Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of dual therapy for helicobacter pylori eradication

Conditions: Helicobacter Pylori Infection

Summary: the purpose of this study was to evaluate the efficacy and safety of vonoprazan- amoxicillin dual therapy for helicobacter pylori eradication

this study intends to select the patients with hp infection in 11 tertiary hospitals across our country, and randomly give the two therapies to compare the eradication rate, compliance, the rate of adverse events, so as to provide some advices for the selection of appropriate eradication therapy, then collect an efficient, convenient and safe therapy for patients with h.pylori infection. before receiving the treatment plan, general information and relevant medical history of the subjects were collected through electronic questionnaires.the experimental data will be collected and recorded through follow-up by phone or wechat during the experiment.

Eligibility criteria:
inclusion criteria: 1. ages between 18 and 65 years; sexes eligible for study: both; 2. patients who are diagnosed with helicobacter pylori; 3. treatment-naive patients or patients who failed to eradicate helicobacter pylori in the past but haven't undergone eradication therapy in the past six months; 4. voluntary to be involved in the study and written informed consent was obtained from all patients exclusion criteria: 1. allergic reactions to the study drugs; 2. patients with peptic ulcer; 3. patients who underwent eradication therapy for helicobacter pylori during the last six months; 4. patients who took antibiotics,bismuth agents,probiotics within four weeks prior to treatment and those who took h2 receptor antagonists,proton pump inhibitors(ppis) or potassium competitive acid blockers within two weeks prior to treatment; 5. patients who are taking glucocorticoids, non-steroidal anti-inflammatory drugs or anticoagulants; 6. patients who have history of esophageal or gastric surgery; 7. pregnant or lactating women; 8. patients who have severe concurrent diseases such as hepatic,cardiovascular,respiratory,renal disorders or malignancies; 9. alcohol abusers

Keywords: helicobacter pylori dual therapy infection eradication safety
ovicidal efficacy and safety of abametapir lotion 0.74% administered for the treatment of head lice infestation

Conditions: Head Lice Infestation

Summary: the purpose of the study was to evaluate ovicidal efficacy of a single application of abametapir lotion 0.74% w/w intended for the treatment of head lice.

this was a double-blind, randomised, vehicle-controlled, parallel group study in males and females, aged three years and older with active head lice infestation. the study was designed to assess the ovicidal efficacy of a single application of abametapir lotion 0.74% w/w compared to a vehicle control, when applied to the scalp and hair for 10 minutes at the study site. this study used an ex vivo method of assessment for ovicidal efficacy.

Eligibility criteria:
inclusion criteria: 1. healthy male or female based on medical history 2. six months of age or older. 3. has an active head lice infestation with a minimum of 3 live head lice and at least 10 undamaged and unhatched head lice eggs in their hair. 4. agrees to an examination for head lice and compliance with the study procedures. 5. all adult subjects must sign a written voluntary informed consent. for minors, the parent/ legal guardian agrees to the subject participating in the study as determined by the signing of an assent of informed consent. exclusion criteria: 1. has scalp disease or a history of allergies or prior reactions to any head lice products. 2. has a condition that, in the opinion of the investigator, may interfere with the study. 3. is receiving systemic or topical medication, which in the opinion of the investigator, may compromise the integrity of the safety and/or efficacy assessments. 4. had treatment (over-the-counter (otc) or home remedy medication) for head lice within 14 days prior to day 0. 5. has received an investigational agent within 30 days prior to day 0.
impact of combined aerobic and resistance exercise on autonomic function and cardiopulmonary endurance in obese college students

Conditions: Obese College Students; Aerobic Exercise Combined with Resistance Exercise

Summary: this study explores the potential link between aerobic exercise combined with resistance training and improvements in cardiopulmonary function in obese individuals, focusing particularly on the influence of autonomic nerve function. by examining the effects of combined exercise on obese college students, this research aims to elucidate the critical role that autonomic nerve function improvement plays in enhancing cardiopulmonary function in this demographic. the study primarily utilized a combined exercise regimen of aerobic and resistance exercises, conducted three times a week over a period of 16 weeks. one session was held during class hours, with the remaining two sessions scheduled during free time in the university gym. aerobic exercises included the use of treadmills and elliptical machines, with intensity maintained at 60%-70% of the maximum heart rate (calculated as 220 minus age), for a total of 40 minutes per session (5 minutes of warm-up, 30 minutes of main exercise, and 5 minutes of cool-down). heart rate monitors were used to ensure the intensity was maintained; resistance exercises involved gym equipment and bodyweight exercises, including the use of a pec deck machine, lat pull-downs, chest presses, bicep curls, tricep extensions, leg curls, and leg presses. the intensity of resistance exercises was set at about 65%-70% of one repetition maximum (1rm), with each session consisting of three sets of 6-8 repetitions and lasting for 30 minutes.


