Kornimate/medical-research-clean huggingface dataset:
swog-8947 collecting and storing blood samples from patients with previously untreated non-hodgkin lymphoma

Conditions: Lymphoma

Summary: rationale: collecting and storing samples of blood from patients with cancer to test in the laboratory may help the study of cancer in the future. purpose: this research study is collecting and storing blood samples from patients with previously untreated non-hodgkin lymphoma.

objectives: * to establish a central lymphoma serum repository that will serve as a resource to provide specimens for current and future scientific studies. * to utilize the southwest oncology group clinical database to perform clinicopathologic correlations with the results of those studies. outline: serum is collected and stored for future correlative studies.

Eligibility criteria:
disease characteristics: * diagnosis of non-hodgkin lymphoma * previously untreated disease * patients must meet the eligibility criteria and be registered to a currently active southwest oncology group-coordinated treatment protocol for previously untreated non-hodgkin lymphoma patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: non-hodgkin lymphoma
oocyte vitrification aided with cytochalasin b

Conditions: Infertility

Summary: using the cytoskeleton stabilizer the cytochalasin b would improve the outcome of oocyte vitrification.


Eligibility criteria:
inclusion criteria: * indication for oocyte vitrification exclusion criteria: -
effects of pesticide exposure on neurodevelopment/growth/respiratory health

Conditions: Environmental Exposure

Summary: exposure and health study of pesticide and allergen exposures to pregnant women and children. intervention study is planned after assessment is completed.

exposure assessment and pathway analysis of organophosphate pesticides to low income pregnant women and children living in the salinas valley of california. health study investigating neurodevelopment, growth, and asthma in children.

Eligibility criteria:
* female, at least 18 years of age. * live in salinas valley in california. * pregnant. * medical eligible.

Keywords: epidemiology pesticide asthma children exposure
the effect of telerehabilitation in patients with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: telerehabilitation enables patients to easily adapt to home exercise programs and to be monitored remotely by their clinicians. the aim of this study is to investigate the effectiveness of the home exercise program, which is integrated into 8-week remote asynchronous video telerehabilitation sessions, on clinical status in terms of pain, functionality, quality of life parameters, as well as patient expectation, motivation, and satisfaction levels.

low back pain is symptomatic pathology in the region between the twelve ribs and lower gluteal line defined as the lumbar region and sometimes accompanied by radicular symptoms spreading to the lower extremity, but it is not considered as a pathology alone. they are evaluated and treated on the basis of symptom duration, potential cause, the presence or absence of radicular symptoms, and the corresponding anatomical or radiographic abnormalities. exercise is considered an essential element in the management of physical therapy and rehabilitation in patients with chronic low back pain. however, it has been found in the studies that improvements after physical therapy and rehabilitation applications are not preserved in the long term, and recurrence of chronic low back pain is common. in order to prevent this, physiotherapists need to follow their patients for a long time and to participate in the rehabilitation process. with a more cost-effective treatment model such as telerehabilitation, patients can be followed up more efficiently during home exercise. the aim of this study is to investigate the effectiveness of the home exercise program, which is integrated into 8-week remote asynchronous video telerehabilitation sessions, on clinical status in terms of pain, functionality, quality of life parameters, as well as patient expectation, motivation, and satisfaction levels.

Eligibility criteria:
inclusion criteria: * male and female patients aged 18-65 * patients who have complained of low back pain for at least 3 months * pain and numbness that does not spread to the legs exclusion criteria: * patients with cognitive disorders or communications problems to complete assessments or treatment interventions. * individuals who have undergone surgical operations on the spine and/or extremities * specific pathological conditions (e.g. malignancy, fracture, systemic rheumatoid disease) * orthopedic and neurological problems that prevent evaluation and/or treatment * complaints of pain and numbness spreading to the lower extremities * individuals with a diagnosed psychiatric illness * individuals who have received physiotherapy in the last 6 months * individuals who use another treatment method during the study * individuals with musculoskeletal pain in any other part of the body during work * pregnancy

