Kornimate/medical-research-clean huggingface dataset:
exercise training in patients after bypass surgery

Conditions: Coronary Artery Bypass Surgery

Summary: based on clinical experience both physical condition and psychological recovery after surgery are individually variable. exercise training plays an important part, has been recommended for cabs patients in order to enhance recovery. regular exercise following cabs has shown that, in addition to the expected improvements in exercise capacity as a result of the surgery itself, patients who participate in cardiac rehabilitation can expect to see additional gains in exercise capacity and risk factor profiles. exercise training also increases personal self-esteem and self-confidence, can alleviate depression and fear, and increase the sense of well-being. the aim of this study was to examine the effects of supervised aerobic exercise training on pulmonary function, functional capacity, maximal exercise capacity, and anxiety in patients after coronary artery bypass surgery.

patients in the training group received supervised aerobic exercise training on the treadmill with the intensity of 60-75% of maximal vo2 for 40-50 minutes, 3 days a week for 8 weeks in a cardiac rehabilitation unit. work-load was gradually increased during eight-week period. each session had a five-minute warm-up and cool-down period. blood pressure and ecg were recorded during training sessions before exercise, at the third minute of each workload, after exercise, and during each minute of the recovery period. in addition, conventional chest physiotherapy and was instructed to continue their daily physical activity program at home patients in this group patients in the control group received no aerobic exercise training but were asked to continue their chest physiotherapy and daily physical activity program at home. the same researcher, who was blind to the group allocation, were evaluated all patients for pulmonary functions, respiratory muscle strength and submaximal functional capacity, exercise capacity, and anxiety level initially and after 8 weeks.

Eligibility criteria:
inclusion criteria: * male gender, * cabg surgery performed in the last one month, * patients with negative exercise test (on the 30 days after discharge). exclusion criteria: * valve surgery, * perioperative myocardial infarction assessed by electrocardiographic (ecg) and creatine kinase isoenzyme changes, * postoperative angina, diabetes mellitus, chronic renal failure, unstable angina, intermittent claudication, heart valve dysfunction (moderate or severe), severe cardiac arrhythmias, -presence of symptoms at rest or with minimal exertion, * chronic obstructive pulmonary disease (\>70% fev1/fvc), and * any disorder that might influence exercise performance physically (e.g. severe back pain, history stroke).

Keywords: coronary artery patients coronary artery bypass surgery respiratory muscle strength oxygen consumption aerobic exercise pulmonary function test maximal exercise test with oxygen consumption
frequency of perforated appendicitis in times of covid-19

Conditions: Perforated Appendicitis; Covid19

Summary: appendicitis is one of the most common clinical conditions in general surgery. the diagnosis is usually made from clinical examination, imaging (sonography or ct) and laboratory parameters. the laparoscopic appendectomy without drainage has established as the gold standard. patients usually leave the hospital two days after surgery. in times of corona crisis, patients are unsure to visit the hospital because of fear of infection with sars-cov-2. a higher incidence of perforated appendicitis could be an indicator for fear-related delay of going to the hospital. methods: investigators performed a retrospective analysis on the incidence of perforated appendicitis in a 10-week interval (mid-march to end of may) of the years 2018, 2019 and 2020 to evaluate possible changes in times of corona crisis. intraoperative findings, procedures, complications and the length of hospital stay were considered.

the local ethics committee of the university hospital of tübingen, germany, approved this study (az: 324/2020bo2). all patients treated for acute appendicitis in a ten week period from 16th of march to 31th of may in 2018, 2019 and 2020 were considered for the study. investigators analysed the frequency of perforated appendicitis in the periods indicated. informed consent was obtained from all individual participants. patient's records as well as database were analyzed for therapy specific items. definition perforation: perforated appendicitis was defined as described perforation in the surgical or pathological results. delay between onset of symptoms and first presentation at the hospital: patient's records were proved for self-declaration about the start of symptoms

