Kornimate/medical-research-clean huggingface dataset:
comparison of innovative rehabilitation treatments and examination of their effectiveness in stroke patients

Conditions: Stroke

Summary: we perform a comparison of several groups. we would like to determine how robotic and virtual therapy is most effective in the treatment of stroke patients. we place great emphasis on walking speed, quality of life, coordination and changes in walking distance.


Eligibility criteria:
inclusion criteria: post stroke 6mwt : 120\> minimum after stroke 3 days be a stroke patient first stroke hemiplegia exclusion criteria: multiple strokes, inability to stand and walk, cognitive function disorder does not reach 50 meters with a minimal walking aid alcohol sever heart problem sever demeanor alcoholism drug problems drug

Keywords: robotic stroke rehabilitation virtual rehabilitation
hfno in pneumonia patients presenting with acute hypoxemic respiratory failure

Conditions: Pneumonia

Summary: high-flow nasal oxygen (hfno) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (ahrf). to evaluate whether early use of hfno in pneumonia patients with (ahrf) can reduce the need for invasive ventilation.

* pneumonia adults patients (age\>18 years) with ahrf were eligible for this study after conventional oxygen therapy failure. * the criteria for diagnosing ahrf were defined as the presence of a respiratory rate (rr) more than 25 breaths/min with spo2 less than 92%, and/or the arterial oxygen partial pressure (pao2) to fio2 ratio less than 300 mmhg while breathing oxygen delivered by a conventional venturi device at a fraction of inspiration oxygen of 0.5 (as per maximum for venturi mask) administered for at least 60 minutes. eligible patients were randomized to receive either hfno or niv respiratory support throughout the hospitalization period. randomization was stratified by a laboratory scientist not involved in the study using the technique of shuffled sealed envelopes.

Eligibility criteria:
inclusion criteria: * pneumonia adults patients (age\>18 years) with ahrf were eligible for this study after conventional oxygen therapy failure. * the criteria for diagnosing ahrf were defined as the presence of a respiratory rate (rr) more than 25 breaths/min with spo2 less than 92%, and/or the arterial oxygen partial pressure (pao2) to fio2 ratio less than 300 mmhg while breathing oxygen delivered by a conventional venturi device at a fraction of inspiration oxygen of 0.5 (as per maximum for venturi mask) administered for at least 60 minutes. exclusion criteria: * patients requiring emergency intubation, * recent esophageal, facial, or cranial trauma or surgery, * severely decreased consciousness (glasgow coma scale \[gcs\] of 11 or less), * severe hemodynamic instability (patient on inotropic or vasopressor support), ° severe ventricular arrhythmia or myocardial ischemia, * tracheotomy or other upper airway disorders, * active upper gastrointestinal bleeding, and * inability to clear respiratory secretions .
inflammatory and fibrotic markers and atrial fibrillation

Conditions: Atrial Fibrillation

Summary: inflammatory and fibrotic protein markers in patients with atrial fibrillation


Eligibility criteria:
inclusion criteria: * patients with atrial fibrillation exclusion criteria: * patients with atrial fibrillation who are reluctant for the study
arrested versus beating heart techniques in coronary revascularisation

Conditions: Coronary Artery Bypass Grafting

Summary: the individual contribution of the specific injuring mechanisms surgical trauma, extracorporeal circulation, and ischemia/reperfusion to clinical outcome in coronary revascularisation remains to be elucidated. the effect of these factors is analyzed in this randomized clinical trial by comparing the 3 surgical approaches: conventional coronary artery bypass grafting (ccab), with extracorporeal circulation and cardioplegic arrest; off-pump coronary artery bypass grafting (opcab), avoids extracorporeal circulation and global myocardial ischemia; and pump-assisted coronary artery bypass grafting (pacab), with an unloaded and beating heart. the hypothesis addressed by the study is that the surgical invasiveness increases in the order: opcab, pacab, ccab.


