Kornimate/medical-research-clean huggingface dataset:
the use and reproducibility of duplex ultrasound to provide indices of left common iliac vein diameter

Conditions: May-Thurner Syndrome

Summary: the goal of this feasibility/pilot study is to investigate whether or not vascular ultrasound can be used to aid the diagnosis of may thurner syndrome, in adult patients presenting to the vascular department with unexplained left leg swelling. the main research objective it aims to answer are: * the diameter variation of the left common iliac vein based on posture, using duplex ultrasound. * to determine inter- and intra-observer variation of the diameter measurement of the left common iliac vein using duplex ultrasound. participants will have an ultrasound scan performed on their abdomen by three different clinical vascular scientists, and will have each scan performed whilst lying supine on an examination couch and again when the couch is tilted to 45 degrees. researchers will compare the results of symptomatic patients to asymptomatic patients, to see if there is a difference in the diameter of the left common iliac vein between these two groups.


Eligibility criteria:
inclusion criteria: * participant has the capacity to consent * participant is required to have a vascular ultrasound scan in the vascular ultrasound department * participant is 18 years of age or older at the start of the study. exclusion criteria: * previous iliac vein intervention or treatment for iliac vein disease * previous diagnosis of iliac vein thrombus * pregnancy * unable to provide appropriate informed consent * the participant does not require a vascular ultrasound as part of their routine care * under 18 years of age at the start of the study
safety and efficacy study of transplantation of autologous cd34+ cells transduced with the g2arte lentiviral vector expressing the dclre1c cdna in artemis (dclre1c) deficient severe combined immunodeficiency patients (artegene)

Conditions: Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency

Summary: the purpose of this study is to evaluate the safety and efficacy of gene therapy of the severe combined immunodeficiency (scid) caused by mutations in the human dclre1c gene (artemis) by transplantation of a single dose of autologous cd34+ cells transduced ex vivo with the g2arte lentiviral vector expressing the dclre1c cdna.


Eligibility criteria:
inclusion criteria: * patient to 47 months * scid patients with confirmed biallelic mutations in the artemis (dclre1c) gene even in the case of leaky forms characterised by a residual activity * absence of an hla genoidentical donor or without rapidly available hla-compatible unrelated donor (within six weeks of diagnosis) * the patient can be treated by gene therapy without delay in case of active life threatening infections compromising the short-term prognosis and for which the delay in finding a phenoidentical donor is incompatible with the patient's condition of health. active life threatening infections are defined as: viral respiratory infection, cmv infection, adenovirus infection, disseminated bcgitis or other infections grade ≥ 4 according to ctcae scale * beneficiary of a social security scheme * parental, guardian's patient signed informed consent. exclusion criteria * unwillingness to return for follow-up during the first 2 years study and the long term follow-up * hiv-1 or 2 or htlv1 infections * hypersensitivity to g-csf, busulfan or fludarabine * unable to tolerate general anesthesia and/or marrow harvest or peripheral blood stem cell collection (apheresis) or insertion of central venous catheter.

Keywords: artemis deficient severe combined immunodeficiency severe combined immunodeficiency gene therapy allogeneic hematopoietic stem cells transplantation
effects of a walking intervention with additional weights on the unaffected leg in people after stroke

Conditions: Stroke; Hemiparesis

Summary: this study is designed to determine if adding daily weighted braces on the unaffected ankle may benefit to patient who have returned home compare to a placebo intervention (ankle brace without weight).

improve walking ability in people after stroke is a key objective for rehabilitation. once the rehabilitation period is finished, a reduction of functional and motor abilities is often observed in subjects when they returned home. this study will examine if loading daily the non paretic leg with additional weights will improve walking abilities. this study will enroll 100 people who had a stroke \> three months and \< five years and who still experienced difficulties for walking. each patient will receive 3 months of intervention targeting their non affected leg. half of the subjects will have to wear braces with additional weights at the non affected ankle during the day ( \> 6 hours), while the other half will wear a similar brace but without weight. a six minutes walking test will be given before and after the intervention, as well six and twelve months later to measure the effect of these interventions. the investigators hypothesize that people receiving the additional weights to the non paretic leg will show greater improvements in their walk abilities.

