Kornimate/medical-research-clean huggingface dataset:
promoting sleep to prevent substance use in adolescence

Conditions: Sleep; Substance Use

Summary: the goal is to adapt and refine an innovative, developmentally-appropriate universal health promotion intervention to reduce insufficient sleep among adolescents aged 14 to 16, while engaging teens in the adaptation process to maximize the relevance, appeal, and effectiveness of the program for diverse school settings.

the goal is to adapt and refine an innovative, developmentally-appropriate universal health promotion intervention to reduce insufficient sleep among adolescents aged 14 to 16, while engaging teens in the adaptation process to maximize the relevance, appeal, and effectiveness of the program for diverse school settings. the investigators aim to conduct a pilot feasibility randomized controlled trial (rct) among adolescents (n = 300) who will be randomized to sleep fitness (sf) or sleep education (se) to obtain effect size estimates in preparation for a larger scale intervention study. this pilot trial is designed to obtain preliminary data for the following hypotheses: sf, compared to se, will produce greater pre-post improvement in sleep after treatment and at 6 month follow-up (with the possibility of a 12 month follow-up for a subset of participants, depending on resources). sf, compared to se, will produce greater pre-post reductions in substance use after treatment and at 6 month follow-up (with the possibility of a 12 month follow-up for a subset of participants, depending on resources). sf, compared to se, will produce greater pre-post improvement on selected mental health outcomes (anxiety, depression) after treatment and at 6 month follow-up (with the possibility of a 12 month follow-up for a subset of participants, depending on resources).

Eligibility criteria:
inclusion and exclusion criteria are considered at the level of schools, classes, and students. inclusion criteria: * schools: only general education high schools, not "newcomer" schools that target immigrants with limited english ability. our rationale is that we need students to read and understand english well enough to complete our study measures and understand the intervention. * classes: after the selection of schools, we will select classes that are representative of the school, insofar as they do not reflect advanced placement or remedial classes and utilize similar criteria for admission to the classes (e.g. health, advisory) so that we minimize differences between the classes in the study. * students: all participants must receive parental consent, provide their own consent, and must have sufficient english language ability exclusion criteria: * we propose no exclusion criteria for students who receive parental consent, provide their own assent, and have sufficient english language ability.

Keywords: sleep substance use adolescents
phase 3 efficacy and safety study of vvz-149 injections for postoperative pain following bunionectomy

Conditions: Pain, Postoperative

Summary: the purpose of this phase 3 study is to evaluate the efficacy and safety of an analgesic drug candidate, vvz-149 injections for treating post-operative pain following bunionectomy.


Eligibility criteria:
inclusion criteria: * men and women must be at least 18 years of age. female subjects must meet additional criteria in relation to childbearing potential. * subjects must be undergoing a planned first metatarsal bunionectomy with osteotomy and internal fixation (austin bunionectomy) without collateral procedures. * subjects must have the ability to provide written informed consent. * subjects must have the ability to understand study procedures and communicate clearly with the investigator and staff. key exclusion criteria: * subjects undergoing emergency or unplanned surgery. * subjects who had any previous bunionectomy procedure on either foot. * subjects with pre-existing conditions (other than bunion) causing preoperative pain at the site of surgery. * female subjects who are pregnant or breastfeeding. * diagnosis of chronic pain and ongoing or frequent use of pain medications.
early detection of myocardial work impairment in obesity ii(early-myo-obesity-ii)

Conditions: Overweight and Obesity

Summary: this prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.

obesity significantly increases the risk for heart failure. early detection of preclinical cardiac dysfunction in overweight or obesity and understanding its association with insulin resistance are of great importance.recently, a novel technique for myocardial work (mw) assessment has been introduced to evaluate myocardial performance. to date, change of mw has been described in several cardiac conditions including dilated cardiomyopathy, significant coronary arterial diseases, and hypertrophic cardiomyopathy, which implies regional or global myocardial dysfunction. in this study, we aimed to explore the alteration of mw in overweight or obese adults and to determine whether insulin resistance or other clinical risk factors may impact myocardial mechanics before impairment of systolic function.

Eligibility criteria:
inclusion criteria: * all patients were older than 18 without any cardiac symptoms. * the diagnosis of overweight was established when body mass index (bmi) of 25 to 30 kg/m2. * obese was defined as a bmi of 30 kg/m2 or higher. exclusion criteria: * diagnosis of type 2-diabetes mellitus according to the american diabetes association criteria; * left ventricular ejection fraction\<50% on echocardiography; * arrythmia on electrocardiogram; * severe valvular stenosis or regurgitation; * history of coronary disease (defined as stenosis\>50%) or myocardial infarction; * stress induced wall motion abnormality on echocardiography, coronary artery stenosis \>50% on coronary ct or angiography with framingham risk score of \>10; * pacemaker or defibrillator implantation; * the presence of bundle branch block; * severe infection or renal dysfunction with an estimated glomerular filtration rate \< 60 ml/min/1.73 m2); * inadequate image quality on echocardiography.
screening study for the department of rehabilitation medicine

