Kornimate/medical-research-clean huggingface dataset:
immunization of hla-a201 patients with metastatic melanoma using a combination of immunodominant peptides from three melanoma antigens, mart-1, gp100 and tyrosinase

Conditions: Melanoma; Neoplasm Metastasis

Summary: this is a study of a melanoma tumor antigen peptide vaccine. peptides representing hla-a201 restricted t cell epitopes of the melanoma antigens, mart-1, gp100 and tyrosinase will be administered emulsified in incomplete freund's adjuvant, (ifa) to hla-a201 patients with melanoma. the study is designed to evaluate the potential therapeutic role, immunologic effects and toxicity of repeated doses of this peptide vaccine administered subcutaneously. immune reactivity to the peptide epitope will be monitored in all patients by analysis of melanoma-specific t cell precursors prior to and after immunization.

this is a study of a melanoma tumor antigen peptide vaccine. peptides representing hla-a201 restricted t cell epitopes of the melanoma antigens, mart-1, gp100 and tyrosinase will be administered emulsified in incomplete freund's adjuvant, (ifa) to hla-a201 patients with melanoma. the study is designed to evaluate the potential therapeutic role, immunologic effects and toxicity of repeated doses of this peptide vaccine administered subcutaneously. immune reactivity to the peptide epitope will be monitored in all patients by analysis of melanoma-specific t cell precursors prior to and after immunization.

Eligibility criteria:
any patient 16 years of age or older with measurable metastatic melanoma who has failed standard treatment and has an expected survival of greater than three months. must be hla-a0201. serum creatinine of 2.0 mg/dl or less. bilirubin 1.6 mg/dl or less. wbc 3000/mm(3) or greater. platelet count 90,000 mm(3) or greater. serum ast/alt less then two times normal. ecog performance status of 0 or 1. patients of both genders must be willing to practice effective birth control during the trial. must not be undergoing or have undergone in the past 3 weeks any other form of therapy except surgery for their cancer. must not have active systemic infections, coagulation disorders, or other major medical illnesses of the cardiovascular or respiratory systems or any known immunodeficiency disease. must not require steroid therapy. must not be pregnant. must not be positive for hepatitis b(s)ag or hiv antibody. must not have had a known allergic reaction to incomplete freund's adjuvant (ifa).

Keywords: cancer il-12 il-2 immunotherapy vaccine
a study to evaluate continuous glucose monitor in hospitalized, post-operative patients with diabetes mellitus

Conditions: Diabetes Mellitus

Summary: the purposes of this study is to study if cgms worn in the postoperative icu or non-icu hospital setting have adequate accuracy for blood glucose monitoring when compared to point-of-care (poc) capillary glucometers.

eligible patients will be approached by research staff either preoperatively or on the first 5 days post-surgery and offered to be enrolled. if agreed to participate, they will be fitted with a blinded cgm monitor (dexcom g6 pro) as soon as they are awake and alert after the surgery. they will continue to have their blood glucose check as usual in the icu and on surgical floors with poc glucometers. on discharge, or at the end of the first cgm sensor life, the sensor will be removed and sensor data will be analyzed. cgm data will be compared with point-of-care blood glucose monitoring obtained in the hospital.

Eligibility criteria:
inclusion criteria: * patients with type 1 or 2 diabetes mellitus. * patients 18 years of age or older. * admitted for deceased donor renal transplant surgery, pancreas transplant surgery, heart transplant surgery, liver transplant surgery and lung transplant surgery. * anticipated minimum of 72h hospital stay. * patients on insulin therapy (iv, sq) post-surgery. exclusion criteria: * active covid-19 infection. * pregnant or lactating female. * altered mental status at the time of sensor placement (sensor will be placed once mental status will improve). * inability to provide informed consent. * patients taking more than 4 g of acetaminophen in 24 hours or more than 1 gm every 6 hours. patients with skin lesions at the application site that may interfere with placement of the sensor. patients with known allergy to medical grade adhesive.
radiation-protection effect of amifostine in locally advanced rectal cancer

