Kornimate/medical-research-clean huggingface dataset:
parasitic ulcer treatment trial pilot

Conditions: Acanthamoeba Keratitis

Summary: this is a study of optimal treatments for acanthamoeba keratitis. in the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine. after four weeks of therapy, participants will be re-randomized to early corticosteroids, later corticosteroids, or placebo.

acanthamoeba keratitis is a rare eye infection that is difficult to treat. the mainstay of therapy is a biguanide agent such as chlorhexidine, though recent studies have found povidone iodine to be effective for killing acanthamoeba organisms in vitro. thus, we randomize participants to topical chlorhexidine 0.04% monotherapy (i.e., routine care) versus topical chlorhexidine 0.04% plus topical poviodine iodine 2.5%. the primary outcome is clearance of acanthamoeba from the ocular surface at 4 weeks. the role of topical corticosteroids in acanthamoeba keratitis is controversial. topical corticosteroids can promote growth of acanthamoeba, but may also reduce inflammation and vision-threatening complications of infection. here, we randomize participants who have completed a course of anti-amoebic therapy to one of three groups: early prednisolone sodium phosphate 1% (started at 4 weeks), late prednisolone sodium phosphate 1% (started at 6 weeks) or placebo (started at 4 weeks). the primary outcome will be visual acuity at 6 months.

Eligibility criteria:
trial 1 inclusion criteria: * smear or culture positive for acanthamoeba * age 13 years or greater trial 1 exclusion criteria: * interstitial or viral keratitis on history or examination * corneal perforation * therapeutic keratoplasty for acanthamoeba keratitis * unwillingness or inability to follow-up (e.g., living too far from hospital) trial 2 inclusion criteria * smear or culture positive for acanthamoeba, with 4 weeks of anti-amoebic treatment * age 13 years or greater * willing to participate in study trial 2 exclusion criteria * interstitial or viral keratitis on history or examination * fungus identified on culture and smear after 2 weeks of anti-amoebic treatment * corneal perforation * therapeutic keratoplasty for acanthamoeba keratitis * unwillingness or inability to follow-up (e.g., living too far from hospital)
study on the combination regimen of dexamethasone ifosfamide cisplatin etoposide in patients with nk/t cell lymphoma

Conditions: Lymphoma

Summary: the purpose of this study is to evaluate the efficacy and tolerability of the combination chemotherapy of dice in the patients with nk/t cell lymphoma.

patients with nk/t cell lymphoma usually have a bad prognosis. these patients cannot be treated successfully with the conventional chemotherapy of chop.the investigators did this trial to evaluate the efficacy and tolerability of the combination chemotherapy of dice in the patients with nk/t cell lymphoma.

Eligibility criteria:
inclusion criteria: * age range 18-75 years old * histological confirmed nk/t cell lymphoma * ecog performance status less than 2 * life expectancy of more than 3 months * none of major drugs in the trial (ifo,vp16,ddp) has been previously used * normal laboratory values: hemoglobin \> 80 g/dl, neutrophil \> 2×109/l, platelet \> 100×109/l, serum creatine \< 1.5×upper limitation of normal (uln), serum bilirubin \< 1.5×uln, alt and ast \< 2.5×uln exclusion criteria: * pregnant or lactating women * serious uncontrolled diseases and intercurrent infection * the evidence of cns metastasis * history of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix

Keywords: nk/t cell lymphoma response rate ttp os toxicities
radial artery stenosis following picco catheter implementation

