Kornimate/medical-research-clean huggingface dataset:
epigenetic regulation of exercise induced asthma

Conditions: Exercise Induced Asthma; House Dust Mite Allergy

Summary: the purpose of this study is to investigate the micro ribonucleic acid (mrna) profiles of patients with eia without allergic sensitization and eia with house dust mite sensitization compared to that of healthy controls.

patients with known eia are periodically reexamined by medical history, clinical examination, bodyplethysmography, spirometry, exhaled nitric oxide (eno), skin prick test, methacholin challenge test and exercise-challenge in a cold-chamber at 2-4°c (ecc). additionally the investigators gathers the questionnaires: asthma control test (act) and dyspnoe index (di). besides these standard procedures the investigators want to investigate the micro-rna profiles in two eia subgroups: eia with house-dust allergy (n = 24) and eia without house-dust allergy (n = 24). both groups are characterized by different eno levels. the patients with eia and house-dust allergy should have an eno \> 30 ppb, the patients with eia without house-dust allergy an eno \< 20 ppb. the micro-rna profiles of the both eia subgroups will be compared the micro rna profiles of 20 healthy controls . therefore blood will be taken (for a complete blood count and micro rna analysis) at three points of time: before ecc, directly after ecc and after 24 hours ± 4 hours after ecc.

Eligibility criteria:
for eia patients inclusion criteria: * written agreement * age \>=12 and \<= 24 * known exercise induced asthma * group 1: skin prick test positiv house-dust allergy, eno \> 30 ppb, mct pd20 \< 0,1 mg * group 2: skin prick test negative house-dust allergy, eno \< 20 ppb, mct pd20 \< 1 mg * lung function before ecc forced vital capacity (fvc) ≥ 75% and forced exspiratory pressure in one second (fev1) ≥ 70% exclusion criteria: * age \ 24 years * lung function fvc \< 75% und fev1\< 70% * inability to understand the range of the study * chronic asthma with systemic cortisone therapy * regular therapy with inhalative corticosteroids or leukotriene-antagonists \<14 days before visit 1 * intake of long acting beta-agonists (laba) 48 h before examination * intake of short acting beta-agonists (saba) 8 h before examination * acute severe infection (pneumonia) within the last 4 weeks * other chronic diseases or infections (hiv, tbc) * pregnancy for healthy controls inclusion criteria: * written agreement * age \>=18 and \<= 24 exclusion criteria: * age \ 24 years * known asthma bronchiale or other chronic lung diseases * lung function fvc \< 90% and fev1 \< 80% * allergic sensitization in skin prick test * eno \> 30 ppb * inability to understand the range of the study * acute severe infection (pneumonia) within the last 4 weeks * other chronic diseases or infections (hiv, tbc) * pregnancy

Keywords: exercise induced asthma eno exercise challenge micro rnas
flt-pet for early detection of relapse in patients with irradiated lung cancer

Conditions: Lung Cancer, Nonsmall Cell; Small Cell Lung Cancer

Summary: this study investigates the feasibility of flt-pet to improve the diagnosis of relapse in patients with irradiated lung cancer in comparison with fdg-pet/ct.


Eligibility criteria:
inclusion criteria: * history with lung cancer, small cell or non-small cell * radiotherapy of lung cancer ended within the last 24 months * radiotherapy might be normofractionated or stereotactic * current suspicion of relapse * written and oral consent exclusion criteria: * communication difficulties * pregnancy or lactation
sonographic imaging of oral and dental anatomical structures (a pilot study)

Conditions: Ultrasound; Oral Mucosa; Gingival Recession; Alveolar Bone Loss

Summary: the overall purpose of this study is to establish an ultrasound technique to aid in oral and dental examination of soft and hard tissues. ultrasound is currently not used in dentistry and associated oral examinations and its usefulness for clinical practice will be explored. this study will investigate the use of ultrasonic imaging for planning and placing dental implants, as well as evaluate the use of ultrasonic imaging for monitoring marginal bone loss around dental implants.

this study will involve two different groups of subjects: patients scheduled for a dental implant procedure, and patients scheduled for a revision surgery after developing infection after implant surgery. twenty subjects examining only specific aim one is funded and will be studied. if future funding is granted and additional 30 subjects for aim one and 40 for aim two will be studied subjects in both groups will receive an ultrasound examination of the oral cavity prior to their clinically-scheduled dental surgery. subjects in group 1 also may receive a cbct scan if not previously clinically-ordered.

