Kornimate/medical-research-clean huggingface dataset:
online training for the reconstitution of fosun/biontech

Conditions: COVID-19

Summary: the covid-19 vaccine by biontech requires specific, delicate storage and dilution procedures to be stringently followed for safety and effectiveness. training should be completed prior to undertaking dilution procedures. currently, the nursing and pharmacy curricula do not have content on specialized vaccine reconstitution techniques. e-learning has become an essential component of teaching and learning due to covid. yet, optimal online learning module development for clinical procedural skill acquisition and appropriate online formative assessment has not been adequately explored. to bridge this training gap for hong kong nurses and pharmacists, this project aims to develop a video-based online learning programme, coupled to a randomized controlled study to determine the effectiveness of online vaccine reconstitution training. the module, a supplement to the current teaching curriculum, will train students from both nursing and pharmacy disciplines. outcome measures include formative assessment of student performance, which can be used to inform the design and content of experiential content in healthcare professional curriculums. if this learning platform is shown to be effective, the scope could be extended to other disciplines (not limited to healthcare) where learning complex procedural tasks are necessary for the absence of instructor-led teaching.


Eligibility criteria:
inclusion criteria: * students currently enrolled in the bachelor of pharmacy and bachelor of nursing programmes (years 1 to 4) at the university of hong kong exclusion criteria: * students not from the aforementioned programmes and years of study
a retrospective analysis of patients with full thickness wounds on a case by case basis

Conditions: Full Thickness Wounds

Summary: to demonstrate the effectiveness or ineffectiveness of novel treating agents or agents used for compassionate rescue, subjects and their wounds will be analyzed retrospectively and their non-identifiable information will be compiled in the form of case studies. subjects who demonstrated characteristics of interest (e.g. healing) as determined by the pi will be chosen for case studies.

all wounds at the southwest regional wound care center (wcc) are managed using anti-biofilm strategies. when determining the therapeutic course for a patient and his full thickness wound, all management agents that are available are considered for use; and the clinician uses his judgment to determine the most appropriate tools to use that will give the patient the most likely chance of success. some of the agents that are used are novel, and it is appropriate to demonstrate to others the potential usefulness of these agents

Eligibility criteria:
inclusion criteria: * male or female \> 18 years old * retrospective analysis

Keywords: full thickness wounds
axium coil in completing endovascular aneurysm surgery study

Conditions: Intracranial Aneurysm

Summary: the current observational evaluation is designed to evaluate the performance of the axium™ microfx™ detachable coil system for the treatment of intracranial aneurysms in the real life practice.

up to 25 patients from from us centers are anticipated to be enrolled for this evaluation. published literature on coils with electrolytic, thermal or hydraulic detachment will serve as the basis for control comparisons to the axium™ microfx™ detachable coil system for patients undergoing embolization of intracranial aneurysm. comparison will be based on criteria evaluating the safety of the procedure, the reliability of detachment, the occlusion stability and the packing density impact.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of one or more intracranial aneurysm, either ruptured or unruptured. * information on data collection provided to the patient or legally authorized representative and signed informed consent. * aneurysm diameter ≤10mm * age range of 18 - 90. exclusion criteria: * aneurysm previously treated. * aneurysm avm related or dissecting. * participation in a clinical investigation of other aneurysm treating or related devices. * any condition that would preclude the conduct of protocol follow-up. * aneurysm anatomy that is determined inappropriate for axium coil placement, prior to opening of an axium coil.

Keywords: patients presenting with an intracranial aneurysm
the feasibility study of recognition of cardiac arrest using a smart watch

Conditions: Cardiac Arrest

Summary: in this study, we want to find out whether the recognition of cardiac arrest using a smart watch is feasible or not. if this idea is possible, the recognition of cardiac arrest using the smart watch is easy and fast to the witness, like a general person. by using the smart watch, the emergency response system for cardiac arrest and the bystander cpr or bls is beginning earlier than using conventional cardiac arrest recognition method in field.

