Kornimate/medical-research-clean huggingface dataset:
the role of ultrasonography in predicting outcomes of fetal nephropathy

Conditions: Nephropathy

Summary: congenital anomalies of the kidneys and urinary tract are among the most frequently ultrasound-indentified malformations in the prenatal period. thanks to the introduction of fetal ultrasound in pregnancy screening programs, the diagnosis of these abnormalities in utero allows early manegement. in fact, prenatal diagnosis allows evolutionary control of the pathology and appropriate counseling, putting in place the best therapeutic strategies at birth. however, the predictive value of prenatal ultrasound findings is often difficult to establish. therefore, the investigators want to evaluate the postnatal outcomes in fetuses prenatally diagnosed with unilateral nephropathy, specifically the rate of live births, gestational age at delivery, neonatal weight, and the need for admission of the infant to the neonatal intensive care unit (nicu). the data collected will allow investigators to assess postnatal outcomes in fetuses prenatally diagnosed with unilateral nephropathy, identifying the prenatal ultrasound findings most associated with poor postnatal prognosis to define the role of ultrasonography in predicting outcomes of fetal nephropathy.

clinical data of single-pregnancy patients who were referred to the pregnancy at risk outpatient clinics of our center between 2007 and 2023 will be considered. these patients were evaluated with serial ultrasound checks at the outpatient clinics for the presence of suspected unilateral nephropathy that emerged during morphologic ultrasound performed between the 19th and 21st weeks of gestation. therefore, we will analyze the ultrasound data that emerged during serious outpatient checkups, the delivery data of patients who delivered at our center, and the postnatal data of newborns. information on the following will be collected for each patient: * age * type of suspected nephropathy (pyelectasis, hydronephrosis/hydroureteronephrosis, multicystic kidney, dysplasia) * gestational age at the time of suspected diagnosis * gestational age at the time of diagnosis * assessment of amniotic fluid * centile of affected kidney (\ 95°) * centile of unaffected kidney (\ 95°) * presence of associated abnormalities in the other anatomical districts * performance of invasive prenatal diagnostic methods (karyotype analysis and cgh-array) * progression of nephropathy * involvement of contralateral kidney * gestational age at the time of delivery * mode of delivery (vaginal/caesarean section) * sex of the newborn at birth * infant's weight at birth * ph of newborn at birth * apgar index at 5 and 10 minutes * possible admission to neonatal intensive care unit.

Eligibility criteria:
inclusion criteria: * single pregnancy * age greater than or equal to 18 years * detection of unilateral renal abnormalities during confidential ultrasound * delivery performed at the o.u. of obstetrics and prenatal age medicine * acquisition of informed consent form exclusion criteria: * request for voluntary termination of pregnancy

Keywords: fetal nephropathy
effectiveness of lifestyle counseling versus physical therapy on chronic low back pain

Conditions: Low Back Pain

Summary: background: low back pain is the leading cause of disability, affecting the quality of life and work productivity. it is the most common reason for seek medical help and advice. low back pain creates huge economical burden worldwide. to date, most ( 90%) of low back pain cases are not clinically defined with no preferred medical treatment 1. study objectives: to prove that consulting using the "stage of change" model for daily physical activity will lead to long term improvement of pain, disability and well-being parameters of those suffering from chronic low back pain, people age 25-55, when compared to conventional physical therapy. 2. study hypotheses: the intervention groups vs. physical therapy group will demonstrate that the following parameters will improve after: 3 months, one, two and five years. 1. pain reduction. 2. less disability - improvement in daily activities. 3. better feeling of health and well-being. 4. increased and better compliance to daily sport activities. 5. bmi reduction. 6. reduction of cigarette smoking. 7. reduction of usage of anti-analgesics and anti-inflammatory medications. 8. reduction in number of visits to physical therapy clinics due to low back pain. 3. methods: the present randomized intervention study that will include 220 healthy individuals, males and females aged 25-55 years old suffering from chronic or recurrent low back pain, with or without radiation to the legs that were referred to maccabi healthcare services physical therapy clinics in the sharon district in israel. these individuals will be randomized to one of the following two groups: 1. conventional physical therapy. 2. physical therapy focused on healthy lifestyle using the "stage of change" model. non-dependent observer will follow-up on the outcome parameters via phone calls and filling the questionnaire's with the relevant study participants following 3 months, 1 year, 2 and 5 years.


