Kornimate/medical-research-clean huggingface dataset:
the effect of mobile application used by patients

Conditions: Surgical Patient; Nursing Caries; Laparoscopic Cholecystectomy

Summary: the aim of this study is to evaluate whether a patient-centered mobile application used during the perioperative period can improve anxiety, complications, comfort, and patient satisfaction compared to standard care.

surgical intervention is a life-threatening condition. it is known that fear and anxiety experienced throughout the surgical process disrupt homeostatic balance, leading to biological, psychological, and social problems in individuals and prolonging the length of hospital stay. in surgical cases that typically require a hospital stay of one day or less, when there is insufficient time for proper education and guidance, patients may experience anxiety and difficulties. this can lead to repeated hospital visits and increased costs. effective and accurate communication between the patient and the nurse can ensure the best implementation of nursing care, help the patient feel safer, reduce anxiety, increase care satisfaction, and lower costs. complications frequently arise after hospital discharge. due to a lack of information regarding recovery expectations, many patients may feel insecure, anxious, and alone. the use of the internet for health information has significantly increased over the past decade. mobile medical applications can be a useful tool for improving perioperative patient education and care. most acute care hospitals provide discharge instructions in the form of a brochure, which is often difficult to follow. a mobile application could serve as an educational and instructional resource for patients throughout the perioperative period. it can provide real-time feedback on patients' adherence to perioperative eras elements and demonstrate their ability to aid recovery. there are very few studies investigating the ability of mobile applications to assist in the recovery of surgical patients. various studies have shown that complications, pain, anxiety, unexpected primary care visits, hospital readmissions, and rehospitalizations are primarily caused by a lack of information. the aim of this study is to evaluate whether a patient-centered mobile application used during the perioperative period can improve anxiety, complications, comfort, and patient satisfaction compared to standard care.

Eligibility criteria:
inclusion criteria: having a smartphone to install the mobile application no barriers to communication in turkish scheduled for surgery willing to participate in the study above 18 years of age sufficient ability to use the mobile application exclusion criteria: communication barriers inability to use the mobile application unwillingness to participate in the study

Keywords: laparoscopic cholecystectomy, surgical patient, nursing care
a study to evaluate the safety and efficacy of celgosivir and peginterferon alfa-2b, with or without ribavirin, in patients with chronic hepatitis c genotype 1 infection

Conditions: Hepatitis C, Chronic

Summary: the objective of the study is to evaluate the safety and efficacy of celgosivir plus peginterferon alfa-2b, with or without ribavirin, for 12 weeks in patients with chronic hepatitis c genotype 1 infection.


Eligibility criteria:
inclusion criteria: * 18-65 years of age, inclusive * primary diagnosis of chronic hcv infection * non-responders to previous pegylated interferon-based therapy exclusion criteria: * patients naive to interferon-based therapy for chronic hcv infection

Keywords: hepatitis c celgosivir hcv genotype 1 non-responders early viral response evr
comparing suicide prevention interventions to guide follow-up care: the spring trial

Conditions: Suicide; Suicide Prevention; Suicide and Self-harm

Summary: pragmatic randomized controlled trial to compare the effectiveness of two-way caring contacts text messages vs. one-way caring contacts text messages vs. enhanced usual care for suicide prevention in adults and adolescents.


Eligibility criteria:
inclusion criteria: * adolescents (12-17 years old) and adults (18+) * response of "yes" to at least one item on the columbia suicide severity rating scale (c-ssrs) six-item screener at a st. luke's health system (slhs) primary care or behavioral health clinic, or electronic health record or provider note from an eligible encounter indicates suicide risk * ability to send and receive text messages * ability to receive phone calls * ability to receive emails * participant and legal guardian (if applicable) speak, read, and understand english * accommodations may be made for individuals with impaired hearing exclusion criteria: * individuals who participated in a previous randomized controlled trial in the same health system related to caring contacts (sparc trial or mhapps trial) * patients who are unable or unwilling to provide informed consent\*, for example, due to acute or chronic cognitive impairment (i.e.: acute psychosis, intoxication, or intellectual disability). * primary care provider, behavioral health provider, or principal investigator determines that participation in the research is not in the best interest of the patient or the study team.