Keywords: chronic low-back pain telerehabilitation pain quality of life motivation expectation patient satisfaction
decision aid for patients with generalized anxiety disorder: protocol for a randomized controlled trial

Conditions: Generalized Anxiety Disorder; GAD

Summary: the main goal of this study is assess the effectiveness of a ptda for patients with gad.

background: patients with generalized anxiety disorder (gad) have concerns and needs about their health and the health care they receive. patient decision aids (ptdas) are tools that assist patients in making health decisions, when there is uncertainty about treatment choice, incorporating their personal preferences and values about the available treatment options. ptdas can improve shared decision-making (sdm) and lead to better treatment outcomes. the aim of this study is to evaluate the effectiveness of a web-based ptda for patients with gad in primary care. methods and analysis: the general study design comprises two stages: i) development of a web-based ptda for patients with gad, derived from an evidence-based clinical practice guideline and, ii) assessment of the effectiveness of the ptda employing in a randomised controlled trial (rct) design, in primary care centres of tenerife (spain). this rct will be carried out with 156 patients with gad with a score ≥8 in the gad-7 questionnaire, comparing the ptda to usual care (fact sheet with general information on mental health). patients will review the ptda accompanied by a researcher. post-intervention survey will be administered immediately after the intervention. the primary outcome will be decisional conflict (immediately after intervention and 3 months after intervention). secondary outcomes will include knowledge about gad and its treatment (immediately after intervention and 3 months after intervention), treatment preference (immediately after intervention), actual treatment choice (3 months after intervention), concordance between preferred and chosen (3 months after intervention) decision quality with the decision-making process (3 months after intervention), and gad symptoms (3 months after intervention).

Eligibility criteria:
inclusion criteria: * adult (≥ 18 years) with a diagnosis of gad (icd-10 or dsm-v codes: 300.02; f41.1), with a score ≥8 in the gad-7 questionnaire, with ability to speak and read spanish, and who accept to participate and sign the informed consent exclusion criteria: * patients with a primary diagnosis other than gad, a score \<8 in the gad-7, those with significant physical or mental disability that prevents from completion of study activities or those participating in other trials related with gad treatment or education, will be excluded

Keywords: generalized anxiety disorder patient decision aids patient-centred care randomized controlled trial shared decision making web-based intervention primary care
evaluation of oral condition and the effect of dental treatment on physical parameters of athletes

Conditions: Periodontal Diseases; Inflammation Gum; Caries,Dental

Summary: it is essential that athletes have perfect general health. oral health plays an important role in this healthy framework necessary so that the results that must be achieved by athletes are not influenced. inflammatory and / or infectious processes such as periodontal disease, caries, or even joint problems such as temporomandibular joint dysfunction can affect performance or impair participation in training and competitions.

the objective of this longitudinal clinical study will be to evaluate the effect of dental treatment on individuals who practice physical activities through physical parameters of strength, speed and resistance. according to an initial survey, about 120 individuals should be examined. clinical parameters such as decayed, lost and / or filled dental index and periodontal parameters such as probing depth (ps), clinical level of insertion (nci), plaque index (ip) and bleeding index (is) will be evaluated . physical tests of strength, speed and resistance should be performed and periodontal therapy should be performed according to the needs presented by each individual. after 90 days, new clinical examinations and physical tests should be performed. the results obtained should be tabulated and analyzed. the investigators believe that individuals with oral inflammation / infection, the physical performance should be higher after performing periodontal therapy. pro inflammatory cytokines present in high concentrations in the presence of periodontal disease can influence fatigue and difficulty in recovering from injuries, variables so important in an athlete's life.

