Kornimate/medical-research-clean huggingface dataset:
acute effect of transcutaneous electrical nerve stimulation in heart failure

Conditions: Improvement of Cardiovascular Autonomic Control; Reduction of Levels of Catecholamines

Summary: the purpose of this study is to determine acute effect the transctutaneous electrical nerve stimulation in sympathetic and parassympathetic system in individuals with heart failure.

heart failure (hf) is the inability of the heart to maintain adequate levels of blood supply to tissues. in recent years there has been an increased prevalence of heart failure (hf), in brazil there are about two million people diagnosed with hf and 240,000 new cases per year. thus, the ic constitutes the most serious problem now and in the fields of cardiology and public health. sympathetic activity is increased and correlates with a worse prognosis and survival in these patients. currently, the pharmacological blockade of the sympathetic system by chronic use of beta-blockers are commonly used to treat hyperactivity, but these interventions have side effects. the transcutaneous electrical nerve stimulation (tens) has been used successfully to control pain in different clinical conditions and may be a noninvasive strategy to reduce drug and not the severity of increased sympathetic.

Eligibility criteria:
inclusion criteria: * possess stable heart failure grade ii or iii according to nyha; * ejection fraction \<40% determined by echocardiography; * having no change in drug therapy one month before being included in the study; * there have been myocardial infarction (ami) three months before study entry; exclusion criteria: * patients with grade iv heart failure according to nyha; * acute respiratory; * unstable angina; * ventricular arrhythmia, unstable until three months before the start of the study; * pacemaker; * active smoking; * diabetes mellitus; * and fever or infectious disease.

Keywords: transcutaneous electrical nerve stimulation sympathetic nervous system parasympathetic nervous system heart rate
reducing range of motion deficits post radial fracture

Conditions: Radius Fractures

Summary: this a randomized controlled study to test the hypothesis that patients who perform in-cast exercises will have superior range of motion immediately post-cast removal, without a concomitant increase in complication rate when compared with a control group who receives standard post cast care which does not include the intervention exercises.


Eligibility criteria:
inclusion criteria: * patient experienced distal radial fracture * patient is over 18 years of age * patient can follow instructions and comply with protocol * fracture is managed non-operatively exclusion criteria: * bilateral wrist fractures * previous fracture to the affected wrist * previous range of motion limitations to the affected wrist * involvement of other upper extremity structures (i.e. shoulder)

Keywords: fracture radius adult range of motion
oligo-fucoidan decrease lung radiation damage

Conditions: Radiation Toxicity

Summary: fucoidan is fda approved and in common use for treatment of angina. these studies will advance that work to human use. successful mitigation of lung radiation damage and heart toxicity will improve the quality of life in veterans and non-veterans who are treated for lung cancer by radiation, and may also improve cure rates of radiation therapy for lung cancer.

this project will test the effect of fucoidan to mitigate the lung damage that can occur as a side effect of radiation therapy for lung cancer. thousands of veterans develop lung cancer every year, and are treated by radiation therapy. studies of lung radiation injury in laboratory animals show that with fucoidan, investigators can significantly reduce the severity of lung fibrosis and heart toxicity.1,2 fucoidan is fda approved and in common use for treatment of angina. these studies will advance that work to human use. successful mitigation of lung radiation damage and heart toxicity will improve the quality of life in veterans and non-veterans who are treated for lung cancer by radiation, and may also improve cure rates of radiation therapy for lung cancer.

Eligibility criteria:
inclusion criteria: 1. ages eligible for study: 20-90 years old 2. men and women undergoing radiation therapy for lung cancer，no matter the radiation therapy is for curing or for palliating. 3. karnofsky performance status，kps \> 70 4. absolute neutrophils \> 1000/mm\^3 5. platelets \> 75,000/mm\^3 6. hematocrit \> 25%. 7. liver and kidney function tests will be within normal range 8. baseline blood pressure will be systolic \> 110 mmhg sitting exclusion criteria: 1. patients who get lung cancer but no need or without the willingness of radiation therapy 2. patients who are taking antihtn drugs 3. women of pregnant, lactating, childbearing potential, or with the intention of becoming pregnant 4. patients who are presently participating in another clinical study (except for follow-up surveys for study outcomes) 5. patients who are judged to be ineligible for study entry by the investigator or subinvestigator

Keywords: radiation pneumonitis fucoidan radiation induced cardiac toxicity
association of anemia with hospital costs in elective colorectal surgery

Conditions: Surgery; Surgical Blood Loss; Anemia; Colon Cancer; Economic Problems

Summary: the objective is to measure the adjusted association between preoperative anemia and total hospital costs. we hypothesize that patients with anemia before surgery will have higher hospitalization costs than people without anemia.

this study will examine the association between preoperative anemia (hematocrit less than 0.39; low blood counts) and hospital total costs from elective colorectal surgery. total costs will be defined as the combination of direct and indirect costs ascertained using standardized patient-level costing algorithms (i.e. the standard way that hospital measure their costs). adjustment will be made for factors that are likely to influence both the presence of anemia and costs of care.

