Kornimate/medical-research-clean huggingface dataset:
comparative effects of conscious abdominal contraction and closed kinetic chain exercises

Conditions: Subacromial Impingement

Summary: subacromial pain syndrome is a general term used to describe pain which originates from the shoulder and can spread towards the neck or down the arm. it's the most common reason for shoulder pain. the aim of study was to compare the effects of conscious abdominal contraction and closed kinetic chain exercises on the activation of peri-scapular muscles in badminton players with sub-acromial pain syndrome.

a randomized clinical trial was conducted at sir syed sports complex sargodha, through convenience sampling technique on 52 patients which was allocated using random sampling through computerized generated number into group a and group b. group a was treated with closed kinetic chain exercises. group b was treated with abdominal contraction exercises for periscapular activation. these exercises were done in 3 sets with 10 repetitions. there was 3 sessions per week. baseline measurement was taken on 1st day of evaluation and post treatment will be taken on 4th week. data was analyzed during spss software version 25. after assessing normality of data by shapiro-wilk test, it was decided either parametric or non-parametric test was used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * male badminton players * age 20 to 40 years * unilateral shoulder pain * pain with overhead activities * positive hawkins kennedy test * positive painful arc(60-120 degrees) * positive neer impingement test * positive external rotation test * numeric pain rating scale nprs value(3-7) exclusion criteria: * adhesive capsulitis * know shoulder instability * neck pain * radiating pain from shoulder to hand * receiving any intervention for shoulder injury. * previous history of 6 month shoulder trauma. * previous history of shoulder surgery. * taking any critical care medicine
minimally invasive or conventional edge-to-edge repair for severe mitral regurgitation due to bileaflet prolapse in barlow's disease: does the surgical approach have an impact on the long-term results?

Conditions: Barlow's Disease; Prolapse; Mitral

Summary: the study evaluates the long-term results of patients affected by bileaflet prolapse in barlow's disease, treated with edge-to-edge technique between 1997 and 2011.


Eligibility criteria:
inclusion criteria: patients treated for bileaflet prolapse in barlow's disease between 1997 and 2011 exclusion criteria: age inferior to 18 years
evaluate the performance of genetic amplification by polymerase chain reaction (pcr) and the "mannan antigenemia and antimannan antibodies couple as a means of diagnosis and a marker of follow-up in invasive candidiasis.

Conditions: Invasive Candidiasis; Treatment With Echinocandin

Summary: the study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management. these samples will make it possible to measure blood levels of certain markers specific to invasive candidiasis. pcr will be used to quantify fungal load precisely, that is to say the quantity of yeast present in the blood and to monitor this quantity over time. these samples will be transferred to a specialized unit and stored for a maximum of three years for use at the end of the study.


Eligibility criteria:
inclusion criteria: * patient informed about the study * patients aged at least 18 years admitted to a medical intensive care or general intensive care * patients with suspected invasive candidiasis - that is to say: * presenting persistent sepsis despite broad-spectrum antibiotherapy for at least 48 hours or targeted antibiotherapy for a documented bacterial infection (sepsis will be defined according to: * the usual sirs criteria, at least 2 of the following 4: temperature \> 38°c or \ 90/min, respiratory rate \> 20/min or blood pressure carbon dioxide (paco2 ) \ 12000/mm3 or \ 10% of immature forms. * persistent hemodynamic instability (impossibility to significantly diminish catecholamine requirement, need for rapid vascular resuscitation \> 1000 ml over the previous 24 hours) * candida score ≥ 3 with multifocal colonization * decision to initiate echinocandin therapy made by the clinician in charge of the patient exclusion criteria: * treatment with echinocandin \> 1 day in the week preceding inclusion * patients not covered by national health insurance * pregnant or breast-feeding women
computer vision syndrome prevalence among university students

Conditions: Computer Vision Syndrome

Summary: cvs-f3 questionnaire will be used as an instrument to survey cvs prevalence and severity among medical students

cvs-f3 is a valid questionnaire that includes 26 questions to be responded by the medical students to detect cvs complains and possible complications. the questionnaire includes questions regarding potential ocular, extra-ocular, musclo-skeletal and neuro-psychatric complains caused by cvs. complete statistical analysis of the survey data will be done using univariate and multivariate logistic and linear regression analysis.

