Kornimate/medical-research-clean huggingface dataset:
extracorporeal therapy on shoulder and neck pain

Conditions: Musculoskeletal Disorders

Summary: the purpose of this research was to investigate the clinical effects on the eswt treatment of shoulder and neck pain.

extracorporeal shock wave therapy (eswt) has been used to treat various musculoskeletal disorders. the beneficial effects of the eswt included pain alleviation and improvement in local blood circulation. however, few study exploring the effects of the eswt for subjects with shoulder and neck pain.

Eligibility criteria:
inclusion criteria: * non-specific shoulder and neck pain * ages between 20yr to 45yr * shoulder and neck syndrome of upper trapezius and levator scapulae more than 3 months * no using medicine such as anodyne and muscle relaxants. exclusion criteria: -

Keywords: extracorporeal shock wave therapy (eswt), neck pain
additive value of physiology coronary in clinical practice

Conditions: Microvascular Coronary Artery Disease

Summary: the important evidence of coronary microcirculation for the management of patients with coronary artery disease is only increasing. thus, in recent years, a number of studies have shown that the demonstration of coronary microvascular disease (cmvd) contributes to cardiovascular morbidity and mortality increases independently of epicardial damage. this has been shown in stable coronary artery disease with screening for cmvd when there is no significant epicardial involvement and allowing the implementation of an adapted treatment then reducing the symptoms and improving the quality of life of our patients. (1). the prognostic nature of cmvd has also been identified in stable disease after coronary angioplasty (2) but also in patients with infarcts reperfused by coronary angioplasty (3). the complete exploration of the epicardial and microvascular coronary vascularization is grouped under the name of the subspecialty: coronary physiology. thus, an internationally recognized algorithm for exploring coronary physiology has been published (4). however, this algorithm is still little followed. the principe registry aims to assess the prevalence of cmvd with the use of a standardized algorithm for exploring coronary physiology by coronary angiography in our center in current practice.


Eligibility criteria:
inclusion criteria: * male or female patients over 18 years of age * having a coronary angiography * presenting in pain or having performed a positive ischemia test * affiliated with social security * non-opposition to participation exclusion criteria: * adult patient protected by law (article l1121-8) * person deprived of liberty (article l1121-8) * pregnant woman
foot massage applied before a bronchoscopy procedure on physiological parameters and anxiety

Conditions: Physiological Parameters; Anxiety; Bronchoscopy

Summary: the goal of this randomized controlled trial is to assess the effectiveness of foot massage on physiological parameters and anxiety in patients undergoing bronchoscopy. the main questions it aims to answer are: * does foot massage applied before bronchoscopy affect physiological parameters? * does foot massage before bronchoscopy affect anxiety? patients in the intervention group received foot massage once before bronchoscopy. patients in the control group did not receive any treatment other than routine care.

after the ethics committee and institutional permissions were obtained, patients scheduled for bronchoscopy were evaluated by the researcher for eligibility. first of all, they were informed about the study. those who agreed to participate and delivered written consent were included in the sample. individuals were assigned to the intervention and control groups by using block randomization. to prevent interaction between groups, the data collection process of the control group was completed first.a personal information form, the state-trait anxiety inventory, and a vital signs monitoring form were used to collect study data. in the control group, data were collected during the first arrival of the individuals (t1), 40 minutes after t1 (t2), and following bronchoscopy (t3). no procedures were applied to the control group other than clinical protocols. after the data collection process of the study was completed, the questions of the patients in the control group were answered. the data of the intervention group were collected during the first arrival of the individuals (before the massage) (t1), 40 minutes after t1 (after the massage) (t2), and following bronchoscopy (t3). massage sessions lasted approximately 40 minutes, including 20 minutes for each foot.

Eligibility criteria:
inclusion criteria: aged ≥18 years communicate verbally be conscious no lesions on the feet or any problems that may affect the feet (diabetes, neurological disorder, etc.), no previous history of bronchoscopy no history of problems or anxiety no history of any disorder no acute pain no use of opioids or strong sedatives in the last week before recruitment to the study exclusion criteria: patients who underwent emergency bronchoscopy patients who do not want to participate in the research voluntarily

Keywords: foot massage anxiety physiological parameters bronchoscopy randomized controlled trial
phenotypic characteristics of superlean individuals including gut microbiome

