Kornimate/medical-research-clean huggingface dataset:
investigation of biopsychosocial characteristics of individuals with knee osteoarthritis

Conditions: Osteoarthritis (OA) of the Knee

Summary: since pain and depression are observed together in rheumatic diseases, the concept of limitation caused by the disease and health-related quality of life becomes more determinant than radiological joint damage. sleep problems observed in oa also increase the level of depression findings and difficulty in movement. the chronic nature of the disease includes issues such as pain, fatigue, sleep problems, loss of function, anxiety, depression, and social isolation, together as in other chronic diseases. this complex structure accompanies a picture in which inflammatory processes are triggered. when the literature is examined, the necessity of evaluation and methods including all these biopsychosocial characteristics of chronic diseases with multifaceted symptoms is emphasized. on the other hand, although it is stated that the common goal of non-pharmacological treatments is to contribute to biopsychosocial improvement in the patient, it is emphasized that evaluations with biopsychosocial content are insufficient. this situation causes the need for scales that provide a holistic assessment of chronic diseases. when the literature, including individuals diagnosed with osteoarthritis, is analyzed, the inadequacy of the studies providing biopsychosocial evaluation draws attention.


Eligibility criteria:
inclusion criteria: * diagnosis of knee osteoarthritis according to acr knee osteoarthritis diagnostic criteria * being in stage 2 or 3 according to kellgren-lawrence radiological staging criteria * to be 18 years of age or older * being a reader-writer * having read and signed the informed consent exclusion criteria: * history of major psychiatric illness * having malignant disease * having chronic infectious or other rheumatologic diseases * serious knee trauma or surgical operation in the last 6 months * having collagen tissue disease * history of peripheral vascular disease or neuropathy * being in stage 4 according to kellgren lawrence radiologic staging criteria * to have received a physiotherapy program for the relevant knee in the last 3 months

Keywords: osteoarthritis biopsychosocial depression social isolation pain sleep functionality
treatment development for glucose transporter type i deficiency syndrome (g1d)

Conditions: Glucose Transporter Type 1 Deficiency Syndrome; GLUT1 Deficiency Syndrome

Summary: the purpose of this trial is to determine if an alternative energy source will impact brain metabolism in a disorder characterized by glucose metabolism failure in the brain. the central hypothesis tested in this investigation is whether circumventing impaired glucose metabolism is feasible, safe and potentially promising by supplying anaplerotic precursors through metabolism of odd-carbon fatty acids that can enter the citric acid cycle (cac) through alternative metabolic pathways.

triheptanoin, a nutritional supplement long used in other metabolic disorders and also added to foods and cosmetics, will be used to complement any diet that g1d patients may be receiving at enrollment with the exception of the ketogenic diet.

Eligibility criteria:
inclusion criteria: * male or female * ages 1 month to \<21 years of age * diagnosed with glucose transporter type i deficiency. * age matched (within 1 year) controls not diagnosed with g1d. exclusion criteria: * all subjects carrying body metal implants incompatible with the exposure to a magnetic field * subjects unable to tolerate the mri and mrs procedures due to anxiety * subjects receiving oxygen supplementation or those confined to a bed or stretcher * subjects currently receiving a ketogenic diet, due to a high risk of seizure recurrence while transitioning off ketosis. * patients behaviorally unable to hold still for imaging procedures (rather than limited by seizure activity) will be excluded.

Keywords: g1d glut1 disorder glucose transporter type 1 disorder glucose transporter type i disorder
effects of xiidra on closed eye tear film leukocytes in dry eye disease

Conditions: Ocular Discomfort; Ocular Inflammation; Dry Eye; Contact Lens Complication; Keratoconjunctivitis Sicca

Summary: every night during sleep, there is an accumulation of white blood cells in the closed eye. the closed eye white blood cells are predominantly neutrophils, but there is a small population (3%) of t cells. the effects of these closed eye white blood cells on dry eye disease pathogenesis have yet to be fully elucidated, but preliminary evidence suggests that closed eye neutrophils may have an associated hyperactivity and increased degranulation in dry eye disease that could contribute to epithelial instability. as an anti-t cell therapy, xiidra offers an opportunity to better understand how the closed eye white blood cells are recruited and activated. this study also seeks to verify the proposed mechanism of action.


