Kornimate/medical-research-clean huggingface dataset:
immunoinflammatory state detection and multimodal brain imaging and electrophysiologic changes in schizophrenia

Conditions: Schizophrenia; Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Summary: schizophrenia is a severe mental illness that seriously affects the health and functioning of patients. previous studies have found immunoinflammatory abnormalities in the blood, cerebrospinal fluid, central nervous system, and neuroimaging of people with schizophrenia, along with therapeutic effects of anti-inflammatory drugs on schizophrenia. these evidences suggest a close relationship between schizophrenia and immunity and inflammation. therefore, we consider that the state of immune inflammation is a potential subtype classification basis for schizophrenia, and hypothesize that immune classification based on peripheral-central multidimensional data is related to patient's response to medication and cognition.

this is a single-center prospective cohort study with longitudinal follow-up of patients with schizophrenia and cross-sectional data from healthy controls matched for sex and age. participants who meet the inclusion and exclusion criteria will receive a 3-month follow-up with clinical information, biological samples, and imaging data collected at baseline, 1st and 3rd months. the aim of this project is to analyze peripheral-central immune-inflammatory performance and changes in patients with different clinical subtypes of schizophrenia through the use of scale assessments, biospecimen analysis, and imaging data. the positive and negative symptom scale (panss) is used to evaluate the patient's clinical status; matrics consensus cognitive battery (mccb) is used to assess cognition; biological samples such as blood and cerebrospinal fluid are used for multi-omics including immunohistology, inflammation-related molecules, single-cell sequencing, and extracellular vesicles; multi-modal imaging scans are used to react to the brain's structure, function, water molecule diffusion properties, and magnetization; eeg is used to react to the electrophysiological situation.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis that meets icd-11 criteria for schizophrenia. 2. confirmation of the diagnosis of schizophrenia using the scid-5-rv. exclusion criteria: 1. clinical diagnosis or scid-5-rv assessment confirming neurodevelopmental disorders, bipolar and related disorders, substance use disorders (excluding alcohol and tobacco). 2. presence of severe or acute physical illnesses, including traumatic brain injury, intracranial space-occupying or infectious diseases, acute cardiovascular diseases, acute respiratory system diseases, acute hematological disorders, autoimmune disease, etc. 3. presence of clearly defined genetic diseases, including tuberous sclerosis, multiple sclerosis, kleefstra syndrome, 22q11.2 deletion syndrome, prader-willi syndrome, klinefelter syndrome (47, xxy), etc.

Keywords: schizophrenia immunity inflammation
neurovascular navgation with remotely controlled deflectable guidewire, study ii (neuronav study ii)

Conditions: Unruptured Cerebral Aneurysm

Summary: the aim of the study is to confirm the safe and successful use of the smartguide guidewire, when used in neuro interventions. the performance of the smartguide guidewire in terms of safe and successful navigation within the neurovasculature will be compared to standard of care guidewire on the market.


Eligibility criteria:
inclusion criteria: * \>18 years of age * informed consent signed by the patient * confirmed cerebral unruptured aneurysm treatable via transcatheter approach exclusion criteria: * pregnancy or lactation * known disorder of vascular fragility with propensity to vascular injury (e.g., ehlers-danlos syndrome) * known prior vascular stenosis or dissection or injury to vessels intended to be catheterized during study procedures * acute phase myocardial infarction or uncontrolled cardiac arrhythmia * uncontrolled serum electrolyte imbalance * bleeding disorder which limits the use of antiplatelet and/or anticoagulant therapy * known contraindication to intravascular contrast material that cannot be adequately controlled with pre-medication * known hypersensitivity to nickel * subjects currently enrolled in another investigational device or drug study that clinically interferes with the current study endpoints
recovery optimization intervention to reduce the risk of injuries in soccer players

