Kornimate/medical-research-clean huggingface dataset:
characterizing hiv-related diastolic dysfunction

Conditions: Heart Failure; HIV; Diastolic Dysfunction

Summary: this is a multicenter clinical trial of a cross section of hiv+ patients with and without diastolic dysfunction. approximately 200 haart-treated virally suppressed hiv+ subjects (100 hiv+/dd+ \& 100 hiv+/dd-) will be enrolled. this study will evaluate biomarkers, phenomapping, metabolomics, cmri, echocardiography to determine characteristics unique to this patient population.

with the advent of highly active antiretroviral therapy (haart), human immuno¬deficiency virus (hiv) type 1 infection has become a chronic disease. the proportion of patients expected to survive 5, 10, and 15 years after conversion in the haart era are 99%, 93% and 89% respectively. with increased life expectancy and decreased morbidity from opportunistic infections, the importance of chronic complications associated with hiv-1 infection, including hf is becoming more evident. the advent of haart has altered the epidemiology of hiv associated cardiomyopathy evolving from a primarily left ventricular systolic dysfunction to the growing recognition of left ventricular dd. dd is associated with the development of atrial fibrillation and heart failure (hf), and portends higher risk for all-cause mortality. thus there is a widespread prevalence of cardiac abnormalities in hiv infected individuals that are associated with hf development and may represent a sub-clinical abnormality that may be potentially intervened upon to reduce the risk of subsequent hf. there are little data to understand the natural history and pathogenesis of cardiac abnormalities, specifically dd in hiv+ individuals, which may adversely affect the longevity and quality of life of these individuals.

Eligibility criteria:
inclusion criteria: 1. age \>40 years 2. willingness and ability to provide informed consent 3. hiv antibody positive 4. on haart for \>6 months (hiv positive cohort only) 5. history of adequate viral suppression as defined by hiv rna level \<200 copies/ml in the past 6 months 6. lvef \>50% - exclusion criteria: 1. past ef \<50% 2. moderate or severe valve stenosis or regurgitation, or past repair or replacement 3. percutaneous or surgical revascularization or active angina 4. persistent atrial fibrillation 5. bp\>160mmhg sbp or \>100mmhg dbp 6. comorbid inflammatory disease (e.g. ra or sle) 7. active cancer or cancer chemotherapy treatment in the prior year (except skin cancer that did not require chemotherapy or radiation) 8. chronic use of steroids or anti-inflammatory therapy 9. gfr \<30 ml/min 10. active in a clinical trial with investigational product 11. pregnant or lactating females 12. contraindication to cmr or gadolinium injection (such as severe claustrophobia, metal implants, etc.)
efficacy of laser doppler flowmetry as a diagnostic tool in assessing revascularization of traumatised teeth

Conditions: Trauma; Diagnosis Dual

Summary: the aim of the study is to evaluate the efficacy of laser doppler flowmetry in determining the changes in the pulpal blood flow during the post-traumatic period of traumatised permanent teeth.

traumatic injuries of permanent teeth in children and adolescents are very common. the conventional pulp vitality tests are inaccurate and unreliable techniques in assessing the pulp vitality during the post-traumatic period, as well as during the immature teeth examination. the aim is to evaluate the efficacy of laser doppler flowmetry in determining the changes in the pulpal blood flow during the post-traumatic period of traumatised permanent teeth. the study is designed as a randomized, split-mouth, controlled clinical trial. the measurement of the blood flow of the dental pulp of both, traumatised and non-traumatised teeth, will be performed, using a laser doppler flow monitor, emission wavelength 785nm±10nm, dual-channel laser doppler monitoring option.

