Kornimate/medical-research-clean huggingface dataset:
open trial of trauma-focused psychodynamic psychotherapy for people living with hiv and ptsd

Conditions: Post Traumatic Stress Disorder; HIV

Summary: people living with hiv (plwh) have a higher rate of post-traumatic stress disorder (ptsd) diagnosis than the general population. comorbid ptsd is also associated with negative hiv-related health outcomes. unfortunately, little outcome research has examined the usefulness of ptsd treatments for ptsd. this pilot study adapts for plwh a non-exposure based psychotherapy for ptsd focused on reflecting on one's emotions and relationships and understanding and working through how trauma may have disrupted them. the study team is interested in better understanding the needs of plwh with ptsd, learning whether plwh with ptsd find this treatment acceptable and helpful, and beginning to understand the relationship between hiv-related health factors (e.g., inflammation and stress biology) and ptsd, and how these health factors may improve during treatment.


Eligibility criteria:
inclusion criteria: * diagnosis of dsm-5 defined ptsd, per the clinician administered ptsd scale \& caps-5 total severity score greater than or equal to 25 * hiv diagnosis (by medical records or hiv testing) * stable psychiatric/psychotropic medication for \>=2 months and ongoing during treatment exclusion criteria: * psychosis * bipolar i * acute suicidality * current substance use disorder * organic mental syndrome or intellectual disability * unstable non-hiv medical conditions

Keywords: ptsd hiv psychotherapy trauma
social media intervention to stop nicotine and cannabis vaping among adolescents

Conditions: Vaping

Summary: social media based intervention to support teens in their efforts to quit vaping.

this study is a randomized controlled trial of a social media intervention to support teens in their efforts to quit vaping.

Eligibility criteria:
inclusion criteria: 1. english literacy 2. age between 13-21 years 3. indicate they use social media "most" (\>= 4) days per week 4. have vaped at least once per week in the past 30 days (90 percent of participants) 5. access to a computer or mobile phone with photo capability to verify abstinence from vaping 6. indicate they are considering quitting or are interested in quitting with the next 6 months or within the next 30 days 7. currently reside in california exclusion criteria: 1. no english literacy 2. age under 13 or over 21 3. insufficient social media use (3 or fewer days per week) 4. have not vaped at least once per week in past 30 days 5. no access to computer or mobile phone with photo capability to verify abstinence from vaping 6. not considering or interested in quitting vaping in the next 30 days or 6 months; 7. not a california resident

Keywords: nicotine dependence social media
the effectiveness of home-based walking program in improving quality of life in patients with hemodialysis

Conditions: Hemodialysis

Summary: this study will investigate the effectiveness of a rehabilitation program in improving physical functioning, cardiovascular health index, negative emotions, and quality of life in patients with hemodialysis in taiwan. hypothesis: 1. the quality of life in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, and 24th month. 2. the negative emotions in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, and 24th month. 3. the cardiovascular health index in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, and 24th month. 4. the physical functioning in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, and 24th month.

this study will investigate the effectiveness of a rehabilitation program in improving physical functioning, cardiovascular health index, negative emotions, and quality of life in patients with hemodialysis in taiwan.

Eligibility criteria:
inclusion criteria: -patients with hemodialysis who were aged ≥20 years, could communicate in either mandarin or taiwanese, 6-minute walking test ≧ 300m and not cognitively impaired were included. exclusion criteria: -
comparing the efficacy of 10-day reverse hybrid therapy and 10-day triple therapy plus bismuth therapy.

