Kornimate/medical-research-clean huggingface dataset:
effect of highly bioavailable curcumin on subjective tinnitus

Conditions: Tinnitus, Subjective

Summary: this study will assess the effectiveness of highly bioavailable curcumin in suppressing subjective tinnitus based on pre- and post-treatment evaluations using the validated tinnitus functional index (tfi) and tinnitus handicap inventory (thi) surveys.

subjects with severe, subjective tinnitus due to sensorineural hearing loss will complete both tfi and thi surveys prior to starting therapy. subjects will then be randomized to a treatment or placebo group. the treatment group will be provided with a supply of capsules containing 500 mg of curcumin-phosphatidylcholine combined with 250 mg of boswellia-phosphatidylcholine, which increases curcumin bioavailability. subjects in the treatment arm will be instructed to take 1 capsule by mouth twice daily for 30 days. placebo group subjects will be provided with a placebo compound with instructions to take the same number of capsules by mouth for the same period of time. both the active compound and the placebo will be provided by smartceuticals, inc (910 w. van buren st. ste 100-376 chicago, il 60607) to the outpatient pharmacy at ascension providence park (novi, mi), which will be responsible for storage, distribution and tracking. after 30 days, patients will be asked to return bottles to the pharmacy with any unused capsules to confirm and monitor compliance. placebo and active agent capsules and bottles will be identical in appearance with the exception of a unique alphanumeric code on the bottle label that identifies whether the distributed capsules contain active agent or placebo. this code will be matched to the participating subject by the pharmacy and will be used at the end of the study to determine which treatment arm each subject was in. to facilitate blinding, the master list of alphanumeric codes will be maintained by the manufacturer. at the completion of therapy, subjects from both groups will re-take the tfi and thi.

Eligibility criteria:
inclusion criteria: * adults with subjective tinnitus due to sensorineural hearing loss as determined by routine audiogram. exclusion criteria: * adults with subjective tinnitus due to another cause * sensitivity or allergy to test compounds * use of other off-label medications, substances, treatments specifically for tinnitus mitigation (e.g., anti-depressant/anxiety medications, gaba-inhibitors, psychiatric-based interventions/counseling) * pregnancy * patients taking anticoagulants to minimize risk of drug-drug interactions.

Keywords: curcumin anti-inflammatory compound turmeric
bone mineral markers in hypogonadism

Conditions: Hypogonadotropic Hypogonadism; Endothelial Dysfunction; Insulin Resistance

Summary: the aim of this study is to investigate the markers of bone mineral metabolism in an unconfounded group of patients with hypogonadism and to search for a relationship between endothelial dysfunction and insulin resistance.

cardiometabolic disorders are prevalent in patients with hypogonadism. endothelial dysfunction and insulin resistance are used in determining cardiovascular risk. the role of markers of bone mineral metabolism in hypogonadism is not clearly presented. 49 male patients with hypogonadotropic hypogonadism (hh) and 43 bmi and age matched healthy male subjects were enrolled. osteoprotegerin (opg), fibroblast growth factor-23 (fgf-23), vitamin d and asymmetric dimethylarginine (adma) levels were measured. the insulin sensitivity was estimated by homeostatic model assessment-insulin resistance (homa-ir) formula.

Eligibility criteria:
inclusion criteria: * male patients with hypogonadotropic hypogonadism * being under the age of 45 and over the age of 18 * not previously given testosterone or human chorionic gonadotropin therapy * not have any chronic metabolic disorders or organ dysfunction exclusion criteria: * female patients * other reasons hipogondism * receive any treatment of hypogonadism * presence of comorbid diseases

Keywords: hypogonadism asymmetric dimethyl arginine osteoprotegerin fibroblast growth factor vitamin d
supporting primary care in diagnosis and choice of treatment for patients with psychosocial symptoms: sgepsyscan.

