Kornimate/medical-research-clean huggingface dataset:
the effect of exercise on peripheral blood gene expression in angina

Conditions: Angina Pectoris

Summary: regular exercise is known to produce significant health benefits and to reduce the risk of heart diseases, although how this benefit occurs is not well understood. white blood cells are known to be involved in triggering heart attacks, and which genes are switched on or off in white blood cells determines whether they have beneficial or harmful effects. previous studies, and studies ongoing in our group, have demonstrated measurement of peripheral blood gene expression (which reflects white blood cell gene expression) is able to distinguish between patients with and without coronary artery disease, or patients who are able to develop good compared with poor coronary collateral arteries. therefore, the gene expression signature in peripheral blood may provide novel diagnostic or prognostic information, and insight into the pathogenesis of heart disease. we therefore hypothesise that exercise alters peripheral blood gene expression in patients with coronary artery disease and angina. this will identify possible ways that exercise improves angina and reduces the risk of heart disease.


Eligibility criteria:
inclusion criteria: * class i to iii angina pectoris (classified according to the canadian cardiovascular society \[ccs\])with documented myocardial ischemia or coronary artery disease on angiography * ability to read and speak english to a level allowing satisfactory completion of written questionnaires and to understand instruction during the exercise programme. exclusion criteria: * acute coronary syndromes or recent myocardial infarction (\<2 months) * left main coronary artery stenosis \>25% or high-grade proximal left anterior descending artery stenosis * known reduced left ventricular function (ejection fraction \<40%) * significant valvular heart disease * insulin-dependent diabetes mellitus * occupational, orthopedic, and other conditions that preclude regular exercise * patients whose ecg prevents interpretation of an exercise test (lbbb, rbbb, pacemaker implantation). * patients who already perform greater than 30min continuous exercise three times weekly (self-reported).

Keywords: angina gene expression depression anxiety
clinical utility study of a low-cost hand-held breast scanner

Conditions: Breast Cancer

Summary: the primary purpose of this study is to measure the clinical utility (accuracy) of the hand-held breast scanner (ibe) for the detection of breast lesions or lumps. the ibe results will be compared to the results of a current mammogram and/or ultrasound. the duration of study participation is approximately 30 minutes one day.

the fda approved class ii device in this clinical trial is a low-cost hand-held breast scanner (intelligent breast exam, ibe). this device is to be used a pre-screening tool for mammograms or ultrasounds. determination of the accuracy of ibe for the detection of clinically relevant breast lesions will be performed by means of a prospective study. the ibe evaluation will be performed by a trained licensed practical nurse or ultrasound technologist who is blinded to the outcome of the radiology studies at the time the ibe is performed. the ibe training will be done by the leading ibe user in the united states. the ibe evaluation will be done prior to the patient's original scheduled imaging visit. after the completion of the imaging visit the radiologist will evaluate the mammogram and/or ultrasound images along with the ibe report.

Eligibility criteria:
inclusion criteria: * 18 years of age and older * women and men with symptomatic breast lump (either by palpation or imaging) or * asymptomatic women presenting to the imaging center for a screening mammogram * signed informed consent exclusion criteria: * patients under 18 years of age * patients who previously participated in this study and are returning to the women's imaging center for follow-up diagnostic tests

Keywords: breast lump breast exam breast cancer screening breast lump detection
a study of mouth rinses in type 1 and type 2 diabetic participants

Conditions: Gingivits in Diabetics

Summary: the purpose of this study is to evaluate mouth rinse formulations for oral soft tissue tolerance and efficacy in plaque/ gingivitis prevention/reduction in type 1 and type 2 diabetics when used twice daily as an adjunct to tooth brushing during a twelve-week treatment period.


Eligibility criteria:
inclusion criteria: * adequate oral hygiene (that is brush teeth daily and exhibit no signs of oral neglect) * able to comprehend and follow the requirements and restrictions of the study (including willingness to use the assigned study products per instructions, availability on scheduled visit dates and likeliness of completing the clinical study) based upon research site personnel's assessment * negative pregnancy urine tests (females of child bearing potential only) * females of childbearing potential must be using a medically-acceptable method of birth control for at least one month prior to visit 1 and agree to continue using this method during their participation in the study * a minimum of 20 gradable teeth including 4 molars with scorable both facial and lingual surfaces.teeth that are grossly carious, extensively restored, orthodontically banded, abutments, exhibiting severe generalized cervical and/or enamel abrasion, teeth with veneers, or third molars will not be included in the tooth count * diabetes type 1 or type 2-self reported * an hb a1c level less than (\<) 7.0 percent (%) for type 1 diabetes and an hb a1c level of \<8.0% for type 2 diabetes * a mean gingival index greater than or equal to (\>=) 1.85 per the modified gingival index at baseline * a mean plaque index \>= 1.95 per the 6 site turesky modification of the quigley-hein plaque index at baseline exclusion criteria: * dental prophylaxis within four weeks prior to baseline visit * more than 3 sites having pocket depths of 5 millimeter (mm) or any sites that are greater than 5 mm in depth * history of medical conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures * a recent history of hypoglycemia requiring medical intervention within the past 30 days * use of antibiotics, anti-inflammatory or anticoagulant therapy, phenytoin sodium or diphenylhydantoin, calcium channel blockers, cyclosporin a, immunostimulants/ immunomodulators during the study or within the one month prior to the baseline exam. intermittent use of certain anti-inflammatory medication is acceptable at the discretion of the investigator
hematopoiesis in mbl and cll versus healthy age-matched control subjects

