Kornimate/medical-research-clean huggingface dataset:
hyperbaric oxygen therapy for ulcerative colitis (hbot-uc)

Conditions: Ulcerative Colitis

Summary: chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (uc). hyperbaric oxygen therapy (hbot) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. two small prospective randomized controlled trials have demonstrated that the delivery of hbot to uc patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or colectomy. in this larger trial the study aims to confirm the treatment benefits of hbot for hospitalized uc patients and study the immune-microbe mechanisms underpinning treatment response.


Eligibility criteria:
inclusion criteria: * participants with known or newly diagnosed uc who require hospitalization for an acute moderate to severe flare * age 18-85 * able to fully participate in all aspects of the trial * consented and able to receive first hbot session within first 48 hours of initiation of intravenous steroids * agreement to not participate in another trial for the duration of the active intervention period exclusion criteria: * received hyperbaric oxygen therapy either as part of standard of care or through a clinical trial prior to enrollment * complication requiring urgent surgical intervention * requirement for new start of a biologic or small molecule during the hospitalization prior to randomization and/or anticipated requirement for rescue medical or surgical therapy within 48 hours of randomization * toxic megacolon * inability to receive intravenous steroids * historically failed or been exposed to 4 or more classes of advanced therapeutic options * known or suspected diagnosis of crohn's colitis, indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated with colitis, microscopic colitis or infectious colitis * received any investigational drug within 30 days * clinically significant cardiac, renal, neurological, endocrine, respiratory or hepatic impairment that increases the risk for hbot toxicity * women who are pregnant or nursing * unwillingness to complete course of hbot

Keywords: hyperbaric oxygen therapy hbot ulcerative colitis hyperbaric oxygen
a pilot study of migraine and appetite behaviour in children

Conditions: Migraine Disorders; Obesity

Summary: the purpose of this study is to determine whether there is an association between migraine in children and certain patterns of appetite or eating behaviour that may lead to later obesity.

migraine is a chronic neurological disorder characterized by recurrent episodes of headache and associated symptoms. the condition affects approximately 11% of the child population and it can impose considerable burdens on the sufferer either due to the headache itself, or associated co-morbidities such as psychological stress, obesity, sleep problems, etc. increasing attention is focussing on the shared genetic, environmental and neurobiological mechanisms of migraine co-morbidities to gain further insights into improving outcomes. we are interested in studying eating behaviours in children with migraine since there is evidence that altered patterns of eating behaviour (and underlying changes in appetite) are seen in migraineurs although not studied systematically. altered appetite and eating behaviours may be a mechanism for the emerging association between obesity (or degree of adiposity) and migraine severity, detected in both adult and paediatric studies to varying extents. studying the putative association between migraine, degree of adiposity and patterns of eating behaviour in children may help to tease out causal mechanisms, since both migraine and obesity often evolve over the course of childhood.

Eligibility criteria:
inclusion criteria: * children and adolescents between 5 years and 16 years of age. * clinical diagnosis of migraine (for cases). * controls are recruited from children referred with headache, who do not receive diagnosis of migraine. exclusion criteria: * adolescents 17 years or over. * secondary migraine-like disorder e.g., post-craniotomy headache.

Keywords: migraine children primary headache disorders appetite obesity feeding behavior
coronado (circulating tumour protein quantification capillary blood covid-19)

Conditions: Multiple Myeloma

Summary: the coronavirus (covid-19) pandemic has brought severe challenges for myeloma patients. myeloma patients are considered ultra-high risk for covid-19 and fall into the strictest group for shielding. when on treatment, but also during times of active surveillance, patients have to regularly and frequently leave shielding and visit the hospital for blood tests to monitor their disese. this is specifically for quantification of circulating tumour protein biomarker tests for paraprotein (pp) and/or serum free light chains (sflcs) by specialised biochemistry units. this research aims to evaluate the potential use of an at-home patient administered technique to sample blood. the purpose of the blood sampling technique is to monitor your disease status. we want to test if it is possible to monitor a patient's disease status using this alternative blood collection method when compared to monitoring disease status using the traditional blood collection methods (venous blood sampling). the new vams method is not intended to be used interchangeably or will not replace the current method. this study is to evaluate an alternative sample type that may be used to improve the patient pathway, especially during these uncertain times.