Conditions: Locally Advanced Rectal Cancer

Summary: the study evaluates the addition of amifostine to capecitabine and irinotecan in neoadjuvant chemoradiation(crt) in locally advanced rectal cancer. half of participants will receive capecitabine and along with neoadjuvant radiotherapy, followed by a cycle of xeliri, while the others will receive capecitabine and irinotecan added by amifostine during crt, followed by a cycle of xeliri. all participants will be scheduled to receive surgery 6-8 weeks after the completion of crt. then it will depends which regimens the patient would receive according to his or her pathological results.


Eligibility criteria:
inclusion criteria: * pathological confirmed adenocarcinoma * clinical stage t3-4 and/or n+ * the distance from anal verge less than 12 cm * without distance metastases * performance status score: 0\~1 * ugt1a1\*28 6/6 or 6/7 * without previous anti-cancer therapy * sign the inform consent exclusion criteria: * pregnancy or breast-feeding women * serious medical illness * baseline blood and biochemical indicators do not meet the following criteria: neutrophils≥1.5×10\^9/l, hb≥90g/l, plt≥100×10\^9/l, alt/ast ≤2.5 uln, cr≤ 1 uln * dpd deficiency * ugt1a1\*28 7/7

Keywords: neoadjuvant chemoradiotherapy amifostine irinotecan capecitabine
investigating handwriting characteristics and underlying factor in children with autism spectrum disorder

Conditions: Children With Autism Spectrum Disorder; Typical Developed Children

Summary: the mechanism of the motor problem in children with autism spectrum disorder (asd) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related underlying factors, and investigating corresponding brain activities. this study aimed to investigate the underlying factor of handwriting issue in children with asd. there are four study aims. the first is to examine the differences of handwriting performance between children with asd and td using kinetic and kinematic measurements and handwriting difficulties questionnaires. the second is to investigate the group difference of the underlying motor factors, including fine motor ability and sensorimotor ability. the third is to explore the relationship between underlying motor factors and handwriting performance. the fourth is to explore the corresponding cortical activity during writing in children.


Eligibility criteria:
inclusion criteria: * age between 5-12 years old exclusion criteria: * who have a diagnosis of a seizure disorder, genetic condition, neurological condition, uncorrected significant hearing or visual impairment, and/or intellectual disability * having non-verbal intelligent ability score lower than 70, determining by toni-3 * unable to follow instructions during the process

Keywords: autism handwriting kinetic and kinematic cortical activation sensorimotor
deprecap: lung cancer screening programme by ldct for patients with copd or emphysema.

Conditions: Lung Cancer; COPD; Emphysema

Summary: the deprecap (early detection of lung cancer) study is an ongoing, prospective, longitudinal, multicenter lung cancer screening program that recruited individuals with copd or emphysema from the pulmonary clinics of fundación jiménez díaz university hospital and villalba general hospital, in madrid, spain. the aim of this observational study is to determine the scientific evidence needed to study the benefit and potential effects of lung cancer screening in this group of patients and to determine the long-term effects of the intervention in reducing the high mortality rates associated with late-stage lung cancer diagnosis in a very high-risk population, to address under-diagnosis of copd and to promote smoking cessation. this leads to the creation of a registry with clinical, radiological, functional data and biological samples for future studies in this cohort of patients to provide the scientific evidence needed to study the benefit and potential effects of screening for lung cancer and other tobacco-related pathologies diagnosed by low-dose ct (ldct)

participants who met the inclusion/exclusion criteria detailed below and agreed to participate, underwent annual ldct and pulmonary function tests until age 75 or 15 years of smoking abstinence, whichever came first. the study protocol was approved by the ethics committee of the fundación jiménez díaz (er2_eo180-19_fjd-hgv) and all participants signed their informed consent. inclusion criteria were males or females, 55-75 years of age, current or former smokers (less than 15 years of abstinence) with a cumulative smoking exposure of greather than 30 pack-years and a diagnosis of copd according to the gold guidelines and/or emphysema identified by ldct. individuals with a recent history of cancer (except non-melanoma skin cancer or carcinoma in situ) as well as those with other medical conditions that posed a significant risk of death were excluded.

