Kornimate/medical-research-clean huggingface dataset:
the efficacy of sglt-2 inhibitor in patients with cad and dm undergoing pci.

Conditions: Coronary Artery Disease; Diabete Mellitus

Summary: the study is to compare the effects of sglt-2 inhibitors and other oral hypoglycemic agents in patients with coronary heart disease and diabetes mellitus undergoing percutaneous coronary intervention.

this is a single center, observational study designed to evaluate the efficacy of sglt-2 inhibitors and other oral hypoglycemic agents in patients with coronary heart disease and diabetes mellitus who underwent percutaneous coronary intervention (pci). 1424 subjects will be enrolled. all patients were divided into the sglt-2 inhibitors group and other oral hypoglycemic agents group according to whether they were discharged with sglt-2 inhibitors or not. the primary endpoint is adverse cardiovascular and cerebrovascular events (macce), composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke and unplanned coronary revascularization at 12 months after the index pci. the key secondary endpoints are changes in insulin resistance index and platelet reactivity at 3 months and change in glucose and lipid metabolism at 12 months after the index pci.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years 2. patients with coronary heart disease and diabetes mellitus who underwent percutaneous coronary intervention. 3. patients were provided informed consent before the procedure. exclusion criteria: 1. history of diabetic ketoacidosis, type 1 diabetes, pancreas or beta-cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy. 2. history of one or more severe hypoglycemic episode within 6 months before screening 3. ongoing, inadequately controlled thyroid disorder. 4. history of hepatitis b surface antigen or hepatitis c antibody positive 5. any history of or planned bariatric surgery. 6. current use of a corticosteroid medication or immunosuppressive agent, or likely to require treatment with a corticosteroid medication.

Keywords: coronary artery disease diabetes mellitus percutaneous coronary intervention sglt-2 inhibitor insulin resistance platelet reactivity
the development of a novel biomarker for early identification of the individual's state of tolerance to heat

Conditions: Heat Stroke; Healthy

Summary: today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. we hypothesize that oxidative stress (os) and the formation of reactive oxygen and nitrogen species (ros, rns), which are part of the underling pathophysiology related to hyperthermia, can be used to identify tolerance/intolerance to heat. the aim of the present project is to develop a simple assay, based on specific designed sensitive biomarkers of os that can be detected in a small blood sample, and to possibly correlate each individual's state of tolerance to heat to the level of os. these biomarkers specially designed and synthesized to form a novel probe (not present as such in biological organs). the method will be based on the incubation of the suggested biomarkers with the patient's blood sample and the measurement of the level and type of oxidative alteration of the markers. for this goal, post heat stroke patients, with different levels of tolerance to heat and subjects during a process of acclimation to heat will be studied. such a method will add to our ability to better determine the level of tolerance to heat and not rely only on the measurements of temperature and heart rate during an exercise-heat stress.


Eligibility criteria:
inclusion criteria: for study group: post heat stroke subjects. for control group: healthy subjects matched by age to study group exclusion criteria: for control group: any prior heat illness, diabetes, heart failure, high blood pressure (sbp \>140mmhg), any febrile illness within the last two weeks prior to testing. for study group: diabetes, heart failure, high blood pressure (sbp \>140mmhg), any febrile illness within the last two weeks prior to testing

Keywords: tolerance to heat
evaluation of aqueous humor of levofloxacin-dexamethasone eye drops and of its components in patients undergoing cataract surgery

Conditions: Cataract

Summary: the purpose of this study is to evaluate the penetration of levofloxacin and dexamethasone 21-phosphate into the aqueous humour after ocular administration in combination or as single active ingredients.

in most cases, postoperative care after cataract surgery consists of antiinflammatory and antibacterial drug therapy. the use of an ophthalmic solution containing the combination of a steroid and an antibiotic is routinely used in clinical practice; however, treatment duration could favour the emergence of antibiotic resistance. the study treatment associating a broad-spectrum antibiotic with a highly effective corticosteroid that can be used for a short period of time (one week) is therefore of considerable interest. the aim of this study is to measure the concentrations of levofloxacin and dexamethasone in the aqueous humour after topical application of the combined ophthalmic solution and its single components.

