Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of white spot lesions treated by s-prg material and composite sealants in comparison with icon

Conditions: White Spot Lesions

Summary: dental caries is the primary cause of tooth loss and oral diseases. dental decay is a continuous pathological process with loss of tooth minerals, demineralization, which involves the destruction of tooth structure from acids. the first sign of early active demineralization is white spot lesions (wsls) on the tooth surface, meanwhile, subsurface active mineral decomposition.

deposition of minerals depends on the equilibrium between demineralization and remineralization which may happen as a natural repair mechanism. the aim of this trial is to comparatively evaluate the efficacy of surface pre-reacted glass filler (s-prg) barrier coat coating material against the icon resin infiltration in the ability to improve the caries lesion state of the wsls along 1 year. laser fluorescence was used to compare the two materials to evaluate the caries progression. prg barrier coat group showed immediate significant improvement in lf scores in demineralization progress and inhibition of caries progression with a significant improved effect. s-prg barrier coat was clinically successful strategy in inhibition of caries and improve remineralization.

Eligibility criteria:
inclusion criteria: * patients within 20-40 years of age. * each patient has 4 or more wsls. * mild and moderate wsls according to gorelick's scale. * good oral hygiene and willing patients who can attend the study visits. * a symmetrical number of permanent teeth in each arch (mesial to second molars). exclusion criteria: * active carious lesions. * facial surface restorations. * intrinsic and extrinsic stains. * patients who have a significant medical history or if they smoke. * criteria for discontinuation; mortality and acquiring severe debilitating disease
german multicenter trial for treatment of newly diagnosed acute lymphoblastic leukemia in adults (06/99)

Conditions: Adult Acute Lymphocytic Leukemia

Summary: the study evaluates the efficacy and tolerability of an intensified induction and consolidation therapy. thereafter patients receive individualised treatment stratified according to relapse risk with stem cell transplantation for patients with high and very high risk of relapse. patients with standard risk receive further consolidation and reinduction chemotherapy. in parallel minimal residual disease (mrd) is evaluated. a mrd based risk stratification and treatment decision is developed.


Eligibility criteria:
inclusion criteria: * acute lymphoblastic leukemia (pro-b, common, pre-b, early t, t) * age 15-65 yrs (\*55-65 years if biologically younger according to general condition) exclusion criteria: * severe comorbidity * cytostatic pre-treatment * pregnancy * missing written informed consent

Keywords: all treatment de novo adult
sargramostim to prevent mucositis in patients receiving radiation therapy for laryngeal cancer

Conditions: Head and Neck Cancer; Oral Complications; Radiation Toxicity

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. drugs such as sargramostim may protect normal cells from the side effects of radiation therapy. purpose: randomized phase ii trial to determine the effectiveness of sargramostim in preventing mucositis in patients who are receiving radiation therapy for laryngeal cancer.

objectives: * determine the efficacy of sargramostim (gm-csf) in reducing the duration and severity of mucositis resulting from accelerated radiotherapy in patients with laryngeal carcinoma. * determine the effect of gm-csf on quality of life aspects of these patients as assessed by nutritional status, analgesic use, and days in the hospital. outline: this is a randomized study. patients receive radiotherapy in 16 fractions over 21 days. patients are randomly allocated to one of two treatment arms before scheduled radiotherapy begins. * arm i: patients receive sargramostim (gm-csf) sc daily for 14 days beginning on day 14 of the course of radiotherapy. * arm ii: patients do not receive gm-csf. patients are followed weekly until mucositis is healed, as well as at weeks 2 and 6 following the end of radiotherapy. projected accrual: a total of 34 patients (17 per arm) will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of laryngeal cancer with intention to treat by radiotherapy using a 16 fraction 3 week scheme * stage i or ii * no known cns disease patient characteristics: age: * 20 to 80 performance status: * who 0-1 life expectancy: * not specified hematopoietic: * not specified hepatic: * hepatic function normal renal: * renal function normal other: * not pregnant or nursing * no serious active infection requiring antibiotic therapy * no autoimmune disease * no known seizures * no psychosocial factors that would preclude study compliance * no allergies to sargramostim (gm-csf) * willingness to cooperate for regular mirror examination of the larynx prior concurrent therapy: biologic therapy: * no concurrent immunotherapy chemotherapy: * no concurrent chemotherapy endocrine therapy: * no prior or concurrent corticosteroids * no concurrent hormonal therapy radiotherapy: * see disease characteristics surgery: * no major organ allografts other: * no other concurrent investigational drugs

Keywords: stage i laryngeal cancer stage ii laryngeal cancer recurrent laryngeal cancer oral complications radiation toxicity
circulating lymphatic progenitor cell and lymph node metastasis

