Kornimate/medical-research-clean huggingface dataset:
diagnosis of hallux valgus by using a foot pressure platform as an alternative to radiological images

Conditions: Hallux Valgus

Summary: hallux vagus is a common deformity which affects the first metatarsalphalangeal joint. the current diagnostic tool is using x-ray which is expensive and includes radiation exposure. the current study is aimed at using the foot pressure platform as an alternative method for diagnosis and evaluation of the deformity. the main subjects will be recruited from orthopaedic outpatient clinics. the recruited subjects will undergo the non-invasive and radiation free study by walking on a pressure platform. then their pressure data will be correlated with their radiological study which has already been done in the clinic. the aimed outcome of the study is use the foot pressure platform as first line of diagnosis and evaluation of the hallux valgus deformity.


Eligibility criteria:
inclusion criteria: * patients who are diagnosed with hallux valgus. * patients who are diagnosed with hallux valgus and scheduled for surgery ( to be seen pre and post-surgery) * patient who are diagnosed with hallux valgus and had surgery exclusion criteria: * any other foot deformity * previous foot surgery (which is not related to hv
a pilot trial of interpersonal psychotherapy for the treatment of depression in patients with prostate, colorectal, lung and pancreatic cancer

Conditions: Depression; Pancreatic Cancer; Lung Cancer; Colon Cancer; Prostate Cancer

Summary: there is now overwhelming evidence documenting the efficacy of psychotherapy in the treatment of depression in the general population. surprisingly, however, given the high prevalence of depression in cancer patients, there are very few studies on the efficacy of psychotherapy in this population. published studies of psychotherapy in cancer patients generally include patients with high heterogeneity of psychiatric diagnosis and frequently include patients without a psychiatric diagnosis, with the aim of preventing the appearance of a psychiatric disorder. this heterogeneity complicates the interpretation of the efficacy and specificity of these interventions. specifically, the efficacy of psychotherapy for major depression in patients with cancer is unknown.

interpersonal psychotherapy (ipt) is a brief, manualized therapy that has shown efficacy in the treatment of major depressive disorder (mdd) in several controlled trials. this study will test the efficacy of ipt in a group of prostate, colorectal, lung and pancreatic cancer patients with a diagnosis of major depressive disorder. we will test the efficacy of ipt using a variety of outcome measures at different time points of the treatment. those scales will evaluate the patient's depressive symptoms, psychosocial functioning and quality of life. patients that are deemed eligible for the study will have ipt for twelve weeks. patients will receive twelve 50-minute sessions over 16 weeks. to facilitate access to treatment, sessions 1,2,3,4, 8 and 12 will be in person, while all others will in be person or over the telephone according to the patient's choice. sessions will be audiotaped and periodically reviewed by experienced supervisors to assess therapist's adherence to ipt technique. this taping will be optional and is covered in a separate consent form. this pilot study is to prove feasibility and acceptability of ipt in this population and to show preliminary efficacy.

Eligibility criteria:
inclusion criteria: * a primary psychiatric diagnosis of major depressive disorder as defined by dsm-iv * diagnosis of prostate, colorectal, lung or pancreatic cancer (stage 1-4) * a score of 16 or above in the 17-item ham-d (hamilton depression scale) * male or female ages 18-75. * ability to give consent * english and/ or spanish speaking exclusion criteria: * lifetime history of psychosis or bipolar disorder * history of substance abuse or dependence in the three months prior to the study. * current suicide risk. * patients who have ever failed ipt in the context of cancer. * patients who are receiving effective medication for depression * patients with t3, t4 and ths abnormal values

Keywords: depression psychotherapy cancer pancreatic cancer lung cancer colon cancer prostate cancer
estimation of gestational age by tcd

Conditions: Gestational Age and Weight Conditions

Summary: - different parameters are used to estimate gestational age ac, hc , bpd and fl

-tcd is one of the parameters ,here we are testing its accuracy in calculating ga

