Kornimate/medical-research-clean huggingface dataset:
hla and kir associations with infectious viral agents in an hiv cohort of women (wihs)

Conditions: HIV

Summary: since the beginning of the hiv/aids epidemic, the number of women infected with hiv has rapidly increased and is continuing to climb. the women's interagency hiv study is being conducted in several cities in the united states to learn more about how hiv affects women's lives and bodies. it will examine the role of hla and killer immunoglobulin-like receptors (kir) in hiv and related infections in hiv-positive and hiv-negative women. the study will determine the relationship between kir and hla genes and the following: the risk of hiv infection; hiv levels in the blood; incidence of aids; response to highly active antiretroviral therapy (haart); and response to immunotherapy. approximately 3,700 women will participate. participants will visit the clinic every 6 months for 4 years. an hiv test will be given each time to hiv-negative women. a questionnaire will also be administered. a physical examination and gynecological examination will be given. blood, vaginal swabs, and urine will be collected for testing. a biological impedance test will determine any changes in weight, waist-to-hip ratios, and breast and total body fat. low cd4 counts and hospitalizations for hiv are to be self-reported to study staff.

the aim of the study is to examine the role of hla and killer immunolobulin-like receptors (kir) in the natural history of hpv, hcv, and hbv in hiv-positive and hiv-negative women. the immune response to viral infection mediated by t lymphocytes is hla restricted, suggesting that hla class i, and class ii might be associated with risk of viral infection, persistence and disease progression. natural killer (nk) cells are a unique group of lymphocytes involved in surveillance and killing of foreign or infected cells through a mechanism involving recognition of hla molecules by an extremely diverse set of receptors on the nk cell surface. a major group of these receptors are the kirs. thus, a relationship between kir genotype and hiv infection is biologically plausible, and requires further investigation in observational studies. the wihs study is a prospective study, which may allow us to answer questions relating to the role of host hla and kir genotype on duration of infection, and the development of virus-associated diseases such as cervical cancer (related to hpv infection), and liver cancer (hbv and hcv). wihs is a large, racially and geographically diverse cohort of hiv positive (n = 2761), and risk-matched hiv-negative women (n = 942). the large size of the cohort will provide substantial statistical power, which is of major importance in any hla association study.

Eligibility criteria:
* inclusion criteria: dna and relevant clinical data from properly consented wihs subjects (maximum estimated at 3500) will be provided to our lab for genotyping and analysis. exclusion criteria: no available subjects will be excluded.

Keywords: genotyping hiv hpv hcv hbv
oversewing staple line of the gastric remnant

Conditions: Gastric Bypass; Obesity

Summary: background: roux-en-y gastric bypass (rygb) is a surgery with low rate complications. however, it is not exempt from them, and 1-6% suffer complications such as postoperative bleeding. many intraoperative techniques have been evaluated to reduce postoperative bleeding, like the oversewing or reinforcement of the staple line. this study aims to evaluate the rate of postoperative bleeding in the oversewing of the staple line of the gastric remnant group versus the stapling only group. methods: this is a 2-center, case-control study. the investigators randomly selected two groups who underwent rygb or oagb: group a (n=225) with oversewing from 2019-2020 and group b (n=225) with stapling only between the period of 2017-2018; both groups with similar demographic characteristics.

this case-control study was conducted in the international unit of bariatric and metabolic surgery of "clinica la sagrada familia" located in maracaibo, venezuela, and in "grupo medico santa paula" caracas, venezuela. all procedures were performed by a single experienced bariatric surgeon during the period 2017-2020. the ethics committees of clinica "la sagrada familia" and "grupo medico santa paula" approved this study. the investigators selected 225 patients (group a) from the period 2019-2020 where the stapling line of the gastric remnant was oversewn and another group of 225 patients (group b) from the period of 2017-2018 with stapling alone.

