Kornimate/medical-research-clean huggingface dataset:
drug-eluting balloon in acute myocardial infarction

Conditions: Coronary Artery Disease; Atherosclerosis; Thrombosis; Acute Myocardial Infarction

Summary: the investigators hypothesize that patients with acute st elevation myocardial infarction may benefit from primary angioplasty with use of a drug eluting balloon/bare metal stent combination without impairing the process of normal vascular healing and endothelial function. the goals of this study are: 1. to compare 6-month angiographic outcome after primary angioplasty using drug eluting balloon/bare metal stent combination versus drug eluting stent versus bare metal stent. 2. to compare stent apposition and stent endothelialization after primary angioplasty using drug eluting balloon/bare metal stent versus drug eluting stent versus bare metal stent. 3. to compare coronary endothelial function after primary angioplasty using drug eluting balloon/bare metal stent versus drug eluting stent versus bare metal stent.


Eligibility criteria:
inclusion criteria: * stemi within 12 hours of onset of complaints * candidate for primary pci with stent-implantation * successful thrombus aspiration defined by no angiographic signs of thrombus a the site of plaque rupture and timi flow more or equal 1 exclusion criteria: * unable to give written informed consent * diabetes and type c- coronary lesion * previous pci or cabg of infarct related vessel * left main stenosis more than 50%. * triple vessel disease with stenosis more than 50% in 3 epicardial coronary arteries * target vessel reference diameter less than 2.5 and more than 4.0 mm * target lesion length more than 25 mm * intolerance for aspirin or clopidogrel * life expectancy less than 12 months * women with child bearing potential
fitness and daily function in adults

Conditions: Cardiovascular Disease

Summary: the purpose of this study is to examine the impact of aerobic fitness on the ability of able and disabled older adults to perform daily functional activities. subjects are tested in their oxygen use patterns as they perform a series of functional tasks (such as walking on stairs) and following a 24-week training program focused on improving the ability to perform daily tasks likely requiring aerobic fitness (such as walking on stairs).


Eligibility criteria:
both healthy and self-reported mobility-impaired older adults

Keywords: rehabilitation exercise test aging
lumbar plexus and suprainguinal fascia iliaca blocks for total hip replacement

Conditions: Hip Osteoarthritis; Pain, Acute; Pain, Postoperative; Opioid Use

Summary: the nerves from lumbar plexus (lp) are the current target to achieve analgesia after a total hip arthroplasty (tha). lumbar plexus block (lpb) is an alternative that provides optimal postoperative analgesia. however, many adverse effects and complications have been reported due to its proximity to vital structures. because of these shortcomings, an alternative to block the lp nerves is required. in a recent trial suprainguinal fascia iliaca block (sfib) was reported to provide reliable analgesia in tha. sfib may carry a lower risk profile, however, no study has compared the efficacy of lpb and sfib in this setting. thus, this randomized trial is set out to compare us guided lpb and sfib for analgesia after tha. the hypothesis is that both blocks would result in similar postoperative opioid (morphine) consumption at 24 hours and, therefore, designed the study as an equivalence trial.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * american society of anesthesiologists classification 1-3 * body mass index between 20 and 35 (kg/m2) exclusion criteria: * adults who are unable to give their own consent * pre-existing neuropathy (assessed by history and physical examination) * coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets ≤ 100, international normalized ratio ≥ 1.4 or prothrombin time ≥ 50) * renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine ≥ 100) * hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases ≥ 100) * allergy to local anesthetics (las) or morphine * pregnancy * prior surgery in the corresponding side of the lumbar o suprainguinal area * chronic pain syndromes requiring opioid intake at home

Keywords: nerve block fascia iliaca hip replacement lumbar plexus
insulin detemir compared to insulin glargine: appetite and calories consumed in type 1 diabetes