Eligibility criteria:
inclusion criteria: * obese college students aged 18-22 were recruited from a university in beijing to participate in a public elective course on exercise for weight loss and slimming at the capital university of physical education and sport (cupes). the inclusion criteria included a bmi of ≥28 kg/m\^2, no history of chronic diseases such as cardiovascular or metabolic diseases, no psychiatric conditions (e.g., depression, anxiety disorder, obsessive-compulsive disorder), and no physical disabilities or movement disorders (such as bone and joint diseases). exclusion criteria: * the exclusion criteria include individuals with diseases that may affect training (such as cardiovascular diseases, respiratory diseases, and musculoskeletal disorders), as well as those diagnosed with mental disorders (such as depression, anxiety, obsessive-compulsive disorder, etc.).

Keywords: aerobic exercise combined with resistance exercises cardiorespiratory endurance autonomic function obese college students
end-of-life patient identification assistance in acute geriatric medicine

Conditions: Old Age

Summary: the main objective of this project is to build a tool, adapted to the french geriatric population, that will predict the risk of death at three months after hospitalization in acute geriatric medicine. this tool will be built using selected items via a review of the literature published in 2015. the 8 items of the cristal tool will be collected prospectively in all patients hospitalized successively in the 2 post-emergency geriatric services (pug) of the university hospital of toulouse, over a period of 9 months, by a dedicated clinical research associate. patient survival will be assessed by obtaining the vital status of the cohort via cépidc

as the population ages, the prevalence of chronic diseases increases. let's take the example of cardiovascular, respiratory or neurological diseases, including alzheimer's disease. these pathologies are at the origin of decompensations requiring sometimes multiple hospitalizations. it is clear that the goals of care (curative or palliative) are not always related to life expectancy. decision making, especially in an acute context, is often tricky. the use of a tool with certain parameters of the patient could help to guide the reflection. the present study propose a tool proposed by an australian team (cristal), which lists items described in the literature as a risk factor for the death of elderly patients. this tool is currently being studied in several types of populations around the world (general population, cancer patients, hospitalized etc.). this is a prospective study aimed at evaluating routine, single-center care, conducted at toulouse university hospital. the successive inclusion of hospitalized patients in post emergencies geriatric (pug) unity will be carried out over a period of 9 months. the primary outcome will be the vital status (alive / deceased) at 3 months of hospitalization in acute geriatric medicine.

Eligibility criteria:
inclusion criteria: * any geriatric patient hospitalized via emergencies at post emergencies geriatric (pug) unity * oral agreement of non-opposition to the use of the data relative to their hospitalization and relative to their evolution within 3 months following the hospitalization exclusion criteria: * patient having expressed his opposition to the use of data related to his hospitalization

Keywords: end of life spotting emergency cristal
role of faecal calprotectin in patients with abdominal pain

Conditions: Inflammation

Summary: the evaluation of patients with abdominal pain is a challenge for the emergency physician and the selection of patients for second-level radiological examinations or endoscopic procedures is not always easy to perform. faecal calprotectin could be a useful diagnostic marker to distinguish between "organic" or "functional" form and its determination could be helpful to select patients for further examinations, in the context of emergency setting.


Eligibility criteria:
inclusion criteria: * patients with abdominal pain and/or diarrhea and/or rectal bleeding exclusion criteria: * patients with age \< 18 years * pregnant women; * patients with oncological, cardiological, nephrological terminal diseases; * patients on antibiotic therapy or who have taken it during the last month; * patients with a history of colic resection or gastrointestinal surgery; * patients with a previous diagnosis of inflammatory bowel disease (crohn's disease, ulcerative colitis)
clinical study of anti-tumor necrosis factor therapy in patients with takayasu arteritis

Conditions: Takayasu's Arteritis

Summary: clinical study of anti-tumor necrosis factor therapy in patients with takayasu arteritis. this study is single arm (anti tumor necrosis factor therapy only) clinical trial. enrolled patients will be 11

clinical study of anti-tumor necrosis factor therapy in patients with takayasu arteritis. this study is single arm (anti tumor necrosis factor therapy only) clinical trial. enrolled patients will be 11 patients with active takayasu's arteritis

Eligibility criteria:
inclusion criteria: * active takayasu's arteritis exclusion criteria: * active tuberculosis * liver function abnormality * heart failure ( new york heart association iii - iv) * patients were not consented
predicting pathological complete response of rectal cancer with magnetic resonance(mr) radiomics

Conditions: Locally Advanced Rectal Cancer

Summary: this study plans to construct a mr radiomics model for predicting pathological complete response(pcr) to neoadjuvant chemoradiotherapy(crt) in locally advanced rectal cancer(larc) patients.

we propose to develop and validate a radiomics model for individualized pcr evaluation after crt in patients with larc. we plan to use both pre- and post-crt mri data to construct the predictive radiomics model for evaluating if larc patients achieve pcr after crt. the ultimate aim is to select appropriate larc patients for omission of surgery.

