Kornimate/medical-research-clean huggingface dataset:
effect of cytosorb adsorber on hemodynamic and immunological parameters in critical ill patients with covid-19

Conditions: COVID-19

Summary: this prospective randomized single center study investigates to what extent the physical elimination of the inflammatory mediators using the cytosorb adsorber reduces the morbidity of severely and critically ill patients with covid-19.


Eligibility criteria:
inclusion criteria: * confirmed covid-19 disease * refractory shock with need for norepinephrine ≥ 0.2 μg/kg/min for map ≥ 65 mmhg * il6 ≥ 500 ng/l * indication for crrt or ecmo exclusion criteria: * liver cirrhosis child pugh c * "do not resuscitate"-order * expected survival due to comorbidities \< 14 days * pregnancy or breastfeeding * participation in another interventional trial

Keywords: critically ill intensive care medicine cytosorb hemoadsorption
tele-patient-reported outcomes (telepro) in clinical practice

Conditions: Epilepsy

Summary: the aim of this study is to compare quality of care and patient experiences in two outpatients follow-up activities: 1) standard telepro (fixed interval telepro follow-up) and 2) open access telepro (patient-initiated telepro follow-up)

the traditional system of routine outpatient follow-up of chronic disease in secondary care may involve a waste of resources if patients are well. the use of patient-reported outcomes (pro) could support more flexible, cost-saving follow-up activities. ambuflex is a pro system used in outpatient follow-up in the central denmark region. pro questionnaires are sent to patients at fixed intervals. the clinicians use the pro data to decide whether a patient needs a visit or not (standard telepro). pro may make patients become more involved in their own care pathway, which may improve their self-management. better self-management may also be achieved by letting patients initiate contact. the aim of this study is to obtain data on the effects of patient-initiated follow-up (open access telepro) on resource utilisation, quality of care, and the patient perspective.

Eligibility criteria:
inclusion criteria: * males and females from age 15 years * diagnosis of epilepsy * referred to standard telepro by a clinician * access to internet (web-responders in standard telepro) * can speak and understand danish exclusion criteria: * paper responders * referred to telepro proxy questionnaire
tissue k+ in primary hyperaldosteronism

Conditions: Primary Hyperaldosteronism; Electrolyte Disturbance

Summary: recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23na-mri. tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism. besides, former animal studies applying chemical electrolyte analysis indicate that this aldosterone induced sodium storage might be accompanied by intracellular potassium loss. wether such an intracellular tissue potassium loss occurs in vivo in patients with hyperaldosteronism and if this deficiency can be corrected by treatment is unclear. the investigators will employ 39k-mr imaging at 7tesla to further assess this hypothesis.

patients diagnosed with primary hyperaldosteronism will be investigated using 23na-mri and 39k-mri at 7 tesla to assess tissue sodium and potassium content. measurements will be conducted before treatment of hyperaldosteronism and three months after adrenal surgery or medical treatment (spironolactone or eplerenone). furthermore, blood pressure, body water distribution (by bioimpedance spectroscopy), serum electrolytes as well as monocyte function will be assessed.

Eligibility criteria:
inclusion criteria: - primary hyperaldosteronism diagnosed according to the endocrinological guidelines (j clin endocrinology \& metabolism, may 2016) exclusion criteria: * chronic kidney disease stage 3b and below (estimated gfr \<30 ml/min according to ckd-epi) * acute kidney injury * severe congestive heart failure (nyha iii and iv) * liver cirrhosis (child b and c) * pregnancy * contraindications for mri measurements: cardiac pacemaker, claustrophobia, etc.

Keywords: hyperaldosteronism potassium magnetic resonance imaging
the effect of healing touch on sleep patterns of pediatric burn patients

Conditions: Burn

Summary: adequate sleep is an important aspect of any healing process, and because it is known that children recovering from burns suffer long term sleep disruptions, the investigators believe that healing touch may improve the quality and quantity of sleep in the pediatric burn population.

this study examines the impact of healing touch on the quality and quantity of sleep in pediatric burn survivors. polysomnography recordings are obtained in order to assess nocturnal sleep in conjunction with healing touch; which is done on 1 of 2 nights during polysomnography. soft background music is played on both nights. healing touch is performed by one of 2 healing touch certified practitioners.

