Kornimate/medical-research-clean huggingface dataset:
taxanes or platinum in combination with capecitabine followed by capecitabine alone as first line treatment for patients with advanced adenocarcinoma of stomach or esophagogastric junction

Conditions: Gastric Cancer

Summary: the purpose of this study is to investigate whether taxanes or platinum plus capecitabine with capecitabine maintenance treatment as 1st line treatment in he advanced gastric cancer is effective and safe.


Eligibility criteria:
inclusion criteria: 1. having signed informed consent 2. age≥ 18 years old 3. histologically confirmed gastric adenocarcinoma 4. unresectable recurrent or metastatic disease 5. previous neo-adjuvant or adjuvant treatment for gastric cancer, if applicable, more than 6 months 6. previous chemotherapy with oxaliplatin or cisplatin or paclitaxel or docetaxel, if applicable, more than 12 months. 7. measurable disease according to the recist criteria 8. ecog performance status ≤2 9. life expectancy of ≥3 month 10. no prior radiotherapy except radiotherapy at non-target lesion of the study more than 4 weeks 11. alt and ast≤2.5 times uln (≤5 times uln in patients with liver metastases) serum albumin level ≥3.0g/dl serum creatinine ≤1.5uln bilirubin level ≤ 1.5 uln wbc\>3,000/mm3, absolute neutrophil count ≥1500/mm3, platelet\>90,000/mm3, hb\>8g/dl exclusion criteria: 1. brain metastasis (known or suspected) 2. previous systemic therapy for metastatic gastric cancer 3. inability to take oral medication 4. previous therapy targeting at angiogenesis or vasculogenesis pathway or other targeted therapy 5. surgery (excluding diagnostic biopsy) within 4 weeks prior to study entry 6. allergic constitution or allergic history to any investigating agents. 7. severe heart disease or such history as recorded congestive heart failure, uncontrolled cardiac arrhythmia, angina pectoris needing medication, cardiac valve disease, severe abnormal ecg findings, cardiac infarction , or retractable hypertension. 8. pregnancy or lactation period 9. any investigational agent within the past 28 days 10. other previous malignancy within 5 year 11. pre-existing neuropathy\>grade 1 12. legal incapacity

Keywords: gastric cancer capecitabine maintenance treatment
aortic elongation and dissection

Conditions: Thoracic Aorta

Summary: aim of this study is to measure length of the ascending aorta in adults and to investigate the clinical implication of 'elongation' of the aorta.

regarding to aortic geometry, attention is often drawn to aortic diameters since an increase in these diameters (e.g. aneurysm) can lead to life-threatening complications such as dissection and/or rupture. in daily practice however (e.g. imaging reports), the investigators often encounter patients with elongation of the ascending aorta. little is known about the length of the proximal aorta. furthermore, the clinical implications of an elongated aorta are unknown.

Eligibility criteria:
inclusion criteria: * underwent recent (\<6 years) contrast-enhanced ct scan which allows for segmentation and assessment of aortic geometry. exclusion criteria: * age \<18 years old. * prior thoracic, cardiac or aortic surgery. * genetic disease with cardiac and/or aortic involvement (e.g. marfan's disease). * infectious disease of the aorta. * malignant disease with involvement of heart and/or aorta.

Keywords: ascending aorta elongation of the aorta type a dissection aortic rupture aortic length
effect of hyaluronic acid on the therapy of alveolar osteitis

Conditions: Alveolar Osteitis

Summary: alveolar osteitis (ao; syn. dry socket) is one of the most frequent complications following tooth removal and it is defined as presence of severe postoperative pain in and around the extraction site, which increases in severity at any time between one and three days after extraction, accompanied by a partially or completely disintegrated blood cloth within the alveolar socket, with or without halitosis, and at the same time excluding any other cause for the pain (blum 2002). to enhance standard treatment of ao, which consists of curettage of the dry socket, rinsing with saline solution, and inducing bleeding from the exposed alveolar bone walls, numerous products have been tested. one of them is hyaluronic acid (hy). the aim of the present study is to investigate the potential effect of hy gel application in the treatment of ao. specifically, the application of hy only (hy test group; n = 20) or the combination of hy and an absorbable collagen sponge (hy+c test group; n = 20) will be compared to standard treatment (blood clot; control group, n=20). clinical and patient related outcome parameters will be recorded for up to 14 days after treatment. a more stable blood clot and thus improved wound healing with faster pain reduction is expected through the use of hy.


