Kornimate/medical-research-clean huggingface dataset:
vaginal fluid collection for detection of endometrial cancer

Conditions: Endometrial Cancer

Summary: the primary objective of this study is to obtain de-identified vaginal fluid specimens from participants with an endometrial tissue biopsy-based histopathological diagnosis of endometrial cancer (ec), endometrial hyperplasia (aeh) with atypia or endometrial intraepithelial neoplasia (ein). the samples will be used for the purpose of research and development of a new molecular diagnostic test for the detection of ec, aeh and ein.

for participants providing written informed consent to participate in the study, samples of vaginal fluid will be obtained by the principal investigator (pi) during a pelvic examination. all vaginal fluid samples will be collected ≥7 days after the endometrial biopsy and prior to initiating any therapeutic interventions including surgery, chemotherapy, radiation or hormonal therapy pis will be provided with multiple, individually packaged copan enat® sterile sample collection kits including a swab and a transport tube containing a stabilizer and preservative medium as well as a pre-addressed shipping container and single-use tubes of sterile saline solution after vaginal fluid sample collection, the swab will be inserted into the tube for storage and subsequent shipping to the sponsor's designated laboratory. the samples can be stored at ambient temperature and should be shipped to the designated laboratory within 24 hours of collection. site(s) will provide the sponsor with de-identified endometrial biopsy histopathology report and post-surgery histopathology report (if any) confirming the histopathological diagnosis of ec, aeh or ein. the final diagnosis will be based on the most severe clinical histopathology (at diagnostic endometrial sampling or surgery.)

Eligibility criteria:
inclusion criteria: 1. women ≥18 years of age. 2. women with endometrial tissue biopsy-based histopathological diagnosis of ec (any histology, including uterine carcinosarcoma), aeh or ein. 3. women whose planned surgical intervention (if any) includes hysterectomy, d\&c, or hysteroscopic resection. 4. participant understands the study procedures and can provide informed consent to participate in the study and authorization for release of relevant protected health information to the study investigator. - exclusion criteria: 1. patient with recurrent and/or previously treated ec. 2. receipt of preoperative neoadjuvant chemotherapy or radiotherapy for current ec diagnosis prior to study enrollment. 3. prior hysterectomy. 4. current known pregnancy diagnosis. 5. prior or current biopsy and histopathology-proven cervical cancer. 6. the presence of concomitant biopsy and histopathology-proven cervical dysplasia. 7. any prior pelvic or vaginal radiotherapy. 8. any current or prior cancer diagnosis (except basal cell or squamous cell skin cancer, non-gyn) within the past 5 years. 9. chemotherapy within the past 5 years. 10. prior intervention to treat, or surgery with intent to completely remove, the target pathology for the current diagnosis during the current episode.
observational study of eating behavior in patients with diabetes mellitus and obesity undergoing liver transplantation

Conditions: Liver Transplant

Summary: the study aims to evaluate the presence of eating disorders, which consists of having an altered relationship with food, in patients on the list or already undergoing liver transplantation.

the study involves the enrollment of at least 100 patients, currently followed for the treatment of severe organ failure, on the list or already undergoing liver transplantation and referred for a dietetic visit.

Eligibility criteria:
inclusion criteria: * signature of written informed consent to participate in the observational study, either by the participant or legal guardian * age \> 18 years * diagnosis of type 2 diabetes mellitus and/or overweight or obesity, (bmi \> 25) * be listed for olt or have already been submitted to olt exclusion criteria: * -previous diagnosis of psychiatric illness;
phase 3 study of tramadol hydrochloride/acetaminophen sr tab. & tramadol hydrochloride/acetaminophen tab. in acute toothache patients after teeth extraction surgery

Conditions: Acute Toothache Patients Above Moderate Pain After Teeth Extraction Surgery

Summary: a randomized, double-blind, active-controlled, parallel, multicenter phase 3 study of tramadol hydrochloride/acetaminophen sr tab. \& tramadol hydrochloride/acetaminophen tab. in acute toothache patients above moderate pain after teeth extraction surgery.