Eligibility criteria:
inclusion criteria: * athletes from all sports, * individuals with systemic pathologies, smokers, should be included in the study exclusion criteria: * pregnancy or lactation, use of antibiotics in the last 3 months, phenytoin, calcium antagonists, cyclosporine or anti-inflammatory drugs one month before the initial consultation, use of oral or replacement contraceptives hormonal, periodontal treatment in the 6 months prior to the start of the study.

Keywords: periodontal diseases athletes caries, dental periodontal index
68ga-fapi-46 pet/ct scan in imaging patients with sarcoma

Conditions: Metastatic Sarcoma; Recurrent Sarcoma; Sarcoma

Summary: this early phase i trial studies an imaging technique called 68ga-fapi-46 pet/ct to determine where and to which degree the fapi tracer (68ga-fapi-46) accumulates in normal and cancer tissues in patients with sarcoma. pet is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 68ga-fapi. because some cancers take up 68ga-fapi it can be seen with pet. ct utilizes x-rays that traverse body from the outside. ct images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient's body.

primary objective: i. to define the biodistribution of gallium ga 68 fibroblast activation protein inhibitor (fapi)-46 (68ga-fapi-46) in normal and cancer tissues of patients with sarcoma with histopathology validation. secondary objectives: i. to evaluate whether 68ga-fapi-46 accumulation observed by positron emission tomography (pet) reflects geography, extent and degree of fap expression determined by immuno-histochemistry (ihc). ii. to assess the 68ga-fapi-46 biodistribution correlation with fludeoxyglucose f-18 (18f-fdg) biodistribution and to define the frequency of the following phenotypes (fap positive \[+\]/ fdg+, fap negative \[-\]/ fdg+, fap+/ fdg-, fap-/ fdg-). iii. 3. to determine fap expression profile and identify activating and loss of function mutations and gene rearrangement in available tumor tissue samples from patients with localized or metastatic sarcoma using rna sequencing outline: patients receive 68ga-fapi-46 intravenously (iv), and then undergo pet/computed tomography (ct) over 20-90 minutes. on another day, patients receive 18f-fdg and then undergo pet/computed tomography (ct) according to standard of care procedures (if applicable).

Eligibility criteria:
inclusion criteria: * patients who are scheduled to undergo surgical excision or biopsy of a suspected sarcoma primary, or a suspected recurrent or metastatic lesion. * patients who are ≥ 18 years old at the time of the radiotracer administration. * patients who can provide written informed consent. * patients who are able to remain still for duration of imaging procedures (up to one hour for each). exclusion criteria: * patient is pregnant or nursing. * patients with any new cancer therapy between the baseline 18f-fdg pet/ct and the investigational fapi pet/ct * patient has underlying disease which, based on the judgment of the investigator, might interfere with the collection of high quality data.
prospective evaluation of facial cosmetic procedures

Conditions: Cosmetic Techniques

Summary: a prospective, trial to quantitatively and qualitatively compare the dermal fillers for the treatment of age related aesthetic changes.

dermal fillers have been approved for the treatment of age related aesthetic changes, including facial volume loss, and attenuation of the static and dynamic rhytid. despite widespread use of volumizing fillers there is little data quantifying the subjective benefit of these minimally invasive treatments from the patient perspective. furthermore, there is little data comparing the subjective benefit with true objective volumetric results. such data will provide much needed information for patient counselling and treatment optimization for patient perceived outcomes. this study is to determine the patient reported outcomes of three different dermal fillers and establish the volumetric changes over 90 days. screening will be performed during the patient's office visit. approximately 100 patients will be enrolled. patients will participate up to 90 days (day 1, 14 days, 28 days, and 90 days).

