Kornimate/medical-research-clean huggingface dataset:
atrial fibrillation, cardiac symptoms, and anxiety

Conditions: Atrial Fibrillation; Anxiety

Summary: this is an investigation of a mindfulness and interoceptive exposure intervention in patients with atrial fibrillation, to decrease anxiety sensitivity, symptom burden, and atrial fibrillation recurrence.

patients with atrial fibrillation (af) have a poorer quality of life and have elevated rates of anxiety. higher anxiety and somatization has been associated with more severe af symptoms. increased anxiety symptoms have also been associated with increased medical visits for af management. some studies show that anxiety may increase the risk of af recurrence following medical intervention, including increasing af recurrence after circumferential pulmonary vein ablation. growing evidence suggests a pressing need to treat anxiety and improve quality of life among af patients, yet few data exist about how to accomplish this. mindfulness-based behavioral treatments offer promise in this regard. interoceptive exposure (ie) is an evidence-based cognitive behavioral intervention to address intolerance of anxiety-related physical sensations, commonly seen in panic disorder and other anxiety disorders. it involves systematically and repeatedly inducing feared physical sensations to promote increased tolerance and reduced distress associated with these symptoms. mindfulness is defined as paying attention to the present moment in an open and nonjudgmental way. mindfulness-based behavioral interventions have been successfully applied in various psychiatric and medical patient populations, including cardiac patients. two meta-analyses suggest that mindfulness-based interventions are moderately effective for reducing distress related to physical or psychosomatic illnesses. the investigators of this study hypothesize that a mindfulness and ie intervention will decrease anxiety, af symptoms and af recurrence, and will improve quality of life among patients with af. this is a pilot, prospective trial of a mindfulness and ie intervention in patients with af. the mindfulness and ie intervention will be delivered in four to five, manualized, individual sessions.

Eligibility criteria:
inclusion criteria: * male or female outpatients * at least 18 years of age * clinical diagnosis of atrial fibrillation * literacy and fluency in english * ability to return to the hospital for study visits * score ≥ 24 on the anxiety sensitivity index-3. exclusion criteria: * medical co-morbidity sufficient to confound the outcome variables * medical co-morbidity for which the experimental treatment is contraindicated * clinically significant cognitive impairment * known unavailability for follow-up in the ensuing 3 months
low dose icg for biliary tract and tumor imaging

Conditions: Cholecystitis; Hepatocellular Carcinoma; Liver Metastases

Summary: near-infrared fluorescence (nirf) imaging after an intravenous injection of indocyanine green (icg) allows for the intraoperative identification of liver anatomy. the investigators have new data that a much lower dose improves this visualization. confirmation of this hypothesis would mean that icg can be administered on the same day of surgery in order to augment real-time intraoperative visualization, thereby providing a safe, feasible, and cost-effective strategy for the surgical treatment of liver disease.

the investigators have a series of surgical cases in which the investigators have been able to achieve excellent intraoperative biliary visualization with a greatly decreased (50-200 fold lower) dose of icg than the previously published dose. furthermore, this decreased dose was visible in about 15-20 minutes from the time of injection with low liver background fluorescence, a significant improvement that would make its utilization in the operating room more practical. the investigators hypothesize that a lower dose will: 1) allow adequate visualization of the extrahepatic biliary tree, including the cystic, common hepatic, and common bile ducts. confirmation of hypotheses would mean that a lower dose of icg can be administered on the same day of surgery in order to augment real-time intraoperative localization of the extrahepatic biliary tree, thereby providing a safe, feasible, and cost-effective strategy for the surgical treatment of liver disease. the investigators intend to test our hypothesis with the following specific aims: aim 1: to compare the efficacy and utility of a low dose icg (0.05 mg) protocol with a previously published dose (2.5 mg) in imaging the extrahepatic biliary tract.

Eligibility criteria:
inclusion criteria: * patients undergoing standard of care laparoscopic hepatic or biliary operations or patients undergoing standard of care laparoscopic resection for hepatic tumors: hepatocellular carcinoma or metastatic tumor exclusion criteria: * patients with a history of adverse reactions or known allergy to icg, iodine, or iodine dyes and pregnant and/or lactating patients.

Keywords: biliary tract indocyanine green (icg) tumors near-infrared fluorescence
prevision® pmcf study

Conditions: Survival, Prosthesis

Summary: monocentric, non-interventional post-market clinical follow-up (pmcf) study on past implantations of the prevision® prosthesis; the survival rate of the prevision® prosthesis shall be evaluated and compared to literature results on comparable revision stems.


