Kornimate/medical-research-clean huggingface dataset:
effects of inpatient pulmonary rehabilitation on frailty in patients after lung-transplantation

Conditions: Advanced Lung Disease; COPD; Interstitial Lung Disease

Summary: frailty is closely linked to the success of lung transplantations (ltx) (1,2). studies have shown that frailty causes a diminished physical performance in candidates for ltx and an increased 30 day rate of re-hospitalization after surgery. furthermore, frailty is associated with a higher one-year-mortality rate after ltx in frail compared to non-frail patients (1,3,4). some evidence that frailty in ltx-candidates can be decreased by a suitable rehabilitation program suggests that improving the frailty status in post-ltx patients can be a further strategy to contribute to an overall success in ltx. however, at the moment these possible benefits are not investigated yet. therefore the aim of this study is to observe the effect of a three-week inpatient rehabilitation on frailty in patients after ltx.

rationale: frailty is a complex clinical syndrome describing a loss of physical and/or cognitive functionality which leads to a decreased resistance to stressors such as operations or illness. it is associated with increased number of falls, exacerbations, adverse health outcomes and a higher mortality (7-10). frail ltx-candidates have a higher risk of being delisted before transplantation, adverse transplantation outcomes and a higher one-year-mortality compared to non-frail candidates. however, studies show that frailty can be decreased by physical training (11-13). a recent prospective cohort study in the uk observed a significant decrease of frailty in patients with copd participating at an inpatient rehabilitation program (5). singer et al. (usa) could detect a significant decrease of frailty by a homebased training for ltx-candidates (6). aim of this study is to investigate the effects of a three-week inpatient rehabilitation program on physical frailty (measured by short physical performance battery) in patients after ltx. additionally, other functional measures as well as the cognitive, social and psychological state will be assessed in order to better understand the complex syndrome of frailty and the effects of rehabilitation. design: this study is a prospective observational trial. the number of 30 participants is based on a sample size calculation. assessments will take place in the beginning of rehabilitation program and at discharge.

Eligibility criteria:
inclusion criteria: * participation in an inpatient pulmonary rehabilitation programme (schön klinik bgl, germany) * patient after lung transplant (\< 1 year) * indication: copd or ild * written informed consent exclusion criteria: * non compliance at assessments * re-transplantation

Keywords: lung transplantation pulmonary rehabilitation exercise training frailty lung diseases respiratory tract diseases
use of nitrous oxide donor for labor induction in women with preeclampsia

Conditions: Preeclampsia; Labor, Premature

Summary: a randomized controlled trial (rct) of nitric-oxide donor (nod) isosorbide mononitrate (imn) versus placebo as an adjuvant to misoprostol/ intra-cervical foley bulb for induction of labor to decrease rate of cesarean deliveries in pregnancies complicated by preeclampsia (≥24/0 weeks' gestation)

the investigators are proposing a double blinded, placebo controlled, randomized clinical trial of patients undergoing induction of labor for preeclampsia. once the decision to induce will be taken, the participants will be randomized to receive either intravaginal imn (40mg) or identical appearing placebo placed every 4hrs in the posterior vaginal fornix x 3 doses. imn or placebo will be discontinued when active labor occurs or when the physician decides to proceed with augmentation with oxytocin or arom. participants will be induced using the investigators routine induction agents, misoprostol (25 mcg every 4 hrs for maximum of 6 doses) and an intra-cervical foley bulb will be inserted with 2nd dose of imn or placebo. regarding management of labor, physician decides when to proceed with augmentation with oxytocin or arom.

Eligibility criteria:
inclusion criteria: * women older than 18 years at the time of induction of labor with the ability to give informed consent * induction of labor for clinical diagnosis of preeclampsia * unfavorable cervix (bishop's score of less than 6) * cervical dilation 2cm or less * singleton * gestational age ≥ 24 weeks * english speaking exclusion criteria: * • contraindication to vaginal delivery * contraindication to misoprostol * fetal demise * major fetal anomaly * non-english speaking women * hiv * medical conditions requiring assisted second stage * category iii tracing * eclampsia * hemolysis elevated liver enzymes low platelets syndrome * dic or active hemorrhage before randomization * hypersensitivity to isosorbide mononitrate * isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (hocm), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e.g following a head trauma and including cerebral hemorrhage. * isosorbide mononitrate should not be used in patients with severe anemia, severe hypotension, closed angle glaucoma or severe hypovolaemia. * isosorbide mononitrate tablets contain lactose and therefore patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Keywords: preeclampsia induction
the study of ltbp1 of postmenopausal women osteoporosis molecular mechanism of kidney yang deficiency syndrome