Eligibility criteria:
inclusion criteria: * men and women * age 25-55 years old * chronic / recurrent low back pain (over 3 months) * with or without radiation exclusion criteria: * rheumatoid disease * tumors * fibromyalgia * back surgery * road / work accidents * non hebrew speaking * pregnancy
upper limbs assessment in children with cerebral palsy

Conditions: Cerebral Palsy; Children

Summary: cerebral palsy is the leading cause of physical disability among children. manual dexterity and upper limbs functionality is limited between these children. the purpose of this study is to stablish a specific profile of school children with cerebral palsy based on the upper limbs assessment.

while the rates of perinatal and infant mortality have declined toward the end of the last century,the rate of cerebral palsy has remained at 2 to 2.5 per 1,000 live births. a high percentage of children with cerebral palsy have difficulty keeping up with the handwriting demands at school. the neurological impairments in children with cerebral palsy frequently limit the functionality of these children taken in to account the upper limbs variables. it should be interesting to describe a clinical profile based on this assessment.

Eligibility criteria:
inclusion criteria: * cerebral palsy diagnosis. * aged between 6 and 10 years old. * children attending a school. exclusion criteria: * severe cognitive impairment.

Keywords: functionality cerebral palsy handwriting
blood transfusion among patients with pelvic fracture in china

Conditions: Pelvic Fracture; Transfusion Reaction; Blood Transfusion Complication

Summary: according to the patient's blood management concept, this study intends to collect basic information, surgical data, blood transfusion related data and patient prognosis data of patients with pelvic fractures, and to construct a predictive model of intraoperative blood transfusion in patients with pelvic fractures by multiple linear regression analysis. to guide physicians use blood accurately during surgery. prompt doctors to reduce blood transfusion dose and improve patient prognosis by stopping bleeding and blood recovery before surgery.

2.1 research objectives: this study aims to construct a blood transfusion model for pelvic fractures, to guide the rational use of blood during surgery, and to improve the prognosis of patients. 2.2 research content: 2.2.1 collect basic data, surgical data, blood transfusion related data and patient prognosis related data of patients with pelvic fractures. 2.2.2 gradually incorporate and exclude data from multiple linear regression models. 2.2.3 verify the specificity and sensitivity of the intraoperative blood transfusion prediction model. 2.2.4 create a visualization window to guide clinical blood. 2.2.5 put into clinical trial and feedback, and continue to verify 2.3 key issues to be resolved 2.3.1 the factors related to intraoperative blood transfusion in patients with pelvic fractures (such as blood oxygenation, blood loss, hb value, intraoperative autologous blood recovery, blood pressure, heart rate, etc.) were initially screened by univariate analysis. 2.3.2 reasonably standardize the objective and subjective indicators of different units and different institutions. 2.4 expected research results intraoperative blood transfusion prediction model and window for patients with pelvic fractures. 2.5 assessment indicators published 1-2 papers. create a visual applet and put it into trial.

Eligibility criteria:
inclusion criteria: * (1) 1\<age\<80, and chinese residents living in china more than 3 years; * (2) hemoglobin value less than 100g/l during hospitalization; exclusion criteria: * (1) participants who suffered from pelvic fracture within 3 months * (2) participants who suffer from pathological fractures of the pelvis caused by malignant tumors * (3) participants with chronic anemia and coagulopathy * (4) participants who rufuse blood transfusion

Keywords: pelvic fracture predictive model blood transfusion perioperative period
evaluation of clinical and radiographic outcomes of surgical treatment for rotator cuff injury in patients over 70

Conditions: Cuff Rotator Syndrome

Summary: the aim of the study is to document the clinical-radiological results from the case series of patients surgically treated for rotator cuff lesions from 2009 to 2020 at the rizzoli orthopaedic institute shoulder-elbow department.

