Kornimate/medical-research-clean huggingface dataset:
clinical and fundamental aspects of prosthetics and translocation of mitral valve chordae

Conditions: Degenerative Mitral Valve Disease

Summary: the study compares the efficacies of two surgical procedures for the treatment of mitral valve prolapse due to myxomatous degeneration of the mitral valve: the chordae replacement and the translocation of secondary mitral valve chordae.

summary: this study compares the efficacy and the safety of two surgical procedures for the treatment of mitral valve prolapse due to degeneration of the mitral valve: chordae replacement and the translocation of secondary mitral valve chordae. in our study, researchers used the loop method proposed by von oppel and mohr in 2000. the main principle of the method of prosthetic chordae is the preservation of the native anatomy of the mitral valve. this principle is achieved by the implantation of artificial chordae made of eptfe gore-tex threads. the chordae replacement method essentially involves five stages: 1. measuring the required length of the chordae. 2. forming the loops. 3. fixation of the group of loops to the papillary muscles. 4. fixation of the chordal loops to the free edge of the valve. 5. annuloplasty with a support ring and a hydraulic test to confirm the absence of prolapse. chordae translocation is the alternative method, which does not require measurement and selection of chordae lengths. chordae replacement is technically easier (less aortic clamping time) with comparable results. the technique of translocation of secondary chordae essentially consists of three stages: 1. selection of the secondary chordae. 2. fixation of secondary chordae to the free edge of the valve. 3. annuloplasty support ring and hydraulic test to confirm the absence of prolapse.

Eligibility criteria:
inclusion criteria: 1. isolated type ii mitral valve insufficiency by a. carpentier 2. mitral regurgitation degree \>2 3. age \>18 years 4. signed informed consent to participate in the study exclusion criteria: 1. any other cardiac surgeries 2. age \<18 years 3. multiple organ failure 4. redo procedure 5. persistent atrial fibrillation 6. acute infective endocarditis 7. refusal to sign informed consent

Keywords: mitral valve chordae degenerative mitral valve disease mitral valve chordae replacement mitral valve chordae translocation mitral valve chordae prosthetics
some biomarkers in bronchial asthma in children

Conditions: Bronchial Asthma

Summary: asthma, a disease characterized by chronic airway inflammation and hyper -responsiveness, is a common disease that affects all age groups. asthma may be manifested as irreversible airflow obstruction in some patients. although the pathogenesis of asthma is not well understood, increased oxidative stress due to an imbalance of oxidants and antioxidants has been found to be associated with asthma. in asthma, inflammation-related oxidative stress is driven by exposure to a variety of triggers, including allergens and viruses, which activate components of both the innate and acquired immune responses. protection by escaping from triggering factors or standardization of asthma medication is difficult and usually is not enough for effective treatment. on the other hand, correction of antioxidative systems may be more efficacious in the control of asthmatic inflammation and asthma symptoms. little is known about the role of asymmetric dimethylarginine in the pathogenesis of asthmatic airway inflammation. the lung is a major source of asymmetric dimethylarginine that can promote oxidative stress by a reduction in nitric oxide synthesis which would result in higher levels of peroxynitrite, that causes oxidative cell damage, and exacerbate airway inflammation. asymmetric dimethylarginine can modify lung function, increase airway hyper-reactivity even in non-inflamed airways, and promote lung collagen production and deposition. increased asymmetric dimethylarginine in serum has been found to be associated with the severity of symptoms of asthma in obese adults. malondialdehyde is an oxidant marker of pulmonary oxidative stress, and lipid peroxidation. paraoxonase, an antioxidant enzyme may play a protective role in asthma. it hydrolyzes lipid peroxides and prevents low-density lipoprotein oxidation.


Eligibility criteria:
• all known asthmatic patients aged six years or more who will be regularly attending assuit university children's hospital outpatient clinic. exclusion criteria include * obese children, * the presence of chronic heart, liver and kidney diseases, concomitant chronic inflammatory disease and autoimmune disorders, and diabetes mellitus. * patients taking antioxidant drugs, vitamins, diuretics, hormone replacement therapy will be also excluded. * children aged less than six years. 5-children who have symptoms of lower or upper respiratory tract infection or asthma exacerbation within the previous four weeks.
thrombolysis and ripc in acute ischemic stroke

Conditions: Acute Ischemic Stroke, Cerebral Embolism and Thrombosis

Summary: remote ischemic postconditioning (ripc) is suggested to protect the cerebral cell against ischemia in various settings. however, the effect of ripc in patients with acute ischemic stroke who undergo thrombolysis has yet to be examined. in this single-center, randomized controlled trial, we examined the effect of ripc on the resolution of nerve function deficient in response to thrombolysis. patients in the ripc group had five cycles of 5-min cuff inflation followed by 3-min deflation to the bilateral upper arm after thrombolysis. the primary endpoint was the recovery of nerve function deficient assessed by national institutes of health stroke scale(nihss), activities of daily living(adl), modified rankin scale(mrs), ct cerebral perfusion imaging (ctp) and ct angiography(cta). secondary endpoints included the following: angiogenesis assessed by the level of vascular endothelial growth factor (vegf), basic fibroblast growth factor (bfgf).


