Kornimate/medical-research-clean huggingface dataset:
hiv prevention toolkit for hiv-negative male couples

Conditions: HIV

Summary: though technology is integrated into the lives of our target population, use of any particular technology will depend on the content delivered, aesthetic appeal, and overall design. based on the completion and analysis of data from phase 1, the investigators were able to obtain feedback on hiv-negative male couples' attitudes toward the original content in the prevention toolkit modules. the research team, along with the web-developers, used this feedback to specifically tailor the content of the modules to fit the unique needs of the intervention's target population: at risk hiv-negative male couples. for phase 2, the investigators conducted focus groups at each site to help identify strengths and potential areas for improvement of the prevention toolkit, which will be incorporated before piloting it in the intervention for phase 3 of this project. after assessing the acceptability of the prevention toolkit, including the content of modules, aesthetic appeal, and overall design with hiv-negative male couples target population, the research team will pilot test whether the rct with the prevention toolkit will help reduce hiv risk through formation and adherence to a sexual agreement, reduction in occurrences of condomless anal sex with casual sex partners, and increase testing behaviors among at-risk hiv-negative male couples. the interactive website, herein referred to as the "hiv prevention toolkit" will contain unique modules about sexual agreements and effective hiv prevention strategies.


Eligibility criteria:
inclusion criteria: eligible male couples: 1. are identified as two men (i.e., main partners) who had been in a sexual relationship together for \> 6 months; 2. are at least 18 years of age; 3. are self-reported as being hiv-negative; 4. had been practicing cas in their relationship for \> 6 months; 5. report no recent history (\< 1 year) of intimate partner violence (ipv) or coercion; 6. have had no current sexual agreement; and 7. own a smartphone and have an alternate method to access the internet (e.g., computer). exclusion criteria: 1. interested participants, including both men of a male couple, who did not meet the inclusion criteria above will be excluded from participating in phase 3 of this study. 2. individuals who participated in phase 1 or 2 will be were excluded from participating in phase 3 of this study. 3. adults who are unable to consent; 4. individuals who are not yet adults; 5. pregnant and non-pregnant women, and prisoners.

Keywords: hiv prevention toolkit male couples sexual agreements
efficacy and effectiveness of peginterferon and ribavirin in korean patients with chronic hepatitis c

Conditions: Chronic Hepatitis C

Summary: the purpose of this study is to investigate the efficacy and effectiveness of peginterferon alfa-2a and ribavirin therapy in korean chronic hepatitis c patients.

a retrospective analysis of a prospective, multicenter, industry-sponsored, open-label, uncontrolled, community-based clinical trial of combination of peginterferon alfa-2a and ribavirin (pegasys expanded access program) conducted at 6 tertiary referral centers in korea between 2003 and 2004 and a cohort of hepatitis c patients who were treated in a single tertiary referral hospital (asan medical center, seoul, korea) between 2004 and 2008

Eligibility criteria:
inclusion criteria: all of below * adults aged 18-70 years * serum anti-hcv antibody (+) * hcv rna detectable by pcr * compensated liver disease (child-pugh class a) exclusion criteria: any of below * hcv genotype other than 1, 2, or 3 * acute hepatitis c * decompensated cirrhosis or hepatocellular carcinoma * other liver disease such as hepatitis a or b, or autoimmune hepatitis * hiv ab(+) * severe depression or other psychiatric disease * previous organ transplantation * absolute neutrophil count (anc) \< 1,000 cells/mm3 or platelet count \< 75,000 cells/mm3, or hemoglobin (hb) \< 13 g/dl for men, \<12 g/dl for women
joint use of electrocardiogram and transthoracic echocardiography with other clinico-biological parameters in an observational study to monitor cardio-vascular events and predict outcomes in patients diagnosed with covid-19

Conditions: COVID-19; Myocardial Injury; Myocarditis

Summary: covid-19 outbreak is often lethal. mortality has been associated with several cardio-vascular risk factors such as diabetes, obesity, hypertension and tobacco use. other clinico-biological features predictive of mortality or transfer to intensive care unit are also needed. cases of myocarditis have also been reported with covid-19. cardio-vascular events have possibly been highly underestimated. the study proposes to systematically collect cardio-vascular data to study the incidence of myocarditis and coronaropathy events during covid-19 infection.we will also assess predictive factors for transfer in intensive care unit or death.


