Kornimate/medical-research-clean huggingface dataset:
balance and anti-epileptic drugs

Conditions: Epilepsy

Summary: patients with epilepsy exercise less than the general population. a barrier to exercise may be the effect of antiepileptic drugs on balance and reaction time. this proposal endeavors to study the effect of two common antiepileptic drugs (levetiracetam and lamotrigine) on balance and reaction time using a wii balance board and reaction time test. this will be tested at descending doses in an epilepsy monitoring unit. drug levels will be monitored, as well as center of pressure, and reaction time.

patients with epilepsy (pwe) exercise less compared to the general population. one barrier to participation in exercise is the subtle effect of anti epileptic drugs (aeds) on balance and reaction time. information on these measures in pwe is scarce, although previous data does suggest a detrimental effect. the objective of this trial is to study balance and reaction time in patients taking common aeds. the investigators plan to study the effect of levetiracetam and lamotrigine on balance and reaction time. by studying patients in the epilepsy monitoring unit who are undergoing medication taper and withdrawal, the investigators can observe the effects of varying doses of these drugs within a single subject and also compare these data points to age matched controls. a wii balance board (wbb) will be used to measure balance. it is hypothesized that levetiracetam and lamotrigine will elicit a dose-dependent, detrimental effect on balance and reaction time. patients admitted to the epilepsy monitoring unit who are currently taking levetiracetam or lamotrigine either in monotherapy will be recruited for the study. the target enrollment is 20 pwe, and 20 healthy controls. for the pwe in the study, baseline aed blood levels will be obtained at baseline. the wbb has cells which detect load shifts in the body. participants will stand on the wbb and remain as steady as possible. first on both feet with eyes open for 30 seconds, and then on both feet with eyes closed for 30 seconds, then on one foot with eyes open for 10 seconds, and then on one foot with eyes closed for 10 seconds. each task will have 3 trials, with adequate break between. visit 2 will occur following weaning of aeds. the investigators will measure center of pressure and reaction time testing similar to visit one. blood aed levels will be checked at three half lives of the medication. this will be taken within 8 hours of visit 2.

Eligibility criteria:
inclusion criteria: * focal or generalized epilepsy * on a stable dose of aeds defined by no medication changes within the last month. * on levetiracetam or lamotrigine monotherapy exclusion criteria: * inability to stand independently for 30 seconds * peripheral neuropathy * history of stroke or previous brain surgery * seizure within last 24 hours
walking impairment questionnaire in pad

Conditions: Peripheral Artery Disease

Summary: purpose is to test and validate a new questionnaire (the welch questionnaire) to estimate walking capacity in patients with claudication

questionnaires (welch and wiq) submitted to patients referred for treadmill walking test comparison of sore to mwd on treadmill. comparison with wiq will be performed

Eligibility criteria:
inclusion criteria: * informed consent signed, french language fluent patients exclusion criteria: * rejection of the questionnaire

Keywords: questionnaire peripheral artery disease exercise
genetic investigation of cancer predisposition

Conditions: Genetic Predisposition; Cancer

Summary: clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.

genetic screening will be performed on dna (and/or rna) isolated from collected samples from affected individuals by whole exome sequencing or rna sequencing using in-house pipeline to identify candidate sequence variants. these variants will be tested for segregation with the phenotype in other relatives (affected/unaffected). candidate variants will be subjected to additional downstream analysis, to be guided by the actual type of gene/variant.

Eligibility criteria:
inclusion criteria: 1. any age 2. meets at least one of the following: 1. personal history (with documented diagnosis) of cancer before the age of 50 2. personal history of more than one primary cancer 3. documented diagnosis of cancer and family history of that same cancer type or multiple other cancers that do not fit classical criteria of hereditary cancer syndromes 4. documented diagnosis of a rare cancer and family history of rare cancers that do not fit classical criteria of hereditary cancer syndromes 5. there is the same type of cancer in several generations of a family 6. documented diagnosis of multicentric cancers (e.g bilateral cancers in paired organs, or multifocal cancers in single organs) that usually occur as single lesions when presented sporadically 7. early onset cancer (before the age of 50, or breast cancer before age 45) and family history of early onset cancer capable of providing access to detailed medical records and family history of cancer exclusion criteria: 1. established genetic diagnosis of a known hereditary cancer syndrome that is compatible with the clinical presentation 2. incarcerated

Keywords: genetic analysis early diagnosis
plantar fasciitis foot insole

Conditions: Plantar Fasciitis

Summary: the hypothesis to be tested is that the use of total contact insoles for six months reduces foot pain, improves function and quality of life of patients diagnosed with plantar fasciitis.

