Kornimate/medical-research-clean huggingface dataset:
angiotensin-converting enzyme (ace)-inhibition and mechanisms of skeletal muscle weakness in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: a double blind randomised placebo controlled parallel trial of the effect of fosinopril, an angiotensin converting enzyme inhibitor, on the quadriceps muscle in 80 copd patients who have quadriceps weakness. patients will have a baseline assessment including measures of quadriceps strength and endurance and a quadriceps biopsy. patients with weakness will be randomised to ace inhibitor or placebo and re-assessed after three months of treatment. the investigators aim to show that ace-inhibition will alter the igf-1/akt/foxo/atrogene pathways involved in muscle wasting in copd.


Eligibility criteria:
inclusion criteria: * adult patient with copd diagnosed according to gold criteria. exclusion criteria: * clinically unstable patients (within one month of exacerbation), those with a permanent pacemaker (which is a contraindication to magnetic stimulation), or significant co-morbidity, patients with an accepted indication for ace inhibition (left ventricular dysfunction, diabetes) or a contraindication such as renovascular disease; creatinine clearance (estimated) \<50); hypotension; use of anticoagulants (contra-indication to biopsy) or ace-i or atii receptor antagonists. * allergy to ace-inhibitors. * pregnancy. patients will not be enrolled within three months of participation in a pulmonary rehabilitation program.
fass (facial action summary score) scale to differentiate the pain of postoperative anxiety in children under 7 years

Conditions: Postoperative Pain

Summary: this study aims to evaluate the psychometric validity of fass (facial summary score scale) to assess postoperative children pain.


Eligibility criteria:
inclusion criteria: * children surgery * younger than 7 years old * elective surgery * patient whose parents will have given their non-opposition exclusion criteria: * psychological retardation * chronic pain

Keywords: psychometric validity pain scale postoperative children
impact of nesiritide infusion for decompensated heart failure in the emergency department

Conditions: Heart Failure, Congestive; Cardiomyopathy

Summary: the purpose of this study is to determine if an 8hr infusion of nesiritide in the emergency department in the acutely decompensated heart failure patients will decrease 30 day recidivism.

in view of the high return admission rate to our county ed for heart failure, we hypothesized that our higher risk patient population might realize a decrease in the return admission rate as a benefit from early ed administration of nesiritide. we also acknowledged that the safety of nesiritide in our patient population had not been well established. thus, we opted to test the hypothesis that an 8-hour ed infusion of nesiritide \[in addition to protocol specified standard therapy\] in adhf patients from an urban patient population consisting of predominately african americans and hispanics will decrease 30-day readmission rates without provoking harm.

Eligibility criteria:
inclusion criteria: * patients who were adults greater than 18 years of age * a history of established heart failure * dyspnea at rest or with minimal exertion and with a respiratory rate greater than 24 breaths per minute * evidence of volume overload based on physical exam findings or chest radiograph, and a brain natriuretic peptide (bnp) level greater than 100 pg/ml. exclusion criteria: * systolic blood pressure of less than 90 mm hg * frank or impending cardiogenic shock * cardiopulmonary arrest * evidence of low cardiac output (cold clammy extremities * mental status changes) * new onset congestive heart failure * suspected acute coronary syndrome (elevated troponin, new electrocardiographic changes, or history consistent with cardiac ischemia) * high clinical suspicion of pulmonary embolism * end-stage renal disease (on dialysis or imminent) * active use of nitroglycerin or inotropic infusions in the ed * ventricular tachycardia * allergy to nesiritide or its components * patient not needing intravenously diuretic therapy in the ed * normal bnp level * inability to follow-up * pregnancy or suspected pregnancy; or * actively receiving other investigational drug.

