Kornimate/medical-research-clean huggingface dataset:
optimal treatment for poor efficacy of entecavir in chronic hepatitis b patients

Conditions: Chronic Hepatitis b; Efficacy, Self

Summary: there are chronic hepatitis b patients with poor antiviral efficacy of entecavir in clinical practice. tenofovir or interferon alfa is the optimal choice right now. the aim of this study is to investigate the therapeutic effect of using tenofovir of interferon alfa in these patients.

there are chronic hepatitis b patients with poor antiviral efficacy of entecavir in clinical practice. poor efficacy is defined as hepatitis b virus dna is still positive and decreases \> 2 lg from baseline. sequential therapy by using tenofovir or interferon alfa is the optimal choice right now. 100 patients with poor antiviral efficacy of entecavir will be recruited in this study. they are randomly divided into tenofovir group or interferon alfa group. the aim of this study is to investigate the therapeutic effect of using tenofovir of interferon alfa in these patients.

Eligibility criteria:
inclusion criteria: 1. hepatitis b virus dna or hbsag positive for over half a year; 2. age from 18 to 65; 3. with poor efficacy of entecavir: hepatitis b virus dna is still positive at 24 weeks, and decrease \> 2 lg from baseline . 4. not be treated with interferon alfa ever before. exclusion criteria: 1. other active liver diseases; 2. cirrhosis, hepatocellular carcinoma or other malignancy; 3. pregnancy or lactation; 4. human immunodeficiency virus infection or congenital immune deficiency diseases; 5. severe diabetes, autoimmune diseases; 6. other important organ dysfunctions; 7. patients can not follow-up.

Keywords: chronic hepatitis b entecavir
a phase 3 study to assess efficacy and safety of tafasitamab plus lenalidomide and rituximab compared to placebo plus lenalidomide and rituximab in patients with relapsed/refractory (r/r) follicular lymphoma or marginal zone lymphoma.

Conditions: Follicular Lymphoma; Marginal Zone Lymphoma

Summary: this is a phase 3 double-blind, placebo-controlled, randomized study designed to investigate whether tafasitamab and lenalidomide as an add-on to rituximab provides improved clinical benefit compared with lenalidomide as an add-on to rituximab in patients with r/r fl grade 1 to 3a or r/r mzl.


Eligibility criteria:
inclusion criteria: * histologically confirmed grade 1, 2, or 3a fl or nodal mzl, splenic mzl, or extra nodal mzl * willingness to avoid pregnancy or fathering children * in the opinion of the investigator, be able and willing to receive adequate mandatory prophylaxis and/or therapy for thromboembolic events (eg, aspirin 70-325 mg daily or low-molecular-weight heparin) * previously treated with at least 1 prior systemic anti-cd20 immunotherapy or chemo-immunotherapy * documented relapsed, refractory, or pd after treatment with systemic therapy * ecog performance status of 0 to 2 exclusion criteria: * women who are pregnant or breastfeeding. * any histology other than fl and mzl or clinical evidence of transformed lymphoma * prior non-hematologic malignancy * congestive heart failure * hcv positivity, chronic hbv infection or history of hiv infection * active systemic infection * cns lymphoma involvement * any systemic anti-lymphoma and/or investigational therapy within 28 days prior to the start of cycle 1 * prior use of lenalidomide in combination with rituximab

Keywords: mor00208 incmor00208 tafasitamab
the impact of school teachers in care navigation and signposting dental caries in primary school children

Conditions: Dental Caries in Children

Summary: the study aims to investigate the role of school teachers in care navigation and signposting dental caries in primary school children.

dental caries is a multifactorial disease with high prevalence in children. dental caries is a global public health problem with detrimental impact in developing countries. despite advances in caries management and detection poorer countries continue to suffer a high burden of disease. advances in care navigation and sign-posting concepts are increasingly being utilized in general health care to aid early diagnosis and ease the burden of disease in poorer communities. this study aims to investigate the role of primary school teachers as care navigators with regard to dental caries in children.

Eligibility criteria:
inclusion criteria: healthy school children between the ages of 5-8 years regular school attender lives in the local village co-operative exclusion criteria: * known medical history or disability * irregular school attenders
pna fish, pcr and gram staining for detection of bacterial vaginosis - a comparative clinical study in a danish ivf setting

Conditions: Bacterial Vaginosis

Summary: the primary aim of the present study is to investigate the vaginal microbiota of infertile women with two novel molecular based diagnostic tests for bacterial vaginosis, a pna fish and a pcr method supported with conventional gram staining. we hypothesize that the molecular based tests will prove more efficient than conventional gram staining and that they have a place in future ivf diagnostics.

our first aim is to investigate the prevalence of altered vaginal microbiotas among women seeking fertility treatment in denmark. secondly we want to establish whether there are correlations between altered vaginal microbiotas and self-measurements of both the vaginal ph performed with the saling ph glove™ and a self-collected swab with copan eswab™ because these would be useful for an easy-access longitudinal screening option. finally, the third aim was to explore how the species composition of vaginal microbiotas measured by a multiplex qpcr assay was reflected in nugent scores. a possible 4th aim is to identify patterns in the relative abundances of different species with 16srna primers among fertile women compared with infertile women because these differences could be indicative of a vaginal microbiota associated with bad fertility outcome.

