Kornimate/medical-research-clean huggingface dataset:
cryoablation with or without serplulimab in treating patients with stage i-iia non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: cryoablation is a minimally invasive technique that utilizes very low temperature to eliminate tumour cells for patients ineligible for surgery. it has been reported that cryoablation may enhance immune response and synergize with immunotherapy. this study is a multicenter, randomized, controlled, exploratory trial, and is expected to enroll a total of 134 patients. the enrolled patients were stage ia, ib, or iia lung cancer with negative driver gene mutations, who are considered high-risk for surgery or refuse surgery based on multidisciplinary evaluation. eligible patients will be randomly assigned in a 1:1 ratio to receive either cryoablation alone (ca group) or cryoablation combined with immunotherapy (i-ca group). the study aims to evaluate the safety and clinical benefits of combining immunotherapy with cryoablation in the treatment of early-stage nsclc by comparing progression-free survival (pfs), objective response rate (orr), overall survival (os), and the incidence of adverse events between the two groups.


Eligibility criteria:
inclusion criteria: 1. pathologically diagnosed as primary peripheral non-small cell lung cancer, preoperative staging suggested stage ia, ib, or iia (size≤5 cm, t1-t2n0m0), according to the 9th edition of the tnm classification for lung cancer; 2. negative driver gene mutation: driver genes were defined as egfr, alk, etc; 3. age ≥18 years old; 4. the ecog ps score is 0-2; 5. expected survival ≥3 months; 6. patients who are considered high-risk for surgery/radiotherapy or refuse surgery/radiotherapy based on multidisciplinary evaluation; 7. patients who have not received previous immunotherapy with pd-1, pd-l1 or ctla-4 antibodies; 8. all patients must agree to receive cryoablation (with or without serplulimab) as an initial therapy and sign a study-specific consent form. exclusion criteria: 1. patients with poor cardiopulmonary function or other comorbidities who cannot tolerate multimode thermal therapy; 2. patients whose chest ct indicated that the lung lesions could not be reached percutaneously or transbronchially; 3. severe liver and kidney function and coagulation function abnormalities, platelet count \&lt;70×109/l; 4. patients who have received other anti-tumor drugs in the past 6 months or have used immune checkpoint inhibitors before; 5. the patient has an uncontrolled disease (including but not limited to active infection, symptomatic congestive heart failure, unstable angina, arrhythmia, mental illness, etc.); 6. primary immune deficiency or autoimmune diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus, etc.); 7. pregnant and lactating women; 8. long-term use of steroid; 9. other circumstances considered inappropriate for participation in this study.

Keywords: cryoablation serplulimab early non-small cell lung cancer
efficacy of n-acetylcysteine in treatment of overt diabetic nephropathy

Conditions: Diabetic Nephropathy; Chronic Kidney Disease; Diabetes Type 2

Summary: diabetic nephropathy has become the single most frequent cause of end-stage renal disease. on a molecular level, at least five major pathways have been implicated in glucose-mediated vascular and renal damage and all of these could reflect a single hyperglycaemia-induced process of overproduction of reactive oxygen species. recent studies have shown that inflammation, and more specifically pro-inflammatory cytokines play a determinant role in the development of micro- vascular diabetic complications, most of the attention has been focused on the implications of tnf-α in the setting of diabetic nephropathy. glutathione is the most abundant low-molecular-weight thiol, and glutathione/ glutathione disulfide is the major redox couple in animal cells. n-acetylcysteine is effective precursors of cysteine for tissue glutathione synthesis. not only does n-acetylcysteine exhibit antioxidant properties, but it may also counteract the glycation cascade through the inhibition of oxidation. n-acetylcysteine can also reduce the apoptosis elicited by reactive oxygen species . indeed, n-acetylcysteine has been shown to inhibit reactive oxygen species induced mesangial apoptosis and to be able to protect cells from glucose-induced inhibition of proliferation.