Eligibility criteria:
inclusion criteria: 1. adult males/females aged over 20 years 2. patients with over 2 impacted wisdom teeth in the upper and lower jaws 3. pain vas value over 50 mm evaluated as 100mm vas 4. subjects who voluntarily or legal guardian agreed with written consent exclusion criteria: 1. patients with severe heart disease, uncontrol hypertension, diabetes 2. patients who had taken a long period nsaid (eg. celecoxib, rofecoxib naproxen etc) within 3 days from the screening point 3. patients who had taken short-time anesthetic drugs and analgesics within 12 hours from the screening point (except short-time anesthetics before or during surgery) 4. patients with aspirin asthma(asthma seizure caused by nsaids) or medical history 5. patients with severe respiratory depression

Keywords: acute toothache wontran wontran sr tab. tramadol hydrochloride/acetaminophen
exploratory study for the validity of ququ scale

Conditions: Alzheimer Dementia

Summary: examine the construct validity, the group discriminant ability, and the inter-rater reliability of a novel dementia rating scale (ququ scale: quick question scale) candidate for the evaluation of patients with alzheimer dementia (ad)


Eligibility criteria:
inclusion criteria: 1. alzheimer dementia (ad) patients and patients with cognitive concern without dementia 2. written informed consent by each subject and/or a legal representative, and study informant. if the doctor decides that the patient has no trouble in understanding this study, the written informed consent of a legal representative may be exempted. if not, this study needs a written informed consent by a legal representative and the patient except the case where the consent is hardly obtained due to the progression of the disease. exclusion criteria: 1. patients with other types of dementia (e.g. vascular dementia, levy body dementia, frontotemporal dementia) 2. patients with other diseases which cause secondary dementia prior to alzheimer dementia (ad) 3. patients with other severe neurological disease or psychiatric disorder without alzheimer dementia (ad) 4. patients with other medical conditions where the investigators determine that it is inappropriate for the subject of this study (e.g. inappropriate for the evaluation of dementia rating scale)

Keywords: alzheimer dementia, ad patients cognitive
additional effect of pain neuroscience education to spinal manipulative therapy in chronic low back pain

Conditions: Low Back Pain

Summary: objectives: the primary objective will be to investigate the additional effect (immediate and after one-month follow up) of pain neuroscience education (pne) to spinal manipulative therapy (smt) on primary outcomes of pain intensity and disability in patients with chronic nonspecific low back pain (clbp).

design: this study will be a blinded randomized controlled clinical trial. participants: one hundred and four participants with clbp (18 and 55 years) both genders. interventions: individuals included will be randomized into two possible treatment arms: pne+smt or smt alone. each treatment will last for 8 sessions. the group submitted to pne+smt will received in the first two initial sessions an individual face-to-face pne program of 40 minutes.main outcome measures: pain intensity and low back pain-related disability will be adopted as primary outcomes and as secondary outcomes we will assess fear-avoidance, pain self-efficacy and global perceived effect of improvement. the outcomes will be assessed on three occasions: pre-intervention, immediately after 8 sessions of intervention and after one-month follow-up period. all statistical analysis will be conducted following the principles of intention to treat, and the effects of treatment will be calculated using linear mixed models. discussion: this study will help to better understand if pne -a psychosocial cognitive intervention- will add significant effect (immediate and at follow-up) to a movement therapy protocol based on manual therapy.

Eligibility criteria:
inclusion criteria: 1. who present chronic, non-specific, continuous and recurrent low back pain lasting at least three months and 2. contemplate at least three of the following criteria: 1-hip internal rotation with\> 35 °; 2-lumbar spine hypomobility; 3-absence of distal knee symptoms and 4-point fabq work score 19. exclusion criteria: 1. pregnant women; 2. red flags (neoplasia, vertebral column fracture, vertebral osteomyelitis, infection or equine tail syndrome, rheumatic diseases, diseases that compromise cognition); 3. disc herniation; 4. women in the luteal phase will be rescheduled; 5. patients with cognitive deficits evaluated according to the mini mental state examination with score less than or equal to 24 points or 22 points (low education level) and 6. previous physical therapy for low back in the past year or submitted to any health/pain education strategy. patients will be instructed to not use pain relief medications during the intervention period of this trial and if any medication be used, participants will be encouraged to report.

