Kornimate/medical-research-clean huggingface dataset:
immune status of elderly population admitted in an acute geriatric unit

Conditions: Aging

Summary: ageing is associated with vulnerability against infections leading to increased morbidity with risk of death. innate and adaptive immunities are altered with ageing responsible of deficits in immune response against pathogens and after vaccination, and favouring the elderly vulnerability against a new pathogen with increased bacterial, viral, and fungal infections. if immunity has been widely studied in immunosenescence, there are few prospective, comparative studies with elderly ill patients. moreover among these studies, pathologies are not well defined. the main objective of our project is to compare the immune state of elderly hospitalised subjects in an acute geriatric unit to the immune state of elderly healthy subjects selected with strict criteria, in order to precise the impact of polypathology and of various pathologies on immunity state.


Eligibility criteria:
inclusion criteria: * subject of 75 or more years old, female or male * subject admitted in the service of short stay gériatrique of the hospital holy marguerite, whatever is the motive for admittance * subject not being under supervision(guardianship), nor guardianship * subject benefiting from a benefit system * subject having given its assent of participation or for which the reliable person gave her assent in the case of vulnerable person exclusion criteria: * subject of less than 75 years old * subject refusing to participate in the study or for whom(which) the reliable person refuses the participation of the subject

Keywords: elderly population
study on the mechanism of eating disorder

Conditions: Anorexia Nervosa; Bulimia Nervosa

Summary: eating disorders (eds) are severe chronic psychiatric disorders with a not fully understood etiopathogenesis. previous studies have revealed some biological mechanisms of eds. however, the etiology and maintenance mechanism of eds, especially the neuro-mechanisms is still unknown. to explore the pathogenic mechanism and treatment biomarkers of eds, we design this study. the multidimensional data including the clinicopathological features, neuroimaging data (functional and structural magnetic resonance imaging), electroencephalogram and inflammatory cytokines will be used to investigate the biomarkers for diagnosis and treatment effectiveness.


Eligibility criteria:
inclusion criteria: anorexia nervosa 1. anorexia nervosa according to diagnostic and statistical manual of mental disorders (5th edition) (dsm-5); 2. age: 13-35 (including 13 and 35) 3. bmi: 13-17.5kg/m\^2 4. the participants and/or their legal guardians ( for participants who are younger than 18-year-old) sign the informed consent form voluntarily and agree to participate in all visits and examinations as required by the trial protocol. 5. do not take any psychiatric medications in past one month. bulimia nervosa 1. bulimia nervosa according to diagnostic and statistical manual of mental disorders (5th edition) (dsm-5); 2. age: 13-35 years old (including 13 and 35) 3. the participants and/or their legal guardians ( for participants who are younger than 18-year-old) sign the informed consent form voluntarily and agree to participate in all visits and examinations as required by the trial protocol. 4. do not take any psychiatric medications in past one month. exclusion criteria: 1. patients who meet dsm-5 diagnostic criteria for other mental disorders: major depressive disorder, anxiety, obsessive-compulsive disorder, personality disorder, mental retardation; drug and/or alcohol dependence; 2. patients who receive repetitive transcranial magnetic stimulation (rtms) or modified electroconvulsive therapy (mect) treatment in past six months. 3. patients with severe suicidal tendencies or suicidal behavior 4. pregnant or lactating women; 5. patients with mri contraindications; 6. patients who are regarded as unsuitable by investigators for this clinical trial.

Keywords: eating disorder anorexia nervosa bulimia nervosa functional magnetic resonance imaging eeg
the verify study: an observational study called verify to learn more about the use of vericiguat in people with chronic heart failure with reduced ejection fraction