Conditions: Muscle Fatigue (C23.888.592.612.612); Athletic Injuries (C26.857.500.124); Recovery of Function (G11.427.698.620); Cryotherapy (E02.095.301.250); Thermotherapy (E02.095.301.750); Soccer (I03.450.642.845.750); Biomarkers (D23.050.301); Thermography (E01.370.350.700.750); Physical Fitness (G11.427.410.698)

Summary: the goal of this clinical trial is to evaluate if recovery interventions using cold and hot water immersion can reduce the risk of injuries in amateur soccer players. the main questions it aims to answer are: do cold water immersions reduce muscle fatigue and improve performance more effectively than hot water immersions? what is the optimal timing and duration for these recovery interventions to maximize their effectiveness? researchers will compare: cold water immersion (cwi) hot water immersion (hwi) no immersion (ni) thermographic immersion (ti) based on individual thermal profiles participants will: undergo thermographic assessments to determine their thermal profiles. perform physical tests such as isometric strength tests, countermovement jumps (cmj), and squats with 50% body weight. complete wellness questionnaires to assess their subjective recovery and fatigue levels. provide blood and urine samples for biomarker analysis. participate in recovery interventions (cwi, hwi, or ti) based on their assigned group.


Eligibility criteria:
inclusion criteria: age: participants must be adults (18 years or older). gender: both male and female participants are eligible. sport: participants must be amateur football players. team membership: participants must be members of a football team in the castilla-la mancha regional category. consent: participants must provide written informed consent to participate in the study. health: participants must be in good general health, with no chronic illnesses or conditions that would contraindicate participation in physical activity or water immersion. exclusion criteria: injury: participants who have sustained an injury that prevents them from participating in football activities for at least two weeks during any of the study blocks. medical conditions: participants with medical conditions that contraindicate water immersion (e.g., severe cardiovascular conditions, open wounds, skin infections). withdrawal: participants who choose to withdraw from the study at any point. non-compliance: participants who do not comply with the study protocol or fail to attend scheduled sessions. pregnancy: female participants who are pregnant or planning to become pregnant during the study period.

Keywords: muscle fatigue recovery interventions fatigue reduction recovery optimization physical performance
magnetic resonance imaging of brain development in autism

Conditions: Autism

Summary: the purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced mr techniques. we will use longitudinal diffusion tensor imaging (dti) measures to investigate the protracted development of long-range white matter fibers in autism. in addition, we will investigate the effect of autism risk genes on brain development.


Eligibility criteria:
inclusion criteria: 1. aged 6 - 18 years at initial mri inclusion criteria for subjects with autism 1) dsm-iv (apa, 1994) diagnosis of autism, according to adi-r interview inclusion criteria for controls 1. no dsm-iv (apa, 1994) diagnosis, according to disc interview 2. no scores in the clinical range on the child behavior checklist (cbcl) and teacher rating form (trf) 3. iq \> 70 exclusion criteria: 1. major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system 2. presence of metal objects in or around the body (pacemaker, dental braces) 3. history of or present neurological disorder 4. for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the information letter and on which the decision to participate in the study is to be based

Keywords: magnetic resonance imaging diffusion tensor imaging
mindfulness based eating awareness training for bariatric surgery patients

Conditions: Obesity, Morbid; Eating Disorder Symptom

Summary: the purpose of this study is to evaluate the effects of mindfulness based eating awareness training (mb-eat) for patients who have had bariatric surgery on their weight and mental and physical health compared to patients who do not do this group. all participants will complete questionnaires evaluating eating and mental health before and after the group and 6 and 12 months later. they will have blood pressure readings at these times and complete a questionnaire about their digestive health. our hypothesis is that participants will maintain their weight loss after bariatric surgery and have improvements in the other outcomes.

mb-eat may be helpful for reducing emotional eating, overeating and grazing, eating patterns that can lead to weight gain after bariatric surgery. participants will receive mb-eat 6 months or more following bariatric surgery. they will be randomly assigned to receive mb-eat right away or 8 weeks later. individuals in the group starting in 8 weeks will serve as a waitlist control group.the primary outcome measures will be changes in self-reported eating problems, depression, anxiety, and mindfulness. there will be a follow-up at 6 months and 12 months to establish stability of symptoms post-intervention. participants will receive one introductory information session about the mb-eat program, as well as 8 mb-eat scheduled consecutively over eight weeks. each session is approximately two hours in length. during mb-eat, participants will practice mindfulness to help improve their decision making abilities about when and how much to eat. through mb-eat, participants will learn to address mindless or out-of-control eating, which can lead to weight gain. homework will include daily meditations and mindful eating exercises.