Eligibility criteria:
inclusion criteria: * seeking ivf treatment exclusion criteria: * bleeding and sexual intercourse within 24h
prevalence of detrusor underactivity and bladder outlet obstruction in female without cystocele

Conditions: Voiding Disorders

Summary: women with symptoms of voiding dysfunction may be associated with detrusor underactivity (du) or bladder outlet obstruction (boo). the treatment strategies are different between du and boo. in general, urodynamic/videourodynamic studies are important for differential diagnosis. however, urodynamic/videourodynamic studies are invasive. the investigators are interested in whether there were specific symptoms or measurements that can be used for initial differential diagnosis between du and boo. thus, the aim of this study was to elucidate the prevalence of du and boo in each age group and elucidate the clinical and urodynamic differences between the du, boo and non-du/boo groups.

between april 1996 and september 2018, all women with symptoms of voiding dysfunction who visited the urogynecological department of a medical center for urodynamic evaluation were reviewed. those women who have no complete data of maximum flow rate (qmax), voided volume, post-void residual volume (pvr) and detrusor pressure at a maximum flow rate (pdetqmax) were excluded from this study. besides, women with cystocele were also excluded. the du was defined when the pdetqmax was less than 20 cmh2o, the qmax was less than 15 ml/s, and the bladder voiding efficiency (bve) was less than 90 %. the boo was defined when the pdetqmax was not less than 40 cmh2o, and the qmax was less than 12 ml/s. bve = voided volume / (voided volume+ pvr) x 100%. those women without du or boo were allocated to the non-du/boo group. stata software was used for statistical analysis. anova test with bonferroni correction or chi-square test was used for statistical analysis as appropriate. linear regression analysis with age adjustment was used to assess the adjusted effect of variables. p \< 0.05 was considered as statistical significant.

Eligibility criteria:
inclusion criteria: * women with symptoms of voiding dysfunction. exclusion criteria: * cystocele * those women who have no complete data of maximum flow rate (qmax), voided volume, post void residual volume (pvr) and detrusor pressure at maximum flow rate (pdetqmax) were excluded from this study.

Keywords: bladder outlet obstruction detrusor underactivity voiding dysfunction
vitamin d intervention in infants

Conditions: Vitamin D Status

Summary: the study is a randomized, controlled, double blinded study evaluating the effect of recommended (400 iu) and 1 200 iu daily vitamin d substitution, given from 2 weeks to 2 years of age, on growth, bone development, neurologic and cognitive development, frequence of infectious diseases, allergic symptoms, and development of immunoregulation assessed at 2 years of age.


Eligibility criteria:
inclusion criteria: * infants born at term (37-42 wks, weight appropriate for gestational age) are included in the study exclusion criteria: * non caucasian mother * any continuous regular medication of mother * treatment at neonatal intensive care unit * antibiotic treatment of the infant * congenital malformations of the newborn * treatment with ventilation support (continuous nasal positive airway pressure) for over 24 hours * glucose infusion of the newborn * neurological symptoms of the newborn * phototherapy for jaundice of the newborn * need for nasogastric feeding of the newborn

Keywords: vitamin d infectious diseases cognitive development bone mineral density immunoregulation allergy growth
iodine-125 brachytherapy together with chemotherapy in patients with newly diagnosed glioblastoma

Conditions: Glioblastoma

Summary: the purpose of this study is to evaluate the efficacy and safety of iodine-125 brachytherapy together with chemotherapy compared with surgical resection followed by concomitant radiochemotherapy in patients with newly diagnosed glioblastoma.

this is a prospective, multicentric open-label trial to evaluate the efficacy and safety of iodine-125 brachytherapy together with chemotherapy compared with surgical resection followed by concomitant radiochemotherapy in patients with newly diagnosed glioblastoma. the primary efficacy outcome was evaluated with progression-free survival (pfs).