Eligibility criteria:
inclusion criteria: * pregnant ladies with ga between 16 - 40 weeks exclusion criteria: * pregnant ladies with ga less than 16 weeks
a clinical trial to evaluate the safety, tolerability and preliminary effectiveness of single administration intradiscal rhgdf-5 for the treatment of early stage lumbar disc degeneration

Conditions: Early Lumbar Disc Degeneration

Summary: study to show the safety, tolerability and preliminary effectiveness of intradiscal rhgdf-5 in subjects with early lumbar disc degeneration


Eligibility criteria:
inclusion criteria: 1. persistent low back pain with at least 3 months of non-surgical therapy at one suspected symptomatic lumbar level (l3/l4 to l5/s1) as confirmed using a standardized discography protocol. the required discography protocol will be provided by the sponsor. subjects with multilevel disease must have a provocative discogram confirming that only 1 level is symptomatic at least 2 weeks prior to administration, with an expiry of 12 months from the date performed. 2. oswestry disability index (odi) for low back pain of 30 or greater 3. low back pain score greater than or equal to 4 cm as measured by visual analog scale (vas) at visit 1 baseline 4. male or female 18 years of age or older exclusion criteria: 1. persons unable to have a discogram, ct, or mri 2. abnormal neurological exam at baseline (e.g., chronic radiculopathy) 3. active radicular pain due to anatomical compression such as stenosis or disc herniation (radicular pain is defined as pain below the knee) 4. extravasation of contrast agent during the discogram into the epidural space (does not include leakage of contrast agent along the needle track or leakage to the outer annular ring at the posterior longitudinal ligament vicinity) 5. suspected symptomatic facet joints and/or severe facet joint degeneration at the index level or adjacent segments
quality of life in lung cancer survivors

Conditions: Lung Cancer Survivors

Summary: the purpose of this study is to find out about the quality of life of individuals who have been diagnosed and treated for lung cancer (lung cancer survivors). by quality of life, we mean how you are feeling about different aspects of your life, including your physical health, your emotional health, and your ability to carry out daily activities. we are interested in people's opinions about their quality of life, as well as the factors that affect their quality of life. learning about quality of life will help us to develop new services for lung cancer survivors.


Eligibility criteria:
inclusion criteria: * diagnosis of primary stage ia or ib nsclc; * underwent surgical resection for nsclc at mskcc; * from 1 to 5 years and 11 months post-treatment for nsclc prior to study recruitment; * no evidence of disease (ned) at the time of recruitment; * can be reached by telephone; * able to provide informed consent. exclusion criteria: * undergoing active antineoplastic treatment; * major psychopathology or cognitive impairment likely in the judgment of the investigator to interfere with participation and compliance with the protocol.

Keywords: lung cancer survivors
freestyle prosthesis for aortic root-replacement with and without hemiarch replacement

Conditions: Aortic Aneurysm; Aortic Dissection; Endocarditis; Root Abscess; Valve Heart Disease

Summary: the freestyle® prosthesis (medtronic plc, dublin, ireland) is a biological, porcine aortic root implanted in various combinations and techniques since the 1990s. the main indication for the choice of this prosthesis is a combined pathology with degenerated aortic valve and additional dilatation of the root often involving the ascending aorta. the freestyle® prosthesis is also used in cases of dissection of the ascending aorta with the involvement of the aortic valve, which opens the debate on how far the ascending aorta should be replaced for a sustainable solution with calculable low periprocedural risk. considering a lower intraoperative risk in the life-threatening situation, an extended resection of the aorta can be avoided and only the aortic root replaced with a piece of ascending aorta. on the contrary, focusing on improved long-term outcome, the technique of total arch replacement in aortic dissection was developed in emergency situations with acceptable results, which, however, were often reproducible only in large, experienced centers. apart from the abovementioned options, the technique of proximal arch replacement can provide a tension-free anastomosis. the intention of hemiarch replacement is the attachment of the prosthesis to an aneurysm-free portion of the aortic arch helping to protect against further anastomotic aneurysms and spare the patient complex reoperation or interventional procedures in the future. as a possible drawback of the technique, especially in emergency situations, the potentially prolonged duration of surgery and the need of selective brain perfusion via axillary or carotid artery are discussed increasing the risk of stroke and further major events, which could not be reflected in current literature. however, there is still no convincing evidence of a long-term benefit in terms of re-operation and survival after hemiarch replacement. the aim of this retrospective analysis was to assess the mid-term outcome of the biological freestyle® prosthesis in combination with operations on the ascending aorta and the aortic arch with regard to prosthetic performance, reoperations, stroke and death.


