Kornimate/medical-research-clean huggingface dataset:
prevalence of sexually transmitted infections (stis) in hiv-infected patients

Conditions: HIV Infections; Neisseria Gonorrhoeae; Chlamydia Trachomatis; Herpes Simplex

Summary: there has been an increase in incidence in sexually transmitted infections in hiv infected patients in the last years. in this study the investigators will prospectively evaluate the prevalence of symptomatic and asymptomatic infections with n. gonorrhea and ch. trachomatis as well as the seroprevalence of herpes simplex type 2 infection in hiv-infected patients attending the clinic for infectious diseases at the berne university hospital. in addition, participants will be asked to fill out a questionnaire on sexual behaviour and sexual health. study hypothesis: sti prevalence is high in certain risk-groups to justify screening in regular intervals.


Eligibility criteria:
inclusion criteria: * hiv-infection * attending the clinic for infectious diseases from may 09 to november 09 * sexually active during the last 12 months * written informed consent exclusion criteria: * none

Keywords: hiv-infection neisseria gonorrhea chlamydia trachomatis herpes simplex virus prevalence
effectiveness of digital physiotherapy in the short and long-term management of lower extremity lymphedema

Conditions: Lower Extremity Lymphedema

Summary: this study investigated the short- and long-term effects of digital physiotherapy in patients with unilateral and bilateral lower extremity lymphedema. limb volume and quality of life were assessed at baseline, post-treatment, and 12-week follow-up.

this study evaluated the feasibility and effectiveness of a digital physiotherapy program based on combined decongestive therapy in patients with lower extremity lymphedema. after an initial face-to-face training session on self-bandaging, self-manual lymphatic drainage, breathing exercises, and skin care, patients followed a 4-week digital physiotherapy program with remote supervision. compression stockings were used during the maintenance phase. limb volume was measured using circumference method. quality of life was assessed with the lymphoedema functioning, disability and health questionnaire questionnaire. assessments were repeated post-treatment and at 12-week follow-up.

Eligibility criteria:
inclusion criteria: * diagnosed with unilateral lower extremity lymphedema (either primary or secondary) * patients aged 18 years or older exclusion criteria: * presence of metastatic disease * history of coronary heart disease, pulmonary disease, or acute infection of any cause * presence of peripheral neuropathy

Keywords: lower extremity lymphedema digital physiotherapy combined decongestive therapy
direct evaluation of postoperative myocardial injury using coronary computed tomography angiography after non-cardiac surgery

Conditions: Postoperative Myocardial Injury

Summary: this is a prospective study in patients who undergo routine postoperative troponin assessment after major (semi-)elective noncardiac surgery. two groups are created based on postoperative troponin levels: postoperative myocardial injury (pmi) group with troponin i levels ≥ 60 ng/l and a control group with troponin levels \< 60ng/l. the primary aim of this study is to assess the association of pmi with pulmonary embolism. additionally, the association between pmi and obstructive cad will be investigated.


Eligibility criteria:
inclusion criteria: * ≥ 60 years old * major noncardiac surgery, defined as non-cardiac surgical procedures requiring hospital admittance \> 24 hours * semi-elective surgery, defined as surgery that that has been preceded by a preoperative evaluation. * ≥ 1 troponin assessment in the first 3 postoperative days as a part of the routine 'postoperative troponin assessment' protocol. * for patients who undergo surgery more than once, the first surgery will be included in the analysis. reoperations will not be included. exclusion criteria: * typical anginal complaints * acute st-elevation myocardial infarction (stemi) or new left bundle branch block (lbbb) on ecg * patients unable to fully comply to study needs (e.g. incompetent patients or patients unable to communicate in dutch or english) * severe claustrophobia. * patients who have a life expectancy of less than three months. * patients who are too ill to undergo a ccta or ventilation/perfusion (v/q) scan.

