Kornimate/medical-research-clean huggingface dataset:
effects of social media usage on pain catastrophizing and disease impact in female patients with fibromyalgia syndrome

Conditions: Fibromyalgia

Summary: the aim of this study is to investigate the effects of social media usage on pain catastrophizing and disease impact in female individuals diagnosed with fibromyalgia syndrome.

in this study, the total number of female patients obtained as a result of sample size calculations was 73, and the effect of social media use on pain catastrophizing and disease impact of patients diagnosed with fibromyalgia will be investigated. social media use will be evaluated with the social media use integration scale, disease impact with the fibromyalgia impact questionnaire, anxiety levels with the beck anxiety inventory, and pain catastrophizing level with the pain catastrophizing scale. at the same time, a form including demographic data of the patients will be filled. the results will be evaluated with the tests prescribed by the statistical expert, and correlation will be investigated.

Eligibility criteria:
inclusion criteria: * giving consent. * being diagnosed with fibromyalgia syndrome * being female exclusion criteria: * not giving consent. * any disability or illness that may prevent filling out the form or communicating.
adherence to electrical glossal in situ stimulation for sleep apnea (aegis study)

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this research is to assess how well people with mild obstructive sleep apnea (osa) adhere to the exciteosa device and specifically examine whether adherence of the device is different with low versus high electrical stimulation. in addition, this research study will assess how well the device affects mild sleep apnea and if it improves sleepiness and quality of life.


Eligibility criteria:
inclusion criteria: 1. age greater than 18 years 2. ability to consent 3. home sleep apnea test demonstrating mild obstructive sleep apnea. 4. smartphone or tablet exclusion criteria: 1. current pacemaker, defibrillator, or neuro-stimulation device 2. no prior oropharyngeal surgery for sleep apnea 3. no implants, metal prostheses, dental braces, or soft tissue/bony ulcerations in the oral cavity 4. no prior use of mandibular advancement device (mad) or continuous positive airway pressure (cpap) 5. heart failure (new york heart association class 3 or 4; or ejection fraction \< 45%) 6. active coronary disease defined as an intervention (e.g., angioplasty, coronary artery bypass surgery) in the prior 6 months 7. uncontrolled hypertension (bp \> 160/100) 8. clinician diagnosis of any chronic lung disease except asthma 9. chronic fatigue syndrome or fibromyalgia 10. self-reported current illicit drug use in the past 30 days 11. self-reported use of marijuana or opiates in the past 30 days 12. use of supplemental oxygen 13. self-reported use of prescribed or over the counter sleeping medications in the past 30 days 14. current pregnancy or intention of becoming pregnant 15. oropharyngeal abnormalities (class 2 or class 3 malocclusion) 16. periodic breathing (cheyne stoke respiration) 17. central sleep apnea (central apnea index (cai) \> 5/h) 18. investigator discretion 19. prisoners
bacterial reduction and post operative endodontic-pain using different kinematics

Conditions: Root Canal Infection

Summary: this study was conducted to compare the antibacterial effect and degree of postoperative pain of single rotary and reciprocating file systems during endodontic therapy

introduction: instrumentation kinematic is one of the many aspects of shaping files that underwent heavy development through the last decade. the impact of the type of motion used to drive shaping instruments was heavily studied but mostly in-vitro. more randomized clinical trials are needed to achieve a reliable body of data concerning the issue. aim: this study aimed to evaluate the effect of varying shaping files' kinematics on bacterial reduction, post-operative pain and the incidence of flare-ups. methods: necrotic, asymptomatic, single-rooted mandibular premolars with single canals were used in the study, where 46 patients were randomly allocated to two groups. in the first group, waveone gold was used for mechanical preparation while one shape was used in the second group. samples were taken preoperatively (s1) and after chemomechanical preparation (s2). bacterial reduction was evaluated and compared between both groups via culturing technique and quantitative analysis by real-time polymerase chain reaction (qpcr). post-operative pain and the incidence of flare-ups were also evaluated using the visual analog scale (vas) method.

