Kornimate/medical-research-clean huggingface dataset:
analysis of lymph node metastasis and tumor deposit in the short gastric mesentery following total gastrectomy for gastric cancer

Conditions: Gastric Cancers

Summary: this study aims to explore lymph node metastasis in the short gastric mesentery following total gastrectomy with d2 lymphadenectomy plus complete mesogastric excision, providing evidence-based medicine for standardizing lymph node dissection in gastric cancer.

according to the 6th edition of the japanese gastric cancer treatment guidelines; total gastrectomy with d2 lymphadenectomy includes groups no.1 to no.7, no.8a, no.9, no.11p, no.11d, and no.12a. the no.4sa group lymph nodes are defined as the lymph nodes along the short gastric vessel, no.10 group lymph nodes are defined as the lymph nodes at the splenic hilum including the lymph nodes at the roots of the short gastric arteries. in routine total gastrectomy with d2 combined with cme surgery, the standard practice involves resection of the short gastric mesentery (no.4sa group and no. 10 group). there are typically 3-4 short gastric arteries in the human body, further investigation is required to determine the lymph node metastasis rates in each short gastric mesentery. patients undergoing total gastrectomy with d2 combined with cme will have their short gastric mesenteries anatomically separated for examination, and this aims to analyze the positive rate of lymph nodes in the short gastric mesentery and investigate the correlation between tumor location, staging, and lymph node metastasis in the short gastric mesentery.

Eligibility criteria:
inclusion criteria: 1. aged older than 18 years and younger than 85 years 2. primary gastric adenocarcinoma confirmed by preoperative pathology result 3. ct2-4an0-3m0 at preoperative evaluation according to the american joint 8 committee on cancer (ajcc) cancer staging manual 8th edition 4. patients who received total gastrectomy with d2 lymphadenectomy plus complete mesogastric excision 5. american society of anesthesiologists (asa) class i, ii, or iii 6. written informed consent exclusion criteria: 1. negative preoperative biopsy 2. too late tumour stage or metastasis (ct4b/m1) 3. bmi\>30 kg/m2 4. previous neoadjuvant chemotherapy or radiotherapy 5. previous upper abdominal surgery 6. combined with other malignant diseases 7. reject operation

Keywords: gastric cancer lymph node dissection short gastric mesentery lymph node metastasis tumor location
real-time continuous cardiac output measurements

Conditions: Cardiac Output, Low

Summary: study to assess the feasibility of real-time automatic cardiac output measurements using transthoracic echocardiography (tte)

rationale: study to assess the feasibility of real-time automatic cardiac output measurements using transthoracic echocardiography (tte) objective: to assess the correlation and feasibility of real-time automatic continuous cardiac output measurements using transthoracic ultrasound (tte) in adult icu-patients in comparison to flotrac measurements study design: prospective, feasibility study study population: adult intensive care patients ( \> 18 years) intervention (if applicable): consecutive adult patients on the icu in which the there is an indication for continuous cardiac output measurements. main study parameters/endpoints: * percentage of patients in which continuous cardiac output can be measured using tte * correlation between continuous tte and flotrac measurements

Eligibility criteria:
inclusion criteria: * adult intensive care patients ( \> 18 years) exclusion criteria: * pregnancy * atrial fibrillation or other irregular heart rhythm

Keywords: cardiac output tte
building resiliency in patients admitted to the neuroscience intensive care unit and their caregivers

Conditions: Acute Brain Injuries

Summary: the investigators will compare a dyadic intervention (recovering together) with an attention placebo educational control in dyads of patients with acute neurological illnesses and their caregivers at risk for chronic emotional distress. the primary aim of this study is to determine the feasibility, credibility, and satisfaction with recovering together. the second aim is to show proof of concept for sustained improvement in emotional distress, post traumatic stress (pts), resiliency and interpersonal communication outcomes in patients and caregivers.

