Kornimate/medical-research-clean huggingface dataset:
evaluation of harmonicity in running gait by the use of innovative techniques of video analysis

Conditions: Injuries

Summary: this study aims to demonstrate the use of a digital video analysis method to evaluate harmonicity of running gait, through an holistic approach. furthermore, it explores the association of running gait harmonicity with running velocity and level of training and with running injuries risk .

aetiology of running related injuries is reported to be multifactorial but still not fully understood. factors that impede the understanding of the mechanisms and aetiology of injury are the traditional segmental approach to the analysis of running gait and the lack of prospective studies. a more holistic approach to analysis of movement could permit a more in depth comprehension of the injured state, trough a changing of point of view. this holistic approach is based on the harmonic nature of running gait. despite the everyday use of the term "harmonicity" within sporting domains, methods to measure running gait harmonicity is a theme still vaguely explored. traditional methods evaluate the movement quality of the whole body based on the motion analysis of specific segments, that are supposed to sufficiently represent the entire body. the search for a method to analyse harmonicity of cyclic movements with a real holistic approach, is therefore still open. with these aims, an innovative video analysis method has been proposed, based on the measure of the frequency variation of the pixel brightness in the digital video of a cyclic movement.

Eligibility criteria:
inclusion criteria: * at least one year of running practice * minimum two day of running/week * minimum 20 km running/week * seasonal best on half marathon comprised between 1h20' and 2h00' * experienced in treadmill running practice * sport medical certificate exclusion criteria: * have suffered in the last three months of musculoskeletal disease * regular practice of sport activities different from running * acute or chronic osteoarticular diseases or, in general, other pathology limiting physical activities * use of drugs altering physical activity performance (hypnotic, psychoactive, non-steroidal anti-inflammatory drugs e.g.).

Keywords: running harmonicity running related injuries
evaluate the pharmacokinetics of bms-986177 from two formulations in healthy participants

Conditions: Thrombosis

Summary: assess the pharmacokinetics (fasting and fed), safety, and tolerability of bms-986177 following oral dosing of form a and form b


Eligibility criteria:
inclusion criteria: * body mass index 18.0 to 32.0 kg/m2, inclusive * women must not be of childbearing potential (cannot become pregnant) exclusion criteria: * any significant acute or chronic medical illness * head injury in the last 2 years * history of bleeding disorder including rectal bleeding (ie, hemorrhoids), spontaneous nosebleeds, etc. other protocol defined inclusion / exclusion criteria could apply
subacromial injection of allogeneic platelet rich plasma (prp) for shoulder impingement syndrome

Conditions: Shoulder Impingement Syndrome

Summary: the purpose of this study is to investigate the efficacy of allogeneic prp in patients with subacromial impingement disease


Eligibility criteria:
inclusion criteria: * male or female 18 years of age and older * patients who have unilateral shoulder pain. * patients who have had pain at least for 3 months * to be included in the study- participants are required to have a \& b.(mentioned below) 1. pain with one of the two tests * neer's sign: passive overpressure at full shoulder flexion with the scapula fixed * hawkins test: passive internal rotation at 90 degree of shoulder flexion in the scapular plane and in progressive degree of horizontal adduction 2. pain with one of the two tests * painful arc: active shoulder abduction * jobe's test: the examiner passively elevates the patient's shoulder to 90 degrees of abduction with internal rotation. the examiner then applies a downward pressure against the arm exclusion criteria: * patients who received any drug by subacromial injection for treatment within 3 months prior to this enrollment. * patients who have a history of shoulder trauma including dislocation- subluxation- and fracture- breast cancer- or surgery around shoulder- neck and upper back * patients who have a isolated acromioclavicular joint pathology * patients who have a full-thickness rotator cuff tear (evidenced by mr or ultrasonography) * patients with symptomatic cervical spine disorders * patients who have a history of allergic adverse reactions to corticosteroid * patients are unable to give informed consent to participate in the study * patients are unable to come into the clinic for regular follow-up * patients with adhesive capsulitis- acromioclavicular arthropathy- polyarthritis- infectious arthritis- rheumatoid arthritis or diagnosed fibromyalgia * patients with concurrent bilateral shoulder pain * patients with neurological deficit * patients who have severely abnormal radiological findings including malignancy, severe osteoarthritis of the glenohumeral joint, severe skeletal abnormalities decreasing the subacromial space and etc. * presence of shoulder pain with limitation of both active and passive movements of the glenohumeral joint of 25% in at least 2 directions (abduction, flexion, external rotation, internal rotation), as compared with the contralateral shoulder or with normal values * patients with diabetes mellitus * patients taking anticoagulants * pregnant women or lactating mothers * patients who are difficulty participating in data collection due to communication problem and serious mental illness * patients with serious condition which can affect this study such as severe cardiovascular diseases- renal diseases- liver diseases- endocrine diseases- and cancers
comparing interleukin-2 (il-2) combined with rituximab (rituxan) to rituximab alone in subjects with non-hodgkin's lymphoma (nhl)

