Kornimate/medical-research-clean huggingface dataset:
prevention of postoperative nausea and vomiting

Conditions: Postoperative Nausea and Vomiting

Summary: we designed this randomized, double- blind, single-center study to compare the efficacy of the combination of dexamethasone with ondansetron and dexamethasone with dimenhydrinate undergoing plastic surgery.

a total of 60 voman patient, asa status i-ii , aged 18-65 year and scheduled for elective rhinoplasty were enrolled in the study. exclusion criterias hypersensitivity or contraindication for the studied medications, received an antiemetic drug or steroid within 24 hours before anesthesia, have history of diabetes history of motion sickness (ms) or ponv, or pregnant and lactating females. patients were informed on how to use the patient controlled analgesia device during the postoperative period. the risk criterias for ponv were recorded for each patient.patients were randomly assigned to two study groups of 30 patients. all patients were premedicated with intravenous (iv) midazolam (1-2 mg). on arrival in the operating room, standard anesthetic monitors were applied. anesthesia was induced with iv propofol (2-3 mg/kg) and fentanyl (1-1.5 μg/kg). tracheal intubation was facilitated with rocuronium (0.6 mg/kg). after tracheal intubation all patient received iv 8 mg dexamethasone. normocapnic mechanical ventilation was performed after intubation. general anesthesia was maintained with sevoflurane (1 minimum alveolar concentration) in oxygen / air mixture and remifentanil (0.1-0.3 μg/kg/min) infusion.four mg ondansetron and for each patient 1 mg/kg dimenhydrinate in the 5 ml syringe solution were prepared by pharmacy department, and given to the blinded investigators. the patients, anesthesiologists (with the exception of the primary author), statistician, and observes were all blinded. dimenhydrinate was administered in group dd (1mg/kg), and ondansetron was administered in group do (4mg), and all patients received tramadol (1.5mg/kg) and tenoksikam (20mg) half an hour before emergence. postoperative analgesia was provided with a patient controlled analgesia system by using iv tramadol (5mg/ml) (2 ml bolus and 10 minutes lockout interval without basal infusion). after the surgery, muscle relaxation was reversed by administering neostigmine (0.05mg/kg) and atropine (0.015mg/kg). patients were extubated and transferred to the recovery unit.

Eligibility criteria:
criteria: inclusion criteria: 18 years to 60 years woman asa (american society of anesthesiologist) physical status i or ii patients undergoing laparoscopic gynecologic surgery or laparoscopic cholecystectomy exclusion criteria: hypersensitivity or contraindication to the study medications, antiemetic drug or steroid use within 24 hours before anesthesia, history of diabetes mellitus, history of motion sickness or postoperative nausea and vomiting, pregnancy, breast feeding
c1q/tnf-related proteins in coronary artery disease

Conditions: Coronary Artery Disease (CAD)

Summary: now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. recently, members of the c1q/tumor necrosis factor-related protein (ctrp) family have been reported to share structural homology with adiponectin. to date, 15 ctrp family members have been found that might play major roles in metabolism and inflammation. the investigators tried to clarify the relationship between ctrp family and coronary artery disease (cad) in korean men and women.

adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (cvd). adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. hypoadiponectinemia has been associated with an increased risk of coronary artery disease (cad) in several though not all studies. recently, a new family of secreted proteins, c1q/tnf-related protein (ctrp), was cloned on the basis of sequence homology with adiponectin. this family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. each ctrp family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. in the present study, we evaluated the role of ctrp in patients with cad and investigated whether ctrp family is significantly associated with cad prevalence after adjustment for well-known cad risk factors.

Eligibility criteria:
inclusion criteria: * 20\<age\<80 * history of stable angina, unstable angina, or acute myocardial infarction exclusion criteria: * a history of diabetes * stage 2 hypertension * malignancy * severe renal or hepatic disease
the impact of early mobilization protocol in patients in the icu

Conditions: Muscle Weakness; Quality of Life; Weaning Acceleration; ICU Length of Stay; Muscle Thickness of the Quadriceps Femoris

Summary: advances in intensive care and mechanical ventilation (mv) in the past two decades have increased critically ill patient survival. however, some patients require prolonged mv (pmv) and are deconditioned due to respiratory insufficiency caused by underlying disease, adverse effects of medications, and prolonged immobilization. patients in the intensive care unit (icu) are often confined to their beds, which results in inactivity, immobility, and severe osteomyoarticular system dysfunction. our hypothesis is that an early mobilization protocol improves muscle thickness (mt) of the quadriceps femoris, peripheral muscle strength, perceived functional status, gait speed, quality of life, duration of mechanical ventilation, icu length of stay of the critically ill patient. the purpose of this study is to evaluate the effects of implementation an early mobilization protocol in critically ill patients in the intensive care unit of the university hospital of santa maria.


