Kornimate/medical-research-clean huggingface dataset:
mri study of changes in blood-brain/tumor-barrier permeability in patients with brain metastases during and after radiotherapy

Conditions: Brain Metastases

Summary: this study aims to assess changes in vascular permeability in the brain tumor, and in the surrounding brain, due to radiation therapy, using magnetic resonance imaging (mri).


Eligibility criteria:
inclusion criteria: * patients with a histological confirmed malignancy and presence of intraparenchymal brain metastases * patients are treated by wbrt, srs, or fsrt * age greater than or equal to 18 years * a life expectancy of greater than or equal to 8 weeks * karnofsky performance status (an assessment of general well being and ability to do activities of daily living; scale ranges from 0 to 100 where 100 is perfect health) greater than or equal to 60 * informed consent with signed study-specific informed consent form exclusion criteria: * major medical or psychiatric illness, which, in the investigator's opinion, will prevent completion of the protocol * patients with lepto-meningeal metastases documented by magnetic resonance imagine (mri), computed tomography (ct), or cerebrospinal fluid (csf) evaluation * for patients that will undergo whole brain radiation therapy (wbrt), previous wbrt is not allowed. patients who have had brain metastases managed by stereotactic radiosurgery (srs), fractionated stereotactic radiation therapy (fsrt), or surgery are eligible * for patients that will undergo stereotactic radiosurgery (srs), previous whole brain radiation therapy (wbrt) within 5 months prior to study entry is not allowed. prior stereotactic radiosurgery (srs), fractionated stereotactic radiation therapy (fsrt), or surgery is allowed if current treatment will be for a lesion(s) not previously treated. * for patients that will undergo fractionated stereotactic radiation therapy (fsrt), previous whole brain radiation therapy (wbrt) within 5 months prior to study entry is not allowed. prior stereotactic radiosurgery (srs), fractionated stereotactic radiation therapy (fsrt), or surgery is allowed if current treatment will be for a lesion(s) not previously treated. * patients unable to undergo or tolerate mri scans (presence of cardiac pacemaker, implanted cardiac defibrillator, aneurysm clips, etc). * patients should have no contraindications to having a contrast enhanced magnetic resonance imaging (mri) scan. these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the university of michigan. * women who are pregnant are excluded.
the study of kn046 in combination with lenvatinib in advanced hepatocellular carcinoma

Conditions: HCC

Summary: this ia a single-arm, not-randomized, open-label phase ii study. the purpose of this study is to evaluate the safety and efficacy of kn046 (pd-l1 /ctla-4 bispecific antibody) combined with lenvatinib(tki) for the treatment of advanced hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: * has a diagnosis of hepatocellular carcinoma confirmed by histology or cytology； * barcelona clinic liver cancer (bclc) stage b or c； * age ≥18 years or ≤75 years for both genders； * ecog performance status: 0-1； * child pugh score≤7； * lvef≥50% or above lln of the research institution； * enough organ function； * has at least one measurable lesion based on recist 1.1； * life expectancy ≥3 months； * patients must be able to understand and willing to sign a written informed consent document； exclusion criteria: * fibrous lamina hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma, cholangiocarcinoma etc; * tumor thrombus invasion at the main portal vein (vp4), inferior vena cava or heart involvement; * subjects who have previously received immune checkpoint inhibitors (such as anti-pd-1/l1, ctla-4, etc.); * subjects who have received liver local treatment (transcatheter chemoembolization, transcatheter embolization, hepatic artery perfusion, radiotherapy, radioembolization or ablation) within 4 weeks before administration; * subjects who need corticosteroids or immunosuppressive agents for systemic therapy; * any previous or current active autoimmune disease or history of autoimmune disease; * history of hepatic encephalopathy or liver transplantation; * history of interstitial lung disease or non-infectious pneumonia; * history of allergic reactions to related drugs; * clinically obvious gastrointestinal abnormalities, which may affect the intake, transport or absorption of drugs (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.), or patients undergoing total gastrectomy; * with serious systemic diseases such as heart disease and cerebrovascular disease, and the condition is unstable or uncontrollable; * subjects with clinically significant gastrointestinal bleeding or thrombosis or embolic events within 6 months; * untreated hepatitis infection: hbv dna\>2000iu/ml or10000 copies/ml, hcv rna\> 1000copy/ml, both hbsag and anti-hcv body are positive; * evidence of active pulmonary tuberculosis (tb); * positive test of immunodeficiency virus (hiv) or acquired immunodeficiency syndrome (aids); * pleural effusion, ascites and pericardial effusion with clinical symptoms or needing drainage;
chronic fatigue following acute epstein-barr virus infection in adolescents

