Kornimate/medical-research-clean huggingface dataset:
mbsr on nocturnal hypertension

Conditions: Hypertension

Summary: objectives: to examine the feasibility and acceptability of treating nocturnal hypertension by mindfulness-based stress reduction program (mbsr). this will provide data essential for the main trial, which will also examine the definite effectiveness of mbsr to reduce nocturnal blood pressure (bp). hypothesis to be tested: mbsr and the current trial are acceptable and safe to patients with nocturnal hypertension; and future main trial is feasible in terms of recruitment, dropout rate and adherence to mbsr/bp measurements. design and subjects: this pilot randomized-controlled trial will recruit 76 patients with nocturnal ht (night-time systolic bp (sbp) during sleep 120 mmhg) and stage i hypertension (awake sbp = 135-159mmhg), as detected by ambulatory blood pressure monitoring (abpm). participants will be allocated in 1:1 ratio by stratified block randomization (by age and presence of mood disorder) to receive mbsr (intervention group) or usual care (control group) respectively. instruments: abpm/hbpm/mbsr patients' diary. interventions: the generic 8-week mbsr will be taught by a certified mbsr teacher. participants in mbsr arm will be asked to meditate 40 minutes every day during the interventional period. main outcome measures: rate of recruitment/dropout/adherence to mbsr/bp measurements data analysis and expected results: the rate of recruitment/dropout/adherence to mbsr/bp measurements will be presented. the acceptability of mbsr and the trial will also be assessed by patients' interviews. a high level of rate of recruitment, adherence to both mbsr and bp measurements and acceptability to mbsr are expected.


Eligibility criteria:
inclusion criteria: * diagnosed hypertension (ht) from clinical records (with or without anti-hypertensive medications) * nocturnal ht (night-time systolic blood pressure \[sbp\] during sleep ≥120 mmhg) and stage i hypertension (daytime sbp = 135-159 mmhg), as detected by 24-hour ambulatory blood pressure monitoring (abpm) * no change of dose and type of anti-hypertensive(s) in the prior 2 months exclusion criteria: * patients with atrial fibrillation (these patients have greater blood pressure variability) * daytime office systolic blood pressure (bp) ≥180 mmhg or diastolic bp ≥120 mmhg (regardless of nocturnal bp) * patients with known obstructive sleep apnoea * history of dementia or psychotic illnesses * patients with end-stage malignancies * nocturnal worker, because they will have a reverse bp pattern to other participants * patients receiving ≥3 bp medications at maximal tolerated doses * previous participation in structured mindfulness program(s) of ≥8 weeks or regular daily meditation practices * reported sleep time of \<4 hours per day * patients who do not agree to keep the same dose of anti-ht medications during the trial period * patients receiving anti-coagulants

Keywords: hypertension nocturnal hypertension mindfulness mbsr
endoscopic plantar fascia release in cases of chronic resistant plantar fasciopathy

Conditions: in Cases of Chronic Resistant Plantar Fasciopathy

Summary: the plantar fascia is a thick tissue band that connects the heel bone (the medial tubercle of the under surface of the calcaneus) to the metatarsophalangeal joints, forming the medial arch of the foot, which supports the foot during walking. irritation and scarring of the plantar fascia is one of the most common causes of heel pain . plantar fasciopathy accounts for 11% to 15% of all foot disorders in both athletes and sedentary patients . although commonly referred to using incorrect nomenclature as plantar fasciitis ,it is degenerative process (i.e. fasciopathy).the etiology of plantar fasciopathy is not clear. it can result from irritation due to overstrain of the fascia, which induces mucoid degeneration the pathologic ﬁndings include degenerative tissue changes without inﬂammatory mediators . the diagnosis of plantar fasciopathy is determined by the medical history and physical examination ﬁndings. typically, patients present with heel pain during weight bearing , especially in the early morning and with the ﬁrst steps after a period of inactivity . patients will usually have tenderness around the site of the plantar aponeurosis . the pain can be reproduced by stretching the diseased plantar aponeurosis by passive hyperextension of the metatarsophalangeal joints . endoscopic plantar fasciotomy is a relatively new procedure, involves an endoscopic approach to the heel, allowing a plantar aponeurosis release to be performed with delicate instruments, minimal dissection, and immediate weight bearing


