Kornimate/medical-research-clean huggingface dataset:
correlation study of corneal nerve changes and dry eye in contact lens wearers

Conditions: Contact Lens Complication; Dry Eye

Summary: this study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(clade) patients and further discuss the role of corneal nerve in the genesis and development of clade.

33 daily disposable soft contact lens wearers with dry eye disease(ded), 33 ded without contact lens wear and 33 normal control subjects will be involved in study. one experienced ophthalmologist will evaluate the ded symptoms and signs, which include ocular surface disease index(osdi), tear film breakup time(tbut), schirmer ⅰ test, corneal fluorescein staining, lissamine green staining and meibomian gland dropout rate. after evaluating, corneal sensitivity are measured using a cochet-bonnet aesthesiometer. corneal nerve morphology will be assessed in the right eye using in vivo confocal microscopy(ivcm). fifteen to twenty minutes after ivcm, 20μl of basal tears will be collected from the inferior meniscus of each participant to test tear neuropeptides. then investigators analyse the correlation of corneal nerve changes and ded symptoms and signs.

Eligibility criteria:
inclusion criteria: * age 18years to 40 years； * male or female ded patients based on chinese dry eye diagnosis standard (2020) with or without contact lens wear； * provision of written informed consent. exclusion criteria: * presence of any of the following conditions: active ocular infection, ocular inflammation, active ocular allergy, ocular surgical history, laser treatment in the last 3 months, meibomian function (mgd) over grade 2 (the grade is according to the report of the international workshop on mgd in 2011), severe blepharitis or obvious inflammation of the eyelid margin, which in the judgment of the investigator may interfere with the interpretation of the study results * pregnant and lactating women, or those planning a pregnancy over the course of the study * uncontrolled systemic disease * suffer from diseases that may affect corneal nerves, such as keratoconus, trigeminal neuralgia, allergic conjunctivitis, etc.

Keywords: contact lens tear film dry eye corneal sub-basal nerve
collection of cerebrospinal fluid in healthy children

Conditions: Late Infantile Neuronal Ceroid Lipofuscinosis; Batten Disease

Summary: the purpose of this study is to obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at new york presbyterian hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (lincl), a fatal neurodegenerative disease.

obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at new york presbyterian hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (lincl), a fatal neurodegenerative disease.

Eligibility criteria:
inclusion criteria: * males and females, ages 2 yrs to 8 yrs * children already undergoing a lumbar puncture procedure for clinical or diagnostic purposes exclusion criteria: * presence of any significant neurological diseases, as judged by the co-investigators * presence of any significant medical conditions including cancer

Keywords: cerebrospinal fluid lumbar puncture spinal tap late infantile neuronal ceroid lipofuscinosis batten disease
metabolic fingerprinting

Conditions: Genetic Disease

Summary: the metaprint study aims to characterize the metabolic fingerprint of genetic diseases in order to enhance knowledge on the physiological disease status and establish so new tools for diagnosing, monitoring and personalizing treatment of genetic diseases.


Eligibility criteria:
inclusion criteria: * informed consent is obtained from the participant or from the parent/ legal guardian * the participant is 2 months or older * the participant is diagnosed with a genetic disease * the participant is a first degree relative of a subject diagnosed with a genetic disease exclusion criteria: * informed consent is not obtained from the participant or from the parent/ legal guardian * the participant is younger than 2 months * the participant is not diagnosed with a genetic disease * the participant is not a first degree relative of a subject diagnosed with a genetic disease

Keywords: metabolic fingerprint
optimization of golimumab treatment in ulcerative colitis

Conditions: Colitis, Ulcerative

Summary: this is a multicenter, prospective study of dose adjustment of golimumab in patients with ulcerative colitis who will initiate golimumab treatment (naïve to anti-tnf) or after failure (or exposure) to one anti-tnf, which aims to analyze serum golimumab levels and anti- golimumab antibody (ada) levels during the induction (week 6) and maintenance phases (week 14, 30 and 54) and correlate them with efficacy parameters.