Conditions: Chronic Heart Failure With Reduced Ejection Fraction

Summary: this is an observational study in which the health data of people with chronic heart failure with reduced ejection fraction (hfref) are collected using administrative claims data. in observational studies, only observations are made and participants do not receive any advice or changes to healthcare. chronic hfref is a longterm condition that occurs when the heart is weak and cannot pump enough blood to the rest of the body with each heartbeat. this leads to a reduced supply of oxygen which the body requires to function properly. the common symptoms include breathlessness, weakness, fatigue, and swelling in the ankles and legs. if left untreated, heart failure can lead to other serious health problems, including damage to other organs, which may result in hospital stays and even death. vericiguat works by increasing the activity of an enzyme called soluble guanylate cyclase (sgc), which relaxes the blood vessels and allows more blood to flow through. as a result, the heart is able to pump better. vericiguat was approved for the treatment of hfref based on the results of a study called victoria. the victoria study showed that vericiguat helps in lowering the chances of death or hospitalization due to heart failure. there is limited information available about the use of vericiguat for the treatment of hfref under realworld conditions. the main purpose of this study is to collect information about the characteristics of people with hfref, who are on vericiguat in addition to at least one standard treatment. researchers will collect information about participants' basic characteristics, including their age, gender, other health conditions they may have, and the medicines they may be taking. the data will come from administrative claims data for people in the united states of america who were diagnosed with hfref between january 2020 and june 2022. in this study, only available data from routine care is collected. no visits or tests are required as part of this study.


Eligibility criteria:
inclusion criteria: * ≥18-years old and have at least one year of continous enrollment in the hv database. * have proven or presumed hfref * have received ≥1 gdmts for hfref * all patients will be required to have continuous enrollment in the healthverity data set during the pre-index date (baseline period) of at least 90-days.

Keywords: hfref
gip/glp-1 co-activity in subjects with overweight and type 2 diabetes: lowering of food intake

Conditions: Type 2 Diabetes Mellitus; Overweight and Obesity

Summary: the primary aim of the study is to evaluate how gip receptor activation influence food intake and mechanisms regulating food intake in obese individuals with type 2 diabetes that are in steady treatment with metformin and a glp-1 receptor agonist.

the study is designed as a double blinded cross-over study with two study days: one day of gip infusion (for 5 hours) and one day with placebo (saline) infusion (for 5 hours). the primary endpoint is difference in food intake between the two study days. food intake is examined as amount of food eaten during an ad libitum meal.

Eligibility criteria:
inclusion criteria: * caucasian men * age between 18 and 70 years * body mass index (bmi) between 25 and 40 kg/m2 * type 2 diabetes (diagnosed according to the criteria of the world health organization) with hba1c \<69 mm (\<8.5 %) * in stable treatment for ≥3 months with metformin ≥1 g and a glp-1 receptor agonist. * informed consent exclusion criteria * anaemia (haemoglobin outside normal range) * any current or prior gastrointestinal disease that may interfere with the endpoint variables * liver disease (alanine aminotransferase (alat) and/or serum aspartate aminotransferase (asat) \> 2 times normal values) or history of hepatobiliary disorder. * nephropathy (serum creatinine above normal range and/or albuminuria). * anorexia, bulimia or binge eating disorder * allergy or intolerance to ingredients included in the standardised meals * tobacco smoking * treatment with other glucose lowering drugs than glp-1 receptor agonists and metformin. * any regular drug treatment (besides metformin and glp-1 receptor agonists) that cannot be discontinued for a minimum of 12 hours * any physical or psychological condition that the investigator feels would interfere with trial participation
the flemish umbilical nitinol mesh trial, a multicenter trial

Conditions: Umbilical Hernia

Summary: the use of mesh in the repair of umbilical hernias is a gold standard. the best location of the mesh remains a matter of discussion, i.e. it might be placed inside the peritoneal cavity (open intraperitoneal onlay mesh) or between the peritoneum and the muscle layers, so not in contact with the viscera (retromuscular or preperitoneal). the rebound mesh consists of polypropylene, i.e. the most used fabric for meshes, in combination with a nitinol memory ring. this ring allows the surgeon to position the mesh more flat, with less wrinkling and subsequently better tissue ingrowth. it also saves time for both patient's anesthesia and the surgery. this type of mesh (one coated with ptfe for intra-abdominal use and one pure polypropylene for preperitoneal use), will be used in this multicentric trial, to evaluate the best procedure in terms of efficacy, safety and postoperative complications.