Eligibility criteria:
inclusion criteria: * female patients 40 - 65 years of age exclusion criteria: * male patients * prior surgical facial rejuvenation procedures * facelift * neck lift * blepharoplasty * facial fat grafting * prior minimally invasive rejuvenation procedure ≤ 12 months * known contraindications to devices or drugs used in this study * facial paralysis * congenital facial asymmetry * pregnant women * patient actively taking blood thinners

Keywords: facial filler retylane aesthetic improvement volumizing fillers
tarka vs. hyzaar in patients with metabolic syndrome (star)

Conditions: Hypertension; Metabolic Syndrome

Summary: the primary objective of this study is to determine whether impaired glucose tolerance is improved to a greater degree by tarka than hyzaar in subjects with metabolic syndrome


Eligibility criteria:
inclusion criteria: * metabolic syndrome * fasting blood glucose between 100 mg/dl and 125 mg/dl * hypertension * one additional criteria, exclusion 1 exclusion criteria: * subject has a current diagnosis of type 1 or type 2 diabetes mellitus. * subject has a hypersensitivity to ace inhibitor, arb, ccb, clonidine, methyldopa, hydralazine, or thiazide diuretic medication.

Keywords: hypertension metabolic syndrome tarka hyzaar
effect of #lifegoals on adolescents' mental health

Conditions: Well-being; Life Style, Healthy; Resilience; Depressive Symptoms

Summary: the aim of this study is to evaluate the effectiveness of the #lifegoals intervention for promoting mental health in early adolescents.

the aim of the mov-e-star project is to promote mental health in early adolescents (12-15 years) by motivating them to adopt a healthy lifestyle. adolescents can protect their mental health by increasing physical activity, reducing sitting time, getting sufficient sleep, and taking a daily breakfast. targeting these healthy lifestyle behaviours in young adolescents is an empowering, low-threshold approach that can create large public health effects. the mov-e-star project aims to meet the need for an intervention targeting these behaviors in the adolescent population. therefore, the mobile intervention '#lifegoals' was developed in collaboration with stakeholders and users. the theory-based intervention consists of an application that includes (a) a self-regulation component for goal setting, self-monitoring and feedback, (b) a narrative in the form of short episodes from a youth daily drama for modelling, attitude change and increased engagement, and (c) an automated chat-function for social support and sustained engagement with the intervention. the current study will test the intervention in a group-randomized controlled trial for its effects on mental well-being. participants in the intervention group will have the #lifegoals intervention installed on their phone and will be asked to use the intervention for 12 consecutive weeks. participants in the control group will not receive an intervention but will only participate in the measurements. outcomes will be assessed at baseline, intermittent (7 weeks after baseline) and post (13 weeks after baseline). measures will include smart wearables and surveys.

Eligibility criteria:
inclusion criteria: * general adolescent population in first, second and third year of belgian secondary education * attending regular secondary education in a school in flanders, belgium, at time of data collection * good understanding of dutch exclusion criteria: * attending special needs education schools; * attending education for non-dutch speakers.

Keywords: mhealth mental well-being adolescent digital behavior change intervention healthy lifestyle
alcohol consumption and stress at patients alcohol-dependants

Conditions: Alcohol Dependence

Summary: this 3 weeks study examines the correlation between stress and alcohol using an ecological, prospective design.

this 3 weeks study examines the correlation between stress and alcohol using an ecological, prospective design. participants will be given phone calls 4 times a day for 3 weeks, assessing perceived stress and alcohol related craving.

Eligibility criteria:
inclusion criteria: * males or females aged 18-65 years * alcohol use disorder defined by dsm 5 criteria * fluent in french * hospitalized for alcohol withdrawal for at least 7 days * viable (working) telephone number exclusion criteria: * participants without social care insurance * any dsm axis i disorder not defined in the inclusion criteria * mandatory psychiatric treatment

Keywords: alcohol dependence stress- correlation genetic crhr1
clinical trial to evaluate three systems of osteosynthesis for fixation of olecranon osteotomies in adults

Conditions: Olecranon Fracture

Summary: surgery of the elbow joint is often made difficult by the highly constrained nature of the elbow joint. this is why it is often necessary to perform an osteotomy of the olecranon, the proximal part of the ulna, which allows perfect exposure of the entire articular surface. after performing the osteotomy, access to the joint is obtained, the articular problem is solved as appropriate and, upon completion, the osteotomized bone is fixed with a stable fixation system that allows the osteotomy to heal without problems. it is a safe, reproducible procedure that is associated with low associated morbidity. the main problems associated with this procedure are the lack of consolidation of the osteotomy or the need for removal of the osteosynthesis material at a later stage.