Eligibility criteria:
inclusion criteria: * elective hospital admission * having colorectal surgery exclusion criteria: * not enrolled in national surgical quality improvement program data collection
ability of changes in end tidal carbon dioxide to assess the stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room

Conditions: Blood Volume Expansion

Summary: volume expansion is the cornerstone of perioperative hemodynamic optimization. the main objective of volume expansion is to increase and to maximize stroke volume. despite national and international recommendations, stroke volume monitoring is clearly not widely adopted. this is mostly due to the cost and the invasiveness of the devices allowing stroke volume monitoring. end tidal carbon dioxide is monitored in all patients undergoing general anaesthesia and is totally non-invasive. a strong relationship between stroke volume and end tidal carbon dioxide have been already demonstrated. the aim of the present study is to determine if change in end tidal carbon dioxide can assess the stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room

the main objective of volume expansion is to increase stroke volume. franck-starling curve is schematically divided into two portions: a vertical portion which mean that an increase in preload secondary to volume expansion will induce an increase in stroke volume; and a flat portion which mean that a same increase in preload will not induce an increase in stroke volume. perioperative optimization is based on stroke volume maximization using volume expansion. despite national and international recommendations, stroke volume monitoring is clearly not widely adopted. this is mostly due to the cost and the invasiveness of the devices allowing stroke volume monitoring. end tidal carbon dioxide is monitored in all patients undergoing general anaesthesia and is totally non-invasive. several studies evaluated the relationship between stroke volume and end tidal carbon dioxide and other studies evaluated the ability of changes in end tidal carbon dioxide to assess changes in stroke volume induced by volume expansion with discordant results. these studies included small sample size and were heterogeneous (intensive care unit and nor operating room, volume expansion or passive leg raising, crystalloid or colloid, 500ml and not 250 ml ....). nowadays, it is not clear if changes in end tidal carbon dioxide can be considered as a surrogate of changes in stroke volume during a volume expansion in operating room patients. thus, the aim of the present study is to determine if change in end tidal carbon dioxide can assess the stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room. the follow up will be restricted to the duration of volume expansion. the last data will be collected just after the end of volume expansion.

Eligibility criteria:
inclusion criteria: * patient older than 18 years * scheduled for neurosurgery in prone position * equipped from an arterial catheter and stroke volume monitoring exclusion criteria: patient with cardiac dysfunction and/or lung disease

Keywords: blood volume expansion fluid responsiveness stroke volume perioperative optimization
biomarkers in samples of bone marrow from patients with acute myeloid leukemia

Conditions: Leukemia

Summary: rationale: studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is looking at bone marrow samples from patients with acute myeloid leukemia.

objectives: * to successfully transplant human acute myeloid leukemia (aml) cells into immunocompromised mice for the purpose of expansion of the cells. * to harvest the cells and use chromatin immunoprecipitation (chip) methods to identify the locations of the protein complexes on the genome. * to study the interactions of the super elongation complex (sec) and dot1 complex (dotcom) complexes in human leukemia samples. * to compare the genomic targets of the complexes formed by mll-enl chimeras to non-mll-rearranged leukemia samples to normal controls. outline: cryopreserved cells are implanted into nod scid gamma mice, expanded, harvested, and studied by chromatin immunoprecipitation (chip) methods (using antibodies to enl, af9, and af10). results are then analyzed by pcr, dna sequencing, and/or microarray analysis.

Eligibility criteria:
disease characteristics: * diagnosis of acute myeloid leukemia (aml) * cryopreserved mixed-lineage leukemia (mll) enl aml rearrangement cells, normal karyotype and non-mll rearrangement aml cells, and non-leukemic bone marrow samples from the cog tissue bank * 3 specimens of each type patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: adult acute myeloid leukemia with 11q23 (mll) abnormalities childhood acute myeloid leukemia/other myeloid malignancies
the application of the new magnetic resonance ute technique in thoracic lesions

Conditions: Lung Diseases

Summary: quantitative characteristic values of lung lesions were obtained by ute technique, so as to make qualitative diagnosis of benign and malignant lesions. and to explore the clinical feasibility of ct-like technology - high resolution zte technology in the diagnosis of pulmonary diseases.