Conditions: Artery Stenosis

Summary: cardiac output monitoring devices are commonly used in icu patients. the most precise use direct measurement, which require artery cannulation. the gold standard is swan-ganz catheter, but it is a very invasive technique. picco (pulse index continuous cardiac output) is the alternative way of haemodynamic monitoring. this technology is the easy, less invasive and cost-efficient tool for determining the main hemodynamic parameters of critically ill patients. it is based on two physical principles - transpulmonary thermodilution and pulse contour analysis. both principles allow the calculation of haemodynamic parameters in critically ill patients. picco method requires peripheral artery cannulation. cannulation may be followed by artery stenosis. aims of the study are: 1. to verify the occurrence of radial artery stenosis after 3 days of having a picco cannula in place. 2. whether 5 days cannulation of radial artery with picco catheter is related to more frequent stenosis rate. an additional assessment: 1. to check whether the eventual stenosis is still present after 3, 14 and 30 days after decannulation - assessment depending on patients availability

barbeau test and doppler - ultrasonography preceded radial artery cannulation. catheter removal (after 3 or 5 days of cannulation) is followed by doppler - usg. usg -doppler is performed also 3, 14 and 30 days after decannulation - depending on patient being available

Eligibility criteria:
inclusion criteria: * critically ill patients with haemodynamic monitoring required exclusion criteria: * barbeau test type d in radial artery * artery inaccessible for cannulation - based on doppler ultrasonography

Keywords: artery cannulation haemodynamic monitoring
follicular activation by fragmentation of ovarian tissue

Conditions: Diminished Ovarian Reserve

Summary: the primary objective of this study is to assess the chances of increasing the number of antral follicles in ovarian tissue of patients with diminished ovarian reserve by activation of primordial follicles through ovarian cortex fragmentation. secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after ivf.


Eligibility criteria:
inclusion criteria: 1. previous ≥ 2 poor ovarian responds (≤ 3 retrieved oocytes) in an antagonist cycle with a minimum of 225 iu gonadotropins a day or corifollitropin 150 mcg) in patients \>35 i \<40 years 2. previous cycle with ≤ 3 retrieved oocytes) in an antagonist cycle with a minimum of 225 iu gonadotropins a day or corifollitropin 150 mcg) in patients \>35 i \<40 years with antral follicle count (afc) ≤ 5 i/ili antim¸ulelrian hormone (amh) ≤ 6.5pmol/l 3. premature ovarian insufficiency according to european society of human reproduction and embryology (eshre) development group, 2015 in patients 18-40 years 4. undetectable amh serum levels and follitropin (fsh) \>35 iu/ml in two serum samples separated by at least 4 weeks exclusion criteria: 1. clinical/ultrasonographical signs of endometriosis 2. previous ovarian/pelvic surgery 3. previous gonadotoxic treatment 4. genito-urinary tract malformations 5. extreme male infertility ( \<10 000 progressively motile sperms in the semen sample) 6. inform consent unsigned -

Keywords: premature ovarian failure infertility, female ovarian tissue fragmentation
effects of fascial plan blocks on pulmonary functions

Conditions: Pain, Postoperative; Respiratory Function Loss

Summary: in addition to the traumatic effect of the operation, the effort to immobilize the auxiliary respiratory muscles due to pain causes a decrease in postoperative respiratory function (especially in thoracic and upper abdominal surgeries). in addition, superficial and tachypneic breathing caused by the inability of the patient to take deep breaths with pain leads to closure of small airways and increase in intrapulmonary shunts, resulting in hypoxia. postoperative pain management is important not only to prevent pain but also to reduce pulmonary complications that may occur due to changes in lung function and to reduce mortality and morbidity by controlling the stress response. pain after nausea and vomiting is the most common reason for hospitalization after laparoscopic surgery. although pain in laparoscopic cholecystectomy (lc) has many components including incisional, visceral and reflected, the primary source of pain is incisional pain. a multimodal analgesic approach (nsaii, paracetamol, opioids, local infiltration, facial plane blocks and paravertebral and periparavertebral blocks) is recommended. regional anesthesia combined with general anesthesia reduces the stress response associated with surgery and reduces the need for opioid use. subcostal tap block; injection of local anesthetic between the internal oblique and transversus abdominis muscles in the upper quadrant of the anterior abdominal wall blocks the anterior cutaneous branches of the thoracoabdominal nerves. external oblique fascial plane block (eoib); blocks both the anterior and lateral cutaneous branches of the thoracoabdominal nerves. it is performed between the 6th-7th costae. there is a cutaneous sensory block between t6-t9 in the midabdomen and t6-t10 in the anterior axillary line. the conventional method is the administration of intravenous opioids as a method of postoperative analgesia when the routine block cannot be performed due to a contraindication.


