Kornimate/medical-research-clean huggingface dataset:
pd-1/pd-l1 inhibitors and anti-angiogenic therapy combined with/without tace/haic in patients with bclc b/c hepatocellular carcinoma beyond up-to-7

Conditions: Hepatocellular Carcinoma

Summary: this is a retrospective study that retrospectively included patients with intermediate and advanced hcc beyond up to seven who received first-line treatment with pd-1/pd-l1 inhibitors and anti-angiogenic agents combined with/without tace/haic from january 01, 2019 to december 31, 2023 in the department of hepatic oncology and department of liver cancer surgery, zhongshan hospital, fudan university.


Eligibility criteria:
inclusion criteria: * patients who have been diagnosed with advanced hepatocarcinoma (hcc), confirmed histologically or clinically. * patients with barcelona (bclc) stage b and c beyond up to seven; * have not received any prior systemic therapy for hcc (including: chemotherapy, molecular targeted therapy, immunotherapy); * receiving only post-marketing pd-1/pd-l1 inhibitors in combination with anti-angiogenic agents (including, but not limited to, drugs containing hepatocellular carcinoma indications); \*the interval between the first use of pd-1/pd-l 1 inhibitors and the use of anti-angiogenic drugs is ≤ 1 week * tace was performed within 1 month prior/after the first pd-1/pd-l 1 inhibitor/antiangiogenic drug treatment; * tace treatment followed by at least 1 cycle of combination therapy, including: ctace and deb-tace; * there is at least 1 measurable lesion in the liver according to recist v1.1 criteria exclusion criteria: * cholangiocellular carcinoma, mixed hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma, or hepatic fibrous laminar carcinoma that has been pathologically/histologically confirmed; * patients who do not meet the above definition of combination therapy; * patients had malignant tumors other than hcc within 5 years prior to enrollment (except cured limited tumors, including cervical carcinoma in situ, basal cell carcinoma of the skin, and prostate carcinoma in situ)
functional diagnostic accuracy of ultrasonic flow ratio in assessment of left main coronary artery stenosis

Conditions: Left Main Coronary Artery Disease

Summary: this is a prospective, observational, single-center study. the main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (ufr) in predicting functionally significant left main (lm) coronary stenosis with conventional pressure wire-based fractional flow reserve (ffr) as the standard reference. the study will be conducted in fuwai hospital, and a total of 120 patients with intermediated left main coronary vessel diameter stenosis ≥30% and ≤80% are planned to be recruited. participants who meet the inclusion criteria and do not meet the exclusion criteria will undergo intravascular ultrasound (ivus) followed by ffr examination. ivus imaging will be sent to an independent core laboratory for ufr calculation. ufr analyses were performed offline in a blinded fashion without awareness of ffr measurement. using ffr≤0.80 as the gold standard, the sensitivity and specificity of ufr in the functional significance of left main coronary artery stenosis will be analyzed.


Eligibility criteria:
inclusion criteria: * stable angina pectoris, unstable angina pectoris, or after the acute phase of myocardial infarction * age ≥18 years * written informed consent * intermediated left main coronary lesions (diameter stenosis of 30%-80% by visual estimation from coronary angiography) exclusion criteria: * ineligible for diagnostic ivus or ffr examination * prior coronary artery bypass grafting of the interrogated vessels * myocardial infarction within 72 h of coronary angiography * severe heart failure * serum creatinine levels \>150 umol/l, or glomerular filtration rates \<45 ml/ kg/1.73 m2 * allergy to the contrast agent or adenosine * life expectancy \< 2 years * proximal lad diffuse lesions (diameter stenosis \> 50%) * ivus pullback not covering the entire lesion * severe myocardial bridge in the interrogated vessel

Keywords: intravascular ultrasound ultrasonic flow ratio fractional flow reserve
revatio special investigation for long-term use in pediatric patients

Conditions: Pulmonary Arterial Hypertension

Summary: secondary data collection study: safety and effectiveness of revatio in pediatric patients under japanese medical practice

the objective of this study is to obtain the information on dosage and administration, safety, and efficacy of revatio when it is administered for a long period of time (1 year) under the actual use after the approval of the dosage and administration in pediatric patients (aged 1 year or older, weighed 8 kg or more) .

