Kornimate/medical-research-clean huggingface dataset:
urdu version of cornell musculoskeletal discomfort questionnaire: reliability and validity study

Conditions: Musculoskeletal Pain

Summary: the study aims to translate and adapt cornell musculoskeletal discomfort questionnaire cross-culturally into the urdu language for the pakistani population for investigating the reliability and validity of cornell musculoskeletal discomfort questionnaire in the pakistani population and to study the correlation between nordic musculoskeletal questionnaire and the visual analogue scale.

the english version of the cornell musculoskeletal discomfort questionnaire will be translated into urdu and culturally adapted, as per a previous recommendation. the cornell musculoskeletal discomfort questionnaire will be given to one hundred and fifty workers of masood textile mills, who would be chosen based on convenience sampling and inclusion and exclusion criteria. the inter-observer and intra-observer reliability of the cornell musculoskeletal discomfort questionnaire, nordic musculoskeletal questionnaire, and visual analog scale will be evaluated in this study. on the same day, the questionnaire will be filled out created two times. an inter - observer assessment will be done with 2 hour break between distributions of questionnaires. the initial observer then will gather a third assessment over one-week period (intra-observer assessment). for data entry and analysis, statistical package of social sciences version 24 will be utilized. internal consistency will be checked using the cronbach alpha value, and test retest reliability will be assessed using the intraclass coefficient.

Eligibility criteria:
inclusion criteria: * participants having an age limit of 18 to 55. * could read and understand the urdu language. * both males and females working more than 6 hours in sitting and standing positions. exclusion criteria: * having any fracture in any part of the body. * having any congenital or acquired disability that restricts them in their daily living.

Keywords: cornell musculoskeletal discomfort questionnaire factory workers reliability validity musculoskeletal discomfort
vascular and neurologic exploration of small nervous fiber by sudoscanner and qst

Conditions: Erythermalgia

Summary: erythromelalgy (em) is a vascular syndrome very rare affecting the feet. this disease evolve by crisis when the feet extremities become red hot and painful. there are several types of em but this study concern the adult primitive form. for a long time, the physiopathology was not described but now we know that there is a vascular form, with microcirculatory dysfunction and a neurologic form with small fibers neuropathy. the diagnostic of neurologic form is based on clinical evaluation (dn4 questionnaire, uens scale...) and an electromyography. thermotest, a medical device which measure the thermic sensitivity is used to quantify neuropathy. more recently sudoscan, a device measuring cutaneous impedance to chloride ions detect small nervous fiber in diabetic patients with good correlation with thermotest. the purpose of this study is to analyze the vascular side and the neurologic side on patients consulting for erythromelalgy.


Eligibility criteria:
inclusion criteria: * pain with burn feeling at hands and feet extremities * crisis activated by the heat * age \> 18 years old exclusion criteria: * patients who had burn in extremities
regional anesthesia for cardiothoracic enhanced recovery

Conditions: Opioid Use; Anesthesia, Local; Cardiac Disease; Pain, Acute

Summary: the erector spinae plane block (espb) is a novel regional analgesic technique that provides pain relief with a peripheral nerve block catheter. the goal of this study is to see if bilateral espb catheters can improve clinical outcomes in patients undergoing cardiac surgery via sternotomy, such as decreasing the duration of postoperative mechanical ventilation, need for intravenous opioid medications, length of stay in the intensive care unit (icu), and improving pain scores.


Eligibility criteria:
inclusion criteria: * give consent to participate in study * planned sternotomy * specific procedures: cabg (coronary artery bypass grafting) or avr (aortic valve repair or replacement) or mvr (mitral valve repair or replacement) or combination of any of 2 of these * primary or first redo sternotomy exclusion criteria: * participants who cannot give consent * patients who are clinically unstable or require urgent/emergent intervention * more than1 prior sternotomy * planned aortic arch procedures * preoperative coagulopathy (inr \>1.5, ptt \>35) or ongoing anticoagulation (heparin infusion, therapeutic low molecular weight heparin, warfarin, dual antiplatelet therapy) * severe ventricular dysfunction (left or right ventricle) * symptomatic heart failure (systolic or diastolic)
effect of a transitional pharmacist intervention in geriatric inpatients on hospitals visits after discharge

Conditions: Drug-Related Side Effects and Adverse Reactions

Summary: a randomized controlled trial will be performed in geriatric inpatients to investigate the impact of a multifaceted clinical pharmacy intervention on health related outcomes.

since drug-related harm remains persistently prevalent in older adults, there is an urgent and unmet clinical need to optimize pharmacotherapy both during hospital stay and after discharge therefore, we aim to perform a randomized controlled trial in geriatric inpatients to investigate the impact of a multifaceted clinical pharmacy intervention on health related outcomes. the primary objective is to reduce all-cause unplanned hospital visits in geriatric inpatients. secondary objective are to optimize drug therapy in geriatric inpatients and improve their health; to empower and educate patients, caregivers,community pharmacists and physicians regarding drug regimen decisions to maximize therapy adherence and the understanding of the (de)prescribing process and to enhance healthy ageing; to optimize transitional care from the hospital to primary care.