Eligibility criteria:
inclusion criteria: * 18-65 years old * asa i-ii-iii risk group * patients whose consent was obtained with an informed consent form * she will undergo a cholecystectomy operation * patients to be cooperative for sft test exclusion criteria: * \ 65 years * asa ≥ iv * pulmonary function test below 50% of the expected value * known diaphragm paralysis * body mass index \>30 * myocardial infarction within 1 month * dementia or confusion * lack of cooperation * people with respiratory diseases * congestive heart failure * unstable hypertension * thoracoabdominal surgery

Keywords: postoperative pain plane block pulmonary function
hyperarc registry study

Conditions: Brain Metastases; CNS Neoplasm; CNS Disorder, Intracranial

Summary: the hyperarc registry is designed to collect data from which the efficacy of the hyperarc procedure can be assessed and compared to alternative treatments.

a significant percentage of newly diagnosed cancer patients will develop brain metastases. for many of these patients, stereotactic radiosurgery (srs) is recommended as a primary treatment option. concerns about complexity, patient safety, cost, and human resources can make srs challenging. hyperarc radiotherapy addresses these challenges by introducing key technology and workflow elements to streamline multi-leaf collimator-based, non-coplanar srs. hyperarc is designed to deliver srs treatments from the truebeam linear accelerator platform. the hyperarc registry is designed to collect data from which the efficacy of the hyperarc procedure can be assessed and compared to alternative treatments.

Eligibility criteria:
inclusion criteria: * received or scheduled to receive treatment using the hyperarc treatment method * age of legal adult according to local law * signed informed consent form, or, informed consent waived by the local ethics board/institutional review board exclusion criteria: * none, apart from not meeting inclusion criteria

Keywords: stereotactic radiosurgery
a study of the effects of intravenous magnesium sulphate on anaesthesia and analgesia in elective general surgery patients

Conditions: Pain, Postoperative; Pain, Acute; Pain, Nociceptive; Analgesia; Magnesium

Summary: the aim of this double-blind randomized study will be to evaluate the effect an intravenous infusion of magnesium has on recovery outcomes after elective laparoscopic cholecystectomy

magnesium consists one of the most important electrolytes of the human body, producing effects in various systems, one of them being the central nervous system. it has been shown that the administration of intravenous magnesium sulphate during anesthesia can significantly reduce the requirements for anaesthetic and analgesic agents, perioperatively, and improve the quality of post anesthetic recovery. the present study will examine the effect of administering intravenous magnesium sulphate during anesthesia in patients undergoing elective laparoscopic cholecystectomy surgery. this is a single centre, double-blinded, randomised controlled trial in an adult population, taking place in a tertiary medical centre in athens. the study consists of three comparison groups of equivalent population, produced by double blinded randomisation. each comparison arm will be administered a different regimen of magnesium sulphate/placebo. during the perioperative time, depth of anaesthesia will be monitored using the bispectral index, (bis™) and the nociceptive level with nociception level index (nol®). dosing of the anaesthetic agent, desflurane, as well as of the analgesic medication, remifentanil, will be adjusted according to the prior indices. patients included in the study will be monitored in the pacu and the surgical ward for the first 24 hours, postoperatively. primary outcomes include the requirements for anaesthetic and analgesic agents, time to emergence, time to extubation, time to recovery, quality of recovery variables, pain scores during the first 24 hours and adverse effects and/or complications of magnesium administration. ethical approval for this trial has been granted by the ethics committee of the hospital.