Conditions: Diabetes Mellitus

Summary: patients with diabetes treated with insulin often gain weight, which may deter patients from adhering to insulin treatment. detemir is one type of long acting insulin approved by the food and drug administration for use in people with diabetes. it is similar to other long acting insulins (neutral protein hagedorn \[nph\], glargine) except that it has been associated with less weight gain compared to other types of insulin. the reasons for this are still unclear. one possibility is that detemir insulin acts differently than do other insulins in affecting how diabetic patients eat meals. the purpose of this study is to determine whether appetite and calories eaten during a meal are affected by the type of insulin used to treat diabetes. this is a pilot study which means we are gathering preliminary information to determine if a larger study can be done.

insulin detemir is a neutral, soluble long acting insulin analog with weight neutral properties. in limited studies, it has been shown to result in less weight gain in type 1 and type 2 diabetics compared with other long acting insulin formations. a possible mechanism for its weight neutrality is the fatty acid chain that may allow for improved central nervous system activity and effects on satiety. the primary objective of this study is to determine if patients with type 1 diabetes consume fewer calories when allowed to eat to satiety while treated with insulin detemir compared to insulin glargine. secondary objectives are 1) subject responses on validated satiety scales and food diaries, 2) bioelectrical impedance analysis, 3) resting energy expenditure on indirect calorimetry/metabolic cart measurement, and 4) centrally acting mediators of satiety measured in the serum (peptide yy \[pyy\], ghrelin, leptin).

Eligibility criteria:
inclusion criteria: * type 1 diabetes * treated with long-acting and meal time insulin therapy for at least 2 years * ages 18 to 60 years of age * glycosylated hemoglobin value between 7 - 9 mg/dl * c-peptide value less than 1.0 pmol/ml 90 minutes after oral boost plus administration. exclusion criteria: * advanced complications of diabetes (nephropathy, retinopathy, significant neuropathy, coronary artery disease) * severe medical illness or medical conditions including congestive heart failure, angina, liver failure or renal failure * pregnancy * alcohol or drug abuse or dependence within three months of study entry * less than 50 % agreement on 50-item food questionnaire with the food array "buffet style" study meal. * women of child-bearing age not adhering to the following contraceptive methods: oral contraceptives, barrier methods including condoms or diaphragm, or abstinence.

Keywords: diabetes insulin dependent diabetes diabetes mellitus detemir levemir glargine lantus insulin appetite satiety centrally acting mediators of satiety three factor eating questionnaire pyy ghrelin leptin
impact of regular consumption of grapes on eye health in singapore older adults

Conditions: Eye Health; Age-related Macular Degeneration

Summary: aging epidemics in singapore are rapidly increasing and age-related macular degeneration (amd) prevalence is significantly associated with older age. this study aims to understand the effect of consuming freeze-dried table grape powder on amd in an older population.

this will be carried out through a 16-week double-blind, randomized, placebo-controlled trial of parallel study design. thirty-eight men and women (aged between 60 and 85 years old inclusive) will recruited and assigned to an intervention or placebo group. the intervention group will consume 46 g/day of a freeze-dried table grape and the control group will consume the same amount of a placebo, table grape placebo powder. measurements of 1) macular pigment optical density (mpod), a clinical marker for eye health, 2) carotenoids status, 3) markers of oxidative stress, 4) markers of endothelial function, 5) body size and blood pressure, and 6) dietary assessment will be assessed over the 16-week study. this study will consist of 1 screening visit and 5 study visits in 4-week intervals to the food science and technology department, occupational health clinic and national university heart centre.

Eligibility criteria:
inclusion criteria: * male and female participants, aged between 60 and 85 years old inclusive * able to give informed consent in english exclusion criteria: * smokers * allergy to grapes * known eye diseases (macular degeneration, cataracts, retinopathy or glaucoma), blindness in at least one eye or have had eye surgery * abnormal kidney and liver function * taking eye medication and/or dietary supplements for the eyes for the past 3 months * taking supplements containing carotenoids (e.g. vitamin a, lutein, zeaxanthin) for the past 3 months * currently on type 2 diabetic medication. * currently on anti-hypertensive or cholesterol-lowering; unless this prescription has been ongoing for more than 3 years prior to study participation. * currently on a specialized diet (e.g. vegetarian, vegan, weight loss diet, low fat diet) * consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider or 45ml of distilled spirit. * significant change in weight (≥ 3 kg body weight) in the past 3 months * significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week * poor peripheral venous access based on past experiences with blood draw * participating in another clinical study

