Kornimate/medical-research-clean huggingface dataset:
eye mask on sleep quality and tear layer function in patients with dry eye disease

Conditions: Dry Eye Disease

Summary: this randomized clinical trial (rct) was aimed to determine the effects of eye masking on sleep quality and tear layer function in patients with dry eye disease. in this regard, a total of 34 patients with dry eye disease aged between 20 to 35 years old will be participated. they will be randomly divided into case and control (n=17) groups. patients in the case group will be instructed to wear the eye mask as long as two weeks and the controls will be recommended to not wear it at the same time. afterwards, the eye mask application will be cross- over for the next 2 hours between the two groups. tear layer will be investigated in baseline and repeated in both follow- ups of weeks 2 and 4, either quantitatively and qualitatively, by using schirmer and tbut tests. furthermore, the sleep quality will be checked by the psqi test.


Eligibility criteria:
inclusion criteria: * patients with dry eye disease according to the osdi test exclusion criteria: * patients with eye disease except dry eye * patients using systemic and ophthalmic drugs * patients using sleeping and sedative pills
endocytoscopy for in vivo determination of mucosal inflammatory cells and intestinal disease activity in inflammatory bowel disease (ibd)

Conditions: Crohn´s Disease; Ulcerative Colitis

Summary: precise activity assessment of inflammatory bowel disease (ibd) is essential to determine the extent and severity of the disease for further specific therapy. nevertheless, despite ongoing developments in the field of gastrointestinal endoscopy, the final diagnosis still relies on the interpretation of histopathological features of intestinal biopsies taken during the endoscopic examination. recently, endocytoscopy (ec) was introduced as a new endoscopic imaging modality, enabling microscopic imaging within the mucosal layer of the gut at a magnification level of up to 1400-fold.


Eligibility criteria:
inclusion criteria: * written informed consent * age 18-85 years * ability of subjects to understand character and individual consequences of clinical trial * subjects undergoing colonoscopy * patients with known crohn´s disease or ulcerative colitis exclusion criteria: * inability to provide written informed consent * severe coagulopathy (prothrombin time \ 50 s) * impaired renal function (creatinine \> 1.2 mg/dl) * pregnancy or breast feeding * active gastrointestinal bleeding * known allergy to methylene blue or toluidine blue * residing in institutions (e.g. prison)
prognosis of depression in the elderly (prode). a multicentre, longitudinal study of elderly depressed patients.

Conditions: Depression; Dementia

Summary: prode is a norwegian multicentre study investigating the prognosis of depression in the elderly. the study has included 169 patients who will be followed with assessments after one and three years. the study hypothesis is that elderly patients referred to specialist health service have a poor long term prognosis.

objective: depression in the elderly is difficult to treat and is often of chronic or recurrent nature. there is little knowledge about the course and the risk factors for recurrence of depression among elderly people in norway. the aim of the prode-study is to examine the short- and long-term prognosis of elderly depressed patients who are referred for treatment in departments of old age psychiatry. method: prode is a multicentre case-control and longitudinal study of elderly (\>60 years) depressed and non-depressed patients with a one and three year follow-up. nine participating departments of old age psychiatry used the same standardized instruments to collect data of the patients on depression and other mental health issues, cognition, physical health, medications, functions in activities of daily living, quality of life and family carers' situation. the included patients and controls underwent an mri scan of the brain according to a comprehensive protocol developed for this project. furthermore, blood and saliva from the included patients are stored in a biobank for analyses of pro- and anti-inflammatory cytokines and cortisol. the study included 169 patients (december 2009-january 2013) and will include the same number of non-depressed controls. outcome measures (short-term): * depression as measured with the montgomery and asberg depression rating scale (madrs), cornell scale for depression in dementia (csdd) and hospital anxiety and depression scale (hads), trajectories and clinical assessments. * function in activities of daily living outcome measures (long-term): * cognition as measured by mini mental state examination (mmse) and diagnosis of dementia. * depression, recurrence of depression and as measured wtih the madrs and csdd. * use of health care facilities; nursing home. * mortality * function in activities of daily living

