.

Keywords: chronic obstructive pulmonary disease fixed-dose combination lama/laba (long acting beta2-agonists / long acting muscarinic antagonists) inhaler aclidinium/formoterol glycopyrronium/indacaterol umeclidinium/vilanterol
open versus arthroscopic assisted treatment of acute acromioclavicular joint disruption using suture button device

Conditions: Acromioclavicular Joint Dislocation

Summary: compare the clinical and radiological outcome between the arthroscopic and open surgical repair using suture button device method in cases with acute ac joint disruption

acromioclavicular (ac) joint dislocation is a common shoulder injury, especially among athletes and has an estimated incidence of 17% of all shoulder injuries and30%-50% of athletic shoulder injuries ,in most cases, these are caused by a direct fall on the ipsilateral shoulder tip. the indirect mechanism of injury with an extended arm is rare, the rockwood classification system is currently used and based on the degree and direction of the disrupted anatomy of the ac joint. despite the high prevalence of this injury, there is no consensus about its optimal treatment. a variety of surgical procedures are described in the literature, such as an augmented suture with absorbable materials, stabilization with kirschner (k)-wires in combination with or without additional wire loops, hook plates, or the bosworth screw, but none can be considered the gold standard of operative ac joint stabilization, another treatment option was offered by the tight rope system, this technique was developed as a minimally invasive procedure in the management of ac dislocations. because of its minimally invasive approach, it reduces soft tissue damage and yields better cosmetic results.9 also, there is no need for reoperation to remove the hardware that might screws, or plates. moreover, the complications of hardware failure, like breakage, dislocations, or bone fractures, are minimized

Eligibility criteria:
inclusion criteria: * age of 16 to 60 years * definite radiographic diagnosis of isolated rockwood type iiib(unstable), iv and type v acromioclavicular joint dislocation * time from injury to operation \< 3 weeks * patient with complete at least 12-month follow-up assessments exclusion criteria: * . age outside the range * open injury, old injury (≥ 3 weeks since injury) * injury caused by other diseases (tendinitis, metabolic, et al.), concurrent shoulder osteoarthritis, arthropathy or any fracture * any previous operation of the injured limb * incomplete data or follow-up \< 12 months
translation and validation of pelvic girdle questionnaire in urdu language

Conditions: Pelvic Girdle Pain

Summary: urdu version of pelvic girdle questionnaire was drafted, tested for its reliability and validity on patients with pelvic girdle pain. urdu version was linguistically acceptable and accurate for pregnant and post partum females with pelvic girdle pain. the result seems comparable to all the other versions and especially with original norwegian version. this instrument is understandable and easy to find disability during pregnancy and post partum duration. it showed a good content, construct and convergent validity also present high internal consistency and test retest reliability.

the pelvic girdle questionnaire is the only specific instrument designed to evaluate pain and activity limitations in pregnant or postpartum women with pelvic girdle pain. this study aimed to translate the pelvic girdle questionnaire in urdu language for pakistani female patients and to verify the validation of the psychometric items of the pelvic girdle questionnaire in population of pakistan. the purpose of this study was to translate the pelvic girdle questionnaire into urdu and find out cross-culture validity and reliability of urdu pelvic girdle questionnaire among pregnant and postpartum females. a cultural adaptation and translation study was performing according to international guidelines. study was conducted at different hospital settings. pre test was conducted among 16 females during pregnancy \& post-partum. key words: disability evaluation, female, urdu, pelvic girdle pain and physiopathology, pregnancy, surveys and questionnaires, translation.

Eligibility criteria:
inclusion criteria: * age 18-50 years * only females * able to read urdu language * pregnant women (gestational week 30-38) * postpartum women (given birth less than one year earlier) exclusion criteria: * any neurological diseases (reflex changes \& loss of sensation) * unstable medical conditions leading to fatigue * those that have prolapse or severe urinary disease * previous surgery on pelvis, lower limb or spine * cannot understand urdu * difficulty in understanding the pelvic girdle questionnaire
the general use of robots in stroke recovery

Conditions: Stroke

Summary: the purpose of this study is to determine if tailoring multiple sessions of upper extremity robotic therapy to focus on a particular aspect of movement (e.g smoothness vs. aiming; active range of motion vs. functional practice)can optimize therapeutic results and lead to greater functional returns in arm mobility after stroke.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * first single focal unilateral lesion with diagnosis verified by brain imaging, which occurred at least 6 months prior * cognitive function sufficient enough to understand experiments and follow instructions * fugl meyer assessment at admission of 7 to 38 out of 66 (neither hemiplegic nor fully recovered motor function in the muscles of the shoulder, elbow, and wrist) exclusion criteria: * prior experience with robotic arm therapy * fixed contraction of the affected limb * complete flaccid paralysis of the affected limb

Keywords: stroke cerebrovascular accident cerebral stroke cva robotic therapy upper extremity recovery kinematic training
a study of rivaroxaban for early discharge of low risk pulmonary embolism from the emergency department

