Kornimate/medical-research-clean huggingface dataset:
auricular pressure for postoperative pain after hemorrhoidectiomy: a randomized controlled trial

Conditions: Postoperative Pain

Summary: auricular pressure is effective for postoperative analgesia after hemorrhoidectomy, but the evidence is not sufficient.

this is a randomized, double-blind study to study the analgesic effect of auricular pressure pill on persistent pain after hemorrhoidectiomy. baseline pain intensity scores (vas\>3) of the subjects will be collected 24 hours after the operation of the patients. eligible subjects will be randomly assigned to receive auricular pressure pills or sham-auricular pressure pills. the treatment will last 5-7 days. participants will receive auricular pressure once two days, and receive vas, concomitant medication, ponv intensity scale and peripheral edema were recorded daily, and after the operation 24 hours, 3 days and 7 days the patients will receive anxiety and depression scale(had) , and vas data will be collected by telephone at 3 and 6 months after the operation. the statistical analysis results will be subject to the full analysis set (fas) results, and a sensitivity analysis will be performed comparing the per-protocol (pp). the main indicators will be analyzed by covariance analysis, with vas results as the dependent variable, grouping as the random factor, and age, course of disease, surgical method and baseline as the covariables to correct the p value. the secondary indicator analgesic usage rate will be analyzed using logistic regression analysis. whether analgesic will be used as a dependent variable, grouping as a random factor, and age, course of disease, surgical method and evaluation time point will be analyzed as covariables. other outcome indicators will be analyzed by covariance analysis, and the model will be the same as that of the main indicators. p\<0.05 considered as significant difference, and spss20.0 used for analysis. the purpose of this study was to seek high quality evidence-based medical evidence for intervention of auricular pressure pills on postoperative pain of hemorrhoidectomy.

Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria of grade ii-iv mixed hemorrhoids and meet the operation conditions; 2. age 18\~65; 3. external stripping and internal ligation of mixed hemorrhoids, general anesthesia or lumbar shu point anesthesia; 4. vas score ≥3 points after the implementation of analgesia pump; 5. improve clinical auxiliary examination and sign informed consent. exclusion criteria: 1. combined with inflammatory hemorrhoids, thrombotic hemorrhoids, perianal eczema, perianal abscess and other perianal diseases that affect the evaluation of curative effect; 2. combined with intestinal infectious diseases, intestinal polyps, rectal malignant tumors, etc; 3. combined with severe cardiovascular disease, immune deficiency, mental disorder, or severe liver and kidney dysfunction; 4. auricle skin lesions or auricle skin allergy to tape is difficult to tolerate treatment; 5. combined cognitive impairment could not complete the efficacy; evaluation; 6. pregnancy or planned pregnancy.

Keywords: hemorrhoidectiomy postoperative pain auricular pressure
dysfunctional adiposity and glucose impairment

Conditions: Body Composition; Visceral Obesity; Carbohydrate Intolerance; Obesity, Abdominal; Cardiovascular Risk Factor; Beta-cell Function; Insulin Resistance; Oral Glucose Tolerance Test

Summary: this is a large and comprehensively phenotyped cohort with fasting glycaemia where the predictive value of body composition and anthropometric measures of total and central fat distribution for postprandial carbohydrate intolerance are studied.

subjects aged 18-70 years, who attended the department of endocrinology and nutrition of the clínica universidad de navarra from 2009-2014 for a check-up were offered to participate in the dicamano study. 853 subjects agreed to take part. only those individuals with a normal fasting glucose level (≤5.5 mmol l-1) were analysed. subjects with t2dm or severe renal, liver or thyroid dysfunction were excluded. participants were instructed to temporarily discontinue for 48 hours any medication known to affect glucose or lipid metabolism. on the day of the study visit, each subject had a complete routine clinical assessment to evaluate the presence of cardiovascular, respiratory, renal or endocrine disorders. all patients underwent a 75-g ogtt with a concomitant anthropometric study, blood pressure monitoring and lipid profile analyses. they were classified by glucose tolerance on the basis of blood glucose levels according to ada diagnostic criteria for t2dm (2017). carbohydrate intolerance was defined as a 2-hogtt glucose level ≥7.8 mmol l-1 (mg dl-1). body composition, visceral adipose tissue, anthropometry study, ogtt-based parameters and cardiovascular risk factors are measured.