Conditions: Non-Hodgkin Lymphoma

Summary: the purpose of this study is to determine whether interleukin-2 given 3 times weekly for 8 weeks in combination with rituximab is effective and safe when compared to rituximab given alone in the treatment of follicular nhl subjects that have never received rituximab as a treatment and are refractory or relapsed after previous chemotherapy.


Eligibility criteria:
inclusion criteria: * cd20+ follicular b-cell non-hodgkin's lymphoma with at least 1 site of measurable disease. * previous treatment with 1 to 4 prior chemotherapy regimens * ecog performance status of greater than or equal to 2 * life expectancy of greater than 18 weeks * meet safety lab requirements and organ function tests exclusion criteria: * prior treatment with rituximab or il-2 * prior radioimmunotherapy including zevalin or bexxar * 5 or more prior chemotherapy regimens * clinically significant cardiac disease, lung dysfunction, autoimmune disease, thyroid disease, active infection, unstable psychiatric condition, or hiv infection. * history of allogenic bone marrow transplant * female subjects that are pregnant or breast feeding * immunosuppressive therapy including corticosteroids or investigational agents within 4 weeks prior to the planned start of study treatment

Keywords: non-hodgkins lymphoma interleukin-2 rituximab cd20+ follicular b-cell non-hodgkins lymphoma (grade i, ii,iii)
impact of patient education website on the quality of outpatient bowel preparation for colonoscopy

Conditions: Colon Cancer

Summary: the purpose of this study is to evaluate the effectiveness of the gi clinic's currently used web-based instructions at st. paul's hospital.

colorectal cancer (crc) is a relatively common and life threatening condition that affect one in thirteen individuals in their lifetime. colonoscopy is the most used procedure to allow gastroenterologist to identify colorectal malignancies or precancerous lesions at an earlier stage, which affords a greater chance for cure. however, low bowel cleanliness hinders polyp detection rates and therefore colonoscopy effectiveness. in the past, the majority of the studies have focused on pharmacological factors to optimize bowel preparation quality. recently, the non-pharmacological factors have been found to have significant increases in bowel preparation quality. the purpose of this study is to evaluate the effectiveness of the gi clinic's currently used web-based instructions at st. paul's hospital.

Eligibility criteria:
inclusion criteria: * patients scheduled for a colonoscopy as outpatients exclusion criteria: * unable to speak english * unwilling to participate in reading online materials
ceftriaxone and jaundice in neonates

Conditions: Jaundice and Sepsis in Neonates

Summary: ceftriaxone is an antibiotic often used for the management of sepsis. neonates commonly have jaundice during the first postnatal week. ceftriaxone will be given as standard of care for sepsis and investigators will observe the effect on jaundice.


