Kornimate/medical-research-clean huggingface dataset:
vitamin d levels in neonatal umbilical cord blood: factors and prognostic analysis

Conditions: Vitamin d Deficiency

Summary: this study is a retrospective-prospective cohort study that investigates the factors influencing neonatal umbilical cord blood 25(oh)d levels, and the impact of exposure to low intrauterine 25(oh)d levels on neonatal prognosis. newborns born in sun yat-sen memorial hospital of sun yat-sen university from august 2023 to august 2024 were selected. 2ml of umbilical cord blood was collected to test serum 25(oh)d levels. based on the umbilical cord blood 25(oh)d levels, newborns were divided into three groups: vitamin d deficiency (\ 50\~250nmol/l). factors influencing neonatal vitamin d levels at birth were investigated by reviewing medical records, questionnaire collection, phone interviews, etc., collecting data on basic neonatal information, maternal information, complications during pregnancy, prenatal biochemical test results, medication history during pregnancy, lifestyle habits during pregnancy, and vitamin d supplementation status. phone follow-ups on the health of the newborns during their hospital stay and at 1 month and 2 months after discharge were conducted to investigate the impact of exposure to low intrauterine 25(oh)d levels on neonatal prognosis, providing a theoretical basis for early intervention in high-risk pregnant women and early identification of high-risk groups with vitamin d deficiency or insufficiency among newborns. miscarriages prevention is a major feature of our hospital's obstetrics department. many pregnant women who are hospitalized and give birth at our hospital have a history of fetus protection. choosing pregnant women and newborns from our hospital's obstetrics department as research subjects is conducive to exploring the impact of specific diseases and medication histories on neonatal vitamin d deficiency, which is an innovative aspect of this study.


Eligibility criteria:
inclusion criteria: * newborns delivered in sun yat-sen memorial hospital's obstetrics department. * relatives agree to use clinically discarded specimens for research and have signed a consent form. exclusion criteria: * newborns with genetic mutations or congenital malformations. * patients who died before discharge. * pregnant women with conditions like chylous diarrhea, inflammatory bowel disease, and other chronic digestive system diseases.

Keywords: vitamin d neonatal umbilical cord blood influence factors prognosis
the safety and efficacy of methylene blue mmx® modified release tablets administered to subjects undergoing screening or surveillance colonoscopy

Conditions: Colorectal Cancer

Summary: evaluation of the histologically proven adenoma and carcinoma detection rate in patients undergoing a full colonoscopy with and without mucosal contrast enhancement, obtained with 200 mg of methylene blue mmx® tablets.


Eligibility criteria:
inclusion criteria: * males or females, aged between 50 and 75. * outpatients scheduled for screening or surveillance colonoscopy for polyps or colorectal cancer ) * able to comprehend the full nature and purpose of the study, including possible risks and side effects. * able to co-operate with the investigator and to comply with the requirements of the entire study. * signed written informed consent prior to inclusion in the study. exclusion criteria: * patients at high risk of colorectal cancer e.g. ulcerative colitis * previous medical history of, or suspected hypersensitivity to, the methylene blue and/or formulations' ingredients. * previous medical history of, or suspected hypersensitivity to, the peg based bowel cleansing preparation and/or bowel cleansing formulations' ingredients. * previous medical history of gastrointestinal obstruction or perforation, toxic megacolon, major colonic resection, severe diverticulitis, heart failure (class iii or iv), serious cardiovascular disease, ulcerative colitis or crohn's disease.
a comparison of the effect of carvedilol and metoprolol on airways tone in patients with heart failure

Conditions: Heart Failure; Chronic Obstructive Airway Disease

Summary: this study looks at the effect of two drugs (carvedilol and metoprolol) which are used for patients with chf (chronic heart failure). these agents are beta-blockers and, although effective in heart failure, may cause increases in airways tone and thus limit air getting into the lower parts of the lungs. carvedilol is more active at blocking the receptor that opens up the airways and therefore theoretically may be more likely to reduce airways tone than metoprolol, although this has never been studied in patients with heart failure, and that is the purpose of the present study. we are looking to enrol 45 patients with heart failure and mild obstruction to the flow of air in their lungs. patients will be randomised to either carvedilol or metoprolol (standard doses). following a minimum of 2 weeks of therapy of study medication the patient will undergo a study day involving an assessment of their lung function, an assessment of their heart failure, a "living with heart failure" questionnaire, blood tests and blood pressure and heart rate readings. patients will then be crossed over to the alternate medication. following 2 weeks on the target dose the patient will undergo their second study day which will be the same as the first. the results obtained from each study day will be compared.