Eligibility criteria:
inclusion criteria: * pathologically proved rectal cancer * locally advanced rectal cancer (≥t3 or n+) * a distance less than 12cm between the lower edge of tumor and the anal margin * no evidence of distant metastases * no prior anti-cancer therapy before treatment * scheduled to receive preoperative crt exclusion criteria: * history or concurrent of other malignancy * incomplete preoperative crt * failed to receive surgery or unavailable pcr assessment * poor quality of mr images for measurement * patient quit
a trial of ak117 (anti-cd47 antibody) in patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: this is a open label, phase ib/ii study. all patients are diagnosed with aml, eastern cooperative oncology group (ecog) performance status 0-3. the purpose of this study is to evaluate the safety and efficacy of ak117 + azacitidine in subjects with aml.


Eligibility criteria:
inclusion criteria: * age ≥18 years (at the time consent is obtained). * be able and willing to provide written informed consent and to comply with all requirements of study participation (including all study procedures). * has an eastern cooperative oncology group (ecog) performance status of 0 - 3，and 0\~2 are required for subjects ≥75 years old. * has a life expectancy of at least 12 weeks. * patient with aml diagnosed according to who 2016 criteria. * has adequate organ function. * all female and male subjects of reproductive potential must agree to use an effective method of contraception, as determined by the investigator, during and for 120 days after the last dose of study treatment. exclusion criteria: * patient has acute promyelocytic leukemia. * patient has known active central nervous system (cns) involvement with aml. * favorable risk cytogenetics such as t(8;21), inv(16) or t(16;16) or t(15;17) as per the national comprehensive cancer network (nccn) guidelines version 2, 2021 for aml. * is currently participating in a study of an investigational agent or using an investigational device. * has undergone major surgery within 30 days of study day 1. * has a known additional malignancy that is progressing or requires systemic treatment. exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer. * previous allogeneic hematopoietic stem cell transplant (allo-hsct) . * prior treatment with any anti-cd47 or anti-sirpα (signal regulatory protein alpha) agent. * has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). replacement therapy (e.g., thyroxine, insulin or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. * has known active hepatitis b (e.g., hbsag reactive) or hepatitis c (e.g., hcv rna \[qualitative\] is detected). * has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of this subject to participate, in the opinion of the treating investigator. * has received a live virus vaccine within 30 days of the planned first dose of study therapy. * is pregnant, breastfeeding, or expecting to conceive or father a child within the projected duration of the study including 120 days following the last dose of study treatment. * patient with known allergy or hypersensitivity to ak117, azacitidine or any of their components.
the effect of high intensity laser therapy in the management of painful calcaneal spur

Conditions: Calcaneal Spur

Summary: the effect of high intensity laser therapy in the management of painful calcaneal spur: a double blind, placebo-controlled study

the objective of this study was to evaluate the effect of high-intensity laser therapy (hilt) and exercise in patients with calcaneal spur. the patients were randomly assigned to receive either hilt + exercise (n=21) or placebo hilt + exercise (n=21). pain severity (with visual analog scale (vas) and with roles and maudsley score (rms) ), functionality (with foot and ankle outcome score (faos)), plantar pressure measurement (with pedobarographic assesment), and quality of life (with short form-36 (sf-36)) of the patients were evaluated at baseline, at 4 weeks, and 12 weeks.