Eligibility criteria:
inclusion criteria: * adults (18 years of age or greater) * patients in the first 24 hours of mechanical ventilation. * patients in the deep sedation will be evaluated by the richmond agitation-sedation scale (score -4). * hemodynamically stable. exclusion criteria: * rapidly developing neuromuscular disease * evolution of brain death * cardiopulmonary arrest * elevated intracranial pressure * ruptured/leaking aortic aneurysm * acute mi before peak troponin has been reached * absent lower limb * pregnancy * unstable fractures contributing to likely immobility * hospitalization prior to icu admission \>5 days * enrollment in another clinical trial
the effect of ketamine on postoperative cognitive dysfunction.

Conditions: Postoperative Cognitive Dysfunction

Summary: available evidence suggests that there is no significant difference in the incidence of postoperative cognitive dysfunction pocd when general anaesthesia and regional anaesthesia are compared\[13, 14\]. to the knowledge of the investigators , no studies are examining the effects of ketamine on cognitive outcomes in the setting of spinal anesthesia. thus, the purpose of this study was to compare the cognitive status, as assessed by the spmsq, of elderly patients undergoing orthopaedic surgery under spinal anaesthesia before and after ketamine administration. the authors hypothesized that patients receiving ketamine would exhibit better cognitive performance.


Eligibility criteria:
inclusion criteria: * patients scheduled for orthopaedic surgery under spinal anaesthesia. * asa physical status i to ii. exclusion criteria: * patients with a history of psychosis, schizophrenia, nephropathy, uncontrolled blood pressure, uncontrolled hepatic disorders, or allergy to ketamine. * patients with moderate to severe depression according to yesavage abbreviated geriatric depression scale, * patients presented with postoperative delirium or required medications other than study drugs. * ketamine administration is contraindicated.
prevalence of pd-l1 expression in patients with advanced urothelial carcinoma

Conditions: Urothelial Carcinoma

Summary: the purpose of this study is to assess the prevalence of pre-treatment tumor tissue pd-l1 expression in patients diagnosed with advanced urothelial carcinoma.

advanced urothelial carcinoma (uc) (locally advanced/unresectable or metastatic uc) is a fatal disease with 5-year survival rate of 5%. the most frequently studied diagnostic for advanced uc is the programmed death-ligand 1 (pd-l1) protein expression in tumor tissue. a better understanding of pd-l1 expression in a "real world" setting could help understand its clinical utility in the management and decision making in advanced uc and clinical trial design

Eligibility criteria:
inclusion criteria: * provision of written informed consent * age ≥18 years old * patient must have advanced uc confirmed by their hcp; histologically- confirmed diagnosis of uc an dhcp-confirmed advanced uc. * patient must be either currently receiving 1l systemic treatment for their advanced uc or will be starting 1l systemic treatment (i.e. "newly diagnosed" advanced uc; 1l therapy is defined as the first systemic therapy given for advanced uc). * patient remains eligible for the study if they received neoadjuvant or adjuvant platinum-based chemotherapy if their recurrence was more than 12 months after their last chemotherapy dose. * radio-sensitizing chemotherapy as part of chemoradiation is not counted as neoadjuvant or adjuvant chemotherapy; thus, the 12-month interval mention above does not apply, and the patient would be eligible * patients with available tumor tissue sample (fresh or archival - up to 3 years old) that was collected as part of soc any time prior to 1l treatment for advanced uc with a target of 18 slides (7 minimum) available for biomarker testing (pd-l1 and ttmb). already prepared slides must have been cut within 6 months prior to pd-l1 testing. exclusion criteria: * patients concurrently enrolled in other clinical trials that prohibit their participation in a non-interventional study * patient has resectable localized uc and has refused surgery * patients with history of non-urothelial active malignancy that completed therapy within 2 years from study enrollment except: * any resected in situ carcinoma or non-melanoma skin cancer * localized (early stage) cancer treated with curative intent (without evidence of recurrence and intent for further therapy) and in which no systemic therapy was indicated

Keywords: urothelial carcinoma registry
5-years pmcf study of ceramic dental implants one-piece versus two-piece.