Eligibility criteria:
inclusion criteria: * males and females over 18 years of age * documented chf (nyha class ii-iv symptoms) * airflow obstruction defined as patients with symptomatic obstructive respiratory disease as manifest by any of the following symptoms of wheeze, primarily attributed to airflow obstruction requirement for intermittent or regular bronchodilator therapy fev1 less than 70% predicted pre-salbutamol * confirmed written informed consent. * clinically indicated to receive β-blockade. * no evidence of heart block on ecg. * patients will be in one of the following categories: currently on carvedilol currently on toprol-xl or metoprolol tartrate currently on bisoprolol clinically indicated to receive β adrenoceptor blockade but not currently prescribed a β-blocker. exclusion criteria: * women lactating, pregnant or of childbearing potential not using a reliable contraceptive method. * patients who had received an investigational new drug within the last 4 weeks. * patients with a history of a psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study. * laboratory parameters: creatinine \>0.30 mmol/l liver function tests 3x uln * recent (\<12 months) myocarditis
the acetylcysteine for contrast-induced nephropathy trial

Conditions: Acute Kidney Failure

Summary: the purpose of this study is to evaluate the efficacy of acetylcysteine compared to placebo for the contrast-induced nephropathy prevention, between 48 and 96 hours after procedures that use contrast. contrast-induced nephropathy is defined as an increase of 25% in serum creatinine before the procedure.


Eligibility criteria:
inclusion criteria: at least one of the following criteria: * aged more than 70 years-old * chronic renal failure (defined as serum creatinine higher than 1.5mg/dl within the last 3 months) * diabetes mellitus * congestive heart failure or ventricular disfunction (left ventricular ejection fraction less than 0.45) * shock or intra-aortic balloon pump use * urgency or emergency procedures exclusion criteria: * pregnant women, breastfeeding or aged below 45 years-old and with no efficacious contraceptive methods. * patients in dialysis * previous inclusion in this trial * patient refusal to informed consent * pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento s-t nos quais não seja possível administrar o protocolo de hidratação pré e pós-procedimento.

Keywords: acetylcysteine contrast-induced nephropathy angiography angioplasty with or without stent
comparison of butorphanol and tramadol associated patient-controlled analgesia (pca) after hysterectomy

Conditions: Postoperative Pain; Hysterectomy

Summary: intravenous patient-controlled analgesia (pca) is a popular technique for postoperative pain management. although several drugs are recognized as effective therapeutic options, optimal selection of drugs in hysterectomy patients underwent different anesthesia treatments remains unknown explicitly. the investigators hypothesized that butorphanol and tramadol can produce different analgesic effects with intravenous pca after abdominal hysterectomy.


Eligibility criteria:
inclusion criteria: * asa physical status i-ii * chinese * 19-64yr * uterus myoma exclusion criteria: * allergy to opioids, a history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records. * participants younger than 18yr，older than 65yr or pregnancy was eliminated. * due to the significant changes in vital signs might affect cognition of pain and that of sensation, over 20% variation of these records from the baselines or below 92% of spo2 under 20-40% nasal tube oxygen at any time should be excluded from the study. * those who were not willing to or could not finish the whole study at any time. * any patient who exhibited a combative or incoherent state of pca analgesia would be excluded from the study. * allergy to local anesthetics. * failed to perform the epidural catheterization. * those who demonstrated significant nerve-associated side effects from the insertion of the epidural needle.

Keywords: pain, postoperative analgesics, opioid analgesia, patient-controlled pain measurement
neurally adjusted ventilatory assist for non invasive ventilation and patient-ventilator interaction

Conditions: Non Invasive Ventilation; Patient Ventilator Interaction

Summary: the present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (ps) and neurally adjusted ventilatory assist (nava) in a group of patients receiving non invasive ventilation (niv)for an episode of acute respiratory failure of various origin.

the present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (ps) and neurally adjusted ventilatory assist (nava) in a group of patients receiving non invasive ventilation (niv)for an episode of acute respiratory failure of various origin. the subgroup of copd patients will be analyzed separately. the effects of various setting of neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Eligibility criteria:
inclusion criteria: * patients admitted to the icu and treated with non invasive ventilation for acute respiratory failure of any origin exclusion criteria: * severe hypoxemia requiring an fio2\>0.6 * hemodynamic instability * known oesophageal problem * active upper gastro-intestinal bleeding * any other contraindication to the insertion of a naso-gastric tube * impaired consciousness or absence of patient cooperation * facial or laryngeal lesions contraindicating the use of niv * poor short term prognosis

Keywords: mechanical ventilation non invasive ventilation patient-ventilator interaction pressure support neurally adjusted ventilatory assist
the impact and effect of traditional chinese medicine treatment on organ failure in critically ill patients

Conditions: Organ Failure, Multiple; Indigestion; Delayed Gastric Emptying; Respiratory Failure; Morality

