Kornimate/medical-research-clean huggingface dataset:
effects of liraglutide on the cognitive function in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: type 2 diabetes mellitus (t2dm) can impaire cognitive function,the prevalence of alzheimer's disease(ad) in t2dm patients is 1.5 to 2.5 times higher than the general population.cognitive impairment seriously affects the health and quality of life of the elderly. prevention and treatment measures for cognitive decline in persons with t2dm has not been well studied. glucagon-like peptide-1 (glp-1) is a member of an endogenous class of incretin hormones synthesized in intestinal epithelial l-cells.glp-1 enhances glucose-dependent secretion of insulin,inhibits glucagon secretion, slows gastric emptying and reduces food intake. liraglutide is a glucagon-like peptide type 1 (glp-1) analogue. it has been proved that liraglutide can improve insulin resistance and cognitive function in ad animals. therefore, it is speculated that liraglutide may interfere with the occurrence and development of cognitive dysfunction in patients with t2dm. in order to confirm the effects, the investigators conduct an open, prospective, positive controlled study in patients with t2dm. the effect on bmi,waist circumference, hip circumference, waist-to-hip ratio,fasting plasma glucose，glycosylated hemoglobin,blood lipids and cognitive function were measured to explore the effects of liraglutide in patients with t2dm. the overall goal of this study is to explore the effects of liraglutide on the cognitive function in patients with type 2 diabetes mellitus and make further contribution to the improvement of cognitive function.


Eligibility criteria:
inclusion criteria: * type 2 diabetes。 exclusion criteria: * type 2 diabetes with acute diabetic complications. * type 1 diabetes. * other diseases affecting cognitive function (congenital dementia,brain trauma,severe heart dysfunction,severe kidney dysfunction,severe lung dysfunction,epilepsy,severe hypoglycemic coma,cerebrovascular disease,ischemic heart disease,etc). * alcohol abuse,mental illness and psychoactive substance abuse. * history of thyroid disease. * any surgical or medical conditions that significantly influence absorption, distribution, metabolism or excretion of the intervention drugs.

Keywords: type 2 diabetes mellitus cognitive function liraglutide
sensitivity of the home macular perimeter (hmp)

Conditions: Age Related Macular Degeneration; Choroidal Neovascularization

Summary: estimate the sensitivity of the hmp test in identifying visual field functional defects in subjects with cnv secondary to amd

the hmp device is intended to aid patients in identifying their visual abnormalities and in addition to their own symptoms or amsler grid use and aid in their prompt referral to eye care professional examination so clinical diagnosis can be made. as such the goal of the clinical plan is to demonstrate that patients who have cnv do demonstrate visual field abnormalities when tested with the hmp

Eligibility criteria:
inclusion criteria: * capable and willing to sign a consent form and participate in the study * subjects with amd related lesions: new onset (up to 60 days) non-treated cnv * age \>50 years * va with habitual correction \>20/200 in study eye * familiar with computer usage exclusion criteria: * evidence of macular disease other than amd or glaucoma in the study eye * presence of any significant media opacity that precludes a clear view of the macular area as identified in the study eye by biomicroscopy, cfp, or fa * any non-macular related ocular surgery performed within 3 months prior to study entry in the targeted eye * inability to tolerate intravenous fa * participation in another study with the exclusion of areds study

Keywords: hmp, cnv, php, hphp, amd
the novel electrolyzed water spray treatment mild senile groin eczema, neurodermatitis and psoriasis

Conditions: Groin Infection; Neurodermatitis; Psoriasis; Eczema

Summary: the purpose of this study is to test whether spraying the itching of inflammation skin and groin patients by use of the novel electrolyzed water spray will produce improvement in the condition of itching.