Eligibility criteria:
inclusion criteria: 1. a diagnosis of a b-cell dyscrasia 2. measurable disease by serum free light chain assay 3. signed informed consent exclusion criteria: 1. patients \<21 years of age 2. cognitive impairment 3. non-b cell dyscrasia patients
change in social media use and well-being among college students receiving a one-week exercise or mindfulness intervention

Conditions: Social Media Addiction; Depression, Anxiety; Well-Being, Psychological

Summary: the investigators will be randomizing 150 college student participants with high levels of social media use into either a 1) control condition (no intervention), a 2) mindfulness meditation cognitive intervention, or 3) a social media reduction + exercise replacement intervention. participants complete intervention activities daily for one week. the investigators will collect self-report and behavioral measures of social media use and related psychological constructs at three time points: baseline, immediately after the intervention period, and one-week after the intervention period.

the objective of this study is to test two cognitive and behavioral interventions designed to reduce social media use and psychological constructs related to social media use in a sample of university students. the first cognitive intervention is a mindfulness meditation exercise taken from the calm app centering around gratitude. each meditation takes approximately 12 minutes to complete and is to be done daily for one week. the second behavioral intervention is asking participants to reduce social media use for 30 minutes daily for one week and replacing that time with physical exercise of the participants' choosing. aim 1: compare psychological constructs related to mental health (well-being, stress, depression, anxiety, loneliness, social comparisons, etc.) before and after conducting two social media use interventions over a period of one week, compared to a control condition (no intervention). aim 2: compare self-reported and behavioral (smartphone screen shots of social media use screen time) measures of social media use before and after two social media use interventions over a period of over one week, compared to a control condition (no intervention). aim 3: examine mental health and social media use one week after the intervention period is complete (follow up), examining or testing whether effects last beyond the intervention period.

Eligibility criteria:
inclusion criteria: * the participant is 18 or older. * the participant must be a johns hopkins university student. * owning an iphone or android smartphone, with frequent use of social media use daily (\> 1 hour) * enabling and sharing screenshots of your smartphone use metrics, including number of last-week pickups, notifications received, and average screen time. * providing consent to participate. * only exercising 1 hour or less daily, on average. exclusion criteria: * younger than 18 * not a johns hopkins university student * doesn't own a smart phone * uses smartphone less than 1 hour daily * exercises more than 1 hour daily
impact of orthodontic treatment on the temporomandibular joints (tmj) assessed by modjaw

Conditions: Temporomandibular Joint Disorders

Summary: the aim of the study is to assess the correlation between orthodontic treatment and temporomandibular joint (tmj). for that, an evaluation with a virtual articulator (modjaw) is carried out before and after the treatment. the condylar course are compared. furthermore, the eventual tmj symptoms are also compared before and after.


Eligibility criteria:
inclusion criteria: * major patient (≥18 years) * first dentofacial orthopedic consultation at the dental clinic of montpellier * patient requiring multi-attachment orthodontic treatment (vestibular or lingual) for a duration ≤2 years * signed informed consent exclusion criteria: * syndromic patient * orthodontic treatment with aligners * general joint or bone pathology * patients with oral hygiene incompatible with orthodontic treatment

Keywords: temporomandibular joint orthodontic modjaw orthodontic braces
modified connective tissue graft wall with wing technique for posterior teeth

Conditions: Recession

Summary: the investigators reported here the application of usage modified connective tissue graft wall technique for posterior teeth. the treatment outcomes suggested the efficacy of the used technique in treating recession defects accompanied by infrabony defects in molars.

gingival recession is defined as the apical migration of the gingival margin leaving the root surface denuded. treatment of class iii and iv defects and achievement good of results seems to be quite difficult due to the advanced loss of the soft and hard tissues supporting the affected teeth. furthermore, partial to total loss of the interproximal papilla is one of the main challenges that contribute for achieving higher levels of esthetics especially in anterior zone. in such a case, conventional techniques of root coverage results usually in poor prognosis.

Eligibility criteria:
inclusion criteria: * recession defects in posterior teeth * vertical infrabony defects in relation to the same recession defect exclusion criteria: * smokers * suystemic diseases * pregnency and lactating mothers

Keywords: connective tissue wall technique modified connective tissue wall technique with a wing recession defects in posterior teeth recession defects with infrabony defects
facial nerve morbidity after superficial parotidectomy in the absence of nerve conductor

Conditions: Facial Nerve Injuries; Adenoma, Pleomorphic

Summary: in this single-centre, cross-sectional case series, the investigators aim to evaluate the incidence of facial nerve injury in patients undergoing superficial parotidectomy in the absence of nerve conductor. data to be collected retrospectively from a prospectively maintained database of consecutive patients, at the department of surgery, liaquat university of medical and health sciences jamshoro, pakistan. the sample size was calculated as 101.

