Kornimate/medical-research-clean huggingface dataset:
examination of exercise adherence i̇n lung cancer patients given calisthenic exercise

Conditions: Exercise Addiction; Lung Cancer

Summary: cancer treatments usually include surgery, chemotherapy, radiation therapy, hormone therapy, and/or a combination of these methods. these treatments cause many physical and psychological effects that interfere with functional independence, performing activities of daily living, and healthy quality of life. mostly, depending on cancer and its treatment; cognitive function, sleep pattern, functional capacity, pain state and bone mineral density are affected. exercise compliance is the degree to which an individual's behavior is consistent with the health care provider's advice and treatment plan. according to the world health organization, compliance is "a measure of a person's behavior (such as following a recommended exercise program, monitoring drug intake, etc.). ) as a response to complying with recommendations deemed appropriate by health care professionals''. in the field of rehabilitation too, compliance is increasingly used in relation to the self-management of patients' health. it has been stated in the studies that the level of compliance with the recommended home exercise is generally low, which limits the benefits of exercise programs.

this study is a cross-sectional study. lung cancer patients who applied to the oncology service and met the inclusion criteria will be included in the study. patients will be randomly assigned to physical activity counseling and education groups. within the scope of the study, exercise compliance will be examined in patients with lung cancer who are given calisthenic exercise. participants will be evaluated before treatment, their functional capacities will be determined, their compliance with exercise, fatigue levels, pain levels, cognitive status, sleep and quality of life will be evaluated with questionnaires. home exercises will be taught to the physical activity counseling group and will be followed up under the supervision of a physiotherapist with weekly controls. breathing exercises and calisthenic exercises will be taught to the training group, and participants will be followed under the supervision of a physiotherapist for 8 weeks, 3 days a week. evaluations will be made before and after the treatment. individuals who do not agree to / give up participating in the study will be able to leave the study voluntarily. all information belonging to individuals will be protected according to the personal data protection law.

Eligibility criteria:
inclusion criteria: * patients whose chemotherapy and radiotherapy has ended, at least 6 months and maximum 5 years after surgery * being between the ages of 18-65 * 3 and 5 years according to the modified borg scale patients with severe fatigue exclusion criteria: * uncontrollable hypertension, diabetes mellitus, heart failure and atrial fibrillation * any acute infection during the evaluation * orthopedic, neurological, psychological, etc., which will limit the evaluations. with problems

Keywords: lung cancer pulmonary rehabilitation calisthenic exercise exercise adherence
robotic hand on hand functions in strokes

Conditions: CVA (Cerebrovascular Accident)

Summary: robotic glove training could be a useful aid for these patients. the aim of this study was to investigate the effect of robotic gloves versus mirror therapy on hand function in patients with cerebral vascular accident .

post stroke patients aged over 40 years were randomly assigned into three groups (a and b ) group . maximum hand grip strength, hand and fugl-meyer assessment-upper extremity (fma-ue), were assessed at baseline, post-intervention, and six-month follow-up.

Eligibility criteria:
inclusion criteria: spasticity level 1 or 1+ according to modified ashworth scale exclusion criteria: uncontrolled seizures hand fractures or surgery

Keywords: stroke hand grip strength
floor sitting study

Conditions: Well-being/Quality of Life; Posture; Sedentary Behaviors

Summary: the goal of this clinical trial is to evaluate the impact of different sitting environments on general well-being and movement patterns in healthy young adults aged 18-35. the main questions it aims to answer are: does floor sitting lead to increased movement and postural changes compared to chair sitting? over a month-long period, how does sustained floor sitting influence overall well-being, posture, and movement habits? researchers will compare the effects of chair sitting and floor sitting in a controlled lab environment (aim 1) and observe the longer-term effects of habitual floor sitting in participants natural environments (aim 2) to see if consistent floor sitting promotes more dynamic movement and comfort. participants will: undergo two 30-minute experimental sitting sessions, one in a chair and the other on the floor, while engaging in typical desk activities (aim 1). participate in a month-long study where they integrate an hour of floor sitting into their daily routines, recording their experiences and any changes in sitting habits through daily diaries and in-depth interview (aim 2).