Eligibility criteria:
inclusion criteria: * patients with acute appendicitis older than 16 years * appendectomy in time frame 16th of march to 30th of may in the years 2018, 2019 and 2020 exclusion criteria: * patients with acute appendicitis younger than 16 years * appendectomy not in the named time frames

Keywords: acute appendicitis, covid-19
safety and efficacy of an intrastromal transform corneal allograft (tca) for presbyopia correction - long term follow-up

Conditions: Presbyopia

Summary: the objective of this clinical study is to evaluate the long term safety and effectiveness of intrastromal implantation of the allotex transform corneal allograft (tca) for providing near vision in presbyopic subjects. a maximum of 101 eyes of qualified and consented subjects will undergo long term follow-up after instrastromal implantation of the tca for presbyopia.


Eligibility criteria:
inclusion criteria: * provide informed consent, have signed the written informed consent form, and been given a copy. * subjects must be willing and able to return for one scheduled follow-up examinations. * subjects must have undergone implantation with the tca under study protocol pro-010 between april 24, 2019 and october 31, 2019. exclusion criteria: • there are no known exclusion criteria.
intralesional versus intramuscular hepatitis b vaccine immunotherapy for warts

Conditions: Intralesional Versus Intramuscular Hepatitis B Vaccine for Multiple Common Warts

Summary: assessment of the effectiveness of intralesional and intramuscular hepatitis b vaccine in treatment of multiple common warts.

recently, intralesional immunotherapy by different antigens, including candida antigen and purified protein derivative ppd has been proved effective in the treatment of different types of warts. hepatitis b vaccine is one of the dna vaccines that are regarded as being potentially safer, relatively cheap and easy to produce with no special storage requirements because they are extremely stable and allow for potential simultaneous immunization against multiple antigens or pathogens via co-expression of multiple epitopes on single plasmid. hepatitis b vaccine could be a promising immunotherapeutic vaccine in the field of intralesional immunotherapy of warts. moreover, the efficacy of intramuscular injection of hepatitis b vaccine would be assessed and compared to its intralesional injection.

Eligibility criteria:
inclusion criteria: • adult patients of both sexes with multiple (\> 3 warts) common warts of various sites, sizes and duration, with or without distant warts after taking informed consent from all patients exclusion criteria: * pregnancy or lactation. * serious systemic or anaphylactic reaction to a prior dose of the vaccine or to any of its components. * allergic skin disorders such as generalized eczema and urticaria. * moderate or severe acute illness with or without fever. * previous wart therapy within 1 month prior to the study.
safety, tolerability, and pharmacokinetics of spl84 in healthy volunteers

Conditions: Cystic Fibrosis

Summary: this phase 1 study evaluated the safety, tolerability, and pharmacokinetics of spl84 single ascending doses (sad) in healthy volunteers (hv)


Eligibility criteria:
key inclusion criteria: * male adults 18 to 50 years old * considered healthy based on medical history, physical examination, 12-lead ecg and clinical laboratory results * body mass index (bmi) 19.0-30.0 kg/m2 * subjects who have no difficulties in receiving drugs by inhalation key exclusion criteria: * a major surgical procedure or significant traumatic injury within 28 days prior to study intervention administration * recent diagnosis of lung disease (\< 12 weeks from planned enrollment) * any acute illness (e.g. acute infection) within 48 hours prior to the study intervention administration, which is considered of clinical significance by the investigator. * chronic respiratory disease including but not limited to obstructive airway disease such as asthma or chronic obstructive pulmonary disease (copd); restrictive disease such as idiopathic pulmonary fibrosis (ipf); or pulmonary vascular disease such as pulmonary arterial hypertension (pah). * history of adverse reactions during aerosol delivery of any medicinal product. * total body weight ≤50 kg at screening. * abnormal forced expiratory volume at one second (fev1) at screening. * oxygen saturation ≤95% at screening. * alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma glutamyl transferase (ggt), alkaline phosphatase (alp) and bilirubin (total and direct) above upper limit of normal (uln) at screening and clinically significant * supine systolic blood pressure \ 140 mmhg, supine diastolic blood pressure \ 90 mmhg, heart rate \ 100 beats per minute (bpm), or elevated body temperature (\>38ºc) at screening * clinically significant ecg abnormalities at screening * positive for sars-cov-19 at screening or day -1 (baseline). * positive serology tests for human immunodeficiency virus (hiv), hepatitis b surface antigen (hbsag), and hepatitis c virus (hcv) antibody at screening. * positive urine drug, tobacco, and breath alcohol test result at screening or day -1 (baseline). * use of any prescription or over-the-counter (otc) medications, including vitamins and herbal or dietary supplements within 14 days prior to dosing. * subjects who have received any vaccines within 4 weeks prior to study intervention administration. * history or current drug/alcohol abuse (excluding use of medicinal cannabis for pain management). * history of smoking or vaping within 180 days (6 months) of screening
post-transplantation cyclophosphamide as gvhd prophylaxis after hsct

