Kornimate/medical-research-clean huggingface dataset:
study of poetic dignity therapy for sexual and gender minority patients with cancer

Conditions: End of Life

Summary: the purpose of this study is to find out if dignity therapy is practical and works well for sexual and gender minority (sgm) patients in msk. sgm includes, but is not limited to, people who identify as lesbian, gay, bisexual, transgender, and/or queer/questioning (lgbtq+). dignity therapy is a type of psychotherapy where the clinician asks the patient questions to allow the patient to express their individual life story and ultimately be able to create a legacy document of their experiences that can be shared with their loved ones.


Eligibility criteria:
inclusion criteria: * sgm (as per self-report) palliative care patients identified through memorial sloan kettering cancer center's palliative care team and primary solid tumor oncology clinics. * age 18 and older (as per self-report/ehr) * english-speaking as per the english language assessment items below and wil ing to receive the intervention in english. o what is the participant's preferred language? * (specify lang)___________________________ * how well does the participant speak english? * very well (participant is eligible) * well (participant is eligible) * not well (participant is not eligible) * not at all (participant is not eligible) exclusion criteria: * delirium/ altered mental status prohibitive of providing consent.

Keywords: dignity therapy (dt) end of life (eol)
effects of muscle strengthening and fatigue on activities in cortex and muscle

Conditions: Healthy Adults

Summary: we will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction. healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%mvc, 180°/s, eccentric).maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity

cross education (ce) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. ce has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. although ce has several potential clinical application, the precise physiological mechanisms underlying ce remains unknown. previous studies reported that ce may involve bilateral cortical activity in both contralateral primary motor cortex (cm1), and ipsilateral primary motor cortex (im1).in addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but ce immediate change of functional connectivity in cortical network remains unknown. the purposes of this study are to investigate the immediate effect of ce training of biceps brachii (1) immediate change of functional connectivity in cortical network; (2) immediate change of functional connectivity in cortex and target muscle; (3) explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. we hypothesize that (1) bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) cross education would immediately enhance functional connectivity between cortex and target muscle; (3) cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.

Eligibility criteria:
inclusion criteria: 1. healthy adults who are 20-40 years old exclusion criteria: 1. upper extremity (ue) pain or discomfort 2. medical condition that substantially influenced their ue strength 3. experience of ue surgery 4. paresthesia in ue 5. open wound on ue

Keywords: cross education, functional connectivity
study of a home delivered meal program on obese elderly african american subjects with type 2 diabetes mellitus (dm)

Conditions: Obesity; Diabetes

Summary: the purpose of this study is to assess the impact of home-delivered medical nutrition therapy on clinical outcomes for persons with diabetes. the primary outcomes of this studies include a1c (a1c), blood glucose, blood pressure, body mass index, lipid levels and other measures of disease progression and management as well as costs of medical care provided throughout the intervention period.

data collected as a result of this project will be evaluated in aggregate to demonstrate the potential impacts on health and medical costs available through this type of intervention, with long-term goals of reducing disability and deaths due to chronic disease.

Eligibility criteria:
inclusion criteria: 1. african-american subjects 2. males or females 65 - 85 years of age 3. body mass index (bmi) equal to or greater than 30 kg/m2 4. fasting blood glucose less than 300 mg/dl and hba1c less than 9.0% 5. ability to understand and be willing to adhere to the study protocol 6. a known history of type 2 diabetes mellitus greater than 3 months, receiving either diet alone or oral antidiabetic agents (sulfonylureas, metformin, thiazolidinediones). exclusion criteria: 1. subjects with a history of diabetic ketoacidosis and hyperosmolar hyperglycemic state. 2. patients with clinically relevant hepatic disease or impaired renal function, as shown by a serum creatinine greater than 3.0 mg/dl. 3. mental condition rendering the subject unable to understand the scope of the study.

