Kornimate/medical-research-clean huggingface dataset:
perioperative aspirin usage survey

Conditions: Surgery; Cardiovascular Disease

Summary: this is a survey of members of the american college of surgeons (acs), to describe and explore current patterns of their decisions about withholding or continuation for patients taking aspirin (asa) in the perioperative period. secondarily, the survey will also explore surgeons' knowledge about the risks and benefits attending this decision, and about national organizations' recommendations.

an announcement of the survey and invitation to participate will be posted in the "acs surgery news" newsletter published by the american college of surgeons. surgeons of all specialties will be invited to participate. no identifiers will be maintained with survey responses. in addition to the substantive questions below, typical demographic data will be obtained including participants' duration of practice, specialty, gender, state, etc. the survey will include questions intended to characterize current practice surrounding the decision to continue or withhold aspirin in the perioperative period. other questions will focus on surgeons' knowledge of national medical/surgical organizations that have published guidelines on the perioperative use of aspirin. finally, other survey questions will characterize surgeons' knowledge of the platelet rebound effect.

Eligibility criteria:
inclusion criteria: * members of the american college of surgeons exclusion criteria: * none
clinical study on the treatment of mafld with ganzhixiao capsules

Conditions: MAFLD

Summary: this trial is expected to enroll 138 mafld patients in one clinical center, who will be randomly divided into a placebo group and a ganzhixiao capsule group in a 1:1 ratio. there will be 69 patients in the ganzhixiao group and 69 patients in the placebo group. administer ganzhixiao capsules or mimetics separately, intervene for 16 weeks, and compare the liver fat content、 alt、 changes in indicators such as cytokeratin 18 fragment, fib-4 score, and lsm score. among them, mri-pdff is the main efficacy evaluation index to evaluate the clinical efficacy of ganzhixiao capsules in the treatment of mafld.

all participants in the trial were required to have a low-fat diet and engage in aerobic exercise for 150 minutes per week.

Eligibility criteria:
inclusion criteria: * age between 18 and 70 years old, with a body mass index (bmi) of at least 24kg/m2; * diagnosis of nafld determined by imaging \[ultrasound, computed tomography or magnetic resonance imaging (mri-pdff)\] or liver biopsy, showing mafld or simple steatosis within the last 24 months prior to screening; * mafld patients conform to the damp heat syndrome type; ④ voluntary signing of informed consent form exclusion criteria: * blood biochemical indicators alt, ast, bun are greater than 1.5 times the upper limit of normal values, cr is greater than the upper limit of normal values, egfr\<60ml/min/1.73m2; * alcoholic fatty liver, other chronic liver diseases, cirrhosis, liver malignant tumors, etc.; * type 2 diabetes and pancreatic diseases; * taking some hypoglycemic, lipid-lowering, liver protective drugs or high-dose vitamin e that may affect the efficacy judgment in the past three months; * patients with severe infections, cardiovascular, respiratory, renal, hematological, rheumatic connective tissue disease, neuropsychiatric, and non liver malignant tumors; * pregnant or lactating women; * those who require long-term hormone therapy; * researchers anticipate poor compliance or inability to cooperate; * there are contraindications for mri examination, including pacemakers or cochlear implants, postoperative artificial valve replacement, presence of ferromagnetic vascular clips in the body, metal foreign bodies in the eyeball, insulin pumps, ferromagnetic objects in the scanning field, metal dentures, intrauterine devices, and patients with claustrophobia.
the influence of pneumoperitoneum on minimal invasive cardiac output measurements

Conditions: Pneumoperitoneum

Summary: perioperative goal directed fluid therapy may reduce complication rate after surgery. minimal invasive cardiac output monitoring is a key method to guide fluid therapy. more operations are being performed by keyhole surgery (laparoscopy). for laparoscopy, the abdomen is filled with carbon dioxide. increased pressure in the abdomen may influence minimal cardiac output monitoring, therefore minimal cardiac output monitoring is not recommended during laparoscopy. this study aims to validate minimal cardiac output monitoring during laparoscopy and therefore facilitate for goal directed fluid therapy.


