Kornimate/medical-research-clean huggingface dataset:
evaluation of an integrative medicine outpatient clinical setting for post-covid-19 patients

Conditions: COVID-19; Fatigue

Summary: the study aims to identify whether a multimodal integrative naturopathy outpatient clinical concept can improve the symptoms of patients suffering from post-covid-syndrome. main outcome is fatigue. the outpatient clinical programme consists of 11 weeks wherein patients visit the clinic one day per week. the pillars of classical naturopathy are combined with extended naturopathy and complementary procedures. previous naturopathical studies on patients with chronic fatigue syndrome could find numerous indications that different types of naturopathy can help patients with fatigue.


Eligibility criteria:
inclusion criteria: * 18 to 75 years of age * diagnosed with post covid syndrome * fatigue with or without myalgia * signed declaration of consent exclusion criteria: * contraindications for whole body infrared hyperthermia (severe cardiovascular diseases, tumour diseases, acute infections, pregnant and breastfeeding women) * acute and or feverish microbially infections * pleuritic chest pain * relevant shortness of breath * zn critical illness or intensive medical care because of covid 19 * patients with severe somatic, cardiovascular pneumological, rheumatic, endocrine or neurological comorbidities. especially neurological disorders accompanied by cognitive impairment, severe liver or kidney disorders. * patients permanently treated with opioids, cannabis, immunosuppressive agents (e.g. corticoids, immunsuppressives) or alpha/beta-a(nta)gonists * patients with pain as a consequence of a severe psychiatric disease (bipolar disorder, psychosis, personality disorder, severe depression, substance abuse) as well as severe systematic disorders or neurological disorders * participation in other clinical studies

Keywords: covid-19 fatigue outpatient clinic integrative naturopathy integrative medicine
combined model of online remote interventions for cancer-related cognitive impairment

Conditions: Cognitive Decline; Cancer

Summary: cancer survival rates have increased dramatically in recent years. however, many survivors report cognitive decline following treatment, which significantly impairs their quality of life. online cognitive training programs have shown promise in improving cognitive functions in cancer survivors, but most studies report limited impact of training on everyday function. a complementary treatment approach is functional treatment delivered by occupational therapists, which directly targets daily function. combining the two approaches has the potential to overcome the limitations of both approaches, enabling improved cognitive functions and transfer to daily function. remotely-administrated interventions further make treatment accessible and cost-effective. the current study is aimed at testing the efficacy of a novel, combined, remotely-delivered treatment approach: cognitive retraining and functional treatment(craft), using a randomized controlled trial (rct) design. 90 cancer survivors will be randomly assigned to receive 15 weeks of either the combined treatment, computerized training only, or treatment-as-usual. outcomes will be assessed at completion, and following 3 months of no contact, to test immediate and enduring effects of treatment. baseline predictors for treatment response will be further assessed. positive results in the proposed study could potentially change the therapeutic landscape for rehabilitation of cancer-related cognitive decline, which currently impair the lives of millions worldwide.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18; 2. subjective concern about declines in cognitive functioning related to a diagnosis of cancer and/or cancer related treatment. this will be obtained by asking participants the question "do you have concerns about your memory or other thinking abilities following cancer treatment?". participants are required to answer yes to this question. 3. interested in treatment and state they have 2 weekly hours available for the intervention. 4. completion of active treatment for non-central nervous system (cns) cancer (e.g., chemotherapy,radiation therapy and surgery) 6 months or more in the past. 5. cognitive decline with no dementia: 21\<mini-mental state examination \<27 (folstein, folstein, \& mchugh, 1975) and/or 19\< montreal cognitive assessment \<26 (nasreddine et al., 2005); 6. daily access to a computer and internet facilities; 7. able to sign an informed consent; 8. stable psychiatric condition (according to participants self- report and medical file). exclusion criteria: 1. no prior experience using computers; 2. pregnancy; 3. history of a central nervous system tumor.

Keywords: cancer related cognitive impairment telerehabilitation computerized cognitive training adult cancer survivors functional treatment
hemodynamic changes in off-pump coronary artery bypass grafting

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to study the positioning and stabilization of different cardiac walls performed during off-pump coronary artery bypass grafting (cabg) may have dissimilar impact on hemodynamics. the objective is to evaluate hemodynamics during distal coronary anastomoses in different cardiac walls.

* twenty patients undergoing off-pump cabg monitored with pulmonary artery catheter and esophageal doppler will be enrolled. * patients with a left ventricular ejection fraction \ 80 yr, creatinine \>1.4 mg/dl, reoperation, valvular heart disease or chronic obstructive pulmonary disease were excluded * data will be collected after volemic and hemodynamic adjustments, after heart positioning and establishment of a suction stabilizer and before its removal in anterior, lateral or posterior wall artery anastomosis. * data was compared by means of two-way repeated measures anova.

