Kornimate/medical-research-clean huggingface dataset:
effect of preclinical training in periodontal instrumentation on undergraduate students&#39; anxiety, clinical performance and satisfaction

Conditions: Preclinical Education; Typodont-phantom Head; Anxiety

Summary: the purpose of this study was to evaluate the effect of periodontal instrumentation preclinical training using a teaching typodont-phantom head model on undergraduate students; anxiety levels, clinical performance, and educational satisfaction.

sixty fourth-year undergraduate dental students will be randomly divided into two groups. both groups will receive one hour of theoretical periodontal training. group 1 will receive only theoretical training, while group 2 will complete this training as well as pre-clinical practical training with a typodont-phantom head with synthetic calculus. before performing supragingival instrumentation on their first patient, students in both groups will be administered a state anxiety test. after the procedures, participants will complete a visual analog scale (vas) to assess training satisfaction. students\&#39; clinical performance will be evaluated using the scaling procedure score sheet.

Eligibility criteria:
inclusion criteria: * to be a fourth year student of the faculty of dentistry * to successfully complete pre-clinical theoretical and practical training * to perform periodontal treatment for the first time in the undergraduate clinic exclusion criteria: * not being a fourth year student of the faculty of dentistry * lack of attendance to pre-clinical theoretical training * failure to demonstrate competence in pre-clinical theoretical education * having previously performed periodontal treatment in undergraduate clinic

Keywords: preclinical education typodont-phantom head anxiety
efficacy of sasi bypass for type-2 diabetic obese patients

Conditions: Diabetes Mellitus Type 2 in Obese

Summary: the investigator modified the sanator's operation by performing a loop rather than roux-en-y bipartition reconstruction and the investigator are reporting the first clinical results of the outcomes of sasi bypass as a mode of functional restrictive and neuroendocrine modulation therapeutic option for obese type 2 diabetes mellituspatients.

all patients were subjected to thorough history, clinical examination and laboratory investigations including basic preoperative investigations, lipid profile, thyroid and suprarenal hormonal evaluation. in addition, patients may undergo further assessment for pulmonary functions or gastroesophageal disease including endoscope. . abdominal ultrasound was done to exclude calcular cholecystitis and to evaluate the degree of fatty liver. reduction the size of fatty liver was done by putting all patients on low-calorie protein diet for 6 weeks. deep vein thrombosis prophylaxis started 12 h before surgery with low molecular weight heparin subcutaneous injections . preoperative data included age, gender, initial weight, initial body mass index (bmi), obesity comorbidities and treatment medications used (chest problems, diabetes, arterial hypertension and cardiac ischaemia, hyperlipidemia, obstructive sleep apnea syndrome, gall stones, urinary stress incontinence, joint pain, depression, infertility and heart burn). postoperative data included hospital stay, early postoperative complications during the first month (e.g. fever, collection, bleeding, vomiting, leak and port site problems .long-term complications more than 1 month after surgery (e.g. nausea, vomiting, reflux, stricture, intestinal obstruction , hypoalbuminemia , anemia and calcium or iron or vitamin d , vitamin b12 deficiency and), excess weight loss and bmi were collected.

Eligibility criteria:
inclusion criteria:type 2 diabetic obese pateints - exclusion criteria:patients age above 65 or below 18 years old, history of upper laparotomy, unfit for anesthesia or laparoscopy, major psychological instability and drug abuse. -

Keywords: type 2 diabetes , obesity , sasi
effect of intensive language therapy in subacute stroke patients

Conditions: Stroke; Rehabilitation; Language

Summary: early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications. however, there was no consensus of proper amount of language rehabilitation in stroke patients. in this study, the investigators investigated the effects of the intensive language rehabilitation during subacute phase to improve language function in patients with first-ever strokes.

intensive language rehabilitation group - language rehabilitation therapy by language therapist for 1 hours on every working day for 4 weeks conventional language rehabilitation group - language rehabilitation therapy by language therapist for 30 minutes on every working day for 4 weeks

Eligibility criteria:
inclusion criteria: * acute first-ever stroke * left hemispheric stroke * korean version of frenchay aphasia screening test(k-fast) \< 25 (less than 65 years old), k-fast \<20 (65 years old and more than 65 years old) at 7 days after stroke onset * right handedness exclusion criteria: * transient ischemic stroke
effectivenes of erector spinae plane block in percutaneous nephrolithotomy?

Conditions: Postoperative Pain; Nephrolithotomy, Percutaneous; Erector Spinae Plane Block

Summary: this study investigates the effectiveness of the erector spinae plane block (espb) in pain management of patients undergoing pnl.

although percutaneous nephrolithotomy(pnl) is a minimally invasive procedure, it causes severe postoperative pain due to dilatation of the renal capsule and parenchymal duct and peritubal distension of the nephrostomy tube. pnl-related pain has a limited response to oral and intravenous treatments. the primary aim of our study is to investigate the effectiveness of the erector spinae plane block (espb) in pain management of patients undergoing pnl. our secondary aim is determining if any possible clinical effect of espb in terms of serial peak expiratory flow measurements, postoperative agitation score of the patient (riker score), ambulation time, length of hospital stay.

