Kornimate/medical-research-clean huggingface dataset:
a study of donanemab (ly3002813) in participants with early symptomatic alzheimer's disease (trailblazer-alz 5)

Conditions: Alzheimer Disease; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Summary: the reason for this study is to assess the safety and efficacy of donanemab in participants with early alzheimer's disease. the study duration including screening and follow-up is up to 93 weeks.

trailblazer-alz 5 is a phase 3, double-blind, placebo-controlled study to evaluate the safety and efficacy of donanemab in participants with early symptomatic ad (prodromal ad and mild dementia due to ad) and the presence of ad pathology.

Eligibility criteria:
inclusion criteria: * gradual and progressive change in memory function reported by the participant or informant for ≥6 months. * a mmse score of 20 to 28 (inclusive) at screening visit. * meet amyloid scan (central read) criteria. * have a study partner who will provide written informed consent to participate, is in frequent contact with the participant (defined as at least 10 hours per week), and will accompany the participant to the study or be available by telephone at designated times. * a second study partner may serve as backup. the study partner(s) is/are required to accompany the participant for signing consent. the study partner must be present on all days the cognitive and functional scales are administered. * if a participant has a second study partner, it is preferred that 1 study partner be primarily responsible for the cdr and the adcs-adl assessments. * days requiring the following assessments and scales must have a study partner available by telephone if not accompanying participant for the following assessments * aes and concomitant medications * cdr, and * adcs-adl * stable concomitant symptomatic ad medications and other medications that may impact cognition for at least approximately 30 days prior to randomization. exclusion criteria: * has significant neurological disease affecting the central nervous system other than ad, that may affect cognition or ability to complete the study, including but not limited to, other dementias, serious infection of the brain, parkinson's disease, multiple concussions, or epilepsy or recurrent seizures (except febrile childhood seizures). * has current serious or unstable illnesses including cardiovascular, hepatic, renal, gastroenterologic, respiratory, endocrinologic, neurologic (other than ad), psychiatric, immunologic, or hematologic disease and other conditions that, in the investigator's opinion, could interfere with the analyses in this study; or has a life expectancy of \<24 months. * history of cancer within the last 5 years, except of non-metastatic basal and/or squamous cell carcinoma of the skin, in situ cervical cancer, nonprogressive prostate cancer, or other cancers with low risk of recurrence or spread. * contraindication to mri or pet scans.

Keywords: alzheimer's dementia cognitive impairment amyloid plaque
serum galectin-3 as a marker of human papillomavirus infection

Conditions: Human Papillomavirus Infection

Summary: this study aimed to assess the serum galectin-3 levels in patients with warts both before and after cryotherapy and to investigate its potential contribution to the pathogenesis of human papillomavirus infection.

galectin-3 regulates many functions at the cellular level such as cell attachment, proliferation, and apoptosis. numerous viral illnesses, including human papillomavirus infection, were reported to have elevated serum levels of galectin-3. . methods: fifty patients suffering from warts, and fifty healthy controls were included in this study. enzyme-linked immunosorbent assay was used to measure serum levels of galectin-3 both before and 2 weeks after the last cryotherapy session.

Eligibility criteria:
inclusion criteria: 1. patients with non-genital warts. 2. age of patients: from 18 to 60 years. exclusion criteria: 1. patients with genital and mucosal warts. 2. pregnancy and breastfeeding. 3. patients who received any wart treatment during the last month before enrollment in the study.

Keywords: galectin-3 human papillomavirus warts cryotherapy
knowledge, and practice of helicobacter pylori infection

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori infection is very common in our community however, it may be misdiagnosed and treated from the start until the patient present with complications. therefore, it is essential that primary care physicians have the appropriate knowledge for making adequate decisions and preventing incorrect practices that result in elevated costs and absolutely no health benefits for the population. so this study aims to evaluate the knowledge and practice of primary healthcare physicians at sohag health care units concerning h. pylori infection.

