Kornimate/medical-research-clean huggingface dataset:
non opioid treatment for experimental dyspnea

Conditions: Dyspnea; Pain

Summary: the purpose of this protocol is to test the effects of the non opioid nefopam on experimental dyspnea and on the counterirritation (ie inhibition of one pain by another pain) induced by dyspnea in healthy subjects.

dyspnea and pain share many features. one of them is the counterirritation phenomenon: defined in pain research as the attenuation of one pain by another pain. dyspnea induced with inspiratory threshold loading (increased sense of work/effort ) has been shown to attenuate electrical pain as shown through nociceptive flexion reflex inhibition, or thermal pain, as measured with cortical evoked responses (laser evoked potentials-lep). the investigators will study whether nefopam modulates the counterirritation of laboratory induced dyspnea in healthy subjects. the effect of nefopam on experimental dyspnea will be measured with a visual analog scale (vas) and a validated multidimensional dyspnea profile (mdp). the effect of treatment on counterirritation will be measured by recording lep obtained using a co2 laser system. the amplitude of the n2-p2 component of the lep is the main study outcome.

Eligibility criteria:
inclusion criteria: * healthy * non-smoking exclusion criteria: * acute or chronic pain * antalgic or psychoactive drugs use * nefopam hypersensibility * severe allergy * diabetes * glaucoma * prostate adenoma * seizure disorder or convulsion history * heart or circulation disease * pulmonary disease or asthma * kidney or liver disease * brain or nerve disease * lack of adhesion to no antalgic drug, alcohol, coffee and cola within previous experiment day consumption

Keywords: dyspnea pain
effects of clinical pilates and yoga training in lymphedema

Conditions: Lymphedema; Exercise

Summary: the aim of our study is to compare the effects of clinical pilates and yoga training on lymphedema, upper limb muscle strength, proprioception, functions and quality of life in women with lymphedema after breast cancer.

a total of 60 post breast cancer lymphedema individuals will be included in our study. the study will be performed in individuals who live in t.r.n.c and who develop mild, moderate or severe lymphedema after breast cancer in the 35-70 age range. a randomized controlled trial design with three groups were used; 1) a hatha yoga intervention group, 2) clinical pilates intervention group, 3) control group. individuals in the intervention groups will be given 24 sessions of yoga or clinical pilates training 3 times a week for 8 weeks. control group will not receive any treatment. during the training, and control group individuals will be asked to wear compression stockings during the 8 weeks and an educational booklet will be given to the each group. the yoga classes included a progression of low-impact, modified poses, stretching and isometric exercises focused on the shoulders, arms, and chest, and meditation. breathing and poses to drain the lymphatic system were incorporated throughout the yoga practice to assist with lymphatic flow. before starting the clinical pilates exercise program, the patients will be trained on pilates exercises and postures. during training, the patients will be taught how to create lumbopelvic stability (core stabilization), which is the basis for pilates exercises, and spinal stabilization and appropriate posture techniques. as a result of the research, the data will be analyzed to determine which treatment method is more effective in lymphedematous individuals.

Eligibility criteria:
inclusion criteria: * breast cancer survivors, * who are between the ages of 35-70, * who have unilateral mild, moderate or severe * lymphedema in the upper extremities after breast cancer treatment, * who have taken any of the lymphedema treatment methods at least 6 months ago will be included. exclusion criteria: * presence of metastatic breast cancer, * currently receiving adjuvant therapy (chemotherapy, radiotherapy, hormone therapy), * severe heart failure (class iii), * infections in extremities (fungal, redness, temperature increase), * severe pain in the axillary region (eg: axillary web syndrome, * reflex sympathetic dystrophy, neuropathy), * persons participating in a regular exercise program in the last 6 months will be excluded from the study.

