Kornimate/medical-research-clean huggingface dataset:
validation of an ecological organization and problem solving test (tem-pro) in vocational rehabilitation

Conditions: TBI (Traumatic Brain Injury)

Summary: standard neuropsychological evaluations after severe tbi (traumatic brain injury) often minimizes the executive deficits, these latter are known to seriously impair return to work. therefore, we developed an ecological organization and problem-solving test in a vocational setting called the tem-pro. the test consists of 4 activities of variable complexity, collection and redaction of information and demands to follow well defined rules.

while there may be many reasons for obtaining neuropsychological assessement after tbi, predication of the real world functioning is generally the final goal. among the cognitive deficits, the dysexecutive syndrome is certainly the most disabling in impeding to return to work. the classical neuropsychological tests often fail to asses theses deficits adequately. several more ecological tests have been previously developed. based on the multiple errands test and the six elements test, we built up first an ecological test over 60 minutes for activities of the daily living (test des errances multiples, " tem, version crr "). used regularly in the clinical setting, it was able to evaluate the functional aptitudes of the patients and was useful to complete the classical neuropsychological tests. however test duration is too short and activities are far away from real work scenarios to test working aptitudes. therefore we developed a new executive-ecological test in a vocational setting (tem-pro). the adaptation of the original test in a vocational setting induces the addition of 4 activities of variable complexity, research and redaction of information and demands to follow well defined rules. skills that are solicited are planning, selective and sustained attention, prospective memory, organization, problems solving and behavior adaption over a long period of time. based on a pilot study with patients without neurological deficit we assessed that our test displayed good sensitivity without ceiling effect. it allowed a quantitative and differentiated evaluation, a classification of various error types (interpretation and judgment failure, rule breaks, task failures and inefficiencies) and provided a qualitative behavioral analysis.

Eligibility criteria:
inclusion criteria: french speaking patients, older than 18 years, able to understand and sign the study informed consent, able to answer questionnaires used in the study, suffering from moderate to severe tbi, without invalidate psychiatric comorbidities, without severe memory impairment, capable to participate for 4h in a vocational activity, planning to return to work. patients still receiving compensation and patients returned to work will be included exclusion criteria: alcohol or drug abuse, severe physical disability interfering with the test (modified ranking score \>1), under legal custody.

Keywords: multiple errands tests
the t1d exchange registry

Conditions: Diabetes Mellitus, Type 1; Diabetes; Type 1 Diabetes; Diabetes Mellitus

Summary: the t1d exchange registry is a research study, conducted over time, for individuals with type 1 diabetes and their supporters. participants volunteer to provide their data for research (for example, by answering questions in annual surveys). once enrolled, registry participants have the opportunity to sign up for other studies on various topics related to type 1 diabetes. to participate, you will be asked to: * read and sign an online informed consent form * take a survey describing specific demographic and type 1 diabetes management information * update your information annually * periodically opt in for additional research opportunities (if you choose), i.e. taking new surveys or uploading health device data


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 1 diabetes. * individuals younger than 18 years of age must have parent/guardian consent. * must be able to read and understand english. * currently living in the united states exclusion criteria: * does not use insulin and has not had a pancreatic or islet cell transplant. * cannot fully read and understand english. * does not currently live in the united states.

Keywords: insulin t1d dm diabetes type 1 glucagon
echocardiographic analysis by artificial intelligence in hypertension

Conditions: Arterial Hypertension

Summary: the objective of this study is to develop artificial intelligence (ai) tools to characterize cardiac remodelling in arterial hypertension through the analysis of routine imaging data (echocardiography) coupled with patient data. more precisely, this study will make it possible (i) to represent in a relevant way the spectrum of the cardiac repercussions of a population affected by hypertension to better characterize the progress of the pathology, in particular vis-à-vis the more ambiguous subjects to be characterized ("grey" area); (ii) to develop tools for the automatic quantification of cardiac function (segmentation and robust monitoring of the myocardium during the cardiac cycle, for the dynamic analysis of the shape and global deformation of the heart) and therefore to extract descriptors richer in cardiac function than those currently used in clinical routine.


Eligibility criteria:
inclusion criteria patients who underwent a comprehensive blood pressure assessment during hospitalization in the cardiologic federation at croix rousse hospital and lyon sud hospital between january 2018 and december 2021. exclusion criteria patients who are minors. patients under curatorship or guardianship.