Eligibility criteria:
inclusion criteria: * eligible patients aged 30-75 years old with pain in the plantar region lasting for at least one month, who were sensitive to palpation and who were diagnosed with a calcaneal spur in the subcalcaneal region as shown in a lateral x-ray of the foot were included in the study. exclusion criteria: * patients with any sign of pathology in the blood count, with an increased sedimentation rate, having undergone any physical therapy for calcaneal spur within the past six months and/or local anesthesia and/or steroid injection in the region of pain, with the presence of a pathology on the x-ray apart from calcaneal spur, pregnancy, with the presence of systemic inflammatory disease, and with a history of local trauma or a history previous hilt therapy were excluded from the study

Keywords: hilt calcaneal spur placebo
tick-borne illness and clothing study of rhode island

Conditions: Tick Bites; Tick-borne Diseases

Summary: lyme and other tick-borne diseases pose a significant health threat to outdoor workers. this study is a double-blind randomized controlled trial of outdoor workers in rhode island and the surrounding area that will address the following study aims: 1) evaluate the effectiveness of llpi clothing in preventing tick bites among outdoor workers in lyme endemic areas; 2) measure the urine levels of permethrin metabolites in study subjects; and 3) measure the loss over time of knockdown activity against ticks and of permethrin in llpi clothing.

lyme and other tick-borne diseases pose a significant health threat to outdoor workers. in a double-blind randomized controlled trial (rct) in north carolina outdoor workers, the investigators previously showed that long-lasting permethrin-impregnated (llpi) clothing provided \>80% protection for one year against lone star tick bites among outdoor workers in north carolina. but there are three issues that need to be addressed before this finding can be translated into policy: 1) do llpi clothing protect against black legged ticks, the vector for lyme disease, babesiosis and anaplasmosis? 2) what levels of permethrin and its metabolites are absorbed, and are they potentially toxic? 3) why did the llpi clothing in our previous study lose efficacy after a year? participants: the investigators will recruit 250 outdoor workers. the investigators anticipate recruiting 80, 80, 40,30, and 20 participants from nationalgrid, the ri department of environmental management, the massachusetts department of conservation \& recreation, the national park service, and the us fish \& wildlife service. procedures (methods): this will be a randomized controlled trial. all study subjects will fill out weekly tick logs, collect attached ticks for later speciation and pathogen detection, and submit annual serum samples to test for exposure to tick-borne pathogens. a randomly selected subset of 60 subjects also will be asked to submit urine samples for permethrin metabolite analysis at several time points during follow-up. an additional randomly selected subset (n=30) will be asked to submit worn items of clothing for tick knockdown testing and permethrin content analysis at the end of the first and second years of field testing. the results of this study could help protect hundreds of thousands of outdoor workers with exposure to ticks and tick-borne pathogens.

Eligibility criteria:
inclusion criteria: * over 18 years of age, * spending an average of 10 or more hours of outdoor work per week during peak tick season, and * completion of written informed consent. exclusion criteria: * pregnancy or a planned pregnancy during the follow-up period (since exposure to an insecticide is involved), * non-english speakers, or * having a known allergy or sensitivity to insecticides
acceptability and tolerability of ketone supplements and effects of bhb concentrations in young adults

Conditions: Exogenous Ketosis

Summary: assess the acceptability and tolerability of two different commercially available ketone supplements and determine their effects on capillary blood concentrations of the ketone beta-hydroxybutyrate and glucose in young adults.

past findings suggest that raising ketone concentrations through the use of a ketogenic diet (high-fat, moderate-protein, low-carbohydrate) is effective for preventing weight gain and decreasing appetite. however, strict adherence to this diet is difficult, and ending the diet can result in the regaining of body weight. our group has investigated the effects of various ketone supplements in both rodents and humans. past results of our group and that of our colleagues suggest that ketone supplements have the ability to increase ketone concentrations in the blood, decrease appetite, lower body weight, and maintain lean body mass. exogenous ketones may serve as an alternative to the ketogenic diet by increasing concentrations of ketones without the need for adherence to a strict diet. however, little is known about ketone supplements as it relates to their tolerability and efficacy. for example, the taste of these supplements is unacceptable to some individuals and it is unclear if ketone supplements provide an adequate approach to raise and maintain circulating ketone concentrations as observed with the ketogenic diet. this information will be valuable before launching larger-scale human trials. ketone supplements (ke1 and ke4) will be obtained from ketoneaid (falls church, va). participants will be asked to drink (5g and 10g) of each supplement separated by at least 3 days. capillary blood samples will be measured using a handheld device to measure circulating beta-hydroxybutyrate (bhb) and glucose concentrations while a questionnaire will be used to assess the acceptability and tolerability of the ketone supplements.

Eligibility criteria:
inclusion criteria: * adult 18-25 years of age * in generally good health * able and willing to attend study visits (once every 3 days for \~2 weeks) * bmi 18.5-29.9 exclusion criteria: * pregnant * has preexisting medical conditions, including type 2 diabetes, heart disease, or cancer * bmi ≥ 30

Keywords: exogenous ketones ketone supplementation ketone monoester ketone salt tolerability acceptability beta-hydroxybutyrate