Kornimate/medical-research-clean huggingface dataset:
endoscopic ultrasound (eus)-guided fine needle aspiration (fna) with rapid on-site evaluation (rose) of cytopathology vs. eus-guided fine needle biopsy (fnb) alone in the diagnosis of pancreatic solid lesions

Conditions: Solid Pancreatic Tumor

Summary: currently, the best way to evaluate pancreatic masses is through endoscopic-guided needle sampling of the mass to determine the diagnosis by looking at the acquired tissue under a microscope. this is done by inserting a small camera (endoscope) through the mouth of the patient then advanced to the stomach and using ultrasound guidance a sample of the pancreas can be acquired through the stomach. the sampling is usually done with a small needle called fine needle aspiration needle or fna. fna alone is sometimes limited due to inadequate acquisition of cells for proper diagnosis under the microscope, which can lead to need for repeat endoscopic procedures and delay in diagnosis and possibly treatment. rapid on-site evaluation of cytopathology (rose) is where a cytopathologist is next to the physician doing the endoscopic procedures and evaluates each sampling performed immediately under the microscope and can give feedback to the endoscopist until enough cells has been acquired for a diagnosis. this method has been shown to increase the ability to diagnose pancreatic cancer but is expensive and requires significant amount of resources. new needles called core needles (fine needle biopsy, fnb) have recently been developed which not only acquires cells but also the entire tissue structure (histology) and has been shown to be also very accurate in the diagnosis of pancreatic cancer. the purpose of this study is to compare endoscopy-guided biopsy of pancreatic masses with the new core needle (fnb), which can obtain more tissue for diagnosis vs. using a traditional needle (fna) with the help of an immediate assessment of the obtained samples under the microscope to determine whether enough tissue has been obtained (rose). both approaches have been shown to increase the accuracy of diagnosis in solid pancreatic masses but it is unclear which one is superior. this is a randomized trial meaning that the participants would either undergo biopsy with the new needle or with the traditional needle plus the addition of on-site assessment of the obtained samples. the advantage of the new needle is that it is easy to implement and likely much cheaper. if the investigators can show in our study that the new needles are as accurate as fna with rose then fnb could be implemented across hospitals worldwide in an easier and less expensive fashion.


Eligibility criteria:
inclusion criteria: * age \> 18 years * patients referred for eus evaluation of a definite solid pancreatic mass noted on computed tomography(ct)/magnetic resonance imaging(mri)/eus, in which malignancy is suspected with no previous histological diagnosis exclusion criteria: * age \< 18 years, pregnant patients. * uncorrectable coagulopathy prothrombin time (pt) \>50% of control, partial thromboplastin time (ptt) \>50 sec, or international normalized ratio (inr) \>1.5 and/or uncorrectable thrombocytopenia platelet count\<50, 000109/l.
examining the effect of virtual reality on pain and anxiety management during pelvic examination

Conditions: Pelvic Examination,Virtual Reality

Summary: objective: the study was conducted as a randomized controlled experimental study to examine the effect of the video watched with virtual reality glasses during the pelvic examination on the level of pain and anxiety perceived by women. materials-methods: the sample of the study consisted of 128 women (64 experimental, 64 control group) who applied to the obstetrics and gynecology polyclinics with non-pregnancy complaints between november 2021 and february 2022, volunteered to participate in the study and were approved by the doctor for pelvic examination. institutional and ethical committee permissions were obtained before starting the study. descriptive information form, state anxiety scale, visual comparison scale (gds), pelvic examination experience evaluation questionnaire, and questionnaire evaluating non-verbal responses to emotional stressful situations, prepared by the researcher, were used to collect data. in the pre-test to the women in the experimental group of the study: descriptive information form, state anxiety scale, visual comparison scale (for anxiety), then pelvic examination + virtual reality application (using virtual reality glasses for a minimum of 5 maximum 15 minutes), emotional stress to be applied by the researcher the form evaluating non-verbal responses to the creating situations, and in the post-test: state anxiety scale, visual comparison scale (anxiety + pain), pelvic examination experience evaluation questionnaire were applied. in the pre-test to the women in the control group of the study: introductory information form, state anxiety scale, visual comparison scale (for anxiety), then pelvic examination (routine service), form evaluating non-verbal responses to emotional stressing situations to be administered by the researcher, in the post-test: state anxiety scale, visual comparison scale (anxiety + pain), pelvic examination experience evaluation questionnaire were applied. data were evaluated in computer environment and using spss 23.0 statistical package program. a p value of \<.05 for the data was considered statistically significant.