Eligibility criteria:
inclusion criteria: * all patients \>18 years scheduled for robot-assisted prostatectomy * able to give informed consent exclusion criteria: * patient with atrial fibrillation or other non-regular rhythm. * severe aorta/mitral stenosis * not able to give informed consent

Keywords: difference of measurements before and after
evaluation of a new blood pressure measuring device.

Conditions: Hypertension

Summary: * a disposable blood pressure measuring device will be tested and compared to a standard mercury sphygmomanometer. * up to 100 subjects with various levels of blood pressure values will be tested.

the study will comprise 85 to 100 subjects with blood pressure values ranging between 90 and 170mmhg -systolic and 65-95 -diastolic. * three sets of measurements will be performed on each subject. the measurement with the tested device placed between twh determinations with a mercury sphygmomanometer. * each measurement will be performed simultaneously by two examiners specially trained. * informed consent will be obtained from all participants. * the results will be evaluated by a standard statistical plan ansi/aami sp-10 2002.

Eligibility criteria:
inclusion criteria: * male or female, age 18 years or above * signed written informed consent exclusion criteria: * a history of cardiac arrythmia * wrist circumference smaller than 13cm or larger than 19.5cm * documented peripheral vascular disease * damage or injury to the left wrist * participation in any other clinical study * any acute coronary of cardiovascular illness

Keywords: hypertension hypotension
premature rupture of mambrane and unfavourable cervix

Conditions: Cervix; Insufficient Dilatation in Labor

Summary: the paucity of published data concerning the issue of mechanical labor induction in the setting of term prom has led us to undertake the present clinical trial. this study is designed to compare the efficacy and safety of the standard oxytocin induction protocol with the double-balloon catheter device with concurrent oxytocin administration in patients with term prom and unfavorable cervical conditions.

this will be a prospective randomised trial. two hundred pregnant women with term prom and an unfavourable cervix (bishop score ≤ 4) are expected to be entered into the study (see statistical analysis below). all eligible women will be presented with the study protocol by a study coordinator. women interested in participating will read and sign the informed consent. subsequently, the following screening medical procedures will be completed: medical and gynecological history, physical and vaginal examination, ultrasonography to: (i) confirm fetal vertex presentation, (ii) exclude placenta previa and (iii) assess cervical length and posterior cervical angle. (iv) asses bio-physical profile score a non-stress test will be performed in order to monitor: 1. the fetal heart pattern for the presence or absence of decelerations and 2. the presence of uterine contractions. all women will undergo a pelvic examination by a staff member to obtain an initial bishop score. if the patient will be determined eligible for study entry, and following the informed consent, randomisation into the following groups will take place: group 1: oxytocin infusion alone (standard protocol). group 2: insertion of the double balloon device and concurrent oxytocin administration. group 3: expectant management

Eligibility criteria:
inclusion criteria: 1. diagnosed to be pregnant with prom at \> 34 week 2. found to have a bishop score of 4 points or less. 3. diagnosed as having a singleto 4. willingness to comply with the protocol for the duration of the study. 5. have signed an informed consent. exclusion criteria: 1. any contraindication for a vaginal deliver 2. regular uterine contractn 3. evidence of chorio-amonitis 4. previous cesarean section or presence of any uterine scar. 5. suspected placental abruption or presence of a significant hemorrhage. 6. non-reassuring fetal statu
comparison of two miniscrew anchored maxillary protraction protocols

Conditions: Malocclusion, Angle Class III; Crossbite (Anterior) (Posterior)

Summary: this study evaluates the dentoskeletal effects produced by two maxillary protraction protocols in adolescent patients. half of participants will be treated with a tooth-borne and tooth-bone-borne expanders as anchorage in the maxillary arch. miniscrews will be used as anchorage in the mandibular arch for both groups.