Conditions: Ovarian Cancer

Summary: correlation of circulating lymphatic endothelial progenitor cells with lymph node metastasis

correlation of circulating lymphatic endothelial progenitor cells with lymph node metastasis in ovarian cancer patients

Eligibility criteria:
inclusion criteria: * ovarian cancer patients diagnosed by pathologic examination exclusion criteria: * other malignant disease inflammatory disease untreated diabetic and hypertension chronic renal failure rheumatoid arthritis
the effectiveness and safety of dong-a opalmon® tablet in patients with acquired lumbar spinal stenosis

Conditions: Lumbar Spinal Stenosis

Summary: this study is to evaluate the effectiveness and safety of dong-a opalmon® tablet in patients with acquired lumbar spinal stenosis


Eligibility criteria:
inclusion criteria: * men or women aged ≥ 19 years * subjects with acquired lumbar spinal stenosis who show normal results in the straight leg raising (slr) test and exhibit intermittent claudication, requiring treatment with dong-a opalmon® tab * subjects who voluntarily consent to participate in this observational study exclusion criteria: * subject for whom the medicinal products administration is contraindicated according to the approved domestic drug information: pregnant women or those who may be pregnant, subject with genetic disorders such as galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption * subjects considered as unsuitable for participation in this observational study by the principal investigator or sub-investigator
hydrotherapy intervention in elderly with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis is a common condition characterized by pain and functional disability in older people. prevalence increases with age and is more frequent in older women. the aim of this study was to assess the effects of an 8-weeks hydrotherapy training with elastic bands on pain and functional disability in old people with knee osteoarthritis.

the main symptoms of knee osteoarthritis are pain and functional disability. these symptoms are caused by a progressive loss and deterioration of articular cartilage with reactive new bone formation at the joint's surface and margins involving articular cartilage, soft tissues and bone damage. many treatment programs have been developed, including medication with nonsteroidal anti-inflammatory drugs, physical modalities, and therapeutic exercises. it is hypothesized that a hydrotherapy treatment during 8 weeks would benefit patients with knee osteoarthritis.

Eligibility criteria:
inclusion criteria: * confirmed clinical diagnosis of knee osteoarthritis exclusion criteria: * total knee arthroplasty * inability to co-operate or follow instructions. * a major neurological disorder

Keywords: knee osteoarthritis hydrotherapy
pd4pd:partnered dance for parkinson disease

Conditions: Parkinson Disease

Summary: exercise is often noted as an important component in a comprehensive approach to the management of parkinson disease (pd). most studies of exercise have examined the effects of short-term interventions and have tested participants on their anti-parkinson medications. as such, these studies have not been able to determine whether or not exercise may have a disease-modifying effect in people with pd. the investigators recent work has shown the potential benefits of dance as a form of exercise for individuals with pd, but, like previous work, has only examined short-term interventions. the investigators think that dance may be ideally suited for study over a longer period of time because dance incorporates many of the features recommended for inclusion in pd-specific exercise programs in a format that is known to be engaging and to enhance motivation to participate in healthful behaviors. as such, the investigators aim to determine both the short- and long-term effectiveness of a community-based dance program for individuals with parkinson disease and to determine how physical function changes over time in individuals with pd who do not exercise as compared to those who exercise regularly. the investigators hypothesize that: a) participation in dance will result in improved physical function, cognitive function, mood and quality of life in people with pd within 3 months, b) additional improvements will be noted at 6 months as compared to 3 months, c) improvements will be maintained at one year with continued, regular participation in a dance class, d) those who do not exercise will show significant functional decline over a period of one year, a decline that will not be present in those who dance regularly.


Eligibility criteria:
inclusion criteria: * normal central and peripheral neurological function * at least grade 4/5 strength and normal joint ranges of motion in both legs, - vision corrected to 20/40 or better * able to walk independently for 10 feet with or without an assistive device, - normal somatosensory function in the feet (2-point discrimination, vibration, joint kinesthesia, and light touch) * no history of vestibular disease exclusion criteria: * serious medical problem * evidence of abnormality other than pd-related changes on brain imaging (previously done for clinical evaluations-not part of this research) * history or evidence of neurological deficit other than pd that could interfere, such as previous stroke or muscle disease * history or evidence of orthopedic, muscular, or psychological problem

Keywords: exercise parkinson disease motor symptoms gait balance
prospective observational study on the incidence of opportunistic fungal infections

Conditions: Pneumocystis Jirovecii Infection; Pneumocystis; Cryptococcosis; Candidiasis; Aspergillosis

Summary: corticosteroids exposure is a common risk factor for invasive fungal infections. systemic corticosteroid therapy treats several medical conditions, including rejection in solid organ transplant recipients, malignancy, and autoimmune or inflammatory diseases. corticosteroid exposure is a well-known risk factor for developing pjp. still, it remains unclear how prior corticosteroid exposure influences the presentation, severity, and mortality of opportunistic fungal infections. the investigators aim to prospectively characterize the corticosteroid use as a dose response to inform risk of invasive fungal infections.

