Kornimate/medical-research-clean huggingface dataset:
a randomized controlled study of prolonging the time of progesterone supplementation to improve the pregnancy outcome of single day 6 blastocyst transfer of freeze-thaw cycle

Conditions: Infertility

Summary: this is a single-center, prospective, randomized controlled study. patients with single blastocyst transfer in the freeze-thaw cycle, aged from 20 to 38 years, with less than three transfers, and with hrt-cycle single d6 blastocyst transfer in the current cycle were enrolled as the study participants. they were randomized into two groups using an excel table, and the efficacy was evaluated in a blinded manner by a third party who was unaware of the grouping; the data summary phase was performed by blinded statistical analysis with triple separation of the investigator, operator, and statistician.


Eligibility criteria:
inclusion criteria: 1. aged 20 to 38 years. 2. less than three transfers. 3. undergoing hrt freeze-thaw cycle single blastocyst transfer in the current cycle. 4. having consented to participate in this study and signed the informed consent form. exclusion criteria: 1. chromosomal abnormality in either the patient or their partner 2. contraindications to hormone replacement therapy. 3. patients with intramural myoma affecting the morphology of the uterine cavity, severe adenomyosis, endometriosis, congenital uterine anomalies, endometrial tuberculosis, intrauterine adhesion and other diseases significantly affecting embryonic implantation. 4. currently participating in another clinical study.
effects of swedish massage prior circuit breathing training on asthma

Conditions: Asthma; Status

Summary: the objective of this study was to determine the effects of swedish massage prior circuit breathing training on asthma control and respiratory function in patients with asthma.

thirty patients with asthma aged 20-65 years were randomized into 3 groups: the control group (con; n=10), the circuit breathing training group (cbt; n=10), and the swedish massage prior to circuit breathing training group (sbt; n=10). participants in the con group carried out their daily routine without receiving any training program. the cbt group received circuit breathing training sessions lasting thirty minutes each, three times a week for twelve weeks, while the sbt group received a swedish massage (20 minutes) before circuit breathing exercises (30 minutes) three times a week for twelve weeks. physiological data, pulmonary function, respiratory muscle strength, cytokine levels, asthma control test scores, visual analogue scale scores, chest expansion, and muscle flexibility variables were analyzed during the pre-test, post-test at 6 weeks, and post-tests at 12 weeks. two-way repeated measures anova was used to compare the variables between each test and between groups. statistical significance was defined as p \< .05.

Eligibility criteria:
inclusion criteria: * being a male or female patient with asthma who is between 20 and 65 years old. * being a patient who has been diagnosed by a doctor with asthma for at least 6 months. * the severity of the disease has been assessed at levels 2 to 4, meaning the volume of air expelled in the first second of breathing quickly and with full force (forced expiratory volume in one second; fev1) is between 80% and 30% on the date of data collection. this has been certified by a doctor, and the patient is using medication according to the normal treatment plan. * must not have other respiratory diseases such as tuberculosis, lung cancer, emphysema, chronic obstructive pulmonary disease (copd), etc. * should not have received exercise training for more than 20 minutes at a time, 3 days/week, or more in the past 6 months before participating in the research. * having no communication problems. * the sample volunteers to participate in the research and agrees to sign the consent form to participate in the research. exclusion criteria: * being a patient who has a history of asthma caused by exercise (exercise-induced asthma). * in case of a force majeure event that makes it impossible to continue participating in the research, such as injury from an accident or illness, etc. * participating in less than 80 percent of the training sessions (28 times out of 36 times) for the breathing training group and the group that practiced breathing together with massage. * unwillingness to continue participating in the research.