Eligibility criteria:
inclusion criteria: * fasting glucose level ≤ 5.5 mmol l-1 * bmi ≥ 25 exclusion criteria: * type 2 diabetes mellitus * severe renal, liver or thyroid dysfunction
neuropathic pain in children: multimodal assessment and diagnosis

Conditions: Neuropathic Pain; Child, Only

Summary: some children experience chronic pain that is related to damage or diseases that affect the nerves that send pain signals. this is known as neuropathic pain. this is not well understood and can be difficult to diagnose. it can often produce unusual feelings such as sensitivity of the skin to light touch. neuropathic pain is often severe and difficult to treat, and can affect quality of life for the child and family. this study aims to better characterise the symptoms and signs, and impact of neuropathic pain in children.

the investigators will determine whether a questionnaire to identify neuropathic pain in adults is also useful in children. this will help paediatricians and other doctors to recognise neuropathic pain and start appropriate treatment or know when to refer children to a chronic pain clinic.the investigators will also measure the effects of neuropathic pain on mood, sleep, and quality of life (using questionnaires); identify changes in the sensitivity of the skin to touch and other sensations (using specialised sensory tests); and determine the feasibility of brain imaging for assessing changes in the brain (using magnetic resonance imaging or mri), in children with neuropathic pain. this information will allow the investigators to measure how effective different types of treatment are, and help ensure children get the most appropriate treatment or interventions to reduce pain and effects on quality of life. this pilot study of 10-18 year olds diagnosed with neuropathic pain will involve completion of questionnaires by the child and parent, and sensory testing in the child, after their clinic appointment. for some families, there will be an additional visit for mri. children will be recruited from the chronic pain outpatients service at great ormond street hospital nhs trust. this research is funded by great ormond street hospital children's charity.

Eligibility criteria:
inclusion criteria: * children with a clinical diagnosis of chronic neuropathic pain for the full protocol * children with a clinical diagnosis of non-neuropathic origin for s-lanss validation and questionnaires * children aged 10-18 years exclusion criteria: * significant impairment of comprehension (less than school level for 10 year old) that will limit understanding of sensory testing instructions * inadequate english language skills as questionnaires are validated in english and sensory testing instructions can only be delivered by the investigators in english for brain imaging, patients will be excluded if they have * significant medical illness or other (non-neuropathic) neurological disease * pregnancy * magnetic implants of any type.

Keywords: pain neuropathic children qst
microbiome fructan metabolism and symptoms in childhood ibs

Conditions: Irritable Bowel Syndrome (IBS)

Summary: this study evaluates whether the gut microbiome is involved in determining whether children with irritable bowel syndrome (ibs) develop worsening gi symptoms (e.g. pain) when given fructans (a sugar often found in wheat). participants will both receive a diet with fructans and a diet without fructans.

fructans (fructo-oligosaccharides) are a type of carbohydrate which can not be hydrolyzed by humans. it is commonly found in wheat in the american diet. after ingestion they arrive essentially intact into the colon where they are metabolized by the colonic microbiome. fructan avoidance has been found to help decrease gastrointestinal symptoms (e.g. pain) in those with ibs. however not all individuals with ibs have worsening symptoms when eating fructans in their diet. this study seeks to evaluate whether the microbiome is involved in determining whether an individual with ibs has worsening symptoms with fructan ingestion. following a one week baseline period, participants will be randomized in a double-blind cross-over fashion to either a 72 hour meal period with fructans or a 72 hour meal period with maltodextrin (placebo). a washout period of at least 10 days will occur in between. symptoms will be captured using a stool and pain diary. stool specimens and urine specimens will be obtained at baseline and during the dietary interventions. breath hydrogen testing will be obtained during the dietary interventions.

Eligibility criteria:
inclusion criteria: * children ages 7-17 years * children with ibs will meet rome iii criteria per the rome iii questionnaire * healthy children will not have chronic conditions * english speaking and able to read/write in english exclusion criteria: * previous bowel surgery * documented gastrointestinal disorder (e.g. ulcerative colitis) * serious chronic medical condition (e.g. diabetes) * weight and/or height are greater than or less than 2 standard deviations for age * chronic conditions with gi symptoms (e.g. cystic fibrosis) * antibiotics within the past 3 months * pregnancy * autism spectrum disorder and/or significant developmental delay * mood disorders (e.g. major depression) * known post-infectious etiology
life enhancing activities for family caregivers

Conditions: Stress; Dementia; Affect

Summary: life enhancing activities for family caregivers is a six-week program designed to increase positive affect in people who care for a family member with dementia. the intervention consists of 6 weekly one-hour sessions conducted one-on-one with a trained facilitator to teach simple skills that are practiced at home in a study-supplied workbook. the program is preceded and followed by a 30-45 minute questionnaire. follow-up assessments will be conducted at 1-month, 3-months, and 6-months post intervention. primary hypothesis is that experimental subjects who participate in leaf will demonstrate significantly greater improvements in psychological outcomes and will engage in more problem focused and positive appraisal forms of coping compared to the wait-list control condition.

all study activities can be conducted from the participant's home, making participation possible for any qualified caregiver with computer and wifi access, in any u.s. state. the leaf study will supply the tablet computer, software, and workbook required for participation.

