Kornimate/medical-research-clean huggingface dataset:
nature 3.1_new approach for the reduction of renal uremic toxins

Conditions: Chronic Kidney Diseases; Healthy

Summary: the objective of the pilot study is to validate the clinical use of an innovative symbiotic in patients with chronic kidney disease (ckd) stage 3b-4 and in healthy subjects. the study aims at evaluating the effects of a symbiotic, consisting of a mixture of probiotics (lactobacilli and bifidobacteria), prebiotics (fructooligosaccharides and inulin) and natural antioxidants (a mix of quercetin, resveratrol and proanthocyanidins), by achieving two objectives: 1. reduction of the serum levels of microbiota-derived uremic toxins, involved in a variety of cardiovascular complications in ckd 2. reduction of intestinal permeability, inflammatory markers and oxidative stress


Eligibility criteria:
ckd patients inclusion criteria: * ckd patients stage 3b-4 not on dialysis * aged between 30 to 65 * bmi between 18.5 and 29.9 * controlled diet * informed consent signed exclusion criteria: * type 2 diabetes mellitus * use of antibiotics or probiotics up to 30 days prior to recruitment * chronic gastrointestinal disorders * systemic inflammatory diseases * suspicion or clinical diagnosis of malignancy * chronic liver disease * treatment with corticosteroids or immunosuppressive drugs * previous acute cardiovascular diseases (myocardial infarction, stroke) * psychiatric conditions reducing the compliance to treatment protocols healthy volunteers inclusion criteria: * healthy subjects * aged between 35 to 60 * bmi between 18.5 and 29.9 * medium score of adherence to mediterranean diet (predimed score between 6 and 9) * informed consent signed exclusion criteria: * type 2 diabetes mellitus * use of antibiotics or probiotics up to 30 days prior to recruitment * chronic gastrointestinal disorders * systemic inflammatory diseases * suspicion or clinical diagnosis of malignancy * chronic liver disease * treatment with corticosteroids or immunosuppressive drugs * previous acute cardiovascular diseases (myocardial infarction, stroke) * psychiatric conditions reducing the compliance to treatment protocols

Keywords: gut microbiota dysbiosis uremic toxins symbiotic
"hyaluronan" formulation for type 2 diabetic patients with dry mouth

Conditions: Dry Mouth; Xerostomia; Type 2 Diabetics

Summary: an increased incidence of dental caries in association with poorly controlled diabetes has also been reported, xerostomia (dry mouth) has been reported to be a common complaint of patients with diabetes, without adequate saliva production, both hard and soft tissues of the mouth can be severely damaged and become more susceptible to infections. this 9 week, cross-over group, randomized, single center, study will evaluate the efficacy of ha formulation in alleviating dry mouth in type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: 1. patient should be above 18 years of age. 2. patients who have been diagnosed with type 2 diabetes and have developed dry mouth or have worsening of pre-existing dry mouth condition. 3. ability to attend visits at the research site 4. patient should be able to read and/or understand and sign the consent form and be willing to participate in the research study 5. agree to abstain from the use of any products for xerostomia other than those provided in the study. 6. agree to comply with the conditions and schedule of the study. exclusion criteria: 1. subjects with open mouth sores at study entry. 2. any pathology that, based on the judgement of the researcher, could negatively affect the oral mucosa and subsequent treatment for xerostomia. 3. subjects who are nursing, becoming pregnant or plan to become pregnant during the study period 4. subjects currently on medication or treatment for dry mouth/xerostomia 5. hypersensitivity to any of the following ingredients- ha ,xylitol and sodium benzoate. 6. subjects with soft or hard tissue tumor of the oral cavity. 7. presence of severe gingivitis. 8. chronic disease with concomitant oral manifestations other than xerostomia 9. history of radiation therapy to head and neck 10. subjects with conditions the investigator may feel will interfere with the study.
effect of playstation distraction in the dental setting

Conditions: Global Behaviour Measure

Summary: the aim of the study was to assess whether the behavior, anxiety, and dental pain of pediatric patients during dental treatment improves when a video game is played as method of distraction.

global behavior parental perception of patients' anxiety patient's anxiety dental pain heart rate

Eligibility criteria:
inclusion criteria: * patients aged 6-8 years. * patients who required a minimum of 2 visits for restorative treatment. exclusion criteria: * patients with reduced audiovisual capabilities. * patients with psychological disorders.

