Kornimate/medical-research-clean huggingface dataset:
efficacy of ear neurostimulation for adolescents with functional abdominal pain

Conditions: Functional Disorder of Intestine; Nausea Persistent

Summary: this study evaluates the effectiveness of a neurostimulator applied to the outer ear for adolescents with functional gastrointestinal disorders. the neurostimulator provides nerve stimulation to a branch of the vagus nerve which is thought to be involved in transmission of pain signals. half of the study subjects will receive an active nerve stimulator while the other half will receive an inactive one.

the vagus nerve innervates the gastrointestinal tract and influences the autonomic nervous system. it is thought to carry signals of discomfort and nausea to the brain where it is interpreted. the autonomic nervous system may be in imbalance in patients with functional gastrointestinal disorders. by stimulating a branch of the vagus nerve in the outer ear, this study aims to improve symptoms and quality of life in adolescents with functional abdominal pain with or without nausea. subjects will be randomized into two groups: 1) neurostimulation versus 2) sham. they will receive either an active or non-active (sham group) device for 5 days each week x 4 weeks total. pain, nausea, anxiety, quality of life, potential side effects and overall symptom improvement will be monitored weekly for the entire study as well as after the study is completed.

Eligibility criteria:
inclusion criteria: * adolescents with a major complaint of abdominal pain (minimum 3/10 in severity) with or without nausea (minimum 3/10 in severity) of unclear etiology, who are english-speaking and willing to participate and consent to the study and who have a parent willing to participate. * patients with symptoms of minimum three times per week for a duration of two months or greater * intact external ear that is free of infection or severe dermatological conditions. * stable vital signs for their respective age exclusion criteria: * medically complex children or those who take a medication or suffer from an organic disease that can explain symptoms will be excluded from participation. * children or parents, who have developmental delay, will be excluded due to difficulties in accurately completing the questionnaires and assessing symptoms. * history of seizures * currently implanted electrical device * orthostatic hypotension
a perianal abscess cavity packing vs no packing.

Conditions: Perianal Abscess; Ischiorectal Abscess

Summary: this prospective randomized trial will be conducted in all patients undergoing packing or no packing for perianal abscess cavity after incision and drainage, for 6 months after approval from irb in surgical unit iii, civil hospital karachi. patient will be selected simple random sampling technique based on inclusion criteria. patient will be assessed for post-operative pain, healing of cavity and recurrence of abscess. at first time of debridement pus or tissue will be sent for culture and sensitivity, meanwhile broad-spectrum antibiotic will be started. questionnaire will be filled by pi for post-operative pain, recurrence of abscess, quality of life, wound healing, post operative fistula in ano and chronic post surgical pain either due to packing or no packing.

this is an experimental randomized control trial will start 6 months after approval from institution review board. all patients with perianal abscess after incision and drainage cavity will be either packed or not after informed consent. pack will be changed daily as regular dressing till healing occurs. packing reduces bleeding and heals cavity by effect of dressing solution in which gauze is soaked. other group with dressing will be changed daily and will be assessed for healing week. there is no pain in simple dressing applied over cavity. patient will receive broad spectrum antibiotics according to pus or tissue culture. during this period, laboratory investigation cbc, crp will be sent to check the response. sits bath will be advised to both groups. post-operative pain, cavity healing will be assessed by faculty.

Eligibility criteria:
inclusion criteria: * age greater than 18 years * age less than 70 years * perianal abscess exclusion criteria: * suspected inflammatory bowel disease * fournier's gangrene * horseshoe/bilateral abscess
twinrix alternative schedule study

Conditions: Antibody Response After Vaccination

Summary: to compare the efficiency of protection against hepatitis-b virus by administration of the combined vaccine against hepatitis a and b using the schedule 0-1-12 months against the schedule 0-1-6 months. 1. to compare the seroconversion (\>= 1 iu/l) and seroprotection (\>= 10 iu/l) rate at month 6,7,12 and 13. 2. to compare the distribution of anti-hbs at these different moments.


Eligibility criteria:
inclusion criteria: * 18 years or older; * a good physical condition as confirmed by history and physical examination at entry of the study; * for female participants who could become pregnant in the course of the study a contraceptive programme is foreseen; * all participants have provided written informed consent. exclusion criteria: * employees occupationally exposed to hepatitis b virus * other exclusion criteria listed for the vaccine (licensed vaccine): * each acute disease at the inclusion in the study; * a history of hypersensibility to one of the components of the vaccine; * simultaneous participation in another clinical trial

Keywords: combined hepatitis a and b vaccine hepatitis b virus immunity
difference of tear ferning between women with and without menopausal.

