Kornimate/medical-research-clean huggingface dataset:
the effects of a stainless steel suture mgh flexor tendon repair coupled with early aggressive range of motion rehabilitation: a randomized controlled trial

Conditions: Zone 2 Flexor Tendon Lacerations of the Hand

Summary: the investigators are comparing the combination of a stainless steel repair and aggressive early active range of motion rehabilitation protocol for flexor tendon lacerations in the hand with a current, accepted treatment offered at our institution. outcomes to be assessed will be time to return to work, joint range of motion in the injured fingers, and any potential complications that may arise (ex: surgical infections or repair rupture). all proposed treatments included in this study are currently being offered at our institution, but not in a randomized fashion.

this study will serve as a pilot-study for a future randomized controlled trial. adult patients with zone 2 flexor tendon lacerations of the hand (anatomically from the a1 pulley of the hand to the insertion of the flexor digitorum superficialis) who have presented to the emergency room acutely (within 1 week of injury) at the health sciences center in winnipeg will be asked for their participation in this study. consent will be obtained by a plastic surgery resident either in the emergency room or in the plastic surgency emergency decanting clinic. the investigators will include twenty-four patients in the study, randomized into one of two treatment groups (groups a and b) by block randomization. randomization will be done once patients agree to participate in the study. all patients will be booked for surgery on the emergency slate. each treatment group will be treated by a single surgeon who is an expert at treatment of these injuries. group a patients will have their laceration(s) repaired using a modified becker repair technique using stainless steel suture in the operating room, and then will proceed to undergo an aggressive early active range of motion rehabilitation administered by the hand therapists at hsc. group b patients will undergo a double-locking loop suture repair using polypropylene. they will then undergo a less aggressive active range of motion rehabilitation protocol which is currently offered to patients at our center. follow-up will occur in plastic surgery outpatient clinic at post-operative weeks 1, 2, 4, 6 and 12. follow-up with hand therapy will be at the discretion of the therapists. at each visit with hand therapy, joint range of motion will be assessed at the pip and dip joints in the affected fingers. final range of motion will be assessed using the strickland system for evaluating flexor tendon surgery outcomes, and will be done by a blinded hand therapist.

Eligibility criteria:
inclusion criteria: * adults * living in winnipeg, manitoba * zone ii flexor tendon lacerations in a single finger * able to consent to and comply with surgery exclusion criteria: * crush injuries * vascular injuries requiring re-vascularization * fractures * infection * prior hand injury requiring surgery
early ravulizumab treatment of anti- achr antibody-positive generalized myasthenia gravis

Conditions: Generalized Myasthenia Gravis; Anti-AChR Antibody Positive

Summary: the primary objective of the study is to evaluate the effectiveness of ravulizumab in improving mg-adl in an early-stage achr+ gmg population.


Eligibility criteria:
inclusion criteria: * diagnosis of mg confirmed by: * history of a positive serologic test for anti-achr antibodies, and * one of the following: * history of abnormal neuromuscular transmission test demonstrated by singlefibre electromyography or repetitive nerve stimulation * history of positive anticholinesterase test (e.g., edrophonium chloride test); or * patient demonstrated improvement in mg signs on oral cholinesterase inhibitors, as assessed by the treating physician * disease duration from mg onset ≤ 3 years before t-4 (enrolment); * mgfa class iib to iv; * patient eligible for ravulizumab treatment based on aifa reimbursement criteria * vaccination cycle for neisseria meningitidis completed at least two weeks before ravulizumab initiation or antibiotics chemoprophylaxis according to the smpc. exclusion criteria: * patient unable to understand and sign the informed consent * hypersensitivity to the active substance or to any of the excipients of the study product * patient for whom the study product is contraindicated according to smpc * previous treatment with c5 inhibitors * last rituximab infusion performed \< 6 months before t-4 (enrolment) * last infusion with fcrn blockers performed \< 3 months before t-4 (enrollment) * pregnant or lactating or planning a pregnancy during the study * patient who plan to relocate during the study * patient who are unsure of following the visit schedule * patient unable to complete questionnaires * previous or current participation to other interventional studies

Keywords: anti-achr antibody-positive generalized myasthenia gravis gmg ravulizumab
concordance between central blood pressure devices in nephrology patients

Conditions: Hypertension; Chronic Kidney Disease; Blood Pressure

Summary: the most accurate way to determine intra-aortic bp is to obtain invasive measures by vascular catheterization, which is not possible to perform routinely during the regular follow-up of patients. however, in recent years, devices used to estimate central bp have been designed and approved for clinical use. these devices can determine aortic bp in a non-invasive way using various techniques and algorithms and offer a high degree of precision when compared to invasive measurements of intraaortic bp. on the other hand, certain characteristics specific to the different devices mean that the central bp values obtained may not be interchangeable. it is therefore important to determine the degree of agreement of central bp values obtained using commercially available devices. this study aims to determine the degree of agreement between central bp measurements obtained using 4 devices commonly used to measure central blood pressure, i.e. mobil-o-graph ng (iem, germany), watchbp office (microlife, taiwan), oscar 2 with sphygmocor inside (suntech, usa) and bp+ (uscom, australia). these four devices record the shape of the pulsatile wave and then derive the central bp using an algorithm. the main differences between these devices lie in this algorithm, or "transfer function,", which is unique to each and the calibration used. all use a brachial cuff to capture the pulse waveform and can easily be used in clinical practice.