patients diagnosed with plantar fasciitis, foot pain with vas between 3 - 8 for walk, over 18 years, regardless of gender who agreed to participate and signing the consent form. pacietes we excluded patients with other symptomatic lower limb musculoskeletal diseases, diabetes mellitus, rigid deformities in the feet, which made use of insoles, physiotherapy or injections in feet and ankles in the last three months, and previous surgery or planned within the next twelve months.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with a diagnosis of pf and foot pain while walking ranging from 3 to 8 points on a 10-point pain scale were analyzed exclusion criteria: * patients with other musculoskeletal conditions in symptomatic lower limbs, inflammatory conditions of the central or peripheral nervous systems, diabetes mellitus or an inability to walk.

Keywords: plantar fasciitis foot pain insoles foot function electronic baropodometer plantar pressure gait analysis
respiratory distress and elective cesarean section at term

Conditions: Respiratory Distress Syndrome

Summary: cesarean section is a life-saving surgical operation for women and their newborns. in egypt, caesarean sections are over-utilized. the rate increased from 27.6 % in 2008 to 51.8 % in 2014, reaching 72.2 % in 2021. cesarean section has been associated with an increased risk of adverse respiratory outcomes in newborns. studies have shown a higher risk of neonatal respiratory distress syndrome in babies born by elective cesarean section, especially at 37 and 38 weeks' gestation. neonatal respiratory distress syndrome is one of the leading causes of neonatal morbidity and mortality. many non-invasive tools have been used to predict the risk of neonatal respiratory distress syndrome. most of these studies assessed the predictors of neonatal respiratory distress syndrome in low birth or preterm fetuses, and none of them talked about neonatal respiratory distress syndrome with term fetuses. doppler velocimetry provides a simple and non-invasive method to assess the fetal pulmonary circulation. pulmonary doppler velocimetry is used to determine lung maturity in complicated pregnancies. the magnitude of neonatal respiratory distress syndrome among term neonates depends on the availability of medical services and the number of trained medical personnel. so, there is a need to assess the rate and predictors of eonatal respiratory distress syndrome among low-risk term fetuses delivered by cesarean section to give attention and appropriate intervention for these predictors to decrease the morbidity and mortality associated with eonatal respiratory distress syndrome.


Eligibility criteria:
inclusion criteria: 1. maternal age of 20-39 years. 2. women with singleton pregnancy ≥ 37 weeks 3. pregnant women who received corticosteroid to enhance lung maturity and will be subjected to elective cesarian section (before onset of labour) within 1 week after administration of corticosteroid exclusion criteria: 1. women with oligohydramnios or polyhydramnios. 2. women with underlying disease requiring corticosteroids. 3. pregnant women with any medical disorders such as hypertension, diabetes, renal diseases, antiphospholipid syndrome, intrauterine growth restriction, preterm premature rupture of membrane, placenta previa, antepartum haemorrhage, on anticoagulant thereby. 4. women with confirmed fetal malformation. 5. women who will refuse to participate.
a study of ibi112 in chinese patients with psoriasis who were previously treated with biologics

Conditions: Psoriasis

Summary: this is a multicenter, open-label study aim to evaluate the efficacy and safety of ibi112 in chinese participants with plaque psoriasis who were treated with biologics and switched to ibi112. the study will enroll 160 participants who were diagnosed with plaque psoriasis. the whole study consists of 4 weeks of screening, 32 or 36 weeks of treatment and a safety follow-up visit at week 44.


Eligibility criteria:
inclusion criteria: 1. 18 to 75 years old; 2. evaluated suitable for continuing biologic therapy for plaque psoriasis by the investigator; 3. received previous biologic therapy with at least 4 months. exclusion criteria: 1. diagnosed with guttate psoriasis, pustular psoriasis, erythrodermic psoriasis, or drug-induced psoriasis (e.g., psoriasis caused by beta blockers, calcium channel inhibitors, etc.) at screening; 2. previously treated with ibi112 or other il-23 inhibitors; 3. treated with two biologics for psoriasis within 4 months prior to screening; 4. treated with topical therapy for psoriasis within 2 weeks prior to the first dose administration, or treated with systemic non-biological agents or phototherapy within 4 weeks prior to the first dose administration; 5. treated with natalizumab, or b/t cell regulators (e.g., rituximab, abatacept, or visilizumab) within 12 months prior to the first dose administration; 6. not willing to avoid constant sunshine and other ultraviolet light sources exposure during the study; 7. treated with an investigational biologic within 6 months prior to the first dose administration, or any investigational therapy within 30 days, or an investigational drug within 5 half-lives, or currently participating in a clinical study.
telecoaching to improve physical activity in patients with obstructive sleep apnea

Conditions: Physical Activity; Obstructive Sleep Apnea

Summary: patients with obstructive sleep apnea (osa) are less physically active than healthy controls. first choice of treatment for osa is continuous positive airway pressure (cpap) therapy with an improvement in oxygen saturation and sleep. no improvement on physical activity has been shown. the current study would randomize patients in a standard care group (cpap) and an intervention group (cpap + telecoaching). telecoaching will be performed for 3 months, with physical activity assessment before, after 3 months and 12 years.


