Kornimate/medical-research-clean huggingface dataset:
factors influencing morbi-mortality in right anterior minithoracotomy approch for aortic valve replacement

Conditions: Aortic Valve Disease

Summary: since 2009, positive experiences with right anterior minithoracotomy as an approach to aortic valve replacement are extensively practiced in our institution. the primary disease process for which patients are referred remains aortic stenosis. but more and more, we met older patients with both aortic stenosis and other cardiac pathology (coronary artery disease, other valvulopathy...). even if minimally invasive valve surgery has been demonstrated to significantly improve postoperative course (reduced blood transfusion, pain, hospital lengths of stay) and to enhance postoperative recovery, when compared with a median sternotomy, it is however important to have medical data and statistics in order to better understand the factors influencing morbi-mortality and thereby to continue this improvement.


Eligibility criteria:
inclusion criteria: * patients \> 18 y-o who underwent aortic valve replacement exclusion criteria: * none
a prospective, multi-center registry to evaluate safety and efficacy of hativ® electrocardiogram monitoring on patients with hemodialysis

Conditions: End-Stage Kidney Disease; Hemodialysis

Summary: the high mortality rate and costs of patients with end-stage renal disease (esrd) are a medical and socio-economic burden, so managing their risk factors is very important. recently, artificial intelligence (ai)-based electrocardiogram (ecg) analysis technology has made it possible to detect cardiovascular diseases using only ecgs by distinguishing minute differences in electrical currents in the heart that are difficult for humans to read, and active verification of its clinical effectiveness is in progress. in this study, using hativ®, a currently commercially available class ii medical device, ecgs are measured every day at home and before and after dialysis. additionally, ecgs are measured when chest discomfort or unusual symptoms were present, and the corresponding symptoms are monitored. it targets patients with smartphones over the age of 19 who are receiving maintenance hemodialysis for more than 3 months due to esrd and excludes those with intracardiac electrodes and devices. demographic characteristics, medications, blood tests, and echocardiography results are collected, and the results of additional questionnaires or cardiac tests are monitored for up to 3 months. during the study period, if there are any critical abnormalities or symptoms on the ecgs, the medical staff or the subject may request additional treatment. in conclusion, by measuring ecgs before and after hemodialysis, the investigators aim to obtain data on the frequency and type of arrhythmia, confirm the relationship between cardiovascular disease and dialysis intervals. the investigators will also apply an ai-based ecg analysis model to the measured ecgs to determine the association with the mortality rate. furthermore, the investigators plan to establish a basis for using ai analysis technology combined with a portable ecg device in the management of patients with esrd and conduct follow-up research to improve prognosis.


Eligibility criteria:
inclusion criteria: * patients with smartphones * patients over the age of 19 who * patients receiving maintenance hemodialysis for more than 3 months due to esrd exclusion criteria: * those with intracardiac electrodes and devices
phosphorylcholine pc-mab effects in subjects with elevated lipoprotein a

Conditions: Arterial Inflammation; Cardiovascular Diseases

Summary: inflammation and abnormal amount of lipids in the blood are key factors for the development and progression of atherosclerosis (thickening of the artery wall) and cardiovascular disease. lipoprotein (a) is a pro-inflammatory plasma lipoprotein that is believed to be a risk factor for cardiovascular diseases. vascular inflammation generates a range of effects, including endothelial dysfunction and migration of white blood cells into the vessel wall, which results in increased risk of cardiovascular events. this study is designed to assess the effects of multiple monthly intravenous infusions with the fully human antibody called pc-mab, in subjects with elevated lipoprotein (a).


Eligibility criteria:
major inclusion criterion: * lp(a) above 50 mg/dl at screening major exclusion criteria: * medical history of myocardial infarction (mi) or stroke within 12 months of screening * ongoing or paroxysmal atrial fibrillation * clinically overt heart failure * hypertension defined as ≥180/100 mmhg * diabetes mellitus * systemic autoimmune diseases requiring treatment * cancer, excluding basal cell carcinoma, within the last five years

Keywords: phosphorylcholine human monoclonal antibody lipoprotein a
translation of the self completed-leeds assessment of neuropathic symptoms and signs pain scale

Conditions: Neuropathic Pain; Chronic Pain; Nociceptive Pain

Summary: neuropathic pain, described as 'pain arising as a direct consequence of a lesion or disease on the somatosensory system', affects up to 3-9.8% of the investigators' population, but is often underdiagnosed and undertreated. as treatment is different for patients with neuropathic pain and nociceptive pain, it is important to screen for neuropathic pain. commonly employed questionnaire-based diagnostic tools in english speaking countries include the leeds assessment of neuropathic symptoms and signs pain scale (lanss) and neuropathic pain questionnaire (npq). self-completed lanss is particularly useful as it is not restricted to clinician's examination and can be applied in large-scale research. s-lanss has been successfully translated, validated and used successfully in arabic and turkish, but it has not been utilised in the chinese population. as verbal translations of the english questionnaires used at the bedside may be prone to errors in interpretation and requires medical practitioners to interpret the questions. therefore a translation and validation study is essential.