Conditions: Fatigue Syndrome, Chronic; Epstein-Barr Virus Infections

Summary: chronic fatigue syndrome (cfs) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. epstein-barr virus (ebv) infection might precipitate cfs. in this study, 200 adolescents undergoing acute ebv infection will be followed prospectively, and also compared with a group of healthy controls. the aim is twofold: * to identify factors that predispose to chronic fatigue among adolescents with acute ebv infection * to compare pathophysiological features of patients with acute ebv infection with a group of healthy controls. possible risk factors for chronic fatigue 6 months after ebv-infection includes: * severity of the initial infection * immune responses characteristics * characteristics of the neuroendocrine stress response * cognitive functioning * emotional disturbances * genetics/ epigenetics of candidate genes * certain personality traits * critical life events


Eligibility criteria:
inclusion criteria: * age ≥ 12 years and \< 20 years * serological confirmation of acute ebv infection * lives in one of the following norwegian counties: oslo, akershus, buskerud, østfold, vestfold exclusion criteria: * medical treatment for another disease (hormonal conterception and antibiotics against tonsillitis/pharyngitis are accepted) * pregnancy * debut of illness \> 6 weeks ago
fetal endoscopic surgery for spina bifida

Conditions: Neural Tube Defects; Spina Bifida, Open; Myelomeningocele; Fetal Disease; Hydrocephalus; Chiari Malformation Type 2; Congenital Abnormality; Surgery; Maternal, Uterus or Pelvic Organs, Affecting Fetus

Summary: this study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.

introduction: spina bifida is a congenital malformation characterized by a failure in neural tube closure. unprotected fetal neural tissue at the spine level undergoes not only progressive neurodegeneration in spinal cord, but also the impairment in brain development, hindbrain herniation or chiari ii malformation probably due to pressure disturbances resulting from a continuous leakage of cerebrospinal fluid through the defect. the neurological consequences at birth are irreversible and sometimes devastating, including paraplegia, sphincter urinary and fecal incontinence, hydrocephalus, cranial nerve disturbances, respiratory problems and death due to spinal cord injury and brain maldevelopment. intrauterine fetal open repair of the defect has proved to improve hindbrain herniation and decrease the need of cerebrospinal shunting. hypothesis: the investigators hypothesize that minimally invasive surgery of spina bifida is feasible and may minimize surgical aggression and obstetrical complications, with similar neonatal and neurological results. intervention: in this study the investigators propose a fetoscopic skin closure technique. after a maternal laparotomy the uterus is exteriorized, the amniotic cavity is accessed by fetoscopic approach. the placode is dissected from the surrounding tissue and dropped into the opened spinal canal, untethered. part of the cystic tissue is resected. the edges are then closed to the midline. follow up: after surgery patients are followed up at the fetal medicine unit every one or two weeks. the mode of delivery is decided according to obstetric criteria. neonates will be examined at birth, and followed up regularly at least until 30 months. patients are lifetime followed up by our multidisciplinary myelomeningocele (mmc) committee that comprises professionals from the spina bifida unit, neonatologists, pediatric surgeons, pediatric urologist, pediatric orthopedic surgeons, radiologists, rehabilitation, pathologists, pediatric neurosurgeons, obstetricians and fetal therapists.