Eligibility criteria:
inclusion criteria: * our inclusion criteria were patients older than 18 years, body mass index (bmi) \> 30kg/m2 with or without comorbidities that underwent rygb or one anastomosis gastric bypass (oagb). exclusion criteria: * we exclude from our study any patient with psychiatric disorder, open surgery history, history of previous bariatric surgery, non-controlled comorbidity at the moment of surgery, and patients under the age of 18

Keywords: obesity
impact of exercise on prognostic biomarkers related to prostate cancer

Conditions: Prostatic Neoplasm

Summary: the goal of this study is to demonstrate the impact of a home based exercise program versus wait-list control to modulate circulating prognostic biomarkers in men with prostate cancer under active surveillance.

prostate cancer (pca) is the most common non-skin cancer effecting american males. several reports suggest that physical activity after cancer diagnosis is associated with better cancer- specific and overall survival in individuals diagnosed with pca. there is a growing body of evidence for lifestyle interventions that aim to promote physical activity as having the potential to counter some of the adverse effects of cancer treatments, disease progression and other health outcomes. exercise performed 2-3 times a week has been shown to improve physical fitness, functional performance, and quality of life in men with pca; however, few men with pca exercise regularly and do not meet national physical activity guidelines. a potential explanation on the lack of exercise in men with pca is the absence of a structured, home-based, exercise program. while studies have shown positive effects of exercise in men with pca, little is known about how physical activity effects tumor physiology in men with pca. the primary objective of this pilot study is to gather preliminary data regarding the impact of a novel, home-based exercise program on pca biomarkers associated with recurrence and metastasis of pca in men under active surveillance.

Eligibility criteria:
inclusion criteria: * men aged 40 or older * ambulating male * diagnosed with low grade prostate cancer * subjects willing and able to provide consent to participating in the study exclusion criteria * prostatectomy * severe cardiac disease (new york heart association class iii or greater) * angina * severe osteoporosis * uncontrolled hypertension (blood pressure \> 160/95mm hg) * uncontrolled sinus tachycardia (\> 120 beats per minute) * uncontrolled congestive heart failure third-degree atrio-ventricular heart block, active pericarditis or myocarditis, recent embolism, thrombophlebitis, deep vein thrombosis, resting st displacement (\> 3mm), uncontrolled diabetes, uncontrolled pain, cognitive impairment, history of falls due to balance impairment or lost of consciousness, * severe neuromusculoskeletal conditions that limit their ability to perform walking exercise (including ataxia, peripheral or sensory neuropathy, unstable bone lesion, severe arthritis, lower limb fractures within 6 months, lower limb amputation).

Keywords: prostate cancer biomarkers exercise
prognostic value of performance scores in patients undergoing surgery for upper tract urothelial carcinoma

Conditions: Carcinoma, Transitional Cell (RENI)

Summary: aim: to comprehensively evaluate the prognostic value of preoperative ecog-ps scores and asa scores in patients undergoing radical nephroureterectomy (rnu) for upper tract urothelial carcinoma. methods: multicentered cohort study

background: the eastern cooperative oncology group (ecog) performance status (ps) score and the american society of anesthesiologists (asa) score are essential tools for the assessment of patients with various malignancies. however, doubts have arisen regarding their prognostic utility due to conflicting findings in limited studies. this study aims to comprehensively evaluate the prognostic value of preoperative ecog-ps scores and asa scores in patients undergoing radical nephroureterectomy (rnu) for upper tract urothelial carcinoma. materials and methods: this multicentered cohort study enrolled patients who underwent rnu with curative intentat sixteen institutes in taiwan from 1988 to 2023. univariable and multivariable regression analyses were used to determine the impact of ecog-ps scores and asa scores on survival outcomes and postoperative complications. patients were categorized based on ecog-ps scores (0-1 vs. 2-4) and asa scores (1-2 vs.3-4) according to prior literature.