Keywords: asthma circuit breathing swedish massage pulmonary function asthma control
a study of the safety and efficacy of ciclesonide in the treatment of non-hospitalized covid-19 patients

Conditions: COVID-19

Summary: the purpose of this study is to assess the safety and efficacy of alvesco (ciclesonide) inhalation aerosol in non hospitalized patients with symptomatic covid-19 infection in a multicenter, randomized, double-blind, placebo controlled study

this is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, efficacy, and safety study of ciclesonide mdi for the treatment of symptomatic covid-19 infection. enrolled patients were male and female adults and adolescents 12 years of age or older with confirmed covid-19 infection who were currently exhibiting symptoms of the disease and who were not currently hospitalized or under immediate consideration for hospitalization at the time of enrollment. the study consisted of an initial screening/enrollment/randomization visit, a 30-day treatment period, and a follow-up period.

Eligibility criteria:
inclusion criteria patients eligible for enrollment in the study must meet all the following criteria: 1. male and female adults and adolescents (12 years of age and above). 2. positive sars-cov-2 rapid molecular diagnostic test within 72 hours prior to enrollment. 3. patient is not currently hospitalized or under immediate consideration for hospitalization at the time of enrollment. 4. patient is currently experiencing symptoms of fever, cough, and/or dyspnea. 5. patient has an oxygen saturation level greater than 93%. 6. ability to show adequate use of mdi, including inhalation technique. 7. patient, parent/legal guardian, or legally-authorized representative must have signed a written informed consent before administration of any study-specific procedures. exclusion criteria patients meeting any of the following criteria are not eligible for participation in the study: 1. existence of any life-threatening co-morbidity or any other medical condition which, in the opinion of the investigator, makes the patient unsuitable for inclusion. 2. history of hypersensitivity to ciclesonide. 3. treatment with inhaled or intranasal corticosteroids within 14 days of the screening/ enrollment/randomization visit. 4. treatment with oral corticosteroids within 90 days of the screening/enrollment/randomization visit. 5. participation in any other clinical trial or use of any investigational agent within 30 days of the screening/enrollment/randomization visit. 6. currently receiving treatment with hydroxychloroquine/chloroquine. 7. patients with cystic fibrosis. 8. patients with idiopathic pulmonary fibrosis.
chlorhexidine versus n-asetil sistein irrigation in mandibular molar teeth with chronic apical periodontitis

Conditions: Chronic Apical Periodontitis

Summary: the goal of this clinical study was to evaluate the effect of using different irrigation solutions in the final irrigation of root canal treatment procedures on the intensity of postoperative pain and periapical tissue healing in patients presenting with mandibular molars with chronic apical periodontitis. the main question it aims to answer is: - does controlled irrigation with chlorhexidin and n-asetil sistein in root canal treatment reduce the severity of postoperative pain? in the chlorhexidin group, unlike the control group, each root canal was irrigated with 3 ml %2 chlorhexidin solution in the final irrigation. in the n-asetil sistein group, unlike the control group, each root canal was irrigated with 3 ml 200 mg/ml n-asetil sistein solution in the final irrigation.


Eligibility criteria:
inclusion criteria: * mandibular permanent molars with chronic apical periodontitis * teeth with periapical index (pai) score greater than 2 * teeth with periodontal pocket depth less than 3 mm * patients without systemic disease (asa 1-2) exclusion criteria: * patients who have used analgesic, anti-inflammatory or opioid drugs in the last 7 days or antibiotics in the last 3 months * patients who report pregnancy, lactation or psychiatric disorders * teeth with a history of root canal treatment, sinus tract or abscess, and teeth planned for prosthetic restoration

Keywords: chronic apical periodontitis postoperative pain n-asetil sistemin chlorhexidin
effects of narrative writing duration and post-writing processing instructions on ptsd

Conditions: Posttraumatic Stress Disorder (PTSD)

Summary: the current study proposes to directly measure how processing after participating in written disclosure about a traumatic life event affects physical and psychological outcomes.

previous research has established the potential for narrative writing about traumatic events to result in positive benefits for physical and psychological health. research has also provided evidence that written disclosure may reduce post-traumatic stress disorder (ptsd) symptoms. several mechanisms of action have been proposed to explain why written disclosure produces positive benefits, but all have focused on processes occurring during the writing session. it has been suggested, however, that additional processing may occur after the writing exercises are over, yet no research has studied the influence of this processing on outcomes. the current study proposes to directly measure how processing after participating in written disclosure affects physical and psychological outcomes.

