Kornimate/medical-research-clean huggingface dataset:
evaluation of efficiency for three different aligning archwires during initial orthodontic leveling

Conditions: Dental Malocclusion; Dental Crowding

Summary: the present prospective clinical study was directed to evaluate the efficiency of three different aligning archwires during initial orthodontic leveling.

the present prospective clinical study was directed to evaluate efficiency of three different aligning arch wires during initial orthodontic leveling. the sample of present study included 30 patients, 15 females and 15 males; with a mean age was 17.81 ± 1.96 years. they were randomly allocated into three equal groups, according to the type of the aligning arch wire as follows: 1. group a: in which 10 patients, with a mean age was 17.27 ± 1.95 years, were treated with conventional singlestrand niti arch wires. 2. group b: in which 10 patients, with a mean age was 17.33 ± 2.42 years, were treated with niobium-titanium-tantalum-zirconium (gummetal) arch wires. 3. group c: in which 10 patients, with a mean age was 18.70 ± 1.49 years, were treated with multistrand niti arch wires. mandibular orthodontic study models were taken every 4 weeks and laser scanned to obtain 3d digital models during the 3 months observation period of the study. the changes in lii were determined at every 4 weeks observation intervals. moreover, the changes in inter-canine, inter-1st premolar and inter-molar widths before and after three months were evaluated and compared among the three groups of aligning arch wires. data were collected and statistically analyzed via statistical package for social science (spss, version 23). one way anova and kruskall-wallis tests were used to assess the difference among the three studied groups and paired t-test was used to assess the difference and percent of changes within each group before and after three months observation period.

Eligibility criteria:
inclusion criteria: * an age range from 15 to 20 years * all permanent teeth have erupted (3rd molar not included) * angle class i malocclusion with normal facial proportions. * moderate crowding in the lower dental arch that required treatment with fixed appliance using the non-extraction approach. * good oral hygiene with healthy periodontium, good general health without any systematic disease that could affect the treatment. exclusion criteria: * severe crowding that requires an extraction approach. * a blocked-out tooth that prevent the easy placement of the bracket at the initial bonding appointment. * poor oral hygiene or periodontal compromised teeth. * relevant medical history and/or regular medication that contraindicates and/or interferes with orthodontic treatment. * craniofacial anomalies or previous history of trauma, bruxism, or parafunction. * previous orthodontic treatment.

Keywords: orthodontic arch wire alignment gummetal arch wire multistrand arch wire
safety and efficacy study of sjp-0035 ophthalmic solution in patients with moderate to severe corneal epithelial disorders

Conditions: Corneal Epithelial Disorders

Summary: the purpose of the study is to determine if sjp-0035 ophthalmic solution is effective in promoting corneal epithelial wound healing in conditions associated with corneal epithelial disorders.

there is currently no product approved for corneal epithelial wound healing. a phase 1 study sjp-0035/1-01 was conducted in healthy volunteers to investigate the safety, tolerability, and pharmacokinetic profile of sjp-0035 ophthalmic solution and to determine the appropriate dose to be evaluated in patients with moderate to severe corneal epithelial disorders. this phase 2a study is being conducted to evaluate the safety and efficacy of sjp-0035 ophthalmic solution in patients to promote corneal epithelial wound healing in conditions associated with corneal epithelial disorders.

Eligibility criteria:
inclusion criteria: * male or female between the ages of 18 and 75 years, inclusive. * has moderate to severe superficial punctate keratitis (spk) and/or corneal erosion in 1 or both eyes. * has symptoms caused by corneal epithelial disorders. * has not obtained improvement from previous treatment for the spk or corneal erosion within the last 30 days. * is a female of childbearing potential with a negative pregnancy test result at screening and baseline and agrees to use effective contraception throughout the study or is a postmenopausal woman with a negative pregnancy test result at screening and baseline. exclusion criteria: * has any corneal stromal or endothelial abnormalities including an active bacterial or viral ocular infection, bullous keratopathy, or chemical burns or any trauma to the cornea. * any active or chronic allergic, bacterial, or viral infection of ocular adnexa and eye structures. * had previous ocular/refractive surgery (including laser surgery) within the last 6 months. * has used any ocular medication (except mydriatics, stain, and topical anesthesia used for study assessments) within 14 days prior to the first dose of study drug, or who are anticipated to require such medications during the study. artificial tears may be used up to 72 hours prior to the first dose. * is unable to discontinue restasis. a 28-day washout period prior to the first dose of study drug is required. * is a contact lens wearer and cannot discontinue use for the duration of the study. * alcohol or drug abuse within the past 6 months. * positive hepatitis b surface antigen, hepatitis c virus antibody, or human immunodeficiency virus test at screening.
enhanced lithotripsy system (els) in the treatment of urinary stone disease

Conditions: Urinary Stone

Summary: this is a single arm, multi-center study to assess the safety and efficacy of a form of extracorporeal lithotripsy, called the enhanced lithotripsy system, to treat urinary stones.

this is a single arm, multi-center study to assess the safety and efficacy of a form of extracorporeal lithotripsy, called the enhanced lithotripsy system, to treat urinary stones. subjects will be treated up to 2 times with the enhanced lithotripsy system and followed for 90 days after the last treatment session.