Eligibility criteria:
inclusion criteria: * subjects 18 years of age and older who will be scheduled to have an implant surgery from premolar to premolar with bilateral adjacent teeth present will be recruited. exclusion criteria: * patients under 18 years of age. * unwilling or unable to read and sign this informed consent document. * do not have a tooth on each side of the implant that will be placed. * women who are pregnant or unsure of their pregnancy status.
australian multicentre colonic endoscopic mucosal resection study

Conditions: Colonic Polyps

Summary: a prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis.

a prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis. detailed data regarding lesion characteristics (size, location, paris classification, granular or non-granular surface morphology and kudo pit pattern), procedural, clinical and histological outcomes and complications are noted. multivariate analysis will be performed to identify risk factors for endoscopic mucosal resection failure and adenoma recurrence at follow-up colonoscopy.

Eligibility criteria:
inclusion criteria: * large sessile polyp (equal to or greater than 20mm) * intention to perform emr * aged 18 years or older exclusion criteria: * colonic polyps less than 20mm * aged younger then 18 years.
hyperprolactinemia and adrenal steroidogenesis

Conditions: Hyperprolactinemia

Summary: the purpose of this study is to explore the effects of prolactin on adrenal steroid profiles in patients with hyperprolactinemia due to prolactinomas before and after initialisation of treatment.

prolactin is known to influence many biological processes. one potential target is the adrenal gland, where prolactin may stimulate the production of adrenal steroid hormones. conditions of increased prolactin production(hyperprolactinemia) could, therefore, increase concentrations of adrenal steroids. one of the potential implications would be false doping accusations of athletes engaging in elite sports. this interaction between prolactin and adrenal steroidogenesis, however, remains poorly understood, and the available research findings are conflicting. the investigators, therefore, seek to explore the relationship between prolactin and adrenal steroidogenesis by monitoring prolactin levels and blood and urinary steroid profiles of patients with hyperprolactinemia due to prolactinomas before and after treatment initialisation.

Eligibility criteria:
inclusion criteria: * aged 18 years or older * female and pre-menopausal * serum prolactin \> 150 ng/ml exclusion criteria: * corticotropic and/or thyreotropic insufficiency * pregnancy, planned pregnancy or breastfeeding * physical or psychological condition likely to interfere with the normal conduct of the study and interpretation of the study results as judged by the investigator * incapacity to give informed consent

Keywords: adrenal steroidogenesis doping
evaluation of salivary elisa for hormone monitoring in donors

Conditions: Infertility, Female; Reproductive Sterility

Summary: in donors or patients undergoing assisted reproduction treatments (art) it is necessary to closely control ovarian stimulation to monitor the number and size of developing follicles. oestradiol (e2) and progesterone (p4) are products of steroidogenesis. their concentrations increase with the diameter of the growing follicle. in order to assess treatment response and support clinical decisions, accurate and reliable methods to measure e2 and p4 are essential. measurement of both hormones, as well as monitoring of follicle growth through ultrasound measurements, is an important part of ovarian stimulation, requiring patients or donors to undergo multiple blood draws. it is often a physically and emotionally painful process, and the most convenient solution is the measurement of hormones concentrations in other biological fluids, such as saliva. salivary diagnostic tests are a less invasive, inexpensive, and stress-free alternative. the current study pretends to evaluate the correlation between salivary elisa assays and serum determination of progesterone and oestradiol concentrations in oocyte donors, and, also, evaluate the feasibility of doing saliva e2 and p4 determinations in the ivirma clinic labs.


