Kornimate/medical-research-clean huggingface dataset:
iron stores and skeletal muscle metabolism in chronic heart failure

Conditions: Chronic Heart Failure

Summary: iron deficiency may contribute to exercise intolerance by altering mitochondrial oxidative capacity in skeletal muscle. functional iron deficiency is common in heart failure patients, but the relationship to exercise intolerance and mitochondrial oxidative capacity is unknown. this is a pilot study to determine the feasibility of the use of specialized 31p-mrs and mri techniques for measurement of skeletal muscle bioenergetics in patients with heart failure with and without functional iron deficiency.

this study will obtain pilot feasibility data to explore the relationship between blood biomarkers of functional iron deficiency and skeletal muscle mitochondrial oxidative capacity with 31p-magnetic resonance spectroscopy (mrs) and imaging in heart failure patients. twenty (20) subjects will be recruited from the clinical practice of the nyu advanced cardiac therapeutics group at nyu langone medical center. twenty (20) subjects will be recruited from the practice of the nyu advanced cardiac therapeutics group at nyu langone medical center. the study will require a maximum of four (4) visits over a period of five (5) weeks. eligibility for visits 2-4 will be determined by the screening criteria in visit 1. it is anticipated that 50% of the screened subjects at visit 1 will be eligible to participate in visit 2. eligibility for participation in visits 3 and 4 will be determined by the results of the iron biomarkers obtained at visit 2. we anticipate that 50% of the subjects at visit 2 will be eligible to participate in visits 3 and 4. only subject with functional iron deficiency will participate in visits 3 and 4. there is no clinical care component for this study.

Eligibility criteria:
inclusion criteria: * able and willing to provide written informed consent * age 21-80 years * chronic heart failure \>3 months with nyha class i-iii symptoms exclusion criteria: * presence of implantable defibrillator, permanent pacemaker not designed for safe use in 3t mri stud * metallic implant or implants that are deemed not suitable for mri scan on 3t * aneurysm clips, cochlear implants, presence of shrapnel in strategic locations, and metal in the eye * known claustrophobia or any other history of intolerance of mri procedure * treated diabetes mellitus or hemoglobin a1c (hba1c) \>6.5% * any hospitalization \<60 days * myocardial infarction or stroke \< 6 months * estimated glomerular filtration rate \<30 ml/min * weight \ 120 kg * systolic blood pressure \ 160 mmhg * heart rate \ 100 beats per minute * resting oxygen saturation on room air \<92% * hemoglobin \<11 g/dl * serum phosphate below normal range (\<2.4 mg/dl) * liver function tests (ast, alt, alk phos, or total bilirubin) \>twice upper limit of normal range * pregnancy or current breastfeeding * exercise limitation primarily due to valvular heart disease, lung disease, neuromuscular disease, or joint disease * history of asthma * history of anaphylaxis * known history of intolerance to any formulation of intravenous iron

Keywords: iron deficiency
retail outlet health kiosk hypertension trial

Conditions: Hypertension

Summary: the investigators propose to conduct pilot studies to support an application to conduct a fully powered randomized trial of a text messaging intervention to increase the rate of blood pressure control, defined as \<140/90 mmhg, among hypertensive individuals using health kiosk blood pressure devices. these pilot studies will include testing of the intervention, recruitment, enrollment, and data collection procedures, and of the web-based interactions between the data coordinating center and higi sh llc (chicago, il), which is the company that installs and maintains the health care kiosks and associated software infrastructure. completion of these pilot studies will provide preliminary data to support an application for a full scale randomized controlled study. potential for adaption is high because of alignment of retail outlets, kiosk providers, and consumers for health, wellness, and self-care.

cardiovascular disease (cvd) remains the leading cause of death in the u.s. as well as the leading cause of health care cost. hypertension is the leading remediable risk factor for cvd in the u.s. and globally, with prevalence of 29% in u.s. adults. recent data from nhanes indicate that blood pressure (bp) is not controlled, defined as \ 3 systolic bp measurements \>140/90 mmhg. the investigators propose to target this group using interactive text messaging to activate individuals to take actions to improve bp control. the primary endpoint will be bp control defined as \<140/90 mmhg at 12 months post randomization.

