Kornimate/medical-research-clean huggingface dataset:
the efficacy of rad 001 as second line therapy in patients with transitional cell carcinoma tcc of the urothelium

Conditions: Urothelial Cancer

Summary: a study to determine the efficacy of everolimus(afinitor®) as third line therapy in patients with transitional cell carcinoma of the urothelium which failed or progressed after two lines of chemotherapy


Eligibility criteria:
inclusion criteria: * provision of written informed consent * male or female aged more than 18 years * histologically proven transitional cell carcinoma of the urothelium * metastatic or locally advanced disease not amenable to curative surgery and/or radiotherapy * recurrence or progression after at least one chemotherapy regimen and for unresectable/advanced disease * no more than 2 lines of previous chemotherapy.. * measurable disease (recist criteria) * previously irradiated lesions are not considered measurable- ecog performance status of 0, 1 or 2 exclusion criteria: * no prior treatment with anti cancer agents, including radiotherapy, in the last 4 weeks. * no currently active cns involvement * no pregnancy. women of child bearing potential must have a negative pregnancy test. * no uncontrolled diabetes * no symptomatic coronary artery disease, myocardial infarction within the last six months, congestive cardiac failure greater than new york heart association (nyha) class ii, uncontrolled or symptomatic cardiac arrhythmia
hypofractionated radiosurgery for localised prostate cancer (hypostat-ii)

Conditions: Prostate Cancer

Summary: hypofractionated radiosurgery has been investigated in a few trials and appears to be safe and feasible. investigators initiated this multicenter phase ii prospective trial to analyse feasibility (toxicity) of hypofractionated radiosurgery with 5 fractions in patients with localised prostate cancer under the hypothesis that the ratio of patients with late toxicity ≥ grade 2 after 3 years amounts 4.1% and is significant lower than 12.3% and 8.7% currently.

experimental radiosurgery of prostate with 5 fractions each with 7,00 gy (total application rate of 35,00 gy). planned visits are: baseline, visits at every radiation day and eight follow ups (4-6 weeks, 3 months, 6 months, 1 year and every year thereafter after last day of radiation).

Eligibility criteria:
inclusion criteria: * non-metastatic, histopathologically confirmed prostate carcinoma ct 1-3 n0 m0 * gleason-grade ≤7 * guideline-based staging * age ≥ 60 years * psa \< 15 ng / ml * volume of the prostate \< 80 cm³ * ipss-score ≤ 12 * written informed consent exclusion criteria: * age ≤ 60 years * history of prior pelvic radiotherapy * contraindication to mri or fiducial marker implantation (e.g. allergy to gold), * immunosuppressive therapy * relevant comorbidity thought to adversely affect treatment compliance, * legal incapacity or lack of informed consent

Keywords: hypofractionation prostate cancer radiotherapy long-term toxicity
analysis of internet addiction, musculoskeletal pain and body awareness in high school students

Conditions: Healthy

Summary: the study will investigate internet addiction, musculoskeletal pain and body awareness in high school students.

internet addiction is generally defined as not being able to prevent excessive use of the internet, the time spent on other occupations is not as valuable as the internet, excessive irritability and aggressive behavior when deprived.this situation brings with it musculoskeletal pain. pain in the musculoskeletal system can cause a decrease in body awareness.long periods of time spent in front of the computer, the use of non-ergonomic tables and chairs affect body awareness by causing deterioration of posture. there are several studies in literature investigating internet addiction and pain, however internet addiction, body awareness and musculoskeletal system problems of high school students have not been investigated yet. in present study, internet addiction, body awareness and musculoskeletal problems will be investigated in high school students.

Eligibility criteria:
inclusion criteria: * not having a mental disability that will prevent them from understanding and answering the questions * 15-18 years old * having internet at home * volunteering to participate in the study * having an individual device that provides internet access exclusion criteria: * no family approval * having an orthopedic, musculoskeletal or neurological disease that will affect body awareness and musculoskeletal system.

Keywords: internet addiction musculoskeletal pain body awareness high school students
vessel sealing system uvulopalatoplasty versus uvulopalatal flap

Conditions: Snoring; Obstructive Sleep Apnea

Summary: the purpose of this study is to compare vessel sealing system uvulopalatoplasty (vssu) to the traditional uvulopalatal flap (upf) in the treatment of sleep-disordered breathing with special regard to intraoperative bleeding, operative time, postoperative pain, postoperative hemorrhage and other adverse effects.

uvulopalatopharyngoplasty is one of the common procedures performed by otolaryngologists to treat sleep-disordered breathing patients who have retropalatal obstruction. intraoperative bleeding is a significant problem which requires hemostasis and causes prolonged operative time. several different techniques are used to perform this operation, including cold knife, monopolar cautery, coblation, and radiofrequency. efficacy in hemostasis and tissue trauma from different operative techniques may result in different operative time and different degrees of morbidity including intraoperative blood loss, postoperative pain, postoperative hemorrhage, and velopharyngeal insufficiency (vpi). the vessel sealing system has been widely used in head and neck surgery because of its effectiveness and safety. it was also found quite effective and safe in tonsillectomy procedures, providing excellent hemostasis and minimal tissue trauma.