Keywords: chf heart failure dyspnea cardiomyopathy
single-incision sling vs urethral bulking during prolapse surgery for occult stress incontinence

Conditions: Stress Incontinence, Female

Summary: the aim is to compare outcomes of two different procedures to prevent occult stress urinary incontinence (sui) in patients who are having pelvic organ prolapse surgeries

the aim is to compare outcomes of two different procedures to prevent occult stress urinary incontinence (sui) in patients who are having pelvic organ prolapse surgeries. charts will be reviewed for patients who had single- incision sling or urethral bulking injection with other prolapse surgeries to address occult stress incontinence at the christ hospital from the period of january 2019 to june 2021. patients who didn't have any occult stress incontinence pre-operatively and didn't receive any anti-incontinence procedure during their prolapse surgery will be included as a control group. surgical details, adverse events and postoperative voiding times will be collected from the chart. patients will be contacted by a telephone to administer a validated questionnaire; a 3-day bladder diary to quantify urinary incontinence will be send to the patient to complete and return by mail. the purpose of the study is to investigate whether urethral bulking is as effective as single- incision sling in treating occult stress incontinence.

Eligibility criteria:
inclusion criteria: * -females who are 18 years or old who were scheduled to either urethral bulking (bulkamid) or single-incision sling (altis sling) to address occult sui with prolapse surgery. all patients reported no history of sui preoperatively and during office physical exam, positive sui was demonstrated during prolapse reduction. * females who are 18 years or old who didn't have occult stress incontinence before their prolapse surgery and didn't receive any stress incontinence surgery during their prolapse surgery during the same period will be included as a control group. * english speaking patients. exclusion criteria: * patients who had either single-incision sling or urethral bulking with documented preoperative history of stress incontinence. patients with a history of previous surgery for sui.
familial mediterranean fever and behçet: analysis before and after covid19 pandemic

Conditions: Behcet Disease; COVID; FMF

Summary: behcet' disease (bd) is a chronic inflammatory disease which is characterized by oral and genital ulcers, uveitis and skin lesions. musculoskeletal involvement such as arthrits, arthralgia, enthesis and sacroiliitis can be seen in course of bd. fmf is an autosomal recessive family disease characterized by abdominal pain, chest pain, joint pain and fever attacks as a result of inflammation of the serous membranes. fmf patients have been shown to experience higher levels of pain, fatigue, depression and anxiety than healthy controls, and this has increased sleep disturbance and reduced quality of life. fmf and bih have common characteristics such as ethnicity, etiopathogenetic mechanisms, symptoms, and treatment. in december 2019, after the officially detected coronavirus (severe acute respiratory syndrome coranavirus-2 \[sars-cov-2\]) resistant to unknown treatment and rapidly spreading coronavirus in our country on march 11, 2020 in hubei province of china, the number of cases increased rapidly and virus was isolated in 670 patients within 10 days. ongoing concerns about the spread of covid-19 infections have caused many measures to be taken. among them, social isolation, home quarantine and avoiding collective places are the most important. in our country, in the process of social isolation, the areas of movement of behçet and fmf patients, like everyone else, were restricted, their stress and anxiety levels increased and their motivation decreased. the aim of our study is to compare the pain, sleep, fatigue, physical activity level and quality of life and question exercise habits before and after the covid-19 outbreak in patients with behçet and fmf.


Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * being diagnosed with fmf at least 1 year ago according to diagnostic criteria * a diagnosis of bih at least 1 year ago according to the international behçet working group * having signed the informed consent form * having a cooperative level that will respond to evaluation scales exclusion criteria: * pregnant women * having other chronic diseases * psychiatric disorders and treated * those with cognitive impairment
study evaluating prevenar in high-risk children

Conditions: Pneumococcal Disease

Summary: the purpose of this study is to estimate the local and systemic tolerability of prevenar in children ages 2 to 5 years old in usual care settings.


