Kornimate/medical-research-clean huggingface dataset:
autologous cd133(+) cells as an adjuvant to below the knee percutaneous transluminal angioplasty

Conditions: Peripheral Arterial Disease

Summary: the main aim of the present study was to evaluate the therapeutic potential and safety of transarterial infusion of granulocyte colony stimulating factor (g-csf) mobilized cluster of differentiation (cd) 133(+) cells when combined with percutaneous transluminal angioplasty (pta) in treatment of below the knee (btk) peripheral arterial disease (pad) in diabetic patients.

cd133+ cell, a bone marrow derived subpopulation of adult hematopoietic progenitor cells, confers high proliferative, vasculogenic and regenerative capacity in vitro and in vivo. thereby suggesting that cd133+ cells may induce vasculogenesis, improve limb perfusion, prevent tissue loss and restore ambulatory function in patients with critical limb ischemia. although several small, randomized trials have been conducted so far demonstrating safety of autologous cells of bone marrow origin for the treatment, the reported benefits were found to be variable. a meta-analysis of autologous bone marrow derived cell therapy for critical limb ischemia trials suggested that application of autologous stem cell transplantation in curing limb ischemic patients does not have obviously effectiveness in the improvement of ankle brachial pressure (abi) of the limb ischemic patients. but it can dramatically reduce the rate of amputation. therefore, in the present study, the investigators aim to evaluate the therapeutic potential and safety of transarterial infusion of g-csf-mobilized cd 133(+) cells when combined with pta in treatment of below the knee pad in diabetic patients.

Eligibility criteria:
inclusion criteria: 1. age range: 18-75 years , gender: both 2. patients with below the knee limb ischemia with diabetes. 3. rutherford class 2-6. 4. target lesions with a diameter reduction of at least 50% and have an occlusion of longer than 4 cm on angiography. 5. have no previous history of any stem cell therapy \[infusion of cd133 endothelial progenitor cell (epc)\]. written informed consent signed by the patients or representatives. - exclusion criteria: 1. previous bypass surgery or stent placement at the ipsilateral lower limb 2. history of intolerance to antiplatelet therapy, heparin, or contrast media. 3. presence of any of the following conditions: 1. severe liver disease (such as ascites, esophageal varices, liver transplantation); 2. hemodynamic instability; 3. severely impaired renal function (serum creatinine level \> 2.5 mg/dl). 4. receiving immunosuppressive therapy; 5. history of decompensated heart failure (new york heart association class iii or iv and level) or myocardial infarction, or heart bypass surgery; 6. bleeding diathesis; 7. active systemic bacterial infection; 8. acute thrombophlebitis or deep vein thrombosis of the target limb; 4) pregnant or lactating women, or women of child bearing age unable or unwilling to use effective contraception during the study period; 5) expected survival time of less than 24 months -

Keywords: endothelial progenitor cell percutaneous transluminal angioplasty
telerehabilitation-based exercises vs standard home-based exercise in low back pain

Conditions: Low Back Pain

Summary: the objective of the study is to compare the effect of a telerehabilitation-based exercise program, versus a home therapeutic exercise program scheduled through a dossier and an exercise diary, with respect to disability (measured using the oswestry questionnaire) and other variables (range of motion, strength, fatigue, histological changes, pain, medication intake, psychosocial factors and adherence), in patients with low back pain.

the objective of the study is to compare the effect of a telerehabilitation-based exercise program, versus a home therapeutic exercise program scheduled through a dossier and an exercise diary, with respect to disability (measured using the oswestry questionnaire) and other variables (range of motion, strength, fatigue, histological changes, pain, medication intake, psychosocial factors and adherence), in patients with low back pain. this randomized controlled trial has a parallel design, with two groups. both groups will complete an 8-week home exercise program that includes flexibility and strength exercises. the program will be carried out with a frequency of 3 weekly sessions, preferably on alternate days. in the case of the experimental group, the program will be carried out with the support of the trak computer tool (https://www.trakphysio.com/es/), which allows the exercises to be carried out in front of a camera that, with the help of an artificial intelligence system, offers feedback to the participant and allows investigators/clinicians to keep a record of the sessions. in the case of the control group, the program will be carried out with the support of an information dossier of the exercises to be performed and a monitoring diary in which everything related to the sessions carried out will be noted. in both groups, as an addition to the home sessions, two face-to-face sessions will be held in the first and fifth weeks, respectively. the exercise program includes flexibility and strength exercises, each made up of three levels of difficulty (easy, intermediate and difficult), with patients advancing to subsequent levels once each level is successfully overcome.