Eligibility criteria:
inclusion criteria: * normal left ventricular function * minimal to moderate surgical risk according to criteria proposed by higgins et al. (jama. 1992 may 6;267(17):2344-8) exclusion criteria: * patients with a left ventricular ejection fraction \<50%, * age \>80 yr * creatinine \>1.4 mg/dl * reoperation * valvular heart disease * chronic obstructive pulmonary disease * high surgical risk according to criteria proposed by higgins et al. (jama. 1992 may 6;267(17):2344-8)

Keywords: opcab pulmonary artery catheter esophageal doppler hemodynamics
computer based training in cbt in primary care

Conditions: Substance Abuse

Summary: to conduct an 8-week randomized trial evaluating the feasibility and efficacy of adding cbt4cbt to treatment as usual in a community based primary care program in a population of 60 individuals who meet current dsm criteria for substance use disorder other than nicotine.

the investigators will conduct an initial evaluation of the computer program as an enhancement of treatment as usual in a community-based primary care clinic. sixty individuals with a current dsm-iv alcohol or substance use disorder will be randomly assigned to either (1) treatment as usual, or (2) treatment as usual plus exposure to the 'cbt for cbt' program over a period of 8 weeks. primary outcomes will be retention in treatment and reduction in drug use over 8 weeks. secondary outcomes include treatment utilization

Eligibility criteria:
inclusion criteria: * are 18 years of age or older. * are applying for outpatient substance abuse treatment * meet current dsm-iv criteria for cocaine, marijuana, opioid, alcohol or other stimulant use disorder * are sufficiently stable for 8 weeks of outpatient treatment * can commit to 8 weeks of treatment and are willing to be randomized to treatment * are willing to provide locator information. exclusion criteria: * have an untreated bipolar or schizophrenic disorder * have a current legal case pending such that incarceration during the 8 week protocol is likely * are in need of detoxification from alcohol, opioids or benzodiazepines
early add-on vildagliptin in patients with type 2 diabetes inadequately controlled by metformin

Conditions: Type-2 Diabetes Mellitus

Summary: the purpose of this study was to observe change of hba1c over time from baseline to month 12. the ultimate goal of this study was to provide a local reference value to the physicians \& patients in the future when they consider initiating vildagliptin and taking balance between efficacy, compliance, risk factors, convenience and medication cost.


Eligibility criteria:
inclusion criteria: 1. male or female in age ≥18 at visit 1 2. type 2 diabetes mellitus (t2dm) patients on their maximum tolerated dose of metformin for more than 3 months 3. hba1c (glycosylated hemoglobin) at visit 1 greater than 7.0% 4. with nearest documented record of hba1c before visit 1 greater than 7.0% after patient reached his/her maximum tolerated dose of metformin key exclusion criteria: 1. patients with hepatic impairment, including patients with a pre-treatment alanine aminotransferase (alt) or aspartate aminotransferase (ast) \> 2.5 x the upper limit of normal at visit 1 2. patients with moderate or severe renal impairment or end-stage-renal-disease (esrd) on haemodialysis at the time of enrolment 3. patients with hereditary problems of galactose intolerance, the lapp lactose deficiency or glucose-galactose malabsorption 4. pregnant women or breastfeeding women at the time of enrolment 5. use of insulin or other oral anti-diabetic drug (oad) apart from metformin in the past for t2dm treatment

Keywords: type-2 diabetes mellitus, inadequately controlled metformin
ciropractic care and pregnant women

Conditions: Pain, Back; Pregnancy Related; Sleep; Quality of Life

Summary: objective: the aim of this study is to investigate the effectiveness of chiropractic care on pain, quality of life and sleep in pregnant women compared to a control group. the study is designed as non-randomized controlled trial. forty-two pregnant women at least on the 14th week of gestation will be included. control group will include women receiving regular care, but no chiropractic care. care will extend for 4 weeks. outcomes measures include sleep quality, pain and quality of life questionnaires.


Eligibility criteria:
inclusion criteria: * pregnant women over the age of 18 * of at least 14 weeks gestation, * with a good understanding of english, spanish or french. exclusion criteria: * women over the age of 45, * pregnancies of more than 35 weeks gestation * high-risk pregnancies (tobacco, alcohol or substance use, diagnosed medical conditions or high blood pressure).

Keywords: chiropractic
pmcf study of preloaded trifocal iol

Conditions: Cataract

Summary: this is a study to evaluate the safety, effectiveness and patient satisfaction of the trifocal intraocular lens after implanted to replace the natural lens following cataract removal.

this study is a single-arm unmasked clinical evaluation study of safety, effectiveness and patient satisfactions of the trifocal intraocular lens after successful bilateral cataract surgery. subjects will be assessed pre-operative, operative date and at 1-2 days, 1-2 weeks, 1-2 months, 3-4 months and 6 months post-operative. clinical evaluations will include probability of adverse events, patient satisfaction questionnaire, as well as measurements of monocular and bilateral far, intermediate and near visual acuity as a result of trifocal lens performance, etc.