Eligibility criteria:
inclusion criteria: 1. \> 18 years; 2. untreated ao after extraction of a permanent tooth (excluding wisdom teeth); 3. diagnosis of ao based on the criteria of blum (blum 2002) exclusion criteria: 4. patients with chronic diseases and/or taking any medication, influencing hard and soft tissue healing; 5. pregnancy; 6. history of hypersensitivity or allergy to hy; 7. inability to attend follow-up appointments; intake of preoperative antibiotics.
"we are an active family": promoting child physical activity through social identity formation in the family system

Conditions: Physical Activity; Social Identity

Summary: the purpose of our study is to explore the effectiveness of physical activity (pa) identity formation in the family system as a promotor of long-term pa. the primary research question is: does a family identity formation condition (with education+planning) result in increased child moderate- to vigorous-intensity pa (mvpa) compared to a standard comparison education and planning condition at six months? hypothesis: child mvpa will be higher for the identity formation condition in comparison to the more standard pa education+planning condition at six months.

the secondary research questions will include: 1. does the identity formation condition improve child health-related fitness outcomes compared to the education and planning condition at six months? hypothesis: child health-related fitness will be higher for the identity formation condition in comparison to the education and planning condition. 2. can group differences among behavioural, and health-related fitness outcomes be explained through a mediation model? hypothesis: the covariance of the assigned conditions (identity formation, planning + education) on child mvpa will be explained by parental support, and through parental support identity (i.e., manipulation check). in turn, the covariance between support and health-related outcomes will be explained by mvpa among conditions. in the case of null outcomes for research question #1, the investigators will instead explore a prediction model of these variables rather than a mediation model. 3. is there an intergenerational, seasonal, or sex difference across primary outcomes by assigned condition? hypothesis: parents in the identity formation condition will show higher physical activity via some activities being performed with their children (as part of social identity) in comparison to the other condition. no differences in child sex or season are hypothesized based on past research.

Eligibility criteria:
inclusion criteria: * participants will be at least one parent with at least one child between the ages of 6 and 12 years. * families (parents and/or guardians and children) residing in greater victoria, nanaimo, ladysmith, duncan, vancouver, richmond, surrey, burnaby, british columbia. * children that participate in \<60 minutes/day of moderate to vigorous physical activity (mvpa) exclusion criteria: * if child is meeting the current physical activity guidelines \>=60 minutes a day of moderate to vigorous physical activity per day. * if participant does not pass physical activity readiness questionnaire (parq)

Keywords: moderate to vigorous physical activity (mvpa) childhood obesity type 2 diabetes identity formation
mr guidance for liver and pancreas

Conditions: Magnetic Resonance Imaging

Summary: this is a single centre, single arm, prospective feasibility study that aims to see whether magnetic resonance imaging (mri) as a source of image guidance before each radiation treatment fraction is feasible, and also if it may provide information that could potentially be used during the treatment to improve the radiation treatment plan. patients will have 5 mris with each of their rt sessions. if patients' rt treatment will consist of more than 5 fractions, only 5 mris will be done with any 5 rt fractions. patients will be completing a short questionnaire at the end of each mri. a patient questionnaire will also be completed at the end of the study to assess for patient satisfaction. there will be 30 evaluable patients enrolled to the study.


Eligibility criteria:
inclusion criteria: * patients 18 years or older * diagnosed with locally advanced pancreatic cancer or hepatocellular carcinoma being considered for treatment with chemoradiation, long course rt, or sbrt with curative intent or palliative intent, planned for 5 or more rt fractions exclusion criteria: - contraindications for mri: ferromagnetic prosthesis, pacemaker / implanted defibrillator, claustrophobia

Keywords: liver cancer pancreatic cancer radiation
paramedical consultation in telemedicine

Conditions: Type 1 Diabetic

Summary: feasibility monocentrique opened study estimating the use of an electronic personalized educational plan (epep) for the follow-up by nurses of 50 patients diabetics type 1 during 6 months having an electronic pad.