Keywords: obesity diabetes endothelial function insulin sensitivity
different lipid emulsions in acute lung injury patients

Conditions: Parenteral Nutrition

Summary: aim is to investigate the influence of an early supply of parenteral nutrition including a fish oil containing lipid emulsion on the course of acute lung injury in the intensive care unit. in comparison, a standard parenteral nutrition with a soybean oil based emulsion will be used. data obtained in this trial may provide evidence for a beneficial effect of fish oil derived omega-3 fatty acids in parenteral nutrition regarding their influence on acute lung injury.


Eligibility criteria:
inclusion: * acute lung injury as a result of proven pneumonia (x-ray) or witnessed aspiration * oxygenation factor ≤ 300 * \<= 72 hours since intubation or non-invasive ventilatory support by mask at screening * expected need for parenteral nutrition for at least 5 days * male or female ≥ 18 years of age exclusion: * exclusion of pregnancy in women with child-bearing potential * cardiogenic pulmonary oedema * previous (\ 0.1 mg/kg/d prednisolon-equivalent or other immune suppressive treatment * active or previous (\< 1 year) treatment for solid or haematologic malignancy * serum triglycerides \> 300 mg/dl at screening * alterations of coagulation (thrombocytes \ 60 sec, inr ≥ 2.5 without therapeutic intervention * autoimmune disease or hiv (according to medical history) * known or suspected drug abuse * general contraindications to infusion therapy :
mito-2: a study comparing 2 chemotherapy regimens (carboplatin/liposomal doxorubicin vs carboplatin/paclitaxel) in patients with ovarian cancer

Conditions: Ovarian Cancer

Summary: the purpose of this study is to compare the effectiveness (progression free survival) of the experimental combination of carboplatin + liposomal doxorubicin with the standard combination of carboplatin + paclitaxel in first line treatment of patients with ovarian cancer. secondary objectives are to evaluate overall survival, quality of life, objective response rate, and toxicity.

ovarian cancer is the second most frequent and the most deadly gynaecologic cancer. the high mortality rate is due to the late diagnosis of this malignancy that often develops without symptoms, as well as to limited results in treatment of the disease. patients may respond well initially to chemotherapy, but the vast majority of patients will experience a progression of the disease. the poor long term results in the standard treatment available today for first-line chemotherapy of ovarian cancer make research into new, more beneficial treatment strategies necessary. the proven efficacy of liposomal doxorubicin in second line treatment, where it is the first drug to have shown some significant benefit in terms of survival, and the possibility of easily combining it with full doses and normal use of carboplatin, encourages the testing of the effectiveness of the combination of carboplatin and liposomal doxorubicin in first line treatment. patients enrolled into this study will be randomly assigned to one of two treatment groups: · standard therapy consisting of 6 cycles of chemotherapy: * carboplatin auc 5 given intravenously on day 1 every 3 weeks and * paclitaxel 175 mg/m2 given intravenously on day 1 every 3 weeks or · experimental therapy consisting of 6 cycles of chemotherapy: * carboplatin auc 5 given intravenously on day 1 every 3 weeks and * liposomal doxorubicin 30 mg/m2 given intravenously on day 1 every 3 weeks

Eligibility criteria:
inclusion criteria: * cytologic / histologic diagnosis of stage ic-iv ovarian cancer * indication for chemotherapy treatment * age 75 years or less * life expectancy of at least 3 months exclusion criteria: * previous or concomitant malignant neoplasia (not including basocellular or spinocellular skin carcinoma or in-situ carcinoma of the uterine cervix, provided they are being adequately treated) * performance status (ecog) \> 2 * previous chemotherapy treatment * heart disease (heart failure, myocardial heart attack within 6 months prior to randomization, atrioventricular block of any degree, serious arrhythmia) * leukocytes \< 4000/mm3, neutrophils \< 2000/mm3, platelets \< 100000/mm3 * impaired renal function (creatinine \> 1.25 times the upper normal limit) or liver function (sgot or sgpt \> 1.25 times the upper normal limit) * present or suspected hemorrhagic syndromes * uncooperative and/or unreliable patients * patient's inability to access the center * refusal of informed consent

