Kornimate/medical-research-clean huggingface dataset:
efficacy of high-intensity laser acupuncture in patients with chronic, non-specific low back pain

Conditions: Chronic Nonspecific Low-back Pain

Summary: the purpose of this study is to investigate the efficacy of high-intensity laser acupuncture on peak torque, power of trunk extensors and flexors, back pain, range of motion, function, and satisfaction in patients with chronic nonspecific low back pain (cnlbp).

chronic nonspecific low back pain (cnlbp) is a persistent back pain that affects people of all ages and contributes to the global disease burden. treatment focuses on reducing pain and its consequences. high-intensity laser therapy is a non-invasive, painless modality that can be easily administered for various conditions. it has been proven to significantly reduce pain, with anti-inflammatory, anti-edematous, and analgesic effects. laser photobiomodulation (pbm) therapy is a non-invasive and painless method that stimulates cells, pain receptors, and the immune system and can cause vasodilation and analgesic effects. acupuncture is a common complementary therapy that has been proven to treat musculoskeletal pain and enhance muscle strength, and high-intensity laser acupuncture (hila) has been promoted as an alternative to traditional needle acupuncture. hila, as a non-invasive treatment, combines the efficacy of high-intensity laser and acupuncture in musculoskeletal pain management. due to a lack of research, this study will examine the effects of hila on peak torque and power of the trunk extensors and flexors, back pain, range of motion, function, and satisfaction in patients with chronic non-specific low back pain.

Eligibility criteria:
inclusion criteria: 1. the patients had cnslbp with age from 20 to 40 years from both genders. 2. patients will be referred from an orthopedist with diagnosis of chronic low back pain without underlying pathological causes. 3. the patients with chronic nonspecific low back pain more than 3months. minimum pain intensity of 30 mm on the visual analogue scale (vas) for pain, which ranges from 0 to 100 mm. 4. patients with normal bmi ranges between 18.5:24.9 kg/m2. 5. the study populations must be willing to participate in the study exclusion criteria: 1. neurological, infectious diseases and systemic illness such as rheumatologic diseases,systemic lupus erythematosus, diabetes mellitus type i or ii. 2. psychiatric/mental deficit. 3. patients who had a previous surgical history (within 6 months) will also excluded. 4. participation in other treatment within the previous 3 month. 5. pregnancy. 6. history of spinal fracture, tumor, osteoporosis 7. use of medication, such as corticosteroids, anticonvulsants, and anti-inflammatory drugs that may affect the outcome of the study. 8. prior history of adverse effects to physical stimulation therapy. 9. significant physical or mental deficiencies preventing a clear understanding of the study procedure. 10. spinal stenosis, thyroid dysfunctions, obesity, pace-maker.

Keywords: low back pain high-intensity laser acupuncture peak torque power functional disability
analysis of risk factors and prognosis of pediatric patients after operations for congenital heart disease

Conditions: Congenital Heart Disease; Pediatric

Summary: this hospital-based retrospective study reviewed patients who underwent surgery for chd between 2017 and 2020 and analyzed the clinical features and outcomes associated with airway anomalies.


Eligibility criteria:
inclusion criteria: * all pediatric patients (age \<18 years) who underwent surgery for chd at our hospital between january 1, 2017, and december 31, 2020. exclusion criteria: * with much missing clinical data
clinical evaluation of two monthly contact lenses

Conditions: Refractive Errors

Summary: the purpose of this study is to explore overall vision with biofinity® energys™ contact lenses as compared to biofinity® contact lenses after one week of wear.


Eligibility criteria:
inclusion criteria: * able to understand and sign an approved informed consent form (icf); * successful wear of biofinity® (spherical) (or private label) contact lenses in both eyes for a minimum of 5 days per week and 8 hours per day during the past 3 months; * best-corrected visual acuity (bcva) 20/25 or better in each eye; * possess spectacles that provide a corrected visual acuity of 20/40 or better in both eyes (ou) and be willing to wear them (as needed); * currently using digital devices (computer, tablet, and/or smart phone) for a minimum of 5 days per week and 4 hours per day; * other protocol-specified inclusion criteria may apply. exclusion criteria: * any anterior segment infection, inflammation, abnormality or disease that contraindicates contact lens wear; * any use of systemic or ocular medications for which contact lens wear could be contraindicated; * refractive, ocular, or intraocular surgery, as specified in the protocol; * current or history of eye injury or disorders, as specified in the protocol; * current or history of intolerance, hypersensitivity or allergy to any component of the study products; * habitual contact lens wear in an extended wear modality (routinely sleeping in lenses for at least 1 night per week) over the last 3 months prior to enrollment; * use of topical ocular medications that would require instillation during contact lens wear; * other protocol-specified exclusion criteria may apply.
my-endo -- mind your endometriosis: a digital mindfulness- and acceptance-based endometriosis self-management program

Conditions: Endometriosis

Summary: the purpose of the study is to assess the effect of a digital mindfulness- and acceptance-based psychological intervention on quality of life, work ability, pain experience and physical and mental health in participants experiencing chronic pain, fatigue and/or reduced quality of life due to endometriosis.


