Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of cannabidiol for gastroparesis and functional dyspepsia

Conditions: Gastroparesis; Dyspepsia

Summary: researchers are looking at the effects of a cannabidiol medication on stomach function in people with gastroparesis (a paralyzed stomach) and people with dyspepsia (an upset stomach caused by improper functioning of the stomach's muscles or nerves).


Eligibility criteria:
inclusion criteria: * patients with gastroparesis or functional dyspepsia (fd) * age 18-70 years * patients will be identified from among mayo clinic patients. * patients will have symptoms consistent with gastroparesis based on a national guideline for gastroparesis (symptoms plus delayed gastric emptying of solids). patients with rome iv criteria for postprandial distress syndrome (a subset of functional dyspepsia) will be selected based on gastric emptying of solids which is not delayed, in addition to standard fd criteria: * symptoms fulfilled for the last 3 months with onset greater than 6 months before diagnosis: * one or more symptoms being bothersome: postprandial fullness, early satiation, epigastric pain or burning * must include one or both of the following at least 3 days per week: bothersome postprandial fullness (i.e., severe enough to impact on usual activities) or bothersome early satiation (i.e., severe enough to prevent finishing a regular-size meal) * no evidence of organic, systemic, or metabolic disease to explain the symptoms on routine investigations. * participants will have previously undergone test of gastric emptying of solids using the standardized mayo clinic scintigraphic method * ability to provide informed consent * absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results * body mass index of 18-35 kg/m2 * several medication classes, particularly those affecting gastrointestinal transit or motor functions, will be excluded, including glp-1 receptor or amylin agonists in patients with diabetes mellitus. stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control (but with adequate backup contraception, as drug interactions with birth control have not been conducted for secretin pam) are exclusion criteria: * patients with current h. pylori infection will be excluded. * pregnancy or lactation * rapid metabolizers for cyp3a4 or cyp2c19 \[estimated prevalence of 17% and 18% respectively * based on literature review will be excluded since this could impact assessment of effects of cannabidiol * patients with abnormal baseline liver transaminases (any value above unl), since up to 3-fold, dose-related elevations of liver transaminases (alt and/or ast) occur in 13% of treated patients (vs. 1% placebo); * hypersensitivity to cannabidiol or any of the ingredients in epidiolex * concomitant use of valproate, central nervous system (cns) depressants and alcohol, other hepatotoxic drugs
low back pain and osteopathy in italian young people

Conditions: Low Back Pain

Summary: this is a behavioral observational study aimed at evaluating the presence of low back pain in young people and the intention to undertake osteopathic treatments. it consists of a short self-administered questionnaire which will be given to adolescents with gnathological/orthodontics disorders to complete. relationships between low back pain of young individuals' answers with the intention to undertake osteopathic treatments will be evaluated.

this is a behavioral observational study aimed at evaluating the presence of low back pain in young people and the intention to undertake osteopathic treatments. literature found out that low back pain is a common occurrence in young people. adolescents develop frequently gnathological/orthodontics disorders. in italy, young individuals with low back pain and gnathological/orthodontics disorders are frequently referred to osteopaths. in literature there are not studies which correlate low back pain, osteopathic cures and gnathological/orthodontics disorders as for young persons. the study consists of a short self-administered questionnaire which will be given to young people to complete. in more details, the survey is made of 8 questions collecting information on presence/intensity of low back pain, intention to have osteopathic treatments, and (in that case) the satisfaction after the cures. further, participants will have to complete a self-administered pain intensity numerical rating scale. descriptive statistics will be presented by taking into account the socio-demographic characteristics of the sample being investigated. statistical correlations between adolescents' answers and the pain intensity numerical rating scale will be also evaluated. this study investigates the relationships among low back pain, gnathological/orthodontics disorders, and osteopathic cures.

Eligibility criteria:
inclusion criteria: * common low back pain * ability to read and understand the italian language exclusion criteria: * any diagnosable cause of low back pain * previous spinal surgery * cognitive impairment * refusal to adhere

Keywords: low back pain gnathology orthodontics osteopathy young people behavioral medicine
preventing weight gain and unhealthy behaviors in children

Conditions: Obesity

Summary: this study will address engagement in unhealthy behaviors, low levels of self-regulation, and unhealthy weight gain for children from low-income households.