Eligibility criteria:
inclusion criteria: 1. post-bariatric surgery patients recruited from the toronto western hospital-bariatric surgery program (twh-bsp) who are six months or more post-surgery, are experiencing self-reported difficulties adhering to post-surgery eating guidelines, and can commit to attending the group. 2. fluent in english. 3. have the capacity to provide informed consent. exclusion criteria: 1. active suicidal ideation. 2. active serious mental illness (i.e., psychotic disorder, bipolar disorder). 3. active severe depression (i.e., current major depressive disorder diagnosis and phq-9 score \> 20 \[severe depression\]). 4. active severe anxiety (i.e., current anxiety disorder diagnosis and gad-7 score \> 15 \[severe anxiety\]). 5. active symptoms of post-traumatic stress disorder (i.e., current diagnosis of post-traumatic stress disorder).

Keywords: mindfulness bariatric surgery obesity group psychotherapy
validation study of a watch for the detection of atrial fibrillation

Conditions: Atrial Fibrillation; Arrythmia, Cardiac

Summary: the proposed clinical study aims at validating the diagnostic performance, in comparison with a reference ecg, of withings hwa08 watch for the automatic identification of atrial fibrillation (af).


Eligibility criteria:
inclusion criteria: * adults, men or women, at least 18 years old * person having signed the informed consent form * person affiliated to a social security system exclusion criteria: * vulnerable subject according to current regulation: * pregnant woman, parturient or breastfeeding * subject deprived of freedom by judicial, medical or administrative decision * subject legally protected or unable to express his consent * subject non-beneficiary of healthcare * subject falling into more than one of the above categories * subject who refused to participate in the study * subject in linguistic or psychic incapacity to sign a written informed consent form * subject in physical incapacity to wear a watch on their wrist * subject with electrical stimulation by pacemaker

Keywords: atrial fibrillation arrhythmias, cardiac cardiovascular diseases heart diseases wearable electronic devices electrocardiography
comparison of ability of pcle and wle for diagnosis and cancer tissue acquisition in advanced gastric cancer after chemotherapy status

Conditions: Advanced Gastric Cancer; Neoadjuvant Chemotherapy; Palliative Chemotherapy

Summary: \* single center, prospective study first, evaluate the lesion under the white light endoscopy (wle) → iv fluorescein sodium 0.1ml/kg → evaluate the lesion under probe-based confocal laser microendoscopy → target biopsy under the pcle → random biopsy under wle

the purpose of this study is to conduct a study on genetic pathology, obtaining of cancer tissues is mandatory. although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer cells in biopsy samples of patients after chemotherapy is usually 30% or less. because cancer cells are often replaced with regenerative cells after chemotherapy, even though there are still remnant cancer cells in the stomach. recently, confocal laser endomicroscopy has been introduced for real-time histopathologic diagnosis in various cancers. in previous pilot study in our institution, pcle-targeted biopsy provided superior results in terms of the proportion of cancer cells in biopsy samples compared to wle-targeted biopsy, especially for gastric cancers with undifferentiated histology. however, there was no previous study about precious biopsy method for patients after chemotherapy. therefore, the investigators aim to evaluate that biopsy using probe-based confocal laser endomicroscopy for remnant gastric cancer after chemotherapy will increase the percentage of cancer cells and expression ratio of tumor marker in biopsy samples.