Eligibility criteria:
inclusion criteria: * university students * studying medicine exclusion criteria: * ocular surgery * amblyopia * anisometropia * strabismus * dm * hypertension
open label extension study to investigate long term safety, tolerability and efficacy of pf-02545920 in subjects with huntington's disease who completed study a8241021

Conditions: Huntington's Disease

Summary: this study is a 12 month open label extension study of pf-02545920 20 mg dosed bid following study a8241021 in subjects with hd. primary endpoints will be to assess long-term safety and tolerability of 20 mg bid of pf-02545920. secondary endpoints will be the change from baseline in the total motor score (tms)assessment, and/ior the total maximum chorea (tmc) assessment of the unified huntington disease rating scale (uhdrs) after 6 and 12 months of treatment, and clinical global impression-improvement score after 6 and 12 months of treatment. subjects, who were assigned to the 20 mg pf-02545920 dose group in the preceding a8241021 study, will receive 20 mg pf-02545920 without any titration. all other subjects will be titrated to the 20 mg bid dose as follows: 5 mg bid for 7 days, 10 mg bid for 7 days, 15 mg bid for 7 days, then 20 mg bid for the remainder of the treatment phase. up to 260 subjects may take part in this open label extension


Eligibility criteria:
inclusion criteria: * subjects must have completed study a8241021 * diagnosis of hd, including ≥36 cag repeats. exclusion criteria: * significant neurological disorder other than huntington's disease. * wbc ≤ 3500/mm3 and/or anc ≤ 2000/mm3 and history of neutropenia or myeolo-proliferative disorders. * any drug related sae experienced during study a8241021 which were not approved as acceptable for enrollment in a8241022.

Keywords: huntington; chorea; total motor score; cag repeat: total functional capacity; motor cognitive and behavioral symptoms
a study on different treatments for knee osteoarthritis caused by damaged roots of the medial meniscus.

Conditions: Osteoarthritis; Meniscus Lesion

Summary: medial meniscus posterior root tears (mmprt) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining magnetic resonance imaging(mri) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. this is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of posterior root tear of the medial meniscus; 2. patients with k-l classification ≤ grade ii; 3. the age range of 50-65 years old; 4. international cartilage repair society (icrs) modified magnetic resonance imaging grading system ≤ grade 2; 5. international cartilage repair society (icrs) arthroscopic grading system ≤ grade 2; 6. knee joint mobility ≥90°; 7. inversion deformity ≤10°; 8. must be able to complete follow-up mri within 2 years after knee meniscus surgery; 9. must be able to complete clinical data; exclusion criteria: 1. can not participate in this study; 2. patients with concomitant meniscal injuries elsewhere; 3. knee joint infection disease; 4. osteoporosis disease; 5. patients with previous history of knee surgery; 6. knee joint instability disease; 7. severe koa disease; 8. can not cooperate with mri detection; 9. cannot tolerate the surgery; 10. those who cannot tolerate the arthroscopic knee surgery; 11. neuromuscular system pathology disease;

Keywords: posterior meniscus root lesion;osteoarthrotis
revitalize: rct to reduce fatigue in adults with ovarian cancer on parp inhibitors

Conditions: Ovarian Cancer; Advanced Ovarian Carcinoma; Fallopian Tube Carcinoma; Primary Peritoneal Cancer; PARP Inhibitor; Fatigue Related to Cancer Treatment; Fatigue in Cancer Survivors

Summary: the purpose of this study is to see whether a supportive intervention (revitalize) reduces fatigue and its impact on daily life and activities for participants with ovarian cancer taking parp inhibitors. the name of the study groups in this research study are: 1. revitalize 2. educational materials

this phase 3 randomized controlled trial will evaluate the effect of a brief, acceptance-based tele-health intervention (revitalize) vs. educational materials in participants with ovarian cancer who are taking poly-adp ribose polymerase (parp) inhibitors. participants will be randomized into one of two study groups: 1) revitalize or 2) educational materials. randomization means a participant is placed into a study group by chance. the research study procedures include screening for eligibility, using a wireless pill bottle, and completing questionnaires. participation in this research study is expected to last about 7 months. it is expected about 240 people will take part in this research study. the national cancer institute is supporting this research by providing funding.