Eligibility criteria:
inclusion criteria: * mandibular premolars * single rooted * single canalled * necrotic pulps * asymptomatic apical periodontitis exclusion criteria: * gross caries * root/crown fracture * sinus tract * swelling * intake of antibiotics within previous 3 months * pain with percussion

Keywords: reciprocation kinematics bacterial reduction post-operative pain endodontic flare-ups
dietary fat levels and abiraterone acetate uptake in patients with metastatic hormone-resistant prostate cancer

Conditions: Adenocarcinoma of the Prostate; Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

Summary: this randomized pilot phase i trial studies the side effects of dietary fat levels and abiraterone acetate uptake in patients with metastatic hormone-resistant prostate cancer. abiraterone acetate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. eating a low or high fat diet may increase the uptake of abiraterone acetate.

primary objectives: i. to assess the dietary effects of a low fat and high fat diet at a low abiraterone acetate dose (250 mg) on drug levels compared to standard dose administered in a fasting condition. secondary objectives: i. to potentially guide decisions in the future to use low dose abiraterone in a fed state and decrease overall cost. ii. to evaluate the potential relationship between esterase activity and abiraterone metabolism in an exploratory analysis. iii. to determine the feasibility of using patient-collected dried blood spot (dbs) samples for pharmacokinetic monitoring. outline: patients are randomized to 1 of 2 treatment arms. arm i: patients receive standard dose abiraterone acetate orally (po) once daily (qd) (held on days 2, 3, 9, and 10), and low-dose abiraterone acetate po qd on days 3 and 10. patients eat a low fat breakfast on day 3 and a high fat breakfast on day 10. arm ii: patients receive abiraterone acetate as in arm i. patients eat a high fat breakfast on day 3, and a low fat breakfast on day 10.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the prostate * about to initiate or currently being treated with abiraterone acetate 1000 mg orally once daily * clinically able to receive abiraterone acetate in the opinion of the investigator in accordance with standard prescribing practices * ability to consume a low fat and high fat diet * expected duration of continuous abiraterone therapy \> 8 weeks * signed and dated informed consent exclusion criteria: * patients taking medications that strongly inhibit or induce cytochrome p450 (cyp)3a4 within 28 days prior to the start of the study will be excluded
study comparing pulmonary vein isolation with the cryoballoon, radiofrequency energy, or both in the treatment of atrial fibrillation (af)

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to perform a prospective, randomised study investigating the safety and efficacy of cryoballoon catheter ablation compared with radiofrequency ablation, or both together in the treatment of paroxysmal af. the hypotheses for this study are (1) that cryothermal energy is as effective and safe as using radiofrequency energy in the treatment of paroxysmal af and is associated with a better long term outcome, and (2) that use of both cryothermy and rf in combination is as effective and safe as using either radiofrequency energy or cryothermy alone and is associated with a better long term outcome.

pulmonary vein isolation is an important treatment for patients with atrial fibrillation (af), particularly those in whom antiarrhythmic drugs are ineffective or cannot be tolerated. one method involves the use of radiofrequency energy and 3-d mapping system to produce a series of lesions (small burn areas) within the heart. another method involves passing a balloon (called a cryoballoon) into the heart and freezing the parts of the heart muscle that the veins drain into. both methods appear to be effective from known data. however, it is not known if use of either method alone or both together is the most effective. we aim to perform a prospective, randomized clinical trial comparing these three strategies. substudy 1: use of cardiac mri to evaluate ablation lesions. some patients will also be asked to undergo an mri scan of the heart before the ablation procedure, and again at three months and one year following the procedure. this will allow us to examine the potential role for mri in imaging scar tissue formed by the ablation, and help us understand the time course of scar formation and changes to that part of the heart following the ablation. substudy 2: platelet reactivity and activation in af, and the impact of curative ablation. blood and urine samples will be taken pre- and 3 months post ablation to see if platelet reactivity and activation are affected by af compared to established normal ranges, and whether curative ablation impacts on this.