Eligibility criteria:
inclusion criteria: - age 18-80 years old exclusion criteria: * ongoing atrial fibrillation * arm circumference incompatible with the blood pressure cuffs for all devices (\ 50 cm) * incapacity to give consent

Keywords: central blood pressure
the effect of muscle strengthening associated with neuromuscular stimulus in patients with patellofemoral pain during negotiating stairs

Conditions: Patellofemoral Pain Syndrome

Summary: assess pain, function, hip and knee strength and kinematics of trunk and lower limbs during ascent and descent stairs after the addition of neuromuscular training to hip muscle strengthening.


Eligibility criteria:
inclusion criteria: * sedentary women, * previous knee pain last 3 months in at least two of the following activities: sitting for long periods, walk up or down stairs, squat, running and jumping exclusion criteria: * lower limb surgery, * patella displacement * knee instability * heart or locomotor disorders which might influence the evaluation
group-based cardiac telerehabilitation and its effectiveness

Conditions: Coronary Artery Disease

Summary: cardiovascular diseases (cvd) and coronary artery diseases (cad) are the most common cause of death worldwide. after an acute cardiac event, prevention of new cardiac events is essential and reduces suffering. group-based cardiac telerehabilitation (ctr) refers to the use of information and communication technologies for rehabilitation purposes in promoting cad patients´ health.

this study aims to assess the group-based cardiac telerehabilitation model and its effectiveness. the data is collected from two university hospitals in finland. patients with coronary heart disease two months after percutaneous coronary intervention (n=198) are invited to the study. all the participants are being treated in a healthcare unit that uses digital care pathways for coronary patients. patients can choose the usual care or group-based cardiac telerehabilitation as follow-up care. all the patients are invited to the study after the chosen follow-up care (telerehabilitation or usual care). patients will be allocated into two groups: the telerehabilitation group is the intervention group and the usual care group is the control group. quality of life, adherence to treatment, and lifestyle changes are measured at the baseline and 3, 6, and 12 after the intervention baseline.

Eligibility criteria:
inclusion criteria: * participants must have patients with coronary heart disease two months after percutaneous coronary intervention. * participants must have ≥18 years of age, and ≤100 years of age * participants are being treated in a healthcare unit that uses digital care pathways for coronary patients. exclusion criteria: * participants must not have coronary artery disease diagnosed. * participants have been in other operations than percutaneous coronary intervention.

Keywords: coronary artery disease cardiac telerehabilitation quality of life adherence to treatment lifestyle change
anlotinib and tqb2450 in advanced hepatocellular carcinoma after failure of prior immune checkpoint inhibitors

Conditions: Hepatocellular Carcinoma

Summary: this is an multi-center, single arm, exploratory study to evaluate the efficacy and safety of anlitinib combined with tqb2450 in patients with advanced hepatocellular carcinoma （hcc）who failed prior immune checkpoint inhibitor therapies.


Eligibility criteria:
inclusion criteria: * the participants must be required to sign an informed consent * hepatocellular carcinoma patients confirmed by pathological or cytological examination, or who meet the clinical diagnostic criteria of the "guidelines for the diagnosis and treatment of primary hepatocellular carcinoma" (2022) * at least one measurable lesion (recist 1.1) * chinese liver cancer staging (cnlc): cnlc-iia, iib, iiia, iiib (bclc-b and c) that are not suitable for local treatment (tace, haic, etc.) or that have progressed after local treatment * the previous treatment plan for patients before enrollment was a standard treatment plan containing immune checkpoint inhibitors, and patients with progression or intolerance were evaluated based on the recist v1.1 standard * child-pugh score, class a or better b * ecog performance status 0 or 1 * adequate organ function * life expectancy of at least 3 months exclusion criteria: * patients who have received local treatment (including tace, ablation, haic, radiotherapy) and are less than 1 month after enrollment * patients who have received ≥ 2 treatments with immune checkpoint inhibitor regimens * adverse events above level 1(nci-ctcae v5.0) caused by any previous treatment that have not returned to ≤ level 1 (excluding hair loss); patients with previous severe immune-related aes requiring permanent cessation of immunotherapy * pregnant or lactating wome
medication adherence in older adults with serious mental illness