in this study, water inculding tap water,pure water and salt water, and an apparatus for producing electrolyzed water (https://www.deposon.com.cn; https://www.deposon.com）were used to generate an electrolyzed water mist spray or spray. this instantly generated electrolyzed water mist spray or spray has oxidation-reduction potential (orp) ≥1200mv,and contains non-specific total oxidation capacity which equals to 0.28±0.10ppm,0.06±0.04ppm and 3.92±0.39ppm of desolved ozone. this instantly generated electrolyzed water mist spray or spray does not release detectable ≥0.1mg/m3 of gaseous ozone. this instantly generated electrolyzed water mist spray or spray has ph 8.4±0.4 and releases negative air ion.the apparatus for producing electrolyzed water has a positive electrode which is covered by a conductive diamond material (patent# cn215308550u). this is an open-label, single-arm, and before and after treatment comparison study. this study uses this novel electrolyzed water device and the water spray to treat mild senile groin eczema, neurodermatitis and psoriasis.

Eligibility criteria:
inclusion criteria: * mild senile groin eczema, neurodermatitis and psoriasis. exclusion criteria: * severe senile groin eczema, neurodermatitis and psoriasis. * people with cognitive disorders. * 80 years or older.

Keywords: electrolyzed water device hydroxyl radical tap water spray itching
cataract surgery: femto ldv z8 versus conventional

Conditions: Cataract

Summary: the aim of the study is to demonstrate the performance and safety of the femtosecond laser-assisted anterior capsulotomy and lens fragmentation on human eyes using the femto ldv z8 compared to conventional technique in cataract surgery.

cataract surgery according to conventional procedure, with the exception of two steps (capsulotomy and lens fragmentation) which are performed with a femtosecond laser in the study group. used equipment for measurements is the same for both groups and in line with the normal equipment used for the conventional cataract treatment (group a) cataract surgery will be performed conventionally, this means the capsulorhexis will be performed manually by a hook, and the lens extraction will be done by phacoemulsification. (group b)

Eligibility criteria:
inclusion criteria: * eligible to undergo cataract extraction by phacoemulsification with primary intraocular lens implantation * able to co-operate with the docking system for the femtosecond laser * clear corneal media * 50 years of age or older * willing and able to return for scheduled follow-up examinations exclusion criteria: * minimal and maximal k-values of the central 3mm zone that differ by more than 5d on a keratometric map of the cornea * maximum k-value that exceeds 58d * minimal k-value of less than 37d * corneal disease or pathology, such as corneal scaring or opacity, that precludes transmission of laser wavelength or that distorts laser light * poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally * manifest glaucoma+oht (ocular hypertension), pseudoexfoliation * previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye * known sensitivity to planned concomitant medications * history of lens or zonular instability * keratoconus or keratectasia * immune compromised or diagnosis of connective tissue disease, clinically sign. atopic disease, insulin dependent diabetes mellitus, autoimmune diseases, ocular herpes zoster or simplex, endocrine diseases, lupus, ra, collagenosis and other acute or chronic illnesses that increases the risk to the subject or confounds the outcomes of this study, in the opinion of the study pi. * anterior chamber depth (acd) \ 4.8 mm as measured from the corneal endothelium. * extensive corneal scarring * developmental disability or cognitive impairment (would preclude adequate comprehension of the informed consent (ic) form and/or the ability to record the study measurements) * concurrent participation in another ophthalmological clinical study
neuropsychological outcome after cardiac arrest

Conditions: Heart Arrest, Out-Of-Hospital; Hypoxia-Ischemia, Brain; Cognition Disorders; Psychological Distress; Fatigue; Insomnia