Eligibility criteria:
inclusion criteria: * term infants with sepsis requiring iv antibiotics for more than 3 days and who has total serum bilirubin 6-12 mg/dl and resolving by day 4 of life. exclusion criteria: * infants with asphyxia (apgar score \<3 at 5 minutes), chromosomal disorder, failed hearing test at baseline, family history of hearing loss, unconjugated hyperbilirubinemia requiring phototherapy, torch infection, craniofacial malformations, listeria monocytogenes infection, and any clinical conditions which will preclude discharge to home.
the hypotensive effects of home-based isometric handgrip training in older adults with pre-hypertension and hypertension - the holdage trial

Conditions: Hypertension; Pre-Hypertension

Summary: new data suggests that isometric handgrip training (iht) might become a novel tool in the treatment of hypertension. the main purpose of this research project is to evaluate the effects of home-based iht on ambulatory blood pressure in older adults with pre-hypertension and hypertension. eighty-four older adults with pre-hypertension and hypertension will be randomly distributed to one of three groups: home-based iht, home-based aerobic exercise training (aet), or attention-control group (con). each intervention will have a total duration of 8 weeks. at baseline and after completing the intervention, patients will undergo the following evaluations: 24-hour ambulatory blood pressure, cardiorespiratory fitness, endothelial function, damage and repair, arterial stiffness, inflammatory biomarkers, autonomic function, physical activity levels, dietary intake and quality of life. a qualitative analysis will also be applied to enhance the understanding of the efficacy of this intervention from the patient's perspective.


Eligibility criteria:
inclusion criteria: - exclusion criteria: * secondary hypertension * target organ damage * coronary artery disease * heart failure * any previous cardiovascular event * peripheral artery disease * renal failure * chronic obstructive pulmonary disease * insulin dependent diabetes * change of antihypertensive medication in the past 4 weeks before inclusion in the study * smokers * those participating in regular physical activity

Keywords: isometric handgrip training elderly pre-hypertension hypertension
ruminant trans fats and the risk of cardiovascular disease in women

Conditions: Cardiovascular Disease

Summary: while the deleterious effects of trans fat from industrial sources (itfa) on cardiovascular health are well established, the impact of tfa from ruminants (rtfa) on cardiovascular risk factors has not been as well characterized. we have previously shown in men that a very high dietary intakes of rtfa (\>3.5% of energy) leads to unfavourable changes in lipid cardiovascular risk factors that are similar to those seen with itfa. however, our data also indicated that achievable intakes of rtfa that remain well above the current human consumption (1.5% of energy intake) had neutral effects on plasma lipids and other cardiovascular disease (cvd) risk factors in men. other studies have also suggested that the ldl and hdl response to very high dietary intakes of rtfa (\>5% of energy) in women may be different than in men. the general objective of the study is to investigate for the first time in a double-blind randomized controlled study the impact of high but yet achievable intake of ruminant trans fatty acids on plasma ldl-cholesterol and other risk factors for cvd in healthy women.

ruminant trans fatty acids (rtfa) will come from an experimental butter formulated from dairy fat obtained after having modified the regimen of lactating cows. all diets will be identical in terms of menus, calories and macronutrient composition with the exception of tfa levels. all foods will be provided to study participants. based on a 2500 kcal/day regimen, an intake of 4.1g of rtfa will represent 37 kcal/day (1.5% of energy intake) while the intake of 0.7 g of rtfa in the control diet will represent 6 calories (0.3% of energy). the 2 experimental diets will be formulated so that the percentage of daily calories from fat (33%), carbohydrates (52%) and proteins (15%) will meet the dietary recommendations of the american heart association and the ncep for primary prevention of cvd.