Eligibility criteria:
inclusion criteria: a. older than 20 years old and younger than 80 years old b. patients who completed neoadjuvant chemotherapy with agc c. patients who underwent palliative chemotherapy with agc exclusion criteria: a. previous subtotal gastrectomy b. previous emr/esd history c. significant cardiopulmonary disease d. active hepatitis or severe hepatic dysfunction e. severe renal dysfunction f. severe bone marrow dysfunction g. severe neurologic or psychotic disorder h. pregnancy or breast feeding

Keywords: pcle confocal advanced gastric cancer chemotherapy
impact of the covid-19 pandemic on mental health service utilization in children and adolescents

Conditions: Mental Disorder, Child

Summary: mental health consequences of the covid-19 pandemic may be vast and may potentially overwhelm the mental health system in a long-lasting manner. evaluating the effects of the covid-19 pandemic on mental health in vulnerable groups such as children and adolescents has become an immediate priority. the aim of this study is to evaluate the impact of covid-19 pandemic on use of mental health resources namely 1) prescriptions of psychotropic medications and 2) mental health-related outpatient visits, hospitalizations and emergency department visits in children and adolescents in france. secondary aim is to evaluate the impact of the pandemic on episodes of fatal and non-fatal self-harm episodes in the same population. this will be a population-based cohort study using data from healthcare claims, administrative medical and outpatient drug dispensation databases in france between january 1, 2016 and june 1, 2021. findings will inform on the risk of upcoming outbreaks of mental disorders that can result in significant morbidity and mortality and guide timely targeted actions to improve mental health outcomes and wellbeing in the youngest.

mental health consequences of the covid-19 pandemic may be vast and may potentially overwhelm the mental health system in a long-lasting manner. evaluating the effects of the covid-19 pandemic on mental health in vulnerable groups such as children and adolescents has become an immediate priority. the aim of this study is to evaluate the impact of covid-19 pandemic on use of mental health resources namely 1) prescriptions of psychotropic medications and 2) mental health-related outpatient visits, hospitalizations and emergency department visits in children and adolescents in france. secondary aim is to evaluate the impact of the pandemic on episodes of fatal and non-fatal self-harm episodes in the same population. this will be a population-based cohort study using data from healthcare claims, administrative medical and outpatient drug dispensation databases in france between january 1, 2016 and june 1, 2021. findings will inform on the risk of upcoming outbreaks of mental disorders that can result in significant morbidity and mortality and guide timely targeted actions to improve mental health outcomes and wellbeing in the youngest.

Eligibility criteria:
inclusion criteria: * children and adolescents aged from 6 to 18 years * one dispensation of psychotropic medication or * one mental-health related hospitalization or * one reimbursement for an outpatient mental-health related consultation or * one eligibility to long-term diseases corresponding to long term psychiatric diseases or * one mental-health related cause of death using icd-10 codes exclusion criteria: * none

Keywords: pediatrics covid 19 pandemic mental health psychotropic drug
evaluation of postoperative intracranial pressure in patients undergoing intracranial tumor surgery

Conditions: INTRACRANIAL TUMOR; INTRACRANIAL PRESSURE; OPTIC NERVE

Summary: ultrasonography(usg)-guided optic nerve sheath diameter measurement and its correlation with brain computed tomography in the evaluation of intracranial pressure in patients who underwent intracranial brain tumor surgery.

optic nerve sheath diameter (onsd) measurement is a non-invasive diagnostic method used to detect increased intracranial pressure, and in general, onsd measurement over 5 mm has been found to be associated with increased intracranial pressure.onsd will be measured using an usg device within the specified time periods. t0: before anesthesia induction t1: first 5 minutes immediately after induction of anesthesia t2: at the end of the surgery before extubation /minute t3: within the first hour/minute after extubation t4: 12 hours/minute after tumor resection t5. 24 hours/minute after tumor resection onsd measurement in brain computer tomography (bct); eyeball diameter and optic nerve diameter measurements will be made on bct transverse images at the optic nerve level and recorded.in patients, usg and bct correlation comparison is planned before the operation (t0), in the first hour after the end of post-operative surgery (t3) and at the 24th hour after post-operative surgery (t5). t0: onsd measurement in pre-operative brain ct t3: bct onsd measurement/minute within the first hour following the postoperative period t5: bct onsd measurement/minute 24 hours following the postoperative period

