Kornimate/medical-research-clean huggingface dataset:
erythropoietin therapy for children with cerebral palsy

Conditions: Cerebral Palsy

Summary: this randomized placebo-controlled trial aims to investigate the efficacy and safety of erythropoetin for children with cerebral palsy.

cerebral palsy is a disorder of movement and posture resulted from a nonprogressive lesion or injury of the immature brain. it is a leading cause of childhood onset disability. many experimental animal studies have revealed that erythropoietin is useful to repair neurological injury in brain. the main mechanism of erythropoietin is supposed as follows; 1. neuroprotection effect 2. angiogenesis 3. anti-inflammation. on the basis of many experimental studies, erythropoietin is suggested as a therapeutic method for cerebral palsy.

Eligibility criteria:
inclusion criteria: * cerebral palsy * abnormal muscle tone * abnormal brain mri * willing to comply with all study procedure exclusion criteria: * known genetic disorder * other etiologies contributing developmental delay * coagulopathy * initial high erythropoietin level in serum * previous erythropoietin treatment before 3 months * presence of drug hypersensitivity related to the study remedy * intractable seizure disorder * poor cooperation of guardian including inactive attitude for rehabilitation

Keywords: cerebral palsy erythropoietin rehabilitation
an arrhythmia risk predictor trial

Conditions: Cardiomyopathy; Heart Failure

Summary: this prospective single-center study is an observational risk stratification trial in about 250 patients with standard indications for icd treatment. implantable cardioverter defibrillators (icd) have been shown to improve survival and current guidelines recommend their use for primary and secondary prevention of sudden cardiac death (scd). however, a large number of patients never receive an appropriate therapy from their device. in contrast, electrical sorm and multiple icd shocks occur in other patients. thus, identification of predictors for survival or icd shocks is necessary for improved patient selection and optimized therapeutic strategies. risk stratification with electrocardiogram (ecg) and signal averaged ecg (saecg), t-wave alternans (twa) and holter ecg including premature ventricular contractions (pvc), non-sustained vt (nsvt), heart rate variability (hrv), heart rate turbulence (hrt) and deceleration capacity, as well as clinical variables is possible, but not implemented in clinical routine in patients with ischemic or dilated cardiomyopathy and newly implanted icd for primary or secondary prevention of scd following current guidelines. patients will be prospectively followed and the predictive value of the risk markers mentioned above to predict all-cause mortality or appropriate icd shocks will be investigated.


Eligibility criteria:
inclusion criteria: * ischemic or dilated cardiomyopathy * sinusrhythm * icd indication strictly following current guidelines (primary and secondary prevention of scd) * age 18 years or older exclusion criteria: * no consent * atrial fibrillation

Keywords: sudden cardiac death risk stratification t-wave alternans holter electrocardiography heart rate turbulence
study evaluating the safety of ketonaph ophthalmic solution in healthy volunteers

Conditions: Allergic Conjunctivitis

Summary: this study is being conducted to evaluate the safety of ketonaph ophthalmic solution in healthy adult subjects and in pediatric subjects with a history or family history of ocular allergy.


Eligibility criteria:
inclusion criteria: * subjects less than 18 years of age, have either a history or family history of ocular allergy. * ocular health within normal limits, including a calculated best-corrected visual acuity of 0.3 logmar or better, in each eye. for subjects under 10 years old who are developmentally unable to use the etdrs chart, visual acuity will be made using the lea symbols. for these subjects, 20-foot snellen equivalent units of 20/63 or better in both eyes will be required. exclusion criteria: * contraindications or sensitivities to the use of any of the investigational product(s) or their components. * subjects less than 18 years of age that have had symptoms and/or signs of allergic conjunctivitis/rhinitis and/or treatment with topical or systemic anti-allergy therapy, or have had a history of ragweed hypersensitivity during the 21-day period prior to visit 1. * surgical intervention within three months prior to visit 1 or during the refractive surgery within the past 6 months. * a known history of retinal detachment, diabetic retinopathy, or active retinal disease; * an active ocular infection (bacterial, viral or fungal * use of any topical ophthalmic agents other than investigational products during study participation or within 5 days of beginning study treatment. * current or anticipated use of contact lenses during study participation or within 5 days of beginning study treatment. * current, prior (within 14 days of beginning study treatment) or anticipated use of systemic corticosteroids, and/or any other systemic medications which the investigator feels may confound study data or interfere with the subject's study participation. prior (within 21 days of beginning study treatment), current or anticipated use of any topical (including nasal) or systemic anti-allergy medications. * intraocular pressure (iop) that is less than 5 mmhg or greater than 22 mmhg or have a normal iop with a diagnosis of glaucoma.
causes and underlying factors of faltering growth among infants

