Kornimate/medical-research-clean huggingface dataset:
effects of exercise trainings on pain, function and ahd in patients with sps

Conditions: Subacromial Impingement Syndrome

Summary: abnormal reduction of the ahd has been considered as one of the possible mechanisms in the aetiology of subacromial pain syndrome. maintenance of the ahd is crucial for prevention and rehabilitation of rotator cuff related disorders. the development of a rehabilitation treatment plan is based in part on the assessment of scapular motion and muscle deficits in patients with shoulder pain. rehabilitation should be based on the identified impairments. the aim of this study is to investigate the effect of utilizing scapula retraction exercises with or without glenohumeral rotational exercises at gradual shoulder elevation angles into a scapular stabilization program on functionality, pain and ahd in patients with sps and compare with health population.

coordinated motion between the humerus and scapula is required for pain-free arm movement. rotator cuff and scapulothoracic muscles dynamically control the subacromial space or acromiohumeral distance (ahd).scapulothoracic muscles need to provide stability and control in a synchronized fashion to facilitate normal scapulohumeral movement. scapular upward rotation and posterior tilt is essential to maintain the ahd.therefore, the force couple function of the rotator cuff muscles play an critical role in opposing the superior migration force that is generated by deltoid muscle and, to maintenance the subacromial space. abnormal reduction of the ahd has been considered as one of the possible mechanisms in the aetiology of subacromial impingement syndrome. maintenance of the ahd is crucial for prevention and rehabilitation of rotator cuff related disorders. the development of a rehabilitation treatment plan is based in part on the assessment of scapular motion and muscle deficits in patients with shoulder pain. rehabilitation should be based on the identified impairments. he aim of this study is to investigate the effect of utilizing scapula retraction exercises with or without glenohumeral rotational exercises at gradual shoulder elevation angles into a scapular stabilization program on functionality, pain and ahd in patients with sps and compare with health population.

Eligibility criteria:
inclusion criteria: * painful arc of movement during flexion or abduction; * positive neer or kennedy-hawkins impingement signs * pain on resisted lateral rotation, abduction or empty can test. exclusion criteria: * previous shoulder surgery; * shoulder pain reproduced by neck movement; * clinical signs of full-thickness rc tears; or * shoulder capsulitis.

Keywords: acromiohumeral distance pain functional level subacromial impingement syndrome
sofia strep a fia field study

Conditions: Group A Streptococcus; Strep Throat

Summary: the purpose of this study is to demonstrate the ability of the sofia strep a fia test and sofia analyzer to accurately detect a throat swab specimen for the presence or absence of group a streptococcus when compared to culture.


Eligibility criteria:
inclusion criteria: * presence of sore throat * redness of the posterior pharyngeal wall * tonsillar exudate * tonsillar swelling * tender anterior cervical adenopathy * fever, \> 38º c (100.4ºf) at presentation or within past 24 hours other symptoms that may be present, in addition to above symptoms for gas: * rash, typical of scarlet fever * abnormal tympanic membranes * palatal petechiae exclusion criteria: * subjects treated with antibiotics currently or within the previous week (7 days) are not to be included in this study. * at clinical sites requiring informed consent, unable to understand and consent to participation; for minors this includes parent or legal guardian.
fluids affecting bladder urgency and lower urinary symptoms

Conditions: Overactive Bladder; Urinary Urgency; Urinary Bladder, Overactive; Urinary Incontinence, Urge; Caffeine; Alcohol Drinking; Lower Urinary Tract Symptoms

Summary: this study evaluates whether eliminating certain ingredients (caffeine, alcohol, artificial sweeteners, acidic juices) consumed in beverages reduces bladder symptoms of urinary frequency and urgency. women with overactive bladder will be recruited. half of these women will receive instructions to replace beverages containing these ingredients with beverages such as water or milk. the other half of participants will receive instructions on following the united states department of agriculture guidelines on healthy eating.

it is commonly believed that it is better for women's bladders if intake of certain beverages is eliminated. advice is given to women with frequency/urgency symptoms to avoid coffee or tea, sodas or pop, or any other drinks that contain alcohol, caffeine, artificial sweeteners or high acidic content. although the investigators do not know the direct cause and effect of consuming beverages with these ingredients, there might be reduction in "irritating" sensation to toilet often because of urgency if the beverages with these ingredients are replaced by "non-irritating" beverages.

