Kornimate/medical-research-clean huggingface dataset:
acute biliary pancreatitis - optimal time for cholecystectomy

Conditions: Acute Biliary Pancreatitis

Summary: in patients with mild gallstone pancreatitis, early cholecystectomy within 48 hours might reduce the risk of recurrent gallstone-related complications, compared with the more commonly used strategy in our locality of conservative management and delayed cholecystectomy. however, evidence to support early cholecystectomy is poor, and concerns exist about an increased risk of cholecystectomy-related complications with this approach. in this study, we aimed to compare the benefits and harms of early versus delayed cholecystectomy in patients with mild biliary pancreatitis.

inclusion criteria 1. patient diagnosed with a first attack of mild biliary pancreatitis 2. age ≥ 18 years 3. american society of anesthesiologists (asa) grade i, ii or iii 4. a serum c-reactive protein (crp) concentration less than 100 mg/l, 5. no need for opioid analgesics, 6. normal oral diet tolerance exclusion criteria 1. chronic pancreatitis 2. alcohol abuse 3. pregnancy the number of patients needed was calculated. considering a power of 80% and reliability of 0.05, we found that 53 patients should be present in each group. eligible patients will be randomly divided into two equal groups (group 1: early cholecystectomy, group 2: delayed cholecystectomy) according to a computer-generated random numbers. procedure early cholecystectomy was done within 48 after admission. delayed cholecystectomy was done after 30 days after randomization. all cholecystectomies were done by, or under the direct supervision of, a surgeon who had undertaken at least 100 cholecystectomies in the past 5 years.

Eligibility criteria:
inclusion criteria: 1. patient diagnosed with a first attack of mild biliary pancreatitis 2. age ≥ 18 years 3. american society of anesthesiologists (asa) grade i, ii or iii 4. a serum c-reactive protein (crp) concentration less than 100 mg/l, 5. no need for opioid analgesics, 6. normal oral diet tolerance exclusion criteria: * 1. chronic pancreatitis 2. alcohol abuse 3. pregnancy
a study of dapsone gel in females with skin of color and acne vulgaris

Conditions: Acne Vulgaris

Summary: this study will evaluate the effect of dapsone gel in female subjects with skin of color (fitzpatrick skin types iv, v, and vi) with acne vulgaris.


Eligibility criteria:
inclusion criteria: * diagnosis of acne vulgaris * medium to dark complexion (fitzpatrick skin type iv, v or vi) * willing to avoid excessive or prolonged exposure of the face to ultraviolet light (eg, sunlight, tanning beds) throughout the study exclusion criteria: * received treatment with botulinum toxin of any serotype in the face within 6 months
the cost-effectiveness of hysterosalpingography versus hysterosalpingo-foam sonography during fertility work-up

Conditions: Infertility

Summary: hysterosalpingography (hsg) and hysterosalpingo-foam sonography are two methods to assess tubal patency during fertility work-up. this study aims to investigate the effectiveness of tubal flushing with oil-based contrast during hsg compared to tubal flushing during hyfosy in women undergoing fertility work-up. the hypothesis is that tubal flushing with oil-based contrast during hsg leads to more live births than tubal flushing during hyfosy.

background: the diagnostic work-up for infertility generally includes estimating the risk for tubal pathology and if indicated assessing tubal patency. traditionally, tubal patency testing during the fertility work-up is performed with hysterosalpingography (hsg). in previous studies it has been demonstrated that tubal flushing with oil-based contrast during hsg resulted in more ongoing pregnancies than when hsg is performed with water-based contrast. hyfosy is a more patient friendly alternative for hsg. up till now, the fertility enhancing effect of tubal flushing with exem foam during hyfosy has only been studied in relatively small and observational studies. objectives:the main objective of this study is to determine whether tubal flushing with oil-based contrast during hsg results into more pregnancies leading to live births when compared to tubal flushing with exem foam during hyfosy, and whether this approach is cost-effective. in this study the safety of both strategies will also be compared. rationale: the hypothesis is that tubal flushing with oil-based contrast during hsg leads to more live births compared to tubal flushing with exem foam during hyfosy in women with an indication for tubal patency testing. if more live births are achieved, expensive fertility treatments will be less needed, which makes tubal flushing with oil-based contrast during hsg a cost-effective strategy. study design: this study is a multicenter randomized controlled trial with an economic analysis alongside it. women with indication for tubal patency testing will be randomized to tubal flushing with oil-based contrast during hsg and tubal flushing with exem foam during hyfosy.

