Kornimate/medical-research-clean huggingface dataset:
study of endogenous inhibitory modulation during gastric and somatic stimulation

Conditions: Functional Dyspepsia

Summary: visceral hypersensitivity as evidence of central sensory sensitization is evident in many patients with functional disorders such as functional dyspepsia (fd) and irritable bowel syndrome (ibs). we recently demonstrated both somatic hypersensitivity and abnormal endogenous pain modulation in ibs, both of which indicate central sensitization as a crucial mechanism in ibs. endogenous pain mechanisms regulate, fine-tune and integrate sensory and homeostatic, including neuroendocrine, immune, motor and autonomic nervous system processes. hitherto, no studies have investigated the role endogenous pain modulation in fd. abnormal modulation could explain several of the symptom complexes associated with fd and provide a rationale for exploration of new treatments. the current study was designed to 1. investigate the gastric sensitivity in fd patients and healthy controls during gastric capsaicin stimulation 2. assess the endogenous pain inhibitory modulation system in fd patients and healthy controls during heterotopic stimulation


Eligibility criteria:
inclusion criteria: fd patients: * eighty male and female fd patients according to rome iii criteria (drossman, 2006), aged 18 to 70 years, will be recruited from primary and secondary care via advertisements and our referral networks. * fd discomfort or pain should be the most prominent symptom. * patients must have been off all fd and analgesic medication and any drugs potentially influencing sensory function for at least two weeks before study start and be able to remain off such medication for the duration of the study period. healthy controls: * forty male and female healthy volunteers, aged 18 to 70 years without any gastrointestinal pathology or history of significant abdominal pain, bowel disorders, bloating or discomfort during the last 3 months will be recruited. exclusion criteria: exclusion criteria for both fd patients and healthy controls: * organic gastrointestinal or other significant systemic disease, including cardiovascular, dermatological, psychiatric, neurological and endocrine diseases. patients with peptic ulcer scars are also excluded. * chronic or acute pain, except related to other functional syndromes (irritable bowel syndrome, chronic pelvic pain, fibromyalgia, migraine). * h. pylori positive. * abdominal surgery, including gastric resection or cholecystectomy (except appendectomy) * history of brain disease or brain surgery. * ongoing treatment with any drugs or need for drugs (or complementary medication) within last 14 days. * treatment with any investigational drug during the preceding 30 days. * ingestion of spicy, chilli pepper containing meal, or use of capsaicin skin cream in last 48 hours before start of study or any study day. * pregnancy or lactation. * no written informed consent obtained from subject.
pediatric dysphagia outcomes after injection laryngoplasty for type i laryngeal cleft

Conditions: Dysphagia; Aspiration; Quality of Life

Summary: type i laryngeal cleft evaluation and treatment in the pediatric population is an emerging science. the largest published series of pediatric patients with type i laryngeal clefts shows conflicting evidence in terms of outcomes, resolution of dysphagia and method of treatment. a comparison of quality of life outcomes before and after injection laryngoplasty has not been carried out. the investigators hypothesize that injection laryngoplasty significantly improves symptoms and quality of life related to dysphagia in a pediatric population with laryngeal clefts.

dysphagia with aspiration is a common disorder in the pediatric population. aspiration with feeds is diagnosed on modified barium swallow studies and patients are referred to the pediatric otolaryngologist to assess the airway for a possible laryngeal cleft. type i laryngeal cleft can lead to dysphagia and aspiration in young children. however, diagnosis of type i laryngeal cleft can be difficult and subjective at microlaryngoscopy in the operating room. type i laryngeal cleft evaluation and treatment in the pediatric population is an emerging science. the largest published series of pediatric patients with type i laryngeal clefts shows conflicting evidence in terms of outcomes, resolution of dysphagia and method of treatment. it is generally recommended to do an injection laryngoplasty at the time of airway evaluation as a diagnostic and therapeutic measure. improvement in symptoms supports the diagnosis and can serve as either definitive treatment with repeated injections or as a preemptive treatment in preparation for surgical repair. a comparison of quality of life outcomes before and after injection laryngoplasty has not been carried out. thus, the aim of this study is to determine if injection laryngoplasty improves symptoms and quality of life related to dysphagia in a pediatric population with laryngeal clefts.