Eligibility criteria:
inclusion criteria: * pediatric patients aged 0 to under 15 years who were confirmed to have received revatio after the approval date of dosage and administration of revatio for pediatric patients. exclusion criteria: * none.

Keywords: revatio pulmonary arterial hypertension pediatric patients
the role of thread embedding acupuncture for pain and quality of life in endometriosis patients

Conditions: Endometriosis-related Pain

Summary: endometriosis is a common gynecological problem, with pain as the main problem. pain can be felt for years, in high intensity, continuous, unpredictable, and disrupts the patient's daily life, thereby reducing the quality of life. dienogest is a progestin-derived drug, the first line therapy for endometriosis pain. other therapy options include hormonal, non-hormonal therapy, and surgery, but they have a high risk of side effects and recurrence. in cases of endometriosis, acupuncture has an analgesic effect, modulates hormones and neurotransmitters, strengthens immune cells, and reduces inflammation, therefore improves quality of life. however, the effectiveness of thread embedding acupuncture for endometriosis pain is still rarely published. this research was conducted to determine the effectiveness of thread embedding acupuncture for pain and quality of life in endometriosis patients.

this study is a one-group pretest-posttest clinical trial. research subjects will receive a one-time thread embedding acupuncture (tea) combined with dienogest as standard therapy for 8 weeks. the outcomes assessed will be pain intensity (nrs score) and quality of life score (endometriosis health profile-30 core score) 4 and 8 weeks after receiving tea combined with standard therapy (posttest), compared with standard therapy alone (pretest).

Eligibility criteria:
inclusion criteria: 1. women aged 18-45 years. 2. subjects diagnosed with endometriosis from laparoscopy, ultrasound, or histopathology. 3. subjects experience at least one type of pain including pelvic pain, dysmenorrhoea, dyspareunia, dyschezia, or dysuria with a minimum nrs score of 4. 4. the subject has undergone endometriosis therapy with dienogest for at least 1 month but the nrs score is still ≥4. 5. subjects are willing to follow research procedures and sign the informed consent form. exclusion criteria: 1. subjects who have wounds, inflammation, infection, lumps, or eczema at the puncture site. 2. pregnant or breastfeeding women. 3. subjects with blood clotting disorders or who are taking blood thinning medication. 4. have a history of diabetes mellitus, malignancy, psychiatric disorders, keloids, allergies to stainless steel or pdo threads. 5. subjects who received surgical therapy in the last 3 months. 6. subjects who have been undergoing acupuncture therapy in the last 2 weeks or tea in the last 6 months.

Keywords: endometriosis pain ehp30 acupuncture thread embedding acupuncture
the use of stopp/start criteria for medication intervention among elderly population living in a geriatric hospital

Conditions: Adverse Drug Effects

Summary: the purpose of this study is to determine if the use of stopp/start criteria (stopp-screening tool of older persons potentially inappropriate prescriptions start-screening tool to alert doctors to right treatment)for medication intervention in elderly population living in a geriatric hospital will lower the number of falls,hospitalization,will improve functioning, quality of life and reduce financial costs.

inappropriate prescribing is common in older people and is associated with adverse drug effects,hospitalization and falls. in this trial we want to check the efficacy of the screening tools stopp/start which were developed and validated in order to reduce inappropriate prescribing. stopp comprises of 65 indicators of drug-drug, drug-disease interactions and therapeutic duplication. start incorporates 22 evidence based indicators of common prescribing omissions. we will conduct a randomized controlled trial to test the hypothesis that screening the medications of older patients living permanently in a geriatric hospital will improve their quality of life. the compliance of the doctor working in the geriatric hospital to the recommendations of the screening tools will also be checked.