the most common cause of chronic gastritis is helicobacter pylori, which can also cause serious gastroduodenal diseases in some patients. these include gastric cancer, gastric mucosa-associated lymphoid tissue (malt) lymphoma, and gastric and duodenal peptic ulcer disease (pud). strong correlations have been shown between h. pylori and a number of extra-gastric illnesses, including vitamin b12 deficiency, idiopathic thrombocytopenic purpura, and unexplained iron-deficiency anemia. identifying and eliminating h. pylori in people suffering from these conditions is also advised. furthermore, neurological disorders, cardiovascular disorders, hepatobiliary disorders and autoimmune disorders may be associated with h. pylori infection. age, ethnicity, degree of hygiene, and social and economic circumstances are risk factors for h. pylori infection an elevated prevalence of gastrointestinal diseases or symptoms (for example, dyspeptic symptoms) in populations where h. pylori infection is high, implies that a large number of subjects receive primary health care.therefore, it is essential that primary care physicians have the appropriate knowledge for making adequate decisions and preventing incorrect practices that result in elevated costs and absolutely no health benefits for the population. since day-to-day clinical practice demonstrates that many healthcare disciplines surprisingly deal with h. pylori infection in the absence of local guidelines on this matter, there has been no study conducted in sohag governate evaluated knowledge, practice and attitude about h. pylori among healthcare physicians as of the time i conducted this survey.

Eligibility criteria:
inclusion criteria: * physicians at primary healthcare units in sohag governorate exclusion criteria: * nonmedical personnel * git specialists * physicians at secondary or tertiary healthcare centers
characterization of smoking habits patterns in medical doctors of a central hospital in portugal - what has changed after 15 years? a comparative cross-sectional study

Conditions: Smoking Cessation; Tobacco Dependence

Summary: abstract: tobacco dependence remains one of the primary health care concerns worldwide. attitude of healthcare professionals towards smoking is crucial for any long-term prevention and smoking cessation program. objectives: analyze smoking habits of medical doctors from a central hospital in lisbon (2014), comparing results between medical versus surgical specialities. results were compared with those obtained in 1999. design and setting: a voluntary and anonymous questionnaire was distributed to all physicians for a period of 4 months. the questions included sociodemographic data, smoking habits characterization, attitudes towards smoking, importance attribute to smoking cessation programme in the hospital and knowledge of the 2008 country law. participants: all medical doctors working in the central hospital studied between 1/1/2014 and 30/6/2014 outcome measures: the primary outcome measure was to characterize the smoking habits of medical doctors. secondary outcomes included comparison of results between surgical and medical groups and with those obtain in a similar study in 1999.


Eligibility criteria:
inclusion criteria: * all medical doctors working in the central hospital studied between 1/1/2014 and 30/6/2014 exclusion criteria: * not a medical doctor
a brief intervention for cannabis use

Conditions: Cannabis Use Disorder

Summary: the purpose of this study is to compare two brief interventions targeting potentially problematic cannabis use in emerging adults (ages 18-25). brief interventions are two 40-50 minute sessions separated by 1 week. eligible emerging adults will complete a detailed cannabis assessment (biological and self-report), followed by one of the two brief interventions, and three follow-up assessments: one immediately after the second session and at 1- and 3-months post-intervention. assignment to the brief intervention is random. salivary samples will be collected at baseline, post-intervention, and both follow-ups, for a total of 4 samples, to be tested for tetrahydrocannabinol (thc) and cannabidiol (cbd).

cannabis is the most widely used federally illicit substance among emerging adults (age 18-25) in the u.s., and frequent cannabis use is associated with myriad long-term health, social, and academic/occupational consequences. despite this, rates of perceived risk of daily/regular cannabis use have steadily declined over the past two decades, and this is associated with increased frequency of use, a risk for for cannabis use disorder (cud). brief interventions (bis) are among the most frequently used approaches for addressing problematic or potentially problematic substance use in non-treatment-seeking adolescents and young adults. although several cannabis brief interventions have been developed and tested to date, meta-analyses indicate that the efficacy of these interventions for emerging adults is mixed and the quality of studies is low, suggesting that novel approaches and rigorous methodology are necessary to improve efficacy. the current study will evaluate the feasibility, acceptability, and preliminary efficacy of a novel cannabis bi for emerging adults who frequently use cannabis.

