Kornimate/medical-research-clean huggingface dataset:
circulatory function in laparoscopic radical cystectomy for bladder cancer

Conditions: Circulatory Function; Laparoscopic Radical Cystectomy for Bladder Cancer

Summary: to optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(lpc) for bladder cancer through observation of perioperative changes of brain natriuretic peptide(bnp), stroke volume variation(svv), central venous pressure(cvp) and the use of transthoracic echocardiography(tte).

long term pneumoperitoneum and steep trendelenburg in lpc for bladder cancer influence perioperative circulatory function, resulting in a series of pathophysiological changes. bnp is of high sensitivity and specificity in the evaluation of cardiac function. svv and cvp are dynamic and static indices to predict fluid responsiveness. tte is a good indicator of volume and cardiac function.thus, we conducted the trial to assess the perioperative circulatory function in patients undergoing lpc. we hypothesized that long term pneumoperitoneum and steep trendelenburg in lpc for bladder cancer would increase perioperative blood volume and influence cardiac function.

Eligibility criteria:
inclusion criteria: * undergoing laparoscopic radical cystectomy for bladder cancer * asa i-ii exclusion criteria: * cardiac insufficiency * hepatic insufficiency * renal insufficiency

Keywords: brain natriuretic peptide pneumoperitoneum trendelenburg circulatory function laparoscopic radical cystectomy for bladder cancer central venous pressure stroke volume variation transthoracic echocardiography
recombinant anti-tumor and anti-virus protein for injection plus xeloda in treatment of metastatic colorectal cancer

Conditions: Metastatic Colorectal Cancer

Summary: the purpose of this study is to evaluate the efficacy and safety of recombinant anti-tumor and anti-virus protein for injection plus capecitabine in treating patients with metastatic colorectal cancer who have progressed after standard therapy.

this is a phase ⅱ exploratory clinical study. the purpose of this study is to evaluate the efficacy and safety of recombinant anti-tumor and anti-virus protein for injection plus capecitabine in treating patients with metastatic colorectal cancer who have progressed after standard therapy. all patients will receive recombinant anti-tumor and anti-virus protein for injection and capecitabine.

Eligibility criteria:
inclusion criteria: * aged above 18 years. * pathologically confirmed metastatic adenocarcinoma of the colon or rectum. all other histological types are excluded. * failure of second-line and more than second-line treatment, and fluoropyrimidine- and irinotecan- and oxaliplatin-containing regimens.(subjects who progress during or within 3 months following the last administration of approved standard therapies and terminate standard treatment due to unacceptable toxicity warranting.).if recurrence and metastasis occurred within 6 months after discontinuation of adjuvant chemotherapy, the adjuvant chemotherapy is considered to be first-line treatment.subject received last-line treatment not including capecitabine. * at least one measurable lesion according to the recist criteria that has not been previously local treated. minimum indicator lesion size as follows: greater than or equal to 10 mm measured by spiral ct or nmr.malignant lymph nodes short diameter as follows: greater than or equal to 15 mm measured by spiral ct. * ecog performance status 0, 1 or 2. * minimum of 4 weeks since any local radiotherapy or surgery for the control of symptoms or severe complications(local radiotherapy for the control of bone metastases is not the limit)，and adequately recovered from toxicities of any prior therapy). * life expectancy of at least 3 months. exclusion criteria: * prior treatment with novaferon. * pregnancy or breast-feeding women or women who may be pregnant were positive drug test before administration. * patient of child-bearing potential(male or less than 1 year postmenopausal women) were reluctant to take contraceptive measures. * patient who were allergic to interferon-α or who had interferon-α antibody. * patients with uncontrolled central nervous system (cns) metastases.