Eligibility criteria:
inclusion criteria: * in accordance with the guideline of thrombolysis in acute ischemic stroke and accomplish intravenous thrombolytic therapy using alteplase; * the consciousness of patients are conscious,somnolence,confusion and stupor，can comply better with the ripc treatment; * acute ischemic stroke confirmed by cranial ct/mri; * provision of written informed consent. exclusion criteria: * history of cerebral embolism,cerebral hemorrhage, brain tumor, brain trauma or other brain lesion; * severe cardiac, liver, or kidney disease, malignancy, systemic organ dysfunction; * blood pressure \ 200/110 mmhg after treatment; * dementia or mental illness; * history of major surgery or trauma 4 weeks prior to admission; * failure to provide informed consent.
effect of photobiomodulation on ph and salivary flow

Conditions: Xerostomia

Summary: changes in salivary parameters, such as decreased flow, changes in ph and composition, can lead to changes in oral health. saliva is responsible for the homeostasis of the oral cavity and is therefore directly related to the occurrence of caries, periodontitis, fungal and bacterial infections. these situations compromise the quality of life of the population and for this reason prevention and treatment strategies need to be studied and developed. photobiomodulation is an alternative that has been increasingly practiced by health professionals. it consists of the application of light to a biological system that is capable of inducing a photochemical process, mainly in the mitochondria, thus stimulating the production of energy in the form of adenosine triphosphate (atp), which can increase cellular metabolism and produce effects. as analgesia and tissue regeneration. in dentistry, studies using photobiomodulation have shown promise in improving some salivary parameters. this study aimed to compare the action of infrared light on salivary flow and ph, using two application techniques: extraoral (g1) and intra and extraoral (g2), with the application interval between the two techniques being 7 days

this is a quasi-experimental clinical study evaluating the flow and salivary ph of healthy adults. the study was carried out with 20 adult patients at the nove de julho university. this study aimed to compare the action of infrared light on salivary flow and ph, using two application techniques: extraoral (g1) and intra and extraoral (g2), with the application interval between the two techniques being 7 days. the sample consisted of 20 healthy adults, who participated in both groups, thus being the actual control in the evaluations. stimulated saliva was collected in both groups before and immediately after light application. in g1, a cluster with 3 spots was used, at a wavelength of 808 nanometers, power of 120 mw, with 24j of energy on the extraoral surface, for 67 seconds, in the region of the parotid gland, region of the submandibular and sublingual glands bilaterally, totaling 4 application regions, with total deposited energy of 96 joules. in g2, the laser was applied for 60 seconds, in 2 intraoral and 2 extraoral points in the region of the parotid glands bilaterally, as well as 1 intraoral and 1 extraoral point in the regions of the submandibular and sublingual glands (totaling 16 points), with a central wavelength of 808 nm; continuous operating mode; power of 100mw; with an aperture diameter of 0.354 cm (with spacer); radiant energy of 6j per point, totaling 96 joules of energy.

Eligibility criteria:
inclusion criteria: * healthy adults over 18 years of age * healthy dentition. exclusion criteria: * dental caries * gingivitis or other alterations in the oral cavity * who use medication that has the side effect of decreasing the salivary flow, * who have used an antibiotic or anti-inflammatory within the last 30 days, * diabetes.

Keywords: saliva flow photobiomodulation
tele-rehabilitation intervention in community-based healthcare for patients with parkinson's disease (dheal-com-pd)

Conditions: Parkinson Disease; Older People

Summary: the study aims to measure the improvement in functional capacity in a group of elderly people suffering from early-stage parkinson's disease (hoehn \& yahr scale 1-3), following a telerehabilitation intervention integrated with bts telerehab technology.

the dheal-com-pd project aims to evaluate the improvement in physical performance of parkinson's disease patients following an integrated rehabilitation intervention with technology in telerehabilitation. in fact, the project involves the administration of a rehabilitation intervention in telerehabilitation integrated with bts telerehab technology, which is able to recognize the patient's movements and analyze them according to quantitative (repetitions) and qualitative (postural and balance)-indicators. the trial is a feasibility study, with single-blind randomized controlled trial type experimental design. forty older adults with parkinson's disease will be recruited for the study and randomized into two groups: the experimental group, that will perform tele-rehabilitation at home with a non-immersive virtual reality system, and the control group. patients in the control group will be offered activities to perform at home, with the same frequency, in line with the usual care activities already proposed by the rehabilitation unit.

