Kornimate/medical-research-clean huggingface dataset:
a study of gw685698x 100mcg administered once daily either in the morning or the evening and gw685698x 250mcg administered once daily in the evening via diskhaler for 28 days in subjects with persistent bronchial asthma.

Conditions: Asthma

Summary: the purpose of this study is to compare the efficacy and safety of gw685698x 100mcg once daily either in the morning or the evening and gw685698x 250mcg administered once daily in the evening via diskhaler for 28 days in subjects with persistent bronchial asthma.


Eligibility criteria:
inclusion criteria: * outpatients aged between 16- 65 years. * male and female; female subjects must be non-child bearing potential or of childbearing potenetial with negative pregnancy test and willing to use acceptable contraceptive methods * documented clinical history of persistent asthma first diagnosed at least 6 months prior to visit 1 * currently receiving inhaled short-acting beta-2 agonists for symptom relief * a lung function of between 50 to 90% predicted (pef) * increase in pef of at least15%, 20 minutes after inhalation of 400mcg salbutamol exclusion criteria: * history of respiratory tract infection and/or exacerbation of asthma within a period of 4 weeks prior to visit 1 * history of life-threatening asthma, defined as an asthma episode that required intubation and/or was associated with hypercapnoea, respiratory arrest or hypoxia seizures. * a history of two or more asthma exacerbations requiring treatment with oral corticosteroids or hospitalisation in the 6 months before visit 1. * past or present disease that, as judged by the investigator, may affect the outcome of this study. these diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, haematologic disease, neurological disease, endocrine disease or pulmonary disease (including, but not confined to, chronic bronchitis, emphysema, bronchiectasis with the need of treatment, cystic fibrosis and bronchopulmonary dysplasia). * known or suspected sensitivity to corticosteroids, ventolin, or the constituents of rotadisks (e.g., lactose). * undergoing allergen desensitisation therapy. * neurological or psychiatric disease or history of drug or alcohol abuse that would interfere with the subject's proper completion of the protocol requirements. * is a current smoker or has a smoking history of 10 pack years or more (e.g., 20 cigarettes/day for 10 years). note: current smoker is defined as currently smoking or stopped smoking within 6 months of screening visit.
cervical carious lesions restored with calcium silicate based cement (biodentine) compared with glass-ionomer cement

Conditions: Gingivitis

Summary: this study will test if applying calcium silicate cements (biodentine) to restore cervical carious lesions might adversely affect the gingival health in comparison with conventionally used tooth colored material (gic)

the study will compare two different dental materials on dental lesions near the gum line. . the study will determine if one material is more effective in gingival health, after the placement of the two different dental materials.the oral hygiene and the gingival health of the restored teeth will be evaluated clinically at 1, 3 and 6-month intervals.

Eligibility criteria:
inclusion criteria: 1. good general health; 2. good oral hygiene; and 3. age range 18-60 years old. patients with the following criteria were excluded: 1. current smokers; 2. pregnant females; 3. or patient with periodontal diseases; and 4. those who had a history of poorly controlled diabetes, liver disease, malignancy, radiotherapy. exclusion criteria: 1. pregnant women 2. patients taking benzodiazepines, narcotics and multiple antidepressants for pain management not associated with the oral cavity 3. patients requiring treatment for more than 5 decayed sites, periodontal disease and root canal therapy 4. complicated medical history (\>4 concurrent treatment for systemic diseases) 5. lesion \>1mm below the gum line

Keywords: gingiva plaque pocket depth
clinical impact of eus in staging nsclc

Conditions: Non Small Cell Lung

Summary: the goal of this prospective study is to determine the clinical and economic impact of endoscopic ultrasound (eus) in staging nsclc. aims: 1) determine the accuracy of eus in staging nsclc 2) measure 5-year survival 3) measure quality of life in patients that undergo surgery 4) determine the cost benefit of eus in staging nsclc.