Eligibility criteria:
inclusion criteria: * all patients after implantation of a biological medtronic freestyle root prosthesis in the time frame from november 2007 till april 2017 * elective, urgent and emergency operations on ascending aneurysms, aortic dissections, endocarditis and aortic root pathologies * combination of other procedures (coronary artery bypass grafting, operations on mitral and tricuspid valve, ablations) exclusion criteria: * refused patient consent

Keywords: hemiarch replacement cardiopulmonary bypass cannulation technique selective cerebral perfusion
a study to evaluate persistence of immunity of pcv13 in healthy population aged 2 months，7 months-5 years

Conditions: Pneumonia

Summary: the goal of this clinical trial is to learn about persistence of immunity of pcv13 in healthy population aged 2 months, 7 months-5 years. the main questions it aims to answer are the percentage of subjects reached the igg level of ≥0.35 µg/ml, gmcs level for igg antibody, and saes from one month to 12 months after the last injection.


Eligibility criteria:
inclusion criteria: * those who have participated in the phase iii clinical study of beijing minhai pcv13 and have been fully vaccinated with minhai pcv13; * an informed consent was required to sign by their legal guardians; * volunteers and their legal guardians/caregivers were able to attend the study visit as required by the protocol. exclusion criteria: * those who had any administration history of pneumococcal polysaccharide or conjugate vaccine after participating in the phase iii clinical study; * prior to enrollment, patients who had a history of pneumococcal infection with one or more of the well-defined pcv13 serotypes; * the researchers shall judge the other conditions which might be not in compliance with the requirements of this clinical trial.
epilepsy birth control registry

Conditions: Epilepsy

Summary: despite the importance of birth control to women of reproductive age, there has been little formal investigation of the safety and effectiveness of birth control methods in women with epilepsy. to remedy this, doctors from harvard and columbia university medical schools have developed a website that offers a survey to help us gain more knowledge and some educational material that will be updated regularly to provide the latest information. the ultimate goal is to develop guidelines for the selection of safe and effective birth control methods and to make sure that the best forms of birth control become available to women with epilepsy in all communities of our society. go to www.epilepsybirthcontrolregistry.com take our survey and then catch up on the latest information about birth control for women with epilepsy.


Eligibility criteria:
inclusion criteria: * women with epilepsy between 18 and 47 exclusion criteria: * women without epilepsy * women under 18 * women over 47

Keywords: epilepsy contraceptive birth control seizure this study is looking at the use of different birth control measures in women with epilepsy.
understanding health care information for african americans with high blood pressure

Conditions: Hypertension

Summary: this clinical trial focuses on helping african americans with high blood pressure to manage their disease. the study will target their ability to read and understand health information (also called health literacy). the research method relies on community participation in equal partnership with the researchers to provide interactive workshops and home blood pressure self-monitoring with the assistance of telephone counseling by community health workers.

the purpose of this study is to develop a culturally sensitive intervention focused on health literacy that is designed to reduce high blood pressure (hbp) in a vulnerable african american (aa) population. a community-based participatory research approach delivered by community health workers (chw) will be used to address the following specific aims: aim 1. to examine the effect of health literacy on self-care skills, including hbp knowledge, adherence to hbp and substance abuse treatment recommendations, communication skills, health care utilization, and bp outcomes in aas with hbp. aim 2. to conduct a pilot randomized, controlled trial with a delayed intervention control group to test the effectiveness of a health literacy-focused self-help hbp intervention program using chws in 100 aas who reside in baltimore city.