Summary: this study is a sub-study to the large pragmatic target temperature management 2 trial (ttm2-trial, clinicaltrials.gov identifier: nct02908308), assessing effectiveness of controlled hypothermia after out-of-hospital cardiac arrest (ohca). this study is designed to provide detailed information on cognition after ohca and its relationship to associated factors as emotional function, fatigue, and sleep. a secondary aim is to utilize this information to validate a neurocognitive screening battery used 6 months after ohca in the ttm2-trial. approximately 7 and 24 months after ohca, survivors at selected ttm2 study sites will perform a standardized neuropsychological assessment including performance-based tests of cognition and questionnaires of behavioral and emotional function, fatigue, and insomnia. at 1:1 ratio, a control group of myocardial infarction (mi) patients but no occurrence of cardiac arrest will be recruited and perform the same test battery. group differences at 7 and 24 months will be analyzed per cognitive domain (verbal, visual/constructive, short-term working memory, episodic memory, processing speed, executive functions). results of the ohca survivors on the ttm2 neurocognitive screening battery will be compared with neuropsychological test results at 7 months time.


Eligibility criteria:
inclusion criteria: * ohca of a presumed cardiac or unknown cause (ohca cohort only) * sustained return of spontaneous circulation (rosc) during intensive care - defined as 20 minutes with signs of circulation without the need for chest compressions (ohca cohort only) * unconsciousness - defined as not being able to obey verbal commands (four-score motor response of \<4) and no verbal response to pain after sustained rosc (ohca cohort only) * inclusion within 180 minutes of rosc (ohca cohort only) * during intensive care - eligible for intensive care without restrictions or limitations (ohca cohort only) * mi with performed coronary angiography (mi cohort only) exclusion criteria: * temperature on admission \<30°c (ohca cohort only) * on extracorporeal membrane oxygenation (ecmo) prior to return of spontaneous circulation (ohca cohort only) * obvious or suspected pregnancy * intracranial bleeding (ohca cohort only) * severe chronic obstructive pulmonary disorder (copd) with long-term home oxygen therapy * clinical dementia diagnosis before the event * inability to speak the local language well enough to complete the assessment without assistance from an interpreter * inability to meet for a face-to-face examination * clinical frailty scale index ≥8, indicating very severe frailty * cardiac arrest before or in connection with mi (mi cohort only) * active substance abuse

Keywords: neuropsychology
a study of the efficacy and safety of ertugliflozin monotherapy in the treatment of participants with type 2 diabetes mellitus and inadequate glycemic control despite diet and exercise (mk-8835-003, vertis mono)

Conditions: Type 2 Diabetes Mellitus

Summary: this trial will evaluate the efficacy and safety of ertugliflozin monotherapy in the treatment of participants with type 2 diabetes mellitus (t2dm) and inadequate glycemic control on diet and exercise. this trial consists of a run-in period of 3 to 11 weeks, a 26-week placebo-controlled treatment period (phase a), and a 26-week active treatment period (phase b). the primary hypotheses of the trial are that at week 26, the mean reduction from baseline in hemoglobin a1c (a1c) for 15 mg ertugliflozin is greater than that for placebo and the mean reduction from baseline in a1c for 5 mg ertugliflozin is greater than that for placebo.


Eligibility criteria:
inclusion criteria: * diagnosis of t2dm in accordance to american diabetes association guidelines * participants with no prior allowable oral anti-hyperglycemic agents (aha) for at least 8 weeks prior to study participation or participants on a single allowable oral aha at the start of study participation * participants on a single allowable aha must be willing to discontinue this medication at the screening visit (s2) and remain off this medication for the duration of the trial. allowable oral ahas for discontinuation are metformin, sulfonylureas, dipeptidyl peptidase-4 (dpp-4) inhibitors, glinides or alpha-glucosidase inhibitors. exclusion criteria: * history of myocardial infarction, unstable angina, arterial revascularization, stroke, transient ischemic attack, or new york heart association (nyha) functional class iii-iv heart failure within 3 months of study participation * a clinically significant electrocardiogram abnormality * a history of malignancy ≤5 years prior to study participation, except for adequately treated basal or squamous cell skin cancer or in situ cervical cancer * a known hypersensitivity or intolerance to any sodium-glucose co-transporter 2 (sglt2) inhibitor or metformin * on a blood pressure or lipid altering medication that have not been on a stable dose for at least 4 weeks prior to study participation * a surgical procedure within 4 weeks prior to study participation or planned major surgery during the trial * donation of blood or blood products within 6 weeks of study participation or plans to donate blood or blood products at any time during the trial * pregnant or breast-feeding, or is expecting to conceive during the trial, including 14 days following the last dose of study drug
evaluation of the accuracy and usability of the acr | u.s. urine analysis test system in the lay user hands