Eligibility criteria:
inclusion criteria: * adult patents * american society of anesthesiologists (asa) class i-iii * elective laparoscopic cholecystectomy exclusion criteria: * body mass index (bmi) \>35 kg/m2 * systematic use of analgesic agents preoperatively * chronic pain syndromes preoperatively * neurological or psychiatric disease on treatment * pregnancy * severe hepatic or renal disease * drug or alcohol abuse * language or communication barriers lack of informed consent
stapled anastomosis versus hand-sewn for neonate with intestinal atresia

Conditions: Intestinal Atresia; Anastomotic Complication

Summary: neonatal intestinal atresia is the most difficult disease to apply stapled anastomosis. however, there are no high-quality clinical trial to verify its effectiveness. therefore, the investigators compared the outcomes of stapled and hand-sewn anastomosis in neonate with intestinal atresia.

intestinal anastomosis in neonates with intestinal atresia has traditionally been performed using the hand-sewn end-to-end approach. after the introduction of stapled functional end-to-end anastomosis (feea) in neonates and infants by powell in 1995, the procedure is gradually being accepted among pediatric surgeons. when treating intestinal atresia, great discrepancy between diameters of the proximal and distal intestine caused by disuse atrophy are often observed, which may cause difficulties and complications. to overcome size discrepancy, proficiency in performing anastomosis is required when using hand-sewn techniques. in theory, stapled functional end-to-end anastomosis does not require a special technique and does not impair the passage of intestinal contents immediately after completion because the side-to-side nature of the procedure retains the unique diameter of the target intestine and preserves patency. stapled side-to-side functional end-to-end intestinal anastomosis is a potentially useful technique that is not affected by intestinal size discrepancy and does not require specialized surgical experience.to date, there have been a few studies about the safety and efficacy of stapled anastomosis in neonates and infants, which reported the efficacy of stapled over hand-sewn anastomosis, including shorter operative time, time to full feeding and hospitalization, and no difference in adverse outcomes between both types of anastomoses. these studies compared the clinical outcomes in neonates and infants. however,there are no high-quality clinical trials to verify its effectiveness. therefore, the investigators compared the outcomes of stapled feea and hand-sewn anastomosis in neonate with intestinal atresia.

Eligibility criteria:
inclusion criteria: * patients were eligible if they were between 1 day and 30 days of age, and if they suffered from intestinal atresia. exclusion criteria: * these patients were complicated with intestinal perforation and peritonitis, instability of vital signs. * stapled anastomosis could not be performed when the intestinal lumen could not admit a 22-fr soft catheter.

Keywords: stapled anastomosis hand-sewn anastomosis intestinal atresia neonate
active screening of latent tuberculosis infection in school contacts of active tuberculosis patients

Conditions: Tuberculosis; Latent Tuberculosis Infection

Summary: the goal of this observational study is to investigate the proportion of mycobacterium tuberculosis (mtb) infection in school contacts of active tuberculosis (atb) patients. the main questions it aims to answer are: * the proportion of mtb infection among school contacts of atb patients * risk factors related to tuberculosis (tb) infection * health economic evaluation of screening strategy


Eligibility criteria:
inclusion criteria: * 13 years old or above; * students in junior middle school, high school and university; * close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory); * himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent. exclusion criteria: * current clinical or sputum culture confirmed active tuberculosis * have completed a full course of treatment for atb or ltbi

Keywords: latent tuberculosis active screening
cow milk fat obesity prevention trial