Conditions: Pulmonary Embolism

Summary: the purpose of the study is to evaluate that low risk pulmonary embolism (pe) participants who are discharged from the emergency department (ed) to the home environment and treated with rivaroxaban as outpatients have fewer total days in the hospital for bleeding and/or venous thromboembolism (vte) events through day 30 compared to participants who are treated with initial hospitalization and standard-of-care.

this is a randomized (study medication is assigned by chance), open-label (all people know the identity of the intervention), parallel-group, multicenter (study conducted at multiple sites) study to evaluate that low risk pe participants who are discharged from the ed and treated with rivaroxaban compared to participants who are treated with initial hospitalization and standard-of-care. the study consists of a screening and randomization period, followed by a 90-day open-label treatment period, and an end of study/early withdrawal (eos) visit. the duration of study participation for each participant is approximately 3 months. the participants will be randomized in a 1:1 ratio to one of two treatments. safety will be monitored during the study.

Eligibility criteria:
inclusion criteria: * have confirmed acute symptomatic pulmonary embolism (pe) with or without symptomatic deep vein thrombosis (dvt) * a pe participant diagnosed in the emergency department (ed) who is deemed to be at low risk of clinical deterioration as determined by the hestia criteria * have no contraindications to and be able to complete randomized treatment and all study assessments * have a life expectancy of at least 6 months * must be willing and able to adhere to the prohibitions and restrictions specified in this protocol exclusion criteria: * having received any combined p-gp (p-glycoprotein) and strong cyp3a4 (cytochrome p450) inhibitors (such as but not limited to ketoconazole, telithromycin or protease inhibitors) use within 4 days before randomization, or planned use during the study. itraconazole use within 7 days before randomization or planned use during the study * having received any combined p-gp and strong cyp3a4 inducers (such as but not limited to rifampin/rifampicin, rifabutin, rifapentine, phenytoin, phenobarbital, carbamazepine, or st. john's wort) use within 2 weeks before randomization or planned use during the study * who has contraindications to the use of any anticoagulant therapy (example, bleeding diathesis, history of gastrointestinal bleeding within 1 year or coagulopathy documented at screening) * who has known allergies, hypersensitivity, or intolerance to rivaroxaban or its excipients * woman who is pregnant, or breast-feeding, or planning to become pregnant

Keywords: rivaroxaban jnj39039039 pulmonary embolism
buspirone for opioid tapering

Conditions: Opioid-Related Disorders; Dependency (Psychology); Pain, Chronic; Opiate Withdrawal Syndrome

Summary: this is a pilot study to collect preliminary data to support a grant application. the goal of the study is to evaluate whether the food and drug administration (fda)-approved and generically-available medication buspirone reduces symptoms of opioid withdrawal among patients undergoing a clinically-indicated and supervised taper from their opioid pain medications. this is premised on strong preclinical scientific support but has not yet be well-examined in humans.

buspirone (buspar) has shown initial efficacy in reducing symptoms of opioid withdrawal in animal studies and in human patients undergoing a methadone taper. buspirone may have pharmacologic activity in specific neurotransmitter systems that preclinical evidence suggests may be implicated in the manifestation of opioid withdrawal symptoms. administration of buspirone during an opioid taper may improve outcomes relative to placebo. the goal of this study is to collect preliminary feasibility and efficacy data from a sample of patients undergoing clinically-indicated opioid tapering. participant enrollment will occur at the beginning of their residential stay on the pain treatment unit at johns hopkins hospital. participants will be randomly assigned to receive buspirone (15 milligrams, three times daily, for daily dose of 45 milligrams) or placebo. daily assessments for withdrawal and requests for additional symptomatic medications will be evaluated as evidence of initial efficacy. feasibility measures include willingness to participate and study retention.

Eligibility criteria:
inclusion criteria: * be at least 18 years old * be undergoing taper of prescribed opioid pain medications at the study site exclusion criteria: * being pregnant or breastfeeding * past 7-day use of grapefruit juice or other strong cytochrome (cyp) p450 inhibitors or inducers * have medical or psychiatric condition that is contraindicated with buspirone administration * current suicidality as assessed by clinic staff or the columbia suicide severity rating scale

Keywords: buspirone
protocol to distinguish tumor recurrence from treatment-related necrosis in patients with high grade gliomas

Conditions: Recurrent High Grade Gliomas

Summary: brain imaging tests are routinely used to detect the presence of a brain tumor or to evaluate the response to treatment. sometimes the images obtained are not specific and the only way to establish a diagnosis is by obtaining a tissue sample. the hypotheses of the study is to determine if multimodal mr technique will provide tissue signatures that differentiate between tumor progression and treatment related necrosis in high grade glioma patients.


Eligibility criteria:
inclusion criteria: * histologically proven high grae glioma with central pathology review at dhmc * age 18 equal to or greater than 18 years * karnofsky performance greater or equal to 60% * patients must have received radiation therapy and chemotherapy but should not have received any anti-angiogenesis therapy. exclusion criteria: * any patient who requires urgent surgical resection of mri abnormality would not be eligible * pregnant women are not eligible