Eligibility criteria:
inclusion criteria: * adult patients (age ≥ 18 years) with ovarian, fallopian tube, or primary peritoneal cancers (hereafter ovarian cancer) who have completed primary therapy (surgery and chemotherapy). * treated with a parp inhibitor as maintenance therapy for ≥2 months and plan to continue for at least 7 months. * english-speaking. * mean fatigue severity level ≥4 on the first three items of the fatigue symptom inventory. * ecog performance status of 0-2. * willing to use a wireless pill bottle for parp inhibitor medication. exclusion criteria: * untreated clinical condition or comorbid condition that pre-dates parp inhibitor use and could explain fatigue, as evaluated by their treating oncologist. * patients with severe psychiatric conditions (e.g. untreated trauma unrelated to cancer, high or imminent suicidality) as evaluated by their treating oncologist, which require more intensive psychiatric treatment than the study can provide. * patients with cognitive conditions (e.g. dementia), determined by their treating oncologist, such that they could not provide informed consent or complete the study procedures. * inability to complete the first questionnaire within one week of consent.

Keywords: ovarian cancer advanced ovarian carcinoma advanced ovarian cancer primary peritoneal cancer fallopian tube cancer fatigue related to cancer treatment fatigue in cancer survivors parp inhibitor
music against psychological pain in suicide

Conditions: Suicide, Attempted; Suicidal Ideation

Summary: this study compares the efficacy of music therapy associated with standard care versus the standard care alone on the psychological pain in suicidal patients.

music therapy consists of using the music care tool. each patient randomized in the music therapy arm should perform 4 music therapy sessions of 30 minutes on 48h. before and after each music therapy sessions, the psychological pain will be measured by the analogical visual scale. standard care consists of a medical and paramedical interview lasting 20-30 minutes. at the end of the interview, a drug treatment (bzd anxiolytic and/or hypnotic) is prescribed and the patient is hospitalized. during hospitalization, patient is regularly interviewed in order to evaluate his psychological status.

Eligibility criteria:
inclusion criteria: * patient with suicidal ideas, thoughts or surviving suicide attempt * patient whose emergency somatic management lasted less than 48h * patient who, according to the physician, is still in suicidal mood * patient admitted in the psychiatric hospitalization unit of the public mental health establishment * patient with voluntary admission and agrees to stay in hospital from 48h to 60h * patient able to write and read in french * patient affiliated to a social security scheme * patient who gives his informed consent before any procedure related to the study exclusion criteria: * patient with attempt suicide requiring a somatic care (intensive, surgery, gastric lavage...) * patient with medical history of audiogenic and/or musicogenic epilepsy * patient with major impairment of hearing function * patient unable to support the headhset earphone * patient with contra indication to bzd, hypnotics (zopiclone) or requiring more sedative and/or psychotic drugs * patient under guardianship or under judicial protection * patient hospitalized at the request of a third party or ex officio
to explore the related factors of cough after thoracoscopic pneumonectomy

Conditions: Cough

Summary: to explore the related factors of cough after uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. the incidence of cough can reach 25% ≤ 50%. cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old, male and female * uniport video-assisted thoracoscopic surgery * no cough symptoms within two weeks before operation * informed consent form was signed before operation exclusion criteria: * diabetes , heart, brain, liver and kidney diseases * chest radiographs / ct in recent months indicate pneumonia * pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection * distant metastasis patients * before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)

Keywords: postoperative cough multivariate analysis non-small cell lung cancer (nsclc) uniport video-assisted thoracoscopic surgery
create - children reading with electronic assistance to educate

Conditions: Vision, Low; Child; Adolescent Development

Summary: this pilot randomized controlled trial (rct) will test the methodology for a full rct of assistive technologies for children/young people with low vision/blindness. the investigators will recruit 40 students age 10-18 years in india and the uk, who will be randomised into two groups. apple ipads will be the active intervention; the control arm will be the local standard low-vision aid care. primary outcomes will be acceptance/usage and accessibility of the device and trial feasibility measures. exploratory outcomes will be validated measures of vision-related quality of life for children/young people as well as validated measures of reading and educational outcomes. in addition, the investigators will carry out semistructured interviews with the participants and their teachers, and attempt to evaluate cost-effectiveness.


Eligibility criteria:
inclusion criteria: inclusion criteria: * age 10-18 years * low vision, defined as "best corrected visual acuity (bcva) for distance between - less than 6/18 (0.48 logmar) and 3/60 (1.30 logmar) in the better eye" (who) ability to read printed material * no previous or current use of a tablet computer for educational purposes we will include students who have access to a tablet computer already, but only use it for recreational purposes. we will also include students who use a laptop. we will also include students who use or have previously used optical low-vision aids such as magnifiers, telescopes and cctv systems. exclusion criteria: * current or previous use of a tablet computer for educational purposes
oasis donor site wounds post-market study

Conditions: Surgical Wound; Wound; Wounds and Injuries; Wound Heal

Summary: the purpose of this study is to demonstrate the safety and performance of oasis extracellular matrix (ecm) when used as a treatment for donor site wounds in the united kingdom. oasis ecm is commercially available for the treatment of partial and full-thickness skin wounds, including chronic wounds, wounds from trauma, and wounds that occur during surgery, such as donor site wounds. the ability of the oasis ecm to promote the healing of donor site wounds will be evaluated in this study. about 40 patients (20 in each arm) over 16 years old will be involved in this study at one center in the united kingdom.