Eligibility criteria:
inclusion criteria: * patient diabetic type 1 * patient with the electronic pad in a smartphone * adults * children between 12 and 17 years 11 months * patient having signed the consent exclusion criteria: * patient diabetic type 2 * patient without the electronic pad in a smartphone * children below 12 years old

Keywords: telemedecine telemedecine nurse delegation of tasks type 1 diabetes
treatment patterns, outcomes and resource use study for advanced stage non-small cell lung cancer (squamous and non-squamous) in the kingdom of saudi arabia and united arab emirates

Conditions: Lung Cancer

Summary: a retrospective observational longitudinal medical chart review study of randomly sampled patients diagnosed with advanced/metastatic nsclc. the minimum observational period for each patient will be 12 months.


Eligibility criteria:
inclusion criteria: * adults 18 years and older at the time of advanced/metastatic nsclc diagnosis, and currently alive or deceased * histologically confirmed diagnosis of advanced/metastatic nsclc (squamous, non-squamous or nos) stages iiib/iv. first diagnosis of advanced/metastatic nsclc between 01-jan-2010 and 31-mar-2014 (currently alive or deceased) with a minimum 12 months of potential observation period available in medical records * medical history and treatment data must be available (or obtainable by si) for chart abstraction from the date of advanced/metastatic diagnosis through most recent patient follow-up/contact. this also includes documentation of treatment by other physicians and inpatient hospital treatments within ksa or the health authority of abu dhabi (haad) system * patients must have at least all data on age, gender, date of advanced nsclc diagnosis, line of treatment (lot) information (agent types and dosage), and date of last follow-up exclusion criteria: * patient had enrolled in a cancer treatment-related clinical study at any time after the diagnosis of advanced/metastatic nsclc
virtual reality approach in multiple sclerosis

Conditions: Rehabilitation; Multiple Sclerosis

Summary: the aim of our study is to investigate the effects of game-based virtual reality exercise added to conventional physiotherapy and rehabilitation program in patients with multiple sclerosis (ms). in order to evaluate its effectiveness, assessment of pain, range of motion and disability will be applied.

multiple sclerosis (ms) is a neuromuscular disease that causes various degrees of disability in mobility and functional activities, causing restrictions on the individual's social and professional life, creating advanced disability and impairing quality of life. problems in upper limb function affect quality of life and functional independence of the patients. recovery of restricted daily life functions (such as dressing, personal care, eating and body care) is one of the main goals of physiotherapy and rehabilitation in ms and currently, conventional physiotherapy and rehabilitation methods are most commonly used. the main purpose of this method is to reduce pain, increase range of motion and muscle strength. with the developing technology various virtual reality applications have begun to take place in physiotherapy and rehabilitation programs recently. these virtual reality applications are used to motivate the patient and keep their interest in the rehabilitation. the aim of our study is to investigate the effects of game-based virtual reality exercises added to conventional physiotherapy and rehabilitation program in patients with ms.

Eligibility criteria:
inclusion criteria: * volunteered to participate in the study, * aged 18-65 years * having a score between 1.5 - 7 according to expanded disability status scale (edss) exclusion criteria: * any visual or hearing problem, * other neurological, orthopedic or rheumatic problems that may restrict shoulder motion or cause pain, * having a physical disability or uncontrolled chronic systemic disease, * major trauma, * treatment for shoulder problems within the last 6 months, * history of epileptic attacks * not being stable for ms attacks during the last 3 months

Keywords: rehabilitation physiotherapy and rehabilitation virtual reality multiple sclerosis upper extremity
evaluating the efficacy and quality of life impact of transitioning to advanced hybrid closed-loop insulin pump therapy in romanian children with type 1 diabetes mellitus