Eligibility criteria:
inclusion criteria: * experienced a traumatic life event (dsm-iv-tr criterion a) * currently experiencing clinically significant levels of ptsd symptoms exclusion criteria: * currently receiving psychotherapy * on medication that is not stable (i.e. medication has been changed within the past 6 weeks)

Keywords: posttraumatic stress disorder (ptsd) narrative writing
surgical decision making among people with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: this is a study for people with inflammatory bowel disease ("ibd"--that is, ulcerative colitis, crohn's colitis, or indeterminate colitis). we are studying how people with ibd decide to have surgery when a doctor has told them they should think about having their colon (large bowel) removed. this surgery is called a "colectomy." patients will be asked to fill out a questionnaire that takes about 60 to 90 minutes to complete. questions ask about patients' background (age, etc.) and their ibd. they also ask about patients' decision to have surgery or not to have surgery. for instance, what kinds of things did they think about? some questions ask about other people who affected the choice and how patients felt about the help they got from others. people who wish to join the study will receive payment to thank them for their time. * patients must be at least 18 years old * patients must speak english * patients must have been told by their doctor to think about having surgery to take out their colon to (a) lower their risk for cancer or (b) because they have pre-cancer (called "dysplasia") * patients do not need to have had the surgery--they may have already had the surgery, they may not have had it yet, or they may have decided they do not want to have it


Eligibility criteria:
inclusion criteria: 1. have been told by a doctor that they have ulcerative colitis, crohn's disease, or indeterminate colitis. 2. be at least 18 years old 3. speak english 4. have been told by a doctor to think about having surgery to take out their colon ("colectomy") within the last 3 years
using of ice cream for diagnosis of diabetes mellitus

Conditions: Diabetes Mellitus

Summary: the overall global prevalence of type 2 diabetes mellitus (dm) is rising. based on the latest thai national health examination survey, an estimated 3.2 million people had dm, of whom one-third was undiagnosed. the inexpensive oral glucose tolerance test (ogtt) is a more sensitive and reliable test of dm than fasting plasma glucose (fpg) or hba1c, and is recommended for diagnosing dm and impaired glucose tolerance (igt). although the ogtt provides useful diagnostic information, poor patient tolerance of glucose solutions is inevitable.

regarding the diagnosis of dm, oral glucose tolerance test (ogtt) identifies about 2% more individuals than does fasting plasma glucose (fpg). hence ogtt is the method that has high sensitivity compared to other methods for diagnosis of igt (impaired glucose tolerance) and diabetes. however, standard ogtt with 75-g glucose has poor patient tolerance and might cause reactive hypoglycemia. the alternatives for 75-g glucose would help for screening of dm with better tolerance. there were previous studies investigated substitutes for oral glucose solution with cookies and muffin. in the present study we hypothesized that an alternative food such as ice cream, a favorite dessert, can use for evaluation of the diagnosis of dm and igt instead of standard 75-g glucose.

Eligibility criteria:
inclusion criteria: * healthy volunteer * agree to participate by written informed consent exclusion criteria: * previous history of diabetes mellitus * pregnant woman * hospitalised patients * underlying disease of liver and kidney disease * who take any medications that interfere with plasma glucose levels such as steroid
the influence of food for special dietary use - spread enriched with 5-hydroxytryptophan, theanine and gamma-aminobutyric acid on psychophysiological functions of subjects without meaningful organic and cognitive pathology

Conditions: Cognitive Change; Memory; Disturbance, Mild; Emotional Regulation; Concentration Ability Impaired

Summary: this is a single-centre, single-blind, two-arms, controlled study to assess the efficacy and safety of food for special dietary use enriched with 5-hydroxytryptophan, l-theanine and gamma-aminobutyric acid in generally healthy subjects with no cognitive disturbances


Eligibility criteria:
inclusion criteria: * willingness to participate; * age of 18-50 years exclusion criteria: * pregnancy or breastfeeding; * significant somatic or psychological disorders
comparison of stabilization exercises versus thrust manipulation technique on pelvic girdle pain.

