Kornimate/medical-research-clean huggingface dataset:
comparing the effects of muscle energy technique versus myofascial mobilization in managing sub-acute low back pain

Conditions: Lordosis; Low Back Pain

Summary: institute for clinical systems improvement (icsi) defines sub-acute low back pain as low back pain lasting between 4 and 12 weeks. there is insufficient evidence regarding the comparative effect of muscle energy technique and myofascial mobilization in the management of sub-acute non-specific low back pain with the tightness of quadratus lumborum and erector spinae muscles

a randomized experimental controlled trial will be carried out to compare the effectiveness of muscle energy technique and myofascial mobilization in the management of sub-acute non-specific low back pain. a total of 60 male and female volunteers having subjects with sub-acute nonspecific low back pain will be recruited in this study. subjects will be assessed at baseline for pain and disability using visual analogue scale and ronald morris disability questionnaire (rmdq 0-24) respectively. after baseline assessment, all subjects will be allocated to two groups through computer-generated random sampling. group 1 will perform muscle energy technique combined with conventional exercise; group 2 will receive myofascial mobilization combined with conventional exercise. this study will be conducted at the physiotherapy department of sindh institute of physical medicine and rehabilitation (sipm\&r). data will be analyzed using spss 21 and ancova technique will be used in this study.

Eligibility criteria:
inclusion criteria: * sub-acute low back pain with the range of 7 to 12 weeks of unresolved symptoms. * positive test of tight erector spinae muscle and tight quadratus lumboram muscle exclusion criteria: * spinal malignancy * spinal fracture * spine foraminal stenosis * nerve root compression * radicular symptoms * sciatica * cord compression * paralysis * muscular dystrophy * myelopathy * seizure disorder * severe trauma * unexplained weight loss
an exploratory study of tocilizumab in patients with active rheumatoid arthritis (ra) and an inadequate response to current non-biologic dmards and/or anti-tnf therapy.

Conditions: Rheumatoid Arthritis

Summary: this open-label, single arm study will investigate the safety, tolerability and efficacy of tocilizumab monotherapy, or combination therapy with non-biologic disease modifying antirheumatic drugs (dmards), in patients with severe active ra. patients will receive tocilizumab 8mg/kg iv as a 60 minute infusion every 4 weeks for a total of 6 infusions. the anticipated time on study treatment is 3-12 months, and the target sample size is \>500 individuals.


Eligibility criteria:
inclusion criteria: * male and non-pregnant or nursing female patients \>=18 years of age; * body weight \<=150kg; * moderate to severe active ra (das28 \>=3.2) of \>=6 months duration; * on \>=1 non-biologic dmards at a stable dose for a period of \>= 8 weeks prior to start of treatment; * inadequate clinical response to a stable dose of non-biologic dmard or anti-tnf therapy; * if receiving oral corticosteroids, the dose must have been stable for at least 25 of 28 days prior to start of treatment. exclusion criteria: * major surgery (including joint surgery) within 8 weeks prior to screening or planned major surgery within 6 months following enrollment; * rheumatic autoimmune disease other than ra; * prior history of, or current inflammatory joint disease other than ra; * functional class iv as defined by the acr classification of functional status in ra.
neurally adjusted ventilatory assist and synchrony in patients with chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: nava used the electrical activity of the diaphragm (eadi) to initiate and deliver in proportion of an inspiratory assistance. during inspiration, eadi signal occurred earlier than airflow or pressure variations in the airway. the investigators hypothesized that nava improved patient-ventilator synchrony and reduced inspiratory workload as compared with pressure support ventilation delivered at two different cycling criteria (25 and 50 %).


Eligibility criteria:
inclusion criteria: * history of chronic obstructive pulmonary disease * admitted for acute respiratory failure requiring invasive mechanical ventilation * currently receiving pressure support ventilation exclusion criteria: * age \< 18 years * respiratory rate \> 35 bpm * severe hypoxemia with spo2 \ 50 % * heart rate \> 120 bpm * systolic arterial pressure \< 90 mmhg * contraindication to naso-gastric tube's insertion

Keywords: mechanical ventilation neurally adjusted ventilatory assist (nava) acute respiratory failure chronic obstructive pulmonary disease weaning invasive mechanical ventilation positive pressure support ventilation
breathe anew for lung cancer survivorship