Eligibility criteria:
inclusion criteria: * participants must be able to be defined as the primary care provider for a family member with dementia. (person with dementia must live with the caregiver or in their own home and not in a care facility.) * must speak and read english * must have the ability to provide informed consent exclusion criteria: * lack of access to a high speed internet connection * evidence of severe cognitive impairment or active psychosis, as assessed by trained interviewers

Keywords: positive affect caregivers caregiving stress mood dementia alzheimer's ftd lewy mindfulness help
technology-enabled patient support system for self-management of cf

Conditions: Cystic Fibrosis

Summary: this project will test a technology-enabled patient support system (pss) as a self-management tool for children with cf and their family caregivers.

the goal of this study is to refine and test a technology-enabled patient support system (pss) as a tool for self-management of pediatric cf. the pss includes two components: 1) patient-facing: an app with customizable dashboards for tracking patient-generated outcome measures and providing personally relevant decision-making support; and 2) clinic-based: clinical patient management and technical support. using a one-group pretest-posttest design, we will evaluate the effect of the adapted technology-assisted pss on patient-reported outcomes (pros). study hypothesis: among pediatric cf patients treated at the uab cf center, the use of technology-aided pss over 6 months will improve health-related quality of life (primary outcome) as well as patient satisfaction, patient activation, and shared decision-making (secondary outcomes).

Eligibility criteria:
inclusion criteria: diagnosis of cystic fibrosis - exclusion criteria: none -
national survey of symptoms of people aged 70 and overs diagnosed with covid-19

Conditions: SARS-CoV-2; COVID-19

Summary: cross-sectional study based on a french national survey aimed to described and identify the most frequent symptoms of covid-19 older patients.

this cross-sectional survey was initiated and conducted by the french society of geriatrics and gerontology. a standardized questionnaire was emailed to 1600 geriatrician members of the french society of geriatrics and gerontology throughout france between march 22, 2020 and april 5, 2020. geriatricians were asked to complete the survey for their last 10 patients infected by the sars-cov-2. the study was declared to the commission nationale de l'informatique et des libertés (cnil) under the number ar20-0031v1. for each patient, demographic characteristics (age, gender, residence place, care place, autonomy according to the groupe iso ressource (gir)), medical history (presence of major neurocognitive disorder, hypertension, diabetes, asthma or chronic obstructive pulmonary disease (copd), heart pathology, severe renal failure with a clearance of creatinine under 30ml/min, solid or liquid cancer) were collected. the symptoms within de 72 hours of the actual disease were also collected for each patient including geriatric syndromes (fall, hypoactive or hyperactive delirium, altered general status, altered conscience), general symptoms (temperature, blood pressure), respiratory symptoms (cough, polypnea), ear nose and throat (ent) symptoms (rhinorrhea, odynophagia, otalgia, conjunctivitis, ageusia or dysgeusia, anosmia), digestive symptoms (diarrhea, nausea or vomiting), and blood formula modification (leucopenia (with count if available), lymphopenia (with count if available), thrombopenia (with count if available). procedure data were collected by the physician who was in charge of the patient between march 22, 2020 and april 5, 2020. given the main objective of the study was only descriptive, no calculation was required concerning the number of subjects to include in the study.

Eligibility criteria:
inclusion criteria: * confirmed covid-19 defined by a positive rt-pcr to sars-cov-2 exclusion criteria: * none
static and dynamic core stability exercises in potpartum back pain

Conditions: Back Pain

Summary: to compare the effects of static exercises with dynamic core stability on pain and disability in postpartum back pain.

the study comprised 28 participants. the individuals were subdivided into binary groups, group a performed static exercises and group b performed dynamic exercises including swiss ball, each containing 14 subjects. baseline treatment (hot pack, tens and posture correction) to both groups was given along with core stability exercises. core stability exercises were performed on both group for 4 weeks. the pretreatment and post treatment tests are measured using the scale vas (visual analog scale) and oswestry disability index questionnaire. both groups have shown the improvement in postpartum lumber pain and an improved in daily life activities. but swiss ball exercises have more significant improvement on pain and disability in patients having postpartum lumber pain.

Eligibility criteria:
inclusion criteria: * age groups of 18 to 35 * pain more than 4/10 on vas * without referred pain to lower limbs * women with normal delivery exclusion criteria: * nulliparous women * osteoporosis and oa * systemic arterial hypertension * hypersensitivity to electrical modalities * any fracture (spine, rib) or injury * any abdominal surgery * any other general ailment * vertebral or disc pathologies

Keywords: pain and disability in postpartum
a survey for factors that influence postoperative treatment decision-making for hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: this is a non-interventional and questionnaire survey study. the investigators try to find out patient's willingness and expectation for post-operative treatments for hepatocellular carcinoma (hcc), as well as patients' willingness to participate in clinical trials using a questionnaire. the ultimate goal is to assist physicians in clinical treatment decision, clinical research, and government health and economic decision-making, as well as to help investigators understand how to increase public awareness of the hcc and the treatment course and efficacy of hcc, and the awareness of clinical trials.