Keywords: audiovisual distraction pediatric dentistry
the motor imagery based on action observation treatment on dysphagia in wallenberg syndrome

Conditions: Lateral Medullary Syndrome; Deglutition Disorders

Summary: the goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. the main questions it aims to answer are: * the efficacy of motor imagery based on action observation treatment in the rehabilitation of patients with dysphagia in wallenberg syndrome. * apply functional near infrared spectroscopy to explore the mechanism of action of this therapy. participants received conventional dysphagia treatment and motor imagery based on action observation treatment once a day for 14 days. researchers compared the control group to see the effect and mechanism of motor imagery based on action observation treatment.

the goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. the main questions it aims to answer are: * the efficacy of motor imagery based on action observation treatment in the rehabilitation of patients with dysphagia in wallenberg syndrome. * apply functional near infrared spectroscopy to explore the mechanism of action of this therapy. both groups received conventional dysphagia treatment, and the experimental group underwent the addition of motor imagery based on action observation treatment to the control group once a day for 14 days. overall swallowing function was assessed before treatment and after 14 days of intervention. meanwhile, the functional near infrared spectroscopy was used to detect changes in cerebral hemodynamics during the execution of volitional swallowing task and swallowing motor imagery.

Eligibility criteria:
inclusion criteria: * age ranged from 18-80 years and right-handed; * first onset, vital signs stable and conscious; * the dysphagia confirmed by videofluoroscopic swallowing study; * no cognitive impairment, the mini-mental state examination score: \>17 for those with an illiterate education, \>20 for those with an elementary education, and \>24 for those with a secondary education and above; * good motor imagery ability with kinesthetic and visual imagery questionnaire-10 score ≥25; * cranial integrity without craniotomy and/or craniectomy; * patient and/or his/her relative agrees and signs written informed consent. exclusion criteria: * combined ischemic foci at other sites; * presence of organic swallowing dysfunction or pre-existing dysphagia due to parkinson's disease, dementia, and others; * severe cardiac, pulmonary, hepatic, and renal insufficiency and vital organ failure; * significant psychological disorders such as anxiety and depression; * infected or broken skin on the head; * poorly controlled epilepsy; * poor patient compliance.
the effect of antenatal corticosteroid on umbilical artery doppler velocimetry in iugr

Conditions: Intrauterine Growth Restriction

Summary: the purpose of this study is to evaluate the effect of antenatal corticosteroid administration on umbilical artery doppler velocimetry measurements in pregnancies complicated by iugr.

this study was conducted with pregnant women who were likely to have preterm birth and were treated with antenatal corticosteroids. betamethasone was used as an antenatal corticosteroid. ua doppler measurements (pi, s/d ratio, ri) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated in pregnant groups complicated with iugr and uncomplicated with iugr and compared with each other.

Eligibility criteria:
inclusion criteria: pregnant women who were likely to have preterm delivery and were treated with antenatal corticosteroids. exclusion criteria: pregnant women who had complicated pregnancy with fetal anomaly, who had multiple pregnancies, who left their pregnancy follow-up unfinished, and those under 18 years of age were excluded from the study.
dexmedetomidine vs propofol sedation reduces postoperative delirium in patients receiving hip arthroplasty.

Conditions: Anesthesia; Local Anesthesia

Summary: with blocks of lumbar and lumbar plexus, we can reduce the intravenous anesthetics usage. to offer an satisfied surgery process for patients, a proper sedation is necessary. so in this study, we want to investigate the influence of two different sedative drugs on outcomes of patients received hip replacement surgery .