Eligibility criteria:
inclusion criteria: * any subject with presumed or known potentially resectable nsclc * due to the nature of nsclc, children (\<18 year of age) will not be considered * men, women, and minorities * subjects must be able to safely undergo conscious sedation for the eus procedure * subjects must be surgical candidates * subjects must not have an uncorrectable coagulopathy and must be able to refrain from the used of aspirin one week prior to the eus * patient must provide signed written informed consent exclusion criteria: * subjects with a history of previously treated lung, head \& neck, or esophageal cancer are not eligible if the histologic cell type is determined to be the same as what is biopsied during the eus-fna * uncorrectable coagulopathy * significant co-morbidities such as uncontrolled heart failure, or severe chronic obstructive pulmonary disease (copd) that would limit their survivability to surgery * evidence of significant active infection (e.g. pneumonia, peritonitis, wound abscess) * evidence of serious ongoing illness such as uncontrolled metabolic disease (diabetes mellitus, hypothyroidism, etc.) or cardiac condition * evidence of dementia or altered mental status that would prohibit the giving and understanding of informed consent, and no evidence of psychiatric illness that would preclude adequate compliance with this protocol

Keywords: non small cell lung
fixation of comminuted distal radius fracture

Conditions: Distal Radius Fracture

Summary: comparison between different methods in fixation of comminuted distal radius fractures

this clinical study aims at comparison of treatment outcomes of spanning plate versus spanning external fixator in fixation of comminuted distal radius fracture. the primary outcomes that we like to measure are pain, healing. stiffness and range of motion .

Eligibility criteria:
* inclusion criteria * skeletally mature patients aging 18 or more * comminuted distal radius fractures fernandez type v * exclusion criteria * age less than 18 year or more * patients with previous fracture affecting wrist joint in the same side. * parients with active infection in the affected joint * pathological fracture * neurological disorder (epilepsy...etc) reheumatoid

Keywords: distal radius fracture
electronic monitoring and improvement of adherence to doacs in polymedicated stroke patients

Conditions: Adherence, Patient; Stroke, Ischemic

Summary: primary objective of the maaestro trial is to evaluate the impact of an educational and reminder-based intervention on the adherence of stroke patients to doacs. secondary objectives are to evaluate the association between non-adherence and clinical events, to identify predictors of non-adherence and to compare objective measures of adherence with self-reporting. key methodological instrument for this study will be the "time4med" pillbox with smart/ reminder card. the study includes 3 visits (baseline visit 0, follow-up visit 1 and end-of-study visit 2) with a total follow-up of 9 months. after an initial 3-month observational phase with electronic monitoring of adherence using the "smart card", all patients will receive counselling based on their electronically recorded drug intake data, as well as a multicompartment pillbox. patients will be then randomised to one of two groups in a crossover design, so that in the subsequent 6-month interventional phase one group will use a (reminder-delivering) "reminder card" for the first 3 months and the "smart card" for the last 3 months, while the second group will use the cards in reverse order.


Eligibility criteria:
inclusion criteria: * signed informed consent form (icf) * adult patients (≥ 18 years) * hospitalization for acute ischaemic stroke (including tia with positive neuroimaging) * doac treatment for atrial fibrillation or embolic stroke of undetermined source * patients receiving polypharmacy, defined as at least 3 drugs (including doac treatment) * patients self-administering their medication * patients already using a pillbox or willing to use one exclusion criteria: * patients not able or unwilling to sign icf * medication administration by caregiver - filling of the pillbox by a pharmacy, relatives or other caregivers does not exclude the patients, provided that they self-administer their medication * patients who are, in the opinion of the investigator, unlikely to adhere to the study schedule or are unsuitable for any other reason

Keywords: ischemic stroke, direct oral anticoagulants, adherence, electronic monitoring, adherence-improving intervention, polypharmacy
levosimendan versus dobutamine in cardiopatic patients undergoing major non cardiac surgery

Conditions: Cardiovascular Diseases

Summary: this study wants to investigate the hemodynamic changes in cardiopatic patients undergoing major non cardiac surgery, during and after the continuous infusion of levosimendan or dobutamine.


Eligibility criteria:
inclusion criteria: * ef \< 40%, no liver and renal disfynction, chronic cardiopathy exclusion criteria: * acute coronary syndrome, life expectation \<30 days, hemodialysis, ventricular tachycardia/ventricular fibrillation
postoperative neuroinflammation and cognitive dysfunction after abdominal surgery

Conditions: Anesthesia; Surgery; Neurogenic Inflammation; Cognitive Disorders

Summary: the main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia

the investigators aim to study immune cell activation as a biomarker for neuroinflammation using the cell specific \[11c\]pbr28 probe as detected by pet imaging techniques.