Keywords: troponin coronary artery disease pulmonary embolism computed tomography angiography postoperative myocardial injury
a study of the istent in combo with cataract surgery in newly diagnosed open angle glaucoma or oh patients.

Conditions: Open-Angle Glaucoma

Summary: the purpose of this study is to evaluate the safety and efficacy of the istent trabecular micro-bypass stent in reducing intraocular pressure (iop) in subjects with newly diagnosed open-angle glaucoma and subjects diagnosed with ocular hypertension.

the study will compare the reduction in iop of those subjects implanted with two glaukos micro-stents with the reduction in iop for patients receiving only primary medical therapy (xalatan - latanoprost) or cataract surgery alone. both groups will undergo routine cataract surgery.

Eligibility criteria:
inclusion criteria: * newly diagnosed with open-angle glaucoma (oag) or ocular hypertension with subjects not yet taking any glaucoma medications or recently diagnosed with mild open-angle glaucoma and are currently being treated with up to 2 glaucoma medications. * all subjects must need cataract surgery. exclusion criteria: * angle closure glaucoma * secondary glaucomas except pseudoexfoliative and pigmentary; no neovascular, uveitic or angle recession glaucoma * prior glaucoma procedures (eg trabeculectomy, viscocanalostomy, alt, slt, shunt implant, collagen implant, cyclo destructive procedures etc) * fellow eye already enrolled

Keywords: open angle glaucoma surgery cataract
management arterial hypotension during planned caesarean section, intravenous ephedrine/phenylephrine mixture versus intravenous baby noradrenaline

Conditions: Hypotension

Summary: comparison of two practices of obstetrical services between the chu of clermont ferrand and the hfme lyon-bron in the management of arterial hypotension during an elective cesarean section

the investigators propose to carry out a bicentric strict observational prospective study between the maternity of the hfme of lyon-bron which uses the mixture ephedrine / noradrenaline with the pse for many years in service protocol for the management of hypotension for cesarean section under perimedullary anesthesia and the chu of clermont-ferrand which uses baby noradrenaline 10 mcg/ml pse for this same indication according to an institutional protocol. patients corresponding to the inclusion and non-inclusion criteria will be recruited by a physician investigator and will give their agreement of non-opposition after having received clear oral and written information about our study. the care will not be modified in any way compared to the usual practices of the service.

Eligibility criteria:
inclusion criteria: * elective caesarean * ≥ 18 years old * term ≥ 36 weeks amenorrhea exclusion criteria: * contraindication of local anesthetics * contraindication of spinal anesthesia * patient's refusal * patient doesn't talk french * patient not covered by the social security system

Keywords: cesarean spinal anesthesia hypotension norepinephrine ephedrine phenylephrine sympathetic block
effect of stellate ganglion block combined with facial nerve block on the treatment of idiopathic facial paralysis

Conditions: Peripheral Facial Palsy

Summary: peripheral facial palsy is caused by damage to the facial nerve at any site of the peripheral branches after the facial nucleus.stellate ganglion block is performed to treat peripheral facial palsy because it increases blood flow and promotes nerve regeneration.facial nerve block worked with elimination of local inflammation of nerve and oppression. facial nerve block is a treatment that inject drugs into the damaged nerve around to eliminate local inflammation and compression of the nerve.


Eligibility criteria:
inclusion criteria: diagnosed by clinical and neurological assessment as one-sided simple facial * age 18 to 75 years * hbgs above ⅳ * the course of ifp not over 7 days. exclusion criteria: * coagulation dysfunction * plate plate plate shape, quantity or abnormal function * mental system diseases * gillan-bahrain syndrome * cancer, mumps, shingles infection, jaw facial pus lymph nodeitis, encephalitis, -cerebral hemorrhage and other diseases * local infection or systemic infectious disease at the puncture site * can not accept to nerve block

Keywords: peripheral facial palsy stellate ganglion block facial nerve block
myocardial injury following elective direct current cardioversion for atrial arrhythmias