Keywords: hypertension htn arterial hypertension artificial intelligence ai cardiac remodelling left ventricular hypertrophy
complicated appendicitis in covid-19 era

Conditions: Covid19; Complicated Appendicitis

Summary: background the impact of the coronavirus disease 2019 (covid-19) pandemic on medical services is overwhelming due to limited medical resources. during its initial surge in 2020, taiwan's government rapidly established diverse public actions, which helped maintain the medical supply without travel restrictions. however, whether the fear of being infected with covid-19 interfered with health-seeking behavior (hsb) remains unclear. therefore, this study aimed to elucidate whether acute complicated appendicitis (aca) rates in adults were affected by the covid-19 pandemic. methods a retrospective analysis of acute appendicitis in adults was performed between january 1 and june 30, 2020 (covid-19 period). the control period was collected from the first two quarters for the preceding 3 years. outcome measures were aca and length of hospital stays.


Eligibility criteria:
inclusion criteria: * acute appendicitis exclusion criteria: * no

Keywords: health-seeking behavior covid-19 appendicitis
open-label safety study of telaprevir and sofosbuvir in chronic hepatitis c genotype 1

Conditions: Hepatitis C, Chronic

Summary: this is an open-label, multi center study of treatment-naive non-cirrhotic subjects with genotype 1 chronic hepatitis c virus. all subjects will receive telaprevir (tvr) in combination with sofosbuvir (sof) for 12 weeks.

starting on day 1 and for up to 12 weeks, you will receive telaprevir (tvr) and sofosbuvir (sof). you will take one (1) 400 mg tablet of sof and 3 tablets (1125 mg each) of tvr. you should take these together by mouth every morning. you will take another 3 tablets (1125 mg each) of tvr by mouth 12 hours after you take your morning dose.

Eligibility criteria:
inclusion criteria: * willing and able to provide informed consent * bmi (body mass index) ≥ 18 kg/m2 * hcv rna quantifiable at screening and \>1,000 iu/ml * hcv treatment naïve * hcv genotype 1 * 7. confirmation of chronic hcv infection documented by either: a positive anti-hcv antibody test or positive hcv rna or positive hcv genotyping test at least 6 months prior to the baseline/day 1 visit, or a liver biopsy performed prior to the baseline/day 1 visit with evidence of chronic hcv infection exclusion criteria: * current or prior history of any of the following: clinically-significant illness cirrhosis 2. screening ecg with clinically significant abnormalities 1. alt \> 10 x the upper limit of normal (uln) 2. ast \> 10 x uln 3. direct bilirubin \> 1.5 x uln 4. platelets \< 150,000/μl 5. hba1c \> 7.5% 6. creatinine clearance (clcr) \< 60 ml /min, as calculated by the cockcroft-gault equation 7. hemoglobin \< 11 g/dl for female subjects; \< 12 g/dl for male subjects. 8. albumin \< 3.1 g/dl 9. inr \> 1.5 x uln unless subject has known hemophilia or is stable on an anticoagulant regimen affecting inr 4. prior exposure to any approved or experimental hcv-specific direct-acting 5. pregnant or nursing female or male with pregnant female partner. 6. chronic liver disease of a non-hcv etiology (e.g., hemochromatosis, wilson's disease, alfa-1 antitrypsin deficiency, cholangitis). 7. infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv).

Keywords: hcv genotype 1 hepatitis c virus genotype 1 hcv tvr
cue-based vs. clinician-driven feeding in very low birthweight infants

Conditions: Infant, Very Low Birth Weight; Infant Development; Feeding Patterns

Summary: in this parallel-group randomized controlled trial, very low birthweight infants will be randomly assigned in a 1:1 ratio to either cue-based (intervention group) or clinician-driven feeding (control group). for infants in the intervention group, speech therapists and nurses will use their cue-based assessment training to aid in clinical management of oral feeding. for infants in the control group, clinicians caring for these infants will define the feeding plan based on their daily assessment.


Eligibility criteria:
inclusion criteria: * birthweight \< 1500 grams * gestational age between 28 and 31 weeks of gestation * full enteral feeding established before 32 weeks of postmenstrual age (pma) * oral feeding initiated before 33 weeks pma. exclusion criteria: * major congenital/chromosomal anomalies, * patent ductus arteriosus causing significant cardiovascular symptoms * history of necrotizing enterocolitis stage 2 or greater
expectation of driving performance in young adults with adhd assessed by driving simulator and seat pressure mapping

Conditions: Attention Deficit Hyperactivity Disorder

Summary: adolescents suffering of adhd may have impaired driving performance. the investigators would like to check the differences in driving performance in young adults(aged: 15-18 years) with adhd by driving simulator and seat pressure mapping with and without methylphenidate medication.

adolescents with adhd who are treated with one of the methylphenidate medication that is in use in israel(ritalin,ritalin sr,concerta,ritalin la)will be tested by driving simulator and seat pressure mapping by 2 stages: 1.when they are taking the medication that they are taking every day to control adhd and: 2. without medication ( after 4 day washout period).