Eligibility criteria:
inclusion criteria: * adults more than 18 years old presented by a single site heel pain with local pressure at the origin of plantar fascia on the medial calcaneal tuberosity for one year, with failure of at least two lines of conservative treatment including: non-steroidal anti-inflammatory drugs (nsaids), corticosteroid injections, physical therapy, exercise program (achilles tendon and plantar fascia stretching exercises) and orthotic devices (heel cup, molded shoe insert or night splint) for at least 3 months. exclusion criteria: * patients younger than 18 years. * patients who had a local infection or a metabolic disorder especially diabetes, generalized polyarthritis, sero-negative arthropathy, , tarsal tunnel syndrome. * patients with congenital anomalies e.g pesplanus, pescavus, limb length discrepancy, in-toeing, neuro-muscular disorders. * patients with an ipsilateral or contralateral vascular or neurological abnormalities, or malignancies. * recent trauma or foot and ankle deformity or fractures. * active anticoagulation therapy or bleeding disorders * patients who received a corticosteroid injection within the previous four weeks.
carbohydrate quality and its impact on athletic enjoyment and burnout

Conditions: Athlete

Summary: this study aimed to evaluate the effect of carbohydrate quality on enjoyment of physical activity and burnout in athletes. data were collected from 139 active athletes aged 19 to 35 years using a demographic structure questionnaire, the athlete burnout questionnaire (abq), and the physical activity enjoyment scale (paces). carbohydrate quality was assessed using food frequency data, and the results were analyzed with spss 24 software.

objective: the aim of this study was to evaluate the effect of carbohydrate quality on enjoyment of physical activity and burnout in athletes. method: a total of 139 active athletes aged 19 to 35 years participated in the study. participants completed a demographic structure questionnaire, the athlete burnout questionnaire (abq), and the physical activity enjoyment scale (paces). to assess carbohydrate quality, food frequency data were collected, and scores were based on fiber intake, the whole-to-total grain ratio, glycemic index, and solid-to-total carbohydrate ratio, each evaluated on a scale from 1 to 5 points. the resulting scores were categorized into five quartiles, with q5 indicating the highest and q1 the lowest carbohydrate quality. data were analyzed using spss 24 software.

Eligibility criteria:
inclusion criteria: * only athletes who are actively participating in sports * age range of 19 to 35 years * voluntary participation exclusion criteria: -individuals engaging in irregular physical activity

Keywords: carbohydrate quality sport physical activity burnout
growwell - responsive bottle feeding

Conditions: Bottle Feeding

Summary: the overall goal of this research is use digital health to augment the clinical encounter with women, infants, and children (wic) clinicians and prevent rapid infant weight gain among children living in low-income households. intervening on weight gain during infancy offers an opportunity to influence lifelong obesity risk. using personalized motivational messages and targeted skills-training resources, the intervention will support parents and caregivers in adopting responsive feeding strategies. knowledge gained from this project will be used to develop a future, larger grant submission focused on developing healthy feeding and eating habits among mother-infant dyads.

assess the feasibility and acceptability of a digital intervention aimed at increasing responsive infant feeding behaviors, beginning 1 month postpartum and continuing through 3-months postpartum, among a prospective cohort of women receiving wic benefits. use qualitative methods to explore barriers and facilitators to participation in a digital infant feeding intervention among women receiving wic benefits during early postpartum

Eligibility criteria:
inclusion criteria: * aged ≥18 years * as a smartphone and an email address * willing to send and receive daily text messages * can read and write in english * child is \<=6 weeks exclusion criteria: * participating in in a different research study that, in the opinion of the investigator, would conflict or would otherwise be too problematic if the subject were to participate in this study * planning to leave north carolina in the next 6 months * subjects who do not have the capacity to give legally effective consent * any medical or congenital condition that would interfere with infant feeding or growth (ie, down syndrome or cleft lip or palate)