Conditions: Obesity, Childhood

Summary: cow's milk is a dietary staple for children in north america. though clinical guidelines suggest children transition from whole (3.25% fat) milk to reduced (1%) fat milk at age 2 years, recent epidemiological evidence supports a link between whole milk consumption and lower adiposity in children. the purpose of this trial is to determine which milk fat recommendation minimizes excess adiposity and optimizes child nutrition and development. comfort will be a parallel group randomized controlled trial among children aged 2 to 4 years participating in the target kids! practice-based research network. children will be randomized to receive one of two usual care nutritional recommendations: 1) a recommendation to consume whole milk, or 2) a recommendation to consume reduced (1%) fat milk. the primary outcome is body mass index z-score (zbmi); secondary outcomes will be cognitive development (using the ages and stages questionnaire), vitamin d stores (serum 25-hydroxyvitamin d), cardiometabolic health (glucose, hscrp, non-hdl, ldl, triglyceride, hdl and total cholesterol, insulin, and diastolic and systolic blood pressure) and sugar sweetened beverage intake (measured by 24-hour dietary recall). outcomes will be measured 24 months post-randomization and compared using ancova, adjusting for baseline measures. this trial will contribute to nutrition policy for children in effort to reduce childhood obesity using a simple, inexpensive and scalable cow's milk fat intervention.


Eligibility criteria:
inclusion criteria: * healthy by parental report; * 1.5 to 2.99 years of age * involved in a target kids! academic pediatric or family medicine group. exclusion criteria: * prader-willi syndrome or other syndrome associated with obesity * severe development delay * children who are from families without verbal communication in english or french * failure to thrive (with zbmi values ≤ -2 are unlikely to benefit from obesity prevention) * siblings of trial participants as families may share milk * will not consume cow's milk by choice, lactose intolerance or allergy.

Keywords: milk fat cohort-embedded
a study of ag-80308 in dry eye patients

Conditions: Dry Eye Disease

Summary: this is a multicenter, double-masked, randomized, parallel-group study with topical ag-80308 eye drops in dry eye patients.


Eligibility criteria:
inclusion criteria: 1. male or female, 18 years of age or older at the screening visit 2. diagnosis of dry eye disease in both eyes with or without meibomian gland disease exclusion criteria: 1. participation in any investigational study within 30 days prior to baseline or exposure to an investigational drug must be fully washed out (at least 5 half-lives) 2. any ocular infection or inflammation within 30 days prior to the screening visit 3. corneal disorder or abnormalities other than dry eye disease that impact normal spreading of the tear film (except superficial punctate keratitis) 4. history of chronic ocular allergy, systemic lupus erythematosus, rheumatoid arthritis, corneal ulcer/erosions, uveitis or dry eye due to stevens johnson syndrome, irradiation, alkali burns, cicatricial pemphigoid or vitamin a deficiency. 5. use of contact lenses in either eye within 14 days of screening visit or planned use during the study 6. use of the dry eye and/or meibomian gland disease medications/procedures within 2 to 8 weeks prior to the screening visit
muslim americans reaching for health and building alliances (marhaba): patient navigation intervention to increase breast and cervical cancer screening among muslim women in new york city

Conditions: Breast Cancer; Cervical Cancer

Summary: studies have reported muslims in the us and nyc face numerous language and healthcare access barriers. this is a randomized randomized controlled design will be used to test the efficacy of a patient navigation (pn) intervention to increase participation in breast and/or cervical cancer screening among muslim women age 40 - 75 years living in nyc. study participants will be randomized to an lay health workers (lhw) led small media intervention arm (sm-lhw) or a lhw-led patient navigation plus small media intervention arm (pn-lhw). a specific aim of the study is to develop, implement and evaluate the efficacy of a two-arm, randomized control trial designed to increase receipt of breast and/or cervical cancer screening among muslim women aged 40 -75 years in new york city (nyc).

the goal of this study, entitled muslim americans reaching for health and building alliances (marhaba), is to evaluate the effectiveness of a culturally patient navigation (pn) intervention designed for muslim women to increase breast and cervical cancer screening participation.

Eligibility criteria:
inclusion criteria: * self-identify as muslim * female * residence in a nyc borough * self-report as having received a mammogram more than two years ago and are age 40-74 years * self-report having received a pap test more than three years ago and are age 40-65 years exclusion criteria: * report a past or current diagnosis of breast or cervical cancer * report having had a hysterectomy * report having had breast reconstructive surgery

Keywords: muslim americans patient navigation breast cancer cervical cancer