Eligibility criteria:
inclusion criteria: * being between the ages of 18-40 * being able to read and write * to be competent to express oneself * having applied to the outpatient clinic for any gynecological complaint (bleeding, menstrual cycle irregularity, discharge, itching...) or for routine gynecological control. exclusion criteria: * having a current pregnancy * complaining of acute pelvic pain * having any damage or lesion in the perineum that may cause pain during the examination * having used a pharmacological agent or method with analgesic or anxiolytic effect 24 hours before the examination * having a vaginismus problem * having any physical or mental problems that may prevent communication

Keywords: pelvic exam pain anxiety virtual reality
efficacy and safety of nexpowder™ for non-variceal, upper gastrointestinal bleeding

Conditions: Gastrointestinal Hemorrhage; Hematemesis; With Ulcer; Endoscopy

Summary: the purpose of this pilot clinical trial is to confirm the efficacy and safety of nexpowder™ for hemostasis in pilot cohort of patients with nvugib in singapore

24 subjects with non variceal bleeding will be enrolled. the efficacy and safety of nexpowder™ as primary technique of endoscopci hemostasis will be assessed in this pi,ot study.

Eligibility criteria:
inclusion criteria: 1. males or females aged over 21 to 75 years 2. patients with confirmed nonvariceal, upper gastrointestinal bleeding 3. patients who voluntarily agree to the clinical trial with informed consent 4. patients who willing and able to comply with the study protocol exclusion criteria: 1. patients with an uncorrected coagulation disorder (plt\ 2) 2. patients who are known to be pregnant or in lactation 3. patients who have received another endoscopic treatment for the same part of the body within the days preceding the study 4. patients for whom endoscopic treatment is prohibited due to comorbidity 5. patients for whom the 30-day follow-up period is impossible 6. patients who have participated within the past month in other related clinical trials that could affect the results of the study 7. other cases in which participation in the study is judged inappropriate by the investigators

Keywords: gastrointestinal bleeding; hemostatic powder
ed90 for hyperbaric bupivacaine in super obese parturients

Conditions: Obesity, Morbid; Spinal Anesthesia; Cesarean Delivery

Summary: the aim of this study is to determine the ed90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.


Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) class 2 and 3 * english speaking * gestational age \> 36 weeks * scheduled for cesarean delivery under combined spinal epidural anesthesia * 18 years or older * bmi \> 50 kg/m2 exclusion criteria: * history of past or current intravenous drug or chronic opioid abuse * allergy or contraindication to any study medications * intrapartum cesarean delivery under epidural anesthesia * cesarean delivery under general anesthesia

Keywords: bupivacaine ed90 cesarean delivery obesity spinal anesthesia
ketoconazole foam 2% for the treatment of versicolor

Conditions: Tinea Versicolor

Summary: ten adult patients age 19 and older with a clinical diagnosis of tinea versicolor, as well as a positive potassium hydroxide (koh) using calcofluor. ketoconazole 2% foam will be used to determine its effectiveness, safety and satisfaction when used to treat tinea versicolor.

objectives 1. to assess the efficacy of ketoconazole 2% foam for the treatment of tinea versicolor 2. to assess the safety of ketoconazole 2% foam for the treatment of tinea versicolor based on the occurrence of adverse events. 3. to assess treatment satisfaction as rated by patients study design: this will be a mono-centered, single arm, open-label pilot study. ten adult patients age 19 and older with a clinical diagnosis of tinea versicolor, as well as a positive koh using calcofluor, will be enrolled at the university of alabama at birmingham. there will be 4 scheduled visits (baseline, week 1, week 2, and week 4). a target area will be identified and mycological and clinical assessments will be performed at this site as well as a global assessment of each subject. ketoconazole 2% foam will be applied to all affected areas for 2 weeks with a follow-up visit at week 4. skin scraping using a disposable #15 blade for calcofluor/potassium hydroxide (koh) assessment and photographs of target lesions will be performed at baseline, week 1, week 2, and week 4. photographs will be taken at baseline and at week 4 (only if koh is positive). body surface area estimation of disease will also be performed at each visit. evaluation of scale, hyperpigmentation/erythema, and hypopigmentation using a 4 point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe) of the target area will be performed at baseline, week 1, week 2, and week 4. a global assessment will be conducted at each visit using the same 4 point scale. patient questionnaires will be administered at baseline and week 2 to assess symptoms and satisfaction with study medication.

