Kornimate/medical-research-clean huggingface dataset:
the effect of pemf for patients with quadriceps muscle weakness after aclr

Conditions: Anterior Cruciate Ligament Injuries; Quadriceps Muscle Atrophy

Summary: in hong kong, over 3000 anterior cruciate ligament reconstructions (aclr) are performed each year in order to restore knee function after an acl injury. the ultimate goal of aclr is to fulfil the return-to-play (rtp) criteria. despite successful surgery and a demanding rehabilitation process, some athletes still fail to comply to rtp. for those who achieve rtp, 23% of those who return to their sports would suffer a second acl injury. quadriceps muscle strength is one of the key determinants for a patient's successful return- to-play after aclr. quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. therefore, there is need to find a more effective way to increase quadriceps strength. there are emerging evidences showing that pulsed electromagnetic field (pemf) can modulate mitochondrial activities for muscle gain. pemf exposure on top of regular exercise training may promote muscle regeneration and tissue healing. this study aims to conduct a double-blinded, randomized controlled trial to investigate the effects of pemf treatment during the late postoperative period on quadriceps muscle strength in acl injured patient. muscle endurance could only be investigated in late postoperative period. the investigators hypothesize that pemf treatment is effective to reduce muscle weakness and promote gain in quadriceps muscle strength in aclr patients. based on the aim of this study, adult patients (aged 18-30) with a unilateral acl injury, total quadriceps muscle volume is equal or morn than 7% deficit on involved leg compared with uninvolved leg, sporting injury with a tegner score of 7+, both knees without a history of injury/prior surgery will be recruited. to estimate the improvement of patients, isokinetic muscle assessment, ultrasound imaging and mri for quadriceps muscle thickness, self-reported outcomes with questionnaires, kt-1000 for knee laxity and biomechanical analysis, xtreme ct for bone mineral density will be performed. to investigate the mechanism of pemf therapy on increasing quadriceps strength, samples of blood serum will be draw before and after intervention.


Eligibility criteria:
inclusion criteria: 1. aged 18-50 with a unilateral acl injury 2. sporting injury with a tegner score of 7+ 3. lsi for quadriceps strength \<70% of the contralateral leg at 4 months post-up 4. both knees without a history of injury/prior surgery exclusion criteria: 1. ages smaller than 18 years old or greater than 50 years old 2. any concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-op 3. preoperative radiographic signs of arthritis 4. metal implants that would cause interference on mri 5. non-hs graft for aclr 6. patient non-compliance to the rehabilitation program 7. pregnancy or possibility of pregnancy

Keywords: pulsed electromagnetic field pemf quadricep strength acl aclr
the role of gip in postprandial splanchnic blood flow distribution and metabolism in patients with type 2 diabetes

Conditions: Blood Flow

Summary: this project will describe the mechanisms of action and the relative contributions of gip to changes in gastrointestinal blood flow induced by oral glucose and endogenous gip with the use of a receptor antagonists gip(3-30)nh2 in patients with type 2 diabetes.

each participant will attend four independent randomised experimental days in the mri-scanner with intravenous infusion (hormone/placebo) and oral ingestion (glucose/water): an intravenous infusion of saline or gip(3-30)nh2 starts at time point -20 minutes.the infusions are combined with an oral glucose tolerance test (75 gram of glucose dissolved in 250 ml water ingested orally) at time point 0 minutes on two of the experimental days (with and without gip(3-30)nh2). mri measurements are repeatedly performed and blood samples are drawn to be analysed for endocrine responses from the intestines, pancreas, and bones.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * bmi 20-35 kg/m\^2 * age 20-80 exclusion criteria: * not mri-compatible implants * claustrophobia * abnormal kidney or liver function * anemia * planned weight loss or change in diet * hypertension * other conditions that could be expected to affect the primary or secondary outcomes

Keywords: gut hormones gip physiology type 2 diabetes
european pathology laboratories and covid-19

Conditions: Clinical Practice During the COVID-19 Crisis

Summary: the infectivity of severe acute respiratory syndrome coronavirus 2 (sars-cov-2), notably when handling human samples, remains poorly understood, as well as the impact of the covid-19 pandemic in routine clinical and molecular pathology practice, and for personal working in pathology laboratories. this study evaluates the consequences of the covid-19 crisis in clinical and molecular pathology laboratories in europe mostly those orientated for diagnosis of thoracic diseases.