Keywords: metastatic colorectal cancer novaferon recombinant anti-tumor and anti-virus protein for injection xeloda
can thrombin generation measurement predict the risk of venous thromboembolism in acute ill patients

Conditions: Venous Thromboembolism

Summary: can thrombin generation measurement predict the risk of venous thromboembolism in acute ill patients traditional coagulation tests do not assess the whole coagulation system. thrombin generation assays measure the ability of plasma sample to generate thrombin following in vitro activation of coagulation. in contrast to the classical clotting assays, thrombin generation reflects and integrates all pro and anticoagulant reactions that regulate the formation and inhibition of thrombin. the aim of our study is to investigate whether thrombin generation would be able to predict a hypercoagulable state in acute ill patients admitted in the internal medical departments and how it correlates with the padua prediction score, a score that could assists the risk for venous thromboembolism in hospitalized medical patients. in total 300 patients are planned for inclusion in this trial. after signing an informed consent a blood sample will be obtained from each participant. we will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (cat).


Eligibility criteria:
inclusion criteria: * signed inform consent exclusion criteria: * pregnant women
a pharmacokinetic study of aa4500 (xiaflex™, proposed name) in subjects with dupuytren's contracture

Conditions: Dupuytren's Contracture

Summary: a phase 1, open-label, single-dose pharmacokinetic study in subjects with dupuytren's contracture conducted at one site in the united states. all subjects received a single dose of aa4500 0.58 mg, which was injected directly into the cord affecting either the metacarpophalangeal (mp) or proximal interphalangeal (pip) joint. pharmacokinetic blood samples were collected before dosing, at predetermined time points through the 24 hours after dosing, day 7, and day 30. efficacy and safety assessments were performed up to 30 days after the aa4500 0.58 injection. this study was designed to be part of the larger clinical program, for adult patients with dupuytren's contracture with a palpable cord, where the data from 2 pivotal placebo-controlled studies (aux-cc-857 \[nct00528606\]and aux-cc-859 \[nct00533273\]) and 7 non-pivotal studies were evaluated.


Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of dupuytren's contracture, with a fixed flexion deformity of at least one finger, other than the thumb, that had a contracture at least 20°, but not greater than 100° for mp (80° for pip) joints, caused by a palpable cord. * had a positive "table top test," defined as the inability to simultaneously place the affected finger(s) and palm flat against a table top. * were naive to aa4500 treatment. * were judged to be in good health. exclusion criteria: * had a chronic muscular, neurological, or neuromuscular disorder that affected the hands. * had received treatment for dupuytren's contracture within 90 days of the aa4500 injection to the mp or pip selected, including surgery (fasciectomy or surgical fasciotomy), needle aponeurotomy/fasciotomy, or injection of verapamil and/or interferon on the selected primary joint within 90 days before the first dose of study drug. * had a known recent history of stroke, bleeding, a disease process that affected the hands, or other medical condition, which in the investigator's opinion, would make the subject unsuitable for enrollment in the study.

Keywords: assessment of aux i and/or aux ii in human plasma
the effect of group-based laughter yoga on midwifery students

Conditions: Laughter Yoga

Summary: this study was planned to determine the effect of laughter yoga on the secondary traumatic stress and depression levels experienced by midwifery students due to the use of social media after the earthquake. the universe of the research will be the third year students of health sciences university hamidiye health sciences faculty midwifery department (n:84). a total of 8 sessions of laughter yoga, 2 sessions per week, will be applied to midwifery students in the intervention group of the research. it will be determined as intervention (n:42) and control (n:42) groups. "descriptive information form", "secondary traumatic stress scale for social media users" and "beck depression inventory" will be applied to both groups.