Eligibility criteria:
inclusion criteria: - covid-19 positive patients admitted in a ward identified by positive pcr on nasal swab samples exclusion criteria: - patients who refused the use of their routine care data after information by investigators.

Keywords: coronavirus heart conditions cardio-vascular outcomes
isovue in peripheral digital subtraction angiography (dsa)

Conditions: Peripheral Arterial Occlusive Disease

Summary: no significant differences is expected in observed motion artifacts, heat or pain reported during peripheral dsa performed for diagnostic and/or endovascular therapeutic purposes.


Eligibility criteria:
inclusion criteria: * provides written informed consent; * at least 18 years of age; * scheduled to undergo peripheral dsa for the diagnosis and/or treatment of paod exclusion criteria: * pregnant or lactating female; * known allergies to one more more ingredients in wither product; * history of severe congestive heart failure (class iv); * previously enrolled or received an investigational compound within 30 days; * history of hypersensitivity to iodinated contrast agents; * renal impairment egfr \<60 ml/min/1.73m2, calculated using the mdrd study equation * any other medical condition decreasing chances of obtaining reliable data

Keywords: peripheral arterial occlusive disease (paod)
3d ultrasound microvessel imaging for breast masses

Conditions: Breast Carcinoma

Summary: this early phase i trial studies how well 3d ultrasound microvessel imaging works for the diagnosis of breast mass. the 3d ultrasound microvessel imaging technology demonstrates significantly increased vessel detection sensitivity over conventional doppler methods without the need of using contrast agents. this study may improve cancer diagnosis and reduce unnecessary biopsy on benign tumors.

primary objectives: i. optimization of imaging protocol for this new ultrasound technology. ii. investigate the diagnostic performance of the new ultrasound technology using clinically indicated biopsy as the reference standard. outline: patients undergo 3 dimensional (d) ultrasound microvessel imaging over 45 minutes. patients' medical records are reviewed.

Eligibility criteria:
inclusion criteria: * women with solid breast lesion who are scheduled for a clinically indicated ultrasound-guided biopsy. * lesion size of 3 mm or larger. * age 18 or greater. exclusion criteria: * women with previous breast surgery or breast implant. * lacking the capacity to consent. * women who are pregnant or lactating. * women who are receiving cancer therapy such as chemotherapy or radiation therapy.
a real-world study to gain clinical insights into faricimab (fareal study)

Conditions: Neovascular Age-related Macular Degeneration; Diabetic Macular Edema

Summary: the fareal study aims to evaluate the effectiveness, safety, clinical insights and treatment patterns in patients treated with faricimab, in neovascular age-related macular degeneration (namd) or diabetic macular edema (dme) in at least one eye, in real-world routine clinical practice over a 2-year patient follow-up period. additionally, the fareal study also aims to describe and evaluate health economic aspects of previous anti-vegf treatments and current treatment with faricimab.


Eligibility criteria:
inclusion criteria: * patients, as defined by local regulations and local faricimab product label, who are initiating treatment with faricimab at time of enrollment or have initiated treatment with faricimab within 3 months prior to patient enrollment, in diabetic macular edema (dme) or neovascular age-related macular degeneration (namd) in at least one eye according to the investigator's discretion in routine clinical practice for anti-vegf treatment naïve and pre-treated patients. * patients have received at least one faricimab treatment (the first dose) in the study eye. exclusion criteria: * concomitant participation of the patient in any investigational ophthalmology clinical trial that includes receipt of any ophthalmological investigational drug or procedure within the last 28 days prior to enrollment * current participation in any interventional clinical study * active ocular inflammation and/or suspected/active ocular infection in either eye * patients in whom the study eye has been treated with faricimab for more than 3 months prior to enrollment * patients treated with faricimab who have and are currently participating in patient support programs (psp) that are market research and patient support programs (map) including post trial access programs (ptap) and compassionate use programs (cup) * patients with non-ocular sight threatening disease which have an effect on the primary endpoint (e.g., apoplexia) * hypersensitivity to the active substance or any of the excipients of vabysmo (as per label)
the efficacy and safety assessment of huafu shengji ointment in patients with diabetic foot of qi deficiency and blood stasis syndrome