Eligibility criteria:
inclusion: * patient received a prevision® hip stem (curved or straight) between 2002 an 2012 * patient gave his written consent for study participation exclusion: - none

Keywords: hip arthroplasty revision arthroplasty survival
pathobiomes in gut of critically ill patients

Conditions: Pseudomonas Aeruginosa

Summary: despite powerful antibiotics, 50% of the intestinal tracts of critically ill surgical patients are colonized by pseudomonas aeruginosa, whose mere presence in this site increases mortality fourfold by mechanisms that remain unknown. many patients who survive the initial surgical trauma still succumb to multi-organ failure and septicemia secondary to an invasive nosocomial infection. the sequelae of shock, hypoxia, and parental nutrition result in injury to the intestinal mucosa, changes in gut permeability, and failure of intestinal defense mechanisms. these conditions put patients at risk for infection and multiple organ failure secondary to the translocation of enteric bacteria, initiating a systemic release of inflammatory mediators-a process that has been termed gut-derived sepsis. intestinal p. aeruginosa senses host factors released during stress and responds by activating its virulence gene machinery. as such, the presence of a highly activating intestinal milieu serves to induce virulence in strains of p. aeruginosa and this correlates to the severity of a patient's illness. while the host-pathogen interaction is a dynamic process, the study expects that as a patient's illness worsens or resolves over time, the "virulence-activating" properties of their intestinal milieu will change accordingly. this study will conduct a prospective observational trial in a population of critically ill patients at the universtiy of chicago medical center. this trial will entail collecting and screening stool samples obtained from critically ill patients for their virulence inducing capabilities on laboratory strains of p. aeruginosa using in vitro and in vivo assays. the study also plans to isolate strains of intestinal p. aeruginosa from stool samples to determine the prevalence of intestinal p. aeruginosa in a population of critically ill patients.


Eligibility criteria:
inclusion criteria: * any ethnicity * age \> 18 years and \< 85 years exclusion criteria: * a known history of hiv/aids * active pregnancy * are incarcerated will be excluded from the study.
heating precondition of epidural catheter decrease the incidence of injury to blood vessel during epidural catheter placement

Conditions: Epidural Anesthesia

Summary: to explore the effect of heating precondition of epidural catheter on the incidence of injury to blood vessel during epidural catheter placement.


Eligibility criteria:
inclusion criteria: * elective cesarean delivery * epidural anesthesia. exclusion criteria: * blood coagulation disorders
a dose conversion study of epoetin alfa in subjects with the anemia of chronic kidney disease.

Conditions: Anemia; Chronic Renal Insufficiency

Summary: the purpose of this study was to evaluate hemoglobin stability in subjects who had received darbepoetin alfa for a minimum of 3 months prior to study entry who were then converted to epoetin alfa at the same dosing frequency to maintain a hemoglobin level of 12 plus or minus 1 g/dl (range 11-13- g/dl).

this was a prospective, multicenter study in subjects with chronic kidney disease. the study was designed to address hemoglobin stability after drug conversion to epoetin alfa in subjects previously receiving darbepoetin alfa therapy. the study was to enroll approximately 180 subjects with chronic kidney disease. eligible subjects were those with chronic kidney disease who were receiving darbepoetin alfa every two, three, or four weeks for a period of 3 months or more and who had a stable hemoglobin (hb) level at study entry of 12 g/dl (plus or minus 1 g/dl (11-13 g/dl). subjects receiving darbepoetin alfa every 2, 3 or 4 weeks were switched over to epoetin alfa which they received at the same dosing frequency ( every 2, 3 or 4 weeks) upon study entry and throughout the 24 week study period. clinical safety was assessed for the occurrence and severity of adverse events. blood tests (complete blood count, platelets, reticulocyte count, iron, were assessed at pre-determined intervals throughout the study. vital signs (e.g. blood pressure) were checked at each visit. subjects received epoetin alfa at the same dosing frequency that they had previously received darbepoetin alfa. subjects received 20,000 units (u) epoetin alfa subcutaneously (sc) every two weeks; 30,000 u epoetin alfa sc every 3 weeks; or 40,000 u epoetin alfa sc every 4 weeks.

Eligibility criteria:
inclusion criteria: * subjects with chronic kidney disease defined as serum creatinine of 1.5 to 6.0 mg/dl for women and 2.0 to 6.0 mg/dl for men * glomerular filtration rate (gfr) within 15-60 ml/min * subjects on darbepoetin alfa for 3 months or more and with a stable entry hemoglobin level of 12 (plus or minus 1 g/dl * range 11-13 g/dl) * subjects receiving darbepoetin alfa on an every two, three, or four week dosing schedule * female subjects with a reproductive potential must have a negative ruine pregnancy test within 7days of the first dose of study drug. exclusion criteria: * no uncontrolled high blood pressure as assessed by the primary physician * no known hypersensitivity to mammalian cell-derived products * no known hypersensitivity to human albumin * not receiving dialysis or scheduled to receive dialysis during the course of the study * no severe congestive heart failure (new york heart association class iv) * no known severe stable or unstable coronary artery disease.