Eligibility criteria:
inclusion criteria: 1. has a split thickness skin graft (stsg) donor site wound no greater than 14 x 20 cm in size requiring placement of a covering material. 2. has at least 24 hours to consent to study participation. exclusion criteria: 1. age \< 16 years 2. patients who, in the opinion of the investigator, have co-morbidities that impair wound healing, such as: 1. chronic inflammatory skin condition 2. chronic liver failure 3. chronic renal failure 4. blood-borne viruses (hep b, hep c, hiv) 5. peripheral vascular disease 6. clinically significant anaemia 7. uncontrolled diabetes 3. need for use of the same harvest site (re-cropping) 4. history of radiation therapy to proposed donor site 5. chronic use of medications known to impair wound healing 6. chronic use of opioids or neuropathic pain agents 7. suspected cellulitis, osteomyelitis or septicaemia 8. patients undergoing haemodialysis 9. patients requiring spinal/regional block 10. patients on current anti-coagulant therapy 11. unable or unwilling to provide informed consent 12. unable or unwilling to comply with the study follow-up schedule, and procedures 13. simultaneously participating in another investigational drug or device study (patient must have completed the follow-up phase for the primary endpoint of any previous study at least 30 days prior to enrolment in this study) 14. allergy or hypersensitivity to materials that are porcine-based 15. cultural or religious objection to the use of pig or porcine products 16. known intolerance/allergy to standard wound care products 17. presence of a local infection at the donor site and/or systemic infection

Keywords: donor site wound
effects of hypoxic-hyperoxic preconditioning in cardio-surgical patients

Conditions: Myocardial Reperfusion Injury; Hypoxia; Hyperoxia; Coronary Artery Disease

Summary: coronary artery bypass grafting (cabg) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases. the heart is subjected to a long period of ischemia due to the occlusion of the aorta. the heavy burden of myocardial ischemia-reperfusion injury (iri) thus induces cardiomyocyte death, which can paradoxically reduce the beneficial effect of cabg. preconditioning by moderate hypoxia or hyperoxia serves as an effective drug-free method to increase the organism's resistance to negative effects, including iri.

it has been firmly established that the diminished oxygen delivery to the tissues in response to hypoxia is countered by a combination of the increased regional blood flow and the enhanced functional capillary density in the microcirculation. in experimental studies, exposure to hyperoxia for a limited time before ischemia induces a low-grade systemic oxidative stress evokes a preconditioning-like effect on the myocardium and reduces the infarction area by 20%, and the number of arrhythmias after ischemia-reperfusion. one hundred twenty patients were randomly assigned into two equal groups: hypoxic-hyperoxic preconditioning before the surgery (hhp group) and the control group (without preconditioning). safety control of the preconditioning procedure included ecg monitoring, invasive blood pressure, cardiac output, pulse oximetry, capnography, cerebral oximetry, measurement of anaerobic threshold; acid-base status and metabolic state of arterial and venous blood were assessed once every 10 min during the preconditioning procedure; oxygen balance parameters were calculated. seventy-two hours before the surgery, an anaerobic threshold was determined to establish a safe oxygen concentration in the respiratory gas mixture during the hypoxic preconditioning phase from 10 to 14%, followed by 75-80% oxygen concentration during the hyperoxic phase. the hypoxic-hyperoxic preconditioning with individual parameters selection based on the anaerobic threshold in patients with coronary artery diseases before the main stage of cardiac surgery with a cardiopulmonary bypass should reduce the duration of mechanical ventilation, catecholamine support, and frequency of perioperative complications.

Eligibility criteria:
inclusion criteria: * the need for coronary artery bypass grafting (cabg) exclusion criteria: * age over 75 years * emergency surgery * diabetes mellitus * exacerbation of a chronic disease 1 week before surgery * any oncological disease at the time of the examination

Keywords: myocardial protection preconditioning hypoxia hyperoxia ischemia-reperfusion injury cardiopulmonary bypass oxygen transport