110 patients surgically treated for rotator cuff lesions from 2009 to 2020 will be included in a retrospective-prospective and interventional study with clinical and radiological evaluation at follow-up of at least 12 months.

Eligibility criteria:
inclusion criteria: 1. ≥70 years of age at the time of rotator cuff repair surgery 2. males and females 3. patients surgically treated for rotator cuff injury between 2009 and 2020 at the shoulder-elbow department of the rizzoli orthopaedic institute exclusion criteria: * all available patients will be invited to undergo clinical examination and radiological examination. in case some patients cannot undergo mri due to possible contraindications, they will still be seen to collect the primary clinical outcome

Keywords: cuff rotator retrospective study prospective study long-term clinical evaluation long-term radiological evaluation
oxaliplatin and s-1 (os) versus oxaliplatin and capecitabine (xelox) for advanced colorectal cancer

Conditions: Colorectal Neoplasm

Summary: the aim of this study is to compare the activity and safety of oxaliplatin and s-1 (os) and oxaliplatin and capecitabine (xelox) in patients with advance or recurrent colorectal cancer.

oxaliplatin and oral fluoropyrimidines (capecitabine or s-1) are active agents for colorectal cancer. recent a phase ii trial of combination chemotherapy of oxaliplatin with s-1 (os) and several phase ii trial of combination chemotherapy of oxaliplatin with capecitabine (xelox) demonstrated good activity and mild toxicity in advanced colorectal cancer. oxaliplatin and s-1 or capecitabine have distinct mechanisms of action and no overlap of key toxicities. furthermore, oxaliplatin and fluorouracil were shown to be highly synergistic, not only in preclinical models but also in subsequent clinical trials.

Eligibility criteria:
inclusion criteria: * histologically confirmed colorectal adenocarcinoma, initially diagnosed or recurred * unresectable, locally advanced or metastatic * at least one uni-dimensional measurable lesion by recist criteria * age 18 to 75 years old * estimated life expectancy ≥3 months * ecog performance status ≤2 * adequate bone marrow function (wbcs ≥ 4,000/µl or absolute neutrophil count ≥ 1,500/µl, platelets ≥ 100,000/µl) * adequate kidney function (creatinine \< 1.5 mg/dl) * adequate liver function (bilirubin \< 2.0 mg/dl, transaminase levels \<2.5 times the upper normal limit) * written informed consent exclusion criteria: * other tumor type than adenocarcinoma * previous history of chemotherapy (exception : neoadjuvant or adjuvant chemotherapy without oxaliplatin) * presence of cns metastasis, psychosis, or seizure * obvious bowel obstruction * evidence of serious gastrointestinal bleeding * past or concurrent history of neoplasm other than colorectal adenocarcinoma, except for curatively treated non-melanoma skin cancer or in situ carcinoma of the cervix uteri * pregnant or lactating women, women of childbearing potential not employing adequate contraception * other serious illness or medical conditions

Keywords: colorectal neoplasm s-1 capecitabine oxaliplatin
evaluating parenting styles and child temperament associated with child anxiety disorders

Conditions: Anxiety Disorders; Obsessive Compulsive Disorder

Summary: this study will look at similarities and differences in family processes and child temperament among children with and without symptoms of anxiety disorders.

