Kornimate/medical-research-clean huggingface dataset:
effect of gemigliptin or acarbose on endothelial function in type 2 dm patients

Conditions: Endothelial Function; Type 2 Diabetes; Gemigliptin; Acarbose

Summary: this is a phase 4, single center, randomized, open-labeled study. the primary objective of the study is to compare effect of gemigliptin and acarbose on endothelial function. subjects are randomized to gemigliptin or acarbose group and maintained intial treatment for 4 weeks.


Eligibility criteria:
inclusion criteria: * age: 20-80yrs * patients with type 2 diabetes (duration of diabetes \>=3 months) * hba1c :\>7.0 and \<=9.0% on metformin monotherapy * no changes on medications during recent 3 months. exclusion criteria: * patients with type 1 diabetes * history of medications including α-glucosidase inhibitor, glinide, glp-1 analogue, other dpp-4 inhibitors, or insulin during recent 3 months. * history of acute diabetic complication, acute coronary events, or coronary bypass surgery/interventions during recent 6 months. * patients with congestive heart failure (nyha ii\~iv) or clinically significant ventricular arrhythmia * serum alt or ast\> 2.5 x upper normal range * serum direct bilirubin \> 1.3 x upper normal range * serum creatinine \> (men) 1.5 mg/dl, (women)\>1.4 mg/dl * smoker * pregnant women, or breast-feeding women * medication with acetylsalicylic acid or vitamin k antagonist
study of computer attention training programs in schools for children with attention deficit/hyperactivity disorder

Conditions: Attention Deficit Hyperactivity Disorder

Summary: this study examines the efficacy of two computer-based attention training systems, one with and one without neurofeedback. the training systems intend to help children learn to focus and attend more effectively.

the current study is examining a neurofeedback (nf) computer attention training system that teaches children to alter their brainwave activity with a cognitive training attention training system (ct). the investigators hypothesize that both treatments will show improvement in adhd symptoms and academic outcomes compared to a control condition. 104 children with adhd in grades 2 and 4 are randomly assigned to receive the nf, ct, or a waitlist-control (wlc) condition that receives nf or ct the following academic year. children receive forty 45-minute sessions three times a week at school for 4 months. a comprehensive assessment, consists of data completed by teachers, parents, participants, and double-blind classroom observations.

Eligibility criteria:
inclusion criteria: * diagnosis of adhd (any subtype, per report of the child's physician or school psychologist) entering 2nd or 4th grade at the beginning of september 2009 and 2010. * combined iq (intelligence quotient) at or above 80, * ability to read english sufficiently to complete assessments and intervention protocols exclusion criteria: * mental retardation, * coexisting diagnosis of conduct disorder, * pervasive developmental disorder, or * other serious mental illness (eg., bipolar disorder, psychosis, autism)

Keywords: adhd neurofeedback biofeedback computer attention training
en masse distaliaztion via skeletal anchorage

Conditions: Orthodontic Appliance Complication, Angle Class II Patients, Distalization

Summary: comparing the efficacy and performance of two conventionally anchored distalizers after modifying them to be skeletally anchored. en masse distalization is attempted by consolidating the posterior maxillary segment "first premolar to second molar" as one unit.


Eligibility criteria:
inclusion criteria: * full set of permanent teeth present, except for third molar * bilateral class ii malocclusion with a mesial migration of maxillary posterior teeth * no systemic conditions interfering with treatment, as reported by patient * no previous orthodontic treatment * good oral hygiene * no use of any for of anti-inflammatory drugs exclusion criteria: * patient who required surgery to correct skeletal discrepancies * patient with congenital dentoskeletal disorders * missed or mutilated teeth in maxillary arch * patients with poor oral hygiene
comparison of safety and efficacy of two different drug eluting stents implanted into saphenous vein grafts

Conditions: Stenosis in Saphenous Vein Graft, Drug Eluting Stent

Summary: drug eluting stents significantly reduced the rate of in-stent restenosis in coronary arteries. there are several kinds of des i.e. eluting the drug either from stable or biodegradable polymer. the type of the polymer may impact the clinical outcome. the aim of our study was to compare safety and efficacy of implantation of two different types of stents eluting paclitaxel from stable vs biodegradable polymer (taxus stent vs luc-chopin stent) into coronary artery by-pass graft.