Conditions: Thinness; Health Behavior

Summary: the goal of this observational study is to build on our previous work to further characterise the phenotype of superlean individuals (bmi \< 18.5) when compared to normal bmi people (bmi 21.5 to 25). this will include characterising the body composition, food intake behaviour, circulating hormone levels, genetics and characteristics of the gut microbiota. the investigators expect to recruit up to 200 healthy superlean and control volunteers respectively,

the focus of this work is to characterise the phenotype and genotype of individuals who have low bmi ( \< 18.5) but are otherwise healthy and do not have eating disorders. the investigators term this group 'superlean' individuals. the study is observational and the investigators aim to establish a healthy superlean cohort,and use the combined metagenomic and metabolomic multi-omics analysis techniques, combined with imaging and physiological measurements, to focus on the correlation between gut microbiota characteristics and metabolism in superlean population. the investigators expect to recruit up to 200 healthy superlean and control volunteers (bmi 21.5 to 25) respectively, to explore the microbiota characteristics and differences between control and healthy superlean populations by measuring the basic physical indicators and metabolic parameters. this will include analyzing the postprandial hormonal changes, appetite differences, and changes in the gut microbiome and serum metabolome in the two groups of volunteers, establishing the relationship between the gut microbiota and the metabolite and metabolic phenotypes of the body, and exploring the gut microbiota.

Eligibility criteria:
inclusion criteria: * control group (21.5≤ bmi\<25), superlean group (bmi≤18.5) * age between 25-40 years old exclusion criteria: * having metabolic diseases or eating disorders * recent weight loss due to various disease causes * being treated for weight loss * having an infectious disease * pregnant and lactating women * people with blood sickness, pathological hypo- or hypertension * people suffering from claustrophobia * no metal implants in the body * use of antibiotics, probiotics, oral laxatives, etc. within 8 weeks

Keywords: superlean metabolism microbiome body composition food intake food preference
gamma knife radiosurgery for treatment of essential tremor

Conditions: Essential Tremor

Summary: the purpose of this study is to examine effects (good and bad) of gamma knife radiosurgery for essential tremor. the gamma knife places a small lesion in the brain to suppress tremors.

this research is being done because although multiple studies evaluating gamma knife for essential tremor show good results, few studies evaluating patients prospectively have been done. prior studies have looked at patient outcomes following treatment - also known as retrospective studies. in this study, data collection will initiate before treatment, to obtain consistent baseline evaluations from all study participants undergoing the gamma knife treatment and at specific intervals following treatment.

Eligibility criteria:
inclusion criteria: * men and women age 18 years or older * diagnosis of essential tremor as confirmed from clinical history and examination by a neurologist or neurosurgeon * tremor following prior first line therapy with either propranolol or primidone * must be able to undergo mri of brain and ct of head for treatment planning * postural or intention tremor severity score of greater than or equal to 2 in one hand/arm as measured by the crst rating scale exclusion criteria: * prior ipsilateral stereotactic radiosurgical ablation of the thalamus, ipsilateral deep brain stimulation, radiofrequency ablation of a ipsilateral thalamic target, or ultrasound ablation of an ipsilateral thalamic target * prior whole brain radiation therapy * pregnancy

Keywords: benign essential tremor tremor neurologic manifestations nervous system diseases movement disorders central nervous system diseases
effect of anesthetic agents on optic nerve sheath diameter

Conditions: Uterus Myoma; Uterine Cancer

Summary: the present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.

anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. on the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases. optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.

Eligibility criteria:
inclusion criteria: * female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy exclusion criteria: * history of brain hemorrhage or brain infarction * liver disease or end stage renal disease * glaucoma or any signs of increased intraocular pressure * combined wtih other types of operation * patient refusal * weight less than 40 kg or over 100 kg
phase i/ii study of oral s-1 plus docetaxel in elderly patients with advanced gastric cancer.

Conditions: Gastric Cancer

Summary: to assess the usefulness of docetaxel plus s-1 combination chemotherapy based on the antitumor effect and survival period by performing a phase i/ii study of this combination in elderly patients with inoperable or with postoperative gastric cancer.

a multicenter open-label, single-arm, phase i/ii clinical trial is conducted on elderly patients with histological stage iv gastric cancer given docetaxel plus s-1. the usefulness of this regimens as 1st line therapy for gastric cancer was evaluated by the disease-free survival rate (dfr), overall survival rate (os), incidence and severity of adverse event.