Eligibility criteria:
inclusion criteria * informed consent form dated and signed * woman undergoing cos for oocyte donation * age 18-35, inclusive * regular menstrual cycles * in good health and not suffering from any mental or medical condition(s) that would preclude participation in the study exclusion criteria • simultaneous participation in other clinical study, that at the investigator's criteria could interfere with the results of this study.

Keywords: saliva donnors oestradiol progesterone
effects of 23-gauge lensecotomy combined with anterior vitrectomy on macular in children with congenital cataract

Conditions: Macular; Congenital Cataract

Summary: congenital cataract is the main cause of form deprivation amblyopia in children. current studies confirm that form deprivation amblyopia affects the macular development. however, there are different opinions about the effect of amblyopia on the macular thickness . investigators have performed "cataract extraction with iol implantation" on children with bilateral and unilateral congenital cataract. investigators used oct biometry to measure children's the macular thickness before and after surgery..average sectional total thickness was automatically determined by the instrument's software using a modified early treatment diabetic retinopathy study (etdrs) circle grid (fovea, inner ring, and outer ring: 1 mm, 3 mm, and 6 mm. investigators dynamically observed changes in macular to explore the retinal mechanism of form deprivation amblyopia and help guide the clinical correct understanding of postoperative follow-up time.


Eligibility criteria:
inclusion criteria: * congenital cataract exclusion criteria: -incooperative to complete the preoperative and postoperative examinations.

Keywords: macular thickness
multimodal outcome characterization in comatose cardiac arrest patients registry and tissue repository

Conditions: Cardiac Arrest

Summary: cardiovascular disease remains the leading cause of death in the united states. mortality rates of cardiac arrest range from 60-85%, and approximately 80% of survivors are initially comatose. of those who survive, 50% are left with a permanent neurological disability, and only 10% are able to resume their former lifestyle. early prognosis of comatose patients after cardiac arrest is critical for management of these patients, yet predicting outcome for these patients remains quite challenging. the primary study objective of mocha is to develop an accurate and reliable assessment algorithm for determining neurologic prognosis in patients initially unconscious (no eye opening, gcs-m\<6 and not following commands) post-cardiac arrest, using multiple prognostic modalities at standardized time points.

the investigators will conduct a prospective, international, observational study of cardiac arrest survivors using guideline-recommended prognostic assessment tools with central adjudication of results, while avoiding premature withdrawal of life-sustaining therapy (wlst). the investigators will prospectively collect data on demographics, premorbid characteristics, details of cardiac arrest and resuscitation, post-cardiac arrest care, detailed neurological examination findings, electrophysiologic studies, chemical biomarkers and neuroimaging at standardized time points, and will assess functional outcomes at discharge, 6- and 12-month follow-up, as well as annually up to 5 years. the international cohort will have a derivation subset that will be used to create a multimodal outcome prediction model (using regression analysis), which will then be confirmed by the validation subset. a substudy of mocha will also explore the impact of the practice of wlst in the prediction model by analyzing its performance in a pooled cohort of subjects unexposed to wlst originating from countries where this practice is not common.

Eligibility criteria:
inclusion criteria: * age 18 years and older (no upper age limit) * initially unconscious following cardiac arrest from any non-perfusing rhythm (i.e., ventricular tachycardia, ventricular fibrillation, pulseless electrical activity, asystole) * sustained return of spontaneous circulation (rosc) as defined by maintained spontaneous circulation for at least 20 minutes after cardiopulmonary resuscitation. exclusion criteria: * subjects younger than 18 years of age * isolated respiratory arrest without concomitant or ensuing cardiac arrest

Keywords: coma, prognosis, cardiac arrest
remote social support on midwifery students' anxiety and attitudes during distance education

Conditions: Anxiety

Summary: the aim of this ct is to evaluate the effects of distance social support program on anxiety and attitudes towards distance education with midwifery students during covid-19. the main questions are: 1. does online social support has an impact on attitudes towards distance education? 2. does online social support decrease the anxiety levels of the students? participants will: - join an online social support program and meet the researchers and friends.


