Kornimate/medical-research-clean huggingface dataset:
crp,crp/alb ratio, n/l ratio in predictors of both systemic infection and survival in patient with sepsis in assiut university hospitals

Conditions: Sepsis; Systemic Infection

Summary: the goal of this study is to asses the value of biomarker (crp, crp/alb ratio, n/l ratio) in predictor of the outcome in normotensive patients with sepsis. the main question it aims to answer is: does biomarker (crp, crp/alb ratio, n/l ratio) can predict the outcome in patients with sepsis ?

sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. a hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is susceptible to nosocomial infection. a biomarker describes a measurable indicator of a patient\&#39;s clinical condition that can be measured accurately and reproducibly. biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis c-reactive protein (crp) is an acute-phase protein that is produced following stimulation by various cytokines in response to infection, ischemia, trauma, and other inflammatory conditions . high crp levels have been studied in relation to prognosis and mortality in critically ill patients . on the other hand, low serum albumin is known to be associated with poor prognosis and mortality . based on this knowledge, we speculated that the ratio of crp to albumin could be used as a predictive marker for mortality. recently, the crp/albumin ratio, a combination of markers for systemic inflammation and nutritional status, has been extensively studied as an independent prognostic marker in patients with infection, malignancy, and other diseases . however, there are relatively few studies conducted focusing on critical care patients in the icu among the plethora of biomarkers available to clinicians investigating septic patients in the emergency department (ed), white blood cell count (wbc) are always taken into consideration due to their availability and low cost. serial measurement of rp, is useful for clinicians' decision-making, as its serum levels correlate with the syndrome evo-lution .neutrophil-to-lymphocyte ratio (nlr) calculated from the complete blood count seems to be a reasonable tool for assessment during the sepsis course (8, 9).

Eligibility criteria:
inclusion criteria: * patients with sepsis with normal blood pressure exclusion criteria: * 1) patients with history of corticosteroid therapy or antibiotic use before admission. 2) patients with hematologic disorders, malignant diseases, chemotherapy or radiotherapy within the previous month . 3)patients with shock
local git hormones after bariatric maneuvers

Conditions: Morbid Obesity

Summary: background: many of the beneficial metabolic effects of bariatric surgery have been attributed to altered peptide hormone profiles, especially involving pancreatic and gut peptides. objectives: assess the effects of bariatric procedures (sleeve gastrectomy, minigastric bypass and sleeve gastrectomy with loop bipartition) on git hormones. methods: prospective randomized study which was carried out in the department of general surgery, minia university hospital during the period from february 2018 to february 2019. this study included 3 groups subjected to different operations; each group consisted of 50 patients.

prospective randomized study which was carried out in the department of general surgery, minia university hospital during the period from february 2018 to february 2019. this study included 3 groups subjected to different operations; each group consisted of 50 patients. age ranging from 20 to 50 years old and body weight ranging from 100 to 200 kg, and subjected to laparoscopic sleeve gastrectomy, mini gastric bypass and sleeve gastrectomy with loop bipartition. each patient was thoroughly evaluated by a multidisciplinary team (nutritionist, endocrinologist, psychologist, and surgeon) using a standardized protocol. follow up was done after two weeks and after 2 months.

Eligibility criteria:
inclusion criteria: all morbid obese patients - exclusion criteria: git diseases
real-life chronic rhinosinusitis outcome registry

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: an international consortium of leading medical experts in the field of chronic respiratory disease, the research team of galenus health and the non-profit organization euforea (european forum for research and education in allergy and airway diseases) has been conceived to conduct real-life outcome research. the galenus health digital platform consisting of a mobile application for patients and an online dashboard for physicians will be implemented in each of the participating centres. the data will be centralized in a pseudonymized database and will be the basis of the chronic rhinosinusitis outcome registry.

this real-life chronic rhinosinusitis outcome registry aims at longitudinal data collection from patients attending specialist care centres across europe. as primary aim it intends to provide new insights on the burden of uncontrolled disease, the impact on health-related quality of life, productivity loss as well as the effect of disease severity and co-morbid disease on these outcome parameters. in addition this outcome registry intends to identify patients eligible for type 2 targeted biologic therapy, evaluate treatment effectiveness and markers of treatment response. beyond that direct and indirect costs for society related to chronic rhinosinusitis and its' treatment will be studied.