Eligibility criteria:
inclusion criteria: * healthy women using or not contraceptive agents or hormone supplementation * for pre-menopausal women: regular menstrual cycle for the last 3 months (25- 35 days) * ldl-cholesterol concentration between 2.5 and 4.0 mmol/l * stable body weight (+/- 2 kg) for 6 months before the beginning of the study * smoking or not exclusion criteria: * previous history of cardiovascular disease, type 2 diabetes and monogenic dyslipidemia * subjects taking medications for hyperlipidemia or hypertension * endocrine disorders * body mass index \> 35 kg/m2 * food allergies * women with extreme nutritional habits such as vegetarism or alcohol consumption \> 2 drinks/day * elite athletes

Keywords: cardiovascular disease trans fatty acids ruminant blood lipids lipoproteins women
impact of a decision aid on patient decision making in emergency department chest pain patients

Conditions: Acute Coronary Syndrome

Summary: we are doing a study to assess the impact of including patients in making decision regarding their own medical care in the emergency department. we will randomly assign them to either receive a decision aid or usual care. in doing this, we aim to increase patient satisfaction and safely decrease medical cost.


Eligibility criteria:
inclusion criteria: * adults with a primary complaint of chest pain. * treating clinician's next consideration is observation unit admission for cardiac stress testing. exclusion criteria: * initial cardiac troponin t value \>99th percentile (\>0.01ng/ml) * history of coronary artery disease * coronary revascularization procedure within the previous 30 days * cocaine use within 72 hours by the clinician's initial history * pregnancy * patient cannot read english or have, in their clinician's judgment, major learning barriers, such as visual or hearing impairment or dementia that would compromise their ability to give written informed consent (or use the decision aid)
defining inflammation related to peritoneal carcinomatosis in women with ovarian or colon cancer.

Conditions: Peritoneal Carcinomatosis; Ovarian Cancer; Colon Cancer

Summary: inflammation plays an important role in the pathogenesis of peritoneal carcinosis. patients with elevated levels of different inflammation cytokines show a worse prognosis at the time of diagnosis. in women, ovarian and colon cancer are the main causes of peritoneal carcinosis and a comparison of these two different types of peritoneal invasion have not been conducted yet. we found interesting studying the role of immune response, in particular tumour-associated antigens (taa) that modulate the metastatic process. we will investigate also mitochondrial defects, such as mutations in mt-dna, potentially involved in carcinogenesis.

at the time of hospitalization all the patients will undergo a complete clinical evaluation with determination of biochemical parameters such as fasting blood glucose, blood count, hs-crp, ast and alt, uric acid, creatinine and bun. an extra blood aliquot will be collected to assess the serum biomarkers under investigation. during surgery two samples of peritoneal tissue macroscopically undamaged will be collected. on those samples will be executed separation of adipocytes cells, rna and protein extraction for measuring of inflammatory and neoplastic biomarkers, determination of p2x7r-inflammasome activity and mitochondrial dna analyse.

Eligibility criteria:
inclusion criteria: * histological diagnosis of peritoneal carcinosis secondary to colon cancer or high-grade ovarian cancer * patients able to consent exclusion criteria: * previous malignancies, except for patients with cutaneous basal cell carcinoma, cervical intraepithelial neoplasia (cin) or melanoma in situ * current chemotherapy or radiotherapy * current steroid therapy or immunotherapy * patients affected by systemic inflammatory disease and/or inflammatory bowel disease (ibd)

Keywords: peritoneal carcinomatosis colon cancer ovarian cancer p2x7r-inflammasome
effectiveness of therapeutic tactics of analgesia in patients with gunshot and mine-explosive wounds at the stages of treatment

Conditions: Chronic Pain

Summary: in 82.1% of patients with gunshot and mine-explosive wounds, pain becomes chronic, therefore, the study of the effectiveness of therapeutic tactics for pain relief in this category of patients at the stages of treatment will be important for improving the results of pain treatment.

the effectiveness of the therapeutic tactics of analgesia in patients with gunshot and mine-explosive wounds at the stages of treatment needs to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics. given that in 82.1% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in their treatment.