the investigators aim to improve the care of patients (pts) admitted to the neuroscience intensive care unit (nicu) and their family caregivers (cgs) by conducting a pilot feasibility randomized controlled trial (rct; n=80 dyads; 60 completers) of the dyadic resiliency program ("recovering together") to prevent chronic emotional distress in both pts and their cgs. eligible dyads include adult, english speaking pts with acute neurological injury (ani) admitted to the nicu, cleared medically and cognitively for participation by the nursing team, and their primary cgs. dyads who are randomly assigned to "recovering together" will receive 6 manualized sessions (2 in person at hospitalization and 4 through live video after discharge, to reduce burden and facilitate access to care) led by a clinical psychologist. dyads who are randomly assigned to the attention placebo educational control condition will receive 6 manualized sessions (2 in person and 4 through live video with a clinical psychologist), modeled after the recovering together program that will control for the dose of the intervention and support from therapist. dyads will complete assessment surveys before, after the intervention and 3 months later. clinical data on demographics, diagnosis, ani severity, and any medical complications will be extracted from electronic health records.

Eligibility criteria:
inclusion criteria: * male and female patients, 18 years or older * english fluency and literacy * access to high speed internet for video sessions * patient with an informal cg (family or friend who provides unpaid care) available and willing to participate * hospitalized with an acute brain injury within 1-2 days when first approached, or the primary caregiver of a patient currently admitted with an acute brain injury * either patient or caregiver within the dyads screens in for depression, anxiety, and/or ptsd exclusion criteria: * permanent or severe cognitive impairment severe enough to impede participation - this will be determined by nurses through an assessment conducted as part of usual care (mmse). * dyads where the patient is anticipated to die or to never be able to participate due to medical sequelae.

Keywords: psychiatry dyads patients caregivers psychosocial
effects of a time restricted eating protocol on resistance training men

Conditions: Fasting; Healthy

Summary: the study sought to investigate the effects of 16/8 time restricted eating (tre) with windows of 16 hours of fasting and 8 hours of eating on on body composition, muscle strength, and metabolic factors during resistance training in healthy resistance trained males

thirty-four resistance-trained males were randomly assigned to a tre group or to a control normal pattern group (nd) with a traditional meal pattern. the tre group consumed 100% of the daily energy needs in an 8-hour time window: from 1pm (post meridiem) to 8:00 pm whilst the nd group consumed 100% of their daily energy needs in 3 meals between 8:00 am (ante meridiem) and 8:00 pm. during the experimental period, training loads were similar and standardize in the two groups. partecipants were tested before and after 8 weeks of the intervention. body composition , basal metabolism, performances indexes and blood parameters were measured. after the completition of the first two months of study, subjects were ask to volunteer to continue the intervention for 10 extra months. a total of twenty subjects from, 10 from each group (tre or nd) continued and completed the second part of the study.

Eligibility criteria:
inclusion criteria: * continuously engaged in resistance training for at least 5 years * at least 3 years experience in split training routines * male exclusion criteria: * adherence to special diets * use of nutritional supplements (except a daily multivitamin-mineral and/or protein supplement) * use of steroids * use of medications

Keywords: fasting time restricted eating resistance training body composition inflammation
reveal 2 trial (evaluation of vgx-3100 and electroporation for the treatment of cervical hsil)

Conditions: Cervical Dysplasia; Cervical High Grade Squamous Intraepithelial Lesion; HSIL

Summary: hpv-303 is a prospective, randomized, double-blind, placebo-controlled study of vgx-3100 delivered intramuscularly (im) followed by electroporation (ep) delivered with cellectra™ 5psp in adult women with histologically confirmed high-grade squamous intraepithelial lesions (hsil) (cervical intraepithelial neoplasia grade 2 \[cin2\] or grade 3 \[cin3\]) of the cervix, associated with human papillomavirus (hpv-16) and/or hpv-18.