Conditions: Dry Eye Syndromes

Summary: application of tear ferning test for clinical dry eye diagnosis and menopause

analyzing the difference in tear ferning structure between women pre and post-menopause with and without hormone replacement therapy (hrt). tear and blood samples were collected for a menopause-related enzyme-linked immunosorbent assay. tear volume, tear osmolarity, intraocular pressure, and tear break-up time were also measured for comparison.

Eligibility criteria:
inclusion criteria: * aged between 20 and 65 years exclusion criteria: * no evident ocular diseases such as cornea, cataracts, vitreous degeneration, glaucoma, and retinopathy. * belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)

Keywords: dry eye diagnosis tear ferning menopause
investigating kinematic and electromyographic changes after sci and their relation to clinical and functional outcome

Conditions: Spinal Cord Injury

Summary: the study aims at discerning specific gait patterns and elucidating locomotor control of spinal cord injured patients in order to find sensitive kinematic and electromyographic outcome measures that are able to reveal information on underlying mechanisms of normal and aberrant gait control and its recovery over time. these measures may also be used to compare the outcome across different neurological disorders.


Eligibility criteria:
inclusion criteria: patients: we will monitor patients who were admitted to the spinal cord injury center of the university hospital balgrist. we will record patients with various aetiologies, grades of impairment and types of spinal cord lesions. patients need to have minimal voluntary motor capacities: the motor scores of the key muscles according to the asia classification (www.asia-spinalinjury.org) should be at least 3 for extensor muscles and 2 for flexor muscles. written informed consent is required. control subjects: healthy subjects, written informed consent. exclusion criteria: patients: comorbidities which influence or inhibit gait or upper-limb motion (e.g. peripheral nerve lesions). orthostatic problems that greatly impair upright body position. mental illness, cognitive impairments. control subjects: neurologic disease, walking disabilities, mental illness, cognitive impairments
effect of tourniquet abstention on pain reduction in venous sampling in the elderly people

Conditions: Venous Puncture

Summary: this prospective study evaluates the effect of abstaining from tourniquets on pain reduction during the venous puncture of the elderly people.

almost 3 million people aged 70 and over are hospitalized once or more each year. the implementation of multiple treatments in these fragile patients, often poly-pathological requires a regular biological monitoring. for these patients, samples must be taken on average every two days. this population often has a fragile venous capital due to reduced skin elasticity, undernutrition more or less associated with dehydration, the use of certain venous-toxic treatments and / or repetition of the gesture taking into account the monitoring biological closely related to long-term therapies. with the aim of well-treatment and well-being, the reduction of patient pain is one of the major concerns of caregivers and in particular pain induced by treatment. in children, the practice of harvesting without tourniquet is already frequent (18) and our preliminary study has confirmed us on the tourniquet as one of the acts responsible for the pain that the caregiver can possibly abstain. no study had been conducted on this subject in the adult population and more particularly the elderly population. this prospective study evaluates the effect of abstaining from tourniquets on pain reduction during the venous puncture of the elderly people.

Eligibility criteria:
inclusion criteria: * ≥ 75 years and over, * hospitalized in internal medicine or geriatric department, * for which the 2 upper limbs are accessible to venous puncture (due to the multiple attempts that may be necessary to take a sample during the hospitalization), * for which at least one vein is visible or palpable on an upper limb, * without venous puncture since admission in the department, * patient who did not receive a topical anesthetic before the venous puncture (emla type) * communicating patient, able to assess their pain on a digital scale, * patients with affiliation to a social security system or beneficiary , * written informed consent (ic) obtained. exclusion criteria: * patient already included, * previous pain localized to the upper limbs, * hematoma at the planned site of skin-vascular breakage, * hemiplegic or quadriplegic patient, * patient with lymphedema in the upper limbs, * patient with behavioral disorders that may interfere with the proper functioning of the sampling, * patient with cognitive impairment preventing understanding of the study and adequate assessment pain (codex cognitive score of category c or d), * patient placed under legal protection (guardianship).

Keywords: venous puncture tourniquet pain elderly people
safety and efficacy of left atrial appendage occlusion devices

Conditions: Atrial Fibrillation

Summary: atrial fibrillation (af) is the most common cardiac rhythm disorder in clinical practice. in the last two decades the number of hospitalizations for af has increased two- to three-fold. more than 6 million people worldwide suffer from atrial fibrillation (af), a cardiac disorder that results in systemic emboli. patients with af are 5 times more likely to have a stroke compared with those without af. this registry will collection information on two devices that are used to treat af. the watchman and lariat. the differences in techniques and subsequent effects of the two devices on outcomes related to af has not been studied. this study will look to compare the two devices to see how the outcomes may vary.