Conditions: Acute Myeloid Leukemia; Acute Lymphoid Leukemia; Lymphoma; Myelodysplastic Syndromes; Chronic Lymphocytic Leukemia; Immune System Diseases

Summary: this study evaluates the efficacy of high-dose post-transplantation cyclophosphomide as graft-versus-host disease (gvhd) prophylaxis after allogeneic stem cell transplantation in patients with different risk of gvhd. the risk-adapted strategy involves using single-agent cyclophosphomide in recipients of matched bone marrow graft, and combining cyclophosphomide with tacrolimus and mycophenolate mofetil in recipients of matched peripheral blood stem cells and mismatched bone marrow.


Eligibility criteria:
inclusion criteria: * patients must have an indication for allogeneic hematopoietic stem cell transplantation * signed informed consent * patients with a donor available. the donor and recipient must be identical at at least one allele of each of the following genetic loci: hla-a, hla-b, hla-cw, hla-drb1, and hla-dqb1. a minimum match of 5/10 is required for related donor. a minimum match of 8/10 is required for unrelated donor. * no second tumors * no severe concurrent illness exclusion criteria: * moderate or severe cardiac dysfunction, left ventricular ejection fraction \<50% * moderate or severe decrease in pulmonary function, fev1 \<70% or dlco\<70% of predicted * respiratory distress \>grade i * severe organ dysfunction: ast or alt \>5 upper normal limits, bilirubin \>1.5 upper normal limits, creatinine \>2 upper normal limits * creatinine clearance \< 60 ml/min * uncontrolled bacterial or fungal infection at the time of enrollment * requirement for vasopressor support at the time of enrollment * karnofsky index \<30% * pregnancy * somatic or psychiatric disorder making the patient unable to sign informed consent

Keywords: cyclophosphamide leukemia lymphoma myelodysplastic syndromes chronic lymphocytic leukemia immunosuppressive agents immune system diseases busulfan fludarabine tacrolimus mycophenolate mofetil antineoplastic agents, alkylating myeloablative agonists hematopoietic stem cell transplantation allogeneic
acute effects of passive and proprioceptive neuromuscular facilitation stretching techniques in youth basketball players

Conditions: Basketball Players; Stretching; Physical Performance

Summary: the aim of this clinical trial is to learn the acute effects of passive stretching and proprioceptive neuromuscular facilitation (pnf) stretching techniques on agility, speed and lower extremity explosive strength in young basketball players. it will also provide information about the comparison of two different stretching techniques. the main questions it aims to answer are: does passive stretching have positive acute effects on agility, speed and lower extremity explosive strength? does pnf stretching have positive acute effects on agility, speed and lower extremity explosive strength? the acute effects of passive stretching and pnf stretching on agility, speed and lower extremity explosive strength will be compared. participants: first tests were performed after the same warm-up program. then, one of the two different stretching techniques was applied and the same tests were repeated immediately afterwards.

the aim of this study was to examine the acute effects of static passive and proprioceptive neuromuscular facilitation (pnf) stretching techniques on agility, speed and lower extremity explosive power in youth basketball players. twenty male basketball players were randomized as passive and pnf groups. a single session of technique was applied to each group. outcome measurements consisted of the t agility test, 30-meter sprint test, standing long jump test, and lateral jump test.