Eligibility criteria:
inclusion criteria: * ages 18-25 * self-report report cannabis use on at least 20 days of the past 30 days. * completion of an intake visit (pro #94743) * submit a positive urine cannabinoid test during the intake visit exclusion criteria: * currently engaged in substance use treatment for any type of substance use or currently treatment seeking * history of substance use treatment for any type of substance * severe alcohol use disorder or presence of any substance use disorder (sud) requiring a higher level of care * significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation * significant risk of suicide or homicide

Keywords: early intervention emerging adults
impact of aerobic exercise training on sympathetic vasoconstriction and vascular function in essential hypertension

Conditions: Hypertension,Essential

Summary: sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. the main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. a secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,


Eligibility criteria:
inclusion criteria: * sedentary men and women age 35 - 65 years * resting blood pressure \>140/90 mmhg or resting blood pressure \<140/90 mmhg * essential hypertension * non or exclusively antihypertensive medication exclusion criteria: * hypertensive condition other than essential hypertension * other chronical diseases * smoking * excess alcohol intake or drug abuse

Keywords: pannexin-1 channel
music during dental children care under meopa

Conditions: Dental Diseases

Summary: in france, the improvement of dental care for children in general and even more so for children with special needs is a real public health issue. indeed, children under 6 years of age, children with a fear that is difficult to control and who have failed to receive care, or children with disabilities, have difficulties in receiving care. because of their medical wandering before effective therapeutic care, they are up to 4 times more likely to have a very degraded oral health condition involving avulsions rather than conservative care. moreover, these complex situations often lead to the indication of dental care under conscious sedation with an equimolar mixture of oxygen and nitrous oxide (meopa) or even under general anesthesia (ga); hospital sedation by administration of midazolam is exceptionally proposed. as access to ga care is largely insufficient, solutions likely to improve the success rate of care and anxiolysis provided by meopa associated with cognitive-behavioral management must be considered. among these, music has been shown to have variable neurophysiological effects (action on cardiac and respiratory rhythms and on blood pressure), depending on the style of music used. during dental care, a biological and psychological impact on emotion has been highlighted, although the few studies carried out in children in this particular context are not at a high level of proof. in children with special needs, the addition of music to meopa could therefore increase relaxation or distraction during dental care and improve the success rate of sedation by meopa. validation of this hypothesis would limit the redirection of the young patient under ga and prevent the loss of opportunity associated with a further delay in care of several months.


Eligibility criteria:
inclusion criteria: * children aged 4 to 12 years referred for dental care under sedation in one of the four hu dental services * children requiring at least two sessions of the same type and duration * consent of the holders of parental authority, consent of the children * health coverage for the child (social security affiliation) * child and parents are french speaking and able to communicate with the medical team exclusion criteria: * contraindications to the use of meopa * nasal breathing disorders such as a flu syndrome ("blocked nose" not allowing nasal ventilation) * hearing impaired children * patients with complications during inhalation (especially headaches)
sg healthcare and assistive robotics programme (sharp) - proof of concept study

Conditions: Stroke; Joint Replacement Surgery; Acquired Brain Injury; Spinal Cord Injuries; Traumatic Brain Injury With Loss of Consciousness

Summary: robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries. these applications could provide direct benefits to patients in the clinical rehabilitation field. in this study, the feasibility of 2 care robot prototypes in facilitating dependent transfers and assisting patient mobility in their daily living activities will be studied.

an exploratory proof of concept study involving the development and usability of 2 care robot prototypes will be validated in a hospital environment, in a broad range of patients. the findings from this study will then be used to further refine and develop the robot prototypes for future deployment in other hospitals, nursing homes and homes.

Eligibility criteria:
inclusion criteria: * aged 21-85 years * primary reason for admission is in /outpatient rehabilitation. * admission (within 72 hours) functional independence measure (fim)(transfer/walk) score of 1-5 or modified barthel index score (transfer/walk) of 0, 5 or 10. * activity tolerance for ambulant patients of \>30 minutes. * patient able to sign own consent and understand simple instructions. exclusion criteria: * pregnancy or lactation. * medical instability, uncontrolled sepsis, orthostatic hypotension, contraindications to verticalization. (unstable spinal fractures, severe pain) weight-bearing on either limb), abdominal aneurysms * patients with behavioural problems (agitation, untreated depression, psychiatric problems) * skin conditions which could be worsen by the abdominal, trunk, knee and calf cuffs of straps of the care robots. * patients who are unable to sign own consent or understand simple instructions.

Keywords: assistive robots
three-month clinical evaluation of silicone hydrogel definitive 65 contact lenses

Conditions: Ametropia

Summary: comparison of different contact lens materials.

this will be a 3-month, open-label, bilateral, parallel-group, randomised, daily wear study. two-thirds of the subjects will wear the test lenses in both eyes, and one-third will wear the control lenses in both eyes.