Conditions: Kidney Yang Deficiency Syndrome

Summary: postmenopausal osteoporosis is characterized by a decrease in bone mass as well as a deterioration of the bone architecture resulting in an increased risk of fracture,which is directly related to the lack of estrogen and also associated with a variety of genetic and acquired factors. previous studies have found that pop molecular regulation mechanism of kidney yang deficiency syndrome may be associated with ltbp1 gene expression. this topic using rt-pcr and western blot detection pop of kidney yang deficiency group and healthy group ltbp1 mrna and proteion's expression level,validate ltbp1 relevance to pop the kidney yang deficiency syndrome.to provide a scientific basis for clinical treatment.


Eligibility criteria:
inclusion criteria: * • the participants who volunteer to be test subjects, and can accept experimental drugs, and promise to finish the course should sign the informed consent. * female ages 45 to 75 had gone through natural menopause before two years * in accordance with the western medicine diagnostic criteria of osteoporosis and belong to kidney yin deficiency syndrome differentiation of traditional chinese medicine certificate; * in accordance with the western medicine diagnostic criteria; * in accordance with tcm diagnostic methods; .if any of the above answers are no, the subjects couldn't in the study exclusion criteria: * do not accord with standard of the western medicine diagnosis and tcm diagnostic methods * age: \ 76 years old; * with hyperparathyroidism, osteomalacia, rheumatoid arthritis, multiple myeloma and other serious complications such as secondary osteoporosis; late or deformity, disability, loss of labor; * with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases; * psychosis or alzheimer's patients; * nearly three months, the use of hormone replacement therapy (hrt) and taking calcitonin, nearly six months has used double phosphonic acid salt for 15 days, etc.; * this medicine allergic constitution or composition of known to have allergies; * in a critical condition, it's difficult to make exact evaluators to efficacy and safety of the new drugs;
role of propolis paste in preventing pain after root canal treatment.

Conditions: Pain, Postoperative

Summary: this study evaluates the role of propolis paste as compared to calcium hydroxide (when used as intracanal medication) in prevention and treatment of pain after root canal treatment in necrotic (infected) teeth. half of the participants will receive calcium hydroxide, while the other half will receive propolis.

propolis is a developing herbal medicament used in various aspects on dentistry. it is extremely biocompatible; has flavanoids; which acts as anti-inflammatory and antimicrobial components. calcium hydroxide is a synthetic medication which is antibacterial

Eligibility criteria:
inclusion criteria: * single rooted necrotic teeth with symptomatic or asymptomatic periapical periodontitis having periapical widening or radiolucency without bone expansion (pai index 2, 3 and 4). * teeth with favorable root morphology. * teeth with closed apex. exclusion criteria: * teeth with pai index 1 and 5. * patients who are on antibiotics. * patient with recent trauma to the jaw. * teeth with open apex * multi-rooted teeth. * vital teeth. * non-restorable teeth. * unfavorable root morphology (severely curved, dilacerated, severely sclerosed or obliterated). * teeth associated with soft tissue abscess or swelling. * teeth with external or internal root resorption * re-treatment cases. * periodontally compromised teeth (like mobile teeth and teeth with excessive bone loss). * teeth requiring endodontic surgery. * teeth requiring non-surgical endodontic treatment of multiple teeth in the same or opposing quadrant. * medically compromised patients (asa-iii and above), patients with special communication needs or who doesn't understand urdu or english language. * patients allergic to bee pollen or honey products.

Keywords: flare up
buparid/pari sinus versus budes® nasal spray in the therapy of chronic rhinosinusitis

Conditions: Rhinosinusitis

Summary: the study should create data for the selection of a clinically relevant endpoint to assess the potential of buparid/pari sinus to postpone sinus surgery in patients with chronic rhinosinusitis.

the objective of this study is to analyse whether buparid/pari sinus has a higher potential to avoid or postpone sinus surgery in adult patients with crs than standard of care therapy with budes® nasal spray. the results of this study are expected to provide estimates for a proper sample size calculation to conduct a pivotal study.