it was planned to determine the effect of laughter yoga on the secondary traumatic stress and depression levels experienced by midwifery students due to the use of social media after the earthquake. the study will be implemented according to the consort 2010 guidelines. the research will be carried out in health sciences university, hamidiye faculty of health sciences, midwifery department classroom. in pre-research classrooms; an environment with good lighting, sound systems and allowing individuals to move comfortably will be arranged. hamidiye faculty of health sciences midwifery department 3rd year students who volunteered to participate in the study will be determined as the intervention (n:42) and control (n:42) groups with the numbers assigned by the researchers via the https://www.randomizer.org/ site. an introductory information form will be applied to all students. a total of 8 sessions of laughter yoga, 2 sessions per week, will be applied to midwifery students in the intervention group of the research. laughter yoga will be practiced by researchers with leadership certification. each session will take an average of 45 minutes. each session will consist of groups of 7 people. before starting the laughter yoga session, an information meeting will be held with midwifery students who volunteered to participate in the study and were assigned to the intervention group. midwifery students will be administered "secondary traumatic stress scale for social media users" and "beck depression inventory" before and 4-6 weeks after the application. no intervention will be applied to the control group midwives, and "secondary traumatic stress scale for social media users" and "beck depression inventory" will be administered again when they are included in the study and 4-6 weeks later.

Eligibility criteria:
inclusion criteria: * being an active student in the 3rd year of health sciences university, hamidiye faculty of health sciences, department of midwifery * volunteering to participate in research exclusion criteria: * having a psychiatric diagnosis

Keywords: secondary trauma depression midwifery student earthquake
a danish nationwide longitudinal study on prevalence of periodontitis and its co-morbidities

Conditions: Periodontitis; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Rheumatoid Arthritis

Summary: the project (planperiomed) is a register-based study evaluating the associations and patterns of health care delivery between periodontitis and medical diseases using data from the danish dental record system dentalsuite (plandent a/s) and national danish health care registries with three overall hypotheses/ aims: * determine the extent to which periodontitis in registry data is associated with more odontological treatment services and treatment frequency. * determine if patients with systemic diseases attend dentists more frequently and receive more treatment services per patient than the population without these diseases. * determine to which extent periodontitis and received periodontal treatment affects the risk of medical diseases. the study will focus on association and trajectories of periodontitis and its treatment with three medical diseases, namely, type 2 diabetes mellitus (type 2 dm), cardiovascular diseases (cvd) and rheumatoid arthritis (ra). the dataset consists of approximately 4,000,000 people aged between 18 and 99 years attending private practice in denmark. the results from planperiomed study are likely to have ramifications for treatment guidelines for other periodontitis comorbidities, e.g. cvd and dm, and will thereby improve the quality of life for a wide range of patients and reduce long-term societal health care expenses related to periodontitis and its comorbidities.


Eligibility criteria:
inclusion criteria: * subjects with clinical registrations of dmft, periodontal status and corresponding treatment codes * self-reported systemic diseases including diabetes mellitus type 2, cardiovascular diseases and rheumatoid arthritis * subjects with clinical attachment loss\>=3mm, probing depth \>= 3mm and bleeding on probing (as defined by world workshop 2017- criteria for periodontitis) in clinical examination will be included in the study population. exclusion criteria: * subjects with more than 32 teeth * subjects with no clinical registrations

Keywords: periodontal diseases, periodontal index, periodontal bone loss, periodontal attachment loss, probing depth, bleeding on probing, clinical attachment loss diabetes mellitus 2, dm type 2, non-insulin dependent diabetes mellitus, uncontrolled diabetes mellitus type 2, increased blood glucose level cvd, cardiovascular risk, heart disease, heart disease risk factors smoking status, socio-economic status, register based, longitudinal study, danish nationwide study, systemic diseases
laryngeal injuries after anesthesia induction with sevoflurane and after anesthesia induction with rocuronium

Conditions: Laryngeal Injuries

Summary: anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.


Eligibility criteria:
inclusion criteria: * ear-nose-throat surgery * orotracheal intubation for surgery of the ear exclusion criteria: * obesity * allergy against the study drugs * patients with a known or suspected difficult airway (mallampati score 3 or 4 and a mouth opening \< 3.5 cm). * all patients were examined by stroboscopy one day before surgery and were excluded from the study when preexisting pathologies of the vocal cords were found

Keywords: laryngeal injuries vocal cord injuries hoarseness sore throat
evaluation of the epidermal langerhans cell population in aids / arc patients by the topical application of a potent contact allergen (1-chloro-2,4-dinitro-chlorobenzene) (dncb)

Conditions: HIV Infections

Summary: to evaluate the effect of application of dinitrochlorobenzene (dncb) on the number, morphology, and antigen expression of epidermal langerhans cells in aids and aids related complex (arc) patients.