Eligibility criteria:
inclusion criteria: * being male * being between 14-18 years of age * having at least 2 years of basketball experience * participated in regular team training for at least 2 months * having a body mass index of \&lt;29.9 kg/m2 exclusion criteria: * presence of pain and/or history of injury in the lower extremity within the last 6 months * history of orthopedic surgery of the lower extremity

Keywords: basketball players passive stretching pnf stretching
bipolar 15 charrières office resectoscope : polypectomy without anesthesia

Conditions: Polyps Uterus

Summary: this study aimed to the feasibility of polypectomy without anesthesia using a 15 ch. resectoscope in women with uterine polyps.

endometrial polyps are frequent gynecological pathologies leading to metrorrhagia, infertility, miscarriages and the risk of transformation into malignant pathology. the discovery of an endometrial polyp requires its removal. the treatment of endometrial polyps is conventionally carried out by hysteroscopic resection under general anesthesia with a bipolar resector of 22 charrières (ch) or more after dilation of the uterine cervix in the operating room. following the recent appearance of a 15 ch. bipolar mini-resectoscope, it seems that uterine dilation and anesthesia could be avoided by reducing the caliber of the instrument.

Eligibility criteria:
inclusion criteria: * female patients aged 18 or over * patients with 1 to 2 endometrial polyps * polyps diagnosed by ultrasound and / or diagnostic hysteroscopy following a check-up for menometrorrhagia, infertility or during a check-up * polyps measuring less than 3 cm * have signed a consent form * be affiliated with a health insurance plan. exclusion criteria: * pregnant or lactating patient * cervical stenosis * patient having more than 2 polyps * polyps measuring 3 cm or more * malignant cells on histology * associated indication of endometrectomy or other endo-uterine gesture * hypersensitivity to remifentanil or to other fentanyl derivatives or to any of the excipients of the specialty used * hypersensitivity to propofol or to any of the excipients of the specialty used * cardiac pathology * diaphragmatic hernia * morbid obesity (bmi\> 35) * invasive cervical cancer * chronic obstructive pulmonary disease * patient presenting a strictly greater than 4 on a pain scale (from 0 to 10) during a diagnostic hysteroscopy * does not speak and / or understand french * be deprived of liberty or under guardianship.
percutaneous trans-facet screw fixation under ct-scan guidance for remaining symptoms at a distance of previous spinal surgery

Conditions: Spinal Stenosis; Spinal Disease; Zygapophyseal Joint Arthritis; Joint Instability; Arthrodesis; Laminectomy; Post Laminectomy Syndrome

Summary: background : segmental spinal instability after a laminectomy, and adjacent segment disease (asd) at after an arthrodesis, are well-known concerns in spinal surgery, which may require re-interventions, usually by surgical arthrodesis, posing the problem of a new heavy intervention under general anesthesia, in often fragile patients. trans-facet fixation (tff) under local anesthesia and double fluoroscopic and ct guidance is a minimally invasive technique involving the placement of screws through the posterior facet joints, improving spinal stability. purpose : the aim of our study is to evaluate the efficacy, in terms of pain reduction (vas) and improvement of daily activities (odi), of tff under ct scan guidance in the context of low back pain and/or radiculalgia related to focal instability secondary to laminectomy or asd. methods : tff were performed in 24 patients having a history of spinal surgery such as laminectomy and/or classic surgical arthrodesis and remaining symptomatic, at nice university hospital between 2017 and 2021 pre- and postoperative pain and disability levels were measured using the visual analogue scale (vas) and the oswestry disability index (odi), collected prospectively at systematic 6-month and 1-year follow-up visits. long term evolution were assessed by phone consultation.


