Kornimate/medical-research-clean huggingface dataset:
evaluation of the use of a urin test strip to determine the spread of schistosoma infections in areas where schistosomiasis infections are low in kenya

Conditions: Schistosomiasis Mansoni; Circulating Cathodic Antigen Urine Based Dipstick

Summary: the purpose of this study is to evaluate the use of a urine test strip in diagnose schistosoma mansoni in areas of kenya where the rate of infections are low. the hypothesis is that the urine strip test is a superior tool to the conventional parasitological tools used to diagnose schistosomiasis mansoni infections in area where there is low transmission

the study will compare the use of the urine test strip with the conventional method used and with a "golden standard" methode, in an area of kenya where the infection transmission is low. furthermore will the urine test strip be evaluatied in its ability to monitor the intensity of infections in school children before and after they are been treated for the infections. a total of 1100 school children in the age between 10 and 18 years will be included in the study. children have to submitt a stool and a urine sample on three consecutive days. children who are found to be infected with the schistosomiasis parasite will be offered treatment.

Eligibility criteria:
inclusion criteria: * children in the age between 10 and 18 years exclusion criteria: * children younger then 10 years of age and children whos parent/guardians did not give informed consents for their participation in the study

Keywords: schistosomiasis schistosoma mansoni circulating cathodic antigen urine dipstick
laparoscopic surgery equivalent to open surgery in right colon cancer surgery?

Conditions: Colon Cancer

Summary: the primary goal of this study is to compare in the long-term costs of laparoscopic or open right colectomy in patients sustaining a colon cancer controling for the carcinologic equivalence of the two surgical strategies. the secondary goals to compare long-term mortality, morbidity as well as quality of life of the two groups.the present study is an prospective multicentric observational trial taking into account the usual surgical strategy of every centers

the aim of the present study is to compare in the long-term costs of laparoscopic and open right cancer colectomy as well as the mortality the morbidity and the quality of life of the operated patients. the number of patients need to get a 54% power is 300. the average number of patients/surgical center is approximately 27 in 14 surgical centers. the proposed undertaking of every patient is fully identical to that which is usually proposed by the surgical center in charge of the patient (i.d. 7 centers will perform laparoscopic procedures and 7 centers open procedure according to their usual practice). a complete information leaflet will be given to the patients during the first consultation which will correspond to the enrollment day. the preoperative, intraoperative and postoperative period will be in complete accordance with the usual care of the center. the baseline demographics and conditions as well as the perioperative items and the postoperative occurrences will be recorded through a prior designed e-questionnaire. the follow-up encompass 5 postoperative consultations:1 month, 6 ,12 ,18 and 24 months. on every consultation the patient will fill a very simple validated quality of life questionnaire (eortc,qlq.c30) an give back a weekly journal reporting the potentially arising medical and surgical events. globally the comparative analysis of the costs ,the mortality ,the morbidity, the quality of life ot the patients undergoing either a laparoscopic or a open right colectomy for cancer will be performed controling for the carcinologic equivalence of the two surgical strategies.

Eligibility criteria:
inclusion criteria: * age ≥18 years old \<= 80 years old * right colon cancer \< t4 without metastasis * \<t4 n0m0 exclusion criteria: * pregnant patient * t4 cancer * metastasis

Keywords: colon cancer surgery laparoscopy open surgery costs mortality morbidity quality of life
exercise intervention for patients with sarcopenia or frailty in long-term care institutions

Conditions: Sarcopenia

Summary: sarcopenia is a geriatric syndrome of decreased muscle volume with muscular function decline. there is more tendency for sarcopenic elderly to be frail, disabled, or have cardiovascular disease. compared to those who are not sarcopenic, they also had worse prognosis in response to treatment for definite diseases, and spend more medical cost. exercise appears to have an important role in management of sarcopenia. in the current study, the investigators provide an exercise program, including resistance/balance training for the elderly with sarcopenia or frailty in long-term care institution, and evaluate the effect.


Eligibility criteria:
inclusion criteria: 1. \>20-year-old 2. diagnosed with sarcopenia (by the definition from asia workgroup for sarcopenia, awgs) or frailty (the fried model, based on five functional criteria) exclusion criteria: 1. severe medical diseases or mental problems, which result in difficulty to follow exercise program. 2. inability to get down from bed for activity due to disease, such as neuropathy or orthopedic disease. 3. high risk group for exercise program, such as those with unstable fracture or nonunion fracture. 4. anyone who didn't want attend this study.
treatment of perioperative neurocognitive disorders with olfactory enrichment

