Kornimate/medical-research-clean huggingface dataset:
effect of liraglutide on the beta-cell responsiveness in subjects with type 2 diabetes compared to a healthy control group

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in the united states of america (usa). the aim of this trial is to assess the effect of nnc 90-1170 on beta-cell responsiveness to increasing blood glucose concentrations in subjects with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes, either newly diagnosed with at least 2 months of diet or on oad monotherapy for at least 3 months * body mass index (bmi): 24-35 kg/m\^2 inclusive exclusion criteria: * subjects with type 2 diabetes * receipt of any investigational drug within three months prior to this trial * recurrent severe hypoglycemia as judged by the investigator * cardiac disease * use of any drug (except an oad (oral anti-diabetic drug)) that in the investigator's opinion could interfere with the blood glucose level * haemoglobin maximum 10 g/l * hba1c above 12% * loss of more than 400 ml blood during the 3 months prior to trial start * healthy subjects * receipt of any investigational drug within 3 months prior to this trial * clinically relevant cardiac disease or any clinically significant abnormal ecg (electrocardiogram) * use of any drug that in the investigator's opinion could interfere with the blood glucose level * haemoglobin max. 10 g/l * hba1c at least 6%
efficacy of twinkle eyez supplementation in improving ocular health and immunity

Conditions: Dry Eye Disease; Immunity

Summary: this is a randomised, double-blind, placebo-controlled study that recruited 110 participants. the objectives of this study are to determine the dietary intake levels of lutein and zeaxanthin among precipitants. in additionally, this study also aimed to determine the efficacy of twinkle eyez supplementation in improving ocular health and immunity. the participant are required to take one sachet of twinkle eyez supplements or placebo for 20 days. the outcomes were assessed by food frequency questionnaire (ffq), ocular surface disease index (osdi), the immune status questionnaire (isq), and the visual analogue scale (vas).


Eligibility criteria:
inclusion criteria: * presence of dry eye symptoms * age 18 years or older * ability to comprehend the study protocol and information provided by the investigators * provision of informed consent. exclusion criteria: * ongoing medical treatment for ocular diseases or conditions * use of certain medications, including hormone replacement therapy, antidepressants, and treatments for high blood pressure, acne, birth control, and parkinson's disease * history of eye surgery within the past three months * pregnancy or lactation

Keywords: lutein zeaxanthin elderberry ocular health immunity
clinical deterioration in cerebral venous thrombosis: a predictive study

Conditions: Cerebral Venous Thrombosis

Summary: the objective of this retrospective, prospective, multicenter cohort study is to determine the risk factors for deterioration of cvt patients after admission and establish a scoring model for risk stratification of patients. this study included two stages, the first stage was to enroll cvt patients from a single center from 2017 to 2022 for modeling, and the second stage was to enroll cvt patients from three centers in 2023 for external validation


Eligibility criteria:
inclusion criteria: * age≥ 18 years old * patients were diagnosed with cerebral venous thrombosis (cvt) through imaging techniques such as computed tomography venography (ctv), magnetic resonance venography (mrv), or digital subtraction angiography (dsa) * the diagnostic algorithm for cvt conformed to the current guideline criteria exclusion criteria: * patients who had performed endovascular treatment (evt) or decompressive craniectomy (dc) before admission and those whose primary treatment was evt or dc rather than conservative treatment after admission * patients with severe hepatic or renal insufficiency * patients with intracranial tumors * patients with other cerebrovascular diseases
brief internet-based acceptance and commitment therapy intervention for parents in the postpartum

Conditions: Postpartum Depression

Summary: it is common for parents in the postpartum period (the first twelve months following childbirth) to experience psychological difficulties, particularly low mood. acceptance and commitment therapy (act) is an evidence-based intervention that aims to cultivate psychological flexibility; the ability to stay in contact with the present moment regardless of unpleasant thoughts, feelings and bodily sensations, while choosing one's behaviours based on values. acceptance and commitment therapy (act) is effective in reducing depression in the general population, including brief act interventions. however, the effectiveness of act interventions in the postpartum period is not yet fully established. this study aims to investigate the feasibility (recruitment source, rate and attrition rate), acceptability (usability, usefulness and satisfaction) and the potential effectiveness (to inform the required sample size for a fully powered randomised control trial) of a four week internet-based act intervention for postpartum parents on depression.