Eligibility criteria:
inclusion criteria: * physician diagnosis of chronic rhinosinusitis * capable of using a mobile application on a smartphone exclusion criteria: * patients with malignancies of the sinonasal cavity * patients with inverted papilloma * patients with unilateral disease
relationships between anterior and condylar guidance - comparison by cbct and electronic axiography

Conditions: Temporomandibular Joint Disorders; Occlusion

Summary: the aim of the following study was to investigate the existence of a statistically significant correlation between the incisal features (incisal guidance angle, interincisal angle, overbite, overjet), temporomandibular joint (tmj) morphology and its function. the hypothesis was: i. the protrusive movement of the mandible does correlate with the tmj anatomy. ii. the protrusive movement of the mandible does not correlate with the incisal features. iii. the position and relationship of upper and lower permanent incisors do not have a direct and significant effect on the tmj morphology in young adults.

the study was based on anatomical and functional measurements of the parameters within the masticatory system. the study group was composed in a way that all the participants (age 20-24) had the temporomandibular joints fully developed and at the same time not yet modified by adaptive processes.

Eligibility criteria:
inclusion criteria: * 20-24 years old exclusion criteria: * history of trauma, orthodontic treatment or temporomandibular disorders
tens effect on gait and qol in stroke.

Conditions: Stroke

Summary: a study was conducted to investigate the additional effect of tens applied to acupuncture points to the physical therapy program on gait and quality of life in stroke patients. thirty stroke patients from both sexes aging from 40 to 65 years were randomly assigned into two equal groups: study group and control group. the study group received tens plus the designed physiotherapy program and the control group received only the same designed physiotherapy program. the outcome measures concerned with spasticity, gait and qol.

a rct study conducted to investigate the additional effect of tens applied to acupuncture points to the physical therapy program on gait and quality of life in stroke patients. the study was conducted at the outpatient clinic of faculty of physical therapy, cairo university and kasr el-ainy hospitals, faculty of medicine, cairo university, egypt. forty subjects were screened for eligibility but only thirty stroke patients from both sexes aging from 40 to 65 years who were included and randomly assigned into two equal groups: study and control group. the study group received tens plus the designed physiotherapy program and the control group received only the same designed physiotherapy program. patients were treated three times weekly for four weeks. the outcome measures included the modified ashworth scale (mas) for assessing spasticity, the whoqol-bref scale for evaluating qol and the biodex gait trainer for measuring the gait kinematics. evaluation of all variables took place pretreatment and post treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic stroke disease (6-8- months) * age 45-60 years old * mild to moderate spasticity * can walk 10 meters independently * sufficient cognitive abilities exclusion criteria: * other neurological diseases * severe spasticity * cognitive impairments * medical instability * sever arthritis or contractures * cardio-pulmonary disorders

Keywords: stroke spasticity tens acupuncture points gait quality of life
retrospective study of testicular cancer patients at the university magdeburg

Conditions: Testicular Cancer

Summary: retrospective analysis of treatment outcome and side effects of testicular cancer patients that had been diagnosed at the university magdeburg from 1960 until 2012.

creating an access windows form based data registry for testicular cancer patients. relevant data for testicular cancer patients based on eau-guidelines 2013 and eortc/rtog, lent-soma, ctc. all testicular cancer patients who had been histopathologically diagnosed al the institute of pathology at the university magdeburg. about 2000 patients from 1960 until 2012. postgraduate students collecting data requesting hospital documents, cancer registry of sachsen-anhalt, family practitioners and urologists as well as patients. statistically analysis with access and ibm spss statistics.

Eligibility criteria:
inclusion criteria: * testicular cancer histopathologically diagnosed at the university magdeburg germany exclusion criteria: * none.

Keywords: testicular cancer
febuxostat versus allopurinol control trial in subjects with gout

Conditions: Gout

Summary: the purpose of this study is to evaluate the safety and efficacy of febuxostat, once daily (qd), versus allopurinol in subjects with gout.

this was a randomized, controlled, double-blind study of 52 weeks duration. subjects receiving prior urate-lowering therapy underwent a 2-week washout period prior to randomization. subjects were then randomized to one of three treatment groups: febuxostat 80 milligram (mg), febuxostat 120 mg, or allopurinol 300 mg. naproxen (250 mg twice daily) or colchicine (0.6 mg once daily) was provided for prophylaxis of acute gout flares during the washout period and the first 8 weeks of double-blind treatment.