Eligibility criteria:
inclusion criteria: * written informed consent from the patient or his/her legal representative * primary umbilical hernia requiring elective surgical repair * diameter between 0 and 3 cm exclusion criteria: * no written informed consent * incisional hernia at the level of the umbilicus * recurrent umbilical hernia, as they have to be considered an incisional hernia * emergency surgery (incarcerated hernia) * pregnancy * non-compliance

Keywords: umbilical hernia
strength training for elderlies and their effects on muscle fatigue and microcirculation - randomized clinical trial

Conditions: Aging

Summary: the purpose of this study is to verify the effects of a strength training program on functional capacity, muscle performance and microcirculation in the elderly.

purpose the primary research question is: do muscular strength training programs can improve functional capacity, muscle performance and microcirculation in the elderly? hypothesis: strength training program will promote electromyographic changes during the development of peripheral muscle fatigue and microcirculatory blood flow contributing to functional autonomy. secondary research questions 1. does the strength training program in the elderly improve the standard of electromyographic fatigue? hypothesis: elderly practitioners of strength exercise program showed increased neuromuscular efficiency and electromyographic fatigue index. 2. do the strength training program in the elderly improve peripheral microcirculation? hypothesis: a regular program of strength exercise in the elderly increases the blood flow in peripheral microcirculation changing the process of muscle fatigue. these biomechanical and physiological changes contribute to increased functional autonomy and reducing the risk of falls in the elderly.

Eligibility criteria:
inclusion criteria: * sedentary elderly * individuals who have physical and medical conditions to perform strength training * individuals who participate in the open university maturity program exclusion criteria: * individuals who do not have physical and medical conditions to perform strength training

Keywords: microcirculation electromyography motor activity
comparison of two different lipid emulsions for parenteral nutrition in preterm infants

Conditions: Preterm Infants; Parenteral Nutrition n-3 Fatty Acids

Summary: the study shall provide evidence for the save and efficient use of a fish oil containing lipid emulsion in parenteral nutrition of preterm infants.safety will be assessed by monitoring hepatological and hematological laboratory parameters. efficiency will be assessed by monitoring of inflammatory parameters.


Eligibility criteria:
inclusion criteria: * prematurity (birth weight 500 - 1500 g) * postnatal age \<= 72 h * need for cumulative parenteral energy supply of at least 70% during study duration * signed informed consent form exclusion criteria: * simultaneous participation in another clinical study * platelet count below 50000 /ml * cumulative enteral energy supply of \> 30 % during study duration * serious congenital infections and/or diseases * serious metabolic disturbances * severe cranial bleeding (papile iii, iv) * need for administration of blood products * contra-indication for iv lipid administration * withdrawal of consent

Keywords: n-3 polyunsaturated fatty acids (pufa) parenteral nutrition preterm infant
clinical efficiency of natural herbal based gel.

Conditions: Oral Ulcer

Summary: this clinical trial was conducted in school of dentistry, islamabad from 15th june 2023 to 16th january 2024. a total 202 participants took part in study and were divided equally into two groups i.e control group and experimental group where control group was not given any treatment for oral ulcer whereas experimental group was given herbal based denpro oral gel 2-4 times a day for at least 4 weeks topically on ulcer area. mouth ulcer size in patients was measured on first day " visit=0", second day " visit=1", third day " visit=2", fourth day " visit=3", seventh day " visit=4" and fourteenth day " visit=5" for reduction and complete recovery. data was analyzed by one way anova and post hoc tukey test.