Eligibility criteria:
inclusion criteria: 1. native chinese-cantonese speaker 2. aged 18 to 80 3. presence of pain for more than 3 months 4. able to understand, read and write traditional chinese 5. able to give informed written consent 6. ability to complete the questionnaire exclusion criteria: 1. patients who require active pain treatment and / or intervention within 1 week after the initial consultation 2. voluntary withdrawal from study at any stage
quality of life in colorectal cancer survivors

Conditions: Colorectal Cancer

Summary: background: colorectal cancer (crc) and its treatment affect crc survivors' quality of life (qol), emotional distress and activities of daily living (adl). it is assumed that occupational therapy interventions based on cancer education may be a feasible approach. aim to examine the effect of using cancer education based on healthy lifestyle by occupational therapist on qol, emotional distress, adl and healthy lifestyle behaviors in crc survivors. methods participants with crc were designed as a two-group controlled trial, and a single-blind randomized controlled trial was conducted. these participants were randomly assigned to either an ot intervention or a non-intervention group (in a 1:1 ratio). those participants in the ot intervention group were given a consultation based on a crc education handbook by an occupational therapist for discharge preparation and on 1-month, 3-month follow-up clinic; the non-intervention group participants were given a crc education handbook (the same handbook) only for discharge preparation. the primary outcome was the change in qol measured using whooqol-bref. secondary outcomes were changes in emotional distress, adl and healthy lifestyle behaviors. outcomes were examined in baseline (discharge preparation), 1-month and 3-months follow-up clinic.


Eligibility criteria:
inclusion criteria: * (1) had a new diagnosis of crc and were suffering from cancer for the first time, (2) had undergone crc hospitalization (surgical) treatments, (3) were able to communicate in mandarin or taiwanese. exclusion criteria: * participants re-admitted within three months after discharge were excluded.

Keywords: quality of life occupational therapy
an investigational scan (mri with dixon based sequences) in detecting prostate cancer

Conditions: Prostate Carcinoma

Summary: this trial studies the use of magnetic resonance imaging (mri) with dixon based imaging sequences in detecting prostate cancer. mri uses radio waves and a powerful magnet linked to a computer to create detailed pictures of areas inside the body. researchers hope to learn if using a modified mri scan technique with dixon based imaging sequencing will help to produce better images of prostate cancer than the standard of care mri scan technique.

primary objectives: i. evaluate prospectively the accuracy of dixon based sequences in detection of intraprostatic tumor nodules. ii. determine the sensitivity, specificity, positive and negative predictive value of dixon based sequences in assessment of extraprostatic tumor extension and lymph node involvement. secondary objectives: i. compare the accuracy of dixon based sequences versus multiparametric diffusion weighted imaging including diffusion tensor imaging in tumor detection and extraprostatic extension. ii. compare the accuracy of dixon based sequences in detection of transition zone tumors. iii. determine the optimal scanning parameters for dixon based sequences in the imaging of prostate adenocarcinoma. outline: patients undergo mri with additional dixon based sequences with fat and water over a total of 49 minutes.

Eligibility criteria:
inclusion criteria: * biopsy proven prostate cancer patients who are scheduled to undergo prostatectomy. * patient who is scheduled to have a clinically indicated staging endorectal prostate mri exam. * patients who have signed their informed consent form to undergo the study. exclusion criteria: * known prior hormone ablation or radiation therapy (pelvic or prostate). * patients who do not want to undergo prostatectomy and prefer other therapy or surveillance. * contraindication to conventional mr imaging (e. g. metal implants, pace maker, etc.).
effects of brain stimulation during a daytime nap on memory consolidation in patients with mild cognitive impairment

Conditions: Mild Cognitive Impairment, So Stated

Summary: the beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. slow wave sleep (sws), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. this impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tsos) within the frequency range of sws in humans (0,7- 0,8 hz) during sleep, as has been demonstrated in young, healthy subjects. if patients with amnestic mild cognitive impairment (mci)- usually characterized by initial difficulties in hippocampus dependent memory functions - benefit from transcranial slow oscillatory stimulation (tsos) during sleep as well has not been studied so far. the primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tsos) during a daytime nap on declarative memory consolidation in mci patients.