Eligibility criteria:
inclusion criteria: 1. histological diagnosis of gastric adenocarcinoma. 2. measurable or assessable lesions(except for phase i). 3. age: 76 \~ 80 years. 4. performance status (ecog): 0 \~ 2. 5. no prior chemotherapy or only one regimen of previous chemotherapy (with a washout period \>4 weeks after the final day of the previous therapy). adjuvant chemotherapy is not defined as previous therapy. 6. no history of treatment with docetaxel or s-1. 7. no history of radiotherapy to the abdomen. 8. oral intake of s-1 is possible. 9. adequate function of major organs (bone marrow, heart, lungs, liver etc.). wbc 3,500/mm3 and 12,000/mm3. hb 10.0 g/dl. platelet count 100,000/mm3. got and gpt 2.5 times the upper limit of normal (excluding liver metastasis). t-bil 2.0mg/dl. creatinine \<1.5 mg/dl (but if it is 1.0 \~ 1.5 mg/dl, the dose of s-1 can be decreased according to the dose reduction criteria to allow registration in the trial). normal ecg (not considering clinically unimportant arrhythmias and ischemic changes). 10. predicted survival for \>3 months. 11. able to give written informed consent. exclusion criteria: 1. severe pleural effusion or ascites. 2. metastasis to the central nervous system (cns). 3. active gastrointestinal bleeding. 4. active infection. 5. diarrhea (watery stools). 6. uncontrolled ischemic heart disease. 7. serious complications (such as intestinal paralysis, intestinal obstruction, interstitial pneumonia or pulmonary fibrosis, uncontrolled diabetes mellitus, heart failure, renal failure, or hepatic failure). 8. active multiple cancer. 9. severe mental disorder. 10. pregnancy, possible pregnancy, or breast-feeding. 11. flucytosine treatment. 12. judged to be ineligible for this protocol by the attending physician.

Keywords: docetaxel s-1 elderly patients gastric cancer
preoperative nutritional status and postoperative outcomes in colorectal cancer

Conditions: Colorectal Cancer

Summary: the aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes. the study will include 120 colorectal cancer patients who are scheduled for surgical treatment.

a questionnaire form containing general information, dietary habits, and food consumption records will be applied by the researcher in the preoperative period to the patients who volunteered to participate in the study. body composition will be taken by bioelectrical impedance analysis method. hand grip strength will be taken with a digital hand dynamometer. the nutritional status of patients will be assessed using the criteria of the nutritional risk screening 2002 (nrs-2002) and the global leadership initiative on malnutrition (glim). for body composition analysis, computed tomography images, known as the gold standard, will be used in cancer patients. computed tomography images of the patients will be obtained from hospital records at l3 lumbar vertebra level. the software program imagej developed by the us national institute of health will be used to calculate the visceral fat area (cm2), subcutaneous fat area (cm2), and skeletal muscle area (cm2) from the recorded images. preoperative biochemical parameters will be obtained from hospital records. the systemic inflammatory response will be determined by the prognostic nutritional index, neutrophil lymphocyte ratio, and delta neutrophil index. the inflammatory load of the diet will be calculated using the dietary inflammatory index. the quality of life of patients will be assessed using cancer-specific scales developed by the european organisation for research and treatment of cancer (eortc) during the preoperative and postoperative periods. these scales are eortc-qlq-c30 for general quality of life and eortc-qlq-cr29 for colorectal cancer-specific quality of life.

Eligibility criteria:
inclusion criteria: * having been diagnosed with colorectal cancer and having surgical treatment planned * being 18 years of age or older exclusion criteria: * having received chemotherapy or radiotherapy * currently undergoing corticosteroid or hormone treatment. * presence of distant metastases. * presence of any malignancy other than colorectal cancer. * presence of autoimmune disease. * presence of ongoing infectious disease.

Keywords: colorectal cancer nutritional status body composition quality of life postoperative complication
consequences of human inactivity

Conditions: Inactivity; Obesity; Type 2 Diabetes

Summary: epidemiological studies as well as both longitudinal animal and human inactivity studies indicate that low physical activity is associated with the pathophysiology of type 2 diabetes mellitus (t2dm) and obesity, and recently it has been estimated that physical inactivity (worldwide) causes 7% of the burden of disease related to e.g. t2dm. physical inactivity, a high energy dietary intake, and t2dm are also associated with dementia, depression, and impaired cognitive function. it is critical that we understand how inactivity alters body composition, glucose and lipid metabolism, and cognitive function, if normal physical activity can prevent these changes, and if there are any differences between sexes. the present protocol is divided in several in several sub-studies: 1. to test whether and how a physically inactive lifestyle will influence body composition, glucose and lipid metabolism, and cognitive function. 2. to test whether normal physical activity can prevent the deleterious effect of a physically inactive lifestyle despite a high-caloric intake. 3. to test whether the influence of a physically inactive lifestyle combined with a high-caloric intake differs between sexes.