Conditions: Perioperative Neurocognitive Disorder

Summary: perioperative neurocognitive disorder (pnd) is one of the most common postoperative complications among elderly patients. however, the mechanism and targeted intervention of pnd remains unclear. our previous clinical studies demonstrated the association between olfactory impairment and pnd. moreover, our translational studies showed that anesthesia/surgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia/surgery-induced cognitive impairment. however, there was no clinical investigation to determine whether olfactory enrichment can mitigate pnd in elderly patients. therefore, we propose determining whether olfactory enrichment can prevent and/or treat pnd in elderly patients.

the study will be a double-blinded, randomized controlled trial. participants (65 years old or older) undergoing scheduled orthopaedic surgery (≥2 hours, under general anesthesia) will be randomized to either olfactory enrichment group or sham group. participants in olfactory enrichment group will receive olfactory enrichment with a dispenser twice sessions per day on preoperative day 1-3 and postoperative day 1-3 (30 min per session, 4 odors for each session) while participants in sham group will be equipped with the same pattern except that water will be used in the dispenser. participants will be assessed twice daily by a research assistant blinded to allocation. the primary outcome will be the incidence of postoperative delirium measured by the confusion assessment method on postoperative days 1, 2 and 3. the secondary outcomes will be the severity of postoperative delirium, cognitive function, plasma tau-pt217 level, and olfactory function.

Eligibility criteria:
inclusion criteria: 1. age ≥65 years old. 2. having a scheduled surgery (≥2 hours, general anesthesia) (e.g., total hip replacement, toal knee replacement, open reduction and internal fixation of hip and lumbar spine). 3. being able to complete neuropsychological tests, 3d-cam and cam-s. 4. chinese mandarin as their native language. 5. edmonton frailty scale (efs) score ≥ 6. exclusion criteria: 1. having delirium, assessed by 3d-cam, before surgery. 2. having a brain tumour, stroke or mental disorders (eg, major depressive disorder or dementia). 3. participating in other clinical studies at the time of screening. 4. unwillingness to comply with the protocol or procedures.

Keywords: perioperative neurocognitive disorder odor enrichment
study of larotaxel in combination with weekly herceptin® in patients with her2 positive metastatic breast cancer

Conditions: Advanced Breast Cancer; Breast Cancer; Metastatic Breast Cancer

Summary: the purpose of this study is to evaluate the anti-tumor activity of the combination of experimental drug (larotaxel) when combined with herceptin® in patients with advanced breast cancer. anti-tumor activity will be determined by looking at changes in tumor size on ct or mri scans. additional goals of this study are to look at patient safety, to determine how long the study drugs (larotaxel and herceptin®) stay in the patient's body and what effects the study medications may have on each other, and to find out how long patients remain cancer free on this study treatment.


Eligibility criteria:
inclusion criteria: * diagnosis of breast cancer * evidence that cancer has spread beyond its original location or has come back and cannot be removed by surgery * no more than one prior treatment for advanced disease * her2 positive status * adequate liver and kidney function * no remaining severe harmful effects to prior treatments exclusion criteria: * certain heart condition * pregnant women * history of another cancer except some skin cancers and cervical cancer * taking other treatments for your cancer at the time you enter the trial

Keywords: herceptin taxane breast cancer
efficacy and safety of dapagliflozin in combination with metformin in type 2 diabetes patients

Conditions: Type 2 Diabetes

Summary: this study is being carried out to see if dapagliflozin as an addition to metformin is effective and safe in treating patients with type 2 diabetes when compared to glipizide (sulphonylurea) as an addition to metformin treatment.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * treated with oral anti-diabetic drug therapy therapy including metformin for at least 8 weeks prior to enrolment * hba1c \>6.5% and \</=10% exclusion criteria: * type 1 diabetes * insulin therapy within one year of enrolment * renal (kidney) failure or dysfunction

Keywords: dapagliflozin efficacy safety metformin type 2 diabetes
digital therapeutic for chronic pain feasibility study

Conditions: Chronic Pain

Summary: the investigators will conduct a 2-arm randomized control feasibility study to evaluate: 1) the feasibility of using the mobile app and an optional activity tracker, 2) the feasibility of conducting a 2-arm trial, and 3) estimate the effect size for planning for a larger efficacy trial based on our primary outcomes. the intervention arm will test a mobile app that aims to help people reduce pain interference who have chronic pain, as well as mental health issues with depression and anxiety. participants in the intervention arm will also have the option to sense health data with a tracker that integrates with the app, which will inform the feasibility of this feature.

this study will evaluate the existing 2morrow chronic pain self-management program, in the form of a mobile app, as a digital therapeutic for improving patients' pain self management and function who suffer from chronic pain. specifically, the investigators will conduct a 2-arm randomized control feasibility study to evaluate: 1) the feasibility of using the mobile app and an optional activity tracker, 2) the feasibility of conducting a 2-arm trial, and 3) estimate the effect size for planning for a larger efficacy trial based on our primary outcomes. the intervention arm will test a mobile app that aims to help people reduce pain interference who have chronic pain, as well as mental health issues with depression and anxiety. participants in the intervention arm will also have the option to sense health data with a tracker that integrates with the app, which will inform the feasibility of this feature.