Keywords: anemia low blood count chronic kidney disease chronic kidney failure darbepoetin alfa epoetin alfa recombinant human erythropoietin
role of lung ultrasonography in diagnosing atelectasis in robotic pelvic surgeries

Conditions: Atelectasis

Summary: general anaesthesia results in developement of atelectasis in dependent areas of the lungs exposing patients to an increased risk of hypoxaemia.during pelvic robotic surgeries pneumoperitoneum and steep trendelenburg position further increases atelectasis. lung ultrasound imaging is a promising , noninvasive , non-radiant, portable tool to study intraoperative lung atelectasis.

methodology -in the operation room 5 lead electrocardiogram (ecg) , pulse oximetry (spo2 ) , noninvasive blood pressure (nibp), end tidal carbon di oxide (etco2 )and core temperature will be monitored , intravenous assess will be established with large bore cannula ,under local anesthesia radial artery cannulation will be performed , standard general anesthesia with oral cuffed endotracheal tube and intermittent positive pressure ventilation (ippv ) will be provided to all patients.anaesthesia will be induced with fentanyl 1-2 mcg/kg-1 , morphine 0.5mg/kg-1 ,propofol sleeping dose , atracurium 0.5mg/kg-1,and maintained with air/o2 sevoflurane , propofol infusion @100- 150 mcg/kg-1 to maintain bispectral index (bis) between 40 -60 and atracurium infusion to maintain train -of - four (tof ratio) \< 0.5 baseline lung ultrasound imaging will be performed to record 4 point lung aeration score ( 0= normal lung /no aeration loss , 1= mild aeration loss, 2=moderate aeration loss ,3=severe aeration loss ) at t1 - 5 minutes after induction of anaesthesia and before docking robotic instruments in 6 basal zones in both lungs ( 3 zones in each lung ) and labelled as zone i (right anterior basal ) zone ii ( right lateral basal) and zone iii (right posterior basal) . zone iv ( left anterior basal) , zone v (left lateral basal ) , zone vi ( left posterior basal ).t2 - lung ultrasound imaging will be performed to record aeration score after removal of robotic arms at the end of robotic surgery and before extubation in 6 basal zones in both lungs.ti arterial blood gas 5 minutes after induction of anesthesia and before docking robotic instruments.tii -arterial blood gas 5 minutes after the end of robotic surgery and de docking robotic instruments.all patients will receive positive end expiratory pressure (peep) 5 cms of water (h2o) intraoperatively . intraabdominal pressure will be maintained at 15 cms h2o. any decrease in oxygen saturation \< 96 % and intervention required will be noted. at the end of surgery , neuromuscular blockade will be reversed , trachea extubated and patient shifted to postanaesthesia care unit.

Eligibility criteria:
inclusion criteria: \* patients undergoing robotic pelvic surgeries under general anaesthesia exclusion criteria: * lung consolidation * lung fibrosis * cardiac failure * previous thoracic surgery * bmi \> 32

Keywords: lung ultrasonography step trendelenburg position
the microbiological assessment of deep carious lesions after step-wise excavation and diode laser cavity disinfection .

Conditions: Antibacterial Effect of Diode Laser

Summary: this study will be conducted to assess antibacterial effect of the diode laser in deep carious cavity after step wise excavation using the bacteriological assessment method.

each patient should have at least two deep carious lesions the first clinical step in all teeth will be the opening of the cavity and the removal of undermined enamel . caries at the lateral walls of the cavity and at the enamel-dentin junction was completely removed with excavators and/or round carbide burs at low speed. subsequently, the central cariogenic biomasses and superficial part of the necrotic and demineralized dentin were removed. then excavation continued until the pulp exposure would occur with further excavation; thus, a layer of soft carious dentin was left on the cavity floor adjacent to the pulp wall. a dentine samples will be then collected from the base of the cavity using sterile spoon excavator from the both groups for baseline bacteriological assessment and another sample will be taken after disinfection with diode laser in the intervention group . in the two groups the remaining innermost layer of carious dentin are covered with calcium hydroxide the cavity was then sealed with restorative material (resin modified glass ionomer) after a 6 month period. this time was considered adequate for calcium hydroxide to exert its effect and for the pulp to respond with possible formation of tertiary dentin. the teeth were followed up every month and the integrity of the temporary restoration checked. after this interval of 6 months. after the rubber dam application, the temporary filling is removed samples are collected and the teeth are finally restored