Eligibility criteria:
inclusion criteria: * male or female aged ≥ 18 years to ≤ 75 years. * one urinary stone-apparent on a computed tomography (ct) scan within 14 days prior to study enrollment * stone size, as estimated by pre-procedure ct, with all dimensions 15 mm or less. * provides written informed consent * understands and accepts the study requirements exclusion criteria: * age less than 18 years of age or over 75 years of age * diagnosis of radiolucent stones * diagnosis of stones in the lower pole of kidney * history of cystinuria * urine ph below 5.5 * current untreated urinary tract infection * pregnancy * coagulation abnormality or taking prescription anticoagulants. aspirin usage will be discontinued at least 7 days prior to enrollment at the discretion of the attending physician. * mobility issues - unable to comfortably lie still for up to 30 minutes or unable to roll from back to side * known hypersensitivity to conductivity gel * vulnerable individuals (mentally disabled, physically disabled, prisoner, etc.) * body mass index greater than 35 * american society of anesthesiologists (asa) score of 3 or greater general anesthesia risk level * known sensitivity to possible medications used before, during, or after the els procedure, including but not limited to the following: sedative agents, general anaesthetics, topical anaesthetics, and opioid analgesics. * enrollment in another research study or previous participation within 30 days of enrollment.

Keywords: lithotripsy urinary stone
a safety study of ustekinumab in the treatment of pediatric participants aged 6 years and older with moderate to severe plaque psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to monitor the long-term safety of ustekinumab in pediatric participants (6 years to 17 years of age at the time of inclusion) with moderate to severe plaque psoriasis, through monitoring for the following adverse events potentially related to immune modulation: serious infections, malignancies and autoimmunity; and to monitor the long-term effects of ustekinumab on growth (weight, height, body mass index) and development (sexual maturity based on the tanner scale).


Eligibility criteria:
inclusion criteria: * have a confirmed diagnosis of moderate to severe chronic plaque psoriasis * either start therapy with ustekinumab for the treatment of psoriasis within 2 months after the first assessment in the study or have started therapy with ustekinumab in the 12-week period before the first assessment in the study; a. the treatment decision must have been taken independently of and prior to a participant's inclusion in the study; b. where participants have started therapy with ustekinumab before the first assessment in the study, appropriate baseline data at the start of ustekinumab treatment must be documented, including psoriasis area and severity index (pasi), physician global assessment of disease (pga), body surface area (bsa) and children's dermatology life quality index (cdlqi) scores where available * participants (and/or a legally-acceptable representative/guardian where applicable) must sign a participation agreement/informed consent form (icf) allowing source data collection and verification in accordance with local requirements and the participants (and/or a legally-acceptable representative/guardian where applicable) must be able to understand and complete the requested patient-reported outcomes (pros) * be willing to participate in the study exclusion criteria: * is enrolled in an interventional clinical trial
effect of heartmath intervention on stress, emotional vitality and sense of coherence

Conditions: Stress; Coherence Sense

Summary: this study aims to investigate the effect of heart math intervention program on stress, emotional vitality and sense of coherence among intensive care units nurses

this study aims to investigate the effect of heart math intervention program on stress, emotional vitality and sense of coherence among intensive care units nurses. the intervention was implemented in form of 2 sessions per week according to the following 7 sessions, each session about 45- 60 minutes. session (1) aims: introduce heart math definition of stress. assess client's current stress level. handouts for patients: handout 1 : stress what is stress? how stress affect health? how stressed are you? what can i do about it? session (2) aim: introduce concept of heart coherence handouts for patients: handout 1: heart coherence how dose heart math work? how can i create and practice physiological coherence? the quick coherence technique. handout 2: depletion to renewal plan. session (3) aims: teach heart-focused breathing and quick coherence introduce personal practice plan to use for handouts for patients: handout 1: heart-focused breathing. handout 2: quick coherence technique. handout 3: personal practice log. session (4) aims: assess client's current anxiety level. review this week's homework on personal practice log. review and practice quick coherence technique. teach heart lock-in technique. handouts for patients: handout 1: anxiety checklist. handout 2: quick coherence technique. handout 3: heart lock-in technique. handout 3: personal practice log. session (5) aims: review this week's homework on personal practice log. review heart-focused breathing and quick coherence techniques. review and practice. heart lock-in technique. teach freeze frame technique. handouts for patients: handout 1: heart lock-in technique. handout 2: freeze frame technique. session (6) aims: review this week's homework on personal practice log. review heart lock-in and freeze frame techniques. teach attitude breathing technique. handouts for patients: handout 1: personal practice log. handout 2: freeze frame technique. handout 3: attitude breathing technique. session (7) aims: review this week's homework on attitude breathing technique. teach coherence communication technique. handouts for patients: handout 1: attitude breathing technique. handout 2: coherent communication technique.