Eligibility criteria:
inclusion criteria: * 65 years or older and undergoing hip fracture repair exclusion criteria: * patients with severe cognitive impairment (mmse score, \<15) * preoperative delirium as determined by confusion assessment method * contraindications to local anesthesia * prior hip surgery * mental or language barriers that would preclude data collection * severe congestive heart failure (newyork heart association class iv) * severe chronic obstructive pulmonary disease (global initiative for chronic obstructive lung disease guidelines, stage iii-iv)
randomized controlled trial of treating migraine with acupuncture

Conditions: Migraine

Summary: the purpose of the study is to testify whether acupuncture is effective for migraine, and provide evidence for the hypothesis that"acupuncture effect is based on meridians, and gathering of meridian qi is the key point."

the purpose of the study is to testify whether acupuncture is effective for migraine, through treating migraine patients for a month, using different acupoints according to literatures of treating migraine with acupuncture, and try to provide clinical evidence for the hypothesis that"acupuncture effect is based on meridians, and gathering of meridian qi is the key point."

Eligibility criteria:
inclusion criteria: 1. age of a subject is older than 18 and is younger than 65.(the subject is younger than 50 when he was ill for the first time.) 2. consistent with the diagnostic criteria of premonitory migraine and non- premonitory migraine. 3. attacks of migraine are equal to or more than 2 times in the last three months. 4. with more than one year history of migraine 5. informed consent is signed by a subject or his lineal relation. exclusion criteria: 1. with serious protopathy or disease of cardiovascular, liver, renal,gastrointestinal, hematological systems and so on. 2. psychotic，patients with allergic constitution or easily getting infected or bleeding. 3. patients have used drugs for preventing migraine in the last four weeks. 4. pregnant women or women in lactation.

Keywords: migraine acupuncture efficacy safety meridian acupoint
a study of trastuzumab subcutaneous in participants with human epidermal growth factor receptor-2 (her2) positive early breast cancer

Conditions: Breast Neoplasms

Summary: this observational study will evaluate the efficacy, safety, tolerability and participant reported quality of life of trastuzumab (herceptin) subcutaneous (sc) therapy in participants with her2-positive early breast cancer in routine clinical practice. data from eligible participants will be collected for the duration of their treatment (approximately 1 year) and for 1-2 years of follow-up.


Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the breast * her2-positive tumor * eligible for neo-adjuvant or adjuvant treatment with trastuzumab sc according to the judgement of the physician note: as of participant recruitment (date of participant informed consent), retrospective documentation is allowed but limited to up to 9 weeks after initial start of therapy with trastuzumab sc exclusion criteria: * contraindications according to the summary of product characteristics of herceptin sc * pregnant and breastfeeding women
robotic lobectomy vs. thoracoscopic lobectomy for early stage lung cancer: rct

Conditions: Non-small Cell Lung Cancer; Thoracic Surgery

Summary: during video-assisted thoracoscopic lobectomy (vats), the surgeon inserts a small camera attached to a thoracoscope that puts the image onto a video screen. instruments are inserted via small incisions, and the lung resection is completed. robotic thoracic surgery (rts) uses a similar minimally invasive approach, but the very precise instruments involved with rts allow the surgeon to view the lung using 3-dimensional imaging. the instruments give the surgeons increased range of motion during the surgery, and research demonstrates that rts has a less steep learning curve as compared to vats. both vats and rts demonstrated better results as compared to traditional thoracotomy (open surgery). however, robotic lobectomy has not yet been compared directly to video-assisted thoracoscopic lobectomy (vats) in a prospective manner. there are two major barriers against the widespread adoption of robotic thoracic surgery. the first barrier is the lack of high-quality prospective data. to our knowledge, there are no prospective trials comparing vats to rts for early stage lung cancer. the second major barrier to the widespread adoption of robotic technology in thoracic surgery is the perceived higher cost of robotic lobectomy. to address these barriers, the investigators will undertake the first randomized controlled trial comparing thoracoscopic lobectomy to robotic lobectomy for early stage lung cancer. prospective randomization will eliminate the biases of retrospective data and will serve to determine whether there exist any advantages to health related quality of life (hrqol) or patient outcomes in favour of robotic lobectomy over vats lobectomy. furthermore, through a prospective cost-utility analysis, this trial will provide the highest quality data to evaluate the true economic impact of robotic technology in thoracic surgery in a canadian health system.