Keywords: caring contacts brief contact intervention adult adolescent primary care behavioral health follow-up care
an observational study of the effectiveness of adalimumab on health and disability outcomes in new zealand patients with immune-mediated inflammatory diseases (vitality)

Conditions: Crohn's Disease; Rheumatoid Arthritis; Psoriasis

Summary: for public health purposes disability is becoming increasingly important as an outcome measure. despite this, there are few data on the effectiveness of adalimumab on disability outcomes in patients with immune-mediated inflammatory diseases (imids), particularly in the phase iv setting. there are even less data available in new zealand, which did not have the opportunity to participate to a major extent in large, multinational, phase iii pivotal studies of adalimumab in imids. the world health organisation disability assessment schedule (whodas) 2.0 is a simple, validated, free and easy-to-use generic assessment instrument for health and disability. it is applicable across cultures, in all adult populations. it is a responsive measure that can show what difference a treatment makes. results from study of effect of adalimumab on whodas scores and other patient-reported outcomes (pros) of work activity and well-being will be of interest to a variety of stakeholders in the healthcare system including patients, healthcare practitioners and payers.


Eligibility criteria:
inclusion criteria: * patients with a diagnosis of rheumatoid arthritis, crohn's disease or psoriasis who have made a decision with their physician to commence treatment with adalimumab in accordance with routine medical practice and with the approved adalimumab new zealand datasheet. * patients who have been evaluated for tuberculosis risk factors/exposure for active/latent tuberculosis infection (per local requirements and according to the approved adalimumab new zealand datasheet). * adult subjects, 18-75 years old, who have voluntarily signed and dated an informed consent form prior to any study-specific procedures. exclusion criteria: * previous treatment with adalimumab. * previous treatment with any biologic. * severe infection including sepsis, active tuberculosis or opportunistic infection. * moderate to severe heart failure (new york heart association class ii/iii). * concurrent administration with anakinra. * hypersensitivity to adalimumab or its excipients. * any condition that in the opinion of the investigator would compromise the subject's well-being or ability to perform the study requirements.

Keywords: crohn disease arthritis, rheumatoid psoriasis patient outcome assessment adalimumab global health quality of life
a phase 2 study to assess the efficacy, tolerability, and safety of nktr-181 in subjects with chronic oa knee pain

Conditions: Osteoarthritis of the Knee

Summary: nktr-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including most notably, reduced cns side effects and an attenuated attractiveness as a target of abuse.


Eligibility criteria:
inclusion criteria: * willing and able to give written informed consent; * willing and able to understand the study procedures, and comply with all study procedures; * females or males, age ≥ 18 years old; * body mass index 18-39, inclusive; * in good general health; * clinical diagnosis of oa in one or both knees; * have been on a stable regimen of pain medication for the management of oa knee pain; * not experiencing adequate pain relief with their current dosing regimen; * women of childbearing potential (wcbp) must agree to use highly effective methods of birth control. male subjects must agree to use contraception. exclusion criteria: * females who are pregnant or lactating; * known history of hypersensitivity, intolerance, or allergy to opioids; * diagnosed as having any chronic pain symptom that in the investigator's opinion would interfere with the assessment of pain and other symptoms of oa; * presence of any medical condition that would preclude study participation in the opinion of the investigator; * clinically significant abnormalities of vital signs or clinical laboratory results; * clinically significant electrocardiographic abnormalities; * received systemic corticosteroids within 30 days prior to signing the consent form; * subjects who are known or suspected to be currently abusing alcohol or drugs; * positive urine drug screen, or alcohol breath test during screening period testing; * positive serology for the surface antigen of hepatitis b (hbsag) or hepatitis c (anti-hcv) during screening period testing; * known to be human immunodeficiency virus (hiv) positive; * donation of blood or plasma within 30 days prior to signing the consent form; * participation in another drug or biologic study within 30 days prior to signing the consent form; * any other reason that, in the opinion of the investigator or medical monitor, would render the subject unsuitable for participation in the study.

Keywords: nektar nktr-181
hydrogen sulfide production by oral microflora

Conditions: Oral Malodor (Halitosis)

Summary: oral malodor is a common condition. in most cases this condition results from the proteolytic activity of anaerobic oral bacteria. these bacteria produce volatile sulfide compounds which are fowl smelling and are felt during exhalation and speech. the aim of the present study is to examine a simple method of detecting these bacteria in samples taken from the oral cavity of oral malodor patients.