Eligibility criteria:
inclusion criteria: * the presence of gunshot wounds exclusion criteria: * no gunshot wounds

Keywords: pain treatment, analgesia, wounds, stages of treatment.
efficiency of the "medidux" smartphone app for demission management in patients medicated in acute admission unit (aau)

Conditions: Acute Disease; Acute Hospitalization; Coughing; Back Pain; Abdominal Pain (AP); Patient Discharge; Patient Readmission; Mobile Health Apps; Mobile Health Technology (mHealth); Patient Reported Outcome (PRO)

Summary: the goal of this clinical trial is to evaluate whether the use of the medidux™ smartphone app can optimize post-discharge management for patients admitted to acute admission units (aau) with non-urgent health complaints. this trial includes adult patients (age ≥ 18) in emergency severity index (esi) triage system groups 4 (standard) or 5 (non-urgent), presenting with primary symptoms such as cough, back pain, or abdominal discomfort. the main question it aims to answer is: can the medidux™ app reduce the incidence of aau readmissions, emergency hospitalizations, or consultations with other medical providers within 7 days after initial admission? researchers will compare participants using the medidux™ app (intervention arm) with those receiving standard care (control arm) to observe potential differences in the rates of readmissions, emergency hospitalizations, and medical consultations. participants will: * use the medidux™ app to monitor their symptoms and vital parameters for 7 days after discharge (intervention arm). * receive follow-up consultations at day 7 and at day 28 to assess symptom progression and any healthcare interactions (both arms).


Eligibility criteria:
inclusion criteria: * signed informed consent form (icf) * age ≥ 18 years * (self-)admission to the involved acute admissions unit (aau) * "lead symptom" identified as coughing, back pain or abdominal discomfort * participant within esi triage system group 4 (standard) and 5 (non-urgent) * german-speaking * ownership of a smartphone or other mobile device with ios or android operating system exclusion criteria: * age \< 18 years * participant whose compliance to the study's protocol, e.g. due to mental health problems, physical problems, or the private life situation, can be justifiably doubted * participant with insufficient knowledge about the use of a smartphone or other mobile device with ios or android operating system * participant already using or planning to use another comparable electronic patient-reported symptom monitoring system (e.g. cankado) during this trial

Keywords: acute disease patient discharge patient readmission coughing back pain abdominal pain mobile health applications remote monitoring post-discharge care symptom monitoring health behaviour telemedicine randomized controlled trial
prognostic factors of acute splenic sequestration

Conditions: Anemia; Drepanocytic

Summary: acute splenic sequestration is a frequent and life threatening complication occurring in approximately 10 % of homozygous children. maximal incidence is between 6 and 18 months. the investigators formulate the hypothesis that there are clinical, biological and genetic markers predictive of severe complications notably acute splenic sequestration in scd children. the present research project thus aims at analyzing in a forward-looking way the profile of severity by analysing clinical, biological and genetic characteristics in a multicentric cohort of 60 scd children

a prospective multicentric analysis will be conducted in a cohort of 150 ss or s ß ° children diagnosed at birth, included at 3 -5 months and followed up to the age of 24 months. five visits, superimposed to the usual follow-up of scd children, (recommendations of the high authority of health) at 3 months, 6 months, 12 months, 18 months and 24 months will allow a clinical evaluation and an additional sampling of blood (5 ml) at each visit. the samples will allow 1.analysis of the red blood cell phenotype (adhesion and deformability) and densities 2. the genetic profile 3.to establish a cell bank, a sera bank and a dna bank, spleen function in the cohort will be estimated by spleen scintigraphy, coupled with blood markers (pitted cells, howell-jolly bodies counts)

Eligibility criteria:
inclusion criteria : * children aged 3 to 6 months * homozygous (ss) or s beta° sickle cell disease diagnosed by neonatal screening * with no history of acute splenic sequestration * signed parental consent * patient covered by national insurance scheme or cmu exclusion criteria : * children with other scd genotype * children with congenital anatomical asplenia * children with previous episode of acute splenic sequestration * absence of possible follow-up * simultaneous enrolment in another biomedical research