Kornimate/medical-research-clean huggingface dataset:
decision impact study of precisedx breast

Conditions: Breast Cancer

Summary: the investigator's developed a digital ldt to predict invasive breast cancer (ibc) recurrence within 6 years by combining histologic features extracted from an h\&e image of the patients ibc with clinical data including the patients age, tumor size, stage and number of positive lymph nodes. the development of an artificial-intelligent (ai)-grade provides not only an objective, quantitative advancement of classical breast cancer grading but also improves upon the accuracy and utility of clinical risk. the investigator's sought to understand how such a precisedx breast would be used in clinical practice post-surgical resection for women with early-stage ibc.

female breast cancer (bc) has surpassed lung cancer as the most commonly diagnosed cancer worldwide, which translates into 24.5% of all cancer diagnoses and 15.5% of all cancer death. in the united states, it is estimated that 290,560 americans will be diagnosed with breast cancer in 2022 and 43,780 will die of disease. given these statistics, the 2022 national comprehensive cancer network (nccn), american society of clinical oncology (asco), and college of american pathologists (cap) clinical practice guidelines continue to stress the critical importance of the pathology assessment at diagnosis to establish extent of disease and features that reflect a biological potential for recurrence such as histologic grade and stage. precise dx breast assay (pdxbr™) is an in vitro prognostic clinically approved test by the nysdoh to predict breast cancer recurrence for patients diagnosed with early-stage ibc. the test utilizes a digital scan of a representative h\&e-stained resection specimen from the patient. using advances in applied artificial intelligence (ai) outcome-based image analysis, selected features of the invasive cancer are acquired and combined with clinical variables to produce a risk score predicting likelihood of having breast cancer recurrence within 6-years. with the advent of computational methods, the investigator's investigated whether ai interrogation of whole slide images (wsi) could be used to improve on the characterization and accuracy of ibc histopathology. the approach was based on the generation of quantitative, discreet morphology features within a tissue section (morphology feature array, mfa) and the use of machine learning to create ai models that predict risk of recurrence in early-stage disease. the investigator's developed a test that improves risk stratification of ibc relative to the use of clinical features as well as re-classification of standard breast histologic grade into low- and high-risk groups using mfa-enabled ai models.

Eligibility criteria:
inclusion criteria: * invasive breast cancer (ductal / mixed ductal-lobular) exclusion criteria: * prior history of invasive breast cancer * neoadjuvant therapy
telehealth group counseling and preventive care for women

Conditions: ASCVD; NSTEMI; STEMI; Coronary Artery Disease; Acute Coronary Syndrome; Myocardial Infarction; Unstable Angina; Chest Pain

Summary: the purpose of this study is to utilize an innovative healthcare delivery strategy via telehealth group counseling sessions to improve engagement, adherence, and ultimately outcomes in female patients with atherosclerotic cardiovascular disease (ascvd).

this will be an electronic survey study of female patients with known atherosclerotic cardiovascular disease (ascvd) who are managed by providers in the weill cornell medicine cardiology division and self-select into this telehealth group education series. group health counseling will be administered via the weill cornell medicine approved telehealth platform at the time of participation. participants will have the option to choose the session topic of their choice and will have the opportunity to participate in 1-5 sessions over 12 weeks, depending on their preference. each session will occur regardless of number of participants but will be capped at 12 participants, anticipating that two will not join. once consent is obtained, baseline characteristics of participants will be collected via chart review. demographics such as age, race, insurance carrier, and clinician-documented diagnoses, such as ascvd, hypertension (htn), hyperlipidemia (hld), and diabetes mellitus (dm), will be collected. prior to each group health counseling session, an initial survey will be provided to patients who are chosen for and consent to this study. this survey will ask patients about their demographics, self-reported diagnoses, current level of satisfaction about their understanding of their diagnoses, reasons for participating in the study, and history of previous participation in telehealth group counseling. after the sessions, a post-session survey will be provided to all participants and will assess patient understanding, including diagnoses and medications, satisfaction with the format, satisfaction with the provider, how many sessions were attended, reasons for attending more than one session, and recommendation of this format to others. all data will be de-identified prior to analysis and will remain confidential among investigators.