Summary: critically ill patients are at risk of or suffering from one or more key organs or organ system failure. this study will measure the effect of traditional chinese medicine(tcm) interventions on critically ill patients admitted to the intensive care unit (icu). the goal of this clinical trial is to learn if traditional chinese medicine(tcm) is effective for prevention and treatment of organ failure in icu patients. patients in this group will receive intervention for 2 weeks. a multi-center non-randomized real word data study, will include 3 groups: intervention group (tcm)(n=70), control group and historical control group (admitted to the same icu in the period of 01.2019 to 12.2023). main outcomes include sequential organ failure assessment (sofa) score, icu length of stay, hospital length of stay, number of days of respirator uses and western medicine medication used study follow up will be 2 weeks.

critically ill patients are at risk of or suffering from one or more key organs or organ system failure. this study will measure the effect of traditional chinese medicine(tcm) interventions on critically ill patients admitted to the intensive care unit (icu). a multi center non-randomized real word data study, will include 3 groups: intervention group (n=70), control group (patients recruited enrolled to the icu during the study period) and historical control group (admitted to the same icu in the period of 01.2019 to 12.2023). the intervention group will receive traditional chinese herbal medicine and/or acupuncture and/or low level laser applied on acupuncture points depending on tcm doctor decision and patient tcm diagnosis. intervention period will be 2 weeks. main outcomes include sequential organ failure assessment (sofa) score, icu length of stay, hospital length of stay, number of days of respirator uses and western medicine medication used study follow up will be 2 weeks.

Eligibility criteria:
inclusion criteria: * age 20 and above * surgical icu patients * the use of chinese medicine must be approved by the attending physician in the surgical intensive care unit exclusion criteria: * patients' family members refuse tcm intervention

Keywords: acupuncture chinese medicine organ failure intensive care
step-up intervention for self-management of fatigue in young adults receiving chemotherapy

Conditions: Young Adult, Cancer, Physical Activity

Summary: the purpose of the study is to determine the impact of a physical activity intervention on the self-management of fatigue in young adults receiving chemotherapy. half of the participants will receive an intervention which includes education and resources to set physical activity goals and monitor progress toward goals.

interventions to increase physical activity have been shown to relieve fatigue in patients receiving chemotherapy, but no studies have tested a physical activity intervention to improve fatigue in young adults receiving chemotherapy. this study will determine the impact of a physical activity intervention on the self-management process variables of self-efficacy and self-regulation and their relationships to physical activity and fatigue severity in young adults receiving chemotherapy.

Eligibility criteria:
inclusion criteria: * have a diagnosis of cancer; * are within the first two months of a chemotherapy regimen that will last at least another 3 months; * are ambulatory without assistance; * have written consent from their physician to participate; * have the ability to understand english; * have access to a computer and the internet. exclusion criteria: * symptoms of uncontrolled cardiopulmonary disease, neurological disease * delayed wound healing * high risk of bone fracture * pre-existing peripheral neuropathy
effect of intranasal corticosteroids on systemic allergen specific ige

Conditions: Seasonal Allergic Rhinitis

Summary: evaluation of the effect of fluticasone propionate vs placebo applied as nasal spray on the increase of allergen-specific serum ige levels following nasal exposure to recombinant allergens. nasal sprays will be applied for four weeks starting two weeks before nasal provocation and serum ige levels will be followed during eight weeks after nasal provocation.


Eligibility criteria:
inclusion criteria: * male or female 18-50 years of age * moderate to severe allergic rhinitis to grass and/or birch pollen for at least two seasons according to history * sensitization to rphl p 5 and rbet v 1 as demonstrated by unicap within a range from 3.0-80 kua/l and a positive (wheal diameter \>= 3 mm larger than the negative control and half of the histamine control) spt with rphl p 5 and rbet v 1 at 20 µg/ml * willingness to comply with the study protocol * written informed consent exclusion criteria: * perennial allergic rhinitis * history of asthma necessitating treatment * fev1 \<70% of predicted value * abnormalities at auscultation of heart or lungs * history of anaphylaxis * severe atopic dermatitis * total serum ige \>2000 ku/l * previous or ongoing immunotherapy (subcutaneous or sublingual) to grass or birch pollen * nasal provocation testing during the previous six month * known allergy/intolerance to fluticasone propionate or loratadine * known allergy/intolerance to cellulose, polysorbate, phenylethyl alcohol, benzalkonium chloride * contraindications for the use of incs: * acute or chronic infections of the upper respiratory tract * surgery of the nose during the previous year * hypersensitivity to components of the drug * contraindications for nasal provocation test * acute rhinosinusitis * acute allergic reaction of the immediate type at other organs * nasal polyposis or significant nasal anatomical deformities * vasomotor rhinitis * autoimmune disease, chronic or acute infectious disease, malignancy * severe psychological disorder * treatment with systemic or topical (intranasal, inhaled, external) corticosteroids from 3 month prior to the study * treatment with other immunosuppressant drugs from 6 month prior to the study * treatment with antihistamines or disodium cromoglycate from 2 weeks prior to the study * treatment with intranasal adrenergic drugs from 3 days prior to the study * treatment with systemic adrenergic drugs * treatment with psychopharmacological drugs from 2 weeks prior to the study * cardiovascular or pulmonary disease * contraindication for adrenaline * participation in any other clinical trial within the previous 3 month * pregnant, lactating or sexually active women with childbearing potential who are not using a medically accepted birth control method * a mental condition rendering the subject unable to understand the nature, scope and possible consequences of the study, and/or evidence of an uncooperative attitude * known alcohol or drug addiction or abuse * unlikelihood to be able to complete the study
paracervical block for pain control in first trimester abortion