Eligibility criteria:
inclusion criteria: * adult subjects (18 years or older, both sexes and any race) who will be treated with golimumab according to clinical criteria. exclusion criteria: * patients with crohn's disease or colitis pending classification * patients with ileoanal pouch * patients with perianal fistulas related to the disease * patients with a history of hypersensitivity to golimumab, other murine proteins, or to any of the excipients included in the golimumab datasheet. * patients with tuberculosis or other serious infections such as septicemia, abscesses and opportunistic infections. * patients with moderate or severe heart failure (nyha grade iii / iv)

Keywords: golimumab inflammatory bowel disease optimization drug levels anti-drug antibody levels
complete nerve-sparing radical hysterectomy for cervical cancer

Conditions: Cervical Squamous Cell Carcinoma; Cervical Adenocarcinoma; Malignant Neoplasm of Cervix Stage IB1; Stage IIA1 Cervical Cancer

Summary: the purpose of this study is to evaluate the feasibility of complete nerve-sparing type c1 radical hysterectomy in cervical cancer.

the primary objective of this study is to evaluate the rate of postvoid residual urine volume (pvr) \<50ml on postoperative day 4 in patients with stage ib1 and iia1 cervix cancer underwent complete nerve-sparing type c1 radical hysterectomy.

Eligibility criteria:
inclusion criteria: * age \>=18 years to \<= 70 years. * women with histologically confirmed, primary adenocarcinoma or squamous cell carcinoma of the uterine cervix. * stage iia1, or ib1 disease. * karnofsky performance status \>70. * patients who comply with follow-up. * with written informed consent. exclusion criteria: * age\>70 * history of lower urinary tract damage or surgery. * with abnormal urodynamic study results. * karnofsky performance status \<70. * patients who have uncontrolled psychological disorders. * unwilling to or unable to comply with protocol. * prior treatment with pelvic radiotherapy

Keywords: cervical cancer; nerve-sparing hysterectomy; simplified
effects of mind-body exercises in a patient with mood disorders: a case study.

Conditions: Mood Disorders; Mind-body Exercise

Summary: the interoception capacity may be changed with mind-body intervention. this study case investigated the interoceptive capacity, measured by maia scale of a pacient with mood disorders and if it can be influenced through of a 7 weeks intervention of interoceptive exercises and the impaction in the patient´s daily life. the aim was analyse the effects of mind-body exercise program with interoceptive approach in the anxiety and depression symptoms, interoceptive capacity, as well your impact in paitient's daily activities. m.s is 47 years old, was forwarded from university hospital clementino fraga filho to extension project named as "corpo\&mente" (body-mind), an anamnesis was performed including patient's life story, interoceptive scale, anxiety and depression scale from hamilton and a risk stratification to realize physical activities (it was also performed post-intervention). the exercise program lasted 1h 15 min and it was performed once a week.


Eligibility criteria:
inclusion criteria: * participants with anxiety or/and depression clinical diagnosis * participants who do not do formal meditation practices exclusion criteria: * participants with other diagnosis * patients with cognitive conditions
quality of life in elderly after aneurysmal subarachnoid hemorrhage (sah)

Conditions: Aneurysmal Subarachnoid Hemorrhage; Hydrocephalus; Cerebral Vasospasm

Summary: in all the western populations, the annual incidence of subarachnoid hemorrhage (sah) increase with age. in patients older than 70 years, the occurrence of sah exposes them to high risk of morbidity and a poor quality of life. in this age bracket, the single randomized which compared endovascular coiling to microsurgical clipping (isat study) showed that the relative risk of morbidity increased after coiling. moreover, some prospectives studies about endovascular coiling described favorable outcome in 48% to 63% of patients, complete occlusion in 51% to 69% and a procedural complication rate in 13% to 19%. from prospectives series, the proportion of favorable outcome after microsurgical clipping was estimated around 66% but the procedural complications are few reported. the outcome for patients treated conservatively was catastrophic. lastly, the hydrocephalus in this age class is common, occurring in 55% of patients. the study hypothesis is that, in this age class, no difference exists between the 2 obliteration procedures. an accurate evaluation of result in term of functional disability, quality of life and prognosis predictive factors seems a judicious question.