Eligibility criteria:
inclusion criterias : - patients treated at nice university hospital between 2017 and 2021 by transfacet arthrodesis, * history of spinal surgery ( laminectomy and/or classic arthrodesis) - clinical signs of subsequent instability(low back pain and/or radiculopathy). * mri or scintigraphy signs of instability or asd : * spondylolisthesis appeared or increased on successive exams * facet dislocation * subchondral bone changes of the vertebral endplates (modic 1) * insufficient improvment after epidural and posterior joint corticosteroid infiltrations
effects of caffeine on upper extremity performance

Conditions: Sportive Performance; Caffeine

Summary: it was aimed to apply caffeine supplement to elite basketball players and to investigate the effects of this supplement on upper extremity performance, lactic acid level and fatigue. the investigators also aimed to investigate the effects of blood lactate level on performance and fatigue.

the aim of this study is to examine the effects of caffeine supplementation on upper extremity performance, lactic acid and fatigue in elite basketball players and compare them with the placebo group. a total of 50 elite basketball players, 25 each in the caffeine and placebo groups, will participate in the study. caffeine supplement will be given 1 hour before the measurements (5mg/kg). muscular endurance before and after reinforcement, scapular muscular endurance test (sket); arm movement speed, disc touch test (ddt); anaerobic power, medicine ball throwing (stf); lactic acid (la) level will be evaluated by finger blood measurement and fatigue visual analog scale (vas).

Eligibility criteria:
inclusion criteria: * elite basketball players aged 19-44 * individuals with caffeine consumption below 2 mg per kg per day exclusion criteria: * individuals with systemic disease affecting the musculoskeletal system * individuals using supplements containing caffeine * individuals with any diagnosed neurological or orthopedic disease

Keywords: caffeine performance lactic acid basketball fatigue
an observational study of mabthera/rituxan (rituximab) in patients with rheumatoid arthritis and an inadequate response or intolerance to one anti-tumor necrosis factor (anti-tnf) agent

Conditions: Rheumatoid Arthritis

Summary: this observational, prospective, multicenter study will evaluate the efficacy and safety of mabthera/rituxan in participants with active rheumatoid arthritis and an inadequate response or intolerance to one anti-tnf therapy. participants who receive mabthera/rituxan according to the current standard and in line with the summary of product characteristics at a dose of 1000 milligram (mg) intravenously on days 1 and 15 will be followed for 20 weeks.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * participants with rheumatoid arthritis, eligible for treatment with mabthera/rituxan in accordance with summary of product characteristics (spc) * inadequate response to a single tnf inhibitor defined as change in disease activity score-28 erythrocyte sedimentation rate (das28-esr) \ 3.5 at 5 months after first course of anti-tnf therapy * participants with a clinical and biological evaluation performed within 12 weeks prior to enrollment may be included exclusion criteria: * more than one previous anti-tnf therapies * any other biological therapy apart from the one anti-tnf therapy * hypersensitivity to rituximab or any of the excipients or to murine proteins * active severe infections * participants in a severely immunocompromised state * severe heart failure \[new york heart association (nyha) class iv\] or severe, uncontrolled cardiac disease * women of childbearing potential not willing to use contraception * pregnant or breastfeeding women * participation in another trial
social anxiety disorder in medical students in sohag university

Conditions: Social Anxiety Disorder

Summary: the study will be done in sohag university to assess the prevalence and associated factors of social anxiety disorder among undergraduate medical students .

social anxiety disorder (sad) is highly prevalent and it's the most common anxiety disorder among all types of anxiety disorders and the third most common psychiatric condition after major depression and alcohol dependence. social anxiety disorder (sad) is characterized by persistent fear/anxiety about one or more social or performance situations in social settings. sad had a negative impact on learning ability, educational achievement, professional achievement, quality of life and social relationship \& may lead to substance abuse and depressive disorders.

Eligibility criteria:
inclusion criteria: * medical undergraduate students who are still studying for bachelor of medicine and bachelor of surgery ( m.b.b.ch ) . exclusion criteria: * students who will refuse to participate in this study .