Eligibility criteria:
inclusion criteria: 1. fit and healthy subjects aged \< 18-year-old; 2. subjects with maxillary permanent incisor subjected to a traumatic injury without any dentoalveolar trauma involvement and have a contralateral homologous tooth with no signs/symptoms of injury; 3. subjects attended their first dental visit within 3 days of the dental trauma; 4. sensitivity value of the electric pulp test over 200 μa; 5. subjects with at least one vital and non-traumatised maxillary incisor acting as a control tooth; 6. ability to obtain a verbal acceptance from all the subjects to comply with all the treatments and follow-up timepoints attendance; 7. ability to obtain written informed consent by the patients' parents/guardians for treatment, participation in the study and publication exclusion criteria: 1. subjects who were undergoing therapy for neurological conditions or with mental or cognitive problems; 2. subjects who were taking sedative, analgesic, and/or anti-inflammatory medication 7 days prior to the treatment commencement; 3. subjects who have never had any first dental visit or treatment; 4. subjects with systemic diseases or physiological development delay; 5. subjects with active infectious diseases such as; influenza, scarlet fever, etc. 6. subjects with restorations covered more than half the labial surface of the investigated teeth.

Keywords: laser doppler flowmetry pulpal blood flow pulp vitality traumatised teeth paediatric dentistry
enhancing physical function in the long-term for older adults

Conditions: Weight Loss Maintenance

Summary: the intervention being studied is a 12-week nutrition and physical activity intervention, delivered using videoconference technology by registered dietitian clinicians to maintain weight loss and functional gains in older adults who successfully completed a weight loss intervention. the "legacy intervention" will include cognitive behavioral strategies (e.g., goal setting, self-monitoring, and social support), and draw upon a toolbox of e-approaches, including daily and weekly text reminders, virtual exercise classes, virtual individual and group nutrition classes, and step tracking device.


Eligibility criteria:
inclusion criteria: * participated in a weight loss intervention in the last 9 months and lost ≥ 3% body weight and improved sppb score by ≥ 1 point or 6mwt by ≥ 50 meters * age ≥ 60 * able to speak and understand spoken and written english. * able to record dietary intake and weight exclusion criteria: * presence of unstable or symptomatic life-threatening illness * neurological conditions causing functional impairment, including parkinson's disease, multiple sclerosis, and permanent disability due to stroke * inability to complete physical function assessment * no access to internet connection to participate in the tele-intervention * unable or unwilling to use provided tablet to participant in tele-intervention * history of cognitive impairment
a noninterventional, single-center feasibility study to evaluate measures of heart failure risk

Conditions: Heart Failure; Cardiomyopathy, Hypertrophic; Left Ventricular Hypertrophy

Summary: this is a non-invasive/observational study in healthy and mild hf subjects utilizing clinical and ambulatory measurements to improve detection, monitoring, and management of hf risks.


Eligibility criteria:
key inclusion criteria: * cohort 2: confirmed medical history of lvh based on american college of cardiology (acc)/american heart association (aha) guidelines and nyha class i at screening * cohort 3: confirmed medical history of hf consistent with current acc/aha guidelines and nyha class i at screening * cohort 4: confirmed medical history of hcm consistent with acc/aha guidelines and nyha class i or ii at screening key exclusion criteria: * active neurological disorder, such as uncontrolled seizure disorder. * current diagnosis of cancer or other known acute chronic infection, such as hepatitis b or hepatitis c, by medical history or an active infection requiring interventional therapy at screening. * shortness of breath, fatigue, heart palpitations, pain, or other limitations of physical activity
maintenance transcranial electrical stimulation for depression

Conditions: Major Depressive Disorder; Bipolar Disorder

Summary: transcranial electrical stimulation (tes) techniques offer a novel treatment approach for depression and have shown promising efficacy. however, there is no published data to date on their effectiveness as a maintenance treatment. this study will investigate ways of using tes as a maintenance treatment to prevent relapse in depression.


Eligibility criteria:
inclusion criteria: * all participants will be ≥ 18 years old. * participants must have experienced a significant clinical response, defined as ≥ 50% decrease from baseline scores on the montgomery asberg depression rating scale (madrs). exclusion criteria: * inadequate response to acute trial of tes. * suicidality. * clinically defined neurological disorder or insult. * metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites. * pregnancy (women of childbearing age will be asked to undergo a urine pregnancy test prior to starting the study). * concurrent long acting benzodiazepines, ritalin or dexamphetamine medication. * treatment for depression is changed during months 3-9 of the trial.