Eligibility criteria:
inclusion criteria: * women aged 18 years and above * confirmed cervical infection with hpv types 16 and/or 18 at screening * cervical tissue specimen/slides provided to study pathology adjudication committee for diagnosis scheduled to be collected within 10 weeks prior to anticipated date of first dose of study drug * confirmed histologic evidence of cervical hsil at screening * must be judged by investigator to be an appropriate candidate for the protocol-specified procedure required at week 36 * with respect to their reproductive capacity must be post-menopausal or surgically sterile or willing to use a contraceptive method with failure rate of less than 1% per year when used consistently and correctly from screening until week 36 * normal screening electrocardiogram (ecg) exclusion criteria: * microscopic or gross evidence of adenocarcinoma-in-situ (ais), high grade vulvar, vaginal, or anal intraepithelial neoplasia or invasive cancer in any histopathologic specimen at screening * cervical lesion(s) that cannot be fully visualized on colposcopy * history of endocervical curettage (ecc) which showed cervical hsil indeterminate, or insufficient for diagnosis * treatment for cervical hsil within 4 weeks prior to screening * pregnant, breastfeeding or considering becoming pregnant during the study * history of previous therapeutic hpv vaccination * immunosuppression as a result of underlying illness or treatment * receipt of any non-study, non-live vaccine within 2 weeks of day 0 * receipt of any non-study, live vaccine within 4 weeks of day 0 * current or history of clinically significant, medically unstable disease or condition which, in the judgment of the investigator, would jeopardize the safety of the participant, interfere with study assessments or endpoint evaluation, or otherwise impact the validity of the study results * presence of acute or chronic bleeding or clotting disorder that would contraindicate im injections, or use of blood thinners within 2 weeks of day 0 * participation in an interventional study with an investigational compound or device within 30 days of signing informed consent * less than two acceptable sites available for im injection

Keywords: cervical intraepithelial neoplasia (cin) cin 2 cin 3 human papillomavirus (hpv) hpv-16 hpv-18 high grade squamous intraepithelial lesion (hsil) papillomavirus
exercise, creatine and coenzyme q10 for childhood myositis

Conditions: Myositis, Juvenile

Summary: children with jdm are weak and get tired because their muscles aren't able to work like healthy muscles. this can make it hard for them to do normal everyday things and can make them less happy about their lives compared to children without the disease. there are two nutritional supplements that help muscles use energy and recover after exercise: creatine and coenzyme q10. if the muscle has more energy, it may not be as weak and may not feel as tired or sore after exercise. because of this we want to see if having children with jdm take creatine and coenzyme q10 can make them stronger and less tired. if this works, we hope it will let them be able to do the things that healthy children can do, and make them feel better about their lives.


Eligibility criteria:
inclusion criteria: * ages 7 to 18 years * diagnosis of juvenile idiopathic inflammatory myopathy (jiim) according to the 2017 european league against rheumatism (eular)/american college of rheumatology (acr) criteria: ≥90% probability, age of onset \<18 years * subjects on a stable course of medication (unlikely to change over study treatment period as determined by treating physician) * minimum height of 132.5cm (required to fit on the cycle ergometer) exclusion criteria: * subjects with newly diagnosed jiim within the previous 6 months * subjects unable to cooperate with study procedures, or too weak to participate in the exercise testing * subjects with impaired kidney function as determined from pre-baseline visit screening lab values (egfr \<90 ml/min/1.73m\^2) * subjects currently taking anti-hypertensive drugs or blood thinners * subjects who are currently pregnant or planning to become pregnant within the study period
comparison of digital breast tomosynthesis to conventional mammography

Conditions: Breast Cancer

Summary: in march 2009, health canada approved tomosynthesis for use in screening and diagnosis of breast cancer. the tomosynthesis technology is designed as a complementary imaging model that is incorporated into the 2d mammography system. this new imaging system has the capability to provide 2d, 3d and combination mode models. it consists of generating thin slice images that can be viewed individually as multiple images from the same breast. tomosynthesis provides improved visibility of possible lesions within the breast. the study aims to compare the performance of tomosynthesis to the conventional digital mammography in detecting and characterizing suspicious findings in subjects who will be having breast biopsies.


