Kornimate/medical-research-clean huggingface dataset:
therapeutic effects of neurofeedback in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: the purpose of this study is to determine whether neurofeedback training can significantly reduce the symptoms of anorexia nervosa (an) with focus on changes in personality and psychological well-being. the primary aims of this study include: 1. to examine whether an patients are able to control their alpha-activity through neurofeedback. 2. to examine the effects of neurofeedback on symptomatology and personality variables in an patients. 3. to examine the long-term effects of neurofeedback in the treatment of an.

the aim of the present study is to investigate the impact of eeg frequency band biofeedback (neurofeedback) training on eeg topography and symptomatology of patients suffering from anorexia nervosa (an). there is evidence that alpha-neurofeedback leads to an increase in positive therapy outcome in clinical populations by changing long-lasting eeg frequency patterns. the use of an eeg-guided relaxation paradigm has been shown to be associated with well-being and improvements in pathology of psychiatric patients. in the present study the effects of alpha-training on eeg activity, mood, personality, well-being, blood parameters, and heart frequency will be evaluated in a sample of anorectic girls (12-18 years). the subjects are trained with at least 10 sessions alpha-neurofeedback, in order to enhance individual alpha frequency, with spectral resting eeg, ekg, blood samples, erp-measures and psychometric measures assessed before and after training. neurofeedback is conducted over a period of five weeks, with each participant receiving two training sessions per-week. neurofeedback is administered using usbamp-eeg system. for better surveillance of training effects there are two non-treatment control groups. a patient group receiving conventional therapy programme of the psychosomatic division of the pediatric department at the university hospital graz and a healthy control group. a twelve-week follow-up study is carried out in order to document long-term effects of alpha-neurofeedback training in an patients.

Eligibility criteria:
inclusion criteria: * anorexia nervosa diagnosed by icd-10 exclusion criteria: * epilepsy or other brain organic diseases

Keywords: neurofeedback, alpha, anorexia nervosa
incas - integrated care of asthma in switzerland

Conditions: Asthma

Summary: the aim of this study was to investigate the effect of standardized patient education on asthma control. in collaboration with two health insurance companies, pharmacists and pneumologists, patients with asthma were recruited. they completed the "asthma control test (act)" and the "patient assessment of chronic illness care (pacic 5a)" questionnaire to assess asthma control and patients' satisfaction with the health care service they received. additionally, patients were offered the possibility to participate in a patient education seminar run by the swiss lung leagues or the swiss allergy centre (aha!). after one year, patients were asked to complete the questionnaires again. comparisons of intraindividual changes and differences regarding act and pacic 5a between patients with and without patient education were made.


Eligibility criteria:
inclusion criteria: * patients with clinical asthma diagnosis * written informed consent exclusion criteria: * inadequate knowledge of the german language * subjects with severe diseases with life expectancy under one year * subjects with known chronic obstructive pulmonary disease (copd)
electroencephalography in patients resuscitated from cardiac arrest

Conditions: Cardiac Arrest; Heart Arrest

Summary: sudden cardiac death can occur due to a multitude of causes. the underlying case can affect the overall prognosis. a return of spontaneous circulation not exceeding 30 minutes following a successful cardiopulmonary resuscitation is usually deemed imperative, if the patient is to survive. monitors for evaluating the cardiac function during and after resuscitation are implemented on a daily basis (ekg, pulseoxymetry, blood pressure monitoring, cardiac sonography), but no devices for registration of the cortical brain activity exist. the aim of this study is to provide a 3-channel electroencephalogram using a prototype eeg/ekg adapter, connected to a physio-control lifepak 15 monitor/defibrillator, in patients who regain spontaneous circulation following non-traumatic cardiac arrest.