Conditions: Pelvic Girdle Pain

Summary: the objective of this research is to compare the efficacy of stabilization exercise versus pelvic girdle pain thrust manipulation technique in females with postpartum pain.

pelvic-girdle pain is a mechanical disorder growing rapidly as a consequence of changing delivery pattern and changing lifestyle. medication with synthetic drugs not only has been unable to effectively curtail the spread of this disease conditions but also is most of the times linked with co-occurring side-effects. the exercise and manual therapy-based approach could lead in reducing the functional limitations and morbidity rate in females with the postpartum pain. this research could also help in spreading the awareness globally, to prenatal and postnatal hospital caregivers.

Eligibility criteria:
inclusion criteria: * • post-partum females with the normal vaginal delivery present with pelvic girdle pain before the next conception. * aged between 18 and 45 * posterior pelvic girdle pain located distal and/or lateral to the l5-s1 * pain onset during pregnancy or within 3 weeks after delivery, most recent delivery within 6 to 16 weeks * positive posterior pelvic pain provocation (p4) test exclusion criteria: * patients presenting with the history of: * back pain indicating radiculopathy * mechanical back pain * back pain due to disc herniation * rheumatological diseases * neurological illness or recent surgery * women who have gone through c-section
a study to compare taspoglutide and insulin glargine in insulin-naïve patients with type 2 diabetes mellitus inadequately controlled on metformin and sulfonylurea combination therapy

Conditions: Diabetes Mellitus Type 2

Summary: this randomized, open-label, parallel arm study will compare the safety, tolerability and effect on glycemic control of taspoglutide versus insulin glargine in insulin-naïve patients with type 2 diabetes mellitus inadequately controlled on merformin and sulfonylurea combination therapy. patients will be randomized to receive either taspoglutide 10mg subcutaneously (sc) weekly, or taspoglutide 10mg sc weekly for 4 weeks followed by 20mg sc weekly, or insulin glargine at an initial dose of 10 international units sc daily. metformin treatment will be continued in all patients throughout the study, whereas sulfonylurea will be discontinued before starting study treatment. anticipated time on study treatment is 24 weeks, with an option to continue the assigned treatment for another 28 weeks. target sample size is 500-600 patients.


Eligibility criteria:
inclusion criteria: * adult patients, 18-75 years of age * type 2 diabetes mellitus, treated with stable dose of metformin and sulfonylurea for \>/= 12 weeks prior to screening * hba1c 7-10% at screening * body weight stable (+/-5%) for \>/= 12 weeks prior to screening * fasting c-peptide \>/=1ng/ml * treatment-naïve for insulin exclusion criteria: * diagnosis or history of type 1 diabetes mellitus or secondary forms of diabetes * acute metabolic diabetic complications or evidence of clinically significant diabetic complications * clinically symptomatic gastrointestinal disease * history of chronic pancreatitis or acute idiopathic pancreatitis * \>3 episodes of severe hypoglycemia within 6 months prior to screening * miocardial infarcion, unstable angina pectoris, coronary artery bypass surgery, post-transplantation cardiomyopathy or stroke within 6 months prior to screening * any treatment with exenatide, exendin analogues, glp-1 or its analogues
effect of premedication on success of inferior alveolar nerve block injection