Eligibility criteria:
inclusion criteria: * maternal age \> 18 years old * singleton pregnancy * gestational age between 18 0/7 weeks and 26 6/7 weeks * isolated neural tube defect between t1 and s1 * cerebellar herniation (chiari type ii) exclusion criteria: * fetal anomalies non related to neural tube defect (ntd) including chromosomal abnormalities * body mass index \> 35 kg/m2 * maternal disorders contraindicating surgery * genetic anomalies with poor prognosis * sever kyphosis (\>30º)
clinical efficacy of different remineralizing agents in treatment of white spot lesions

Conditions: Remineralization

Summary: the aim of the present study is to evaluate the efficiency of self-assembling peptide p11-4, tricalcium phosphate fluoride varnish, 5% f- and 5% fluoride varnish in remineralization of wsls in primary dentition among a group of egyptian children.


Eligibility criteria:
inclusion criteria: * apparently healthy cooperative children * aging from 3-5 years old child * both genders * primary teeth with active wsls on buccal or labial surfaces * patient and parent acceptance to treatment and maintenance of good oral hygiene exclusion criteria: * restored teeth * white spot lesions due to fluorosis * teeth with hypoplasia * lesions that require an invasive treatment * any pathology or concomitant medication affecting salivary flow or causing dry mouth
clinical implications of fetal positioning during delivery

Conditions: Fetal Position and Presentation Abnormalities

Summary: the project aims to find a relationship between the positioning of the foetus before and during birth and the results of obstetrics and to determine their incidence in the polish population. the study will be conducted by combining the use of ultrasound diagnostics, midwives observations during childbirth, analysis of medical documentation and a questionnaire on the activity of examined women. the obtained results will be used to prepare guidelines for the birth in a particular foetus position.

the purpose of the examination is to describe the difficulties associated with delivery in a non-optimal position of the fetus. initial observations show that such childbirth is perceived as difficult by both the women giving birth and the staff. the aim of the study is to describe the level of difficulty of this labor, expressed as the experience of the woman, as well as all the elements that may affect the difficulty of this labor, for example, slower or no progress in labor, disturbances in systolic function, injuries, the need to use epidural anesthesia, increased blood loss.

Eligibility criteria:
inclusion criteria: * during childbirth, * in a single pregnancy, exclusion criteria: * pelvic position of the fetus * in whom labor is induced for reasons other than post-term pregnancy, * women who came to the hospital in the second stage of labor * severe diseases mother or foetus.

Keywords: fetal malposition fetal left occiput position fetal right occiput position
treatment of patients with active neurocysticercosis in eastern africa

Conditions: Neurocysticercosis

Summary: this multi-centre prospective cohort study of symptomatic patients with active neurocysticercosis (ncc) aims to identify factors related to treatment success of anthelmintic therapy. neurological symptom/sign and cyst resolution, quality of life, accuracy and performance of serological t. solium diagnostics and ncc-specific immunological parameter will be followed up at multiple time points in the study. the final assessment will be done six months after the end of anthelmintic treatment. this study aims to guide treatment of ncc in sub-saharan africa by identifying factors that are associated with treatment outcomes. the factors that cause some people to fail complete resolution of all cysts and/or symptoms/signs are unknown.


Eligibility criteria:
inclusion criteria: * all patients will be included who * meet the definitions of active ncc * have epilepsy, epileptic seizures or chronic/severe progressive headaches * are physically and mentally fit enough for treatment * are willing to be hospitalized and to receive the standard treatment for ncc * are willing to participate a follow-up for six months * are willing and able to consent to this study, with consent recorded on a signed consent form exclusion criteria: * potential participants who will not meet the above inclusion criteria will be excluded. * women who are pregnant will not be included, but re-evaluated for inclusion into the study after they have given birth. * potential participants who are currently taking or have taken albendazole, praziquantel, or a corticosteroid within the past 12 months will be excluded. * people with uncontrolled hypertension and/or diabetes will be excluded from the study but will be re-evaluated for inclusion once their hypertension and/or diabetes have been treated. * people with chronic consuming illness such as cancer and those with mental handicap severe enough to not allow them to follow the study instructions or reliably take their medication will be excluded. * children aged \<10 years.
chatbot for depression, anxiety, and eating disorders