Eligibility criteria:
inclusion criteria: * patient planned for uvulopalatoplasty for indications of snoring or obstructive sleep apnea * written informed consent form is given from patient exclusion criteria: * pregnancy * history of bleeding disorders * patient unable to understand evaluation method * patient unable to be contacted via telephone

Keywords: vessel sealing system uvulopalatoplasty uppp uvulopalatal flap bleeding operative time adverse effects
feasibility randomised-controlled trial of online stroke interventions

Conditions: Stroke

Summary: many people have difficulties organising their behaviour and problem-solving (also known as executive function difficulties) after stroke. this can have serious, wide-ranging consequences for wellbeing and ability to regain independence. currently, access to psychological interventions after stroke varies and there is not enough evidence to recommend a specific intervention for executive function difficulties after stroke. a short intervention was designed to help with executive function difficulties by making it easier to set goals and achieve them after stroke. the intervention is designed for online delivery to make it accessible to as many stroke survivors as possible. the present trial aims to investigate the acceptability and feasibility of a single blinded randomized controlled trial of this online executive function intervention (active intervention) compared to an online stroke psychoeducation intervention (control intervention).


Eligibility criteria:
inclusion criteria: * diagnosis of stroke * ≥ 18 years of age * capacitous consent to participate * access to a computer / tablet, the internet, and an email address exclusion criteria: * another significant mental or physical health condition * current involvement in another research trial * severe depression (over 20 on phq-9) * not able to read or understand english * visual, auditory or motor difficulties of a severity that limit the ability to attend to the content of the interventions, read the participant information sheet or complete the consent form and outcome measures * not registered with a gp or unwilling to provide gp information (for reporting suicidal ideation concerns

Keywords: stroke executive functions goal management problem-solving psychoeducation telerehabilitation
pharmacokinetics of ssri/snri after bariatric surgery

Conditions: Obesity; Depression

Summary: psychiatric disorders and treatment with antidepressants ssri/snri (selective serotonin reuptake inhibitors/ serotonin-norepinephrine reuptake inhibitors) are common in people with morbid obesity who are candidates for bariatric surgery. although longitudinal assessments reveal positive effects of bariatric surgery on quality of life and mood, depressive disorders may also deteriorate after bariatric surgery. there is few and inconsistent data about the postoperative pharmacokinetics of ssri/snri. the aims of our study were to provide comprehensive data about the postoperative bioavailability of ssri/snri, and the clinical effects on the course of depression.

prospective multicenter study including 63 patients (i.e. 46 participants in the bariatric surgery group, and 17 participants in the conservative group as controls) with morbid obesity and therapy with ssri/snri: participants filled the beck depression inventory ii (bdi) questionnaire, and plasma levels of ssri/snri were measured by hplc (high performance liquid chromatography), preoperatively (t0), 4 weeks (t1) and 6 months (t2) postoperatively.

Eligibility criteria:
inclusion criteria: * age \>18 years * bmi \>35 * existing antidepressant drug therapy with ssri or snri * written informed consent exclusion criteria: * taking other psychotropic drugs than ssri/snri * active drug addiction or psychosis * severe depression (bdi score \>30) * suicidality at the beginning of the study * gastrointestinal malabsorption * pregnancy

Keywords: ssri/snri bariatric surgery
ventricular and pulmonary vascular reserve after the fontan operation

Conditions: Heart Failure; Congenital Heart Disease

Summary: aim #1: define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing. aim #2: determine the role of rest-exercise echocardiography for the assessment hemodynamics in fontan physiology. aim #3: evaluate the clinical impact of pulmonary vascular disease and ventricular diastolic dysfunction.

define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing. subjects with fontan palliation will undergo cardiac catheterization during exercise. the investigators hypothesize that invasive hemodynamic assessment during supine exercise will enable identification of early stage pulmonary vascular disease and diastolic dysfunction that is not apparent from invasive studies performed at rest. determine the role of rest-exercise echocardiography for the assessment hemodynamics in fontan physiology. transthoracic echocardiography will be performed at rest and during exercise simultaneously with catheterization in the subjects participating in aim #1 to determine correlations between invasive and noninvasive hemodynamics and identify noninvasive alternatives to assess functional reserve. evaluate the clinical impact of pulmonary vascular disease and ventricular diastolic dysfunction. multi-organ function and patient reported outcomes will be evaluated at baseline, 12 months (optional), and 24 months (optional) in subjects participating in aims #1 and #2. the investigators hypothesize that subjects with poorer ventricular-vascular reserve will display more clinical and end-organ deterioration in longitudinal follow up.