Eligibility criteria:
inclusion criteria: 1. male or female patients, aged 19 years and over. 2. clinical presentation of tinea versicolor. 3. positive koh using calcofluor. 4. the ability to provide informed consent (including photography release) exclusion criteria: 1. use of topical antifungal to the affected area in the past 30 days 2. use of topical steroid to the affected area in the past 14 days 3. if female, positive urine pregnancy test at screening (female patients of childbearing potential must be practicing a reliable method of birth control, not be planning a pregnancy, not be breast-feeding during the study) 4. patients with a dermatologic condition in the region of the treatment site that in the investigator's opinion may interfere with the study results 5. current diagnosis of immunocompromising conditions 6. any medical or psychiatric condition that may interfere with treatment or compliance

Keywords: tinea versicolor ketoconazole
screening for abdominal aortic aneurysm and abdominal aortic atherosclerosis by hand-held ultrasonography

Conditions: Hypertension; Abdominal Aortic Aneurysm; Atheromatosis

Summary: the purpose of this study is to determine the prevalence of abdominal aortic aneurysm (aaa) and abdominal aortic atheromatosis (aa-at) using a hand-held ultrasound by a general practitioner in primary health care.

pilot study that prospectively study a cohort of men over 50 years with cardiovascular risk factors: active smokers, former smokers, or hypertensive patients, attended in primary health care center. general practitioner complete an ultrasonography training in an ultrasound unit under supervision of experienced radiologists using an standard ultrasound equipment and hand-held ultrasound (trademark: vscan®, manufacturer: general electric, usa). all images and video recorded are blindly evaluated by a radiologist in order to establish the concordance in the interpretation of images between general practitioner and radiologist. kappa index is calculated to study the agreement on the presence or absence of aaa and aa-at. logistic regression analysis is used to determine the factors that influence the presence of aa-at

Eligibility criteria:
inclusion criteria: * smokers * former smokers. * hypertensive patients

Keywords: hand-held ultrasonography abdominal aortic aneurysm abdominal aortic atherosclerosis cardiovascular risk primary health care
chinese cardiologists' knowledge/practices on flu vaccine for chronic coronary syndrome

Conditions: Chinese Cardiologists

Summary: this long-term single-center cross-sectional study evaluates physicians' knowledge of influenza vaccination in ccs patients through collected feedback, while identifying knowledge gaps and misconceptions regarding vaccination. by analyzing factors influencing physicians' recommendation practices, it provides evidence to guide future educational and policy interventions. ultimately, the study aims to enhance cardiologists' vaccination awareness, thereby optimizing ccs patient management and reducing influenza-associated complications and mortality.

this project conducts a comprehensive literature review to examine current research and practices regarding influenza vaccination for chronic coronary syndrome (ccs) patients among cardiologists worldwide. the review provides theoretical support for study design and helps identify potential causes of low vaccination rates among ccs patients in china.based on research objectives, investigators developed a structured questionnaire covering four key dimensions:basic demographic information、knowledge assessment、clinical practice patterns、attitudes and recommendations.the survey targets cardiologists from major chinese hospitals, employing random or stratified sampling to ensure representative sampling. data collection will be conducted through online and offline questionnaire distribution.statistical analysis will be performed using spss or equivalent software, including:descriptive statistics、t-tests、chi-square tests to examine how different background factors influence knowledge and practices.findings will systematically summarize chinese cardiologists' current understanding and behavioral patterns regarding influenza vaccination for ccs patients.

Eligibility criteria:
inclusion criteria: cardiologists (licensed practitioners) with specialized knowledge of the association between influenza vaccination and cardiovascular diseases. exclusion criteria: * physicians from non-cardiology specialties (e.g., surgery, general internal medicine \[including respiratory and gastroenterology departments\], emergency medicine). * physicians unable to complete the questionnaire survey.

Keywords: chronic coronary syndrome chinese cardiologists knowledge survey
virtual guided tour of the mmfa for prevention of social isolation

Conditions: Social Isolation; Well Aging; Quality of Life; Healthy Aging

Summary: it has previously been reported that participatory art-based activities may improve social inclusion, well-being, quality of life and health condition. findings from the investigator's first study seem to confirm that the mmfa participatory art-based activity may improve well-being, quality of life and health condition in older community dwellers. however, these studies were performed before the covid-19 crisis and were guided tours performed at the mmfa. a pilot study on virtual guided tour has been performed during covid-19 pandemic (spring 2021). there is a need to confirm benefits with a randomized clinical trial. the hypothesize for this study is that a 3-month cycle of virtual weekly mmfa tours may induce changes in social isolation, well-being, quality of life and health condition (i.e., reduction of frailty) in older community dwellers. because there is a positive correlation between severity of frailty and the occurrence of undesirable events like emergency department (ed) visits and hospitalizations, the investigator hypothesizes that virtual guided tours may decrease the frequency of ed visits and hospitalizations.