Eligibility criteria:
inclusion criteria: * patients who have had a lariat laa device occlusion exclusion criteria: * patients who have pfo/asd/critical carotid artery (\>70% blockage) disease and hemorrhagic strokes

Keywords: atrial enlargement left atrial appendage
applied relaxation for vasomotor symptoms

Conditions: Menopause; Hot Flashes

Summary: the objectives of this study are to compare frequency and severity of moderate to severe vasomotor symptoms in postmenopausal women treated with applied relaxation (ar) with an untreated control-group (cg) and to investigate if health related quality of life improve in the ar-group compared to an untreated cg.to study if salivary cortisol excretion would change within the ar treated group compared with the control group.

approximately 70% of women in europe and north america experience hot flashes and night sweats during the climacteric period. many women abstain from hormonal therapy because of side effects or contraindications such as breast cancer or thrombosis. different alternative therapies for alleviation of hot flashes are described in the literature. both pharmacological treatments, different types of natural remedies, acupuncture, life-style changes and mind-body therapies are suggested as promising therapies. applied relaxation (ar) is a technique influenced on cognitive behavioral therapy (cbt) using coping mechanism and conditioning. previous study with healthy postmenopausal women showed promising results on hot flash frequency with an average decrease of more than 70 % with persisting effect three months after therapy and also hrqol significantly increased probably due to better sleep and diminished vasomotor symptoms. but the method must be further investigated before strong evidence-based conclusion can be drawn. cortisol is a potent stress hormone regulated by the hypothalamic-pituitary axis. the factors underlying how alternative treatment works and the mechanism underlying improvements in symptoms are not fully understood.

Eligibility criteria:
inclusion criteria: * postmenopausal women (at least 12 months since last menstrual bleeding occurred or in previously hysterectomised women a serum follicle-stimulating hormone (s-fsh) defined as postmenopausal level according to references at the local laboratory) * more or equal to 7 moderate to severe hot flashes or more or equal at 50 hot flashes per week according to a two-week screening diary * ability to understand and speak swedish * freely given informed consent exclusion criteria: * unstable thyroid or other metabolic disease * treatment with hormone therapy (ht) or other complementary- or alternative treatments treatment for menopausal-related symptoms * treatment with psychopharmacological drugs and/or sedatives d-un-treated psychiatric disease * frequently exercising women (≥ 2h high-intensity activities/week)

Keywords: hot flashes vasomotor symptoms menopause applied relaxation health related quality of life salivary cortisol
adipokines and ghrelin concentrations in different stages of anorexia nervosa

Conditions: Anorexia Nervosa; Adipokines

Summary: the aim of this study is to determine serum concentrations of adiponectin (apn), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

objective: the aim of this study is to determine serum concentrations of adiponectin (apn), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters. design: the study group is composed of four groups. group1: treatment-naïve patients with a recent diagnosis of an (n:19), group 2: the weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), group 3: recovered patients with a previous history of an but normal menstrual cycles and body weight at the present time (n:10), group 4: control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). venous blood was obtained for measurements of biochemical parameters, apn, leptin and ghrelin and body composition was determined by bioimpedance analysis.

Eligibility criteria:
inclusion criteria: * diagnosis of anorexia nervosa for group 1-3 * constitutionally thin healthy subjects for group 4 exclusion criteria: * medical or psychiatric diagnosis other than anorexia nervosa, * history of gastrointestinal disease for group 1-3 * history of eating disorder or gastrointestinal or psychiatric disease for control group

Keywords: anorexia nervosa adipokines ghrelin fat mass
front-line therapy with carfilzomib, lenalidomide, and dexamethasone induction

Conditions: Multiple Myeloma

Summary: the purpose is to determine whether induction and consolidation treatment with carfilzomib, lenalidomide and dexamethasone (crd), within an intensive program, warrant further investigation in clinical trials.

the primary objective is to evaluate the scr rate of the combination of carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma patients at the completion of consolidation therapy. it's a multicenter, open label, non randomized, phase ii study. 46 patients will be enrolled. induction: 4 cycles of 28 days with carfilzomib/lenalidomide and dexamethasone stem cell harvest: high dose cyclophosphamide with intensification consolidation: 4 cycles of 28 days with carfilzomib/lenalidomide and dexamethasone maintenance : lenalidomide 13 cycles of 28 days