Keywords: pilates yoga volumetric measurement muscle strength dynamometer respiratory function tests
peripheral blood dna methylation markers for the early detection of colorectal carcinoma in the egyptian population

Conditions: Colorectal Neoplasms; Adenoma; Colorectal Tumors

Summary: the incidence of colorectal cancer (crc) is on the rise on a global scale. the number of cancer-related deaths related to crc is also rising to an alarming level. this picture is similarly seen in egypt where the incidence of colorectal carcinoma is increasing annually, moreover, crc in egypt exhibits an alarming characteristic which is the affection of much younger patients than their counterparts worldwide. fortunately, the early detection of crc and its precursor (adenoma) has been shown to markedly decrease morbidity and mortality related to this tumor, this has prompted the development of robust screening programs for crc in several western countries. the implementation of a crc screening program in egypt has been hampered by the low compliance of the patients and the relatively high cost of colonoscopy. there is a need for an affordable, non-invasive, simple, accurate and socially accepted screening test to allow such a program to succeed in egypt. recent studies have shown that dna is the future target of screening tests for several malignancies. particularly for crc a few preliminary studies have shown encouraging results with separate dna methylation markers both in blood and stool. in our efforts to develop a screening test with the criteria stated above, the investigators have decided to join the forces of 2 of the largest medical centers in egypt and the middle-east: kasr-alaini hospital and the national cancer institute (nci). the investigators plan to test a panel of 7 dna methylation markers in peripheral blood for their performance as an early marker for crc and colorectal adenomas. data from this study will pave the way for the development of a screening test for crc "tailored" to the egyptian population, moreover, it will supply essential data about the genetic alterations occurring in crc in egyptian patients.


Eligibility criteria:
inclusion criteria: * patients undergoing colonoscopy as part of their clinical care or part of screening program. * complete endoscopic examination (up to the caecum) * adequate colonic preparation exclusion criteria: * - incomplete colonoscopic examination due to technical causes e.g. difficult colonoscopy, patient intolerance (n.b. a neoplastic mass causing lumen stenosis will not be excluded.) * poor colonic preparation obscuring adequate mucosal examination. * patients who have received any treatment for crc and/or adenomas. * patients with known malignancy elsewhere (i.e. non-colorectal malignancy)
clinical and dynamic floor mri evaluation before and after prolapse surgery

Conditions: Prolapse

Summary: pelvic organ prolapsed, associated with defecation disorders and urinary tracts symptoms are common and affect up to 25% of the population, mostly parous women. the pelvic floor must be seen as one entity, with multiple anatomical and physiological interactions between the various compartments (rectum, vagina, uterus and bladder) which are embedded in the same anatomical region. the often complex pathologies of this region should therefore be treated in a multidisciplinary setting. besides clinical evaluation, functional dynamic imaging of anorectal and pelvic floor disfunctions has an important role in the diagnosis and management of these disorders. although the colpocystodefecography is still considered to be the golden standard in imaging this complex anatomical region, there is clearly a need for more precise imaging of the structural details, preferentially without any irradiation. transperineal ultrasound is an option but the investigators have chosen to evaluate the use of dynamic magnetic resonance imaging. in contrast to colpocystodefecography, dynamic pelvic floor magnetic resonance imaging is an evolving technology and its precise role in functional imaging of the pelvic floor still remains to be determined. prolapse surgery is commonly performed and therefore it is important to assess the efficacy of the operations in correcting the anatomical defects and the symptoms associated without creating new, pelvic floor related symptoms. few studies exist today allowing the assessment of the anatomical changes and symptoms after surgery, through abdominal or perineal approach. this study will evaluate the reliability of the dynamic pelvic floor imaging, done in a sitting position, compared to colpocystodefecography, done in a sitting position. it will also compare clinical objective and subjective results related to pelvic floor abnormalities with imaging. finally, it will evaluate the anatomical changes in correlation with the clinical results, organ position and inter-compartments relationships after surgery. this study will allow to understand and explain some relapses and failures and could lead to an improvement of the indications for surgery and surgical techniques used.