Conditions: Mental Disorders

Summary: although effective treatments for psychosocial symptoms and disorders are available, patients frequently do not receive the most appropriate and effective treatment for their symptoms because of inappropriate and unstructured diagnostics of psychosocial symptoms in general practice. the hypothesis is that by using the intervention sge-psyscan the clinical symptoms of patients can be assessed more uniformly and earlier as opposed to the gps' assessment in usual care. as a result, patients are supposed to start earlier with a treatment that fits the type and severity of their symptoms better. the patients will be randomly assigned to either receive the sge-psyscan or usual care.


Eligibility criteria:
inclusion criteria: * patients with (suspected) psychosocial symptoms * aged 18 years or older and capacitated * adequate understanding of dutch language * able to perform sge-psyscan at home, individually exclusion criteria: * clear and treatable somatic causes of symptoms * acute distress/danger * no written informed consent
implementation of an efficacious intervention for high risk women in mexico

Conditions: HIV; Syphilis; Gonorrhea; Chlamydia

Summary: this project seeks to determine the personal and organizational conditions that are most conducive to the widespread adoption by community-based organizations (cbos) of effective programs for reducing the spread of hiv and other sexually transmitted infections (stis). taking a brief, single-session counseling program (called "mujer segura") that has been proven effective in reducing hiv and stis in female sex workers who work in mexican cities along the u.s. border, this project will study the implementation of the program in cbos in 12 additional cities throughout mexico to determine how best to ensure that the program remains true to the original model and retains its effectiveness. mexico has been chosen because hiv is a global problem that respects no international borders, and because hiv prevention programs that can be implemented in settings with limited resources are urgently needed in many parts of the world.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * self-identify as female sex worker * exchanged sex for money, drugs, shelter, or other benefit in last 2 months * had unprotected anal or vaginal sex with male client at least once in last 2 months * agree to be tested for hiv \& stis at baseline and 6-month follow-u0 exclusion criteria: * previous positive hiv test result

Keywords: condom use
evaluation of strategies for improving ketogenic diet compliance

Conditions: Epilepsy; Ketogenic Dieting; Compliance, Treatment

Summary: in order to increase adherence to ketogenic diet treatment, palatability of meals and diversify the foods offered to patients a ketogenic kitchen will be created. intervention: incorporation of culinary workshops and supply of recipes for patients undergoing ketogenic diet treatment at instituto da criança - hcfmusp.

introduction: the ketogenic diet is a therapeutic option for the control of drug-resistant epileptic seizures. it is based on high fat consumption, protein control and carbohydrate restriction. as a result, the body uses fat as an energy substrate instead of glucose. changing the patient's daily menu and eating routine is hard and requires dedication from the caregiver for the best therapeutic result. in clinical practice, the diet becomes monotonous and poorly accepted by the patient over time. besides, there is a difficulty in understanding nutritional guidelines. it is necessary to develop strategies to increase adherence to treatment, palatability of meals and diversify the foods offered to patients. objective: to evaluate the effectiveness of creating a ketogenic kitchen in improving compliance of patients with cd in the outpatient clinic of instituto da criança - hcfmusp. methods: this work will be carried out in 4 steps: (1st) creation and validation of a questionnaire of ketogenic diet compliance, (2nd) creation of ketogenic recipes of easy preparation and low cost, (3rd) incorporation of culinary workshops and supply of recipes for patients undergoing treatment at instituto da criança - hcfmusp and (4th) application of the questionnaire of ketogenic diet compliance.