in korea, an out-of-hospital cardiac arrest (ohca) was occurred twenty thousand person per year, and among them sixty percent was occurred in their home. we already knew that a survivor rate and neurological outcome of ohca patient has a close relation with initial emergency management in field, like a bystander cardiopulmonary resuscitation (cpr), basic life support (bls), etc. however, in korea, a witness almost did not the bystander cpr or bls in field until highly trained rescuers arrived there. so, total survivor rate is just 2.4 % irrespective of neurologic outcome in korea. generally, in korea, a beginning of the bystander cpr progress throughout dispatcher's instruction of emergency response system. this system for ohca patient activate only when the witness recognize cardiac arrest and call the emergency response system. therefore, cardiac arrest recognition by the witness is very important. however, a conventional recognition of cardiac arrest in field is often difficult, because there are no monitoring devices, healthcare providers. the conventional recognition method of cardiac arrest is that it is firstly to check mental status, secondly check pulse on patient's carotid artery and self-respiration. this method is too difficult for the witness, especially general persons. even, it is difficult for an emergency physicians, too. consequentially, the recognition of cardiac arrest by the witness is generally delayed, a golden-time is running out until highly trained rescuers arrive there. an average arrival time of highly trained rescuers is eight to ten minutes. a hypoxic brain damage is begin from four minutes after cardiac arrest. as a result, this delayed time is already passed four minutes after cardiac arrest. so, the survivor rate and the neurologic outcome are not good enough. in this study, we want to find out whether the recognition of cardiac arrest using a smart watch is feasible or not. if this idea is possible, the recognition of cardiac arrest using the smart watch is easy and fast to the witness, like a general person. by using the smart watch, the emergency response system for cardiac arrest and the bystander cpr or bls is beginning earlier than using conventional cardiac arrest recognition method in field.

Eligibility criteria:
inclusion criteria: * over 18 years old * shock * cardiac arrest exclusion criteria: * pregnancy
trial of caffeine to alleviate dyspnea related to ticagrelor

Conditions: Dyspnea

Summary: ticagrelor treatment is associated with increased rates of dyspnea, where previous studies have implied a possible role of adenosine. the purpose of this study is to determine if the caffeine-antagonist is effective in reducing dyspnea related to ticagrelor.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * recent acute coronary syndrome with ongoing ticagrelor treatment * stabilized clinical condition with no plans of additional revascularization * dyspnea with onset after start of ticagrelor treatment * willingness to abstain from caffeine intake (e.g. coffee, tea, cola-type beverages; other foods, nutritional supplements or medications containing caffeine) for the duration of the study * provision of signed informed consent form exclusion criteria: * chronic obstructive pulmonary disease, asthma or other known pulmonary disease requiring daily medical therapy * obstructive sleep apnea syndrome requiring therapy * ongoing signs and symptoms of heart failure\*, or evidence of moderately to severely reduced left ventricular (lv) function * renal failure, glomerular filtration rate (gfr) \<30 or on dialysis * pregnancy or lactation * known allergy to ticagrelor, or caffeine, or known intolerance of caffeine * ongoing treatment with any of the following: quinolone antibiotics, fluvoxamine, phenylpropanolamine, carbamazepine, clozapine, lithium, non-steroidal anti-inflammatory drugs (nsaids); or any drug containing theophylline or caffeine. * any condition that seriously increases the risk of non-compliance or loss of follow-up
a consensus on opioid prescription for oncologic patients in latin america - a delphi study.

Conditions: Cancer Patients; Cancer-related Pain

Summary: as seen worldwide, cancer incidence is increasing in latin america achieving an amount of 1.3 million new cases annually.1 in addition, it is expected that up to 70% of patients with cancer will experience pain2, one of the most distressing symptoms in patients with advanced cancer. and despite of advances in cancer therapies, opioids remain the mainstay treatment of cancer-related moderate-to-severe and end-of-life pain.3 however, concerns regarding opioid prescriptions have emerged for reasons like the risk of misuse and the possibility of cancer progression. in the last decades, an increase in consumption of opioids as well as in opioids-related deaths generating the so called 'opioid crisis'. this rise is mainly due to abuse / addiction of opioids. consequently, oncologic patients are at risk for abuse, as well as for aberrant use, which can complicate the course of cancer treatment.4 5 another feature of opioids use in cancer patients is that it may contribute to disease progression. experimental studies suggest that opioids can may lead to immunosuppression and tumor progression or recurrence.6-8 on the other hand, retrospective analysis of clinical data shows conflicting results and trials are lacking.


Eligibility criteria:
inclusion criteria: * head of anesthesia, pain management and palliative care departments of cancer hospitals in latin america. exclusion criteria: * surveys not answered.

Keywords: opioids cancer-related pain end-of-life opioid abuse
diagnostic accuracy of ebv c promoter methylation kit in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: this clinical study aims to evaluate the diagnostic performance of a new epstein-barr virus (ebv) c promoter methylation detection kit. all participants will undergo a series of diagnostic tests including vca-iga, ebna1-iga, and ebv-dna assays. additionally, nasopharyngeal swabs will be analyzed for ebv c promoter methylation. confirmatory biopsy will be performed on all patients to establish a definitive diagnosis. this comprehensive approach seeks to assess the effectiveness of the methylation detection kit in a clinical setting.