Eligibility criteria:
inclusion criteria: * age 18-35 years * english-speaking * willing and able to complete study procedures. exclusion criteria: * any injuries or conditions that would limit participants from sitting on the floor in a safe manner, mental states that would preclude the complete understanding of the protocol and compliance, and prior knowledge of the study hypotheses, as it may potentially influence participant behavior and compromise the integrity of the study.

Keywords: sedentary behaviors sitting behaviors ergonomics posture floor sitting accelerometry movement
development and evaluation of the icp waveform tracing capabilities and safety of hs-1000 device

Conditions: Brain Injuries; Intracranial Hypertension

Summary: invasive intracranial pressure (icp) monitoring, using modalities such as parenchymal pressure transducer or external ventricular drain (evd), provides an icp waveform that encapsulates valuable diagnostic and monitoring clinical information. hs-1000 device, a proprietary new non-invasive icp monitor, is expected to display an icp waveform safely and accurately with minimal discomfort to patients, compared to standard invasive icp monitoring procedures used at the participating institutions.

a study will be conducted on 100 patients who undergo invasive icp measurement due to suspected icp elevation, regardless to etiology. each enrolled patient will be monitored with the hs-1000 device and data will be collected throughout the entire procedure. once the data collection is done, results of the non-invasive measurements will be analyzed accordingly. the end-point of the study is to collect at least half an hour of measurements for each participant.

Eligibility criteria:
inclusion criteria: * adult men and women subjects, aged 18 years old and over at screening visit * subjects with neuropathology that the principal investigator considers including in this study. * survival expectancy greater than 72 hours * subject or legal authorized representative (per local regulation) is able and willing to comply with the requirements of the protocol * subject or legal authorized representative (per local regulation) is able to understand and sign written informed consent to participate in the study exclusion criteria: * local ear infection * known allergy or hypersensitivity to any of the test materials or contraindication to test materials * for women of childbearing potential: pregnancy (positive pregnancy test) or breast-feeding * subjects currently enrolled in or less than 30 days post-participation in other investigational device or drug study(s), or receiving other investigational agent(s) * any condition that may jeopardize study participation (e.g., abnormal clinical or laboratory finding) or interpretation of study results, or may impede the ability to obtain informed consent (e.g., mental condition)

Keywords: intracranial pressure noninvasive monitoring
residual exacerbations with mepolizumab

Conditions: Asthma

Summary: this will be a two-year prospective study to characterize the nature of the remaining asthma exacerbations in patients treated with mepolizumab. participants will be assessed every six months from pre- until two years of treatment in addition to whenever they experience an exacerbation of asthma during the study period. during these visits, various clinical, physiological and inflammatory outcomes will be assessed.

before initiation of mepolizumab, a recording of patient's demographics, clinical, physiological and inflammatory features will be recorded. all subjects will be reassessed for the above measures at 6, 12, 18 and 24 months. in addition to the above visits, patients will be assessed every time they experience either moderate or severe exacerbation of asthma over the treatment period. based on the percentage of sputum eosinophils and neutrophils, the type of inflammatory exacerbation will be determined

Eligibility criteria:
inclusion criteria: * with a proven diagnosis of severe asthma as defined by the canadian thoracic society * eligible for mepolizumab treatment * able and willing to sign the informed consent form exclusion criteria: * any respiratory disease apart from asthma * confounding comorbidities sur as eosinophilic granulomatosis with polyangiitis (egpa) or hypereosinophilic syndrome

Keywords: exacerbation inflammation monoclonal antibody
non-invasive measurement of hemoglobin (using pulse co-oximetry) in patients undergoing elective cesarean delivery

Conditions: Postpartum Hemorrhage

Summary: we aim to assess a new pulse oximeter which measures continuous hemoglobin concentration (sphb) in healthy patients undergoing elective cesarean delivery (cs). this patient population often experiences significant blood loss during surgery, and measurements of surgical blood loss are often inaccurate. we will compare measurements of sphb with estimated blood loss during the perioperative period, and laboratory measurements of hemoglobin at set time intervals during the perioperative and postoperative periods (to evaluate the accuracy of this device's ability to measure continuous sphb).