evidence suggests that components within structured days (e.g., school days) have a positive influence on children's obesogenic behaviors (i.e., diet, sleep, physical activity, sedentary behaviors) and self-regulation. in this pilot study children will be randomized to two arms: attend a structured summer camp, not attend a camp. the investigators hypothesize that children attending the summer camp will engage in more healthy obesogenic behaviors, display higher levels of self-regulation, and subsequently will experience less weight gain than children not attending the summer camp. to test this hypothesis the following specific aims will be accomplished: aim 1 (primary): compare changes in bmi z-scores and fitness among children from low-income households attending a structured summer day camp and those not attending a structured summer day camp. aim 2 (secondary): compare changes in obesogenic behaviors among children attending a structured summer day camp and those not attending a structured summer day camp. aim 3 (exploratory): explore changes in self-regulation and the moderating effect of these changes on primary and secondary outcomes among children attending and not attending a structured summer day camp.

Eligibility criteria:
inclusion criteria: * participants will be boys and girls that attend one of the participating schools * indicates "yes' on an informed consent document for participation in the study exclusion criteria: * diagnosis of an intellectual disability, such as down syndrome, fragile x, fetal alcohol and/or a physical disability, such as wheelchair use, that prevents the ability to ambulate without assistance. * children who plan to enroll in a summer camp during the year that they participate in the study will also be excluded from the study. * no other exclusion criteria will be used.
arsenic trioxide in treating patients with relapsed or refractory acute myeloid leukemia

Conditions: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia

Summary: this phase ii trial studies how well arsenic trioxide works in treating patients with relapsed or refractory acute myeloid leukemia. drugs used in chemotherapy, such as arsenic trioxide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

primary objectives: i. determine the complete remission rate of relapsed and refractory acute myeloid leukemia (aml) patients with mutated nucleophosmin 1 (npm1) gene. secondary objectives: i. determine the duration of remission in these patients. ii. determine the in vivo biological effect of arsenic trioxide in aml with mutated npm1. outline: patients receive arsenic trioxide intravenously (iv) over 1-2 hours daily for up to 45 days. patients achieving complete remission, receive arsenic trioxide iv over 1-2 hours daily 5 days a week for 4 weeks. treatment repeats every 8 weeks for up to 4 courses in the absence of disease progression or unacceptable toxicity.

Eligibility criteria:
inclusion criteria: * aml, any french- american- british (fab) subtype except m3, with confirmed mutation in the npm1 gene * relapsed and/or refractory aml from any duration of complete remission (cr); any number of prior therapies allowed * eastern cooperative oncology group (ecog) performance status 0-2, life expectancy \> 3 months * serum creatinine =\< 2.0 mg/dl * bilirubin =\< 2.0 mg/dl * alanine aminotransferase (alt)/aspartate aminotransferase (ast) =\< 3 x upper limit of normal (uln) * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * pregnant or breast-feeding women will not be entered on this study due to risks of fetal and teratogenic adverse events as seen in animal/human studies; pregnancy tests must be obtained in women; sexually active males or females may not participate unless they have agreed to use an effective contraceptive method * patients who are currently receiving another investigational drug * patients who are currently receiving other anti-cancer agents * uncontrolled systemic fungal, bacterial, viral, or other infection (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite appropriate antibiotics or other treatment) * known hypersensitivity to arsenic trioxide
the effects of therapeutic exercises on kinesiophobia in haemophilic patients.

Conditions: Haemophilia

Summary: this study evaluates the effects of therapeutic exercises on kinesiophobia and health-related quality of life in adult haemophilia patients. half of participants will receive therapeutic exercises and verbal information about the positive effects of therapeutic exercises on physical pathologies due to hemophilic arthropathy while the other half will receive only verbal information.

in haemophilia patients recurrent musculoskeletal hemorrhage cause to arthropathy characterized by severe degeneration of joint cartilage and bones. arthropathy leads to decrease in the patient's health related quality of life. furthermore pain, risk of injury and lack of motivation lead to decreased physical activity and development of kinesiophobia.

Eligibility criteria:
inclusion criteria: * individuals older than 18 years * diagnosed with hemophilia a or b * having at least one joint with hemophilic arthropathy * without cognitive problems * speaking turkish exclusion criteria: * individuals with another congenital coagulopathy such as von willebrand syndrome, * unable to walk due to hemophilic arthropathy * developing inhibition against factor viii-ix
nonverbal communication in aged people

Conditions: Alzheimer Disease

Summary: musical interventions improve the emotional state of patients with alzheimer's disease (ad) while having a positive impact on the caregiver's well-being. however, the factors that could be responsible for this positive effect remain unknown. among these, the sensory-motor synchronization (sms) of movements to the musical rhythm, frequently observed during musical activities and possible up to the advanced stages of ad, could modulate the emotional state. several recent studies have shown that rhythmic training (or sms) influences the organism at the motor, cognitive and social levels while activating the cerebral reward circuit. this action that generates pleasure also facilitates non-verbal emotional expression. however, the conditions that modulate sms and their relationship to nonverbal communication, emotional, behavioral and cognitive state have not yet been studied in healthy or pathological elderly.