Eligibility criteria:
inclusion criteria: * fontan palliation * age ≥18 years exclusion criteria: -no clinical indication for cardiac catheterization
acceptance and commitment therapy for neuro-oncology wellbeing

Conditions: Brain Tumors; Quality of Life; Brain Tumor, Pediatric

Summary: background. survivors of childhood brain tumours have the poorest health-related quality of life of all cancer survivors due to the multiple physical and psychological sequelae of brain tumours and their treatment. remotely delivered acceptance and commitment therapy (act) may be a suitable and accessible psychological intervention to support young people who have survived brain tumours. aims. this study aims to assess the feasibility and acceptability of remotely delivered act to improve quality of life among young brain tumour survivors. method. this study is a two-arm, parallel group, randomised controlled trial comparing act with waitlist control. participants will be aged 11-24 years and survivors of brain tumours who have completed cancer treatment. participants will be randomised to receive 12 weeks of act either immediately or after a 12-week wait. the durability of treatment effects will be assessed by further follow-up assessments at 24-, 36- and 48- weeks. the dna-v model of act will be employed, which is a developmentally appropriate model for young people. feasibility will be assessed using the proportion of those showing interest who consent to the trial and complete the intervention. a range of clinical outcome measures will also assess physical and mental health, everyday functioning, quality of life and service usage. acceptability will be assessed using participant evaluations of the intervention, alongside qualitative interviews and treatment diaries analysed thematically. discussion. this study will provide an initial assessment of the value of remotely delivered act in supporting recovery and coping for young people after brain tumour treatment.


Eligibility criteria:
inclusion criteria: * aged 11-to-24 years at the time of randomisation * received treatment for a brain tumour at a participating principle treatment centre * active brain tumour treatment is complete and their condition stable for at least six-months * have sufficient cognitive ability to engage with act sessions as judged by the clinician at baseline assessment * competent to provide informed consent (participants aged 16 or over) or assent (participants aged 11-15) * parent/carer competent to provide informed consent (for participants aged 11-15) exclusion criteria: * received a structured behavioural intervention within six-months prior to study recruitment * previous or current alcohol/substance dependence, psychosis, suicidality, or eating disorder * moderate or severe intellectual disability, confirmed through researcher judgement at screening through questions relating to school type and previous diagnoses * immediate risk to self or others * the patient or their parent/carer is not able to speak, read or write english

Keywords: acceptance and commitment therapy cancer oncology quality of survival children and adolescents
assessment of severity and prognosis for patients with status epileptics(se)

Conditions: Status Epileptics

Summary: to characterize the functional outcomes and prognostic factors for convulsive status epilepticus (se) and to further develop and validate a simple and practicable scoring system for outcome prediction.

1. retrospectively study all patients with convulsive se treated between march, 2008, and november, 2014. 2. develop a scoring system for outcome prediction. 3. prospectively validate the predictive accuracy of the scoring system

Eligibility criteria:
inclusion criteria: * 30 min or more of (1) continuous clinical seizure activities or (2) recurrent seizure activities without recovery(returning to baseline)between seizures; * clinical data is complete. exclusion criteria: * hypoglycemia se;psychogenic se;any other pseudo-se

Keywords: status epileptics prognosis risk factor outcome
serum endostatin type 2 diabetic patients

Conditions: Diabetes Mellitus, Type 2; Coronary Artery Disease; Coronary Arteriosclerosis

Summary: to assess the relationship between serum endostatin (es) and coronary artery calcification (cac) in type 2 diabetic (t2dm) patients.

elevated serum endostatin levels were independently associated with increased risk, severity and progression of coronary artery calcification independent of traditional cardiovascular disease risk factors in t2dm subjects with known coronary artery disease. so, measurement of serum es levels can improve the diagnosis of coronary artery calcification and could be useful as a high sensitive marker for the presence and progression of atherosclerosis in t2dm patients.