Eligibility criteria:
inclusion criteria: * patients with depression referred to treatment at specialist health care in norway. * patients above 60 years exclusion criteria: - demented patients with severe aphasia and patients with life threatening diseases will be excluded

Keywords: aged depression cognition longitudinal study
nav-ali: neurally adjusted ventilatory assist in patients recovering spontaneous breathing after acute lung injury

Conditions: Acute Lung Injury; Mechanical Ventilation

Summary: evaluation of a new ventilatory mode neurally adjusted ventilatory assist "nava" in patients who recover spontaneous breathing after acute lung injury.

physiological evaluation of two modes of mechanical ventilation: neurally adjusted ventilatory assist (nava) vs pressure support ventilation, at different levels of ventilator assistance. evaluation in term of physiological parameters: tidal volume, respiratory rate, inspiratory effort, paco2, evaluation of subject-ventilator synchrony. evaluation of physiological response to varying levels of ventilator assistance.

Eligibility criteria:
inclusion criteria: * age \> 18 years * hospitalized in intensive care unit * acute lung injury * intubated or tracheotomized and mechanically ventilated exclusion criteria: * hemodynamic instability * absence of consent

Keywords: nava acute lung injury pressure support ventilation intubation tracheostomy mechanical ventilation
the prognostic value of tertiary lymphatic structure in esophageal squamous cell carcinoma

Conditions: Esophageal Squamous Cell Carcinoma

Summary: retrospective analysis of the presence and maturity of tertiary lymphoid structures in pathological sections of patients with esophageal squamous cell carcinoma after surgical treatment. pay attention to the overall survival and disease free survival of these esophageal squamous cell carcinoma patients.


Eligibility criteria:
inclusion criteria: * 1. pathologically diagnosed as esophageal squamous cell carcinoma; 2. surgery for esophageal cancer; 3. complete medical records; exclusion criteria: * patients with a previous history of malignant tumor
novel portable diagnostic device for automatic detection of relative afferent pupillary defect

Conditions: Multiple Sclerosis; Glaucoma

Summary: this study is to evaluate the ability of a newly designed device, optic nerve glass (o-glass) to detect relative afferent pupillary defect (rapd). in this prospective study, 44 patients (diagnosed rapd- positive) enrolled the study. they were examined for an rapd by o-glass and also manual swinging flashlight method (sfm) . this newly designed instrument captures and records eye pictures. the images will be processed and analyzed using computerized software to calculate pupillary measurements.

pupil response to light stimulation is a basic clinical approach to the assessment of a patient with visual loss. asymmetric response may indicate a relative afferent pupillary defect (rapd). the rapid detection device for relative afferent pupillary defect (present device) is a newly designed portable facility with computerized software on a mobile device. this allows for field ophthalmic examination and identification of rapds quickly and accurately and also record pupillary movements for further processing and analysis or send the information and images via wi-fi. we aimed at comparing and evaluating this device with available methods to develop a test which is practically easy and quick with objective results and no need for specialist interpretation, so that any technician can perform the test automatically. distinctive software allows simple use of the device by field personnel with minimal training. each patient was investigated by swinging flashlight method and the newly constructed automated o-glass. the swinging flashlight test procedure, also called as marcus gunn test, is well known in ophthalmology science.the hardware for this device includes 4 different parts: camera and optics, light control system, power control system, and the microcontroller.the two main components of the software are the ability to communicate with the hardware wirelessly, and the pattern recognition system.

Eligibility criteria:
inclusion criteria: * positive relative afferent pupillary defect exclusion criteria: -

Keywords: relative afferent pupillary defect (rapd) multiple sclerosis glaucoma
use of fractional co2 laser for the treatment of vulvovaginal atrophy: a double-blinded randomized placebo-controlled clinical trial.