Conditions: Helicobacter Pylori Infection

Summary: reverse hybrid therapy achieves a higher eradication rate than triple therapy plus bismuth therapy remains unanswered.

with the rising prevalence of antimicrobial resistance, the failure rate of the 7-day standard triple therapy has declined to unacceptable level (\<80%) worldwide. several regimens were suggested to replace standard triple therapy in the area with high clarithromycin resistance, including sequential therapy, concomitant therapy, hybrid therapy and bismuth containing quadruple therapy. a 14-day hybrid therapy invented by our study group appears very promising in h. pylori eradication, achieving eradication rates of 95%. a clinical trial by hsu et al from our hospital showed 12-day reverse hybrid therapy also achieved high eradication rate, and improved the compliance of patients. even prolong the treatment duration of standard triple therapy from 7 days to 12 days, the efficacy of eradication was still \< 90% (85-88%). the limitation of triple therapy in against resistant-stains was still existed. the addition of bismuth (triple therapy plus bismuth) can improve cure rates despite a high prevalence of antimicrobial resistance. the major bismuth effect is to add an additional 30%-40% to the success with resistant infections. however the direct compare the efficacy between 10-day reverse hybrid therapy and 10-day triple therapy plus bismuth is still insufficiency in taiwan and worldwide. choosing a navel therapy or a modifying triple therapy can get better efficacy, it is remained to be determined. besides genotyping polymorphism of cyp2c19 influenced the metabolism of proton pump inhibit, and could cause decreasing of eradication rate of standard triple therapy. but the influence in 10-day reverse hybrid therapy and 10-day triple therapy plus bismuth is unclear.

Eligibility criteria:
inclusion criteria: * consecutive h pylori-infected outpatients, at least 20 years of age, with endoscopically proven peptic ulcer diseases or gastritis exclusion criteria: * previous h pylori-eradication therapy * ingestion of antibiotics or bismuth within the prior 4 weeks * patients with allergic history to the medications used * patients with previous gastric surgery * the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia) * pregnant women

Keywords: helicobacter pylori eradication rate
contralateral testicular volume in unilateral impalpable testis

Conditions: Pediatric ALL

Summary: this prospective interventional study aimed at the preoperative sonographic estimation of the testicular volume of the normal side in case of contralateral impalpable maldescended testis in order to predict the condition of the diseased side and hence the need for diagnostic laparoscopy.

purpose: this study aimed at the evaluation of the value of the estimated volume of a normal testis to predict the status of its contralateral impalpable side and hence decide the importance of laparoscopic exploration. material \& methods: patients with unilateral impalpable maldescended testis - as confirmed by clinical and sonographic examination- were enrolled in this prospective interventional study between november 2018 and august 2022 at elshatby university hospital, faculty of medicine, alexandria university. the volume and three-dimensional diameter of the normal contralateral testis were measured by the pre-operative us using the formula: volume = l x w x h x π/6, where l is the length, w is the width, h is the height, and was correlated with the intra-operative laparoscopic findings.

Eligibility criteria:
inclusion criteria: * pediatric patients with unilateral impalpable maldescended testis exclusion criteria: * patients with bilateral impalpable maldescended testis and those with post-operative ascended testis

Keywords: impalpable testis volume ultrasound
an intervention study to increase physical activity and maternal well-being during pregnancy

Conditions: Pregnancy; Depression

Summary: to refine, implement and evaluate a motivationally-tailored exercise intervention for increasing physical activity and mental health during pregnancy and the postpartum.

pregnancy appears to pose a further barrier to exercise, as women remain inactive or cease to exercise all together. yet, regular physical activity during pregnancy in healthy women has been shown to be safe and positively associated with physical and psychological health benefits. to date interventions to promote physical activity have not targeted pregnant women. we are proposing to pilot the first study to evaluate a theory-derived intervention designed to promote physical activity during pregnancy. we anticipate that pregnant women assigned to the motivationally-tailored exercise intervention will show a significant increase in physical activity from baseline at the post-treatment follow-up (32 weeks gestation). we expect that the motivationally-tailored intervention will positively influence physical and mental health status during pregnancy.

Eligibility criteria:
inclusion criteria: * pregnant exclusion criteria: * regular participation in moderate intensity exercise for at least 30 minutes, 3 or more times a week at the time of study entry * contraindications for participating in exercise during pregnancy as outlined by the sogc/csep clinical practice guidelines * inability to communicate in either english or french.