the aim of our study was to determine a significant difference in terms of functional disability between microsurgical clipping and endovascular coiling in the elderly population. randomized multicenter trial: 2 randomized arms (clipping and coiling) plus 3 observational prospective arms (clipping, coiling, conservative). inclusion time: 48 months. follow up: 12 months. monitoring: 6 months. duration of the trial: 66 months. major end point: proportion of patients with unfavourable outcome at 12 months (mrs \> 2). secondary end point: quality of life at 12 months (eortc scale), causes of morbidity (mrs \> 2) and mortality, dysautonomia according to the adl and iadl scales.

Eligibility criteria:
inclusion criteria: * 70 years old and more * subarachnoid hemorrhage in grade i-iv of wfns scale * ruptured cerebral aneurysm diagnosed on multislice computed tomography angiography or cerebral angiography * treatment of subarachnoid hemorrhage exclusion criteria: * patients in grade v of wfns scale * subarachnoid hemorrhage without cerebral aneurysm * patients with cerebral dementia, neurologic or psychiatric antecedents

Keywords: subarachnoid hemorrhage cerebral aneurysm elderly
laparoscopic roux-en-y gastric bypass and gastro-esophageal reflux

Conditions: Gastroesophageal Reflux; Obesity

Summary: laparoscopic roux-en-y gastric bypass (lrygb) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (ger). however, long term instrumental evaluations of ger after lrygb are not available. the aim of this study is to evaluate the long-term effects of laparoscopic roux-en-y gastric bypass (lrygb) on gastro-esophageal function.

consecutive morbidly obese patients selected for lrygb were included in a prospective study. the investigators performed clinical evaluation with gerd-hrqol and gis questionnaire, upper endoscopy, esophageal manometry and 24h-impedance ph monitoring (24h-mii-ph) preoperatively and at 12 and 60 months after surgery. patients were divided into 2 groups according to the presence of ger at preoperative 24h-mii-ph.

Eligibility criteria:
inclusion criteria: * history of obesity exceeding 5 years * documented previous weight loss attempts, * body mass index (bmi)) of 40-50 kg/m2 * age of 18-60 years. exclusion criteria: * contraindications to pneumoperitoneum * large esophageal hiatal hernia * pregnancy, * drug or alcohol abuse, * psychological disorders (e.g., bulimia, depression) * hormonal or genetic obesity-related disease * previous gastric surgery

Keywords: gastroesophageal reflux obesity esophageal manometry 24 h impedance ph-monitoring laparoscopic roux-en-y gastric bypass
hispanic community health study / study of latinos

Conditions: Cardiovascular Disease

Summary: the hispanic community health study / study of latinos (hchs/sol) is a multi-center epidemiologic study in hispanic/latino populations to determine the role of acculturation in the prevalence and development of disease, and to identify risk factors playing a protective or harmful role in hispanics/latinos.

study goals include studying the prevalence and development of disease in hispanics/latinos, the role of acculturation, and to identify risk factors that play protective or harmful roles in hispanics/latinos. the target population of 16,000 persons of hispanic/latino origin, specifically cuban, puerto rican, mexican, and central/south american, to be recruited through four field centers affiliated with san diego state university, northwestern university in chicago, albert einstein college of medicine in the bronx area of new york, and the university of miami. seven additional academic centers serve as scientific and logistical support centers. study participants aged 18-74 years underwent an extensive clinic exam and assessments to determine baseline risk factors. annual follow-up interviews will be conducted for 2-4 years to determine health outcomes of interest. study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. annual follow-up interviews will be conducted for 2-4 years to determine health outcomes of interest. study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level.

Eligibility criteria:
inclusion criteria: • hispanic/latino persons living in the us, aged 18-74 in four communities: san diego, bronx ny, chicago, and miami.examination of the cohort following a standardized protocol exclusion criteria: * plans to move from the region within 6 months. * unable to complete the study questionnaires in english or spanish. * women who are pregnant.