Eligibility criteria:
inclusion criteria: 1. all pediatric patients (from 5 to 21 years of age) admitted for treatment (following an acute burn injury) to shriners hospitals for children - cincinnati burns hospital will be screened. 2. include electrical, flame, scald and chemical burns. 3. signed informed consent exclusion criteria: 1. patients admitted for treatment unrelated to a burn injury. 2. patients admitted for less than 2 nights. 3. patients with face and head grafting if they interfere with the lead placements 4. neurological disorder

Keywords: polysomnography sleep healing touch pediatric burn
cluster randomized trial of hospitals to assess impact of targeted versus universal strategies to reduce methicillin-resistant staphylococcus aureus (mrsa) in intensive care units (icus)

Conditions: Methicillin-resistant Staphylococcus Aureus

Summary: the randomized evaluation of decolonization versus universal clearance to eliminate mrsa (reduce mrsa) trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant staphylococcus aureus (mrsa) in intensive care units. the three strategies to be evaluated are: * screening on admission followed by isolation of mrsa+ patients * screening on admission followed by isolation and decolonization of mrsa+ patients * universal decolonization on admission with no screening. the decolonization regimen involves bathing with chlorhexidine plus intra-nasal application of mupirocin. the main outcome will be mrsa+ clinical cultures. the study is a partnership between the cdc, the cdc prevention epicenters, and the hospital corporation of america.

baseline data involving 12 months of data for participating hospitals (july 2008 - june 2009) was collected prior to randomization to account for size and icu baseline prevalence of mrsa in randomization scheme. randomization occurred at the hospital level. eligibility survey was conducted to determine exclusion criteria. as of may 2010, enrollment has been closed. 45 hospitals were randomized, but two were found to meet exclusion criteria and were excluded. as-randomized (or as-assigned) analysis included 43 hospitals, representing 74 icus. individual (patient-level) subject enrollment during intervention is 74,256.

Eligibility criteria:
inclusion criteria: * inclusion criteria will include all hca hospitals that reside in us states where physicians do not routinely prescribe decolonization for mrsa + icu patients. exclusion criteria: * exclusion criteria will include hospitals where icu physicians often prescribe decolonization for mrsa+ icu patients. * dedicated burn icus will also be excluded due to the inability to perform routine bathing. * finally, since the intent is to assess the intervention in adult icus, pediatric hospitals will be excluded although patients \<13 years old that are admitted to participating adult icus will be included in the unit-based intervention.

Keywords: mrsa infection
peak: panitumumab plus mfolfox6 vs. bevacizumab plus mfolfox6 for first line treatment of metastatic colorectal cancer (mcrc) patients with wild-type kirsten rat sarcoma-2 virus (kras) tumors

Conditions: Colon Cancer; Colorectal Cancer; Rectal Cancer; Metastatic Colorectal Cancer

Summary: the primary objective of this study is to estimate the treatment effect on progression-free survival (pfs) of panitumumab relative to bevacizumab in combination with mfolfox6 chemotherapy as first-line therapy in patients with tumors expressing wild-type kras, unresectable mcrc.


Eligibility criteria:
inclusion criteria: * histologically or cytologically-confirmed adenocarcinoma of the colon or rectum in patients with unresectable metastatic (m1) disease * patients with at least 1 uni-dimensionally measurable lesion of at least 10 mm per modified response evaluation criteria in solid tumors (recist) guidelines * wild-type kras tumor status confirmed by an amgen approved central laboratory or an experienced laboratory (local laboratory) per local regulatory guidelines using a validated test method * eastern cooperative oncology group (ecog) score of 0 or 1 * men or women 18 years of age or older * adequate hematologic, renal, hepatic, metabolic, and coagulation function exclusion criteria: * history of prior or concurrent central nervous system (cns) metastases * prior chemotherapy or other systemic anticancer therapy for treatment of metastatic colorectal carcinoma * clinically significant cardiac disease * clinically significant peripheral sensory neuropathy * active inflammatory bowel disease * recent gastroduodenal ulcer to be active or uncontrolled * history of interstitial lung disease * recent pulmonary embolism, deep vein thrombosis, or other significant venous event * pre-existing bleeding diathesis and/or coagulopathy with exception of well-controlled anticoagulation therapy * recent major surgical procedure, open biopsy, or significant traumatic injury not yet recovered from prior major surgery.

Keywords: colon cancer colorectal cancer rectal cancer panitumumab vectibix modified folfox 6 mfolfox 6 folfox bevacizumab avastin first-line metastatic
detecting delayed discharge in acute geriatric unit using natural language processing

Conditions: Language; Geriatric; Older; Electronic Health Record

Summary: delayed discharge in geriatric units is a health and economic issue. there is no algorithm to automatically measure the appropriateness of admissions or hospital days. 30% of the days of hospitalization in acute geriatric units (agu) are not appropriate. waiting for a transfer to a follow-up care and rehabilitation unit (ssr) is the main risk factor for inappropriate days. the purpose of this project is to develop an algorithm using natural language processing to predict the appropriateness of an admission to uga, or a day at uga.