Keywords: pregnancy, exercise, depression
optical coherence tomography guided antithrombotic treatment after endovascular thrombectomy of the posterior circulation

Conditions: Stroke of Basilar Artery; Optical Coherence Tomography; Antithrombotics; Endovascular Thrombectomy

Summary: evidence regarding the role of early (\<24 hours) antithrombotics post-revascularization with either intravenous thrombolysis (ivt), endovascular thrombectomy (evt), or a combination of both remains scarce. in 2018 the american heart association/american stroke association changed their recommendation, stating that the risk of antithrombotic therapy within the first 24 hours after treatment with ivt (with or without evt) is uncertain. this was changed after data emerged that early antithrombotics may be safe and may improve outcomes in select patients undergoing evt. recently the investigators showed for the first time that significant residual basilar thrombus can exist after evt despite complete angiographic revascularization using endovascular optical coherence tomography imaging. this residual thrombus could cause ongoing function-limiting strokes with occlusion of vital basilar perforators after evt. therefore, the investigators propose a prospective,non-randomized safety study to evaluate optical coherence tomography guided antithrombotic management for patients with confirmed residual thrombus after evt for basilar occlusion.


Eligibility criteria:
inclusion criteria: - all patients deemed candidates for endovascular thrombectomy(evt) for basilar artery occlusion. as no robust guidelines exist for the role of evt in patients with acute basilar artery occlusion, the decision for evt is made by a team of stroke neurologist and neuro-interventionalist at our regional stroke center. exclusion criteria: * high-density lesion consistent with hemorrhage of any degree. * significant established infarct size. * contraindication to receiving post-revascularization antithrombotics for any reason (history of major hemorrhage in the past six months, hereditary or acquired bleeding diathesis, major surgery within last three months, platelets \<100 x 109 /l, coagulation factor deficiency, already on anticoagulant that would not allow administration of ufh) * informed consent is not or cannot be obtained. * females of childbearing potential who are known to be pregnant and/or lactating or who have positive pregnancy tests on admission. * other serious, advanced, or terminal illness. * patients who require hemodialysis or peritoneal dialysis. * uncontrolled hypertension defined as systolic blood pressure\>185 mm hg or diastolic blood pressure\>110mm hg that cannot be controlled except with continuous parenteral antihypertensive medication

Keywords: basilar stroke thrombus optical coherence tomography
prospective analysis of urine lam to eliminate ntm sputum screening

Conditions: Cystic Fibrosis

Summary: this is a prospective, single-center, nonrandomized observational study to investigate the utility of urine lipoarabinomannan (lam) as a test to identify individuals at very low risk for having a sputum culture positive for nontuberculous mycobacteria (ntm). the study is designed to evaluate if a urine test can eliminate the need for obtaining a sputum specimen to screen for ntm in individuals with cystic fibrosis (cf). the participants will be asked to provide 3 urine samples either in person or by mail over approximately 3 years. the 3 urine sample requests will be timed to coincide with their usual clinical care and routine sputum collection.


Eligibility criteria:
inclusion criteria: * informed consent obtained online or in person from the participant * enrolled in the cff patient registry (cffpr) * be willing and able to adhere to study procedures in the context of clinical care, and other protocol requirements * diagnosis of cf consistent with the 2017 cff guidelines ntm culture status of negative (defined by a review of clinical and culture data with at least 3 years of clinical data available to review and at least one negative culture within the year prior to enrollment and no known history of previous positive cultures for pathogenic ntm) exclusion criteria: 1. has any other condition that, in the opinion of the site investigator/designee, would preclude informed consent or assent, make study participation unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives
role of empathy in curative treatment outcomes of non-metastatic colorectal cancer.