Keywords: eye health age-related macular degeneration carotenoids
effect of dopaminergic medication on recovery of aphasia

Conditions: Aphasia

Summary: the investigators have been offering computer assisted therapy of aphasia (cat) as a complement to traditional treatments to aphasia patients of the "service of neurorehabilitation" for some years. the investigators have shown its efficacy in hospitalised patients with recently acquired aphasia. in addition to studies stressing the importance of treatment intensity, several studies suggest that pharmacological treatment can also improve recovery after a cerebral lesion. the underlying idea is that the administration of medication influencing the system of neurotransmitters can play a role in functional recovery. studies have assessed mainly substances acting on the dopaminergic (amphetamine and bromocriptine) and gabaergic system (piracetam). the main objective of the present study concerns the evaluation of the effects of levodopa on recovery of anomia in patients with aphasia. in particular, the investigators use cat to control intensity and quality of therapy and they will assess whether the administration of levodopa promotes recovery. in each patient, two periods of anomia therapy with cat, each performed with a different word list, will be compared. in addition to speech therapy, each period will be associated with the administration of either levodopa and benserazide (madopar ®), or placebo. evaluations at baseline and after each treatment period will be performed with the material and denomination battery


Eligibility criteria:
inclusion criteria: * patient with aphasia hospitalised at the "service of neurorehabilitation" with presence of anomia absence of comprehension deficits, absence of executive or apraxic dysfunctions that might impede the handling of keyboard or mouse, absence of stereotypies or perseverations dominating the aphasic symptoms. exclusion criteria: * patients who do not have their ability to judge or who suffer from parkinson's syndrome requiring dopaminergic treatment will be excluded. moreover, absolute medical contraindications for the medication will be respected: known hypersensitivity to one of the components, patients taking mao inhibitors or sympathomimetics, severe hormonal, renal, hepatic, or cardiac affections, pregnancy or breastfeeding, women at reproductive age without reliable contraception, angle closure glaucoma, psychosis or severe neurosis, age \< 25 years, malign melanoma, or planned anesthesia during the study period + 48 hours.

Keywords: treatment of anomia levodopa patient with aphasia hospitalised at the "service de neurorehabilitation" with presence of anomia
high dose and low dose of atorvastatin in patients with unstable angina and nstemi (non st elevation mi)

Conditions: Cardiovascular Disease

Summary: the aim of this study is to compare the effect of high dose and low dose of atorvastatin in reduction level of c-reactive protein (crp) in patients with unstable angina and nstemi (non st elevation mi) attending shahid mohammadi hospital in bandar abbas.

this study compare the effect of 80mg atorvastatin followed by two 20mg daily atorvastatin with three 80mg daily atorvastatin in reduction of crp in patients with unstable angina and nstemi (non st elevation mi) attending shahid mohammadi hospital in bandar abbas in 2009.

Eligibility criteria:
inclusion criteria: * patients with unstable angina with chest discomfort at rest with normal ekg or st depression (at least 0.1mv) in two consecutive leads or new and deep t inversion (at least 0.2mv) exclusion criteria: * myocardial infarction with st elevation * diabetes mellitus * previous statin use * current infectious disease

Keywords: unstable angina nstmi statin atorvastatin
"anticipatory guidance in the nursery and its impact on non-urgent emergency department visits"

Conditions: Health Knowledge, Attitudes, Practice; Sneezing; Constipation; Nasal Congestion and Inflammations