Eligibility criteria:
inclusion criteria: 1. atherosclerotic lesion in saphenous vein grafts causing angiographic stenosis ≥70% 2. stable coronary artery disease or non st segment elevation acute coronary syndrome 3. reference segment diameter in range of 2.5-4.5mm exclusion criteria: 1. cardiogenic shock 2. contraindications to prolonged dual antiplatelet therapy 3. female of child birth potential unless on effective contraception 4. other medical condition that may limit survival

Keywords: saphenous vein graft, taxus stent, chopin stent
randomized trial of crenolanib in subjects with d842v mutated gist

Conditions: GIST With D842V Mutated PDGFRA Gene

Summary: this is a multicenter, randomized, double-blinded, placebo-controlled, trial of oral crenolanib versus oral placebo in combination with best supportive care in subjects with advanced or metastatic gist with a d842v mutation in the pdgfra gene. approximately 120 subjects will be randomized in a 2:1 ratio to receive either crenolanib 100 mg or matching placebo orally (po) 3 times daily (tid) in combination with best supportive care.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically-confirmed advanced or metastatic gist with a d842v mutation in the pdgfra gene as determined by central laboratory testing 2. measurable disease as per modified recist 1.1 • a lesion in an area that was previously treated with local therapy (e.g. radiation, surgery, or cryotherapy) can be considered measurable disease as long as there is objective evidence of progression of the lesion prior to randomization 3. subjects (male or female) ≥ 18 years of age 4. female subjects with reproductive potential must have negative serum or urine pregnancy test 5. eastern cooperative oncology group (ecog) performance status of ≤ 2 exclusion criteria: 1. severe liver disease (e.g. cirrhosis, non-alcoholic steatohepatitis, sclerosing cholangitis) 2. known, active infection with hepatitis b virus (hbv) or hepatitis c virus (hcv) 3. female subject who is pregnant or breastfeeding, or planning to become pregnant within 30 days after ending treatment 4. systemic anti-cancer treatment (e.g. chemotherapy, tyrosine kinase inhibitors, immunotherapy, or investigational agents) or investigational device within 3 weeks or 5 half-lives (if the drug's half-life in subject is known) prior to randomization, whichever is shorter
procalcitonin in hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the value of serum procalcitonin in differentiation between bacterial infection and non infectious inflammation in febrile hcc patients following locoeregional treatment for hcc.


Eligibility criteria:
inclusion criteria: 1. - hepatocellular carcinoma patients who will undergo tace and/or radio-frequency. 2. - fever more than 38c after 48 hours post intervention. exclusion criteria: 1. hcc patients who does not develop fever after intervention. 2. proven infection elsewhere (e.g. uti, chest infection..)

Keywords: hepatocellular carcinom postablation syndrom procalcitonin
the continuing care needs in colorectal cancer patients in different stages

Conditions: Colorectal Cancer

Summary: the aims of this study are to: 1. explore supportive care needs in colorectal cancer patients with treatment and survivors; 2. compare the supportive care needs in different stage of colorectal cancer; 3. identify the significant factors for the supportive care needs; 4. explore the supportive care needs within one year after newly diagnosis.

both large scale cross-sectional survey and a prospective 1-year longitudinal panel study design will be used in this study. the cross-sectional survey is to examine the current status of supportive care needs perceived by different stage of colorectal cancer inpatients and outpatients including survivors. the 1-year longitudinal design is to explore the change of supportive care needs perceived by patients within one year after newly diagnosed with colorectal cancer.

Eligibility criteria:
inclusion criteria: * patients with colorectal cancer in any stage or survivors * those who are willing to participate in the research * aged above 18 exclusion criteria: * none

Keywords: colorectal cancer needs survivors any stage
use of on-q pump for pain post c-section

Conditions: Pain

Summary: the main purpose of this study is to examine if pain levels treated with intrathecal (it) preservative-free morphine (pfm) after a cesarean section improve with the additional use of continuous subfascial wound infiltration with ropivacaine using the onq® elastomeric pump system.

the main purpose of this study is to examine if pain levels treated with intrathecal (it) preservative-free morphine (pfm) after a cesarean section improve with the additional use of continuous subfascial wound infiltration with ropivacaine using the onq® elastomeric pump system. as a double-blinded, randomized, placebo controlled study, women undergoing first, second or third cesarean section will be randomly assigned to one of 3 different groups. group 1 will receive saline, group 2 will be given ropivacaine 0.1%, group 3 will be given ropivacaine 0.2%, all at a rate of 8ml/hr via the onq® pump system. each group will also receive an 8ml bolus of the previously assigned infusate. the investigator will assess pain at rest and with movement at different time periods during the recovery process through 3 months post operatively. the investigator will also assess if the use of this system decreases the need for other pain medications and reduces the potential side-effects of pain treatment.