Eligibility criteria:
inclusion criteria: * aged over 18 years * have a child under 12 months * scoring 10 or above on the edinburgh postnatal depression scale * access to the internet through a computer, tablet or phone * fluency in english exclusion criteria: * none
chemotherapy resistance in osteogenic sarcoma and other solid tumors

Conditions: Osteosarcoma

Summary: the purpose of this study is to investigate tumors in the laboratory to determine how and why they respond, or fail to respond to different drug therapies. this study will also investigate why high pressure develops within tumors and how this affects how well drugs work. we will also take blood samples before and/or after your procedure to measure biochemical factors that may help us predict the behavior of osteogenic sarcoma and other solid tumors.

when tumor tissue known or presumed to be a primary or secondary bone cancer or solid tumor with known elevated intra-tumoral pressure such as retinoblastoma is being removed or has been removed for diagnostic or therapeutic reasons a small sample of it will be obtained for this study. the tumor samples will be used to study in vitro, determinants of chemotherapy resistance and oncogenesis. these determinants will be correlated with histologic response to preoperative chemotherapy and clinical outcome (event free survival). in addition, blood samples (20ml) may be obtained before or after the procedure.

Eligibility criteria:
inclusion criteria: * all patients with a presumed or known diagnosis of a primary or secondary bone cancer or other solid tumor who are having or have had a biopsy or surgery to remove tumor for diagnostic or therapeutic reasons. no tumors will be obtained solely for research purposes. * all adult patients (\> or = to 18 yrs.) will have given written informed consent. * all minor patients (\<18 yrs.) will have given assent to the best of their ability to understand, and their parent or guardian will have given written informed consent exclusion criteria: * n/a

Keywords: bone
effect of sonication on periprosthetic joint infection treatment strategy.

Conditions: Prosthesis-Related Infections; Hip Prosthesis Infection; Joint Infection; Biofilm

Summary: it is not known in the literature how much sonication affects the patient's treatment. another important issue is that the place of this method in diagnosis is not clear. the aim of this study is to contribute to the literature on this issue and to determine the sensitivity and specificity of sonication prospectively using the new definition and effect of sonication on the treatment strategy in terms of infection in patients with pji.

total knee and hip arthroplasties are successful surgical procedures that are widely applied all over the world and provide high patient satisfaction and increased quality of life. periprosthetic joint infection (pji), is a serious complication that negatively affects the targeted result, decreases patient satisfaction, and increases morbidity and mortality after total joint replacement. another important issue, the previous infection is the most important reason for the failure of surgery in revision arthroplasty. it is known that the success of pji treatment seriously can be affected by the type of microorganism and antibiotic sensitivity. therefore, microbiological examination methods are always of interest, and one of them is the sonication method.

Eligibility criteria:
inclusion criteria: * all patients scheduled for revision arthroplasty (aseptic revision, septic revision, instability, and periprosthetic fracture) exclusion criteria: * who do not accept to participate in research * insufficient data for new definition criteria * acute periprosthetic infections * patients with systemic inflammatory disease

Keywords: total knee arthroplasty complication total hip arthroplasty periprosthetic infection revision arthroplasty sonication biofilm
social connections and late life suicide

Conditions: Depression; Suicidal Ideation

Summary: with the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social connectedness. the investigators propose to examine whether a manualized intervention that targets connectedness--engage--increases connectedness in older adults who report clinically significant depression and disconnectedness-operationalized as feeling lonely and/or like a burden on others. the investigators propose a randomized controlled trial comparing the engage intervention with care-as-usual (cau), using n=100 primary care patients aged ≥ 60 years who report social disconnectedness (i.e., loneliness or burdensomeness) and either minor or major depression. at baseline, 3-week, 6-week and 10-week assessments, subjects will report on social connectedness, depression, and suicide risk. the investigators hypothesize that those subjects assigned to engage will report greater increases in connectedness-measured as greater belongingness and lower burdensomeness-compared to cau; that engage will produce greater reductions in depression and suicide ideation than cau; and that changes in depression will be accounted for changes in social connectedness.


Eligibility criteria:
inclusion criteria: * age ≥ 60 yrs; * english speaking; * reside in the community; * endorse social disconnectedness, as measured by feeling lonely and/or like a burden on others; * meet criteria for minor or major depression. exclusion criteria: * imminent risk for suicide; * active psychosis; * significantly impaired cognitive functioning (i.e., moca \<23); * active substance abuse in the last year (audit score of 5 or more); * hearing loss that precludes comfortable communication; * residence in a long-term care facility.
correlating time-lapse parameters with acgh testing in ivf treatment (acgh study)

Conditions: Infertility

Summary: the purpose of this research study protocol is to collect imaging data on embryos followed to blastocyst stage (day 5-6) and correlate eeva parameters with array - comparative genomic hybridization (acgh) results and ongoing pregnancy rates.

the present study was designed to determine if there is a correlation between the eeva system parameters and acgh testing results. embryos will be selected for transfer based on acgh results and morphology. the clinical site will have no access to the eeva analysis at the time of the transfer.