Eligibility criteria:
inclusion criteria: * diabetic patients with more than 500 mg protein in 24 hours urine protein sample * males and post-menopausal non-lactating and non-pregnant females. * age greater than or equal to 30 years of age. * serum creatinine less than 3.0 mg/dl (265 micromoles per liter) * willing and able to give informed consent exclusion criteria: * type 1 (insulin-dependent; juvenile onset) diabetes * patients with known non-diabetic renal disease * renal allograft * myocardial infarction, coronary artery bypass graft surgery, or percutaneous transluminal coronary angioplasty/stent within 3 months of study entry * cerebrovascular accident within 3 months of study entry * new york heart association functional class iii or iv * known allergies or intolerance to n-acetylcysteine * untreated urinary tract infection or other medical condition that may impact urine protein values.

Keywords: diabetic nephropathy proteinuria antioxidant
double lock versus continuous non-locking technique for closure of rectus sheath in cesarean sections on post-operative pain

Conditions: Postoperative Pain

Summary: in this trial we compare the effect of 2 closure techniques of the rectus sheath during cesarean sections on postoperative pain. one closure technique is double lock technique and the other is the conventional continuous non-locking technique.


Eligibility criteria:
inclusion criteria: * first cesarean section exclusion criteria: * urgent cesarean section * previous abdominal surgery * previous cesarean section * obstetric and medical complications
predicting normal vs. carrier status in euploid embryos of translocation carriers

Conditions: Balanced Chromosomal Translocation

Summary: the purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (ivf) from patients carrying a balanced translocation.

this study aims to evaluate the validity of using informative snps to distinguish balanced from normal embryos. this will involve acquiring material from families to set phase for informative snps, evaluation of existing and new embryo snp array data, and follow up analysis of children born after applying the procedure.

Eligibility criteria:
inclusion criteria: * patients with balanced translocations who have undergone ivf exclusion criteria: * those who do not wish to know their child(s) karyotype

Keywords: translocation
mfolfox6 chemotherapy with apatinib as postoperative treatment in stage iiib or iiic colorectal cancer

Conditions: Apatinib

Summary: this study will focus on postoperative patients of stage iiib or stage iiic colorectal cancer. these patients will start to accept chemotherapy in 3-4 weeks after operation, these patients were randomly divided into two groups, one group will accept adjuvant chemotherapy of mfolfox6; another group will use mfolfox6 combined with apatinib. the efficacy and safety of adjuvant chemotherapy will be compared between the two groups. disease-free survival, overall survival, incidence of adverse reaction of chemotherapy and postoperative quality of life will be recorded.


Eligibility criteria:
inclusion criteria: 1. signed informed consent form; 2. confirmed as colorectal cancer by pathology, and the stage is iiib /iiic according to the nccn guidelines; 3. patients with primary colorectal cancer; 4. radical resection of colon cancer (cme) or radical resection of rectal cancer (tme) has done; 5. 3\~4 weeks after radical resection ; 6. patients did not receive any radiotherapy and chemotherapy before operation exclusion criteria: 1. emergency operation for colorectal cancer patients; 2. the situation after operation can not tolerance for systemic adjuvant chemotherapy (hemoglobin \ 2.5n, alanine aminotransferase \>2.5n, alkaline phosphatase \>2.5n, urea nitrogen \>2.5n, creatinine \>2.5n, proteinuria, hematuria, temperature of \>38 degree); 3. serious diseases such as cardiac insufficiency, respiratory insufficiency, liver and kidney dysfunction, serious blood diseases; 4. patients participated in other clinical trials at the same time; 5. pregnant or perinatal women; 6. combined with other malignant tumors; 7. a history of neuropsychiatric disorders; 8. patients have used anti angiogenesis targeted drugs (such as bevacizumab, cetuximab); 9. patients had a history of severe trauma within 4 weeks before admission; 10. allergic to chemotherapy drugs or apatinib; 11. active bleeding, ulcers, intestinal perforation, intestinal obstruction, hypertension
post-dilatation for optimization of drug-eluting stents (des) deployment assessed by intravascular ultrasound multicenter analysis