Eligibility criteria:
inclusion criteria: * patients 0 to 18 years old; * clinical indication of a classic ketogenic diet; * predominantly oral feeding. exclusion criteria: * patients using exclusive gastrostomy; * patients with other types of kd than classical kd.
environmental and sensory intervention for nursing home residents with dementia who exhibit persistent vocalizations

Conditions: Dementia

Summary: the purpose of this study is to test a person-centered, nature-based non-pharmacological intervention for nursing home residents living with dementia who exhibit persistent vocalizations. the environmental and sensory experience (ease) involves the projection of a still nature image and the playing of nature sounds. family members of the person living with dementia provide consent for the resident to participate in the study and complete a brief survey on nature preferences on the resident's behalf. the survey informs the research team on what nature scene to show. participants will wear a watch that measures stress levels and research staff will monitor vocalization patterns. we will also recruit persons living with dementia from other settings such as assisted living, personal care units, and adult day care settings.

after enrolling in the study, participants will participate in three study visits. during the first two visits, study personnel will observe the nursing home resident to collect data on the resident's vocalizing behaviors (persistent vocalizations, pvs). these visits will last for roughly six hours, one during the day shift and one during the evening shift. the third visit will last approximately 90 minutes. during this visit, study personnel will observe vocalizing behaviors before, during, and after the ease intervention is in use. residents will also wear a watch for all three visits that records information about their heart rate and stress levels. all visits will occur in the resident's natural environment- either their room or common space and will be scheduled at the convenience of the resident and nh staff. the aims of the study are: aim 1: examine the feasibility and preliminary efficacy of the ease to reduce pvs among nh residents. aim 2: evaluate the nh staff perception of the acceptability of the ease within 48 hours post-intervention. aim 3: examine the mechanism of action of the ease.

Eligibility criteria:
inclusion criteria: * the participants must: 1) have a medical diagnosis of dementia; 2) have severe dementia as determined by a mmse score of ≤9 (or another cognitive test indicating severe dementia); 3) have a history of pvs per staff report; 4) be 50 years older or greater; 5) require extensive assistance by staff to ambulate or is non-ambulatory (to allow for consistent video recording). in addition, consent will be obtained from the resident's legally authorized representative (lar) and assent from the participant. exclusion criteria: * persons living with dementia will be excluded if they: 1) are blind; 2) are deaf; 3) give indications of dissent. variations will be sought for gender, race and ethnicity.
open repair versus branched endograft repair for treatment of residual chronic aortic arch dissection during follow-up after open type a acute ascending aorta replacement: results from an international multicenter study.

Conditions: Peri-operative Mortality

Summary: this study aims to evaluate peri-operative mortality and main post-operative complications (for example cardiovascular, respiratory and renal) in patients treated with frozen elephant trunk techinque.


Eligibility criteria:
inclusion criteria: * patients with post-dissection arch aneurysm with a maximal aortic diameter \>55mm or rapid growth (\>10mm/year) exclusion criteria: * emergency setting
efficacy of respiratory physiotherapy on severe icu-admitted covid-19 patients.

Conditions: COVID-19 Acute Respiratory Distress Syndrome

Summary: covid-19 is an infectious disease caused by sars-cov2 virus. covid-19 patients can develop a severe disease that can lead to hypoxic respiratory failure and acute respiratory distress syndrome (ards). severe patients can require access to intensive care unit (icu). early rehabilitation is known to be effective in critically ill patients and in ards. early rehabilitation is known to be effective in critically ill subjects. the role of physiotherapy in severe covid-19 patients is still unclear and few guidelines have been proposed so far. aim of this study is to assess efficacy of early rehabilitation for severe icu-admitted covid-19 patients as compared to a group that did not received physiotherapy treatment in icu.

covid-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), which emerged in china in december 2019 and in italy in february 2020. a large proportion of infected people have mild clinical manifestations, whereas \>10% develop a severe disease, which could evolve into acute hypoxemic respiratory failure (ahrf) and acute respiratory distress syndrome (ards) requiring intensive care unit (icu) admission. a high proportion of icu patients need invasive mechanical ventilation (imv) and about 50% of the icu-admitted patients die. the median age of icu covid-19 patients was \<65 years and the mortality in patients aged \<63 years ranges from 15 to 20%. early rehabilitation is safe and effective in critically ill patients and, in patients with ards, it helps to reduce the functional impairment due to the prolonged stay in icu. preliminary data suggest the implementation of early and active mobilization programs, as well as airway clearance, for patients with severe forms of covid-19. to date, the role of respiratory physiotherapy in severe covid-19 patients is still unclear. aim of this study is to assess efficacy of early rehabilitation for severe icu-admitted covid-19 patients as compared to a group that did not recevied physiotherapy treatment in icu. physiotherapy efficacy is evaluated in terms of ventilator free days (vfd) during the first 30 days after neuromuscular blockade stop. moreover, duration of icu stay and patient functional status at icu discharge will be evaluated.