the investigators will use trinetx, a global federated research network that captures anonymous data from electronic medical records (emrs) of 66 healthcare organizations. the investigators are setting up a prospective observation study of non-hiv, non-transplant (nhnt) patients who are receiving systemic (oral or intravenous) corticosteroids for more than 2 weeks. the investigators are planning on excluding individuals younger than 18 years old with any prior history of cryptococcosis, aspergillosis, pneumocystis jirovecii pneumonia or invasive candidiasis. the investigators will follow 3 cohorts of patients based on their daily cumulative prednisone equivalent dose in mg. group 1: 0-10 mg a day, group 2: 10-20 mg a day, group 3: \> 20 mg daily. the investigators will record any incidence of cryptococcosis, aspergillosis, pneumocystis jirovecii pneumonia or invasive candidiasis based on icd-10 codes or labs results at 3-6 months intervals. the investigators will record as well additional clinical features for patients including demographics, comorbidities, medications, and limited labs.

Eligibility criteria:
inclusion criteria: * patients on systemic corticosteroids for more than 2 weeks exclusion criteria: * hiv infection * transplant status * younger than 18 years of age * previous history of cryptococcosis, aspergillosis, pneumocystis jirovecii pneumonia or invasive candidiasis

Keywords: immunocompetent corticosteroids pneumocystis carinii pneumocystis jirovecii mortality hiv-negative patients
alcohol and tobacco consumption in patients with head and neck cancer : interest of an addiction support

Conditions: Head and Neck Cancer; Lung Cancer

Summary: this is a multicenter, interventional, randomized study for preventive and therapeutic strategies for patients with head and neck or lung cancer; contribution of an addiction support


Eligibility criteria:
inclusion criteria: * first head and neck or lung cancer * first support * 18 ≤ age ≤ 60 * lives in lille metropolis * having an addiction to alcohol and tobacco * covered by health insurance * signed informed consent exclusion criteria: * prior cancer * mesothelioma and oesophageal cancer * unable to undergo trail medical follow up (geographical, social and psychological reasons) * pregnant or nursing woman * patient under guardianship

Keywords: addiction support addiction specialist lung cancer head and neck cancer
effect of brain gym exercises on postural stability in children with down syndrome

Conditions: Down Syndrome

Summary: this study will be conducted to detect the effect of brain gym exercises on postural stability in children with down syndrome .

evaluation procedures: history of the patients was carefully taken to collect data about their general conditions, physical activity and current medication. the procedures of this study were divided in the following main parts: -preparatory procedures: * all medical and demographic data of subjects will be collected * the role of physical therapy importance in improving their life will be explained. * the basic vital signs of all patients will be monitored (bp, temperature, respiratory rate, and hr). * the patients will be instructed to report any side effects during the treatment sessions . explained to the children and to their parents, before conducting the study. all the participants were screened (examined) according to inclusion and exclusion criteria. then met the parents of the participants, told them about the study, and received a written approval from them . all the children were firstly screened for balance deficit (static , dynamic and functional balance) by using * single leg stance test (sls) for static balance assessment * timed up and go test (tug) for dynamic balance assessment * paediatric balance scale (pbs) for functional balance assessment * the assessment and the treatment program, were conducted for each child individually, before and after the treatment period. assessment : * single leg stance test (sls) for static balance assessment * timed up and go test (tug) for dynamic balance assessment * paediatric balance scale (pbs) for functional balance assessment ttt : group a will receive brain gym exercises and physiotherapy, while group (b) will receive physiotherapy alone. brain gym exercises will be applied for 12 weeks , 3 per week . therapist will ask the child to drink a cup of water ,then investigators apply these exercises : cross crawl - elephant - belly breathing -the owl - arm activation -positive points - energizer - foot flex - neck rolls -the grounder -brain buttons -hook up sitting position - thinking caps- lazy eights - the rocker-calf pump - the gravity glider exercise.

Eligibility criteria:
inclusion criteria: - child characteristics: * their age ranged from six to twelve years. * both genders will be included. * all children were mentally sub-normal and they were able to understand the command that will give to them (iq ranged from 60 - 70) according to the national research centre reports. * their weight and height will be within normal ranges. * they were able to stand on the balance check system and maintain stability on it. exclusion criteria: hildren with ds, who might have one or more of the following will be excluded: * children with severe mental retardation. * children who have any associated disorders or any congenital abnormalities that may affect balance. * children with visual defects that can affect their performance. * obese children.