ultrashort echo time (ute) sequence can obtain data from t2\* for lung imaging before t2\* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional mri cannot clearly display short t2 tissue imaging, and can provide more supplementary information for lung ct scan. there has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. the 3d ute sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung mr images, and has successfully obtained submillimeter high-resolution images. the purpose of this study was to explore the value of mri ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of ct-like technology - high resolution zte technology in the lung.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years old; 2. there are lung lesions, and the solid component is ≥6mm; 3. chest ct plain scan or /+ enhanced examination within 4 weeks. exclusion criteria: 1. there are metal implants in the corresponding parts of the chest; 2. mri contrast agent allergy; 3. claustrophobia; 4. pregnant women; 5. high fever; 6. respiratory failure; 7. lung lesion biopsy within 4 weeks prior to examination.

Keywords: lung mass, ute, zte, nodule, mri
minocycline treatment in retinitis pigmentosa

Conditions: Retinitis Pigmentosa; Inherited Retinal Dystrophy; Retina Disorder

Summary: the aim of this study is to evaluate the efficacy and safety of oral minocycline (100mg/d), administered for 6 months, for the treatment of patients with retinitis pigments(rp).

retinitis pigmentosa (rp)is a sort of inherited blinding disorders and no effective or safe treatment are widely applied for it. the worldwide prevalence of rp is estimated to be 1/5000. rp is characterized by degeneration of peripheral rod photoreceptor(pr) and associated retinal pigment epithelium(rpe) cells. nyctalopia and visual field constriction are common symptoms. cone degeneration and associated loss of central vision are typically followed later. minocycline, a secord-generation, semi-synthetic tetracycline antibiotic, is a highly lipophilic molecule and can easily pass through the blood-brain barrier. several animal experiments and clinical trials have reported that minocycline exert anti-apoptotic, anti-inflammatory and antioxidant effects in treating neurodegenerative diseases. we propose to test the effect and safety of oral minocycline for retinitis pigmentosa.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of retinitis pigmentosa: nyctalopia, visual field constriction and loss of central vision; degeneration of peripheral rod photoreceptor and retinal pigment epithelium cells. * age from 18 to 60 years old. * bcva \>20/100(0.2) at least in one eye. * full-field cone electroretinogram amplitude to 30-hz flashes \>0uv at least in one eye. * written informed consent is provided. exclusion criteria: * glucocortticoids or tetracycline were used within 3 months. * vitamin a, dha and other neurotrophic drugs were used within 3 months. * other ocular diseases or fundus diseases except cataract: glaucoma, diabetic retinopathy, retinal detachment. * tetracycline or minocycline allergy or intolerance. * renal or hepatic insufficiency. * history of thyroid neoplasm. * history of idiopathic intracranial hypertension. * pregnant or lactating females.

Keywords: retinitis pigmentosa minocycline erg inherited retinal dystrophy retinal degenerative disease
randomized controlled trial of long-term treatment effectiveness for meibomian gland dysfunction (mgd) and dry eye

Conditions: Meibomian Gland Dysfunction; Dry Eye

Summary: the study objective is to evaluate the long-term treatment effectiveness for adult patients with meibomian gland dysfunction (mgd) and evaporative dry eye by: 1) comparing the lipiflow® system to a standardized daily warm compress and eyelid hygiene control therapy over a duration of 3 months; and 2) evaluating the lipiflow® alone and in combination with other mgd and dry eye treatments over a duration of up to 12 months. this is a post-market, non-significant risk, prospective and multi-center clinical trial divided into two stages. the first stage from enrollment to 3 months is an open-label, randomized controlled design to compare the effectiveness of a single lipiflow® system treatment to a standardized daily warm compress and eyelid hygiene control therapy with crossover lipiflow® treatment of the control subjects at 3 months. the second stage, occurring between 3 and 12 months, is an observational design to evaluate the effectiveness of lipiflow® alone and in combination with other mgd and dry eye treatments over a duration of up to 12 months. subjects are entered into the following subgroups based on the subject's self-assessment of the adequacy of symptom relief and protocol-defined criteria for additional treatment. 1. one lipiflow® treatment: subjects who receive only one lipiflow® treatment. 2. two lipiflow® treatments: subjects who receive a second lipiflow® treatment. 3. combination treatment: subjects who receive one or two lipiflow® treatments followed by other mgd or dry eye treatment, as prescribed by the physician.