Eligibility criteria:
inclusion criteria: * hemiparesis following ischemic or hemorrhagic infarct of a single hemisphere * first episode of stroke experienced \> 3 months and \< 5 years prior to study enrolment * functional ambulation categories (fac) score \> 3 \< 8 * be able to walk few meters without physical assistance * able to understand and follow instructions exclusion criteria: * following inpatient physical rehabilitation * experienced more than 2 falls during 3 months prior inclusion * signs of bilateral impairments * daily use of a wheelchair to move * contra-indications for daily walk * currently participating in any clinical trial with a experimental walking intervention * severe arthrosis * dementia

Keywords: resistance training walking weight bearing
impact of the no-donor pentaerythrithyltetrantrate on perinatal outcome in high-risk pregnancies

Conditions: High Risk Pregnancy

Summary: pregnancies resulting in iugr and also in preeclampsia are strongly associated with typical underlying placental pathology revealing small placentas and maldevelopment of the decidual blood vessels, suggesting under-perfusion from the maternal circulation. since nitric oxide (no) donors can improve decreased uteroplacental perfusion without any negative effects on fetal circulation, these may prevent negative pregnancy outcomes in patients at risk. the aim of this study is to evaluate the effectiveness of the long-lasting no donor pentarythrithyltetranitrate (petn) to reduce the likelihood of adverse pregnancy outcomes (intrauterine growth retardation / iugr, perinatal death, placental abruption, and preterm delivery) in women recognized to be at risk for this outcome by abnormal uterine flow in mid gestation.


Eligibility criteria:
inclusion criteria: * pregnant women 190 to 236 weeks of gestation * abnormal uterine doppler as defined by bilateral notching, unilateral notching and increased impedance with mean resistance index (ri) \> 0.65 or with mean ri \> 0.7 without notching at time of enrollement * informed consent exclusion criteria: * multiple gestation * documented chromosomal or major fetal abnormalities * rupture of membranes and/or clinical chorioamnionitis at time of enrolment * maternal disease defined as contraindication for intake of petn

Keywords: abortion perinatal death iugr preterm birth placental abruption preeclampsia
voiceitt for people with impairments in speech

Conditions: Speech Impairment; Speech Disorder

Summary: the primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (cp), stroke, amyotrophic lateral sclerosis (als), or parkinson's disease.

conditions like cp, als, stroke or parkinson's disease, etc., cause communication impairment. there are few augmentative communication options that allow people with these impairments to communicate effectively. voiceitt is an app that is designed to assist people with speech impairments by using a voice recognition and dictation tool that adapts to users' unique, non-standard speech patterns. however, its effectiveness in clinical populations has not been established. this study is bridging the gap in evaluating the preliminary effectiveness and feasibility of voiceitt app in improving communication among people with mild to moderate speech impairments.

Eligibility criteria:
inclusion criteria: * age 13 or older * moderately severe speech dysarthria due to conditions such as cp, stroke, als or parkinson's disease, etc. * ability to understand and follow instructions for using the voiceitt app. exclusion criteria: * severe cognitive impairments that prevent the understanding of the voiceitt app and required training. * patients who have additional speech impairments other than dysarthria, such as significant aphasia or verbal apraxia. * severe physical impairments that prevent interaction with the app. * non-english speakers.

Keywords: speech impairment voice recognition tool dictation tool voice recognition app dictation app voiceitt app speech disabilities dysarthria moderate dysarthria
study of women with acute coronary syndromes and nonobstructive coronary artery disease

Conditions: Acute Coronary Syndromes

Summary: approximately 600,000 women are treated for acute coronary syndrome (acs) annually in the us. acs includes heart attack and a milder form called unstable angina. many of these women have angiograms of which 14-39% show no "significant" coronary artery disease (cad, cholesterol plaque accumulation in arteries of the heart). the remaining majority of women with acs have cholesterol plaque buildup which appears severe enough on angiography to limit blood flow to the heart. it is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again. additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way. some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound (ivus). ivus involves creating pictures of the artery walls using ultrasound (sound waves) from within the artery itself. in some women without major heart artery blockage, heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or ivus. this problem can be found using magnetic resonance imaging (mri), which can show blood flow to the heart. mri may also be used to show where the heart has been damaged. the pattern of damage could suggest that a heart attack in a woman, who has no badly blocked heart arteries, happened for one (or more) of these reasons or another reason. the study of women with acs and non-obstructive cad (swan) will use ivus and mri to help determine the reasons for heart attacks in women with no major blockages in heart arteries.