Conditions: Diabetic Foot

Summary: diabetic foot ulcers, as a complication of diabetes with high disability and mortality rates, have become a significant global healthcare burden and medical challenge worldwide. the clinical situation of chronic non-healing ulcers leading to repeated amputations has not yet been resolved. in preliminary clinical practice, huafu shengji ointment has been shown to significantly improve the complete healing rate of ulcer wounds. this study aims to further comprehensively evaluate the therapeutic effects of huafu shengji ointment and provide high-quality evidence.


Eligibility criteria:
inclusion criteria: - patients who meet the following criteria will be included: 1. patients who meet the diagnostic criteria for diabetic foot and have a wagner grade of 1-5. 2. it is in line with the syndrome type of qi deficiency and blood stasis in traditional chinese medicine. 3. age between 35 and 80 years 4. the patient had no serious cardiac, liver, renal insufficiency or other systemic infections. 5. no hereditary or infectious diseases, no malignant tumors, and no severe malnutrition in patients. 6. have understood the treatment modality and voluntarily signed the informed consent form. exclusion criteria: - patients who meet any of the following criteria will be excluded: 1. patients who experience severe allergic reactions to the experimental medication and cannot undergo treatment. 2. patients with poorly controlled serious conditions such as diabetic ketoacidosis, ketoacidosis, or diseases of the liver and kidneys. 3. patients with psychiatric disorders or severe depression. 4. women who are pregnant or breastfeeding. 5. patients with severe organic tumors.

Keywords: diabetic foot ulcer huafu shengji ointment qi deficiency and blood stasis syndrome randomized controlled trial
the effect of antenatal corticosteroids on the fetal thymus - a possible role in fetal immune programming

Conditions: Preterm Labor; Fetal Glucocorticoid Exposure

Summary: administration of corticosteroids is standard practice for pregnant patients at risk of preterm labour to reduce the risk of neonatal respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and neonatal mortality. however, there is an unknown effect of antenatal steroids on both fetal and neonatal immune function. the purpose of this study is to demonstrate the effect of antenatal steroids on the size of the fetal thymus gland.

women with a singleton pregnancy in the twenty-forth to thirty-fourth week of gestation who are at risk for preterm labour, requiring the administration of betamethasone twelve milligrams intramuscularly every twenty-four hours for two doses will be included in this study along with an equal number of gestational-age matched controls not at risk for preterm delivery and therefore not requiring the administration of betamethasone. a 2-d ultrasound assessment of the fetal thymus size with measurements of the maximum transverse diameter and thymus perimeter in the three-vessel view will be performed as a baseline measurement within 36 hours of the administration of the first dose of corticosteroids. for each patient enrolled, a gestational-age matched control will have a similar ultrasound assessment. these measurements will be repeated 2 weeks after the first baseline ultrasound, and then only patients who received corticosteroids will have subsequent ultrasound measurements every 2 weeks until delivery.

Eligibility criteria:
inclusion criteria: * women with a singleton pregnancy in the twenty-forth to thirty-fourth week of gestation who are at risk for preterm labour, requiring the administration of betamethasone twelve milligrams intramuscularly every twenty-four hours for two doses will be included in this study along with an equal number of gestational-age matched controls not at risk for preterm delivery and therefore not requiring the administration of betamethasone. exclusion criteria: * chronic use of steroids during pregnancy for other indications * delivery less than 1 week from enrollment * confirmed chorioamnionitis or preterm premature rupture of membranes.
a psychological and behavioral intervention for post-bariatric patients