Eligibility criteria:
inclusion criteria: * ahi \> 15 events/hour, measured by polysomnography * \< 7,500 steps per day * willing to start cpap treatment * age between 18 and 65 years * signing the written informed consent exclusion criteria: * patients with neuromuscular diseases * patients with chronic obstructive pulmonary disease and interstitial lung disease * patients with cardiac failure and ischemic heart failure * patients with comorbidities which could interfere with a normal biomechanical gait pattern and the possibility of increasing physical activity * patients with mental disability making it impossible to understand the study protocol and the use of electronic devices.
a randomised open controlled parallel group study comparing norspan and tramadol

Conditions: Osteoarthritis

Summary: to evaluate the efficacy and safety of norspan versus tiperol retard among oa patients who are sub-optimally treated with current analgesic. those patients may benefit from treatment with a long lasting analgesic.


Eligibility criteria:
inclusion criteria: * oa diagnosis * bs11 greater than or equal to 4 at base line * not adequately pain relieved with 4,000 mg paracetamol daily exclusion criteria: * treated with high potent opioids for their oa pain * treated with a regular dose for greater than one week of tramadol, codeine or dextropropoxifene during the last three months * other chronic conditions requiring frequent analgesic therapy

Keywords: osteoarthritis norspan versus tramadol randomised efficacy and safety oa pain of the hip and/or knee
validation of mystrength's macropersonalization engine

Conditions: Depression, Anxiety; Trauma

Summary: this is a study to validate mystrength's macropersonalization algorithm. specifically, the study seeks to answer: does mystrength's macropersonalization algorithm match what a clinician would offer as a diagnosis following an expert assessment? participants will be treatment-seeking adults, ages 18 to 65, recruited from an evidence-based group psychotherapy practice. participants will be asked to complete mystrength onboarding and a clinician-conducted initial assessment. inter-rater reliability will be assessed to determine the consistency between mystrength and clinician in primary focus area of digital program.

rationale and background: macropersonalization refers to the rules applied to a member's onboarding data that dictate their primary clinical focus and available interventions that will be recommended. macropersonalization is a new mystrength feature that is meant to enable mystrength's ability to deliver evidence-based stepped care. research questions: to examine the inter-rater reliability between mystrength's macropersonalization engine and expert clinical recommendations for members' primary clinical focus. study design: this is a one-arm, prospective study. population: study participants will be adults, ages 18 to 65, seeking therapy at an evidence-based psychotherapy group practice. data sources: anticipated data sources include members mystrength onboarding data, macropersonalization outputs, and clinician-administered clinical assessments. data analysis: a cohen's kappa will be generated for agreement between mystrength macro-personalization primary focus area and clinician diagnosis to fulfill the primary objective. conditional kappas based on stratification, as well as a logistic regression, will be used to determine whether demographics or treatment history are associated with concordance, and qualitative analyes will be used to describe sub-clinical or secondary focus areas associated with clinician diagnoses.

Eligibility criteria:
inclusion criteria: * aged 18 to 85, inclusive * able to read, write, and speak in english * has access to the internet to complete study procedures * currently engaged in therapy or has schedule an initial appointment with the pacific anxiety group exclusion criteria: * none

Keywords: sleep digital therapy
ultrasound-guided deep and superficial serratus anterior plane block

Conditions: Pain Management; Thoracotomy

Summary: this study evaluates the difference of deep and superficial serratus anterior plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

thoracotomy is known as one of the most painful surgery. thus, there is a development to reduce surgical stress in terms of operation technique, which is video-assisted thoracoscopic surgery. although it has reduced postoperative pain and complications compared with thoracotomy, vats is still quite painful operation. serratus plane block is a novel technique which provide analgesic effect for lateral chest wall by blocking lateral branch of intercostal nerve. two methods were proposed to target the top and bottom of the serratus anterior muscle. however, the difference of deep and superficial serratus anterior plane block during intraoperative period has not yet been studied. in this study, therefore, the investigators decided to assess the difference of deep and superficial serratus anterior plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