Conditions: Albuminuria

Summary: eligible subjects meeting the pathological profile will be recruited at the designated site by the study personnel. following subject consent, the subjects will be evaluated for eligibility based on their health condition and history. the acr \| u.s. kit, in its original packaging, along with the acr \| u.s. smartphone application will be provided to the subject in a simulated home- use environment. all subjects will be provided with a list of tasks to complete, including providing a urine sample and operating the acr \| u.s. device on 2 mobile phones. after completing the test, the lay user will complete a post-test questionnaire. the study observer will also complete a questionnaire to collect information regarding the lay users' use of the acr \| u.s. the device use will be compared with identified risks to determine if the percentage of failures is acceptable. additionally, measurable usability criteria for specific, critical steps will be evaluated. following the usability test performed by the lay user, the subjects' urine samples will be tested by the study staff using the comparator device. these results will be considered as the "true value".


Eligibility criteria:
inclusion criteria: * males and females 18-80 years of age. * subjects diagnosed with a disease that normally represents itself with an abnormal concentration of albumin: * diabetes type i/type ii, * hypertension, * any kidney disease, * other relevant conditions, * or, subjects who are healthy or pregnant. * subject is familiar with the use of a smartphone. * subject is capable of comprehending and following instructions in english. * subject has facility with both hands. * subject is capable and willing to adhere to the study procedures. * subject is capable and willing to provide informed consent. exclusion criteria: * subject has dementia. * subject has severe mental disorders. * subject cannot collect urine in a receptacle. * subject is visually impaired (cannot read the user manual). * any additional reason the study physician believes disqualifies the subject from participating in the study.
medication regimen complexity and glycemic control in patients with diabetes

Conditions: Diabetes Mellitus

Summary: polypharmacy is an alarming health issue that is defined as prescription of multiple medications, of which some are redundant or unnecessary. due to comorbidities, diabetic patients are often prescribed multiple medications. over prescribing occurs either due to, prescribing medications that are not indicated, continuation of certain medications beyond the time of indication, or prescribing more than one medication with the same effect. improving glycaemic control is the cornerstone for the prevention and treatment of the diabetic complications.

hypothesis in addition to the side effects and cost of the unnecessary medications, the investigators hypothesis is that poly-pharmacy will adversely affect patients' compliance with the necessary medications.the investigators propose that elimination of unnecessary medications might improve patients' compliance and consequently improve glycemic control diabetic patients.

Eligibility criteria:
inclusion criteria: all diabetic patients who are eligible by fulfilling all of the following criteria: 1. hgba1c ≥7 mg/dl. 2. 2) poly-pharmacy: defined as the use of five or more medications. 3. non- compliance: patients were surveyed with both direct and indirect methods to identify non adherence. exclusion criteria: exclusion after recruitment any patient whose diabetic medications regimen changed after recruitment due to hospitalisation, illness, stress or patients preference, will be excluded.
enhanced outcome prediction in cutaneous squamous cell carcinoma using deep-learning and computational histopathology

Conditions: Squamous Cell Carcinoma of the Skin

Summary: evaluate a deep-learning model trained on computational histopathology for predicting outcomes in cutaneous squamous cell carcinoma


Eligibility criteria:
histologically-confirmed diagnosis of primary cutaneous squamous cell carcinoma
clinical and instrumental evaluation of swallowing in children with cerebral palsy

Conditions: Cerebral Palsy; Deglutition Disorders

Summary: the purpose of this study is to correlate the alimentary consistencies and deglutition disorders in children with cerebral palsy.

cross-sectional and quantitative study with sample consisted of 50 children with cerebral palsy. the data collection consisted in detection of the main dysphagic manifestations in different consistency of food and types of cerebral palsy.