Eligibility criteria:
inclusion criteria: * infertile women or women with oligo-or anovulation * indication for tubal patency testing during the fertility work-up * sufficient understanding of the dutch or english language * signed informed consent exclusion criteria: * severe male factor with a total motile sperm count \<3x106ml (pre-washed) * known contrast (iodine) allergy * women who have had a gynecologic procedure within the last 30 days * women with known or suspected reproductive tract neoplasia

Keywords: hysterosalpingography hysterosalpingo foam sonography infertility work-up cost-effectiveness live birth randomized controlled trial
effects of pnf technique in children with post fracture elbow stiffness

Conditions: Fracture

Summary: daily living activities are an essential part of a child's development, providing endless opportunities for play, learning, and imaginative expression. the desired result as the child get bored after a while so we use it for benefits. proprioceptive neuromuscular facilitation is a stretching technique utilized to improve muscle elasticity and has been shown to have a positive effect on active and passive range of motions. in clinical settings, pnf is already utilized by therapists to restore functional range of motion (rom) and increase strength in patients who have sustained soft tissue damage or received invasive surgeries.

this randomized clinical trial study will be conducted in thq hospital arifwala/dhq pakpattan with calculated sample size 26. study will be approved by ethical committee. after that informed consent will be taken and patients will be randomly assigned to (group a) control group these individuals will receive maitland's mobilization with everyday object activities (group b) experimental group (these individuals will receive baseline treatment and pnf technique ) frequency will be 5 session per week of 30 min and duration is of 4 weeks. ranges will be assessed by goniometry dash outcome measure scale will use to assess functional activity. data will be analyzed by spss latest version.

Eligibility criteria:
inclusion criteria: * children age 3-7 years * either gender * contracture 4-8 weeks post traumatic injuries. * post-operative exclusion criteria: * burn contracture * contracture due to neurological conditions * dupytren's contracture, volkmann's contracture etc. * contracture more than 8 week
battlefield auricular acupressure (baapress) feasibility study

Conditions: Pain

Summary: the purpose of this research study is to find out what effects (good and bad) acupressure applied to the outside of the ear (auricular acupressure), in addition to the standard of care medication regimen, will have on pain. this study is being done to assess whether acupressure in addition to prescribed pain medication may be of benefit in decreasing pain levels and improving overall wellbeing. this study will also evaluate the feasibility of routinely offering acupressure to patients having pain issues in addition to a psychiatric diagnosis.

the purpose of this study is to test the feasibility of emergency department nurse-initiated battlefield auricular acupressure as an adjunct to medication for pain management for psychiatric emergency department observation patients. the battlefield auricula acupressure interventionists (nurse) will complete auricular training modules and complete competency assessments and intervention assessments throughout the study. study interventionist will include the possibility that a study participant may be part of a competency assessment and that their session may be recorded and securely uploaded to a server per institutional review board (irb) and institutional policies.

Eligibility criteria:
inclusion criteria: * patients requiring admission to psychiatric emergency room who also have documented chronic or acute pain * history of chronic or acute pain with or without opioid use disorder * expected length of stay at least 2-3 days at the time of recruitment * able to read and understand the informed consent form exclusion criteria: * since this is a feasibility pilot, only english-speaking participants will be eligible. * cognitive impairment (intellectual disability disorder or dementia) * patients who have a legal guardian * participants with a history of skin disease (e.g., psoriasis) involving the ear, adhesive allergy, recent scar tissue on ear, or current abrasions or cuts on ear, * use of some types of hearing aids (obstructing the placement of beads)

Keywords: auricular acupressure pain management acupressure seeds acute pain chronic pain
intraoperative ketamine versus saline in depressed patients undergoing anesthesia for non-cardiac surgery

Conditions: Major Depressive Disorder; Surgery; Orthopedic Disorder

Summary: this study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery. half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.

major depressive disorder (mdd) is widely prevalent among patients preparing to have surgery, and is a known risk factor for complications after surgery, including wound infection, myocardial infarction and opioid use disorder. ketamine has emerged as an effective, rapid-acting antidepressant therapy for patients with mdd, and may be a useful tool to prevent mdd-related morbidity in the perioperative period. ketamine has been well studied for mdd in outpatient clinics where it is given as an infusion (0.5 mg/kg over 40 minutes) in awake patients. ketamine is often used as part of an anesthetic cocktail in sedated or anesthetized patients, but it is unknown whether ketamine has an antidepressant effect in this context. the investigators will determine whether a ketamine infusion, compared to placebo (normal saline infusion), has an antidepressant effect when given during surgical anesthesia. if ketamine is an effective antidepressant in this population under anesthesia, its use could be incorporated into a set of interventions to minimize the perioperative complications associated with mdd.