Conditions: Chronic Lymphocytic Leukemia; Monoclonal B-Cell Lymphocytosis

Summary: this study evaluates hematopoiesis to determine how mbl/cll affected bone marrow responds to fight off infections in the body.

primary objectives: i. determine the cellular and mechanistic basis of bone marrow (bm) hematopoietic dysfunction in untreated mbl and cll patients. ii. determine if mbl and cll b cell derived cellular products directly alter the differentiation and functional capacities of hematopoietic stem and progenitor cells (hspcs). iii. utilize the emu-tcl1 transgenic mouse model to determine how mbl and cll patient-derived cellular products alter bm hematopoiesis. outline: this is an observational study. patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.

Eligibility criteria:
inclusion criteria: * subjects in the cll cohort who are eligible for these studies will have a clinically established diagnosis of cll as assessed by flow cytometry and will include subjects who * remain untreated * are currently being treated * who have already been treated * subjects in the mbl cohort will have a clinically established diagnosis of mbl * healthy age-matched control subjects * healthy younger control subjects aged \> 40 years exclusion criteria: * anyone under 40 * healthy control subjects must not have a diagnosis of cll or mbl
personalized music therapy and agitation in dementia

Conditions: Alzheimer's Disease; Vascular Dementia

Summary: symptoms of agitation include abuse or aggressive behaviour toward self or others, appropriate behaviour performed with inappropriate frequency, or behaviours that are inappropriate according to social standards. in the later stages of dementia agitation can contribute significantly to patient distress and caregiver stress, and has been associated with poor quality of life. previous research studies have shown some evidence that personalized music played in daily care situations reduces agitation. the purpose of this study is to evaluate the effects of personalized music therapy via headphones on agitation during hygiene care (grooming). this study will involve 60 in-patients of the geriatric psychiatry ward of toronto rehabilitation institute. the study would take place over the span of 2 weeks and would involve listening to personalized and either non-personalized or no music during daily hygiene care (grooming). enrolment is completely voluntary and all personal data obtained will remain confidential.


Eligibility criteria:
inclusion criteria: * diagnosis of dementia with possible or probable cause of alzheimer's disease, vascular disease, mixed dementia; * moderate stage of dementia, a score of \<20 on mmse; * age 60 to 90 inclusive; * preserved hearing (hearing aids are permissible); * pittsburgh agitation scale score of ≥ 3 on at least on 3 occasions over a period of 5 days. exclusion criteria: * auditory deficits requiring correction beyond hearing aids. * no substitute decision maker available to indicate music preference and patient unable to answer for themselves. * recent acute event eg. mi, fractures, or major infection (not uti) * patients receiving standing orders of medication for personal care

Keywords: moderate dementia severe dementia alzheimer's disease vascular dementia agitation personalized music therapy
potential pulmonary benefit of low pressure laparoscopic cholecystectomy in selected patients

Conditions: Cholecystitis/Cholelithiasis; Cholecystitis; Gallstone; Polyp Gallbladder

Summary: standard pressure laparoscopic cholecystectomy，as the standard for cholecystectomy, can lead to about 15% of pulmonary atelectasis. according to literature, low pressure laparoscopic cholecystectomy is thought to probably decrease cardio-pulmonary related complications and postoperative pain. however, the previous studies have presented controversial results. our study aim to evaluate the potential pulmonary benefit of low pressure laparoscopic cholecystectomy in elderly or patients accompanied with cardio-pulmonary disorders.

standard pressure laparoscopic cholecystectomy, splc；12-16mmhg，as the standard for cholecystectomy, can lead to about 15% of pulmonary atelectasis. according to literature, low pressure laparoscopic cholecystectomy, lplc；8-10mmhg is thought to probably decrease cardio-pulmonary related complications and postoperative pain. however, most of the existing study have combined population with all age scale, bringing bias to the result. our study aim to evaluate the potential pulmonary benefit of low pressure laparoscopic cholecystectomy in elderly or patients accompanied with cardio-pulmonary disorders.