Eligibility criteria:
inclusion criteria: 1. patients 60-75 years of age. american society for anesthesiologist' criteria (asa) physical status i-iii 2. lower abdominal surgery (hysterectomy/prostatectomy) under general anaesthesia 3. obtained consent within 3 months before execution of the study. exclusion criteria: 1. patient's refusal to participate in the trial 2. ongoing smoking, snuff or other nicotine compound treatment 3. disabling neuropsychiatrical disorder (a mini mental state examination (mmse) score ≤ 24, diagnosis of dementia, mb alzheimer, mb parkinson, schizophrenia, or mental depression) or other signs of significant cognitive decline. 4. history of stroke with neurological sequelae 5. surgical procedure scheduled for regional anaesthesia. 6. severe cardia and/or renal and/or hepatic impairment. 7. coagulopathy. 8. terminal phase of a chronic disease. 9. patient on steroidal or non-steroidal anti-inflammatory drugs. 10. admission b-glucose \> 15 mmol/litre or poorly controlled diabetes mellitus. 11. presumed uncooperativeness or legal incapacity. 12. preoperative or later postoperative b-hemoglobin \< 90 g/l.

Keywords: neuroinflammation postoperative cognitive dysfunction
prospective maternal surveillance of ssa (sjögren syndrome a) positive pregnancies using a hand-held fetal heart rate monitor

Conditions: Sjogren's Syndrome; Neonatal Systemic Lupus Erythematosus; Fetal Heart Block Complete

Summary: the purpose of the research study "heart sounds at home" is for pregnant ssa or ssa/ssb (sjögren syndrome b) antibody positive mothers to use a doppler fetal heart rate monitor to detect abnormal heart rates and rhythms in their babies before they are born.

the study will enroll mothers during week 16-19 of gestation and will ask the mothers to use a hand-held doppler monitor to listen to the baby's heart rate and rhythm twice daily from about week 16 to week 26 of the pregnancy. pregnant mothers will be asked to keep a log of the heart rates and will undergo a fetal echocardiogram every 2 weeks during their study participation. in addition to these procedures, the study team will collect the mother's medical and obstetrical histories. should irregular heart rhythms be detected at home, the mother will contact the investigator to be evaluated. after the baby is delivered, the study team will collect information about the baby's birth and heart rhythm evaluation (electrocardiogram).

Eligibility criteria:
inclusion criteria: * pregnant women with positive ssa or ssa and ssb antibodies * gestational age (ga) between 16 and 19 weeks * no signs of antibody-mediated fetal cardiac disease on pre-enrollment echo exclusion criteria: * subjects who are more than 19 weeks gestation * subjects who have a fetus with an estimated fetal weight below the 10th percentile will also not be included

Keywords: neonatal systemic lupus erythematosus sjogren's syndrome fetal atrioventricular block fetal heart block
cryoballoon and associated esophageal effects

Conditions: Atrial Fibrillation

Summary: the primary objectives are to determine the correlation between rate of temperature decline and nadir cryoballoon temperatures rate of temperature decline and nadir esophageal temperatures during pulmonary vein isolation. to accurately measure the distance between the esophagus and the ostium of each pulmonary vein intra-operatively. to attempt to create recommendations for esophageal temperature-guided ablation in order to increase the safety profile of cryoballoon pulmonary vein isolation (pvi) by providing one center's experience. by trending cryoballoon ablation temperatures and subsequent esophageal temperatures, data trends may emerge and be predictive for esophageal ulceration formation. these trends may include: * distance between esophagus and pulmonary vein in patients who developed post-ablation esophageal ulcerations * intra-procedure esophageal temperatures in patients who developed post-ablation esophageal ulcerations * intra-procedure cryoballoon temperatures in patients who developed post-ablation esophageal ulcerations as well as to associate the development of symptoms (including dysphagia, chest pain, fever, "heartburn," or odynophagia) with the presence of ulcerations.

when treating atrial fibrillation and targeting various areas in the left atrium, electrophysiologists have the choice to perform ablation with rf energy or cryoenergy. esophageal ulceration and in more rare cases, esophageal fistulae, are known complications of this ablation procedure. though rare (0.1-0.25% fistula rate and 15-20% esophageal ulceration rate according to the most recent heart rhythm society ehra eca consensus statement)1, the investigators would very much like to understand how to completely prevent these occurrences. cryoenergy has more recently been introduced as an energy source used in the pvi procedure; therefore, for this energy source, rates of esophageal ulceration are not yet well-defined. nine esophageal fistulae have occurred in the first approximately 130,000 cryoballoon procedures.