Eligibility criteria:
inclusion criteria: * bilateral cataracts: adults, 20 years of age or older at the time of informed consent, of either gender, diagnosed with bilateral cataracts * desire for high post-operative spectacle independence * willingness to cooperate with and complete all post-operative visits * calculated lens power within +5.0 d and +34.0 d * planned cataract removal by phacoemulsification * clear intraocular media other that cataracts in both eyes * potential post-operative visual acuity of 20/25 or better * ability to comprehend and sign an informed consent * signed informed consent exclusion criteria: * more than 1.0 d of pre-operative corneal astigmatism * expected post-operative astigmatism of more than 0.75 d * mature/dense cataract which makes the pre-operative fundus examination difficult * previous ocular surgery or trauma * clinically significant irregular astigmatism * choroidal hemorrhage * microphthalmos * severe corneal dystrophy * medically controlled or uncontrolled glaucoma * clinically significant macular/rpe changes * concomitant severe eye disease * severe optic nerve atrophy * diabetic retinopathy, proliferative or macular edema * amblyopia * extremely shallow anterior chamber * chronic sever uveitis * pregnant or lactating * previous retinal detachment * previous corneal transplant * concurrent participation in another drug or device investigation * may be expected to require other ocular surgery during the study

Keywords: cataract trifocal iol intraocular lens preloaded aphakic spectacle independence asqelio aspicio ast products icares
optic nerve sheath diameter in patients with intracranial pathology

Conditions: Elevated Intracranial Pressure (ICP)

Summary: elevated intracranial pressure (icp) is a common and potentially life threatening condition arising from a variety of pathological conditions. the ability to monitor icp is a crucial aspect in the management of these patients. currently, the diagnosis of whether icp is elevated or not is determined either with clinical signs (headache, nausea and vomiting or visual disturbances) or from the changes in the preoperative neuroimaging modalities such as computerized tomography (ct scan) and/or magnetic resonance imaging (mri). recently, transorbital ultrasonography has gained popularity as a noninvasive bedside exam that has been shown to be useful in the diagnosis of raised icp by evaluating the change in the optic nerve sheath diameter (onsd). the aim of our study is to use transorbital ultrasound to evaluate onsd changes in patients with intracranial pathology and to compare the changes in the onsd before and after surgical intervention as well as between patients with and without clinical or radiological signs of increased icp.

elevated intracranial pressure (icp) is a common and potentially life threatening condition arising from a variety of pathological conditions. the ability to monitor icp is a crucial aspect in the management of these patients. currently, the diagnosis of whether icp is elevated or not is determined either with clinical signs (headache, nausea and vomiting or visual disturbances) or from the changes in the preoperative neuroimaging modalities such as computerized tomography (ct scan) and/or magnetic resonance imaging (mri). recently, transorbital ultrasonography has gained popularity as a noninvasive bedside exam that has been shown to be useful in the diagnosis of raised icp by evaluating the change in the optic nerve sheath diameter (onsd). the aim of our study is to use transorbital ultrasound to evaluate onsd changes in patients with intracranial pathology and to compare the changes in the onsd before and after surgical intervention as well as between patients with and without clinical or radiological signs of increased icp.

Eligibility criteria:
inclusion criteria: * intracranial pathology patients scheduled for elective or emergency surgery. * american anesthesiologist society physical status classification system (asa) 1-4 exclusion criteria: * history of glaucoma, * previous retinal surgery, * optic neuritis, * lack of informed consent, * pregnancy
special drug use-results survey for long-term use（avacopan）

Conditions: Microscopic Polyangiitis (MPA); Granulomatosis With Polyangiitis (GPA)

Summary: the purpose of this survey is evaluating the safety and efficacy of long-term administration of avacopan for japanese patients with microscopic polyangiitis or granulomatosis with polyangiitis under actual conditions of use.

the purpose of this survey is evaluating the safety and efficacy of long-term administration of avacopan for japanese patients with microscopic polyangiitis or granulomatosis with polyangiitis under actual conditions of use.

Eligibility criteria:
inclusion criteria: * patients with granulomatosis with polyangiitis or microscopic polyangiitis who are treatment with avacopan
intra-individual variability and circadian rhythm of vegf levels and interaction with biomarkers

Conditions: Diabetic Macular Edema

Summary: the study evaluates the intra-individual variability of vegf levels over a period of 6 months as well as the circadian variation of vegf levels, both under standardized conditions in patients with type 2 diabetes without dme and matched subjects with normal glucose tolerance (ngt). secondary objectives of the study are to evaluate the relationship of individual vegf-levels to biomarkers of inflammation, hba1c and major cardiovascular risk factors.