Conditions: Non-metastatic Colorectal Cancer; Empathy; Morbidity; Morality; Quality of Life

Summary: the aim of project empacol will be to investigate, while taking into consideration the clinical factors known and well described in the literature, among the non-clinical factors, in particular, patient-healthcare personnel (hcp) relationship, a link between hcp's empathy perceived by the patient, and the results of the curative treatment of non-metastatic colorectal cancer, throughout the patient's care.

empacol will be a multicenter prospective longitudinal study. over a 2-year period, in two french areas covered by a cancer register, 8 centers will include patients with non-metastatic crc, uncomplicated at diagnosis based on the curative treatment strategy, patients will be divided into three groups: group 1 (surgery alone), group 2 (surgery and adjuvant chemotherapy), group 3 (neo-adjuvant therapy, surgery and adjuvant chemotherapy). the relationship between hcp's empathy, perceived by the patient, after 2 years of inclusion, and the quality of life (qol) at one year after the end of treatment will be investigated. qol will be investigated using the qlq c-30 questionnaire. finally, a link between phc perception and oncological outcomes will be sought.

Eligibility criteria:
inclusion criteria: patients aged 18 to 75 years, french-speaking, affiliated to a social security system, having received informed information and not having expressed an unfavorable opinion to participate; carriers of non-metastatic and uncomplicated crc (without occlusion/ perforation/bleeding), requiring elective therapeutic management. the included patients have a cognitive state capable of understanding and completing the questionnaires (autonomous completion). exclusion criteria: patients who were minors or older than 80 years, residing in a department outside calvados or manche, presenting a crc other than adenocarcinoma and all metastatic forms or requiring emergency surgery (perforation, hemorrhage, occlusion), exclusive endoscopic treatment, or a missed-crc discovered after surgery for non-oncological indications. patients with another neoplastic disease under treatment and/or evolving, patients with a history of inflammatory bowel disease (crohn's disease, ulcerative colitis) and/or hereditary disease predisposing to crc (lynch syndrome, familial polyposis) or with severe cognitive impairment preventing proper comprehension of the questionnaires. pregnant women will be excluded.

Keywords: colorectal cancer empathy outcomes
effect of molecular hydrogen administration on performance and body response on exercise in national-level fin-swimmers

Conditions: Athletic Performance; Muscle Fatigue; Oxidative Stress

Summary: the aim of this randomized, double-blind, placebo-controlled crossover trial is to evaluate the effect of hydrogen-rich water consumption on performance, recovery, psychological and biochemical outcomes in elite czech fin-swimmers.

twelve czech national and international-level fin-swimmers participate in this trial. participants take molecular hydrogen via drinking hydrogen-rich water (hrw) or placebo three days before (1260 ml/day) and during testing day (2520 ml). all participants participate in two testing session and receive hrw and placebo in random order. each session includes two training units in a 25-m indoor swimming pool and a 24-hour monitored recovery. the first training unit takes place in the morning between 9 and 11 am and includes three high intensity interval sets. the afternoon training unit includes a continuous 400-m competitive performance. the washout period between testing sessions is 7 days. the variables assessed are as follows: swimming times, heart rate variability, lower limb explosive strength, rating of perceived exertion, subjective perceived muscle soreness, creatine kinase, blood lactate, and protein carbonyls. statistical analysis is based on analysis of variance for repeated measures with factors: water (hrw and placebo), time, and interaction. fisher's post-hoc tests is used for pairwise comparisons. the significance level is set at 0.05.

Eligibility criteria:
inclusion criteria: * junior or adult czech fin-swimming representative. * medical eligibility for competitive sport. * good health condition. * signed informed consent. exclusion criteria: * acute health problems. * not following instructions (free of any supplements three weeks before experiment, free of any medicaments, no caffeine at least 24 hours before experiment). * menstruation in testing session.
preliminary safety of the true vascular graft for hemodialysis access (true hd i study)

Conditions: End Stage Renal Disease

Summary: prospective, nonrandomized, single-arm, single-center, open-label, first-in-human clinical study in subjects with end-stage renal disease (esrd) and not candidates for an autogenous fistula creation.

prospective, nonrandomized, single-arm, single-center, open-label, first-in-human clinical study in subjects with end-stage renal disease (esrd) and not candidates for an autogenous fistula creation. subjects will be followed regularly with office visits at the investigational site at days 15, 29, 57 and weeks 12, 26 for vessel imaging, blood draws and other follow-up tests.