Eligibility criteria:
inclusion criteria: * age : \>75 years * patient hospitalized in an agu exclusion criteria: * refusal to participate

Keywords: natural language process appropriate stay acute geriatric unit older electronic health record.
bevacizumab and nimustine in patients with recurrent high grade glioma

Conditions: Glioblastoma

Summary: the purpose of this study is to determine whether bevacizumab and nimustine are effective in the treatment of recurrent high grade glioma and to explore whether there is any subgroup being sensitive to this therapeutic protocol.

although anti-angiogenesis therapy for glioblastoma(gbm) are showing promise, gbms often develop resistance to treatment within months or weeks after salvage therapy. there are still no effective markers to predict the response rate to bevacizumab. so the investigators initiate a single-arm phase ii study to evaluate the efficacy and tolerability of bevacizumab and nimustine regimen and to explore the predictive markers in patients with recurrent high-grade glioma.

Eligibility criteria:
inclusion criteria: * histological diagnosis of primary tumor as high-grade gliomas (who iii or iv) * all patients should complete radiotherapy and chemotherapy for primary gliomas * enhanced mri and magnetic resonance spectroscopy showed unequivocal evidence of tumor recurrence or progression. * those patients underwent surgical resection after tumor recurrence can also be enrolled if histological diagnosis of gbm is available, and mri within 3 days after operation is needed. * the patients with recurrent gliomas didn't undergo bevacizumab therapy before enrollment. * the time to be enrolled should be more than 90 days after the radiation therapy, more than 28 days after operation for recurrent tumor or prior chemotherapy. * eastern cooperative oncology group score: 0-2 * written informed consent * laboratory test: neutrophil count \> 1.5\*10\^9/l, platelet count \> 100\*109/l, hemoglobin \> 8 g/dl, blood urea nitrogen and creatinine \< 1.5 upper limit of normal(uln), blood total bilirubin and conjugated bilirubin \< 1.5 uln, alanine aminotransferase(alt) and aspartate aminotransferase(ast) \< 3 uln, alkaline phosphatase(akp) \< 2 uln exclusion criteria: * pregnant or lactating women * allergic to administered drugs * radiation therapy in the previous 90 days before enrollment * the patients with recurrent gliomas were treated with bevacizumab therapy before enrollment. * acute infection in need of antibiotics intravenously * participation in other clinical trials in the 90 days before enrollment

Keywords: bevacizumab nimustine pathology, molecular
efficacy of drug and risk behavior counseling intervention among injecting drug users at opioid substitution treatment

Conditions: Substance Use Disorders

Summary: behavior drug and risk reduction counseling (bdrc), a structured, non-intense, cognitive-behavioral approach intervention designed to increase methadone maintenance treatment retention and reduce drug use and related risk behaviors among idus.

techniques of the cognitive behavior therapy combined with drug dependence psychoeducation was developed by research team. bdrc consists of 12 sessions, including an initial session, 3 drug education sesssions, psychosocial counseling and behavioral skills. this initial session is designed to introduce the counselor, review the purpose and expectations of counseling, review the rules of confidentiality, agree on attendance times and rescheduling rules, and to begin to collect information from the participant on their drug use and risk behaviors. behavioral contracting is a key component to this counseling approach. drug education focuses on how heroin may influence patients' cognitive function and their hiv/hcv risk behaviors. counseling and behavior skills trained patients to reflect their thoughts and learned new life skills in order to delay or abstrain from heroin use.

Eligibility criteria:
inclusion criteria: * enrollment in opioid substitution treatment * injected heroin within past 30 days by self-report, documented by "tracks" or puncture marks * 20 or more years of age * meets icd-10 criteria for opiates dependence with physiologic features * agrees to keep bi-weekly appointments if selected * current address within taipei and keelung, and not planning to move * willingness and ability to give informed consent and otherwise participate * provision of adequate locator information exclusion criteria: * clinically significant cognitive impairment, schizophrenia, paranoid disorder, bipolar disorder * advanced neurological, cardiovascular, renal, or other medical disorder that is likely to impair or make hazardous patient's ability to participate * physiologically dependent on alcohol, benzodiazepines or other sedative type drugs * concurrent participation in another treatment study * planning to enter inpatient or residential treatment within next year * pending legal charges with likely incarceration within next 12 months

Keywords: behavior drug and risk reduction counseling heroin addiction treatment randomization treatment effect
effectiveness of online exercise training in geriatric population during covid-19