Eligibility criteria:
inclusion criteria: 1. female patients at emory university hospital midtown undergoing non-emergent, scheduled or unscheduled first, second or third cesarean sections 2. patients who are american society of anesthesiology (asa) class i-iii 3. patients are at least 34 weeks pregnant 4. patients to receive spinal anesthesia for their procedure 5. patients who are 18 years of age or older 6. patient willing and able to provide written informed consent exclusion criteria: 1. patients with 3 or more prior cesarean sections 2. patients undergoing emergent cesarean section with or without general anesthesia 3. patients with known allergy to morphine, ketorolac, and/or amide local anesthetics 4. patients who will not receive spinal anesthesia 5. patients who are less than 34 weeks pregnant 6. patients with significant maternal cardiac, liver or renal disease 7. patients with maternal history of narcotic abuse or dependency 8. patient with pre-operative fever (\>100.4 degrees f) 9. patients less than 18 years old

Keywords: analgesia cesarean section opiates
tailored written lifestyle feedback in colorectal cancer screening

Conditions: Lifestyle; Diet Habit; Smoking Cessation; Physical Activity; Alcohol Drinking; Body Weight

Summary: this randomized controlled trial aims to investigate the effect of an individually tailored lifestyle feedback letter and a leaflet on lifestyle in the context of sigmoidoscopy screening.

cancer screening may be used as a teachable moment for healthy lifestyle behaviours. this study aims to investigate the effect of minimal, but individually tailored lifestyle advice and a standard leaflet on healthy lifestyle given at a colorectal cancer screening context on one-year changes in these behaviours in a population-based sample of men and women. individuals invited to sigmoidoscopy screening in the piloting of norwegian bowel cancer screening are additionally invited to this lifestyle intervention study. changes in lifestyle are measured by a brief lifestyle questionnaire administered at prescreening and after one year. the intervention to the intervention arms is given after completion of the prescreening lifestyle questionnaire.

Eligibility criteria:
inclusion criteria: * invited to sigmoidoscopy screening in the norwegian bowel cancer screening pilot study exclusion criteria: * excluded from sigmoidoscopy screening due to medical reasons, previous colorectal cancer diagnosis, relocating out of the screening municipalities or previous colonoscopy in the last 12 months.

Keywords: lifestyle intervention diet smoking cessation physical activity alcohol body mass index colorectal cancer screening sigmoidoscopy
clinical cardiovascular outcomes of african-americans

Conditions: Cardiovascular Diseases; Heart Diseases

Summary: to examine clinical cardiovascular outcomes of african americans.

background: it has been well recognized for years that the survival rates among african-americans with chronic diseases are reduced compared to their white counterparts. recently attention has focussed on racial disparities in survival with chronic cardiovascular diseases. prior to the widespread availability of coronary arteriography, african-americans were thought to have a very low incidence of coronary artery disease. these findings appear to be inconsistent with the now generally accepted view that the coronary artery disease mortality rate is nearly equal in united states black and white men and is increased in black women as compared to white women. howard university and howard university hospital provided a unique environment for studying the clinical cardiovascular outcomes of african-americans, in light of its history. that is, due to the influx of blacks into the district of columbia in 1862, freedmen's hospital (which is now known as howard university hospital) was established for their care. howard university hospital has had an admissions profile with greater than 95 percent african-americans for the past century design narrative: the study used previously collected data to: 1) examine the trends in mortality rates at howard university hospital, based on discharge status, between 1986 - 1992, for selected cardiovascular diseases; 2) compare cardiovascular mortality rate trends between howard university hospital and the national hospital discharge data; 3) examine cardiovascular co- morbidity experiences using a severity of illness index at howard university hospital compared to national data by race/ethnicity, geographic location and hospital bed size; and 4) identify a cohort of cardiovascular patients retrospectively based on repeated discharge data at howard university hospital, to analyze survival data. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
basivertebral nerve block during vertebral augmentation: an alternative approach to intraprocedural pain management

Conditions: Vertebral Compression; Vertebra Compression Fracture; Vertebral Fracture

Summary: the goal of this study is to assess the efficacy of lidocaine basivertebral nerve block as intraprocedural anesthesia during vertebral augmentation procedures.

vertebral compression fractures secondary to osteoporosis can be treated with vertebral augmentation. since intraprocedural pain is common during vertebral body endplate manipulation, these procedures are often carried out using conscious sedation or general anesthesia. research has shown that the vertebral endplates are innervated by the basivertebral nerve, which has been successfully targeted via radiofrequency ablation to treat chronic vertebrogenic lower back pain. with this physiology in mind, the investigators will attempt to treated participants with vertebral compression using lidocaine-induced intraosseous basivertebral nerve block as the primary intraprocedural analgesia.