Eligibility criteria:
inclusion criteria: * subject is female of any race and ethnicity * following routine mammography imaging, subject is categorized as breast imaging reporting and data system (bi-rads®) 4 or 5 because of calcifications / masses and architectural distortion will undergo study imaging within 30 days of routine imaging * subject will undergo 2d/3d digital breast tomosynthesis prior to biopsy exclusion criteria: * subject unable or unwilling to undergo informed consent * subjects who are unable or unwilling to tolerate compression * subjects who are pregnant or who think they may be pregnant * subjects who are breast-feeding * the subject is too large to be imaged on the large 24 x 30 cm detector
prospective assessment of the efficacy of hyaluronate knee injections in patients with osteoarthritis

Conditions: Knee Osteoarthritis

Summary: this study looks at the effect of an injectable medication called hyalgan on the cartilage of the knee in people who have osteoarthritis ("wear and tear arthritis") of the knee. hyalgan is a medication which is injected into the knee, and is fda approved to treat knee arthritis. we will be using magnetic resonance imaging (mri) and x-rays to look at knee cartilage to see how it responds over the course of a year to the injections. a comparison to patients taking oral pain medication will be made.


Eligibility criteria:
inclusion criteria: * age 45-90 * seeking medical care for painful knee osteoarthritis * alignment based on ap standing radiographs of neutral to 10º of valgus * no prior surgery on the ipsilateral knee * no history of major trauma to either knee or either hip * no history of congenital hip dysplasia * no history of inflammatory synovitis or crystalline arthropathy * no history of systemic rheumatic disease * cruciate and collateral ligament stability, defined by clinical examination * meniscus intact (mri grade ii degenerative signal acceptable) * noyes compartment score: no greater than 50% of cartilage thickness over an area greater than 15mm * if bilateral oa, the most painful knee, (as documented by vas scale for pain) which qualifies for the study will be entered. * if taking glucosamine chondroitin sulfate, discontinue at least one month prior to ha injections exclusion criteria: * previous ia ha injection in the ipsilateral knee * ia steroid in the ipsilateral knee in the past 3 months * mr evidence of inflammatory or hypertrophic synovitis * large joint effusion with a ballotable patella on baseline clinical exam * inability to safely perform mr imaging * active systemic infection * active malignancy (except non-melanomatous skin cancer) * allergies to ha or chicken products * clinical symptoms of an acute meniscal tear (locking, new acute mechanical symptoms etc...) * a recent injury to the knee * radiographic evidence of grade iii or iv kellgren and lawrence oa * chondrocalcinosis on radiographs * unwilling to discontinue or avoid glucosamine chondroitin sulfate for the 12 month study period * people taking blood thinners or who have bleeding problems * anticipated lower extremity surgery during the next 12 months * bmi \>30 kg/m2

Keywords: hyalgan knee osteoarthritis mri
pilot study of model based iterative reconstruction using 64-slice

Conditions: Posterior Fossa Hemorrhage; Lung Cancer; Flank Pain; Urolithiasis; Focal Hepatic Necrosis

Summary: this study is being performed to confirm that the new technique, model-based iterative reconstruction (mbir) with reduced radiation dose can deliver equivalent image quality for ct scans compared to current techniques (filtered back projection with adaptive statistical iterative reconstruction (fbp with asir) and also to demonstrate that mbir can improve general image quality characteristics at equivalent radiation dose levels.

see brief summary

Eligibility criteria:
inclusion criteria: * men or women 30 years of age or older voluntarily willing to sign an informed consent. * patients indicated for one of the following: cns: known or suspected pathology in the posterior fossa thorax: patients referred for staging of a known or suspected lung cancer abdomen: patients with acute flank pain and suspected urolithiasis or abdomen: patients with a known or suspected focal liver lesion exclusion criteria: * subjects less than 30 years of age * pregnant women as confirmed by urine test or current accepted institution standard * if iv contrast is required: * severe or uncontrolled allergy to iodinated contrast media * serum creatinine \> 1.7 mg/dl or estimated glomerular filtration rate \[egfr\] of \<60 mg/min as recorded in medical file or by current accepted institution standard * unable or unwilling to provide written informed consent by self or legal guardian at the time of study enrollment * unstable physical condition as identified by physician