Keywords: depression treatment transcranial electrical stimulation maintenance
responders and quadripolar lv lead in crt

Conditions: Heart Failure

Summary: the purpose of this study is to observe the evolution of the crtd system with left quadripolar lead, in terms of electrical parameters in all pacing configurations and to evaluate the impact on the clinical outcome.

cardiac resynchronization therapy (crt) is limited by a high proportion of non-responders. pacing activation from proximal area with a left quadripolar lead might improve the depolarization pattern. to explore the effect of crt pacing on cardiac activity, the investigators will enroll approximately 180 patients who already underwent crt-d implantation with a quadripolar lv lead. after implant, as clinical practice, the device will be programmed with distal lv pacing configuration, after 6 months in patient non-responders to crt therapy the pacing configuration will be changed (proximal configuration). after 12 months in patients non-responders will be changed the pacing configuration again, choosing, if it is possible, a multi point pacing (pacing activation from multiple separated left ventricular (lv) sites).

Eligibility criteria:
inclusion criteria: * be in nyha ii, iii or iv functional class with approved standard indication by esc/ehra guidelines * successful quadripolar lv lead implant exclusion criteria: * less than 18 years of age * epicardial lead * life expectancy \< 12 months * pregnant or are planning to become pregnant during the duration of the investigation
intravesical epirubicin plus bcg to prevent the recurrence of transitional cell carcinoma of bladder

Conditions: Bladder Neoplasms

Summary: biochemotherapy (combined immunotherapeutic drugs and chemotherapeutic drugs) has shown virtue than that use chemical or biological drugs alone in the treatment of some malignant tumor. here we investigated the efficacy of sequential intravesical therapy with epi and bcg to epi or bcg alone in patients with transitional cell carcinoma of bladder cancer after surgical management.

methods from july 1996 to november 2003, a total of 138 cases of bladder cancer underwent turbt or partial cystectomy were entered the trail. they were divided into 3 groups randomly: 1, epi plus bcg; 2, use bcg alone; and 3, use epi alone. all the patients have been followed up for 28-40 months after surgery (average time was 36 months), and the frequency of bacterial, chemical cystitis and other local side effects were also observed.results after a median follow up of 36 months, the number of recurrences in group 1 was significantly reduced than group 2 and 3 (p\<0.05 vs group 2 and 3, x2-test). the frequency of bacterial, chemical cystitis and other local side effects was similar in group 1 and 2, whereas significant severe side effect was found in group 3 (p\<0.05 vs group 2 and 1, x2-test). allergic reactions, including skin rash, were more frequent in group 3, and other systemic effects were more frequent in group 1. conclusion biochemotherapy by single dose epi plus sequential bcg intravesical is markedly effect in preventing the recurrence of bladder cancer after surgical management. its side effects are low. this method is of high clinical value.

Eligibility criteria:
inclusion criteria: * primary single or multiple (more than 2 tumors) pta to pt1 transitional cell carcinoma, solitary or multiple grade ⅲ tumors and primary or concomitant carcinoma in situ of the bladder were included in the study exclusion criteria: * previous radiotherapy, intravesicial or systemic chemotherapy within 3 months of the study, presence of a second primary malignancy and transitional cell carcinoma of the upper urinary tract or prostatic urethra, invasion of periurethral prostatic ducts, prostatic gland or stroma were exclusion criteria

Keywords: bladder neoplasm; carcinoma; epirubicin; bcg; perfusion
mesothelioma avastin plus pemetrexed-cisplatin study

Conditions: Mesothelioma

Summary: our hypothesis is that the addition of bevacizumab to the standard chemotherapy treatment of mpm will improve overall survival and quality of life beyond that achieved with chemotherapy alone.

a phase ii trial associating the reference chemotherapy (pemetrexed plus cisplatin) with bevacizumab is needed to ensure that no specific toxicity is induced by this association, and that this triplet have interesting activity. as pleural mesothélioma is a rare tumor, a phase iii trial, using the survival data from the phase ii part study, will be able to include a sufficient number of patients, in a reasonable period of time, to answer the question of efficacy of the anti-angiogenic triplet, providing the efficacy outcomes could be considered as favorable, at the end of the phase ii part of the study.