in this single-centre, cross-sectional case series, the investigators aim to evaluate the incidence of facial nerve injury in partcipants undergoing superficial parotidectomy in the absence of nerve conductor. the institutional research ethics committee has approved the study. data to be collected retrospectively from a prospectively maintained database, at the department of surgery, liaquat university of medical and health sciences jamshoro, pakistan. the data period to be over a period of nine years that is from 1st january 2012 till august 2020. the sample size was calculated using the who sample size calculator and taking disease prevalence as 7.1 with ci 95%, which turned out to be 101. all the patients with pleomorphic adenoma irrespective of age and gender were included. to control any chance of bias, one of the members of researchers as part of the team who operated upon these patients. the primary outcome was the incidence of temporary or permanent facial nerve injury, while secondary outcomes were wound infection, seroma, hematoma, frey's syndrome, salivary fistula and disfigured scar. temporary facial nerve injury was defined as a feature of facial nerve palsy with full recovery to regular activity within six months. permanent facial nerve injury was defined as any facial nerve dysfunction lasting beyond six months of operation. the data was recorded on a predesigned performa, and patients' confidentiality was maintained assigning codes to each case known only to researchers. the data was calculated using spss version 23. values of mean and standard deviation were calculated for continuous variables, whereas frequencies were calculated for categorical data.

Eligibility criteria:
inclusion criteria: * all the patients with pleomorphic adenoma irrespective of age and gender were included exclusion criteria: * patients with recurrent disease or unwilling for participation were excluded

Keywords: superficial parotidectomy facial nerve injuries adenoma, pleomorphic
aneurx post market study in the treatment of aaa

Conditions: Abdominal Aneurysm

Summary: the aorta is a large blood vessel that carries blood away from the heart to the organs in the rest of the body. an aneurysm is a weakening in the artery wall that will become a bulge in the aorta. if left untreated, this bulge may continue to grow larger and may rupture (break open) with fatal consequences. abdominal aortic aneurysm (aaa) is a life-threatening lesion that has been treated in recent year via endovascular repair. the purpose of this study is to monitor the long term performance of the aneurx stent graft systems.


Eligibility criteria:
inclusion criteria: * patients implanted with an aneurx stent graft per instructions for use * patients must provide written informed consent and agree to be accessible for follow-up at the study center.

Keywords: abdominal aneurysm endovascular aortic repair (evar) endovascular stent graft endograft
non-invasive neuromodulation nesa application in the rehabilitation of stroke sequelae

Conditions: Stroke

Summary: to evaluate whether nesa microcurrents can be used as an effective treatment for various sequelae present in stroke patients, specifically in the treatment of spasticity, balance, pain; and whether it affects quality of life, performance of activities of daily living and quality of sleep.

pilot study following a randomized controlled trial design, designed to study the feasibility of a study with a larger sample size. intervention of 30 stroke participants with an evolution between 6 months and 4 years since the stroke, who are able to stand upright. these participants will be recruited voluntarily through a campaign in social networks and with the collaboration of local associations and institutions. once the inclusion and exclusion criteria have been reviewed, they will be randomly assigned to an intervention group and a placebo group. a double-blind recruitment system will be followed in which the physiotherapist and patients will not know whether they are receiving real or simulated stimulation, for this purpose two nesa xsignal® devices will be used in double-blind mode. treatment of 20 sessions per patient, of 1 hour duration each, with the nesa x-signal device.

Eligibility criteria:
inclusion criteria: * people who have suffered a stroke with an evolution between 6 months and 6 years. * optimal cognitive capacity and mentally competent to participate in the study and complete the required questionnaires. * people able of standing upright, including those who need technical aids. exclusion criteria: * present some of the contraindications for a treatment with nesa xsignal®: pacemakers, internal bleeding, not to apply electrodes on skin in bad condition, with ulcerations or wounds, acute febrile processes, acute thrombophlebitis and/or phobia to electricity. * not having signed the informed consent form. * presenting any additional injury or pathology during the study. * not having the optimal cognitive capacities for understanding and participating in the study.

Keywords: physical therapy modality electric stimulation therapy
risk of gastric reflux during tulip vs gma(glottis mask airway) airway

Conditions: Anesthesia

Summary: glottis mask airway (gma) is supraglottic airway device and is frequently used in patients undergoing general anesthesia. however, gastroesophageal reflux remains a risk during ventilation through supraglottic airway devices. the classical shaped gma and tulip shaped gma differ in the shape of their tips. and theoretically the tulip shaped tip fits the larynx better. this study aims to compare the incidence of gastroesophageal reflux during ventilation through classical shaped vs tulip shaped glottis mask airway.