we hope that this pulse oximeter will provide important new information (sphb) about hemoglobin measurement in patients undergoing elective cs, who may often experience significant blood loss and postpartum anemia in the perioperative period. the measurement of perioperative blood loss is often inaccurate, and formal measurements of hemoglobin levels are often associated with time delays, especially in the setting of ongoing acute blood loss. we hope that this device will provide accurate continuous data of hemoglobin in this patient population, which may prove to be a significant advance in patient monitoring in this patient population. probes for sphb measurement will be provided by masimo corporation.

Eligibility criteria:
inclusion criteria: 1. healthy term (\> 37 weeks gestation) 2. asa 1 and 2 pregnant patients undergoing elective uncomplicated cesarean delivery under neuraxial anesthesia 3. age 18-40 yrs exclusion criteria: 1. patients with abnormal hemoglobin disorders. 2. patients with hyperbilirubinemia. 3. patients who are smokers. 4. patients with peripheral vascular disease or conditions affecting vascularity of the digits.

Keywords: cesarean section; hemoglobin; postpartum hemorrhage;
reactor thoracostomy

Conditions: Pneumothorax; Hemothorax

Summary: tube thoracostomy is commonly performed in the emergency department for patients suffering from traumatic hemo- or pneumo-thorax. the procedure involves the use of a scalpel incision at the skin followed by blunt dissection through tissue, penetration into the thoracic cavity, dilation of a tract for tube placement, exploration of the thoracic cavity with a gloved finger, and finally insertion of a sterile tube into the intrathoracic space. the procedure is considered extremely painful despite the routine provision of systemic analgesics and local anesthetics. cadaver and animal studies have demonstrated the use of the reactor chest tube device, a squeeze-activated thoracostomy trochar with placement of a clear sheath for chest tube insertion, to decrease procedure time, incision size, and blood loss. case series and observational reports suggest lower rates of procedural complication and failure as well as increased patient satisfaction due to pain reduction.


Eligibility criteria:
inclusion criteria: 1. subjects age ≥ 18 years old 2. attending physician determination of need for urgent tube thoracostomy for treatment of traumatic pneumothorax, hemothorax, or hemopneumothorax. 3. hemodynamically stable exclusion criteria: 1. pregnant patients 2. prisoners 3. need for emergency thoracostomy 4. hemodynamic instability 5. respiratory distress
infrared imaging in septic illness

Conditions: Sepsis

Summary: the application of infrared thermal imaging in the diagnosis and prognostication of septic illness in adults. during times of severe infection (sepsis), the small blood vessels supplying oxygen and nutrients to the skin and other organs (called the microcirculation), become abnormal and do not function as they normally would in health. monitoring these small blood vessels is difficult to do clinically and the investigators want to investigate a new way of doing this. the aim of this study is to validate a novel method of assessing the function of the microcirculation in healthy volunteers and patients with sepsis, by measuring the skin temperature profile of the leg and face with a thermal imaging camera. thermal imaging cameras measure the heat given off by all objects and represents this as a picture, with colour used to represent the different temperatures. patients will be recruited from the emergency department and intensive care units at university hospitals of leicester in to one of two groups based on their illness severity; uncomplicated sepsis and severe sepsis. healthy volunteers will be recruited in to a third group. recruitment will take place over a 6-month period with follow-up lasting for 12-months following recruitment. 105 participants will be recruited in total. temperature patterns seen on the face and leg will be investigated between the different groups. changes in these temperature patterns as patients recover from sepsis (or indeed become worse), will also be investigated. information from the thermal images will be correlated to routinely measured markers of infection, including clinical measurements (blood pressure, pulse, etc) and routine blood investigations.