Eligibility criteria:
inclusion criteria: * nonspecific subacute or chronic low back pain exclusion criteria: * neuropathic pain * pain below the knees * pain in legs with tingling, sensation of current or sensory alterations * positive neurological tests. lack of strength, sensitivity or altered reflexes * canal stenosis * nociplastic pain (fibromyalgia, generalized pain, emotional lability, affective and cognitive implications) * previous lumbar surgery * specific pathology (rheumatic, spondylolisthesis, oncological, fractures...) * pregnancy * performing medium-high intensity exercise of more than 100 minutes a week * pathology that prevents exercise (decompensated cardiac pathology, decompensated respiratory pathology, significant mobility difficulties...) * lack of digital skills * visual problems that prevent exercise with the phone screen

Keywords: low back pain exercise telerehabilitation
retrospective study of keloid disorder

Conditions: Keloid

Summary: purpose of this retrospective study is to review and analyze the information and data that has been already been generated during the course of routine practice of medicine by the investigators from 2007 up until sept 1, 2016 from keloid patients who have sought medical care or medical advice for their keloid disorder.

to retrospectively review and analyze clinical data that has already been collected from keloid patients including photographs taken of keloid lesions during routine practice of medicine by the investigators 1) to better understand natural history of keloid disorder (kd), 2)to determine the ethnic incidence and prevalence of keloid, 3) to determine the rate of familial keloids, 4) to determine response to different treatment modalities, 5) to determine risk factors for development and worsening of keloid lesions.

Eligibility criteria:
inclusion criteria: * all patients must have at least one keloid lesion. * availability of photographic documentation of keloid lesion(s). exclusion criteria: * lack of photographic documentation of keloid lesion(s) * lack of demographic data

Keywords: keloid
risk of falls in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia is a chronic illness characterized by persistent widespread muscle pain with generalised hyperalgesia and allodynia. it can be accompanied by other concomitant symptoms: fatigue, sleep disturbances, musculoskeletal disorders, distress and psychological disorders. the prevalence has been reported to be between 2 and 5%. the hypothesis of this study is that women with fibromyalgia present high risk of falls and balance disorders compared with healthy women. the objective of this study was to investigate wether gait pattern changes in single and dual task conditions were associated with the risk of falling in women with fibromyalgia.

falls and fall-related injuries are a common health problem. a fall is often a result of intrinsic physiological ageing and underlying chronic disease interacting with the external and challenging environment. disturbances in physical function, muscle strength, range of motion, poor balance, affectation in sensory system, a loss of proprioception, alteration concerning visual and vestibular aspects, dizziness, decreased endurance and cognitive and mobility impairment are the most common risk factors for falls. postural control in a dual task setting is especially relevant to daily life situations. attending to that, we propose an assessment based on these parameters in women with fibromyalgia.

Eligibility criteria:
inclusion criteria: * women diagnosed with fibromyalgia attending to the fibromyalgia association of granada. * women who can complete the assessment battery of tests and tasks. exclusion criteria: * auditive and visual disturbances. * cognitive problems. * psychiatric pathology. * gait serious disturbances. * concomitant neurological conditions

Keywords: fibromyalgia balance falls
the bioavailability and effect on pouch ph of esomeprazole after gastric bypass

Conditions: Obesity; Gastric Reflux; Ulcer, Gastric

Summary: the objective of this study is to investigate the effect of esomeprazol administered in tablets (esomeprazol mut sandoz® 40mg) or in solution (esomeprazol mut sandoz® 40mg in 10ml tap water) on acid production in the gastric pouch by measuring the intragastric ph and the serum concentration of esomeprazole.

to assess the clinical effect of the esomeprazole absorption after roux-en-y gastric bypass, we intend to measure the serum concentration after administration as intact capsules or open in solution and correlate it with the ph in the gastric pouch, measured with the wireless bravotm capsule ph measurement system. the feasibility and safety of the wireless ph monitoring system has been shown before. the patients who met all the inclusion criteria undergo a routine upper endoscopy one year after rygb. at the end of the endoscopy, the wireless bravo™ - ph monitoring device is placed and the participant is discharged with ongoing ph monitoring. the next day, the participant is randomized to either receive esomeprazol mut sandoz® tablet 40mg or esomeprazol mut sandoz® 40mg in solution. serum concentration of esomeprazol is measured at 0, 60 and 120 minutes and the patient is discharged after. after 48 hours of ph monitoring, the patient returns the bravo™ - recorder, adverse events are assessed and the study is terminated.