Conditions: Infants Aged One Month to 2 Years , Infants With Any Type of Feeding (Breast or Artificial or Weaned Attend Assiut University Children Hospital )

Summary: to research in the different causes of failure to thrive in children including organic and non organic causes

altered growth velocity in infants has been traditionally described by the term (failure to thrive ) . more recently the preferred terms are faltering growth ,slow weight gain or undernourishment as failure to thrive has been associated with negative connotations of parents failing in their job as careproviders. the expression 'to falter' means to hesitate. faltering growth is an observation,without value judgement, of slower than expected rate of growth along an infant's previously defined growth curve. faltering growth is a common pediatric problem with many untoward effects . more studies showed that children who failed to thrive in infancy are lighter and shorter at school age with adverse intellectual outcomes (corbett and drewett,2004)(natale etal., 2014). weight faltering in the first months of life is particularly associated with these adverse effects. infants with faltering growth also have a higher prevalence of feeding problems (young etal., 2013).growth failure is more common during infancy than during any other stage of life because programmed growth rates and nutritional needs are high (

Eligibility criteria:
inclusion criteria: :infants attending assiut university children hospital who are stunting(decrease height for age ), wasting(decrease weight for lenght ), and underweight (decreases weight for age ) . when all of theses less than -1 z scores (normal z-score from -1 to +1 ) . also mid arm circumference below than 115 mm exclusion criteria: children complaining of any of the follolowing: * malignancy
does capnography prevent hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound?

Conditions: Hypoxemia

Summary: subjects undergoing elective ercp and eus will receive standard monitoring and sedation. in addition, capnography which measures carbon dioxide levels and can graphically assess respiratory activity will be used. subjects will be randomized to either a capnography blinded or titration arm. in the capnography titration arm, the endoscopy team would be made aware of capnographic abnormalities as they arise throughout the procedure. in the capnography blinded arm, this information will not be available to the endoscopy team and represents standard of care. it is our hypothesis that using capnography can prevent low oxygen levels known as hypoxemia, during these procedures.

subjects undergoing elective ercp and eus will receive standard monitoring and sedation. in addition, capnography which measures carbon dioxide levels and can graphically assess respiratory activity will be used. subjects will be randomized to either a capnography blinded or titration arm. in the capnography titration arm, the endoscopy team would be made aware of capnographic abnormalities as they arise throughout the procedure. in the capnography blinded arm, this information will not be available to the endoscopy team and represents standard of care. it is our hypothesis that using capnography can prevent low oxygen levels known as hypoxemia, during these procedures. the primary outcome of our study is the proportion of patients with hypoxemia in the two arms. review of the literature indicates that the incidence of hypoxemia without supplemental oxygen varies from 30-70%. our sample size calculation is based on a reduction of the hypoxemia incidence from 40% to 20%. secondary outcomes will be the proportions of patients with oxygen requirements, major hypoxemia and apnea (lack of respiratory activity via capnography for at least 15 seconds) in the two arms. we will perform a univariable and multivariable analysis to determine the risk factors for apnea.