Eligibility criteria:
inclusion criteria: cases : patients with neurodegenerative disease (ad or related disease) * native french language * corrected auditory and/or visual deficiency * right-handed * image rights consent signed by the patient controls: people with no neuropathological disease * native french language * corrected auditory and/or visual deficiency * right-handed * image rights consent signed by the control exclusion criteria: -

Keywords: music communication emotion behavior neurodegeneration disease
t3 certain tapered with dcd vs t3 certain tapered non-dcd

Conditions: Edentulous Jaw

Summary: this will be a prospective, randomized multicenter study to determine the safety and efficacy of the t3 certain tapered with dcd as compared to t3 certain tapered without dcd. all implants will be placed in the maxilla or mandible in a single stage manner and loaded with prosthesis after 6 weeks of healing. final restorations will take place no later than 4 months following implant placement surgery. the implants will be evaluated yearly for 2 years.

this is a multicenter, prospective, randomized study that will assess the the safety and efficacy of the implant systems with: * resistance to countertorque testing (mobility) * implant stability quotient (isq) * changes in peri-implant crestal bone levels * confirmation of clinical benefits a total of 60 implants, 30 per treatment group will be placed across all participating sites. one patient may contribute more than 1 implant. all implants/ patients will be followed for up to 2 years.

Eligibility criteria:
inclusion criteria: 1. patients of either sex and greater than 18 years of age 2. patients for whom a decision has already been made to use a dental implant in the mandible or maxilla. 3. immediate extraction or a prior extracted site 4. patients must be physically able to tolerate conventional surgical and restorative procedures. 5. presence of opposing dentition 6. patients who provide a signed informed consent. 7. patients who agree to be evaluated for each study visit. 8. minimum primary stability, insertion torque \> 35ncm exclusion criteria: 1. patients with known systemic diseases such as uncontrolled diabetes, endocrine disease, heart disease, immuno-compromised, or mental disorders. 2. patients with current use of non-steroidal anti-inflammatory drugs, bisphosphonates or corticosteroid treatments. 3. patients with active infection or severe inflammation in the areas intended for implant placement. 4. patients with a \> 10 cigarette per day smoking habit. 5. patients with a history of therapeutic radiation to the head or jaw. 6. patients who are known to be pregnant at the screening visit or planning to become pregnant within 6 months of study enrollment. 7. patients with evidence of severe parafunctional habits such as bruxing or clenching. 8. patients with hiv or hepatitis infection
safety and efficacy evaluation of two different brilliant blue g dyes as staining agent in vitreo retinal surgery.

Conditions: Macular Holes; Epiretinal Membrane

Summary: this is a prospective, open-label, comparative clinical study to asses two brilliant blue g dyes as staining agent in vitro retinal surgery.

the study was designed as prospective, open label, comparative observational study. the patients over 18 years old and undergone macular surgery, internal limiting membrane removal surgery or vitreomacular traction using the two brilliant blue g dyes as staining agent in vitro retinal surgery were planned to enroll the study. two blue g dyes (bio blue 90 plus and ilm blue) was randomly assigned at the subject's initial intraoperative visit, according to a computer-generated randomization schedule. during the pars plana vitrectomy, bio blue 90 plus or ilm blue dyes were injected into eye to stain ilm. injected dye was removed from the eye at the end of study before injecting long term tamponade. a total of 5 visits were conducted during the study. out of them pre-operative visit was done on 1 visit, surgery/intraoperative visit and thereafter there were three follow-up visits. the follow- up visits were performed at 1 month, 3 months and 6 months after the completion of surgery. clinical evaluation will be done recording and using staining ability of ilm (intra-operatively), visualization of stained membrane (intra-operatively),oct parameters: (pre-op \& post-op follow-up), ffa parameters: (pre-op \& post-op follow-up),fundus auto fluorescence (faf), multifocal erg (pre-op \& post-op follow-up) and visual field analyses (pre-op \& post-op follow-up).

