Kornimate/medical-research-clean huggingface dataset:
rituximab and chemotherapy followed by ibritumomab tiuxetan as treatment for low grade follicular non-hodgkin's lymphoma

Conditions: Non-Hodgkins Lymphoma

Summary: in this trial, we will evaluate the feasibility, toxicity, and effectiveness ibritumomab tiuxetan, when incorporated into combination first-line treatment for follicular lymphoma. addition of the ibritumomab tiuxetan to our previously evaluated, well tolerated combination of rituximab and short course chemotherapy will allow the use of additional active agent with a unique mechanism of cytotoxicity. in addition, "debulking" of lymphoma prior to 90y zevalin administration may minimize the myelotoxicity of this agent.

upon determination of eligibility, patients will be receive: * rituxan + chop or cvp + ibritumomab tiuxetan patients who are considered medical candidates for doxorubicin should receive chop chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone). patients who are not considered medical candidates for doxorubicin should receive cvp chemotherapy (cyclophosphamide, vincristine, and prednisone)

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * histologic documentation of follicular center, b-cell lymphoma * early stage lymphoma (stages i or ii) relapsed after radiation therapy alone * no previous chemotherapy or monoclonal antibody therapy * measurable or evaluable disease * able to perform activities of daily living with minimal assistance * age \> 18 years * adequate bone marrow ,liver and kidney function * must be accessible for treatment and follow-up. * bone marrow examination initial staging and accurate restaging * all patients must give written informed consent prior to study entry. exclusion criteria: you cannot participate in this study if any of the following apply to you: * small lymphocytic (cll type) lymphomas and cll * impaired bone marrow reserve * female pregnant or lactating * serious active infection at the time of treatment * any other serious underlying condition * central nervous system involvement (brain or meningeal) * hiv or aids-related lymphoma * received prior external beam radiation therapy to \> 25% of active bone marrow * pleural effusion * received prior murine antibodies or proteins * history of other neoplasms within five years of diagnosis please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
type 2 continuous glucose monitoring academy

Conditions: Type 2 Diabetes

Summary: the goal of this clinical trial is to evaluate the impact of continuous glucose monitoring academy education curriculum versus standard care on glycemic outcomes for youth with type 2 diabetes (t2d): * the first aim is to determine how feasible it is to adapt the continuous glucose monitoring academy curriculum to teach youth with t2d glucose management strategies. * the second aim is to evaluate the effects of the continuous glucose monitoring academy metrics. * the third aim is to explore the relationships between these metrics with diabetes distress, diabetes family responsibilities, and process metrics. participants will join for a total of four weeks of education, followed by a six-month clinical review. they will have access to an online workbook and videos, and will participate in virtual sessions with a diabetes educator who will cover glucose management strategies in-depth. participants will wear their preferred continuous glucose monitoring system (dexcom or freestyle libre) provided via insurance and inserted at the baseline visit.


Eligibility criteria:
inclusion criteria: 1. current age of 13-24 years; 2. t2d diagnosis; 3. able to speak, read, and write english or spanish exclusion criteria: a. known history of medical adhesive allergies;

Keywords: continuous glucose monitoring glycemic control diabetes education type 2 diabetes
the effect of deep neuromuscular block on the perioperative stress response reduction and postoperative recovery enhancement in robot-assisted stomach cancer surgery

Conditions: Stomach Cancer

Summary: stress reactions caused by surgical stimuli can cause sympathetic nervous system activation and increased stress hormones, such as catecholamines, inflammatory cytokines, and pituitary hormones, and insulin resistance. in addition, increased catecholamine levels may exacerbate postoperative outcomes, especially delayed wound recovery, increased cardiovascular and respiratory complications, and immunosuppression. in particular, it is important to reduce the stress response for cancer patients during surgery because they are already immunocompromised status and more vulnerable to perioperative stressful situation. however, there are insufficient results on the benefits of deep neuromuscular block in these patients, although some have reported a reduction of postoperative pain and fewer complications in the deep neuromuscular block compared with moderate neuromuscular block. therefore, the investigators aim to investigate the difference in the stress response of patients who received conventional moderate neuromuscular block or deep neuromuscular block in robot-assisted gastric cancer surgery.