Eligibility criteria:
inclusion criteria: * ≥18 years old. * signed informed consent. * endometriosis diagnosed by a gynecologist based on the medical case history, ultrasound, laparoscopy, or mri (all self-reported). * moderate to severe symptoms (pelvic pain and/or fatigue measured on an 11-point numeric rating scale (nrs) from 0 = no pain/fatigue to 10 = worst imaginable pain/fatigue symptom) or reduced endometriosis-related quality of life (measured by the ehp-30): * moderate to severe endometriosis-related chronic pelvic pain (nrs \> 2) or * moderate to severe endometriosis-related fatigue (nrs \> 2) or * low endometriosis-related quality of life (one or more ehp-30 subscale mean scores ≥ 40.00). * relevant clinical and/or surgical treatment according to the european society of human reproduction and embryology (eshre) guidelines for endometriosis has been attempted. * willingness to practice mindfulness and yoga at home for 30-45 minutes 5-7 days a week during the treatment period. exclusion criteria: * under 18 years old. * severe psychiatric diagnosis made by a psychiatrist and/or ongoing psychiatric treatment. * pregnancy or planned pregnancy during the study period. * an estimated lack of capacity or surplus energy to enter into a digital mindfulness treatment, for instance, because of: * major life events taking place at the same time (e.g., divorce, loss of a close relative, etc.) * linguistic or cultural barriers

Keywords: endometriosis quality of life digital psychological interventions randomized controlled trial mindfulness-based intervention acceptance and commitment therapy pelvic pain
bdnf level and val66met polymorphism of brain derived neurotropic factor gene in patients with t2dm and depression

Conditions: Depression; Diabetes Mellitus

Summary: this study aimed to evaluate the relation between the levels of (brain derived neurotropic factor) bdnf and val66met polymorphism of bdnf gene, and the presence of depression in type 2 diabetes. in addition to studying the relationship between bdnf level and val66met polymorphism of its gene and assessing relation between bdnf level and obesity.

the study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. depression was assessed by hamilton depression rating scale (ham-d) and structured clinical interview for dsm-iv axis disorder (scid-i) for diagnosing depression and exclusion of other psychiatric disorders. genotyping was performed by using real time-pcr (taqman probes).

Eligibility criteria:
adult patients who have type two diabetes with or without depression.

Keywords: brain derived neurotrophic factor diabetes mellitus
development of multi-specific antibodies based on immune microenvironment of breast cancer

Conditions: Invasive Breast Cancer

Summary: this is a prospective, single-center, non-randomized, non-controlled study

immunotherapy with immune-checkpoint inhibitors (icis) has enabled a leap forward in the treatment of various types of cancer within the past decade. however,only 12.46% of patients with cancer are expected to respond to icis.our team have recently developed a multi-specific antibody technology platform for the microenvironment of solid tumors. in this study, we are going to study the tumor immune microenvironment of breast cancer patients by patient-derived organoids or pdx model，to design multi-specific antibody drugs for different tumor immune microenvironment，to look forward to improve the effectiveness of immunotherapy for breast cancer and solve the problem of drug resistance.

Eligibility criteria:
inclusion criteria: 1. women between 18 and 70 years old； 2. primary lesion \>2cm on imaging examination, or suspected axillary lymph node metastasis on imaging examination； 3. previous not received preoperative radiotherapy, chemotherapy, endocrine therapy, immunotherapy, or other anticancer treatments； 4. subjects signed informed consent； exclusion criteria: 1. a history of prior or concomitant malignancies; 2. advanced stage breast cancer (stage iv)； 3. suspected or confirmed lesion was surgically removed； 4. patients were accompanied by severe organic diseases such as heart and cerebral disease, and liver and kidney disease.；
efficacy and safety of brolucizumab vs. aflibercept in patients with visual impairment due to diabetic macular edema

Conditions: Diabetic Macula Edema

Summary: the purpose of this study is to evaluate the efficacy and safety of brolucizumab in treatment of patients with visual impairment due to diabetic macular edema (dme).

in this 48-week, randomized, double-masked, multicenter, active controlled study, consenting patients will be randomized in a 1:1 ratio to one of the two treatment arms and attend 14 planned visits.