Eligibility criteria:
inclusion criteria: * amnestic and amnestic plus mci-patients: 1. concern reflecting a change in cognition reported by patient or informant or clinician (i.e., historical or observed evidence of decline over time) 2. objective evidence of memory impairment; additional cognitive domains may be affected as well; 3. preservation of independence in functional abilities 4. no dementia * age: 50-90 years exclusion criteria: * untreated severe internal or psychiatric diseases * epilepsy * other severe neurological diseases eg., previous major stroke, brain tumour * dementia * contraindications to mri

Keywords: mild cognitive impairment dementia mci brain stimulation tsos tdcs sleep nap daytime sleep memory memory consolidation
naples pci registry

Conditions: Coronary Artery Disease; Percutaneous Coronary Intervention; Myocardial Ischemia; Myocardial Infarction; Acute Coronary Syndrome

Summary: the aim of the naples pci registry is to collect prospective data on baseline clinical, laboratory, and angiographic characteristics of patients undergoing pci for acute or chronic coronary artery disease. all patients receive clinical follow-up at hospital discharge and at 1-year follow-up with the objective to assess clinical outcomes, including death, cardiovascular death, myocardial infarction, stroke, stent thrombosis, target-lesion and target-vessel revascularization, contrast-induced acute kidney injury, and bleeding events.

percutaneous coronary intervention (pci) constitutes the most commonly performed therapeutic procedure in cardiovascular medicine and one on the most frequent interventions performed in medicine. since the introduction of the procedure more than 40 years ago, the safety and efficacy profile of pci has steadily improved with continuous advances in the technique, equipment, and procedural success. in the late 1980s, the advent of coronary stents favored the widespread adoption of pci in routine clinical practice by eliminating the risk of periprocedural abrupt closure related to coronary dissection and, as corollary, the need for standby emergent coronary artery bypass grafting. nowadays, about three out of four patients requiring myocardial revascularization are managed pci. the objective of this study is to evaluate, within the framework of a prospective registry, the safety and efficacy of pci by considering all device iterations including stent-based as well as non-stent-based interventions. we will evaluate clinical, laboratory, angiographic data of all patients undergoing pci at the federico ii university hospital. clinical follow-up is collected during hospital stay and at 1-year after pci. all adverse events are independently adjudicated by a clinical events committee (cec).

Eligibility criteria:
inclusion criteria: 1. clinical evidence of coronary artery disease requiring pci; 2. age ≥18 years; 3. written informed consent. exclusion criteria: 1. inability to provide informed consent.

Keywords: percutaneous coronary intervention coronary artery disease
brief integrative alcohol interventions for adolescents

Conditions: Alcohol Abuse; Drug Abuse

Summary: the primary aim of this research is to test the efficacy of innovative, brief alcohol abuse prevention strategies that integrate positive youth development messages and health risk messages for adolescents in high school settings. a secondary aim is to examine these strategies in various combinations as interventions and re-interventions (i.e., boosters) for sustaining or enhancing behavior change over time. these strategies are founded upon an emerging conceptual framework titled the behavior-image model emanating from findings of our recent trials examining multiple behavior health interventions. the long-term objective of this project is to reduce alcohol abuse and problems among older high-risk adolescents for whom alcohol and drug use disparities exist, yet who are often overlooked in prevention research and services.

a total of 921 adolescents from two diverse high schools in northeast florida were randomized to receive either the: 1) in-person consult, 2) parent-youth letter, 3) adolescent newsletter, or 4) standard care control . three-month, one-year and 18-month follow-ups are planned, with interventions to be implemented in rotating fashion as re-interventions immediately after three-month and one-year data collections. plans for following year include the following: 1) collecting and analyzing 3-month post-intervention data to determine the effects of the initial consult, parent-youth and adolescent print strategies, intervention costs, and assess possible mediators and moderators of outcomes; 2) implementing the first round of re-interventions; 3) collecting and analyzing one-year post-baseline effects of re-interventions, determining costs and cost-effectiveness of the interventions/re-interventions, and assessing possible mediators and moderators of outcomes; and 4) implementing the second round of re-interventions.

Eligibility criteria:
inclusion criteria: * can read english * 10th and 11th grade high school students at participating sites exclusion criteria: * cannot read english * not in 10th and 11th grade high school students at participating sites

Keywords: brief image intervention adolescents school
efficacy and safety of bgb-290 in the treatment of metastatic her2-negative breast cancer patients with brca mutation in china

Conditions: HER2-negative Breast Cancer

Summary: this is a phase 2, open-label, multi-center study of bgb-290 administered orally (po) twice daily (bid) in adult chinese patients with advanced her2(-) breast cancer harboring germline brca mutation, which have progressed despite standard therapy, or for which no standard therapy exists.