the incidence of these complications is around 4% for the former and 20-50% for the latter. both complications usually require a second surgical procedure to solve the problem, so the reoperation rates for these procedures are around 40-50%. however, there is discussion in the literature as to the most appropriate fixation system to ensure fracture healing. there are, broadly speaking, three frequently used fixation systems: the placement of two steel pins and a wire in an obenque configuration, the placement of a screwed plate or the placement of a compression screw. it is not clear which is the best fixation system among these three. biomechanical studies suggest that, from this point of view, all three procedures are adequate. the choice of which is ideal should therefore be based on the ease of use and the complications associated with the procedure, in particular the reoperation rate.there are no clinical trials in the literature comparing these three fixation techniques, so there is a clear lack of knowledge in this field.

Eligibility criteria:
inclusion criteria: * patients who, after receiving information about the design, the purposes of the study, the possible risks that may arise from it and the fact that they may refuse to collaborate at any time, give their written consent to participate in the study. * be over 18 years of ag * have an elbow disorder that is to be treated surgically through an olecranon osteotomy approach. * that the olecranon osteotomy is amenable to synthesization with the three proposed systems. * understand the purpose of the study and be available for routine hospital visits. exclusion criteria: * patients who have undergone ipsilateral elbow surgery. * presence of ulnar fractures * patients with an active infection at any site at the time of elbow surgery. * inability to understand the procedure or information related to the study.
mingo supplemental trial in x-linked dystonia-parkinsonism patients

Conditions: X-Linked Dystonia Parkinsonism

Summary: to see whether mingo, a food supplement, will be able to lessen the drastic weight loss seen among x-linked dystonia parkinsonism patients.

x-linked dystonia parkinsonism (xdp, formerly known as dyt3) occurs primarily in filipino males and is characterized by neurodegenerative dystonia and parkinsonism. it is currently recognized to have wide phenotypic variability relating to age of onset, location of disease onset and rate of severity/disease progression. most patients begin with focal dystonia that generalizes with the development of parkinsonism later in disease course. xdp patients suffer from severe nutritional loss due to symptoms such as dysphagia, loss of appetite, and consistently high metabolic requirements brought about by their movement disorder. approximately 79% of patients with xdp have experienced rapid weight loss since the onset of their disease. it is the aim of the researchers to assess the clinical usefulness of adding a nutritional supplement to the daily dietary needs of these patients. mingo is a supplement consisting of local ingredients such as moringa, rice and mung beans, which can be added to any type of edible paste, food, and liquid. mingo has gained popularity as an emergency food in disaster relief operations due to the ease of its preparation, its high nutritional value and relatively low price. for the last two years, it has also been used as an agent for nutritional build up in malnourished populations of children. this study will provide valuable information on whether patients with xdp can increase their weight by consuming mingo, which will lead to improvements in the patients' medical care and wellbeing.

Eligibility criteria:
inclusion criteria: * subject is above the age of 18 * positive diagnosis of xdp by movement disorder specialist/fellow * subject with a yes response to a "supportive home environment" in the patient's most recent "doctors monthly report" * subject are easily accessible to passable roads and pubic transportation exclusion criteria: * subjects who have extreme movements that prevent staff from performing bmi or muac measurements * subjects who have abnormal metabolic labs prior to the start of the study * subjects who are taking pharmacological or medicinal supplements that may effect weight * subjects who have been hospitalized within the last 2 weeks from the start of the trial * subjects who have a nasogastric tube or g-tube * subjects with a history of other diseases that my effect weight (eg: hypo/hyperthyroidism)

Keywords: prospective randomized trial