Eligibility criteria:
inclusion criteria: * 1. asa ⅰ - ⅱ patients between 20 and 65 years undergoing robot-assisted gastric cancer surgery exclusion criteria: * 1. patients with neuromuscular disease * 2. hypertensive patients with β-blockers * 3. diabetic patients receiving insulin therapy * 4. patients with severe heart (ef \ 100) * 5. patients with obesity (bmi ≥30) * 6. do not understand korean language * 7. for vulnerable subjects who are unable to obtain consent

Keywords: deep neuromuscular block robot-assisted surgery stress response stomach cancer
multiple dose-parallel-group study of ama0076 in patients with primary open-angle glaucoma or ocular hypertension

Conditions: Glaucoma; Ocular Hypertension; Eye Disease

Summary: the objective of this parallel group study is to evaluate the safety, tolerability and efficacy of ama0076 in reduction of intraocular pressure in subjects with primary open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * adults 30-85 years of age. * diagnosis of either poag or oht in both eyes. * not receiving medication for iop, or able to stop such medication for a washout period and the duration of the study without significant risk of adverse consequences related to glaucomatous disease. * elevated iop (≥ 24 and ≤ 33 mm hg at 8 am and ≥ 21 and ≤ 33 mm hg at 10 am on screening two visit and baseline visit in one or both eyes off treatment \[after a washout phase in those subjects who were receiving ocular hypotensive therapy\]). exclusion criteria: ophthalmic exclusion criteria: * uncontrolled intraocular hypertension defined as \> 33 mm hg in either eye at either of the screening/baseline visits (after a washout phase in those subjects who were currently receiving ocular hypotensive therapy). * receiving more than one medication for iop in either eye at time of screening. * abnormal central corneal thickness. * bcva worse than 20/200 (logmar 1.0) in either eye * significant visual field loss. * acute angle-closure glaucoma or appositional or very narrow anterior chamber angle in either eye.
collection of patient-reported symptoms and performance status via the internet

Conditions: Prostate Cancer; Breast Cancer; Lung Cancer; Colorectal Cancer; Leukemia; Multiple Myeloma

Summary: this pilot clinical trial studies how well using the internet to collect symptoms and the ability to carry out daily activities works in patients with enrolled on cancer and leukemia group b (calgb) studies. a study that evaluates a patient's ability to use a clinic waiting room computer to report their symptoms and their ability to carry out daily activities may help doctors understand a patient's use of a computer to report symptoms.

this study enrolled participants who were diagnosed with breast cancer, lung cancer, colorectal cancer, leukemia and multiple myeloma and prostate cancer. primary objectives: i. to assess the feasibility of collecting symptom data directly from patients at clinic visits via waiting-area computers. ii. to preliminarily assess the level of agreement between patient and clinician common terminology criteria for adverse events (ctcae) symptom severity scoring, and to measure whether their scores converge when clinicians are exposed to patient self-reports. outline: patients are registered into the symptom tracking and reporting (star) database, obtain a password, undergo star training, and complete a patient-star questionnaire after seeing their clinician (baseline self-report) on day 1 of course 2\* of chemotherapy. patients are reminded to complete online star questionnaire before seeing their clinician on day 1 of courses 3, 4, 5, and 6\* of chemotherapy. clinicians review these patient reports before creating their own assessment. patients also complete a patient feedback survey on day 1 of course 4\* of chemotherapy. clinicians complete feedback survey at study completion.

Eligibility criteria:
disease characteristics: * enrolled on clinical trial calgb-90401, calgb-30607, calgb-30704, calgb-40601, calgb-40603, calgb-40502, calgb-40503, calgb-70604, or calgb-80405 patient characteristics: * able to read and comprehend english language text * able to see a computer screen (i.e., no visual impairments) or be accompanied at visits by someone who can read the screen for the patient prior concurrent therapy: * see disease characteristics

Keywords: adenocarcinoma of the prostate recurrent prostate cancer stage iv prostate cancer
intrathecal morphine for robotic-assisted laparoscopic hysterectomy.

Conditions: Opioid-Related Disorders

Summary: is there any difference in the intensity of postoperative pain, nausea, urinary retention and legth of hospital stay in patients undergoing robotic assisted laparoscopic surgery if they receive intrathecal morphine or peroral and intravenous opiates during the surgery and is there a significant difference in the need of opiates after the surgery.