Eligibility criteria:
inclusion criteria: * patient with confirmed diagnosis of chronic rhinosinusitis * patient without alternative other than sinus surgery * patient's written informed consent obtained prior to any screening or study-specific procedure * male or female, ≥ 18 years of age * patient is able to undergo nasal therapy without restrictions * capable to correctly use the pari sinus device * capable of understanding the purpose and risk of the clinical trial * female patients with childbearing potential must have a negative urine pregnancy test prior to first imp administration. * patient is able to participate in the study according to investigator's opinion exclusion criteria: * patients with cystic fibrosis * patients with polyposis nasi grade i-iv * patients with prior fess (functional endoscopic sinus surgery) * pregnant or breastfeeding women * any active invasive bacterial, viral or fungal infection within one week prior to first investigational medicinal product (imp) administration * no clinically relevant abnormal parameters of vital signs, blood biochemistry or renal/hepatic function * unlikely to comply with visits, inhalation procedures or other measurements scheduled in the protocol * receipt of an investigational drug as part of a clinical trial within 4 weeks prior to first administration of imp * any co-existing medical condition that in the investigator's judgement will substantially increase the risk associated with the patient's participation in the clinical trial * psychiatric disorders or altered mental status precluding understanding of the informed consent process and/or completion of the necessary procedures * drug or alcohol abuse * end-stage malignancies * known hypersensitivity to budesonide * patients with oral steroid therapy within the last 3 months * patients needing \> 1 mg/day budesonide (or steroidal equivalent) for therapy of asthma * patients on therapy with leukotriene-receptor antagonists, decongestants, antihistamines or antibiotics * patients with frequent epistaxis (\> 1 episode per week)

Keywords: crs without polyposis
health coaching based treatment versus usual treatment of systemic arterial hypertension and comorbidities

Conditions: Hypertension, Resistant to Conventional Therapy

Summary: hypertension is a multifactorial clinical condition, it may not cause symptoms and its diagnosis is often delayed. and even when it is diagnosed early, some patients cannot manage an adequate blood pressure. there are several hypotheses for the non-control of blood pressure, among them the difficulty of lifestyle change, irregular treatment with antihypertensive drugs, non-individualized treatment. studies haven shown that tools such as multiprofessional team and hypertension leagues are important strategies to obtain a better outcome in the hypertension treatment, but new approaches are still necessary. health coaching is an individualized form of follow-up, promoting better adherence, better nutrition, smoking cessation, regular physical exercise and regular use of drugs, thus reducing cardiovascular mortality.

drug adherence and lifestyle changes are tools for chronic disease control. the relationship between nutrients, alcohol intake, and weight change in blood pressure was demonstraded in one study, demonstrating the importance of lifestyle change. studies have shown that multiprofessional team and hypertension leagues are important strategies to obtain a better outcome, but new approaches to the patient are still necessary. health coaching is an individualized follow-up, promoting better adherence to the hypertension treatment. health coaching is a new model based on the support of the individual, for a better autonomy in personal care. the process engages de patient with the conditions of the disease itself by increasing knowledge, skill and confidence so that the patient become informed, active in the participation of its own care. among health care, training is characterized by the expression. of concerns, answering questions, providing information on home-based follow-up, and collaborative development of health care plans. motivated patients are more likely to treatment adherence and more committed to making lifestyle changes and thus effectively managing their illness. the research is a randomized clinical trial comparing treatment based on health coaching and the usual treatment based in the treatment of hypertension and comorbidities in uncontrolled hypertensive patients.

Eligibility criteria:
inclusion criteria: * blood pressure above 160/90mmhg * signed the free and informed consent form * regularly enrolled, with at least two visits in the last 12 months exclusion criteria: * miss the subsequent consultation * those who have not signed the free informed consent form.
evaluation of pharmacogenetic testing in a mental health population and economic outcomes

Conditions: Major Depressive Disorder 1

Summary: this is a non-randomized, single-case design of pharmacogenetic implementation in a mental health patient population of subjects taking antipsychotics and/or antidepressants.

this is a non-randomized, single-case design of pharmacogenetic implementation in a mental health patient population of subjects taking antipsychotics and/or antidepressants. retrospective and prospective data will be collected on all subjects before and after pharmacogenetic recommendations have been made. retrospective data will be collected for the previous 12 months before pharmacogenetic recommendations are made and prospective data will be collected for 12 months after pharmacogenomic recommendations have been made.

