Kornimate/medical-research-clean huggingface dataset:
long-term follow-up of hiv infected patients identified during early infection

Conditions: HIV Infections

Summary: this is a long-term follow-up study of people who are identified during acute or recent hiv infection and are being followed at clinical research sites associated with the acute hiv infection and early disease research program (aiedrp).

aiedrp was established to develop and evaluate data from studies of patients with acute or recent hiv infection. long-term effects of antiretroviral therapies raise questions regarding the value and necessity of therapeutic interventions during acute and early hiv infection. conventional randomized clinical trials are generally designed with finite endpoints; most patients who reach an endpoint or complete a protocol are no longer followed. as a result, long-term virologic, immunologic, and clinical outcome data are not available. this is particularly true for participants who fail therapy, require changes in treatment, or develop a treatment-limiting toxicity in a time-limited study. this database study will establish a cohort of hiv infected individuals who are participating in hiv studies at aiedrp sites and of hiv infected individuals who have chosen to defer therapy but agree to be followed by this study. the study will facilitate longitudinal and prospectively planned meta-analyses or cross-protocol analyses of aiedrp studies by developing data collection guidelines, defining common research goals, and creating data templates. the primary aim is to determine the long-term virologic, immunologic, and clinical outcomes and complications for patients who were diagnosed during acute or early hiv infection. participants in this study will be followed for at least 5 years. study visits will occur at weeks 2, 4, and 12, and then every 12 weeks thereafter, through week 96. after 2 years, study visits will occur every 24 weeks until the end of the study. participants who start antiretroviral therapy at or after week 2 will restart the study visit schedule. study visits will include a medical interview, adherence questionnaire, and blood tests. duplicate tests performed as part of another study will not be performed if the results of those tests are available.

Eligibility criteria:
inclusion criteria * documented acute or recent hiv infection * willing to allow study investigators access to and use of participant's medical information from other aiedrp clinical trials * parent or guardian willing to provide informed consent, if applicable * if enrolled at an aids clinical trial group (actg) site, must also be participating in one of the following clinical trials: ain501/actg a5216, ain503/actg a5217, or ain504/actg a5218 exclusion criteria * more than 7 days of antiretroviral therapy prior to study entry without adequate documentation of pretreatment viral load and cd4 count. individuals who have failed postexposure prophylaxis with antiretroviral treatment are not excluded from enrollment. * any factor that, in the opinion of the study official, may interfere with study participation

Keywords: acute infection treatment experienced treatment naive
pulse oximeter responses to multiple levels of stable hypoxia in neonates

Conditions: Hypoxia

Summary: validate pulse oximeter sensors in neonates by comparing sensor readings to blood samples during cardiac surgery.

researchers at the university of california, san francisco have developed methods that permit them to test multiple pulse oximeter sensors on neonates simultaneously during cardiac surgery. during this type of surgery, the arterial oxygen saturation changes over a wide range, providing an ideal arena for the assessment of neonatal pulse oximeter sensors at many levels of oxygen saturation. several arterial blood gas samples are typically obtained during these procedures. saturation of each arterial blood sample is determined by direct oximetry in a hemoximeter and this measurement is compared to the reading displayed on the pulse oximeter.

Eligibility criteria:
inclusion criteria: * neonatal patient scheduled to undergo cardiac surgery where routine blood draws would be taken * understand and provide signed parental/guardian consent exclusion criteria: * failure to obtain parental consent * patients shown to have an adverse reaction to medical tape/adhesive
investigation of the relationship between blood transfusion volume and development of renal failure in pediatric patients undergoing cardiovascular surgery

Conditions: Congenital Cardiac Defect; Acute Renal Injury; Blood Transfusion Complication

Summary: blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. there is not enough data on this subject for children in studies. investigators aim to examine the renal damage risk level of blood transfusion volume, which is one of the modifiable risk factors that can cause acute kidney injury in pediatric cases undergoing cardiac surgery. the main question it aims to answer is: what is the effect of blood transfusion volume on the risk of renal damage in pediatric cardiovascular surgery? the names of the patients who were operated on by the department of cardiovascular surgery will be accessed from the system records and their files will be reviewed. the patients' demographic information, anesthesia management and postoperative renal function tests will be scanned.