Conditions: Obesity

Summary: the study is designed to test a pilot intervention for bariatric patients who are starting to regain weight after the 1st year post-surgery. dialectical behavior therapy (dbt), an empirically supported therapy for borderline personality disorder, has also successfully been applied to patients with substance use and binge eating problems. the purpose of this study is to develop and test a group intervention based on dbt and cognitive behavioral therapy (cbt) techniques for patients engaging in these maladaptive behaviors after surgery with co-occuring weight gain.

weight regain post bariatric surgery may be due to anatomical, physiological, or psychological and behavioral factors. one potential psychological and behavioral contributor to poor weight loss outcome following bariatric surgery may be low distress tolerance, characterized by emotional reactivity to stressors and lack of appropriate emotional regulation, and using eating, drinking, or other substances to improve mood. recent research indicates that a subset of patients post-surgery experience challenges with subjective bulimic episodes, graze eating, and alcohol misuse; evidence for poorer excess weight loss (ewl) outcomes is associated with graze eating and uncontrolled eating behavior. this submission is for a pilot project designed to examine the impact of participation in a dialectical behavior therapy (dbt) plus cognitive behavioral therapy intervention delivered post-surgery on weight, psychological, and behavioral outcomes after roux-en-y gastric bypass surgery (rygb) for patients experiencing weight regain relapse with co-occuring disordered eating or substance misuse behaviors.

Eligibility criteria:
inclusion criteria * regained ≥ 15% of total post-surgical weight lost * has either disregulated eating, drinking, or misuse of chemical substance * age 18-75 * ability to participate in group * completed first roux-en-y gastric bypass procedure at mayo clinic exclusion criteria * patients with an uncontrolled psychiatric diagnosis * patients severely impaired by drug or alcohol use * completed surgical intervention at location other than mayo clinic * more than one bariatric procedure

Keywords: bariatric obesity post-surgery intervention
the influence of simple, low-cost chemistry intervention videos: a randomized trial of children's preferences for sugar-sweetened beverages

Conditions: Obesity; Type 2 Diabetes; Dental Caries

Summary: sugar-sweetened beverage (ssb) consumption is associated with the development of obesity, type 2 diabetes, and dental caries. the current study attempts to explore whether an educational, science-based intervention is able to produce a measurable negative change in preferences for sugar-sweetened beverages, as well as initiate plans to reduce future ssb consumption in 12-year old children. in the first condition (ssb intervention), participants will watch a video showing the decay of an egg in various ssbs (coca-cola, sprite, gatorade, and apple juice), followed by the evaporation of these beverages over a heat source, revealing their sugar content. in the second condition (water intervention), participants will watch a video showing an egg maintaining its shell in water, followed by the evaporation of water. in the third condition (control), participants will watch a video of an egg maintaining its shell in rubbing alcohol, followed by the evaporation of rubbing alcohol. before and after watching their assigned video, participants will complete survey questions to assess self-reported: ssb consumption intentions, attitudes toward ssbs, and health perceptions of ssbs. therefore, the aims of this study are to (1) quantify changes in ssb consumption intentions, attitudes towards ssbs, and health perceptions of ssbs from pre-video to post-video, (2) establish the effectiveness of the ssb intervention and water intervention over the control, (3) establish the effectiveness of the ssb intervention over the water intervention, (4) determine the efficacy of incorporating scientific evidence in a public health intervention, and (5) make recommendations for the future application of the method employed in this intervention to future public health campaigns.


Eligibility criteria:
inclusion criteria: * we will recruit a nationally representative sample of participants through the subdivision of qualtrics, qualtrics panel. participants must be 12 years old and english speaking. exclusion criteria: * any participant that is not 12 years old or does not speak english will be excluded from participation.
heart rate variability during acute diverticulitis

Conditions: Acute Diverticulitis

Summary: the purpose of this study is to investigate heart rate variability during acute uncomplicated diverticulitis by ecg-monitor (holter), the investigators hypothesis is the inflammation causes a decrease of high frequency(hf)-power component of heart rate variability and this correlates with sleep quality and daytime fatigue.