Eligibility criteria:
inclusion criteria: * patients admitted to one of the study wards under supervision of a geriatrician * a written informed consent by the patient or his/her representative * discharged from the hospital exclusion criteria: * admitted for a maximum of one day * unable to understand dutch * being in a palliative stage as stated in their medical record with active withdrawal of drug therapy * patients being discharged to another ward within the same hospital or to another hospital

Keywords: older patients inappropriate prescribing clinical pharmacy
age and sleep apnea syndrome

Conditions: OSA; Age Problem

Summary: by clinical record review, this retrospective study aims to compare the different age groups of patients with obstructive sleep apnea, who were diagnosed and treated in taipei veterans general hospital, taiwan.

this retrospective study aims to compare the characteristics of patients with obstructive sleep apnea (osa). patients with sleep problem and received a prior polysomnography at taipei veterans general hospital during jan. 1, 2016 to dec. 31, 2017 will be enrolled. obstructive sleep apnea (osa) is defined by an apnea-hypopnea index(ahi) at least 5/hr with compatible symptoms. their clinical record will be reviewed and data including demography, polysomnography, comorbidities and details related to upper airway structure will be collected. the charactereistics would be compared with student's t tests, mann-whitney u tests, or chi square tests if appropriated.

Eligibility criteria:
inclusion criteria: * patients with sleep complaints and received psg in sleep center in taipei veterans general hospital exclusion criteria: * patients who ever received treatment for osa * patients cannot tolerate psg examination * patients cannot complete the questionnaires before and after psg examination
non stress test and music performance

Conditions: Fetal Health; Pregnancy Related

Summary: today, many methods are used in the evaluation of intrauterine fetal well-being. non-stress test (nst) method is mostly used in the non-invasive evaluation of fetal well-being during pregnancy and labor. nst is a procedure in which fetal heart sounds are recorded and the relationship between fetal movements and fetal heart beat is monitored.3 various methods are used to minimize the psychological effects that occur during pregnancy. among these methods, it has been seen in the studies in the literature that music, which is a non-pharmacological method, has a positive effect on the pregnant woman and the fetus. it is easy and enjoyable to listen to music during the routine non-stress test process. however, there are not enough studies to prove the effect of music. the aim of this study was to examine the effects of the music concert applied during the nonstress test procedure on the health of the fetus, the anxiety level of the pregnant woman and blood pressure.

expected

Eligibility criteria:
inclusion criteria: * become literate * be in the 18-45 age range. * being at the 32nd and above gestational week * not carrying any risk factors during pregnancy (preeclampsia, iugr, gestational diabetes, etc.) * have eaten at least two hours before the nst procedure * no fetal defined cardiovascular disease * the pregnant woman is open to communication and does not have mental or mental problems. * absence of auditory problems exclusion criteria: * absence of illiteracy of the pregnant woman * uterine contraction in nst * pregnant women who need fetal distress and urgent intervention by the physician

Keywords: music pregnancy nonstrest test fetal health
3mixtatin and mta vital pulpotomy in primary molars

Conditions: Pulp Disease, Dental; Deciduous Teeth

Summary: the aim of the study is to evaluate clinical and radiographic success of using 3mixtain versus mineral trioxide aggregate in pulpotomy of deeply carious primary molars.

due to the complexity of the root canal microbiome, it is doubtful that they can be treated properly with a single antibiotic. accordingly, a combination of multiple antibiotics seemed to be essential to diminish different types of pathogenic bacteria. recently, a combination of three antibiotics (metronidazole, cefixime, and ciprofloxacin) along with statins (new bio-inductive materials in regenerative dentistry) has shown promising results in primary teeth pulp therapy. statin components have an anti-inflammatory impact on pulp tissue by lowering the amount of interleukin-6 and interleukin-8. they also decrease osteoclastic processes and strengthen osteoblastic processes. thus, they promote bone regeneration and dentin formation by enhancing odontoblastic activity. several studies have shown a clinical and radiographic success rate of 3mixtatin with inconsistent results. some randomized controlled trials (rcts) showed that mta had a comparable result with 3mixtatin, while others reported that 3mixtatin might be an alternative for mta due to its higher overall success rate. 3mixtatin is considered as a novel material with successful outcomes. owing to limited availability of data in researches and in order to reach a conclusive results our study aims to evaluate clinical and radiographic success of using 3mixtain versus mineral trioxide aggregate in pulpotomy of deeply carious primary molars .