Eligibility criteria:
inclusion criteria: * pediatric patients undergoing cardiovascular surgery exclusion criteria: * being over 18 years old weighting over 30 kg preoperative acute kidney injury
efficacy and safety of mco-010 optogenetic therapy in adults with retinitis pigmentosa [restore]

Conditions: Retinitis Pigmentosa; Retinitis; Retinal Diseases; Eye Diseases; Eye Diseases, Hereditary; Retinal Dystrophies; Retinal Degeneration

Summary: the purpose of the study is to evaluate the safety and efficacy of a single intravitreal injection of virally-carried multi-characteristic opsin (mco-010).

this multicenter, randomized, double-masked, sham-controlled, dose-ranging study will evaluate 2 dose levels of mco-010 in up to 18 subjects with retinitis pigmentosa (9 per dose). an additional nine subjects will receive sham injection. subjects with a confirmed diagnosis of advanced retinitis pigmentosa (rp) based on clinical examination, dilated fundus examination, and genetic testing will be considered for participation in this study. all subjects will continue to be assessed for 100 weeks following treatment with mco-010.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. able to comprehend and give informed consent. 3. confirmed diagnosis of advanced retinitis pigmentosa (rp) based on clinical examination, dilated fundus examination, and genetic testing. 4. best-corrected (freiburg) visual acuity worse than 1.9 logmar (snellen equivalent 20/1600) in the study eye and no better than 1.6 logmar (snellen equivalent 20/800) in the fellow eye during screening. exclusion criteria: subjects are excluded from the study if any of the following criteria apply: 1. prior participation in gene therapy program 2. pre-existing conditions in the study eye such as glaucoma, diseases affecting the optic nerve causing significant visual field loss, active uveitis, corneal or lenticular opacities). 3. presence of any complicating systemic diseases such as malignancies whose treatment could affect central nervous system function. 4. active ocular inflammation or recurrent history of idiopathic or autoimmune associated uveitis. 5. having received retinal prothesis (such as argus-ii) or any gene or stem cell therapy (ocular or non-ocular).

Keywords: retinitis pigmentosa eye diseases hereditary eye diseases retinal degeneration inherited retinal diseases rod & cone dystrophies optogenetics gene therapy aav vectors intravitreal injections low vision multi-characteristic opsin no light perception visual acuity multi-luminance y mobility test (mlymt) multi-luminance shape discrimination test (mlsdt)
attentional focus strategies in exercise in patients with myofascial pain syndrome

Conditions: Myofascial Pain Syndrome

Summary: attentional focus is a concept of motor learning and the usage of this concept promotes exercise-induced muscular adaptations and affects motor performances. in practice,two main verbal instructions are directing the focus of attention; external focus (efa) and internal focus of attention (ifa). several studies show the results related with different health conditions. however, there is not enough studies to investigate the effectiveness of these attentional focus strategies in exercise regimes in patients with musculoskeletal problem. thus, the study will be the first to investigate the effectiveness of attentional focus strategies in patients with neck and upper back myofascial pain syndrome (mps) which is the most common syndrome of musculoskeletal problems.

when investigating the literature studies, there is insufficient evidence to determine which attentional focus strategies are more effective for improving function and decreasing pain in different health conditions. in most of the studies duration of symptoms of patients was not mentioned and there are no studies that directly compare efa and ifa and report the effects on pain or functional outcomes in musculoskeletal conditions.additionally, one study investigated the effectiveness of attentional focus strategies used in a training program but not in a musculoskeletal problem. thus, the study aims to investigate the effectiveness of attentional focus strategies in patients with neck and upper back mps in terms of pain, pressure pain threshold, quality of life, depression, disability, and posture parameters.

Eligibility criteria:
inclusion criteria: * symptomatic mps in the neck and upper back region (upper and middle trapezius, levator scapulae, rhomboids, infraspinatus, and supraspinatus muscles) confirmed by a physician, * pain lasting more than 3 months with a pain intensity is 3 or higher according to numeric pain rating scale (nprs⩾3). exclusion criteria: * fibromyalgia syndrome, cervical disc pathologies, malignancy, neurologic and/or inflammatory diseases, history of neck, shoulder, upper back surgery and trauma, other medical conditions that limit participation in exercise. * pregnancy * individuals being involved in physiotherapy or exercise sessions for at least 4 weeks

Keywords: pain pressure pain threshold quality of life depression posture myofascial pain syndrome attentional focus strategies
towards better prognostic and diagnostic strategies for haemostatic changes during major obstetric haemorrhage