Eligibility criteria:
inclusion criteria: * age \>50 years old * patient must have a diagnosis of osteoporosis on dual energy x-ray absorptiometry (dexa), * patient must have an acute or subacute single level vertebral compression fracture between t10 - l3 as confirmed via magnetic resonance imaging (mri) or nuclear medicine bone scan, * patient must have an initial pain score of greater than or equal to five using a standard 0-10 visual analog scale subjective pain score upon initial consultation. exclusion criteria: * pathologic compression fracture, such as due to metastatic disease * age \>90 years old or \<50 years old * pregnancy * diagnosed anxiety disorder * diagnosed depression disorder * diagnosed psychotic disorder * diagnosed mental disease disorder * diagnosed parkinson's disease/other movement disorders/or cerebellar dysfunction * eastern cooperative oncology group (ecog) score at baseline prior to compression fracture \>1 * back pain scores at time of initial consult \<5, using a standard visual analog scale * illicit drug dependence or abuse * alcohol dependence or abuse

Keywords: basivertebral nerve block vertebral augmentation bvn block kyphoplasty nerve block compression fracture
virtual reality distraction for anxiety reduction during trigger points procedures in pain medicine clinic

Conditions: Pain Management

Summary: this study aims to evaluate the effect of virtual reality (vr) as a distraction method to help those patients undergoing trigger points therapy to reduce anxiety and increase patient satisfaction. half of the participants will wear vr gear, meanwhile the other half will be in control group, which will not wear vr headset, only the normal care.

trigger points can cause a wide range of pain symptoms; pain in the anterior shoulder and down the arm, headache pain, back pain, hip pain, knee pain, frozen shoulder pain, and other symptoms. local anesthetic injections and lidocaine injections are common "wet" needling treatments for trigger points injections. the proposed mechanism by which trigger points injections alleviate pain is based on mechanical disruption of the taut bands of muscle with palpation based needling. during injections, patients may feel an intensified pain and a twitch response. distraction has been proved to be an effective tool in pain management, and it can also be used for a variety of medical procedures. by engaging in assigned tasks, pain and anxiety are assumed to be lessened throughout the procedure, while leaving patients less occupied by pain stimuli. . an immersive virtual environment may be preferable to medications such as sedatives, due to side effects and prolonged discharge from procedure suite. occasionally, medications may not even be available in a busy interventional pain suite. at the ucd pain clinic, we do not offer sedating medications for bedside procedures like trigger point injections. by wearing vr headset, patients may feel less tense, anxious, and painful during trigger point injections.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years old, who are referred to uc davis pain medicine clinic and are candidates for trigger point injections, are english speaking and can understand oral and written instructions exclusion criteria: * patients who have high risk of motion sickness, seizure disorder, visual/hearing impairment, prisoners or are pregnant are not eligible for this study.

Keywords: virtual reality trigger point injections
studying genes, environment, and prostate cancer risk in patients with or without prostate cancer

Conditions: Hereditary Prostate Cancer; Prostate Cancer

Summary: rationale: gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer. purpose: this research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.

objectives: * to determine the association between variation in genes involved in ros detoxification, oxidative stress response, and prostate cancer risk. * to determine the association between fatty acid levels and prostate cancer risk. outline: probands undergo blood and saliva sample collection for fatty acid, dna, and polymorphism analyses. archived blood and tissue samples from probands who previously participated in dr. shannon's diet and prostate cancer risk study are also analyzed. medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results. all probands completed the "genetic risk easy assessment tool family history of cancer" and "diet history and environmental risk factor" questionnaires at baseline. if a proband previously participated on our diet and prostate cancer risk study, he was asked to complete the "changes in diet, prescriptions, supplementals and herbal remedies" questionnaire in addition to the "genetic risk easy assessment tool family history of cancer" questionnaire at baseline for this study. projected accrual: a total of 750 participants will be accrued for this study.

Eligibility criteria:
disease characteristics: * meets 1 of the following criteria: * prior diagnosis of prostate cancer or negative prostate biopsy and previously participated in dr. shannon's diet and prostate cancer risk study and consented to future studies (proband) * referred to the portland va medical center urology clinic for a prostate biopsy (proband) * introduced to this study by a proband or found to be related to a proband who is part of a homogenous high-risk subgroup after completion of the family history of cancer analysis patient characteristics: * see disease characteristics prior concurrent therapy: * see disease characteristics

Keywords: hereditary prostate cancer prostate cancer
extracellular vesicles and particles (evp) as biomarkers of recurrence in non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: the purpose of this study is to find out if fluid rinsed from peoples' airways (bronchial washing samples) during routine surgery to remove (resect) their non-small cell lung cancer (nsclc) tumors contains enough vesicles to do testing that may help the researchers learn more about their nsclc.


Eligibility criteria:
inclusion criteria: * all patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible. * patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis. exclusion criteria: * patients with active infection or pneumonia which may impact exosome makeup * additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced

Keywords: extracellular vesicles and particles biomarkers 22-155