Eligibility criteria:
inclusion criteria: * oral malodor patients exclusion criteria: * smokers, users of antibiotic one month prior to study
gold against pains from osteoarthrosis in the knee

Conditions: Arthritis

Summary: gold implantation around arthritic joints is a very popular treatment - but the effect has never been controlled.

randomization between 1. gold (4 x 3 berlocks, injected under local anesthesia) and 2. sham operation - only local anesthesia functional and pain measures reported through the next 6 months.

Eligibility criteria:
inclusion criteria: arthrosis in knee joint exclusion criteria: need for nsaid

Keywords: arthrosis gold
early childhood obesity programming by intrauterine growth restriction

Conditions: Childhood Obesity; Epigenetics

Summary: the molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. here, the investigators address major questions about early childhood obesity programming by studying cd3+ t-cells from intrauterine growth restricted (iugr) newborns who have an increased risk for obesity and other metabolic disorders in adult life.

epidemiological studies of multiple cohorts suggest an increased risk for obesity, cardiovascular disease-related death and type 2 diabetes in low birth weight infants. however, the molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. alterations in dna methylation during fetal life have been proposed to be one of the mechanisms that regulate this phenotype. here, the investigators address major questions about early childhood obesity programming by studying purified subpopulations of cd3+ t-cells from intrauterine growth restricted (iugr) newborns who have an increased risk for obesity and other metabolic disorders in adult life. the investigators will correlate altered cd3+ t-cell dna methylation profiles in cord and peripheral blood samples and functional changes in cd3+ t-cells with adiposity in childhood.

Eligibility criteria:
inclusion criteria: * healthy singleton term iugr and aga infants whose mothers are followed by the obstetric department of montefiore medical center and who deliver at the weiler division of montefiore medical center. exclusion criteria: * multiple gestation, maternal depression, maternal renal disease, infants in extremis, apgar score \<7 at 5 min and umbilical artery ph ≤7.25, chromosomal/ congenital abnormalities, congenital infections and inborn errors of metabolism. we will also exclude infants born to mothers with a history of maternal smoking in the 2nd and 3rd trimester of pregnancy and maternal gestational diabetes/t2d.
field trial of a relapse prevention program for adolescents receiving substance use treatment

Conditions: Substance-Related Disorders

Summary: the purpose of this study is to provide a comprehensive evaluation of the new, navigating my journey program for adolescents receiving treatment in an outpatient substance abuse center. the primary hypotheses are that, relative to the control condition, navigating my journey will be associated with significantly higher motivation, higher self-efficacy, improved relapse coping skills, and lower substance use. the secondary hypotheses are that, relative to the control condition, navigating my journey will be associated with increased therapeutic alliances with counselors.

the randomized, control trial will compare clients receiving treatment in an outpatient substance abuse center in the following two conditions -- (1) experimental: navigating my journey (includes 12 core lessons and 8 supplemental lessons); and (2) attention control (treatment as usual plus online health information) -- using a longitudinal design.

Eligibility criteria:
inclusion criteria: * currently meeting with a counselor in the study at least twice per month during the next 3 months * age 13 to 21 * ability to read and speak english * have drugs and/or alcohol as their primary or secondary substance used * have completed detox as necessary * an active email account.

Keywords: online adolescent substance abuse relapse prevention program
clinical in-hospital evaluation of the usefulness of a new multi-detector computed tomography scanner from arineta ltd

Conditions: Coronary Artery Disease

Summary: clinical evaluation of a new cardiovascular oriented ct scanner from arineta ltd.

the study will evaluate a new twin source relatively compact ct scanner with advanced technology which is optimized for cardiovascular imaging. eligible patients with a clinical indication will undergo coronary or cardiac ct scans using the new spotlight ct from arineta ltd. image quality and usefulness of the new system will then be evaluated.

Eligibility criteria:
inclusion criteria: 1. symptomatic patients with a clinical indication for cardiac ct 2. patients with a clinical indication for ct 3. estimated gfr \> 60 ml/min exclusion criteria: 1. no clinical indication for ct scanning 2. contra-indication for ct scanning or for iv contrast administration 3. pregnancy 4. inability to give an informed consent

Keywords: multidetector computed tomography
study on endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy via a tunnel in the diagnosis of mediastinal lymphadenopathy

Conditions: Mediastinal Lymphadenopathy

Summary: the goal of this clinical trial is to clear the diagnostic yield and safety of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (tbmc) via a tunnel. the main questions it aims to answer are: does ebus-tbmc via a tunnel have a superior diagnostic yield to ebus-transbronchial needle aspiration (tbna)? when ebus-tbmc via a tunnel could be performed as a first-line diagnostic tool in patients with mediastinal and/or hilar lymphadenopathy? researchers will compare ebus-tbmc via a tunnel to ebus-tbna to see if ebus-tbmc via a tunnel has a superior of diagnostic yield with a well-tolerance. participants will: recieve ebus-tbmc via a tunnel and ebus-tbna in a predefined sequence. recieve chest ct examination and follow-up for 7 days after procedure.