Conditions: Depression; Anxiety; Eating Disorders

Summary: the research team would like to test how efficacious an artificial intelligence chatbot is in delivering supportive behavioral interventions in populations with anxiety, depression, or eating concerns.

the research team has developed a deep learning-powered application that can provide support and therapeutic suggestions via natural dialogue. the chatbot is designed to be highly scalable such that it could address access issues (to address the majority of persons who do not not have access to therapy). eventually, it is hoped this intervention can provide accessible therapy for those with anxiety, depression, and eating disorders, among other mental illnesses. the chatbot has been trained with intervention-oriented text conversations written by research assistants, employing a variety of therapeutic techniques, including cognitive-behavioral therapy. the research team hopes to test how well the chatbot can respond and aid those with mental health symptoms. the chatbot's effectiveness will be monitored based on the participants' interactions with the chatbot, as well as the participants' scores on the phq-9, gad-iv, swed, and general satisfactory questionnaires.

Eligibility criteria:
inclusion criteria: * we will recruit participants online using facebook, google ads, reddit, mturk, listservs, and other online platforms. * these individuals must meet the criteria for anxiety, depression or disordered eating, according to the phq-9, gadq-iv, and swed 3.0. exclusion criteria: * individuals currently being treated for active suicidality (measured with c-ssrs), bipolar i/ii, and active psychosis will be excluded from the study.
long-term postoperative outcomes after bilateral congenital cataract surgery in eyes with microphthalmos

Conditions: Microphthalmos With Congenital Cataracts

Summary: cataract surgery in infantile eyes, which are microphthalmic, can be even more demanding. in addition, the frequent presence of other ocular and systemic anomalies such as nystagmus, glaucoma, amblyopia, and higher rate of postoperative complications may limit the success of cataract surgery. in our previous study, the investigators examined the intraoperative performance and postoperative outcomes of bilateral cataract surgery in microphthalmic eyes of patients before their first birthday. at 1 year, the postoperative results showed that good visual outcomes could be obtained in microphthalmic eyes. since only a few studies have reported outcomes, and that too only short term of cataract surgery on microphthalmic eyes, in this prospective observational study we evaluated the long-term impact of bilateral cataract surgery on eyes with microphthalmos. the investigators examined the outcomes, complication rates, influence of age at surgery on pattern of axial growth and central corneal thickness and visual and orthoptic assessment in these eyes.


Eligibility criteria:
inclusion criteria: * presence of microphthalmos and congenital cataract. * microphthalmos was defined as an eye with an axial length (al) that is more than 2 sd smaller than the normal for that age group according to gordon and donzes exclusion criteria: - children with congenital anomalies such as posterior persistent fetal vasculature causing stretching of the ciliary processes or a tractional retinal detachment, aniridia, and chorioretinal coloboma were excluded.
platelet rich plasma and recurrent implantation failure

Conditions: Recurrent Implantation Failure

Summary: this study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure. the study population consisted of infertile women with a history of recurrent implantation failure who had failed to achieve a clinical pregnancy which at least four good quality embryos transfers and are now candidate for ivf-icsi or freeze embryo transfer cycles with and without intra uterine infusion of platelet rich plasma in reproductive biomedicine research center, royan institute, tehran iran.

platelet rich plasma (prp) is a blood product with a high platelet and a normal plasma fibrinogen level. given the effective factors of rpr in repairing damaged tissues, its application in the field of regenerative medicine has widely been interested over the last three decades. according to the literature, prp is an effective and safe treatment in the fields of orthopaedics, dermatology, ophthalmology, and repair of neurological, vascular, and connective tissue damage, but its application in the field of infertility is limited to a few pilot studies in which the effects of prp on endometrium and recurrent implantation failure (rif) were investigated. given the importance of endometrial compliance and according to molecular studies, which indicate that endometrial growth factors in women with a history of rif are lower than normal fertile women, prp, along with other existing strategies, can be used to improve endometrial compliance in patients with a history of rif. the present randomized, controlled clinical trial is proposed to determine the efficacy of prp in the treatment of patients with rif in the cycles of ivf-icsi and frozen embryo transfer at royan institute.