an increasing number of studies have shown that circadian variation in the excretion of hormones, the sleep-wake cycle, the core body temperature, the tone of the autonomic nervous system and the activity rhythm are important both in health and disease processes. the investigators are interested in investigating the heart rate variability (hrv) during an acute surgical non-inflammatory condition, and to exam whether there are correlations between: hrv and sleep stages, hrv and cytokine levels in blood and hrv and subjective fatigue. following methods will be applied device: holter monitor - medilog ar12 (oxford instruments, oxford, england) other: karolinska sleepiness scale other: physical fatigue scale device: polysomnograph - embla titanium (natus medical incorporated, usa) procedure: plasma cytokines (il-2, il-6 and tnf(tumor necrosis factor)-alfa) procedure: plasma crp(c reactive protein) and leukocytes

Eligibility criteria:
inclusion criteria: * ct-verified diverticulitis patients managed by antibiotic treatment at herlev hospital * pain and fever occurred less than 72 hours prior to the admission * asa (american society of anesthesiologists) score i to iii exclusion criteria: * surgical intervention needed * complicated diverticulitis * complications in relation to diverticulitis * pain and fever occurred more than 72 hours prior to the admission * in anticoagulant treatment and heart rate control treatment * known autoimmune disease * known medically treated sleep-disorder (insomnia, restless legs etc.) and sleep apnea * shift-work or jetlag * daily use of opioid, psychopharmaca, opioids or anxiolytics (including hypnotics) * known psychiatry conditions in treatment with psychopharmaca * daily alcohol intake of more than 5 units or drug abuse * missing written consent * diabetes mellitus * predicted bad compliance * pregnant or breast-feeding * urine or fecal incontinence * severe kidney disease * current cancer
developing a telehealth model to improve treatment access for rural veterans with substance use disorders

Conditions: Substance Use; Substance Use Disorders; Substance Dependence; Veterans

Summary: this project will pilot-test and obtain stakeholder input on a telehealth-delivered substance use disorder (sud) care model (with initial engagement and ongoing mi-cbt treatment) with the goal of increasing treatment utilization and improving outcomes for rural and non-rural veterans with suds.


Eligibility criteria:
inclusion criteria: * veteran patients at the ann arbor va healthcare system * diagnostic and statistical manual of mental disorders (dsm-5) sud diagnosis and/or substance use on average of 2 days a week over the past month * telephone access * able to provide informed consent exclusion criteria: * receiving sud psychotherapy * inability to speak or understand english * substantial mental health instability or conditions that preclude informed consent (e.g., acute psychosis, cognitive deficits) or understanding of assessment or program content * prior alcohol withdrawal seizures or delirium tremens

Keywords: telehealth motivational interviewing cognitive behavioral therapy rural health
effectiveness of inspiratory muscle training with slow breathing in elderly with ish

Conditions: Hypertension

Summary: study the effects of inspiratory muscle training at low load of 25 %maximal inspiratory pressure with slow breathing rate at 6 breaths/min on inspiratory muscle strength, lung function, chest wall expansion, abdominal expansion, exercise capacity and blood pressure in elderly with isolated systolic hypertension.

study the effects of inspiratory muscle training at low load of 25 % maximal inspiratory pressure with slow breathing rate at 6 breaths/min with breathemaxยฎdevice for 8 weeks at home on inspiratory muscle strength, lung function (slow vital capacity, inspiratory capacity), chest wall expansion, abdominal expansion, exercise capacity by arm ergometry and blood pressure in elderly with isolated systolic hypertension. who have age 60-80 years.

Eligibility criteria:
inclusion criteria: 1. subjects aged 60 to 80 years of age with an essential isolated systolic hypertension stage i ii based on recommendation of jnc vii from primary care units in community and the outpatient department of srinakarind hospital in khon kaen province thailand 2. good communication and co operation 3. independent physical activity 4. stable controlled hypertension exclusion criteria: 1. essential isolated systolic hypertension stage iii or secondary hypertension 2. history of heart disease such as coronary artery disease myocardial infarction 3. history of respiratory disease such as asthma chronic bronchitis 4. history of neuromuscular disease such as muscle weakness cerebrovascular disease 5. history of renal disease 6. exercise limited by pain