Eligibility criteria:
inclusion criteria: * must be taking either an anti-depressant or an anti-psychotic medication * must provide informed consent * must have avera health plans insurance coverage * must have three months of participation in the avera care coordination program exclusion criteria: * must not be pregnant or breastfeeding * must not have an active and/or unstable diagnosis of substance abuse * must not have a primary diagnosis of dementia, bulimia, or anorexia nervosa disorder * must not have had a previous pharmacogenetic evaluation

Keywords: depression major depressive disorder mdd mental health pharmacogenomics personalized medicine precision medicine anti-depressants
clinician decision support algorithm for chemotherapy-induced peripheral neuropathy

Conditions: Cancer; Chemotherapy-induced Peripheral Neuropathy

Summary: this research study is evaluating how well a decision support tool works to improve clinicians' use of recommended chemotherapy-induced peripheral neuropathy (cipn) assessment and management strategies in participants receiving chemotherapy.

this research study will test a new clinician decision support tool for the assessment and management of cipn. the algorithm is designed to help clinicians make decisions about which strategies to use for the assessment and/or management of cipn. the investigators need to recruit participants receiving chemotherapy that is known to cause cipn to determine how well the algorithm works to increase clinicians' use of recommended cipn assessment and management strategies.

Eligibility criteria:
inclusion criteria for patients: * over 18 years of age, * completed one infusion of neurotoxic chemotherapy for the treatment of cancer * has at least three more planned clinic visits associated with neurotoxic chemotherapy receipt after the day of consent * ambulatory, * signed informed consent, * willingness to participate in all study activities, * speaks/reads english, * receives care from one of the clinicians enrolled in the study. exclusion criteria for patients: * prognosis of ≤ two months or * documented peripheral neuropathy due to other causes (diabetes, alcohol abuse, central nervous system malignancy, vitamin b deficiency, hereditary, nerve compression injury). inclusion criteria for clinicians: -if they are a medical doctor, physician assistant, or nurse practitioner and provide care to oncology patients at one of the study sites inclusion criteria for healthy controls: -if they are an adult (18+) who does not have cancer or symptoms of peripheral nerve injury from any cause and speak/read english

Keywords: cancer care chemotherapy-induced peripheral neuropathy
tvmr with the innovalve system trial - early feasibility study

Conditions: Mitral Valve Regurgitation (Degenerative or Functional)

Summary: study to evaluate the safety and performance of the innovalve mitral valve replacement system

the study is a multi-center, first-in-human, prospective, single arm early feasibility study to evaluate the safety and performance of the innovalve mitral valve replacement system

Eligibility criteria:
inclusion criteria: * clinically significant, symptomatic mitral regurgitation * high risk for open-heart surgery * meets anatomical criteria exclusion criteria: * unsuitable anatomy * patient is inoperable * ef\<25%
expiratory muscle training versus incentive spirometry after colorectal surgery

Conditions: Colorectal Cancer; Pulmonary Rehabilitation

Summary: the aim of this study was to compare the effects of expiratory muscle training (emt) and incentive spirometry (is) in addition to conventional pulmonary rehabilitation after colorectal surgery. twenty-four individuals (13 male) undergoing colorectal surgery were included. they were randomly divided into two groups. in addition to conventional chest physiotherapy, group 1 was performed emt (n=12), group 2 was performed deep breathing exercises with incentive spirometry (is) in postoperative period. respiratory muscle strength, functional capacity, levels of movement and independence, and postoperative pulmonary complications (ppc) were evaluated. length of stay in hospital (los) was recorded.

the aim of this study was to compare the effects of expiratory muscle training (emt) and incentive spirometry (is) in addition to conventional pulmonary rehabilitation after colorectal surgery. twenty-four individuals (13 male) undergoing colorectal surgery were included. they were randomly divided into two groups. in addition to conventional chest physiotherapy, group 1 was performed emt (n=12), group 2 was performed deep breathing exercises with incentive spirometry (is) in postoperative period. respiratory muscle strength, functional capacity, levels of movement and independence, and postoperative pulmonary complications (ppc) were evaluated. length of stay in hospital (los) was recorded

Eligibility criteria:
inclusion criteria: * hemodynamically stable * able to walk independently * able to walk independently exclusion criteria: * any contraindication for chest physiotherapy (unstable cardiovascular disease, severe pulmonary hypertension, corrected severe hypoxemia, exercise desaturation, rib fractures, subcutaneous emphysema, advanced osteoporosis, thrombocytopenia, effort dyspnea and vertigo) * any metastases * severe chronic cardiovascular disease * candidates for organ transplantation * abdominal hernia repair * history of surgery more than one year * orthopaedic or neurological disease that would prevent independent walking

Keywords: colorectal surgery expiratory muscle training pulmonary rehabilitation