Keywords: ovarian cancer chemotherapy first-line
feeding the preterm gut microbiota - impact of infant-feeding on preterm gut microbiota development

Conditions: Very Preterm Infants

Summary: preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse. several factors may influence infants' microbiota such as mother's diet, mode of delivery, antibiotic exposure and type of feeding. the main goal of this observational study is to evaluate the impact of different types of feeding (breast milk, donor human milk and preterm formulas) on the intestinal microbiota of preterm infants hospitalized in the neonatal intensive care unit (nicu) of maternidade alfredo da costa (mac). furthermore, the influence of mode of delivery and the mother's diet, among others factors, on vertical microbiota transmission will be evaluated. after delivery, mothers will be asked to collect their own fecal samples and will be invited to complete a semi-quantitative food frequency questionnaire. stool samples will be collected from premature infants every 7 days. dna will be extracted from fecal samples and different bacterial genus and species will be analyzed.

meconium and the additional 3 fecal samples will be collected from preterm infants by the nursing team of mac neonatology unit. fecal samples will be collected every 7 days, during 21 days, from diapers into sterile tubes. mothers will be asked to collect their own fecal samples with an appropriate stool collection kit (easysampler®) and will be invited to complete a semi-quantitative food frequency questionnaire, previously validated for the portuguese population. infant-feeding profile (breast milk, donor human milk or formula) of preterm infants will be recorded every day to select the most representative (\>50 %) type of infant-feeding received during the 7 days prior to each fecal sample collection. additionally, detailed clinical data will be collected during the preterm infant enrollment in the study. personal clinical data includes sociodemographic information and clinical intrapartum and postpartum outcomes, such as newborn's weight, days of antibiotic exposure, number of total days of hospitalization and others outcomes related to the preterm clinical evolution.

Eligibility criteria:
inclusion criteria: * to be eligible for enrolment, preterm infants must have been admitted to the nicu in less than 24 hours of life, have been born with less than 32 weeks with absence of malformations or metabolic diseases. exclusion criteria: * non applicable

Keywords: intestinal microbiota preterm infants breast milk donor human milk formula
predictive clinical and biological parameters in acute leukemia, myelodysplastic syndromes and myeloproliferative disorders-hemato-bio-ipc-2013-015

Conditions: Acute Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders

Summary: hemato-bio-ipc-2013-015 is a monocenter prospective longitudinal study. our aim is to define predictive clinical and biological factors in acute leukemia, myelodysplastic syndromes and myeloproliferative disorders by using genomics, genetics and epigenetics, in vitro and in vivo drug sensitivity studies,and translational immonulogy and immunomonitoring studies. hemato-bio primary outcome measure is to identify molecular, genomic and epigenetic, pharmacologic and immunophenotypic alteration in acute leukemia, myelodysplastic syndromes and myeloproliferative disorders by collecting, at diagnosis and/or complete remission and/or relapse: * tumor samples: marrow aspiration, blood sampling. * non-tumor samples: skin biopsy, buccal swab . from 650 patients treated at our cancer center.


Eligibility criteria:
inclusion criteria: * acute leukemia, myelodysplastic syndrome or myeloproliferative disease * age \> 18 * affiliated to the french social security systm * signed informed consent exclusion criteria: * emergency * patients deprived of liberty or placed under the authority of a tutor
the value of end-tidal capnography in gastrointestinal bleeding

Conditions: Gastro Intestinal Bleeding

Summary: gastrointestinal bleeding is a condition that frequently presents to emergency departments and can be fatal if diagnosis and treatment are delayed. the working mechanism of end tidal capnography is simply to detect the respiratory carbon dioxide level. in our study, the investigators aimed to determine the severity of gastrointestinal bleeding by using the glaskow blachford score and aims65 score in cases presenting with gastrointestinal bleeding, to determine the end tidal carbon dioxide value by capnography in these cases and to determine its effectiveness in evaluating mortality and morbidity in gastrointestinal bleeding.