Conditions: Aging; Falling; Dependence; Inactivity, Physical

Summary: the aim of this study is to investigate the effectiveness of online exercise training in geriatric population whose daily life activity level decreased during covid-19 pandemic. the main questions it aims to answer are: * does online exercise training improve quality of life in the geriatric population whose daily life activity levels have decreased during the covid-19 pandemic? * does online exercise training improve sleep quality in the geriatric population whose daily life activity levels have decreased during the covid-19 pandemic? * does online exercise training affect depression status in the geriatric population whose daily life activity levels have decreased during the covid-19 pandemic? * does online exercise training reduce the risk of falls by improving balance and functional independence in geriatric population whose daily life activity levels have decreased during the covid-19 pandemic? * does online exercise training improve posture in geriatric population whose daily life activity levels have decreased during the covid-19 pandemic? research data were collected by sociodemographic information form, 36-item short form survey, the pittsburgh sleep quality index, geriatric depression scale, timed up \& go test, and new york posture rating chart. while no application was given to the control group, study group has received an online exercise training with a structured exercise program including range of motion, stretching, and, to train full body, low intensity aerobic exercises, once a week for 10 weeks, each lasting 60 minutes.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * being over 65 years old exclusion criteria: * having mental retardation at a level that prevents communication * having an uncontrollable heart and hypertension problem * being receiving medical treatment or rehabilitation for balance that may affect the balance level * having osteoporosis at a level where exercise can be considered risky * having a health problem where exercise is considered contraindicated

Keywords: covid-19 activities of daily living geriatrics telerehabilitation
prevalence of self-medication for dental conditions by parents for their children

Conditions: Self-medication for Dental Conditions

Summary: to evaluate prevalence of self-medication for dental conditions by parents for their children. self-medications practices.

according to the world health organization, self-medication is the act of medicating oneself, either on their own initiative or on the advice of a close person, to treat self-recognized conditions or symptoms without supervision by a healthcare professional. the growth and dissemination of self-medication practice represents a serious global public health issue, with increased risks of adverse drug reactions, non-beneficial drug interactions, drug abuse, and the emergence of drug-resistant pathogens. parents are the primary caregivers to whom children report their symptoms. but due to the presence of economic and time constraints, some parents seek the practice of self-medication for their children . however, children have a growing body reacting differently to the drugs (need of dose adjustment, choice of the proper route of administration and the need of taking in consideration the pharmacokinetics and pharmacodynamics particularities of medicines) and therefore the inappropriate and unguided use of medications may lead to fatal complications.

Eligibility criteria:
inclusion criteria: * parents of healthy children up to 10 years. * parents who accept to participate in the study exclusion criteria: * guardians other than parents (child's father or mother).

Keywords: self-medication-drug interactions
early increase in blood supply in patients with barrett's esophagus

Conditions: Barrett's Esophagus

Summary: the purpose of this study is to determine if early barrett's specialized intestinal metaplasia can be detected by measuring early increased blood supply of the esophageal tissue, with 4 dimensional elastic light-scattering fingerprinting, (4d-elf) technology in real time.


Eligibility criteria:
inclusion criteria: * age 18 years or older, * informed written consent, * patient scheduled for previously planned upper endoscopy exclusion criteria: * liver disease; * gastric antral vascular ectasia (gave);any known non-esophageal aerodigestive malignancy; * severe cardiopulmonary disease precluding endoscopy; presence of conditions not allowing biopsy (e.g. coagulation disorder); * known familial polyposis syndrome (fap, hnpcc, juvenile polyposis, etc.); * known pregnancy or sexually active females of childbearing age who are not practicing an accepted form of birth control.
pci in beijing friendship hospital

Conditions: Cardiovascular Diseases; Percutaneous Coronary Intervention

Summary: the goal of this study is to discover the potential risk factors related percutaneous coronary intervention. it aims to stratify the risk of pci patients and discover the prognostic value of these risk fators.

coronary heart disease is the main cause of death worldwide. ischemic heart disease is the most common cause of death. percutaneous coronary intervention (pci) is a very effective treatment for coronary heart disease, which can alleviate myocardial ischemia and reduce the mortality of patients with acute myocardial infarction. it is an important measure to treat coronary heart disease at present. however, the study found that the incidence of major adverse cardiac and cerebrovascular event (macce) after pci was more than 10%, which could reach 20-30% in elderly patients. therefore, the purpose of this study is to investigate the risk factors related to pci and to intervene or change the treatment strategy as early as possible. risk stratification was performed in these patients for improving the quality of life of patients, reducing medical costs, and improving the life expectancy of patients. patients with pci in beijing friendship hospital are enrolled.the primary outcome is macce and all-cause mortality.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years at the time of admission to the hospital * pci patients with coronary heart disease: according to the criteria interpreted in the 2011 american guidelines for percutaneous coronary intervention. the successful diagnostic criteria of pci: residual stenosis of the treated vessel\<10% (preferably 0%), and the forward flow is timi grade 3, there is no dissection that affects the flow, no important side branch occlusion, no visible thrombus and peripheral embolism. exclusion criteria: * patients who failed in pci treatment; * current known inability to follow instructions or comply with follow-up procedures.

Keywords: coronary heart disease