Eligibility criteria:
inclusion criteria: * over 18 years of age * patient undergone macular surgery, epiretinal membrane removal surgery or vitreomacular traction using the study device * patient who can attend all the regular follow-up examinations as per the routine schedule. * willingness to adhere to the protocol requirements as evidenced by the informed consent form (icf) duly read signed and dated by the patient. exclusion criteria: * standard exclusion criteria for macular surgery like trauma history, previous macular surgery, rhegmatogenous retinal detachment together with macular hole, myopia higher than 10 diopter (d), macular hole for more than 2 years and previous retinal vessel disease. * participated in any study during the use of the study device.

Keywords: brilliant blue g dye ilm pealing macular hole
measure the serum level of homocysteine in acne patients before and after oral isotretinoin.

Conditions: Acne Vulgaris

Summary: serum homocysteine level in acne patients before and after oral isotretinoin and correlation between serum level of homocysteine in acne patients before and after oral isotretinoin treatment

acne vulgaris is a common chronic inflammatory disease of the skin. it is found in about 80% of young adults and adolescents. it is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne the standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris the scope of our study is to detect serum homocysteine level in acne patient befor and after oral isotrtinoin treatment

Eligibility criteria:
inclusion criteria: * patients of both sexes with acne vulgaris exclusion criteria: * patients with history of malignancies. * patients with renal and hepatic dysfunction. * cardiac patient. * pregnant, lactating and female welling to have pregnancy in the period of study. * patient with absorption disorder. * patient with history of favism. * patient has already been treated with isotretinoin.
breathibg exercises and inhaler trainingfor chronic obstructive pulmonary disease (copd) patients

Conditions: COPD; Breathlessness; Aerocele

Summary: the most common symptom of chronic obstructive pulmonary disease (copd) is shortness of breath and causes a decrease in the patient's quality of life. the best way to relieve shortness of breath is inhaler therapy. however, it is known that patients frequently apply this treatment incorrectly. the aim of this study is to determine the effects of breathing exercises and inhaler training for copd patients on the severity of dyspnea and life quality. for this, two patient groups with a total of 67 people were included in the study. while one group was trained on inhaler drug use, the other group was taught breathing exercises in addition to the inhaler drug use training. patients were asked to continue the practices they learned regularly for 4 weeks. at the end of the study, it was observed that shortness of breath decreased and the quality of life increased in both patient groups.


Eligibility criteria:
inclusion criteria: * the individuals over the age of 18, * who had been diagnosed with copd for at least three months, * using inhalers at least twice a day, * misusing their drug, * had not previously taken breathing exercise training * had not participated in a rehabilitation program exclusion criteria: * mental disorders, * communication disabilities, * heart disease that could lead to dyspnea, * unstable angina

Keywords: copd inhaler training breathing exercises dyspnea quality of life
ending the epidemic interventions in the dental setting - uh3

Conditions: HIV-1-infection

Summary: the purpose of this study is to use information technology (it) to support the efficient delivery of hiv prevention and care best practices in the dental care setting.

routine preventative hiv screening in all health care settings is considered a best practice by the centers for disease control and prevention (cdc), department of health and human services (dhhs) ending the epidemic (ete) initiative, the new york state blueprint to end the aids epidemic. despite this, many patients are not screened for hiv during routine care, including in dental care settings, resulting in missed opportunities for identifying undiagnosed hiv infections and providing education for pre-exposure prophylaxis (prep). this study will use information technology to support the delivery of hiv prevention and care best practices in the dental care setting. dental residents will receive a best practice (bpa) alert whenever they have a patient who should be offered hiv screening. this bpa is linked to an order set to simplify ordering hiv tests and reporting results. a critical knowledge gap for implementing these ete activities in the dental setting is whether comprehensive ete efforts could be integrated into existing dental teams consisting of practitioners, dental assistants and hygienists or require augmentation by a dedicated care navigator. to evaluate these two models, the investigators will conduct a crossover clinical trial in 3 urban general dentistry programs (nyp-columbia, nyp-cornell, nyp-queens) randomized to one of 2 arms: (ab) standard dental care team model followed by crossover to an enhanced dental care team model with a care navigator, or (ba) enhanced dental care team model with a care navigator followed by crossover to a standard dental care team model.

Eligibility criteria:
inclusion criteria: * member of the dental team (provider, hygienist, dental assistant, care navigator) at one of the randomized sites with direct patient contact * able to provide written informed consent. exclusion criteria: - inability to provide written informed consent.

Keywords: clinical decision support acceptability feasibility implementation science hiv testing