Eligibility criteria:
inclusion criteria: participants who meet the following article 1 and also meet one of articles 2 to 6 can be enrolled: * understand, sign, and date the informed consent document to participate in the study * display one or more symptoms or signs indicative of nasopharyngeal carcinoma * test positive for ebv antibodies or ebv dna * be diagnosed with other head and neck carcinomas * be diagnosed with malignancies associated with ebv infection * require differential diagnosis from nasopharyngeal carcinoma during endoscopic or other imaging examinations * fulfill any additional conditions deemed appropriate by the investigator for inclusion in this study exclusion criteria: * have been diagnosed with nasopharyngeal carcinoma and have undergone treatment * experience relapse or metastasis of nasopharyngeal carcinoma following treatment * have unsuccessful nasopharyngeal swab collections * present any other conditions considered by the investigator as unsuitable for participation in this trial

Keywords: nasopharyngeal carcinoma diagnosis methylation detection epstein-barr virus
adaptive cognitive training on cognitive function in elderly diabetes patients in the community

Conditions: Cognition; Diabetes Mellitus, Type 2; Aging

Summary: objective a growing body of evidence supports diabetes as a risk factor for cognitive decline. diabetes is significantly associated with accelerated cognitive decline, poorer cognitive function, and mild cognitive impairment and dementia. cognitive training is an effective intervention to improve cognitive function. however, the current cognitive training does not fully consider the different areas and degrees of cognitive function impairment of older adults. this study aims to evaluate the effect of adaptive cognitive training on cognitive function of older adults with hypertension in the community. participants age 60 years or older, diagnosis of diabetes, fasting blood glucose≥6.1mmol/l and cognitive function assessment showed no dementia. design the study was designed as a double-blind randomized controlled trial. 120 diabetes participants without dementia aged 60 years or older in shijingshan, beijing were included. participants will be randomized to adaptive cognitive training (intervention group) and placebo cognitive training (control group) at a ratio of 1:1. both training will be delivered by using pads with the same appearance. the interventions will last for 6 months and follow up to 12 months, and both groups will be followed up on the same time schedules for all outcome measurements. the primary outcome is changes in moca scores from baseline to post-intervention, 6 months. the current trial has been reviewed by the ethics committee of plastic surgery hospital, chinese academy of medical sciences \& peking union medical college (approval number: 2024-162).


Eligibility criteria:
inclusion criteria: * with a clear diagnosis of diabetes (according to icd-10 or dsm-criteria), fasting blood glucose≥6.1mmol/l, maintaining the original diabetes treatment strategy * age ≥60 years old * literate and able to use smart phone or tablet computer skillfully, with caide dementia risk score \>9, but without a diagnosis of dementia (icd-10 or dsm-dementia diagnostic criteria) * have lived in the target community for at least 6 months and continue to live in the original community for the next 12 months exclusion criteria: * stroke or brain surgery in the previous 12 months * alcohol or drug abuse in the past 12 months * families, important people of participants in the study have concerns * live in the same household as a participant who has been randomly assigned * severe aphasia, physical disability, or any other factor that may prevent completion of neuropsychological testing * use of medications that may affect cognition, including sedatives, anxiolytics, hypnotics, nootropics, and cholinergic drugs; refusing or not receiving cognitive training * currently participating in another clinical trial.
atypical pneumonia

Conditions: Unresolving Pneumonia in Children

Summary: the goal of this observational study is to learn about causes of unresolved pneumonia in children who take appropriate antimicrobial therapy.

recurrent pneumonia is defined as two episodes of pneumonia in 1 year or three episodes over any time frame. non resolving pneumonias are characterized by the persistence of symptoms and roentgenographic abnormalities for more than 1 month. the key step in evaluating the patient referred for recurrent or persistent pneumonia is to review the clinical and radiographic features of the episodes to determine if there is adequate documentation to proceed with treatment. after deciding that a patient has had a persistent episode of pneumonia or the requisite number of recurrent episodes of pneumonia (accompanied by radiographic evidence of pulmonary infiltrates), it is essential to classify the episodes into those involving single or multiple lobes. on the basis of this classification.