Eligibility criteria:
inclusion criteria: \* patients accepted for robotic-assisted laparoscopic surgery exclusion criteria: * coagulopathy, * prior spine surgery, * chronic pain problems, * drug abuse, * pregnancy * \< 18 years
24-hour intraocular pressure (iop) control with travoprost/timolol fixed combination

Conditions: Primary Open Angle Glaucoma; Exfoliation Syndrome

Summary: the purpose of this study is to compare the short-term (8 week) mean 24-hour intraocular pressure control and safety of travtim fixed combination given once in the evening with placebo once in the morning versus travtim given once in the morning with placebo once in the evening in patients with open-angle glaucoma.


Eligibility criteria:
inclusion criteria: * poag * exfoliation syndrome exclusion criteria: * advanced glaucoma
mri to characterize and predict cf liver disease in push cohort

Conditions: Cystic Fibrosis Liver Disease; Pancreatic Insufficiency

Summary: specific aim 1. determine if valid results of non-sedated mri based assessments of liver stiffness and lipid content can be obtained in more than 90% of children and young adults with cystic fibrosis. specific aim 2. determine hepatic lipid content using the hepafat sequence and liver stiffness using mre. investigators will compare the results obtained by mri with push study grayscale ultrasounds in cf patients with normal, heterogeneous, homogeneous or nodular (cirrhotic) pattern on ultrasound. specific aim 3. creation of an imaging core lab to centralize evaluation of mr imaging data, allow for remote image upload, electronic data storage, and remote image viewing/interpretation. this infrastructure will be utilized to standardize image post processing. specific aim 4. using the longitudinal push study, determine if mri based imaging improves discrimination of subjects at risk for progression to advanced cf liver disease (development of cirrhosis) compared to using us imaging alone

this proposal will be a cross sectional study of the current well-characterized push cohort. patients will receive an mri at the time of their scheduled push ultrasound. ideally, the mri will be performed the same day or a similar time point near liver ultrasound (+/-90 days, but investigators will allow a larger window due to the slow progression of fibrosis). blinded radiology review of imaging sequences will be performed by a local study radiologist with central review performed by the imaging core. analysis by the imaging core will include calculation of the liver stiffness, liver and spleen volume, and hepatic and lipid content for all mri studies.

Eligibility criteria:
inclusion criteria: 1. currently enrolled in longitudinal follow up in push study at a site with mr elastography. exclusion criteria: 1. age under 6 years (all current patients at time of opening of this study will be greater than 6 years of age). 2. internal appliance or hardware that is not compatible with mr. 3. inability to obtain mri within 6 months of us. 4. inability to cooperate with mri.

Keywords: cystic fibrosis liver disease pancreatic insufficiency
patient preferences in making treatment decisions in patients with stage i-iva oropharyngeal cancer

Conditions: Stage I Squamous Cell Carcinoma of the Oropharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Tongue Cancer

Summary: this pilot research trial studies patient preferences in making treatment decisions in patients with stage i-iva oropharyngeal cancer. questionnaires that measure patient priorities before and after treatment may improve the ability to plan for better quality of life in patients with oropharyngeal cancer.

primary objectives: i. determine the stability of head and neck priorities scale (hnps) ranking between pre- and post-treatment assessments. secondary objectives: i. use patient-interviews to refine and modify the hnps for use in a larger scale trial. ii. pilot the head and neck patient outcomes survey (hnpos) as a potential tool to identify priorities most important to quality-of-life outcomes. iii. use the functional assessment of cancer therapy - head and neck (fact-h\&n) and eurolqol-5d to determine the validity of the hnpos. outline: patients participate in a 45-minute interview comprising assessment of priorities and quality of life at baseline, 1, 6, and 12 months.

Eligibility criteria:
inclusion criteria: * treatment naïve american joint committee on cancer (ajcc) stage i-iva squamous cell carcinoma of the head and neck with no definitive evidence of metastatic disease * sufficient vision, writing, and communication ability to complete the interviews and assessment tool * signed informed consent exclusion criteria: * patients who are enrolled in other head and neck cancer treatment protocols are permitted to participate in this study if a) the other protocol permits this and b) the other protocol does not utilize the hnps * patients who have previously undergone cancer treatment or are presently undergoing additional cancer treatments * patients who have already undergone unsuccessful curative-intent surgery on their head and neck cancer * patients, who have had a major surgery (defined as requiring general anesthesia but not including tonsillectomy, neck dissection, or panendoscopy \[triple endoscopy or examination under general anesthesia\]), or significant traumatic injury within 4 weeks of the study; patients who have not recovered from the side effects of any of the above surgeries * patients unwilling to or unable to comply with the protocol * patients unable to communicate with the interviewer
olfactory biopsies