Eligibility criteria:
inclusion criteria: * all patients received utuc surgery and follow-up in sixteen institutions across taiwan exclusion criteria: * treatment not aimed at curative intent * incomplete data
prediction of cephalosporinase producing enterobacteria during ventilator-associated pneumonia for therapeutic stewardship

Conditions: Ventilator Associated Pneumonia

Summary: ventilator-associated pneumonia is the leading cause of nosocomial infection in the icu. cephalosporinase-producing enterobacteriaceae have an increasing incidence. infections in cephalosporinase-producing patients require the use of cefepime during probabilistic antibiotic therapy, the repeated use of which will lead to a significant risk of selection of resistant mutants. the involvement of cephalosporinases being infrequent, the prediction of their presence during a vap would make it possible to reduce the consumption of cefepime and thus to take part in the prevention of selection of bacterial mutants resistant to beta-lactams. the main objective of the research is to determine the risk factors for the involvement of cephalosporinase-producing enterobacteria during episodes of ventilator-associated pneumonia (vap) in hospitalized patients. the secondary objectives are to describe the epidemiology of cephalosporinase-producing enterobacteria in the icu and to compare the risk factors for the presence of a cephalosporinase-producing germ not without its production being derepressed with those present in situations of cephalosporinase derepression.


Eligibility criteria:
inclusion criteria: * patient 18 years and older * patient on mechanical ventilation for more than 48 hours * patient with a diagnosis of ventilator-associated lung disease during management according to american thoracic society criteria * french speaking patient exclusion criteria: * tracheostomized patient at the time of inclusion * limitation of therapies before inclusion in the study * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of his/her data for this research
evaluation of program for length based weight estimation

Conditions: Length-based Weight Estimation; Body Weights and Measures

Summary: the purpose of this prospective single center study is to investigate if a developed program is more accurate than the anesthesia tape ("anästhesie-lineal"). for this study 1000 patients are required to collect anonymized data (length, weight, age, anesthesia material used during anesthesia) for achieving a power of 80% during statistical analysis. the main hypothesis ist that the program has a better accuracy than the anesthesia tape ("anästhesie-lineal").

this prospective single center study is performed at the university children's hospital zurich. patients planned for surgery in general anesthesia with intubation, aged 0 to 16 years and with a body length suitable for the emergency tapes can be included in this study. patient and parental information is performed during the pre-anesthetic visit. after written consent the patient will be included. patient ́s length and weight will be measures earliest one day before data collection. data collection during anesthesia has no influence on the daily anesthesia routine and has no impact on patient safety and anaesthesia. patient's data is made anonymous for further inspection. data is documented in microsoft excel and statistical analysis calculated with spss. 1000 patients are needed for a power of 80%. primary outcome parameter is length based weight estimation, secondary outcome parameters are length based age estimation and the correctness of recommended anesthesia material (endotracheal tube, laryngeal mask, oropharyngeal mask and face mask). both tools (program and anesthesia tape \["anästhesie-lineal"\]) will be compared with each other regarding primary and secondary outcome parameters.

Eligibility criteria:
inclusion criteria: * body length suitable with the investigated emergency tapes * all patients aged 0 -16 years * receiving general anesthesia with intubation or laryngeal mask exclusion criteria: * already included in this study once * missing patient or parental consent

Keywords: weight estimation patient safety
breathomics: may it become an affordable, new tool for early diagnosis and screening of lung cancer?

Conditions: Lung Cancer

Summary: breath analysis examining specific patterns of volatile organic compounds (vocs) has been demonstrated to be able to discriminate lung cancer (lc) patients from healthy controls (hc). however, the existing technology uses complex, expensive, and low throughput analytical platforms to give an offline response, thus preventing its applicability for mass screening. the reliability of a new portable device to enable rapid, on-site lc diagnosis is tested.

the breath of patients with histologically proven nsclc and healthy controls was sampled into tedlar bags through a nafion filter and a one-way mouthpiece. the breath samples in the bags were then analyzed by an automated micro portable gas chromatography device developed in-house, which consisted of a thermal desorption tube, thermal injector, separation column, and photoionization detector, as well as other accessories such as pumps, valves, and a helium cartridge. the chromatograms were analyzed by chemometrics and machine learning techniques.