Eligibility criteria:
inclusion criteria: * being 2nd or 3rd grade midwifery student * voluntarily participating exclusion criteria: * not using smartphone

Keywords: anxiety distance education pandemics covid-19 social support
zero-fluoroscopic cryoballoon ablation

Conditions: Atrial Fibrillation Paroxysmal

Summary: this study aimed to investigate safety and efficacy of intracardiac echocardiography (ice)-guided zero-fluoroscopic cryoballoon ablation (cba) in patients with paroxysmal atrial fibrillation.

patients (n=100) undergoing de novo cba for paroxysmal af were randomly assigned (1:1) to zero-fluoroscopic (zero-x) and conventional fluoroscopy groups. radiation exposure, procedural time, acute and long term outcome were analyzed.

Eligibility criteria:
inclusion criteria: * patients undergoing de novo cba for symptomatic paroxysmal atrial fibrillation exclusion criteria: * age \< 18 years * history of af ablation or cardiac surgery * contraindication to oral anticoagulants * presence of intracardiac thrombus or significant coronary artery disease on cardiac computed tomography prior to the procedure.
acculif® prospective patient outcomes study

Conditions: Degenerative Disc Disease; Spondylolisthesis, Grade 1; Retrolisthesis

Summary: this is a post-market clinical study of the acculif expandable transforaminal lumbar interbody fusion (tlif) cage in patients requiring surgery for degenerative disc disease (ddd) with up to grade i spondylolisthesis or retrolisthesis, at one or two levels, between l2 and s1.

study evaluations will be evaluated pre-operatively and at 6-weeks, 3-months, 6-months, 12-months and 24-months post-operatively to assess clinical outcomes, patient reported outcomes and radiographic status.

Eligibility criteria:
inclusion criteria: 1. subject is skeletally mature and between 18 and 70 years of age. 2. ddd and up to grade i spondylolisthesis or retrolisthesis, requiring decompression and arthrodesis at one or two contiguous levels between l2 and s1. 3. no previous surgery at the same or adjacent level (other than microdiscectomy / laminectomy) at the same or adjacent level. 4. non-responsive to conservative (non-surgical) treatment for back pain for a minimum of 6 months. 5. subject understands the conditions of enrollment and is willing to sign and date the informed consent. 6. subject agrees to comply with visit schedule and completing study questionnaires. exclusion criteria: 1. significant instability of the spine. 2. requires tlif at more than 2 levels between l2 and s1. 3. previously undergone lumbar spine surgery (other than microdiscectomy / laminectomy) at the same or adjacent level. 4. younger than 18 years of age, or older than 70 years of age. 5. bmi of 40 or greater. 6. history of metabolic bone disease 7. osteoporosis 8. diabetes mellitus requiring daily insulin management. 9. subject has any of the following: 1. progressive neuromuscular disease; or 2. autoimmune disease; or 3. active malignancy within the last 15 years; or 4. active hepatitis; or 5. aids, arc, or is hiv positive; or 6. syringomyelia at any spinal level; or 7. any other condition that would interfere with the subject self -assessment of pain, function or quality of life. 10. allergy to implant materials (titanium, titanium alloy). 11. active systemic infection or infection localized to the site of implantation. 12. primary or metastatic tumors involving the spine. 13. open wounds or inadequate issue tissue coverage over the operative site. 14. history of significant mental illness or mental incapacity. 15. pregnancy or intent to become pregnant. 16. participating in another investigational study for a similar purpose. 17. belongs to a vulnerable population that would compromise ability to provide informed consent or compliance with follow-up requirements. 18. smokers unwilling to cease up to 3 months post-op or recent history of alcohol or other substance abuse within the past 2 years. 19. workers compensation.
developing a whole-body mri and diffusion-weighted imaging state-of-the-art protocol: a pilot study

