Kornimate/medical-research-clean huggingface dataset:
withdrawal time and use of wide-angle endoscope to increase the adenoma detection rate of screening colonoscopy

Conditions: ColoRectal Cancer; Colon Polyp

Summary: colonoscopy outcome is strictly related to the adenoma detection rate (adr). an endoscopy withdrawal time \>6min has been suggested to increase the adr since it allows for thorough evaluation of the several hidden areas of the colon. the fuse, full spectrum endoscopy system, has been demonstrated to reduce the rate of missed lesions due to its wide-angle view. in the present study the authors evaluate the impact of wt on adr for high definition standard endoscopes with just a single imager to the fuse endoscope.

introduction colonoscopy outcome is strictly related to the adenoma detection rate. an endoscopy withdrawal time \>6min has been suggested to increase the adenoma detection rate since it allows for accurate evaluation of the several hidden areas of the colon. the fuse endoscope has been demonstrated also to reduce the rate of missed lesions due to its wide angle view. aim of the study to evaluate the impact on the adenoma detection rate either of the use of a fuse endoscope or of interventions directed at optimizing withdrawal time. to assess the impact of different factors in influencing the withdrawal time methods a prospective non-randomized observational single-center study involving consecutive outpatients, aged 18-85 yr, undergoing colonoscopy with different indications. previous abdominal colon resection, obstruction, inadequate preparation and incomplete examination were exclusion criteria. in a 3-month period 4 expert endoscopists will performed 500 colonoscopies either with standard endoscope or with fuse without a dedicated withdrawal time protocol. colonoscopy withdrawal times will be measured without the endoscopists' knowledge of being monitored. during a subsequent 3-month period the same endoscopists will perform further 500 colonoscopies with standard and fuse scopes using dedicated inspection techniques and a minimum 6-minute withdrawal time. in this second phase withdrawal times will be again measured, but endoscopists will be aware of being monitored. the following parameters will be recorded: * demographic and general characteristics * indications to colonoscopy * colonoscopy findings * quality of preparation: boston scale * time to reach the coecum * withdrawal time the adenoma detection rate and the mean adenomas per patients will be calculated.

Eligibility criteria:
inclusion criteria: * indication for colonoscopy, age 18-85 exclusion criteria: * previous abdominal colon resection, colon obstruction, inadequate preparation and incomplete examination

Keywords: colorectal cancer colon polyp colonoscopy adenoma detection rate
prevent pain and stress related sickleave.

Conditions: Stress, Psychological; Pain

Summary: problems with stress and pain are common reasons for long-term sick-leave, and need preventive interventions. this rct builds on a successful previous project (see reference section), where a program involving the work place, the individual and occupational health care resulted in decreased sick-leave and healthcare visits and a higher quality of life as compared to tau for individuals with musculoskeletal pain. this study will replicate and evaluate the mechanisms behind the involvement from the work place. according to the transdiagnostic model, problems with stress and pain are maintained by similar processes. consequently, the study will be extended to include both problems, and it will be explored how a refined version of the program affects sick leave and work ability in the employees.

compared to the earlier study, this rct will include: 1. a focused program targeting supervisors and employees 2. an active control group 3. an evaluation of the effects on both supervisor and employee 4. knowledge on the mechanisms involved 5. replication and extension of earlier findings the project will produce knowledge about: a procedure for identifying individuals at risk for sick-leave. the effects of a program targeting both workplace and individual to prevent problems with stress and pain. the role of the supervisor in preventing sick-leave. mechanisms linked to decreased levels of sick-leave.

Eligibility criteria:
inclusion criteria: * participating employee has self rated symptoms of stress and/or pain and supervisor also partakes in intervention * employed at a workplace within regionhälsans (occupational health care center) uptake area exclusion criteria: * pain and/or stress symptoms due to medical conditions * severe psychiatric conditions * full time sick leave
evaluating autologous stromal vascular fraction in subjects with vocal fold scar

Conditions: Vocal Fold Scars

Summary: the purpose of this research study is to assess if autologous stromal vascular fraction (svf) taken from the stomach or hips can help heal vocal fold scars.