Conditions: Vulvovaginal Atrophy

Summary: purpose of the trial is to study the efficacy of fractional laser in alleviating genitourinary symptoms in menopausal women. primary outcome of the study is the efficacy of the laser procedure, intended as the amelioration of the severity of most bothersome symptom (mbs). therefore we conducted a single center, double-blinded randomized placebo-controlled cross-over trial.


Eligibility criteria:
inclusion criteria: healthy women with menopausal status (\>1 year amenorrhea) and with moderate to severe symptoms of vva as measured by the mbs score ≥2. exclusion criteria: * acute or recurrent urogenital infections * prolapse ≥ grade 3 according to the pelvic organ prolapse quantification system * hormonal replacement therapy within the last 6 months before study entry * use of local estrogens, moisturizers, lubricants or homeopathic preparations within the last 3 months * pelvic floor physiotherapy for pelvic floor disorders within the last 3 months * any condition that could interfere with study compliance
bortezomib in treating patients with relapsed or refractory hodgkin's lymphoma

Conditions: Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

Summary: phase ii trial to study the effectiveness of bortezomib in treating patients who have relapsed or refractory hodgkin's lymphoma. bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth.

primary objectives: i. to evaluate the efficacy of bortezomib in patients with relapsed or refractory hodgkin's lymphoma using overall response rate as the primary efficacy endpoint. ii. to assess time to progression and 2-year overall survival after bortezomib therapy. iii. to evaluate the safety and tolerability of bortezomib in patients with relapsed/refractory hodgkin's lymphoma. outline: this is a multicenter study. patients receive bortezomib iv over 3-5 seconds on days 1, 4, 8, and 11. treatment repeats every 21 days for up to 8 courses in the absence of rapid disease progression or unacceptable toxicity. patients are followed every 3 months for 1 year and then every 6 months for 2 years.

Eligibility criteria:
inclusion criteria: * histologically confirmed classical hodgkin's lymphoma * no bone marrow biopsies or fine needle aspirates as the sole means of diagnosis * core biopsies allowed if they contain adequate tissue for primary diagnosis * the following subtypes are allowed: * nodular sclerosis * lymphocyte rich * mixed cellularity * lymphocyte depletion * classical hodgkin's lymphoma, not otherwise specified * no nodular lymphocyte-predominant hodgkin's lymphoma * relapsed or refractory disease after at least 1 prior standard systemic cytotoxic chemotherapy regimen * measurable disease by physical exam or imaging studies * any tumor mass \> 1 cm is allowed * no non-measurable disease only, including the following: * bone lesions * ascites * pleural or pericardial effusion * lymphangitis cutis/pulmonis * bone marrow * no curative option available with high-dose therapy and stem cell transplantation * performance status - 0-2 * absolute neutrophil count ≥ 750/mm\^3 * platelet count ≥ 75,000/mm\^3 * bilirubin ≤ 1.5 times upper limit of normal (uln) * ast ≤ 2.5 times uln * creatinine ≤ 2.5 mg/dl * no sensory or motor peripheral neuropathy ≥ grade 2 * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception during and for up to 3 months after study participation * see disease characteristics * prior stem cell transplantation allowed * see disease characteristics * no concurrent chemotherapy * no concurrent dexamethasone or other steroidal antiemetics * concurrent steroids for adrenal failure allowed * concurrent hormonal therapy for non-disease related conditions (e.g., insulin for diabetes) allowed * prior radiotherapy to a symptomatic lesion or one that may produce disability (e.g., unstable femur) is allowed provided other measurable disease is present * no concurrent palliative radiotherapy * recovered from all prior treatment * no prior bortezomib or other proteosome inhibitors
quality control of ce-certified phonak hearing aids - 2017_37

Conditions: Hearing Loss, Sensorineural

Summary: phonak hearing systems pass through different development and study stages. at an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner. if the benefit is proven, their performance is then investigated regarding interdependency between all available algorithms, features and functions running in parallel in a hearing aid (pivotal/pre-validation studies) and, as a result, they get optimized. afterwards, and prior to product launch, the phonak hearing systems undergo a final quality control in terms of clinical trials. this is a pre-validation study, investigating optimized algorithms, features and functions. this will be a clinical evaluation which will be conducted mono centric at sonova ag headquarters based in stäfa (switzerland).