Eligibility criteria:
inclusion criteria: * witnessed cardiac arrest * return of spontaneous circulation following cardiac arrest 10-40 min exclusion criteria: * traumatic cardiac arrest * no consent from next-of-kin

Keywords: electroencephalography
management of post-circumcision ischemia using hyperbaric oxygen therapy

Conditions: Post-circumsion Complications

Summary: background: post-circumcision penile ischaemia is a rare but destructive complication. our goal is to present our experience in the management of children, who had different forms of penile ischaemia, complicating the routine ritual male circumcision. material and methods: all male children who had post-circumcision penile ischaemia between april 2017 and october 2020 were included in the study. a special designed protocol for management of all cases includes a combination of early pentoxifylline intervenes infusion with hyperbaric oxygen inhalation, early catheterization, and appropriate surgical debridement. data were analyzed inclusively to patient age, the anesthesia method used, monopolar diathermy usage, early presentation, method of circumcision and positive wound culture.

it is a cohort prospective study. all male children who had penile ischaemia after circumcision were included in the study between april 2017 and october 2020. a special designed protocol includes early admission of a child in paediatric intensive care unit (picu). catheterization by suitable size silicon foley's catheter appropriate for the age. iv pentoxifylline in a dose of 10 mg/kg/day divided into 3 equal doses with good monitoring of its side effects mainly tachycardia and convulsions. iv 3rd generation cephalosporin with suitable doses according to the age and body weight. hyperbaric oxygen therapy is a specially designed cabinet for infants and neonates with a barometric pressure equal to 760 mmhg for 20 minutes daily, then gradually increase up to one hour daily for 5 days per week (fig. 1). the chamber was kept warm. the babies were fed before entering the chamber and if signs of hunger appear during therapy. the baby was continuously monitored with pulse oximeter. older children are managed in the conventional hyperbaric oxygen chamber with the same regimen. proper surgical debridement together with daily topic dressing with nitroglycerin ointment (2%). the treatment continued through the admission period. follow up period range from 6 months up to 3 years. data were analyzed inclusively to patient age, the type of medical provider who performed the circumcision, the technique of male circumcision, the anesthesia method used, if any monopolar diathermy usage, wound suturing after mc, the duration of between male circumcision and presentation to our protocol, and the final condition of the patient at discharge and after 6 months.

Eligibility criteria:
inclusion criteria: - male children complained of penile ischaemia after circumcision. exclusion criteria: * other post-circumcision complication not include penile ischaemia * patients with chronic diseases.

Keywords: glans necrosis, hyperbaric oxygen, male circumcision, pentoxifylline, monopolar cautery.
inelastic compression in edema after revascularization

Conditions: Lymphedema

Summary: the appearance of revascularization edema of the lower limb is a frequent complication in peripheral vascular surgery. it can lead to a delay in healing and even to trophic disorders. the prevention and treatment of this complication have so far been limited to postural measures (elevation of the limbs), in the absence of other recommendations and given the contraindication of elastic compression. inelastic compression is another mode of compression sometimes used in the treatment of lymphedema. it exerts a stable continuous pressure regardless of the patient's position. the investigator's aim is to demonstrate that compression with inelastic bands, applied under good conditions, does not have a major effect on distal arterial vascularization in arterial patients who have undergone revascularization by supra-articular bypass or endovascular treatment of the lower limb.


Eligibility criteria:
inclusion criteria: 1. patients over 18 years of age 2. arteriopathic patients requiring femoropopliteal revascularization by bypass surgery who have been revascularized 3. signature of an informed consent 4. person affiliated or beneficiary of a social security plan exclusion criteria: 1. arterial bypasses under the leg or distal joints 2. critical ischemia 3. patients operated on for acute ischemia 4. pregnant or breast-feeding women 5. severe cardiac insufficiency 5) severe peripheral neuropathy 6) allergies to the components of the tapes 7) persons deprived of liberty by judicial or administrative decision 8) persons under legal protection
lobectomy and mediastinal radiochemotherapy in unresectable stage iii non-small cell lung cancer responding to induction chemotherapy

Conditions: Non Small Cell Lung Carcinoma

Summary: the purpose of this study is to determine if radical radiochemotherapy on the mediastinum after lobectomy can be associated with significant long term survival in patients with initially unresectable stage iii nsclc responding to induction chemotherapy but in which the residual disease is too large to be treated by radiotherapy.


Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of non-small cell carcinoma of the lung * initially stage iii nsclc * pathologically proven n2 or n3 disease * any response to induction chemotherapy (whatever the regimen administered) * disease still not fully resectable (because of extensive mediastinal n disease) and not suitable for radical radiotherapy (single field) after induction chemotherapy * lobectomy possible for the treatment of t disease * availability for participating in the detailed follow-up of the protocol * informed consent exclusion criteria: * prior treatment with radiotherapy or surgery * karnofsky ps \< 60 * functional or anatomical contra-indication to mediastinal radiotherapy * functional or anatomical contra-indication to surgical lobectomy * a history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or cured malignant tumour (more than 5 year disease-free interval) * malignant pleural or pericardial effusion * neutrophils \< 2,000/mm³ * platelet cells \< 100,000/mm3 * serum bilirubin \> 1.5 mg/100 ml * serum creatinine \> 1.5 mg/100 ml and/or creatinine clearance \< 60 ml/min * recent myocardial infarction (less than 3 months prior to date of diagnosis) * congestive cardiac failure or cardiac arrhythmia requiring medical treatment * uncontrolled infectious disease * hearing loss * symptomatic polyneuropathy * serious medical or psychological factors which may prevent adherence to the treatment schedule

Keywords: non-small cell lung carcinoma concomitant radiochemotherapy cisplatin vinorelbine radiotherapy chemotherapy unresectable stage iii non-small cell lung carcinoma surgery unresectable stage iii non-small cell lung carcinoma not suitable for radical radiotherapy after objective response to induction chemotherapy
evaluation of the effect of narrowband uvb versus methotrexate on serum tweak level in psoriasis

Conditions: Psoriasis

Summary: the aim of the study is to evaluate the effect of nb-uvb versus mtx on serum tweak level in psoriatic patients.


Eligibility criteria:
inclusion criteria: * patients with moderate to severe plaque psoriasis of any age and gender. exclusion criteria: * history of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months. * pregnancy and lactation. * infections * patients with chronic diseases: hepatic disorders, hematologic disease, chronic renal failure or cancer
total knee arthroplasty and clinical findings

Conditions: Orthopedic Disorder; Arthropathy of Knee; Pain, Joint; Proprioception; Radiography

Summary: knee osteoarthritis is a common disease that causes pain and loss of function. total knee arthroplasty (tka) is a frequently used surgical method in the treatment of severe knee osteoarthritis. the aim of this study was to investigate the effect of tka on il-6, tnf-α and il-1β cytokine levels, pain intensity at rest and walking, knee joint valgity angle,malaligment, functional status and knee joint position sense.

twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the tka group (study group) and 22 patients (female/male:13/9) with \<grade 4 osteoarthritis were included in the control group. systemic venous blood samples of the patients were taken to evaluate the cytokine level (il-6, tnf-α, il-1). the visual analogue scale was used to assess pain intensity, and the womac (western ontario and mcmaster universities osteoarthritis index) score was used to evaluate the functional status. valgity and malaligment measurements were calculated using antero-posterior x ray digital goniometer was used to evaluate the knee joint position sense (at 35, 55 and 70 degrees knee flexion angles). measurements were taken once from patients in the control group, and twice in pre-op and post-op sixth weeks from study group.

Eligibility criteria:
inclusion criteria: * patients with grade 4 degeneration levels who had surgical indications between the ages of 45-75 were placed in the study group. * patients without surgical indication, lower than 4 oa severity included in the control group exclusion criteria: * patients with surgical history of the ipsilateral side, neuropathic pain, loss of sensation, systemic, chronic and infectious disease were excluded from the study
evaluation of knowledge among adolescents with sickle cell disease.