Eligibility criteria:
inclusion criteria: 1. self-identified as african american aged 18 years or older; 2. systolic bp \>140 and/or diastolic bp \>90 mmhg or sbp \>135 and/or dbp \>85 mmhg for individuals with diabetes mellitus or chronic kidney disease or on hbp medication; and 3. has a land-based telephone in the home or a cellular phone. exclusion criteria: 1. participation in another ongoing trial; 2. acute and/or terminal condition precluding participation, such as terminal cancer; 3. hospitalization for stroke, myocardial infarction, coronary artery vascularization in the past 3 months; 4. recipient of an organ transplant or on kidney dialysis; and 5. psychiatric diagnosis precluding participation, such as schizophrenia or cognitive impairment as measured by mini-mental state exam (score \< 24)

Keywords: african american high blood pressure
to compare the efficacy of nor adrenaline and terlipressin vs step up terlipressin therapy in hepatorenal syndrome

Conditions: Hepatorenal Syndrome

Summary: all consecutive patients with liver cirrhosis having acute kidney injury at admission or during hospitalization will be included in the study. the diagnosis of liver cirrhosis will be based on the clinical grounds including laboratory tests, endoscopic evidence, imaging (ultrasonography/computed tomography) findings, and liver histology, when available.


Eligibility criteria:
inclusion criteria: - patients with liver cirrhosis and acute kidney injury. patients consented for the study protocol by signing the informed consent. exclusion criteria: - age less than 18 years cirrhotics with kidney injury managed as outpatients. patients undergoing renal replacement therapy (hemodialysis/renal transplantation). post liver transplantation patients. hepatocellular carcinoma. history of coronary artery disease, ischaemic cardiomyopathy, ventricular arrhythmia, or peripheral vascular disease. patients with obstructive uropathy. patient who withdrew or non complaint to the study protocol.
the effect of remifentanil on established sunburn-induced hyperalgesia in human volunteers

Conditions: Hyperalgesia

Summary: treatment of chronic pain is a major clinical challenge since chronic pain is frequent and leads to deterioration of quality of life. an injury or wound can lead to long term changes in the nervous system that make the skin more sensitive at and near the injury; this is termed hyperalgesia and occurs through long term depotentiation (ltp), i.e., a change in the synaptic interaction between neurons. opioids are the gold standard for the symptomatic therapy of moderate to severe pain. now, in animal studies the investigators have discovered previously unrecognized effects of opioids. uv-b irradaition of the skin of the thigh is an established model of priamary and secondary hyperalgeisa in humans. the investigators want to test the influence of remifentanil, an ultra-short acting opioid, on hyperalgesia observed after uv-b irradiation in human volunteers in a double blind cross-over prospective active placebo controlled clinical trial.


Eligibility criteria:
inclusion criteria: * body mass index between 15th and 85th percentile * normal findings in the medical history and physical examination * drug free for 1 week prior to the study day exclusion criteria: * regular use of medication especially analgesics * abuse of alcoholic beverages, drug abuse * history of asthma * participation in a clinical trial in the 2 weeks preceding the study * symptoms of a clinically relevant illness in the 2 weeks before the first study day * resting systolic blood pressure \> 135 mmhg or diastolic blood pressure \> 85 mmhg * acute skin diseases like sunburn on the relevant areas or skin lesions * pregnancy or breast feeding * uv sensitive skin conditions, like xeroderma pigmentosa

Keywords: sunburn remifentanil hyperalgesia
effects of androgen administration on inflammation in normal women

Conditions: Hyperandrogenism

Summary: the hypothesis of this study is that dhea administration to increase male hormone in healthy normal-weight young women to levels present in women with polycystic ovary syndrome will cause an inflammatory response in white blood cells in the fasting state, and in response to glucose ingestion.