Eligibility criteria:
inclusion criteria: * proximal roux-en-y gastric bypass with linear stapled anastomosis 12 months prior to the study investigation * routine administration of proton pump inhibitors for 6 months postoperatively * no intake of proton pump inhibitors at least 4 weeks prior to study investigation * no marginal ulcers in upper endoscopy prior to placement of wireless bravo™ ph monitoring capsule * no symptoms related to gastro-esophageal reflux or marginal ulcers (i.e. epigastric pain, retrosternal burning, regurgitation) * informed consent as documented by signature exclusion criteria: * known intolerance or allergy for esomeprazol * contraindication for upper endoscopy * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * women who are pregnant or breast feeding major hepatic dysfunction
effect of passive smoking on oxidative stress and dental caries in children

Conditions: Oxidative Stress; Dental Caries; Passive Smoking

Summary: the purpose of the present study was to determine the effect of passive smoking on oxidative stress and dental caries in children.a total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). dental examination of children were performed and caries prevalence of the patients were recorded. unstimulated saliva samples were collected from children. saliva 'cotinine levels' and oxidative stress markers 'total antioxidant status' (tas), and' total oxidant status' (tos) were evaluated by using enzyme-linked immunosorbent assay (elisa). the obtained data parameters of the two groups were evaluated and comparison was performed.


Eligibility criteria:
inclusion criteria: -systemically healthy children exclusion criteria: * uncooperative children * the presence of orthodontic/intraoral appliance * any disease or condition known to affect oxidative stress
total antioxidant capacity before and after hrt in hypotalamic amenorrhea

Conditions: Hypothalamic Amenorrhea

Summary: the aim of our study is to investigate the effects of 6 months oh hrt on total anti-oxidant capacity, clinical, endocrine and metabolic features in women affected by hypotalamic amenorrhea. the study group included 20 patients treated with 1 mg of transdermal estradiol daily and 10mg of oral medroxyprogesterone acetate from 16th to 24th day of therapy for six months. menstrual pattern, anthropometric parameters, hormonal assays, dxa and bone metabolism parameters are evaluated before and after therapy.


Eligibility criteria:
inclusion criteria: * hypotalamic amenorrhea exclusion criteria: * diabetes mellitus (or impaired glucose tolerance as determined by a standard 75 gr oral glucose tolerance test) * hypertension * significant liver or renal impairment * other hormonal dysfunction (hypothalamic, pituitary, pcos, thiroidal or adrenal) * neoplasms
safety and efficacy study of different formulations of bimatoprost once-daily in patients with glaucoma or ocular hypertension

Conditions: Glaucoma; Ocular Hypertension

Summary: this study evaluates the safety and efficacy of different formulations of bimatoprost ophthalmic solution compared with bimatoprost 0.03% once-daily in patients with glaucoma or ocular hypertension. one of the test formulations was given to one eye and bimatoprost 0.03% given to the fellow eye of each patient


Eligibility criteria:
inclusion criteria: * ocular hypertension or glaucoma in both eyes * require iop-lowering therapy in each eye exclusion criteria: * uncontrolled systemic disease * known allergy or hypersensitivity to bimatoprost
mutations of glucocorticoid receptor in bilateral adrenal hyperplasia

Conditions: General Glucocorticoid Resistance

Summary: as the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. to validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of cushing's disease. in all these patients gr gene will be studied, mutations will be detected and described, functional disturbance will be tested. usual polymorphisms will be described. correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of gr mutations will be searched.


Eligibility criteria:
inclusion criteria: * patients more than 18 years of age * patients with bilateral adrenal masses exclusion criteria: * refusing to participate in the study * protected by law * have obvious signs of cushing's syndrome * no progressive neoplastic disease
the effects of progressive clinical pilates exercises applied as 2 different ways in fibromyalgia

Conditions: Fibromyalgia

Summary: the aim of this study is to compare the effects of progressive clinical pilates exercises applied as group under the supervision of a physiotherapist and home exercise programs on pain level, physical condition, functional status, psychosocial status and quality of life in individuals with fibromyalgia between the ages of 20-50.

after the voluntary individuals with fibromyalgia (fm) who meet the inclusion criteria are evaluated, they will be randomly divided into two groups: exercise group and home exercise group. the same clinical pilates program will be applied to both groups at the same dosage. evaluations and treatment will be applied to both groups by the same physiotherapist. individuals will perform the exercises 10 repetitions, 3 days a week, for 6 weeks. the exercise program will be progressed as basic stabilization exercises in the first 3 weeks, advanced stabilization exercises in the last 3 weeks, as recommended in the literature, and a 30-second rest will be given between sets. for the home exercise group, all exercises will be shown and it will be ensured that they are performed correctly. patients will be given an illustrated and descriptive exercise program brochure containing information about exercise position, number of repetitions, contraction duration, rest time between sets, frequency, and an exercise diary for exercise tracking.