Conditions: Cardioversion

Summary: researchers are trying to determine if heart injury occurs in subjects who undergo direct current cardioversion.

external transthoracic direct current (dc) cardioversion is a commonly used method of terminating cardiac arrhythmias. conventional wisdom indicates that external dc cardioversion causes myocardial injury. previous research has shown that dc cardioversion resulted in myocardial injury as evidenced by increased levels of cardiac troponin, even though those changes were modest. many of these studies evaluated monophasic defibrillators and older, less sensitive cardiac troponin assays. the current standard is now to use modern biphasic defibrillators and new high sensitivity cardiac troponin assays (hs-ctnt). it is conceivable that the newer defibrillators may not cause myocardial injury. it would be important to understand if myocardial injury occurs in this setting and its approximate magnitude as it would the interpretation of hs-ctnt values in patients and therefore influenced diagnoses. it may be if a threshold energy level can be identified that is would also influence the choice of energy used to deliver the shock in this situation. a previous preliminary study documented no evidence of myocardial injury after elective dc cardioversion with modern day defibrillators. we aim to validate and expand that study here at mayo clinic rochester.

Eligibility criteria:
inclusion criteria: * patients who are undergoing elective direct current cardioversion, either externally or via the patient's internal cardioverter-defibrillator exclusion criteria: * patients under age 18 * patients with myocardial infarction, coronary artery bypass grafting or any invasive cardiac procedure in the previous six weeks * pregnant patients * patients who cannot provide informed consent because of cognitive dysfunction
a trial of daily ultraviolet therapy to reduce cardiovascular risk factors

Conditions: Hypertension

Summary: the investigators have shown that a single dose of ultraviolet irradiation (as found in sunlight) will lower blood pressure for around one hour. they are now testing whether daily uva for two weeks will produce a sustained fall in bp in patients with high blood pressure. they will also measure the effect of daily uva on other cardiovascular risk factors.

epidemiological studies suggest that sunlight reduces all cause mortality, and particularly cardiovascular mortality. the investigators have previously shown vasodilatation and a transient fall in blood pressure following irradiation of human volunteers with 2 standard erythemal doses of uva radiation. this was independent of vitamin d and temperature rise and correlated with a nitric oxide synthase independent mobilisation of no stores from the skin to the systemic circulation. in this randomised, sham-controlled, cross-over double blind study, they will measure whether twice daily uva administration can produce a sustained fall in bp and other cardiovascular risk factors in a cohort of pre-hypertensive patients.

Eligibility criteria:
inclusion criteria: * pre-hypertensives (bp 120-139/80-89). * fitzpatrick skin types 2 and above (i.e. the ability to tan) exclusion criteria: * history of skin cancer. * fitzpatrick type 1 skin (always burns, never tans). * red hair. * family history of melanoma in first degree relative. * atypical naevus syndrome. * planned holiday or foreign travel during and for 4 weeks before the period of the study. * concurrent administration of: * anti-hypertensive medication, * photosensitising medication, * systemic immunosuppressive medication.

Keywords: hypertension ultraviolet
promoting self care to prevent urinary incontinence (ui): a four-year follow-up

Conditions: Urinary Incontinence; Bladder Control

Summary: this study examined whether self-efficacy promoted adherence to pelvic floor muscle training (pfmt) and bladder training (bt) in women aged 55 and older.

the study was designed to determine the capacity of self-efficacy to predict maintenance of the practices of pfmt and bt. women in the treatment arm of the rct attended a bladder health class (pfmt \& bt) to prevent ui. the class content emphasized self-efficacy. at 3-months post intervention the self-efficacy of participants was measured; these results were collected to analyze for predictive capacity of training adherence. for four years participants in both the treatment and control (no class) arms were followed with both questionnaires and 3-day bladder diaries (2/year) and clinic evaluations of (1/year). in addition, qualitative analyses of the narratives of bladder health class participants identified individual attitudes and strategies that either facilitated or deterred adherence.