Eligibility criteria:
inclusion criteria: * \>3 systolic blood pressure measurements \>140/90 mmhg (two in the previous 12 months + one at baseline) * age 18-85 years * weight \<300 pounds * has a cell phone * can provide consent * speaks english or spanish

Keywords: text messaging
air tamponade in macular holes < 400 μm

Conditions: Macular Holes

Summary: macular hole is a hole formation which takes place in the center of the retina. such a hole needs surgical steps in order to close. closure of the macular hole will lead to a substantially improvement of vision in most cases. following macular hole surgery a tamponade of intraocular gas is normally injected in order to keep the macula dry for the postoperative period. postoperative face down position for a week was earlier standard. several authors report of good closure rates with both air tamponade or lack of face down positioning. in this study standard pars plana vitrectomy with peeling of the internal limiting membrane (ilm) will be performed. the gas tamponade will be replaced by air. postoperative face down positioning will not be used. only macular holes less than 400 μm will be included.


Eligibility criteria:
inclusion criteria: * primary macular hole less than 400 μm in diameter * duration of symptoms less than 36 months * informed consent exclusion criteria: * previous vitreomacular surgery * myopia more than 6 diopters * ocular trauma * disease affecting visual function

Keywords: macular hole vitreoretinal surgery macular surgery air tamponade
cgm in patients with ed's

Conditions: Anorexia Nervosa Restricting Type; Anorexia Nervosa, Binge Eating/Purging Type; ARFID; Avoidant Restrictive Food Intake Disorder

Summary: to determine the accuracy of continuous glucose monitoring (cgm) with point of care (poc) fingerstick glucose monitoring and venous blood glucose in patients with eating disorders, specifically anorexia nervosa, restricting subtype (an-r); avoidant/restrictive food intake disorder (arfid); and anorexia nervosa, binge/purge subtype (an-bp).

it is the experience of the treatment team at acute center for eating disorders and severe malnutrition that poc fingerstick testing can be inaccurate in patients when poc fingerstick testing is compared to serum glucose values. however, this has not been formally studied. this study seeks to define the accuracy of poc fingerstick testing and cgm as compared to blood serum glucose monitoring via phlebotomy. it also seeks to better understand the frequency of hypo- and hyperglycemia in this population using continuous glucose monitoring during the first 10 days of admission. ideally, an accurate method of monitoring glucose values in this population beside phlebotomy draws needs to be established. blood will be drawn shortly after participants admission to the unit as part of usual care and will continue to be drawn daily as usual care for the next 5 days. patient blood sugar will be checked daily using poc finger sticks until hypoglycemia resolves. if patient choose to participate in this study, the investigators will do additional poc testing on days 6 and 8 poc finger sticks will be done 30-minutes post breakfast/lunch/dinner. on the same day the patient agrees to be in this study, the patient will have a dexcom cgm placed to the back of their arm, or on another area of the body depending on the recommendation from the manufacturer (dexcom). patient will wear the cgm for the full 10 days that the study is being conducted. patient will also be asked to complete a simple log regarding the date and time the patient received post breakfast/lunch/dinner poc tests on days 6 and 8. the patient may ask the psca patient safety care attendant (psca) to assist patient with this task. data received from the dexcom device will automatically be uploaded to the dexcom cloud. only the research statistician will have access to these data. staff from dexcom do not have access to these data.

Eligibility criteria:
inclusion criteria: * ages 18-65 and meet the dsm-v criteria for an-r or an-bp or arfid * admission %ibw ≤ 75% exclusion criteria: * diagnosed with an eating disorder other than an-r or an-bp or arfid * %ibw \> 75% on admission * inability to give informed consent to participate/lacks decisional capacity * unable to follow the study protocol * transferred to the unit on a mental health hold/short term certification * treatment team refusal of patient's participation

Keywords: cgm continuous glucose monitor acute
regulation of human intestinal bile acid transport in health and disease

Conditions: Gastrointestinal Diseases

Summary: this study investigates distribution and regulation of bile acid transport in the human intestine.