Conditions: Implant

Summary: comparison with use of intravascular ultrasound (ivus) analysis of two methods of percutaneous coronary interventions (pci) with drug eluting stent: after successful drug eluting stent implantation, patients were randomized into two groups: group a had no further dilatation, and group b had additional post-dilatation with a noncompliant balloon. the investigators performed ivus analysis in groups a and b just before randomization and after post-dilatation in group b.

stent expansion of des using current stent deliver systems is frequently suboptimal. further more smaller minimal stent area (msa) and stent underexpansion following deployment of des are strong predictors of stent thrombosis and (tvr) target vessel revascularization. the investigators hypothesize than adjunctive postdilatation with noncompliant balloon can improve des deployment. after successful drug eluting stent implantation, patients will be randomized into two groups: group a with no further dilatation, and group b with additional post-dilatation with a noncompliant balloon. the investigators will performed ivus analysis in groups a and b just before randomization and after post-dilatation in group b. post dilatation will be performed with noncompliant balloon and with a nominal diameter 0.25mm larger than stent balloon. the primary endpoint is optimum stent deployment. for defining the optimal stent deployment the investigators use the ivus criteria adopted in the music study: complete apposition without underexpansion and with symmetric stent expansion. patients are eligible after successful drug-eluting stent implantation in a native coronary artery. patients with myocardial infarction or acute coronary syndrome will be excluded from the study.

Eligibility criteria:
inclusion criteria: * successful drug eluting stent implantation in a native coronary artery exclusion criteria: * percutaneous coronary intervention (pci) of left main coronary artery; * myocardial infarction; * acute coronary syndrome; * emergency pci; * pci for in-stent restenosis;

Keywords: post-dilatation noncompliant balloon optimal stent deployment of drug-eluting stent intravascular ultrasound (ivus) optimal stent deployment defined by intravascular ultrasound analysis
facilitating treatment entry and family planning in substance-using neonatal intensive care unit (nicu) mothers

Conditions: Substance Use Disorders

Summary: the purpose of this pilot study is to assess whether the hospital-based, adaptive behavioral intervention strategy promotes treatment entry and reduces risk of additional substance-exposed pregnancies (seps), as well as hiv and hepatitis c virus (hcv) risks among substance-using nicu mothers. additionally, to assess whether the intervention increases use of professional obstetrical/gynecological resources for contraception to reduce substance-exposed pregnancies (seps).


Eligibility criteria:
inclusion criteria: * have an infant in the nicu at children's memorial hermann hospital (cmhh) * have a positive urine drug screen at delivery or have an infant with a positive urine or meconium drug screen or self-reported drug use to a healthcare provider or had a documented positive drug screen during pregnancy * have access to a telephone. exclusion criteria: * currently attending substance abuse treatment * severe cognitive, and/or psychiatric impairment, per judgment of nicu and research staff, that precludes cooperation with study protocol * inability to read, write, speak english or spanish * inability or unwillingness to provide signed consent for participation; (5) inability or unwillingness to meet study requirements.
comparison of intraligamentary anesthesia with the inferior alveolar nerve block for the extraction of mandibular molars.

Conditions: Tooth Extraction; Tooth Extraction Site Healing

Summary: local anaesthesia or numbing is done before tooth extraction. this study compares two different methods of numbing molar teeth before extraction. it compares them on the basis of pain during the procedure and on discomfort after the procedure as well. it will help dentists better understand the benefits of the two techniques, and their usage case to case.

the study was designed as a randomized controlled trial. the purpose of this study was to examine the differences in efficacy of the intraligamentary anaesthetic technique and the inferior alveolar nerve block for mandibular posterior tooth extraction cases. pain intensity, duration of anaesthesia, incidence of post-operative dry socket, success rates, onset of anaesthesia were examined. it was done in a split-mouth method so that two different techniques were used in the same patient, thus minimizing individual variations.

Eligibility criteria:
inclusion criteria: * patients of both sexes who were more than 18 years of age; they had indications of non-surgical extraction of one or multiple mandibular posterior teeth. exclusion criteria: * for patients: pregnancy, immunological compromise, systemic conditions requiring special considerations and non-compliance. * the exclusion criteria for individual teeth were: acutely infected teeth or any teeth with the instances of expression of pus through sinus tracts or the gingival sulcus were excluded. in case of multiple unilaterally indicated teeth that were to be extracted under ianb, only the tooth best fitting all criteria was considered for the study.