Eligibility criteria:
inclusion criteria: * nsclc histologically proven (for lc group) at any stage of disease * non-cancer controls who had negative findings on preoperative chest x-rays/chest ct scan (for hc groups) exclusion criteria: * patients who had any history of another type of cancer * who had received neoadjuvant chemo/radiotherapy because of the possible unknown effects on cancer metabolism * pediatric patients.

Keywords: breathomic nsclc screening volatile organic compounds
nasolacrimal sac biopsy in endoscopic dacryocystorhinostomy

Conditions: Dacryocystitis; Chronic

Summary: during dacryocystorhinostomy (dcr), the lacrimal sac wall biopsy is not routinely performed, but it is recommended if there is a suspicion of underlying disease other than preoperatively or intraoperatively chronic inflammation. we aimed to evaluate the utility of the histopathology examination of fifty patients in alazhar hospitals to put recommendation for histopathology examination of such cases.

most of patient with epiphora have different causes of nasolacrimal duct obstruction . this study aims to examine how important routine lacrimal sac biopsy is during endoscopic dacryocystorhinostomy surgery. the study included 50 patients with chronic unilateral epiphora. all patients underwent endoscopic dacryocystorhinostomy with nasolacrimal duct biopsy. histopathologic analysis was performed for each specimen to assess the nature of the pathology.

Eligibility criteria:
inclusion criteria: - male and female patients with chronic lacrimal duct obstruction attended the outpatient clinic of the hospital for treatment during the study period. exclusion criteria: * patients refusing the biopsy * patients asked for histopathology in private laboratories
a study to compare pk/pd characteristics and safety profiles between ad-120 and ad-120a

Conditions: Gastroesophageal Reflux Disease (GERD)

Summary: primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of ad-120 in healthy subjects.

the purpose of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics and safety profiles of ad-120 compared with ad-120a in healthy subjects.

Eligibility criteria:
inclusion criteria: * body weight equal to or greater than 50.0kg and equal to or less than 90.0kg and body mass index (bmi) between 18.5 kg/m2 and 29.9 kg/m2 at the time of screening visit * the age equal to or greater than 19 and equal to or less than 50 in healthy volunteers at the time of screening visit * negative result from serum helicobacter pylori antibody at the time of screening visit exclusion criteria: * patients with trouble performing ph monitor catheter
fecal microbium change in pediatric patients with spina bifida: prospective case-control study

Conditions: Spina Bifida

Summary: purpose: in order to verify the hypothesis that the composition of intestinal microbiota in children with spina bifida is different from that of normal control, prospective comparative analysis would be performed. background of the study: spina bifida is a congenital neurological disorder, causing neurogenic bowel. it has been known that the intestinal microbiota in spinal cord injury patient was different than that of control. changes in intestinal motility, mucous secretion, immune surveillance, and epithelial barrier permeability are possible causes of this change. as spina bifida is also related with neurogenic bowel, the investigators hypothesized that the intestinal microbiota in spina bifida is different from that of normal control. patients total 30 patients and 10 controls inclusion for patients patients who meet following conditions: 1) children over 3 years old and under 12 years old who have been diagnosed with spinal bifida with spinal mri exclusion for patients and controls 1) children with known inflammatory bowel disease or cloacal anomaly statistical analysis statistical processing for fecal samples is aimed at alpha or beta diversity using bioinformatics, and the kruskal-wallis test is used to compare similarities or differences between each fecal sample. prior to statistical analysis, the relative abundance of the detected microorganisms is analyzed first, and microorganisms having a distribution less than 0.1% are excluded from the analysis, and the remaining microorganisms are analyzed in the 'genus' step.