Conditions: Convalescence; Healthy

Summary: the primary function of the department of rehabilitation medicine (rmd) is to diagnose and treat patients at the nih who have problems in locomotion, activities of daily living, occupational roles, communication, swallowing, or problems with chronic pain. the major goal of this department s to help patients achieve maximal function so that they can resume their daily living activities as normal as possible. in order for the department to accomplish it's goal it requires the involvement of medical staff and the use of a variety of tests and instruments. before a new test, evaluation technique, or piece of physical equipment can be considered for use in the treatment of patients it must be carefully studied. researchers must make sure the test, technique, or instrument is safe, sensitive, accurate, specific, and reproducible. therefore all of these tests, techniques, and instruments must first undergo a trial period. normal volunteers and patients from the rmd and outside of the rmd may be selected to participate in the trial period. this study provides a framework for researchers in the department of rehabilitation medicine (rmd) to develop new tests, techniques, technology, and equipment.

this protocol provides a framework for clinicians in the department of rehabilitation medicine (rmd) to develop and pilot new tests, techniques, technology, or equipment to remain state-of-the-art.

Eligibility criteria:
* inclusion criteria: in- and outpatients referred to the rehabilitation medicine department. normal volunteers of either sex.

Keywords: rehabilitation functional level activity of daily living mobility normal volunteer
targeted noninvasive brain stimulation to improve hand dexterity in stroke patients

Conditions: Stroke

Summary: this study will investigate the use of high-definition transcranial direct current stimulation (hd-tdcs) in the functional improvement of hand dexterity while performing music-assisted hand exercises.

stroke is a serious medical and health problem in the us, and most of the stroke patients suffer from upper-limb motor deficits including weakened hand dexterity. as upper-limb motor functions are crucial for most of the daily living activities, there is a need for effective intervention. the current therapeutic approaches involve intensive physical therapy training involving repetitive tasks which causes fatigue and lack of engagement in the patients. to address this issue, the investigators will investigate the combined use of individually targeted noninvasive brain stimulation (t-nibs) using high-definition transcranial direct current stimulation (hd-tdcs) and music-assisted hand exercises using musicglove to modulate the neuroplasticity in the desired manner to observe functional changes in hand dexterity.

Eligibility criteria:
inclusion criteria: * aged between 18-75 years * clinically diagnosed with hemiparetic stroke (weakness on one side - either left or right side of the body) * have had a stroke for more than 6 months * have weakness in moving the fingers of the affected hand * able to understand and perform the instructions that are part of the tdcs-musicglove testing and intervention. * willing and able to participate in and travel to kessler foundation for the screening session, mri session, and tdcs-musicglove sessions. * able to sit and be active for 1.5 hours during the session without cardiac, respiratory and/or pain disturbances as assessed during the screening visit. * able to provide informed consent. * medically stable and not planning for a major change in medications for at least 4 weeks exclusion criteria: * unable to move the hand because of muscle stiffness (scoring 3 or more on the ashworth scale) * have lost the sensation of hand movement * have a history of alcohol abuse and/or illicit drug use * have a history of smoking within the past 5 years * have a problem with the eyesight that would make it difficult to notice the changing instructions on a computer screen * currently enrolled in another research study that might affect this research study * a history of epilepsy (including family members who are diagnosed with epilepsy) * an active history of migraine or chronic headache * a history of mental illness (e.g. schizophrenia, anxiety, depression, and ptsd) * past or current history of treated ringing in the ears known as tinnitus or severe hearing problems * have a tattoo with metal-based ink in the head or neck. * have severe skin damage on the scalp * afraid of confined spaces (claustrophobic) * have metallic implants, including intracranial electrodes, surgical clips, shrapnel or a pacemaker. * currently taking medications that increase the risk of seizures * pregnant

Keywords: stroke hd-tdcs musicglove upper-limb rehab
growth of airways and lung tissues in premature and healthy infants

Conditions: Infant, Premature, Diseases; Bronchopulmonary Dysplasia; Asthma

Summary: the purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.

specific aim # 1: determine the relationship between parenchymal tissue and alveolar volume with normal lung growth early in life we hypothesize that during the first two years of life that parenchymal surface area and alveolar volume increase with somatic growth; however, the ratio of surface area to volume remains constant, while ventilation within the lung becomes more homogenous. specific aim # 2: determine the pulmonary sequelae of premature birth and assess the effectiveness of early treatment strategies upon the pulmonary sequelae. we hypothesize that premature birth impedes growth and development of the lung parenchyma and the airways at a corrected-age of 1-year. in addition, initiating continuous positive airway pressure (cpap) and a permissive ventilatory strategy in very premature infants at birth will improve lung growth and lung function compared to treatment with early surfactant and conventional ventilation.