Conditions: Diabetes Mellitus, Type 1

Summary: the proposed study aims to demonstrate the potential benefits of transitioning t1dm children from predictive low glucose suspend insulin pump therapy to advanced hybrid closed-loop insulin pump therapy in romania. primary outcome: variations in hba1c between baseline visit (v1 - 740g) and assessment visit following three months of 780g insulin pump therapy (v2 - 780g). secondary outcomes: changes in insulin requirements, time in range (tir) levels, time below range (tbr), coefficient of variation (cv), frequency of severe hypoglycemic and hyperglycemic events requiring hospitalization, and pedsql sf15 questionnaire scores.


Eligibility criteria:
inclusion criteria: * age 7 years or older at baseline * diagnosis of type 1 diabetes * current use of a predictive low glucose suspend insulin pump (740g) * at least 30% of subjects must have an hba1c \> 7,5% (58 mmol/mol) exclusion criteria: * age \< 7 years or ≥ 18 years at baseline * diabetes duration \< 1 year at baseline * hba1c ≤ 7% (53 mmol/mol) * not meeting the romanian national standards for closed-loop insulin pump therapy * other criteria deemed inappropriate by the principal investigator (to be documented)

Keywords: hba1c insulin pumps closed-loop
pelvic angioembolization: a prospective multi-institutional study (data from all campuses will be used)

Conditions: Pelvic Hemorrhage

Summary: the investigator's propose a multicenter prospective observational study to investigate the use of embolization in patients with negative angiogram and to ascertain the optimal level of treatment when the angiogram is positive; non-selective vs. selective embolization.

the investigator's propose a multicenter prospective observational study to investigate the use of embolization in patients with negative angiogram and to ascertain the optimal level of treatment when the angiogram is positive; non-selective vs. selective embolization. the investigator's will divide patients into groups based on positive or negative angiogram. within each group the investigator's will compare those embolized and level of embolization. all blunt trauma patients undergoing angiography for pelvic fracture associated hemorrhage will be eligible for the study. demographic, physiologic, operative, and post-operative data will be collected including blood product resuscitation, classification and management of pelvic fracture, associated injuries, angiographic details, complications, outcomes and overall injury burden. the study population will be stratified based on presence of arterial hemorrhage on initial angiogram (positive or negative angiogram) and then further stratified based on performance of embolization. nse will be defined as embolization of the main internal iliac artery, either unilaterally or bilaterally and se as any embolization distal to the main internal iliac artery. bivariable and multivariable analyses will be performed to determine differences in pelvic hemorrhage as measured by transfusion necessity and quantity of products required, complications and to identify independent risk factors for outcome variables. a power analysis was performed based off of thromboembolic complication difference in selective vs. non selective embolization and then again with blood transfusion requirement difference in embolized vs. not embolized for those who have no evidence of arterial bleeding on angiogram (ie the two questions the investigator's are trying to answer).the investigator's plan to complete the data collection and analysis by 1/1/2019.

Eligibility criteria:
inclusion criteria: * • all blunt trauma patients undergoing angiography for pelvic fracture associated hemorrhage exclusion criteria: * • pregnant patients * patients \< 18 years old * patients undergoing angiography greater than 24 hours from arrival
the virtue post marketing surveillance registry

Conditions: Aortic Dissection

Summary: the purpose of this post-market release registry is to collect additional information concerning safety, performance and health economic data with respect to the medtronic valiant thoracic stent graft with the xcelerant delivery system in the treatment of descending thoracic aortic dissections.

the patient device for use in this registry is the medtronic valiant thoracic stent graft system that received ce mark approval in march 2005. the medtronic valiant thoracic stent graft with xcelerant delivery system is designed to treat diseases of the descending thoracic aorta including but not limited to aneurysms and dissections. the valiant stent graft is designed to exclude the aneurysm, the false lumen or site of rupture and restore the blood flow through the stent graft lumen. the device is intended for use either in patients who are candidates for conventional surgical repair, and in patients who are not candidates for conventional surgical repair due to pre-existing risk factors. this registry is a prospective, non-randomized, single-arm, multi-center, european clinical registry with patients diagnosed with descending thoracic aortic dissection. for this registry standard hospital procedures with respect to patient interventional care for thoracic aortic diseases will be followed. this is a descriptive registry in which no specific hypotheses will be statistically tested.

