Kornimate/medical-research-clean huggingface dataset:
extubation readiness study in very low birthweight infants

Conditions: Respiratory Distress Syndrome

Summary: the objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (vlbw) infants who are intubated for \>48 hours and have not yet been successfully extubated (extubated \>7 days).


Eligibility criteria:
inclusion criteria: * birthweight \>500g and\<1500g. * postmenstrual age \<34 weeks * mechanically ventilated \>48 hours * never successfully extubated exclusion criteria: * congenital heart disease (other than patent ductus arteriosus (pda), patent foramen ovale (pfo), and restrictive ventricular septal defect (vsd) * known or suspected airway anomalies * severe congenital malformations * need to remain intubated for other reasons (i.e. having surgery) * has met sbt criteria on previous calendar day (after 48 hrs of ventilation, pip≤18, peep≤6, fio2≤40%, rate≤30, ps≤8)
comparison of gas consumption from two different anesthesia machines

Conditions: Male Urogenital Diseases; Female Urogenital Diseases

Summary: low flow anesthesia (lfa) is used less than desirable, partly because one has considered that there might be danger of underdosing of anesthesia gas and thus risk of awareness under anesthesia.lfa has several advantages such as reducing loss of moisture and heat in the inhaled air under anesthesia and to reduce the consumption of anesthetic gas. a few anesthesia machines include an automatic gas control system: the aisys machine, by ge healthcare (madison, wi, usa), and the flow-i machine, by maquet (sweden). since these machines were introduced, only a few studies have reported their functionality and effect on gas consumption. 20 to 55% reduction of gas consumption was found. the potential reduction may have been underestimated because in the majority of cases a fgf higher than 1 l/min was still used. in this study the consumption of anesthetic gas (desflurane) delivered by two different anesthesia machines (aisys and flow-i) will be compared, with and without gas control delivery systems. gas consumption and the time needed to reach the target level of anesthetic gas concentration will be assessed. data needed will be collected directly from the anesthesia machine, picis ( electronic anesthesia record) and epj (electronic patient journal). the results of this study are of interest for intraoperative ventilation and of economic and ecological interest .


Eligibility criteria:
inclusion criteria: * patients undergoing robot assisted laparoscopic prostatectomy, robot assisted laparoscopic cystectomy or robot assisted laparoscopic gynecological surgery exclusion criteria: * cognitive failure, which compromises the ability for an informed consent. * pregnancy * american society of anesthesiologists physical status classification system (asa) iv-vi patients who are included in the study can be excluded for the following reasons: * surgical technical problems (for example surgically impossible to complete the operation with robot assisted surgery) * technical problems with the anesthesia machine

Keywords: anesthesia, inhalation laparoscopy prostatectomy cystectomy gynecologic surgical procedures
a survey of lanadelumab in participants with hereditary angioedema

Conditions: Hereditary Angioedema (HAE)

Summary: this study is a survey in japan of lanadelumab used to treat people with hereditary angioedema (hae). the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. the main aim of the study is to check for side effects related from lanadelumab and to check if lanadelumab improves symptoms of hae. during the study, participants with hae will take lanadelumab subcutaneous injection according to their clinic's standard practice. the study doctors will check for side effects from lanadelumab for 12 months.


Eligibility criteria:
inclusion criteria - participants diagnosed with hereditary angioedema (hae) and treated with lanadelumab for the first time. exclusion criteria - none

Keywords: drug therapy
endostar for locally recurrent nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: the purpose of this study is to determine whether endostar and imrt is effective in the treatment of locally recurrent nasopharyngeal carcinoma patients compared with imrt alone.

locally recurrent nasopharyngeal carcinoma (npc) may be salvaged by intensity modulated-radiotherapy (imrt), but severe late toxicities become the most common reason of death in imrt salvaged npc patients. the aim of this phase ii randomized controlled study is to address the efficacy of concurrent endostar (endostatins) with imrt to reduce the occurrence of severe late toxicities compared with imrt alone for locally recurrent npc patients.

Eligibility criteria:
inclusion criteria: 1. pathologically or clinically confirmed locally recurrent nasopharyngeal carcinoma; 2. no evidence of distant metastasis 3. more than 1 year from the end of the first course of radiotherapy 4. male, or female not in the phase of lactating or pregnancy 5. ecog 0-2 6. aged 18-70 years old 7. wbc count ≥4×109/l, neutrophile granulocyte count≥1.5×109/l, plt count ≥100×109/l, hb ≥9g/l 8. total bilirubin, ast, alt≤2.0 times of upper normal limits; creatinine ≤1.5 times of upper normal limits 9. written informed consort signed exclusion criteria: 1. only regionally recurrence 2. evidence of distant metastasis 3. prior invasive malignancy; noninvasive cancers (for example, carcinoma in situ of the bladder, oral cavity, or cervix are all permissible) are permitted 4. severe, active co-morbidity 5. prior anti-tumor treatment after diagnosis of local recurrence 6. mri was not performed 3 months after the first course of radiotherapy 7. abnormal function of heart, brain and lungs, etc 8. lactation or pregnancy 9. severe nasopharyngeal mucosal necrosis at the diagnosis of local recurrence