Conditions: Sickle Cell Disease

Summary: evaluation of knowledge about contraception in sickle cell adolescents.

sickle cell teenagers receive regular hospital medical care. adolescence is the time when the pathophysiology of the disease is re-explained and when questions around puberty (possibly delayed), sexuality and contraception are discussed. sickle cell disease, like any chronic disease, can have repercussion on the development and behavior of young patients. knowledge and understanding of young patients with sickle cell disease around these issues may be insufficient.

Eligibility criteria:
inclusion criteria: * patients with sickle cell disease followed at the chic * aged 14 to 19 * both sexes exclusion criteria: * neurological disorders that can impede understanding of the questionnaire. * refusal to participate. * not affiliated to social security.
eradication rate between 1- and 2-week helicobacter pylori eradication therapy

Conditions: H.Pylori Gastrointestinal Disease

Summary: it is recommended as the first line treatment regimen to eradicate helicobacter pylori (hp), 7 or 14 days treatment of proton pump inhibitor (ppi) based triple therapy consisting of one ppi and two antibiotics, clarithromycin and amoxicillin. in the case of treatment failure, 7 or 14 days of quadruple therapy (ppi＋metronidazole＋tetracycline＋bismuth) is recommended. this study aims to investigate which duration would be better for eradication of hp. the study design is a randomized controlled trial. the patients were randomly assigned to 7 days or 14 days treatment groups. primary endpoint was the eradication rate of ppi based triple therapy. secondary endpoints were to compare the rate of drug compliance and side effects in both groups.

the recommended duration of triple therapy is typically 10 to 14 days in the united states and 7 days in europe. in korea, it is recommended as the first line treatment regimen, 7 or 14 days treatment of proton pump inhibitor (ppi) based triple therapy consisting of one ppi and two antibiotics, clarithromycin and amoxicillin. in case for treatment failure which is often related to helicobacter pylori (hp) resistance to clarithromycin or metronidazole, bismuth-based quadruple therapy is commonly used as second-line therapy, however, the eradication rates was widely ranged according to the treatment duration. the objective of the study is to investigate whether treatment duration would affect the eradication rate of hp as a ppi based triple therapy (1st line therapy) and a bismuth-based quadruple therapy (2nd line therapy).

Eligibility criteria:
inclusion criteria: * peptic ulcer including ulcer scar * early gastric cancer * gastric mucosa-associated lymphoid tissue lymphoma exclusion criteria: * operation history * liver cirrhosis * chronic kidney disease * pregnancy
evaluation of visual functions after pars plana vitrectomy with and without internal limiting membrane peeling in rrd

Conditions: Retinal Detachment

Summary: internal limiting membrane peeling is performed during vitrectomy for macular diseases such as macular holes, macular edema due to diabetic retinopathy and retinal vein occlusion. the incidence of epiretinal membrane formation after vitrectomy for rhegmatogenous detachment has been reported to range from 4.4% to 12.8%. in this study, the efficacy and safety of internal limiting membrane peeling will be studied in vitrectomy for rhegmatogenous retinal detachment and if it is essential to peel it in those cases or not.

interventional observational study comparing vitrectomy with versus without internal limiting membrane peeling in cases of rhegmatogenous retinal detachment.

Eligibility criteria:
inclusion criteria: * all eyes with recent macula-off rhegmatogenous retinal detachment (rrd). exclusion criteria: * complicated cases with advanced proliferative vitreoretinopathy (pvr). * patients with retinal vascular disorders and other macular disorders. * combined tractional and rhegmatogenous detachment. * previous retinal reattachment surgery or intravitreal injections. * glaucomatous patients. * patients with corneal opacity which impairs good visualization.