Eligibility criteria:
inclusion criteria: * patients with end stage renal disease (esrd) who are not, or who are no longer, candidates for creation of a simple autogenous av fistula (radio-cephalic or brachio-cephalic without requiring transposition) and therefore need placement of an av graft in the upper extremity to start or maintain hemodialysis therapy. * either on hemodialysis or expected to start hemodialysis within 12 weeks of study conduit implantation. * patients between 18 and 75 years old, inclusive. * life expectancy of at least 1 year. * negative covid-19 test within 3 days prior to surgery and negative for symptoms within 14 days prior to surgery. * able to communicate meaningfully with investigative staff and able to comply with entire study procedures. * willing and competent to give written informed consent. exclusion criteria: * history or evidence of severe cardiac disease (nyha functional class iii or iv), myocardial infarction within six months prior to study entry (day 1), ventricular tachyarrhythmias requiring continuing treatment, or unstable angina. * uncontrolled or poorly controlled diabetes; hospitalization for poor glucose control within the previous 6 months. * history or evidence of severe peripheral vascular disease in the upper limbs * known or suspected central vein obstruction on the side of planned graft implantation. * documented hypercoagulable state or history of thromboembolic events or history of repeated venous catheter clotting. * known positive covid 19 test result or known exposure to covid 19 in past 4 months. * known active infection including dental infection, osteomyelitis and other conditions which could present a local or systemic risk of infection. * bleeding diathesis. * contraindication to or known serious allergy to anticoagulant, aspirin, or planned antiplatelet therapy. history of heparin-induced thrombocytopenia. * contraindication to or known serious allergy to penicillin. * ongoing therapy with vitamin k antagonists or direct thrombin inhibitors or factor xa inhibitors. * immunodeficiency including aids / hiv or active autoimmune disease, or on immunosuppressant therapy. * previous ptfe graft in the operative limb unless the true graft can be placed more proximally than the previous failed graft. * more than 1 failed ptfe graft in the operative limb.
diagnostics in diverticulitis (didit)

Conditions: Diverticulitis

Summary: this study focuses on if low dose ct without intravenous contrast has a high enough specificity and sensitivity for acute diverticulitis that it can be used as the primary diagnostic method instead of a full dose ct with intravenous contrast which is the standard method in sweden.

patients will be recruited from the emergency departments in mora and vastmanland hospitals. all patients over the age of 50 with clinically suspected acute diverticulitis that meet inclusions criterium will be asked for participation. a clinical examination and blood samples will be drawn. subjects will be sent to the radiology department where they will undergo computed tomography (ct) of the abdomen. the ct protocol consists of a low dose non contrast enhanced ct followed by a normal dose ct with intravenous contrast. this is needed as randomization of patients is not possible due to the fact that the clinical diagnosis of diverticulitis is difficult and unreliable. this would lead to the situation that we would not know if a participant in the low dose ct group has diverticulitis which was not seen with the low dose protocol or if the patient did not have diverticulitis. the radiologist on call will examine the full dose ct examination and write a report as routine. at a later date three blinded radiologists will examine first all low dose ct examinations and grade them according to our ct protocol. at a later date the radiologists will evaluate all full dose ct examinations using the same ct protocol. findings will then be compared between the two different ct methods and sensitivity and specificity for low dose ct will be calculated.

Eligibility criteria:
inclusion criteria: * over the age of 50 * clinically suspected acute diverticulitis * low abdominal pain * wbc over 10 x 109/l or raised c-reactive protein levels 25 mg/l exclusion criteria: * pregnancy * previous allergy to intravenous contrast * renal failure or other reasons that the patient cannot undergo ct with iv contrast * unable to give informed consent * dementia * language barrier