Eligibility criteria:
inclusion criteria: * patients over 18 -65 years * brain malignant neoplasm tumor * brain benign neoplasm supratentorial * brain benign neoplasm infratentorial information exclusion criteria: * patients who cannot provide adequate image quality in ocular ultrasonography * who are unconscious or have a glasgow coma scale of less than 15 * pseudotumor cerebri * optic nerve arachnoid cyst * patients with open injuries involving the eyelid and surrounding area * optic nerve malignant neoplasm * injury of the optic nerve and its pathways * systemic lupus erythematosis, * scleroderma * multiple sclerosis, sarcoidosis * thyrotoxicosis (hyperthyroidism)

Keywords: optic nerve intracranial pressure intracranial tumor intracranial tumor surgery intracranial pressure change
effect of virtual reality and progressive muscle relaxation on anxiety and attention among cardiac care unit patients

Conditions: Anxiety

Summary: this study aims to: assess the effect of virtual reality and modified progressive muscle relaxation distraction techniques on anxiety, attention and getting distracted from the external environment among cardiac care unit patients. research hypotheses: h1: patients who receive vr intervention have lower hamilton anxiety rating (ham-a) scores than those who receive modified pmr intervention. h2: patients who receive vr intervention exhibit improvement in their physiological parameters than those who receive modified pmr intervention. h3: patients who receive vr intervention have lower attention/distraction scores than those who receive modified pmr intervention.


Eligibility criteria:
inclusion criteria: * admitted to ccu for at least 3 days after stability, so they would have experienced ccu routines in all shifts. * diagnosed with cardiac disease. * aged from 18 to 60 years, from both genders. * patients who are conscious and stable condition. * patients without a history of neurological impairment such as motor, visual and auditory disabilities and psychological disorders. exclusion criteria: * patients staying in the ccu for less than 3 days. * who is unconscious or unstable condition. * sedated or refuse to participate. * have psychiatric diseases and receive psychological drugs.

Keywords: "attention" "distraction" "progressive muscle relaxation" "virtual reality"
a clinical study to assess the efficacy and safety of leriglitazone in adult male subjects with cerebral adrenoleukodystrophy

Conditions: Cerebral Adrenoleukodystrophy (cALD)

Summary: a clinical study to assess the efficacy and safety of leriglitazone in adults male subjects with cerebral adrenoleukodystrophy.


Eligibility criteria:
key inclusion criteria: * subject is male and aged ≥18 years. * subject has progressive cald, defined as gde+ brain lesions. * subjects for whom hsct is not recommended by the investigator or subject is not willing to undergo hsct. * subject has a loes score ≥0.5 and ≤12 at screening. * subject does not have major functional disability in the major functional disabilities-neurological function score (mfd-nfs), except for "wheelchair bound" or "total incontinence", which will be allowed as these are considered expected symptoms of amn in the time course of the disease * subject does not have major cognitive impairment which would impair his ability to take part in the study as determined by the investigator at screening. key exclusion criteria: * subject who had previous bone marrow transplantation (hsct) or treatment with ex-vivo gene therapy (eli-cel). * subject has known type 1 or type 2 diabetes. * subject has known hypersensitivity or intolerance to pioglitazone or any other thiazolidinedione. * subject is taking or has taken honokiol, pioglitazone, or other thiazolidinediones within 3 months prior to screening. * subject with current participation in another interventional clinical study or within 1 month prior to screening. * subject with other medical, neuropsychiatric or social conditions that, in the opinion of the investigator, are likely to adversely affect the risk-benefit of study participation, interfere with study compliance, or confound the study results.