Conditions: Schizophrenia; Bipolar Disorder; Depression

Summary: the goal of this pilot study is to learn about how well older people with serious mental illness (including schizophrenia, schizoaffective disorder, bipolar disorder, major depression) follow prescribed medication regimens, and to evaluate a manualized intervention designed to enhance medication management skills and adherence, the using medications effectively program. the following four hypotheses will be tested: 1. medication adherence will be associated with several variables including insight, memory, medication management skill, knowledge about medications, attitudes about medications. 2. people who receive the program will have better medication adherence compared to those who do not receive the program as measured by pill counts. 3. people who receive the program will develop better medication management skills compared to those who do not receive the program.

individuals who are already participating in a study of a combined skills training and health care management intervention for older people with serious mental illness are invited to join this study. half of the individuals have already been randomly assigned to receive the intervention and half have already been randomly assigned to continue receiving their usual care. the people receiving the intervention receive the skills training module, using medications effectively, in 8 group sessions over 8 weeks. the module includes information about common medications used for psychiatric and medical illnesses; training on using devices to help take medications properly; and instruction on strategies to help incorporate medication taking into a daily routine. a trained research assistant conducts pill counts and interview sessions with all participants after they sign an informed consent form, 8 weeks later, and 3 months after the second interview.

Eligibility criteria:
inclusion criteria: participation in rehabilitation and health care for older people with smi serious mental illness (schizophrenia, schizoaffective disorder, bipolar disorder, major depression) and functional impairment receiving mental health services for 3 months or more age 50 or older ability to provide informed consent or guardian consent - exclusion criteria: currently residing in an institution psychiatric illness caused by co-morbid medical condition dementia or score\<20 on mini mental state exam -

Keywords: serious mental illness medication adherence
the effect of yoga for stress among hiv patients in indonesia

Conditions: Human Immunodeficiency Virus

Summary: this study is aimed to evaluate the effects of yoga intervention versus usual care (control group) for reducing stress among people living with hiv in indonesia.

introduction: human immunodeficiency virus (hiv) continues to be a public health challenge for four decades after the disease appeared. stress is one of the most common mental health problems that occur among people living with hiv. yoga is increasingly popular as one of the complementary therapies in health care systems including in nursing. moreover, much evidence shows that yoga is a promising modality to be used to treat stress and to maintain the health and wellbeing of plwh. purpose: the primary objective in this study is to evaluate the effects of yoga intervention versus usual care (control group) for reducing stress among people living with hiv in indonesia. methods: this study will use a parallel group randomized controlled trial (rct) design, with single blinding, and repeated measures. sample will be divided into a yoga intervention group and a routine care group as the control group. in this study, the independent variable is defined as yoga intervention, and the dependent variable is stress. in total, participants who will participate is sixty-six, thirty-three participants in yoga group and thirty-three in control group. the generalized estimating equation will be performed for the data analysis.

Eligibility criteria:
inclusion criteria: participants are patients who * had been diagnosed with hiv. * were newly diagnosed or had taken arv medication for at least one month. * are age 18 years or older. * have access to a desktop, laptop, or smartphone on a regular basis. * have access to reliable internet. * are fluent in indonesian. * are willing to participate and sign the consent form. * are willing to be blood tested for cd4 counts or viral load at baseline and eight weeks after the intervention. exclusion criteria: patients who did not qualify to participate were: * those who reported performing yoga or other body-mind exercises at least one-month prior to the start of this study. * those who were not in physically fit condition * those who had been diagnosed with musculoskeletal problems, i.e., osteoporosis, osteoarthritis, bone injury, or spine problems. * those who have difficulty keeping their balance. * those who are currently pregnant, or plan to become pregnant during the trial.

Keywords: yoga stress, psychological human immunodeficiency virus
assessment of drug-drug interactions between masculinizing hormone therapy and antiretroviral agents concomitantly for pre-exposure prophylaxis among transgender men

Conditions: Drug Interaction

Summary: there are currently no published studies addressing drug-drug interactions (ddi) between masculinizing hormone therapy (mht) and pre-exposure prophylaxis (prep) among transgender men (tgm). this could lead to concerns and subsequent prioritizing mht over prep among tgm. because tenofovir alafenamide (taf) can achieve higher intracellular tenofovir diphosphate (tfv-dp) levels with lower tenofovir plasma concentrations, it is promising that both plasma tenofovir (tfv) and intracellular tfv-dp levels might not be significantly affected by mht. the current study aims to determine the pharmacokinetics (pk) ddi between mht and daily prep among tgm.


