Kornimate/medical-research-clean huggingface dataset:
mitigating heat stress among rickshaw drivers in bangladesh

Conditions: Core Temperature; Telomere Length, Mean Leukocyte; Kidney Function Issue

Summary: the goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign half of them to receive battery-powered rickshaws to use for four months. investigators will assess how this change impacts their core body temperature while they work, the length of their telomeres (caps on the end of dna that are associated with aging), and kidney function.

personal exposure to heat may be elevated above ambient temperatures if an individual is very active (which generates metabolic heat) or wears clothing that prevents cooling. age can influence the consequences of heat stress. older adults are at elevated risk of adverse impacts from heat stress due to their reduced ability to dissipate heat. heat stress is particularly high among outdoor workers. south asia has millions of bicycle rickshaw drivers, who use their muscles or battery power to pull hundreds of pounds of passengers and goods on modified bicycles. when manual rickshaw drivers rest to cool off, they reduce their already meager income. heat stress not only threatens their livelihoods and thereby their right to an adequate standard of living but also their right to work, given that they have few employable skills other than manual labor. south asia faces the greatest current and predicted loss in disability-adjusted life years due to heat stress, and heat stress is particularly strong in informal settlements. as such, the investigators plan to conduct this study in dhaka, bangladesh. the overall hypothesis is that driving a battery-powered rickshaw will reduce heat strain. the investigators will evaluate the impact of driving a battery-powered rickshaw on core temperature (primary outcome), telomere length, kidney function, heart rate, heart rate variability, sleep quality, self-reported thermal comfort, mental health, wellness, and fatigue (secondary outcomes).

Eligibility criteria:
inclusion criteria: * reports driving a manual rickshaw at least five days per week for at least 8 hours per day for the past 12 months exclusion criteria: * reports driving a battery-powered rickshaw in the past 12 months * has hypertension, as measured by our study staff * has diabetes, as measured by our staff * reports diagnosis with cardiovascular disease / chronic cardiac condition * reports diagnosis with respiratory disease / chronic respiratory condition

Keywords: heat stress heat strain rickshaw heart rate heart rate variability sleep quality bangladesh
the effect of positioning with material and hand-face maneuver

Conditions: Stress; Position

Summary: the study was administered in a randomized controlled experimental design to evaluate the effects of material positioning and hand-face maneuver on physiological parameters and stress symptoms in preterm newborns with gestational weeks 28 to 32. the sample of the study consisted of 60 preterm infants who met the selection criteria in newborn intensive care unit between september 2018 and july 2020.the newborns in the control group (n=30) were given a "nesting with a rolled up blanket" position, as in the routine of the ward. the experimental group1 (n=30) was given positions using a "positioner" and the same newborns (experimental2) was given positions using "positioner and hand-face maneuver" on the second day of the study.

the universe of the study consisted of preterm newborns patients who met the selection criteria in newborn intensive care unit.the research was planned as a randomized controlled experimental study. in order for the groups to be distributed homogeneously, the order produced by a computer program (http://www.randomizer.org/) was used. patients who meet the inclusion criteria and agree to participate in the study assigned to the experimental and control groups according the randomization list. the control variable of the study is demographic characteristics of the baby. the dependent variables of the study are physiological parameters, newborn position assesment tool score and newborn stress scale score in the research, "information and follow-up form" prepared by the researcher in line with the literature was used as data collection tools. newborn position assesment tool and newborn stress scale were also used

Eligibility criteria:
inclusion criteria: * preterm newborn between 28-32 weeks of gestation (very early preterm) * not connected to mechanical ventilator * parent's consent with informed consent form exclusion criteria: * presence of congenital anomalies, a known infection, neuromuscular problems and genetic anomalies in a preterm newborn * have undergone any surgical intervention * painful procedure (invasive procedure, etc.) performed in the last hour * taking analgesics in the last six hours

Keywords: preterm position stress physiological parameters
safety and intraocular pressure (iop) lowering efficacy of low dose travoprost

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to compare the safety and iop-lowering efficacy of various low dose travoprost formulations in patients with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older, either sex or race with open-angle glaucoma or confirmed ocular hypertension * other protocol-defined inclusion criteria may apply exclusion criteria: * age related * other protocol-defined exclusion criteria may apply
prospective, multicenter, randomized controlled, non-inferior clinical study to evaluate the safety and efficacy of radiofrequency transseptal puncture system in atrial septul

Conditions: Evaluation of the Radiofrequency Transseptal Puncture System; Atrial Septum Puncture

Summary: to evaluate the safety and efficacy of radiofrequency transseptal puncture system and its auxiliary radiofrequency puncture device in atrial septum. evaluation indicators: success rate of atrial septum; the time required to successfully complete the atrial septum; rate of failed atrial septal puncture crossing to the contralateral group; performance evaluation of an rf transseptal puncture system; the incidence of complications related to atrial septal puncture; rates of adverse events; rates of serious adverse events.