gastrointestinal (gi) bleeding is a condition that frequently presents to emergency departments and has a mortal course in case of delayed diagnosis and treatment. upper gi bleeding accounts for 5% of emergency department admissions. mortality rates vary between 2% and 15%. mostly, gi bleeding stops spontaneously and does not require endoscopic intervention, blood transfusion or surgery. however, among patients with life-threatening bleeding, timely intervention is very important. for this purpose, there are widely used and validated risk stratification tools such as the glasgow blatchford score (gbs) and the aims65 score. capnography involves the noninvasive measurement of co2 partial pressure during the respiratory cycle. it provides information on ventilation (efficiency of carbon dioxide elimination), perfusion (vascular co2 transport) and metabolism (co2 production through cellular metabolism). the principle of end-tidal capnography (etco2) is to detect the level of carbon dioxide in the expiratory breath.etco2 waveform changes provide information to physicians in various situations such as assessment of disease severity, cardiac arrest (quality of compression, return of spontaneous circulation, endotracheal tube placement, prognosis) procedural sedation and prediction of critical illness. in our study, the investigators aimed to determine the relationship of etco2 value with gbs and aims65 scores and its effectiveness on the evaluation of morbidity and mortality in patients admitted to the emergency department with gi bleeding.

Eligibility criteria:
inclusion criteria: * patients presenting to the emergency department with symptoms and signs of gastrointestinal bleeding (hematochezia, melena, hematemesis). * patients with a presumptive diagnosis of gastrointestinal bleeding confirmed by endoscopy and colonoscopy. * patients who consent to participate in the study. * patients aged 18 and older. exclusion criteria: * patients without symptoms and signs of gastrointestinal bleeding. * patients with a presumptive diagnosis of gastrointestinal bleeding ruled out by endoscopy and colonoscopy. * patients with respiratory pathologies that increase co2 levels (such as asthma, copd, pneumonia, etc.). * patients referred from external centers and underwent ert replacement. * patients with heart failure. * patients who refuse to participate in the study.
study of mitomycin c and nasal splint to treat nasal synechiae

Conditions: Nasal Synechiae; Adhesions of Nasal Cavity; Nasal Adhesions; Tissue Adhesions

Summary: this study evaluates whether mitomycin c is an effective alternative to septal splints in the treatment of nasal synechiae.

nasal synechiae is an important cause for the failure of many a nasal surgery. septal splints have been widely used for the treatment of nasal synechiae, but are associated significant morbidity until removal. to the best of our knowledge there are no studies in literature comparing mitomycin c with septal splints as an atraumatic alternative in the treatment of nasal synechiae. this is a preliminary study taken up to evaluate the therapeutic efficacy of mitomycin c in the treatment of nasal synechiae.

Eligibility criteria:
inclusion criteria: * patients with nasal mucosal synechiae due to surgical or non-surgical trauma exclusion criteria: * patients with nasal vestibular stenosis * patients with nasal synechiae due to diseases like hansen's disease, syphilis, rhinoscleroma, atrophic rhinitis etc.

Keywords: nasal adhesions nasal synechiae mitomycin mitomycin c teflon splints septal splints
effectiveness of infiltration with resin in treatment of mih incisors in children showing opacities

Conditions: Children, Adult; Molar Incisor Hypomineralization; Dental Diseases; Opacity; Anterior Teeth