Eligibility criteria:
inclusion criteria: * written informed consent * age equal to or between 50 and 80 years * subjects with normal glucose tolerance confirmed by glucose tolerance test (control group) or patients with type 2 diabetes: diabetes duration 5-25 years; hba1c equal to or between 6.5 and 9% (diabetes group) * ability to understand and follow study-related instructions exclusion criteria: * dme * hscrp \> 10 mg/dl * acute infections * acute or chronic inflammatory diseases * immune diseases * treatment with immune suppressive drugs * treatment with glucocorticoids * myocardial infarction and stroke within 1 year before inclusion * hemorrhage within the previous 5 years * surgeries within the previous 3 months * oncological diseases * women who are pregnant or breast-feeding
european disease registry on retinopathy of prematurity (rop)

Conditions: Retinopathy of Prematurity

Summary: the eu-rop registry is a european wide multicenter non-interventional observational registry study intended to run open-ended in as many countries as possible including infants treated for retinopathy of prematurity irrespective of the used treatment modality. the registry is strictly observational; only clinical routine data is collected, no study-specific examinations or interventions are to be performed. the aim of the eu-rop registry is to collect information on as many patients as possible treated for rop in europe. both the number of study centers as well as the number of patients to be included into the registry are not limited. the primary objective is to describe the typical clinical features of infants with severe rop, variations in phenotype, and the clinical progression of the disease over time (natural history) in different european countries as well as to study treatment patterns, follow-up patterns, as well as long-term outcomes.


Eligibility criteria:
inclusion criteria: * rop requiring treatment according to the respective national rop screening and treatment guidelines exclusion criteria: * denial or absence of consent for documentation and electronic storage of personal data by parents or legal guardians

Keywords: rop anti-vegf laser coagulation epidemiology non-interventional study
retrospective chart review study to assess characteristics, treatment outcomes and resource use of adults hospitalized for cap and cssti treated with zinforo in multiple countries

Conditions: Community Acquired Pneumonia; Complicated Skin and Soft Tissue Infection

Summary: multinational retrospective chart review study to assess the characteristics, treatment outcomes and resource use among adult patients hospitalized for community-acquired pneumonia (cap) or complicated skin and soft tissue infections (cssti) treated with zinforo® (ceftaroline fosamil) in a usual care setting

the overall study aim is to provide real world evidence (rwe) on the characteristics, clinical management, treatment outcomes and healthcare resource use of adult patients aged 18 years and older admitted to the hospital for cap or cssti who received zinforo® in a usual care setting in europe and latin america on or before 31-may-2019.

Eligibility criteria:
inclusion criteria: 1. age 18 years or older at admission date to the hospital; 2. received four (4) or more consecutive iv doses of zinforo® in usual care on or before 31-may-2019; and 3. admitting diagnosis to the hospital was either cap or cssti. exclusion criteria: 1. patients who were participating in an interventional clinical trial during the same hospital admission in which zinforo® was administered; 2. patients whose hospital medical records are missing documentation of the diagnostic criteria for either cssti or cap; 3. patients whose hospital medical records are missing details of dosing with zinforo®; 4. patients whose hospital medical records are missing information on the success/failure of zinforo® treatment and the reason why treatment was discontinued; and 5. patients whose hospital medical records are missing discharge date and status information.

Keywords: bacteria zinforo® (ceftaroline fosamil) cap cssti hospitalized infectious disease antibiotic cephalosporin
trial to evaluate the effects of the german echeckup to go in students

Conditions: Alcohol Consumption

Summary: the purpose of this study is to evaluate the effects of the german echeckup to go (echug-d) in students. compared to the control group subjects who conducted echug-d should have less alcohol consumption and less alcohol associated problems after three and six months.

the effectivity of the echug-d will be checked through a prospective randomized-controlled web-study. all students at the participating universities will be informed about the psst-study. they have to agree to the informed consent to take part in the study. a missing agreement leads to exclusion. all subjects get an individual random login-code for study participation. after random assignment (intervention (echug-d) vs. control group) all subjects have to answer the same web-questionnaires about their alcohol consumption (see outcome variables). subjects of the intervention group are then requested to conduct echug-d and to fill in their login-code at the end of the program. the 3-month and 6-month follow-ups contain similar questions about alcohol consumption and alcohol related consequences. on 6-month follow-up additional questions ask about the acceptance of echug-d (intervention group) and the acceptance of the study in general (control condition). earlier studies showed the effectiveness of echug in us college samples. the primary endpoint of the study ist the amount of alcohol consumed. we hypothesize that the echug group will show significantly lower levels of alcohol intake than the control group

Eligibility criteria:
inclusion criteria: * any student exclusion criteria: * ongoing recuperation

Keywords: alcohol consumption binge drinking web-based personalized feedback program students