Eligibility criteria:
veterans, healthy, scheduled for screening colonoscopy
onduo virtual diabetes clinic study

Conditions: Diabetes Mellitus, Type 2

Summary: this is a prospective, single arm study designed to evaluate the change in hemoglobin a1c after 4 months of participation in the onduo virtual diabetes clinic (vdc) in individuals with type 2 diabetes and suboptimal glycemic control.

the onduo virtual diabetes clinic (vdc) is the suite of diabetes management services accessed via a software application (onduo app). eligible subjects are asked to use the onduo app and commercially available fda-regulated medical devices and non-medical devices, for up to 4 months. subjects receive a continuous glucose monitor (cgm) and are asked to use the device for up to 6 wear cycles of 10 days each. subjects are scheduled for a medical review via a face-to-face telemedicine consultation with a vdc physician. subjects may have their diabetes medications changed by a vdc physician following their telemedicine visit. information provided to a subject in the course of the study is not intended as a substitute for the subject's primary care provider's guidance. at the completion of the subject's study participation, the onduo app will be deactivated and there will be no further data collection through the app. a1c levels and surveys are collected at 1 year follow-up.

Eligibility criteria:
inclusion criteria: * male and female; 18 years of age or older * confirmed diagnosis of type 2 diabetes mellitus * willing to use cgm and bgm * a1c result ≥8.0% and ≤12.0% * receive their diabetes care from premier medical associates or the palo alto medical foundation * own a smartphone with a data plan and be the primary user of that smartphone * smartphone must use a supported android os or ios exclusion criteria: * pregnant or breastfeeding * use of an insulin pump * any condition or situation that the sponsor or investigator determines as inappropriate for study inclusion
prevalence rate, and clinical characteristics of obesity hypoventilation syndrome via screening patients admitted to medical intensive care units

Conditions: Obesity Hypoventilation Syndrome

Summary: a prospective observation study to screen adult obese (bmi ≥30 kg/m2) patients who were newly admitted to the medical intensive care units and turned out to be diagnosed as obesity hypoventilation syndrome(ohs). the investigators purpose is to look into the prevalence, predictive factors, and outcomes of ohs in these critically ill patients.


Eligibility criteria:
inclusion criteria: * bmi ≥ 30 kg/m2 * suspected chronic hypercapnia as following paco2 ≥ 45 mmhg, hco3- ≥ 27meq/l or base excess, be ≥ 2 meq/l exclusion criteria: * malignancy with lung involvement * autoimmune disease with lung involvement * moderate to severe obstructive respiratory pattern via spirometry * uncontrolled endocrine disease * pregnancy * pneumonia confirmed by image * out-of-hospital cardiac arrest * lung edema * foreigner of taiwan
comparative study of antiperistaltic vs isoperistaltic billroth ii + braun anastomosis for postoperative reflux

Conditions: Gastric Cancer; Postoperative Complications

Summary: postoperative gastroesophageal reflux is one of the most common complications of distal gastrectomy. with more attention paid on it by surgeons, several new operation methods have been practised. among all these, distal gastrctomy with billroth ii + braun anastomosis was reported to be an useful method to decrease postoperative reflux rate. meanwhile, the direction of anastomotic peristalsis has also been reported to affect the anastomosis and thus make difference in reflux rate. we design this study to investigate the potential effect and the superiority of antiperistaltic vs isoperistaltic billroth ii + braun reconstruction in distal gastrectomy.