Eligibility criteria:
inclusion criteria: * adult hearing impaired persons (minimum age: 18 years) with at least 3 months experience with hearing aids * good written and spoken (swiss) german language skills * healthy outer ear * ability to fill in a questionnaire (p/ecrf) conscientiously * informed consent as documented by signature exclusion criteria: * contraindications to the md in this study, e.g. known hypersensitivity or allergy to the investigational product * limited mobility and not in the position to attend weekly appointments in stäfa (switzerland) * limited ability to describe listening impressions/experiences and the use of the hearing aid * inability to produce a reliable hearing test result * massively limited dexterity * known psychological problems * central hearing disorders
metabolic effects of honey in type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: this study aimed at evaluation of the metabolic effects of honey, as a supplemental food, in patients suffering from type 1 diabetes mellitus. a crossover design (two 12-weeks intervention periods) was used to measure honey effects. the subjects were randomized into two groups (intervention to control \[i/c\] and control to intervention \[c/i\] groups. each group consisted of 10 patients. . the subjects in the i/c group consumed 0.5 ml honey/kg/day in the first 12-week period (period 1) while the subjects in the c/i group did not receive honey as a control in period 1. after period 1 the subjects of each group exchanged their protocol for the following 12-week period (period 2).


Eligibility criteria:
inclusion criteria: * all patients with type 1 diabetes mellitus with their last hba1c less than 10% were candidates for this study. exclusion criteria: * coexisting renal or hepatic impairment * coexisting diseases e.g., malignancy, other endocrine disorders * patients on steroid therapy or other drugs that may affect the body weight or serum lipids.

Keywords: honey diabetes lipids c-peptide
coronary thromboaspiration and infarct size

Conditions: Ischemic Heart Disease; Acute Myocardial Infarction

Summary: distal embolization can occur during coronary angioplasty performed in the acute phase of myocardial infarction and is associated with poor long-term outcome. we hypothesize that the use of a system allowing thrombus aspiration before angioplasty and stent implantation will limit infarct size and its severity.

patients scheduled for emergency angioplasty in the acute phase of a first st-elevation myocardial infarction will be treated either by thromboaspiration followed by angioplasty or by angioplasty alone. the infarct size and severity will be assessed by ce-mri and rest tc99m-mibi gated spect performed during initial hospital stay (5th-8th day). a control mri will be performed at 6-month follow-up to analyse the evolution of left ventricular volumes.

Eligibility criteria:
inclusion criteria: * acute phase of myocardial infarction (\>48 hours from the onset of chest pain) * stable hemodynamic conditions * completely occluded infarct related artery exclusion criteria: * heart failure signs in the acute phase * contra indication for mri or spect imaging

Keywords: acute myocardial infarction thromboaspiration infarct size left ventricular remodelling
impact of an intervention education program on the knowledge, attitudes, and practices of dietitians

Conditions: No Conditions

Summary: this study aims to develop, implement, and evaluate an educational program-based intervention on the knowledge, attitude, and practice toward renal nutrition among dietitians working with chronic kidney disease (ckd) patients in public hospitals in saudi arabia. the study hypothesizes that there will be a significant improvement in the knowledge, attitude, and practice of renal nutrition among the dietitians in the intervention group compared to the control group after the implementation of the educational program. the findings will contribute to enhancing the ability of dietitians to provide effective nutritional care and support for ckd patients in saudi arabia.

