Kornimate/medical-research-clean huggingface dataset:
reveal linq™ in-office 2 (rio2) study international

Conditions: Arrhythmia

Summary: the purpose of the rio 2 international study is to provide clinical and economic evidence to support moving the linq™ insertion procedure outside these traditional locations within the hospital, referred to as "out-of-cathlab".

the traditional location of the linq™ insertion procedure is the catheterization laboratory, electrophysiology laboratory, or operating room. the purpose of the rio 2 international study is to provide clinical and economic evidence to support moving the linq™ insertion procedure outside these traditional locations within the hospital, referred to as "out-of-cathlab".

Eligibility criteria:
inclusion criteria: * patient is indicated for continuous arrhythmia monitoring with a reveal linq™ insertable cardiac monitor (icm) * patient is at least 18 years of age or older if required by local regulations * patient is willing to undergo icm insertion procedure outside of the cathlab, operating room, or ep lab setting with only local anesthetic * patient is willing and able to provide consent and authorize the use and disclosure of health information * patient is willing and able to comply with the elements of the clinical investigation plan including the required follow-up exclusion criteria: * patient has unusual thoracic anatomy or scarring at the insertion site which may adversely affect the success of the insertion procedure * patient has reduced immune function or is otherwise at high risk for infection per physician discretion * current therapy with immunosuppressive agents or chronic steroid use e.g. prednisone greater than 20mg per day * patient requires hemodialysis * patient with active malignancy or history of chemotherapy or radiation treatment * patient has had a recent (within 30 days) or an active infection including but not limited to pneumonia, urinary tract, cellulitis, or bacteremia * patient has had major surgery (in the past 6 months) patient has undergone a procedure which required central venous or intra-arterial access (e.g. af/vt ablation, ep study, coronary angiography) within the last 3 months or is scheduled for such a procedure while enrolled in the study * prior history of surgical infection, prosthetic device infection, or endovascular infection, including endocarditis, in the past 12 months * patient has a central venous port, an atrio-venous fistula, or a prosthetic valve * patient requires conscious or moderate sedation to receive linq™ * patient already has an inserted or implanted loop recorder * patient is implanted or indicated for implant with a pacemaker, icd, crt device * patient is enrolled in another study that could confound the results of this study, without documented pre-approval from a medtronic study manager * patient's life expectancy is less than 6 months * patient is legally incapable of giving consent * patient is pregnant\* \*note: possible pregnancy will be assessed by the physician asking the patient; a pregnancy test is not required
examining strategy monitoring and remediation training

Conditions: Psychotic Disorders; Executive Dysfunction

Summary: executive function training is a cognitive training approach that specifically trains executive functioning for people with schizophrenia-spectrum disorders. the current study compares full executive function training to computerized training alone and to strategy monitoring alone.

all interventions will involve 4 weeks of group treatment consisting of two 1-hour group sessions per week and additional practice at home between sessions. the executive training condition will consist of 50% of the session practicing computerized cognitive training exercises, and 50% of the session developing cognitive strategies to use in the computerized exercises. participants are encouraged to complete 40 minutes of computerized training per day, and complete strategy worksheets, at home between sessions. in computerized cognitive training only participants will spend the entire one-hour session practicing computerized training exercises. between sessions participants will be encouraged to practice the computerized exercises at home for 40 minutes per day. there will be no strategy development in this condition. in strategy development only participants will engage in cognitive strategy discussions to develop new executive function strategies that can be used in daily life. between sessions, participants will be encouraged to practice their cognitive strategies in their daily life and track their strategies using the strategy worksheet. there will be no computerized cognitive training in this condition. all interventions will be delivered virtually in the participant's home and group sessions will be conducted using the online platform zoom. 90 participants with schizophrenia-spectrum disorders will be recruited. power analyses, conducted with gpower, indicate that 90 participants (30 per treatment condition), accounting for an upper limit of 25% attrition observed in my previous trials of et, provides 80% power to detect a medium effect size (cohen's f = 0.2) difference between conditions. primary and secondary outcomes will be examined using linear mixed models on the intent-to-treat sample with missing data interpolated using maximum likelihood estimation. the primary endpoint is the 3-month follow-up assessment, and secondary endpoint of post-treatment will also be examined.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia, schizoaffective disorder or any other psychotic disorder (based on dsm-v) * 18-65 years of age * know how to use a computer * not abusing drugs or alcohol * can read and speak english. exclusion criteria: * enrolled in a cognitive training program in the last 6 months * neurological disease or neurological damage * medical illnesses that can change neurocognitive function * medical history of head injury with loss of consciousness * physical handicaps

Keywords: psychosis schizophrenia cognitive remediation executive functioning strategy monitoring computerized practice cognitive training
the effect of diclofenac potassium insitu gel vs calcium hydroxide as intra-canal medications on post-operative pain and anti-bacterial effect

Conditions: Post Operative Pain

Summary: the aim of this study is to clinically compare the post-operative pain level and antibacterial effect when using the diclofenac potassium insitu gel versus calcium hydroxide as an intra- canal medication in patients with apical periodontitis.