anxiety disorders are among the most common childhood disorders. although anxiety is a normal part of life and growing up, for some children this anxiety becomes chronic, relentless, and progressively worse if left untreated. physical symptoms typically accompany the intense anxiety caused by the disorder, and may include blushing, profuse sweating, trembling, nausea, and difficulty talking. effective treatments for anxiety disorders are available, and research continues to yield new, improved therapies that can help most people with anxiety disorders to lead productive, fulfilling lives. this study will look at similarities and differences in family processes and child temperament among children with and without symptoms of anxiety disorders. results from this study may improve future treatment of children with anxiety disorders. families participating in this observational study will be mailed parent and child questionnaires that should be completed prior to the first study session. the child questionnaires will ask for information regarding the child's feelings and family interactions. parent questionnaires will ask for information about their own personal feelings as well as the child's feelings, symptoms, and behaviors. study participation will last 2 days. on the first day of the study, families will undergo a 3-hour diagnostic interview in which questions similar to those found on the questionnaires will be revisited. on the second day, mothers and their children will participate in three different observation tasks that explore how families interact and respond to certain situations. these tasks may include discussing certain anxiety-provoking situations, putting puzzles together, and creating an ending to a story. before each task, the child will be placed alone in a separate room where the child will be asked to relax. throughout the tasks, the child's heart rate and breathing will be recorded by a machine. the tasks will be videotaped but will be viewed only by research staff for data analysis purposes and to ensure that all safety procedures were followed. upon study completion, if it appears that a child has an anxiety disorder, parents of the child will be notified and will receive treatment referrals as needed.

Eligibility criteria:
inclusion criteria for children: * english-speaking exclusion criteria children: * mental retardation * current or past diagnosis of autistic spectrum disorders * current or past diagnosis of psychotic disorders

Keywords: children healthy controls assessment
effect of nursing interventions using roy adaptation model with virtual reality on social anxiety in youth

Conditions: Social Anxiety Disorder

Summary: the study was conducted to determine the effect of nursing practices based on the ram integrated with vr on the social anxiety level of young people.the main questions it aims to answer are: h1: "nursing practices based on the roy adaptation model integrated with virtual reality are effective in reducing the level of social anxiety in young people." h2: "nursing practices based on the roy adaptation model integrated with virtual reality are effective on the level of life satisfaction, independent of anxiety level and as a predictor of social anxiety" this single-blinded randomized controlled study utilized a pretest-posttest control group and single-blinded randomized control group, preintervention pretest, postintervention posttest, and follow-up test design. the study population consisted of students from a foreign language preparatory class at a university. in this context, the anxiety subdimension of the lscq was calculated for 785 preparatory class students aged 18-26. a total of 242 students scoring 30 and above on the anxiety subdimension of the lscq were reached. the research was completed with a sample of 72 students who met the inclusion criteria within this target group. individuals who do not participate in two or more of the six interviews will be excluded from the study. the study\&#39;s experimental design was organized according to the consort guidelines

the study used virtual environments and characters based on "the amelia vr platform" for mental health researchers developed by psious software company as a supportive tool in nursing interventions for social anxiety. the virtual environments included scenarios such as presentating in a large conference hall, conducting a business/office meeting with an authority figure and colleagues, presenting to a small group in a seminar hall, and socializing with friends. these environments comprehensively evaluate individuals' issues in public speaking and can also be used within the scope of a separate program to test and improve skills such as verbal communication and academic presentation. the whole process is controlled by a counselor via a computer connected to the platform. the counselor can manipulate the content, duration, and intensity of the process in a controlled manner for the purpose of the application.

Eligibility criteria:
inclusion criteria: * liebowitz social anxiety scale (lsas) anxiety subscale score of 30 and above, * having not used a psychiatric drug in the last three months, * not having received psychotherapy for social anxiety before, * willingness and volunteering to participate in the research. exclusion criteria: * active suicide risk, * psychotic symptoms, * individuals who do not participate in two or more of the six interviews will be excluded from the study.

