Kornimate/medical-research-clean huggingface dataset:
identification of plasma mirnas as potential biomarkers in asthma exacerbation

Conditions: Asthma

Summary: we hypothesize that there is a statistically significant difference in mirna profiling and expression of subjects with asthma upon its exacerbation compared to patient's baseline level or following effective treatment of an exacerbation of asthma. therefore, plasma mirna profiling may provide noninvasive, highly specific and sensitive biomarkers for asthma exacerbation's detection and treatment follow-up.


Eligibility criteria:
inclusion criteria: * literacy: the subject must be able to read and comprehend english. consent: the subject must have the ability to give informed consent. type of subject: the subject must be seen in the outpatient setting at one of the clinics staffed by faculty members of the division of allergy and immunology, department of internal medicine, university of south florida college of medicine. * asthma: the subject must have a history of physician diagnosed asthma for at least 1 year and must have a current exacerbation of asthma requiring oral glucocorticosteroids. asthma exacerbation is defined below. asthma exacerbation (relapse or de novo) is defined as either: 1. an increase of asthma symptoms (cough, wheeze, chest tightness, and /or shortness of breath) that does not resolve within 2 hours after the use of rescue albuterol or corticosteroids and requires a medical visit or 2. during a scheduled visit, the subject has acute worsening of asthma symptoms and a reduction of \>20% in peak flow, which in the opinion of the investigator requires treatment with oral glucocorticosteroids. exclusion criteria: * females who are pregnant or lactating. * any other coexistent lung disease (copd, interstitial lung disease, allergic bronchopulmonary aspergillosis, tb, sarcoidosis). * any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the results if the condition/disease exacerbates during the study. the list of conditions/diseases that will result in exclusion if determined to be clinically significant includes, but is not limited to: uncontrolled hypertension; hematological, hepatic, neurological, thyroid, peptic ulcer, or renal disease; immunologic compromise; current malignancy. * past or current use of tobacco (\<10 pack year smoking history and no smoking within the last 5 years).

Keywords: asthma asthma exacerbations
feasibility of an exercise intervention

Conditions: HIV

Summary: the overall purpose of this research is to evaluate the effect of a home-based exercise program on physical function and to improve the health and quality of life for the hiv-infected older adult community.

subjects are being asked to participate in this study if they are infected with the human immunodeficiency virus (hiv), and they are 45 years of age or older.

Eligibility criteria:
inclusion criteria: * hiv positive, both genders, all races, english speaking individuals, age 45 years or older, on haart before enrollment. . exclusion criteria: * subject will be excluded if he/she has history or currently has severe cardiopulmonary illness, severe orthopedic or neuromuscular impairments, significant cognitive or sensory impairments, history of active malignancy, untreated depression, manic or psychotic disorder, and normal ppt score.

Keywords: aging physical activity physical function hiv frailty autonomous motivation depression
pupillary pain index and reaction to skin incision

Conditions: Pain; Anesthesia; Surgery

Summary: during routine general anesthesia (not standardized, left to the discretion of the attending anesthesiologist), pupillary pain index was measured one minute before skin incision. then, variations in heart rate, blood pressure and bispectral index during the three minutes following skin incision were recorded, as well as the occurrence of movements.


Eligibility criteria:
inclusion criteria: * patient requiring general anesthesia * surgical procedure involving a skin incision * no regional anesthesia * written informed consent exclusion criteria: - neurologic or ophthalmic disease
the effect of olfactory training in patients with covid-19 induced olfactory dysfunction

