Kornimate/medical-research-clean huggingface dataset:
treatment of palmoplantar psoriasis with low doses interferential current

Conditions: Psoriasis Palm & Soles

Summary: interferential current has shown promising results for treating psoriasis with a good tolerance. prospective randomized studies versus placebo are required to confirm the interest of such an approach. the main objective is to assess the efficacy of interferential current for treating palmoplantar psoriasis. secondary objectives is to assess the subjective efficacy by the patients, the efficacy on the nails, to study the potential side effects.

interferential current has shown promising results for treating psoriasis with a good tolerance. prospective randomized studies versus placebo are required to confirm the interest of such an approach. main objective to assess the efficacy of interferential current for treating palmoplantar psoriasis. secondary objectives to assess the subjective efficacy by the patients, the efficacy on the nails, to study the potential side effects. patients patients from 18 to 90 year-old with psoriasis on the hands and/or feet. length of the study: 12 months methods monocentric randomized comparative study versus placebo.intervention v0 : selection: information of the patient, control of inclusion and non inclusion criteria. v1 : control of inclusion and non inclusion criteria (treatment against psoriasis have to be discontinued for at least 3 weeks and 3 months for anti-il12/23). clinical scores and photographs. explanation of the functioning of the device, then the treatment is followed at home, twice a day 5 minutes. 10% salicylic acid ointment will be applied after each session. v2 : end of the treatment (12 weeks after v1). clinical scores and photographs. v3 : end of the follow-up (24 weeks after v1). clinical scores and photographs.

Eligibility criteria:
inclusion criteria: * patients from 18 to 90 year-old with psoriasis on the hands and/or feet diagnosed clinically exclusion criteria: * pregnant women, * implantable electronic device (such as pace maker), betabloquer. * concomitant use of a treatment potentially active on psoriasis (steroids, vitamin d analogues, immunosuppressive drug, acitretin, cyclosporine, methotrexate, anti-tnf, anti-il12/il23).

Keywords: palmoplantar
comparison of higher order aberrations and contrast sensitivity between acrysof sn60at, sn60wf and restore intraocular lenses

Conditions: Refractive Errors

Summary: this project involves evaluation of post operative contrast sensitivity and wavefront aberration results among patients implanted with standard monofocal lenses (acrysof sn60at/sn60wf) and the new presbyopic correcting multifocal lens (acrysof restor). higher order aberrations are visual phenomena such as glare and haloes. they are more prevalent after cataract surgery and can affect night driving.

the project involves evaluation of contrast sensitivity and higher order aberrations in patients implanted with sn60at, sn60wf and restor intraocular lenses. patients in the department of ophthalmology will be asked to participate in the study on a routine postoperative visit at least 3 months after cataract surgery. patients will be asked to sign a consent form prior to participation. wavefront analysis involves the patient resting their chin in a device similar to a slit lamp; they focus on a distant light and the machine performs the measurements in mesopic and scotopic conditions (light and dark). contrast sensitivity is a measure of how faded or washed out an image can be before it becomes indistinguishable from a uniform field; it involves the patient identifying patterns on a chart. wavefront analysis and contrast sensitivity are noninvasive tests that do not employ sedation or anesthesia and does not expose the patient to x-rays or microwaves. the proposed research will not alter usual standard postoperative care and can be done on a routine office visit.

Eligibility criteria:
inclusion criteria: all subject implanted with either sn60at, sn60wf or restor intraocular lenses after cataract removal. subjects include those 18 yrs and over, male and female, all races. patients will sign an informed consent exclusion criteria: patients younger than 18 yrs. patients with other concurrent visually significant ophthalmic disease.
bringing the diabetes prevention program to geriatric populations

Conditions: Pre Diabetes

Summary: over 24 million americans are over 65 years and have prediabetes. prediabetes can be addressed using a public health approach: among the 20% of participants in the diabetes prevention program (dpp) who were ages 60 and over, the diet and physical activity intervention conferred a 71% risk reduction of diabetes after an average follow-up of 3 years. the population of older adults is projected to more than double from 52.5 million in 2019 to \~100 million by 2060, and if projections hold, about half (48.3%) will have prediabetes. the proposed hybrid effectiveness implementation type 1 design will compare a dpp program tailored for older adults and delivered via telehealth (dpp-toat arm) to an in person dpp tailored for older adults (dpp arm) using a randomized, controlled trial design (n=230). the preliminary data suggests dpp-toat is a feasible and acceptable way to deliver the dpp to older adults, and this will be the first study to compare the effectiveness and implementation of two strategies (telehealth versus in-person) to deliver a tailored dpp for the unique needs of the growing population of older adults.

eligible patients will be recruited through electronic health records (epic and mychart) and randomized to the 12-month dpp-toat or the in-person dpp program. primary effectiveness outcome will be 6-month weight loss and implementation outcome will be attendance. a pragmatic approach will be used in order to inform future studies conducted in community-based and rural settings. findings will inform best practices in the delivery of an evidence-based intervention that could reach the 30+ million adults aged 65 and over with prediabetes.