Keywords: brain gym exercises postural stability
characterization of the fungal origins in the autoimmune polyendocrinopathy of type 1 compared with the autoimmune polyendocrinopathies of type 2

Conditions: Polyendocrinopathies, Autoimmune

Summary: autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (apeced) is an autosomal recessive disease caused by mutations in the autoimmune regulator (aire) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (cmc), hypoparathyroidism, and adrenal insufficiency. cmc can be complicated by systemic candidiasis or oral squamous cell carcinomas (sccs) and may lead to death. the role of chronic candida infection in the etiopathogenesis of oral scc is unclear. long term use of fluconazole lead to emergence of c. albicans strains with azoles decreased susceptibility. cmc is associated with an impaired th17 cell response, however, it remains unclear whether decreased serum il-17 and il-22 levels are related to a defect in cytokine production or to neutralizing autoantibodies resulting from mutations in the aire gene


Eligibility criteria:
inclusion criteria: 1. for both of groups, inclusion criteria are : * children aged 0 to 17 years old with the consent of both parents, and men and women between the ages of 18 and 85. * a reasonable delay of 2 weeks after the resolution of an intercurrent infectious episode is to be observed. * assent of the patient after information adapted to his age and his degree of understanding. * informed, express and written consent of the patient or of each of the holders of parental authority. 2. inclusion criteria specific to group 1: patients with a aps type 1 whose molecular diagnosis (mutation of the aire gene) has been established in the diagnosis of the disease, regardless of their mycological status (history of mycosis) or the presence of antifungal treatment. 3. inclusion criteria specific to group 2 : patients with aps type 2: - with adrenal insufficiency for 50% of them. - a delay of two weeks after stopping antifungal or antibiotic treatment in patients is to be respected. exclusion criteria: * impossibility to receive informed information for adults, or impossibility to receive enlightened information for the holders of parental authority if minor subject * inability to participate in the entire study, refusal to sign the consent. * people in an emergency situation. * persons deprived of their liberty. * pregnant or lactating woman (pregnant women will be offered to participate in the study after delivery).

Keywords: apeced syndrome autoimmune polyendocrinopathy chronic mucocutaneous candidiasis
comparison of dir-mri and dce-mri in detection of prostate cancer: a pilot study

Conditions: Cancer of the Prostate

Summary: this is a pilot study taking place at university hospitals of north midlands nhs trust. patients referred for mri for possible prostate cancer will be invited to take part in the study. following consent, participants will have an additional mri sequence performed during their routine mri called double inversion magnetic resonance imaging (dir-mri). participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team.

this is a pilot study taking place at university hospitals of north midlands nhs trust. patients referred for mri for possible prostate cancer will be invited to take part in the study. following consent, participants will have an additional mri sequence performed during their routine mri called double inversion magnetic resonance imaging (dir-mri). participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team. the research team will look at the variability of lnr score amongst the two scan typed and the dce-mri and dir-mri images will be correlated with biopsy results to give an indication of the accuracy.

Eligibility criteria:
inclusion criteria: * patients referred for prostate mri for possible prostate cancer * safe to undergo an mri scan * able to give informed consent exclusion criteria: * mri referrals where prostate cancer is not the question * patients who are not safe to undergo an mri scan * patients who have undergone prostate biopsy in the previous 10 weeks * patients unable to give informed consent

Keywords: prostate cancer mri
computed tomography (ct) in head and neck patients

Conditions: Lung Tumors

Summary: this study is conducting a comparison of chest x-ray (cxr) and minimum dose thoracic ct (mndct) in the detection of lung nodules (metastases) in patients with head and neck carcinoma.

a comparison of chest x-ray (cxr) and minimum dose thoracic ct (mndct)in the detection of lung nodules (metastases) in patients with head and neck carcinoma

Eligibility criteria:
inclusion criteria: * patients with squamous cell carcinoma of the head and neck exclusion criteria: * none
education and counseling program on patients with cieds and low hl

Conditions: Arrhythmias, Cardiac; Heart Failure; Health Knowledge, Attitudes, Practice

Summary: the goal of this rct (randomized controlled trial) is to investigate the effect of education and counseling program that researches developed on patients with cardiac implantable electronic devices (cieds) and low health literacy. the main questions are; is there a difference between the health literacy scores of intervention and control groups after education and counseling program? is there a difference between the cieds knowledge scores of intervention and control groups after education and counseling program? is there a difference between the daily life activity scores of intervention and control groups after education and counseling program? researches offer an education and counseling program about living with cieds to patients that having cieds for the first time. participants answers questions in health literacy survey european questionnaire 16, cardiac implantable electronic devices knowledge scale (researches developed) and duke activity index before education and counseling program, at first month, third month and sixth month after implantation. reseraches compare scores between intervention and control groups, also different times in same groups.


Eligibility criteria:
inclusion criteria: * no communication problems in turkish * implanted any type of cied for the first time * having low score of hls eu q16 * willingness to participate in the study exclusion criteria: * not literate * having vision or hearing problem * having psychiatric and cognitive impairment