Eligibility criteria:
inclusion criteria: * \>=18 years old * at least one icd pain related diagnosis noted in the electronic health record (ehr) * at least 2 visits in a primary care clinic with at least one in the last 12 months * willing to use a mobile app in english * t-score for the promis brief pain inventory of \>= 55 * access to a smartphone * willing to download and use a mobile app daily exclusion criteria: * current cancer related diagnosis (to exclude cancer related chronic pain) * plans for surgery in next 3 months * pregnant * currently receiving hospice care

Keywords: chronic pain primary care digital therapeutic mobile app pain function pain interference psychotherapy
functional electrical stimulation of peripheral muscles in heart failure with preserved left ventricular ejection fraction

Conditions: Heart Failure With Preserved Left Ventricular Ejection Fraction

Summary: the purpose of this study is to evaluate the effects of functional electrical stimulation of peripheral muscles on clinical and emotional status, endothelial function and left ventricular diastolic function in heart failure with preserved left ventricular ejection fraction.


Eligibility criteria:
inclusion criteria: (i) symptoms \[new york heart association (nyha) class ii or iii\] and signs typical of heart failure (ii) left ventricular (lv) ejection fraction (lvef) \>50% and lv end-diastolic volume index \<97 ml/m2 (iii) findings of left atrial (la) dilatation (la volume index \>40ml/m2), lv hypertrophy and/or lv diastolic dysfunction \[ie, mitral e/a ratio \ 2, mitral e/e' ratio \>15 or 8-15, (a pulmonary - a mitral) duration difference \>30 ms etc) (iv) no alterations in medical therapy during the previous 4 weeks (v) no myocardial infarction within 3 months prior to enrollment exclusion criteria: recent (≤4 weeks) heart failure decompensation * acute coronary syndrome * chronic inflammatory diseases and malignancies
advanced footwear technology in federated athletes

Conditions: Athlete Foot

Summary: background. athletics is one of the sports modalities with the greatest growth in the number of federative licenses in our country. in the last five years, the use of footwear with advanced footwear technology (aft) has become widespread in order to increase athletic performance. objective. to analyze the risk of injury in athletes using advanced footwear technology as well as the sporting, sociodemographic and anthropometric variables that influence this risk. method. ambispective cohort study. ninety-five athletes competing in events longer than 800 meters will be recruited. the primary variable will be the number of injuries, muscular and tendon, of lower limbs in the last 3 athletic seasons. secondary and modifying variables will be: age, sex, weekly training load with and without aft, weekly training frequency, completion of a complementary toning program and foot size. potential confounding variables will be body mass index, main training surface and commercial footwear models used. the analysis will calculate the risk of injury in these athletes and assess the influence of confounders and trend analysis on the primary variable, stratified by potential confounders. expected results. to calculate the risk of injury as a function of sport, sociodemographic and anthropometric variables. identify


Eligibility criteria:
inclusion criteria: * athletes competing in events longer than 800 meters; iii) athletes who have not undergone previous musculoskeletal surgery in the seasons under study. * federated in the federación de atletismo del principado de asturias (asturias athletics federation). * athletes who have not undergone previous musculoskeletal surgery in the seasons under study. * who were federated at least one year before the study period. exclusion criteria: * athletes who do not use aft devices. * athletes with a muscle or tendon injury at the time of the study.

Keywords: disease athletics advanced footwear technology risk secondary prevention physiotherapy
efficacy of preoperative nutritional support on postoperative outcome in gastric cancer patients at nutritional risk by nrs-2002

Conditions: Malnutrition; Gastric Cancer

Summary: evaluation of the impact of preoperative nutritional support on clinical outcomes in patients at nutritional risk. the primary endpoint was the complication rate and the second endpoint was the length of stay.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of gastric cancer surgery preoperative stage exclusion criteria: * neoadjuvent chemoradiation * pregnant * advanced stage

Keywords: malnutrition gastric cancer preoperative nutrition
changes in ectopic fat following surgically induced weight loss

Conditions: Obesity; Type 2 Diabetes

Summary: this study evaluates how ectopic fat (in the pancreas, heart, liver and skeletal muscle), visceral fat, and subcutaneous fat changes following surgically induced weight loss using gastric banding. the investigators also evaluate whether changes in pancreatic fat content correlate with improvement in beta-cell function.

we are looking for volunteers for this study,wich involves 7 visits over a period of 13 months, the first visit taking place about 2 weeks prior to the planned surgery. visit 1 - baseline, before starting your pre-operative diet visit 2 - just before the surgery visit 3 - around the time your first band inflation occurs visit 4 - 1 month after the band inflation visit 5 - 3 months after the first band inflation visit 6 - 6 months after the first band inflation visit 7 - 12 months after the first band inflation at each visit we do the following tests: 1. mrs to measure your fat in the liver, pancreas, heart, muscle (leg), subcutaneous fat and visceral fat. 2. frequently sampled intravenous glucose tolerance test - it is a 3.5 hrs test which determines the amount of insulin your body produces and how well your own insulin is being used by the body 3. body measurements (waist, hip circumference), cholesterol panel, liver function tests, hba1c (to monitor diabetes control), blood pressure, weight. we also do an oral glucose tolerance test to check for diabetes on 3 occasions: visit 1, visit 5 and at the end, visit 7.