Conditions: Legal Abortion With Complication; Pain

Summary: many woman undergoing a surgical abortion receive a paracervical nerve block for pain reduction, in which lidocaine (a numbing medication) is injected around the cervix. these injections numb the cervix and possibly the lower part of the uterus. however, the injection can be uncomfortable and it is not well known whether it is effective in reducing pain. the purpose of this study is to determine the level of pain women experience with a surgical abortion and the effect that paracervical block might have on that pain.

the investigators expect to have 120 women complete this study, between study sites at ohsu's center for women's health and planned parenthood columbia willamette in portland, or. every participant will still receive the standard oral medication for pain (ibuprofen) and anxiety (lorazepam). eligible subjects will be at least 18 years of age, less than 11 weeks pregnant and have already decided to have a surgical abortion. the primary outcome evaluated will be pain reported at time of cervical dilation. the investigators will assess pain at various time points (including secondary outcomes) immediately upon completion of the respective step and pain and satisfaction 30 minutes postoperatively.

Eligibility criteria:
inclusion criteria: * age: 18 years or older * voluntarily requesting pregnancy termination * ultrasound confirmed intrauterine pregnancy up to 10 6/7 weeks gestational age * good general health * english or spanish speaking * be able and willing to sign an informed consent and agree to terms of the study exclusion criteria: * gestational ages over 11 0/7 weeks, due to routine misoprostol use at our institutions * incomplete abortion * required or requested narcotics or iv sedation (prior to randomization) * patients who refuse ibuprofen and paracervical blocks * contraindications or allergies to lidocaine, ibuprofen or ativan * significant physical or mental health condition * adnexal mass or tenderness on pelvic exam consistent with pelvic inflammatory disease * patients with known hepatic disease * women, who in the opinion of the investigator are not suitable for the study protocol

Keywords: paracervical block pain control abortion
how does the clinical and paraclinical efficacy of an oral appliance evolved according to propulsion: control with each mm of advancement

Conditions: Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Respiratory Tract Diseases

Summary: the oammm study is a mono-centrer , non interventional, prospective study, carried out in ch valence oral appliance is indicated for first line moderate sleep apnea syndrome or severe sleep apnea syndrome after failure of positive airway pressure (cpap). clinical impact of each mm advancement of oral appliance is imperfectly assessed. the study aim to assess clinical and paraclinical efficacy of an oral appliance on each mm of advancement.

oral appliance will be delivered with a propulsion at 50% of the maximum advance and the investigator will titrate the advance according to the usual method polygraphy and clinical effectiveness of the oral appliance will be evaluate

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * moderate sleep apnea diagnosis with clinical signs * severe sleep apnea with failure continuous positive airway pressure( cpap) exclusion criteria: * previous sleep apnea treatment for moderate sleep apnea * refusal to participate in research * patient under guardianship, deprived of liberty, safeguard of justice

Keywords: oral appliance
volumetric monitoring in major lung surgery

Conditions: Pneumonectomy; Acute Pulmonary Edema

Summary: the hypothesis of this observational single-center clinical study was to explore the volumetric hemodynamic monitoring in the perioperative period in major and risky thoracic intervention. the investigators monitored the changes in the volumes of blood in the central vessels and heart chambers as well as a volume of fluid in pulmonary tissue (i. e. extravascular lung water).

the goal of this observational study is to investigate into changes in volumetric hemodynamic parameters obtained with a technique of transpulmonary indicator dilution after major thoracic intervention, including pneumonectomy and lobar resections. the important parameters of hemodynamics were monitored throughout the intervention and 48 hrs postoperatively, including extravascular lung water index, global end-diastolic volume index, etc.

Eligibility criteria:
inclusion criteria: * informed consent * age above 18 and below 80 * confirmed malignant bronchial neoplasm or * destructive pulmonary infection exclusion criteria: * pregnant * severe pulmonary hypertension * pulmonary tuberculosis * severe occlusive atherosclerosis of lower extremities

Keywords: postpneumonectomy pulmonary edema extravascular lung water