Eligibility criteria:
inclusion criteria: * patients with type 1 or type 2 diabetes mellitus and hba1c of ≤10% at screening * bcva score between 23 and 65 letters, inclusive, using etdrs visual acuity testing charts at a testing distance of 4 meters (approximate snellen equivalent of 20/50 to 20/320), at screening and baseline * dme involving the center of the macula, with central subfield retinal thickness (measured from rpe to ilm inclusively) of ≥ 320 µm on sd-oct exclusion criteria: * high risk or advanced proliferative diabetic retinopathy in the study eye as per reading center * active intraocular or periocular infection or active intraocular inflammation in the study eye * uncontrolled glaucoma in the study eye defined as intraocular pressure (iop) \> 25 millimeters mercury (mmhg) * previous treatment with any anti-vegf drugs or investigational drugs in the study eye in the last 3 months prior randomization * stroke or myocardial infarction during the 6-month period prior to baseline * uncontrolled blood pressure defined as a systolic value ≥160 mmhg or diastolic value ≥100 mmhg other protocol-specified inclusion/exclusion criteria may apply

Keywords: diabetic macula edema intravitreal injection brolucizumab aflibercept double-masked
prevention of obesity at universities: a randomized trial

Conditions: Obesity

Summary: this is a nutrition and behavior-based intervention conducted at drexel university and the university of pennsylvania with college women during their freshman year. it involves attending groups where life skills and eating behaviors are taught to help them control their weight and physical health.


Eligibility criteria:
inclusion criteria: * a variety of risk factors for later life weight gain exclusion criteria: * current or past history of eating disorder
the effect of 4-7-8 breathing exercise technique on tinnitus

Conditions: Tinnitus, Subjective

Summary: the goal of this study is to evaluate the effect of 4-7-8 breathing exercise on tinnitus handicap, psychological factors and sleep quality. there will be a parallel-group randomized controlled trial study and consists of two groups. both groups will receive 1 hour of informative session on tinnitus and the experimental group will also perform 4-7-8 breathing exercises for 6 weeks. visual analog scale, tinnitus handicap inventory, insomnia severity index, trait anxiety inventory, and perceived stress scale will be applied before and after the application.

the aim of this study is to evaluate the effect of 4-7-8 breathing exercise technique on tinnitus handicap, psychological factors and sleep quality. it is also aimed to compare the results of the experimental group and those who received only 1 hour of informative session on tinnitus (control group). the study will employ a parallel-group randomized controlled trial design. both groups will receive 1 hour of informative session on tinnitus and the experimental group will also perform 4-7-8 breathing exercises for 6 weeks. visual analog scale, tinnitus handicap inventory, insomnia severity index, trait anxiety inventory,and perceived stress scale will be applied to all patients before and after the application.

Eligibility criteria:
inclusion criteria: * aged between 18-65 years with subjective idiopathic tinnitus complaints for at least six months * must be able to speak and read turkish * must be able to answer the questionnaire questions and perform the 4-7-8 breathing exercises regularly exclusion criteria: * any neuro-otologic, psychiatric, neurologic, or cognitive problems, objective tinnitus, chronic medication use, asthma diagnosis or respiratory distress * receivement of any tinnitus treatment or tinnitus informative session actively

Keywords: 4-7-8 breathing exercise tinnitus psychological factors insomnia informative session
the pk/pd study of shr2285 tablets in healthy subjects

Conditions: Thrombosis

Summary: thrombosis is a maladaptive process of vascular occlusion and remains a primary cause of cardiovascular morbidity and mortality, the dose-limiting issue with available anticoagulant therapies is bleeding. the primary objective of this study is to assess the safety and tolerability of shr2285 tablets in healthy subjects. in addition, this study will provide information on pharmacokinetics and pharmacodynamics of shr2285 tablets in healthy subjects.


Eligibility criteria:
inclusion criteria: 1. males or females, aged 18-45 2. subjects with no cardiovascular disease, sitting blood pressure: 90mmhg ≤sbp\<140mmhg and 50mmhg ≤dbp\<90mmhg; 3. body mass index (bmi) between 18 to 28, and a total body weight: male ≥50.0 kg and \<90.0 kg; female ≥45.0 kg and \<90.0 kg 4. participant in general good health. no clinically significant findings in laboratory parameters or clinically significant abnormality on x-ray exclusion criteria: 1. alanine aminotransferase (alt) or aspartate aminotransferase (ast) or total bilirubin \> 1x uln during screening/baseline; 2. abnormal coagulation function; 3. a clinical history of coagulation dysfunction；subjects with adverse reaction of antiplatelet drugs or anticoagulant drugs. 4. subjects with severe trauma or surgery within 3 months prior to the screening； 5. known blood donation within 30 days pre-dose; donating≥400 ml of blood 3 months pre-dose; 6. human immunodeficiency virus antibody (hiv-ab), syphilis serological examination, hepatitis b virus surface antigen (hbsag), hepatitis c virus antibody (hcv-ab) were positive; 7. 3 months prior to screening involved in any drug or medical device clinical subjects, or within 5 half-life of drugs before screening; 8. pregnant or serum β-hcg \> 5miu/ml at baseline or women who are breastfeeding; etc.
prospective controlled study of posttransplant diabetes