Eligibility criteria:
inclusion criteria: 1. thai nationality 2. age 18-40 years old 3. female-to-male transgender individual 4. hiv-negative 5. body mass index 18.5-24.9 kg/m2 6. negative urine pregnancy test 7. calculated creatinine clearance (crcl) ≥60 ml/min, as estimated by the cockcroft-gault equation 8. alanine aminotransferase (alt) ≤2.5 x uln 9. signed the informed consent form exclusion criteria: 1. known history of allergy to hormonal component to be used in the study 2. use of pre-exposure prophylaxis or post-exposure prophylaxis in the past 30 days 3. use of injectable mht in the past 3 months 4. evidence of current hepatitis b virus infection (hbv) - i.e. hepatitis b surface antigen \[hbsag\] positive 5. evidence of current hepatitis c virus infection (hcv) - i.e. hcv antibody positive 6. history of myocardial infarction or coronary artery disease 7. current use of any of the following: * anticonvulsants: carbamazepine, oxcarbazepine, phenytoin, or phenobarbital * herbs: gingko biloba, st john's wort or milk thistle * anti-infective agents: protease inhibitors, rifampicin or rifabutin 8. history of gastrointestinal tract surgery that alter gastrointestinal tract and/or drug absorption 9. alcohol or drug use that, in the opinion of the investigator, would interfere with completion of study procedures
exploration of cerebral pathophysiology during and after cabg using cpb

Conditions: Ischemic Heart Disease

Summary: purpose: the purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.

postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular. the reason for the cognitive decline is still not fully understood though many reasons have been proposed. inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.

Eligibility criteria:
inclusion criteria: * patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass exclusion criteria: * cerebrovascular disease

Keywords: coronary artery bypass grafting cardiopulmonary bypass cerebral oxidative stress cerebral inflammatory stress cerebral hemodynamics postoperative cognitive dysfunction
rectal indomethacin versus intraperitoneal lidocaine for analgesia after laparoscopic cholecystectomy

Conditions: Post-Operative Pain

Summary: hospitals, qena, egypt in period between may 2020 to may 2021.eighty patients was scheduled to elective laparoscopic cholecystectomy , divided into two groups randomly using closed envelop method. group ip lidocaine(40 patients ) received 200 ml saline containing 200 mg 2%lidocaine immediately after abdominal co2 insufflation( pneumoperitoneum) the surgeon sprayed the total solution on the upper surface of the liver under the right subdiaphragmatic space, left subdiaphragmatic space and around the cholecystectomy site , all patients were maintained in trendelenberg position. at the end of the laparoscopic procedure, group indomethacin (40 patients) recived two 100 mg indomethacin rectal suppositories 2 hours prior to surgery


Eligibility criteria:
inclusion criteria: * .asa physical status 1-2 patients. * 18-60 years old . exclusion criteria: * using or allergic to nonsteroidal anti inflammatory drugs (nsaids) or aspirin . * history of serious hepatic disease. * renal or gastrointestinal disease. * bleeding disorder. * body mass index bmi \<18 or ˃30 m2/kg. * history of abdominal surgery or chronic pain disorder other than gallbladder. * disease or allergy to lidocaine.
social anxiety virtual reality study

Conditions: Social Anxiety Disorder

Summary: this project aims to validate a virtual reality paradigm that assesses maladaptive avoidance behavior in social anxiety disorder. it also aims to generate a significant scientific advance by testing the hypothesis that maladaptive avoidance maintains anxiety through disruptions in safety learning.

although occasional mild social anxiety is a common human experience, social anxiety disorder has a devastating impact on patients' lives, leaving them vulnerable to medical, psychiatric, and socioeconomic complications. a key feature of social anxiety disorder is avoidance of social and/or performance situations in which judgment and evaluation from others might occur. reducing avoidance is therefore an important treatment goal. despite the importance of avoidance, however, it is very difficult to assess a patient's tendency to avoid. many prior assessments of avoidance measure adaptive (i.e., helpful) avoidance, in which an individual learns to avoid a truly noxious stimulus. however, anxiety disorders are characterized by maladaptive avoidance, in which a relatively safe stimulus is avoided resulting in interference with the individual's goals. in this study, the first aim is to validate a virtual reality paradigm to measure maladaptive avoidance behavior in adults with social anxiety disorder. the second aim is to test whether maladaptive avoidance behavior relates to safety learning (measured by a fear extinction task).

Eligibility criteria:
inclusion criteria: * age 18+ * primary diagnosis of social anxiety disorder * fluent spoken and written english * able to provide informed consent exclusion criteria: * history of manic episode, hypomanic episode, or psychosis * moderate or severe substance use disorder in the past 12 months * current major depressive episode greater than moderate severity (phq-9 score \>14) * high risk for suicide (\>8 on the mini suicidality section and/or clinician judgment that immediate medical attention is necessary) * general medical condition or impediment to vision, hearing, or motor function likely to interfere with assessments * benzodiazepine use in the past 2 weeks * cannabis use for anxiety management in the past 2 weeks