Eligibility criteria:
inclusion criteria: * having laboratory confirmed covid-19 pneumonia * developed hypoxemic acute respiratory failure (harf) requiring access to icu * treated by physiotherapists during the icu stay * stopped the neuromuscular blokade treatment exclusion criteria: * previuos cognitive deficit (mini menatal state examination \<20)
the role of stem cells on immune cells in the development of cardiovascular diseases

Conditions: Atherosclerosis; Cardiovascular Diseases

Summary: an observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. to investigate whether long-term activation of the innate immune system, named 'trained innate immunity', occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with the proinflammatory phenotype of monocytes.


Eligibility criteria:
inclusion criteria: * age ≥18 and ≤75 years * with or without significant coronary artery disease on ccta * written informed consent exclusion criteria: * chronic infections * diabetes mellitus * medical history of any disease associated with immune deficiency * clinically significant infections within 3 months prior to study entry * recent hospital admission or surgery with general anaesthesia * known chronic kidney or liver disease * previous vaccination within 3 months prior to study entry * inability to personally provide written informed consent * inability to undergo pet-ct scanning * chronic use of anti-inflammatory drugs such as nsaids * history of haematological malignant disease * documented bleeding diathesis or thrombocytopenia * pregnancy

Keywords: hematopoietic stem cells
non-invasive optical detection of iron deficiency

Conditions: Anemia, Iron-Deficiency

Summary: this study aims to evaluate a prototype device detecting zinc protoporphyrin-ix fluorescence non-invasively from the intact oral mucosa. zinc protoporphyrin-ix is an established indicator of iron deficiency. the prototype device is used to measure the erythrocyte zinc protoporphyrin-ix/heme ratio for women after delivery, a study group chosen because of an elevated risk of iron deficiency. the results from the non-invasive measurements are compared to reference measurements of the erythrocyte zinc protoporphyrin-ix/heme ratio from residual blood samples from the same patients and to other indicators of iron status, including hemoglobin, ferritin, serum iron, transferrin, transferrin saturation and soluble transferrin receptor. funding source - nestec ltd.

this trial is a proof-of-concept study using a prototype fiber optic fluorometer to acquire autofluorescence spectra from women after delivery and determine the erythrocyte zinc protoporphyrin-ix fluorescence intensity from these spectra. the non-invasively determined fluorescence spectra are evaluated to provide a quantitative measure of the erythrocyte zinc protoporphyrin-ix/heme concentration ratio. these values are primarily compared to an erythrocyte zinc protoporphyrin-ix determined by hplc from residual blood samples from the same subjects and secondarily to erythrocyte zinc protoporphyrin-ix/heme ratios determined using a commercial hematofluorometer (aviv, model 206d) and other indicators of iron status, including hemoglobin, ferritin, serum iron, transferrin, transferrin saturation and soluble transferrin receptor this study could help to establish the non-invasive fluorescence measurement of zinc protoporphyrin-ix as a rapid, easy to use means for point-of-care screening for iron deficiency in resource-limited settings lacking laboratory infrastructure.