Eligibility criteria:
inclusion criteria: * adults age 18 or greater * subjects undergoing elective ercp and eus * asa class 1-3 * inpatient and outpatient * able to give informed consent exclusion criteria: * asa class 4 and 5 * emergent procedures * procedures requiring mac sedation * subjects unable to give informed consent * subjects on oxygen before procedure * subjects on cpap/bipap * allergies to fentanyl/demerol/midazolam

Keywords: hypoxemia capnography apnea sedation ercp eus
evaluation of the risk of vte among patients hospitalized in non-surgical departments

Conditions: Thromboembolism

Summary: patients hospitalized in internal wards are at risk for vte. the current guidelines recommend the use of thromboprophylaxis for 7-10 days among patients who are at increased risk for vte. yet several retrospective studies have shown that the compliance with this guideline is low. physicians are often reluctant to administer lmwh to their fragile patients mainly because they are not convince that the risk associated with such therapy is greater than the risk for vte. in the current study, data concerning the use of thromboprophylaxis among patients admitted to the medical wards will be collected. the occurrence of bleeding or thrombotic event will be evaluated prospectively.

data concerning the use of lmwh among patients admitted to the medical wards at the hadassah university hospital will be collected prospectively from the electronic medical records. the occurrence of bleeding episodes or thrombotic events will be followed for the next 90 days following discharge from the hospital. the percent of patients actually treated by lmwh among patients entitled for such therapy according to the most updated international guidelines will be evaluated. the risk of minor and major bleeding will be compared among those given thromboprophylaxis and those who were not treated. similar comparison will be made for thrombotic events.

Eligibility criteria:
inclusion criteria: * patients admitted to the medical wards at the hadassah university hospital exclusion criteria: * none
randomized assessment of rapid endovascular treatment in basilar artery occlusion stroke in 115 hospital

Conditions: Stroke, Acute; Basilar Artery Occlusion

Summary: this is a prospective, open lable studies conducted in 115 hospital to compare between thromboectomy and recombinant tisue plasminogen activator only to evaluate the eficacy and safety of endovascular treatment in basilar artery occlusion stroke patients

acute basilar artery thrombosis is associated with a poor prognosis. prevalence of basilar artery occlusion are not known. although basilar artery occlusion has been reported in 2 per 1000 autopsy cases, basilar artery thrombosis may, in stroke registries, explain as many as 27% of ischemic strokes occurring in the posterior circulation.various treatments were tried in groups of patients with vertebrobasilar territory infarction but evidence based was not cleared previous studies. therefore, we conduct this study to evaluate the eficacy and safety of endovascular treatment in basilar artery occlusion stroke patients

Eligibility criteria:
inclusion criteria: * patients admit to 115 hospital in 24h of basilar artery occlusion stroke * nihss \> 4 points exclusion criteria: * patients refuse to participate in studies * patients with contraindication of either rtpa or thromboectomy

Keywords: ischemic stroke basilar artery occlusion
breast cancer screening with mri in women aged 50-75 years with extremely dense breast tissue: the dense trial

Conditions: Breast Cancer

Summary: the purpose of this study is to determine the cost-effectiveness of biennial screening with mammography and mri compared to mammography alone in women aged 50-75 years and who show \> 75% mammographic density.

women with very high mammographic density have a four to six fold higher breast cancer risk than women with low mammographic density. at the same time, the sensitivity of mammography is seriously impaired in women with high mammographic density, leading to many missed cases. nevertheless, in the netherlands this high risk group is currently screened between the age of 50 and 75 years with mammography only. mri is likely to lead to better detection of breast tumors in women with high mammographic density, because it has a much higher sensitivity than mammography. the dense trial investigates the additional value of mri for breast cancer screening in this risk group. participants with extremely dense breasts (acr4) and a negative mammogram are randomized to 'additional mri' (n=7,237) versus 'current practice' (n=28,948).