Eligibility criteria:
inclusion criteria: * at least 18 years old * tear film assessment that qualifies in both eyes * evidence of meibomian gland dysfunction and dry eye in both eyes * willingness to comply with study protocol exclusion criteria: * systemic disease condition or medication that causes dry eye * use of other treatments for mgd or dry eye * ocular surgery, trauma, herpes infection, punctal plug insertion or punctal occlusion within past 3 months * active eye infection * active eye inflammation or recurrent inflammation within past 3 months * moderate to severe allergic conjunctivitis * severe eyelid inflammation * eyelid abnormality that affects lid function * ocular surface abnormality that may compromise corneal integrity * pregnant or nursing women * participation in another ophthalmic clinical trial within past 30 days
factors impacting the prevalence of mdr bacteria

Conditions: Multi-antibiotic Resistance

Summary: 1. to determine the prevalence of multidrug resistance bacteria in patient with different infections 2. to evaluate patients' predictive risk factors of antimicrobial resistance 3. to assess the association between patients' factors and prevalence of mdr bacteria

antimicrobial resistance is one of the most critical public health issue in this century . who declared antimicrobial resistance as one of the top ten global health threats that impend the effective management and prevention of evolving infections . antimicrobial resistance nowadays poses a big challenge because of the emerging of resistance to the antibiotics that previously effective and development of multidrug resistance infections with subsequent increase in morbidity, mortality and financial loss . in spite of who health strategies that taken to face multidrug resistance problem, the burden of antimicrobial resistance in europe is compared with combined burden of influenza and hivs .while in usa the estimated antibiotics resistance infections is 2.8 millions and the related deaths exceeded 35,000 every year and expected to reach to ten million deaths with collective cost of 100 trillion usd annually in 2050 . numerous studies reported that self-medications, improper prescription, overuse of antibiotics, deficiency of antibiotics susceptibility test and limited knowledge and attitude of population towards antibiotics are the main factors that lead to antibiotics efficacy being reduced with long hospital stay. other studies stated that the predictive indicators of mdr tragedy are age, gender, comorbidities, previous hospital stay or antibiotic use . in low and middle income countries like iraq there is a difficulty in estimation the scope of antibiotics resistance problem and its evolving over time due to the lack of surveillance, besides alarmingly excessive antibiotics consumption added other challenges and urged us to aim this study .

Eligibility criteria:
inclusion criteria: * patients who were screened for mdr bacteria * patients who accepted to participate in the study exclusion criteria: * patients with no growth media * patients who cannot communicated
a trauma-informed intervention for positive youth development and teacher wellness in rural montana year 2

Conditions: Trauma and Stressor Related Disorders

Summary: compared to u.s. urban counterparts, rural residents face major barriers to using health care services. challenges include shortages of services, long distances to existing services, and stigma regarding mental illness in isolated communities. these difficulties hold true for montana, but especially for adolescents. the objective of a trauma-informed intervention for positive youth development and teacher wellness in rural montana is to improve stress-related mental and physical health outcomes for adolescents and educators in rural montana through school-based, trauma-informed yoga exercises. this project builds on investigators' previous research (including a two-year cairhe pilot study, 2019-21) to promote positive youth development by simultaneously intervening with students and teachers with a trauma-informed yoga intervention. geographic isolation and resulting lack of resources for many montanan schools indicates a need for novel, school-centered interventions to address the needs of rural adolescents; yoga can benefit youth and teacher wellbeing.

in year 2, investigators will expand the study to pilot test a remote delivery for students and teachers in rural schools through virtual delivery (in addition to an in-person high school student intervention at the school district of aim 1. primary outcomes for teachers will assess career satisfaction/self-efficacy; primary outcomes for students will assess depression/anxiety symptomology. effects on secondary mental/physical health outcomes will be drawn from survey results, cortisol levels, and heart rate variability measures (collected pre/post). investigators will then determine which intervention design was more effective with students (in-person vs. remote) between the two years of this feasibility study through an outcome evaluation. comparisons of mental and physical health outcomes will be examined by the research team using cohort data drawn from participants' physiological data and survey results. the short-term public health impact of this study is to improve the mental and physical health of rural montana youth and teachers through a novel, school-based intervention. if successful, this study's long-term public health impact will reduce rates of anxiety and depression and improve physical health in geographically isolated settings.

Eligibility criteria:
inclusion criteria: * any teacher currently employed by the livingston or gardiner school district who wishes to participate in the intervention (up to 45 participants) * any freshmen student enrolled in pre-selected pe classes at park high school in livingston montana * any pe student enrolled in pre-selected pe classes at gardiner high school in gardiner montana exclusion criteria: * any students that are not enrolled in pre-selected pe classes at park or gardiner high schools in southwest montana