Keywords: obesity prevention women, infants, and children )wic) infant growth
a study in postoperative pancreatic fistula

Conditions: Pancreatic Cancer

Summary: the international study group of pancreatic surgery (isgps) issued the definition and classification system of postoperative pancreatic fistula (popf), and received widespread recognition. currently, it has become an important reference for clinical treatment of popf.

the definition of popf released by isgps in 2016 still seems to have certain deficiency. for example, in both definitions in 2005 and 2016, the re-operation is used as an important judgment index of "grade c popf". but a unified standard or consensus is still lacked for the indication of popf re-operation, which may finally impact the diagnosis of "grade c popf". therefore, we performed this study, so as to better improve the relevant definition and provide guidance for the diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * must have a diagnosis of popf; * aged 18 or older; * of either sex. exclusion criteria: * no specific exclusion criteria will be applied to a participant as long as the participant is eligible for the trial.

Keywords: popf classification system
national early warning score and d-dimer to identify medical patients at low risk of 30-day mortality

Conditions: Medical Patients in the Emergency Department

Summary: the aim is to determine if the national early warning score combined with plasma d-dimer levels can be used in risk stratification of acutely ill medical patients presenting to a danish emergency department. the investigators wish to identify patients at low risk of mortality within 30 days.

large increases in emergency admissions are raising concerns about whether all admissions are necessary. if there was a fast and reliable system that could be used to determine the risk of all medical patients, many low-risk patients could be safely returned to primary care or outpatient follow-up clinics. the investigators wish to determine, if the combination of the national early warning score and plasma d-dimer levels can be used to identify patients at low risk of mortality within 30 days in an unselected group of medical patients presenting to a danish emergency department. this is a prospective observational study that will be performed on adult medical patients referred to the emergency department of a danish hospital to be assessed for possible admission. the study will be performed in the emergency department of hospital of south west jutland in the region of southern denmark.

Eligibility criteria:
inclusion criteria: * admission to the emergency department of hospital of south west jutland * requirement of any blood test * age 18 years * informed consent given exclusion criteria: * age 18 years * informed consent not given

Keywords: emergency department medical patients d-dimer national early warning score news 30-days mortality mortality
voiding assessment based on minimum spontaneous void of 150 ml compared to retrograde fill method after female pelvic floor reconstructive surgery

Conditions: Urinary Incontinence; Pelvic Organ Prolapse

Summary: this study will compare voiding assessment based on a minimum spontaneous voided volume of 150 cc with the standard retrograde fill approach in women after pelvic floor procedures.


Eligibility criteria:
inclusion criteria: * all 18-year-old or older women who undergo surgery for urinary incontinence and/or pelvic organ prolapse (pop) exclusion criteria: * patients who require prolonged foley catheter or suprapubic catheter
a study of blyg8824a in participants with locally advanced or metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: this study will evaluate the safety, tolerability, and pharmacokinetics of blyg8824a and will make a preliminary assessment of the anti-tumor activity of blyg8824a in patients with locally advanced or metastatic colorectal cancer.