Eligibility criteria:
inclusion criteria: * age 65 and over; * having a low level of social inclusion defined with the 11-item duke social support index (dssi) score ≤ 26/3323; * living in quebec, at home in an urban area; * reading, understanding and writing the languages of the recruitment centre (i.e., french or english or chinese mandarin) because all the questionnaires are available in french, in english and in chinese mandarin, and because the guides of the museum performing the virtual guided tours speak french and/or english, with a translator in chinese mandarin. * having an internet access and an electronic device (smartphone, laptop, computer and/or tablet with a functional cam) at the participant's place of living as the repetitive assessments for this study will be performed on the web platform of the criugm, and the guided tours will be virtual. exclusion criteria: * cannot participate to a clinical trial at the same time, to avoid interferences with the outcomes of the studied intervention in this protocol. * having participated to a participatory art-based activity of the mmfa during the 3 month-period before the recruitment. a participation to any other museum activities may be assimilate to an intervention. as it could interfere with our outcomes, participants are not allowed to participate to any other museum activity, in any museum, during their 3-month participation. we previously showed that museum activities may change the outcomes studied in this study.
self-collection of the pap smear as agency: a novel way to improve refractory low cervical cancer screening rates in rural alabama

Conditions: Cervical Cancer

Summary: the purpose of the study is to find out if a self-administered (by the patient) papanicolaou (pap) smear is as accurate as a traditional pap smear administered by a healthcare provider.

papanicolaou (pap) smears will be both self-obtained by the patient and obtained by a licensed physician, nurse practitioner, or physician assistant. specimens will then be collected by the nurse or medical assistant who will label each specimen separately. specimens will be blinded so that the pathologist will not know which specimen was self-collected and which provider-collected. specimens will then be sent to our clinical laboratory provider (labcorp) for analysis. once results from the pap smears are received, participants will be notified in the usual manner in our clinical practice. finally, analysis will be conducted to ascertain whether or not a self-administered (by the patient) pap smear is as accurate as a traditional pap smear administered by a healthcare provider.

Eligibility criteria:
inclusion criteria: * female of at least 21 years of age and not over 65 presenting who need routine cervical cancer screening per national guidelines. exclusion criteria: * prior history of cervical cancer or a positive pap smear, have had a total hysterectomy (removal of uterus and cervix), or currently enrolled in any other cancer prevention study.

Keywords: pap smear papanicolaou self-collection cervical cancer screening
lifestyle intervention in patients with new onset type 2 diabetes.

Conditions: Type 2 Diabetes

Summary: the study seeks to establish if weight loss achieved through a program of intensive lifestyle management can result in improvements in glp-1 and glycaemic control, in patients with newly diagnosed type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * new onset type 2 diabetes * body mass index 25 and above * able to give informed consent exclusion criteria: * hypoglycaemic and antiobesity agents, or any other prescription medication that may interfere with study results
effect of wearing a compression sock during running on muscle soreness in distance runners.

Conditions: Muscle Soreness; Perceived Recovery; Perceived Exertion; Affective Response; Heart Rate

Summary: running is the most popular physical activity worldwide. although running provides many health benefits, it is often associated with injuries and symptoms such as delayed onset muscle soreness. there is still a paucity of interventions that can effectively minimise these symptoms in distance runners.

our primary aim is to explore the effect of compression socks during running on delayed onset muscle soreness after running. our secondary aims are to explore the effects of compression socks during running on perceived recovery, perceived exertion, affective response, and heart rate after running. this is a randomised, double-blind, sham-controlled crossover trial. forty-four participants will be recruited via social media, running clubs and the running coaches' network of the research team. participants will be randomised to complete a running protocol under two conditions (compression socks or sham socks). after that, there will be a wash-out period of 7 to 10 days, and participants will repeat the running protocol under the other conditions. primary outcome: lower limb muscle soreness will be collected, using a 0-100 numerical pain scale, immediately, 24 hours and 48 hours after the running protocol, with 24 hours post-protocol being the primary timepoint. secondary outcomes: perceived recovery will be collected, using a 0-10 scale immediately, 24 hours and 48 hours after the running protocol. perceived exertion, affective response, and heart rate will be registered only immediately after the protocol. between-group differences will be explored using linear mixed models.

Eligibility criteria:
inclusion criteria: * run consistently in the last six months (at least three times a week and at least 10 kilometres per week); * runners who did not run further than 42 kilometres in the last month. exclusion criteria: * pregnancy; * any lower limbs fracture in the last 12 months; * history of lower limb arthroplasty or osteotomy, previous venous thrombosis, kidney disease; * any running-related injury in the last six months. a running-related injury will be considered the presence of lower limb pain that caused restriction, stoppage of running (distance, speed, duration, or training) for at least seven days or three consecutive scheduled training sessions or the need for a health professional treatment

Keywords: runner garments pain stocking knee sports