Eligibility criteria:
inclusion criteria: * current or former smokers (\>15 years of abstinence) with a cumulative smoking exposure of \> 30 pack-years * diagnosis of copd according to the gold guidelines and/or emphysema identified by ldct and/or a carbon monoxide diffusing capacity (dlco) lower than 80% of predicted (as per the global lung function initiative (gli) equations) exclusion criteria: * individuals with a recent history of cancer (except non-melanoma skin cancer or carcinoma in situ) as well as those with other medical conditions that posed a significant risk of death were excluded from the study.

Keywords: lung cancer screening low-dose computed ct copd emphysema
a novel combinatory approach to maximize functional recovery of learning and memory in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (nlm) in persons with multiple sclerosis (pwms) and mobility disability.

the proposed research study will be the first to apply the kessler foundation modified story memory technique (kf-msmt®), the practice standard for cognitive rehabilitation, with one of two exercise programs. alone, kf-msmt® has been beneficial to nlm impairment, however, its effects are highly selective to list learning and as such, will not maximally restore nlm function. the combination of kf-msmt® and exercise provides a robust approach towards maximal functional recovery.

Eligibility criteria:
inclusion criteria: * be within the ages of 18 and 70 years of age * speak english as their primary language * confirmed ms diagnosis by a neurologist * be relapse and steroid-free for at least 30 days * mild-to-moderate self-reported mobility disability, based on the patient determined disease steps scale (pdds) * currently physically inactive, based on the godin leisure time exercise questionnaire (glteq) * right handedness exclusion criteria: * history of neurological disorders besides ms or history of uncontrolled psychiatric disorders (ex: major depression) * have contraindications to exercise, based on the physical activity readiness questionnaire (par-q) * currently use medications that may impact cognition (ex: steroids, benzodiazepines) * currently pregnant * contraindication for mri (metal or electronic devices in the body that are not considered mri safe) * severe cognitive impairment as measured by the modified telephone interview of cognitive status (tics-m)

Keywords: multiple sclerosis aerobic exercise virtual reality leg cycling mobility disability
evaluation of imaging of peripheral arteries by optical coherence tomography and intravascular ultrasound imaging

Conditions: Peripheral Artery Disease

Summary: a non inferiority trial to determine the capability of optical coherence tomography (oct) imaging to show vessel morphology in comparison to imaging provided by intravascular ultrasound imaging (ivus).

patients requiring diagnostic imaging of peripheral vessels to determine vessel condition and planning treatment strategy will have vessel segments imaged by both oct and ivus imaging catheters. the images will be collected into a library and independent readers will rank each image on the quality of vessel morphology and disease.

Eligibility criteria:
inclusion criteria: * adult * suspected vascular disease that might be a candidate for ivus * reference vessel can accommodate imaging catheters * successful diagnostic imaging and removal of ivus catheter with no adverse events exclusion criteria: * if female, pregnant or breast-feeding * unwilling to give informed consent
integrated care and lower extremity strength training among community-dwelling frail older adults in taiwan

Conditions: Frailty

Summary: objective: to determine the differential effectiveness of integrated care (ic) and lower extremity strength training (lest) among community-dwelling frail older adults in taiwan. method: the investigators randomize participants at bei-hu site from the "intervention study of geriatric frailty, osteoporosis, and depression in a community based randomized trial" into 12 weeks of either ic or lest. outcome assessments are performed at baseline, 12 weeks and 6 months after initiation of the interventions. interventions: 1. ic: participants visit the study site with health education, social activities, warm up, stretch, and low intensity resistance exercise for about 1 hour per week. if any medical problems or functional decline suspected during the visit, the case manager refers participants to their primary care physicians for further managements. 2. lest: participants receive 2 sessions of 30-minute lower extremity strength straining using isotonic strength training machines each week. the intensity is set at 60-80% of 1 repetition maximum (rm). evaluation of the exercise protocol are repeated every 2 weeks for individualized adjustments