Conditions: Lung Cancer

Summary: survivorship programs have become an integral component of modern cancer care programs. in canada, there has been tremendous success for survivorship programs for breast, prostate, and colorectal cancer, however lung cancer survivorship programs have not been widely developed. the complexity of the disease, high mortality, short survival times, high cost of surveillance, and patient habits have traditionally been barriers against the success of lung cancer survivorship programs. the investigator proposes a feasibility study to pilot a novel intervention titled breathe anew, which will aim to identify and overcome the barriers to the design and implementation of a lung cancer survivorship program. the investigator has assembled a multi-disciplinary team of experts and lung cancer survivors who will develop the breathe anew survivorship intervention. the intervention will be vetted using an integrated knowledge translation approach, which will involve members of the target population, primarily patients who previously underwent lung resection, to modify the intervention and ensure acceptability. after breathe anew has been designed, it will be tested in a pilot study of 50 patients to ensure its feasibility and determine its cost. the ultimate goal of this feasibility study is to lay the groundwork for a subsequent comparative trial to evaluate the impact of breathe anew on patient-important outcomes including health related quality and length of life and postoperative complications.


Eligibility criteria:
inclusion criteria: * age 18 years or older * all patients at st. joseph's healthcare hamilton who received lung resection for stage i, stage ii, or stage iiia non-small cell lung cancer are eligible to enroll. * owns a smart device exclusion criteria: * patients who received lung resection for stage iiib or iv non-small cell lung cancer * patients with affected mobility (walker, wheelchair) * patients who use oxygen at home
comparison of 6-fluoro-[18f]-l-dihydroxyphenylalanine (18f-dopa) positron emission tomography (pet) and multiparametric resonance magnetic imagery (rmi) in initial exploration of glial tumors

Conditions: Brain Neoplasms; Adult Brain Tumor

Summary: for patient having a brain tumor, rmi is the standard exam for tumor characterization and determines initial surgery. the aim of this study is to assess if pet could provide additional information that could have an impact on surgery (indication and planification)


Eligibility criteria:
inclusion criteria: * suspected glial resectable tumor * free and informed consent * affiliated to french social security exclusion criteria: * suspected high grade glioma * surgical emergency * pregnant or breastfeeding woman * patient deprived of their liberty or under guardianship * patient not able to follow study medical monitoring for geographical, social or psychological reasons * treated with carbidopa, catechol-o-methyl transferase inhibitor, haloperidol, reserpine within 2 weeks before pet imagery
dry needling in subjects with delayed onset muscle soreness

Conditions: Delayed Onset Muscle Soreness

Summary: investigation of the biomechanical response in delayed onset muscle soreness using dry needling vs. sham


Eligibility criteria:
inclusion criteria: * the participants of the study will be any healthy male or female between * age of 18 to 35 * able and willing to perform an exercise protocol using the gastrocnemius muscle * willing to receive either sham or dry needling intervention exclusion criteria: * current muscular pain * prior trigger point therapy in the past 6 months * medications that affect muscle function * injury in the past 6 months * any health condition that prevents exercising * recent surgery
effects of local insulin on varicose ulcers for wound healing

Conditions: Chronic Venous Disease; Varicose Ulcer; Wound Healing; Insulin; Angiogenesis

Summary: a randomized, split-plot, double-blind, placebo-controlled trial. the varicose ulcer is divided into two (side a and b). half of the wound's surface is treated locally with insulin (glargine) applied at an approx depth of 3-4 mm. treatment with insulin is administered for 7 days. biopsy specimens of the two sides are obtained on days 0 and 7. a thermographic photograph of the wound is taken at days 0 and 7. the number of blood vessels and fibroplasia is evaluated as the main outcome.

a randomized, split-plot, double-blind, placebo-controlled trial. chronic varicose ulcers measuring more than 4 cm in any of its dimensions, and that comply with candidate criteria are included in the present study. a split-mouth model is used. the ulcer is divided into two (sides a and b). the side in which treatment is applied is randomized. half of the wound's surface is treated locally with insulin (glargine) applied at an approx depth of 3-4 mm. both halves are covered with dressings and compression therapy is applied. treatment with insulin is administered for 7 days. biopsy specimens of the two sides are obtained on days 0 and 7. a thermographic photograph of the wound is taken at days 0 and 7, as control of the local temperature of the wound. this is to asses the process of healing and to correlate with our outcome measures. the number of blood vessels will be evaluated as the main outcome. fibroplasia and thermal asymmetry between wound sides will be evaluated as secondary outcomes.