Eligibility criteria:
inclusion criteria: * 1. children aged 3-12 years, diagnosed with spina bifida in spinal mri. exclusion criteria: * 1. the patient has an inflammatory intestinal disease known in the colon or has a cloacal anomaly.
safety and efficacy study of a eye drop for eye allergy

Conditions: Allergic Conjunctivitis

Summary: the purpose of this study is to evaluate the efficacy and safety of an anti-allergy eyedrop.


Eligibility criteria:
inclusion criteria: * at least 10 years of age * positive history of ocular allergies * positive skin test reaction to allergens. exclusion criteria: * known allergy, contraindication, or sensitivities to the use of any of the study medication(s) or their components * ocular surgical intervention within three (3) months prior to visit 1 or during the study * known history of retinal detachment, diabetic retinopathy, or progressive retinal disease, or glaucoma * any other significant illness
rapid on-site cytopathologic evaluation in the diagnosis of hilar/mediastinal adenopathy

Conditions: Lung Cancer; Sarcoidosis; Tuberculosis

Summary: the purpose of this study is to determine whether rapid on-site cytopathologic evaluation (rose) can increase the diagnostic yield of transbronchial needle aspiration (tbna) in the diagnosis of hilar and mediastinal lymphadenopathy.


Eligibility criteria:
inclusion criteria: * 18 years old and older * hilar and/or mediastinal lymphadenopathy (\> 1 cm on the short axis, as assessed by contrast-enhanced ct scan (computed tomography)) exclusion criteria: * uncontrolled coagulopathy * refusal to sign informed consent

Keywords: transbronchial needle aspiration bronchoscopy rapid on-site cytopathologic evaluation mediastinal lymphadenopathy hilar lymphadenopathy
transrectal ultrasound (trus) in finding tumors during robotic-assisted laparoscopic surgery

Conditions: Prostate Cancer

Summary: this pilot clinical trial studies mechanically-manipulated ultrasound in finding tumors during robotic-assisted surgery in patients with prostate cancer. diagnostic procedures, such as ultrasound, may help find prostate cancer and find out how far the disease has spread during surgery

primary objectives: i. to assess the feasibility and limitations of using a mechanically-manipulated transrectal ultrasound (trus) probe for trus evaluation during a da vinci robotic-assisted laparoscopic prostatectomy (ralp). ii. to collect trus evaluation data during ralp to guide us in deciding whether and how the mechanical manipulation of the trus probe will allow sufficient clarity of ultrasound imaging. outline: patients undergo trus during ralp. after the completion of study treatment, patients are followed up at 7 days.

Eligibility criteria:
inclusion criteria: * undergoing robotic assisted laparoscopic prostatectomy exclusion criteria: * known or discovered rectal pathology * bleeding hemorrhoids * rectal stenosis * any prior rectal surgeries * prior rectal radiation * any known rectal disease
investigation of the perception of protein fortified foods and beverages

Conditions: Individual Difference; Food Sensitivity; Food Preferences

Summary: this study aims to investigate whether protein fortification of foods and beverages causes mouthdrying and mucoadhesion and whether this is influenced by age and saliva flow.

1. to investigate, by using protein fortified foods and beverages, whether mucoadhesion to the oral cavity is greater for older adults compared to younger adults and determine whether it is related to salivary flow rate. 2. to determine whether protein fortification of foods and beverages causes mouthdrying and whether perception and acceptance are influenced by age and individual differences in saliva flow. these aims will be investigated using two different models: a liquid model using whey protein and a solid model using protein fortified biscuits and cakes.

Eligibility criteria:
inclusion criteria: * age 18-30 years or over 65 years * self reported as healthy (no specific disease states) exclusion criteria: * cognitively impaired * allergies or intolerances that include coeliac disease, lactose or gluten intolerance * diabetic * had oral surgery * had stroke * smoker

Keywords: older adults oral nutritional supplements saliva flow mucoadhesion mouthdrying