Eligibility criteria:
inclusion criteria patients must have the following: * stage iii or iv hiv infection. * provide informed consent. exclusion criteria co-existing condition: patients with the following conditions or symptoms are excluded: * kaposi's sarcoma lesions in the proposed treatment sites. * liable to require radiation or chemotherapy during the course of the study. * not likely to survive the length of the study. * obvious ultra-violet-irradiated skin damage in the treatment areas and anyone with recent uv exposure or likely to have such exposure (e.g.: * holiday tans obtained in hawaii, members of uv box tanning salons, etc.) allergy to lidocaine. concurrent medication: excluded: * other immunomodulators. concurrent treatment: excluded: * radiation. patients with the following are excluded: * kaposi's sarcoma lesions in the proposed treatment sites. * liable to require radiation or chemotherapy during the course of the study. * not likely to survive the length of the study. * obvious ultra-violet-irradiated skin damage in the treatment areas. * allergy to lidocaine. prior medication: excluded: * prior dncb therapy.

Keywords: langerhans cells dinitrochlorobenzene acquired immunodeficiency syndrome aids-related complex
the role of naive t-cells in hiv pathogenesis

Conditions: HIV Infections

Summary: while hiv mainly infects mature t-cells it can also infect newly produced (or naïve) t-cells. these infected naïve t cells may then act a viral reservoir even in patients with undetectable viral loads. understanding when and how these cells are infected is important because it could help us to understand why patients fail therapy even if they have a persistently undetectable viral load.

the overall goal of this project is to provide a comprehensive analysis of the role of naïve t-cells in the pathogenesis of t-cell decline and long-term persistence of hiv infection. the study is divided into two parts. part 1 aims to determine the origin of hiv infected naïve t-cells in vivo by assessing the viral relatedness between hiv strains from naïve and memory cd4 t-cells. to do this we will be studying ten chronically infected individuals. naïve and memory cd4 t-cells from these individuals will be purified using a magnetic bead sorting (macs) strategy. envelope sequences will then be isolated and subjected to diversity calculation part 2 seeks to answer whether infection of naïve t-cells is established early in infection and what the effect of antiretroviral therapy is on this subset of t-cells. we will initially examine the relative proportion of cd31+ (recent thymic emigrants) and cd31- naive cd4+ t-cells in infected acute (n=15) and chronic (n=15) infection and uninfected (n=15) individuals compared with healthy controls. we will then prospectively test individuals prior to and at 3, 6, 12, 18 and 24 months following intiation of haart (highly active antiretroviral therapy) in individuals with acute (n=10) and chronic (n=10) hiv infection. immunophenotyping will detemine the proportion of naïve t-cells that are cd31+ and those that are cd31-. naïve and memory t-cell subsets will again be purified and total and integrated hiv dna will be quantified using real-time pcr.

Eligibility criteria:
inclusion criteria: - part 1: - hiv positive by elisa and western blot vl \>2,000, cd4 \>350 part 2: * hiv positive by elisa and western blot * established chronic infection (15 individuals) * acute infection (15 individuals). * any viral load or cd4 count. * no therapy. * any individual who initiates haart as determined by the treating physician exclusion criteria: * none

Keywords: hiv-1 naive t-cells cd31 treatment naive
music intervention and transcranial electrical stimulation for neurological diseases

Conditions: Disorder of Consciousness; Stroke

Summary: the goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. the main questions it aims to answer are: * to evaluate the residual neuroplastic processes in doc state related to music exposure * to determine the putative modulation of the aforementioned processes and the clinical outcome of doc patients by non-pharmacological strategies, i.e., electric (tdcs) and music stimulation * to evaluate the impact of this intervention on caregiver's burden and psychological distress. participants will be randomly assigned to one of three different music-listening intervention groups. primary outcomes will be clinical, that is based on the neurologist's observations of clinical improvement, and neurophysiological, collected pre-intervention, post-intervention and post-placebo.