Eligibility criteria:
inclusion criteria: * women * positive cardiac markers and/or st elevation * scheduled for angiography exclusion criteria: * prior diagnosis of obstructive cad * contraindication to ivus and/or mri * use of vasospastic agent

Keywords: sex acute coronary syndromes normal angiogram no obstruction at angiography women
high-dose chemotherapy in treating patients with advanced stomach cancer

Conditions: Gastric Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug and giving higher doses may kill more tumor cells. purpose: randomized phase ii trial to study the effectiveness of high-dose chemotherapy in treating patients with advanced stomach cancer.

objectives: i. determine the response rates in patients with advanced gastric cancer treated with high-dose fluorouracil (5-fu) with vs without high-dose leucovorin (cf) vs high-dose 5-fu/cf/cisplatin. ii. determine the toxic effects of these regimens in these patients. iii. assess the symptomatic improvement in these patients treated with these regimens. outline: this is a randomized, multicenter study. patients are stratified according to participating center, who performance status (0 or 1 vs 2), and disease stage (metastatic vs locally advanced). patients are randomized to 1 of 3 treatment arms. arm i: patients receive fluorouracil (5-fu) iv over 24 hours weekly for 6 weeks. arm ii: patients receive leucovorin calcium (cf) iv over 2 hours followed by 5-fu iv over 24 hours weekly for 6 weeks. arm iii: patients receive cf and 5-fu as in arm ii and cisplatin iv over 1 hour on days 1, 15, and 29. treatment repeats every 7 weeks for a maximum of 4 courses in the absence of unacceptable toxicity or disease progression. patients are followed every 8 weeks. projected accrual: a total of 65-135 patients (21-45 per arm) will be accrued for this study.

Eligibility criteria:
disease characteristics: histologically confirmed gastric cancer that is either metastatic or locally advanced and inoperable bidimensionally measurable disease no cns metastasis patient characteristics: age: 75 and under performance status: who 0-2 life expectancy: at least 3 months hematopoietic: granulocyte count at least 2,000/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.7 mg/dl renal: creatinine no greater than 1.3 mg/dl creatinine clearance greater than 60 ml/min cardiovascular: no myocardial infarction within past 12 months no coronary heart disease requiring drug therapy congestive heart failure or arrhythmia treatable with standard medication allowed other: no active infection no history of severe mental disorder no other malignancy within past 10 years except carcinoma in situ of the cervix or nonmelanoma skin cancer not pregnant prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior chemotherapy endocrine therapy: not specified radiotherapy: no prior radiotherapy surgery: not specified

Keywords: stage iii gastric cancer stage iv gastric cancer
alternative treatment of giant spinal schwannomas

Conditions: Spinal Cord Neoplasms

Summary: schwannomas are benign tumors that can reach giant sizes. the diagnosis and treatment of these cases differ from those of small schwannomas. the aim of this study was to review the diagnoses and surgical approach characteristics of the giant spinal schwannomas (gss) of patients who underwent surgery.


Eligibility criteria:
inclusion criteria: * patients diagnosed with benign spinal schwannoma sridhar type iii, iv and v exclusion criteria: * malign spinal schwannoma * sridhar type i and ii
a randomized controlled trial on the effect of exercise on physical, cognitive and affective function in dementia subjects

Conditions: Dementia

Summary: studies have shown conflicting results of the effect of exercise on dementia patients. the aim of this study is to examine the role of physical activity on the risk of cognitive impairment and dementia in older persons. to promote the benefits of aerobic exercise on dementia patients and encourage exercise prescription in the management of dementia subjects.


Eligibility criteria:
inclusion criteria: * mmse\<26 * age \>60 * community dwelling and ambulatory * have a caregiver that is willing to participate and escort patient to hospital for training and assessment exclusion criteria: * mmse\<10 * live in old age home * poor mobility, unable to attend exercise training * no carer to bring patient to attend hospital training

Keywords: dementia
designing animated movie for preoperative period

Conditions: Postoperative Pain; Fear; Surgery; Pain; Nursing Caries; Nurse's Role; Clinical Anxiety; Patient; Pediatric

Summary: background: using visual materials is effective in education to decrease children's pre-operative fear and post-operative pain. children, especially those aged between 6 and 12 years, are interested in technology. this study aims to investigate the effects of watching an educational animated movie in the pre-operative period on fear and postoperative pain in children who are having surgery. methods: the study was a prospective randomized controlled trial. this study was conducted between 6- to 12-year-old children in the pediatric surgery clinic of ege university medical faculty hospital. the current study includes data from 132 children who were chosen doing block randomization. the "child and family identification data form", "children's fear scale" and "wong-baker faces pain rating scale" was used in data collection. the patients were divided randomly into three groups as the "educational animated movie group" (eamg), "documentary movie group" (dmg) and "control group" (cg). the educational animated movie and documentary movie were screened using virtual reality (vr). data were collected by the researcher in the pre-operative period. the pre-operative fear of the child was evaluated by the child and the parent, and the post-operative pain of the child was evaluated by the child, parent, and nurse using scales about fear and pain.