Eligibility criteria:
inclusion criteria: * greater than 18 years old * fully understanding and willing to undergo study procedures * available for follow-up * understand and willing to sign informed consent * pharmacologic agents with the potential to change ectopic fat content (i.e. pioglitazone) are allowed if the patient has been on a stable dose for at least 3 months and plans to continue the same dose for the duration of the study exclusion criteria: * contraindication to mri (i.e. metallic implants, severe claustrophobia, weight above 320lb) * contraindication to phlebotomy (i.e. no accessible veins, hemoglobin \<10 mg/dl) * history of pancreatic disease other than diabetes * regular use of more than 2 alcoholic drinks per day * pregnancy * non-english speaking

Keywords: obesity type 2 diabetes gastric banding
biology and genetics of smouldering myeloma

Conditions: Smouldering Myeloma; MGUS; Multiple Myeloma

Summary: observational clinical trial recruiting smouldering myeloma patients (smm) or potential smm patients. study involves collecting blood and bone marrow samples to determine the features of the tumour genome and bm microenvironment, including immune dysfunction that are key drivers of progression from precursor conditions (mgus and smm) to mm.

mm is a cancer of plasma cells characterised by bone marrow infiltration by malignant plasma cells, kidney impairment, bone pain and elevated calcium levels1. there are approximately 5,500 new cases diagnosed annually in the uk, with a median survival of 5 years2. significantly, despite improvements in conventional treatment options, mm remains incurable; patients inevitably relapse and will eventually die from their disease.3 mm is always preceded by defined precursor conditions, termed mgus, and smm. however, only 7% of mgus patients and 50% of smm patients progress to mm over a 5-year period4. in the uk, current practice favours commencing treatment only when there is evidence of end organ damage as the overall benefit of initiating early therapy is uncertain. there is an increasing understanding that progression is determined by evolving changes in the tumour genome5 and changes in the immune microenvironment which support tumour growth, leading to progressively dysfunctional anti-tumour immunity. this project correlates changes in the tumour genome and immune microenvironment in individual patients with tumour progression and also aims to compare characteristics in patients with good and poor clinical outcomes with the objective of defining the drivers for disease progression. furthermore, we aim to explore the use of blood samples to monitor tumour dynamics and immune function. finally, we will also study the spatial distribution of immune cells and tumour cells in the bone marrow. clinical impact: a deeper understanding of the pathogenesis of mm will allow us to risk stratify patients with mgus and smm, and manage them accordingly as well as identifying subgroups of patients with mm who require different types of therapies, eg. more intensive multi-drug approaches for patients with adverse risk genetics.

Eligibility criteria:
inclusion criteria: * any individual with a confirmed or suspected diagnosis of mgus, smm, or mm. exclusion criteria: * patients under the age of 18 * patients with active symptomatic myeloma at diagnosis * patients with no evidence of mgus, smm or mm * patients with rapidly rising paraprotein or serum free light chains suggestive of progressive disease at time of diagnosis or inclusion into study
pain evaluation during follicle aspiration: comparison of two sedation protocols

Conditions: Pain

Summary: giving infiltration analgesia around the neck of the womb (= paracervical block, pcb) is frequently experienced as a painful procedure by women undergoing follicle aspiration. two sedation protocols, where in the one protocol a low dose of alfentanil hydrochloride is already administered before the pcb, will be compared with each other and pain relief measured using the 'visual analogue scale' and the 'short-form mcgill questionnaire'


Eligibility criteria:
inclusion criteria: * healthy women and female infertility patients * between 18 and 43 years of age exclusion criteria: * patients with a known allergy to alfentanil hydrochloride or comparable drugs (morphine, cocaine)

Keywords: sensation relief during surgery
beta cell function in women with turner syndrome

Conditions: Turner Syndrome

Summary: diabetes is more frequent in women with turner syndrome. the purpose of this study is to see, in what ways the glucose metabolism is different in this study population. the hypothesis is that women with turner syndrome have an impaired insulin production (beta cell function).


Eligibility criteria:
inclusion criteria: * turner syndrome exclusion criteria: * diagnosed diabetes * bmi\>30 * untreated cardiac or thyroid disease * cancer illness