Eligibility criteria:
inclusion criteria: all patients who will undergo internal or external rectal prolapse, enterocele or urogenital prolapse surgery in chu brugmann and chu st pierre. exclusion criteria: * mri contra-indications * patients with prior pelvic floor surgery

Keywords: dynamic floor magnetic resonance imaging colpocystodefecagraphy prolapse surgery
preoperative warm-up in gynecologic surgery

Conditions: Gynecologic Disorders

Summary: background and objectives: all modern surgical procedures require a high level of cognitive and psychomotor skills achieved using different training methods, but could be influenced by fatigue and other psychological factors. we evaluate the effect of warm-up exercises on operative laparoscopic performances in gynecologic laparoscopic procedures. methods: the surgical team operates on a consecutive series of 20 patients and perform laparoscopic salpingo-oophorectomy. patients are randomly allocated in 2 groups: group a to be operated on without warm-up exercises and group b to be operated on after a short-term warm-up. all patients are operated on by the same surgical team. the full-time records of the operation were analyzed by 2 independent reviewers. laparoscopic procedures are recorded and assessed by 2 independent observers using the generic osats rating scale. a training module using the lap sim simulator was designed for the warm-up.


Eligibility criteria:
inclusion criteria: * residents or faculty at the dept. of gynecology and obstetrics * completed skills training exclusion criteria: * none

Keywords: laparoscopy surgery warm-up preoperative surgical skills
comparison of nn5401 versus insulin glargine, both combined with metformin treatment, in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia, europe and the united states of america (usa). the aim of this trial is to compare the efficacy and safety of nn5401 (insulin degludec/insulin aspart (idegasp)) with insulin glargine (iglar), both as add-on to subject's ongoing treatment with metformin + at least one oad (oral anti-diabetic drug). the main period is registered internally at novo nordisk as nn5401-3590 while the extension period is registered as nn5401-3726.


Eligibility criteria:
inclusion criteria: * for main period (nn5401-3590): * diagnosis of type 2 diabetes mellitus for at least 6 months * insulin naïve subjects * treatment with metformin and at least one other oral antidiabetic drug for at least 3 months before trial start * glycosylated haemoglobin (hba1c) between 7.5 - 11.0% (both inclusive) * body mass index (bmi) no higher than 40.0 kg/m\^2 * for extension period (nn5401-3726): * informed consent obtained before any trial-related activities * must have completed the 26-week treatment period (visit 28) in trial nn5401-3590 exclusion criteria: * for main period (nn5401-3590): * treatment with glucagon like peptide-1 (glp-1) receptor agonists and/or thiazolidinedione(s) within the last 3 months prior to trial start * cardiovascular disease diagnosed within 6 months before trial start * for extension period (nn5401-3726): * anticipated change in concomitant medication known to interfere significantly with glucose metabolism, such as systemic corticosteroids, beta-blockers, monoamine oxidase (mao) inhibitors * anticipated significant lifestyle changes during the trial, e.g. shift work (including permanent night/evening shift workers), as well as highly variable eating habits as judged by the physician) * pregnancy, breast-feeding, the intention of becoming pregnant or not using adequate contraceptive measures according to local requirements
open-label extension trial of pde4 inhibition with roflumilast for the management of plaque psoriasis

Conditions: Chronic Plaque Psoriasis

Summary: this study will assess the safety and efficacy of arq-151 cream applied once a day for 24 weeks by subjects with chronic plaque psoriasis

this is an open-label study in which arq-151 cream is applied once daily x 24 weeks to subjects with psoriasis