Eligibility criteria:
inclusion criteria: * women after delivery of term infants * pregnancy and delivery without study-relevant complications * hb value pre-partum greater or equal 12 g/dl or less or equal 11 g/dl * regular blood withdrawal before and after delivery for clinical indications * informed consent to participation in the study * age 18 or older exclusion criteria: * patients who are not legally competent * transfusion of blood products in the course of delivery * thalassemia and sickle cell anemia * any acute or chronic infectious or inflammatory disease * insufficient amount of residual blood in the clinically indicated post partum sample

Keywords: post-partum women
tai chi exercise and receptive music therapy for the elderly

Conditions: Elderly; Exercise; Therapy

Summary: frailty has become a major public health issue with the global aging population. in general, severe physical impairments and accompanying frailty in older adults are associated with adverse clinical outcomes. in addition to physical disorders, psychosocial disorders are also important in the formation of frailty. depression is one of the most common psychosocial disorders among older adults, with prevalence ranging from 6.5% to 25.3%. frail people may develop depression, and depressive symptoms negatively affect the physical functioning of the body, contributing to the development of frailty. this interrelationship between depression and frailty can lead to a vicious cycle with detrimental consequences for older adults. it is reported in the literature that elderly individuals experience low levels of well-being as well as depression. spiritual well-being means that the individual is aware of his or her own abilities, feels at peace, is not affected by the stresses that may exist in his or her life, and is not in a state of spiritual turmoil. poor mental health in the elderly increases fragility. this explains that frailty in elderly individuals affects all physical, social and psychological health components, and seriously negatively affects the quality of life and the formation and management of diseases. most of the research literature on frailty has focused on physical health. but mental health, which includes positive aspects such as cognition, sleep, social interactions and well-being, is just as important as that related to physical illness and disability. there is a serious need for similar research focusing on psychosocial interventions to prevent and manage frailty. studies are needed to show that promoting components such as resilience, social participation, and emotional regulation reduces stress levels in older adults, positively impacts mental health, increases healthy behaviors, and improves lifestyle, thereby reducing the risk of frailty. when the literature is evaluated, scientific studies in which music therapy and physical activity are applied have shown that these methods have positive effects on conditions that negatively affect mental health such as anxiety, stress and depression. there are no studies in the literature that discuss relaxing exercise and music therapy together for frailty in the elderly.

the aim of this study is to determine the effect of relaxing exercise and music therapy on the level of fragility and mental health in the elderly, who are considered to be a risk group in terms of public health.

Eligibility criteria:
inclusion criteria: * being 65 years or older * not having any obstacle to exercise * he has no problems with his hearing exclusion criteria: * not volunteering to participate in the study

Keywords: tai chi exercise receptive music therapy elderly vulnerability depression
study of the safety and tolerability of axa1957 in adolescent subjects with non-alcoholic fatty liver disease (nafld)

Conditions: NAFLD

Summary: this is a randomized, single blind study to determine whether axa1957, a novel composition of amino acids, is safe and well tolerated. subjects will be adolescents with non-alcoholic fatty liver disease (nafld), and it will also examine liver biology using blood tests and magnetic resonance imaging (mri).


Eligibility criteria:
key inclusion criteria: * willing to participate in the study and provide written informed consent. * male and female adolescent subjects aged 12 to 17 years * subjects must not have participated in any diet/lifestyle intervention or observational studies, or engaged in any body weight altering regimens that resulted in body weight fluctuations (i.e. body weight loss or gain by 5%) in the preceding 30 days prior to screening. * non alcoholic fatty liver disease * diabetes or prediabetes * a screening mri consistent with liver inflammation and fibrosis key exclusion criteria: * current or history of significant alcohol consumption * history or presence of liver disease (other than nafld/nash) * history or presence of cirrhosis and/or history or presence of hepatic decompensation * any diabetes other than type 2 * other poorly controlled medical condition (for example, uncontrolled hypertension with a systolic blood pressure \> 100 mmhg) * known sensitivity and/or history of clinically significant food intolerance/allergies to proteins (including whey, soy, casein, amino acids, etc.), * unable or unwilling to adhere to contraception requirements * any contraindications to a mri scan * any other condition that, in the opinion of the investigator, renders the subject at risk for compliance, compromises the well-being of the subject, or hinders study completion