Eligibility criteria:
inclusion criteria: * meeting the preliminary criteria of the american rheumatism association for the classification of the acute arthritis of primary gout. * serum uric acid ≥ 8.0 milligrams per deciliter (mg/dl) at baseline exclusion criteria: * serum creatinine \>1.5 mg/dl * calculated creatinine clearance of \<50 milliliters per minutes (ml/min) * pregnancy or lactation; * concurrent therapy with urate lowering agents, azathioprine, 6-mercaptopurine, thiazide diuretics, or medications containing aspirin (\>325 mg) or other salicylates; * body mass index (bmi) \>50 kilogram per meter²(kg/m²); * a history of xanthinuria, active liver disease, or hepatic dysfunction; * a history of alcohol abuse or intake of 14 or more alcohol-containing drinks/week.

Keywords: uric acid xanthine oxidase tophi drug therapy
managing sleep-wake disruption due to hospitalisation: the circadian care project

Conditions: Circadian Rhythm Disorders

Summary: sleep is regulated by the interaction of homeostatic and circadian processes. the homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low sleep propensity in relation to dark/light cues, and is substantially independent of preceding sleep-wake behaviour. the circadian timing system encompasses a master clock in the brain and peripheral, ancillary time-keepers in virtually every organ of the body. in recent years, evidence has emerged that circadian disruption has serious medical consequences, including sleep loss, increased cardiovascular morbidity and increased risk of certain types of cancer. evidence is also emerging that hospitalization per se weakens circadian rhythmicity, due to disease itself and to modified light, food and activity cues. the aim of our project is to test an inpatient management system (circadiancare) that limits the circadian impact of hospitalisation by enhancing circadian rhythmicity through an assessment of the patient's specific circadian features/needs and an ad hoc, personalized light-dark, meal and activity schedule to cover the whole of the inpatient stay. this will be compared to standard inpatient management in terms of patients' perception, sleep-wake quality and timing during hospitalisation, inpatient utilization of sleep-inducing medication, length of hospitalisation, and prognosis (i.e. outcome of hospitalisation, subsequent hospitalisations and post-discharge sleep-wake disturbances). the circadiancare system is expected to benefit prognosis, decrease costs, and change the way hospitals are organized and designed in future, with potential direct relevance to the plans for the new university hospital of padova.


Eligibility criteria:
inclusion criteria: • hospitalized patients exclusion criteria: • absence of compliance
the cohort study of pediatric cataract

Conditions: Pediatric Cataract

Summary: this retrospective-prospective bidirectional cohort study aims to observe ocular parameter changes, different surgical/vision recovery strategies and postoperative adverse effects among young children with cataract. the influence on psychology and cognitive function will be taken into consideration as well.

pediatric cataract, one of the leading causes of childhood blindness globally, is complex and of great difficulty in treatment. pediatric patients with cataract (congenital, traumatic or complicated) are enrolled. in this study, investigators will compare ocular parameter changes, different surgical/vision timing or recovery strategies and adverse effects among young children （age \< 18 yo）before and after cataract surgery. the influence on psychology and cognitive function will be taken into consideration as well. the whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis. for children received cataract surgery, samples of partial anterior capsular tissue and 1 ml aqueous humor were collected during operation for further analysis. multimodal artificial intelligence analyses are performed to establish accurate diagnosis/treatment scheme and disease prediction model.

Eligibility criteria:
inclusion criteria: * aged \< 18 yo at the 1st visit unilateral or bilateral cataract agree to participant in this study and sign the informed consent exclusion criteria: * adults

Keywords: congenital cataract traumatic cataract complicated cataract ocular structure parameters surgical/vision recovery timing and strategies postoperative adverse effects psychologic and cognitive function artificial intelligence
the first puncture success rate of a novel injeq iq-tip™ system in pediatric lumbar punctures

Conditions: Lumbar Puncture

Summary: the investigation aims to demonstrate the first puncture success rate, as proxy of clinical benefit and clinical performance, of bioimpedance spectroscopy based spinal needle guidance method among pediatric hemato-oncology patients requiring lumbar punctures.

the primary purpose of the investigation is to demonstrate the claimed clinical benefit and safety of injeq iq-tip™ system. iq-tip™ is similar to common spinal needles with a custom-made stylet that enables the real-time bioimpedance measurement at the tip of the needle. the needle is connected to the analyzer device, which provides real-time csf detection during lumbar puncture from the very tip of the needle and by these means assists conducting the medical procedure. the investigation aims to demonstrate the first puncture success rate, as proxy of clinical benefit and clinical performance, of bioimpedance spectroscopy based spinal needle guidance method among pediatric hemato-oncology patients requiring lumbar punctures. the investigation is conducted in the pediatric hematology and oncology units of three finnish university hospitals