Eligibility criteria:
inclusion criteria: * patient will be more than or equal to 18 years of age; or older if required by local regulations. * patient has an indication for treatment by either endovascular stent graft implantation for either an acute, sub-acute or chronic type b dissection. * patient is amenable for stent-graft treatment (in accordance with the ifu). * the patient is willing and able to cooperate with registry procedures and required follow-up visits. * the patient or legal guardian has signed a patient informed consent form, including data privacy authorization (this criteria is not applicable for patients presenting in emergency with ruptured dissection and for whom legal representative is not available informed consent can be requested after surgical procedure). exclusion criteria: * patients with a thoracic dissection for which optimal treatment is observation and medical management. * patient with current - non aortic - medical condition with a life expectancy less than one year. * the patient is participating in another device or drug study (patient must have completed the follow-up phase of any previous study at least 30 days prior to enrolment in this registry). * time interval between medical indication for surgical intervention and endovascular procedure exceeds 4 months (122 days).

Keywords: descending thoracic aortic dissection valiant medtronic type b virtue stent
muco smartphone exacerbation

Conditions: Cystic Fibrosis

Summary: exacerbation in cystic fibrosis play an important role in terms of mortality and morbidity. exacerbation frequencies is relatedto fev1 decline and mortality. there is a relationship between exacerbation frequency and qoldeterioration. moreover exacerbation treatments present health costs burden leading to important physical psychological and social impact. preventing exacerbation and early detection of these exacerbations may decrease intensity and freqauency of exacerbation leading to increase clinical status and qolwith a decreased health cost. patients actually follow in crcm track exacerbations when visits out patient clinic and during phone call. if patients did not call or did not present regularly to out patient clinic, exacerbation detection came later and so increasde the burden and therapeutic pressure. the objective of our study is to identify earlier the potential exacerbations and so decreased the health costs and increased the patient's qol. forthis purpose we propose to use modern technologiessuch as smartphone in order to create alert when patients report weekly health satatus. we will compra patients randomize in control group with standart follow-up to patients randomize in the smartphone group.moreover we will study the compliance and satisfactory degree of the use of this device in the interventional arm.

exacerbation in cystic fibrosis play an important role in terms of mortality and morbidity. exacerbation frequencies is relatedto fev1 decline and mortality. there is a relationship between exacerbation frequency and qoldeterioration. moreover exacerbation treatments present health costs burden leading to important physical psychological and social impact. preventing exacerbation and early detection of these exacerbations may decrease intensity and freqauency of exacerbation leading to increase clinical status and qolwith a decreased health cost.

Eligibility criteria:
inclusion criteria: * cf diagnosis * patient able to receive phone call * patient who use regulary a smartphone * age from 14 to 25 * patients with at least 2 exacerbations before the entry. * stable patient at v1 exclusion criteria: * patients who are include in an interventional study * patient who is not able to read french language * patients with psychological disorder

Keywords: exacerbation, qol
factor xi inhibition for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty

Conditions: Knee Arthroplasty, Total

Summary: this study was to compare the study drug kn060 to enoxaparin, for the prevention of blood clotting and safety in patients undergoing total knee arthroplasty (tka).


Eligibility criteria:
inclusion criteria: 1. male or female, aged between 18 and 75 years old (including the cut-off value); 2. undergoing unilateral total knee arthroplasty (tka); 3. voluntarily participate in the study and sign a written informed consent; exclusion criteria: 1. there is a high risk of bleeding or abnormal bleeding related indicators: 2. evidence of venous thrombosis, such as the presence of related symptoms or auxiliary tests indicating thrombosis; or have a history of venous embolic disease. 3. acute myocardial infarction or ischemic stroke occurred within 6 months before screening. 4. presence of malignant tumors or history of malignant tumors.