Eligibility criteria:
inclusion criteria: * age 15-18 years suffering from adhd treated by methylphenidate before receiving driving license exclusion criteria: * any other neurological or psychiatric problem under treatment or investment adolescents who have driving license

Keywords: methylphenidate adhd driving simulator pressure adolescent
external pancreatic duct stent after pancreaticoduodenectomy

Conditions: Pancreatic Fistula

Summary: pancreatoduodenectomy (pd) is performed in many high volume centers with a very low mortality. reduced mortality rate is largely the result of careful patient selection, improved intraoperative management and a better postoperative care. unfortunately, there is not a similar reduction in morbidity rates which remains about 40%. persistent morbidity is predominantly due to pancreatic fistula (pf). abdominal abscess and hemorrhage are common sequelae of pf which have been associated with a high mortality rate. while many different risk factors have been reported, a soft pancreatic texture and a nondilated pancreatic duct have been most consistently linked to high rates of pf. a number of methods for reducing the incidence of pf have been proposed and analysed. many of these involve technical features of the anastomosis, including site of reconstruction, anastomotic technique, use of biologic glue, and prophylactic use of somatostatin analogue. the placement of a stent through the pancreatic anastomosis is an attractive strategy to reduce the pf rate. this multicenter prospective randomized trial was designed to compare the outcome after pd with external drainage stent versus no stent in patients with high risk of pf (with soft pancreas and a diameter of wirsung \<3mm). analysis:the primary objective of the study was to compare the incidence pf in patients with or without external pancreatic stent. with an anticipated pf rate of 30%, based on literature experience, it was calculated that a reduction to 10% of pf rate would require the inclusion of 75 patients in each group (statistical significance p \< 0.05 and power 80 per cent with a two-tailed test of proportions). we'll enroll 158 patients to take into account the possibility of 5% being lost to follow-up.

analysis: the primary objective of the study was to compare the incidence pf in patients with or without external pancreatic stent. with an anticipated pf rate of 30%, based on literature experience, it was calculated that a reduction to 10% of pf rate would require the inclusion of 75 patients in each group (statistical significance p \< 0.05 and power 80 per cent with a two-tailed test of proportions). we'll enroll 158 patients to take into account the possibility of 5% being lost to follow-up. pf was defined, according to the international study group of pancreatic fistula, as amylase rich fluid (amylase concentration more than three times serum concentration) collected from the drainage placed intraoperatively from day 3 or by needle aspiration of an intraabdominal collection. pf were graded according to the clinical impact on the patient's hospital course (grades a,b,c).

Eligibility criteria:
inclusion criteria: * all patients scheduled for elective pd, * confirmation of the soft pancreas or nondilated pancreatic duct during pd. exclusion criteria: * age less than 18 year, * emergency surgery, * previous pancreatic surgery, * previous susmesocolic radiotherapy.

Keywords: pancreaticoduodenectomy
discontinuation study of citalopram (antidepressant) in depressed adolescents

Conditions: Major Depression

Summary: the purpose of the study is to evaluate whether it is advantageous for adolescents who have recovered from depression after a 6 to 12 week course of antidepressant treatment to stay on the treatment a further 6 months or is it just as helpful to stop the medication after recovery. the hypothesis is that adolescents with major depression who recover from the 6 to 12 week trial of citalopram will be less likely to have a recurrence of depression over a 6 month period if continued on the citalopram as compared to those who discontinue the medication.


Eligibility criteria:
inclusion criteria: * diagnosis of major depression. * age 13-18. * a score of \> 16 on the 17 item hamilton depression scale or a score of \> 12 on the 17 items plus a score of \>7 on the atypical items. * males and females. * outpatient at initiation of double blind treatment phase. * ability to give informed consent. exclusion criteria: * past or current hypomanic or manic episode. * currently meets criteria for a conduct disorder. * current psychotic symptoms. * substance dependence in the last 3 months. * significant medical condition that would contraindicate the use of an antidepressant. * pregnancy * past treatment with citalopram for major depression
action in diabetes and vascular disease preterax and diamicron mr controlled evaluation post trial observational study

Conditions: Diabetes Mellitus, Type 2

Summary: the study is designed to determine the long term, post trial effects of the two interventions studied in advance (routine blood pressure lowering with perindopril-indapamide as compared with placebo and intensive gliclazide-mr based glucose control as compared to standard guideline based glucose control) in individuals with type 2 diabetes at high risk of cardiovascular events. the long term, post randomization effects of the two study interventions will be investigated separately as they were for the main trial. this study will clarify and quantify the long-term, post trial (often referred to as legacy) effects of these two interventions in a broader population of patients with type 2 diabetes from high and low to middle income countries, and in the setting of comprehensive cardiovascular risk factor treatment. with the advance trial infrastructure and surveillance system already in place, the implementation of extended follow-up will be feasible. the conclusions of this follow up study will have profound clinical implications for the care of patients with type 2 diabetes around the world.

the long term, post randomization effects of the two study interventions will be investigated separately as they were for the main trial. this study will clarify and quantify the long-term, post trial (often referred to as legacy) effects of these two interventions in a broader population of patients with type 2 diabetes from high and low to middle income countries, and in the setting of comprehensive cardiovascular risk factor treatment. with the advance trial infrastructure and surveillance system already in place, the implementation of extended follow-up will be feasible. the conclusions of this follow up study will have profound clinical implications for the care of patients with type 2 diabetes around the world.