Eligibility criteria:
inclusion criteria: 1. aged 18-85; 2. patients receiving laparoscopic cholecystectomy due to benign gallbladder diseases; 3. older patient or accompanied by cardiopulmonary diseases (age\>60 years, hypertension, diabetes mellitus, coronary heart disease, arrhythmia, chronic bronchitis, emphysema, history of heart surgery, history of lung surgery, history of mediastinal surgery, asthma, et al); 4. aged older than 60, with or without the above diseases; 5. american society of aneshesiologists (asa) ii or higher; 6. informed consent acquired. exclusion criteria: 1. having contraindication of laparoscopic operations; 2. history at epigastric surgery. -

Keywords: low pressure; laparoscopic cholecystectomy
water, sanitation, and hygiene mobile health messages as an innovative tool to facilitate behavior change

Conditions: Cholera

Summary: develop a scalable approach for delivering water, sanitation, and hygiene (wash) messages to households in areas with confirmed cholera patients in dhaka, bangladesh. this will be done by conducting formative research through in-depth interviews, focus group discussions, and intervention planning workshops with households in areas with confirmed cholera patients and government officials to identify perceptions of wash behaviors and to inform the development of a mobile health intervention (mhealth) for this population. this intervention approach will then be piloted in a subset of households, and revised according to feedback. then the investigators will conduct a randomized controlled of the refined mhealth intervention.

aim 1. develop an evidence and theory based wash mhealth intervention for households in areas with confirmed cholera patients in dhaka, bangladesh through formative research 1. conduct formative research through in-depth interviews, focus group discussions, and intervention planning workshops with caregivers and household members of young children, and government officials to identify perceptions of wash behaviors and to inform the development of intervention materials. 2. pilot the wash mhealth intervention in a subset of households, and revise according to feedback. aim 2: evaluate the effectiveness of the developed wash mhealth intervention in increasing wash behaviors and reducing fecal contamination on hands and in stored drinking water by conducting a rct 1. recruit and prospectively follow for 12 months 120 households (600 participants, 4 per household) with a child under five years of age assigned to one of two study arms (60 households per arm). the first arm will receive the chobi7 mhealth program (chobi7 mhealth program arm) and the second arm will serve as a control arm and only receive a general message on oral rehydration solution (ors). 2. compare the 2 study arms using structured observation of handwashing with soap at stool and food related events, unannounced spot checks of the presence of soap in the cooking and latrine areas of the household, and fecal coliform counts on caregiver hands and in stored drinking water.

Eligibility criteria:
inclusion criteria: * at least one household member must report ownership of an active mobile phone in their possession on the day of enrollment exclusion criteria: * household has a tap or basin with running water inside their home.
intravital microscopy (ivm) in patients with peritoneal carcinomatosis (pc)

Conditions: Peritoneal Carcinomatosis

Summary: this study will investigate the tumor-associated vasculature of patients with peritoneal carcinomatosis, or cancer that spreads along the inner abdominal lining. the investigators will use a technology known as intravital microscopy (ivm) in order to visualize in real-time the tumor-associated vessels of peritoneal disease. the ivm observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

primary objective(s): to determine the feasibility and clinical utility of performing hivm in patients with peritoneal carcinomatosis during standard course of treatment (cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, or crs-hipec). secondary objective(s): 1. compare the microscopic observation of the tumor-associated vessels with normal tissue (peritoneal surface) in each individual subject. 2. correlate the microscopic observations of the tumor-associated vessels with pathologic grade of tumor implants. 3. correlate the microscopic observation of the microvasculature with tumor-specific and overall survival.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years of age. 2. have an ecog performance status of ≤ 2. refer to appendix c. 3. have measurable disease in the peritoneum by direct visualization (visible lesion typically \> 0.5 cm in maximal diameter). 4. carcinomatosis that meets indications for crs-hipec. 5. subject must understand the investigational nature of this study and sign an independent ethics committee/institutional review board approved written informed consent form prior to receiving any study related procedure. 6. a negative skin-prick test to fluorescein. exclusion criteria: 1. uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations. 2. renal dysfunction as defined as a gfr \< 45. 3. liver dysfunction as defined by child-pugh score \> 5, or lft's 1.5x above normal range. 4. any known allergy or prior reaction to fluorescein or icg or a positive skin prick test to fluorescein. 5. pregnant or nursing female subjects, determined preoperatively with a urine pregnancy test. 6. unwilling or unable to follow protocol requirements. 7. any condition which in the investigators' opinion deems the patient unsuitable (e.g., abnormal ekg). 8. any condition that excludes crs-hipec as the standard of care for the patient.
belfort dildy- obstetrical tamponade system post-marketing surveillance program

Conditions: Postpartum Uterine Bleeding

Summary: this is an open, post-marketing surveillance study obtaining data retrospectively on 300 women, of any age, treated with the bd-ots for postpartum uterine bleeding.