Eligibility criteria:
inclusion criteria: * any gender * presence of varicose ulcer in lower extremities with a size greater than 25 cm2 * absence of infection exclusion criteria: * presence of diabetes or glycated hemoglobin \>6.5% * comorbidities that affect wound healing * malnutrition * active smoking

Keywords: varicose ulcer wound healing insulin angiogenesis
clinical investigation to assess the safety and efficacy of the laser for the treatment of vulvovaginal atrophy

Conditions: Vulvovaginal Atrophy

Summary: the purpose of this study is to assess the safety and the efficacy of a laser in the treatment of vulvovaginal atrophy (vva), that is to assess the change in the severity of the vaginal dryness symptom, by means of a visual analogic scale (10 cm vas).

the laser handpiece (probe) will be deposited in the vaginal canal and the laser energy will be delivered through the handpiece. subjects will receive a total of three (3) treatments every six (6) weeks (+/-1 week). subjects will return one week (+/- 3 days) post the first treatment, as well as three (3) months (+/- 2 weeks) and twelve (12) months (+/- 2 weeks) post the third treatment.

Eligibility criteria:
inclusion criteria: * healthy non-smoking post menopausal women with absence of menstruation of at least 12 months * exhibiting vva symptoms * prolapse staged \< ii, according to the pelvic organ prolapse quantification (ics-pop-q) system * have not had procedures in the anatomical area through 6 months prior to treatment * understand and accept the obligation and is logistically able to present for all scheduled follow-up visits exclusion criteria: * • acute or recurrent urinary tract infection (uti), or genital infection (e.g. herpes candida). * prolapse staged ≥ ii, according to the pelvic organ prolapse quantification (ics-pop-q) system * any serious disease, or chronic condition, that could interfere with the study compliance * previously undergone reconstructive pelvic surgery * have used vaginal creams, moisturizers, lubricants or homeopathic preparations for at least 3 months * a history of thrombophlebitis * a history of acute infections * a history of heart failure * received or is anticipated to receive antiplatelets, anticoagulants, thrombolytics, vitamin e or anti inflammatories within 2 weeks pre treatment * any medical condition, that, in the investigator's opinion would interfere with the patient's participation in the study * taking medications that are photosensitive * a history of keloid formation
cone beam ct for breast imaging

Conditions: Breast Imaging; Breast Cancer

Summary: the objective of this pilot study is to investigate cone beam computed tomography imaging (cbct), with the primary goal, the accumulation of a body of evidence to provide preliminary data for a future extensive clinical trials.


Eligibility criteria:
normal group: inclusion criteria: * are at least 40 years of age of any ethnicity * had a routine mammogram, read as bi-rads® 0, 1, 2 or 3 * will undergo study imaging no later than six months from date of routine mammogram. * is able to undergo informed consent. exclusion criteria: * pregnancy * lactation * patients with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker. * patients who are unable to tolerate study constraints. * patients who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to) * treatment for enlarged thymus gland as an infant * irradiation for benign breast conditions, including breast inflammation after giving birth * treatment for hodgkin's disease * patients who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * patients who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) * tuberculosis * severe scoliosis diagnostic group: inclusion criteria: * women who are at least 40 years of age of any ethnicity * have a palpable abnormality detected by breast self exam (bse), or clinical breast exam (cbe) or have a non-palpable abnormality detected by an imaging modality * after diagnostic work-up are categorized as bi-rads® 4 or 5. * are scheduled for biopsy either by large gauge needle biopsy or excisional biopsy. * will undergo study imaging prior to biopsy and within four weeks of diagnostic work-up. exclusion criteria: * pregnancy * lactation * patients who have already undergone biopsy for the index lesion * patients who are unable or unwilling to undergo biopsy for the lesion of concern * patients with physical limitations that may prohibit the patient from resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker. * patients who are unable to tolerate study constraints. * patients who have received radiation treatments to the thorax or breast area for malignant and nonmalignant conditions, such as (but not limited to) * treatment for enlarged thymus gland as an infant * irradiation for benign breast conditions, including breast inflammation after giving birth * treatment for hodgkin's disease * patients who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * patients who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) * tuberculosis * severe scoliosis
treatment of acne keloidalis nuchae (razor bumps behind the neck) using uv light therapy

Conditions: Acne Keloidalis Nuchae

Summary: this study is being done to evaluate the effect of targeted uv-b (a component of sunlight) on the treatment of acne keloidalis nuchae (akn, or razor bumps on the back of the neck). the investigators believe targeted uv-b is a safe and effective way to reduce the appearance of akn.