Eligibility criteria:
inclusion criteria: * participated in advance * ability to provide informed consent exclusion criteria: * none

Keywords: diabetes mellitus, type 2
pectoral nerve block for analgesia after breast augmentation

Conditions: Ambulatory Plastic Surgery; Esthetic Prosthetic Breast Expansion

Summary: breast augmentation is among the most popular surgical procedures performed in the world with approximately 1,773,584 performed in 2013. this surgical intervention generates important pains during postsurgical recovery. a multimodal analgesia, based on the recommendations is proposed to the patients .the pectoral nerve block is an innovative technique of locoregional anesthesia that has already been successfully used in breast surgery. its realization is fast, simple, and it would be superior compared with a paravertebral block within the framework of mastectomy. the interest of this technique has never been assessed in esthetic breast surgery. the aim of this study is to evaluate the analgesic efficacy of the association of " pecs blocks 1 and 2 " on pain intensity after breast augmentation surgery.

the investigators hypothesized that the "pecs blocks 1 and 2" will provide a decrease of the maximal pain of the first 6 post-operative hours after prosthetic breast expansion. the pain will be assessed according to a numerical scale. this prospective, randomized, double blind study will include 92 patients successively during two years, randomized into two arms : pecs group and control group, which will respectively have the block, and no block. the rest of the anesthesic and surgical care will be identical. an intervention team (which will be different from the anesthesic team), will be alone with the patient for 15 minutes, and will realize or not the pecs blocks according to the previous randomisation so that all caregivers taking in charge the patients as well as research observers will be blinded.

Eligibility criteria:
inclusion criteria: * affiliated to a national insurance scheme * having signed the informed consent for this study * score of american society of anesthesiology ( asa) 1-3 * be hospitalized in the ambulatory care unit (uca) or plastic surgery service for a scheduled esthetic prosthetic breast expansion surgery. exclusion criteria: * protected minor or major patients or in the incapacity to give his consent according to the article l1121-8 of the code of the health public. * pregnant or breast-feeding women according to french law. * vulnerable people. * patients participating in another research * allergy with local anesthetics. * severe coagulopathy. * chronic painful patients (long-term treatment by analgesics) * contraindication to use analgesics of the protocol. * change of breast prostheses

Keywords: prosthetic breast surgery locoregional anesthesia pectoral nerve block pain postoperative analgesia
evaluation of locomotor activity before and after total hip replacement in patients with hip osteoarthritis.

Conditions: Hip Osteoarthritis; Indication for Total Hip Replacement

Summary: the investigators believe that the application of non-linear methods of analysis using the ganglion and neural network technique will make it possible to analyse all of the complex data obtained in patients with hip osteoarthritis before and then after total hip replacement, and should allow us to identify a combination of objective variables to classify the surgery as " successful " or " unsuccessful ". to this end, the study will take place as follows: step 1: screening, and inclusion. step 2: evaluation of the hip osteoarthritis and analysis of locomotor activity step 3: total hip replacement step 4: clinical evaluation of locomotor activity carried out between 6 months and 1 year after the thr step 5: data analysis


Eligibility criteria:
inclusion criteria: control group: * subjects who have provided written informed consent * subjects covered by the national health insurance scheme * men or women aged between 25 and 85 years * able to understand simple instructions and packaging instructions and able to give informed consent patients group: * patients who have provided written informed consent * patients covered by the national health insurance scheme * men or women aged between 25 and 85 years * able to understand simple instructions and packaging instructions and to give their informed consent * suffering from hip osteoarthritis defined according to acr criteria * most recent radiography examination less than 6 months earlier * radiological stage ii, iii or iv hip osteoarthritis according to the kellgren and lawrence classification * presenting with an indication for total hip replacement, according to the surgeon's usual criteria exclusion criteria: control group: * hip osteoarthritis or other arthrosis in the lower limbs * pregnant or breast-feeding women * disorders that may interfere with gait analysis * disorder that may be destabilized by gait analysis * neurological disease and/or motor neuron disease patients group: * contra-indication for total hip replacement * repeat surgery for total hip replacement * impossibility to use a standard implant * pregnant or breast-feeding women * inflammatory flare of the hip osteoarthritis * disorder that may interfere with gait analysis * disorder that may be destabilized by gait analysis * rapidly destructive hip osteoarthritis * neurological disease and/or motor neuron disease * hip dysplasia requiring thr to be completed using a graft