Eligibility criteria:
inclusion criteria: * volunteer individuals between the ages of 20-50 * diagnosed with fibromyalgia according to the american college of rheumatology criteria * pain level 3 and above according to visual analogue scale. * individuals who are sedentary (who have not engaged in physical activity at least 3 days a week in the last 3 months) will be included in the study. exclusion criteria: * having additional rheumatic disease * using nsaids and antidepressant drugs * individuals with orthopedic, neurological and cardiopulmonary diseases that prevent them from exercising * pregnant women * malignancy * individuals with uncontrolled systemic diseases (diabetes, systemic arterial hypertension, thyroid dysfunction, neurological, cardiorespiratory, musculoskeletal problems, etc.)

Keywords: exercise chronic pain clinical pilates functional psychosocial
a phase i trial of zio-101 in solid tumors

Conditions: Solid Tumors

Summary: a phase i trial of zio-101 (darinaparsin) in solid tumors


Eligibility criteria:
inclusion criteria 1. subjects with histological confirmation solid malignancy refractory to conventional standard therapies for their condition 2. eligible subjects must have at least one measurable lesion as defined by recist guidelines. if the measurable disease is restricted to a solitary lesion, its neoplastic nature should be confirmed by cytology/histology. measurable lesions must not have been in a previously irradiated field or injected with biological agents 3. pediatric subjects will be eligible at the discretion of the primary investigator. 4. ecog performance status score ≤ 2 5. women of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile) must use acceptable contraceptive methods (abstinence, intrauterine device \[iud\], oral contraceptive or double barrier device), and must have a negative blood or urine pregnancy test within 1 week before beginning treatment. sexually active men must also use acceptable contraceptive methods 6. subjects must provide written informed consent prior to treatment 7. at least 4 weeks from prior completion of prior therapy to day 1 of study drug 8. baseline toxicity assessment ≤ grade 1 except treatment induced alopecia (nci common toxicity criteria version 3.0) 9. evidence of adequate multi-organ functional status as reflected by the following clinical laboratory values: * serum creatinine ≤ 2 times the upper normal limit or a calculated creatinine clearance ≥ 50 cc/min * total bilirubin ≤ 2 times the upper normal limit * alanine aminotransferase (alt), or aspartate aminotransferase (ast) ≤ 3 times the upper limit of normal 10. granulocytes in peripheral blood greater than or equal to 1 x 10(9) per liter, hemoglobin greater than or equal to 8.5 g/dl, and platelets greater than or equal to 50,000 /microl exclusion criteria 1. uncontrolled systemic infection (documented with microbiological studies) 2. active heart disease as defined by an acute myocardial infarction within the previous 6 months before starting therapy, stable or unstable angina, clinically significant arrhythmia requiring medical management, or new york heart association classification of functional activities. class 3: subject has marked limitation in activities due to symptoms, even during less-than-ordinary activity and is comfortable only at rest or class 4: severe limitations. subject experiences symptoms even while at rest 3. concomitant therapy for solid cancer 4. pregnant subjects and those who are breast-feeding 5. history of an invasive second primary malignancy diagnosed within the previous 3 years except for stage i endometrial/cervical carcinoma or prostate carcinoma treated surgically, and non-melanoma skin cancer 6. documented personal or family history of prolonged qt syndrome 7. 12 lead electrocardiogram with a corrected qt interval \> 460 milliseconds 8. history of confusion or dementia 9. history of seizure disorder
evaluation of thyroid exposure to radiation doses during paediatric cardiac catheterisations performed for diagnosis or the treatment of congenital heart disease

Conditions: Cardiac Catheterizations

Summary: the purpose of this study is to determine the average risk for thyroid irradiation for any type of paediatric cardiac catheterization, based on the cummulative at-risk dose of 100 msv, adjusted to the measured thyroid volume and to the patient's age.


Eligibility criteria:
inclusion criteria: * inclusion of any patient (\< 18 year-old) with congenital heart disease undergoing one or more cardiac catheterization exclusion criteria: * exclusion of patients with any type of thyroid dissease