Eligibility criteria:
inclusion criteria: * age 18 or over * male gender * african-american or other black ethnicity * current diagnosis of acne keloidalis nuchae (razor bumps on back of neck) exclusion criteria: * allergy to lidocaine or numbing medicine * history of increased sensitivity to sunlight, lupus, or porphyria * current use of a drug that increases sensitivity to sunlight
effects of different parental involvement on anxiety and delirium

Conditions: Anxiety State; Child Behavior

Summary: induction of anesthesia in surgical procedures can be a distressing process for both children and their parents. nonpharmacological behavioral interventions, unlike sedative medications, can reduce children's anxiety without adverse effects. the effect of having both parents present during anesthesia induction on children's anxiety and parents' anxiety has not yet been documented. this study will aim to evaluate the effect of having both parents present during anesthesia induction on children's and parental anxiety during the perioperative period.

surgery can be very stressful for patients, especially children. studies show that 50-75% of children experience fear and anxiety when undergoing surgery and being put under anesthesia. this anxiety can have adverse effects on their recovery, leading to more extended hospital stays, increased pain, and behavioral issues. to address this, various medical and non-medical approaches are used to ease children's fears. one such approach is allowing parents to be with their children until the anesthesia takes effect. this study aims to assess how having both parents present during this time impacts the child's anxiety levels. the effect of parental presence on the anxiety of children and parents was studied in various studies. whether both parents affect anxiety has not been studied yet. in this study the investigators will evaluate the anxiety of children by using mypas.

Eligibility criteria:
inclusion criteria: * 80 children of both sex, aged 5-12 years with asa physical status i-ii will be enrolled exclusion criteria: * mentally challenged * deaf child * cerebral palsy * premedicated child * language problem * uncooperative * history of psychiatric disease in children or the parents * previous surgery or anesthesia history

Keywords: anxiety children anesthesia,general
a non-inferiority trial on pain relief during oocyte retrieval

Conditions: Infertility

Summary: the objective of the trial is to compare fentanyl and midazolam vs diazepam and pethidine in terms of the pain levels and post-operative side effects of tugor

in-vitro fertilization / embryo transfer (ivf / et) is a well-established method to treat various causes of infertility. it involves multiple follicular development, retrieval of oocytes and embryo transfer after fertilization. egg retrieval at the majority of ivf units is performed through the transvaginal route under ultrasound guidance (tugor) \[1\]. during tugor, the needle has to pass through the mucosa in the vaginal vault in order to puncture the follicles in the ovary. the procedures are generally short, lasting about 20-30 minutes but are still painful without anaesthesia or analgesia. intravenous sedation with or without local anaesthesia is the most widely used method. conscious sedation is a safe and cost-effective method of providing analgesia and anesthesia for tugor. \[2\] it is easy to administer in cooperative and motivated patients. it has a relatively low risk for adverse effects on oocyte and embryo quality and pregnancy rates. \[3\] paracervical block (pcb) in conjunction with conscious sedation during tugor was shown to significantly reduce the pain during tugor when compared to pcb alone \[4\]. a cochrane review on various methods of sedation and analgesia for pain relief during tugor has shown no single method or delivery system appeared superior for pregnancy rates and pain relief. \[5\] most of the methods seemed to work well and the effect was usually enhanced by addition of another method such as pain relief with paracervical block. \[6\] the investigators' reproductive centre has recently aligned with the assisted reproduction centre of the university of hong kong (hku). the investigators are using 0.1mg fentanyl and 5mg midazolam intravenously for pain relief in tugor at kwong wah hospital (kwh) whereas 5mg diazepam and 25mg pethidine intravenously are being used in hku. the investigators would like to compare fentanyl and midazolam vs diazepam and pethidine in terms of pain levels and post-operative side effects of tugor in this prospective non-inferiority randomized double-blinded trial. the investigators postulate there are no differences in the pain levels between two groups but the postoperative side effects may be different.

Eligibility criteria:
inclusion criteria: * presence of both ovaries; * body mass index less than 30 * written informed consent and * chinese exclusion criteria: * ivf cycle converted from ovulation induction or intrauterine insemination cycles; * patient requests general anaesthesia for tugor; * history of drug sensitivity to lignocaine/fentanyl/midazolam/diazepam/pethidine; * less than 3 dominant follicles present; * dominant follicles present in one ovary only and * tugor performed on one side only.

Keywords: fentanyl midazolam pethidine diazepam