Conditions: COVID-19

Summary: aim: the aim is to investigate the effect of olfactory training with essential oils versus olfactory training with placebo-oils in patients with covid-19 induced olfactory dysfunction study design: the study is a placebo-controlled randomized clinical trial with an intervention group and a control group. the intervention group receive four essential oils with scents of orange, lavender, clove, and peppermint. patients in the control group receive a fragrance kit, consisting of the same containers, but with fragrance-free oils added. both groups are instructed to smell each of the four oils for 30 seconds in the morning and evening, over a three-month intervention period. patients are given a diary in which to record their olfactory training. the nurse or medical student instructing the patients in the training and performing the smell and taste tests is blinded. study population: patients referred to the unit for sense of taste and smell in the department of otorhinolaryngology head \& neck and audiology at rigshospitalet. inclusion criteria: * impaired sense of taste and smell following covid-19 \> 3 months * hyposmia (16.25-30.5) or anosmia (\<16) assessed by sniffin' sticks olfactory test for threshold, discrimination and identification (tdi) performed in the unit for sense of taste and smell with or without parosmia based on medical history * \> 18 years of age exclusion criteria: * cause of hyposmia, anosmia or parosmia other than covid-19 * does not read or speak danish * lack of compliance to perform daily olfactory training procedures: - tdi-test: to assess patients' sense of smell, the tdi-test with sniffin' sticks is used, which is a validated tool with normative data. questionnaires: - 'taste and smell tool for evaluation' is used to investigate quality of life related to impaired sense of taste and smell.


Eligibility criteria:
inclusion criteria: * olfactory dysfunction caused by covid-19 * hyposmia (16.25-30.5) or anosmia (\<16) with or without parosmia assessed by tdi test with sniffin sticks performed in the unit for sense of taste and smell * \> 18 years of age exclusion criteria: * cause of hyposmia, anosmia or parosmia other than covid-19 * does not read or speak danish * lack of compliance to perform daily olfactory training

Keywords: olfactory training quality of life olfactory dysfunction covid-19 parosmia
vestibular and multisensory influence on bodily and spatial representations

Conditions: Vestibular Disorders

Summary: the present project aims at describing how vestibular signals contribute to the multisensory mechanisms of bodily self-consciousness. there is a large body of data regarding the sensory and neural mechanisms of self-consciousness, but most studies have so far demonstrated the contribution of visual, tactile and proprioceptive signals to bodily self-consciousness. thus, most studies have neglected the contribution of the vestibular system, a major sensory system for spatial and bodily representations. the vestibular system is sensitive to head motions in space and head inclinations with respect to gravity and it should therefore contribute significantly to several bodily experiences. this contribution should be put under neuroscientific scrutiny. we believe that the current neuroscientific models of bodily self-consciousness will be incomplete until they incorporate the contribution of vestibular signals. the present project specifically aims at testing the hypothesis according to which vestibular signals significantly influence bodily self-consciousness, in particular first-person and third-person perspective taking and the internal body models (i.e. the body schema and body image). the present project also aims at describing how cortical vestibular processing is modified during experimental changes of perspective taking and viewpoint. in addition, the present project will describe whether vestibular disorders change performances in third-person perspective taking tasks and modify internal body models. this should help understanding bodily symptoms in vestibular-defective patients. to this end, we will combine approaches from psychophysics and electrophysiology (electromyography, electroencephalography) in healthy volunteers and behavioral approached in patients with vestibular disorders. these studies should further the understanding of how the brain processes vestibular signals, which is to date poorly understood. in addition, the outcome of the present project should help understanding the multiple and complex symptoms reported by patients with vestibular diseases, and should therefore improve their treatment.


Eligibility criteria:
inclusion criteria: * patient with chirurgical treatment for meuniere disease or accoustic neurinoma or with acute vestibular deficiency. exclusion criteria: * patient with neurological history * patient with a lack of motricity
stiffness of the skin and joints in relation to carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: the exact etiology of cts remains yet unknown. a rise in carpal tunnel pressure is well documented, but why this phenomenon occurs is yet unknown in most patients. there is an absolute or relative narrowing of the carpal tunnel, which results in a compression of the median nerve. the investigators postulate, that a stiffer flexor retinaculum (roof of carpal tunnel) will be less compliant. as a consequence of this stiffer retinaculum the pressure in the carpal tunnel will rise more quickly in stiff patients resulting in cts-complaints. a relation between connective tissue composition and joint stiffness is proven. this relationship possibly extends to a relation between stiffness of the skin, joint stiffness and the prevalence of cts.