Eligibility criteria:
inclusion criteria: 1. written informed consent 2. male or female patients, aged ≥40 years 3. patient undergoing phacoemulsification 4. corneal thickness between 450 μm and 600 μm as measured by means of pachymetry 5. corneal integrity confirmed by means of fluorescein test 6. adequate pupil dilation assessed at screening 7. female patients of childbearing potential must have a negative pregnancy test 8. ability to fully understand all study procedures exclusion criteria: 1. corneal epithelium integrity not confirmed by fluorescein test 2. history of corneal disease or dystrophy 3. history of ocular trauma with corneal damage 4. history of acute ocular inflammation (including uveitis) in the 6 months prior to screening 5. previous ocular surgery (including laser treatment) 6. glaucoma 7. treatment with an ophthalmic investigational drug in the 3 months prior to screening 8. treatment with any topical ocular drug within 12 hours before start of cataract surgery other than study drugs and instillation of topical anaesthetic within 10 minutes before start of surgery 9. treatment with any topical steroid or antibiotic drug in the 7 days prior to cataract surgery 10. treatment with any systemic steroid or antibiotic drug in the 7 days prior to cataract surgery 11. known hypersensitivity to levofloxacin, other fluoroquinolones or dexamethasone 12. pregnant or lactating women 13. patients who have received any investigational drug during the preceding 30 days or 5 times the plasma half-life, or who have previously participated in this trial
functional organization of the superior temporal gyrus for speech perception

Conditions: Epilepsy; Brain Tumor; Speech

Summary: the basic mechanisms underlying comprehension of spoken language are still largely unknown. over the past decade, the study team has gained new insights to how the human brain extracts the most fundamental linguistic elements (consonants and vowels) from a complex and highly variable acoustic signal. however, the next set of questions await pertaining to the sequencing of those auditory elements and how they are integrated with other features, such as, the amplitude envelope of speech. further investigation of the cortical representation of speech sounds can likely shed light on these fundamental questions. previous research has implicated the superior temporal cortex in the processing of speech sounds, but little is known about how these sounds are linked together into the perceptual experience of words and continuous speech. the overall goal is to determine how the brain extracts linguistic elements from a complex acoustic speech signal towards better understanding and remediating human language disorders.

intracranial high-density electrodes make it possible to record neural activity directly from the brain surface with unparalleled spatial and temporal resolution to unravel both local and population encoding of speech sounds. this study proposes to assess speech perception in patients who are undergoing surgery for seizure localization or awake intraoperative brain mapping. electrode placement is based on the clinical needs of each patient. the research study team will examine the mechanisms of phonetic encoding to reveal both the organization of auditory speech feature selectivity and the distributed population-level processing that give rise to the emergent properties of spoken language perception. the aims of this study seeks to determine the cortical encoding of phonological sequencing (aim 1), representation of amplitude landmark coding in speech (aim 2), and the shared and distinct mechanisms for speech and music melody encoding (aim 3). together, these aims will advance our understanding of speech encoding in the human brain beyond consonants and vowels, addressing questions pertaining to sequencing, amplitude coding, and auditory specialization. these results should heavily impact current theories of speech processing and, therefore, will have significant implications for understanding and remediating human language disorders.

Eligibility criteria:
inclusion criteria: * participants with epilepsy or brain tumors at ucsf undergoing surgical electrode implantation for seizure localization or awake intraoperative brain mapping for resection of brain tumors or epilepsy and * participants with electrodes implanted in at least two regions of interest who are willing and able to cooperate with study tasks. exclusion criteria: * participants who lack capacity or decline to provide informed consent, * participants who have significant cerebral lesions or * participants with cognitive deficits that preclude reliable completion of study tasks.
the morphometric parameters of shoulder and supraspinatus tendinosis

Conditions: Shoulder Pain; Tendinosis

Summary: supraspinatus tendinosis one of the most common pathologies of the musculoskeletal system.the aim of this study to investigate the relationship between supraspinatus tendinosis and shoulder morphology with magnetic resonance imaging (mri).

supraspinatus tendinosis one of the most common pathologies of the musculoskeletal system. it affects 15-50% of the population and its prevalence increases with age. it can lead to useful disability as well as ease of life. weight, old age and traumas as recurrent risk for ss tendosis. in the literature, there are a large number of small and small numbers among the biology of supraspinologicus tears .the aim of this study to investigate the relationship between supraspinatus tendinosis and shoulder morphology with magnetic resonance imaging (mri).

Eligibility criteria:
inclusion criteria: * patients with shoulder pain or healthy controls exclusion criteria: * patients with a history of shoulder surgery or trauma, inflammation of the shoulder joint, inflammatory arthritis, space-occupying mass lesions, rupture of the supraspinatus tendon or calcific tendinitis were excluded from the study.
assessing people's hospital outpatient appointment preferences in the united kingdom

Conditions: Hospital Outpatient Clinics; Chronic Disease

Summary: the sustainability of the united kingdom's national health service's (nhs) is threatened immediately by covid-19 and continually by an increasing prevalence of long-conditions that cannot be cured but can be maintained. shifting traditional face-to-face outpatient appointments to remote video consultations may help the nhs continue to serve patients efficiently. while much research has examined healthcare providers' attitudes and beliefs about remote video consultations, less has attempted to understand how nhs service providers should invite patients to attend them. the present study examines how the framing of an invitation to attend a hospital outpatient appointment by video influences the proportion of people who agree to attend by video. it also explores some of the barriers and facilitators people may experience to attending appointments by video across diagnostic complexities and age groups. the results of this study should help hospitals better present patients with the option to attend video consultations where appropriate, and provide support to mitigate common barriers to people's willingness to give video consultations a go.