Eligibility criteria:
inclusion criteria: * pathologically diagnosed as gastric cancer before surgery * clinical staging: ct1-4an0-3m0 * postoperative evaluation concluded b-ii b anastomosis * consent assigned exclusion criteria: * diagnosed with other malignancies within 2 years * gastric cancer with clinical staging: ct4b or m1 * women with pregnancy or breast-feeding * emergency procedures * consent not assigned

Keywords: distal gastrectomy postoperative reflux rate gastric cance laparoscopic surgery
effect of photobiomodulation for patients with xerostomia

Conditions: Photobiomodulation; Low-Level Light Therapy

Summary: hyposalivation is a condition represented by a reduced salivary flow and may include symptoms such as mouth dryness (xerostomia), pain, loss of taste,dysphagia, and dysphonia, all of which greatly affect an individual's quality of life. the aim of the present study was analized the effects of low-level light therapy irradiation (photobiomodulation pbm) on salivary gland function in patients with hyposalivation

inclusion criteria -the inclusion criteria for participating in the study were: age over 18 years; continuous xerostomia for over three months; and/or altered sialometry findings at baseline (salivary flow \< 0.1 ml/min). exclusion criteria. : xerostomia as secondary to radiotherapy; patients with decompensated systemic disorders or cognitive problems the 60 individuals will be randomized in 2 groups: group a (30 individuals submitted to treatment with a pbm) and group b (30 individuals submitted to simulated pbm). a total of 60 patients with xerostomia were enrolled in the study and cited once a week for a period of 6 weeks treatment with diode laser (810nm, 6j/cm2) or sham treatment (according to the group).

Eligibility criteria:
inclusion criteria: * the inclusion criteria for participating in the study were: age over 18 years; continuous xerostomia for over three months; and/or altered sialometry findings at baseline (salivary flow \< 0.1 ml/min). exclusion criteria: * the exclusion criteria were: xerostomia as secondary to radiotherapy; patients with decompensated systemic disorders or cognitive problems
sliding sign in late trimester ultrasound evaluation of intra-abdominal adhesions in women undergoing repeat cs

Conditions: Cesarean Section Complications

Summary: predicting the presence of severe adhesions may also assist clinically in several ways: first, it allows allocation of more complicated surgeries to experienced surgeons; second, the surgeons can plan and prepare better for the surgery if they know in advance whether they are going to operate a complicated surgery; third, a difficult surgery may be scheduled to be performed in an experienced center, preparing cross match blood units, and alerting the general surgeon and urologist of the potential risk for surgical complications, saving time if intervention is required. this information can permit preoperative planning by a multidisciplinary team of surgeons and allow the patient to be informed of the potentially high risk of complications.

the incidence of repeat cesarean delivery is on the rise worldwide, approximately 90% of women with a prior cesarean delivery undergo a planned repeat cesarean delivery in their next pregnancy. post-cesarean adhesions are a major complication in subsequent surgeries, causing an increased risk for bladder and bowel injury (0.1-0.3%), hemorrhage (0.1-1.4%), infection (0.4-1.6%), and even hysterectomy (0.1-1.4%). in addition to the risk associated with the pelviabdominal surgical procedure itself, adhesiolysis may result in injury to adjacent viscera, blood loss, and in case of emergency cesarean delivery, to the perinatal adverse outcome associated with delayed delivery of the neonate. this represents a considerable healthcare issue, as it has a significant impact both on the patient, increasing morbidity and mortality, and on healthcare costs. it is therefore important for surgeons to detect patients at high risk of having adhesions. women suspected to have severe intra-abdominal adhesions may benefit from appropriate preparation of blood products, better assignment of surgeons, request for preoperative surgical assistance of other medical specialties, and possibly performance of a midline skin incision to enter the peritoneal cavity. it is therefore important for surgeons to detect patients at high risk of having adhesions. various means have been proposed to predict adhesions prior to surgery, including analysis of patient characteristics and appearance of the scar, as well as the intraoperative peritoneal adhesion index.

Eligibility criteria:
inclusion criteria: 1. history of previous cesarean section. 2. gestational age: full-term. 3. scheduled to undergo elective cesarean section. exclusion criteria: 1. body mass index more than 40 on admission. 2. abnormal placental invasion. 3. having known collagen disease. 4. unplanned or emergency repeated cesarean delivery. 5. history of abdominal surgery.
fmri in impulsivity

Conditions: Impulse Control Disorders; Borderline Personality Disorder

Summary: this study aims to use resting-state and task based functional magnetic resonance imaging (fmri) as a tool to evaluate trait characteristics of impulsivity in subjects with borderline personality disorder.