Eligibility criteria:
inclusion criteria: * patient presenting for non-cardiac, non-intracranial surgery * major depressive disorder exclusion criteria: * pregnant of breastfeeding women

Keywords: depression ketamine anesthesia total joint arthroplasty
tolerability, safety and pharmacokinetics study of gx-30 in total thyroidectomy or near total thyroidectomy patients

Conditions: Total Thyroidectomy; Near-total Thyroidectomy

Summary: this study is designed as a combination of phase 1 (part a) and phase 2 (part b). the purpose of part a was to determine the safety, tolerability, and pharmacokinetics in patients with total thyroidectomy or near total thyroidectomy of gx-30 and it has been completed. the part b is currently recruiting and will investigate the efficacy and safety of gx-30 compared with thyrogen®.

recombinant human tsh was developed to provide tsh stimulation without withdrawal of thyroid hormone. radioiodine ablation and diagnosis with rhtsh became the standard of care treatment for patients with differentiated thyroid cancer. stably supplying rhtsh has been the unmet need for management and follow-up procedure for thyroid remnant. gx-30 is an investigational product, developed to provide inexpensive rhtsh to patients in order to ensure stable supply of rhtsh.

Eligibility criteria:
inclusion criteria: * subjects who voluntarily consented, after listing enough explanation for this study and investigational product. * minimum 19 years old. * minimum 50kg of body weight. * patients who had undergone total thyroidectomy or near total thyroidectomy due to differentiated thyroid carcinoma. * patient undergoing thyroid hormone administration. exclusion criteria: * thyroid cancer excluding differentiated thyroid carcinoma. * thyroidectomy excluding total thyroidectomy and near total thyroidectomy. * patients with heart, renal, or liver failure. * patients with ischemic stroke or the history of ischemic stroke. * smoker or ex-smoker with less than 3 months of stopping * patients with migraine or the history of migraine. * patients that the researchers do not think fit into the group, including patients failed in compliance assessment

Keywords: thyroid cancer thyroidectomy rhtsh gx-30
proteomic and physiological markers of exercise-induced physiological stress and fatigue in grand tour cycling

Conditions: Exercise Fatigue

Summary: this project aims to identify the effect of a 3-week grand tour (e.g. tour de france) on physiological markers and the blood proteome in world-class cyclists.

blood samples will be collected in world-tour cyclists in the fasted state (i) before, (ii) on the first resting day, (ii) on the second resting day, and (iv) on the final day of the tour de france. samples collected before and on the final day will be analyzed by proteomics, while sample from all timepoints will be assessed for specific cytokines to identify physiological markers of fatigue. in addition, questionnaires will be used to evaluate subjective feelings of fatigue and appetite.

Eligibility criteria:
inclusion criteria: * cyclist participating in the tour de france exclusion criteria: * younger than 18years old

Keywords: cycling proteomics grand tour
serum cytokine levels in patients with lumbal disc herniation and effectiveness of exercise

Conditions: Low Back Pain

Summary: the aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. patients who applied to hacettepe university hospitals physical medicine and rehabilitation department with low back pain complaints and were referred for treatment will be included in the study.

the aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. patients who applied to hacettepe university hospitals physical medicine and rehabilitation department with low back pain complaints and were referred for treatment will be included in the study. healthy individuals of similar age, height and weight will also be included for references to normal serum cytokine levels. all patients will be evaluated twice, before and 6 weeks after treatment. the treatment program will be applied 3 times a week for 6 weeks under the supervision of a physiotherapist.

Eligibility criteria:
inclusion criteria for patients with disc herniation: * diagnosis of disc herniation (protrusion, extrusion, sequestered disc) * not an indication for lumbar disc herniation surgery * for patients with neurological deficits, loss of strength, decrease in dtrs, loss of sensation and at least one positive slr test and presence of radicular pain * pain intensity of vas ≥ 3 * male and female patients between the ages of 20-55 inclusion criteria for heathy people * not having low back pain complaints in the past * female and male healthy individuals between the ages of 20-55 exclusion criteria: * systemic or inflammatory disease * pregnant or breastfeeding women * surgery of lumbar region * fracture of lumbar vertebrae * lumbar scoliosis * medication use for psychiatric disorders * tumor * allergy * neurological disease * alcohol-drug use * generalized musculoskeletal pain

Keywords: low back pain disc herniation stabilization exercises general exercises cytokines inflammation
proton mr spectroscopy of brain metastases in evaluation of treatment response.