Conditions: Edentulism; Tooth Loss

Summary: the goal of this cohort observational study is to compare in the survival rate of ceramic dental implants placed in patients with missing or hopeless teeth . the main question\[s\] it aims to answer are: * are there any significant differences in survival rate between the use of one-piece ceramic implant versus the two-piece (tl) variant? * what are the complications associated to the procedure and differences between the two groups.

the present clinical study protocol has the objective to compare the performance of different ceraroot ceramic implant models (16,11,21,12,14,34,34l) and the different sub-variants (one-piece versus two-piece). the geographic population of study will be the patients in two different dental centers located in barcelona (spain) and boulder (colorado, usa). the intended population as described in the device instruction for use (3) is " intended population: all fully-grown patients (men or women) requiring dental reconstruction using dental implants and who have no contraindications. the ceraroot® dental implants are specially indicated in patients with metal allergies and chronic illness due to metal allergies.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of partial or total edentulism. * specially indicated for patients with metal allergies and chronic illness due to metal allergies. exclusion criteria: 1. general contraindications: 1. local and systemic contraindications for surgery. 2. poor oral hygiene 3. patients with health problems, disease or any physical or psychological condition to which an oral surgery may be contraindicated. 2. relative contraindications: 1. previously irradiated bone 2. diabetes 3. anticoagulant medication 4. hemodynamic problems 5. bruxism 6. para functional habits 7. bad bone anatomy 8. smokers 9. none controlled periodontitis 10. malocclusions 11. tmj problems 12. diseases in the oral cavity 13. pregnancy 14. insufficient oral hygiene for adequate health. 3. local contraindications 1. insufficient bone quantity or quality 2. remaining of roots 3. localized periodontal disease 4. any pathology in the neighboring teeth.

Keywords: dental implant ceramic dental implant zirconia implant y-tzp metal-free
microsurgical resection of intramedullary spinal cord metastases

Conditions: Spinal Cord Metastasis; Spinal Cord Tumor Malignant Intramedullary; Functional Outcome; Radiotherapy; Complications; Spinal Cord Neoplasms

Summary: the aim of the study is to establish a multi-center, retrospective database for patients with intramedullary spinal cord metastases (iscm) and analyse the functional outcome in surgically treated iscm patients. the hypothesis is that the surgical treatment of selected iscm patients does not lead to persistent morbidity and does not increase mortality, compared to patients that are treated non-operatively. secondary objectives are to assess pre- to postoperative neurological deficits, ambulatory status, and overall survival of surgically treated iscm patients. the investigators intend to include a control cohort of patients with iscm from participating centers, who underwent non-surgical oncological treatment (radiotherapy with or without chemotherapy). this control cohort of patients will be used to match patients with and without surgical treatment. primary endpoint (analysed in surgically treated iscm patients): functional outcome at 90 days after treatment initiation, measured by the modified mccormick scale. this is a score for grading of neurological function in spinal cord conditions. the mccormick scale ranges from grade i (neurologically intact) to grade v (paraplegic or quadriplegic). the mccormick scale is suitable for our retrospective study because of its good reproducibility and comparability. secondary endpoints (analysed in surgically treated iscm patients and analysed in matched patients with and without surgical treatment): * functional outcome by the mccormick scale and the modified japanese orthopaedic association scale (mjoa) at 6 and 12 months. this is a score evaluating motor function of upper and lower extremities, sensory function of upper extremities and sphincter function / voidance. the mjoa ranges from 0 - 18 points, with higher score values representing better functional outcome. the minimum clinically important difference of the mjoa is 1-2 points, and scores lower than 14 indicate moderate myelopathy, scores lower than 11 indicate severe myelopathy. * ambulatory status and continence at 90 days, 6 \& 12 months (determined by mjoa subscores) * neurological outcome, measured by american spinal cord injury association (asia) * impairment scale at 90 days, 6 and 12 months * rate \& type of complications at 90 days after treatment according to the novel therapy * disability-neurology grade (tdn grade)16 * overall survival (in days)


Eligibility criteria:
inclusion criteria: * adult patients admitted to one of the participating centres and treated for iscm * available documentation of admission and postoperative status exclusion criteria: - patients under the age of 18

Keywords: spinal cord metastasis
ntx-001 to repair peripheral nerve transection(s)

Conditions: Peripheral Nerve Transections, Acute or Planned in Upper Extremity and Facial Nerves

Summary: the proposed use of ntx-001 for transections of upper extremity and facial peripheral nerves, acutely or planned.

for this expanded access program, there is a case-by-case internal review process conducted by neuraptive after the respective investigator provides a prospective case narrative for enrollment consideration. allowed sunderland classifications are iv degree (seddon's class ii) and v degree (seddon's class iii). if the case is approved, the investigator can move forward. patients who are between twelve (12) and eighty (80) years of age and has clinical evidence of a peripheral nerve transection from conditions or interventions that has or may result in motor and/or sensory impairment and require surgical treatment. all peripheral nerve repairs including gap repairs (autografts) will be considered for enrollment.