Eligibility criteria:
inclusion criteria: * age over 65 * live in the geriatric hospital "givaat hashlosha" permanently. exclusion criteria: * people with a terminal illness that will not live more than a year. * people who enter the geriatric hospital for a short while (are not permanent).

Keywords: stopp screening tool start screening tool mip-medication inappropriate prescription pim-potentially inappropriate medication
evaluation of surgical techniques in cirrhotic patients with ventral hernias

Conditions: Ventral Hernias in Cirrhotic Patients

Summary: ventral hernias are defects of the anterior abdominal wall, which can be congenital or acquired including epigastric, umbilical and incisional hernia. umbilical hernias represent a common surgical problem in cirrhotic patient with ascites with 20% incidence. this work was deigned to assess outcome of different techniques of closure of ventral hernias in cirrhotic patients.

ventral hernias are defects of the anterior abdominal wall, which can be congenital or acquired including epigastric, umbilical and incisional hernia. incisional ventral hernia is a frequent complication of laparotomy that occurs in up to 11 % of surgical abdominal wounds umbilical hernia represent a common surgical problem in cirrhotic patient with ascites with 20% incidence.factors that play role in occurance of umbilical hernia in cirrhotic patient with ascites patients is chronic increased intra-abdominal pressure, recanalization of the left umbilical vein, muscle wasting and fascial weakening from nutritional deficiencies (3,4). most of interventions for umbilical herniorrhaphy in cirrhotic patients with ascites done in emergency setting due to the concept of high perioperative morbidity and mortality rates in those patients. however, this strategy leads to a high risk of life-threatening complications such as incarceration and skin rupture.

Eligibility criteria:
inclusion criteria: * all cirrhotic patients with ventral hernia exclusion criteria: * hepatic encephalopathy
effects of percussive massage treatment with theragun on post exercise delayed onset muscle soreness

Conditions: Delayed Onset Muscle Soreness

Summary: this project will be randomized control trial conducted to check the effects of percussive massage treatment with theragun on pain and muscle length on post exercise delayed onset muscle soreness (doms) of calf muscles in healthy population so that we can have best treatment option for people with delayed onset muscle soreness, duration will be of 6months,purposive sampling will be done, subject following eligibility criteria from kasrat health and fitness club, will randomly allocated in two groups, baseline assessment will be done, group a will be treated with 5 minutes of percussive massage and 5 minuties of static stretching exercises, while group b will be managed with 5 minutes of static stretching exercises only. assessment will be done via, numeric pain rating scale(nprs), short-form mcgill pain questionnaire (sf-mpq) and goniometric measurements of passive ankle dorsi flexion for calf muscle length at baseline before intervention and immediately post intervention data will be analyzed by using spss version 25

percussive therapy is a form of soft tissue manipulation the same thing that a massage therapist does during a massage, and is intended to reduce muscle soreness and increase muscle length. the aim of the current study is to determine the effects of percussive massage with theragun and static stretching exercises on muscle length and pain of calf muscles on post exercise (doms) delayed onset muscle soreness. it will be a randomized control trail, where initial screening will be done as per the inclusion criteria of healthy female gym users with minimum one week of joining time and developed post-exercise doms and ages ranged from 20 to 30 years. participants with the history of lower leg injuries, any type of neuromuscular disorder and elite level of fitness will be excluded. all the study participants will perform 15 minutes treadmill, 15 minutes stationary bicycle at day one. after 24 hours participants with positive doms will be randomly place into experimental and control groups. experimental group will be treated with 5 minutes of percussive massage and 5 minutes of static stretching exercises, while the control group will be managed with 5 minutes of static stretching exercises only. participants in both the groups will be assessed on numeric pain rating scale and short-form mcgill pain questionnaire for pain and degree of passive ankle dorsi flexion for calf muscle length at baseline before intervention and immediate 24 hours, 48 hours and 72 hours after the completion of treatment session.