Eligibility criteria:
inclusion criteria: * age between 18-45 years old. * males/females. * lower permanent premolars with: non-vital pulps. sensitive to percussion. negative response to cold pulp tester (ethyl chloride spray1). apical periodontitis * systemically healthy patients (asa i or ii). exclusion criteria: * medically compromised patients having significant systemic disorders. (asa iii or iv). * history of intolerance to nsaids. * patients with two or more adjacent teeth requiring endodontic treatment. * teeth with : * association with swelling or fistulous tract. * acute or chronic peri-apical abscess. mobility grade ii or iii. * pocket depth more than 5mm. * previous root canal therapy. * non-restorability * patients with a contraindication for the use of dfk or those known to be allergic to any of the study medications.eg. patient with kidney problems.

Keywords: calcium hydroxide diclofenac potassium intra-canal medications
efficacy of ablative fractional laser-assisted photodynamic therapy according to the laser density for actinic keratosis

Conditions: Actinic Keratosis

Summary: erbium:yttrium aluminum garnet (er:yag) ablative fractional laser-assisted photodynamic therapy (afl-pdt) has shown significant benefit for the treatment of actinic keratosis(ak). er:yag ablative fractional laser ablates the epidermis and dermis without significant thermal injury, creating microscopic ablation zones (maz) in the portion of the skin that the laser is applied to. the formed maz depends on the laser parameters such as laser depth, laser density and laser passes, which affect the treatment outcome.

this study evaluated whether different laser densities influenced the efficacy, side effects, cosmetic outcomes, and protoporphyrin ix (ppix) accumulation of afl-pdt for facial ak in a randomized clinical trial.

Eligibility criteria:
inclusion criteria: * korean patients aged ≥ 18 years who had biopsy-confirmed actinic keratosis lesions exclusion criteria: * photosensitivity disorder patients * lactating or pregnant women * patients with porphyria or a known allergy to any of the constituents of the mal cream and lidocaine * patients with systemic disease, history of malignant melanoma, tendency of melasma development or keloid formation, any ak treatment of the area in the previous 4 weeks, or any conditions associated with a risk of poor protocol compliance; and patients on immunosuppressive treatment

Keywords: actinic keratosis ablative fractional laser photodynamic therapy ablative density protoporphyrin ix
proton re-irradiation for recurrent head and neck cancer

Conditions: Head and Neck Cancer

Summary: the purpose of this study is to evaluate the tumor control and the side effects of using proton therapy for head and neck cancer that has come back.


Eligibility criteria:
inclusion criteria: * patient willing and able to provide written informed consent * age ≥18 years at the time of consent * pathologically confirmed diagnosis of a recurrent or a new primary head and neck cancer * a history of prior radiation to the head and neck (\>/= 40 gy, in 2 gy/fraction equivalent) * the recurrent or the second primary tumor is unresectable, the patient elects against surgical resection; patients who underwent surgery who has indications for postoperative radiation therapy is also eligible * men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months after treatment note: patient with \ 6 months of life expectancy will be treated with conventionally fractionated full dose re-irradiation approach. additional other factors determining which patients will be treated with quad shot therapy rather than full dose are if the patients have poor performance status, bulky or diffuse disease, significant medical co-morbidities, and significant metastatic disease burden. exclusion criteria: * women who are pregnant or lactating * inability to comply with study and/or follow-up procedures * \<6 months between completion of prior rt and initiation of reirradiation using proton therapy

Keywords: proton re-irradiation 17-300
postoperative complication after free flap reconstruction for head and neck cancer

Conditions: Head and Neck Cancer; Recurrent Cancer; Surgery--Complications

Summary: this study was designed to investigate the outcome of free-flap reconstruction surgery following head and neck cancer resection between primary and recurrent head and neck cancer patients.


Eligibility criteria:
inclusion criteria: * patients with head and neck cancer who underwent tumor wide excision and primary free flap reconstruction or secondary free flap reconstruction between march 2008 and february 2017 * age: 20\~100 years old exclusion criteria: * patients with missing or unvalidated data * patients less than 20 years old
a safety, pharmacokinetics and pharmacodynamics study of ro6811135 in patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus Type 2

Summary: this randomized, double-blind, placebo-controlled, multiple ascending dose study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ro6811135 in patients with type 2 diabetes mellitus. patients will be randomized to receive either ro6811135 or placebo daily for 2 weeks, with a follow-up examination 2 to 3 weeks after the last dose of study drug.