Eligibility criteria:
inclusion criteria: * acceptable health based on interview, medical history, physical examination and lab tests * ability to comply with requirements of the study * ability and willingness to provide signed, witnessed informed consent * between the ages of 18-40 years * body mass index between 18 and 25 * normal regular monthly periods * no clinical evidence of androgen excess * no evidence of polycystic ovaries on ultrasound exclusion criteria: * diabetes mellitus * clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious and malignant disease * high blood pressure * current or recent (within 30 days prior to study entry) use of any drugs known or suspected to affect reproductive function including oral contraceptives, metformin, gonadotropin releasing hormone agonists, or anti-androgens (spironolactone, flutamide, etc.) * use of medications that have an adverse drug interaction with dhea therapy including antipsychotics, phenothiazines, lithium, selective serotonin reuptake inhibitors, triazolam, estrogen or testosterone formulations * known hypersensitivity to dhea * two first-degree relatives with breast cancer or ovarian cancer * documented or suspected history of recent (within 1 year) illicit drug abuse or alcoholism * tobacco smoking * ingestion of any investigational drugs within 4 weeks prior to study onset * pregnancy or lactation (less than or equal to 6 weeks postpartum)

Keywords: hyperandrogenism inflammation insulin sensitivity body composition
managed access programs for inc424, ruxolitinib

Conditions: Primary Myelofibrosis (PMF); Post Polycythemia Myelofibrosis (PPV MF); Thrombocythemia Myelofibrosis (PET-MF); Severe/very Severe COVID-19 Illness; Polycythemia Vera (PV); Steroid Refractory Acute Graft Versus Host Disease (SR AGVHD); Steroid Refractory Chronic Graft Versus Host Disease (SR CGVHD)

Summary: the purpose of this registration is to list managed access programs (maps) related to inc424, ruxolitinib

cinc424a2405 - no longer available- managed access program (map) cohort treatment plan cinc424a2405 to provide access to ruxolitinib for patients with primary myelofibrosis (pmf) or post polycythemia myelofibrosis (ppv mf) or post-essential thrombocythemia myelofibrosis (pet-mf) cinc424a2001m - no longer available - ruxolitinib managed access program (map) for patients diagnosed with severe/very severe covid-19 illness cinc424b2002i - no longer available- managed access program (map) cohort treatment plan cinc424b2002i to provide access to ruxolitinib for patients with polycythemia vera (pv) cinc424c2001m - available - managed access program (map) cohort treatment plan cinc424c2001m to provide access to ruxolitinib for steroid refractory acute and chronic graft versus host disease (sr agvhd and sr cghvd).

Eligibility criteria:
inclusion criteria 1. an independent request was received from a licensed physician. 2. the patient has a serious or life-threatening disease or condition and there is no comparable or satisfactory alternative therapy available for diagnosis, monitoring, or treatment. 3. the patient is not eligible or able to enroll in a clinical trial or continue participation in such trial. 4. there is a potential patient benefit to justify the potential risk of the treatment use, and the potential risk is not unreasonable in the context of the disease or condition to be treated. 5. the patient must meet any other medical criteria established by the medical experts responsible for the product or by the health authority in the country of request (as applicable). 6. provision of the product will not interfere with the initiation, conduct, or completion of a novartis clinical trial or overall development program. 7. managed access provision is allowed per local laws/regulations.

Keywords: map manage access program primary myelofibrosis (pmf) post polycythemia myelofibrosis (ppv mf) thrombocythemia myelofibrosis (pet-mf) severe/very severe covid-19 illness polycythemia vera (pv) steroid refractory acute graft versus host disease (sr agvhd) steroid refractory chronic graft versus host disease (sr cgvhd) inc424 ruxolitinib
effect of gum chewing on bowel cleansing before colonoscopy

Conditions: Bowel Preparation Scale; Adenoma Detection Rate

Summary: in this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. group a patients (n = 150) used 2 l peg before colonoscopy. patients in group b (n = 150) were additionally advised to chew sugarless gum plus 2 l peg, the overall quality of colonoscopy cleaning was evaluated using the boston bowel preparation scale by endoscopists who was blinded to the intervention. difficulty of procedure, patients' tolerance, and adverse events were also evaluated.


Eligibility criteria:
inclusion criteria: * all adults (18-65) who were referred for outpatient colonoscopy. exclusion criteria: * under 18 years or more than 65 years * previous abdominal surgery * major psychiatric disorders * pregnancy * presence of any contraindications for colonoscopy(eg, severe heart failure) * recent inadequate colonoscopy history