Eligibility criteria:
inclusion criteria: * able to understand and sign an informed consent and hipaa privacy document * greater than 18 years of age at time of informed consent * able and willing to follow protocol instructions * capable of performing at-home eye wash * must be willing to drop off samples and comply with study visit procedures * for contact lens wearers, must wear lenses at least four hours per day, four days per week exclusion criteria: * current cigarette smokers * current participation in any investigational drug or device study. if subjects choose to participate in another investigational drug or device study, they will be discontinued from this study protocol. * current pregnancy or nursing as indicated by self-report. while not a safety issue, pregnancy or nursing influences the biochemical composition of the tear film. * any systemic health conditions that alter tear film physiology * a history of ocular surgery within the past 12 months * any active ocular infection or inflammation * any present use of accutane or ocular medications * any history of significant adverse reaction to lifitegrast or other components of the drug product, or contraindication to the use of lifitegrast or other components of the drug product * any prior exposure to lifitegrast. * for normal and dry eye subjects, any history of contact lens wear within the past three months. * for contact lens wearers, any change of soft contact lens brand or care solutions within 30 days prior to screening or any anticipation of changing current type/brand of contact lenses or care solutions throughout the 84 day study * any condition, which in the examiner's opinion, may put the subject at significant risk, confound study results, or interfere with their participation in the study.

Keywords: dry eye disease neutrophil t cell lifitegrast contact lens discomfort ocular surface homeostasis
validity and reliability of smartphone use in measuring joint position sense in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: this study will investigate the concurrent validity and intra-rater reliability of using smartphone in assessing joint position sense in patient with knee osteoarthritis.

knee osteoarthritis is the most common arthritis. such disease is complicated by many musculoskeletal dysfunction such as disturbed joint position sense, which impairs their ability to perform their regular daily activities. as rehabilitation should target impairment in function, it is essential that therapists assess joint sense during baseline and follow-up evaluation of patients to decide on needed therapeutic interventions. joint position sense can be assessed by various methods such as motion tracking systems and the isokinetic dynamometer, yet these equipment are expensive and are not readily available at regular clinical settings. smartphone has been introduced as an assessment tool in rehabilitation of musculoskeletal disorders. for the knee joint, smartphone has been validated for measuring range of motion and joint position sense in healthy population, yet it has never been validated in patients with knee osteoarthritis. therefore, this study will investigate smartphone validity and reliability as an assessment tool of knee position sense in patients with knee osteoarthritis.

Eligibility criteria:
inclusion criteria: * patient must be referred to the outpatient clinic of the faculty of physical therapy and medicine, cairo university with a confirmed diagnosis of unilateral or bilateral osteoarthritis of the knee and having one or more of the following criteria (aso, 2000). * morning stiffness for less than 30 minutes. * crepitus on active knee movement. * bony enlargement either palpable or visible in radiographs. * bony tenderness at joint margins. * age 40-60 years old. exclusion criteria: * steroid injection within 2 months prior to inclusion. * presence of neurologic disorders (e.g., stroke, parkinson's disease, or poliomyelitis). •presence of other rheumatoid or orthopedic disorders in the lower extremity or spine. •a recent history of a lower extremity fracture with in the past year. * history of ligament deficiency, such as anterior cruciate ligament or meniscal injury. * severe pain with active movement. * poor memory or cognitive function.

Keywords: position sense smartphone validity reliability knee osteoarthritis
idiopathic pulmonary fibrosis (ipf) and the 3 minutes sit-to-stand test

Conditions: Idiopathic Pulmonary Fibrosis

Summary: this study is designed to evaluate the reproductibility and the performance of the 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis. to do this, the investigators are recruiting 40 patients with idiopathic pulmonary fibrosis in 2 centers (grenoble university hospital and lyon university hospital). patients had to achieve an effort test on a cycle ergometer. 2 visits are planned in the hospital. during each visit, patients will perform a 3 minutes sit-to-stand test, a 1 minute sit-to-stand test and a 6 minutes walk test. during the second visit, patients will also perform a 3 minutes sit-to-stand test with measurement of oxygen uptake. the investigators will then analyse the results by comparing numbers of cycle, functional response and symptoms during the 3 minutes sit-to-stand test of the 2 visits. the investigators will also compare the functional response obtained during the 3 minutes sit-to-stand test, the 1 minute sit-to-stand test and the 6 minutes walk test. finally, the investigators will compare the maximal values of oxygen uptake, respiration rate and expired volume obtained during the 3 minutes sit-to-stand test to the effort test on cycle ergometer.