Conditions: Neoplasm Metastasis; Lung Neoplasms; Breast Neoplasms; Melanoma

Summary: the aim of the study is to investigate the feasibility of in vivo single volume mr spectroscopy in evaluation of treatment response in patients with brain metastases, using 3t mr instrument. in order to optimize and avoid ineffective treatment of patients with brain metastases, in vivo mr spectroscopy can be an useful tool.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of brain metastases exclusion criteria: * children * pregnancy

Keywords: lipid choline metastasis magnetic resonance spectroscopy treatment response
selegiline in treatment of cocaine dependence - 2

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess selegiline as a pharmacotherapy for cocaine dependence.


Eligibility criteria:
please contact site for information.

Keywords: cocaine dependence selegiline
wellness achieved through changing habits (the watch study)

Conditions: Weight Loss; Obesity; Overweight

Summary: the purpose of this pilot, feasibility study is to investigate the acceptability of an acceptance-based therapy healthy lifestyle intervention in adolescent girls with overweight/obesity.

participants will attend 2 baseline clinic visits and adolescents will participate in an abt healthy lifestyle intervention. the intervention will include 15 sessions over 6 months. a post-treatment visit will occur.

Eligibility criteria:
inclusion criteria: * adolescent girls between ages 14-19 with overweight or obesity above the 85th percentile for sex and age as determined by cdc growth charts exclusion criteria: * known pregnancy or plans to become pregnant in the next 2 years * any condition prohibiting physical activity * a diagnosis of cardiovascular disease or diabetes * have active cancer or cancer requiring treatment in the past 2 years * have active or chronic infections (e.g., hiv or tb) * have active kidney disease or lung disease * an eating disorder or substance abuse disorder * having begun a course of or changed the dosage of any medications known to affect appetite or body composition within the previous 3 months * weight loss greater than or equal to 5% in the previous 6 months * if they do not follow the study plan

Keywords: acceptance-based therapy adolescents weight weight loss obesity overweight
lapatinib for brain metastases in erbb2-positive breast cancer

Conditions: Neoplasms, Breast

Summary: determine how safe and effective lapatinib is when used to treat patients with erbb2 overexpressing breast cancer that has spread to the brain and is still progressing there even after radiation treatment using wbrt (whole brain radiotherapy) or srs (stereotactic radiosurgery) to the brain. lapatinib is an oral drug that will be taken every day. tests for safety and efficacy will be performed every 4 weeks or 8 weeks (depending on the test) during the course of the study.


Eligibility criteria:
inclusion criteria: * signed informed consent * erbb2(her2)overexpressing breast cancer. * brain lesion(s) which are progressing. * prior treatment of brain metastases with whole brain radiotherapy (wbr)and/or stereotactic radiosurgery (srs). * prior treatment with trastuzumab (herceptin), either alone or in combination with chemotherapy. * cardiac ejection fraction(lvef)within the institutional range of normal as measured by echocardiogram. * able to swallow an oral medication. * adequate kidney and liver function. * adequate bone marrow function. exclusion criteria: * pregnant or lactating females. * conditions that would effect the absorption of an oral drug. * history of immediate or delayed hypersensitivity reaction to gadolinium contrast agents. * pre-existing severe cerebral vascular disease, such as stroke involving a major vessel. * serious medical or psychiatric disorder that would interfere with the patient's safety or informed consent.

Keywords: breast cancer brain metastases erbb2 positive her2 positive neoplasms cancer lapatinib lap016a2202 lap016a clap016a2202 gw572016
ipack block versus adductor canal block in high tibeal osteotomy

Conditions: Pain, Postoperative

Summary: a comparison between ipack block and adductor canal block in post operative pain management

two groups of patients between 40 and 60 yrs who are undergoing open wedge high tibeal osteotomy group 1 will receive ipack block with 15 ml bupivacaine, immediately before spinal anaesthesia . group 2 will receive adductor canal block ,also with 15 ml bupivacaine. before spinal anaesthesia. register the time of first pain sensation and firs iv analgesic dose required in each group

Eligibility criteria:
inclusion criteria: 1. age 40 - 60 years. 2. american society of anesthiologist class ( asa) i - iii 3. bmi 18-35 kg/m2 4. scheduled for primary unilateral open wedge high tibial osteotomy exclusion criteria: 1. known allergy to local anesthetics 2. contraindication to local anesthetics injection e.g. infection at the site of injection 3. contraindication to spinal anesthesia e.g. coagulopathy. 4. patients with pre-existing motor or sensory deficits in lower extremities. 5. insulin or noninsulin dependent diabetes mellitus. 6. systemic corticosteroid use within 30-days of surgery 7. difficulties in comprehending visual analog scale (vas) pain scores 8. history of arrhythmia or seizures 9. severe renal insufficiency