Eligibility criteria:
inclusion criteria: * subject is ≤43 years of age. * women undergoing ivf treatment with planned acgh testing using her own eggs or donor eggs. * antral follicle count ≥ 6 at time of cycle start * baseline (day 2-3 of cycling) fsh ≤ 15 miu/ml * antimüllerian hormone level ≥ 0.5 ng/ml * fertilization using only ejaculated sperm (fresh or frozen) - no surgically retrieved sperm. * willing to have all 2pn embryos monitored by eeva * not previously enrolled in this study. * willing to comply with study protocol and procedures and able to speak english. * willing to provide written informed consent. exclusion criteria: * bmi ≥ 40 * prior ivf cycle with \< 4 x 2pn * planned day 3 assisted hatching

Keywords: in vitro fertilization assisted reproduction techniques noninvasive imaging of embryos time lapse imaging of embryos traditional morphological grading of embryos prediction of blastocysts infertility preimplantation genetic diagnosis array-comparative genomic hybridization
inflammation following mepolizumab and oral corticosteroids in asthma

Conditions: Asthma

Summary: the aim of the project is to study the persistence of inflammation after addition of an interleukin-5 (il-5) blocker in severe eosinophilic asthma as a study of untreated pathways in these patients.

mepolizumab, a humanized monoclonal antibody (mab) antagonizes il-5 and through a selective inhibition of eosinophilic inflammation, reduces the number of eosinophils in sputum and blood, leading to a reduction in asthma exacerbations and a need for systemic glucocorticoids. once this therapy has been initiated for severe eosinophilic asthma, the additional role of oral corticosteroids is questionable as their main target is reduction of eosinophils and hence responsiveness to oral corticosteroids in patients in a stable state of asthma may reduce. using two weeks of high dose prednisolone versus placebo in a crossover design after 12 weeks of mepolizumab therapy will allow an understanding of the pathways that remain steroid responsive following il-5 suppression. this is an exploratory study with no single primary end point. the objective of the study is to assess the change in airway inflammation following oral corticosteroids versus placebo and the airway inflammation while on mepolizumab in stable state of asthma. note: mepolizumab is not an intervention in this study; it is initiated as part of usual nhs care.

Eligibility criteria:
inclusion criteria: * age ≥ 18 and ≤ 80 years at consent. * able and willing to provide written informed consent and to comply with the study protocol. * severe asthma diagnosis confirmed after assessment by an asthma specialist. * suitable for mepolizumab as per nice/smc clinical guidelines. exclusion criteria: * maintenance oral corticosteroid treatment within the past four weeks. * acute exacerbation requiring oral corticosteroids in the four weeks prior to consent. * other clinically significant medical disease or uncontrolled concomitant disease despite treatment that is likely, in the opinion of the investigator, to require a change in therapy or impact the ability to participate in the study or be significantly worsened by oral corticosteroids. * history of current alcohol, drug, or chemical abuse or past abuse that would impair or risk the subject's full participation in the study, in the opinion of the investigator. * treatment with an investigational agent within 30 days of visit 1 (or five half-lives of the investigational agent, whichever is longer). * women of child-bearing potential who are pregnant, lactating, planning pregnancy during the study period or are unwilling to use a highly effective form of contraception. * known hypersensitivity to prednisolone or its excipients. * previous psychiatric adverse reactions to steroid therapy in the past. * concomitant medication with systemic anti-fungals such as ketoconazole, retinoids, tetracycline, other systemic immunosuppressants e.g. ciclosporin, azathioprine, mycophenolate and live vaccines during the crossover trial.

Keywords: severe asthma mepolizumab il5 steroid resistance eosinophilic asthma type 2 inflammation
pediatric early rehabilitation in acute lymphoblastic leukemia

Conditions: Neoplasms; Pediatric Cancer; Physical Therapy; Telemedicine

Summary: the purpose of this study is to determine the feasibility and acceptability of a hybrid in-person and virtual individualized physiotherapy program using the healthy eating and active living (heal-me) online platform for children diagnosed with acute lymphoblastic leukemia. we would like to know if this type of hybrid program delivery model is feasible, and if children and their parents are willing and able to participate in the program. we will do this by recording how many, and what type of physiotherapy sessions (in-person or virtual) are completed, what resources offered on the platform are accessed, and how many children complete the assessments.