Eligibility criteria:
inclusion criteria: * female * daily intake of at least 16 oz. of potentially irritating beverages, defined as drinks that are caffeinated, artificially sweetened, citric/acidic, or alcoholic beverages * daily intake of at least 32 oz. of total beverages * at least two of the following three qualifications: urinating greater than on average seven times during waking hours on 3-day diary, urinating routinely more than two times at night, answering "yes" to experiencing frequent, strong feelings of urgency to empty the bladder. exclusion criteria: * men * history of diabetes, spinal cord injury, multiple sclerosis, muscular dystrophy, cerebral palsy, dementia or alzheimer's or stroke * currently pregnant or within one year of delivery * currently report symptoms of pain with urination or frequent urinary tract infections * uses diuretic medications, currently taking medication prescribed for bladder symptoms or have had surgery for incontinence with the last 12 months

Keywords: artificial sweeteners caffeine alcohol drinking urinary urgency overactive bladder urinary incontinence, urge lower urinary tract symptoms
effects of windlass versus calcaneal taping in football player with plantar fasciitis.

Conditions: Football Players

Summary: plantar fasciitis is a prevalent ailment that affects the plantar fascia, a dense tissue strip that spans the underside of the foot, from the heel bone to the toes. football players are especially susceptible to this ailment because of the sport's high-impact nature, which includes repetitive sprinting, jumping, and quick changes in direction. taping has been used for many years for various ailments. the purpose of this study is to determine the effects of two taping techniques i.e. windlass taping and calcaneal taping on pain, flexibility and lower extremity function in football players.

the study will be a randomized clinical trial conducted at the pakistan sports board and the raider's football club over a duration of 10 months after synopsis approval. the required sample size for each group, after accounting for a 10% attrition rate, will be 17. two study groups will be established: group a, which will receive calcaneal taping among football players, and group b, which will receive windlass taping among football players. nonprobability purposive sampling will be employed. data will be collected using the numeric pain rating scale (nprs), hubscher maneuver, goniometer, and lower extremity functional scale (lefs) to assess pain severity, flat foot type flexibility, joint range of motion, and lower limb function, respectively. this comprehensive study aims to contribute valuable insights into the effects of calcaneal and windlass taping on football players.

Eligibility criteria:
inclusion criteria: * positive windlass test * pain can appear after a period of intense training, normally declines with the warm up and reappears at the end of training. * intense and acute heel pain localized primarily where plantar fascia attaches to the anterior calcaneus. * the pain presents on first walking in the morning or after a rest period. exclusion criteria: * congenital deformity of ankle and foot. * history of foot and ankle fracture. * history of ankle and foot surgery. * previous surgery or treatment for plantar fasciitis in the previous 6 months. * use of an assistive device for ambulation * use of an assistive device for ambulation * refuse to participate in the study

Keywords: plantar fasciitis taping
combined nerve blockade and local infiltration anesthesia in appendectomy - a blinded randomized study

Conditions: Pain, Postoperative

Summary: the purpose of this study is to assess whether the use of local anesthetic to numb the nerves that run deeper in the abdominal wall gives better post operative pain control than just infiltrating local anesthetic to the wound edges.

local anesthetic is often administered during an operation to reduce post operative wound pain. whilst this is frequently done during an appendectomy there is currently no evidence to suggest whether there is any benefit to the patient to injecting the local anesthetic deeper to block the nerves supplying abdominal wall sensation, compared to using it just in the skin around the wound. comparison: post operative pain scores following appendectomy for patients given skin infiltration of local anesthetic (pre incision), compared to patients given both preincision wound infiltration and deeper field infiltration with local anesthetic(deep to external oblique).

Eligibility criteria:
inclusion criteria: * lanz incision appendectomy as starting procedure, including those where an alternative cause for symptoms is found at operation and those where incision is later extended/changed (these may be sub grouped at time of analysis) * consent obtained exclusion criteria: * laparoscopic appendectomy * appendectomy at time of laparotomy/other incision

Keywords: appendicectomy pain local anaesthetic nerve block post operative pain following appendicectomy
study of human microbiota in healthy and pathological conditions

Conditions: Microbial Colonization

Summary: the aim of the present study is to characterize the bacterial composition (microbiota) colonizing to the human body in different physio - pathological conditions (lifestyle, motor activity, surgical operations, probiotic and prebiotic consumption, antibiotic therapies, chemotherapeutic therapies), nervous and musculoskeletal diseases, gastrointestinal and metabolic disorders , oral and vaginal diseases, etc.). in particular, they will be investigate: * the changes in the bacterial abundance * the potential microbial interactions with the human host * the microbial networks describing on the bacterial interactions within a specific composition of the human microbiota

the main objective of this study is to deepen the knowledge about the bacterial communities associated to the human organism. in particular, the present study aims to evaluate how the microbiota (intestinal, cutaneous, vaginal, nasal, bronchial, breast milk, salivary, oral, etc.) is subject to quantitative and qualitative changes consequently to different events involving the human host. the project trys to highlight which microorganisms may be involved in the onset or progression of certain pathological condition, as well as to identify which bacterial genera can be more subject to variations due to specific non-pathological events. secondary objectives of this study are: * to define a "healthy microbiome", that is to understand which are the main bacteria that commonly compose the human microbiome in physiological conditions, differentiating it from that present in certain pathological conditions. * to characterize the physiological effects that bacterial changes of the human microbiota have on the host. * to evaluate whether the use of probiotics, prebiotics, dietary and nutritional factors, cosmetics, and oral, nasal, vaginal, or pharmacological therapies of any kind can influence the microbial network of the human microbiota associated to different body districts.