Keywords: social anxiety; young people; roy adaptation model; virtual reality; psychiatric nursing
induced hypertension in acute progressive perforating artery stroke using peripheral dilute norepinephrine

Conditions: Stroke, Acute; Stroke, Ischemic

Summary: pressure is a multicenter, prospective, randomized, open, blinded end-point assessed (probe) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients with acute ischemic stroke in a perforating artery territory and experiencing early neurological deterioration.

perforating artery strokes represent 25% of all ischemic strokes and is a well-known cause of progressive symptoms : 12 to 36% of cases experience early neurological deterioration in hours or days after stroke onset. a possible mechanism is hypoperfusion due to lack of a rapid development of collateral flow because of the terminal distribution of perforating arteries. moreover, arterioles are maximally dilated within penumbra region, resulting in a cerebral autoregulation failure and a passive dependence of cerebral blood flow on arterial pressure. thus, induced-hypertension therapy by using vasopressive agents is an attractive therapy to increase the cerebral perfusion pressure and therefore restore blood flow in the ischemic penumbra.

Eligibility criteria:
inclusion criteria: * acute ischemic stroke \< 72 h in a perforating artery territory on brain mri * early neurological deterioration or fluctuation, attested by the neurologist in charge, defined by a ≥ 3-point increase in global nihss score or a 2-point increase on motor or ataxia score, whether this deterioration is transient or permanent. * time between early neurological deterioration and randomization \< 6 hours * age ≥ 18 years * contraception required in women of childbearing potential (intra-uterine device, hormonal contraception associated with inhibition of ovulation (combined or progestogen-only; oral, intravaginal or transdermal), female sterilization, vasectomised partner, sexual abstinence) * beneficiary of a health insurance system exclusion criteria: * - pre-stroke modified rankin score \> 3 * contraindication to brain magnetic resonance imaging (mri) * high risk of intracerebral hemorrhage: * cerebral microbleeds ≥ 10 * non traumatic focal superficial siderosis * hemorrhagic transformation of the present ischemic stroke * previous history of intracerebral hemorrhage (symptomatic or asymptomatic identified on brain mri) * intracranial vascular malformation or tumor with suspected risk of rupture or bleeding * prior intravenous thrombolysis \< 24 hours * requirement for anticoagulation in the first 7 days after randomization * systolic blood pressure (sbp) \> 180mmhg and/or mean arterial pressure (map) ≥ 110mmhg at inclusion * large artery atherosclerosis (ipsilateral atherosclerotic stenosis \> 50%), intra and extracranial dissection, or cardio-embolic stroke mechanisms * drugs with important interactions with norepinephrine: monoamine oxidase inhibitors (including reversible, non-selective agents such as linezolid), tricyclic antidepressants, entacapone. * pregnancy or breastfeeding
enhancing renal graft function during donor anesthesia

Conditions: Renal Failure Chronic; Transplant;Failure,Kidney; Anesthesia

Summary: renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. an optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. the aim of this study is to assess \& compare the effectiveness of 3 different modalities in this respect: mannitol, dopamine and adequate hydration.


Eligibility criteria:
inclusion criteria: * end-stage renal disease, for living-donor kidney transplantation exclusion criteria: * severe cardiac or hepatic dysfunction * coagulopathy

Keywords: mannitol dopamine perfusion renal graft donor anesthesia
phase iii bms-790052 add-on to peg-interferon alfa-2a and ribavirin in naive hepatitis c

Conditions: Hepatitis C

Summary: the purpose of this study is to compare the sustained virologic response at post treatment week 12 for each cohort (bms-790052/pegylated-interferon alfa 2a (pegifnα-2a)/ribavirin (rbv) versus placebo/pegifnα-2a/rbv).


Eligibility criteria:
inclusion criteria: * participants chronically infected with hcv genotype 4 * hcv rna viral load of ≥ 10,000 iu/ml * no previous exposure to an interferon formulation, rbv or hcv direct antiviral agent * results of a liver biopsy obtained within three years prior to enrollment to demonstrate the absence of cirrhosis. participants with compensated cirrhosis are permitted, however, and any prior biopsy is permitted exclusion criteria: * evidence of decompensated liver disease * documented or suspected hepatocellular carcinoma (hcc) * positive for hepatitis b surface antigen (hbsag) or human immunodeficiency virus-1 (hiv-1)/hiv-2 antibody at screening

Keywords: hepatitis c virus