Eligibility criteria:
inclusion criteria: * willing and able to sign the informed consent form * ages 18 years or older * subjects must have owned spectacles or contact lenses prior to enrolment for this trial * spherical power between -10.00 d and +10.00 d (at vertex distance 0 mm) * astigmatic power equal to or less than 0.75 d exclusion criteria: * eye injury or surgery within 3 months immediately prior to enrolment for this trial * pre-existing ocular irritation that would preclude contact lens fitting * currently enrolled in an ophthalmic clinical trial * evidence of systemic or ocular abnormality, infection or disease which is likely to affect successful wear of contact lenses use of as determined by the investigator * any use of medications for which contact lens wear could be contradicted, as determined by the investigator * current extended-wear users (sleep-in overnight) * current monovision leans wearers * pregnant women and nursing mothers * best-corrected visual acuity worse than 6/9 (logmar: +0.20; snellen decimal: 0.63)
il-32 isoforms levels in gcf and plasma of the patients with periodontitis

Conditions: Periodontitis

Summary: interleukin (il)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. the aim of this study was to investigate the levels of il-32α, il-32β, il-32γ, il-32δ isoforms in gingival crevicular fluid (gcf) and plasma before and after nonsurgical periodontal treatment in patients with periodontitis (p).twenty-seven p and 27 periodontally healthy controls (c) were recruited in this study. periodontitis patients were performed nonsurgical periodontal treatment. gcf and plasma sampling and clinical periodontal parameters were evaluated before and 1 month after treatment. enzyme-linked immunosorbent assay was used to analyze the levels of il-32α, il-32β, il-32γ, il-32δ isoforms in gcf and plasma samples.


Eligibility criteria:
inclusion criteria: * have at least 20 natural teeth, excluding third molars. * periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (pd) ≥ 5 mm and clinical attachment level (cal) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting \>30% of the teeth, as detected on clinical and radiographical examinations. * periodontally healthy control group had no sign of gingival inflammation, no pd \> 3mm and no evidence of attachment or bone loss exclusion criteria: * history of systemic disease. * regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study. * periodontal treatment during last 6 months that could affect periodontal status. * smoking. * history of radiotherapy or chemotherapy. * current pregnancy, lactation or menopause.
exercise training and cardiovascular function in obesity and in type 2 diabetes

Conditions: Type 2 Diabetes; Obesity

Summary: obesity and diabetes increase cardiovascular risk by complex and incompletely known mechanisms. the aims of this study are : 1. to compare cardiac and vascular functions at rest and during exercise in 4 groups of age-matched men, without cardiovascular diseases but exhibiting increasing cardiovascular risk: trained and untrained healthy volunteers, obese and type 2 diabetic subjects 2. to test the effects of a 8-weeks long individualized training program on these functions in obese subjects and in diabetics patients.

obesity, especially in its truncal distribution, and type 2 diabetes, increase cardiovascular risk. mechanisms underlaying both early preclinical, and clinical cardiovascular complications are complex and still incompletely clarified. however, relationship between central, i.e. cardiac, and peripheral, i.e. vascular dysfunctions remains unclear, as well as their respective role in reduced exercise tolerance in these populations. moreover, exercise training can improve both metabolic status and cardiovascular risk, and thus, has proven useful in management and prevention of chronic metabolic diseases. nevertheless, respective effects of training on cardiac and vascular functions, and on their interaction at rest, but also during exercise, need to be clarified. therefore, the aims of this study are : 1. to compare cardiac and vascular functions at rest and during a local maximal leg exercise in 4 groups of age-matched men, without cardiovascular diseases but exhibiting increasing cardiovascular risk: trained and untrained healthy volunteers, obese and type 2 diabetic subjects 2. to test the effects of a 8-weeks long individualized training program on these functions in obese subjects and in diabetics patients.

Eligibility criteria:
inclusion criteria: * non-diabetic obese subjects and type 2 diabetic subjects exclusion criteria: * smoking * known peripheral artery insufficiency * heart failure * uncontrolled hypertension * thyroid disease * insulin dependent diabetes * for diabetics subjects : hba1c \> 10 %

Keywords: vascular function cardiac function individualized training ultrasonography body composition