Eligibility criteria:
inclusion criteria: healthy females will be included participant's age will be between of 20-30 years who develops post exercise doms after 15 minutes treadmill, 15 minutes stationary bicycle exclusion criteria: subject with history of lower extremity injuries any history type of muscular disorder elite level of fitness excluded in this study

Keywords: theragun percussion stretching exercise muscle soreness
feasibility of critical flicker frequency procedure for the diagnosis of minimal encephalopathy

Conditions: Cirrhosis

Summary: all patients eligible for tips (transjugular intrahepatic portosystemic shunt) procedure will be considered for inclusion. after written inform consent, psychometric tests in order to calculate the psychometric hepatic encephalopathy (phes) score, the gold standard for the diagnosis of minimal encephalopathy and critical flicker frequency (cff) will be performed before the tips procedure. after tips, patients will be followed during one year and the psychometric test and cff will be performed every 3 months. 30 patients will be included. the main endpoint is the success rate of cff. the secondary end points are * correlation between cff and phes score * performance of cff and phes score to predict the occurrence of overt encephalopathy after tips procedure * a sample collection during tips procedure is also performed for validation of biomarkers


Eligibility criteria:
inclusion criteria: * patients with cirrhosis in whom a tips is indicated * patients have given their informed consent te be included exclusion criteria: * minor * pregnant women * patients who cannot see the red color * refusal to participate

Keywords: cirrhosis tips (transjugular intrahepatic portosystemic shunt) encephalopathy
italian validation of the beaumont behavioural inventory (bbi)

Conditions: Amyotrophic Lateral Sclerosis

Summary: up to 50% of patients affected with amyotrophic lateral sclerosis (als) can show behavioral dysfunctions within the spectrum of frontotemporal degenerations (ftd) - namely, apathy, disinhibition, loss of sympathy/empathy, perseverative and stereotyped behaviours, dietary changes \[strong et al., 2017\]. the beaumont behavioural inventory (bbi) \[elamin et al., 2017\] is a questionnaire designed for detecting ftd-spectrum behavioural changes in als patients. the present study aims at both validating the bbi in an italian als population and determining normative cut-off values of the instrument.


Eligibility criteria:
inclusion criteria: * possible, probable or definite als according to el escorial revised criteria exclusion criteria: * any other clinically significant cardiovascular, gastrointestinal, hepatic, renal, neurological or psychiatric disorder or any other major concurrent illness that in the opinion of the investigator could interfere with the interpretation of the study results

Keywords: als; frontotemporal degeneration; behavioural changes.
predictive value of dynamic combination of bnp and ngal for the prognosis of patients with sepsis

Conditions: 28-day Mortality; Sepsis

Summary: objective: to clarify the predictive value of brain natriuretic peptide (bnp) in combination with neutrophil gelatinase associated lipocalin (ngal) for the prognosis of patients with sepsis.


Eligibility criteria:
inclusion criteria: * age ≥18 years and \<85 years; * presence of severe sepsis according to survival sepsis campaign 10; * all patients voluntarily joined this study with informed consents. exclusion criteria: * participated in other trials within 30 days before the criteria for this trial were met; * expected to die within 24 hours; * pregnant; * advanced malignancy with life expectancy \<6 months; * history of congestive heart failure; * chronic renal dysfunction (baseline creatinine \>176.8μmol/l); and * relatives were unwilling to agree to the use of full life support.

Keywords: bnp ngal sepsis mortality
crispr-edited allogeneic anti-cll-1 car-t cell therapy in patients with relapsed/refractory acute myeloid leukemia

Conditions: Acute Myeloid Leukemia, in Relapse; Acute Myeloid Leukemia Refractory

Summary: cb-012 is an allogeneic chimeric antigen receptor (car-t) cell therapy that targets c-type lectin-like molecule-1 (cll-1). this is a phase 1 study to evaluate the safety, preliminary efficacy, and pharmacokinetics, of cb-012 (the study treatment) in adults with acute myeloid leukemia (aml) that has come back after prior treatment (relapsed) or did not respond or is no longer responding to other treatment (refractory). participants must have received at least 1 but not more than 3 prior lines of treatment for aml .