Keywords: intraligamentary anaesthesia inferior alveolar nerve block tooth extraction dry socket
dp-vpa for migraine prophylaxis, a pilot efficacy study

Conditions: Migraine

Summary: the study will evaluate if dp-vpa, a derivative of valproate (a drug that is commonly used for the prevention of migraine attacks), can reduce the rate of migraine attacks. migraine patients will take dp-vpa or placebo (an inactive look-alike drug) every morning and will have to report any migraine attacks they have during the study's 18-week follow up.

the multi-center trial has a double-blind, randomized, placebo-controlled, parallel-group design and will be carried out in israel. approximately 40 adult subjects with migraine will be randomly assigned (1:1) to either dp-vpa (maximum of 900mg/day) or placebo. active and placebo will be administered orally and once-daily on an add-on basis, i.e. other permissible ongoing medications will be continued. total study duration per subject will be 18 weeks. subjects will report on their migraine attacks frequency and other attack characteristics using weekly diaries.

Eligibility criteria:
inclusion criteria (abridged) * male and female subjects with migraine with or without aura fulfilling the diagnostic criteria of the international classification of headache disorders * 3 to 6 migraine attacks per month * concomitant prophylactic migraine treatment with a beta-blocker or amitriptyline that has been stable in the proceeding 3 months. no changes in this concomitant treatment will be allowed until the end of study follow-up. exclusion criteria (abridged)chronic migraine (\>15 days of migraine/ month). * migraine complicated by medication-overuse headache. * allergy or hypersensitivity to valproic acid, valproate sodium, or soy. * known contraindications to valproic acid. * pregnancy. * breastfeeding female subjects. * subjects with significant hepatic dysfunction indicated by sgot or sgpt \>3 times the upper limit of normal at screening. * renal impairment indicated by serum creatinine \>1.5mg/dl at screening. * potentially fertile and sexually active women who do not practice reliable contraception. * men who do not practice reliable barrier contraception. * concomitant use of antipsychotic, antidepressant or antiepileptic therapy - with the exception of amitriptyline - within 1 month of screening, or a medical condition that is likely to require such treatment during the trial participation. * an active central nervous system disease deemed to be unstable or progressive during the course of the study that may confound the interpretation of the study results. * any medical disorder that may makes the subject unlikely to fully complete the study- blood coagulation disorder. * concomitant drugs known to interact with vpa.- alcohol or other drugs abuse. * therapy with another investigational product within 30 days prior start of study. * concomitant participation in another trial or study
the impact of the covid-19 pandemic on the career choice of medicine

Conditions: Career Choice of Medicine

Summary: the aim of this study is to determine what impact the covid-19 pandemic may have had on the choices of high school students to pursue medicine as a career.

the covid-19 pandemic poses an unprecedented global health crisis that has affected healthcare systems around the world. those working in the health sector are at the forefront of this pandemic and naturally have been deeply impacted by it. health care workers are at risk of serious physical exhaustion owing to long shifts, a major increase in workload and working under high-stress conditions. shortage of personal protective equipment (ppe) in many hospitals carries a serious health risk for not only healthcare workers but their families and patients as well. in addition to the physical toll that the pandemic has taken on doctors and other healthcare professionals, it has also affected their mental health deeply with an increase in anxiety and depression. witnessing firsthand what this virus can do, yet stepping in daily into a high-risk area and exposing oneself to possible risk of infection, takes its toll on one's psychological well-being. however, the pandemic has allowed health care professionals to show higher levels of perseverance and professionalism in the face of the pandemic. in view of how the covid-19 pandemic has affected healthcare workers and the perception of the medical field around the world, the aim of this cross-sectional study is to determine what impact this may have had on the choices of high school students to pursue medicine as a career.