Eligibility criteria:
inclusion criteria: * chief complaint of dysphagia and/or aspiration detected on a clinical swallow assessment and/or modified barium swallow study * able to withstand general anesthesia and direct microlaryngoscopy in the operating room exclusion criteria: * inability or parent refusal to undergo procedure under general anesthesia in the operating room

Keywords: dysphagia aspiration pediatric injection laryngoplasty
effect of melatonin on feeding intolerance and incidence of necrotizing enterocolitis in preterm infants

Conditions: Preterm Infant; Feeding Intolerance; Necrotizing Enterocolitis

Summary: assesses the efficacy of melatonin in treatment of feeding intolerance in preterm infants, the time needed to reach full enteral intake, the incidence of necrotizing enterocolitis and measures the level of tumor necrosis factor-alpha as a marker of oxidative stress.

this is a prospective study held on ninety preterm infants in ain shams university neonatal intensive care units. all enrolled neonates were suffering from feeding intolerance in the form of abdominal distension, gastric residuals or bloody stools. the first group of forty five infants were given melatonin in addition to traditional antibiotic treatment. the second group of forty five infants were given traditional antibiotic treatment only. both groups were followed up clinically as regards improvement of clinical signs of feeding intolerance and laboratory results till they reached full enteral intake. both groups were compared as regards incidence of necrotizing enterocolitis and level of tumor necrosis factor-alpha after 72 hours of starting treatment as a marker of oxidative stress.

Eligibility criteria:
inclusion criteria: * preterm infants (\<37 weeks of gestation) * evidence of feeding intolerance exclusion criteria: * infants with hypoxic ischemic encephalopathy * infants on nothing per os * infants with high oxygen needs wither on invasive or non-invasive mechanical ventilation * major congenital anomalies * intracranial hemorrhage * respiratory distress syndrome
etiology of endocarditis in negative blood cultures

Conditions: Infective Endocarditis (IE)

Summary: infective endocarditis remains a serious disease that requires fast and specialized support in 2012. however, 24% of endocarditis unanswered etiology. the systematic use of new policy diagnosis, including (i) a systematic use of specific pcr techniques and (ii) the search for markers of inflammatory and tumoral diseases, should increase the number of positive etiological diagnosis of culture-negative samples. secondly, because of the seriousness of the disease, the investigators were led to develop a new score: score for admission. this score, realized in less than 4 hours from the admission of the suspected patient with endocarditis, should allow for immediate probabilistic antibiotic treatment after completion of the diagnostic kit. the modified duke score give its results in 4 to 7 days. with the score of admission thus diagnostic processes are accelerated and, where appropriate, empirical antibiotic therapy started. primary: evaluate the effectiveness of the new diagnostic strategy on etiological identification of endocarditis. secondary: validate the "admission" score compared to the modified duke score.


Eligibility criteria:
inclusion criteria: * patient with endocarditis diagnostic kit prescribed * patient is more than 18 years old * patient who freely signed written informed consent. * patient affiliated to a health assurance exclusion criteria: * minor patient (\<18 years) * patient pregnant or breastfeeding * patient incapable or unable to consent * private patient of liberty or under court order * patient refusing to participate in the research
liquid biopsy-based novel modality for postoperative management of lung cancer

Conditions: Non-small Cell Lung Cancer; Minimal Residual Disease; Adaptive Treatment

Summary: the goal of this study is to develop new techniques for minimal residual disease(mrd) monitoring and to confirm the efficacy and safety of mrd-guided postoperative management for early stage non-small cell lung cancer. the main questions this study aims to answer are: * how to develop multi-omics-based high-sensitivity detection methods to accurately capture mrd and monitor postoperative recurrence in lung cancer? * is adaptive treatment guided by ctdna-mrd for lung cancer patients superior to traditional clinical management and effectively improves survival? * do heterogeneous patient populations (grouped by stages, histopathological subtypes, driver mutations, and treatment histories) show differences in effects under ctdna-mrd guided postoperative management strategies?

approximately 30% of early-stage lung cancer patients experience recurrence after curative surgery. however, the clinical utility of routine chest ct surveillance remains limited. emerging evidence has demonstrated that liquid biopsy-based minimal residual disease (mrd) detection may serve as a more sensitive monitoring strategy. longitudinal ctdna dynamics analysis further enables real-time assessment of tumor progression and early detection of molecular relapse. this study aims to develop a novel multidimensional approach for non-invasive postoperative recurrence monitoring in lung cancer and establish an mrd-guided adjuvant therapy model to optimize precision treatment and mrd-stratified follow-up protocols for lung cancer patients. this study will evaluate the sensitivity and specificity of novel monitoring methods and further compare emerging non-invasive recurrence monitoring approaches with conventional ctdna-based techniques, driving continuous advancements in lung cancer research.