Eligibility criteria:
inclusion criteria: * • children 4-8 years old * vital deeply carious primary molars. * no history of spontaneous pain, pathologic mobility, draining sinus tract, redness or swelling of the vestibule. * normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test. * patient and parent showing cooperation and compliance. exclusion criteria: * • uncooperative children to avoid time waste and attrition bias. * unrestorable molars * sign of radiolucency in periapical or furcation area * widening of pdl space or loss of lamina dura continuity * evidence of internal/external pathologic root resorption * during operative procedure, when hemorrhage control is not achievable after pulpotomy. * children with systemic disease as some systemic diseases may have effect on the outcome. * unable to attend follow-up visits to avoid attrition bias by decreasing number of drop off cases. * refusal of participation as the parent of child has the authority of participation.

Keywords: pulpotomy - vital pulp therapy primary molars- baby teeth
preliminary study of pediatric diaphragmatic elastography

Conditions: Congenital Diaphragmatic Hernia

Summary: this diaphragmatic elastography study is a preliminary pilot study to have first values of diaphragmatic stiffness in patients with a history of diaphragmatic hernia and to estimate the difference in stiffness compared to a group of patients without a history of hernia. the hypothesis is to be able to correlate the values found with the patients' symptomatology and thus to better monitor patients by a simple, accessible, painless and reproducible diagnostic tool, to better understand their evolution and even to be able to anticipate possible difficulties (reflux, respiratory disorders, scoliosis, etc.). ultrasound elastography is a recent and clinically recognized method that uses an ultrasound approach to determine tissue stiffness in a non-invasive way.


Eligibility criteria:
inclusion criteria: * group hdc: * patient followed at the ccmr (centres de compétence maladies rares) hdc of the strasbourg university hospital * aged between 3 and 17 years old inclusive * indifferent sex * subject affiliated to a social protection health insurance scheme or beneficiary of such a scheme * subject able to understand the objectives and risks of the research and to provide dated and signed informed consent * subject who has been informed of the results of the preliminary medical examination control group: * subject followed in pediatric surgery * aged between 3 and 17 years old inclusive * indifferent sex * subject affiliated to a social protection health insurance scheme or beneficiary of such a scheme * subject able to understand the objectives and risks of the research and to provide dated and signed informed consent * subject who has been informed of the results of the preliminary medical examination exclusion criteria: * group hdc: * refusal * language barrier * diaphragmatic surgery within the last 3 months * patient with a viral picture in progress at the time of examination (assessment by the investigator) * patient treated with muscle relaxant * inability to give the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.) * subject under safeguard of justice * subject under guardianship or curatorship * pregnant or breastfeeding woman control group: * patient without thoracic pathology * refusal * language barrier * diaphragmatic pathology * any myopathy * history of surgery of the upper digestive tract (esophagus and/or gastric and/or duodenal) * patient on muscle relaxant * patient with a viral picture in progress at the time of examination (assessment by the investigator) * patient treated with muscle relaxant * inability to give the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.) * subject under safeguard of justice * subject under guardianship or curatorship * pregnant or breastfeeding woman

Keywords: congenital diaphragmatic hernia ultrasound elastography chronic respiratory diseases pulmonary hypertension hypoplasia
human fresh corneal lenticule implantation criteria in progressive corneal disease using relex-smile

Conditions: Progressive Disease of Corneae

Summary: stroma is a fibrous, tough, transparent and the thickest layer of the corneae. the stroma is composed of organised collagen, which maintains transparency. keratocytes are located between the lamella collagen fibers and secrete an extracellular matrix, which includes collagen, proteoglycan, crystalline proteins to maintain corneal transparency.

knowing the importance of stroma(90%) in function and anatomy of corneae (transparence, curvature, strength, protection) the inner eye structures from external environment, we have examined the role and function of stroma as a main factor of corneal thickness in implanting fresh corneal lenticule in progressive corneal disease. we have studied that in many clinical cases where the corneal epithelium and endothelium are healthy and functioning, the cornea can still lose it's transparency by different corneal stromal pathologies (infection ,keratoconus, inflammation ,neurodegeneration and corneal dystrophies).