Conditions: Whole Body Imaging; Cancer; Genetic Predisposition

Summary: whole-body magnetic resonance imaging (wb-mri) is a non-ionizing imaging method that can provide wb coverage using essential imaging contrasts with the possibility to include sequences focusing in specific body-regions as needed per case. wb-mri is increasingly being used for the management of cancer patients, especially metastatic ones. an integral part of wb-mri is becoming whole-body diffusion-weighted mri (wb-dwi) which is a non-invasive tool used for staging and response evaluation in oncologic practice. wb-dwi is an inherently noisy technique, resulting in it accounting for more than 50% of the acquisition time of conventional whole-body mri studies with overall duration at least 1-hour. reducing acquisition times, without compromising image or diagnostic quality would facilitate the wider adoption of clinical wbdwi, reducing costs, and improving the patient experience


Eligibility criteria:
inclusion criteria: * age ≥18 years old; * patients with diagnosis of multiple myeloma, lymphoma, lung, prostate, breast, colorectal and gynecologic cancers; * patients with genetic syndromes responsible for an increased predisposition to neoplasms (e.g. li fraumeni syndrome); * signed written informed consent to personal data treatment for research purposes exclusion criteria: * age \<18 years old; * refusal to sign the written informed consent to personal data treatment for research purposes.

Keywords: mri whole body mri genetic predisposition to cancer
growth hormone for the treatment of gastroparesis

Conditions: Gastroparesis

Summary: the purpose of this study is to determine whether treatment with growth hormone results in symptomatic improvement in patients with gastroparesis.


Eligibility criteria:
inclusion criteria: * symptoms \> 6 months that have not responded satisfactorily to standard treatment. * for gastroparesis: gastroparesis cardinal symptom index (gcsi) score of \>21 exclusion criteria: * known history of gh deficiency, hypothalamic or pituitary disease * diabetes * prior use of gh therapy * age-adjusted low serum igf1 * women on oral estrogen therapy6 * pregnancy or nursing * history of malignant solid tumors * obesity (bmi \> 30)history of coronary and thromboembolic diseases. * history of sarcoidosis * history of pituitary surgery * history of thyroid nodules. * any other condition, which in the opinion of the investigator would impede compliance or hinder completion of the study. * failure to give informed consent.
clinical study comparing dental plaque and gingivitis reduction after using one of three oral hygiene multi-component regimens (using of a manual toothbrush, a toothpaste and a mouthwash)

Conditions: Dental Plaque; Gingivitis

Summary: the objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of a manual toothbrush, a toothpaste containing stannous fluoride / sodium hexametaphosphate and a mouthwash containing cetylpyridinium chloride relative to a negative control regimen in reducing established dental plaque and gingivitis over three and six months of assigned product use.


Eligibility criteria:
inclusion criteria: 1. male and female subjects, ages 18-70, inclusive. 2. availability for the six-month duration of the study. 3. good general health. 4. minimum of 20 uncrowned permanent natural teeth (excluding third molars). 5. initial gingivitis index of at least 1.0 as determined by the use of the loe and silness gingival index. 6. initial plaque index of at least 1.5 as determined by the use of the quigley and hein plaque index (turesky modification). 7. signed informed consent form. exclusion criteria: 1. presence of orthodontic bands. 2. presence of partial removable dentures. 3. tumor(s) of the soft or hard tissues of the oral cavity. 4. advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone). 5. five or more carious lesions requiring immediate restorative treatment. 6. use of antibiotics any time during the one month prior to entry into the study. 7. participation in any other clinical study or test panel within the one month prior to entry into the study. 8. pregnant women or women who are breast feeding. 9. dental prophylaxis received in the past two weeks prior to baseline examinations. 10. history of allergies to oral care/personal care consumer products or their ingredients. 11. on any prescription medicines that might interfere with the study outcome. 12. an existing medical condition which prohibits eating or drinking for periods up to 4 hours. 13. history of alcohol or drug abuse