there is no world widely accepted adjuvant therapy for hcc and the guidelines from aasld or easl did not recommend any adjuvant therapy to prevent postoperative tumor recurrence of hcc. the goal of an adjuvant therapy is to meet the requirements of patients, which are influenced by many factors such as the strength of doctors' recommendation, economic affordability, tolerance of adverse reactions to treatment, and expectation of efficacy. therefore, understanding patients' expectations for an adjuvant therapy after surgery will help doctors give more reasonable treatment. participating in clinical trials is a new process of understanding and acceptance for each patient, so investigators try to understand the willingness and ideas of patients to participate in clinical trials, so as to provide more information for designing clinical trials and recruiting subjects for clinical trials. the research was conducted through face-to-face interview, wechat and telephone interview. for face-to-face interview and wechat to participants, an informed consent should be signed.

Eligibility criteria:
inclusion criteria: * male or female aged 18 years or older; * confirmed diagnosis of hcc histologically or clinically; * the participant must have received surgical resection; * ability to complete the questionnaire or independently or with the help of a friend, relative, or staff member of the oncology department. exclusion criteria: * the patients that researchers consider not suitable to participate in this study.
the effect of vitamin d3 on the rate of orthodontic tooth movement

Conditions: Tooth Position Anomalies

Summary: the aim of this study is to evaluate the effect of vitamin d3 deficiency on the rate of orthodontic tooth movement in both conventional and accelerated orthodontic. assessing both lower anterior teeth alignment and the rate of maxillary canine retraction.

to evaluate the effect of vitamin d deficiency on the rate of orthodontic tooth movement in both conventional and accelerated orthodontic, additionally find the effect of vitamin d deficiency on molar anchorage loss, canine rotation, lower incisor crowding alignment time, pain experienced by the patient during otm and rate of orthodontically induce apical root resorption.

Eligibility criteria:
inclusion criteria: 1. age ranged from 18 to 30 years, from both sex. 2. healthy general medical condition, healthy periodontal condition. 3. malocclusion that requires extraction of the maxillary first premolars, followed by canine retraction, with moderate lower incisor crowding (little's irregularity index 3-6mm). 4. normal shape and structure of maxillary canine, with no history of filling or root canal treatment and normal shape and structure of maxillary first molar. exclusion criteria: 1. pregnant women. 2. patient with renal or liver disease. 3. patient taking corticosteroid or anticonvulsant drugs. 4. patient with thyroid or parathyroid problems.

Keywords: orthodontic, tooth movement, acceleration
testing the effectiveness of a graphic novel health education curriculum for patients with addiction

Conditions: Alcohol Use; Drug Use

Summary: this study deploys a strategy to develop and evaluate a training-efficient, multimedia patient-centered health education toolkit to promote shared decision making between counselors and patients. an existing evidence-based toolkit intervention will be adapted and redesigned by a patient and provider team into an engaging, narrative graphic novel curriculum useful in group and individual counseling. the proven behavioral interventions will be augmented with health education material focused on medication assisted treatment (mat). we will assess feasibility and acceptability, and pilot test whether exposure to the toolkit (tk) can shared decision making conversations, reduce substance use, and increase engagement with mat.

an existing evidence-based toolkit intervention will be adapted and redesigned by a patient and provider team into an engaging, narrative graphic novel curriculum useful in group and individual counseling. the proven behavioral interventions will be augmented with health education material focused on medication assisted treatment (mat) and hiv risk reduction. together, these materials will comprise the health education toolkit. the health education toolkit (tk) will employ a shared decision making model to encourage 1) increased recovery engagement by patients, and 2) patient engagement in deciding whether to initiate and adhere to mat. we will conduct a randomized pilot trial of 50 patients with active alcohol substance use disorders (suds) enrolled in inpatient or outpatient treatment and will follow them over 3 months. we will test whether patients randomized to receive the tk curriculum will report increased shared decision making conversations, report greater satisfaction and acceptability of their treatment sessions, demonstrate larger reductions in substance use (drug and alcohol) and increases in abstinence, demonstrate improved alcohol severity scores, attend more attendance at specialty substance abuse intervention and treatment sessions, and demonstrate greater rates of initiating mat for alcohol dependence over the 3-month follow-up period as compared to patients receiving treatment-as-usual (tau).

Eligibility criteria:
inclusion criteria: * 18 years or older * screening score of at least 16 on the audit * meets criteria for a dsm-v substance use disorder as assessed via the mini plus 5.0. * reports at least two heavy drinking episodes in the previous 4 weeks exclusion criteria: * reports plans to leave the philadelphia greater metropolitan area within the next 6 months * does not speak english * unable to provide valid informed consent