Keywords: endostar imrt recurrent npc
esp block versus wound infiltration for laminectomy

Conditions: Pain, Postoperative; Opioid Use; Anesthesia, Local; Surgery

Summary: spinal surgery is often burdened by perioperative pain and its treatment presently represents a challenge for anesthetists. an inadequate intra and postoperative analgesic therapy leads to a delay in the mobilization of the patients, prolonged hospital stay and thromboembolic complications, as well as the onset of chronic pain syndromes . effective pain treatment can help improve surgical outcome for patients undergoing spinal surgery. from the pathophysiological point of view pain in vertebral surgery can originate from different anatomical structures: vertebrae, discs, ligaments, dura mater, facet joints, muscles and skin-subcutis. the terminal innervation of these tissues originate from the dorsal branches of the spinal nerves, and this represents a target a multimodal approach to perioperative analgesia in vertebral surgery. systemically administered drugs such as nsaids, opioids, ketamine, intravenous lidocaine could benefit from the addition of locoregional therapies such as neuraxial blocks (anesthesia peridural or subarachnoid) or as shown more recently by other anesthesia techniques locoregional ultrasound-guided in recent years the anesthesiological interest has focused on the erector spinae plane block (espb). first described by forero et al, it is a paraspinal interfascial block targeting the dorsal and ventral branches of the spinal nerves just after their emergence from the spinal cord. in the ultrasound-guided technique the local anesthetic is injected between the deep fascia of the muscle itself and the transverse processes of the vertebrae at the level interested. the aim of this study is to evaluate the efficacy of espb when compared to wound infiltration in patients undergoing laminectomy


Eligibility criteria:
inclusion criteria: -planned 1 or 2 level surgical laminectomy exclusion criteria: * allergy to local anesthetics * refusal of consent * uncompensated cardiopathies, nephropathies, liver disease or peripheral neuropathies * hemopathies that predispose to bleeding * gastrointestinal ulcer or bleeding * local infection * psychiatric or neurological disorders (except those attributed to primary disease for which intervention is planned) history of abuse (or use in the 24 hours prior to surgery) alcohol addiction asa \> 3

Keywords: esp block laminectomy wound infiltration
istep - an mhealth physical activity and diet intervention for persons with hiv

Conditions: HIV/AIDS

Summary: hiv is associated with a pattern of neurocognitive deficits, metabolic dysfunction, and an elevated risk for cardiovascular disease (cvd), phenomena that remain untreated despite the use of medications to control the disease. this proposal will examine the effect of a personalized, automated, interactive mobile phone text message intervention (istep) designed to increase moderate physical activity (pa), decrease sedentary behavior (sb), and promote a healthy mediterranean-style diet (meddiet) in persons living with hiv (plwh). the investigators propose that participants who receive the istep intervention will increase the amount of physical activity, improve their diet, show a reduction in risk factors for cvd, and exhibit improved neurocognitive performance.


Eligibility criteria:
inclusion criteria: * ability to provide informed consent * hiv infection documented at the university of california, san diego (ucsd) hiv neurobehavioral research program (hnrp) or assessed by an hiv test at screening * proficient in english * physically capable of participating in moderate pa as screened by the physical activity readiness questionnaire * consent from primary care physician to participate in the study * able to consume walnuts - no nut allergies exclusion criteria: * any physical conditions that would prevent moderate physical activity or where moderate physical activity would represent a health risk for the individual, including a history of myocardial infarction or stroke * unwillingness or inability to participate in daily text messaging * tree nut allergy that would prevent walnut consumption or other food restrictions that would prevent participation in the mediterranean-style diet intervention (e.g., unable to eat fish or use olive oil for cooking).