a cluster randomized controlled trial will be conducted to evaluate the effectiveness of the intervention on the level of knowledge, attitude, and practice in renal nutrition competencies among the dietitians. a total of 100 participants (50 participants for each group) will be select using simple random sampling. the education intervention program will be developed based on the literature review of the guidelines for the nutritional management of ckd by looking into all evidence-based practice guidelines of renal medical nutrition therapy. the education intervention will include five weeks of in-person education sessions. the education intervention program will cover five lessons including nutrition assessment for ckd, malnutrition, macro- and micronutrients deficiencies in ckd, nutrition intervention and counselling skills. the education program will be delivered through lectures, workshops, brainstorming and case studies using materials such as powerpoints, videos, cards, posters, booklets and activities. the program will be offered online via zoom software, and the learners will have the materials to review at home. the program will be provided in close collaboration between the researcher and the hospital's nutrition department. data will be collected from four selected public hospitals in jazan city, saudi arabia, by direct interview of the dietitians in the hospitals to determine the competency assessment on knowledge, attitude, and practice of renal nutrition. all respondents in the hospitals will be evaluated before the start of the program (baseline evaluation), after the final intervention session (post-intervention evaluation), and three months after intervention (three-month follow-up after intervention). data will be analyzed by using the software statistical package for social sciences (spss) version 26.

Eligibility criteria:
inclusion criteria: * dietitians who worked with chronic kidney disease patients. * dietitians who registered in saudi commission for health specialties. * completed at least one-year experience in their job. * dietitians who agree to participate in the study. * dietitians who are available at the time of data collection. exclusion criteria: * medical doctor dietitians. * internship and student. * dietitians under one-year experience.
mulligan sustained natural apophyseal glides versus mckenzie method in patients with non-specific chronic low back pain

Conditions: Low Back Pain

Summary: low back pain (lbp) is the most frequent complaint encountered in clinical practice. exercises and manual therapy prescription are common physical therapy treatments prescribed for the patients presenting with chronic low back pain. the interventions will establish the future direction for practitioners in choosing the manual therapy or repeated exercises as effective prescription and provide a basis for future research

a variety of treatment interventions, modalities and techniques are used in physical therapy management of non-specific low back pain including manual therapy, exercises, neural mobilizations, stretching soft tissue techniques and dry needling etc. out of these more recent literature supports manual therapy, self exercises, patient counseling and awareness have been recommended in back pain management guidelines, in the united states and is also frequently used in clinical practice in various countries. despite multiple theoretical frame works proposing the role of snags and mdt mobilizations and exercises respectively, the literature on the true mechanism of direct or indirect physiological effects of these on performance or performance-related outcomes is vague and lacks justifiable procedural rigor. the results of this study will provide information regarding the direction for practitioners in choosing the manual therapy or repeated exercises as effective prescription and provide a basis for future research.

Eligibility criteria:
inclusion criteria: * patients of both genders * adult patents between the 20 to 45 years of age with chronic non-specific low back pain. * pain intensity of at least 3 or greater on 0-10 numeric rating scale. * modified low back pain disability questionnaire score equal to or greater than 20%. exclusion criteria: * serious underlying pathology with red flags. * patients having contraindication to physical exercises. * females with high parity. * pregnant or lactating females. * patients who participated in any type of rehabilitative training or exercise program for back pain in last 1 month. * spinal deformity or spinal stenosis. * history of fall or trauma to spine in last one year. * history of spinal, abdominal or hip surgery. * signs of nerve root compression with sensory, motor or deep tendon reflexes deficit. * serious underlying pathology with red flags. * systemic disease e.g., cardiovascular, metabolic or central nervous system. * osteopenia, osteoporosis. * medication's history (steroids, immunosuppressants, chemotherapy) * limb length discrepancy.

Keywords: non-specific low back pain sustained natural apophyseal glide mckenzie method mechanical diagnosis and therapy range of motion pain functional disability fear avoidance beliefs