Eligibility criteria:
inclusion criteria: * high-risk children ages 2 to 5 years old exclusion criteria: * prior administration of prevenar * prior and/or concurrent administration of 23 vps vaccine

Keywords: children vaccine prevenar
serum and tissue level of interleukin-15 (il-15) and il-15 receptor alpha (il-15rα) in mycosis fungoides

Conditions: Mycosis Fungoides

Summary: estimation of serum and tissue level of il-15 and il-15 r α in mycosis fungoides prior to after treatment.

twenty patients will be recruited from the cutaneous lymphoma clinic who are either recently diagnosed with mf or presenting with recurrent mf following cessation of treatment. an informed written consent will be obtained from all patients. clinical assessment: patients will be assessed clinically for extent by bsa as well as mf staging and type. for mf staging, in addition to extent, diagnostic skin biopsies will be assessed for depth of the infiltrate. radiological assessment including chest x-ray, pelvi-abdominal ultrasound as well as lymph node examination, ultrasound and biopsy if required. biochemical assessment including complete blood count, liver and kidney function tests, lipid profile as well as lactate dehydrogenase and beta 2 microglobulin. standardized photographs will be taken at initial assessment as well as following resolution of the biopsied lesion. baseline biochemical assessment at the beginning of the study: serum samples as well as 4mm lesional punch skin biopsies will be taken prior to starting phototherapy treatment to assess serum and tissue level of il-15 and il-15 r α level using enzyme-linked immunosorbent assay (elisa). phototherapy treatment: patients with superficial lymphocytic infiltrate will be assigned to either nb-uvb sessions, while those with deep infiltrate will be assigned to puva. patients will undergo thrice weekly sessions. patients will be clinically assessed on monthly basis to monitor response to treatment and record any side effects. biochemical reassessment: serum and lesional biopsies will be retaken following resolution of the biopsied lesion to assess serum and tissue level of il-15 and il-15 r α level using enzyme-linked immunosorbent assay (elisa). afterwards, the biopsied lesion will be covered if the patients was having other unresolved lesions and monthly follow up will be carried to detect lesional recurrence. any reported recurrence during the estimated study duration of 6 months will be re assessed for both serum and tissue level of il-15 and il-15 r α level using enzyme-linked immunosorbent assay (elisa). twenty healthy controls will be recruited and assessed for both serum and tissue level of il-15 and il-15 r α level using enzyme-linked immunosorbent assay (elisa).

Eligibility criteria:
inclusion criteria: * subjects with mycosis fungoides; newly diagnosed or recurrent after cessation of treatment exclusion criteria: * patients with any contraindication to phototherapy (e.g., any other skin cancers or photosensitivity); or to psoralen (e.g., liver disease). * subjects with history of solid or hematological malignancy as leukemia. * patients with autoimmune disease as sle. * patients who received treatment for the past one month. * pregnant and lactating females.
ldk378 in crizotinib naïve adult patients with alk-activated non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: a single-arm, open-label, two-stage multicenter, phase ii study. patients were pre-screened for alk positive status. treatment with ldk378 at 750 mg qd was continued until the patient experienced unacceptable toxicity that precluded further treatment, discontinued treatment at the discretion of the investigator or patient, started a new anticancer therapy and/or died. ldk378 was continued beyond recist defined progressive disease (pd) as assessed by the investigator, if in the judgment of the investigator, there was evidence of clinical benefit. patients who discontinued the study medication in the absence of progression continued to be followed for tumor assessment until the time of pd as assessed by the investigator. male and female patients aged 18 or over with alk-rearranged non-small cell cancer (nsclc) were screened for eligibility. patients had to have received no prior crizotinib, and had to be chemotherapy-naïve or been pretreated with cytotoxic chemotherapy (up to three prior lines).