Eligibility criteria:
inclusion criteria: * female patients * age 18 and older * patients who are managed by providers at the weill cornell medicine women's heart program * women with evidence of atherosclerotic cardiovascular disease (ascvd) and diagnoses of chest pain, myocardial infarction/heart attack (myocardial infarction - non st elevation nstemi, st elevation stemi), coronary artery disease, acute coronary syndrome, unstable angina, atherosclerotic cardiovascular disease, hypertension (htn), hyperlipidemia (hld), diabetes (dm), and/or palpitations (as confirmed by clinician referral to study and chart review) exclusion criteria: • women with risk factors (ex: htn, hld, dm) but no evidence of ascvd

Keywords: ascvd nstemi stemi coronary artery disease acs myocardial infarction unstable angina chest pain
definition of autonomic nervous system involvement in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the goal of this interventional non-pharmacological study is to evaluate the involvement of the autonomic nervous system in patients with relapsing-remitting and primary progressive multiple sclerosis. the main questions it aims to answer are: * is it possible to define the characteristics of dysautonomia to improve treatment on patients with multiple sclerosis through the management of conditions such as orthostatic hypotension or thermoregulation disorders that inevitably condition the patient's life and the response to rehabilitation ? * does the severity of the functional alterations correlate with impairment of small somatic and autonomic cutaneous nerve fibers in patients with multiple sclerosis ? * how much the involvement of the autonomic nervous system affects the clinical history and progression of the disease ? * do different clinical variants of multiple sclerosis manifest with different patterns of involvement of the sensory-autonomic nervous system ? participants will be hospitalized in maugeri clinical institute of telese terme for a rehabilitation treatment. patients will perform a sensory and autonomic functional study and a morphological analysis of cutaneous nerves through skin biopsy. researchers will compare results between the two groups (relapsing-remitting and primary progressive) and between patients and data from control subjects.


Eligibility criteria:
inclusion criteria: * diagnosis of relapsing-remitting and primary progressive multiple sclerosis. exclusion criteria: * other forms of multiple sclerosis, * known other neurological disorders * assumption of potentially neurotoxic substances or drugs.

Keywords: autonomic nervous system sensory nervous system rehabilitation skin biopsy
sevelamer hydrochloride and femoral and carotid intima media thickness progression in end stage renal disease

Conditions: End Stage Renal Disease; Hemodialysis; Intimal Media Thickness

Summary: aims of the multi-center, randomized, treatment-controlled clinical trial are to compare the efficacy of sevelamer hydrochloride to calcium-containing phosphorus binders in reducing the rate of progression of femoral and carotid intimal media thickness (imt) thickening as measured by b-mode ultrasound in stable maintenance hemodialysis (hd) patients.

serum phosphorus (p) is frequently elevated in hd patients. serum p stimulates pth synthesis and is associated with secondary hyperparathyroidism. use of calcium(ca)-containing phosphorus-binders is an exogenous source of ca that can elevate the caxp product. in hd patients, an ultrasonographically-demonstrated increase in intima media thickness of the carotid artery has been associated with elevated serum p levels.peripheral arterial vascular disease (pvd) accounts for significant mortality and morbidity in hd patients. the aim of this study is to compare the efficacy of sevelamer hydrochloride to calcium-containing phosphorus binders in reducing the rate of progression of femoral and carotid intimal media thickness (imt) thickening as measured by b-mode ultrasound in stable hd patients. subject randomization numbers was provided by the epidemiology and research unit, e. wolfson medical center, holon, israel. after meeting all inclusion criteria, subjects were randomized to one of two treatment groups: renagel or calcium carbonate. prior to receiving treatment, baseline femoral and carotid imt were measured, medical and pharmaceutical history was documented, nutrition assessment was undertaken and midweek blood chemistry and blood count were measured. no change in patient medication prescription was required during this study, with the exception of phosphorus binders. all other concomitant medications were continued. during the year of the study, routine monthly blood tests were obtained for chemistry, blood count, and pth was measured once every 4 months. after a year of treatment, femoral and carotid imt were measured again, midweek blood chemistry and blood count were measured.

Eligibility criteria:
inclusion criteria: * hd patients aged 40-75 years inclusive if they received hd treatment three times each week for not less than three months, and if they had not been treated with sevelamer hydrochloride. patients of both genders, without regard to diabetes status, history of cvd or underlying renal disease were eligible. exclusion criteria: * patients receiving treatment with sevelamer hydrochloride were not eligible for study participation. additionally, patients were excluded if they had active liver disease, known sensitivity to either sevelamer hydrochloride or calcum carbonate or if their participation in the study was deemed in any way detrimental or unwarranted by the patient's treating physician.

Keywords: hemodialysis intimal media thickness
neurophysiological and immunological effects of the transition from combustible to electronic cigarettes

Conditions: Tobacco Smoking; Nicotine Dependence

Summary: the objective of this study is to examine the cognitive, immunological, and neurophysiological effects of transitioning from tobacco cigarettes to electronic cigarettes. the central hypothesis of this study is that this transition will be accompanied by a decrease in peripheral inflammation, which will lead to significant changes in the neurocircuitry underlying interoception and appetite.

participants who are current cigarette smokers will be randomly assigned to either the experimental or control groups. following a baseline psychiatric assessment session, subjects will return to the study center for two to three additional follow-up visits. during the second visit, all subjects will undergo a functional magnetic resonance imaging (fmri) scanning session, during which they will perform a series of functional neuroimaging tasks designed to examine the neural substrates involved in visceral interoception and eating behavior. prior to the start of the scan session, blood samples will be collected from each subject, for the measurement of bio-markers related to nicotine use and peripheral inflammation. after the end of the second visit, subjects within the experimental group will be asked to switch from combustible to electronic cigarettes. subjects within the control group will continue to smoke combustible cigarettes as previously. during the third visit, which will follow two to eight weeks after the second visit, all subjects will provide a second blood sample and complete a second fmri scan session. both groups of participants will complete the same fmri tasks as they did during the second visit.