Eligibility criteria:
inclusion criteria: * non-small cell lung cancer with stage ia-iiia (8th edition tnm classification) planning to undergo curative surgery or to undergo neoadjuvant therapy * solid nodules \>1 cm or ground-glass nodules \>1.5 cm on imaging * no history of malignancies other than non-small cell lung cancer in the past 5 years * specimens are well preserved and imaging documents are accessible. exclusion criteria: * age\<18 years old * non-small cell lung cancer with pathologic stage iiib-iv (8th edition tnm classification) * pathology results confirmed not to be non-small cell lung cancer * history of malignancies other than non-small cell lung cancer in the past 5 years
efficacy of oral dexamethasone versus parenteral dexamethasone in the management of mild to moderate croup

Conditions: Laryngotracheobronchitis; Croup

Summary: croup (laryngotracheobronchitis) is a viral infection of the upper airway that causes throat swelling, leading to a barking cough, stridor, and hoarseness. it mainly affects children aged 6 months to 12 years, peaking at around 2 years. most cases are mild and self-limiting. emergency treatments include cool mist, nebulized epinephrine, and steroids. steroid therapy, particularly dexamethasone (oral or intramuscular), is commonly used, with recent studies suggesting intramuscular dexamethasone may be more effective. however, most research has focused on hospitalized patients, and there is a lack of local data for mild cases. this study aims to address that gap and improve patient counseling and future research


Eligibility criteria:
inclusion criteria: * patient age 2 to 12 years * both genders * diagnosed with croup as operational definitions exclusion criteria: * patients with chronic pulmonary disease like tuberculosis, * allergy or contraindication of corticosteroid (history of tuberous sclerosis, history of varicella infection during the past three weeks), to corticosteroids, * history of corticosteroid administration during the last four weeks, * foreign body * patients with immunodeficiency disorder
non-specific back pain and spinal manipulation

Conditions: Non-specific Back Pain

Summary: the main purpose of this study is to identify short-term predictors of positive responses to a spinal manipulation treatment. to do this, positive responses to treatment, characterized by improvement in pain score, functional capacity, as well as the global perceived change will be evaluated using single and multiple logistic regressions in which biomechanical variables, comfort, expectation will used as potential predictors.

the main purpose of this study is to identify short-term predictors of positive responses to a spinal manipulation treatment. to do this, positive responses to treatment, characterized by improvement in pain score, functional capacity, as well as the global perceived change will be evaluated at baseline and at 7 days. pain score will be also assessed every day with text-tracking. global perceived change will be evaluated using single and multiple logistic regressions in which biomechanical variables, comfort, expectation will used as potential predictors. 100 individuals with a history of non-specific back pain will be recruited in a chiropractic care center.

Eligibility criteria:
inclusion criteria: * being aged over 18 years old * presenting non-specific back pain (chronic \>=3 months or recurrent complaint) * speaking french or english exclusion criteria: * symptomatic thoracic pain * non-musculoskeletal disorders pain * pregnancy * not eligible to spinal manipulation (if osteoporosis, vertebral fracture history, thoracic disk herniation)

Keywords: back pain spinal manipulation cohort study
the sort out ix stemi oct trial

Conditions: Acute Myocardial Infarction

Summary: the aim of the danish organization for randomized trials with clinical outcome (sort out) ix stemi oct is to compare early vascular healing of the polymer-free biolimus-eluting biofreedom stent with a biodegradable-polymer sirolimus-eluting orsiro stent in patients with st-segment elevation myocardial infarction (stemi) treated with primary percutaneous coronary intervention (pci).

sort out ix stemi oct is a randomized 1:1 study comparing the polymer-free biolimus-eluting biofreedom stent with a biodegradable-polymer sirolimus-eluting orsiro stent patients with stemi treated with primary pci. vascular healing index (uncovered stent struts, malapposed stent struts, maximal intima coverage and accumulated extra-stent lumen volume) assessed with optical coherence tomography (oct) 1 month after primary pci. patients will be enrolled by the investigators and randomly allocated to treatment groups after diagnostic coronary angiography and before primary pci. a web based trial partner randomization system will be used. oct will be performed with the frequency-domain optis oct system and dragonfly™ imaging catheter during the index procedure and after 1 months.

Eligibility criteria:
inclusion criteria: * patients aged 18 years or over with stemi, requiring treatment with a drug-eluting stent. exclusion criteria: * life expectancy of less than one year; an allergy to aspirin, clopidogrel, ticagrelor, prasugral, biolimus or sirolimus; participation in another randomized trial; chronic renal disease; or inability to provide written informed consent.

Keywords: drug eluting stents coronary vascular healing
mvp rct: mind and voice project randomized control trial

Conditions: Physical Health; Mental Health; Alcohol; Use, Problem; Interpersonal Violence

Summary: the study seeks to learn more about the health behaviors of young adults. health behaviors include relationships, physical and mental health, alcohol use, and conflicts with others. the purpose of this study is to improve prevention and intervention programs for young adults.