Eligibility criteria:
inclusion criteria: * patients undergoing pnl between 18-65 years old exclusion criteria: * serious cardiac, respiratory, hepatic, renal or haemotologic disease * mental disorder and hearing problem * anxiety, depression and / or other psychiatric disorders * pregnancy * refusal of patient * allergy or contraindications to drugs used in the study * asa \> 2 inflammation or infection over injection site obese patients bmi ≥35/
measurement of endotracheal tube cuff pressure in emergency department patients

Conditions: Intubation, Intratracheal

Summary: the purpose of this research is to measure the endotracheal tube cuff pressure in patients who have been endotracheally intubated emergently in the emergency department or in the field by prehospital personnel. overinflation of ettc pressure is associated with injury, and we seek to determine if the phenomenon of excessively inflated ettc can be detected in endotracheally intubated patients in the ed. there is no experimental aspect to this study, it is only descriptive. measurement of ettc pressure is already performed by respiratory therapy/respiratory care. we simply seek to assess these measurements to determine if any patients in fact have high ettc pressure. if it is found that patients do have ettc with high pressures, this might allow emergency department staff or prehospital personnel such as paramedics or emts to use this information to seek methods by which endotracheal intubation can be improved and patients can be intubated without excessive ettc pressure. this is a pilot study. we have conducted several in vitro studies, which have all demonstrated that paramedics, emts, and emergency department physicians practice endotracheal intubation in a method that might result in excessively inflated ettc.


Eligibility criteria:
inclusion criteria: * patient emergently endotracheally intubated with a cuffed endotracheal tube. exclusion criteria: * endotracheal intubation procedure performed in a setting other than the prehospital (field) or emergency department of participating institution. this specifically excludes endotracheally intubated patients transferred from another hospital, chronic care facility, or other location. * non-emergent or elective endotracheal intubation.

Keywords: endotracheal intubation tracheal pressure cufflator
this study observes the use of new oral anticoagulants (noacs) in patients with a heart rhythm disorder in spain

Conditions: Atrial Fibrillation

Summary: the primary objective of the study is to describe the usage of noacs in patients with nvaf, in the hospital setting, based on the baseline characteristics at the time of first noac initiation.


Eligibility criteria:
inclusion criteria: * the patient is willing and provides written informed consent to participate in this study * the patient is at least 18 years of age * the patient has a diagnosis of non-valvular atrial fibrillation (nvaf) * the patient is on treatment with noac according to its approved local smpc and has initiated his first noac starting from november 2016 exclusion criteria: -if the current participating patient participate in any clinical trial of a drug or device will be excluded
pain relief satisfaction with new educational materials

Conditions: Patient Satisfaction

Summary: this study compares patient satisfaction after labor and delivery with access to either the default educational materials available, or to a table computer set to display an educational website, thepainlesspush.com.

this is a prospective randomized controlled study. the investigators hypothesize that parturients with access to the website will exhibit greater satisfaction with labor and delivery pain control. potential participants will be recruited from the university of new mexico hospital (unmh) labor \& delivery floor. patients will be enrolled following an oral consent process. they will be randomized into either control group or intervention group. control group participants will have their standard of care visit with an anesthesiologist and routine hospital pain-relief information. intervention group participants will have their standard of care visit with an anesthesiologist, plus one hour in which to view the patient education website thepainlesspush.com, on an ipad provided by the anesthesiology department for this purpose. after their delivery and transfer to the mother/baby unit, participants will complete a satisfaction survey brought to them by a study team member. participants will complete the survey following their delivery and prior to discharge. the primary team will notify us with expected discharge in which we will retrieve the survey from them in their room and answer any last questions. their active participation in the study will be complete at this time. after a participant completes the satisfaction survey, research team members will collect demographic information and relevant obstetric/medical history information from the electronic medical record.