Eligibility criteria:
inclusion criteria: * laboratories following the covid-19 crisis
the effects of tap block on thiol/disulfide homeostasis and pain in laparoscopic gynecological surgery

Conditions: Pain, Postoperative; Oxidative Stress

Summary: in the study, it was aimed to compare patients who underwent laparoscopic gynecological surgery with and without tap block in terms of postoperative pain levels and thiol/disulfide homeostasis.

thiols are organic sulphur derivatives containing sulfhydryl residues (-sh) in their active regions. thiols easily react with oxygen containing free radicals to form disulfides. this is a defence mechanism against oxidative stress.7 an automated analysis quantitatively measuring serum native and total thiol, and disulfides has been recently described as a method to determine dynamic thiol/disulfide homeostasis (tdh).the role of dynamic thioldisulfide homeostasis has been increasingly shown in many diseases. there is a growing number of evidences that an abnormal thiol-disulfide homeostasis may play role in the pathogenesis of a variety of diseases such as cardiovascular disease, malignancies, rheumatoid arthritis, chronic kidney disease, and acquired immunodeficiency syndrome. laparoscopic gynecological surgery has several advantages when compared to open surgery, including faster postoperative recovery and lower pain scores. however, the possibility of significant postoperative pain remains. trocar placement, tissue dissection, and pneumoperitoneum formation contribute to postoperative pain in laparoscopic surgery. if this pain is not treated adequately, it can cause an increase in pain levels, nausea and vomiting, and as a result, a decrease in patient comfort and a prolongation of hospitalization. ultrasound-guided transversus abdominis plane (tap) block is easy to perform and has recently become a popular technique for reducing postoperative pain after abdominal surgery. it has been reported that it provides effective postoperative analgesia with a decrease in opioid consumption in various open abdominal surgical procedures and contributes to faster patient recovery. in the study, it was aimed to compare patients who underwent laparoscopic gynecological surgery with and without tap block in terms of postoperative pain levels and thiol/disulfide homeostasis.

Eligibility criteria:
inclusion criteria: * patients who have undergone laparoscopic gynecological surgery * patients who agreed to participate in the study exclusion criteria: * patients who did not agree to participate in the study * patients with missing data

Keywords: thiol/disulphide homeostasis tap block laparoscopic gynecological surgery
determinants of age-related treatment effectiveness in ovarian cancer

Conditions: Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer; Ovarian Diseases; Fallopian Tube Diseases; Peritoneal Diseases

Summary: while significant progress has been made in the treatment and prognosis of ovarian cancer, this progress has mostly shown benefits for younger women. this study aims to understand two things: how body composition (the amount of muscle and water versus fat in in the body) affects the dose and side effects of chemotherapy; and the biological reason for the worse prognosis with aging. to get a good view of these effects, investigators are asking the help of both younger and older women for this project.


Eligibility criteria:
inclusion criteria: * participants must have one of the following: a) histological or cytological diagnosis of high-grade serous ovarian, fallopian, or peritoneal cancer, stage iii or iv; b) in the opinion of investigator, highly suspicious stage iii or iv ovarian, fallopian, or peritoneal cancer (histologically confirmed non-serous ovarian, fallopian, and peritoneal cancers will be considered screening failures). * at least one biopsiable lesion by ct/us or laparoscopy. * have not received previous treatment for ovarian cancer. * life expectancy of greater than 6 months. * eastern cooperative oncology group (ecog) performance status \ 60%). * must have adequate organ and marrow function. * deemed eligible for neo-adjuvant chemotherapy with carboplatin and paclitaxel and surgery by their oncologist. * women of child-bearing potential must agree to use adequate contraception prior to study entry and for the duration of study participation. * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * active second malignancy within last 2 years (except non-melanoma skin cancer or in situ carcinomas. * prior treatment for ovarian cancer. * potential participants with known brain metastases will be excluded from this clinical trial. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin and paclitaxel. * known allergy to carboplatin, paclitaxel, or cremophor. * uncontrolled concomitant illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * women who are pregnant. breastfeeding should be discontinued if the mother is treated with carboplatin and paclitaxel. these potential risks may also apply to other agents used in this study. * hiv-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with carboplatin and paclitaxel or other agents administered during the study.

Keywords: high-grade serous cancer stage iii cancer stage iv cancer
performance evaluation of daily disposable contact lenses in habitual lens wearers who use digital devices frequently

Conditions: Myopia

Summary: the goal of this study is to compare the performance of two daily disposable silicone hydrogel lenses.

this study is prospective, bilateral eye, double masked, randomized, 1 week cross-over, daily wear design involving in two different daily disposable lens types. each lens type will be worn for approximately one week.