Eligibility criteria:
inclusion criteria: 1. recurrent, symptomatic, drug-refractory, paroxysmal atrial fibrillation with planned cryoballoon pulmonary vein isolation 2. age \>18 years 3. planned af cryoablation procedure exclusion criteria: 1. la diameter \>55mm 2. severe lvh (lv wall ≥ 15mm) 3. la thrombus 4. decompensated heart failure 5. plans for left atrial ablation lesions beyond isolation of the pulmonary veins 6. history of previous pulmonary vein isolation 7. inability to place esophageal temperature probe or tee probe 8. previously documented phrenic nerve injury 9. known esophageal pathology (complete gi history worksheet)
evaluation of the relationship between the duration of the evolution of the complex regional pain syndrome type 1 (crps 1) and effectiveness of the continuous peripheral nerve block (cpnb) associated with an intensive rehabilitation program

Conditions: CRPS (Complex Regional Pain Syndrome) Type I

Summary: the study evaluates the relationship between the duration of evolution of sdrc1 and the efficacy of continuous peripheral nerve block (c-pnb) associated with an intensive rehabilitation program to improve the therapeutic strategy of sdrc1. the main hypothesis of this study is that if c-pnb is proposed earlier, the recovery, measured with a scale achievement of objectives, will be better.


Eligibility criteria:
inclusion criteria: * informed consent signed * diagnosis of crps type 1 according to budapest criteria to the upper or lower limb * affiliated to a social security scheme (beneficiary or entitled person) * patients justifying the installation of a continuous peripheral nerve block (cpnb) including pain rebellious to physical and medicinal treatments, the presence of fixed dystonia, or kinesiphobia or who are no longer progressing in the rehabilitation algorithm and requiring the need for a specialised technical platform. exclusion criteria: * crps type 2 * contra-indication to the analgesics used (bupivacaine, ropivacaine, levobupivacaine) * severe psychiatric decompensation * under legal protection measures * pregnant women
effect of boswellia sacra as an intracanal medicament on postoperative pain intensity and bacterial load reduction

Conditions: Intervention

Summary: this research will study the effect of boswellia sacra versus calcium hydroxide as an intracanal medicament on postoperative pain intensity measured using numerical rating scale (nrs) and bacterial load reduction reduction determined by bacterial counting using agar culture technique after root canal preparation (cfu/ml) in mandibular premolars with necrotic pulp.

primary outcome postoperative pain measured using numerical rating scale (nrs) 1. after placement of intracanal medicament at 6, 12, 24 and 48 hours. 2. after root canal obturation at 6, 12, 24 and 48 hours. secondary outcomes bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (cfu/ml) . 1. sample 1 (s1): after access preparation and pre-instrumentation. 2. sample 2 (s2): post-instrumentation. 3. sample 3 (s3): post-intracanal medicament removal at 3 or 7 days according to the group.

Eligibility criteria:
inclusion criteria: 1. age between 25-45 years old. 2. males or females. 3. healthy patients whom are categorized as i or ii according to the american society of anesthesiologists. (asa i or ii) 4. patients' accepting to participate in the trial. 5. patients who can understand pain scale and can sign the informed consent. 6. mandibular single rooted premolars, having single root canal: * diagnosed clinically with pulp necrosis. * absence of spontaneous pulpal pain. * positive pain on percussion denoting apical periodontitis. * periapical radiolucency not exceeding 2\*2 mm radiographically. * normal occlusal contact with opposing teeth. exclusion criteria: 1. medically compromised patients having significant systemic disorders (asa iii or iv). 2. if analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 3. pregnant women: to avoid radiation exposure, anesthesia, medication and hormonal fluctuation that might increase pain prevalence. 4. patients reporting bruxism, clenching, tmj problems or traumatic occlusion: to avoid further pressure on inflamed tooth which induce subsequent irritation and inflammation. 5. patients with two or more adjacent teeth requiring endodontic treatment. 6. teeth that requires further procedural steps or multidisciplinary approach, which is out of this experiment's scope: i. association with swelling or fistulous tract. ii. acute periapical abscess. iii. mobility grade ii or iii. iv. pocket depth more than 5mm. v. previous root canal treatment. vi. non -restorable vii. immature roots viii. radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification. 7. inability to perceive the given instructions.
laser therapy for venous leg ulcers