Eligibility criteria:
inclusion criteria: * normal physical active * healthy * 18-40 y of age * non-smokers exclusion criteria: * pregnancy * diabetes in family

Keywords: inactivity obesity type 2 diabetes glucose metabolism lipid metabolism cognitive function
association of processing speed dysfunction and brain functional abnormality in ects

Conditions: Epilepsy, Rolandic

Summary: epilepsy with centrotemporal spikes (ects) is the most common epilepsy syndrome in children. language impairment has been widely investigated in patients with ects, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.

objective to investigate the processing speed dysfunction in patients with ects, and the associated brain functional abnormality using functional magnetic resonance imaging (fmri) and 18f-fluorodeoxyglucose (18f-fdg) positron emission tomography (pet). design, setting, and participants this study prospectively enrolled ects patients (n = 28) from june 2019 and june 2021. twenty age- and gender- matched healthy children and another twenty children with extracranial tumors were enrolled as controls. patients with ects and healthy controls underwent neuropsychological testing and fmri examination. in addition, ects patients and children with extracranial tumors underwent 18f-fdg pet examination.

Eligibility criteria:
inclusion criteria: * (a) age between 6 and 18 years; (b) 18f-fdg pet examination more than 48 h since the last seizure, (c) no structural abnormalities associated with epilepsy detected on routine mri exclusion criteria: * (a) any history of other neurological or psychiatric disorders; (b) pre-scan plasma glucose level \> 120 mg/dl before 18f-fdg pet/ct examination;(c) any contraindications for mri examination ; (d) head movement (translation \> 3 mm or rotation \> 3 degree ) during mri examination

Keywords: processing speed epilepsy positron emission tomography functional magnetic resonance imaging
optimizing the use of morphine in pre-term neonates

Conditions: Premature Neonates

Summary: the purpose of this study is to improve the dosing of morphine in critically ill premature neonates.

the investigators hypothesize that identifying co-variates predictive of variability in morphine disposition and/or response will provide the scientific basis for rationale and individualized morphine dosing schemes in neonates and young infants. 60 preterm neonates ranging in gestational age from 22 to 32 weeks will be recruited from the nicu. stratification by gestational age will be done to ensure broad representation. the decision to initiate morphine therapy will be based solely on clinical indications. prior to morphine dosing, a biochemical assessment of hepatic and renal function will be obtained. a 0.05 mg/kg loading dose of morphine will be given by an intravenous infusion over 30-minutes in preterm neonates with a gestational age of less than 29 weeks, followed by a continuous infusion of 0.005 mg/kg/h, whereas a loading dose of 0.1 mg/kg will be given in preterm neonates with a gestational age of 29 weeks or more followed by a continuous infusion of 0.01 mg/kg/h. pain assessment will be performed at baseline (prior to study medication administration) and at .5, 1, 2, 4, 8, 12 and 24 hours after the dose. at each of these time points infants will be videotaped for two minutes with two cameras. videotapes will be scored afterward using standard validated pain assessment tools for preterm infants.

Eligibility criteria:
inclusion criteria: * preterm neonates of both genders and all races * postnatal age less than 30 days * an indwelling (peripheral or umbilical) arterial line, and * a clinical indication for intravenous morphine administration exclusion criteria: * neonates with severe asphyxia, grade iii or iv intraventricular hemorrhage, major congenital malformations/facial malformations, neurological disorders, and those receiving continuous or intermittent neuromuscular blockers. * clinical or biochemical evidence of hepatic and renal compromise (including systemic hypoperfusion) or * received drugs that are ugt2b7 substrates (including lorazepam, ibuprofen, valproic acid, naloxone and other morphine derivatives or propanolol)

Keywords: preterm neonates morphine critically ill
psychological impact of covid19 among doctors in assiut university hospitals

Conditions: Occupational Stress

Summary: study aimed to investigate the psychological impact of corona virus among doctor in assiut university hospitals, mainly stress and burn out will be assessed

prolonged exposure to stressful working environments resulting in a state of physical and emotional depletion and burnout. nowadays, while facing corona virus, health care workers are on the front line and directly assist in diagnosis, caring and treatment of patients with covid, thus keeping them at higher risk developing psychological distress and other mental health symptoms. according to previous studies, during the outbreaks of severe acute respiratory syndrome (sars) and middle east respiratory syndrome (mers), frontline medical staff had reported high levels of stress that resulted in posttraumatic stress disorder (ptsd) a lot of factors contribute to increase mental effect among healthcare workers as increasing the suspected cases and workload , depletion of personal protective equipment's , drug shortage and feeling inadequately supported . in toronto study(2008), four major risk factors for stress among medical staff during the sars outbreak were identified; including the perception of the medical of their risk of infection, the impact of sars on their work, feelings of depression, and working in high-risk medical units. moreover, there are other factors as social stigmatization and contact with infected patients, also has previously been shown to be associated with increased levels of stress and anxiety in medical staff .

Eligibility criteria:
inclusion criteria: * all doctors currently working in assiut university hospitals exclusion criteria: * no exclusion critiria