Eligibility criteria:
inclusion criteria: * men and women aged 65 years and older * diagnosis of pre-diabetes (a1c between 5.7-6.4%, fasting glucose between 100-125 mg/dl, or oral glucose tolerance test between 140-199 mg/dl within past 12 months) * bmi of greater than or equal to 30 * english-speaking * under the care of a primary care provider (pcp) in the nyu langone health system * able to travel to nyu langone for in-person evaluations * access to a telephone * informed consent exclusion criteria: * prevalent diabetes or end-stage renal disease * prior participation in the diabetes prevention program * a documented current history of active psychosis or other cognitive issues via international classification of diseases (icd) -10 codes * taking fda-approved weight loss medications * pcp stating that patient should not participate * inability to communicate due to severe, uncorrectable hearing loss or speech disorder * severe visual impairment that precludes completion of assessments and/or intervention
the effect of pork with modified fat composition and berries on plasma fatty acids and fecal compounds in healthy adults

Conditions: Cardiovascular Diseases

Summary: high consumption of red meat is related to cardiovascular diseases. red meat containing more unsaturated fat than normal red meat may have a beneficial impact on plasma lipid and fatty acid profile in humans. furthermore, consumption of red meat and especially processed red meat is considered harmful to colon health. however, consumption of fruit and berries rich in antioxidants and flavonoids may provide protection when red meat is consumed. the study aims to answer whether the fatty acid profile of pork when modified towards more unsaturated fat will affect plasma fatty acids and lipids in adult volunteers. the effects of pork with a modified fatty acid content is compared with conventional pork with lower unsaturated fat content. fatty acid composition of pork is modified by altering the composition of animal feed. the other arm of the study investigates the effects of consuming berries together with red meat on gut metabolism. the study focuses on how berries affect the formation of fecal compounds known to be related to high red meat consumption, such as n-nitroso compounds.


Eligibility criteria:
inclusion criteria: * diet includes meat exclusion criteria: * high consumption of fish (4 times per week) * use of fish oil/ omega-3 oil capsules one month before the intervention * hypercholesterolemia * vegetarian, vegan

Keywords: fatty acids lipids nitroso compounds lipid metabolism gut metabolism
effects of esketamine on consciousness-related brain network characteristics in patients with prolonged disorders of consciousness

Conditions: Prolonged Disorders of Consciousness

Summary: prolonged disorders of consciousness (pdoc) are pathologies in which there is a loss of consciousness for more than 28 days. the number of patients with pdoc is increasing as the level of critical care treatment and monitoring improves. however, clinical trials for patients with pdoc are limited by small sample sizes, lack of placebo groups, and use of heterogeneous outcome measures. as a result, few therapies have strong evidence to support their use. in recent years, ketamine has been used with remarkable success in the treatment of neuropsychiatric disorders by inducing neuroplasticity, increasing neurophysiologic complexity, and expanding functional brain connectivity states. considering increased brain plasticity as well as brain complexity, it may be beneficial for consciousness recovery. in this study, the investigators aimed to explore the effects of esketamine on brain networks and level of consciousness in patients with pdoc, and to discuss its possible use as a wakefulness-promoting treatment for patients with pdoc.


Eligibility criteria:
patients with prolonged disorders of consciousness: inclusion criteria: * age 18 - 65 years old, native chinese speaker, dextromanual; * chronic disorder of consciousness; * spinal cord electrical stimulator implantation under general anesthesia; * signed informed consent. exclusion criteria: * continuous sedation was administered within 72 hours prior to the study; * open head injury, parenchymal resection and other damage of brain structural integrity; * the intracranial compliance decreased due to hydrocephalus and swelling; * known hearing impairment; * airway stenosis and various causes of severe ventilation or ventilation dysfunction; * known or suspected severe cardiac, pulmonary, hepatic, and renal dysfunction; * history of drug allergy to esketamine; * associated with other mental or neurological diseases; * other reasons are not suitable to participate in this study. healthy brain volunteers: inclusion criteria: * age 18 - 65 years old; * patients undergoing surgical treatment under elective general anaesthesia; * american society of anesthesiologists (asa) i-ii; * native chinese speaker; * dextromanual; * signed informed consent. exclusion criteria: * previous history of craniocerebral disease, imaging suggests organic brain lesions; * people with uncontrolled hypertension, hyperthyroidism, elevated intracranial pressure, epileptic seizures; * history of drug allergy to esketamine; * hearing abnormality; * history of drug and alcohol abuse; * people with mental and behavioral disorders.