Eligibility criteria:
inclusion criteria: * malignant, histologically proved, non resectable pleural mesothelioma * in case of pleural effusion, a talc pleurodesis, although not recommended, is allowed in accordance with current local practice, at the time of diagnostic thorascopy, with inclusion ct scan performed after pleurodesis. * ecog performance status 0-2 * mesothelioma with only pleural effusion without uni- or bidimensionally measurable disease will be eligible (adapted recist criteria) * at least 18 years of age, less than 76 years of age * radiation therapy of thoracocentis tract (3 x 7gy) performed before beginning medical study treatment, and the interval between thoracoscopic procedure and radiation will not exceed 28 days exclusion criteria: * prior chemotherapy * brain metastasis * history of cerebral vascular accident (cva) or transient ischemic attack
feasibility and preliminary efficacy of a web-based self-help program for college students

Conditions: Repetitive Negative Thinking

Summary: the goal of this pilot study is to test the feasibility and preliminary efficacy of the repetitive negative thinking (rnt) focused web-based self-help program in college students. the main questions it aims to answer are: * does the program work without any help of a clinician? * does the program have any reducing effect on the participants' rnt, depression, anxiety, stress and cognitive fusion scores? - does the program help participants to improve their psychological flexibility and committed actions? participants will be administered a set of questionnaires before and after completing the 10-day long web-based self-help program, provided on a daily basis. researchers will compare the intervention group with a waitlist control group to assess for any potential placebo effect.

after obtaining informed consent, all participants will receive a set of questionnaires for baseline measurement. participants will be randomized into two groups using block randomization: one as the intervention group and the other as the control group (waitlist condition). this method helps ensure an equal distribution of participants with similar characteristics in both groups, minimizing potential biases and increasing the validity of the study.

Eligibility criteria:
inclusion criteria: * having internet connection and a working smart phone or computer exclusion criteria: * having thoughts of self-harm or suicide, * diagnosed with psychotic disorder, * substance abuse * currently receiving psychological help

Keywords: acceptance and commitment therapy rumination
a tmu/nih integrated research project translation of basic research to clinical diagnosis and treatment of mild traumatic brain injury (mtbi)

Conditions: Traumatic Brain Injury

Summary: this integrated research project is cooperated by an fully-experienced team of taipei medical university and national institutes of health. we hope that we can find out the disease of balance, anxiety and sick headaches through the translation of basic research to clinical diagnosis and treatment of mild traumatic brain injury (mtbi).


Eligibility criteria:
inclusion criteria: * willing to accept this research * age above 17 years old * brain injury patients who are in glasgow coma scale(gcs) between 13 to 15 exclusion criteria: * age under 16 years old * serious brain injury patients * pregnant women * people who have accepted ears surgery once * uremia * liver cirrhosis

Keywords: minor traumatic brain injury translation
cardiac magnetic resonance in acute myocarditis

Conditions: Myocarditis

Summary: cardiac magnetic resonance (mr) is an established noninvasive diagnostic tool for detection of acute myocarditis. diagnosis of myocarditis at 1.5t is currently made with the help of the lake louise criteria (two of three criteria have to be positive in order to establish the diagnosis). although these criteria are accepted and widely used in clinical routine, several disadvantages exist. newer parameters like myocardial t1 and t2 mapping, extracellular volume fraction (ecv) and myocardial strain analysis have the potential to complement or even replace some of the lake louise criteria and further enhance the diagnostic performance of cardiac mr in patients suspected of having acute myocarditis. the aim of our study is to evaluate the diagnostic performance of a comprehensive cardiac mr protocol in patients with acute myocarditis.