Eligibility criteria:
inclusion criteria: * 1. diagnosis of glioblastoma confirmed by histology * 2. age: 18-75 years old * 3. single lesion located in one hemisphere with a diameter between 2 and 6 centimeters * 4. no prior anticancer therapy for glioblastoma besides biopsy. * 5. ecog ps：0-2 point exclusion criteria: * 1. infra-tentorial tumor or tumor involves the ependymal surface. * 2. nonmeasurable disease. * 3. evidence of uncontrolled intracranial pressure. * 4. severe heart, brain, and lung diseases. * 5.severe hepatic or renal dysfunction. * 6. uncontrolled, active infection. * 7. severe clotting dysfunction. * 8. pregnant. * 9. uncontrolled hypertension. * 10. participated in any other clinical treatment trial within 4 weeks before randomization. * 11. severe vascular diseases within 6 months before randomization. * 12. participants who received major surgical treatment within 4 weeks or were expected to be treated during the trial.

Keywords: glioblastoma iodine-125 surgical resection radiochemotherapy chemotherapy radiation
efficacy of combined interferential therapy and electronic cupping therapy for chronic constipation management

Conditions: Constipation

Summary: constipation is a common gastrointestinal issue affecting individuals worldwide. interferential therapy, a form of electrotherapy, has been suggested to have potential benefits in improving gastrointestinal motility and relieving constipation symptoms. introducing of a new method like electronic cupping therapy with interferential therapy may optimize the therapeutic outcomes by potentially increasing bowel movements and improving overall gastrointestinal function.

objective: the purpose of this study was to assess the effectiveness of a combined treatment regimen that includes interferential therapy and electronic cupping therapy on the symptoms of chronic constipation, as well as gastrointestinal health outcomes. methods: this study involved 110 patients with chronic constipation, consisting of 60 females and 50 males, ranging in age from 20 to 40 years. each participant underwent evaluations using abdominal ultrasonography and a standardized constipation scoring system. all participants were allocated into three groups; group (a) received interferential therapy with aerobic exercises, group (b) received electronic cupping therapy and aerobic exercise in the form of treadmill exercise and stationary bicycle 3 sessions/week for four weeks, and group (c) received interferential therapy, electronic cupping therapy in addition to aerobic exercises.

Eligibility criteria:
inclusion criteria: * history of chronic constipation (cc), as defined by either experiencing two or fewer complete spontaneous bowel movements (csbms) per week for a minimum of 6 consecutive months before the screening visit * reporting a sensation of incomplete evacuation or straining during at least a quarter of their bowel movements (according to the generally accepted definition of constipation). * patients must have had cc persisting for more than 6 months, failed to respond to or be intolerant of medical treatment for at least 3 months exclusion criteria: * pregnant or lactating women * chronic constipation (cc) resulting from anorectal malformations such as colorectal or anal organic lesions, pelvic floor disorders requiring surgical intervention as determined by the investigator (such as rectal prolapse, rectocele, or enterocele) * presence of implanted electronic devices like cardiac pacemakers, defibrillators, cardiac pumps, or spinal stimulators * cc attributable to medications or neurologic, endocrine, or metabolic conditions * prior history of partial colectomy; conditions like megacolon, megarectum, or colonic inertia * skin abnormalities that hinder the placement of electrodes * women lacking adequate contraception (hormonal or intrauterine device).

Keywords: chronic constipation interferential therapy electronic cupping therapy
a study of ibi302 in patients with namd

Conditions: Neovascular Age-related Macular Degeneration

Summary: this is a multi-center, randomized, double-blind, active-controlled study to evaluate the efficacy and safety of ibi302 in subjects with neovascular age-related macular degeneration.


Eligibility criteria:
inclusion criteria 1. male or female patient ≥ 50 yrs. of age. 2. active subfoveal or parafoveal cnv secondary to neovascular amd. 3. bcva score of 24-73 letters using etdrs charts in the study eye. 4. willing and able to sign informed consent form and comply with visit and study procedures per protocol. exclusion criteria 1. concomitant diseases that may cause subjects fail to respond to the treatment or confuse the interpretation of the study results; 2. presence of uncontrolled glaucoma in the study eye (defined as iop≥25mmhg despite the standardized treatment); 3. presence of active intraocular or periocular inflammation or infection; 4. prior any treatment of following in the study eye: 1. anti-vegf therapy or anti-complement therapy within 3 months prior to screening; 2. laser photocoagulation within 3 months prior to screening; 3. photodynamic therapy or vitreoretinal surgery; 4. intraocular glucocorticoid injection within 6 months prior to enrollment; 5. presence of any systemic disease: including but not limited toactive infections (such as active viral hepatitis); unstable angina; cerebrovascular accident or transient cerebral ischemia (within 6 months prior to selection); myocardial infarction (within 6 months prior to selection); serious arrhythmia requiring medical treatment; liver, kidney or metabolic diseases; or malignant tumor; 6. history of severe hypersensitivity/allergy to active ingredients or any excipients of the study drug, or fluorescein and povidone iodine; 7. pregnant or lactating women or women preparing to become pregnant or breastfeeding during the study period; 8. participated in any clinical study of any other drug within three months prior to enrollment, or attempted to participate in other drug trials during the study; 9. other conditions unsuitable for enrollment judged by investigators
wenzhou gestational diabetes cohort