Keywords: ct scan cns thorax abdomen staging of a known or suspected lung cancer suspected urolithiasis known or suspected focal liver lesion
the prevalence of sarcopenia in a cohort of haemodialysis patients and its correlation with mortality

Conditions: End-stage Kidney Disease; End-stage Renal Disease; Dialysis Dependent Chronic Kidney Disease; Sarcopenia

Summary: the study aims to explore the correlation between the prevalence of sarcopenia and one year mortality amongst patients on maintenance hemodialysis

in our study , we aim to explore the correlation between the prevalence of sarcopenia and one year mortality among patients on maintenance hemodialysis the lean muscle mass was measured using bio-impedance analysis (bia ). the hand-grip test was used to measure the function . sarcopenia was defined using european working group on sarcopenia in older people (ewgsop) definition which involves reduced muscle function and reduced muscle mass

Eligibility criteria:
inclusion criteria: * patients with end stage kidney disease on maintenance dialysis exclusion criteria: * unable to consent or terminal malignancy

Keywords: sarcopenia end stage renal disease end stage kidney disease dialysis dependent end stage renal disease
antibiotic prophylaxis before surgery versus after cord clamping in elective cesarean delivery - a double-blind, prospective, randomized placebo-controlled trial

Conditions: Elective Cesarean Section

Summary: in this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of administration, ie before skin incision or after umbilical cord clamping

background. perioperative antibiotic prophylaxis during elective cesarean section at term to reduce postoperative maternal infectious morbidity is generally used but may not be efficient based on the available data. also, the optimal timing of prophylactic antibiotic administration is unclear. methods. the investigators compared the effectiveness of cefazolin, administered before skin incision versus after umbilical cord clamping versus placebo in a three-arm randomized trial. the primary endpoint of the study was postoperative infectious morbidity, defined as wound infection, endometritis, or urinary tract infection. results: the primary outcome was observed in 18/370 women in group 1 (4.9%) and in 14/371 women in group 2 (3.8%), whereas it was noted in 45/371 women in group 3 (12.1%; p\<0.001 for group 1 vs. group 3; p\<0.001 for group 2 vs. group 3; p\<0.001 for group 1 vs. group 2 vs. group 3). the number needed to treat to avoid one primary outcome was 13. comparing groups 1 and 2, there was no statistically significant difference regarding the primary outcome (p=0.6). conclusions. in this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of administration, ie before skin incision or after umbilical cord clamping.

Eligibility criteria:
inclusion criteria: - elective cesarean section at term patientin \>18 years informed consent no known allergy to cefazolin no exposure to any antibiotic agent within 1 week prior to delivery exclusion criteria: - cesarean section before week 37 cephalosporin allergy age less than 18 years exposure to any antibiotic agent within 1 week prior to delivery

Keywords: elective cesarean section antibiotic prophylaxis cefazoline wound infection
turkish version of ottawa sitting scale in patients with stroke

Conditions: Fall Due to Loss of Equilibrium; Acute Stroke; Balance; Distorted; Fear

Summary: the aim of the study is to describe the cultural adaptation of the ottawa sitting scale and to examine the factor structure, reliability and validity of the scale in patients with stroke. the scale will be translated into turkish language by following the procedure. 80 patients will be recruited in the study. berg balance scale and trunk impairment scale will be included with turkish ottawa sitting scale to test the validity. outcome measures will be repeated by a second physiotherapist the day after the first assessment for interrater reliability and conducted twice within 2 weeks (test-retest) for reliability. the interrater and intrarater reliability of the ottawa sitting scale will be determined using intraclass correlation coefficients and internal consistency will be assessed using cronbach's alpha.


Eligibility criteria:
inclusion criteria: * diagnosed with acute stroke * aged above 18 years exclusion criteria: * patients who do not cooperate enough to read or approve the consent