Eligibility criteria:
inclusion criteria: * patients diagnosed with multiple myeloma based on the new international myeloma working group * subjects must have symptomatic myeloma with at least one crab criteria * subjects must not have been treated previously with any systemic therapy for multiple myeloma exclusion criteria: * pregnant or lactating females * evidence of mucosal or internal bleeding and/or platelet refractory * acute active infection requiring treatment * treatment by localized radiotherapy if the interval between the end of radiotherapy and initiation of protocol therapy lower than 2 weeks * treatment by corticosteroids if exceed the equivalent of 160 mg of dexamethasone in a 2-week period before initiation therapy * subjects not eligible for high dose therapy

Keywords: multiple myeloma carfilzomib lenalidomide dexamethasone patient up to 65 years initial management
virtual reliability system for visual spatial attention evaluation in stroke patients

Conditions: Stroke Sequelae; Neglect, Hemispatial

Summary: the researchers designed a software based on a head-mounted displays for virtual reality (hmd-vr) to evaluate the reaction time to stimuli presented at right or left visual field. the study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left each) and 100 age-matched healthy controls. the participants will conduct a simple reaction time task in vr, with stimuli designated in the left or right hemi-field. the stroke patients will also received traditional tests for hemi-neglect. test-retest reliability of the assessment will be conducted in a subset of the control group. the stroke patients will be followed in 3-4 weeks.

the researchers designed a software based on a head-mounted displays for virtual reality (hmd-vr) to evaluate the reaction time to stimuli presented at right or left visual field. the study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left hemisphere each) and 100 age-matched healthy controls. the participants will conduct a simple reaction time task in vr, with stimuli designated in the left or right hemi-field. the stroke patients will also receive traditional tests for hemi-neglect. the researchers will also collect the demographic data, cognition function and daily activity function. test-retest reliability of the assessment will be conducted in a subset of the control group. the stroke patients will be followed in 3-4 weeks. the researchers will compare the results of a traditional hemi-neglect tests and vr-based tests and their changes in two occasions.

Eligibility criteria:
inclusion criteria for stroke patients: 1. aged at least 20 years old 2. diagnosed with stroke involving unilateral mca and aca territory 3. with unilateral upper limb with normal function 4. neurologically and medically stable. inclusion criteria for control group: 1) healthy adults, age-matched to stroke patients exclusion criteria for both groups: 1. with history of neurological or psychiatric conditions other than stroke; 2. significant cognitive or speech problems that cause difficulties to cooperate with testing; 3. significant visual problems (such as color blindness, visual loss, cataract, glaucoma or other major eye condition) 4. upper limb musculoskeletal disorders to cause difficulties to use the keyboard or controller; 5. history of seizure, vestibular dysfunction or vertigo 6. can't tolerate hmd-vr

Keywords: attention hemineglect virtual reality reaction time
study to investigate daily symptom variability, symptom effects on morning activities of chronic obstructive disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the primary objective of this non-interventional study is to evaluate daily symptom variability in copd patients. the secondary objectives are; to evaluate effects of copd symptoms on the morning activities of patients, to determine therapeutic expectations of patients and physicians in copd, to determine which and how frequent non-drug approaches are recommended in order to prevent copd exacerbations, to define copd patient profiles about the below-mentioned issues: demographic characteristics, disease characteristics, concomitant diseases and implemented drug treatments. all patients, who apply to the study physicians and fulfill all patient selection criteria during patient enrolment period, will be included. patients, who provide all of the following measures will be included in the study: to apply to a physician for outpatient treatment for any reason, age over 45 years, being diagnosed with copd, being a smoker or used to be a smoker once (\> 10 package years), to give consent for the use of their medical data. the patients that exhibit the following exclusion criteria will be excluded from the study: copd exacerbations still on-going or experienced in the last 3 months (exacerbation is defined as worsening of copd symptoms leading to antibiotic and/or short-term oral steroid treatment and/or hospitalization or admission to the emergency unit.); presence of lung cancer or an important respiratory disease such as bronchiectasis, pulmonary fibrosis, interstitial pulmonary disease, tuberculosis, sarcoidosis; participation in an interventional clinical trial at present and enrollment in this study once. in this study, patients will be recorded at their visit to the physician and there will be no follow-up thereafter.


Eligibility criteria:
inclusion criteria: * to apply to a physician for outpatient treatment for any reason; being diagnosed with copd * being a smoker or used to be a smoker once (\> 10 package years) * to give consent for the use of their medical data exclusion criteria: * copd exacerbations still on-going or experienced in the last 3 months * presence of lung cancer or an important respiratory disease such as bronchiectasis, pulmonary fibrosis, interstitial pulmonary disease, tuberculosis, sarcoidosis * participation in an interventional clinical trial at present and enrollment in this study once

Keywords: chronic obstructive pulmonary disease daily symptom variability effects of symptom on morning activities