Eligibility criteria:
inclusion criteria: * documented diagnosis of aml with either refractory or relapsed disease, * non-proliferative disease * no more than 3 prior lines of therapy (induction, consolidation with or without allogeneic stem cell transplant, and maintenance are considered 1 line of therapy) * no available therapy with reasonable survival benefit * eastern cooperative oncology group (ecog) performance status grade of 0 or 1 and fit for allogeneic stem cell transplant * adequate renal, hepatic, pulmonary, and cardiac function, with specific laboratory criteria * women of child-bearing potential and men with a female partner who has child-bearing potential must agree to use acceptable, effective methods of birth control. exclusion criteria: * acute promyelocytic leukemia * extra-medullary disease (emd) that is metabolically inactive by 18-fdg pet-ct * prior treatment with car-t cell therapy * allogeneic stem cell transplant within 100 days before lymphodepletion * active graft-vs-host disease requiring therapy * known active or prior history of central nervous system involvement * seropositive for or history of human immunodeficiency virus (hiv) * vaccinated with live, attenuated vaccine within 4 weeks prior to lymphodepletion * active hepatitis b or c infection * primary immunodeficiency or autoimmune disease * known life-threatening allergies, hypersensitivity, or intolerance to cb-012 or its excipients other inclusion and exclusion criteria may apply.
clinical characteristics in congenital cataract eyes

Conditions: Congenital Cataract

Summary: this study involved children with congenial cataract eyes, who underwent cataract surgeries at the eye hospital of wenzhou medical university (hangzhou, china). all medical records were reviewed for primary diagnosis. all surgeries were performed by one experienced surgeon (z.y.e) and videos were collected for reviews in details. the clinical data after the surgery were also recorded for further analysis.


Eligibility criteria:
inclusion criteria: * children with congenital cataracts who underwent cataract surgeries at the eye hospital of wenzhou medical university (hangzhou, china) exclusion criteria: * ocular trauma
intraorbital injection versus oral steroid in anterior idiopathic orbital inflammation

Conditions: Orbital Pseudotumor

Summary: a multicenter randomised double-arm clinical trial, to compare safety and efficacy of oral versus intralesional injection of steroid in a group of patients suffering from idiopathic orbital inflammation is designed. outcome measures include number of recurrences, duration of remission, and side effects.

expected to be finished in 3 years, patient enrollment includes 59 patient in each arm of the study. inclusion criteria consist of clinical and/or imaging evidence of dacryoadenitis with or without adjacent rectus muscles (superior and inferior recti) myositis. patients meeting following conditions will be excluded: 1. age \< 15 years 2. diabetes mellitus 3. collagen vascular diseases 4. vasculitides 5. biopsy of lacrimal gland denoting a specific diagnosis (i.e. the term "idiopathic" does not apply) 6. glaucoma 7. patients who have lost one eye 8. bilateral disease 9. abnormal thyroid-stimulating hormone outcome measures include number of recurrences, duration of remission, and side effects. patient allocation will be based on blocks of 4. each patient will undergo lacrimal gland biopsy and subsequently will be allocated to one arm of the study according to a predetermined randomization sequence (balanced block of four). outcome measures will be recorded in 0, 3 and 6 months after patient enrollment. patients in oral steroid group will receive 1 mg/kg/day of prednisolone, tapered in 3 months (based on a detailed table). patients in injection group will receive 1 shot of 1 ml (20 mg triamcinolone + 3 mg betamethason) into the lacrimal gland.

Eligibility criteria:
inclusion criteria: * dacryoadenitis based on clinical findings and/or imaging with and without adjacent recti muscle myositis exclusion criteria: * abnormal thyroid-stimulating hormone * systemic vasculitides * bilateral orbital inflammation * collagen vascular diseases * one seeing eye * glaucoma * diabetes mellitus