Eligibility criteria:
inclusion criteria: all participants will: * be 18 years old or older; * be resident in the united kingdom; and * indicate having been diagnosed with a chronic diseases such as diabetes, heart disease, stroke etc. exclusion criteria: * be less than 18 years old; * not be resident in the united kingdom; and * not indicate having been diagnosed with a chronic diseases such as diabetes, heart disease, stroke etc.
study evaluating the effects of multiple oral doses of erb-041 on cardiac repolarization in healthy subjects

Conditions: Healthy; Long QT Syndrome

Summary: to assess the effect of erb-041 after multiple oral doses on cardiac repolarization as assessed by the qtc interval.


Eligibility criteria:
inclusion criteria: * healthy as determined by the investigator on the basis of medical history, physical examination, clinical laboratory test results, vital signs, and ecg. * nonsmoker or smoker of fewer than 10 cigarettes (half a pack) per day as determined by history. exclusion criteria: * a family history of long qt syndrome and/or cardiac death. * any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematological, neurological, or psychiatric disease.

Keywords: healthy cardiac pharmacokinetics
effect of anti-inflammatory and anti-microbial co-supplementations in traumatic icu patients at high risk of sepsis

Conditions: Major Trauma; Sepsis

Summary: the occurrence of sepsis in trauma patients is a very serious complication. identifying trauma patients at high risk of sepsis was not revealed in the latest surviving sepsis campaign in 2016. several biomarkers have been proposed for early prediction of sepsis in trauma patients as leukocyte anti sedimentation rate (lar) and the proinflammatory cytokine monocyte chemo attractant protein-1 (mcp-1). sepsis prophylaxis before occurrence of multi-organ failure still represents a major challenge. vitamin d and probiotics have antimicrobial, anti-inflammatory and gut microbiota immune modulatory properties.little is known about the effect of vitamin d and probiotics co-supplementation on the inflammatory response in trauma patients at high risk of sepsis. another promising strategy is the use of vitamin c in addition to thiamine. trauma is associated with increased oxidative stress and vitamin c deficiency. high dose vitamin c is required to restore oxidant-antioxidant balance. vitamin c and thiamine have shown promising results in treatment of sepsis. vitamin c possesses anti-inflammatory, endothelial protective and anti-microbial effects. thiamine is the precursor of thiamine pyrophosphate (tpp), a key enzyme in krebs cycle.

this study will investigate effect of vitamin d and probiotics versus vitamin c and thiamine on inflammatory response (represented by change in mcp-1 level), sequential organ failure assessment (sofa) score and acute physiology and chronic health evaluation ii (apache ii) in trauma patients at high risk of sepsis. secondary goal is to assess if the predictive ability of mcp-1 plus lar to determine high risk of sepsis in major trauma intensive care patients and if there is correlation between lar and mcp-1.

Eligibility criteria:
inclusion criteria: * adult trauma patients admitted to icu within 24 hours from trauma onset with injury severity score (iss) ≥ 16 will be recruited after obtaining informed consent exclusion criteria: * • patients admitted to icu after time exceeding 24 hours from trauma onset. * patients whose age is less than 18 years. * pregnant female. * breast feeding women. * arrest within 24 hours of admission. * immune deficiency or administration of immune suppressant drugs. * serum calcium greater than or equal to 10 mg/dl or phosphate greater than or equal 6 mg/dl. * history of primary parathyroid disease. * metabolic bone disease. * sarcoidosis. * end stage renal disease. * receiving intermittent renal replacement therapy (rrt). * failure of enteral feeding or any contraindication to enteral administration. * obesity , body mass index (bmi \> 35 kg/m2) * known contraindication to vitamin c or thiamine (oxalate nephropathy or known glucose-6-phosphate dehydrogenase deficiency)
ppcm observational study (peripartum cardiomyopathy)

Conditions: Peripartum Cardiomyopathy; Cardiogenic Shock

Summary: the purpose of this study is to examine the clinical treatment of patients diagnosed with peripartum cardiomyopathy complicated by cardiogenic shock.

this single-site, virtual, longitudinal, observational study will investigate two cohorts (study groups) by enrolling a total of ten participants, five in each cohort. the two cohorts include individuals who received mechanical circulatory support (specifically the impella® device) compared to individuals who did not receive mechanical circulatory support for treatment of their ppcm complicated by cardiogenic shock index event. the duration of enrollment for each participant is about 5 months. it is anticipated that the trial will be complete in 12 months. participant engagement to the study will be self-initiated. under the guidance and support of medical college of wisconsin research coordinator, participants will directly access the study redcaptm database for enrollment and follow-up data entry for this study. the research coordinator will obtain and abstract participant medical records documenting the event.