Eligibility criteria:
inclusion criteria: 1. male or female, aged 18 years or above. 2. healthy volunteers - free from acute illness; will include staff and students at the university of leicester and uhl, and patient relatives. 3. patient with septic illness will be recruited in to one of two groups depending on their disease severity - sepsis (without evidence of organ dysfunction) or severe sepsis (with organ dysfunction). 4. able (in the investigators opinion) and willing to comply with all study requirements. exclusion criteria: 1. patient refusal 2. inability to gain appropriate assent/consent 3. children 4. prisoners or in police custody 5. skin marking likely to preclude image analysis (such as extensive tattoos).

Keywords: microcirculation thermal temperature
permanent cerebral oxymetry monitoring for early diagnosis and treatment of delayed vasospasm after subarachnoid hemorrhage

Conditions: Subarachnoid Hemorrhage

Summary: transcranial doppler ultrasound (tcd) monitoring and ct-scanner perfusion are useful but imperfect tools to identify vasospasm and allow intervention to avoid infarction. permanent monitoring of cerebral tissue oximetry (rso2) by nirs, a noninvasive method could allow better vasospasm detection. this study will evaluate diagnostic accuracy of cerebral oxymetry (nirs) -by rso2 measurement - in order to detect vasospasm in patient with severe subarachnoid hemorrhage compare to standard monitoring tools.

delayed vasospasm is a serious complication of aneurismal subarachnoid haemorhage (sah) significantly influencing morbidity and mortality. mostly observed between days 4 and 10 after aneurismal rupture, its incidence is higher in cases of severe sah. vasospasm strongly affects prognisis generating delayed cerebral ischemia. clinical deterioration (focal neurological deficit) is the best way to detect severe vasospasm. unfortunately, most of severe sah are intubated and sedated prohibiting neurological evaluation. in these frequent situations, transcranial doppler (tcd), clinical and biological monitoring, ct-scanner (angio-ct and perfusion-ct), mri and cerebral angiography are routinely used to detect vasospasm. yet, these tools have imperfect sensitivity and specificty delaying diagnosis and treatment. near-infrared spectroscopy (nirs) is a non-invasive method measuring tissue oxygenation by regional saturation of capillary-oxygenated hemoglobin (rso2). this technology demonstrated ability to measure cerebral oxygenation and has previously been reported to monitor carotid and pediatric surgery. to date a few studies also reported nirs monitoring feasability in post-sah vasospasm. our aim is here to evaluate nirs monitoring for the diagnosis of vasospasm in severe sah.

Eligibility criteria:
inclusion criteria: * men and women * age ≥ 18 years * hsa of aneurysmal etiology less than 4 days before inclusion diagnosed by clinical presentation and emergency imaging * hsa "severe" defined according to the wfns ≥ iii * intubated-ventilated patient or any other reason preventing a contributing neurological examination * affiliate or beneficiary of a social security scheme * free, informed and written consent signed by the representative exclusion criteria: * age \<18 years * significant vasospasm as soon as the detection was detected on the initial imaging * possible neurological surveillance * intra-parenchymal frontal haematoma limiting the quality of measurement, diagnosed on imaging (less than 25mm deep from the skin) * patient in limitation of active therapeutics or with high probability of soon limitation of active therapeutics * adhesive allergy to measuring patches * patient under guardianship or safeguard of justice * refusal of legal representative

Keywords: intracranial oxymetry subarachnoid hemorrhage vasospasm
ultrasound to assess sarcopenia in prader willi syndrome

Conditions: Prader-Willi Syndrome; Sarcopenia; Metabolic Syndrome

Summary: the aim of the study is to examine the clinical applicability of ultrasound as a diagnostic tool for sarcopenia in individuals with pws by investigating the association between ultrasound-derived measurements, dxa-derived measurements, and sarcopenia-related outcomes.