Eligibility criteria:
inclusion criteria: * man or woman aged less than 85 years * patients with idiopathic pulmonary fibrosis without any acute exacerbation during 4 months before the inclusion * non-opposition to participation in research * patient with 6 minutes walk test \> 200 meters (with or without oxygen therapy) exclusion criteria: * patient with reduced locomotor activity, or joint pain that compromises the performance of the tests * patient with 6 minutes walk test \< 200 meters * patient with an other etiology of pulmonary fibrosis * other significant pulmonary diseases * patient with unstable cardiac disease * patient who may be, according to the investigator's assessment, not cooperating or respecting the obligations inherent in participating to the study. * opposition to participation in research

Keywords: idiopathic pulmonary fibrosis 3 minutes sit-to-stand test interindividual reproductibility
microwave ablation with splenic artery occlusion for secondary hypersplenism

Conditions: Secondary Hypersplenism

Summary: this study assesses the effectiveness of microwave ablation of the spleen in conjunction with splenic artery occlusion for treating secondary hypersplenism.

this open-label, single-arm, single-center clinical trial investigates the combined approach of microwave ablation of the spleen and splenic artery occlusion for managing secondary hypersplenism.

Eligibility criteria:
inclusion criteria: * 1. written informed consent signed prior to enrolment 2. age \> 18 years, both sexes 3.patients with severe hypersplenism secondary to cirrhosis with clinical diagnosis, white blood cells \<3×109/l, and/or platelet \<50×109/l 4.patients who have been repeatedly given drugs to raise white blood cells and platelets in clinical practice have poor effect 5.mental problems such as clinical symptoms or anxiety in patients require interventional treatment for hypersplenism exclusion criteria: * patients with any of the following are not eligible for enrollment in this study 1. coagulopathy or other blood disorders 2. recent use of anticoagulant drugs 3. severe hypertension and cardiac insufficiency 4. bone marrow aspiration results showed bone marrow suppression 5. combined with other spleen malignant diseases 6. severe skin infection at the puncture site 7. participated in other clinical studies within 2 months prior to the start of the study 8. patient or his/her authorized person is unwilling to sign a written informed consent form or unwilling to comply with the study protocol
rev 002 observational study of the revent sleep apnea system: minimally invasive treatment for obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this post-market observational study is to assess the effectiveness and patient perception of benefit of the revent sleep apnea system in patients diagnosed with obstructive sleep apnea due to primary tongue base closure. the revent sleep apnea system is a minimally invasive surgical approach to treat obstructive sleep apnea. the revent sleep apnea system consists of an implanter kit and tongue implants. the implants are permanently implanted in the tongue during a minimally invasive outpatient surgical procedure to prevent tongue base closure during sleep.


Eligibility criteria:
inclusion criteria: * patient diagnosed with obstructive sleep apnea due to primary tongue base closure. * ahi ≥ 10 and ahi ≤ 40 (at least 90% of apneas and hypopneas must be obstructive). * bmi ≤ 32. * confirmation of tongue base closure as the primary source of obstruction with drug induced sleep endoscopy (dise). exclusion criteria: * patient with prior tongue-base surgery * uvulopalatopharyngoplasty, soft palate surgery, tonsillectomy or minimally invasive rf ablation of the tongue within the last six (6) months. * history of mandibular and/or hyoid advancement to treat osa. * any contraindications as listed in the approved instructions for use.

Keywords: obstructive sleep apnea obstructive sleep apnea due to primary tongue base closure minimally invasive surgery revent sleep apnea system tongue implants
exploration of stellate ganglion block in patients with cerebral small vessel disease

Conditions: Cerebral Small Vessel Diseases

Summary: this is a prospective study conducted on patients with cerebral small vessel disease, dysphagia and cognitive impairment. they were divided into the comparison group and observation group evenly. all the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. the swallowing function, cognitive function and activities of daily living of the two groups of patients before and after treatment were evaluated by penetration-aspiration scale, mini-mental state examination and modified barthel index.

this study is conducted for exploration of stellate ganglion block in patients with cerebral small vessel disease. this is a prospective study conducted on patients with cerebral small vessel disease, dysphagia and cognitive impairment. they were divided into the comparison group and observation group evenly. all the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. the swallowing function, cognitive function and activities of daily living of the two groups of patients before and after treatment were evaluated by penetration-aspiration scale, mini-mental state examination and modified barthel index.