Eligibility criteria:
inclusion criteria: * all english- or spanish-speaking patients who are admitted to unmh labor and delivery for planned progression to active labor. exclusion criteria: * age under 18 years * patients unable to provide consent for medical procedures * patients who do not speak either english or spanish
phase ii clinical study to compare the efficacy and safety of hlx07 + serplulimab +chemotherapy versus placebo + serplulimab + chemotherapy in first-line treatment of patients with recurrent or metastatic npc

Conditions: Nasopharyngeal Carcinoma by AJCC V8 Stage

Summary: a randomized, double-blind, multi-center phase ii clinical study to compare the efficacy and safety of hlx07 (recombinant anti-egfr humanized monoclonal antibody injection) + serplulimab (hlx10, recombinant anti-pd-1 humanized monoclonal antibody) +chemotherapy versus placebo + serplulimab + chemotherapy in first-line treatment of patients with recurrent or metastatic nasopharyngeal carcinoma (npc)


Eligibility criteria:
inclusion criteria: 1. voluntarily participate in the clinical study; fully understand, be informed about the study, and have signed the informed consent form (icf); be willing to follow and be able to complete all trial procedures. 2. males or females aged ≥ 18 years at the time of signing the icf. 3. histologically or cytologically proven recurrent or metastastic npc. 4. at least one measurable target lesion is assessed by the irrc according to the recist v1.1 within 4 weeks prior to randomization. 5. an ecog performance status score of 0-1 within 7 days prior to the first dose of the investigational product. 6. an expected survival period ≥ 12 weeks. exclusion criteria: 1. other active malignancies within 3 years prior to the first dose of investigational product. localized tumors that have been cured such as superficial bladder carcinoma, prostate carcinoma in situ, cervical carcinoma in situ, and breast cancer in situ are acceptable. 2. patients who are going to receive or have received an organ or bone marrow transplant. 3. with uncontrolled pleural effusion, pericardial effusion, or ascites requiring frequent drainage (monthly or more frequently). 4. with cerebrovascular accident, myocardial infarction, unstable angina, poorly controlled arrhythmia (including qtc intervals ≥ 450 ms for males and ≥ 470 ms for females) (qtc intervals are calculated by fridericia formula) within half a year. 5. class iii to iv cardiac insufficiency according to new york heart association (nyha) classification (appendix 5) or an lvef (left ventricular ejection fraction) \< 50% by cardiac color doppler. 6. inadequately controlled hypertension (systolic blood pressure ≥ 150 mmhg and/or diastolic blood pressure ≥ 100 mmhg). 7. with human immunodeficiency virus (hiv) infection.
self-perceived in medical students undergoing distance learning

Conditions: Educational Problems; Medical Students; COVID-19 Pandemic

Summary: our primary objective is identifying the degree of self-perceived competence in medical students without clinical rotations during the covid-19 pandemic to know how prepared the students could be when they are professionals because they lack clinical skills in front of an actual patient and can be affected to be accepted in hospitals because they will have to acquire a phase of training later. without a clinical rotation, one can be deprived of the essential educational value.the study design is an observational cross-section study in which an anonymous survey will be shared online on google forms platform. students will be asked for their participation; after obtaining verbal and consent, the survey will be distributed using social media groups such as foundation school groups. for this study, the spanish version of the self-perceived competence scale will be used (ref). this scale is comprised of 21 questions divided into five factors that assess: 1) demonstration of the essential clinical skills, 2) demonstration of clinical reasoning, decision making, and problem-solving skills, 3) management of life-threatening medical conditions, 4) management of common medical problems and 5) placing patients' needs and safety at the center of the care process. each item has a likert scale answers of 4 options ranging from "incompetent (1)", "somewhat incompetent (2)", "somewhat.


Eligibility criteria:
inclusion criteria: * medical students currently attending college in a distance learning modality. * \> 18 years exclusion criteria: * medical professionals and specialists * university students * \< 18 years * medical students currently attending clinical rotations
bio-equivalence study with clinical endpoints in the treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: this study is to evaluate the therapeutic equivalence and safety of taro product to rld in the treatment of acne vulgaris.

the study objectives are to evaluate the therapeutic equivalence and safety of taro product to rld in the treatment of acne vulgaris and to demonstrate the superiority of the efficacy of the test and reference products over the placebo control.

Eligibility criteria:
inclusion criteria: * healthy male or non-pregnant female aged ≥ 12 and ≤ 40 years with a clinical diagnosis of acne vulgaris * subjects who are 18 years of age or older (up to the age of 40) must have provided irb approved written informed consent. subjects 12 to 17 years of age, inclusive, must have provided irb approved written assent; this written assent must be accompanied by an irb approved written informed consent from the subject's legally acceptable representative (i.e., parent or guardian). * subjects must have a definite clinical diagnosis of acne vulgaris severity grade 2, 3, or 4 as per the investigator's global assessment (iga). exclusion criteria: * female subjects who are pregnant, nursing or planning to become pregnant during study participation. * subjects with a known hypersensitivity to clindamycin or lincomycin and/or any ingredients in the study drugs. * subjects with the presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris (e.g., on the face: rosacea, dermatitis, psoriasis, squamous cell carcinoma, eczema, acneiform eruptions caused by medications, steroid acne, steroid folliculitis, or bacterial folliculitis).
functional massage of teres major muscle

Conditions: Subacromial Impingement Syndrome; Trigger Points

Summary: purpose: subacromial impingement syndrome is the most common shoulder condition. myofascial trigger points in teres major muscle can be associated with this syndrome. the investigators objective is to find out if adding manual therapy specifically for teres major trigger points can produce better results in these patients. method: a randomized controlled pilot study was carried out. fifty people were randomly assigned to one of two groups: intervention group or control group. both groups received a protocolized physical therapy treatment while the intervention group additionally received manual therapy for teres major trigger points.