Eligibility criteria:
inclusion criteria: * caucasian * carpal tunnel release or trigger finger or dupuytren or an acute trauma to the hand exclusion criteria: * hypo-/hyperthyroidism * diabetes * arthritis * pregnancy * obesity (bmi \>30) * anatomical anomalies

Keywords: carpal tunnel syndrome cts skinstiffness jointstiffness
detection of right ventricular dysfunction by portal vein doppler after cardiac surgery

Conditions: Postoperative Complications; Heart Diseases; Heart Failure; Heart Valve Diseases

Summary: right ventricular (rv) failure after cardiac surgery is associated with morbidity and mortality, but is hard to diagnose with conventional echocardiographic means. rv dysfunction may be associated with hepatic congestion, which may have an effect on portal veinous flow, but this has not been extensively. the investigators aimed determine whether an increased pulsatility in the portal venous flow was associated with rv dysfunction, after cardiac surgery at risk of rv dysfunction: mitral and tricuspid valve procedures.

in cardiac surgical patients, rv dysfunction is associated with organ hypoperfusion and venous congestion leading to increased morbidity and mortality. non-invasive methods used to assess rv function are 2d-echocardiographic measurement of tricuspid annular plane systolic excursion (tapse), rv ejection fraction (ef), rv fractional area change (fac), 3d assessment of rv function, tissue doppler assessment of velocities, and magnetic resonance imaging (mri). though mri is the gold standard method to assess rv function, it cannot be used in the perioperative period. in the present prospective observational study, the investigators investigated the association between the pattern of portal venous flow and rv function as assessed by echocardiography in the postoperative period.

Eligibility criteria:
inclusion criteria: * more than 18 years old * ability to provide an informed consent * planned mitral and / or tricuspid valve surgery under cardiopulmonary bypass. exclusion criteria: * insufficient echogenicity

Keywords: cardiac surgery echocardiography right ventricular dysfunction doppler portal vein doppler ventricular function
a study of the efficacy and safety of topiramate in the treatment fo obese, type 2 diabetic patients treated with metformin

Conditions: Obesity; Diabetes Mellitus, Type 2; Diabetes Mellitus, Adult-Onset

Summary: the purpose of this study is to compare the efficacy (in terms of weight and hemoglobin type a1c \[hba1c\]) and safety of topiramate (96 milligrams\[mg\] or 192 mg daily) with placebo in the treatment of obesity in type 2 diabetic patients receiving metformin.

topiramate is not approved for the treatment of obesity. this double-blind, placebo-controlled study is designed to assess the efficacy and safety of topiramate in type 2 diabetic patients with obesity who are well-controlled on metformin alone. patients are randomized to receive either topiramate (up to a target dose of 96 or 192 mg per day) or placebo for one year. assessments of efficacy include weight reduction, levels of hba1c (shows average blood sugar level over a few months), body mass index (bmi), and health related quality of life (hrqol) measures. safety evaluations (incidence of adverse events, vital signs, hypoglycemic events, electrocardiograms \[ecgs\], clinical laboratory values) are monitored throughout the study. the study hypothesis is that topiramate, combined with metformin and non-pharmacologic therapy, can effectively achieve significant weight reduction and is well tolerated. during the first 8 weeks, oral doses of matching placebo or topiramate are increased gradually to target dose (96 milligrams\[mg\] or 192mg daily); the dose will be maintained for 1 year, then gradually reduced and stopped

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes and receiving metformin monotherapy for at least the previous 4 months and on a stable daily dose for at least 2 months prior to enrollment * metformin total daily dose not to exceed 2.1 grams/day * body mass index \>= 27 and \< 50 * hba1c \< 11% * fasting plasma glucose \>= 126 and \< 240 * stable weight * female patients must be postmenopausal for at least 1 year, surgically incapable of childbearing, or practicing an acceptable method of contraception (requires negative pregnancy test) exclusion criteria: * known contraindication, or hypersensitivity to topiramate * use of other antidiabetic medications within the last 4 months * excessive weight loss * diagnosis of type 1 diabetes * history of severe or recurrent hypoglycemic episodes * severe pulmonary disease