Eligibility criteria:
inclusion criteria: * suffering from parkinson's disease: hoehn \& yahr stage i-iii; * functional ambulation category (fac) score ≥ 3; * stability of drug treatment for at least 1 month; * maintaining an upright position independently \> 30"; * no acute or untreated health problems; * mini mental state examination (mmse) ≥ 24; * geriatric depression score (gds) \< 2; exclusion criteria: * myocardial infarction or stroke within 6 months; * painful arthritis, spinal stenosis, amputation, painful foot lesions, or neuropathy that limits balance and mobility; * uncontrolled hypertension * metastatic cancer or immunosuppressive therapy; * significant visual or hearing impairment.
developing and testing a self-compassion tool kit to improve the care of individuals with type 2 diabetes

Conditions: Type 2 Diabetes; Diabetes Distress

Summary: there is a high prevalence of anxiety and depression in patients with type 2 diabetes (t2d). while past studies demonstrate the potential therapeutic effect of mindfulness-based interventions in patients with t2d, little is understood about the mode of delivery or quantity of the intervention necessary to experience benefits. this project aims to develop and implement a self-compassion tool kit based on the principles of mindfulness and meditation to better understand how self-compassion works to affect psychological health and wellbeing in patients with t2d. the investigators will study the impact of a self-compassion tool kit - including mindfulness meditation, exercise, journaling and sleep parameters - on t2d. enhancing emotional well-being could complement current t2d treatments to facilitate improved quality of life.

a pre-test and post-test experimental design will be used to evaluate the efficacy of the self-compassion tool kit on distress, coping, testing glucose, sleep, and wellness in adults living with t2d. for this 4-week study, participants will receive education on sleep hygiene practices during the first week of the intervention. mindfulness meditation will be offered to participants using the headspace app and four, ten-minute sessions will be prescribed per week. for exercise, 30-60 minutes of daily physical activity will be prescribed and participants can select the exercise of their choice. additionally, participants will receive a journal in the mail with prompts associated with each day of required journalling. prompts will elicit reflections, gratitude and growth. participants will be followed by telephone every week. baseline and week four data will be collected using the demographic form, t2ddas, the pittsburgh sleep quality index (psqi) and the sf-20. in addition, participants will be instructed to maintain a glucose testing, meditation, and exercise adherence log. the glucose testing log will permit measuring consistency and adherence to treatment over the course of the study.

Eligibility criteria:
inclusion criteria: * has type 2 diabetes * has a score above 2 on the t2d distress assessment scale exclusion criteria: * does not have type 2 diabetes * has a score above 2 on the t2d distress assessment scale * cannot safely exercise * cannot complete the requested tasks
amelogenins and systemic inflammation after periodontal surgical therapy

Conditions: Periodontal Diseases

Summary: the aim of this study is to compare surgical treatment of periodontal infrabony defects with and without the adjunct of an enemal matrix derivative (emd) in terms of acute-phase responses, in systemic healthy patients.


Eligibility criteria:
inclusion criteria: * good health * no previous periodontal surgical treatment * indication for periodontal surgery (intrabony defects to be at least 4 mm deep) * ability to understand the study procedures and comply with them through the length of the study exclusion criteria: * pregnancy, breast feeding or taking oral contraceptive (all non-drug contraceptives will be allowed) * the need for antibiotic therapy to undergo periodontal therapy * chronic infections * systemic diseases * patients who report current smoking over 20 cigarettes per day or pipe or cigar
retrospective study on caplacizumab-treated pediatric patients with immune-mediated thrombocytopenic purpura (ittp)

Conditions: Immune-mediated Thrombocytopenic Purpura

Summary: the purpose of this multi-country, retrospective data collection study (chart review) is to describe the effectiveness and safety of caplacizumab in pediatric patients with ittp.

pediatric patients who received caplacizumab will be identified for enrollment in the chart review. the eligibility period starts on august 30, 2018 in the united kingdom (uk) and france and february 6, 2019 for the united states (us). data collection is fully retrospective and will be anchored to the patient's index event date. the index event date is defined as the date the patient initiated caplacizumab treatment. the study period begins at the index date and ends at the earliest date of chart abstraction initiation, 12 weeks after last dose of caplacizumab treatment, date of death, or loss to follow-upwhich ever comes first .