Eligibility criteria:
inclusion criteria: * prior alcohol use * interpersonal violence exclusion criteria: * person does not understand/speak english * prisoner or person being taken into custody/under house arrest * person or parent/guardian unable to give consent due to insufficient cognitive orientation due to unknown reasons * person unable to give consent due to insufficient cognitive orientation due to drug or alcohol use/ accidental overdose; given pain medications (fails mmse) * person diagnosed with schizophrenia * person is actively suicidal or being treated for self-harm (includes overdose with the intent to harm self - not accidental) * person being treated for child abuse situation * deaf or visually impaired/illiterate/can't speak * screened within last month or already in study * combative * patient died * too sick in emergency department to approach (e.g. - never stabilizes, in trauma bay, intubated, on ventilator, or a level 1 trauma) * person has already refused 2 times
a study of pf-03084014 in japanese patients with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: the purpose of this study is to determine the recommended phase 2 dose for pf-03084014 single-agent administration in japanese patients with advanced solid tumors. pharmacokinetics and the overall safety profile of pf-03084014 will also be evaluated.


Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of advanced solid tumors that is resistant to standard therapy or for which no standard therapy is available. * age ≥18 years. * ecog performance status (ps) must be 0 or 1. * adequate bone marrow function * adequate renal function * adequate liver function * resolved acute effects of any prior therapy to baseline severity or grade ≤1 exclusion criteria: * patients with known brain metastases * major surgery within 4 weeks of starting study treatment * radiation therapy within 2 weeks of starting study treatment * systemic anti cancer therapy within 2 weeks (4 weeks for antibody) of starting study treatment * previous high dose chemotherapy requiring stem cell rescue * prior irradiation to \>25% of the bone marrow * prior treatment with a notch signal inhibitor * known malabsorption syndrome or other condition that may impair absorption of study medication * any of the following in the previous 6 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism * current use or anticipated need for known strong and/or moderate cyp3a4 inhibitors * current use or anticipated need for known strong cyp3a4 inducers
generated ai-informed intervention (emohaa) vs group act vs wl on emotional distress

Conditions: Artificial Intelligence (AI); Depression - Major Depressive Disorder; Anxiety

Summary: emotional distress, such as anxiety and depression, is an essential issue worldwide. there have been several evidence-based psychotherapies that are effective in improving emotional distress, such as acceptance and commitment therapy (act). however, the scarcity of professionals and the imbalance in the distribution of mental health resources prevent individuals in need from accessing immediate and effective help. artificial intelligence (ai) has the potential to promote this problem. the existing studies have provided preliminary support for the application of ai in mental health interventions. one such model, emohaa, a generated ai model, has been examined for its effectiveness in adult emotional distress. however, despite the limited reliability of the single-group design, parallel randomized controlled trials are scarce to validate this finding further. this present study is to fill this gap. this study aims to examine the effectiveness of the generated ai (emohaa) in reducing emotional distress, including anxiety and depression, compared with group act and waitlist. in this parallel randomized controlled trial, it is hypothesized that (1) compared with the waitlist, emohaa and group act could significantly improve participants' emotional distress, including anxiety and depression symptoms; (2) emohaa would lead to a greater reduction in anxiety and depression symptoms compared with group act.


Eligibility criteria:
inclusion criteria: * adults with 18-25 ages; * suffering from emotional distress (phq-9 \> 9 or gad-7 \> 9); * ability to use the mobile phone to interact with ai; * consent to participate in the study. exclusion criteria: * high risk of self-injury and suicide; * presence of psychotic symptoms (i.e., delusions); * serious substance use problems; * other mental or physical illnesses requiring urgent medical assistance; * received other psychological or pharmacological interventions in the last month
neoadjuvant chemotherapy in non small cell lung cancer (nsclc) stages ib, iia, iib, and iiia/t3

Conditions: Non-small Cell Lung Cancer

Summary: randomised trial of chemotherapy or not before surgery in early resectable stages of nsclc (ib, iia, iib, and iiia/n2).

randomisation between 3 courses of neoadjuvant carboplatin plus paclitaxel or no chemotherapy before surgery.

Eligibility criteria:
inclusion criteria: * nsclc * stages ib, iia, iib, iiia/t3 * lung function test allowing surgery * age 18-75 years exclusion criteria: * poor lung function * performance status 3-4 * mediastinal lymph node involvement

Keywords: non-small cell lung cancer neoadjuvant resection