Keywords: physical activity diet mhealth fitbit neurocognition text messaging
psychiatric disorder in anorectal dyssynergia

Conditions: Anorectal Disorder; Psychiatric Disorder

Summary: 1. evaluate psychiatric disorders among patients with anorectal dyssynergia 2. evaluate the effect of delayed diagnosis of anorectal dyssynergia on the quality of the life

functional constipation is a functional bowel disorder that presents as persistently difficult, infrequent, or seemingly incomplete defecation. subjective and objective definitions of constipation include: (1) straining, hard stools (hard, inspissated stool), unproductive calls ("want to but cannot"), infrequent stools, or incomplete evacuation. (2) \ 25% of the time dyssynergia defecation is common and affects up to one half of patients with chronic constipation. this acquired behavioral problem is due to the inability to coordinate the abdominal and pelvic floor muscles to evacuate stool the etiology of dyssynergic defecation is unclear however it was found that the problem began during childhood in 31% of patients, and after a particular event, such as pregnancy, trauma, or back injury in 29% of patients, and there was no cause in 40% of patients. the first step in making a diagnosis of dyssynergic defecation is to exclude an underlying metabolic or pathologic disorder .a detailed history, prospective stool diaries, and a careful digital rectal examination will not only identify the nature of bowel dysfunction, but also raise the index of suspicion for this evacuation disorder. anorectal physiology tests and balloon expulsion test are essential for a diagnosis. newer techniques such as high-resolution manometry and magnetic resonance defecography can provide mechanistic insights. . anorectal dyssynergia impact quality of life and cause psychiatric problems such as of anxiety, depression, obsessive compulsiveness, psychoticism, and somatization. so, the investigators aim to evaluate psychiatric disorders among those patients and impact of delayed diagnosis on their quality of life.

Eligibility criteria:
inclusion criteria: * patients diagnosed as anorectal dyssynergia with anorectal manometric study exclusion criteria: * patient with diabetes mellitus ,hypertension ,chronic kidney disease ,and chronic liver disease patients * patient with neurological disease * patient with thyroid disease * patient with past history of psychiatric disorders * patients with past or current medications or substance induced psychiatric disorders
psychosocial, environmental, and chronic disease trends in puerto rico

Conditions: Heart Diseases; Type2 Diabetes; Hypertension; Obesity; Dyslipidemias; Metabolic Syndrome; Cardiovascular Diseases; Chronic Disease; Inflammation; Psychological Stress; Physiological Stress; Depressive Symptoms; Coping Behavior; Diet Habit; Lifestyle; Food Insecurity

Summary: the overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing cardiovascular-related disparities in puerto rico. to this end, investigators will establish 'prospect: puerto rico observational study of psychosocial, environmental, and chronic disease trends', an island-wide, longitudinal population cohort of 2,000 adults (30-75 years) in pr recruited with a community-wide sampling strategy, and assessed in a network of several partner clinics across the island. the study will collect comprehensive data on multiple psychosocial, dietary, and food-related factors, cvd biological markers, and medical record data, with follow-up at 2-years, and will assess variations by urban-rural area and by timing before-after maria.


Eligibility criteria:
inclusion criteria: 1. age 30-75 years old at the time of enrollment 2. non-institutionalized 3. living in pr at the time of the first interview and the year before and not planning to move from the island within 3 years 4. able to answer questions without assistance 5. living in a stable dwelling exclusion criteria:

Keywords: hispanics/latinos minority health puerto rico cardiovascular disease cardiometabolic health chronic disease risk factors disaster research caribbean and latin america population health prospective study allostatic load food insecurity longitudinal study
a dose escalation study of the safety and pharmacokinetics of gsk1363089 (formerly xl880) administered orally to subjects with solid tumors

Conditions: Solid Tumours

Summary: this clinical study is being conducted at two sites to determine the optimum dose, safety, and tolerability of gsk1363089 treatment in adults with solid tumors. this study is no longer recruiting subjects.


Eligibility criteria:
inclusion criteria: * histologically confirmed solid tumor which is metastatic or unresectable with no known effective treatment measures, * ecog performance status of \</= 2. * adequate bone marrow reserve, hepatic, renal, and cardiovascular function, * negative pregnancy test. exclusion criteria: * chemotherapy within 4-6 weeks of the start of treatment, * radiotherapy within 4 weeks of the start of treatment, * known brain metastasis, * uncontrolled medical disorder such as infection or cardiovascular disease, * hiv positive, * pregnant or breastfeeding women

Keywords: met inhibitor c-met xl880 gsk1363089 solid tumors
the effects of hydration on gut health and thinking

Conditions: Dehydration; Cognitive Change; Gastrointestinal Microbiota

Summary: the central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.

a single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (f) or 2.5(m) liters per day which is approximately 70% of the ai for daily water consumption. pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.

Eligibility criteria:
inclusion criteria: * 19-50 years of age * 18.5-34.49 kg/m2 * 24-hour uosm above 500 mosm/kg * no antibiotic use over the past 3 months * absence of metabolic diseases and use of diuretics * agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention * avoid consuming prebiotic and probiotic supplements during study participation * not pregnant * agree to follow the study protocol exclusion criteria: * \ 50 years of age * \ 34.49 kg/m2 * 24-hour uosm \<500 mosm/kg * antibiotic use over the past 3 months * metabolic diseases and use of diuretics * not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the * intervention * not agree with avoiding consuming prebiotic and probiotic supplements during study participation * pregnant * not agree to follow study protocol
a study of music therapy to support intrauterine insemination

Conditions: Intrauterine Insemination

Summary: the purpose of this research is to learn if playing music in the room during an intrauterine insemination procedure decreases anxiety and pain for patients at the time of the procedure.