Eligibility criteria:
inclusion criteria: * patients with incomplete resolution by 4 weeks despite appropriate antimicrobial therapy. * from the age of one month to the age of 6 years old. exclusion criteria: * \*age of the patient below one month and above 6 years old. * patients with chronic lung diseases. * patients with immunodeficiency. * patient with aspiration pneumonia.
study evaluating the safety and efficacy of tri-wire balloon for treatment of dysfunctional av fistula

Conditions: Arteriovenous Fistula

Summary: this prospective, multicenter, randomized, controlled study is designed to evaluate the safety and effectiveness of the tri-wire peripheral balloon dilatation catheter compared to a standard pta catheter in treating subjects presenting with clinical and hemodynamic abnormalities in native arteriovenous (av) fistulae located in the upper extremity.


Eligibility criteria:
inclusion criteria: 1. age≥18 years; 2. able to understand the purpose of the study, willing to participate and sign the informed consent, able and willing to accept the follow-up; 3. indications of percutaneous transluminal angioplasty for target lesion: target lesion shows \>50% narrowing relative to adjacent normal vein diameter by angiography or ultrasound with one of the indicators listed in kdoqi vascular access guideline 2019 update table 13.2. 4. reference vessel diameter of target lesion from 3.0 mm to 8.0 mm. 5. target lesion located from proximal to the anastomosis to the reflux vein at the distal end of the subclavian vein. 6. de novo or restenosis lesion. 7. single or tandem lesion, length of which ≤ 60mm. exclusion criteria: 1. women who are pregnant, nursing, or planning to become pregnant during the study. 2. patients who have accepted major surgeries within 30 days prior to the enrollment. (such as thoracic surgery, cranial surgery). 3. patients who plan to accept major surgeries within 30 days after the enrollment. (such as thoracic surgery, cranial surgery). 4. occlusion lesion or thrombosis. 5. infected fistula or severe systemic infection. 6. patients who suffer from central venous diseases. 7. patients known to be allergic or contraindicated to contrast agents. 8. patients who have participated in another clinical trial within 3 months prior to the study, or previous enrollment in this study. 9. subject has another medical condition, which, in the opinion of the investigator, may cause him/her to be noncompliant with the protocol or confound the data interpretation.
psychological distress during covid-19 pandemic

Conditions: Psychological Distress; COVID-19 Pandemic; Satisfaction

Summary: design, sample, and setting this is a cross-sectional study using an internet-based self-administered questionnaire of closed-ended questions and using convenience sampling. in total, 612 undergraduate students completed the survey in mansoura university. data collection data was collected anonymously through an online questionnaire created using the technology of google forms provided by google ™ and was constructed in arabic language. the questionnaire consisted of three sections. the first section assessed students' baseline characteristics including sex, age, area of study, academic level, residence, marital status, family members infected, close people infected, and knowing someone who died of the infection. the second section measured the psychosocial effects of covid-19 pandemic using two instruments, university of california los angeles (ucla) loneliness scale, version 324 and depression anxiety stress scale (dass-21).19 the ucla loneliness scale is a widely used self-report instrument of loneliness consisting of 20 items designed to measure both emotional as well as social loneliness. response of each item was rated on a four-point scale from (1) never to (4) always felt as expressed in each item. final score ranges from 20 to 80 with higher scores demonstrating higher feelings of loneliness. the scale's reliability was found to be high with alpha coefficients ranging from 0.89 to 0.94 for samples of students. the arabic version of ucla loneliness scale was used in the current study according to the arabic translation in egyptian culture by daswqee.20 the correlation coefficients values were 0.76 for females and 0.74 for males.

since december 2019, the novel coronavirus disease 2019 (covid-19) has spread from wuhan city to different areas in china and around the world. on 11 march 2020, the world health organization (who) declared the covid-19 outbreak a pandemic. on 14 february 2020, the egyptian ministry of health reported the first case of covid-19. to control the covid-19 outbreak, the egyptian government introduced preventive and containment measures with a partial closure starting on 25 march. on 31 march, egypt pronounced 710 covid-19 cases and 46 related deaths with a mortality rate of 6.48%. as on 06 june 2020, there were 1497 new cases with total cases of 32 612, a total of 1198 deaths and 8538 full recovery. generally, several potential stressors were caused by the pandemic that might lead to psychological distress and life dissatisfaction. individuals' overall assessments of their psychological wellbeing and quality of life are referred to as life satisfaction. psychological distress takes the shape of a negative emotion, which contrasts with life contentment. it refers to people's unfavorable emotional reactions to several stimuli, which might include tension, dread, worry and psychological instability.

Eligibility criteria:
inclusion criteria: - all available adults can fill in online surveys. exclusion criteria: - children under 18 years.

Keywords: psychosocial effects covid-19