Eligibility criteria:
inclusion criteria: * signed informed consent * subject's age between 18 and \< 80-years-old * voice handicap index greater than 10/40 * scarred vocal folds or congenital sulcus or after vocal fold surgery (scarring will be scored during examination and identification of scarred vocal folds and hoarseness. this criterion includes the lack of or decreased mucosal wave of the vocal fold during videostroboscopy exam. scoring of scar based on laryngoscopic exam: type i: atrophy of lamina propria with/without affected epithelium. type ii: the epithelium, lamina propria, and muscle are affected. type iii: scar located on the anterior commissure. type iv: this category includes extended scar formation in both anteroposterior and rostro-caudal axis, with significant loss of vocal fold mass) * unilateral or bilateral vocal fold scarring * at least 1-year delay after initial surgery * negative pregnancy test and contraception for woman of childbearing age. women of childbearing age must use contraception at least 4 months pre and post svf administration. exclusion criteria: * refusal of speech therapy * history of malignant lesion or severe dysplasia of the scarred vocal fold * contraindication to anesthesia, anticoagulant treatment, coagulation disorders, active infectious disease * refusal or inability to comply with study procedures * pregnant and lactating woman * major chronic medical condition that could affect treatment or quality of svf product. these include: * current treatment or within 6 months of last treatment for cancer. * blindness * known history of dementia, * known history of kidney disease * known history of cerebral vascular accident or stroke * known history of diabetes * abnormal screening lab. if the laboratory reports a single, non-clinically relevant, non-life-threatening result for any of these studies and is the only excluding factor it may be repeated 1 week later if the subject wishes. normalization of that laboratory study will then be considered non-exclusionary. * post-radiation scarring of vocal folds.
effect of ascorbic acid final flush on post-operative pain in mandibular molars.

Conditions: Post Operative Pain

Summary: the study is conducted to evaluate the effect of ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.


Eligibility criteria:
inclusion criteria: * patients above 18 years old and to 60. * male or female. * patients seeking root canal treatment. * mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance . * healthy patient (asa i,ii). * patient who can understand nrs and sign informed consent. exclusion criteria: * medically compromised patients having significant systemic disorders. (asa iii or iv). * history of intolerance to nsaids. * external root resorption. * internal root resorption. * vertical root fracture. * periapical lesion. * pregnancy. * use of ibuprofen in the last 12 hour. * bleeding disorder. * long term corticosteroid use. * mobility grade ii or iii. * pocket depth more than 5mm. * previous root canal therapy. * non-restorability. * tmj problems, bruxism, clenching or traumatic occlusion. * inability to perceive the given instructions.
the role of budesonide intrapolyp injection in the management of type 2 chronic rhinosinusitis

Conditions: Chronic Rhinosinusitis With Nasal Polyps

Summary: to investigate the usage of budesonide as an agent in the injection of type 2 chronic rhinosinusitis with nasal polyps

this is a randomized controlled clinical trial where 3 groups with nasal polyps will be treated medically, group a with oral corticosteroids, group b with budesonide intrapolyp injection, group c with placebo saline intrapolyp injection

Eligibility criteria:
inclusion criteria: * all patients with type 2 crswnp - * elevated serum ige \& high absolute eosinophilia * with any grade of nasal polyps * ages between 18 and 60 years old * patients who didn't have any contraindications of systemic steroids exclusion criteria: * all patients with previous nasal surgeries * all patients with cystic fibrosis, ciliary dyskinesia, antrochoanal polyp, fungal sinusitis, unilateral nasal polyps, nasal tumors, * patients who took systemic steroids in the last 6 months before our study * patients with any previous nasal surgery

Keywords: crswnp intranasal steroid injection budesonide
bioequivalence of two somatropin products (norditropin® versus genotropin®) in healthy adult volunteers

Conditions: Genetic Disorder; Prader-Willi Syndrome; Growth Disorder; Idiopathic Short Stature; Healthy

Summary: this trial is conducted in united states of america (usa). the aim of this trial is to examine the bioequivalence of norditropin® versus genotropin® in healthy adult volunteers.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) 18.0-27.0 kg/m\^2 (both inclusive) * considered generally healthy upon completion of medical history, physical examination, vital signs, screening laboratory results, and electrocardiogram (ecg), as judged by the investigator (trial physician) exclusion criteria: * the receipt of any investigational medicinal product within 1 month prior to this trial * current or previous treatment with growth hormone or igf-i (insulin-like growth factor-i) * female of childbearing potential who is pregnant, breast-feeding or intends to become pregnant or is not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) for the duration of the trial * known presence or history of malignancy * diabetes mellitus * use of pharmacologic doses of glucocorticoids * use of anabolic steroids * history of drug or alcohol abuse
the efficacy and mechanism of dbs in vic and nacc for refractory ocd

Conditions: Obsessive-Compulsive Disorder; Deep Brain Stimulation

Summary: this study will evaluate the efficacy and explore the mechanism of deep brain stimulation (dbs) in the ventral internal capsule (vic) and nucleus accumbens (nac) for refractory obsessive-compulsive disorder (ocd).