Eligibility criteria:
inclusion criteria: * age≥18 years old * scheduled for surgery under general anesthesia with laryngeal mask airway exclusion criteria: * american society of anesthesiologists status score higher than 3 * morbid obesity (body mass index higher than 40 kg/m2) * with high risk of gastroesophageal reflux * with risk of difficult airway * with airway disease

Keywords: general anesthesia glottis mask airway tulip shaped tip gastroesophageal reflux
the addition of whole grains to the diets of middle-school children

Conditions: Healthy

Summary: the dietary guidelines for americans recommend that children and adolescents "consume whole-grain products often; at least half the grains should be whole grains." few, if any studies, examine the benefit of whole grains on the health of adolescents. the purpose of this study is to determine if adolescents eating diets rich in whole grains vs. diets rich in refined grains (i.e., a typical diet) have improved markers of digestive and immune health.

middle-school students will be recruited and randomized to receive \>/=80 g of whole grains (\>/=5 servings) or similar foods made with refined grains each day for six weeks. based on treatment group, subjects will be provided either whole grain or refined grain foods and snacks. they will be instructed on how to use these foods to replace other foods already contained in the diet. stool, blood, and saliva samples will be obtained at baseline and at study end to examine the microbiota and markers of digestive and immune health. daily records will be maintained by the students to assess bowel habits and compliance. it is anticipated that whole grains will increase stool bulk resulting in increased stool frequency and softer stools. additionally, fermentation of the fiber within the colon will alter the microbiota profile. because the majority of the immune system resides within the gastrointestinal tract, improved balance of the intestinal microbiota may prime the immune system thus contributing to improved immune defense.

Eligibility criteria:
inclusion criteria: * middle-school student at westwood middle school, gainesville, fl * parental/guardian consent * willing to eat three different study foods each day for six weeks * willing to provide two blood samples and two saliva samples over the course of the study exclusion criteria: * taking medications for constipation or diarrhea * antibiotic therapy within the past four weeks prior to randomization * takes probiotics or consumes greater than three servings of yogurt per week * has any diseases or illnesses such as gastrointestinal disease (gastric ulcers, crohn's, ulcerative colitis, etc.), other chronic diseases (diabetes, kidney disease, etc.) or immune-modulating diseases (hiv, aids, autoimmune, hepatitis, cancer, etc.) * has any food allergies (wheat, soy, egg, milk, gluten, nuts, or any other food or food ingredient)

Keywords: adolescent whole grain digestive health dietary fiber grain microbiota inflammation mucosal immunity
clinical assessment of 3 differant obturation sealers on postoprative pain and swelling

Conditions: Necrotic Pulp; Single Root Teeth

Summary: aim of the study will be conducted to compare the effect of mta fill apex sealer and endo sequence bioceramic sealer in obturation on the intenisty of postoperative pain and the incidence of post operative swelling in patient with necrotic teeth .


Eligibility criteria:
inclusion criteria: * patients requiring root canal treatment of single canal necrotic teeth. * patient from 18 to 60 years old * patients with asymptomatic apical periodontitis. * teeth presenting with no clinical symptoms and with a periapical score from 2 to 4 according to orstavik et al exclusion criteria: * teeth with incompletely formed apex * teeth requiring retreatment * patients having complicating systemic disease such as diabetes, malignancy, pregnancy, central nervous system disorders, cardiovascular system disorders, respiratory disorders, asthma patients, psychiatric disorders, immunocompromised patients * patients taking anti-inflammatory or antibiotics * patients giving history of analgesic or antibiotic intake 1 week before treatment * patients below 18 years of age * patients above 65 years of age * patients having history of peptic ulcer or gastrointestinal bleeding * teeth affected with periodontal disease
cardiovascular health in postpartum women diagnosed with excessive gestational weight gain

Conditions: Pregnancy; Weight Gain

Summary: the investigators will test the efficacy of a tailored behavioral lifestyle modification program to support cardiovascular health in postpartum women with excessive gestational weight gain. this program will include a mobile health texting component postpartum to support changes in nutrition and physical activity. the investigators will randomize women into either the control arm (usual care) or the intervention (usual care + mobile health program postpartum). the women will be recruited during their 3rd trimester once they have been identified as gaining too much weight according to the 2009 iom guidelines during pregnancy.


Eligibility criteria:
inclusion criteria: * pregnant woman diagnosed with excessive gestational weight at 24 weeks gestation or later * age 18 years or older * english-speaking, and willing and able to participate in the proposed intervention. exclusion criteria: * inability to provide informed consent and/or an inability to speak, read, or understand english * primary residence is outside of the immediate catchment area of 10 miles * physical or mental challenges that precludes them from exercising or returning for scheduled study follow ups * concurrent enrollment in another behavior modification program

Keywords: pregnancy obesity/overweight postpartum mobile health cardiovascular disease