Keywords: cardiovascular disease hispanic latinos
lux-dx trends evaluates diagnostics sensors in heart failure patients receiving boston scientific's investigational icm system.

Conditions: Heart Failure

Summary: the primary objective of this study is to collect sensor data from insertable cardiac monitor systems.

the primary objective of this study is to collect physiological measurement data and heart failure (hf) event data that will be used to design and develop new diagnostic features for the insertable cardiac monitor (icm) systems. this study will not have pre-defined statistical endpoints. to support the primary objective, diagnostic sensor data will be compared to reference clinical testing data and heart failure decompensation events.

Eligibility criteria:
key inclusion criteria: * patient is currently in nyha class ii or iii. * for patients with lvef \>40% measured on most recent available echocardiography within the previous 12 months: * one (1) of the following echocardiography findings: la width (diameter) \>3.8 cm, la length \>5.0 cm, la area \>20 cm2, la volume \>55 ml, la volume index \>29 ml/m2, lvh defined by septal thickness or posterior wall thickness of \>1.1 cm and * one (1) of the following: elevated bnp/nt-probnp as defined by: bnp \>100 pg/ml or nt-probnp \>300 pg/ml within the previous 90 days for patients not in atrial fibrillation or bnp \>300 pg/ml or nt-probnp \>900 pg/ml for patients in atrial fibrillation at the time of screening for eligibility or documented heart failure hospitalization or unscheduled heart failure iv therapy in the previous 12 months * for patients with lvef \<40% (for mi patients, measured no less than 30 days post-mi) on most recent available echocardiography within the previous 12 months: * one (1) of the following: elevated bnp/nt-probnp as defined by bnp \>150 pg/ml or nt-probnp \>600 pg/ml within the previous 90 days for patients not in atrial fibrillation or bnp \>450 pg/ml or nt-probnp \>1800 pg/ml for patients in atrial fibrillation at the time of screening for eligibility or documented heart failure hospitalization or unscheduled heart failure iv therapy in the previous 12 months * patient is willing to be monitored in latitude clarity and use the icm patient mobile app. * patient is of legal age to give informed consent and is willing to participate in the trial. key exclusion criteria: * patient is currently implanted with any other active electronic medical device. * patient has undergone a heart transplant. * patient is currently enrolled in another investigational study (excluding registries) without prior written approval from boston scientific. * patient is known to be pregnant at the time of enrollment or plans to become pregnant during study participation. * patient is diagnosed with amyloidosis or hypertrophic cardiomyopathy.
study of the safety, tolerability, and pk of pra-027 administered to women of nonchildbearing potential

Conditions: Fibroid

Summary: the primary purpose of this study is to asess the safety and tolerability of ascending single oral doses of pra-027 in healthy women of nonchildbearing potential. the secondary purpose is to provide the initial pharmacokinetic (pk) and pharmacodynamic (pd) profile of pra-027 in healthy women of nonchildbearing potential, and to evaluate the effect of a high-fat meal on the pk and pd of pra-027 administered to healthy women of nonchildbearing potential.


Eligibility criteria:
inclusion criteria * women of nonchildbearing potential (woncbp) aged 18 to 60 years. must have a negative pregnancy test result within 48 hours before administration of test article. women who are surgically sterile must provide documentation of the procedure by an operative report or ultrasound scan. * body mass index (bmi) in the range of 18.0 to 30.0 kg/m2 and body weight ³50 kg. bmi is calculated by taking the subject's weight, in kilograms, divided by the square of the subject's height, in meters, at screening: bmi=weight (kg)/\[height (m)\]2 * healthy as determined by the investigator on the basis of screening evaluations. exclusion criteria * any significant cardiovascular, hepatic, renal, respiratory, gynecologic, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease. * a history of drug abuse within 1 year before study day 1, a history of alcoholism within 1 year before study day 1 or consumption of more than 2 standard units of alcohol per day (a standard unit equals 12 ounces of beer, 1½ ounces of 80-proof alcohol, or 6 ounces of wine). any positive findings during the urine drug screen for amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates. * use of any investigational or prescription drug within 30 days before test article administration. consumption of any caffeine-containing products (eg, coffee, tea, chocolate, or soda) or alcoholic beverages within 48 hours before study day 1. consumption of grapefruit or grapefruit-containing products within 72 hours before study day 1. use of any over-the-counter drugs, including herbal supplements (except for the occasional use of acetaminophen and vitamins ≤100% of the recommended daily allowance) within 14 days before study day 1.