Eligibility criteria:
inclusion criteria: 1. diagnosis of ocd with duration of at least 5 years; 2. severity rated as severe to extreme illness; 3. failed adequate trial of at least three specific serotonin reuptake inhibitor (ssri) antidepressants; 4. failed augmentation with antipsychotic; 5. completed or failed to complete adequate trial of cognitive behavioural therapy for ocd; 6. stable medication regimen for one month before surgery; 7. signed informed consent; exclusion criteria: 1. hoarding as a primary symptom; 2. no other serious psychiatric disorder such as psychotic disorder; 3. drug or substance use disorder within 6 months except nicotine; 4. major neurological/medical condition; 5. high suicide risk; 6. pregnancy or lactation; 7. contraindications to stereotactic surgery; 8. contraindications to mri;
a clinical trial of cutaneous xylocaine spray to reduce intravenous cannulation pain in adults

Conditions: Pain

Summary: the enrolled subjects will get an intravenous cannulation in both elbows. the subject will get before xylocaine spray is placed, the intervention-arm, one intravenous cannulation in one of the elbows, the other intravenous cannulation is placed in the other arm before placebo spray is placed, the control arm. the pain score during insertion of the cannulation, the incidence of adverse events and the success rate and degree of difficulty to place an intravenous cannulation. the subjects and the one who place the cannulations will be blinded to the treatment.

the enrolled subjects will get an intravenous cannulation in both elbows. the influence of the left or right-handedness is reduced by randomizing the arms of the subjects in the placebo group or xylocaine group. the subject will get before xylocaine spray is placed, the intervention-arm, one intravenous cannulation in one of the elbows, the other intravenous cannulation is placed in the other arm before placebo spray is placed, the control arm. the pain score during insertion of the cannulation, the incidence of adverse events and the success rate and degree of difficulty to place an intravenous cannulation. the subjects and the one who place the cannulations will be blinded to the treatment.

Eligibility criteria:
inclusion criteria: * adults (aged 18 or older) * signing of the informed consent paper exclusion criteria: * allergy for xylocaine * pregnancy or breast-feeding * peripheral neuropathy * analgesics in the last 24 hours * skin conditions (eczema, psoriasis, infection, or abrasions) * difficulties in verbal communication * no intravenous access in both elbows possible (eg status after axillary dissection )
neuromuscular electrical stimulation in patients with interstitial lung disease

Conditions: Interstitial Lung Disease

Summary: decreased exercise capacity and quality of life, increased dyspnea and fatigue perception and hypoxemia during exercise is seen in patients with interstitial lung disease. impaired ventilatory response, increased lung compliance, ventilation-perfusion mismatching and inadequate peripheral circulation causes decreased exercise capacity. another important factor that induce decreased exercise capacity is peripheral muscle weakness. in literature, there is no study investigated effects of neuromuscular electrical stimulation on functional exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, physical activity level, dyspnea and fatigue perception in patients with interstitial lung disease.

in literature, there was increased quantity of study investigated effects of neuromuscular electrical stimulation in chronic lung disease patients. it was used as a pulmonary rehabilitation component especially in patients with decreased exercise capacity and peripheral muscle strength, intensely increased dyspnea inhibits exercise. it was demonstrated that neuromuscular electrical stimulation improved functional exercise capacity, peripheral muscle strength and quality of life.

Eligibility criteria:
inclusion criteria: * diagnosed with interstitial lung disease * clinically stable * under standard medication * having no exacerbation or infection exclusion criteria: * cognitive disorders * orthopedic and neurological problems * contraindications to apply the neuromuscular electrical stimulation (pace maker, sensory defects, etc...)

Keywords: interstitial lung disease neuromuscular electrical stimulation exercise capacity quality of life
wrist splint and occupational therapy to improve pain, mobility and functional status in patients with wrist drop

Conditions: Wrist-Drop

Summary: to determine effectiveness of wrist splint and occupational therapy to improve pain, mobility and functional status in patients with wrist drop.


Eligibility criteria:
inclusion criteria: * • people with wrist drop * people between 20 to 40 years will be included (male and female) * post-operative patients (nerve grafting and plastic surgery) * patients with findings of nerve compression will be included exclusion criteria: * • people with nerve injuries other than radial nerve such as ulnar or median nerve * people suffering with other neurological disorders. * people who are not able to follow instructions * any traumatic history * diabetic patients, thyroid issues, pregnant females
parental views related to colorado state legislation about vaccinations, schools, and child care centers

Conditions: Healthy Children

Summary: through an online survey, participants will be shown different visual presentations of vaccination data related to schools and child care centers. participants will rate how important this information is when thinking about their child's health and school choice. participants will also be asked survey questions about their knowledge of colorado state vaccination legislation, their opinions and practices related to childhood vaccinations, and their views of a zika virus vaccine.