Eligibility criteria:
inclusion criteria: females: * age ≥ 18 years old at the time of entry into the study * who have capacity to provide consent for study participation * with self-reported ppcm complicated by cardiogenic shock * individuals should have us citizenship * index event occurring within the continental united states. exclusion criteria: * lack of medical records supporting pregnancy, peripartum cardiomyopathy or cardiogenic shock by study definition * inability of participant to provide informed consent
biomarkers guided stopping nas treatment

Conditions: Chronic Hepatitis b

Summary: the primary objective of this study is to evaluate hepatitis b surface antigen (hbsag) loss in subjects who stop nucles(t)ide analogues (nas) (stop arm) compared to subjects who continue (continue arm) only subjects who already are on treatment with etv, tdf or taf monotherapy, and have achieved sustained virologic suppression (\<20 iu/ml), hbeag negativity, normal alt for more than 1 year (pretreatment hbeag + pts) or 3 years (pretreatment hbeag - pts), plus qhbsag \<200 iu/ml, and hbv rna or hbcrag negativity will be included in this study. one treatment arm will stop the nas therapy while the other treatment arm will continue the nas therapy. participants in the stop arm will be monitored very closely with special focus on clinical relapse. if any participant in the stop nas arm exceeds one or more predefined limits for such flares or relapses, nas treatment will be reinstituted.


Eligibility criteria:
key inclusion criteria: * 18-65 years of old, male or female * chronic hepatitis b patients * received continuous etv, tdf or taf therapy for at least 1 year prior to screening and at screening * for patients with hepatitis b e antigen (hbeag)-positive at the beginning of nas therapy, documented hepatitis b virus \<20 iu/ml, hbeag seroconversion and alt normalization for at least 1 year prior to screening and at screening * for patients with hbeag-negative at the beginning of nas therapy, documented hepatitis b virus \<20 iu/ml, and alt normalization for at least 3 year prior to screening and at screening * \<= 9 kpa on fibroscan assessment * qhbsag \<200 iu/ml within 24 weeks prior to screening * hbv rna or hbcrag negativity within 24 weeks prior to screening key exclusion criteria: * experience of ifn treatment within 1 year prior to screening * known cirrhosis * history of decompensated liver disease * history of clinical hepatic decompensation in the judgement of the investigator * evidence of hepatocellular carcinoma * serological evidence of coinfection with human immunodeficiency virus (hiv), hepatitis c virus, or hepatitis d infection * known hypersensitivity to tdf, its metabolites, or formulation excipients * history of malignant disease * lactating females * females wishing to became pregnant during the duration of the study * subjects participating in another clinical trial
study on efficacy and safety of human albumin in burn shock recovery

Conditions: Burns Shock

Summary: to explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.

a retrospective case-control study was conducted. patients who admitted to the burn ward and needed fluid resuscitation during the period of january 2011 to december 2018 in our unit were identified. patients were divided into two groups according to the severity of burns, the patients with a 20%\ 50% constituted the severest burn group, and then the patients who used albumin for resuscitation constituted the albumin group, the patients who did not use albumin constituted the control group. the primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * tbsa≥ 20% （tbsa，the total burn area.） * admitted to hospital within 24 hours after injury. exclusion criteria: * stb ≥ 33 μ mol/l * cr ≥ 171 μ * urine output l\< 500 ml / 24 h * pregnant and lactating women * severe combined injury * glucocorticoids users * immunosuppressants users * patients survived less than 48 hours

Keywords: burns; shock; recovery; human albumin; effect
low vs medium pressure pneumoperitoneum

Conditions: Appendicitis Acute

Summary: the purpose of this study is to asses whether the pressure used for the pneumoperitoneum during laparoscopic surgery in children affects their postoperative pain levels.


Eligibility criteria:
inclusion criteria: * prepped and consented for diagnostic laparoscopy for likely acute appendicitis * 5 years or older * 15 kg or more * parents/legal custodian give consent, patient shows no signs of unwillingness to participate * patient is hemodynamically stable exclusion criteria: * clinical signs of four quadrant peritonitis as a clinical sign of perforated appendicitis * suspected perityphlitic abscess on preoperative ultrasound * preexisting conditions making postoperative assessment of extent of pain and its localization very difficult or impossible, e.g. conditions that are associated with pronounced developmental delays or with communication difficulties * parents have inadequate knowledge of german language to understand informed consent * child has inadequate knowledge of german language to allow elicitation of pain scores

Keywords: pneumoperitoneum pressure pain