Conditions: Gestational Diabetes Mellitus; Intrauterine Hyperglycemia; Birth Outcome, Adverse; Nutrition, Healthy

Summary: the wenzhou gestational diabetes cohort (wgdc) is a prospective cohort study among women with gestational diabetes mellitus (gdm) during pregnancy and their offspring living in wenzhou, china. the primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with gdm over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. another aim of the wgdc is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. the secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.

in china, an alarming increase in the prevalence of gdm has been observed in the past decade. gdm is of concern because it is associated with several maternal and fetal medical disorders. lifestyle changes such as diet and physical activity modifications are key for the prevention and treatment of gdm. however, the associations between dietary intake and physical activity and health outcomes for gdm women and their children remain unclear due to subjective measurements of diet and physical activity. recently, the development of objective measurements such as food image identification and wearable activity trackers give an opportunity to gain more precise insight into these associations. in addition, for the same food and physical activity exposure, gdm women may have different blood glucose responses, but the nature of variation is currently poorly characterized. therefore, the present wgdc design incorporates three unique components, 1) objective measurement of physical activity during pregnancy using accelerometer; 2) measurement of dietary intake using both food frequency questionnaire and daily dietary records; 3) measurement of blood glucose levels over 2 weeks using continuous glucose monitors, with three standardized test meals during the 2 weeks. we will then follow up these women participants during and after this pregnancy, and also follow up their offspring.

Eligibility criteria:
inclusion criteria: * women aged 18 years or older * women with gdm mainly at 24-28 weeks of gestation * women intended to deliver at wenzhou people's hospital * women intended to remain in wenzhou with their child for ≥4 years exclusion criteria: * women with cancer and other serious medical disorders

Keywords: precision nutrition host and microbiome birth outcomes
frequency of food allergy confirm by oral food challenge among foods avoidance in atopic dermatitis children

Conditions: Atopic Dermatitis; Food Allergies

Summary: atopic dermatitis can be caused by several factors, including food allergy. currently, the diagnosis of food allergy often performing skin tests and measuring specific ige foods that many studies have shown that about 53% of children with atopic dermatitis have food sensitization, result in avoidance of food intake. but only 15% are confirmed to have a true food allergy, so the purpose of our study is to find the prevalence of food allergy in thai children with atopic dermatitis who are avoiding some foods, using the oral food challenge to confirm the diagnosis to reduce unnecessary food avoidance and prevent complications from inappropriate dietary restrictions

all subject in this study were patients with history of atopic dermatitis and avoid at least 1 food of egg yolk, egg white, cow milk, peanut, wheat or soy. all of them will undergo a blood testing for specific ige foods to assess whether they can resume consuming that particular food or they must perform oral food challenge test in hospital to evaluate whether they truly have a food allergy or should continue to avoid that food. the primary outcome was to study frequency of food allergy confirm by oral food challenge among foods avoidance in atopic dermatitis children, focusing on the 6 major food allergens in the thai children: egg yolk, egg white, cow milk, peanut, wheat and soy. other outcomes were study type of food reaction after oral food challenge test in atopic dermatitis children (ige mediated, delayed type: ad flare)

Eligibility criteria:
inclusion criteria: * age ≤ 6 years * age ≤ 6 years with diagnosis of atopic dermatitis c * now parent report them avoid at least 1 food of egg yolk, egg white, cow milk, peanut, wheat or soy exclusion criteria: * specific ige food \> 95%ppv (73-74%ppv in wheat, soy) * patients with uncontrolled asthma/ atopic dermatitis * patients who had been treated with some other immunotherapy e.g. scit, oit * patients with delayed developmental problem or mental disorder * patient use beta-blocker, acei, arb * patient who unable to follow up

Keywords: atopic dermatitis food allergies oral food challenge test
the haemodynamic effects of mechanical standard and active chest compression-decompression during out-of-hospital cpr

Conditions: Cardiac Arrest

Summary: the aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (lucas™ 2) compared to a new version generating chest compressions and active decompression above the initial starting position of the suction cup (lucas™ 2ad).

based on randomization patients will receive standard or active compression decompression chest compression and the haemodynamic effects will be compared.

Eligibility criteria:
inclusion criteria: * unexpected adult out-of-hospital non-traumatic cardiac arrest where an attempt of resuscitation is considered appropriate in: * patients 18 years or older exclusion criteria: * traumatic cardiac arrest * age believed to be less than 18 years * known pregnancy * victim not to be resuscitated (dnr orders) * internals in prison * included once in the study already * to small/large patients * sustained rosc occurring before the lucas™ 2 or lucas™ 2-ad can be applied to the patient, such that further cpr is not needed

Keywords: mechanical cpr hemodynamics