Eligibility criteria:
inclusion criteria: * ecog performance status of 0 or 1 * life expectancy of at least 12 weeks * histologically or cytologically documented invasive crc: incurable, unresectable, locally advanced or metastatic crc previously treated with multimodality therapy or mcrc * locally advanced or metastatic crc that has relapsed or is refractory to established therapies * prior disease progression (or intolerance) following oxaliplatin, irinotecan, fluoropyrimidines, and anti-egfr monoclonal antibodies * an archival tissue specimen or fresh baseline biopsy (when archival is not available) is required for enrollment into the study * measurable disease, according to the response evaluation criteria in solid tumors (recist) v1.1. non-measurable evaluable disease is acceptable for dose-escalation. * adequate hematologic and end organ function * acute, clinically significant treatment-related toxicity from prior therapy resolved to grade ≤ 1 prior to study entry expansion cohort-specific inclusion criteria * mss or msi-l disease as determined by polymerase chain reaction (pcr) and/or ihc * measurable disease by recist v1.1 with at least one measurable target lesion in the expansion cohort * progression must have occurred during or after most recent treatment for locally advanced or metastatic colorectal cancer * for patients enrolled in either a dedicated biopsy cohort or other expansion cohorts where biopsy is clinically feasible, willingness to consent to mandatory fresh pretreatment and on-treatment biopsies of safely accessible tumor lesions exclusion criteria: * pregnant or breastfeeding, or intending to become pregnant during the study or within 4 months after the final dose of blyg8824a * significant cardiopulmonary dysfunction * known clinically significant liver disease * positive serologic or pcr test results for acute or chronic hbv infection * acute or chronic hcv infection * hiv seropositivity * poorly controlled type 2 diabetes mellitus * current treatment with medications that are well known to prolong the qt interval * primary cns malignancy, untreated cns metastases, or active cns metastases * leptomeningeal disease * spinal cord compression that has not been definitively treated with surgery and/or radiation * history of autoimmune disease * prior allogeneic stem cell or solid organ transplantation
comparing visual outcomes in matched patients receiving a low cylinder power toric iol or a non-toric iol

Conditions: Cataract and IOL Surgery

Summary: the purpose of the study is to determine if visual function is improved with implantation of a low-cylinder toric intraocular lens, relative to a non-toric intraocular lens.

the clareon(r) t2 iol and the clareon (r) non-toric iol will be randomly implanted in subjects determined to be appropriate for the t2 iol. visual acuity, low contrast acuity and contrast sensitivity will be measured 3 months postoperatively.

Eligibility criteria:
inclusion criteria: * candidate for cataract surgery, suitable for implantation with a low cylinder toric iol exclusion criteria: * pathology that would confound outcomes, previous ocular surgery

Keywords: toric iol
treatment trial of thermoregulatory disturbances in adolescent anorexia nervosa patients with either ginger powder footbaths or warm water footbaths

Conditions: Adolescent Anorexia Nervosa

Summary: a study to explore whether warm water footbaths with added ginger powder can improve thermoregulatory processes in adolescent anorexia nervosa patients and provide them with an increase in subjective feeling of warmth. the participants will receive a warm footbath four times a week for six weeks with a physiological and psychological testing point once before the beginning of the six-week footbath period and once after.

this is a two-arm randomized controlled trial to evaluate the efficacy of warm water footbaths with added ginger powder (experimental) compared to warm water only footbaths (control) in adolescent anorexia nervosa patients. participants will receive footbaths 4 times per week before bed-time over a period of six weeks.the main focus is on subjective increase in overall body warmth. moreover, core body temperature, skin temperature at the extremities and several psychological as well as physiological scores and parameters are assessed before and after the six-week intervention. a follow-up is planned at six months post intervention, where core body temperature, physiological and psychological parameters are once more tested.

Eligibility criteria:
inclusion criteria: * main diagnosis: anorexia nervosa * written informed consent of participants and legal guardians exclusion criteria: * other eating disorder diagnosis apart from anorexia nervosa * known allergic reaction to ginger

Keywords: anorexia footbath ginger powder thermogenic substances thermoregulation external applications anthroposophic medicine eating disorders
in-depth characterization of atriogenic secondary tricuspid regurgitation due to atrial fibrillation

Conditions: Heart Valve Incompetence; Atrial Fibrillation, Persistent

Summary: 1050 patients with persistent/permanent atrial fibrillation (af) will be studied using conventional and advanced (three-dimensional and deformation imaging) echocardiography. patients with moderate/severe isolated secondary tricuspid regurgitation (str) will undergo blood tests to assess their proteomic profile and cardiac ct to measure the tricuspid annulus geometry. the project will aim to 1. assess the prevalence of moderate/severe isolated str in patients with af; 2. identify the mechanisms associated with the development of moderate-severe str in patients with af; 3. identify the proteomic profile associated with significant growth of tricuspid valve leaflets as a mechanism to protect patients with af from the development of moderate/severe str; 4. evaluate the effects of the restoration of sinus rhythm on the severity of str and the remodeling of the right heart cardiac structures (i.e. right ventricle, right atrium, and tricuspid valve apparatus).