Eligibility criteria:
inclusion criteria: * no past medical history of cardiac disease. * no cardiovascular risk factors (e.g. diabetes or hypertension) exclusion criteria: * contraindications for cardiac mr

Keywords: magnetic resonance imaging diagnostic imaging
effect of supplemental intake of omega-3 polyunsaturated fatty acids on the rate and complexity of spontaneously occurring ventricular and supraventricular arrhythmias in patients with implantable cardioverter defibrillator (icd) - a randomized clinical trial

Conditions: Coronary Artery Disease; Arrhythmia

Summary: we hypothesize that oral supplementation with omega-3 pufa will decrease occurrence of arrhythmic events among post-mi, icd recipients.

this is a randomized, placebo-controlled, crossover, double- blind interventional study. patients will receive 3.6 g of epa and dha fish oil and placebo oil for 6 months, randomly, in a crossover design, with a four month washout period between treatments. randomization will be stratified by ejection fraction (≤ 35% or \> 35%), and the type of the index arrhythmia (vt - spontaneous or inducible by electrophysiologic study (eps), versus other - vf, scd, primary prevention - madit ii). ischemia severity was chosen to be evaluated by single photon emission computed tomography (spect) during stress (dipyridamol infusion). subcutaneous adipose-tissue biopsy, a biomarker considered the gold-standard for the objective assessment of long-term habitual dietary intake of fish and marine omega-3 pufa (epa and dha) will be obtain. compliance will be monitored by counting returned capsules or bottles and by measuring the omega-3 pufa composition in red blood cells (rbc). three different types of questionnaires will be used in this trial to obtain more information as to the additional potential benefit of omega-3 pufa supplementation: 1. the newly israeli food frequency questionnaire (ffq) will be used to examine dietary intake of other nutritional habits/patterns and its relationship to the study outcomes. 2. the hebrew language sf-36 health survey will be used to examine general health status. 3. the back questionnaires will be use to examine possible beneficial effects of fish oil supplementation on depressive symptomatology.

Eligibility criteria:
inclusion criteria: * post-mi patients. * both single and dual chamber icd recipient. * implanted more than 3 months ago. * agree to give written informed consent. exclusion criteria: * less than 18 years of age. * icd implantation as a 'bridge' to heart transplantation. * stable antiarrhythmic medication over the last month prior to enrollment. * patients taking class i antiarrhythmic medication. * a projected lifespan less than one year. * participation in another trial (during or within 90 days before the study). * use of supplemental n-3 fatty acids during the last 3 months. * women who are pregnant and of childbearing potential who do not use adequate contraception. * patients known to have a history of recent drug or alcohol abuse. 10) history or current intestinal or hepatic disease.

Keywords: chd arrhythmia icd omega-3 pufa nutrition
whole-body electromyostimulation versus conventional low-volume strength training in overweight individuals

Conditions: Overweight and Obesity; Metabolic Syndrome

Summary: the main purpose of this study is to compare the effects of whole-body electromyostimulation versus a conventional low-volume strength-training program, each combined with an individualized, weight-reducing diet, on the cardiometabolic risk profile, muscle strength, body composition, inflammatory markers and subjective health outcomes in overweight individuals at increased cardiometabolic risk.


Eligibility criteria:
inclusion criteria: * body mass index \>25 * presence of at least 2 cardiometabolic risk factors exclusion criteria: * healthy persons or patients under age * overweight persons without any additional cardiometabolic risk factors * pregnancy, lactation * psychological disorders, epilepsy, sever neurological disorders * participation in other exercise- or nutrition studies within the last 6 months * acute cardiovascular disease * malignant disease * rheuma * intake of anabolic drugs, * skin injuries in the area of electrode placements * electronic implants (defibrillator, pacemaker) * persons in mental hospitals by order of authorities or jurisdiction

Keywords: exercise strength training health promotion inflammation body composition