Conditions: Irreversible Pulpitis

Summary: the aim of this study is effect of premedication on success of inferior alveolar nerve block injection. sixty healthy adult volunteers including criteria, are participating. the patients will be divided into 3 groups and will be randomly given one of premedications including 1) 10 mg ketorolac, 2) 10 mg ketorolac plus 1000mg acetaminophen, and 3)placebo, 45 minutes before applying the injection. all patients will receive standard inferior alveolar nerve block injection . patients with no lip numbness and positive responses to cold and electric pulp tests would be excluded from the study. endodontic access preparation will be initiated 15 minutes after inferior alveolar nerve block injection. pain during treatment will be recorded using a heft parker visual analog scale(vas). success will be considered as no or mild pain (vas≤54) during caries/dentin removal, access cavity preparation and working lengths measurements. data will be analysed using mann-u-whitney and kruskal-wallis tests.

the aim of this study is effect of premedication on success of inferior alveolar nerve block injection. sixty healthy adult volunteers with including criteria and with no spontaneous pain, reporting no or mild (visual analog scale≤54) pain in response to cold testing and electric pulp tester, are participating. the patients will be divided into 3 groups on a random basis and will be randomly given one of the oral medications including 1) 10 mg ketorolac, 2) 10 mg ketorolac plus 1000mg acetaminophen, and 3)placebo, 45 minutes before applying the injection. all patients will receive standard inferior alveolar nerve block injection with one carpule of 4% articaine with 1:100000 epinephrine. patients with no anesthetic sign (lip numbness) and positive responses to cold and electric pulp tests would be excluded from the study. endodontic access preparation will be initiated 15 minutes after inferior alveolar nerve block injection. pain during treatment will be recorded using a heft parker visual analog scale(vas). success will be considered as no or mild pain (vas≤54) during caries/dentin removal, access cavity preparation and working lengths measurements. data will be analysed using mann-u-whitney and kruskal-wallis tests.

Eligibility criteria:
inclusion criteria: * patients with age ranged 18-65 * without systemic diseases * without any medicine consumption * non smoking * non pregnant * non breast feeding * with asymptomatic irreversible pulpitis ( visual analog scale ≤ 54) in one mandibular molar that needs root canal treatment * without any medicine consumption or analgesic and sedation * understand and sign the vas and consent forms exclusion criteria: -

Keywords: failure injection ketorolac premedication
assessment of neonatal hyperbilirubinemia by neopredix b.1 algorithm

Conditions: Newborn Jaundice

Summary: due to actual standard of neonatal care bilirubin is monitored in neonates several times after birth to avoid hyperbilirubinemia. as the peak is often one or two days after discharge from hospital a more precise predication than the actual one is desirable to avoid needlessly follow-ups. the precision of an algorithm to predict bilirubin values 24-48h into the future is evaluated in this study.

neonatal jaundice is common and mostly transient without need for intervention. to identify infants at risk of bilirubin toxicity, bilirubin is measured several times after birth and before discharge home. as the peak bilirubin concentrations are reached at days 4-6 after birth, and most infants are discharged home around 48 hours after birth, parents are often asked to return to hospital one or two days after discharge with their newborn baby to have the bilirubin value checked in order to prevent that hyperbilirubinemia requiring treatment is not missed. a precise prediction of the course of bilirubin values based on the measurements done during the initial hospital stay after birth would be desirable to avoid unnecessary follow ups (both for the families and the health care system). this study aims to evaluate the precision of the neopredix b1 algorithm. this algorithm predicts bilirubin values 24-48h into the future based on preceding values and some clinical variables. five different scenarios will be explored, differing in the type, number and timepoints of measurements used for the prediction as well as the timepoint that is to be predicted.

Eligibility criteria:
inclusion criteria: * newborn infant * gestational age at birth ≥ 34+0/7 weeks exclusion criteria: * birth weight \< 1500g * gestational age at birth \> 42+6/7 weeks * genetically defined syndrome * severe congenital malformation adversely affecting life expectancy or admission for a priori planned palliative care * parents not fluent in german

Keywords: newborn jaundice hyperbilirubinaemia