Eligibility criteria:
inclusion criteria: * subjects suffering from neurological/behavioral diseases; * subjects suffering of bone diseases; * subjects affected of dysmetabolic / or endocrine disorders; * subjects with physical activities at a competitive level; * subjects affected of gastrointestinal disorders; * subjects with prolonged antibiotic therapies and undergoing surgery exclusion criteria: * no use of probiotics in the month prior the sampling; * no use of antibiotics in the month prior the sampling; * no consumption of yogurt in the month prior the sampling;

Keywords: human microbiota
dy002: safety and effectiveness of dyme as an agent for selective staining of the anterior capsule during cataract surgery

Conditions: Mature Cataracts

Summary: the primary objective of this study is to test the hypothesis that dyme is safe and effective as a drug to facilitate continuous curvilinear capsulorhexis (ccc) by selectively staining the anterior capsule. secondary objectives are to compare the safety and effectiveness of dyme to that of a smaller dose of the same api.


Eligibility criteria:
inclusion criteria: * have a cataract sufficiently opaque/mature/brunescent that, in the surgeon's assessment,a dye could facilitate surgery; * be aged at least 18 years old at the time of enrollment; * be in a medical condition suitable for cataract surgery; * able and willing to participate in study examinations and visit schedule; and * understand and freely consent to participate in the study. exclusion criteria: * in either eye, ocular infection or inflammation within the past 3 months; * known allergy to bbg 250; * uncontrolled intercurrent diseases including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia; * active treatment for cancer or systemic infection within the past month; * active treatment with systemic corticosteroids within the past month; * previous participation in this study for the contralateral eye; * participation in another clinical trial involving an investigational therapeutic during the past 30 days or 5.5 half-lives (if applicable), whichever is longer; * unwillingness to participate in the study or inability to give informed consent; or * any medical condition that in the opinion of the investigator may compromise the research subject's safety or ability to participate in the study.
a prospective case-control clinical study of the ultrasound imaging reporting and data system for diagnosis of anterosuperior acetabular labral tears

Conditions: Acetabular Labrum Tear; Ultrasound Exams; Diagnostic Imaging; Models

Summary: the goal of this clinical trial is to develop an ultrasonic imaging reporting and data system for diagnosis of anterosuperior acetabular labral tears (alt). participants will receive a comprehensive clinical diagnosis or a hip arthroscopy to determine whether there is a torn labrum of the hip. comparing the ultrasonographic characteristics of hip labrum in tear group and non-tear group, establishing diagnostic model is conducive to early diagnosis and differential diagnosis of this disease.


Eligibility criteria:
inclusion criteria: a)18 years of age and above; b) combined with clinical symptoms, signs, and mri, a senior orthopaedic surgeon or a final arthroscopy will determine whether the labrum of the hip is torn. exclusion criteria: a) other diseases affecting the hip joint (tumors, infections and fractures); b) a history of hip surgery; c)bmi≥30 kg/m²; d) pregnant patients.
menthol mouth rinsing and performance responses of elite football referees in the heat

Conditions: Exercise Induced Hyperthermia; Performance Demands of Exercising in the Heat

Summary: ten male football referees will be recruited to perform two intermittent football protocols , separated by at least 7 days (wash-out period). after passing the eligibility criteria, the participants will be randomly assigned, according to a computer-generated allocation schedule, to 1 of 2 beverages sequences: (1) intervention - menthol solution 0.01% (room temperature) and (2) placebo - noncaloric berry-flavoured solution (room temperature). the participants will be provided with one of the 2 beverages before warm-up (pre-cooling) and at the half-time (per-cooling). the trials will follow a randomised counterbalanced crossover design, blinded to the participants, and will take place in indoor facilities, where wbgt exceed 30◦c, at the same time of the day, to control for circadian variations. each trial involves an exercise protocol (saft-90), lasting 90 minutes, separated into two 45-minute parts. the first half will be preceded by a warm-up and the second half by a 15-minute break. the results of this study are expected to determine whether mouth rinsing a menthol solution, before a football exercise protocol performed in the heat, will help to alleviate physiological strain and improve performance parameters, comparing to a non-cooling strategy, in elite male football referees. thus, we can be closer to defining nutritional strategies of internal cooling, that will be an advantage for the performance of the football referees, concretely in the competitions carried out under adverse environmental conditions.