Keywords: uterine leiomyomata (fibroids)
china adrenal disease registry

Conditions: Cushing Syndrome; Aldosteronism; Hypoadrenalism; Congenital Adrenal Hyperplasia; Adrenal Adenoma; Adrenal Incidentaloma; Adrenal Carcinoma; Pheochromocytoma

Summary: epidemiologic studies have revealed a tremendous increase in the prevalence of adrenal associated disease and related mortality worldwide. in order to meet all the therapeutic challenges in adrenal disease in china, case was founded in 2020. the objective of case is to launch an adrenal disease management model based on the internet health information platform which allows the application and evaluation of adrenal disease treatment strategies at multiple centers. the proprietary electronic medical database will help the dynamic big-data analysis in epidemiology of adrenal disease, diagnosis, and treatment.

in order to meet all the challenges in the diagnosis and treatment of adrenal diseases in china, case was founded in 2020. with advanced medical equipment and internet of things (iot) technology, case is committed to creating an online and offline integrated solution for adrenal disease, and for the entire spectrum of adrenal disease, to achieve a more convenient and precise model of care for patients, aiming to establish a platform with diagnosis and treatment of adrenal disease and their long-term follow-up. it allows the application and evaluation of treatment strategies at these centers.

Eligibility criteria:
inclusion criteria: 1. age ≥ 16 years old and ≤ 75 years 2. patients diagnosed with adrenal associated diseases, including cushing syndrome, primary aldosteronism, primary hypoadrenalism, congenital adrenal hyperplasia and adrenal adenomas, incidentalomas, and carcinomas, pheochromocytoma, etc. 3. provide written informed consent 4. satisfactory compliance exclusion criteria: 1. patients with significantly reduced life expectancy (less than 2 years) 2. with drug abuse 3. with aids or syphilis or infectious diseases such as viral tuberculosis in active phase at enrollment
long-term follow-up of anxiety and depression in patients with malignant tumors

Conditions: Malignant Tumor; Anxiety; Depression

Summary: this study was a single-center prospective, real-world observational study with plans to enroll all eligible patients. the basic information, anxiety and depression, treatment and prognosis of these patients were collected.

a total of 200 patients with malignant tumors will be enrolled in henan cancer hospital. this study is a single-center prospective real-world observational study, and all eligible patients are planned to be enrolled. the basic information, anxiety and depression, treatment and prognosis of these patients were collected.

Eligibility criteria:
inclusion criteria: 1. men and women of all ages are welcome. 2. pathological diagnosis of malignant tumor in our hospital. 3. received at least one hospitalization at this hospital. 4. the expected survival time is greater than 1 year. exclusion criteria: 1.there was no pathological report of malignancy.
magnetocardiography (mcg) device use in patients with elevated troponin

Conditions: ACS - Acute Coronary Syndrome

Summary: this prospective device study will examine the feasibility of mcg data collection in a hospital setting using the sandboxaq mcg device as a potential method to more accurately and quickly quantify cardiac disease of patients with elevated troponin.


Eligibility criteria:
inclusion criteria: * received a positive hs-ctni based on the institutions laboratory normal value ranges (e.g. female ≥14 and male ≥35) exclusion criteria: * present stemi * having an active atrial fibrillation episode as seen on 12-lead ecg * clear non-ischemic cause for symptoms (e.g. trauma) * active thoracic metal implants

Keywords: magnetocardiography mcg