Summary: kennedy et al, in a study of pediatric emergency department (ed) use by newborns less than 14 days of age, revealed that half of all visits in this population were non-acute problems. other pediatric ed utilization studies have shown similar findings in that 32% to 72% of all visits were for non-urgent problems. many studies have found that primiparity and young maternal age are associated with non-acute ed presentations. a recent factor that has been investigated is the effect of early neonatal discharge. some other factors are nonwhite mothers and mothers on medicaid. zandieh et al, found additional predisposing determinants for non-urgent ed visits, such as single parenthood, hispanic ethnicity, and having perceptions that their child's overall physical health was poor. paradis et al found that parents receiving a video intervention rated higher confidence with specific infant care skills and reported feeling better prepared to care for their baby, compared to parents receiving only handouts. however, there isn't any reported study that evaluates the benefits of receiving both, a video intervention along with handouts. aim: to demonstrate whether conducting anticipatory guidance related to non-urgent problems will reduce non-urgent ed visits, compared to care as usual (cau) anticipatory guidance (sudden infant death syndrome and shaken baby syndrome videos; and unstructured talk about jaundice, vaccinations, appointments, care of umbilical stump, normal urination and bowel movement, fever).

inclusion criteria: mother of a newborn in the well baby nursery (wbn) of bronx-lebanon hospital center during the 4-month recruitment period of the study. exclusion criteria: 1. mothers selected for video-based anticipatory guidance that have a hearing/vision impairment. 2. mothers selected for handout-based anticipatory guidance who speak a language other than spanish or english. primary outcome measure: reduction in non-urgent ed visits in mothers who received the intervention (video-based and handout-based anticipatory guidance regarding non-urgent problems), compared to the control group (received cau anticipatory guidance) secondary outcome measure: improvement in parental knowledge, attitude and behaviors related to non-urgent problems as a result of receiving anticipatory guidance (video and handouts) regarding non-urgent problems;

Eligibility criteria:
inclusion criteria: * mother of a newborn in the wbn of bronx-lebanon hospital center during the 4-month recruitment period of the study exclusion criteria: * mothers selected for video-based anticipatory guidance that have a hearing/vision impairment. * mothers selected for handout-based anticipatory guidance who speak a language other than spanish or english.

Keywords: non-urgent ed visits neonates newborn care
monitoring lung recruitment maneuver in anesthetized morbidly obese

Conditions: Atelectasis

Summary: morbid obese patients present changes in respiratory physiology caused by weight overload. intraoperative atelectasis is a pulmonary complication that affects not only gas exchange but also respiratory mechanics. the present study was aimed to test the role of different parameters for monitoring the treatment of atelectasis by a lung recruitment maneuver.

this is a prospective study perform in 30 anesthetized morbidly obese undergoing bariatric surgery. lung mechanics and volumetric capnography will be non-invasively assessed during laparoscopy. esophageal pressure will be measured by an esophageal balloon to measure transpulmonary pressure. a lung recruitment maneuver will be done. the optimum level of positive end-expiratory pressure (peep) is defined as the peep level when transpulmonary pressure remains positive during the peep titration trial of the recruitment maneuver. lung collapse is detected when transpulmonary pressure becomes negative. the behavior of the studied volumetric capnography and lung mechanics parameters will be compared with the reference transpulmonary pressure signal.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) \> 40 kg/m2 * written inform consent * scheduled for bariatric surgery * american society of anesthesia physical status ii-iii exclusion criteria: * acute pulmonary disease * emergency surgery

Keywords: airways pressure mechanical ventilation atelectasis
tositumomab and iodine i 131-tositumomab in patients with relapsed indolent non-hodgkin's lymphoma

Conditions: Lymphoma, Non-Hodgkin

Summary: this study will further characterize the activity of tositumomab and iodine i 131-tositumomab in patients with relapsed indolent non-hodgkin's lymphoma who have progressed following treatment with rituximab.