Eligibility criteria:
inclusion criteria: participants scheduled to undergo transseptal access interventional cardiology procedure; the subjects were informed of the nature of the study, understood the purpose of the clinical trial, voluntarily participated and signed an informed consent form. exclusion criteria: 1. the presence of an intracardiac mass, thrombus or vegetation on echocardiography; left atrial myxoma; 2. subjects with asd occluder or patch implantation; 3. hemorrhagic or coagulopathy; or there is contraindication to antithrombotic drugs; 4. acute myocardial infarction within 4 weeks; 5. end-stage heart failure (acc/ahad stage); or after heart transplantation; or waiting for a heart transplant; 6. history of cerebrovascular accident within 30 days; 7. pregnant and lactating women; 8. acute systemic infection or sepsis; 9. patients who have participated in any drug and/or medical device clinical trial within 1 month before this trial; 10. atrial septal puncture within 3 months; 11. life expectancy less than one year; 12. the investigator judged that the patient had poor compliance and could not complete the study according to the requirements; or other circumstances in which the researcher considers the subject to be unsuitable for the study
baduanjin exercise on meridian energy, lung function and heart rate variability in patients undergoing lung operative.

Conditions: Lung Cancer Non Small Cell

Summary: lung cancer (lc) is the leading cause of cancer-related death and is the most frequent cancer in both sexes.respectable lung tumor with abnormal lung function, usually because of tobacco use, have chronic obstructive pulmonary disease (copd), coronary artery disease, and/or old age as underlying comorbidities. until recent, most exercise prescribed using aerobic exercise programs. baduanjin is a type of movement-based mind-body intervention. it is a form of traditional practice designed to promote physical and psychological health, manage symptoms, and relieve stress during illness. the impacts of a baduanjin exercise-based cardiopulmonary rehabilitation program for patients recovering from respectable lung tumor on meridian energy analysis device (mead100, med- pex enterprises, taichung, taiwan), lung function and heart rate variability has yet to be assessed. this trial evaluates whether the baduanjin exercise would provide effective lung function, meridian energy and hrv in patients following lung operative.


Eligibility criteria:
inclusion criteria: * diagnosis of primary nsclc based on preoperative pathologic examination * had no surgical contraindication to and were willing to undergo video-assisted thoracic surgery or traditional thoracotomy (open) lobectomy * agreed to receive exercise performed. exclusion criteria: * spo2 \<90% during the 6-min walking test * with an absence of nsclc, as confirmed by postoperative pathologic examination or with sub-lobar resection or pneumonectomy
androgen-deprivation therapy and cardiovascular risk: a nationwide population-based cohort study

Conditions: Prostate Cancer; Androgen-deprivation Therapy

Summary: the research focuses on the safety profile of androgen-deprivation therapy (adt). the hypothesis is that safety issue, as regards to cardiovascular risk, is not homogenous across the spectrum of androgen-deprivation therapy modalities. our study will encompass all adt modalities including intermittent adt. adt is a cornerstone therapy in prostate cancer management. decisions about adt should weigh improvements in cancer-specific outcomes against potential increased risks for cardiovascular diseases. the potential for harm from adt should be more precisely defined according to the type of adt. those potential risks underscore the importance of better understanding benefits of adt, especially in contexts where data are still lacking.adt is also indicated in sexually deviant behavior.

our study is a nationwide population-based prospective cohort on 4 years thanks to the french health reimbursement agency database (système national d'information inter-régimes de l'assurance maladie, sniiram) and french hospital discharge database (programme de médicalisation des systèmes d'information; pmsi). a unique civil registration number has been assigned to all french residents and this number unambiguously links those two databases.

Eligibility criteria:
inclusion criteria: * adults men, age greater 18 years, * affiliation to french health system, * diagnosis of prostate cancer * at least one dispensation (leading to a reimbursement claim) in a 1.5 year period of an androgen-deprivation therapy or a hospitalization for orchiectomy. exclusion criteria: * orchiectomy for another reason that prostate cancer. * patients treated with both gonadotropin releasing hormone agonists and bilateral orchiectomy will be excluded from analyses.