Keywords: chronic low back pain pain neuroscience education spinal manipulative techniques psychosocial factors
study of immunotherapy in combination with ublituximab and umbralisib in patients with relapsed-refractory cll or richter's transformation

Conditions: Chronic Lymphocytic Leukemia; Richter Syndrome

Summary: the purpose of this study is to evaluate the safety and effectiveness of targeted immunotherapy in combination with ublituximab and umbralisib, in patients with advanced cll or richter's transformation.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of b-cell chronic lymphocytic leukemia or richter's transformation * refractory to or relapsed after at least 1 prior treatment regimen * eastern cooperative oncology group (ecog) score of 0 to 2 exclusion criteria: * any major surgery, chemotherapy or immunotherapy within the last 14 days * known hepatitis b virus, hepatitis c virus or hiv infection * active autoimmune disorder (with the exception of autoimmune hemolytic anemia or itp)
the effect of pulsed electromagnetic field and progressive resistance exercise on knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to investigate the effect of pulsed electromagnetic field and progressive resistance exercise on knee osteoarthritis. it is experimental research study that look at the additive effect of pulsed electromagnetic field and progressive resistive exercise on pain level, patient-reported and performance-based physical function and quality of life for patients with knee osteoarthritis

background: osteoarthritis is the main cause of disability in elderly population.\[1,2\] it affects almost one third of individuals aged 65 and older and approximately 25% of osteoarthritis patients 60 years and older cannot perform activities of daily living.\[3\] the clinical symptoms that lead to disability in knee osteoarthritis are more frequent than all other joint complaint. a large body of evidence exists proving the beneficial effects of progressive resistance exercise (pre) in patients with knee osteoarthritis (oa).\[4,5,6\] pulse electromagnetic field(pemf) is a physical therapy modality that could be used for treating knee osteoarthritis (oa) and there emerging evidence suggesting its beneficial effect in reducing pain and improving function for knee osteoarthritis (oa)\[7\] the purpose of the study is to examine the effectiveness of using pulsed electromagnetic field (pemf) with progressive resistance exercise (pre) training in decreasing pain level ,improving physical function, and improving quality of life in patients with knee osteoarthritis (oa) a small randomized control trial conducted to recruit 32 patients with knee osteoarthritis (oa). participants with knee osteoarthritis (oa) as defined by american college of rheumatology recruited from prince basma educational hospital. eligible patients were randomly assigned to receive 24 sessions (3 sessions/week for 8 weeks) of either the combined (pre and pemf) treatment or pre only. participants will be evaluated at baseline, after the end of treatment protocol (8 weeks), and at 3 and 6 months follow up. mixed anova and repeated measure anova will be used to evaluate the differences between groups in pain, and physical function, and quality of life

Eligibility criteria:
inclusion criteria: * 40 year-old and above * diagnosed with unilateral or bilateral knee oa exclusion criteria: * patients with current or previous knee surgeries * inflammatory arthritis's (rheumatoid arthritis, gout, etc.) * alzheimer disease * parkinson disease * unable to walk unaided for 6 months to maximize the efficiency of our experiments we excluded patients if they: * have participated in progressive resistance training or received pulsed electromagnetic field treatment in the prior year * exercise regularly more than once a week.