Keywords: internal limiting membrane multifocal electoretinogram (erg) oct-angiography
fundus image-guided focal electroretinography, usability study

Conditions: Healthy; Macular Edema; Macular Degeneration

Summary: the purpose of this study is to investigate the usability of fundus image-guided focal electroretinography device with healthy subjects and with macular edema and macular degeneration patients.

in this study, we will study the usability of focal electroretinography device combined with slit lamp biomicroscope. the device allows simultaneous fundus imaging and focal erg recording from the desired retinal area. in phase i, the usability of the investigational device is tested with 10 healthy volunteers. the examinations include focal erg and noise tests with commercial erg electrodes. the stimulus lights are guided to the fundus using either non-contact of contact fundus lens. one electrode is selected for phase ii based on signal-to-noise ration, usability, and comfort. in phase ii, fundus image-guided focal erg recordings are conducted with total of 10 patients having either macular edema or macular degeneration. the aim of the phase ii is to test whether the investigational device can be used to record focal erg signal from the desired symptomatic retinal area.

Eligibility criteria:
inclusion criteria: * healthy volunteers with no signs of macular edema or macular degeneration (phase i) * patients with either macular edema or macular degeneration (phase ii) * able to give informed consent exclusion criteria: * epileptic patients * vulnerable population: pregnant and breastfeeding women, underage, prisoners, persons with physical handicaps or mental disabilities, and disadvantaged persons.

Keywords: electroretinography erg
disseminating nih evidence based sickle cell recommendations in north carolina

Conditions: Sickle Cell Disease

Summary: this project will improve the efficiency and quality of healthcare for persons with sickle cell disease, an under-served and at risk population by implementing a co-management model of care. many patients with sickle cell disease (scd) receive care primarily from specialty physicians and emergency departments (ed), thus resulting in a lack of primary care and a high number of ed visits and hospitalizations. the goal is to improve pcp and scd specialist co-management. the overall purpose of this dissemination project is to evaluate utilization data, as well as patient and provider reported outcomes associated with the dissemination of a toolbox of decision support tools to pcp's and ed providers across nc and sc.

the investigators will achieve the goals stated above through three aims. 1. examine the effects of decision support tools on study outcomes during the 12 months prior to project start and across the 3.5 years of the project in nc and sc. the investigators will also determine which patient and practice level characteristics predict study outcomes. 2. evaluate individual provider-reported awareness, use and preference of health maintenance tables and algorithms amongst pcps and ed providers in nc and sc at project start and yearly across the project. additionally, the investigators will explore patient reported awareness of and satisfaction with co-management model of care in nc and sc. 3. the investigators will conduct an exploratory cost analysis of the dissemination and implementation of the scd co-management model and its effect on healthcare resource utilization.

Eligibility criteria:
inclusion criteria: * patient with diagnosis of sickle cell disease, emergency department clinician, or primary care clinician in the state of nc or part of sc exclusion criteria: * non-english speaking, non-resident of nc or sc

Keywords: co-management model of care primary care specialty care decision support tools emergency department clinicians co-management
interventions to improve hiv antiretroviral therapy adherence

Conditions: Human Immunodeficiency Virus (HIV) Infection

Summary: this study will explore whether financial incentives, reminders, information about hiv/aids and its treatment and anti-stigma counseling help improve anti-retroviral therapy (art) adherence among hiv infected individuals in a resource-limited environment. the interventions will be randomized in the study population in a cross-cutting design, with a control group, a financial incentive treatment group, a reminders treatment group, a treatment group that receives both the financial incentive and reminder interventions. in addition, there will be an information treatment group, a stigma-relieving treatment group and a group that receives both information and stigma-relieving interventions. the primary outcomes of interest for this study will be the adherence to art, measured by attendance rates at clinic appointments and refill collection rates.


Eligibility criteria:
inclusion criteria: * infected with hiv; * have not start art, or started art less than 90 days before; * have a phone number on which can discuss private health matters. exclusion criteria: * not infected with hiv; * on art for more than 90 days; * do not have a private phone.