Conditions: Postpartum Haemorrhage

Summary: major obstetric haemorrhage (moh) remains a cause of significant maternal morbidity and mortality worldwide. by identifying women with a higher a priori risk of major haemorrhage during their pregnancy or early during postpartum haemorrhage extra measures to prevent moh can be taken. in this study the investigators aim to identify haemostatic parameters that during the course of haemorrhage are responsible for the on-going towards major bleeding. by doing this, cut-off points can be defined for future interventions aiming to stop this bleeding process in an early stage. traditional coagulation parameters are currently not useful for clinical decision making, because of long turn around times. therefore the added value of available coagulation 'point of care' tests will be evaluated during obstetric haemorrhage.these point-of-care (poc) tests could lead to a goal-directed haemostatic therapy for obstetric haemorrhage. a cohort of 9.500 pregnant women will be followed during their pregnancy and delivery. from all women a bleeding score will be obtained during their pregnancy by means of a validated questionnaire. the predictive value of this bleeding score for the occurrence of major obstetric haemorrhage will be evaluated. if postpartum haemorrhage develops (blood loss) \> 1000 cc, blood samples will be drawn for conventional haemostatic parameters and rotem profiles. the pathway between minor bleeding and major bleeding will be elucidated. interchangeability and comparability of conventional haemostatic parameters and rotem profiles will also be evaluated. the overall goal of the investigators is becoming more able to predict major obstetric haemorrhage in an early stage of postpartum haemorrhage and define thresholds for goal-directed hemostatic therapies.

see 'brief summary'

Eligibility criteria:
inclusion criteria: - pregnancy, gestation age \> 24 weeks exclusion criteria: * age \< 18 * adults incapable of giving informed consent * gestational age \< 24 weeks
effects of dpp4 inhibitor on cisplatin induced acute kidney injury

Conditions: Cancer; Cisplatin Adverse Reaction

Summary: cisplatin is a potent chemotherapeutic agent, however, its nephrotoxicity manifested by acute kidney injury (aki) often limits applicability. dipeptidylpeptidase-4 (dpp4) inhibitors are well known to improve glucose intolerance by augmentation of endogenous glucagon like peptide (glp-1) and glucose-dependent insulinotropic peptide (gip). dpp4 inhibitor also has the potential anti-apoptotic and renoprotective effect in a mouse model of cisplatin-induced aki. this is a single-center, randomized, double-blind, parallel-group, placebo-controlled, prospective study to investigate the renoprotective effect of dpp4 inhibitor on cisplatin-induced aki. a total 182 patients, who are scheduled to treat with cisplatin, will be recruited and randomly assigned to either gemigliptin or placebo groups. subjects will take study drugs for 8 days starting from one day before cisplatin treatment. serum creatinine (cr) and estimated glomerular filtration rate (egfr) will be measured at 7 days after cisplatin treatment.

this study will investigate possible renoprotective effects of dpp4 inhibitor on cisplatin induced acute kidney injury.

Eligibility criteria:
inclusion criteria: * age \> 18 years * cancer patients treated with intravenous cisplatin * written consent exclusion criteria: * diabetes mellitus * chronic kidney disease stage iv-v (egfr \< 30ml/min/1.73m2) * history of transplantation * history of acute kidney injury before randomization * use of other nephrotoxic agents such as non steroidal anti-inflammatory drugs, aminoglycosides, colistin, vancomycin * receiving contrast media during last 72 hours * liver disease (bilirubin \> 2 mg/dl, transaminase levels \>2.5 times the upper limit normal) * active infection * patients with high risks of dehydration owing to poor oral intake * high blood pressure (\> 180/110 mmhg despite antihypertensive medications) * hypersensitivity to gemigliptin or its excipients * low compliance to gemigliptin treatment

Keywords: cisplatin nephrotoxicity gemigliptin dpp4 inhibitor
rct of internet-delivered cbt treatments for pathological gambling: comparing the effects of added involvement from csos

Conditions: Gambling

Summary: background: problem gambling is a public health concern with prevalence rates at 2 %. problem gambling also severely affects concerned significant others (csos). several studies have investigated the effects of individual treatments based on cognitive behavior therapy (cbt), but there is a shortage in studies on the effect of involving csos in treatment. this study aims to compare an intervention based on behavioral couples therapy (bct) involving a cso with an individual cbt treatment to determine their relative efficacy. bct has shown promising results in working with substance abuse, but this is the first time it is used as an intervention for problem gambling. both interventions will be internet-delivered and participants will receive e-mail and telephone support. method/design: a sample of at least 100 couples will be randomized to either the bct condition or the cbt condition. the participants will work through 10 modules over 12 weeks in a secure online environment, and receive support via email and over telephone. repeated measures will be conducted weekly and at 3, 6 and 12 months follow-up. the primary outcome measure is gambling behavior, defined as time spent and money lost on gambling, as measured by timeline follow-back. secondary outcomes include gambling related harm, alcohol consumption, relationship satisfaction and mental health for the gambler as well as for the cso. hypotheses: the investigators hypothesize that a) bct will yield greater reductions on gambling measures than cbt, b) bct will yield a lower drop-out rate compared to cbt, c) bct will be superior to cbt on increasing relationship satisfaction, d) relationship functioning will mediate change in gambling behavior in the bct group and e) reduction in gambling behavior will mediate change in relationship functioning in the cbt group.