Eligibility criteria:
inclusion criteria: * dutch breast cancer screening participants, aged 50-75 years * \> 75% mammographic density * negative mammographic examination (birads 1 or 2) exclusion criteria: contraindications for mri * the presence of intracorporeal metals * adverse reaction to a (gadolinium-based) contrast agent in the past * severely impaired renal function (gfr \< 40 ml/min) * pregnant or lactating women * claustrophobia * adiposity (\> 150 kg)

Keywords: breast cancer breast neoplasm magnetic resonance imaging breast density early detection of cancer cancer screening test secondary prevention
brain gym exercises on risk of fall, balance and quality of life in obese subjects

Conditions: Obese Subjects

Summary: this study will be done to answer the following question: do brain gym exercises have an effect on risk of fall, static balance, dynamic balance and risk of fall and quality of life in obese subjects?

obesity has now become a severe and inescapable worry for people of all generations. obesity is associated with an excessive or inappropriate fat build-up that poses a health concern. a bmi of 25 or above is considered to be overweight, while a bmi of 30 is classified as obese. in 2017, nearly 4 million individuals died as a direct result of being overweight and obese, according to the global burden of sickness report. postural equilibrium is required for us to function normally in our daily lives. the ability to manage the center of mass inside the base of support, which serves to maintain the body in balance, is characterized as equilibrium. balance is described as the process of maintaining the body center of gravity within its support base, which necessitates regular modifications given by muscle activity and joint alignment . 1. thirty-two obese subjects from both gender with age ranging from 18-50 years old . and bmi ≥ 30 kg/m2. they will be selected from faculty of physical therapy kafr elshikh university group a (exprimental group): 16 subjects received brain gym exercises for 15-30 minutes per day, three times a week, for eight consecutive weeks . and traditional treatment in form of balance training included standing on one leg, standing in tandem mode, walking in a tandem mode (one foot in front of the other), walking on toes and heels, side walk, standing while one upper extremity and the opposite lower extremity were up, rotating the head from side to side, walking backwards for four steps, and shifting weight from one foot to the other. periodic exercises were frequently performed for 45 min for 3 sessions per week for 8 weeks group b (control group): 16 subjects will receive traditional treatment in form of balance training included standing on one leg, standing in tandem mode, walking in a tandem mode (one foot in front of the other), walking on toes and heels, side walk, standing while one upper extremity and the opposite lower extremity were up, rotating the head from side to side, walking backwards for four steps, and shifting weight from one foot to the other. periodic exercises were frequently performed for 45 min for 3 sessions per week for 8 weeks

Eligibility criteria:
inclusion criteria:1- obese subjects from both gender age range from 18-50 years old (cruz-gomez et al., 2021) 2- bmi ≥ 30 kg/m2 - exclusion criteria:neurological conditions affect the balance as: * alzheimer's disease * parkinson's disease * head injuries * peripheral neuropathy * headaches or migraines 2. lower limb injuries 3. postural hypotension 4. motion sickness 5. diabetes mellitus 6. pregnancy 7. rheumatoid arthritis 8. osteoporosis
validation of a novel robot-aided assessment of gait ability

Conditions: Spinal Cord Injury

Summary: the aim of this study is the validation of a novel gait assessment method implemented in the lokomat gait trainer with respect to established clinical gait assessment methods. the walking assessment method is based on the progressive reduction of the support of the device. the outcome measures of this algorithm will be the support needed in the different gait phases (guidance force of hip and knee joints) and the support required to the body weight support system (unloading). the hypothesis is that the guidance force and the support of the device will converge to a profile individual for each subject that is representative of one's impairment in the different gait phases. the reliability of the method will be tested collecting data from two sessions of lokomat training. the validity of the method will be tested comparing the outcome of the assessment task with established clinical walking assessment measures.


Eligibility criteria:
inclusion criteria: * individuals \>1 year post spinal cord injury or able bodied persons exclusion criteria: * presence of contraindications to lokomat training, inability or unwillingness to provide written informed consent or follow study procedures

Keywords: spinal cord injury adaptive control assessment assist-as-needed walking ability lokomat
ultrasound guided versus surgical rectus sheath block versus local anesthesia infiltration for postoperative analgesia in patients undergoing total abdominal hysterectomy

Conditions: Ultrasound; Surgical; Rectus Sheath Block; Local Anesthesia Infiltration; Postoperative Analgesia; Total Abdominal Hysterectomy