Eligibility criteria:
inclusion criteria: * adult patients, 18 to 65 years of age, inclusive * type 2 diabetes mellitus according to who criteria diagnosed for at least 3 months prior to screening * on stable dose of metformin for at least 2 months prior to screening * fasting plasma glucose during the screening period \</= 240 mg/dl * hemoglobin a1c (hba1c) levels at screening \>/= 6.5% and \</= 10.5% * evidence of insulin secretory capacity at screening * body mass index (bmi) 27 to 42 kg/m2, inclusive * females of child-bearing potential and males with female partners of child-bearing potential must agree to use effective contraception as defined by protocol exclusion criteria: * type 1 diabetes * acquired or secondary forms of diabetes such as those resulting from pancreatic surgery/injury, cystic fibrosis related diabetes * history of acute metabolic complications such as diabetic ketoacidosis or state of hyperosmolar hyperglycemia * evidence or history of clinically significant diabetic complications such as clinically severe diabetic peripheral neuropathy, clinically significant nephropathy as judged by the investigator, or pre-proliferative/proliferative diabetic retinopathy as judged by the investigator * history of severe symptomatic hypoglycemia (requiring assistances of a third party) within 6 months prior to screening * history or presence of clinically significant concomitant disease or disorder * hemoglobin level below the lower limit of reference range at screening * pregnant or lactating women * history of anaphylaxis or severe systemic hypersensitivity or allergic reactions
semantic recognition task (srt) in alzheimer disease

Conditions: Alzheimer Disease

Summary: the goal of this study is to observe the outcomes of a semantic recognition task in alzheimer disease and discuss what this might add to clinical practice.

in classical memory testing procedures, the outcomes of recognition task is related to hippocampal memory deficits knowing that the recognition task is not purely temporal lobe activity. the aim of this study is to propose a recognition task more specific to temporal lobe activity.

Eligibility criteria:
inclusion criteria: * to have biomarker analysis for alzheimer disease (positive or negative). exclusion criteria: * illiteracy

Keywords: alzheimer disease recognition semantic memory free and cued selective reminding test
effects of modified pilates on improving trunk control and balance in children with mild intellectual disability

Conditions: Mild Intellectual Disability

Summary: this randomized controlled trial will be conducted at spectrum clinic, lahore, over a duration of 8 weeks to assess the impact of modified pilates exercises on trunk control in children with intellectual disability (id). id is characterized by below-average iq and delays in cognitive and functional development, affecting independence and motor skills. trunk control plays a crucial role in posture, movement coordination, balance, and daily activities. a total of 40 participants will be selected through non-probability convenience sampling and randomly assigned to two groups: group a (modified pilates exercises) and group b (general physiotherapy plan). outcomes will be measured using the trunk control measurement scale (tcms) and pediatric balance scale (pbs) at baseline and after 8 weeks. data will be analyzed using spss version 25.

intellectual disability (id) is a condition in which individuals experience below-average iq. although a variety of terms, including learning disabilities and mental retardation have been used when referring to people who have impairments that impact on their cognitive and adaptive functioning. id refers to the onset of delayed developmental milestones, which impact on intellectual and functional development, hence independent functioning is likely to be significantly lower than that of the average person during their lifetime. trunk control can help children with intellectual disabilities meet developmental milestones by helping them to maintain posture, navigate their surroundings, coordinate body part movement, module fine motor control, initiate vestibule oculomotor reflexes, use their hands for various activities, remain seated without falling over and kept their body aligned while walking, running and jumping. this study will be randomized controlled trial, conducted in spectrum clinic, lahore. this study will be completed in time duration of 8 weeks after the approval of synopsis. non-probability convenience sampling technique will be used and 40 participants will be recruited in this study. participants will be divided into two groups. group a (modified pilates exercises) and group b (general physiotherapy plan). tools will be used are trunk control measurement (tcms) and pediatric balance scale (pbs). the data will be recorded at the baseline and after 8th week of intervention. after collection, data will be analyzed by using spss version 25.

Eligibility criteria:
inclusion criteria: * children aged 6-12 years. * diagnosed with mild intellectual disability (iq 50-70) * ability to follow instruction and participate in pilates exercises * no significant physical or neurological conditions that could affect participants exclusion criteria: * severe intellectual disability(iq\<50) * significant physical and neurological conditions (cerebral palsy, spinal cord injury) * visual and hearing impairments that could impact participation

Keywords: mild intellectual disability trunk control balance physical therapy pilate exercises
exercise efficacy on autism spectrum disorder

Conditions: Autism Spectrum Disorder (ASD)