Eligibility criteria:
inclusion criteria: * patients must have evidence of persistent or progressive follicular grade, 1, 2 or 3 or marginal zone b-cell non-hodgkin's lymphoma. * must have received at least two prior courses of systemic treatment including at least one treatment of rituximab (lymphoma must not have progressed during their most recent systemic chemotherapy treatment). * must have evidence that their lymphoma expresses cd20 antigen and have adequate renal and hepatic function. exclusion criteria: * received chemotherapy, radiation therapy, immunosuppressants or cytokine treatment within 4 weeks prior to study entry. * have active obstructive hydronephrosis. * had prior autologous hematopoietic stem cell transplant or any allogenic stem cell transplant. * have active infection requiring iv antibiotics. * have brain or leptomeningeal metastasis. * had previous allergic reaction to iodine, previously received radioimmunotherapy or are currently receiving approved or experimental anti-cancer drugs. * patients who are pregnant or breast feeding, have known hiv infection, or are human anti-murine antibody (hama) positive. * other criteria will be evaluated at the screening visit.

Keywords: bexxar non-hodgkin's lymphoma tositumomab i-131
study of high-dose influenza vaccine efficacy by repeated dosing in gammopathy patients

Conditions: Influenza; Multiple Myeloma; Waldenstrom's Macroglobulinemia; Plasma Cell Disorders; MGUS

Summary: the investigators' hypothesis is that the administration of fluzone® high-dose with booster to all patients with monoclonal gammopathies (irrespective of age) will lead to seroconversion rates exceeding 50% and more importantly, will reduce influenza-related morbidity, reduce interruptions in cancer therapy and may reduce disease progression at the end of the flu season

influenza is a major cause of morbidity in the us. patients with monoclonal gammopathies are known to have increased risk of developing influenza. furthermore, several of the medications (such as proteasome inhibitors), commonly used to treat these tumors, are known to further increase the risk of these tumors. seasonal influenza vaccination has been shown to reduce influenza related morbidity and is approved for routine prophylaxis in us. in 2009, fluzone® high- dose vaccine was fda approved in 2009 for adults aged 65 and older based on the data regarding higher rates of seroprotection (defined as hemagglutination antibody inhibition (hai) titer of 40 or higher). in this study, the investigators will administer fluzone® high-dose vaccine with a planned booster to patients with monoclonal gammopathies irrespective of age versus a standard of care control group. primary endpoint is composite of documented influenza infection rate and disease progression (as defined by international myeloma working group criteria) at the end of the flu season. based on the background data, the investigators expect a higher rate of success in the experimental arm. as such, the investigators power for success rates of 90% and 70% in the experimental and control arms, respectively. the investigators will also analyze several secondary endpoints including rates of influenza related morbidity, the analysis of humoral and cellular immune response to these vaccines and the rate of disease control (defined as lack of disease progression by standard international myeloma working group criteria).

Eligibility criteria:
inclusion criteria: * understand and voluntarily sign an informed consent form. * age ≥18 years at the time of signing the informed consent form. * diagnosis of any monoclonal gammopathy: monoclonal gammopathy of undetermined significance (mgus), asymptomatic / active multiple myeloma, asymptomatic / active waldenstrӧm macroglobulinemia (wm). exclusion criteria: * any serious egg allergy or prior serious adverse reaction to an influenza vaccine. * use of any other influenza vaccine for the 2015 to 2016 flu season. * women who are pregnant or plan to become pregnant in the study period.

Keywords: influenza multiple myeloma waldenstrom's macroglobulinemia
mild carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome (cts) is the most common peripheral nerve entrapment. diagnosis is based on symptoms, clinical findings and electrophysiological examination. several conservative and surgical treatment options have been described. studies of surgical versus conservative treatment in mild carpal tunnel syndrome have not been done and it is still unclear whether or not surgical treatment is better than conservative treatment. the aim of this study is to research has surgery better outcome in mild cts than conservative treatment. patient satisfactory, clinical and electrophysiologic outcomes, direct and indirect costs will be evaluated.


Eligibility criteria:
inclusion criteria: * electrophysiologically proven minimal or mild cts lasting more than six months will be included in this study exclusion criteria: * rheumatoid arthritis * diabetes mellitus * hypothyreosis * pregnancy * wrist trauma or previous surgery * splinting or corticosteroid injection on the affected side

Keywords: carpal tunnel syndrome cts medianus impingement