Eligibility criteria:
inclusion criteria: * treatment with the bd-ots device exclusion criteria: * none
postoperative analgesic effect of dexmedetomidine administration in wound infiltration for total abdominal hysterectomy

Conditions: Pain

Summary: the aim of this study was to investigate the analgesic efficacy of dexmedetomidine administration in wound infiltration for total abdominal hysterectomy.

abdominal hysterectomy is associated with moderate to severe postoperative pain, effective analgesia after hysterectomy essential and several techniques are used such as administration of opioids, nonsteroidal anti-inflammatory drugs and wound infiltration of local anaesthetics. different local anaesthetics can be used for the wound infiltration techniques.ifiltration of the surgical wound with bupivacaine following outpatient provides pain relief in the postoperative period , allows the early discharge from the outpatient surgical units.there has been increased interest in administration of analgesic prior to surgical injury. dexmedetomidine is a highly selective alpha-2 adrenergic agonist with sedative , anxiolytic, analgesic, sympatholytic and antihypertensive effects.dexmedetomidine has been used intravenously before initiation of anaesthesia and it has shown to provide some analgesic effect after surgery but there were some adverse hemodynamic effects. surgical wound administration of dexmedetomidine may be useful to avoid the adverse haemodynamic effects of intravenous administration while still providing the postoperative analgesia.

Eligibility criteria:
inclusion criteria: * 18-65 yo female * scheduled for elective hysterectomy * no known allergies to drugs * asa 1=2 patients exclusion criteria: * history of diabetes * history of chronic pain treatment * pregnancy

Keywords: dexmedetomidine wound infiltration postoperative analgesia
prospective trial for clinical validation of "qoca disposable ble thermometer "

Conditions: Fever

Summary: the purpose of this trial is to evaluate the accuracy and safety of the "qoca disposable body temperature patch" (q-temp-w1).

q-temp-w1 is a contact type body temperature patch developed by quanta computer co., ltd. it is mainly used to measure the body temperature of the human body. it can be used for general body temperature measurement, home temperature measurement records and medical tracking. both the european union and the us fda state that the clinical test methods of the temperature patch must comply with iso 80601-2-56. therefore, this test plan will follow the iso 80601-2-56 criteria to evaluate the accuracy of the temperature patch and follow it. the sampling age range and the fever/non-fever ratio are stratified, and clinical efficacy analysis is performed based on the measurement results. the main evaluation indicators include clinical bias, limits of agreement, and clinical repeatability.

Eligibility criteria:
inclusion criteria: * 1. male or female aged between 0-100 years. * 2. patient agrees to participate in the trial and sign informed consent. exclusion criteria: * 1. those who have any broken skin or skin diseases on the part of the body which is the test site of the ble thermometer, including the underarms and the back of the body. * 2. those whose test site of the ble thermometer are known to be contaminated by uncle arable body fluids, or lead to the inaccurate of the ble thermometer. * 3. those who have restlessness or other conditions that make them unable to tolerate the temperature measurement procedure.
auricular acupuncture on emotional distress in service members and veterans with ptsd

Conditions: PTSD and Substance Use Disorder; Emotional Distress

Summary: emotional distress (ed) refers to a state of mental suffering that significantly impairs an individual's ability to cope, often leading to a decline in overall well-being. in military contexts, ed is a prevalent concern due to the unique and demanding challenges faced by military personnel both in combat zones and during peacetime. the primary objective of this study is to assess the efficacy of integrating ear acupuncture with mindfulness therapy in mitigating ed and alleviating post-traumatic stress disorder (ptsd) symptoms among military personnel. the study will examine the effects of auricular acupuncture (aa) and mindfulness therapy (mt) on ed in military personnel with ptsd. the nada ear acupuncture protocol will be administered using acupuncture semi-permanent (asp), sterile needles placed in the bilateral ears, which will remain in place until they naturally fall out. mindfulness therapy will incorporate relaxation techniques, such as yoga and controlled breathing exercises, specifically designed to alleviate ed. a mixed-methods approach, integrating both quantitative and qualitative methods, will be employed concurrently to evaluate the interventions' effectiveness and to explore the participants' perceived benefits. specific aim 1: to evaluate the effectiveness and perceived benefits of the national acupuncture detoxification association (nada) ear acupuncture protocol as an adjunct therapy to brief mindfulness therapy for reducing emotional distress in service members and veterans with ptsd. specific aim 2: to examine the effectiveness of nada as an adjunct therapy to brief mindfulness therapy in improving sleep disturbances, alcohol use, and pain in service members and veterans with ptsd.


Eligibility criteria:
inclusion criteria: * active duty service member and veterans * a score of 14 or above on the abbreviated pcl 6-item * a score of 24 or above on the eds * agrees to participate in mindfulness therapy * able to provide informed consent exclusion criteria: - has had mindfulness therapy received from a healthcare provider in the past month