Eligibility criteria:
inclusion criteria: * mother of a child 12 years of age or younger * english literacy to complete the survey exclusion criteria: * respondent has a child of appropriate age but that child will not attend a school or child care center outside of the home

Keywords: health communication zika virus legislation vaccination child care
intranasal dexmedetomidine versus intranasal midazolam for emergence delirium prevention

Conditions: Emergence Delirium

Summary: this study is a double-blind clinical trial, in pediatric patients aged 1-12 years with physical status asa (american society of anesthesiology) 1 and 2 who underwent eye surgery under general anesthesia using sevoflurane inhalation agents, in investigator institution during february-may 2019.. there were 64 children obtained by consecutive sampling, who underwent eye surgery in investigator institution during february-may 2019. the subjects then grouped into dexmedetomidine group and midazolam group. effectiveness was assessed from emergence delirium (ed) events, recovery time, and post-premedication desaturation events. data analysis using chi square test and mann-whitney test.

there were 64 children obtained by consecutive sampling, the subjects then grouped into dexmedetomidine group and midazolam group. effectiveness was assessed from ed events, recovery time, and post-premedication desaturation events.

Eligibility criteria:
inclusion criteria: * children undergoing ophthalmologic surgery with general anesthesia * children aged 1 - 12 years old * physical status asa 1-2 * signing informed consent exclusion criteria: * children undergoing emergency surgery * children with picu nursing after surgery * children with psychological and neurological condition * children with allergic history to dexmedetomidine and midazolam * children with history of malignant hyperthermia or family history of malignant hyperthermia * children with possibility of difficult intubation and ventilation

Keywords: emergence, delirium, dexmedetomidine, midazolam, pediatric
a study of hrs9531 versus semaglutide once weekly as add-on therapy to metformin monotherapy or in combination with sglt2 inhibitors in participants with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the study is being conducted to evaluate the efficacy and safety of hrs9531 once weekly (qw) in subjects with type 2 diabetes mellitus not adequately controlled with metformin monotherapy or in combination with sglt2 inhibitors compared to semaglutide qw for 36 weeks and 52 weeks.


Eligibility criteria:
inclusion criteria: 1. diagnosed with type 2 diabetes ≥ 90 days； 2. stable daily dose(s) for ≥3months prior to screening of : 1) any metformin formulations ≥1500 mg daily or maximum tolerated (≥1000mg daily). 2) any metformin formulations ≥1500 mg daily or maximum tolerated (≥1000mg daily) with one type of sglt-2 inhibitors; 3. glycated hemoglobin was 7.5% ≤hba1c ≤11.0%; 4. female patients of childbearing potential and male patients must agree to use highly effective contraception during the trial and for at least 2 months after the last dose of the investigational medicinal drug. female patients of childbearing potential must test negative for pregnancy at visit 1 and not be breastfeeding. exclusion criteria: 1. known or suspected allergy or intolerance to the investigational medicinal products or related products； 2. acute complications of diabetes occurred during the previous 6 months； 3. serious chronic complications of diabetes in the past； 4. use other antidiabetic drugs for ≥3months prior to screening ; 5. before screening, have disease or treatment that may affect weight; or any previous condition that may affect gastric emptying； or gastrointestinal surgery; 6. participation in any clinical trial of an approved or non-approved investigational product/treatment within the last 3 months or 5 half-lives, whichever is longer, prior to screening; 7. any conditions that the investigator judges might not be suitable to participate in the trial.
do handgrip strength and dexterity predict of respiratory function ?

Conditions: Neuromuscular Diseases

Summary: dysfunction due to weakness in respiratory muscles is one of the biggest problem that causes mortality and morbidity in neuromuscular diseases.since the nmd have a crucial life-threading natural progression, many clinicians and researchers are trying to working out to increase life span and/or quality of life with medical and rehabilitative approaches.the relationship between upper extremity functions and respiratory functions in pediatric neuromuscular patients is still not clear. the clinician working with children with neuromuscular disease should be aware of the effects of muscle weakness and cognitive dysfunction on the respiratory system. symptoms can be insidious and cause progressive loss of function, respiratory failure, and even death

background:neuromuscular diseases are acquired or hereditary diseases that affect the function of the muscles in our body caused by the nerves not sending information to your muscles and/or problems with the muscles not working properly. objective:the aim of our study is to discover more cost-effective and practical tools to predict respiratory function losses that may be a significant problem in children with neuromuscular disease. methods: hand grip strength and dexterity of children with neuromuscular disease were measured using the dynamometer and the nine-hole-peg-test respectively. the vignos and brooke upper extremity functional scales were used to evaluate functional status for patient recruitment.respiratory function parameters:forced vital capacity (fvc), forced expiratory volume in one second (fev1) and peak expiratory flow(pef) were evaluated with spirometry.

Eligibility criteria:
inclusion criteria: * to be diagnosed with nmd * to be in stage 5 or below according to the vignos scale (walking without assistance) * to be between stage 1-4 according to the brooke scale. exclusion criteria: * patients with severe systemic disease, ambulatory problem, cognitive problem, and upper extremity deformity were excluded