Eligibility criteria:
inclusion criteria: * is between 18 and 35 years of age (inclusively) and has full legal capacity to volunteer; * has read and signed an information consent letter; * self-reports having a full eye examination in the previous two years; * self-reports spending on most days at least 6 hours cumulative (not necessarily in one single stretch) using digital devices such as a computer, laptop, tablet, e-reader, smartphone; * anticipates being able to wear the study lenses for at least 8 hours a day, 7 days a week; * is willing and able to follow instructions and maintain the appointment schedule; * habitually wears soft contact lenses, for the past 3 months minimum; 1. no more than 1/3 of participants should be habitual wearer of myday or myday energys 2. no more than 1/3 of participants should be habitual wearer of acuvue® oasys max 1-day or acuvue® oasys 1-day. * has refractive astigmatism no higher than -0.75dc in each eye; * can be fit and achieve binocular distance vision of at least 20/30 snellen (available lens parameters are sphere -1.00 to -6.00d, 0.25d steps). exclusion criteria: * is participating in any concurrent clinical or research study; * has any known active ocular disease and/or infection that contraindicates contact lens wear; * has a systemic condition that in the opinion of the investigator may affect a study outcome variable; * is using any systemic or topical medications that in the opinion of the investigator may affect contact lens wear or a study outcome variable; * has known sensitivity to the diagnostic sodium fluorescein used in the study; * self-reports as pregnant, lactating or planning a pregnancy at the time of enrolment; * has undergone refractive error surgery or intraocular surgery.
assessing the impact of the microbiome on breast cancer radiotherapy toxicity

Conditions: DCIS; Invasive Breast Cancer

Summary: microorganisms in the human body (such as virus, bacteria, fungus) may have an important role in breast cancer side effects. in this study, microorganisms will be analyzed to determine which, if any,are present. it will then be determined if side effects from breast radiation are associated with these microorganisms. understanding the association of microorganisms with side effects will allow the study team to look at strategies to reduce side effects for patients undergoing radiation to the breast.

this study will prospectively enroll 50 participants with with biopsy proven ductal carcinoma in situ (dcis) or invasive breast cancer 18 years of age or older, undergoing breast conserving surgery and adjuvant radiation therapy at cleveland clinic. each participant will have a post-surgery pre-radiotherapy stool and breast skin sample obtained, complete a medical record review for clinical data, and have complete an interview/questionnaire in order to learn about potential risk factors which will be included in the data collection form. included information will include stage (t, n, m, composite), receipt of chemotherapy, radiation fields and dose, bmi, hypertension (htn), diabetes mellitus (dm), smoking status, history of breast infection yes/no (data collection form).

Eligibility criteria:
inclusion criteria: * breast cancer patients with dcis or invasive breast cancer * undergoing breast conserving surgery and adjuvant radiation * subjects must be willing and able to provide breast skin samples exclusion criteria: * active clinical breast infection (on antiobiotic for skin/breast infection or clinical diagnosis) * refuse or are unable to sign informed consent form * past history of breast cancer
a study of pegasys (peginterferon alfa-2a (40kd)) in patients with lamivudine resistant hbeag-negative chronic hepatitis b.

Conditions: Hepatitis B, Chronic

Summary: this single arm study will evaluate the efficacy and safety of pegasys in patients with lamivudine resistant hbeag negative chronic hepatitis b. patients will receive pegasys 180 micrograms s.c. weekly for 48 weeks; following this, there will be a 48 week period of treatment-free follow-up. the anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, 18-65 years of age; * hbeag negative chronic hepatitis b; * treated with lamivudine for \>=6 months; * demonstrated lamivudine resistance; * compensated liver disease. exclusion criteria: * severe hepatic dysfunction; * previous treatment with antivirals other than lamivudine; * immunosuppressant treatment in past 6 months; * co-infection with hepatitis a, c, or d virus or human immunodeficiency virus; * medical condition associated with chronic liver disease.
adopt-prestage: study evaluating the impact of the program prestage

Conditions: Cancer; Oral Anticancer Drugs

Summary: as the proportion of oral anticancer treatments is continuously increasing, adherence appears as a major issue for patients' outcomes. poor adherence affects particularly geriatric patients due among others to polypharmacy or cognitive impairment. thus, the need for educational programs in this population has been regularly emphasized. prestage educational program was built after an external and internal analysis of educational needs in elderly patients treated with oral cancer treatments. it implicates a multidisciplinary educational team (nurses, physicians, pharmacists, psychologists, physiologists, social workers...). six educational workshops were designed with the following endpoints: disease and treatment understanding, treatment management, nutrition and psychological as well as physical well being. adopt-prestage is a clinical, prospective, interventional, open-label, multicenter, randomized, controlled trial designed to evaluate the impact of prestage program. it is, to the investigators' knowledge, the first randomized controlled trial evaluating the acceptability and impact (adherence, clinical benefit) of an educational program in an elderly cancer population. the primary endpoint of this trial will be to evaluate adherence using an indirect objective adherence measure: the medication event monitoring system (mems). secondary endpoints include quality of life and evaluation of changes in patients' behaviors.