Eligibility criteria:
inclusion: 1. the patient has clinical evidence of a peripheral nerve transection from conditions or interventions that has or may result in motor and/or sensory impairment and requires surgical treatment. exclusion: 1. patients whose nerve repair will occur greater than 48 hours after nerve transection. 2. patients requiring repair of the intracranial portion of any nerve. 3. patients requiring a nerve repair involving an allograft or conduit. 4. patients expected to show signs of spontaneous recovery by 12 months (e.g., bell's palsy). 5. patients who, in the judgement of the investigator, are not likely to demonstrate meaningful recovery within a reasonable time frame during follow-up due to significant muscle atrophy or other morbidity. 6. the patient has documented history or clinical signs of any condition where ntx-001 might not prove beneficial (e.g., systemic neuromuscular disease, systemic neurological deficit, or other treatments known to affect the growth and/or physiology of the neural and vascular system). 7. the patient has a known allergy to polyethylene glycol (peg) or human grade silicone.
epidural catheter thread between two different vendors

Conditions: Labor Pain

Summary: the aim of the study is to assess if there is a difference in ability to thread the epidural catheter from two different epidural pain management kits vendors

the aim of the study is to assess if there is a difference in ability to thread the epidural catheter from two different pain management kits. in order to improve patient care, if there is a difference in the time to thread epidurals with one kit over the other, we would like to use the kit with decreased time to thread in the future.

Eligibility criteria:
inclusion criteria: women in labor - exclusion criteria: * none
effects of urban nature on stress and quality of life

Conditions: Stress, Psychological

Summary: the aim of this study is to investigate the effects of regular nature therapy in urban nature with guidance of a licensed nature therapist on stress, quality of life and physical symptoms of subjects with elevated stress levels.


Eligibility criteria:
inclusion criteria: * stress with at least 4 of 10 points on the numeric analogue scale (nas) at least 1 month * at least 3 of the following 8 stress-associated symptoms: sleep disturbances, inappetence or increased appetite, shoulder neck tension/back pain, tension headache, concentration disturbances, exhaustion, nervousness/irritability, stress-associated digestive complaints. exclusion criteria: * serious acute or chronic diseases * pregnancy or lactation * known serious mental illness * immobility or restriction for gymnastics exercises due to orthopaedic, neurological or other medical cause * participation in another study

Keywords: nature therapy stress
development of escitalopram genomic device by using candidate gene approach and genome-wide scanning

Conditions: Depression; Continuous Antidepressant Abuse; Adverse Reaction to Drug

Summary: to reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning).

the purposes of this study are: 1. to reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning) 2. to improve the success rate of escitalopram treatment response for depressed patients

Eligibility criteria:
inclusion criteria: 1. eligible patients were enrolled in the clinical trials program of hte samsung medical center geropsychiatry and affective disorder clinics(seoul, korea). they received a semistructured diagnostic interview, the samsung psychiatric evaluation schedule. the affective disorder section of the samsung psychiatric evaluation schedule uses the korean version of the structured clinical interview for the diagnostic and statistical manual of mental disorders, fourth edition. 2. interview with one more patient's family member for objective diagnosis and final diagnosis decision by agreements of two more psychiatric physicians exclusion criteria: 1. received psychotropic medication within 2 weeks of the study or fluoxetine within 4 weeks 2. potential study participants for pregnancy, significant medical conditions, abnormal laboratory baseline values, unstable psychiatric features(eg.suicidal), history of alcohol of drug dependence, seizures, head trauma with loss of consciousness, neurological illness, or concomitant axis i psychiatric disorder.

Keywords: genomic devices prediction of escitalopram response depressed patients
circadian rhythms in patients with ibd or celiac disease upon diagnosis and medical follow-up

Conditions: Inflammatory Bowel Diseases; Circadian Dysregulation

Summary: patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed ibd patients/ celiac disease and healthy controls. upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history. blood samples will be drawn for crp and clock gene expression in systemic wbc. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with ibd.


Eligibility criteria:
inclusion criteria: * ibd or celiac patients with a confirmed diagnosis, recruited upon diagnosis. * both male and female * age 6-25 years * medically treated for ibd in our institute. exclusion criteria: * genetic disorder. * known primary or secondary immunodeficiency . * pregnancy or lactating