Conditions: Diabetes Mellitus; Kidney Failure

Summary: research participants will be asked to undergo complete medical history, physical examination and blood tests. the purpose of these tests is to determine whether persons are predisposed to develop diabetes mellitus after kidney transplantation and also to make an early diagnosis if a patient develops diabetes mellitus. medical information collected as part of the standard transplant evaluation and posttransplant medical care may be incorporated into this study. it is important to realize that research subjects will not be given an experimental drug as part of this study. after kidney transplantation, research subjects will be followed in the posttransplant clinic visits. the study will last up to 6 months. during this time the subjects may be asked to participate in clinical assessment visits (medical history and physical examination), and also during the third or fourth month after transplant will be asked to do a repeat glucose tolerance test.


Eligibility criteria:
inclusion criteria: * fasting plasma glucose (fpg) \<126mg/dl. * no history of diabetes mellitus or treatment with oral antidiabetic agent or insulin. * esrd or chronic renal failure with crcl \<= 20cc/min per 1.73m2. * waiting list registration for cadaveric or set date for living donor renal transplantation. * willingness and ability to understand and give informed consent.

Keywords: kidney transplantation immunology
evaluation of the modified early warning scoring system

Conditions: Clinical Deterioration; Postoperative Complications; Nurse's Role

Summary: in this study, it was aimed to determine the effect of hru and hg on patient outcomes in the care process in surgical patients followed according to meuss. the sample of the study, which was conducted as a randomized-controlled clinical trial, consisted of 252 patients who underwent surgical intervention under general anesthesia in a university hospital between 29 july 2022 and 31 october 2022.

postoperative patients are at risk of clinical worsening and minimizing this is vital. nurses play a vital role in the early detection and management of clinical deterioration as they are the group of professionals with the highest patient contact. meuss is stated as a simple risk management tool based on physiological parameters that can allow early detection of clinical deterioration and initiation of the relevant intervention, improving the quality of care and patient safety provided to surgical patients. in this study, with a larger sample, patients will be followed up with meuss and a nursing guide for 2 hours in the clinic where they are transferred both after and after asbu. our study is a research with the highest sample in this field, in which patients are followed for the longest period of time, and it is thought that meuss and nursing guide applications can identify risky patients in the postoperative period and reduce postoperative complications with strict follow-up applied to these patients. the aim of this study; to determine the effect of nursing guide practice (hru) and nursing interventions (hg) on patient outcomes in the care process in surgical patients followed according to meuss.

Eligibility criteria:
inclusion criteria: * having operated under general anesthesia * transferred to the post-anesthesia care unit (asbu) and then to the service/icu followed for 2 hours, * between 18-65 years old, * who have not had an operation with general anesthesia in the last six months, * no serious life-threatening complications developed during surgery, * patients willing to participate in the study exclusion criteria: * data unavailable, * complications during surgery, * patients who did not undergo general anesthesia

Keywords: clinical deterioration early warning score nursing assessment postoperative care surgical nursing
aurora: crestor 10mg versus placebo in subjects with end-stage renal disease (esrd)

Conditions: Renal Failure

Summary: the purpose of this study is to see if rosuvastatin helps to reduce the number of heart attacks, strokes and cardiovascular deaths in patients undergoing haemodialysis.


Eligibility criteria:
inclusion criteria: * male or female subjects with end-stage renal failure aged 50-80 years, who have received regular haemodialysis treatment for at least 3 months exclusion criteria: * subjects will have no underlying condition that is expected to limit survival to less than 1 year and is also unrelated to end-stage renal disease (esrd). subjects should not have received a statin therapy within the past 6 months

Keywords: end stage renal failure
postoperative pain after the use of different last irrigation method during root canal treatment in primary teeth

Conditions: Post Operative Pain

Summary: this study was to evaluate and compare the postoperative pain levels after using endoactivator and conventional endodontic syringe irrigation in root canal therapy of primary molars.


Eligibility criteria:
inclusion criteria: * patients exhibiting positive or definitely positive behavior on the frankl's behavior rating scale (rating 3 or 4 on the frankl's scale) * american society of anesthesiologists class 1 patients aged 5-9 years * patients with symptomatic irreversible pulpitis of maxillary primary molars confirmed using periapical radiographs, percussion, and cold test * patients having teeth with two-thirds of each root remaining * absence of periapical lesions and interradicular radiolucency * moderate to very severe (2-4) five-face scale pain scores in the 24-hour period before the procedure. exclusion criteria: * patients who had taken analgesics and antibiotics within the last 12 hours before root canal treatment * teeth with pathologic root resorption * teeth with excessive mobility.

Keywords: endoactivator irrigation postoperative pain primary teeth