Eligibility criteria:
inclusion criteria: * patients with double- or triple-vessel coronary artery disease * patients with left ventricular ejection fraction =\ = 60% * elective or urgent isolated coronary artery bypass grafting exclusion criteria: * previous cardiac surgery * emergency indications

Keywords: coronary disease coronary artery bypass grafting cardiopulmonary bypass extracorporeal circulation cardioplegia off pump
ionized magnesium in athletes

Conditions: Magnesium Deficiency

Summary: ionized magnesium variation is measured during a normal day and again during a day with an exercise protocol of 90 minutes.

magnesium is an essential micronutrient for health and exercise performance. deficiencies are common, especially in case of insufficient diets. athletes are a population at risk of magnesium deficiency, as they can have strong nutritional (dis)believes and increased losses through sweat. that is why monitoring magnesium status in athletes is very important. ionized magnesium is the active form of total magnesium, this value might be even more important than total magnesium. however, whether ionized magnesium is influenced by day variation is not clear yet. in addition: one bout of exercise can change magnesium status and probably ionized magnesium status. for people active in sports it is important to be aware of this variation in magnesium status, to prevent the diagnosis of false inadequate magnesium status. therefore it is the aim of this proposal to determine whether ionized magnesium varies within one day and whether it changes after an acute bout of exercise. objective: the main objective is to investigate whether ionized magnesium concentration varies during one day, and whether it is changed after one bout of exercise study design: this will be a cross-over design. with screening and preliminary tests before the exercise test day and the non-exercise test day. the order in which exercise day and non-exercise day will be done, will be randomly divided between the participants. intervention: a rest day and an exercise day at exercise day: an exercise test of 90 min at 70% of vo2max. blood samples are taken at set time points during rest day and exercise day

Eligibility criteria:
inclusion criteria: * age: 18 - 45 y * bmi: 18.5 - 25 * minimal of 5 hours of training per week, for at least 2 years * used to bike, at least 5 hours per week in high season * no mg and / or ca supplementation during study * no blood donation, during or in the 6 weeks preliminary the study * suitable veins * no chronic medication, with the exception of paracetamol and or birth control * no antibiotics in the month preliminary the study * good health * serum mg \> 0.7 mmol/l * willing to give blood * able to be present and participate at all test days exclusion criteria: * chronical illness * use of medication with the exception of paracetamol and or birth control * mg and or ca supplementation use * inadequate mg intake (according to ffq) * working at human nutrition * wageningen university msc thesis or internship at human nutrition * participating in other scientific research (with the exception of eetmeetweet)

Keywords: exercise athletes ionized magnesium variation blood
study of hlx10, trastuzumab and chemotherapy in first-line treatment of her2-positive recurrent/metastatic gastric cancer

Conditions: HER2-positive Gastric Cancer

Summary: investigators assessed the effectiveness of hlx10, trastuzumab and chemotherapy in first-line treatment of her2-positive recurrent/metastatic gastric cancer


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically proven metastatic or locally advanced her2-positive gastric cancer 2. documented disease progression after receiving prior line of trastuzumab-containing chemotherapy for gastric cancer 3. able and willing to give written informed consent and has signed the informed consent form (icf), prior to performance of any trial activities. 4. eligible male and female subjects aged ≥18 years. 5. has measurable disease as determined by recist 1.1. 6. eastern cooperative oncology group (ecog) performance status of 0 to 1. 7. has baseline left ventricular ejection fraction (lvef) ≥ 55%. 8. adequate organ function as demonstrated by laboratory test results within 14 days prior to first dose of study treatment. 9. have urinary protein that is \<2 on dipstick or routine urinalysis. 10. female subject of childbearing potential should have a negative urine or serum pregnancy within 72 hours prior to first dose of study treatment. 11. female subjects of childbearing potential and male subjects should be willing to use methods of birth control for the course of the study and up to 120 days after the last dose of study treatment. exclusion criteria: 1. received prior anticancer treatment with targeted agents, chemotherapy, or radiotherapy within 14 days, with monoclonal antibodies within 28 days, has previously received treatment with ramucirumab, or has participated in another clinical trial within 14 days prior to start of study treatment. 2. has experienced any grade 3-4 gastrointestinal bleeding within 3 months prior to treatment. 3. has experienced any arterial thromboembolic events, including but not limited to myocardial infarction, transient ischemic attack, cerebrovascular accident, or unstable angina, within 3 months prior to treatment. 4. has history of severe thromboembolism, including deep vein thrombosis and pulmonary embolism within 6 months prior to treatment. 5. has an active or ongoing infection, symptomatic congestive heart failure, （6）uncontrolled angina pectoris, symptomatic or poorly controlled arrhythmia, uncontrolled thrombotic or hemorrhagic disorder, or any other serious uncontrolled medical disorders in the opinion of the investigator. （7）has ongoing or active psychiatric illness or social situation that would limit compliance with study requirements. （8）has known active central nervous system (cns) metastases and/or carcinomatous meningitis. （9）has evidence of active, non-infectious pneumonitis. （10）have an elective or a planned major surgery during the course of the trial or has undergone major surgery within 4 weeks prior to enrollment.
exploratory trial of a group psychological intervention for postnatal depression in british mother's of south asian origin