Summary: the aim of this work is to compare the efficacy and safety of the effectiveness and safety of ultrasound-guided surgical rectus sheath block and local anesthetic infiltration for postoperative analgesia in patients undergoing total abdominal hysterectomy.

total abdominal hysterectomy (tah) is a commonly performed major surgical procedure that results in substantial postoperative pain and discomfort. local anesthetic infiltration (lai) at the end of surgery is one of the most common technique employed in laparotomies for postoperative analgesia. rectus sheath block (rsb) has been used as a part of multimodal analgesia, especially when neuraxial techniques are unsuitable.the rsb was used to achieve peri-operative relaxation of the anterior abdominal wall.

Eligibility criteria:
inclusion criteria: * age from 18 to 65 years old. * american society of anesthesiologists (asa) physical status i - ii. * patients scheduled for elective total abdominal hysterectomy under general anesthesia. exclusion criteria: * hepatic, renal or cardiac disease. * any known allergy to local anesthetic. * physical or mental conditions which may vaguely measure postoperative pain following surgery. * history of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (nsaids) or central nervous system (cns) depressants as antiepileptic, and bleeding disorders.
randomized trial of alternative quadrivalent human papilloma virus (hpv) vaccination schedules in a university setting

Conditions: Human Papillomavirus Infection

Summary: this is a randomized, open label trial of hpv (human papilloma virus) vaccine, comparing an on-time administration of the third dose with delayed administration of the third dose. all participants would receive the first and second doses according to schedule. they would be randomized to either vaccine at 6 months or vaccine at 12 months. blood will be drawn for titers twice from all participants: pre-dose 1 and one month post third dose. we hypothesize that the gmts in the test group (t) are non-inferior to the usual timing control group (c): h0: δ ≤ -δ0 versus h1: δ \> -δ0 where δ = log (gmtt )- log (gmtc) and δ0 is the pre-specified non-inferiority margin.

the recommendations for hpv vaccine include catch-up of women 18 to 26 years old. given that a large percentage of women in this age group are attending college, a good place to access them would be through the student health services on college campuses. however, the hpv vaccine schedule of 0, 2, and 6 months is likely to be difficult to implement in a college calendar year and the immunogenicity of alternative schedules is unknown. if the immunogenicity of an altered schedule is good, then higher vaccination rates may be achievable. aims: 1. determine if delay in the third dose is immunologically non-inferior to the standard administration schedule (1 month post-dose 3). 2. determine the side effect profile of a delayed third dose, in comparison to the standard schedule

Eligibility criteria:
inclusion criteria: * 18-23 year old college females who are planning to return to the university for the next fall semester. exclusion criteria: * pregnancy or planned pregnancy. * prior receipt of hpv vaccine. * greater than four lifetime sexual partners. * immunosuppression. * anti-coagulant therapy. * breastfeeding. * history of abnormal pap smear. * allergy to vaccine components.

Keywords: human papillomavirus vaccine
phase 1 study to evaluate safety and antiviral activity of pbgene-hbv in adult patients with chronic hepatitis b

Conditions: HEPATITIS B CHRONIC

Summary: this is a phase 1, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pk, and antiviral activity of pbgene-hbv in adult participants with chronic hepatitis b.

refer to key inclusion and exclusion criteria.

Eligibility criteria:
key inclusion criteria: * male or women of non-child bearing potential * bmi 18.0 to 35.0 * good overall health deemed by the study investigator * chb infection documented at least 12 months prior to screening * hbeag-negative chb * must be virologically suppressed on current na treatment key exclusion criteria: * no history of cirrhosis of the liver * no current infections of hepatitis a, d, and e, human immunodeficiency virus (type 1 and 2), and no history of or current hepatitis c. in addition, no other active infections deemed clinically relevant. * no signs of hepatocellular carcinoma * not received an organ transplant * no malignancy within 5 years of screening, except for specific cancers that are cured by surgical resection (e.g., basal cell skin cancer) * no investigational agent received within 6 months of screening

Keywords: hepatitis b chronic gene therapy gene editing pbgene-hbv