Eligibility criteria:
inclusion criteria: * group 1 * full term greater than 37 weeks * group 3 * infants born premature between 23-35 weeks of age to be tested between the ages of two to twenty four months corrected. exclusion criteria: * heart disease * severe developmental delays

Keywords: infant, premature bronchopulmonary dysplasia asthma
evaluation of a toolkit to improve cardiovascular disease screening and treatment for people with type 2 diabetes

Conditions: Diabetes Mellitus; Cardiovascular Disease

Summary: diabetes is a common and serious chronic disease. however, there is a large gap between the level of care that people should receive (based on research and guidelines) and the level of care they actually receive. with the release of their 2008 clinical practice guidelines, the canadian diabetes association has a strategy to improve heart disease screening and treatment for people with diabetes. this study will evaluate whether the strategy works. the focus of the strategy was to give all family physicians in canada a toolkit in june 2009 to help them delivery better care for their diabetic patients. in ontario, only half of doctors received this toolkit. we will compare the quality of care received by diabetic patients whose doctors received this toolkit versus those who doctors did not.

a cardiovascular disease toolkit was developed by the canadian diabetes association and mailed to family physician with the spring/summer 2009 edition of the newsletter, canadian diabetes. the toolkit was packaged in a brightly-coloured box with canadian diabetes association branding, and contained: 1) an introductory letter from the chair of the practice guidelines' dissemination and implementation committee; 2) an eight page summary of selected sections of the practice guidelines targeted towards primary care physicians; 3) a four page synopsis of the key guideline elements pertaining to cardiovascular disease risk; 4) a small double-sided laminated card with a simplified algorithm for cardiovascular risk assessment, vascular protection strategies and screening for cardiovascular disease; and 5) a pad of tear-off sheets for patients with a cardiovascular risk self-assessment tool and a list of recommended risk reduction strategies.

Eligibility criteria:
inclusion criteria: * patient with diagnosed diabetes * seen in the office of a participating family physician at least once between july 2009 and april 2010 * at high risk for cardiovascular events: * previous cardiovascular disease (including ami, angina, stroke, tia, claudication); or * men aged \>= 45 years, women aged \>= 50 years; or * men aged \< 45 years, women aged \< 50 years with at least one of the following: 1. macrovascular disease (silent myocardial infarction, or evidence of peripheral arterial, carotid or cerebrovascular disease) 2. microvascular disease (nephropathy or retinopathy) 3. family history of premature coronary or cerebrovascular disease in a first-degree relative 4. duration of diabetes \> 15 years with age \> 30 years

Keywords: pragmatic randomized controlled trial cardiovascular risk reduction knowledge translation clinical practice guidelines
the importance of blastocyst diamater and its correlation to reproductive outcomes in pgt-a cases

Conditions: Infertility

Summary: morphometric measurement of blastocyst diameter was taken on the day of trophoectoderm biopsy. pgt-a was done using ngs platform, followed by thawing and transfer of euploid blastocyts. follow up of the pregnancy and implantation rates is done and recorded to study the correlation between the diameter and reproductive outcomes of the blastocyst.

blastocyst morphological grading proposed by gardner and schoolcraft including the expansion degree, inner cell mass, and trophoectoderm assessment has proved its importance. blastocyst expansion degree that can presented in diameter is linked to the blastocyst implantation and overall success. in order to evaluate the importance of blastocyst diameter in pgt-a cases, measurements will be taken on the day of trophoectoderm biopsy te (diameter in μm), followed by te biopsy using flicking technique. next, pgt-a will be done using ngs platform and results will be confirmed using pgt-ai. thawing of euploid blastocyst will take place and expansion degree, survival rate will be recorded. patient will be followed up for the clinical pregnancy and implantation rates.

Eligibility criteria:
inclusion criteria: * female aged 18-45 years old * male aged 18-60 years old * icsi cases having pgt-a for their blastocysts * must have their blastocysts cultured in time lapse incubator exclusion criteria: * presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection * any contradictions to undergoing in vitro fertilization or gonadotropin stimulation * use of donor oocytes or sperm * use of gestational carrier

Keywords: blastocyst diameter pgt-a time lapse blastocyst survival te biopsy
radiation therapy and cisplatin in treating patients with advanced head and neck cancer

Conditions: Head and Neck Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining chemotherapy with radiation therapy may kill more tumor cells. purpose: phase ii trial to study the effectiveness of radiation therapy and cisplatin in treating patients who have advanced head and neck cancer.

objectives: i. determine the rate of local regional recurrence at one year in patients with advanced head and neck cancer treated with boost radiotherapy and cisplatin. ii. determine the feasibility of treatment delivery, patient tolerance, and acute and late toxicities in these patients on this regimen. iii. determine the overall survival, disease free survival, and distant relapse rates of these patients on this regimen. outline: patients receive fractionated radiotherapy 1-2 times daily over 5 consecutive days for 6 weeks, and cisplatin iv over 1-2 hours on days 1 and 22. patients may undergo salvage surgery if biopsy proven cancer remains more than 3 months after treatment. patients are followed every 3 months for 2 years, every 6 months for 3 years, then annually until death. projected accrual: a total of 50-56 patients will be accrued for this study within 7 months.