Eligibility criteria:
inclusion criteria: * progressive corneal disease with thin corneal thickness * corneal low transparenc * low visual acuity exclusion criteria: * active anterior segment pathology * previous corneal or anterior segment surgery * other infection etc.
choroidal blood flow response to hand-grip test in progressive glaucoma

Conditions: Primary Open Angle Glaucoma

Summary: the present study is designed to compare the response of choroidal blood flow to the hand-grip test in glaucoma patients with and without visual field progression.

glaucoma is a worldwide leading cause of blindness. the key features of glaucoma are damage to the optic nerve head and progressive visual field defect, which is not necessarily only related to an increase in intraocular pressure. it has been suggested that ocular blood flow alterations in glaucoma are related to systemic vascular dysregulations.the hand-grip test has been suggested as a potential tool to unravel vascular dysregulation in the ocular circulation. although applied routinely in clinical practice, a proper study testing the effectiveness of this test is lacking. the present study is designed to compare the response of choroidal blood flow to the hand-grip test in glaucoma patients with and without visual field progression.

Eligibility criteria:
inclusion criteria: patients fulfilling two out of three of the following criteria in one or both eyes: a) typical glaucomatous disc, b) visual field damage (a cluster of three points (except rim points) in at least one hemifield reduced by 5 db or greater and including at least one point reduced by 10 db or greater; a cluster of two points reduced by 10 db or greater; or three adjacent points on the nasal horizontal meridian that differed by 5 db or greater from their mirror points on the opposite side of the meridian), c) intraocular pressure above 21 mm hg at least at one occasion. furthermore, patients need to have a series of at least 5 visual field examinations, after exclusion of the first test, for assessment of progression. - exclusion criteria: * ametropia \> 3dpt * inadequate transparency of ocular media as defined by physical examination * iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy * any abnormality which in the physician's view would prevent reliable applanation tonometry or ldf of at least one eye * history of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis * history of ocular trauma or intraocular surgery within the past 6 months * history of infection or inflammation within the past 3 months * history of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment * patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study).

Keywords: visual field progression choroidal blood flow
high flow in infants with bronchiolitis

Conditions: Bronchiolitis

Summary: in this multi-centre randomized controlled trial the investigators compare the effect on dyspnoea severity of oxgen delivery through high flow nasal cannula with low flow nasal prongs in children \< 2 years of age hospitalised for bronchiolitis with moderate-severe dyspnoea.

in this multi-centre randomized controlled trial the investigators compare the effect on dyspnoea severity of oxgen delivery through high flow nasal cannula with low flow nasal prongs in children \< 2 years of age hospitalised for bronchiolitis with moderate-severe dyspnoea. the study will take place on the pediatric (non intensive care) units of 5 different hospitals in the netherlands.

Eligibility criteria:
inclusion criteria: * bronchiolitis pews (pediatric early warning score 0-28) \>= 6 oxygen saturation \< 92% exclusion criteria: * chronic lung disease hemodynamic significant heart disease syndromal disease facial abnormalities
a study of the safety and pharmacokinetics of cnto 136 in patients with cutaneous lupus erythematosus and systemic lupus erythematosus

Conditions: Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic

Summary: the main purpose of this study was to evaluate the safety and pharmacokinetics (pk, the action of a drug in the body over a period of time) of multiple intravenous (iv) administrations of cnto 136 in patients with cutaneous lupus erythematosus (cle) and systemic lupus erythematosus (sle). the secondary goal of this study was to assess the pharmacodynamics (biochemical and physiological effects of a drug and the mechanisms of action), immune response, and clinical response.

in part a of this study, patients with cle were randomly assigned (like flipping a coin) to receive multiple iv doses of cnto 136, a human anti-il 6 monoclonal antibody (an immune protein that binds to interleukin 6) or placebo (a substance that appears identical to the treatment and has no active ingredients). patients and study personnel did not know the identity of the administered treatments (double-blind study). increasing doses were given, based on safety data collected during the initial weeks of treatment. in part b, which was also double-blind, patients with sle were randomly assigned to receive multiple iv doses of the highest well-tolerated dose, as determined in part a, of cnto 136, or placebo.

Eligibility criteria:
inclusion criteria: * diagnosis of cutaneous lupus erythematosus (cle, including subacute cutaneous lupus erythematosus, discoid lupus erythematosus, or lupus erythematosus tumidus) or systemic lupus erythematosus (sle) * had a body weight less than or equal to 100 kg * patients in part a who were taking systemic medications for cle had to be on a stable dose for 4 weeks before the first study agent infusion * patients in part b taking systemic medications for sle had to be on a stable dose for at least 3 months before the first study agent infusion * given informed consent and willing and able to adhere to the study visit schedule and other protocol requirements; agreed to avoid alcohol intake; and took adequate measures to prevent pregnancy exclusion criteria: * significant history of or concurrent medical condition (other than lupus) * use of specific previous or concurrent medications or investigational therapies * known or suspected allergy to the study agent or it constituents, having recently donated blood, or having any significant laboratory test values requiring intervention * patients with sle in part b could not have active central nervous system lupus

Keywords: cutaneous lupus erythematosus systemic lupus erythematosus lupus erythematosus human anti-il 6 monoclonal antibody sirukumab