Eligibility criteria:
inclusion criteria: * children with cerebral palsy diagnoses were involved, independent from the pre, peri and postnatal factors and from the type of cerebral palsy exclusion criteria: * children who presented oropharyngelarynx structural abnormality and/or impossibility to feed by oral way

Keywords: cerebral palsy deglutition deglutition disorders endoscopy
bipolar versus monopolar resection of benign prostate hyperplasia

Conditions: Acute Hyponatremia

Summary: aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and transurethral resection of prostate (turp) syndrome undergoing turp. fifty-three patients scheduled for elective turp were enrolled in this prospective clinical study. patients were included one of two groups (group monopolar and group bipolar).

background and purpose: aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and transurethral resection of prostate (turp) syndrome undergoing turp. methods: fifty-three patients scheduled for elective turp were enrolled in this prospective clinical study. patients were divided into two groups. patients in group m (monopolar) (n=25) were used monopolar resectoscope (karl storz, tottling, germany) and 5% mannitol as irrigating solution. patients in group b (bipolar) (n=25) were used bipolar resectoscope turis (olympus, tokyo, japan) and isotonic saline as irrigating solution. patients who received spinal anaesthesia were given 2.5-3 ml 0.5% hyperbaric bupivacain intrathecally and others were given general anaesthesia. patients demographics, prostate volumes, hemodynamic parameters, volumes of irrigation and iv solutions were recorded. blood samples were collected preoperatively (control), 45 minutes after the induction (2nd measurement) and 1 hour after the end of the operation for analyzing serum electrolytes, osmolarity, hemoglobin values.

Eligibility criteria:
inclusion criteria: * men were older than 50 years * men suffered from symptomatic benign prostatic hyperplasia. exclusion criteria: * history of severe heart failure * history of respiratory failure * history of bleeding diathesis

Keywords: monopolar bipolar turp syndrome hyponatremia
opioid-sparing versus sevoflurane anesthesia on early postoperative hypoventilation in laparoscopic bariatric surgery

Conditions: Anesthesia; Hypoventilation; Opioid Use; Bariatric Surgery

Summary: determine the incidence of early post-operative hypoventilation in post-anesthesia care unit (pacu) in patients undergoing laparoscopic bariatric surgery under opioid-sparing compared with sevoflurane-based anesthesia.

the incidence of early postoperative hypoxemia in the literature is diverse, this may be due to multivariable, including patient-related factors, anesthesia-related factors, and surgery-related factors. because of the controverse regarding the incidence of postoperative hypoxemia and the evidence of anesthetic technique of choice, interest in prevention and early management of early postoperative hypoxemia after laparoscopic bariatric surgery is continued.

Eligibility criteria:
inclusion criteria: * all adult patients ≥ 18 years * admitted to the post anesthesia care unit after bariatric surgery exclusion criteria: • preoperative hypoxemia which is determined by a peripheral capillary oxygen saturation (spo2) reading of \< 90% on room air
pulse pressure variation for prediction of fluid responsiveness in coronary artery disease patients with diastolic dysfunction

Conditions: Fluid Responsiveness Predictability

Summary: the investigators hypothesized that predictability of pulse pressure variation (ppv) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.


Eligibility criteria:
inclusion criteria: * patients older than 20 years * scheduled for elective coronary artery bypass grafting * normal diastolic function (e/e' \ 15) according to preoperative echocardiographic evaluation exclusion criteria: * arrythmia, * reduced left ventricular function (ejection fraction \< 40%) * valvular heart disease requiring concomitant surgical correction * pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm hg) * peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection) * end-stage renal disease

Keywords: pulse pressure variation fluid responsiveness diastolic dysfunction