Eligibility criteria:
inclusion criteria: * healthy controls: volunteers (age 18-50 yrs) in generally good psychiatric and non-psychiatric medical health * borderline personality disorder subjects: research volunteers (age 18-50 yrs) who meet dsm-5 criteria for borderline personality disorder exclusion criteria: all participants: * current medications which affect the central nervous system or vascular activity, such as anti-depressants, anxiolytics, or blood-pressure medications * positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines * positive breathalyzer test for alcohol * history of clinically significant neurologic disorders or head trauma with loss of consciousness greater than 30 minutes * clinically significant non-psychiatric medical disorder requiring ongoing treatment. * unwillingness or inability to sign a written informed consent form * pregnancy as assessed by a urine test for ß-hcg at each visit * medical or physical contraindications for participation based on medical history interview, labs, and physical exam * metal fragments or other bodily metal (e.g., pacemaker, orthopedic prosthesis),claustrophobia, or any other condition that would put the subjects at risk for mri scanning in addition, healthy controls excluded, if: * dsm-5 diagnoses of personality disorders (based on scid-ii) * dsm-5 diagnoses based on the scid-i (including the eating disorders module) * history of arrest or incarceration in addition, borderline personality disorder subjects excluded if: * dsm-5 diagnoses * dsm-5 personality disorder other than cluster b personality disorders * current psychoactive medications * further exclusion criteria apply
impact of breast magnetic resonance imaging (mri) on mastectomy rates

Conditions: Early Stage Breast Cancer

Summary: the primary goal of this study is to determine if preoperative breast mri findings resulted in more extensive surgery, i.e., mastectomy than breast conserving surgery, i.e., lumpectomy in early stage breast cancers at summa akron city hospital. early stage breast cancer is defined as breast tumor size less than 5 cm. the objectives are to: * review early stage breast cancer patient cases treated at summa akron city hospital between 2006 and 2009 to evaluate clinical and pathological staging * determine the results of preoperative breast mri and the impact on type of surgery performed * evaluate the decision to have mastectomy rather than lumpectomy, i.e., physician or patient decision and if this decision was based on breast mri findings

early stage breast cancer cases between 2006 and 2009 will be identified by the summa akron city hospital cancer registry. the cases will be reviewed and abstracted. the abstracted data will include results of physical breast examinations, mammograms, sonograms, breast mri reports, biopsy procedure notes and pathology reports to illustrate the clinical stage. definitive surgical pathology reports will be included in the abstracted data to demonstrate the final pathologic stage of the breast cancer. a database will be developed to capture the abstracted data. outcomes will be determined based on final pathology reports.

Eligibility criteria:
inclusion criteria: * early stage breast cancer between 2006-2009 * preoperative mri exclusion criteria: -

Keywords: early stage breast cancer preoperative breast mri mastectomy
embrace1: prostate biorepository

Conditions: Prostate Cancer

Summary: the objective of this multi-center prospective observational clinical study is to evaluate the clinical performance of the carisome prostate assay as an aid in the diagnosis of prostate cancer in men that have been scheduled for a prostate biopsy. primarily, results of the carisome prostate assay will be compared with pathology results of prostate biopsy procedures. secondarily, the performance of the carisome prostate test will be compared to the current standard of care for the detection of prostate cancer.


Eligibility criteria:
inclusion criteria: * men scheduled for a routine prostate biopsy expected to produce a pathology evaluation and report * blood draw within 7 days prior to scheduled prostate biopsy procedure * blood draw on the day of but prior to biopsy exclusion criteria: * any previous diagnosis of cancer with the exception of non-melanoma skin cancer * any prior or ongoing treatment for prostate cancer including prostatectomy or hormone therapy * prostate biopsy within one month of blood draw * previous enrollment in the caris life sciences biorepository