Eligibility criteria:
inclusion criteria: * nurses who work in selected intensive care units and agree to participate exclusion criteria: * nurses who refuse to participate in this study
trial to evaluate the efficacy of a manualized reflective writing program for clinical phase physician assistant (pa) students.

Conditions: Burn Out; Student Burnout; Physician Assistant Student Burnout

Summary: the following will be an open label controlled efficacy trial of the effects of longitudinal participation in an existing reflective writing program for medical students on burnout in physician assistant students.

the pilot of the reflective writing workshop for pa students will follow the existing curriculum used for the md program. the workshops will run for 75 minutes with additional time at the end of the session to complete a post-intervention assessment survey. planning and adaptation of the program materials will be conducted by a group of pa students and the current md-student leaders of the reflective writing program under the guidance of dr. anna reisman. all pa student participants will be split up into 1-2 groups of 6-10 students based on the number of participants. sessions are expected to be held in-person pending covid-19 guidance and will be held in reserved classroom space in the pa program building (100 church street south) or in reserved conference rooms at the cushing-whitney medical library. trained pa and/or md student facilitators will then use prepared materials to guide each group through a series of prompts, each eliciting written reflections of varying lengths. while all participants are encouraged to reflect, write, and share their responses, participation at all levels remains optional. facilitators will not solicit any participants for a response. all program participants will be asked to complete a brief post-assessment survey consisting of short-answer and likert scale questions about their attitudes towards program participation. responses collected will be used to assess the feasibility and acceptability of the program for pa students and as feedback to guide potential future implementation of the program.

Eligibility criteria:
inclusion criteria: * able to offer consent * able to speak and read english. * must be a student in yale physician associate program class of 2024 exclusion criteria: -
effects of change in insulin resistance and systemic inflammation on brain structure and function

Conditions: Obesity; Bariatric Surgery Candidate

Summary: obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for alzheimer's disease and vascular dementia. the mechanisms underlying obesity related decline in cognitive function are not fully understood. the long-term goal of this project is to understand how obesity affects cognitive function, with the aim to develop new ways to prevent and treat obesity related cognitive decline

a growing body of evidence suggests that obesity is associated with alterations in brain structure and cognitive impairment. mid-life obesity is a risk factor for alzheimer's disease and vascular dementia. the mechanisms underlying obesity related decline in cognitive function are not fully understood. the long-term goal of this research is to identify how obesity, insulin resistance (ir), and their treatment impact brain structure and function. the investigators propose that ir and obesity related inflammation are two modifiable factors that affect neuronal integrity and lead to cognitive dysfunction. in this proposal, investigators will test two hypotheses: 1) among obese patients planning to undergo bariatric surgery (specifically vertical sleeve gastrectomy), baseline ir and systemic and brain markers of inflammation will inversely correlate with performance on cognitive testing and correlate with abnormalities in brain structure and 2) following bariatric surgery subjects who experience the greatest reduction in ir and obesity related inflammation will have the greatest improvement in cognitive function and brain structure. to address these hypotheses, investigators will use a comprehensive battery of tests to evaluate cognition and state of the art magnetic resonance imaging (mri) techniques to assess brain structure and neurochemistry before and six months after bariatric surgery.

Eligibility criteria:
inclusion criteria: obese group * undergoing vsg-type bariatric surgery * bmi \> 30 * current weight less than 400 lbs non-obese group * age 30-50 * bmi \< 25 exclusion criteria: both groups * history of type 1 or type 2 diabetes * history of stroke * history of epilepsy * history of neurosurgical procedures * past or current history of severe psychiatric illness * pass or current history of alcohol or substance abuse * absence of metallic substances in body or ability to remove before imaging procedure * history of claustrophobia or known inability to tolerate mri * inability to consent
validation of the turkish version of the pain sensitivity questionnaire

Conditions: Pain

Summary: the pain sensitivity questionnaire(psq) is a self-rating measure for the assessment of pain sensitivity and has been developed by dr. r. ruscheweyh in germany. it consists of 17 items rated from 0, not at all painful to 10, most severe pain imaginable. the validation of the turkish version of psq is needed, in order to measure pain sensitivity among turkish people.


Eligibility criteria:
inclusion criteria: * asa 1-2 * adult chronic low back pain patients having pain for greater than 3 months exclusion criteria: * failed back surgery syndrome, * morbid obesity (body mass index, \>40), * being a non-turkish speaker, * substance abuse disorder, * major psychiatric disorder (eg, severe depression, bipolar disorder, axis ii personality disorder, and schizophrenia).