Eligibility criteria:
inclusion criteria: * current cigarette smokers who have smoked for at least one year * right-handed adults * able to provide written informed consent exclusion criteria: * use of anticonvulsant, stimulant, or antipsychotic medication for 3 weeks prior to scanning * any medical conditions or medications likely to influence cerebral blood flow or neurological function including cardiovascular, respiratory, endocrine and neurological diseases * any history of drug (other than nicotine) or alcohol abuse within 1 year * current pregnancy or breast feeding * primary language other than english * meeting general mri exclusion criteria such as magnetic implants or claustrophobia * past history of any axis i psychiatric condition, other than major depressive disorder and post-traumatic stress disorder * current major depression or post-traumatic stress disorder * serious suicidal ideation

Keywords: electronic cigarette
evaluation of anti-neutrophil cytoplasm antibodies test

Conditions: Immunological Testing in Small-vessel Vasculitis

Summary: anti-neutrophil cytoplasm antibodies (anca) are defined as important serological markers for the diagnosis of some forms of small vessel vasculitis, including granulomatosis with polyangiitis (gpa) , microscopic polyangiitis(mpa) and to a lesser extent churg -strauss syndrome or eosinophilic granulomatosis with polyangiitis (egpa).so they are called anca-associated vasculitis(aav). an international consensus statement for anca testing statement was issued in 2017 and states that the antigen specific immunoassays can be used for the accurate diagnosis of anca-associated vasculitis without the need for indirect immunofluorescence(iif). in the present study we will test whether the antigen specific assays screening is a valuable alternative to iif confirming with immunoassay for the diagnosis of aav on a number of patients and controls. aim to evaluate the performance of the recommended strategy for the detection of anca based on screening with antigen specific immunoassays on a number of aav patients and relevant disease controls in kagawa university hospital (rheumatology department). patients and methods this is a prospective study will be conducted at the department of rheumatology in kagawa university hospital in which consecutive samples will be included from patients suspected to have aav; patients subsequently identified as having aav will be included as aav patients, while patients in which the diagnosis aav is rejected, will be included as disease controls. pr3-and mpo-anca will be performed using assays from medical \& biological laboratories co (anchor cleia) isayama.takuya@mbl.co.jp

to evaluate the performance of the recommended strategy for the detection of anca based on screening with antigen specific immunoassays on a number of aav patients and relevant disease controls (i. e., patients for whom anca would be requested in the context of small-vessel vasculitis such as patients with infections, drug-induced diseases, connective tissue disease, etc.).

Eligibility criteria:
inclusion criteria: .all patients included must be older than 18 years and able to give informed consent. * classification criteria and nomenclature for aav are from the american college of rheumatology * serum sampling should be done before initiation of immunosuppressive treatment or no later than 2 weeks after onset of low-medium dose of immunosuppressive treatment (but this should be documented) exclusion criteria: .patients younger than 18 years old

Keywords: anca vasculitis, anca testing, antigen specific essays, iif
ulmus macrocarpa hance extract and lipid profile

Conditions: Dyslipidemias

Summary: the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the ulmus macrocarpa hance extract on lipid profile in adults with dyslipidemia for 12 weeks.

previous another our study have indicated that ulmus macrocarpa hance extract (umh) may have the ability to decrease blood cholesterol. therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the umh on lipid profile in adults with dyslipidemia; the safety of the compound are also evaluate. the investigators examine total cholesterol, hdl-cholesterol, triglyceridemia, ldl-cholesterol, and other biochemical parameters at baseline, as well as after 6 and 12 weeks of intervention. eighty adults were administered either 500 mg of umh or a placebo each day for 12 weeks;

Eligibility criteria:
inclusion criteria: * ldl cholesterol ranging from 130 to 190 mg/dl exclusion criteria: * abnormal liver or renal function (i.e., serum aminotransferase activity \> 80 iu/l and serum creatinine concentrations \> 1.2 mg/dl) * diabetes (diagnosed clinically or fasting glucose level \> 126 mg/dl) * history of ischemic heart disease or cerebrovascular disease * uncontrolled hypertension * history of serious cardiac disease such as angina or myocardial infarction * history of gastrectomy * history of medication for psychiatric disease * administration of oriental medicine including herbs within the past 4 weeks
gabapentin pretreatment for staged bilateral cataract operations