Summary: the goal of this clinical trial is to learn if regular exercise intervention may improve the health status of the participants diagnosed with autism spectrum disorder, ages between 5-13 years old. the main question it aims to answer is: * if combined regular exercise program improves motor skills, repetitive movements, aerobic capacity and quality of life of participants? * researchers will compare the exercising and non-exercising participants to see if regular exercise improves the health related parameters. participants will do exercise for 12 weeks regularly.

before and after the exercise program; * the parents of the participants will fill out the abc problem behaviour control scale * the participants will perform 6 minute walk test, sit-reach flexibility test, grip strength test. body fat analysis will be performed by using bioimpedance analysis method. * participants will also perform mobak-1 test which measures motor competencies exercise program include; 10 minutestreadmill walk, playdough or ball squeeze, towel wring,throwing to target, catching the tennis ball, bouncing a ball inside borders without losing control, dribbling a ball inside borders without losing control, tandem walk, single leg stance balance on balance pad or pillow, rolling forward, jumping exercises, side stepping, etc. the implementation of exercise programs, the follow-up process, and data recording methods will be documented and applied by the research team. data will be analyzed in the spss 28 statistical package program. the data distribution will be checked by kolmogorov smirnov and the homogeneity of variances by the levene test. for variables with normal distribution, one-way anova will be used for multiple comparisons, and an independent t-test will be used for pairwise comparisons. wilcoxon test will be used for pairwise comparisons in dependent variables that do not fit a normal distribution, and the mann- whitney u test will be used in independent variables. the relationship between continuous variables will be tested using the correlation coefficient, and the relationship between categorical variables will be tested using the chi-square test. descriptive statistics will be given as mean ± standard deviation. results will be considered statistically significant for p\<0.05.

Eligibility criteria:
inclusion criteria: children with autism spectrum disorder - exclusion criteria: * children who are unable to adapt exercise programs

Keywords: autism exercise mobak-1 6-min walk test
mobile app in addiction

Conditions: Addiction

Summary: the sleep and behavior agendas are today very largely underused while they can be of a considerable contribution in the follow-up of the patients and the reinforcement of the therapeutic alliance. in the management of addictions, sleep disorders are a major comorbidity, these two components maintain indeed complex links: it was highlighted a bidirectional relationship between the effect of the consumption of addictive substances on sleep and conversely, the effect of sleep disorders on the consumption of products, the same is true for overexposure to screens.

the sleep and behavior agendas are today very largely underused while they can be of a considerable contribution in the follow-up of the patients and the reinforcement of the therapeutic alliance. in the management of addictions, sleep disorders are a major comorbidity, these two components maintain indeed complex links: it was highlighted a bidirectional relationship between the effect of the consumption of addictive substances on sleep and conversely, the effect of sleep disorders on the consumption of products, the same is true for overexposure to screens.

Eligibility criteria:
inclusion criteria: * teenagers or young adults from 12 to 18 years old (included) * consultant for addiction to cannabis and / or tobacco and / or alcohol and / or screen * treated within the functional unit of addictology * for minors, after parental consent exclusion criteria: -

Keywords: mobile app, pilot study, addiction, sleep, epro
vitamin d and periodontitis

Conditions: Alveolar Bone Loss

Summary: vitamin d has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. our aim was to investigate the relation between serum 25-hydroxy vitamin d levels, clinical periodontal parameters and blood serum biomarkers. the subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin d (25-oh vit d), osteoprotegerin (opg), receptor activator of nuclear kappa b ligand (rankl), c-telopeptide (ctx), tumor necrosis factor-α (tnf-α)).


Eligibility criteria:
* inclusion criteria: * never-smokers * no history of systemic disease * no patients had been under periodontal therapy and medicine for at least 6 months before the study * no pregnancy or lactation * no alcohol or antioxidant vitamin consumption. * exclusion criteria: * -

Keywords: 25-oh vitamin d rankl osteoprotogerin tnf-α
severe cutaneous adverse reactions in thailand

Conditions: Steven-Johnson Syndrome; Toxic Epidermal Necrolysis; Drug Reaction With Eosinophilia and Systemic Symptoms; Acute Generalized Exanthematous Pustulosis; Generalized Bullous Fixed Drug Eruption

Summary: the multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in vitro drug allergy diagnosis for the confirmation of the causative drugs

patients with severe cutaneous adverse reactions (steven-johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, and generalized bullous fixed drug eruption) among six tertiary medical institutes in thailand will be recruited to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of using laboratory techniques for the confirmation of the causative drugs

Eligibility criteria:
inclusion criteria: * patients fulfilled criteria of probable or definite cases of sjs, ten, dress, or agep according to regiscar validation criteria as well as patients diagnosed with gbfde exclusion criteria: * patients later confirmed to have other diagnosis than diseases mentioned above or have no sufficient data for the registry

Keywords: drug allergy drug hypersensitivity adverse drug reactions severe cutaneous adverse reactions