Conditions: Depression, Postpartum; Postnatal Depression in British South Asian Women

Summary: this study is an exploratory randomized controlled trial (rct) of a group psychological intervention for postnatal depression in british mother's of south asian origin. the aim is to evaluate the efficacy of a group psychological intervention (php) based on the principles of cognitive behaviour therapy in treating depression in postpartum women. the hypothesis is that depressed british women of south asian origin receiving the group intervention will show significant improvements in terms of severity of depression as compared to the treatment as usual (tau) control group.


Eligibility criteria:
inclusion criteria: * self-ascribed british women of south asian origin as defined by uk office of -national statistics, * over the age of 16 years * living with their babies, * who meet the criteria for icd-10 depression exclusion criteria: * women with diagnosed physical or learning disability, * post-partum or other psychosis, * severely depressed * actively suicidal.

Keywords: culturally adapted group psychological intervention british south asian women cbt
effect of pressure support ventilation during anesthetic emergence on postoperative atelectasis in infant

Conditions: Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery

Summary: atelectasis occurs in patients of all ages who receive mechanical ventilation under general anesthesia, and although fatal cases are rare, it is known as a cause of postoperative hypoxia or fever. in pediatric patients, it has a particularly high incidence of 68-100%, and the incidence is inversely proportional to age. pediatric patients,compared to adults, have a small capacity for functional residual capacity while a high metabolic demand, making them fundamentally vulnerable to hypoxia. increased atelectasis during anesthesia causes hypoxia not only during anesthesia but also during recovery after anesthesia. therefore, it is important to establish and apply a strategy to minimize the occurrence of atelectasis during mechanical ventilation under general anesthesia in pediatric patients. the aim of this study is to investigate whether pressure support ventilation at emergence period could reduce the incidence of postoperative atelectasis in infants undergoing surgery under general anesthesia.


Eligibility criteria:
inclusion criteria: 1. infant patients aged 0 day to 13 month 2. american society of anesthesiologists (asa) classification 1\~2 who are scheduled for elective surgery under general anesthesia exclusion criteria: 1. patients with symptomatic bronchopulmonary dysplasia 2. patients with uncorrected congenital heart or pulmonary disease 3. hemodynamically unstable requiring preoperative vasopressor administration 4. fever (\>37.5°) or uri symptoms on the day of surgery
emtricitabine plus adefovir dipivoxil for naive chinese hbv related cirrhosis patients

Conditions: Hepatitis B, Chronic; Fibrosis

Summary: this study evaluates generic emtricitabine(ftc) plus adefovir dipivoxil in chinese naive hbv related cirrhosis patients. patients were divided into 2 groups: compensated hbv related cirrhosis patients and decompensated hbv related cirrhosis patients.

generic emtricitabine(ftc) has been approved for treatment of naive chronic hepatitis b(chb) patients in china. yet data are limited for this agent plus adefovir dipivoxil in cirrhosis patients. the investigators design this trial to test the effect of ftc plus adefovir dipivoxil in chinese naive compensated and decompensated hbv related cirrhosis patients.