Eligibility criteria:
inclusion criteria: * patients with documented paroxysmal af on at least 2 occasions and accepted for catheter ablation. exclusion criteria * significant valvular disease * previous left atrial ablation

Keywords: catheter ablation
quality of life study of helixate nexgen

Conditions: Hemophilia A

Summary: the aim of this study is to describe health related quality of life (hrqol) in adolescents and adults with hemophilia a treated prophylactically or on-demand with helixate nexgen. the study will also assess the kinds of determinants, including key transitional life events, that might impact hrqol in this patient population.


Eligibility criteria:
inclusion criteria: * haemophilia a patient * severely (\<1%) and moderately (1-5%) affected * on treatment with helixate nexgen * ability to read and understand study materials (patient information and data protection form, patient-related questionnaires) * signed data protection form; if patient is \<18 years of age, legal guardian must also give written consent by signing the data protection form exclusion criteria: * presence of inhibitors * abuse of recreational drugs or alcohol interfering with the every-day-life in the opinion of the physician * advanced stage human immunodeficiency virus (hiv) infection (cd4 cell counts \<200/cmm, multi-drug resistance, presence of aids related signs or symptoms) * symptomatic liver disease (cirrhosis, ascites, esophageal varices) * concomitant or planned interferon therapy * malignancies on or off treatment

Keywords: hemophilia quality of life
effects of denosumab therapy for japanese

Conditions: Osteoporosis

Summary: in this study, the investigators would like to analyze the bone mineral density (bmd) , bone turnover makers, and fracture prevention effects of denosumab in japanese patients under clinical practice. the participants are treated in the investigators hospital, who are under severe osteoporotic condition. the main objective of this study is to investigate effects of denosumab. the researchers also investigate the effects of effects of previous osteoporotic therapy to denosumab treatment. in this study, the investigators analyse the determinants of subsequent bmd increase and fracture preventing effect by teriparatide.

registry criteria: patients treated in the investigators hospital using denosumab. enrolled patients are severe osteoporosis; more than two previous osteoporotic fractures, low bmd (\< young adult mean 65%). interventions: blood analyses and dual-energy x-ray absorptiometry (dxa) every 4 months informed consent: written informed consent will be obtained. sample size: five-hundreds participants

Eligibility criteria:
inclusion criteria: * osteoporotic patients exclusion criteria: * cancer, hypercalcemia, etc (i.e. patients who could not use denosumab)

Keywords: osteoporosis bmd denosumab previous therapy
knee kinematics for subjects with zimmer-biomet posterior cruciate retaining or posterior stabilizing total knee arthroplasty

Conditions: Arthroplasty, Replacement, Knee; Osteoarthritis, Knee

Summary: 25 subjects implanted with a zimmer-biomet posterior cruciate retaining (pcr) total knee arthroplasty (tka) and 25 subjects implanted with a zimmer-biomet posterior stabilizing (ps) tka will be asked to perform stepping up and deep knee bend activities while under fluoroscopic surveillance (x-ray video). the movements between the two different types of tkas will be compared.


Eligibility criteria:
inclusion criteria: * subjects will have a zimmer persona pcr or ps tka. * subjects must be at least six months post-operative. * subjects will have kss greater than 75. * participants must be able to perform the required activities - stepping up and a deep knee bend. * subjects must be willing to sign the informed consent (ic) / hipaa form to participate in the study. * bilateral subjects may be included in the subject population exclusion criteria: * pregnant, potentially pregnant or lactating females. to satisfy radiation protocol, each female subject will be asked if she is pregnant, or possibly could be pregnant. a pregnant person will not be allowed to participate in the study. to ensure this, a pregnancy test will be administered to any female participants of child bearing age who have not had a hysterectomy. * subjects without the required type of knee implant. * subjects who are unable to perform stepping up and deep knee bend. * subjects who are unwilling to sign informed consent/hipaa documents. * subjects who do not speak english and/or french
comparative effectiveness of ctc & oc