Eligibility criteria:
inclusion criteria: 1. patients with at least two deep occlusal carious lesion . 2. 18 - 25years. 3. males or females. 4. good oral hygiene. 5. co-operative patients approving the trial and willing to sign a written consent. exclusion criteria: 1. pregnancy. 2. systemic disease or severe medical complications. 3. heavy smoking. 4. xerostomia. 5. lack of compliance. 6. evidence of temporomandibular joint disorders.
early childhood follow-up of congenital diaphragmatic hernia survivors

Conditions: Hernia, Diaphragmatic

Summary: the primary objective of this study is to determine the medical and neurodevelopmental outcomes of congenital diaphragmatic hernia (cdh) survivors at school-age (4-6 years) follow-up. it is generally assumed that older cdh survivors have normal daily function and are able to live normal lives, but this has not been adequately studied.

congenital diaphragmatic hernia (cdh) is a relatively rare malformation, seen in approximately 1 in 3000-5000 live births. the overall survival for infants born with cdh ranges from 50-70% despite continuing advances in prenatal diagnosis and post-natal medical and surgical care. infants with cdh remain one of the most complex groups of patients to care for - both in the intensive care nursery and after hospital discharge. several studies have shown that cdh survivors have predictable pulmonary, gastrointestinal, cardiac, and neurologic morbidities. in particular, cdh survivors are at an increased risk for growth and nutrition difficulties, including feeding problems, symptomatic gastroesophageal reflux, and failure to thrive. they are also more likely to suffer from chronic lung disease, bronchial hyperreactivity, and pulmonary hypertension. in addition, a significant number of cdh survivors show evidence of neurocognitive delay, hearing impairment, and behavioral disorders in follow-up studies. most outcome studies of cdh survivors have focused on the 18-36 month follow-up period. however, there is a paucity of literature on longer-term, school-age outcomes of these children. in order that we might better understand the impact of our current cdh management protocols, it is imperative to determine whether the cognitive delays and other morbidities noted in these patients at an early age are of a transient nature, or persist throughout childhood. it is also crucial to develop a predictive model to understand which patients with cdh will undoubtedly develop long-term neurodevelopmental impairment. collecting and sharing knowledge with the broader community of neonatal intensive care providers who manage infants with cdh will ultimately help guide therapeutic strategies in the intensive care nursery so that parents can make informed decisions about aggressiveness of care and we may optimize the outcomes of this unique patient population.

Eligibility criteria:
inclusion criteria: * survivors of cdh who are at least 4 years old at the time of the study will be eligible for inclusion in the follow-up portion of the study. exclusion criteria: * spanish-speaking only children and families.

Keywords: hernia, diaphragmatic asthma feeding and eating disorders of childhood growth & development
innovative strategy to offer online test and treat for thai msm/tg

Conditions: HIV/AIDS

Summary: this study will ask thai msm and transgender women (tg) participants to self-select to participate in one of the 3 different study groups which provide various degrees of integrated online interventions and offline interventions for the recruit-test-treat-retain for hiv prevention and care among 3 groups (a, b1 and b2). all participants will be followed up either offline or online for 12 months. hiv-negative participants will be scheduled for repeat htc at months 6 and 12. hiv-positive participants will be scheduled either offline or online to review their treatment history at months 6 and 12. hiv-negative participants in group b1 and b2 can choose again at months 6 and 12 to switch from the online to offline, and vice versa, at the hiv testing/post-test counseling step and the referral to hiv treatment step


Eligibility criteria:
inclusion criteria: 1. thai national 2. age \>18 years 3. men or transgender women who have at least 1 unprotected anal sex with men within the past 6 months 4. live in the bangkok metropolitan region (bangkok, pathumthani, samutprakarn, samutsakorn, nakornpathom and nonthaburi) or pattaya 5. not known to be hiv-positive, i.e., never tested for hiv or previous hiv test(s) negative 6. willing to participate in the study for 12 months. 7. provide verbal informed consent exclusion criteria: 1. known hiv-positive serostatus

Keywords: hiv home testing
bioequivalency study of levetiracetam 750 mg tablets under fasting conditions

Conditions: Seizures

Summary: the objective of this study was to prove the bioequivalence of levetiracetam 750 mg tablets under fasted conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. treatment with known enzyme altering drugs. history of allergic or adverse response to levetiracetam or any comparable or similar product.
prognosis of cirrhotic patients admitted to the general intensive care unit between 2014 and 2024: a regional retrospective multicentre cohort study

Conditions: Cirrhosis; Intensive Care Medicine; Acute on Chronic Liver Failure(ACLF)

Summary: ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. this study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients. the following hypotheses will be tested: * improvement in intensive care and overall prognosis compared with data from the literature prior to 2014 * improved access to liver transplantation compared with the literature prior to 2014 * improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.). * centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to th.


Eligibility criteria:
inclusion criteria: patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between january 2014 and december 2024. exclusion criteria: none

Keywords: prognosis cirrhosis icu aclf