Conditions: Venous Leg Ulcer; Varicose Ulcer; Stasis Ulcer

Summary: this randomized controlled trial will evaluate the effects of high-intensity laser therapy on wound healing in patients with venous leg ulcers. participants will be randomly assigned to receive either laser therapy plus standard care or standard care alone. the laser therapy will be administered 3 times per week for 8 weeks or until ulcer closure. the primary outcome is proportion of participants with complete ulcer closure.


Eligibility criteria:
inclusion criteria: 1. male or female patients aged 18 years up to 65 years. 2. presence of a venous leg ulcer, confirmed by clinical examination and doppler ultrasound (venous reflux \> 0.5 seconds). 3. ulcer size between 1 cm² and 20 cm² at screening. 4. ulcer duration of at least 4 weeks but not more than 12 months. 5. ankle-brachial index (abi) ≥ 0.8, assessed by doppler ultrasound. 6. willing and able to provide informed consent and comply with study procedures. exclusion criteria: 1. presence of an active infection in the ulcer, confirmed by clinical signs and positive culture results. 2. osteomyelitis, diagnosed by radiographs or magnetic resonance imaging (mri). 3. patients with a history of uncontrolled diabetes, defined as hba1c level \> 10%. 4. current or planned use of systemic immunosuppressive drugs or corticosteroids during the study period. 5. pregnant or breastfeeding women. 6. patients with a history of malignancy or photosensitive skin disorders. 7. prior history of skin grafting or flap surgery in the affected area within the past 3 months.
the beijing adult dry eye cohort study

Conditions: Dry Eye

Summary: to investigate the prevalence of dry eye in adults in beijing, and explore the extremely dangerous factors of dry eye in adults in beijing through two years follow-up, and establish a prediction model of dry eye; on this basis, the prevention and treatment strategy of dry eye disease suitable for chinese people is put forward, and its actual effect is verified.

specifically, it is planned to carry out cluster random sampling in jianguomen community, yongdingmenwai community, and jiaodaokou community in dongcheng district, beijing, and select adults over the age of 18 to enter the queue for observation; in order to ensure the accuracy of the prevalence survey, people with mobility difficulties or mental problems are not excluded. the subjects will be examined by ophthalmology and osdi questionnaire to determine whether these people have dry eyes. then the prevalence of dry eye would be expolored. then through one-year and two-year follow-up, the incidence would be explored.

Eligibility criteria:
inclusion criteria: * aged 18 or above, resident population of sample community, able to complete dry eye examination, informed consent signed exclusion criteria: * mental illness, mobility difficulties, can not participate in follow-up

Keywords: prevalence incidence risk factor dry eye adult
set volume of optimal resistance exercise to generate hypotension

Conditions: Hypertension; Post-Exercise Hypotension; Resistance Training

Summary: this study evaluates the volume of optimal resistance exercise to generate postexercise hypotension after performing a single exercise in hypertensive elderly subjects. 20 subjects will perform 1 control session and 3 resistance training sessions with different volume: 3, 6 and 9 sets


Eligibility criteria:
inclusion criteria: * hypertensive subjects treated with antihypertensive medication * controlled blood pressure * age between 55 and 70 years old * sedentary (less than 150 minutes per week of moderate physical activity and/or 75 minutes per week of vigorous physical activity) * non-smokers * non-alcoholics * informed consent exclusion criteria: * any kidney, lung, neurological or psychiatric disease * unable to perform exercises * participation in other physical activity programs during the study or in the previous 3 months