Eligibility criteria:
disease characteristics: histologically proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx stage iii or iv no distant metastases patient characteristics: age: not specified performance status: zubrod 0-1 life expectancy: at least 6 months hematopoietic: absolute granulocyte count at least 2,000/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.5 mg/dl sgot or sgpt no greater than 2 times upper limit of normal renal: creatinine no greater than 1.5 mg/dl creatinine clearance at least 50 ml/min calcium normal cardiovascular: no symptomatic coronary artery disease no angina no myocardial infarction within the past 6 months other: not pregnant or nursing fertile patients must use effective contraception no other malignancy within the past 3 years except nonmelanomatous skin cancer prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior chemotherapy endocrine therapy: not specified radiotherapy: no prior radiotherapy to the head and neck surgery: no initial surgery (except diagnostic biopsy of the primary site or neck)

Keywords: stage iii squamous cell carcinoma of the lip and oral cavity stage iv squamous cell carcinoma of the lip and oral cavity stage iii squamous cell carcinoma of the oropharynx stage iv squamous cell carcinoma of the oropharynx stage iii squamous cell carcinoma of the hypopharynx stage iv squamous cell carcinoma of the hypopharynx stage iii squamous cell carcinoma of the larynx stage iv squamous cell carcinoma of the larynx
the change of the tetanus antibody titer after single injection of td and simultaneous injection of tig with td

Conditions: Tetanus

Summary: the investigators want to determine whether tig influences the formation of tetanus antibody after simultaneous tetanus vaccination according to age and the time-interval of the last tetanus vaccination.

when an injured patient visits the ed, unnecessary injection of tetanus immunoglobulin (tig) may cause side effects and also increase the medical expense.5 further, the opportunity of assessing a rising tetanus antibody titer may be missed after simultaneous injection of tetanus-diphtheria vaccine (td) and tig. according to age, the elevation of the tetanus antibody titer after tetanus prophylaxis might be not equivalent because of different levels of basal immunity and the time-interval of the last tetanus vaccination. therefore, we wanted to determine whether tig influences the formation of tetanus antibody after simultaneous tetanus vaccination according to age and the time-interval of the last tetanus vaccination.

Eligibility criteria:
inclusion criteria: * healthy adult volunteers exclusion criteria: * immunocompromised * febrile * allergy to the vaccine constituents * previous tetanus immunization within 5 years * medical and non-medical employees
pyrotinib plus trastuzumab and chemotherapy in her2+ metastatic breast cancer patients

Conditions: Breast Cancer

Summary: to evaluate the patterns and treatment outcomes of pyrotinib plus trastuzumab and chemotherapy in the real world.


Eligibility criteria:
inclusion criteria: * woman, age \> 18 years old * diagnosed with her2 +metastatic breast cancer * received pyrotinib plus trastuzumab and chemotherapy for at least one cycle, starting from 2018.07-2022.09 * available medical history exclusion criteria: * medical history was incomplete

Keywords: pyrotinib
ala-induced ppix fluorescence during brain tumor resection

Conditions: Brain Tumors

Summary: removing a tumor from a patients brain is hard to do because, very often, brain tumors do not have boundaries that are easy for the patients surgeon to find. in many cases, the surgeon can't tell exactly where the tumor begins or ends. the surgeon usually can remove most of the patient's tumor by looking at the mri images that were taken of the patient's brain before surgery. however, the surgeon does not have any good way to tell if the entire tumor has been removed or not. removing the entire tumor is very important because leaving tumor behind may allow it to grow back which could decrease the chances of survival.


Eligibility criteria:
inclusion criteria: * preoperative diagnosis of either presumed first-time low or high grade glioma, or recurrent glioma, or metastasis, or meningioma * tumor judged to be suitable for open cranial resection based on preoperative imaging studies. * patient or lar able to provide written informed consent. * no serious associated psychiatric illnesses. * age \> 21 years old. exclusion criteria: * pregnant women or women who are breast feeding * history of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis. * history of liver disease within the last 12 months. * elevated liver function levels greater than 2.5 times the normal limit from laboratory tests conducted within 30 days prior to surgery. * inability to comply with the photosensitivity precautions associated with the study. * plasma creatinine in excess of 180umol/l within 30 days prior to surgery

Keywords: fluorescence brain tumors brain metastases malignant glioma brain lesions