this clinical trial was conducted in school of dentistry, shaheed zulfiqar ali bhutto medical university for the period of six months from 15th june 2023 to 16th january 2024. ethical approval was taken from the ethical review board committee of the hospital with the letter # sod/erb/2023/43-01. the participants volunteered in the study after the brief explanation about the aims and objectives study. these participants were enrolled in the study after receiving their informed written consents. total 202 participants took part in the study and did show up during the entire follow up period of the study. 54 males and 148 females participated in this clinical trial after their confirmation of not having allergy to any type of medication. these patients were divided into two groups i.e control group and experimental group. control group was not given anything but experimental group was given denpro oral gel (gennec health sciences pvt, ltd, karachi, pakistan) for treating the ulcer 2-4 times a day for at least 2 weeks. they were instructed to apply the gel topically on the ulcer area with the help of finger or applicator after the meals or before sleeping. moreover, they were forbidden to use any other medication for the treatment of the oral mouth ulcer to avoid the bias. mouth ulcer size in both the control group and experimental group was measured on the first day " visit=0" which was taken as the baseline, again measured on second day " visit=1" , third day " visit=2" , fourth day " visit=3" , seventh day " visit=4" and finally, fourteenth day " visit=5". these multiple visits were carried out for checking the reduction in its size and complete recovery of the oral mucosa without using anything in control group and after the application of the gel in the experimental group.

Eligibility criteria:
inclusion criteria: * mouth ulcer size greater than 2mm that appeared within 48 hours. exclusion criteria: * mouth ulcer size lesser than 2mm that did not appear within 48 hours.

Keywords: ulcer herbel gel
evaluation of clinical success of bulk fil composite versus highly viscous glass ionomer in primary class ii molars

Conditions: Dental Caries Class II

Summary: evaluate the clinical performance of equia forte ® ( a hvgic) and plafique® bulk flow composite resin when placed in class ii cavities in primary molars.

1. thorough diagnosis of patients will be done by the primary investigator. patients with class ii carious primary molars with score 4 or 5 using the international caries detections and assessment criteria (icdas). 2. pre-operative bitewing radiographs will be obtained to assess the depth of the cavity. primary molars with score d1 or d2 according to the ada will be included in the study. 3. each patient will be assigned to one of the two groups. * group i (n= 59): plafique bulk flow composite. * group ii (n=59): equia forte group. 4. class ii carious primary molars are prepared using 330 burs. the cavity will be approximately with a depth of 0.5 mm in dentin and width of at least one-third of the occlusal table. outline of the cavity will be determined by the extent of the carious lesion. no beveling will be done in any of the cavities. 5. matrix is placed and secured in position. 6. one of the 2 restorative materials is placed in the cavity using the manufacturer's instructions. 7. patients will be recalled at 3, 6, and 12 months to evaluate the restoration clinically using the fdi criteria. 8. patients will receive oral health education on how to maintain a proper oral hygiene and proper diet consumption. 9. they will be given manual tooth brushes and tooth pastes to use during the study.

Eligibility criteria:
inclusion criteria: * four to 8 years old children * cooperative children classified as class 3 or 4 based on frankle et al. classification. * presence of deep bite or any type of malocclusion or parafunctional habits. * children who have at least one primary molar with active proximal caries (score 4 or 5 using icdas). exclusion criteria: * refusal of the parents to sign the informed consent. * presence of deep bite or any type of malocclusion or parafunctional habits.

Keywords: hvgic proximal caries bulk-fil flowable composite
predictive factors for male sexual dysfunction after traumatic spinal cord injury

Conditions: Male Sexual Dysfunction; Spinal Cord Injury

Summary: objective: to analyze the association between sexual function of men with spinal cord injury with possible predictive factors for dysfunction.

method: observational study (caae 41221414.5.0000.5208) conducted with 45 men, mean age 34 (ci 31.5 to 37.1), with spinal cord injury and active sex life. sexual function was assessed by the international index of erectile function and level and degree of injury were determined following the guidelines of the international standards for neurological and functional examination classification of spinal cord injury. descriptive statistical techniques were applied and multivariate analysis using logistic regression adjusted to observe the association between factors, with 0.05 significance level.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of traumatic spinal cord injury, injury time less than six months heterosexual and sexually active exclusion criteria: * patients who had erectile dysfunction attributed to endocrine or metabolic disease order, those who underwent surgery in the genital area, such as radical prostatectomy or penile implant and cognitive impairment