Eligibility criteria:
inclusion criteria: * the cso is a parent, child, sibling, friend or partner of the gambler. * participants are at least 18 years old. * the gambler is a problem gambler according to problem gambling severity index. * participants must have had a relationship with the gambler for at least 3 months. * participants must be able to read and answer questions in swedish, and is willing to be in contact with a counselor each week. * participants must have access to internet. exclusion criteria: * participants are currently in any other treatment related to problem gambling. * the cso is a problem gambler according to problem gambling severity index. * participants displaying symptoms of severe psychiatric disorders, such as psychotic- or bipolar disorders, judged to require further treatment.

Keywords: concerned significant other problem gambling internet-delivered cognitive-behavioral therapy behavioral couples therapy
musculoskeletal disorders among egyptian anesthesiologists

Conditions: Musculoskeletal Disorders

Summary: this cross-sectional online survey questionnaire based study for prevalence and risk factors of work related musculoskeletal disorders among egyptian anesthesiologists.

this cross-sectional online survey questionnaire based study will be approved by medical ethical committee of sohag faculty of medicine. survey participants will be reassured that all data collected are for research purposes. responses will be voluntary anonymous and have no identifying data. egyptian anaesthesiologists will be invited through social media to participate in the survey.

Eligibility criteria:
inclusion criteria: * egyptian anesthesiologists on clinical practice exclusion criteria: -
misoprostol for treatment of postpartum hemorrhage at community-level births in egypt

Conditions: Postpartum Hemorrhage

Summary: this randomized controlled community-based trial will assess the effectiveness of administration of 800 mcg sublingual misoprostol with standard of care vs. placebo with standard of care for postpartum hemorrhage treatment at the community level, primarily home births attended by primary health care unit (phu) staff in etay el barood and kafr el dawar districts (el beheira governorate), egypt. standard of care per national guidelines in this setting is referral to a higher level health facility.

hospital-based clinical trials have demonstrated misoprostol to be a safe and effective treatment option for postpartum hemorrhage (pph). additional research is needed to demonstrate how these findings translate into program effectiveness at lower levels of the health care system, including community home births, where access to skilled providers and treatment options are limited and misoprostol could potentially have the greatest impact on maternal health outcomes. this randomized controlled community treatment trial will assess the effectiveness of misoprostol with standard of care (i.e., referral to higher level care) vs. placebo with standard of care for pph treatment at the community level, primarily home births attended by primary health care unit staff in etay el barood and kafr el dawar districts (el beheira governorate), egypt. this research will help guide decisions on how to introduce misoprostol into pph care programs in different contexts such as primary care settings, including community-based home births.

Eligibility criteria:
inclusion criteria: * women delivering with provider from participating primary health unit (phu) * willing and able to give informed consent * vaginal delivery exclusion criteria: * women too advanced into active labor to provide informed consent * known allergy to misoprostol and/or other prostaglandin * women presenting with pregnancy complications, such as hypertension, suspected multiple pregnancy, previous caesarean section, suspected still birth, antepartum hemorrhage, previous complication in the third trimester (should be referred to higher level care for delivery)

Keywords: postpartum hemorrhage treatment misoprostol home births
epidemiology of sepsis in china

Conditions: Sepsis

Summary: sepsis is a common cause for morbidity and mortality in critically ill patients. in usa, the incidence of sepsis is about 3/1000 population. however, the incidence of sepsis varies among different clinic trails. in addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. in china, the mdro is much higher than western country. there is no study about the epidemiology of sepsis in china. therefore, it is necessary to conduct a study about it in china.

sepsis,especially severe sepsis is a major cause of admission to the intensive care unit (icu) and death. in usa, the incidence of sepsis is about 3/1000 population. however, the incidence of sepsis varies among different clinic trails. between 6 and 54% of patients admitted to icus have severe sepsis and the mortality rate for these patients varies from 20 to 60%. there is no exactly results of incidence of sepsis in china. in addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. in epic ii study, the organisms of sepsis include gram-positive microorganisms (69.8%),gram-negative microorganisms(62.2%) and fungi (17%). in china, the mdro is much higher than western country. in contrast to epic ii study, one study in china showed that the organisms of sepsis include gram-positive microorganisms (14.5%),gram-negative microorganisms(62.5%) and fungi (2.2%). therefore, it is necessary to conduct a study about epidemiology of sepsis in china.

Eligibility criteria:
inclusion criteria: sepsis patients who admitted into icu during research period (include patients with sepsis at icu admission and patients who has new sepsis during icu period) exclusion criteria: the patients with second sepsis in icu