Eligibility criteria:
inclusion criteria: * patients with at least one mediastinal and/or hilar lymphadenopathy (≥1cm in the short axis) in the absence of a known or suspected primary lung cancer, requiring diagnostic bronchoscopy. * the selected patients should complete the routine examination of ebus-tbna/ebus-tbmc via a tunnel before operation, such as blood routine examination, coagulation function, electrocardiogram, chest ct, etc. * there was no contraindication of puncture and cryobiopsy. * fully informed of the purpose and method of the study, agreed to participate in the study, and signed the informed consent form. exclusion criteria: * the lesion is a mediastinal cyst or abscess. * the patient is allergic to lidocaine and midazolam. * the site to be biopsied has a high risk of bleeding detected by doppler and/or contrast ct such as bronchial artery penetration or suspected lung metastasis of renal cancer. * unstable angina pectoris, congestive heart failure, severe bronchial asthma * the patient did not agree to participate in this study * participation in other studies within three months without withdrawal or termination will affect the observation of this study * the researcher believes that there is any person who is not suitable for the selection
beta-glucan driven vs. empirical antifungal therapy in critically ill patients

Conditions: Antifungal Agents

Summary: this study is aimed to compare the duration of standard anti fungal therapy in high risk icu patients with a strategy driven by betadglucan test result


Eligibility criteria:
inclusion criteria: * icu admission (minimum of 48 hours in icu with an expected length of stay of at least 48 hours) * ongoing mechanical ventilation * presence of cvc * sepsis/septic shock development while receiving broad spectrum antibiotics * positivity of candida score or candida colonization index in absence of septic shock exclusion criteria: * complicated candida infection * already ongoing anti fungal therapy * beta glucan test not available * absence of informed consent * immunesuppressive status (long-term immunesuppresive or steroids therapy; aids; wbc \<1000/mmc or neutrophils \<500/mmc) * pregnancy * already enrolled in other interventional studies
influence of lateral pressure on sectional matrix

Conditions: Class II Dental Caries

Summary: the aim of this study was evaluating the clinical effectiveness of the hand instrument in conjunction with sectional matrix when applying lateral forces at the contact area during curing to achieve large and tight proximal contacts in posterior teeth.

dental caries is considered as one of the most prevalent oral infections. initiation of dental caries is a mufti-factorial process, its risk factors includes high loads of cariogenic bacteria, increased frequency of sugar intake, insufficient exposure to fluoride and reduced salivary flow. other factors that may influence the occurrence of caries include poor oral hygiene and socio-economic status. inter-proximal caries lesions develop between the contacting proximal surfaces of two adjacent teeth. massive evolution took place in restorative techniques, composite resin materials, cavity designs and armamentarium in the past few decades. as well as drastic solutions for earlier problems of composite resins such as bonding to dentin, wear resistance, postoperative sensitivity and polymerization shrinkage. despite all the progress noted in that area, still achieving proximal contact tightness in class ii resin composite restorations is considered one of the biggest challenges facing clinicians proximal contact tightness is a physiological dynamic entity of multifactorial origin that is largely affected by tooth type, location, time of day, patient position, mastication and restorative procedures failure to obtain proper proximal contact area will influence stability of dental arch and transmission of forces along long axis of teeth during mastication. traumatic masticatory forces can lead to various problems like; rotation and displacement of the teeth, lifting forces on the teeth, deflective occlusal contacts and food impactions that would result in trauma, pain, inflammation and bleeding of the periodontium. the contact must be neither open nor too tight. aim of this study was evaluating the clinical effectiveness of the optra contact in conjunction with sectional matrix when applying lateral forces at the contact area during curing to achieve large and tight proximal contacts in posterior teeth.

Eligibility criteria:
inclusion criteria: * patients having posterior class ii carious lesions were included * absence of pain from the tooth to be restored * good general health * age range:18-50 years * fully erupted occluding teeth exclusion criteria: * diastema between posterior teeth * presence of fixed partial dentures * severe periodontal diseases tooth mobility non vital teeth