Keywords: esketamine multichannel electroencephalogram event-related potential brain network characteristics
comparison of effects of telmisartan and valsartan on neointima volume in diabetes

Conditions: Hypertension; Diabetes; Coronary Artery Disease

Summary: people with diabetes mellitus are more prone to coronary heart disease, stroke, and peripheral vascular disease, and diabetes mellitus has been regarded as an independent risk factor for the progression of coronary artery disease. several studies have been reported that diabetes increased the risk of cardiovascular mortality in both men and women. with the introduction of drug-eluting stents (dess), the angiographic rates of restenosis at later months have reduced dramatically in several studies. however, even with dess, diabetic patients showed increased rates of restenosis and late loss index compared with nondiabetic patients. diabetes has been considered to be a predictor of poor prognosis after percutaneous coronary intervention with drug-eluting stents. long-term clinical and angiographic outcomes after percutaneous coronary intervention (pci) with drug-metal stents (dess) have been demonstrated to be worse in diabetic patients compared with nondiabetic patients. in the era of dess, no study has compared the effects of telmisartan and valsartan on neointima volume with intravascular ultrasound (ivus) at 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients. telmisartan, which is well-known for its selective peroxisome proliferator-activated receptor (ppar)-γ activity with its anti-inflammatory and antiproliferative properties, could be an appropriate therapeutic option for treating hypertensive diabetic patients with significant coronary artery diseases requiring stent implantation. in contrast, valsartan is an angiotensin receptor blocker with negligible ppar-γ activity. increasing interest remains in the identification of systemic pharmacological therapies to prevent coronary restenosis especially in diabetic patients.


Eligibility criteria:
inclusion criteria: * age: 18 years and above * gender eligible for study: both * hypertensive diabetic patients either previously diagnosed or newly found. * systolic blood pressure ≥ 130 mmhg or diastolic blood pressure ≥ 80 mmhg for newly found hypertensive patients. * fasting blood glucose ≥ 126 mg/dl or pp2 blood glucose ≥ 200 mg/dl for newly found diabetes. * patients with significant de novo coronary artery disease (diameter stenosis \> 70%) requiring stent implantation (angina pectoris and/or exercise-induced ischemia). * patients with informed consent. exclusion criteria: * acute st-segment elevation myocardial infarction (mi), cto lesions, left main lesions * diabetic patients with the use of thiazolidinediones within 3 months * previous history of pci or bypass surgery * patients with any contraindications to the treatment of telmisartan or valsartan * pregnant or lactating patients * chronic alcohol or drug abuse * hepatic dysfunction * renal dysfunction * heart failure (ef \< 50%) * expected life expectancy of \< 1 year
analgesics in the pre-hospital setting: implications on hemorrhage tolerance - ketamine

Conditions: Hemorrhage; Healthy

Summary: the purpose of this project is to test how ketamine, an analgesics currently employed in the pre-hospital setting by the us army, alters the capacity to tolerate a hemorrhagic insult in humans.

pain management on the battlefield is critical for the wellbeing of the soldier. given that a hemorrhagic injury on the battlefield is virtually always associated with pain, it is paramount that the selected pain medication does not disrupt appropriate physiological mechanisms that are beneficial towards the maintenance of blood pressure and vital organ blood flow during that hemorrhagic insult. current guidelines for the selection of pain medications of a hemorrhaging soldier are based upon limited scientific evidence, with the vast majority of supporting studies being conducted on anesthetized animals. thus, the interaction between hemorrhagic shock and pain medications commonly employed on the battlefield is yet to be determined in the conscious humans. with this background, we will test the hypothesis that ketamine will impair the capacity for a conscious human to tolerate a hemorrhagic insult. the obtained data will provide the necessary scientific evidence in humans to support the committee on tactical combat casualty care (cotccc) guidelines on the analgesic of choice for moderate to severe injuries where the casualty is in hemorrhagic shock. notably, such data will identify the analgesic that least compromises a human's ability to tolerate a hemorrhagic insult, ultimately providing critical information to the combat medic on which analgesic should be employed for such an injury.

Eligibility criteria:
inclusion criteria: * 18-45 years of age * healthy * non-obese (body mass index less than 30 kg/m2) * body mass greater than or equal to 65 kg exclusion criteria: * subjects not in the defined age range * subjects who have cardiac, respiratory, neurological and/or metabolic illnesses * any known history of renal or hepatic insufficiency/disease * pregnancy or breast feeding * body mass less than 65 kg * current smokers, as well as individuals who regularly smoked within the past 3 years * positive urine drug screen * currently taking pain modifying medication(s)
us cycle control and blood pressure study