Eligibility criteria:
inclusion criteria: * canadian study of health and aging clinical frailty scale (csha- cfs) chinese in-person interview version score is 3-6 * frailty index ≧ 1 (cardiovascular health study phenotypical classification)。 exclusion criteria: * age ≧ 80 years * live in the nursing home. * can not speak chinese,taiwanese. * communication or hearing disorders affect daily activities. * visual impairment or daily activities affect communication. * another reason can not communication or finish canadian study of health and aging clinical frailty scale (csha- cfs) chinese in-person version * study of health and aging clinical frailty scale (csha- cfs) chinese in-person interview \[9, 10\]version score is 0-2 and 7. * communication or cognitive impairments affect daily activities(exclusion 3-item recall score is \<=1) * can not stand to walk (available walkers) 5 meters, or unsteady gait when walking five meters, it looks fast fall * there is serious risk of suicide (defined as: suicide risk assessment score\> = 6 points) * alcoholism (defined as: the problem of alcoholism chinese people self-administered screening questionnaire cage have two questions (including) above answer is "yes" * long-term epilepsy, brain tumor, brain surgery, schizophrenia or bipolar disorder

Keywords: frailty exercise intervention
extracorporeal focused shock wave therapy for primary knee osteoarthritis

Conditions: Unilateral Primary Osteoarthritis of Knee

Summary: the purpose of this study is to determine whether extracorporeal focused shock wave therapy reduces knee pain and enhance function in patients with primary knee osteoarthritis.

this study is a placebo controlled randomized clinical trial (rct) in which the primary outcome is to determine whether extracorporeal focused shock wave therapy (eswt) reduces knee pain comparing the vas at baseline and one month after the end of the treatment. function assessment and progression of pain along the treatment are the secondary outcomes. function will be assessed with the western ontario \& mcmaster universities osteoarthritis index (womac), the lequesne's algofunctional questionnaire for osteoarthritis of knee (lequesne) and the timed up and go (tug). the eswt applications will be performed once a week for four consecutive weeks, the patients will be assessed for pain and function before the beginning of the treatment and one week after every application of the eswt. the treatment groups will be randomized. the allocation of the patients is sealed and will not be disclosed to the patients nor to the evaluators.

Eligibility criteria:
inclusion criteria: * clinical and radiologic diagnosis of primary knee osteoarthritis (kellgren \& lawrence i, ii or iii); * capability to understand the informed consent form; * chronic pain for at least 3 months prior to inclusion, measured by vas. (vas 4 or above); * absence of skin injures, infections or tumor in the target knee; * availability to comply with the visits. exclusion criteria: * history of spinal cord stenosis or clinical symptoms of lumbar radiculopathy; * history or onset neurological diseases; * generalized pain or fibromyalgia; * inability to walk; * history of knee surgery in the target knee; * secondary causes of osteoarthritis; * use of statins and quinolones in the previous year; * uncontrolled and ongoing psychiatric diseases; * invasive knee treatments with hyaluronic acid infusion, corticosteroids and anaesthetics, in the target knee, up to 6 months previous to study inclusion.
ipsilateral liver lobe devascularization of the large hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: assessment of short-term outcomes of ipsilateral lobe arterial devascularization of the large hepatocellular carcinoma: single center non-randomized trial.

assessment of the 30-day mortality and major complications as well as the tumor size changes of the patients undergoing ipsilateral lobe arterial devascularization of the large hepatocellular carcinoma. this is a prospective non randomized trial carried out at the ribat university hospital between april 2017 to march 2018.