Eligibility criteria:
inclusion criteria: * participants legally competent to sign and give informed consent or informed consent of legal guardian, and, if age appropriate, assent by the subject, as required by local laws * males and females ages 2 years and older (inclusive) * subjects with chronic plaque psoriasis who meet eligibility criteria and: 1. successfully completed a prior arq-151 cream study in psoriasis (cohort 1) or 2. are naïve to treatment with arq-151 cream (cohort 2) * females of childbearing potential (focbp) must have a negative pregnancy test at all study visits. in addition, sexually active focbp must agree to use at least one form of highly effective contraception throughout the trial. exclusion criteria: * subjects who experienced an arq-151 treatment-related ae or a serious ae (sae) that precluded further treatment with arq-151 cream in a prior arq-151 cream study. * planned excessive exposure of treated area(s) to either natural or artificial sunlight, tanning bed or other led. * females who are pregnant, wishing to become pregnant during the study, or are breast-feeding. * subjects with any serious medical condition or laboratory abnormality that would prevent study participation or place the subject at significant risk, as determined by the investigator. * subjects with a history of chronic alcohol or drug abuse within 6 months of initiation of investigational product. * subjects who are unable to communicate, read or understand the local language, or who display another condition, which in the investigator's opinion, makes them unsuitable for clinical study participation.
mechanisms of change, motivation, and treatment outcome in alcohol dependence - posttraumatic stress disorder

Conditions: Alcohol Dependence; Posttraumatic Stress Disorder

Summary: the purpose of this study is to test if provision of an effective psychotherapy for post-traumatic stress disorder (ptsd), prolonged exposure, can be tolerated in alcohol dependent patients with ptsd and if it is associated with better treatment outcomes compared to an active control condition.


Eligibility criteria:
inclusion criteria: * current ptsd * current alcohol dependence * at least one heavy drinking day in the past 60 days exclusion criteria: * psychotic disorder * untreated bi-polar disorder * benzodiazepine use
effectiveness of specific strength training combined with static stretching of the posterior neck in office workers with chronic neck pain: a clinical trial

Conditions: Neck Pain; Work Injury

Summary: objective: to determine the effectiveness of strength training combined with stretching compared to specific strength training in office workers with chronic neck pain. methods: a single blind randomized clinical trial will be conducted. participants will be adult of both sexes with sedentary office work and chronic neck pain. the intervention will consist of a strength training program for the neck and shoulder muscles combined with static stretching of the neck, while the comparison group will only perform strength training. in addition, both groups will receive ergonomics guidelines. short-term, medium-term, and long-term evaluations will be performed using the northwick park neck pain questionnaire (npq), neck disability index (ndi), and tampa scale of kinesiophobia (tsk).


Eligibility criteria:
inclusion criteria: * adults aged between 18 and 70 years. * workers from companies in the community of madrid. * sedentary employees who work at least 20 hours in the office. * subjects with nonspecific chronic neck pain. * all individuals who have decided to participate voluntarily after having read and signed the patient information sheet and the informed consent form. exclusion criteria: * arterial hypertension (systolic bp \>160, diastolic bp \>100) or cardiovascular diseases. * diagnosed metabolic disorders. * symptomatic disc herniation or severe cervical spine disorders. * postoperative conditions. * history of severe trauma to the neck and shoulder region. * pregnancy. * subjects with a body mass index (bmi) greater than 29.9 kilograms per square meter (kg/m2). * presence of physical or mental impairments that prevent the correct execution of the interventions and/or their corresponding evaluation. * having undergone surgery in the previous six months. * participating in parallel research studies. * not having a permanent job position. * using two monitors. * using a laptop.

Keywords: randomized controlled trial neck pain exercise occupational health
cardiac imaging in sars-cov-2 (covid-19)

Conditions: COVID

Summary: one-in-four patients with covid-19 pneumonia develop life-threatening heart problems. through cardiovascular imaging and biomarkers analyses this study aims to evaluate whether covid-19 infection results in heart injury. the investigators will also investigate which patients are at risk of heart injury as a result of covid-19 and why only some patients suffer heart problems as a consequence of the infection. the study will also assess multisystem involvement including the lungs and kidneys.