Eligibility criteria:
inclusion criteria: - patients were between the ages of 50 and 70 years at enrollment. * symptomatic or previously recognized coronary artery disease for all the study population. * type 2 diabetic patients with the onset of type 2 diabetes occurred at age 30 years or older with no history of ketoacidosis for group ii subjects. exclusion criteria: * left ventricular ejection fraction (lvef) ≤40%, chronic heart failure, unstable angina, myocardial infarction, arrhythmia, valvular heart disease, coronary artery bypass surgery, and history of stent placement, liver diseases, malignancy, glomerular filtration rate index \ 30 kg/m2 or \< 15 kg/m2, pulmonary edema, stroke, acute infections, severe trauma, recent surgery, inflammatory conditions, thyrotoxicosis, pregnancy and known allergic reactions.
morphea in adults and children (mac) cohort study: a morphea registry and dna repository

Conditions: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

Summary: the morphea in adults and children (mac) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. the purpose of the registry is to learn more about morphea, specifically: * how morphea behaves over time * how frequently specific problems occur along with morphea (for example, arthritis) * whether morphea has an autoimmune background


Eligibility criteria:
inclusion criteria: 1. patient must have a clinical diagnosis of morphea confirmed by the primary investigator and by histopathological examination. 2. ages 0-90 years old 3. children must weigh more than 20 lbs. in order to satisfy children's medical center policy for the maximum amount of blood drawn in a 24 hour period. 4. patient or legal guardian must be able to speak and read at a 6th grade reading level. 5. both male and female patients will be eligible 6. all races and ethnic backgrounds will be included 7. relationships to proband: all patients with morphea will be included. a patient's family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigator's contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so. 8. ability to give informed consent: patients must be able to give informed consent or they will give assent with parent or guardian consent as a minor to be a part of the morphea registry. exclusion criteria: - patients who have been coded as morphea (701.0), but do not have morphea/localized scleroderma (examples: steroid atrophy, acquired keratoderma, keloids, nephrogenic fibrosing dermopathy, systemic sclerosis, lichen sclerosis)
correlation between visual field defects on foresee home and on optical coherence tomography in choroidal neovascularization subjects

Conditions: Age Related Macular Degeneration

Summary: the foresee home is used in the recent years to detect age-related macular degeneration (amd) lesions. the device is capable of differentiation as to stages of amd and early detection of changes including choroidal neovascularization (cnv) the foresee home demonstrates a high level of sensitivity and specificity as to the different stages of amd including newly diagnosed or early detection of cnv. the oct may be use as well to identify choroidal neovascularization (cnv). comparison between the two methods will allow better understanding of both devices. the foresee home can use as an assessment tool for the progression and success of the treatment given to amd lesions. therefore, evaluation the size and the location of the treated lesions may serve as an additional tool.


Eligibility criteria:
inclusion criteria: * capable and willing to sign a consent form and participate in the study * subjects diagnosed with cnv * did not perform more then 4 anti- vgef injections * va with habitual correction better then 6/45 in the study eye * ability to understand instructions * familiar with computer usage exclusion criteria: * evidence of macular disease other than amd or glaucoma in the study eye * presence of any significant media opacity that precludes a clear view of the macular area as identified in the study eye by biomicroscopy, * any non-macular related ocular surgery performed within 3 months prior to study entry in the target eye * participation in another study with the exclusion of areds study

Keywords: hmp cnv amd php hphp foresee home
the genetic basis of inherited neurologic deficits in people with schizophrenia

Conditions: Schizophrenia

Summary: this is a study of the genetic basis of brain dysfunction in people with schizophrenia.

schizophrenia is a disabling disorder that is associated with specific inheritable neurobiologic deficits. these deficits can cause problems with memory, visual attention, information processing, and other aspects of daily living. understanding the genetic components of these deficits in people with schizophrenia and their unaffected family members may help uncover the neurobiological basis, risk factors, and heritability of the disease. in addition, the information may serve to create more effective treatments and possibly a cure for the disease. this study will serve to provide information about the genetic basis of known inherited neurobiological deficits in people with schizophrenia. in turn, this may guide further studies on the genetics of schizophrenia. participants will attend 2 study visits, each of which will last approximately 4 hours. the first will include blood tests and diagnostic interviews of participating families to evaluate the presence of schizophrenic symptoms. the second study visit will entail four neurocognitive and neurophysiological tests. participants will first have a pre-pulse inhibition test, which uses electrodes to measure eye blinking. electrodes will also be placed on participants' head, ears, and around their eyes to measure brain waves. next, participants will undergo an oculomotor test, during which they will wear glasses fitted with sensors that record eye movement. participants will then be asked to repeat a list of words, letters, and numbers read by a researcher. last, participants will undergo a computerized performance test requiring them to watch the computer screen and click a mouse whenever they see a number between 0 and 9. each study visit will take approximately 4 hours.

Eligibility criteria:
inclusion criteria for participating families: * families with at least one member who has schizophrenia exclusion criteria: * n/a

Keywords: mental health psychosis genetics heredity