Eligibility criteria:
inclusion criteria: * age 18 years and over * clinical diagnosis of subacromial impingement syndrome. * detectable trigger points in teres major muscle. * sign informed consent form. exclusion criteria: * presence of wounds or cutaneous alterations in the shoulder region * previous surgery in the shoulder * presence of acute inflammatory process in the shoulder (\< 7 days), * being involved in litigation or compensation processes * not having a domain of the language that could make the informed consent not understandable.
electrical vestibular stimulation (vens): assessment of ampk & sirt1 following repeated usage

Conditions: Overweight and Obesity

Summary: the vestibular system which is responsible for balance and equilibrium constitutes our sixth sense. metabolic syndrome is a constellation of metabolic abnormalities characterized by obesity, insulin resistance (diabetes mellitus), hypertension, and dyslipidemia. it is generally agreed that a combination of three or more of the following components must be present: large waist circumference, elevated triglyceride, decreased high-density lipoprotein (hdl) cholesterol raised blood pressure, and elevated fasting blood sugar (fbs). sirtuin 1 (sirt1) is one of seven mammalian orthologs of the yeast protein silent information regulator. it is a conserved nad-dependent protein deacetylase that decreases in cells that have high insulin resistance. in vivo, insulin resistance and metabolic syndrome were associated with low sirt1 gene and protein expression. sirt1 plays an important role to stimulate ampk in improving mitochondrial function both in-vitro and in-vivo. adenosine 5'-monophosphate (amp)-activated protein kinase (ampk) is a key factor in regulating energy metabolism, placing it at the center stage in studies of diabetes and related metabolic disorders like metabolic syndrome. it was reported that over a period of 6 weeks regular vestibular rehabilitation exercises caused an increase in the expression of sirt1. the sleep inducing effects of vestibular stimulation is well known. earlier studies reported improvement in the scores of pittsburgh sleep quality index (psqi) and epworth sleepiness scale (ess) followed by the vestibular stimulation. hence, we hypothesize that vestibular stimulation will lead to up-regulation of both sirt1 and ampk.


Eligibility criteria:
inclusion criteria: male and female participants 35-60 years of age group metabolic syndrome (bmi 25-35 kg/m2) type 2 diabetes hyperlipidemia willing participants exclusion criteria: using beta blockers ear problems ( assessed during physical examination) under any kind of therapy or treatment with severe complications vestibular disorders
topical corticosteroids on the incidence of postinflammatory hyperpigmentation after qsndyag laser

Conditions: Lentigines; Post Inflammatory Hyperpigmentation

Summary: to investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.

* the incidence of post inflammatory hyperpigmentation (pih) after treating lentigines with q-switched nd:yag laser was 78.3%. * it has been found that the incidence of pih decreased to 40% after applied topical high potency steroid 2 days after the laser treatment. * by these anti-inflammatory and anti-pih effects of the high potency steroid, the investigators aimed that the application of steroid 2 days before and 2 days after the laser treatment would be better reduction in the incidence of pih after q-switched nd:yag laser.

Eligibility criteria:
inclusion criteria: * having multiple lentigines on both sides of the face * fitzpatrick skin phototype 3-5 exclusion criteria: * patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind * patients who have photosensitive dermatoses * pregnancy and lactation woman * patients with wound infections (herpes, other) on the day of treatment * patients with moderate and severe inflammatory acne, immunosuppressed patients, history of vitiligo * patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care

Keywords: post inflammatory hyperpigmentation topical high potency steroid qs ndyag laser
lung surgery with enhanced recovery vs. lung surgery without enhanced recovery

Conditions: Lung Cancer; Surgery; ERAS

Summary: objective: the adoption of enhanced recovery surgery programs in lung resection is relatively recent with limited outcome data. this study aimed to determine the impact of an enhanced recovery surgery pathway on short- term and long- term results in patients undergoing lung resection for primary lung cancer. methods: a randomized controlled trial was designed to collect the perioperative data on consecutive patients undergoing lung resection for primary lung cancer. patients will be randomizely assigned to the eras- group and control- group. short-term and long- term effect will be compared between the two groups.


Eligibility criteria:
inclusion criteria: patients with stage i-iiia non-small-cell lung cancer underwent radical resection or other benign lung lesions need vats surgery. - exclusion criteria: cardio-pulmonary function couldn't tolerate surgery -