Summary: enamel development defects are the result of a set of environmental, systemic and genetic causal agents that reveal a multifactorial etiology model, which in anterior teeth produces a serious aesthetic problem, converted into a problem of visual perception. in hypomineralized enamel, light rays encounter multiple interfaces between organic and mineral fluids, with different refractive indices. at each interface, the light is deflected and reflected, producing an overexposed "optical labyrinth" that is perceived as a yellow, white, or brown stain. the term "infiltration" has been modified and developed commercially in germany for the treatment of non-cavitated caries on smooth and proximal surfaces, in which the porosities of the enamel lesion are infiltrated with a low-viscosity resin, thus creating a barrier of diffusion, without the need for any type of additional material on the tooth surface. an added positive effect of infiltration with the queens is that the enamel lesions lose their whitish appearance when the microporosities are filled, mimicking the area of the lesion with the remaining healthy enamel. this effect is what has led clinicians to adapt this treatment for the management of enamel defects. given the growing interest in the treatment of opacities in the anterior sector, due to the demanding contemporary aesthetic requirements, and the increased acceptance of minimally invasive therapies, the need has been seen to seek greater predictability for the treatment of defects. of conservative enamel from an early age and offer effective therapeutic alternatives.


Eligibility criteria:
inclusion criteria: . pediatric patients, aged between 9 and 16 years. * patients who have molar incisor hypomineralization, any lesion with isolated opacities or discoloration of the permanent incisors. * patients who present at least one opacity in the central incisors. * go to the dental clinic for revision or treatment of the university of valencia. exclusion criteria: * opacities with loss of enamel or tooth structure, active caries lesions, clinical symptoms of irreversible pulpitis such as spontaneous pain or persistent pain, a history of using bleaching agents, with intolerance to any milk protein, who have an allergic pathology or syndromic or uncooperative during the clinical procedure.
effectiveness of routine physical therapy with intensive bimanual training in cerebral palsy children

Conditions: Cerebral Palsy

Summary: effectiveness of routine physical therapy with or without home based intensive bimanual training on clinical outcomes in cerebral palsy children

cerebral palsy is one of the most common issue seen in pediatric rehabilitation .home based intensive bimanual training has proven to be one of the most effective rehabilitation training for improving motor. the study determines the effectiveness of routine physical therapy with or without home-based intensive bimanual training on coordination of hands and daily activities of daily living. a nine months randomized control trial was comprised of thirty children with unilateral spastic cerebral palsy aged between 4 to 7 years. one group received routine physical therapy and the other group received a goal specific bimanual training from their parents in their home setting for 3.5 hours per week for 6 weeks according to a modified set up. follow up sessions were done at 6th week. activities of daily living and coordination were measured using pediatric motor log activity scale and abilhand respectively.

Eligibility criteria:
inclusion criteria: * spastic cp children * both male and female * age 4-7 years * actively grasp of objects from table i.e., stuff toys, making blocks * one to one attention exclusion criteria: * cognitive delays preventing the child from following two-step instructions * health diagnoses unassociated with uscp. * parents unable to commit to entire duration of intervention. * visual difficulties preventing performance of intervention tasks.

Keywords: cerebral palsy bimanual training
topical 5-fluorouracil effervescent powder in the treatment of vitiligo

Conditions: Vitiligo; Topical Fluorouracil; Effervescent Mixture

Summary: a novel approach for 5-fluorouracil delivery based on a solid effervescent formulation is proposed . 5-fluorouracil is water soluble (\~50mg/ml) and therefore has been used for the development of novel topical formulations including nano and microparticles intended for skin targeting. after hydration 5-fluorouracil could form a complex, a suspension or even be formulated to generate effervescence. in effervescent technology, gas bubbles occur from the liquid after chemical reaction between alkali salts and organic acids (mainly citric or tartaric. due to liberation in co2 gas, the dissolution of drug in water is enhanced. the aim of this study is the development and clinical evaluation of topical 5-florouracil effervescent powder formulation in the treatment of vitiligo.


Eligibility criteria:
inclusion criteria: * patients who will be diagnosed as localized stable vitiligo. * age older than 10 years * stability of lesions for a duration of at least 1 year. * patients who didn't receive treatment for vitiligo in the previous 6 weeks before starting the study. * patients who agreed to join the study and signed written consent and continued till the end of the follow up period exclusion criteria: * patients with vitiligo patches on mucous membrane, * patients with koebner phenomenon, * other uncontrolled systemic illnesses * patients receiving any systemic or topical treatment for vitiligo

Keywords: vitiligo fluorouracil effervescent powder