Conditions: Colorectal Cancer

Summary: the goal of this study is to compare the findings of virtual (ct-colonography) with findings of optical colonoscopies to determine if virtual colonoscopy is suitable for colorectal cancer surveillance.

the goal of this study is to compare, both clinically and from a cost-effectiveness perspective, virtual or ct-c (ct-colonography) to standard ct scan and optical colonoscopy (oc). virtual colonoscopy is a combination of a radiologic evaluation of the abdomen and pelvis with intra-colonic imaging. previous research supports the concept that ct-c may be an effective substitute for the current oc and address limited compliance for surveillance for crc survivors. post-operative crc surveillance strategies are effective, but depend upon patient compliance which is less than desired. improved adherence is linked with greater cost-effectiveness as well as better clinical outcomes. ct-c possesses potential advantages: convenience as a single test, less risk, possibly patient preference and lower total costs. costs would be reduced through direct (provision of fewer optical colonoscopies) and indirect means (reduction in time lost from work by patient and chaperone, etc.). when extrapolated across the roughly 200,000 ocs performed annually in the us for this indication reduced utilization of even 50% in a high unit cost procedure like oc would yield substantial savings without a reduction in clinical quality.

Eligibility criteria:
inclusion criteria: * patients with a history of crc without clear evidence of metastatic disease who have completed their acute cancer-specific treatment * patients aged 18 years or older * patients who have signed an approved informed consent form exclusion criteria: * patients with a diverting ileostomy, with a history of inflammatory bowel disease, fap, or active gi symptoms (gastrointestinal bleed, diarrhea, severe abdominal pain, etc.) * patients who are pregnant

Keywords: colorectal cancer surveillance
evaluating cognitive and functional impairment in alzheimer's dementia with a ketogenic diet.

Conditions: Cognitive Function 1, Social

Summary: the present study is being done in a scientifically rigorous manner, using readily available mct oil (refined from coconut oil) versus a placebo oil to assess any cognitive and functional benefits for ad patients.

the proposed study, is a randomized placebo controlled cross-over study for 6 months, with an open label extension for another 6 months designed to test the benefits and safety of mct oil in patients with established ad. it will be the first study on mct oil ever done with this design, and for this duration in ad.

Eligibility criteria:
inclusion criteria: * patients \>49years with a clinical diagnosis of ad * mini mental status examination (mmse) score 10-29/30 * on stable dose of medications for 3 months (achei, memantine and antidepressants allowed) * able to speak english * patient or designate able to sign informed consent * stable chronic medical conditions (heart disease, thyroid disease) * reliable caregiver exclusion criteria: * age \<50 years * medically unstable * unable to swallow liquids * diagnosis of diabetes mellitus * residence in a nursing/long term care home * allergy to coconut * allergy to olive oil
efficiency comparison between methylprednisolone and phenol 8% treatment using a trans sacral approach - on lower back pain and limbs

Conditions: Back Pain

Summary: the american society of anesthesiologists task force on management, chronic pain section, recommended phenol neurolysis when other techniques have failed to provide adequate pain control. in this study we sought to compare the pain relieve on a lower back and limbs obtained from methylprednisolone and phenol 8% treatment given by trans sacral approach. the study includes patients who suffers from a chronic low back and/or limbs pain which were referred to be given epidural as a treatment. control group receives 80 mg methylprednisolone while the test group receives phenol 8%.