Eligibility criteria:
inclusion criteria: * age\>18 years. * meeting the diagnostic criteria for cerebral small vessel disease. * dysphagia confirmed by videofluoroscopic swallowing study * mini-mental state examination (mmse)\<27, indicating the existence of cognitive impairment. * no history of prior stroke. * stable vital signs. exclusion criteria: * dysphagia that might be caused by other diseases that might cause dysphagia, such as head and neck tumors, traumatic brain injury, myasthenia gravis, etc. * cognitive impairment that might be caused by other diseases, such as alzheimer's disease, parkinson's disease, brain injury, etc. * neurological blockade contraindications such as bleeding tendency, blocked site infection. * unable to successfully finish the assessment of this study. * complicated with severe liver and kidney failure, tumors, or hematological disorders. * simultaneously in need to undergo other therapy that might affect the outcomes of this study. * pregnant or nursing females
a mindfulness program (mbsr) in the management of symptomatic hip and knee osteoarthritis

Conditions: Osteoarthritis; Mindfulness; MBSR

Summary: symptomatic osteoarthritis (oa) is the most common joint disease and the leading cause of disability in industrialized countries. therapeutic approaches to prevent the development and progression of osteoarthritis are disappointing and very limited. new therapeutic alternatives seem essential to better manage his daily life. non-drug approaches, including psycho-corporal approaches are increasingly used in the management of chronic pain. mindfulness is a technique of attention training, which is to focus one's attention on the present moment and to examine the sensations that come to mind, how they appear, how they last time, and how they disappear. regarding rheumatological pathologies, a mindfulness program (mbsr) has shown its effectiveness in chronic pain; and in particular in osteo-articular localization, such as chronic low back pain. a recent study found a correlation between a pre-disposition to mindfulness and less pain and / or better quality of life in patients with knee osteoarthritis. however, to the knowledge of investigator, no study has evaluated the effectiveness of an intervention based on a mindfulness training program as a therapeutic alternative in osteoarthritis of the knee or hip. the goal of investigator is to evaluate, using a randomized, controlled study, the effect of a mindfulness program (according to the mbsr protocol) on pain, function, psychological state and quality of life patients with knee or hip osteoarthritis


Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee or hip (kellgren and lawrence x-ray stage ≥ 2) * mean pain vas on at least one reference joint (knee or hip)\> 40 mm during the last week * stable treatment with analgesics for at least a week exclusion criteria: * corticosteroids (oral or injectable) in the month prior to inclusion * intra-articular injection of hyaluronic acid in the last 3 months prior to inclusion * inflammatory rheumatic disease (rheumatoid arthritis, spondyloarthritis, ccpd) * current depressive episode * psychotic disorders * usual practice of a relaxation method (mindfulness, yoga, sophrology ...) * major protected by law (guardianship, curatorship or under the safeguard of justice) * subject in a period of exclusion relative to another protocol or for which the annual amount maximum compensation of € 4500 has been reached. * subject participating in another research protocol * subject not affiliated to a social security * pregnant woman, parturient or nursing, patient unable to give her major consent protected, vulnerable persons (articles l.1121-6, l.1121-7, l.1211-8, l.1211-9) * subject deprived of liberty by judicial or administrative decision

Keywords: osteoarthritis mindfulness mbsr
acute effects of acupuncture in the response of the median neurodynamic test

Conditions: Other Lesions of Median Nerve

Summary: the purpose of this study is to test whether the application of acupuncture alters the mechanical (range of elbow extension motion) and physiological (eg, intensity and onset of discomfort, tingling feeling and/or feeling of tension or restriction of movement) responses of the neurodynamic test of nerve median in asymptomatic individuals

to understand the potential of acupuncture therapy in pain syndromes that involve changes of the mechanics and physiology of the peripheral nervous system

Eligibility criteria:
inclusion criteria: * age \> 18 years-old * normal mobility in the joints of the upper quadrant exclusion criteria: * pathology that may impair nerve function (eg, diabetes) * complaints over the past 3 months in the upper quadrant * significant deformities in the upper quadrant

Keywords: acupoints acupuncture therapy median nerve biomechanics
thermoregulatory reactions of medical workers who use personal protective equipment from biological hazards

Conditions: Overheating

Summary: this research will provide data on thermal condition, functional status and working conditions of medical workers who use personal protective equipment from biological hazards. acquired data will be used to define acceptable period of use for these protective costumes.

this research will recruit 14-20 volunteers. during 8 hours each subject will perform their work using protective costume. heart rate, electrocardiogram, oxygenation, skin and air temperature under costume and hygrometric data will be registered. also there will be questionnaires for volunteers for subjective assessment of thermal and moisture sensations and assessment of working conditions.

Eligibility criteria:
inclusion criteria: * healthy individuals (based on medical screening) exclusion criteria: * endocrinological diseases and disorders * health deviations at the time of the study

Keywords: thermophysiology personal protective equipment from biological hazards medical workers covid-19 working conditions