Eligibility criteria:
inclusion criteria: * iui must be performed in the reproductive endocrinology and infertility offices at mayo clinic in rochester. * iui procedure must be on a weekday. * iui procedure is scheduled to be completed by a nurse in the rei department. exclusion criteria: * not english speaking. * iui procedure on a weekend day. * iui procedure is scheduled with an md provider (known or expected to be difficult). * planned iui procedure is cancelled prior to undergoing the procedure. * the patient has a documented diagnosis of complete hearing loss or significant hearing impairment in both ears. * the patient has previous participated or declined enrollment in the study during a prior iui procedure.

Keywords: music therapy
treatment of complicated parapneumonic effusion with fibrinolytic therapy versus vats decortication

Conditions: Parapneumonic Effusion; Empyema, Pleural; Coagulopathy

Summary: this study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early vats (video assisted thorascopic surgery) decortication versus fibrinolytic therapy. during treatment, the patient's coagulopathy status will also be evaluated.

the treatment of parapneumonic infections (infection in the pleural space) at the denver health medical center is not standardized, and timing for advanced interventions such as fibrinolytic therapy or surgical decortication remain unclear. the definitive treatment strategy in these patients may be sub-optimal, and lead to prolonged hospitalization and morbidity. this is concerning as the mortality rate of community acquired pneumonia triples in the presence of a parapneumonic process (5-15%) and can reach over 25% if it becomes bilateral(1). prompt recognition of pleural space infections is essential for reducing morbidity and mortality. this is attributable to the progression of the disease from a simple fluid collection amenable to pleural space drainage, to necrotizing empyema requiring thoracotomy decortication and open drainage. the keys to management of parapneumonic effusions are early diagnosis, appropriate therapeutic intervention, and recognition of failure of conservative management. the investigators propose that a standardized pathway for identifying and treating parapneumonic effusions will be an important quality improvement. a key gap in the literature remains if patients with parapneumonic infections that cannot be drained with a chest tube should undergo a trial in intrapleural fibrinolytic therapy, or if they should go directly to video assisted thoracic surgery (vats) for decortication of all infectious material.

Eligibility criteria:
inclusion criteria: * 18 years old and older * admitted with pleural effusion that undergoes thoracentesis by medical/pulmonary service * pleural fluid ph \<7.3 * sicu placed chest tube * subsequent transfer to sicu exclusion criteria: * existing malignancy * malignant cells from initial pleural fluid sample * end stage liver disease (child's b or greater) * coagulopathy * unable to tolerate surgical procedure * frank purulent drainage (needs or regardless) * recent surgery of abdomen or thorax precluding the use of tpa * baseline neurologic impairment requiring a proxy for consent

Keywords: vats decortication surgical pleural decortication fibrinolytic therapy pneumonia thoracostomy
study to evaluate the effects of single ascending oral doses of acd856 on safety, tolerability and pharmacokinetics

Conditions: Alzheimer Disease; Cognition Disorder

Summary: the sad design of the study is based on the aim to study safety, tolerability and pk of selected doses of acd856 in a limited number of healthy volunteers. acd856 will be administered orally.


Eligibility criteria:
inclusion criteria: * signed and dated informed consent prior to any study-mandated procedure.´ * willing and able to comply with study requirements. * healthy males and healthy women of non-childbearing potential aged ≥18 and \<65 years at screening. * bmi ≥18.0 and ≤30.0 kg/m2 at screening. * males and females of non-childbearing potential may be included in the study. male subjects must be willing to use condom or be vasectomized or practice sexual abstinence to prevent pregnancy and drug exposure of a partner and refrain from donating sperm from the date of dosing until 3 months after dosing with the imp. * clinically acceptable medical history, physical findings, vital signs, ecg and laboratory values at the time of screening, as judged by the investigator. exclusion criteria: * planned treatment or treatment with another investigational drug within 3 months prior to randomization. * positive screen for drugs of abuse or a positive alcohol result at screening or admission to the clinic. * clinically relevant findings in laboratory parameters, ecg or vital signs at screening * current smokers or users of nicotine products. * history of alcohol abuse or excessive intake of alcohol. * presence or history of drug abuse. * history of, or current use of, anabolic steroids. * excessive caffeine consumption. * plasma donation within one month of screening or blood donation prior to screening.

Keywords: cognition disorder alzheimer's disease