Eligibility criteria:
inclusion criteria: * age \> 18 years * post-stroke aphasia * post-stroke neglect * patients with disorders of consciusness (doc) exclusion criteria: * no auditory injury * no hystory of neurological disease * no hystory of psychiatric disease * previous stroke * use of alcohol and drugs * premorbid dementia

Keywords: music stimulation tdcs aphasia neglect doc stroke
prior statin use and risk of chf, alo and malignant arrhythmia in indonesian post-acute coronary syndrome patients

Conditions: Acute Coronary Syndrome; Acute Pulmonary Edema; Arrhythmias, Cardiac; Heart Failure

Summary: this study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of heart failure, acute lung edema, malignant arrhythmia and death in acs patients.

adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under icd-10 coding of i24.9 without a prior history of heart failure, acute lung edema and arrhythmia were included in this study. the inclusion criteria are patients with primary diagnosis of i24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. participants were grouped into 2 groups - statin and non-statin based on prior history of statin use prior to acs. diagnosis of acs was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record. data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. outcomes of interest were defined as either concomitant heart failure, acute lung edema, malignant arrhythmia, mortality or combinations of them as diagnosed in the medical records. heart failure is defined based on echocardiographic findings from the medical records. acute lung edema is defined based on medical records or reported clinical findings of lung edema - rhonchi reported in 1/3 of the lungs with oxygen saturation \<90%. whereas malignant arrhythmia is defined as the presence of ventricular tachycardia (vt) or ventricular fibrillation (vf).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute coronary syndrome * presence of detail on statin prescription history exclusion criteria: * history of heart failure, acute lung edema and arrhythmia * unavailability of electrocardiographic findings, cardiac marker results * incomplete records of prior medical and treatment history

Keywords: acute coronary syndrome statin acute pulmonary edema malignant arrhythmia heart failure
exercise and prediabetes after renal transplantation

Conditions: PreDiabetes; Kidney Transplantation

Summary: the present clinical trial, expred-ii, is the continuation of expred-i (nct04489043). objective: to evaluate the feasibility of exercise in the reversibility of prediabetes after transplantation, as a first step to prevent post-transplant diabetes mellitus (ptdm). methodology: a total of 50 patients with prediabetes beyond 12 months after transplantation with capacity to perform exercise will be randomized to standard life-style recommendations as per clinical practice (n=25) or to a stepped ad-hoc designed training intervention (n=25). prediabetes will be diagnosed based on fasting glucose levels and an oral glucose tolerance test (ogtt). patients randomized to exercise will start with aerobic exercise training 5 times/week, 30 min/day for 12 months which may be gradually increased to 60 min/day or combined with strength exercise in the last increment in case of prediabetes persistence. the reversibility/persistence/relapse of prediabetes will be measured with fasting glucose and ogtt every 3 months. the study will last 12 months.


Eligibility criteria:
inclusion criteria: * ≥ 18 years * ≥ 12 months post kidney transplant * stable renal function in the last 3-6 months * prediabetes (abnormal fasting glucose 100-125 mg/dl and/or glucose intolerance 140-199mg/dl) * ability to perform exercise exclusion criteria: * infection, cancer, acute cardiovascular disease, advanced kidney disease, pulmonary hypertension and uncontrolled chronic liver disease. * inability to understand the protocol * severe psychological illness * ptdm and/or dm prior to transplantation * morbid obesity

Keywords: adherence post-transplant diabetes mellitus prediabetes renal transplantation therapeutic exercise