Eligibility criteria:
inclusion criteria: * first surgery * daily surgery and uncomplicated surgery * agree to participate in the study * speaking turkish exclusion criteria: * refusal to participate in the study * a genetic/congenital disease * a chronic disease * second or more surgery * not speaking turkish

Keywords: pediatric surgery preoperative preparation animation fear pain nursing
efficacy and safety study of symbicort turbuhaler in chinese patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study aims at evaluating efficacy and safety of symbicort® turbuhaler® in chinese copd patients as defined by gold treatment guidelines in order to obtain an approval for indication of copd from chinese state food and drug administration.


Eligibility criteria:
inclusion criteria: * signed and dated inform consent * out-patient, clinical diagnosis of copd * men or women at the age of 40 or over exclusion criteria: * a history of asthma * seasonal allergic rhinitis before 40 years of age * patients with significant or unstable ischemic heart disease, arrhythmia, cardiomyopathy, heart failure, uncontrolled hypertension as defined by the investigator or other disorder

Keywords: chinese patients copd
evaluation of the interest of a postural and functional analysis for the follow-up of the adapted motor activity of patients treated for breast cancer

Conditions: Breast Cancer

Summary: the goal of this clinical trial is to evaluate the acceptability by patients treated for breast cancer of an adapted motor activity program over a period of 15 months controlled by a postural and functional analysis.. participant population/health conditions: patients with newly operated breast cancer who are candidates for an adapted physical activity program

this is a prospective, longitudinal, single-center, open-label study of a population of newly operated breast cancer patients who were candidates for an adapted motor activity program. all included patients will be followed for a period of 15 months. participating physicians will have the opportunity to recruit their patients during the 24 months following the study's initiation. the study will be completed once the last included patient has a final evaluation. the total duration of the study is 39 months (24 months of recruitment and 15 months of follow-up). each patient will be assessed four times: at inclusion before initiation of cancer treatment, and at m3, m9 and m15. at each patient visit with the investigating physician, an assessment will be completed on the electronic crf by the physician or by the site cra under the responsibility of the investigating physician.

Eligibility criteria:
inclusion criteria: * adult woman, having given her consent to participate in the study, * patient with non-metastatic breast cancer, * cancer to be treated by surgery with or without adjuvant treatment (radiotherapy and/or chemotherapy). exclusion criteria: * contraindication to the practice of a physical activity, * mental deficiency or any other reason that could hinder the understanding or the strict application of the protocol, * patient not affiliated to the french social security system, * patient under legal protection, guardianship or curatorship, * patient already included in another therapeutic study protocol aimed at evaluating the benefits of adapted physical activity.
gait rehabilitation to treat fastoa

Conditions: Anterior Cruciate Ligament Injuries; Post-traumatic Osteoarthritis; Knee Osteoarthritis; Osteo Arthritis Knee; Knee Injuries; Cartilage, Articular; Gait

Summary: the purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of fastoa and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.


Eligibility criteria:
inclusion criteria: * have completed all other formal physical therapy * are between the ages of 16 and 35 * underwent an anterior cruciate ligament reconstruction (aclr) between 6 and 60 months prior to enrollment * demonstrate underloading during gait (vgrf- impact peak \<1.12 x bw) exclusion criteria: * a multiple ligament surgery (i.e., pcl) * a lower extremity fracture (i.e., displaced tibial plateau fracture) * knee osteoarthritis * the participant has a bmi ≥ 36.

Keywords: biofeedback fastoa
prognostic study of gastric malt lymphoma after eradication of helicobacter pylori

Conditions: Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive

Summary: to survey the grade of gastric malt lymphoma after eradication of helicobacter pylori


Eligibility criteria:
inclusion criteria: * gastric low-grade mucosa-associated lymphoid tissue (malt) lymphoma with helicobacter pylori positive * the stages of malt lymphoma are lugano international conference classification stage i or ii 1 and wotherspoon grade 4 or 5 exclusion criteria: * with diffuse large b-cell lymphoma * have been treated to gastric mucosa-associated lymphoid tissue (malt) lymphoma * corresponding to contraindication of each drug

Keywords: rabeprazole sodium helicobacter pylori stomach neoplasms
clinical applications of domperidone in patients with delayed gastric emptying

Conditions: Digestive System Disease

Summary: the purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy

this is a study on the effectiveness of domperidone, which increases movement through the digestive system for relief of symptoms, in patients who have delayed gastric solid-phase emptying

Eligibility criteria:
inclusion criteria: * persistent esophagitis * heartburn * nausea * vomiting * severe dyspepsia * severe chronic constipation exclusion criteria: * history of, or current arrhythmias including ventricular tachycardia, - ventricular fibrillation and torsade des pointes.

Keywords: digestive system diseases disease