Eligibility criteria:
inclusion criteria: * women aged 55 years or older who report 5 or fewer episodes of ui / year, no prior treatment for ui, no neurological disease, no difficulties performing activities of daily living exclusion criteria: * less than 55 years old, ui episodes greater that 5 per year, score of less than 24 on mini mental status examination

Keywords: urinary incontinence self efficacy pelvic floor muscle training bladder training
study on the efficacy and safety of low-dose ctx as maintenance therapy for mm unsuitable for transplantation

Conditions: Newly Diagnosed Multiple Myeloma

Summary: the investigators will conduct randomized and controlled clinical studies in order to preliminarily explore the efficacy and safety of low-dose cyclophosphamide and lenalidomide in maintenance therapy for mm that is not suitable for transplantation in the standard-risk group.

the investigators will conduct randomized and controlled clinical studies to preliminarily explore the efficacy and safety of low-dose cyclophosphamide in maintenance therapy for mm that is not suitable for transplantation in the standard -risk group. standard risk group mm patients who achieve vgpr or above after initial induction and consolidation therapy will use cyclophosphamide or lenalidomide as maintain therapy for 2 years.

Eligibility criteria:
inclusion criteria: 1. after induction and consolidation therapy (8 courses of chemotherapy), mm patients in the standard-risk group who were initially unsuitable for transplantation achieved a therapeutic effect of vgpr or above; 2. secretory mm with measurable indicators; 3. age ≥ 18 years old, gender unlimited; 4. no obvious dysfunction of heart, lungs, etc. (≤ grade i); 5. general kps ≥ 70% (excluding those caused by pathological fractures and bone pain). exclusion criteria: 1. cytogenetic high-risk patients; 2. recurrent or refractory mm; 3. using autologous hematopoietic stem cell transplantation as a consolidation therapy; 4. the therapeutic effect did not reach vgpr or above before enrollment; 5. asymptomatic mm; 6. no measurable indicators; 7. kps\<50%(excluding those caused by pathological fractures）； 8. dysfunction of heart, lungs, etc. (\> grade i); 9. unable to cooperate in observing adverse reactions and therapeutic effects; 10. pregnancy, breastfeeding, or refusal of contraception by women; 11. there is drug abuse and medical, psychological, or social conditions that may interfere with patients participating in research or evaluating research results; 12. any unstable or potentially endangering patient safety and compliance with the study.
effects of tourniquet use on physical function and performance in primary total knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: background: osteoarthritis (oa) is the most common joint disease that causes symptomatic health problems in the elderly population. for some patients with knee oa, total knee arthroplasty (tka) may be the only option that offers the possibility of reestablishing the patient's life quality. surgery of tka usually takes place in a complete bloodless field established by a tourniquet around the thigh. the method aims to reduce blood loss and give the surgeon better visibility during the operation. the method is, however, not without side effects as patients often experience severe pain and swollen leg in the time after surgery. furthermore, has the method shown decidedly muscle- and nerve damage followed by prolonged rehabilitation and reduced physical function. it is, however, possible to perform the operation without the use of the tourniquet. aim and hypothesis: the aim of the present study is to assess the effects of tourniquet use in tka on physical function, early rehabilitation, pain and opioid consumption. hypotheses h1: tka without tourniquet leads to better physical function and early rehabilitation. h2: tka without tourniquet causes less pain and opioid consumption h3: recovery of mechanical lower limb function post tka is faster without use of tourniquet. methods: 80 patients (40 in each group) all eligible for tka will be consecutively recruited and randomized to a) tka without tourniquet, b) tka with tourniquet. subjects will be evaluated before the operation (baseline) and 14 days, 3, 6 and 12 months after the operation. the primary outcome will be the change from baseline to 3 months in self-administered knee-function (koos-adl subscale). further, will we examine a number of pre-specified secondary outcomes, which include self-rated knee-related pain, symptoms, difficulty with sports and leisure activities, and quality of life. in addition, muscle function, physical performance, and the use of pain medication will be studied impact of the project: the project design of this study will enable analyses for determining the impact of operating without tourniquet and whether such an intervention can in fact improve physical function, performance and quality of life within tka patients. the results may impact notably on the patient level and possible redefine current surgical strategies. the societal perspective of the project is to remobilize patients faster, which may reduce hospital services and absence from work.