Eligibility criteria:
inclusion criteria: 1. male football referees aged over 18 and under 45 years; 2. with normal weight (bmi ≥ 18.5 and ≤ 24.9 kg/m2); 3. availability to participate in the introductory meeting, familiarization session and 2 experimental sessions; 4. ability to read and sign the informed consent. exclusion criteria: 1. under the influence of any medications that may affect urinary parameters, thermoregulation mechanisms, circulatory system, thyroid and pituitary function or metabolic status; 2. injury, diabetes, autoimmune disease, cardiovascular disease or obstructive disease of the gastrointestinal tract (e.g., diverticulitis, inflammatory bowel disease); 3. schizophrenia, bipolar disorder or other psychotic disorders; 4. eating disorders; 5. mri scans scheduled within 48 hours after familiarization session or any of the experimental trials.
treating basal and squamous cell carcinomas with fractional laser and tirbanibulin ointment

Conditions: Keratinocyte Carcinoma; Basal Cell Carcinomas; Squamous Cell Carcinoma; Skin Cancer

Summary: the investigators seek to evaluate the effectiveness of fractional laser therapy and tirbanibulin ointment to treat squamous and basal cell carcinomas. this will be executed by using both thulium and erbium lasers on previously biopsy-confirmed sccs and bccs and applying bulk heating methods. then, depending on the level of invasiveness, subjects may be instructed to apply the ointment over the course of five nights immediately following the treatment. the intention of this study is to minimize the need for invasive surgical procedures so as to optimize the cosmetic appearance, and provide a treatment option that is beneficial for a wide range of individuals.


Eligibility criteria:
inclusion criteria: biopsy confirmed squamous and/or basal cell carcinoma not previously treated by another method. exclusion criteria: * cannot be pregnant at the time of treatment

Keywords: basal cell carcinoma squamous cell carcinoma bcc scc keratinocyte carcinoma skin cancer laser treatment
assessment of outcomes of double-bundle posterior cruciate ligament reconstruction (db-pclr)

Conditions: Posterior Cruciate Ligament Tear

Summary: double-bundle posterior cruciate ligament reconstruction (db-pclr) is becoming increasingly used alternative to the single-bungle pclr. while more technically challenging, it seems to better improve patients' outcomes. therefore, outcomes of db-pclr will be assessed and reported.


Eligibility criteria:
inclusion criteria: * pcl tear with iii grade sympomatic posterior instability confirmed clinically and radiologically * full knee range of motion exclusion criteria: * active knee inflammation * non-adherence to the study protocol * fixed posterior drawer
[18f]fluoropropyl-trimethoprim ([18f]f-tmp) pet/ct imaging to evaluate biodistribution and kinetics in human subjects

Conditions: Bacterial Infections

Summary: the purpose of this study is to study a radioactive tracer, a type of imaging drug that is injected into the body to see how it is taken up in sites of active infection using an imaging procedure called positron emission tomography/computed tomography (pet/ct).


Eligibility criteria:
inclusion criteria: * at least 18 years of age * known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection) * able to understand the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures exclusion criteria: * antibiotic therapy with trimethoprim within 48h of the baseline pet/ct scan * inability to tolerate imaging procedures, in the opinion of an investigator or treating physician * unstable or other severe medical or psychological comorbidities that would compromise the subject's safety or successful participation in the study, in the opinion of an investigator or treating physician * pregnant or breast feeding patients; a urine pregnancy test will be performed in women of child-bearing potential prior to \[18f\]f-tmp injection, to confirm non-pregnant status
effect of antiviral therapy on host immune in patients with chronic hepatitis b virus(hbv) infection

Conditions: HBeAg Positive Chronic Hepatitis B Infection

Summary: during hepatitis b virus(hbv) infection host immune plays important role.recently there are many different antiviral therapy methods.different antiviral therapy methods showed different effector.in order to investigate whether these antiviral therapy methods especially methods directly inhibit viral replication have some effect on host immune the investigators designed these study. the investigators want to observe the change of host immune during antiviral therapy in patients with chronic hbv infection, and analyze the relationship between these changes and the antiviral effector of these drugs.


Eligibility criteria:
inclusion criteria: * 18-65 years old * chronic hbv infection * hbeag positive,hbv dna more than 10e5 iu/ml * alt ≥2×utl exclusion criteria: * with liver cancer * with liver failure * pregnant

Keywords: hbv immune antiviral therapy