Keywords: knee osteoarthritis pulsed electromagnetic field progressive resistance exercise
mangrove-sword bean-food bar on the weight and weight for age z score of under-five children

Conditions: Nutrition Poor

Summary: the goal of this clinical trial is to assess the effect of the food bar made from api-api mangrove (avicennia marina) and sword bean (canavalia ensiformis) blends on the weight and weight-for-age z score affected by a landslide disaster. the main questions aimed to answer are: * food bar supplementation can effect the weight and waz score of under-five children affected by landslides disaster? * balanced nutrition education can increase the mothers' knowledge on the balanced nutrition of under-five children? participants divided in to two group i.e.: * treatment/intervention group consumed 50 g mangrove sword bean food bar each day during 15 days. * control group consumed 50 g sword bean food bar each day during 15 days. * each group received balanced nutrition for mothers once at the first week of study.

eligibility criteria for under-five children: * aged between 12 and 59 months * male and female * living in cihanjuang village of sumedang district which affected by the landslide disaster * had malnutrition, normal, or over-nutrition status, and not suffering from infectious diseases.

Eligibility criteria:
inclusion criteria: * aged between 12 and 59 months * male and female living in cihanjuang village of sumedang district who affected by the landslide disaster * had malnutrition, normal, or over-nutrition status * not suffering from infectious diseases * willing to avoid consumption of any snacks other than the food bars and plain water exclusion criteria: * suffered from infectious or chronical diseases

Keywords: older people under-five children disaster weight mangrove-sword bean-food bar
implantation of a pudendal pna test lead for neuromodulation by the entrami technique in case of chronic perineal pain syndrome.

Conditions: Pudendal Impingement Syndrome

Summary: pudendal nerve release surgery in case of pudendal impingement syndrome is well described in literature.pudendal nerve modulation in case of chronic perineal pain is also a promising technique and some small studies exist. however, in the latter group, patient inclusion criteria are very heterogenous and so conclusions about efficacy are difficult to draw. in the surgery group, outcome results also vary between the different approaches but in general, there is room for improvement. after pudendal nerve release in chronic perineal pain syndrome, it can take up to 6 months before improvement for the patient is recorded. this is partially due to the complex chronic pain syndrome mechanism. nothing is known about the possible effect of early neuromodulation at the level of the pudendal nerve after his release. recently, two cadaveric studies were published which described a minimal invasive trans gluteal approach for pudendal nerve decompression and a pudendal electrode placement. in the present trial, the investigators would like to combine the endoscopic trans gluteal pudendal release with pudendal neuromodulation to improve the outcome for patients suffering from pudendal impingement syndrome. the aim is to improve the results of pain score and quality of life of patients undergoing surgery for pudendal release in case of chronic perineal pain syndrome.


Eligibility criteria:
inclusion criteria: * candidates for release surgery * patients meeting the five nantes criteria * chronic pain for more than 3 months exclusion criteria: * pregnancy * progressive neurological disease
changing of prostate specific antigen value in patients with covid-19

Conditions: Covid19; Prostate Specific Antigen

Summary: severe acute respiratory syndrome coronavirus 2 (sars-cov-2) caused a worldwide pandemic in over 100 years. the disease caused by this newly discovered virus was called covid-19. in this study, we aimed to evaluate changing of psa value in patients with covid-19.

patients with positive pcr test results were included in the study. the age of the patient and urea, leukocyte, hemoglobin, platelet, urea, and creatinine values of the patients were recorded. urinalysis and urine culture were taken from all patients. acute phase reactants such as sedimentation, c-reaktif protein (crp), ferritin, and fibrinogen were measured both at the time the patients applied and three weeks after the patient recovered. psa and free psa were also measured in the same way. patients whose symptoms improved and the pcr test result was negative were considered as recovered.

Eligibility criteria:
inclusion criteria: * male patients (\>45 and \<70 years of age) positive pcr test results were included in the study exclusion criteria: * the patients \ 70 years of age who described lower urinary tract symptoms who had urinary tract infection who a history of prostate biopsy and previous high level of psa who history of prostatitis were excluded.