Eligibility criteria:
inclusion criteria: * a) american society of anesthesiologists (asa) physical status 1 or 2 * b) age 20-75 years * c) elective three port video-assisted thoracoscopic surgery (vats) lobectomy. exclusion criteria: * a) a history of drug allergy for opioids or local anesthetics * b) local infection at the injection site and systemic infection * c) coagulopathy * d) difficulty in understanding the study protocol * e) refusal to participate
contribution of hypnosis on image quality in cardiac mri

Conditions: Anxiety

Summary: the present project aims to explore the effect of a hypnosis session performed on a patient with anxiety during a cardiac mri examination on image quality.

cardiac magnetic resonance imaging (mri) is an activity of the bordeaux university hospital that continues to grow (+7.3% in 2021 compared to 2019) under the combined effect of the increase in activity of cardiology care channels and the extension of clinical indications for cardiac mri. indeed, cardiac mri has become an essential examination in the diagnosis of many heart diseases and is little practiced elsewhere in new aquitaine. the current delay for a cardiac mri is 3 and a half months. in this context, it is necessary to be efficient because any procedure failure, examination interruption or insufficient image quality can delay the diagnosis and therapeutic management of the patient for several months. numerous studies have shown that anxiety induces interruptions in the acquisition of mri images and repetition of sequences, thus prolonging the examination time. however, no study takes into account the specificity of cardiac mri, whose image quality is intimately linked to the patient's cooperation and to the synchronization of the sequences with the heart rhythm. hypnosis seems to be adapted to reduce the patient's anxiety, by allowing him to ignore the surrounding reality while remaining in relation with the attendant. the hypothesis is that by reducing patient anxiety through hypnosis, image quality in cardiac mri would be improved.

Eligibility criteria:
inclusion criteria: * anxious patient (anxiety score trait (baseline) and anxiety score state (situational) ≥ 46) and non-anxious patient (anxiety score trait and anxiety score state \< 46) requiring cardiac mri for diagnosis or follow-up of a cardiac pathology except the patients with cardiac arrhythmias or irregular heartbeats. * 18 years and older * highly effective contraception for women of childbearing potential, maintained during research procedures * informed consent * affiliated or beneficiary of health insurance exclusion criteria: * contraindications to mri and gadoline contrast medium * hearing impaired patients * patients who do not speak french * women who are pregnant or lactating * inability to agree to participate to the study * patient under legal protection

Keywords: hypnosis cardiac mri anxiety
multimodal prehabilitation for resectable gastric cancer

Conditions: Stomach Neoplasm

Summary: surgical resection is the mainstay for gastric cancer. surgical stress response, like insulin resistance and catabolism, is inevitable and is a risk factor for postoperative outcome. to cope with this stress, the enhanced recovery protocol has been proposed and successfully implemented in clinical practice. recently, prehabilitation have attracted increasingly attention, which is the preoperative part of enhanced recovery pathway. prehabtilitation are bundles of evidenced elements in order to improve patient's functional capacity. patients with gastric cancer are usually suffered from nutritional risk, anxiety and frailty. in this trial, we investigate whether multimodal prehabilitation (exercise, nutrition and psychological support) could improve patient's functional status to better tolerate surgical trauma.


Eligibility criteria:
inclusion criteria: * pathologically confirmed gastric cancer, clinical i-iii tnm stage (ajcc 8th edition); * will receive curative-intent surgery; * life expectance \> 6 months; exclusion criteria: * gastric stump cancer or combined with other malignances; * nyha iii, nyha iv; * inability to swallow, with gastrostomy, or inability to move because of orthopedic disease or neuromuscular disease; * psychiatric disorders, copd, end-stage hepatic or renal disease, uncontrolled cardiac arhythmia or uncontrolled hypertention; * receiving immunosuppressive therapy; * emergency surgery because of tumor bleeding or tumor perforation;

Keywords: gastric cancer
home-based treatment of patients with chronic obstructive pulmonary disease (copd)

Conditions: COPD

Summary: we want to improve the treatment of patients suffering from copd (3-4) by early medical intervention in the patients home. a close cooperation between the hospital and the primary healthcare system will hopefully reduce hospitalisation, drug consumption and improve quality of life. following up from the hospital and the primary healthcare in cooperation may lead to earlier detection and treatment of exacerbations in copd. the main outcome variable will be number of hospitalizations assessed simply by counting. the second objective will be quality of life and activation assessed by different questionnaires included in st.george´s respiratory questionnaire.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd (iii-iv) * receive help from homecare nurse * not suffering from any other serious disease, with expected lifespan less than 6 months exclusion criteria: -

Keywords: copd home-based treatment early intervention