Keywords: type 2 diabetes obesity metformin hemoglobin a1c adult-onset diabetes mellitus (aodm)
adderall xr (mixed salts of a single-entity amphetamine) and strattera ( atomoxetine hydrochloride) compared to placebo on simulated driving safety and performance and cognitive functioning in adults with adhd

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: evaluate the efficacy of treatment with adderall xr and strattera compared to placebo on simulated driving safety and performance of young adults with adhd as measured by driving safety scores derived by the driving simulator.


Eligibility criteria:
inclusion criteria: * primary diagnosis of adhd * not naive to pharmacologic adhd treatment * valid driver's license with a minimum of 3 years driving experience exclusion criteria: * recent history of drug dependence or substance use disorder * any specific cardiac condition that would, in the opinion of the investigator, require exclusion * history of seizure in last 2 years, tic disorder or tourette's disorder * female subject is pregnant or lactating
melatonin for neuroprotection following perinatal asphyxia

Conditions: Perinatal Asphyxia

Summary: the aim of this study is to examine the effect of combining melatonin to whole body cooling on the brain injury and outcome of neonates following perinatal asphyxia.

this is a prospective study on 30 neonates with moderate to moderately to severe hypoxic ischemic encephalopathy (hie) . hie infants are randomized into two groups: whole body cooling group (n = 15; receive 72 hours of whole body hypothermia) and melatonin/ hypothermia group (n = 15; receive hypothermia and 5 daily enteral doses of melatonin 10 mg/kg). serum melatonin, plasma superoxide dismutase (sod),and serum nitric oxide (no) are measured at enrollment and after 2 weeks for the two hie groups. the hie groups underwent electroencephalography at enrollment and at 2 to 3 weeks. brain mri was performed after 2 weeks of life. neurologic evaluations and denver developmental screening test ii assessments were performed at 6 months. a group of healthy newborns will be used as a control for baseline labs.

Eligibility criteria:
inclusion criteria: * inborn infants at term gestation (38-42 weeks) * apgar scores ≤ 3 at 5 minutes and/or delayed first breath (\>5 minutes after birth) * profound metabolic or mixed acidosis with serum bicarbonate levels of \<12 mmol/l in initial blood gas analyses * evidence of moderate or moderate to severe encephalopathy, such as lethargy, seizures, abnormal reflexes, or hypotonia, in the immediate neonatal period exclusion criteria: * twin gestation * maternal neuro-endocrinal disturbances including diabetes mellitus * chorioamnionitis or congenital infections * low birth weight less than 2.5 kg * congenital malformations of the central nervous system or gastrointestinal anomalies * chromosomal abnormalities * after 6 hours of birth. * patients in extremis such as: (1) hypoxemia requiring supplemental oxygen 100% fio2, (2) life threatening coagulopathy, or (3) deep coma.

Keywords: hie hypothermia encephalopathy anti oxidants mri
observational study on compliance of statin treatment of patients with high blood cholesterol levels

Conditions: Dyslipidemia

Summary: the purpose of the study is to show the compliance rates of the patients to statin treatment and the reasons of non-compliance.


Eligibility criteria:
inclusion criteria: * patients diagnosed with dyslipidemia and taking or planning to take statin treatment. * patients living in the same city of the study center. o patients aged 18 years and over. exclusion criteria: * patients with severe systemic disease * patients with alcohol and drug addiction and/or mental disease * patients nursing or pregnant, or planning to get pregnant during the study

Keywords: statins compliance dyslipidemia
multi-center clinical evaluation of two daily disposable contact lenses

Conditions: Myopia; Refractive Error

Summary: the purpose of this study is to compare the subjective performance of two daily disposable contact lenses with respect to comfort and handling.