Eligibility criteria:
inclusion criteria: * patient's aged ≤18 years at start of caplacizumab treatment initiation * patient has a diagnosis of ittp documented in the medical records * patient was treated with caplacizumab within the eligibility period exclusion criteria: * patient declined use of data for study (where local regulations require patient notification of planned study) * patient's medical chart is missing or not retrievable
antioxidant supplement associated with oral probiotics in patients with pcos in ivf

Conditions: Infertility, Female; Polycystic Ovary Syndrome

Summary: the aim of the study is to study the effect of an antioxidant food supplement associated with probiotics on the oocyte quality response, oxidative stress and microbiota function in an in vitro fertilization cycle in patients with polycystic ovarian syndrome

after being informed about the study, all patients meeting the inclusion/exclusion criteria and giving written informed consent will be randomized in a double-blind manner in a ratio 1:1 to receive the antioxidant supplementation associated with probiotics (myo-inositol, d-chiro-inositol, folic acid, selenium, vitamin d, melatonin, lactobacillus rhamnosus, lactobacillus cripatus and lactobacillus plantarum) or placebo (folic acid) once daily.

Eligibility criteria:
inclusion criteria: * age:18-38 years old * diagnosis of pcos according to compliance with the rotterdam criteria * bmi \>= 25 exclusion criteria: * hormonal contraceptive, insulin sensitizers such as metformin, inositols, antioxidants, vitamin supplements except folic acid, gnrh analogs, steroidal drugs or others with anti-inflammatory properties, antibiotics, probiotics, laxatives use in the 3 months prior to recruitment * tobacco consumption in last 12 months * endometriosis, hydrosalpinx not surgically treated, acute or chronic inflammatory diseases, systemic immune diseases, other endocrine diseases or dysfunctions except for pcos and subclinical hypothyroidism treated with low doses of levothyroxine (eg congenital adrenal hyperplasia, cushing's syndrome, androgen-secreting tumors, diabetes millitus, hyperprolactinemia, hyperglycemia), active neoplastic disease or without evidence of complete remission for at least 5 years, * active participation in an active weight reduction program or hypocaloric diet during the study period. no change in habits will be taught during the study period * hypersensitivity to any of the components in the fertybiotic mujer plus® formulation
using shear wave ultrasound elastography for follow up after anti-spastic intervention among stroke patients

Conditions: Stroke; Spasticity, Muscle; Botulism; Ultrasound; Activity of Daily Living

Summary: spasticity of stroke patient, a very common complication in clinical practice, affects performance of hand function and gait pattern. it also interferes with quality of life of patients severely. currently first line clinical approach to spasticity consist of physical therapy and pharmacological management. however, there are still some refractory cases that needed local intervention such as botox injection. so far, we only can use subjective methods to measure muscle tension, such as modified ashworth scale and tone assessment scale. in our previous study, we found that ultrasound shear wave image could correlate with muscle stiffness caused by poststroke spasticity. with this new method, we aim to establish a more objective method in measuring abnormal poststroke muscle tension before and after treatments and further monitor therapeutic effect. we also include several assessment scales to evaluate the correlation between measured muscle spasm and activity of daily living. we hypothesize that the rheological changes in muscles muscle spasm after botox injection can be detected by ultrasound shear wave image. therapeutic effect can also be seen in its effect on daily functions. in this project, we will use shear wave imaging of ultrasound to investigate the elasticity (and hardness) of the biceps brachii and brachialis muscle in stroke patients with unilateral hemiplegia before and after botox injection. the findings of this project will provide the objective evaluation of muscle spasticity and its correlation with functional status, which will provide new points of view toward treatment of spasticity.


Eligibility criteria:
inclusion criteria: \[intervention group\] * stroke patients with unilateral involvement * patient's spasticity over affected upper extremities scored at least 1+ with modified ashworth scale * patient required botulinum toxin injection at affected upper limb muscle per primary care physician. \[control group\] * stroke patients with unilateral involvement * patient's spasticity over affected upper extremities scored at least 1+ with modified ashworth scale exclusion criteria: * patients ever diagnosed with cerebral diseases other than stroke, such as traumatic brain injury, encephalitis and brain tumor * patients failed to cooperated due to cognition, consciousness or speech problem * patients with illness that could affect muscle stiffness, such as spinal cord injury and parkinson's disease * patients with upper limb contracture * patients receiving botulinum toxin injection or shock wave therapy over upper extremities during past three months