Keywords: covid-19 prostate cancer prostate specific antigen
concomitant chemoradiotherapy with weekly paclitaxel and vinorelbine and granulocyte colony stimulating factor (gcsf) support in patients with advanced breast cancer

Conditions: Breast Cancer

Summary: the goal of this study is to determine the feasibility based on toxicity and response rate of giving paclitaxel weekly with concomitant every-other week radiotherapy to limit skin toxicity. this study will also seek to determine the maximally tolerated dose of navelbine added to this combination when followed by filgrastim and the dose-limiting toxicities of this regimen.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed adenocarcinoma of the male or female breast (male or female) with gross, uncontrolled, unresectable breast and/or chest wall disease including: 1. patients with locally advanced unresectable stage iiia or iiib; 2. patients with locally recurrent (including locoregional lymph nodes) disease for which curative surgery is not thought possible 3. patients with metastatic disease and uncontrolled locoregional disease are eligible. * prior chemotherapy allowed, except for nitrosoureas and mitomycin chemotherapy or high dose chemotherapy with marrow or stem cell rescue. * prior palliative radiation to sites of metastases allowed (i.e. bone, brain, lung) * 4 weeks since any prior treatments (excluding hormonal therapy). concurrent hormonal therapy is not allowed. * aged 18 years or older * calgb performance status of 0 - 2 * life expectance of at least 12 weeks * initial laboratory data: * anc count \> 1500/mm3 * platelet count \> 100,000/mm3 * creatine ≤ 2.0 mg/dl * bilirubin ≤ 1.5 mg/dl * alt (sgpt) ≤ 3 times the upper limit of normal * signed informed consent exclusion criteria: * prior breast or chest wall radiation is not allowed unless the proposed site radiation port does not overlap with prior ports * subjects must not be pregnant (females able to have children must have negative pregnancy test and agree to use adequate contraception) * patients with a documented hypersensitivity to e.coli derived proteins are excluded. * no other serious medical condition such as uncontrolled infection that in the opinion of the investigators places patient at undue risk for study treatment
klos study - korean medicine registry for low back pain patients, a prospective, observational, multicenter, pilot study

Conditions: Low Back Pain; Back Pain; Pain; Neurologic Manifestations; Nervous System Diseases

Summary: the purpose of this trial is to define the characteristics of the in/outpatients with low back pain in traditional korean medicine rehabilitation clinic. this information will create a registry that will help us to compare similarities and differences in patients and their symptoms. the more patients the investigators are able to enter into the registry, the more the investigators will be able to understand the low back pain and learn better ways of caring for patients.

klos, prospective, multi-center, patient registry pilot study will collaborate with 7 korean medicine hospitals and plan to recruit low back pain patients into the registry. 150 eligible patients with new episode of lbp who visit korean medicine hospital without any other treatment history will enroll to the registry. after enrollment, study collect the individual characteristics of patient's status such as pain intensity, lbp related daily disability, anthropometrics, hrqol at baseline, 30 and 90 days. we also access to the patient's clinical and administrative electronic records to analyze the pattern of patients' resource utilization. overall, the aims of klos are to: 1) explore the general characteristics of new episode of lbp patients and; 2) evaluate the efficacy and safety of various korean medicine treatments on low back pain based on nationwide registry outcome collecting process.

Eligibility criteria:
inclusion criteria: * inpatients with chief complaint of low back pain in korean medicine rehabilitation center * age greater than or equal to 19 * ability to have normal communication * ability to give informed consent exclusion criteria: * patients with low back pain which caused by other diseases(ex. lumbar herniated disc-surgery within past 3 months, vertebral fracture, inflammatory spondylitis, spinal infection, metastatic cancer etc.); * patient with musculoskeletal pain which is more severe than lower back pain; * patients with chronic disease may affect the results of clinical trial; * treated with medication for low back pain within past 4 months; * participated in other low back pain clinical trials within past 1 month; * patients who are inability to communicate, such as alzheimer's disease or mild cognitive impairment; * pregnant women; * patients who are judged to be inappropriate for the clinical study by the researchers

Keywords: low back pain korean rehabilitation clinic patient registry