Conditions: Contraception

Summary: birth control patch study


Eligibility criteria:
inclusion criteria: * female subject requesting contraception * age: 18 - 45 years (inclusive); smokers must not be older than 35 years at the time of informed consent * normal cervical smear not requiring further follow-up (a cervical smear has to be taken at screening visit or a normal result has to be documented within the previous 6 months) * history of regular cyclic menstrual periods exclusion criteria: * pregnancy or lactation * significant skin reaction to transdermal preparations or sensitivity to surgical / medical tape * any disease that may worsen under hormonal treatment (cardiovascular, liver, metabolic) * use of other contraceptive methods than study medication

Keywords: pregnancy prevention female contraception patch
effects of plant-based polar lipids on acute and second meal glucose tolerance and appetite sensations

Conditions: Healthy Subjects; Diet Intervention

Summary: the overall goal of the project is to increase knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. more specifically the primary purpose is to evaluate effects on cardiometabolic test markers of bioactive compounds in healthy humans. previously the investigators reported beneficial effects of oat polar lipids on cardiometabolic risk markers. in this study the effects previously observed will be compared with cardiometabolic effects of another plant based lipid.


Eligibility criteria:
inclusion criteria: * apparently healthy men and women * non-smokers * between 20-40 years of age * bmi between 18,5-30 kg/m2 * no known metabolic disorders or food allergies. * the test subjects should follow a normal diet in accordance with the nordic nutrition recommendations. exclusion criteria: * fasting blood glucose ≥6.1 mmol/l * use of antibiotics or probiotics in the last three months or during the study period. * smoking * blood donation during the last two months and during the study. * food allergies or food intolerances * cvd * metabolic diseases * inflammatory bowel diseases.
tacking mesh versus self-fixating mesh for inguinal hernia repair

Conditions: Hernia, Inguinal

Summary: investigators are testing whether tacking mesh or self-fixating mesh used for inguinal hernia repair makes any difference in short-term pain or return to normal activities following the operation. other studies have shown no significant difference in hernia recurrence rate when metal tacks are not used to hold the mesh in place.

participants will be placed into two groups. one group of participants will have mesh tacked into place for their hernia repairs. the other group will have self-fixating mesh into place. both groups will have a piece of mesh that will widely cover the hernia defect. before surgery, the participant will be asked to rate discomfort on a 0-10 scale. zero stands for no pain and 10 is the worst pain they can imagine. investigators will record information about general medical condition, medications and activity level. during the operation information will be recorded about the pain medicines the participant may receive. in the recovery room the participant will be asked to rate their pain on the 0-10 scale and more information will be recorded about any additional pain medicines that they may receive and assess activity level. following surgery, investigators will contact the participants by survey to obtain more information about pain level, medication use, and activity level.

Eligibility criteria:
inclusion criteria: - all patients regardless of sex or age who were diagnosed with a inguinal hernia and underwent a totally extraperitoneal (tep) inguinal hernia repair at the mayo clinic in rochester, minnesota from june 2013 - june 2014. exclusion criteria: - patients who did not elect to undergo a hernia repair or who elected to undergo a different type of hernia repair instead of a tep procedure.

Keywords: mesh repair peritoneal
sound estimation and accuracy task

Conditions: Parkinson's; Alzheimer Disease

Summary: participants will be assigned to complete computerized estimation tasks for which there is a component of accuracy, such as estimating the duration of sounds. participants will be told that the task is used as an early diagnostic tool to detect those at risk for a medical condition (e.g., parkinson's disease, alzheimer's disease). instructions will be given to participants telling them that accuracy on the task is associated with the disease, whereas those who are not at risk of the disease tend to either overestimate or underestimate the duration of the sounds. the investigators examine whether such instructions about the purpose and diagnosticity of the tasks biases participants' responses to the tasks, leading them to purposefully be more inaccurate in their estimates.

participants will be assigned to complete computerized tasks for which there is a component of accuracy, such as estimating the length, in time, of sounds. participants will be told that the task is used as an early diagnostic tool to detect those at risk for a medical condition (e.g., parkinson's disease, alzheimer's disease). instructions will be given to participants telling them that accuracy on the task is associated with the disease in question, whereas those who are not at risk of the disease tend to either overestimate or underestimate the duration of the sounds. the investigators examine whether such instructions about the purpose and diagnosticity of the tasks biases participants' responses to the tasks. the investigators collect additional survey measures as statistical controls and potential explanatory variables for variation in the performance on the tasks, and also test whether financial incentives for accuracy on these tasks improve the accuracy of responses to these tasks. following the task, all participants will be told that the tasks used are actually not diagnostic of the diseases in question, and that deception was used to learn how people respond to instructions about how a task can be used for diagnostic purposes.

Eligibility criteria:
inclusion criteria: * 18 or older * able to access tasks on computer * able to hear sounds played on computer exclusion criteria: * computer speakers absent or not functioning

Keywords: diagnostic information risk perception