Eligibility criteria:
key inclusion criteria: * histologically or cytologically confirmed diagnosis of stage iiib or iv nsclc that carried an alk rearrangement, as per the fda-approved vysis alk break-apart fish assay (abbott molecular inc.) * age 18 years or older at the time of informed consent. * patients must have nsclc that had progressed during or after the last chemotherapy regimen received prior to the first dose of ldk378, if chemotherapy was received * patients must have been chemotherapy-naive or had received 1-3 lines of cytotoxic chemotherapy to treat their locally advanced or metastatic nsclc * patients must have had a tumor tissue sample available, collected either at the time of diagnosis of nsclc or any time since. * patients must have recovered from all toxicities related to prior anticancer therapies to grade ≤ 2, except for patients with grade 2 nausea/vomiting and/or grade 2 diarrhea despite optimal supportive therapy who were not allowed to participate in the study. key exclusion criteria: * prior treatment with crizotinib, or any other alk inhibitor investigational agent, for nsclc * patients with known hypersensitivity to any of the excipients of ldk378. * patients with symptomatic central nervous system (cns) metastases who were neurologically unstable or had required increasing doses of steroids within the 2 weeks prior to study entry to manage cns symptoms. * history of carcinomatous meningitis. * presence or history of a malignant disease other than nsclc that has been diagnosed and/or required therapy within the past 3 years. * clinically significant, uncontrolled heart disease.

Keywords: non-small cell lung cancer non small cell lung carcinoma nsclc alk ldk378 ceritinib crizotinib naïve adult patients alk-activated non-small cell lung cancer treatment of lung cancer after first metastasis lung cancer lung adenocarcinoma
does electrocautery increase postoperative pain in primary total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: total knee arthroplasty (tka) is a successful treatment for end-stage osteoarthritis of the knee. the main advantages of tka are to relieve the pain of the knee, improve the knee function, restore lower limb alignment, and improve the quality of life for patients. during tka, some surgeons prefer using a scalpel while others using electrocautery to expose the articular cavity. whether the use of scalpel can lead to better and faster recovery after the primary tka is still controversial. the aim of this study was to compare the clinical outcomes of using the scalpel and the electrocautery in primary tka

a randomized controlled trial of patients underwent primary tka between october 2021 and october 2023. the groups will be determined by using the computer to generate a randomization lists. a total 132 patients were included with 66 patients in the scalpel group, 66 patients in the electrocautery group. all patients were evaluated using primary outcome : post-operative visual analog scale (vas) of pain, secondary outcome: estimated blood loss and knee injury and osteoarthritis outcome score (koos-jr)

Eligibility criteria:
inclusion criteria: * osteoarthritis patient (kl classification gr 2-4) * primary tka * varus deformity \< 20 degree * flexion contracture \< 20 degree exclusion criteria: * coagulopathy * platelet dysfunction * inflammatory arthritis * revision tka

Keywords: total knee arthroplasty, electrocautery, scalpel, post-operative pain, pain score
a pilot study of mindfulness intervention to the timing of labor admission, uncertainty and anxiety

Conditions: Anxiety; Uncertain Viability of Pregnancy

Summary: the goal of this quasi-experienmental study is to investigate the effectiveness of mindfulness-based intervention in the level of uncertainty and anxiety, and determintation towards hospital admission among pregnant women. the main questions : • do pregnant women in intervention group reduce anxiety and uncertainty? • do pregnant women in intervention group increase self-determintation ability towards hospital admission? women in the intervention group participated 4 weeks mindfulness-based intervention online courses, researchers have seen effectiveness of mindfulness-based intervention in the level of uncertainty, anxiety, and determintation towards hospital admission among pregnant women.

the aim of this study is to investigate the effectiness of mindfulness-based intervention in the level of uncertainty and anxiety, and determination towards hospital admission among pregnant women. this study is a quasi-experimental design and convenient sampling to recruit primipara women in the distrct hospital. a total of 31 participants were enrolled, eleven participatns were assigned to the experimental group, and twenty participants were in the control group. the measurements were demographic characteristics andobstetric data, ffmq,vas of uncertainty and anxiety, and acs.