Eligibility criteria:
inclusion criteria: 1. age \>/= 18 years 2. clinical stage i, ii or iiia non-small cell lung cancer (nsclc) 3. candidates for minimally invasive pulmonary lobectomy, as determined by the operating surgeon. exclusion criteria: 1. clinical stage iiib or iv nsclc 2. not a candidate for minimally invasive surgery.
myocardial mechanisms in heart failure with preserved ejection fraction

Conditions: Heart Failure; Heart Failure With Preserved Ejection Fraction

Summary: the purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (emb or heart biopsy) during a right heart catheterization (rhc). the ultimate goal is to use this information to develop new treatments for heart failure.


Eligibility criteria:
inclusion criteria: * hfpef criteria 1. age ≥30 years. 2. left ventricular ejection fraction ≥50% measured by echocardiography, cmr or muga (measured within one year + clinical stability) 3. definition of hfpef: signs and/or symptoms of hf, nyha functional class ii-iv, and at least one of the following: 1. elevated bnp (≥75 pg/ml in sinus rhythm or ≥225 pg/ml in atrial fibrillation/flutter) or ntprobnp (≥225 pg/ml in sinus rhythm or ≥675 in atrial fibrillation/flutter) at baseline. choice of bnp or ntprobnp is based on availability at each clinical center. 2. prior hf hospitalization (primary reason for the hospitalization is hf with elevated natriuretic peptide levels \[using the thresholds listed above\], requiring iv diuresis for hf, or pulmonary edema or pulmonary vascular congestion on chest radiography). 3. previously documented elevated pulmonary capillary wedge pressure (pcwp) at rest (≥15 mmhg) or during exercise (≥25 mmhg for supine exercise or pcwp/cardiac output ratio ≥2 mmhg/l/min for upright exercise). 4. elevated h2fpef score69 (≥5) or hfa-peff70 score (≥5). suspected hfpef criteria 1. age ≥30 years. 2. left ventricular ejection fraction ≥50% measured by echocardiography, cmr or muga (measured within one year + clinical stability) 3. signs and/or symptoms of hf, nyha functional class ii-iv and all of the following: 1. does not meet bnp or nt-probnp criteria for hfpef (above) 2. no prior hf hospitalization meeting hf criteria (above) 3. no previous hemodynamic catheterization documentation of hf (as above) exclusion criteria: * 1. inadequate echo or fluoroscopic images. 2. neck anatomy unfavorable for jugular venous cannulation 3. therapy with direct oral anticoagulants without cessation for a period (age, renal function, and agent specific) deemed adequate to normalize coagulation according to local clinical guidelines. 4. previous or ongoing therapy with warfarin with inr ≥ 1.6 measured day before or of emb 5. platelet count \< 50,000/ml 6. active bleeding or coagulation disorder 7. infection or fever 8. endocarditis 9. pregnancy 10. intracardiac thrombus 11. rv aneurysm 12. clinically significant tricuspid, pulmonary or aortic valve stenosis 13. tricuspid or pulmonary mechanical valve prosthesis 14. left bundle branch block
managing cyanosis following bidirectional glenn operation

Conditions: Congenital Disorders

Summary: the purpose of this retrospective study is to review the postoperative medical management of infants who underwent bidirectional glenn operation from january 1, 2003 to december 31, 2005 who were significantly cyanotic.

infants following bidirectional glenn operation are at times significantly cyanotic. the medical management of significant postoperative cyanosis has changed with the advent of nitric oxide, sildenafil and bosentan. the purpose of this retrospective study is to review the postoperative medical management of infants who underwent bidirectional glenn operation from jan 1, 2003 to dec 31, 2005 who were significantly cyanotic. summary of procedures this is a retrospective study, therefore, the only procedure will be a chart review. i estimate the number of patients to be around 150, however, request permission to review the patient population in order to provide exact numbers. we request permission to review hospital charts from the time of bidirectional glenn operation and the last clinic note within the dates jan 1, 2003 to dec 31, 2005. we will assign each chart a unique study number and collect data of: date of follow-up oxygen saturation during stay time since discharge 02 saturation at home home medications when discontinue medications

Eligibility criteria:
inclusion criteria: * infants * bidirectional glenn operation between 1/1/03-12/31/05 * significant cyanosis exclusion criteria: * those who do not meet inclusion criteria.

