effect of tactile/kinaesthetic massage therapy on dxa parameter of preterm infants

Conditions: Preterm Infant; Body Composition; Dual X-ray Absorptiometry (DXA) Scan

Summary: the effect of tactile/kinaesthetic massage therapy on weight gain and different components of growth, as assessed by anthropometric measurements and dxa scan, and correlate these components with serum igf-1, leptin and adiponectin in preterm infants.

prospective open label randomized, single-blind, controlled trial was done in the nicu at mansoura university children's hospital. stable preterm infants in the nicu awaiting for sustained pattern of weight gain were included in the study. massage therapy was started at corrected gestational age of 35 weeks and continued for 5 consecutive days. the protocol of massage therapy was performed as been described by tiffany field. three consecutive, 15 minutes, sessions were performed daily after the noon feeding. each treatment session was divided into 5 minutes of tactile stimulation, followed by 5 minutes of kinaesthetic stimulation, and then another 5 minutes of tactile stimulation. during massage therapy, infant's behavioural reaction was observed for signs of distress (e.g., yawning, finger splaying, crying). vital signs are measured 15 minutes before, 15 minutes during and 15 minutes after the massage procedure. if signs of physiologic distress developed (heart rate greater than 200 bpm), massage was discontinued for 15 seconds, or until a return to baseline levels. the study was discontinued if five periods of observed behavioural or physiological stress occurred. body composition assessment using dxa scan was performed for total body all infants were studied on one occasion by the end of 5 days massage therapy. dxa scan was performed without sedation but a pacifier with non-metallic parts was used as needed. the scanning procedure was interrupted if movement artefacts is noted. in addition, analyses of different body regions were also performed. regional analyses typically involved the head, each of the four extremities, and the trunk. blood samples were collected using standard technique at baseline and after 5 days for measurement of igf-1, leptin and adiponectin levels using enzyme-linked immunosorbent assay \[elisa kit supplied by elabscience biotechnology (no.1 shizishan street, wuhan, hubei, china) catalog no: e-el-h0086\]. randomization infants were assigned randomly, by a designated neonatologist, to treatment groups using internet based random table technique with cards in opaque sealed envelopes that were kept in the neonatal care unit. a written informed consent was obtained from the parents of each infant upon enrolment in the study. procedures of mt, dxa scan, and laboratory analysis were performed by a designated personnel throughout the study to ensure consistency. performers of dxa scan and laboratory measures were blinded to groups of intervention.

Eligibility criteria:
inclusion criteria: * medically stable premature infants with gestational age at 28 to 37 weeks' admitted to the "grower" (step-down) nursery. stability is defined as lack of need for supplemental oxygen, apneas and bradycardias, systemic antimicrobial therapy for infection, or a central line. on at least 100 ml/kg/d of feed (oral or tube feed) preterm formula. informed consent will be obtained from parents before enrollment in the study. exclusion criteria: * history of necrotizing enterocolitis, receipt of postnatal steroids, active infection, congenital malformations, chromosomal abnormality, intracranial hemorrhage more than (\>) grade 2, inborn errors of metabolism, meningitis or encephalopathy, need for surgery.