sarcopenia is an age-related loss of muscle mass plus low muscle strength, and/or low physical performance, that may affect over 25% of individuals over the age of 60, resulting in an increased likelihood of developing disability. abnormal body composition with an increased in body fat mass and a decreased in skeletal muscle mass were noted in individuals with prader willi syndrome (pws), thought to be related to hormonal deficiencies due to hypothalamic dysfunction, presenting as a unique congenital model of sarcopenia. muscle mass can be measured by dual-energy x-ray absorptiometry (dxa) scan device, but it is expensive, increased radiation exposure, and not easily accessible in all clinical practice. ultrasound (usd) is a non-invasive, without ionising radiation, low-cost, and easily accessible tool for the assessment of soft tissue. there were increasing evidence for the use of usd in the measurement of muscle thickness (mt), cross-sectional area (csa) and pennate anle (pa) of different muscle groups in different populations. however, the use of usd as a routine diagnostic tool in individuals with pws has not been reported yet. the aim of the study is to examine the clinical applicability of ultrasound as a diagnostic tool for sarcopenia in individuals with pws by investigating the association between ultrasound-derived measurements, dxa-derived measurements, and sarcopenia-related outcomes.

Eligibility criteria:
inclusion criteria: * genetically diagnosed individuals with pws who can cooperate with the examinations exclusion criteria: * individuals with pws who have arthritis, fractures, or severe musculoskeletal deformities that could interfere with the examinations. * individuals with pws who have severe cognitive impairment and are unable to read or sign the written consent.

Keywords: prader-willi syndrome sarcopenia ultrasound skeletal muscle body composition
effect of intraoperative dynamic compliance guided individualized positive end-expiratory pressure on postoperative atelectasis after laparoscopic bariatric surgery

Conditions: Postoperative Atelectasis

Summary: this study intends to explore the effect of dynamic compliance guided individualized positive end-expiratory pressure titration strategy on reducing the level of postoperative atelectasis in obese patient who have laparoscopic bariatric surgery.the results of the study are to assess the effects of this intervention on the incidence，duration of postoperative atelectasis and other complications including hypoxemia etc. after laparoscopic bariatric surgery.and reducing the burden of postoperative atelectasis on patients and their families, hospitals and public resources.


Eligibility criteria:
inclusion criteria: 1. bmi ≥ 35 kg/ m2 2. over 18 years old 3. elective laparoscopic bariatric surgery (gastric bypass or sleeve) exclusion criteria: 1. asa \>iv 2. lung bullae 3. thoracic surgery history 4. quit smoking less than 1 week 5. chronic obstructive pulmonary disease requiring oxygen 6. congestive heart failure (new york heart association classification ≥ iii) 7. planned to be transferred to intensive care unit after surgery 8. patients participating in another interventional study 9. refuse to sign the informed consent

Keywords: lung protective ventilation strategy individualized positive end-expiratory pressure laparoscopic bariatric surgery mechanical ventilation anesthetic management lung dynamic compliance postoperative atelectasis
a retrospective swedish cohort study on health outcomes, life expectancy, resource use and costs in patients with a history of myocardial infarction and additional risk factors for atherothrombosis

Conditions: Acute Coronary Syndrome

Summary: to characterize and estimate the size of different populations with a history of acute coronary syndrome in sweden. to assess the burden of illness (co-morbidities, mortality rates healthcare resource utilization and atherothrombotic events) among patients with a history of myocardial infarction (mi) 1-3 years ago and additional risk factors for atherothrombosis.


Eligibility criteria:
inclusion criteria: - patients hospitalised for acs between 01.07.2006 and 31.06.2011. exclusion criteria: - not applicable

Keywords: acute coronary syndrome myocardial infarction retrospective cohort study healthcare resources utilization
rct - does treating incompetent perforators reduce recurrence?

Conditions: Varicose Veins

Summary: the aim of this randomised case-controlled trial is to investigate whether ablation of incompetent perforating vein in addition to ablation of truncal vein reduces the rate of recurrent varicose veins post-treatment compared with patients who only have ablation of the truncal vein, who are left with untreated incompetent perforating veins.


Eligibility criteria:
inclusion criteria: * primary varicose veins caused by great saphenous vein reflux * at least one incompetent perforating vein refluxing into the varicosities * over 18 years of age exclusion criteria: * reflux from pelvic vein origin or small saphenous vein * previous varicose vein surgery, * incompetent perforators remote from the varicosities treated, * deep vein incompetence * deep vein obstruction or occlusion

Keywords: incompetent perforating veins evla phlebectomies transluminal occlusion of perforators (trlop) closure of incompetent perforators.