Conditions: Alzheimer Disease; Smell Loss; Smell Dysfunction

Summary: this research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. the olfactory lining is involved in the sense of smell. the purpose of this study is to collect tissue from the nasal cavity.

the purpose of this study is to analyze cell populations active in human olfactory tissue in health and disease. this is a prospective study. healthy participants or participants with known disease processes that may impact olfaction, such as alzheimer's, inflammatory conditions, aging, or post-viral smell loss, will be included. olfaction will be measured using standard psychophysical testing. biopsies of the olfactory lining in the nasal cavity may be obtained in the otolaryngology clinic or the operating room, if the patient is having an unrelated endoscopic nasal surgery, and may be obtained using a punch technique or a cytology brush. before biopsies, some patients may be asked to sniff an odor substance (such as lavender, mint, citrus, or cloves) briefly, to stimulate olfactory cells. biopsies will be processed for assays in the pi's lab, including histology, primary culture assays, flow cytometry assays, or transcriptomic profiling.

Eligibility criteria:
group 1: alzheimer's study inclusion criteria: * between the ages of 18 and 80 * pre-clinical ad (this cohort consists of subjects who have normal cognitive testing and function, but have positive ad biomarkers); * symptomatic ad (a confirmed diagnosis of alzheimer's or dementia who are capable of understanding and signing the consent document) exclusion criteria: * advanced alzheimer's/dementia * self-reported or known allergy to afrin or tetracain hcl (or related class of drugs) * active rhinosinusitis symptoms * other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps) * parkinson's disease * unable or willing to complete the nasal endoscopy procedure. * unable to read or speak english * unable to provide legally effective consent group 2: act-seq study or non-ad controls inclusion criteria: * age 18 years or older * patients being seen for rhinology or olfactory disorders * patients having unrelated endoscopic nasal surgery exclusion criteria: * self-reported or known allergy to afrin or tetracain hcl (or related class of drugs) * unable or willing to complete the nasal endoscopy procedure * unable to read or speak english * unable to provide legally effective consent

Keywords: act-seq nasal biopsy rna-seq
effects of caloric restriction and exercise on body weight, immune function, and intestinal flora

Conditions: Cardiometabolic Risk; Weight Loss; Immune System; Intestinal Microbiome

Summary: the purpose of this study is to estimate the effects of caloric restriction and exercise on body weight, cardiovascular metabolic markers, immune function, and intestinal flora among college students, as well as the underlying mechanisms.

in recent decades, carbohydrate-centered food pattern has brought worrying negative effects on human health, including increasing incidence of overweight, obesity, and cardiovascular diseases. animal experiments based on rhesus monkey showed that caloric restriction could prolong their healthy life years, while reports from population-based studies are quite inconclusive. there are some studies reporting that caloric restriction did reduce the risk of cardiovascular disease in those with obesity, while some other cohort studies found that not eating breakfast might increase the risk of coronary heart disease, diabetes and other related diseases. in addition, a number of studies claimed that continuous caloric restriction is associated with the depletion of peripheral immune cells, immune suppression and reduced bone mineral density. in spite of those inconclusive results, on the whole, fasting and caloric restriction in some way do improve the conditions of metabolism, overweight and obesity. previous studies mostly focused on middle-aged and elderly people, while recent studies in mice show that energy limitation in elderly people could not stop the aging process genetically or metabolically. therefore, this study aims to estimate the effects of caloric restriction and exercise on body weight, cardiovascular metabolic markers, immune function, and intestinal flora among college students, as well as the underlying mechanisms. a pilot study containing around 40 participants will be conducted firstly to assess the feasibility of this intervention plan.

Eligibility criteria:
inclusion criteria: 1. first and second year undergraduate students in sun yat-sen university. 2. bmi≥22 kg/m2. 3. having the time and volunteering to receive the interventions. exclusion criteria: 1. currently engaged in other weight-lossing studies. 2. with secondary obesity induced by medicine or other diseases. 3. with high blood pressure, diabetes or other cadiovascular diseases. 4. contraindication to exercise.

Keywords: caloric restriction exercise young adult