Eligibility criteria:
inclusion criteria: * review and sign informed consent; * between 15 and 80 years of age at time of trial enrollment; * documented pathological and/or radiological diagnosis of hepatocellular carcinoma; * radiologically documented tumor size of \> 5 centimeters; * radiologically documented liver cirrhosis. exclusion criteria: * american anesthesia association (asa) class iv or v and/or any contraindications to general anesthesia; * uncontrollable ascites; * deep persistent jaundice; * hepatic encephalopathy; * coagulopathy; * severe thrombocytopenia; * unable or unwilling to attend follow up visits and examinations; * other associated surgical procedure;

Keywords: hepatocellular carcinoma devascularization
12-month study of amg 073 in renal osteodystrophy

Conditions: Renal Osteodystrophy

Summary: 4 doses of amg 073 or placebo over 52 weeks after a 30-day screening period. throughout the study, labs will be drawn to measure analytes such as ipth and corrected calcium. in addition, a bone biopsy will be performed at screening and at the end of study.


Eligibility criteria:
inclusion criteria: * 18 years of age of greater * using effective contraceptive measures * ipth greater than or equal to 300 pg/ml * serum calcium greater than or equal to 8.4 mg/dl; hemoglobin greater than 9 * stable hemodialysis for 1 month prior to day 1 exclusion criteria: * any unstable medical condition * pregnant or nursing women recent parathyroidectomy * change in vitamin d therapy * recent mi, seizure, malignancy, gi disorder * inability to swallow tablets
ucsf college health study on contraceptive training and education at community colleges

Conditions: Contraception

Summary: the purpose of this study is to measure whether a training and education intervention for clinic staff and young women aged 18-25 on contraceptive methods, including intrauterine devices (iuds) and the implant, will result in greater contraceptive knowledge and access among students in community colleges.

in the us, young women aged 18-25 years have limited knowledge of contraception or pregnancy risks and often experience challenges in accessing reproductive health care. they have little familiarity with the full range of contraceptives, particularly long-acting reversible contraception (larc) including the iud and implant. this campus-level, multiple component intervention provides evidence-based contraceptive training and education to clinic staff and students in this age group attending community colleges in california and texas.

Eligibility criteria:
inclusion criteria: this study involves two groups of human subjects: students at 28 community colleges and staff at the student health center and referral clinics. students must be: * female; * age 18-25; * speaks english; * sexually active (vaginal sex with a male partner) in the last year; * not currently pregnant; * does not want to become pregnant in the next 12 months; * at risk of pregnancy (including not sterilized); * enrolled in the current term at the participating community college; * first-time college students, meaning no college enrollment prior to the current academic year; and * willing to be contacted by email and telephone over the next 12 months. clinic staff must: * be employed by a participating clinic; and * offer clinical care, counseling or education for contraception at the clinic. for colleges to be eligible to be study sites, they must: * be an accredited community college; * not share health center staff with a participating college site; * have no active larc intervention; and * enroll students ages 18-25 years. exclusion criteria: * students and clinic staff will be excluded if they do not meet the inclusion criteria.

Keywords: contraception hormonal contraception long-acting reversible contraception condoms emergency contraception family planning services
developing a model to better predict diabetes and/or risk of developing diabetes

Conditions: Diabetes Type 2; Diabetes; Pre-diabetes

Summary: participants who were previously viome costumers who signed informed consent to participate and self reported type 2 diabetes or pre-diabetes were enrolled. they provided stool samples to viome and were provided with precision diet and supplement recommendations. the information obtained from this study is used to train a model to predict diabetes and/or risks of developing diabetes.


Eligibility criteria:
inclusion criteria: * viome customer * gi test collected at home using viome test kit * us citizen * 18+ years old * is not participating in any other viome study * must have answered the following on-boarding question with the indicated answer: "do you or did you ever have diabetes or prediabetes?" * signed and dated informed consent prior to any trial-specific procedures are performed * able to speak and read english * willing and able to follow the trial instructions exclusion criteria: * unable/unwilling to complete the informed consent form and the questionnaires

Keywords: viome diabetes type 2 diabetes pre-diabetes vpnp nutrition supplements precision