Keywords: pain sensitivity
photo-therapy with a topical retinoid versus photo-therapy alone for actinic keratoses

Conditions: Actinic Keratoses

Summary: evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy for the treatment of actinic keratoses.

evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy vs photodynamic therapy alone for the treatment of actinic keratoses.

Eligibility criteria:
inclusion criteria * adults aged 18-80 years old * subjects with ak lesions who will receive pdt * subjects with ak lesions in two areas other than face and scalp each with a surface area of 10cm2 or greater and at least 3 clinically diagnosed non-hypertrophic ak lesions in each * subjects in good health * subjects with willingness and the ability to understand and provide informed consent exclusion criteria * subjects who are pregnant or lactating * subjects with a history of cutaneous photosensitivity or porphyria, hypersensitivity to porphyrins, or photodermatosis * subjects with use of photosensitizing drugs within 1 week of study start * subjects with use of topical medications such as corticosteroids, alpha-hydroxyacids or retinoids 2 weeks before study entry * subjects who received previous treatment of target aks within 4 weeks * subjects who are unable to understand the protocol or give informed consent

Keywords: actinic keratoses blue light therapy photosensitizer retinoid
effects of myofascial release with and without thiele massage

Conditions: Dyspareunia; Pain; Quality of Life

Summary: dysperunia is caused by chronic discomfort during sexual intercourse causing pain during vaginal intercourse.sexual pain causes relationship decreasing quality of life following anxiety and depression.myofascial techniques with and without thiele massage will be used via randomised controlled trial following sample size of 38.

dyspareunia is characterised by recurring or chronic discomfort during sexual intercourse that causes distress. dyspareunia can be superficial, causing pain when vaginal insertion is tried, or profound. women who experience sexual pain are more likely to experience sexual dysfunction, relationship distress, decreased quality of life, anxiety, and depression. one in five nulliparous women (a female who has never given birth to a baby) experiences moderate dyspareunia. myofascial pain is typically treated using manual manipulation (manual manipulation involves using skilled, hands-on maneuvers to perform soft tissue mobilization, myofascial release and more) or thiele massage. in this study the aim is to find the individual and combined effect of these techniques. the study will be randomized controlled trial (rct). non probabiity convenient sampling technique will be used to assign randomly half of patients in group a for the experimental group and half in group b who will meet the inclusion criteria. group a will include participants who will receive myofascial releases and thiele massage. whereas group b will include participants who will receive myofascial releasing techniques but not thiele massage. both group will have 1 session per week for 12 weeks. numeric pain rating scale, female sexual function index, functional pelvic pain scale would be used as an outcome measure tools. the collected data will be analyzed in statistical package for the social sciences (spss) 25

Eligibility criteria:
inclusion criteria: age 23-40 1. dyspareunia symptoms for more than 6 months 2. females with tenderness of pelvic muscles from last 6 months 3. nulliparous women exclusion criteria: 1. any pelvic organ prolapse 2. any current genital malignancy 3. cases of chronic pelvic pain due to any other issue 4. any traumatic conditions around the pelvis and lower limbs, any infectious, tumors conditions around the pelvis. 5. pregnant females 6. any lower limb abnormalities, any recently underwent abdominal and low back surgery.

Keywords: dyspareunia pelvic floor disorder pelvic pain myofascial release technique pelvic floor
amplification and selection of antimicrobial resistance in the intestine

Conditions: Acute Leukaemia

Summary: the worldwide increase in the incidence of multidrug-resistant (mdr) pathogens is alarming. antimicrobial treatment is a risk factor for the isolation of mdr pathogens and can therefore contribute to the observed trend. differences in the degree of selection pressure caused by various antimicrobials have not been systematically investigated until today. the aim of the proposed project is the determination of the impact of antibiotic treatment on the copy number of resistance genes in the human intestinal microbiome using metagenome shotgun sequencing. the resistance gene count in the gastrointestinal tract will be determined in a clinical cohorts of patients treated with either ciprofloxacin or cotrimoxazol as monotherapy. the subsequent quantification and comparison of the selection pressure facilitates the application of antibiotics with a lower potential to select for resistance. to achieve this goal, a self-controlled, prospective observational epidemiological study will be performed at two centres of the german centre for infection research (tübingen, cologne).


Eligibility criteria:
inclusion criteria: * male or female patients ≥ 18 years * patients with acute leukaemia * admission to one of the 2 study centres * obtained written consent exclusion criteria: * treatment with antibiotics in the previous 30 days * pregnancy * patients currently treated for hiv and/or hepatitis b/c * patients who can not estimate scope and consequences of their participation in the study * patients who will most likely not be able to follow the study protocol

Keywords: metagenomics antimicrobial resistance multidrug resistance