Eligibility criteria:
inclusion criteria: 1. infertile women with a history of recurrent implantation failure who had failed to achieve a clinical pregnancy which at least four good quality embryos transfers 2. 20\<age\<40 3. 19\<bmi\<29 4. non endocrine, hematologic and autoimmune disorders 5. non chromosomal and genetic abnormalities 6. non uterine anomalies, surgical history, endometriosis, adenomyosis, hydro salpinx, uterine fibroids, polycystic ovary syndrome 7. having at least three good quality embryos exclusion criteria: 1. cervicitis 2. recent fever condition 3. use of corticosteroids (in up to 2 weeks before the procedure) or non-steroid anti-inflammatories (in up to 48 hours before procedure) 4. anemia, thrombocytopenia, platelet dysfunction syndrome, hypofibrinogenemia 5. septicemia, active infections with pseudomonas, klebsiella or enterococcus 6. history of cancer 7. patient's tendency for withdrawal

Keywords: platelet rich plasma recurrent implantation failure infertility assisted reproduction technology
healthy bellies - intervention program during pregnancy on women and newborn

Conditions: Lifestyle; Physical Activity; Dietary Habits; Depressive Symptoms

Summary: "healthy bellies" is an intervention program with pregnant women, based on the promotion of healthy lifestyles. it aims to evaluate the impact of the program in the health of both pregnant and newborn. this trial is being conducted with pregnant women, divided into control and intervention group. are performed 3 assessment periods: 1 - beginning of the program; 2 - postpartum; 3 - 1 month after delivery. the intervention group has a program of 3 weekly physical exercise classes and the control group has the basic information that is usually provided by health professionals. with this program, it is expected to contribute with evidence to the best practice in the field of interventions in pregnancy and improve health outcomes of both pregnant and newborn.


Eligibility criteria:
inclusion criteria: * do not have any medical or obstetric contraindication for physical exercise exclusion criteria: * haemodynamically significant heart disease; * restrictive lung disease; * incompetent cervix/cerclage; * multiple gestation at risk for premature labor; * persistent second or third trimester bleeding; * placenta praevia after 26 weeks gestation; * premature labor during the current pregnancy; * ruptured membranes; * pregnancy induced hypertension; * severe anaemia; * unevaluated maternal cardiac arrhythmia; * chronic bronchitis; * poorly controlled type i diabetes; * extreme morbid obesity; * extreme underweight (body mass index \<12); * history of extremely sedentary lifestyle; * intrauterine growth restriction in current pregnancy; * poorly controlled hypertension/pre-eclampsia; * orthopaedic limitations; * poorly controlled seizure disorder; * poorly controlled thyroid disease; heavy smoker).

Keywords: pregnancy physical activity newborn depressive symptoms dietary habits healthy lifestyles
extension study to assess the long-term safety of tegaserod in women with symptoms of dyspepsia

Conditions: Dyspepsia

Summary: this study is being done to evaluate the long-term safety of tegaserod in women with symptoms of dyspepsia who have completed the core study. tegaserod will be evaluated at 6 mg twice daily.


Eligibility criteria:
inclusion criteria: * female, 18 years and older * fulfilled eligibility criteria in chtf919d2301 (double blind study) and successfully completed the double-blind study exclusion criteria: - early discontinuation from the double-blind study other protocol-defined inclusion/exclusion criteria may apply

Keywords: dyspepsia, gastrointestinal, tegaserod
prediction of hypotension after spinal anesthesia in cesarean sections using non-invasive measurement methods

Conditions: Postspinal Hypotension

Summary: to compare the incidence of hypotension after spinal anesthesia and the values of perfusion index, pleth variability index, tissue oxygen saturation and tissue hemoglobin index between those who developed hypotension and those who did not develop hypotension over time.


Eligibility criteria:
inclusion criteria: * those who underwent elective cesarean section over the age of 18, * american society of anesthesia i and ii, * agree to participate in the study, exclusion criteria: * \ 45 years, * preeclampsia, * cardiovascular disorders, * fetal abnormalities, * not undergoing spinal anesthesia or undergoing general anesthesia during surgery, * not agreeing to participate in the study