Keywords: androgen-deprivation therapy prostate cancer nationwide population-based cohort myocardial infarction ischemic stroke
barriers to treatment in obese adolescents

Conditions: Obesity

Summary: the purpose of this study is to identify significant racial and ethnical differences in risk factors for development of obesity and weight loss in adolescents in central virginia

* participation for 6 months in a program incorporating exercise, nutritional counseling and behavioral support leads to measurable improvements in overall fitness, metabolic indicators and loss of body fat for obese adolescents. * degree of loss of body fat, improved overall fitness and improvements in metabolic indicators can be correlated with the degree of compliance and participation for 6 months in the program. * parental involvement and support can be correlated with the degree of compliance and participation in the program. * socioeconomic factors can be correlated with the degree of compliance and participation in the program. * cultural differences in diet, attitudes toward body shape, and family dynamics can be correlated with success or failure in a weight loss program. * individual differences in self-esteem, self-discipline and feelings of connectedness with family members can be correlated with success or failure in a weight loss program.

Eligibility criteria:
inclusion criteria: * age 11-18 * above 95th percentile for weight * reside within 30 miles of program site * ability to comprehend basic instructions * ability to perform basic exercise movements exclusion criteria: * having a metabolic disorder that causes weight gain * having a cognitive deficit that impacts learning and comprehension * having a physical defect that prevents exercise

Keywords: pediatric overweight, african american; adolescent; intervention, teasing; self-esteem quality of life metabolic syndrome insulin resistance diabetes nutrition motivation culture bmi cardiorespiratory fitness resistance training compliance
cognitive fitness for depression in older adults

Conditions: Depression Mild; Depressive Disorder, Major; Mild Cognitive Impairment

Summary: this research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. the investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (mri).

major depression in the elderly is both challenging to treat and detrimental to the cognitive functioning of patients. major depression increases the probability of a later dementia diagnosis. by targeting cognitive processes in treatment, the investigators hope to both find a more effective means to manage major depression in older adults, but also demonstrate how top-down processes (e.g., executive control network) may be driving depression and cognitive decline in older adults. the investigators are recruiting older adults with and without mild cognitive impairment. all subjects must have at least mild depressive symptoms to be eligible to participate. subjects will be randomly assigned to one of two different interventions. results of this study will help the investigators understand the mechanisms that contribute to depressed mood and cognitive change in older adults with late life depression.

Eligibility criteria:
inclusion criteria: * ability to read and write in english * current major or mild depression despite ongoing treatment * under the care of a physician who prescribes medication for depression * currently treated with an antidepressant for at least 8 weeks exclusion criteria: * psychosis * other psychiatric disorders (except personality \& generalized anxiety disorders) * substance use disorders in the prior year * clinical diagnosis of dementia * neurological disorders (e.g., stroke, epilepsy, brain injury with loss of consciousness \> 30 minutes, brain tumors, demyelinating diseases) * corrected visual acuity \< 20/70 or color blindness
mk-0941 multiple dose study in japanese patients with type 2 diabetes (mk-0941-011).

Conditions: Diabetes Mellitus, Non-Insulin-Dependent

Summary: the multiple dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of mk-0941 in japanese patients with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * japanese male or female between 20 to 65 years of age * diagnosis of type 2 diabetes * patient being treated by diet and exercise alone exclusion criteria: * patient has a history of type 1 diabetes * patient is being treated with glaucoma medications * patient has donated blood or participated in another clinical study in the past 12 weeks * patient is a regular user of any illicit drugs or has a history of drug, including alcohol, abuse
study of arimoclomol in inclusion body myositis (ibm)

Conditions: Inclusion Body Myositis

Summary: funding source - fda office of orphan products development (oopd). the purpose of this study is to evaluate the safety and efficacy of the study drug, arimoclomol in ibm patients.

a phase 2/3, randomized, double-blind, placebo-controlled, international, 20-month intervention study in patients with ibm.

Eligibility criteria:
inclusion criteria: * meet any of the european neuromuscular centre inclusion body myositis research diagnostic criteria 2011 categories for ibm. * demonstrate being able to arise from a chair without support from another person or device. * able to ambulate at least 20 ft/6 meters with or without assistive device. once arisen from the chair, participant may use any walking device, i.e. walker/frame, can, crutches, or braces. they cannot be supported by another person and cannot use furniture or wall for support. * age at onset of weakness \>45 years. * body weight of \>= 40 kg. * able to give informed consent. exclusion criteria: * history of any of the following excludes subject participation in the study: chronic infection particularly hiv or hepatitis b or c; cancer other than basal cell cancer less than five years prior; or other chronic serious medical illnesses. * presence of any of the following on routine blood screening: white blood cells (wbc) \ 30 mg/dl; creatinine \>1.5 x upper limit of normal; symptomatic liver disease with serum albumin \<3 g/dl. * history of most recent creatine kinase \>15x the upper limit of normal without any other explanation besides ibm. * history of non-compliance with other therapies. * use of testosterone except for physiologic replacement doses in case of androgen deficiency. participants must have documented proof of the androgen deficiency. * coexistence of other disease that would be likely to affect outcome measures * drug or alcohol abuse within past three months. * participation in a recent drug study in the last 30 days prior to the screening visit or use of a biologic agent less than 6 months prior to the screening visit. * women who are lactating or unwilling to use adequate method of birth control who are not surgically sterile. adequate birth control includes use of intrauterine device, abstinence, or oral contraceptives or a double barrier method, e.g condom plus diaphragm will be necessary for both male and female participants. * participants taking \>7.5 mg prednisolone or equivalent or participants on intravenous immunoglobulin therapy (ivig) or other immunosuppressants within the last 3 months. * clinically significant renal or hepatic disease, as indicated by clinical laboratory assessment.