Eligibility criteria:
inclusion criteria: * dignosed cirrhosis patients * hbsag positive for more than 6 months * hbv dna detectable * nucleoside/nucleotide naive patients exclusion criteria: * diagnosed hcc with afp and ultrasound, ct or mri * creatine \>130μmol/l or ccr \< 70ml/min * hemoglobin \<100g/l * coinfected with hav,hev,hcv,hdv or hiv * ana \> 1:100 * uncontrolled cardiovascular diseases, kidney diseases,lung diseases, neurological diseases, digestive diseases,metabolic disorders, immune-compromised diseases or cancer; * drug abuse or alcohol addiction * previous history of taking agents of lamivudine, adefovir, tenofovir entecavir or telbivudine * long-term use of immunosuppressor or immunomodulator 6 months before enrollment to this trial * underwent liver transplantation or liver transplantation in schedule * allergic to nucleoside or nucleotide analogues * pregnancy or in breastfeeding

Keywords: hepatitis b virus cirrhosis emtricitabine adefovir dipivoxil
hormonal levels in men with major depressive disorder

Conditions: Depression

Summary: subjects will be 1000 men meeting the following inclusion criteria: 1) male, age 18-65 years; 2) meeting dsm-iv criteria for major depressive disorder within the past one year, with a ham-d score \>12. subjects will be excluded if they exhibit 1) a substance abuse or dependence disorder within the past year; 2) current psychotic symptoms; or 3) a history of bipolar disorder. procedure after informed consent, eligible patients will have blood drawn for serum hormone levels; cortisol, dhea-s and testosterone or they will provide a salivary sample for measurement of hormone levels. we will also test hormone level form 1000 healthy males (from blood or saliva) at the same age for comparison.


Eligibility criteria:
inclusion criteria: * male * major depression disorder * 18-65

Keywords: male, mdd, testosterone, dhea-s,cortisol male 18-65 major depression
study on laparoscopic operation for perforated appendicitis

Conditions: Perforated Appendicitis

Summary: the purpose of this study is to conduct a prospective observational study for the open approach and laparoscopic approach for perforated appendicitis. it is also designed to investigate if carbon dioxide pneumoperitoneum will have unwanted effect when treating perforated appendicitis with laparoscopic operation.

the role of laparoscopic appendectomy (la) for perforated appendicitis is under investigation. according to the results of a previous retrospective study conducted in far-eastern memorial hospital comparing the clinical outcomes between perforated appendicitis patients treated by laparoscopic and open approach showed favored clinical outcomes for la. same as a few studies indicated that laparoscopic appendectomy is a safe and effective procedure for treating patients with perforated appendicitis in terms of hospital stay and wound complications. one the other hand, some authors still concern about the adverse effects of laparoscopy for ruptured appendicitis patients in terms of longer operation time and increased rates of postoperative abscess formation. we hypothesize that prolonged co2 pneumoperitoneum will produce transient mesenteric ischemic and reperfusion injury when co2 disinflation, and the free radicals and oxidative proteins provoked by reperfusion injury are responsible for the adverse reaction of la. the objective of this prospective non-randomized controlled study is to examine the safety and efficacy of laparoscopic appendectomy and compare its outcome with that of the conventional approach for perforated appendicitis patients, with special emphasis on postoperative complication and oxidative stress resulted from pneumoperitoneum..

Eligibility criteria:
inclusion criteria: * all patients admitted at the emergency station of our hospital expressing pain other than the right lower abdominal quadrant. * the results of a clinical examination favored the diagnosis of perforated acute appendicitis, and the result of abdominal computed tomography revealed signs of acute appendicitis and intra-abdominal fluid accumulation. * patients were accepted to our study only if perforated appendicitis remained as the most likely diagnosis of their condition and if they were between 12 from 80 years old with informed consent. exclusion criteria: * age less than 12 years * older than 80 years * perforated appendicitis was not revealed by pathologic investigation * diverticulitis being diagnosed during surgery * pelvic inflammatory disease or other gynecologic disease found during laparoscopic examination or diagnosed before operation * the patient declining to enroll in this study

Keywords: perforated appendicitis laparoscopic appendectomy open appendectomy cytokines free radicals oxidized proteins
alternative treatment of deep carious lesions based on biological evidences