Eligibility criteria:
inclusion criteria: * age\> 18 years * persistent/permanent atrial fibrillation * good acoustic apical window * left ventricular ejection fraction \> 50% * pulmonary artery systolic pressure\< 50 mm hg * no more than mild mitral or aortic valve disease * ability to attend clinical and echocardiographic follow-ups * signature of the study informed consent exclusion criteria: * pregnancy * implanted pace-maker or icd * previous heart valve surgery or transcatheter treatment * previous heart transplant * organic tricuspid regurgitation

Keywords: functional tricuspid regurgitation three-dimensional echocardiography doppler echocardiography right ventricular function atrial fibrillation
dual energy ct urography with reduced iodinated contrast

Conditions: Aortic Aneurysm

Summary: the goal of this study is to validate that dual energy ct (dect) urography when performed with a 50% reduction in iodinated contrast dose results in a ct exam with equal or better image quality and equal or better diagnostic capability compared to traditional single energy ct (sect) performed with a standard contrast dose.

the investigators hypothesize that dect urography performed with a 50% iodine dose reduction is equivalent to sect urography performed with a full iodine dose for: * enhancement of the aorta, renal arteries, and renal veins * enhancement of the renal cortex * enhancement of the renal pelvis, ureters, and bladder * subjective evaluation of image quality * objective evaluation of image quality in addition, the investigators hypothesize that dect virtual non-contrast images using material suppression from the same low iodine ct exam results in equivalent diagnostic information compared to sect true non-contrast images obtained in the same patient during the same exam. if the true non-contrast images could be replaced by the virtual non-contrast images without loss of information, there is potential for dect to both significantly lower radiation dose as well as significantly decreasing iodine dose. the investigators designed this research protocol to prospectively test these hypotheses in a population scanned with a 50% reduced iodine dect urography protocol compared to a control population scanned with a standard iodine dose clinical sect urography protocol.

Eligibility criteria:
inclusion criteria: * age \>50 * outpatient scheduled to have a ct urography at the site exclusion criteria: * severe allergy to iodine containing contrast * pregnancy (which is very unlikely for those over 50) * body mass index (bmi) over 35 kg/m2 * inability to provide informed consent * inpatient
use of the camouflage syringe to reduce dental anxiety and fear in children

Conditions: Anxiety; Fear

Summary: dental fear and anxiety in children constitue a crucial challenge to dental care delivery as well as future behavior related to dental problems in children. a common cause of such anxiety and fear is the procedural intervention that uses needles and syringes since a visual impact due to the needle acts as a deterrent to the child's cooperation during dental procedures. we therefore improvised the syringe such that it will camouflage the needle. we hypothesized that the use of this needle will alleviate the child's anxiety and therefore will demonstrate improved outcomes related to pain, fear and anxiety. this study is a group randomized trial to test the efficacy of the camouflage syringe as compared to the conventional syringe in children.

the present study was conducted with an aim to evaluate the efficacy of a needle-covering camouflage syringe as compared to the conventional syringe in reducing dental anxiety and fear in children. the study was carried out in 100 children who consecutively reported to the study center and were allocated to the camouflage syringe arm or conventional syringe arm using block randomization to ensure equal distribution across trial arms. the study assessed the degree of dental anxiety and fear using venham's clinical rating scale in conjunction with rating scale for movement, crying and overall behavior and venham's picture test. the study also assessed parental emotional stress status when the child underwent the injection procedure and the reaction of the child after going home by parental emotional stress questionnaire and recall questionnaire, respectively. the study used appropriate statistical methods to determine the efficacy of the camouflage syringe in reducing the anxiety and fear.

Eligibility criteria:
inclusion criteria: * children reporting to study center with dental problems * dental procedure requiring local anesthesia * informed consent from the parents exclusion criteria: * mentally challenged children * medical problems negating use of local anesthesia and/or surgical intervention