Conditions: Hyperalgesia; Cataract Bilateral Nos

Summary: to evaluate the effect of oral gabapentin premedication on hyperalgesia in elderly patients undergoing staged bilateral cataract operations under monitored anesthesia care

it has been reported that patients with bilateral cataract complained more pain and discomfort during the second consecutive eye surgery compared to the first eye surgery. gabapentin is an anticonvulsant drug, which has been extended the use to perioperative analgesia, and anxiolysis. therefore, the investigators conducted this randomized, controlled study to evaluate the effects of gabapentin premedication on patients' subjective sensations, including intraoperative anxiety, perceptions of pain, and light sensitivity, in the second cataract operations.

Eligibility criteria:
inclusion criteria: * patients aged over 60 years, who undergoing staged bilateral cataract operations under monitored anesthesia care * asa physical status of i, ii, and iii exclusion criteria: * undergoing other eye operations together besides cataract operation * patients with creatinin clearance lower than 30ml/min * patients with cns inhibitors medication * patients with previous gabapentin medication * pregnancy
the effect of smartphone and hand anthropometry on pain and upper extremity functions

Conditions: Upper Extremity Problem; Smartphone Addiction

Summary: mobile phones have different uses in different disciplines, and this encourages long-term use. for optimum comfort use, it is important to ensure users' awareness when purchasing mobile phones that match their hand sizes. the number of studies in the literature on this subject is limited. in this context, the aim of our study is to investigate the relationship between smartphone and hand anthropometry measurements and upper extremity pain and functions.

phone design features cause different problems on body mechanics and musculoskeletal system. with the use of smartphones, people tend to maintain incorrect postures for long periods of time, which increases tension in the body. this situation causes complaints such as cervical disc herniation, tingling complaints in different body parts, overuse injuries, upper crosses syndrome, and carpal tunnel syndrome. on the other hand, the use of smartphones is increasing among students for reasons such as providing students with freedom of time and space, increasing the speed of teaching and learning, supporting one-on-one learning, and increasing the number of ideas produced by encouraging a group discussion environment. mobile phones have different uses in different disciplines, and this encourages long-term use. although many musculoskeletal system structures can be affected by incorrect postures due to the long-term use of smart mobile phones, it is thought that the upper extremity is most affected. therefore, the aim of our study is to investigate the relationship between smartphone dimensions and hand anthropometric measurements and upper extremity pain and functions in order to raise awareness when purchasing mobile phones that match users' hand sizes for optimum comfort and use.

Eligibility criteria:
inclusion criteria: * sending at least 5 e-mails or text messages a day from your mobile phone, * using a smartphone for more than 1 hour a day to play games or browse the internet exclusion criteria: * having an existing injury in the hand or upper extremity (suffered 6 months ago) * having been diagnosed with a degenerative, inflammatory, musculoskeletal, neuromuscular, or congenital disorder of the hand or upper extremity.

Keywords: anthropometric measurements upper extremity smartphone
dysbiosis and immune reconstitution after allo-hsct

Conditions: Hematopoietic Stem Cell Transplantation

Summary: preliminary (proof of concept), monocentric, interventional, prospective, non-randomized and analytic trial designed to simultaneously explore intestinal microbiota changes and early post-transplant immune reconstitution, and to correlate biological data with clinical data (antibiotics use, stress level, gvhd).

allogeneic hematopoietic stem cell transplantation (allo-hsct) is the major curative therapeutic approach for hematologic neoplasms. after hsct, patients have a compromised gi mucosal barrier and an altered microbiota, also called dysbiosis. the later could be due to conditioning or use of broad-spectrum antibiotics, and could be accentuate by stress encountered by patients during their therapy management. recent data have shown that alterations in the intestinal flora are associated with bad outcome, particularly with graft-versus-host disease (gvhd), bacteremia, and reduced overall survival post-transplantation. how intestinal bacteria can modulate the risk of relapse after hsct is yet unknown. the scientists hypothesize that the variation of some bacterial taxa may influence post-transplant immune reconstitution, particularly invariant natural killer t cells.

Eligibility criteria:
inclusion criteria: * patients \> 18 years affiliated to a social security system * patients followed at the hospital of nancy for a allogeneic hematopoietic cell transplantation (hla matched donor) * graft of peripheral blood stem cell * gvhd prophylaxis by ciclosporin and antilymphocyte serum +/- mycophenolate mofetil or methotrexate. exclusion criteria: * hiv+ patients * patients with active hbv or hcv

Keywords: hsct intestinal dysbiosis immune reconstitution