Keywords: ibm
k1-70 - a study in subjects with graves' disease

Conditions: Graves' Disease

Summary: this study is the first time that k1-70 will be administered to humans. the principal aim of this study is to obtain safety and tolerability data when k1-70 is administered as an im injection or as an iv infusion to subjects with graves' disease. current therapy for graves' disease includes treatment with anti-thyroid drugs, destruction of the thyroid using radioiodine, or total surgical thyroidectomy. beta-blockers and calcium antagonists may be used to control some of the symptoms of hyperthyroidism. k1-70 is a thyroid stimulating hormone receptor antagonist that may provide new in vivo diagnostic and therapeutic tools for the management of patients with graves' disease, patients with thyroid cancer and patients who would benefit from controlling receptor activity.

graves' disease is one of the most common overt autoimmune disorders. patients with graves' disease have thyroid over activity and hyperthyroidism. symptoms of hyperthyroidism include goitre, fatigue, heat intolerance, sweating, weight loss despite good appetite, shakiness, inappropriate anxiety, palpitations of the heart, shortness of breath, tetchiness and agitation, poor sleep, thirst, nausea and increased frequency of defaecation. the rationale of this study is to obtain safety and tolerability data when k1-70 is administered as an intramuscular injection or as an iv infusion to subjects with graves' disease. this information, together with the pharmacokinetic data, will help establish the doses and dosage regimen suitable for repeat administration to patients. this is an open-label study. the expected duration of each subject's participation in the study is approximately 18 weeks (including a screening period of up to 4 weeks).

Eligibility criteria:
main inclusion criteria: * age 18-75 years * have graves' disease and are being treated with anti-thyroid medications or not treated with anti-thyroid medications (due to side-effects) and who are clinically and biochemically euthyroid or hyperthyroid * have a body mass index (weight \[kg\]/height \[m\]2) between 18.5 and 35.0 kg/m2 main exclusion criteria: * current or chronic history of liver disease * history of cancer within the last 5 years except localised skin cancer * graves' orbitopathy with clinical activity score \>3/7 * evidence of optic neuropathy and/or corneal breakdown * significant systemic infection * history of recurrent or current infection * splenectomy * recently had major surgery or plan major surgery * had thromboembolic event due to a blood clot in the last 12 months * have clinically significant laboratory tests * a clinically significant allergic condition (excluding hay fever) * currently receiving corticosteroids * smoke more than 10 cigarettes (or its equivalent in nicotine (including use of e-cigarettes)) per day * history of drug abuse
comparing the effect of different intracanal dressing on failed root canal treated cases on periapical healing

Conditions: Periapical Disease

Summary: the goal of this clinical trial is to compare the effects of different intracanal medication between endodontic retreatment visits in previously failed root canal treatment patients (single root canal anteriors or premolars teeth). the main question it aims to answer are: * is natural and synthetic intracanal medicament effective in reducing or complete healing of periapical lesions or not? the researchers will compare the effect of different intracanal dressing including: * nanocurcumin gel * curcumin gel * ciprofloxacin +ibuprofen gel * calcium hydroxide paste as control group in between the endodontic retreatment visits to see if these medicaments work well on periapical lesion healing this outcome measured by cone beam ct at base and after 1 year follow up period


Eligibility criteria:
inclusion criteria: * medically free patients * both sex includes male and females * patients age between 20-60 * patients agreement positively to share in the study * patient able to sign informed consent * on clinical and radiographic examinations, the included teeth maxillary and mandibular single root canal anteriors or premolars suffering from failed endodontic treatment with periapical lesion exclusion criteria: * badly broken down teeth indicated for extraction or with difficult isolation * teeth with former procedural errors as ledge, perforation or instrument separation * medically compromised patients * patients with history of receiving antibiotics within a month before starting study * periodontally affected teeth by pocket depth \& \> 4mm