acute lymphoblastic leukemia is the most common childhood cancer, representing approximately 25% of cancers in children. improvements in survival rates have resulted in an increased number of children living with neuromuscular and musculoskeletal side effects of cancer treatments-effects that may persist or worsen over the long-term into adulthood. the overall goal of the study is to determine the feasibility of a tailored physiotherapy (pt) program using an online platform for children diagnosed with acute lymphoblastic leukemia. a quasi-experimental, single group, before and after intervention feasibility study will be conducted, comprising a convenience sample of a minimum of 10 children between 4 and 17 years of age undergoing or having completed chemotherapy treatment for acute lymphoblastic leukemia. children will participate in a hybrid 12-week pt program delivered in-person at the stollery children's hospital with educational components provided virtually via the healthy eating and active living web-based platform. children will participate in six physical therapy sessions over a period of three months and will have the option to choose the mode of delivery: 1:1 in-person, 1:1 virtual, group virtual, or combination of all. the main outcome will be feasibility, as determined by recruitment and retention rates, completion rates of measurements, adherence to sessions, and safety and acceptability.

Eligibility criteria:
inclusion criteria: 1. children diagnosed with acute lymphoblastic leukemia aged between 4 and 17 years (at time of diagnosis) and their mother, father, or primary carer; 2. undergoing or completed cancer treatment as established by the children's oncology group; 3. access to the internet through a home computer or tablet; 4. patient or caregiver is able to speak and comprehend english; and 5. the child is approved by their oncologist to participate in the program. exclusion criteria: 1. children with a history of a neurodevelopmental or genetic disorder (i.e., down syndrome, autism, seizure disorder) prior to the cancer diagnosis; and 2. children with a concurrent condition (illness, disease, psychiatric disorder), as determined by oncologist or physiotherapist, that would compromise study participation or interpretation of study results.
effects of costovertebral joint mobilization on respiratory function in asthmatic patients

Conditions: Asthmatic

Summary: the aim of this randomized controlled trial is to determine the effectiveness of costovertebral joint mobilization on lung function in asthmatics. by targeting the thoracic region, costovertebral mobilization can play a valuable role in enhancing respiratory function and improving the overall well-being of individuals with respiratory conditions.

costovertebral joint mobilization can help to improve this by increasing the mobility of the ribs and thoracic spine, which can help to expand the chest and improve lung function. additionally, costovertebral joint mobilization can help to reduce muscle tension in the chest and upper back, which can also contribute to improved respiratory function. this is because tense or tight muscles can restrict the movement of the rib cage, limiting the ability of the lungs to expand and contract. mobilization are performed in three positions, sitting, supine lying and side lying with arm abducted of the side to be mobilized. the improvement by regular physical training of breathing technique and chest wall mechanics may be explained by mobilization of the costovertebral articulations.

Eligibility criteria:
inclusion criteria: * force expiratory volume 1/force vital capacity ratio less than 0.7 * mild asthma (force expiratory volume 1 over 70% predicted) * chest tightness (inspiratory muscle tightness) * altered dyspnea index. exclusion criteria: * presence of any underlying lung condition other than asthma. * significant cardiovascular or musculoskeletal disease that may compromise the participant's capacity to participate in physical activity; * active cancer. * uncontrolled hypertension or diabetes.

Keywords: costovertebral joint mobilization chest tightness asthma respiratory function
high-intensity-interval-training in geriatric rehabilitation - a feasibility study

Conditions: Rehabilitation; Post-Operative Condition; Deconditioning After Acute Hospital; Oncology

Summary: study with patients (40-60 participants) above the age of 65. there will be a comparison of regular training on ergometer (10 trainings within 2 weeks, 40 min each) to high intensity interval training on ergometer (6 trainings within 2 weeks, 25 min each). at the beginning and at the end will be a spiroergometer to measure the individual limits and vo2max, which will be compared amongst the two groups. to receive a subjective feedback, there will be a series of questionnaires at the beginning, after one week and at the end. the goal of this study is to get more information about whether a hii-training is feasible with elderly patients and whether they can profit form it.


Eligibility criteria:
inclusion criteria: * cardiopulmonal resilient * able to sit on a ergometer * knowledge of german written and spoken exclusion criteria: * severe cardiopulmonary restriction (lvef \<30%, conduction abnormalities from av block iib or higher) * absolute cardiopulmonary contraindications (acute coronary syndrome, unstable ap -\> not capable of rehabilitation), uncompensated heart failure (dyspnea at rest, orthopnea, severe edema) * no ischemic events (cardiac, cerebral, peripheral) within the last 3 months * severe pneumatological underlying disease: copd gold 3 and higher or status after exacerbation within the last 2 weeks, asthma grade 4 * dyalisis reliant * severe psychiatric disorder (severe psychosis, severe depression) * distinct dementia