Eligibility criteria:
inclusion criteria: * age ≥ 14 years old and ≤ 20 years old * enrolled in a high school in pakistan for the academic year 2019-2020 * can communicate in english exclusion criteria: - studying a humanities, commerce, or pre-engineering track in high school

Keywords: medical education pre-medical
ozonated gel phonophoresis on chronic lateral epicondylitis

Conditions: Epicondylitis

Summary: comparison between 2 groups of chronic lateral epicondylitis, to determine the effect of ozonated media phonophoresis on chronic lateral epicondylitis.

40 patients (male and female), patients age would be ranged from 30 to 50 years, would be randomly allocated using sealed envelope into randomly two matched group (a and b), group a (experimental): 20 patients would receive ultrasonic with ozonated gel as a coupling medium (phonophoresis) (1 mhz, 1 w/cm2continuous mode) for 5 min. plus, conventional physical therapy program consists of (conventional tens (100 hz) for 30 min - hot pack for 20 min- stretching and strengthening exercises, wrist rest splints). 3 times per week for 4 weeks. group b (control):20 patients will receive conventional physical therapy program consists of (conventional tens (100 hz) for 30 min - hot pack for 20 min- stretching and strengthening exercises, wrist rest splints) 3times per week for 4 weeks.

Eligibility criteria:
inclusion criteria: * all patients would be diagnosed as chronic lateral epicondylitis from both genders. * patients with chronic lateral epicondylitis that diagnosed by orthopedist. * positive clinical manifestation in all patients. * pain onset is more than 3 months. * all participants must be medically stable and not be treated with analgesics or any medication which may cause misleading results. * all patients had body mass index between 18.5 and 29.9 kg/m2. exclusion criteria: * subjects would be excluded if they have: received intra articular injection from duration less than 3 months. * elbow instability. * history of cancer. * pregnancy * infection. * skin diseases on elbow area. * open wound in elbow. * shoulder or elbow fractures * systemic diseases such as rheumatoid arthritis, reiter's syndrome, or diabetes. * neurological diseases. * severe medical or psychiatric disorders. * elbow surgery. * entrapment of the radial nerve. * arthritis and effusion of the elbow.
clinical wound healing after lower 3rd molar fully-impacted surgery with 2 types of flap

Conditions: Wound Heal; Quality of Life; Dehiscence

Summary: the dehiscence distal to the second molar after lower third molar extraction is very common because the access flap for surgical extraction cannot be repositioned on a portion of healthy bone to guarantee suture support. the healing process is therefore delayed and the possible accumulation of food and debris is often responsible for bad smell and pain with the consequent occurrence of an overlapping infection. the main aim of the study is to evaluate whether healing is significantly different using two different flaps for surgical access. clinical assessment and a quality of life questionnaire are used for the evaluation.


Eligibility criteria:
inclusion criteria: * fully-impacted lower third molar * patients aged between 18 and 35 exclusion criteria: * patients undergoing drug treatment for systemic diseases that can influenced the healing process, * pregnant women, * smoking habits * patients with disabilities * all interventions in which intraoperative accidents involving the soft tissues occurred (laceration of the mucosa / flap).

Keywords: third molar surgery flaps health related quality of life
internal brace augmented anterior inferior tibiofibular ligament repair: post-operative syndesmotic volumes.

Conditions: Syndesmotic Injuries; Ligament Rupture; Bimalleolar Fractures; Trimalleolar Fractures

Summary: over the course of a year from the start of the research study, twenty subjects will be randomized evenly into one of two groups after an informed consent is obtained: a traditional tight rope fixation group or a tight rope fixation with an anterior inferior tibiofibular ligament (aitfl) repair augmentation with an internal brace group. postoperative reduction was assessed by 3d volumetric ratios and measured by weight-bearing ct at 6-weeks and 3-months post-operation. patient reported outcomes (pros) were collected preoperatively, and at 6-weeks, 3-months, 6-months, and 1-year post-operation and included the foot and ankle outcome score and the 36-item short form survey instrument (rand-36) . differences in volumetric ratios and pros were evaluated between groups and time periods.


Eligibility criteria:
inclusion criteria: * patients who fit the study injury list exclusion criteria: * smokers * prior surgery on ankle * bi-lateral surgery * recent participation in another study within the last 90days