Eligibility criteria:
inclusion criteria: -at least 18 years of age; * chronic low back pain of at least 12 weeks duration; * patients which were diagnosed as a candidate for epidural since other techniques have failed to provide adequate pain control * sciatica due to lumbar disc herniation * neurogenic claudication due to lumbar spinal stenosis exclusion criteria: * patients with unbalanced high blood pressure * patients who can not ley prone * patients who consumes anti-clotting medications * patients with bleeding problems * patients with diabetes * patients who suffers from chronic non-specific lower back and limb pain

Keywords: methylprednisolone trans sacral block phenol
evaluation of clinical decision support system for brain metastasis using brain mr images

Conditions: Brain Metastases

Summary: bt-m01 is a software that has been pre-learned based on a brain metastasis detection model using brain mr images, and clinical decision support system for brain metastasis by automatically analyzing brain mr images by assisting the medical team. the specific aims of this study are to evaluate efficacy of bt-m01 for brain metastasis compared to the sensitivity and false positive rates of radiologists group.


Eligibility criteria:
inclusion criteria: * adults over 19 years old * brain mr acquired * positive group: a patient diagnosed with brain metastasis after a brain mr * negative group: a normal person or a patient not diagnosed with brain metastasis after a brain mr exclusion criteria: * poor or incomplete brain mr image quality * a patient with other pathological lesion in brain * a patients with a history of primary brain tumors
efficacy, safety and tolerability of tri476 (oxcarbazepine) in children with inadequately controlled partial onset seizures

Conditions: Partial Onset Seizures

Summary: this study is designed to provide short term efficacy and safety data of tri476 in children with inadequately-controlled partial seizures. patients will be randomized into either drug treatment or placebo group at 1:1 ratio, and receive their respective treatment for 8 weeks. the purpose of study is to confirm that tri476 as adjunctive therapy is effective and safe.


Eligibility criteria:
inclusion criteria: * male and female outpatients, aged 4 to 14 years (inclusive), with a minimum body weight of 15 kg. * a diagnosis of partial onset seizures, which include the seizure subtypes of simple, complex, and secondarily generalized seizures (based on the international league against epilepsy (ilae) classification, as modified in 1981). exclusion criteria: * a document history of generalized status epileptics in the past 6 months. * seizures having a metabolic, neoplastic, or active infectious origin. other protocol-defined inclusion/exclusion criteria may apply

Keywords: seizures oxcarbazepine child
evaluation of the efficacy of laser acupuncture on uremic pruritus

Conditions: Uremia

Summary: sixty patients were randomly assigned to either the experimental group (n=30) receiving laser acupuncture or the control group (n=30) receiving sham laser acupuncture. treatment sessions were conducted during dialysis sessions. the experimental group received laser acupuncture at xuehai, quchi, and bai chongwo acupoints three times per week for four weeks. the control group received sham laser acupuncture at the same acupoints. the 5-d pruritus scale and dlqi were used to assess pruritus severity before and after the intervention.

the subjects were divided into two groups to investigate whether laser acupuncture can improve uremic pruritus.

Eligibility criteria:
inclusion criteria: * age ≥ 20 years. * intact parathyroid hormone (ipth) levels \< 68 pg/ml (patients with -thyroidectomy excluded). * urea nitrogen (bun) clearance rate (kt/v) ≥ 1.2 at each dialysis session. * serum phosphate levels \< 5.5 mg/dl. * receiving hemodialysis three times weekly for at least three consecutive months. * no history of acute illnesses like infections or cardiovascular disease. * avoiding a high-phosphorus diet. * adjusting dialysate calcium concentration to 8.6-10 mg/dl. * replacing the artificial kidney or increasing dialysis blood flow exclusion criteria: * pregnant or nursing. * history of photosensitivity. * recent use of systemic or local medications for pruritus (e.g., immunosuppressants, opioid agonists/antagonists, glucocorticoids, antihistamines, ultraviolet b therapy). * hepatobiliary dysfunction based on medical history and liver function tests. * malignancies. * other itchy skin conditions diagnosed by a dermatologist. * wounds near acupuncture points, contraindicating laser acupuncture

Keywords: uremia