Keywords: sexuality spinal cord injuries penile erection erectile dysfunction psychological sexual dysfunctions
the assessment of movement disorders utilizing live two-way video

Conditions: Tardive Dyskinesia

Summary: the purpose of this project is to determine the equivalency of extrapyramidal symptoms (eps) and tardive dyskinesia (td) examinations conducted via live two-way video versus live examinations completed in-person

extrapyramidal symptoms (eps) and tardive dyskinesia (td) are one of the most frequent and troublesome adverse events when taking antipsychotic agents. the investigators aim in this study to determine if the investigators can conduct examinations for eps and td remotely using live two-way video. it is potentially beneficial for patients, especially those who are located far away from psychiatrists if they could be seen by trained clinicians and assessed for eps and td via two-way video in the future. participants will be asked to have a medical assessment which consists of simple questions and some examination of their movements via two-way video and in person. the investigators will compare the results of video examinations with the results of live examinations.

Eligibility criteria:
inclusion criteria: * inpatients and outpatients aged 18-75 years old who have been taking antipsychotics for longer than 6 months in their life time, and * that have been compliant for the past week. exclusion criteria: * patients who have medical conditions which make it difficult to perform a physical examination. * patients who are clinically too ill to consent and/or unable to cooperate with the examination procedures.

Keywords: schizophrenia extrapyramidal symptoms tardive dyskinesia two way video assessment
the effect of dietary interventions, or no intervention, on pain and quality of life in women diagnosed with endometriosis

Conditions: Endometriosis

Summary: this prospective pilot study was performed to explore the influence of a dietary intervention, the low fodmap diet or endometriosis diet, on endometriosis-related pain and quality of life (qol). participants could choose between adherence to a diet; the low fodmap diet or endometriosis diet, or to contribute to the control group and not adhere to a diet.

this prospective pilot study was performed to explore the influence of a dietary intervention, the low fodmap diet or endometriosis diet, on endometriosis-related pain and quality of life (qol). participants could choose between adherence to a diet; the low fodmap diet or endometriosis diet, or to contribute to the control group and not adhere to a diet. women choosing to adhere to a diet were extensively guided by a dietician in training. in addition, both groups are asked to complete three questionnaires over a period of six months; once every two months.

Eligibility criteria:
inclusion criteria: * women diagnosed with endometriosis, either through radiologic imaging (transvaginal ultrasound and/or mri) or laparoscopy * a reported pain score of ≥ 3 (visual analogue score (vas), scale 0-10cm) in one or more of the following symptoms: dysmenorrhea, deep dyspareunia and chronic pelvic pain exclusion criteria: * about to undergo an operation within six months * undergone an operation in the past six weeks * a switch in hormonal therapy within six weeks * women that were pregnant or breastfeeding * women diagnosed with a malignancy * an additional diagnosis with coeliac disease (cd) and/or lactose intolerance. * not sufficient in the dutch or english language.
validation of dna methylation biomarkers for oral cancer detection

Conditions: Oral Cancer; Recurrence

Summary: the purpose of this study is to investigate the correlation between dna methylation and the treatment and recurrence of oral cancer.

in this study, investigators plan to recruit 40\~50 patients who had, or currently has oral cancer. the study procedures are as below: * after the informed consent form is signed, swab from the lesion site and normal site to obtain oral epithelial cells. * collect tissue from the tumor site and the non-cancerous matched site from the surgery or the tissue bank. * collect oral swab from the lesion site and the normal site when patients return to the clinic for a regular follow-up. specimens will be collected for dna methylation testing, and the results will be compared with patient's clinical diagnosis. it is expected that the relationship between dna methylation, oral cancer, and the recurrence of oral cancer will be found.

Eligibility criteria:
inclusion criteria: * age between 20 and 75 years old * had or currently has cancer of the oral cavity * agree to sign the informed consent form (icf) and comply with follow-up procedures exclusion criteria: * unwilling to sign the informed consent form (icf) * has an autoimmune disease of the oral cavity

Keywords: primary oral cancer dna methylation recurrence oral cancer