Conditions: Caries, Dental

Summary: the purpose of this study is to evaluate the success rate of alternative treatment of deep carious lesions in asymptomatic primary teeth with no clinical nor radiographic signs of pulpal inflammation. the treatment includes leaving a thin layer of caries that is present near the pulp chamber and includes liner placement and tooth sealing. this alternative treatment is to be compared with the treatment provided today to these teeth, which includes complete removal of caries and probably includes pulpotomy and wide preparation of the tooth. the study also evaluates the cost-effectiveness of both methods of treatment of deep carious lesions.

the treatment provided today for deep carious lesions in deciduous teeth is complete removal of the soft caries, that can lead to a wide preparation and need of tooth pulpotomy if the caries reaches to the pulp chamber, even if the tooth is asymptomatic and shows no signs of pulpal inflammation (neither clinically nor radiographically). according to a number of recent evidence based researches, and only in selected cases, dentists were able to preserve the vitality of the pulp without complete removal of the caries present near the pulp chamber. a thin layer of caries near the pulp chamber is left, and a liner is placed (conservative treatment). the carious process is stopped when the tooth is sealed, and thus the tooth is saved without engaging with pulpotomy and wide preparation of the tooth. the purpose of this study is to evaluate the success rate of the conservative treatment of deep carious lesions versus the treatment provided today that includes complete removal of caries and probably includes pulpotomy and wide preparation of the tooth. the study also evaluates the cost-effectiveness of both methods of treatment of deep carious lesions.

Eligibility criteria:
inclusion criteria: * healthy children * patient's age is 5-8 years old at the time of the treatment * primary molars presenting with deep carious lesions * carious lesion reaching the inner half of the dentin,with absence of periapical or interradicular alterations as detected by radiographic examination. * absence of spontaneous pain exclusion criteria: * subjects that are not asa i * lack of cooperation * clinical or radiographic signs of pathology

Keywords: primary tooth caries, dental alternative treatment
the relationship between personality traits and perioperative anesthetic drug consumption

Conditions: Anesthesia; Infertility

Summary: in this study, we aimed to examine the association between personality traits and amount of anesthetic drug consumption,of the patients who will receive sedoanalgesia for the oocyte retrieval procedure. as well as determining the anxiety scores in the preoperative period, the time to reach the desired sedation level, hemodynamic parameters in the perioperative period, peripheral oxygen saturation, etco2 value, postoperative pain, postanesthetic recovery, analgesic drug need, unconscious movement, and patient satisfaction.

different personality traits, anxiety disorders, depression, and somatoform disorders are frequently encountered in women with infertility problems. although there are many studies evaluating the relationship of anxiety with variables such as hemodynamic parameters, need for anesthetic medication, recovery times, postoperative pain and analgesic requirements, the relationship between personality traits and these variables has not been investigated. in our study, considering that the anesthesia needs of these patients with a stressful negative factor such as infertility may be at different levels, preoperative evaluation of the patients with a personality questionnaire will provide better perioperative management, a better quality recovery and possibly a higher quality oocyte aspiration. in this study, it was aimed to investigate the amount of anesthetic agent consumption, recovery times, postoperative pain scores, analgesic requirements, involuntary movement, time to reach sufficient sedation depth, and patient satisfaction of patients thought to have sedation. all patients will fill out personality belief scale-short form (pbq-s1) and beck anxiety scale one day before the procedure and they will be registered.

Eligibility criteria:
inclusion criteria: * 18- 50 year-old elective patients who signed the informed consent form from asa i-ii patients scheduled for oocyte retrieval. * patients with sufficient education and mental capacity to complete in assessment scales and questionnaires. * patients without neurological disorders, psychological illnesses, or drug or alcohol abuse * patients without stimulant drug and alcohol consumption * absence of significant cardiovascular, respiratory, kidney or liver disease. exclusion criteria: * psychiatric or neurological disorder * psychiatric drug use or alcohol consumption * pregnancy * presence of severe cardiac, hepatic or cerebrovascular disease * history of allergy to local anesthetics or systemic opioids * history of chronic pain * patients who are unable to evaluate scales and questionnaires

Keywords: personality traits anesthetic drug consumption anxiety acute pain