Keywords: pediatric glenn operation cyanosis
differential effects of lipids on cardiovascular diseases: a caliber study

Conditions: Stable Angina; Unstable Angina; Non ST Elevation Myocardial Infarction; ST Elevation Myocardial Infarction; Myocardial Infarction Not Otherwise Specified

Summary: the role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. this study will examine a more refined set of endpoints.

the role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. the emerging risk factors collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (chd) death; ischaemic, haemorrhagic and unclassified stroke. they also found that triglycerides concentration was not independently related with chd risk after controlling for hdl cholesterol (hdl-c), non-hdl-c, and other standard risk factors. the prospective studies collaboration found that higher hdl-c and lower non-hdl-c levels were approximately independently associated with lower ischaemic heart disease mortality. by focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (cvd) phenotypes, disease progression and mortality from cardiovascular causes. with linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of cvd phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.

Eligibility criteria:
inclusion criteria: * aged 30 to 100, had at least one year of electronic health record data which meet general practice research database data quality standards exclusion criteria: * no record indicating any cardiovascular disease phenotypes
efficacy of clarithromycin and flouroquinolones based regimens in h.pylori eradication in covid-19 era

Conditions: Helicobacter Pylori Infection

Summary: era of covid-19 and the related panic lead to widely spread antibiotics misuse especially for azithromycin. cross sensitivity between azithromycin and clarithromycin can impact success rates of h. pylori treatment regimens.(1) here we aim to explore this point in egyptian patients. sample size supposing the cure rate of clarithromycin-based regimen to levofloxacin based regimen is 69% versus 84.5% respectively. using medcalc, the minimal required sample size is 116 patients for each arm (type 1 error= 5%, type ii error=20%). each arm increased by 10% to compensate for drop-out. the sample size will be 135 for each arm. study arms: * arm 1: the first group will receive (amoxicillin 1g/12 hrs, clarithromycin 500 mg/12hrs, esomeprazole 40mg/12hrs) * arm 2: the second group will receive (esomeprazole 40 mg/12hrs, levofloxacin 500 mg/24 hrs, and amoxicillin 1gm/12 hrs). * to confirm patient compliance, we will ask patients to bring their remaining medication and counted the rest of their pills. patients with a compliance of \<80% will be excluded from the study per protocol (pp) analysis.


Eligibility criteria:
inclusion criteria: * • patients aged 18-65 years old with newly diagnosed positive h. pylori antigen in stools, urea breath test or h. pylori detected on endoscopy. exclusion criteria: * • women who are pregnant or lactating, patients previously treated with h. pylori eradication therapy, those with recent exposure to antibiotics within the previous 3 months, patients who previously underwent gastric surgery, patients with malignant neoplasms, and patients with other severe concomitant diseases like renal, hepatic impairement, heart failure nyha class ii or more, hypoalbuminemia and those with possible clinically significant drug-drug interaction with any of the study's drugs will be excluded. * known allergy to antibiotics.
safety profile following pentabio vaccination in indonesian infants

Conditions: Healthy

Summary: to assess any serious systemic reaction within 30 minutes after pentabio immunization

any local and systemic reaction after pentabio immunization

Eligibility criteria:
inclusion criteria: * immunization with pentabio vaccine * parents already understood the consequences to be involved in this study and having signed the informed consent form * parents agree and willing to fill in the diary card, to record all the reactions after immunization exclusion criteria: * given simultaneously with other vaccines or with the interval less than 1 month with other vaccination except opv/ipv.

Keywords: pentabio vaccine safety infants booster dose dtwp/hepb/hib