our study is supported through the chief scientist office rapid research in covid-19 (rarc-19) programme. our study will clarify the pathogenesis of cardiopulmonary injury, notably endotypes of myocardial injury including myocarditis, in patients with covid-19. the study involves a prospective, observational, multicentre, longitudinal cohort design.the investigators aim to minimise selection bias by adopting consecutive screening of all-comers hospitalised with covid-19 and the eligibility criteria are broad. for example, severe renal dysfunction is not an exclusion criterion. the sample size is 180 patients enrolled at baseline with 160 attending for the primary outcome evaluation (cardiac imaging) at 28 days post-discharge. the investigators will use advanced cardiovascular imaging to identify the number (proportion) of patients with myocardial inflammation (myocarditis) that is sub-clinical (i.e. not diagnosed) or clinically overt. cardiovascular mri and ct coronary angiography will provide a comprehensive examination one month after discharge is intended to detect persisting cardiovascular complications and diagnose clinical endotypes. the investigators aim to clarify the pathological significance of serial changes in circulating troponin, ntprobnp and renal function. by correlating the mri findings with troponin i and other measures of cardiovascular injury, such as ntprobnp, our results will inform care pathways that use these blood tests to guide the management of patients with covid-19. correlation of imaging findings with baseline clinical information, biomarkers, patient reported outcome measures and well-being in the longer term will help to clarify the clinical significance of cardiovascular complications in covid-19. since the design is observational, an interim analysis may be undertaken with the timing informed by the enrolment rate. longer term follow-up will include a 5-year visit, contingent on funding and ethics approval, and electronic health record linkage of vital status and episodes of nhs care.

Eligibility criteria:
inclusion criteria: * history of hospital attendance or hospitalisation for covid-19, confirmed by a clinical diagnosis, laboratory test e.g. pcr and/or a radiological test e.g. ct chest or chest x-ray * age 18 years or more * capacity to provide written informed consent * able to comply with study procedures exclusion criteria: * contra-indication to cmr e.g. severe claustrophobia, metallic foreign body * lack of informed consent * women who are pregnant, breast-feeding or of child-bearing potential without a negative pregnancy test
empowerment training on type 2 diabetes patients on empowerment levels and clinical findings

Conditions: Diabetes Mellitus, Type 2; Empowerment; Patient Empowerment

Summary: in this study, the effect of nurse-led empowerment training given to patients with type 2 diabetes on clinical findings and empowerment behaviors will be investigated.

the research is a randomized controlled design research that includes a pre-test/post-test design. the primary outcome expected in the research; change in empowerment behaviors as a result of the training given; secondary outcomes are changes in clinical findings. the research universe; all type 2 diabetes patients who applied to the endocrinology polyclinic of a private hospital in eskisehir city center between march-july 2019 consisted of. in the study, the sample was randomly selected, and it was aimed to reach all patients with type 2 diabetes who were 18 years of age and older, with a diagnosis period of one year or more. in the study, patients were randomly assigned to the intervention group, which included 6 weeks of training, or to the control group, which was on a 6-week waiting list. it used a question-based format to address the educational, behavioral, and psychosocial needs of patients within the scope of a 12-hour empowerment program that lasted for 6 weeks, 2 hours a week. education (dsms (developing empowerment-based diabetes self-management support)) is planned as stated literature. purpose of education: empowerment as a philosophy of care emphasizes a collaborative approach to facilitating behavior change for patients themselves. empowerment approach; goal setting is a five-step process that provides patients with the knowledge and clarity they need to develop and achieve their diabetes and lifestyle goals. the first two steps are to identify the problem and identify patients' beliefs, thoughts, and feelings that may support or hinder their efforts. the third step is to determine the long-term goals expected from patients. in this step, patients are then expected to make a behavioral change that will help them achieve their long-term goals. the last step is for patients to evaluate their efforts and determine what they have learned in the process. empowerment training was determined within the framework of this process.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus diagnosed more than 1 year ago exclusion criteria: * mental retardation * dementia * deafness * blindness * psychiatric illness * steroid use