Eligibility criteria:
inclusion criteria: 1. at least 20 years old. 2. single primiparous women with gestation over 28 weeks. 3. clear consciousness, ability to speak, write and read chinese, able to write questionnaires by themselves. 4. those who are expected to have a vaginal delivery. 5. agree to participate in the researcher after the research description. exclusion criteria: 1. people with mental health problems, such as: depression, mental illness, etc. 2. the woman has pregnancy complications or the fetus has any complications. 3. arrange for labor induction. 4. those who have meditated or attended mindfulness courses.

Keywords: mindfulness-based intervention childbirth related anxiety childbirth related uncertainty
early versus late use of hi-vni in covid-19

Conditions: COVID-19

Summary: this study evaluate early administration of high-velocity nasal insufflation in covid-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of non re-breathing mask where early use of high velocity nasal insufflations achieved better improvement of respiratory distress, lower oxygen requirements and shorter icu stay.

the study included 30 covid-19 patients admitted to intensive care of covid-19 zone, chest department, quarantine section, assiut university hospital. all patients were positive for covid-19 infection by nasopharyngeal swab for detection of viral rna by real time pcr for sar-cov-2 rna assay on 7500 applied bio-system. all patients received treatment based on the protocol of egyptian ministry of health, patients enrolled in the study were categorized into 2 groups, the 1st group included patients whom were shifted to hi-vni after failure of high flow nasal cannula, while the 2nd group included patients shifted to hi-vni after failure of non-rebreathing mask, using a precision flow vapotherm (vapotherm, inc, 100 domain device exeter, nh 03833, t: 603-658-0011, usa), that provide high velocity humidified flow through narrow bore nasl prongs

Eligibility criteria:
inclusion criteria: * 1-severe covid patients with hypoxemic respiratory failure. 2- patients with no comorbidities exclusion criteria: 1. non severe covid patients 2. patients with comorbidities (e.g chronic chest dis, dm, renal failure and hepatic failure 3. patients indicated for mechanical ventilation 4. patients with marked hypercapnia in need for non-invasive ventilation

Keywords: hi-vni covid-19
effect of psychoeducation on motivation to change in traumatized alcoholics

Conditions: Alcoholic Intoxication, Chronic

Summary: many people suffering from alcohol dependence have a history of exposure to stressful life situations, such as childhood physical or emotional misuse. often, there's a functional relationship between drinking and emotional problems related to past traumatic experiences, i.e. drinking to forget. however, alcohol treatment often does not include interventions to support patients to cope better with past life experiences. on the other hand, most alcoholics are poorly motivated to participate in long-term rehabilitative treatments after detoxification. in the proposed study, the investigators will study the effects of a brief psycho-educational group intervention during detoxification treatment on motivation to change and the willingness to accept further treatment. the investigators will use a group comparison design (intervention versus "tas" control group). in month 1, patients take part in treatment as usual (tas), including a unspecific information group. in month 2, the information group is replaced by the psychoeducational group (intervention). ward staff selects patients for the groups, irrespective of intervention or tas. selection criteria are: absence of severe withdrawal and cognitive impairment. absence of severe co-morbid psychiatric disorder (e.g. schizophrenia or suicidal crisis). the group sessions will take place in groups of up to 15 patients and will include 4 structured sessions (45 min each). main content if the intervention group is to highlight and discuss the association between stress, posttraumatic stress disorder and drinking. patients will also be informed about the different treatment options available in the region. at entry, patients are asked to fill in the german versions of the university of rhode island change assessment (urica; mcconnaughy, prochaska, \& velicer, 1983; german: heidenreich, hoyer \& fecht; 2001) and the trauma history questionnaire (thq; green, 1996; german: maercker, 2002). at discharge, patients are asked to fill in the urica. the investigators expect that specific information on the association between stress and drinking will increase the patients' motivation to participate in further treatment.


Eligibility criteria:
inclusion criteria: * alcohol dependence * regular admission to detoxification unit exclusion criteria: * severe withdrawal * severe cognitive impairment * severe comorbid psychiatric conditions (schizophrenia, suicidal crisis)

Keywords: psychoeducation group control