Eligibility criteria:
inclusion criteria: * pediatric hemato-oncology patients whose diagnosis or treatment plan requires lumbar puncture to acquire a csf sample or to inject drug or other substance * written and signed informed consent before the procedure from the parent and/or patient depending on the age of the patient exclusion criteria: * parents and/or patient refusal to participate or parents and/or patient unable to give informed consent * any contraindications to a lumbar puncture. contraindications include skin infection around the puncture area, unstable hemodynamics, bleeding tendency and increased intracranial pressure

Keywords: spinal puncture lumbar puncture
first time mothers and anal incontinence six years postpartum

Conditions: Fecal Incontinence; Urinary Incontinence; Quality of Life

Summary: previous studies show that incontinence is relatively common during pregnancy and after delivery. experiencing incontinence during pregnancy or in the first year after delivery increases the risk of long term incontinence. there is scarce documentation of the long term prevalence of anal incontinence (ai) in norway. this study aims to explore prevalence and risk factors for incontinence approximately six years after delivery among the 1718 who participated in two previous studies exploring the prevalence and predictors of anal incontinence in late pregnancy and during the first year after first delivery, and the effect of pelvic floor muscle exercises as treatment for anal incontinence after delivery. increased awareness and knowledge about risk factors and long term prevalence of anal incontinence among health professionals as well as pregnant and parous women may give indications about which women to target for preventative measures to reduce the risk of new onset of postpartum ai during pregnancy and after delivery. further, increased knowledge may aid in planning individualized follow-up during pregnancy and the first year as well as in the long term among women with existing ai symptoms.


Eligibility criteria:
inclusion criteria: * participants in previous studies exclusion criteria: * women not participating in previous studies
trial of endoscopy bipolar and argon of chronic rectal bleeding from radiation telangiectasias

Conditions: Radiation Injuries; Telangiectasis

Summary: aim: to compare the efficacy, safety and number of sessions of bipolar eletrocoagulation (bec) and argon plasma coagulation (apc) in the management of the bleeding telangiectasias from chronic radiation coloproctopathy (crcp). methods: thirty patients with active bleeding from telangiectasias were enrolled in two groups (15 bec and 15 apc) and classified according of saunders score. bec settings were 50 w and apc settings were 40 w and 1.0 l/min. colonoscopy was the first exam to rule out synchronous lesions and follow-up was performed with sigmoidoscopies. clinical cure was defined as cessation of bleeding and endoscopic cure was determined by absence of telangiectasias. failure was defined whenever more than 7 sessions or other therapy was necessary.

thirty patients with active and chronic hematochezia from radiation telangiectasias were randomized in two groups : * fifteen patients in group 1- bipolar eletrocoagulation (be) and * fifteen in group 2 - argon plasma coagulation(apc). for inclusion in the study, all patients were required to have active (at least one episode last week) and chronic (persist or appear 6 months after the conclusion of radiotherapy) rectal bleeding. between may 2005 and april 2008, patients were treated and followed at the endoscopy unit in the são paulo hospital (unifesp).

Eligibility criteria:
inclusion criteria: * active (at least one episode last week) and chronic (persist or appear 6 months after the conclusion of radiotherapy) rectal bleeding. * previous radiotherapy at least 6 months ago * presence of colonic or rectal telangiectasias * patients that agreed to participate of the study and signed the term of free consent and cleared exclusion criteria: * prior endoscopic treatment * rectal or colonic surgery * stenosis rectal * rectal bleeding before radiotherapy * severe cardiac disease

Keywords: radiation injuries telangiectasis bipolar eletrocoagulation argon plasma coagulation
gestrinone and endothelial function in young women

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to assess the association of hormonal implant with gestrinone in cardiovascular health outcomes in young women.

after being informed about the study, volunteers will be screened in accordance with eligibility criteria. eligible volunteers will be invited to appear to the research institute and participate in the study. all volunteers giving the written informed consent will perform all assessments in the same day at their visit.

Eligibility criteria:
inclusion criteria: * women; * between 25 and 45 years age; * history of ≥ 1 hormonal implant with gestrinone in the last 6 months or never had used any hormonal implants. exclusion criteria: * pregnancy; * menopause; * smoking; * moderate-high consumption of alcoholic beverages (above 14 drinks per week); * previous cardiovascular event (e.g. myocardial infarction and stroke); * uncontrolled psychiatric disease; * ventricular arrhythmia; * using antibiotics or corticoids; * regular contraceptive use (estrogen and progesterone); * use of illicit drugs.

Keywords: hormonal implant gestrinone endothelial function