Eligibility criteria:
inclusion criteria: 1. confirmed deleterious or suspected deleterious germline brca1 or brca2 mutation 2. locally advanced or metastatic breast cancer despite standard therapy and the following: 1. histologically or cytologically confirmed her2(-) breast cancer (tnbc or estrogen receptor-positive and/or pr+) 2. ≤ 2 prior lines of chemotherapy in advanced or metastatic setting 3. prior platinum therapy allowed as long as no disease progression while on treatment, or if given in neoadjuvant/adjuvant setting with ≥ 6 months from last platinum to relapse 4. prior therapy with an anthracycline and/or a taxane in neoadjuvant/adjuvant or metastatic setting 5. archival tumor tissues will be collected from all patients, if available 6. for hr(+)/her2(-) breast cancer only: patients must have received and progressed on at least one endocrine therapy either in adjuvant or metastatic setting, or have disease that the treating physician believes to be inappropriate for endocrine therapy 3. measurable disease as defined per recist, version 1.1 4. eastern cooperative oncology group (ecog) performance status ≤ 1 5. adequate hematologic and organ function exclusion criteria: 1. unresolved acute effects of prior therapy of ≥ grade 2 2. prior treatment with a poly\[adp-ribose\] polymerase (parp) inhibitor 3. chemotherapy, radiotherapy, biologic therapy, immunotherapy, investigational agent, anticancer chinese medicine, or anticancer herbal remedies ≤ 14 days (or ≤ 5 half lives, if applicable, whichever is shorter) prior to day 1 of cycle 1 4. major surgical procedure, open biopsy, or significant traumatic injury ≤ 14 days prior to day 1 of cycle 1, or anticipation of need for major surgical procedure during the course of the study 5. diagnosis of myelodysplastic syndrome (mds) 6. other diagnosis of malignancy 7. untreated and/or active brain metastases. 8. active infection requiring systemic treatment, active viral hepatitis, or active tuberculosis 9. clinically significant cardiovascular disease 10. pregnancy or nursing 11. known history of intolerance to the excipients of the bgb-290 capsule
impact of education during pregnancy in overweight pregnant women

Conditions: Overweight; Obesity; Pregnancy; Childhood Obesity

Summary: metabolic environment of the foetus during pregnancy in obese women is altered and the child exposed at an increased risk of obesity. rapid infancy and childhood weight gain is associated with subsequent obesity. the purpose of the study is to test the efficacy of an educational intervention during pregnancy in obese or overweight women, on the reduction of rapid infancy weight gain in the two first years of life.

in a first time, we propose to pregnant overweight women to participate a study based on the follow up of their pregnancy and of their child during the two first years of life. women in agreement with the study sign a consent form and fill in a questionnaire about their quality of live. we secondly randomized the women in two groups: group a: in this group an intervention is delivered. it provide education, at regularly scheduled sessions (20 weeks, 28 weeks, 35 weeks, and 2 month after delivering) and two dietary consulting. the sessions that stress about healthy eating and modest exercise assemble several women (no more than 10). women in agreement with this intervention sign a consent form. group b: in this group, pregnant women are managed with standard care (at least one dietary consulting is proposed around 26 weeks). risk factors for child obesity are researched by questionnaire (parents smoking habit, mother and father level of education, family history of obesity, risk factors for gestational diabetes...). mother weight measured at every clinic visit, is recorded as complications during pregnancy (hta, preeclampsia, diabetes, fetal malformation ...) and during delivery. mother glycosylated haemoglobin is measured at birth. variables of interest for the children included at birth: gestational age, sex, neonatal pathology, hospitalisations and hypoglycaemia episode. measurement, and method of infant feeding are recorded at birth, and by phone call every 2 months during 6 months, at 9 month, 1 year, 18 months and 2 years. at 4 months the mother fill in a questionnaire about the amount of milk or other foods eaten by the child. a visit is planed at 2 years for: * clinical examination of the child, * recording of his nutritional and exercise habits * questionnaire about quality of life of the mother and her health * measurement of her bmi, arterial pressure, glycaemia before and after 75 g oral glucose-tolerance test, glycosylated hemoglobin, and lipid test.

Eligibility criteria:
inclusion criteria : * pregnant women who agree the study * bmi \> 25 kg/m². bmi is based on retrospective self reported weight of the patient before pregnancy. * no more that 21 weeks of gestation. * social security exclusion criteria : * women younger than 18 yrs, * multiple gestation, * high risk pregnancy, * psychiatric pathology, * diabetes diagnosed before the inclusion * fetal malformation * history of obesity surgery * women with no understanding of french language * women planning to move to another area.

Keywords: prevention child obesity pregnancy overweight women obese women