Eligibility criteria:
inclusion criteria: * knee osteoarthritis both clinically and radiologically according to the "ahlbäck classification system". * patients who can tolerate spinal anesthesia exclusion criteria: * patients with rheumatoid arthritis. * patients with bmi \> 35. * history of major knee operations. * malignancy. * known muscle disease. * history of deep vain thrombosis (dvt), or other blood coagulation disorders. * symptomatic bilateral oa, with planned surgery of the contra lateral knee within a year.
levosimendan in acute heart failure following acute myocardial infarction.

Conditions: Myocardial Infarction; Heart Failure; Cardiogenic Shock

Summary: the purpose of this study is to determine the safety and efficacy of a 24 hour infusion with levosimendan in patients with acute myocardial infarction and heart failure after acute percutaneous coronary intervention (pci) treatment.

double blind placebo-controlled study with parallel groups in patients with acute pci treated myocardial infarction complicated with decompensated heart failure. the study include a prospectively defined subgroup of patients in cardiogenic shock. treating acute myocardial infarction with pci restores blood flow, but decreased contractility remains for hours and days due to stunned myocardium. levosimendan has both inotropic and vasodilatory effects which could support the failing heart after treating the acute myocardial infarction with pci and may improve myocardial stunning and decrease pro-inflammatory cytokines. levosimendan could improve myocardial contractility, symptoms and outcome without adverse effects. the aims of the study are to investigate whether a 24 hour infusion with levosimendan could improve regional contractility measured by echocardiography, improve bnp levels, reduce the levels of pro-inflammatory cytokines and improve symptoms in patients with acute decompensated heart failure during the first 24 hours after acute pci.

Eligibility criteria:
inclusion criteria: * acute st-elevation myocardial infarction subject to acute pci or non-st elevation myocardial infarction subject to pci within 72 hours after start of chest pain and: * revascularization by pci, * signs of decreased wall-motion in at least 3 of 16 segments of the left ventricle * dyspnoea at rest and one of the following: pulmonary edema, pulmonary congestion,need for cpap or ventilator, need for ic diuretics or oliguria. subgroup of patients in cardiogenic shock: systolic bp below 90 after 1 hour of volume therapy. exclusion criteria: * age below 20 years * heart rate above 120 bpm * septic shock * ards * creatinine \>450 micromol/l * hepatic impairment * significant mechanical outlet obstruction * allergy against study drug medication * anaemia (hb \<8 g/dl) * pregnancy
accuracy of navigation in placement of sacroiliac screw

Conditions: Hip Fracture

Summary: the purpose of this study is to compare the precision of computer-assisted navigation for hip screw implantation to conventional fixation without navigation.

standard treatment for sacroiliac dislocations and sacroiliac fractures is placement of two screws through the iliosacral joint into the sacral ala or the body of the s1 vertebra. correct positioning is technically demanding. screw displacement may reduce the strength of fixation and lead to neurological complications. secondary objectives of the study are to compare the fluoroscopy time, complications and surgery duration between the treatments.

Eligibility criteria:
inclusion criteria: * radiologically confirmed sacroiliac dislocation or sacroiliac fracture * sacroiliac arthritis * age 18 years and more * written informed consent by patient or his/her legal representative exclusion criteria: * poor life expectancy (\<3months) * fracture of pathologic origin * history of substance abuse (recreational drugs, alcohol)within 12 months prior to screening * prisoner * currently involved in another study that precludes or complicates participation * disease or condition that would preclude accurate evaluation (e.g., significant psychiatric disease)