Eligibility criteria:
inclusion criteria: * adapted soft contact lens wearer; * spherical distance contact lens prescription between -1.00 and -6.00 diopter (inclusive); * spectacle cylinder ≤0.75 diopter in the least astigmatic eye, ≤1.00 diopter in the other; * correctable to 6/9 (20/30) in both eyes; * read, understood and signed the informed consent; * willing to comply with the wear schedule; * willing to comply with the study visit schedule; * other protocol-defined inclusion criteria may apply. exclusion criteria: * any active corneal infection, injury or inflammation; * systemic or ocular allergies which might interfere with contact lens wear; * systemic or ocular disease which might interfere with contact lens wear; * strabismus or amblyopia; * corneal refractive surgery and any anterior segment surgery; * use of systemic/topical medication contraindicating contact lens wear; * use of gas permeable contact lenses within 1 month preceding the study; * participation in any concurrent clinical trial or in the last 30 days; * other protocol-defined exclusion criteria may apply.

Keywords: contact lenses daily disposable contact lenses silicone hydrogel contact lens comfort near-sighted
exercise capacity and physical activity levels in newly diagnosed hematologic malignant patients

Conditions: Hematologic Malignancies

Summary: hematologic malignancies are neoplasms that affect the blood, bone marrow, and lymph nodes. hematological malignancies are the most common forms of leukemia, lymphoma, and myeloma, with numerous subtypes. the general symptoms of leukemia are fatigue, increased susceptibility to infection, bleeding, and the formation of bruises easily. typical lymphoma symptoms are night sweats and involuntary weight loss, recurrent fever, fatigue, and itching. myeloma patients often have bone pain, fatigue, anemia, hypercalcemia or infection symptoms. adverse effects of hematologic malignancies and treatments cause abnormality in physical function and quality of life. treatments such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation, which may have side effects on the body systems are used in early or late period. the most common side effect due to chemotherapy is fatigue. vomiting, weight loss, anemia, depression, decreased aerobic capacity, loss of muscle strength, decreased physical functioning and deterioration in the quality of life are indirect side effects seen in patients. in the literature, side effects of hematological malignancies have been investigated after treatment in patients. however, no study investigated exercise capacity, quality of life, physical activity level and pulmonary functions on newly diagnosed hematologic malignant patients. therefore, the investigators aimed to compare aforementioned outcomes in newly diagnosed hematologic malignant patients and healthy controls.

according to sample size calculation 30 newly diagnosed hematologic malignant patients and 30 healthy individuals will be included. before treatment submaximal exercise capacity, physical activity, quality of life, pulmonary functions, respiratory and peripheral muscle strength, respiratory muscle endurance, dyspnea and fatigue perception, anxiety and depression will be evaluated. primary outcome measurements are exercise capacity, physical activity, quality of life, secondary outcomes are respiratory and peripheral muscle strength, respiratory muscle endurance, pulmonary functions, dyspnea and fatigue perception, anxiety and depression.

Eligibility criteria:
inclusion criteria: * newly diagnosed hematological malignant patients * 18-65 years of age * under standard medications. exclusion criteria: * having cognitive disorder, * orthopedic or neurological disease with a potential to affect functional capacity, * comorbidities such as asthma, chronic obstructive pulmonary disease (copd), acute infections or pneumonia, * problems which may prevent evaluating such as visual problems and mucositis * having metastasis to any region (bone etc.) * having acute hemorrhage in the intracranial and / or lung and other areas * having any contraindication to exercise training

Keywords: exercise capacity physical activity quality of life pulmonary functions muscle strength respiratory muscle strength respiratory muscle endurance dyspnea anxiety fatigue
caloric titration method of weight loss and maintenance

Conditions: Healthy

Summary: study examined the effectiveness of daily self-weighing to prevent age related weight gain.

were given scales to weigh themselves daily. change in weight was measured at the beginning and end of the two year observation period.

Eligibility criteria:
inclusion criteria: * over the age of 18 * not pregnant * not trying to gain or lose weight exclusion criteria: * diabetes * history of an eating disorder * body mass index (bmi) greater than 27.0 kg/m2.