Eligibility criteria:
inclusion criteria: * patients older than 70 years, * for which oral anticancer therapy has been initiated within the previous 45 days or will be started within 45 days * for any type of cancer, solid or hematologic, any stage * estimated life expectancy\> 6 months * affiliation to social security or equivalent * patients who can answer questionnaires and protocol evaluations * informed consent signed by patients * domiciled within 50 km around the investigating center exclusion criteria: * for patients with breast cancer, exclusive treatment with hormone therapy * first-generation hormone therapy in prostate cancer * patient not available for regular follow-up whatever the cause (geographic, family, social, psychological) * any serious condition, ie serious physical or mental, leading to a disability permanent and likely to prevent the proper course of treatment * patient deprived of liberty or under guardianship

Keywords: therapeutic educational program adherence quality of life elderly cancer
the role of b7-h4 in tumor vaccine

Conditions: Glioma

Summary: glioma patients have poor prognosis because of limited choices of treatment. therapeutic cancer vaccines have been proved to improve survival in glioma, but resistance is a new challenge for vaccine treatment, and the mechanism is unclear. the applicant found in previous papers that glioma cells induced b7-h4 overexpression in macrophages, and the expression level of b7-h4 is highly correlated with vaccine resistance. preliminary experiments indicated that b7-h4 protein in macrophages inhibited the expression of atf3, stat1 and cxcl9/10, which also resulted in decreased t cell infiltration in glioma model of mouse and was a negative factor of vaccine benefits. therefore, the applicant hypothesize that b7-h4 inhibits stat1 transcription by reducing expression of atf3, resulting in decreased phosphorylated-stat1 in nucleus, which inhibiting expression and secretion of chemokines 9/10. thereby, reduced infiltration of t cells in microenvironment will be followed, which ultimately promotes resistance of vaccine treatment in glioma. the follow-up plan of this project will be conducted based on the cells, organoid platform and animal experiments to confirm the role and mechanism of macrophage-derived b7-h4 in secretion of chemokines for t cells and treatment resistance of vaccines. moreover, the dc vaccine produced by team of the applicant will be used to assess the probability of reversing vaccine resistance when intervening b7-h4 axis. finally, a model for evaluating clinical benefits from vaccine will be established based on data from clinical trials combining with expression of b7-h4 and clinicopathologic features. this study will provide new evidences for the treatment of cancer vaccines in gliomas.


Eligibility criteria:
inclusion criteria: inclusion criteria: the patients with glioma in the department of neurosurgery of huashan hospital affiliated to fudan university who meet the following three conditions can be enrolled 1. they were 18-80 years old, male and female; 2. the pathological results of frozen section during operation were gliomas; 3. tissue (6 mm \* 6 mm) can be used for cell sorting on the basis of not affecting clinical routine diagnosis; 4. sign informed consent. exclusion criteria: patients who meet any of the following criteria will not be included in this study: 1. participants in other clinical trials; 2. pregnant women.

Keywords: glioma treatment resistance immunotherapy cancer vaccine macrophage
study on the appropriateness of bariatric surgery in adolescents

Conditions: Morbid Obesity

Summary: single-center study carried out in order to evaluate in prospective among patients seen or treated in the pediatric endocrinology unit and multidisciplinary management of obesity, the potential number of patients eligible for surgery.

this is a feasibility study in order to file a subsequent national project as part of a phrc on bariatric surgery in adolescents.

Eligibility criteria:
inclusion criteria: * failure of weight loss in an organized care\> 6 months * bmi \> à 35 kg/m2 with presence of severe co-morbidities (diabetes, moderate or severe osas, intracranial hypertension, severe hepatic steatosis), which can be improved by a significant weight loss and sustainable or bmi \> or = 40 kg/m2 with less severe co-morbidities (hypertension, gerd) and may worsen the health status including reduced quality of life. * patients must have completed their growth (bone age \> 13 for girls and \>15 for boys). * the teenager and his legal representative must have given their informed consent. * the subject must be affiliated to a social security scheme exclusion criteria: * syndromic obesities * tumor-induced obesity * patient with severe psychiatric disorders * patient with eating disorders * patients under judicial protection * patient under guardianship or curatorship * patient participating in another study

Keywords: morbid obesity teenagers co-morbidities bariatric surgery epidemiology