class iii malocclusion treatment in growing patients is challenging. a new treatment for maxillary protraction using skeletal anchorage reported an efficient maxillary protraction in the late mixed dentition an early permanent dentition. therefore, the aim of this study is to compare the dentoskeletal effects produced by two maxillary protraction protocols anchored on miniscrews. the sample will be recruited at the orthodontic clinic of bauru dental school, university of são paulo, brazil. a sample of thirty-five patients, between 9 and 13 years old will be selected. the inclusion criteria are: class iii malocclusion associated with anterior crossbite. the participants will be allocated into 2 groups. group 1 will comprise 20 individuals treated with a tooth-bone-borne expander and 2 miniscrews in the mandible group 2 will comprise 15 individuals treated with a tooth-borne expander and 2 miniscrews in the mandible. digital models and cone-beam computed tomography (cbct) will be obtained before (t1) and 12 months after treatment (t2). occlusal radiographs and partial (canine to canine) models will be obtained before and immediately after expansion. two-dimensional cephalometric evaluations will be performed in the dolphin® software. the arch width, arch perimeter and arch length will be analyzed with the orthoanalyzer® software. three-dimensional superimposition at the cranial base of t1 and t2 cbct images will be performed. the inter incisor diastema will be evaluated by occlusal radiographs and dental models. discomfort, pain and quality of life will evaluated by questionnaires. after verifying the normal distribution, the intragroup comparison will be performed with paired t test and intergroup comparison will be performed with t test. in the case of lost to follow-up patients, intention to treat analysis will be used. a significance level of 5% will be regarded for all tests. temporary pain and discomfort are possible after the installation of the miniscrews. patients and legal guardians will be informed. after the consent, the treatment can be stoped at any time.

Eligibility criteria:
inclusion criteria: * both sexes; * ages ranging from 9 to 13 years old; * class iii malocclusion; * mandibular canines erupted. exclusion criteria: * previous orthodontic treatment; * cleft lip and palate; * craniofacial syndromes; * systemic and/or neurological diseases.

Keywords: orthodontic anchorage procedures malocclusion, angle class iii palatal expansion technique. cone-beam computed tomography dental models
healthy volunteers study to estimate the effects of food on the bioavailability of oxycodone and naltrexone/6- β -naltrexol from a extended release formulation of oxycodone with sequestered naltrexone

Conditions: Healthy

Summary: the purpose of this study is to estimate the effects of food and of sprinkling alo-02 pellets on applesauce on the bioavailability of oxycodone and naltrexone/6- beta-naltrexol from an extended release pellets-in-capsule formulation of oxycodone 40 mg with sequestered naltrexone 4.8 mg.

bioavailability

Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between the ages of 18 and 55 years, inclusive exclusion criteria: * evidence or history of clinically significant diseases

Keywords: food effect bioavailability oxycodone sequestered naltrexone management of moderate to severe pain
contrast enhanced intraoperative ultrasound for detection and characterization of renal mass undergoing open partial nephrectomy

Conditions: Kidney Cancer

Summary: the goal of this clinical research is to learn how effective an ultrasound contrast agent, called definity, is when used during ultrasound-guided surgery to remove part of one or both kidneys.

definity is a contrast agent that is used to create better quality ultrasound images. on the day before or the day of the standard of care surgery, women who are able to become pregnant must have a negative blood or urine pregnancy test. if it a blood pregnancy test is performed, a portion of blood will be used from routine blood draws that are collected as part of your standard of care surgery. during your standard of care surgery, the radiologist will take images and videos with an ultrasound machine before you are given the contrast agent. this is done to learn if cancer has spread around the kidney. you will then receive the definity by vein over about 1 minute. after you receive the injection of definity, the radiologist will take more images and videos of the tumor and kidney(s) to compare to those recorded earlier. length of study: your active participation in this study will be over after you have completed the follow-up visit. follow-up phone call: you will have a follow-up phone call 30 days after your standard of care surgery is complete to review any side effects you may be having. this call should take about 10 minutes to complete. this is an investigational study. definity is fda approved and commercially available for use in contrast enhanced echocardiography. it is not fda approved or commercially available for use in radiology. up to 11 patients will take part in this study. all will be enrolled at md anderson.

Eligibility criteria:
inclusion criteria: 1. patients must have previous cross sectional imaging (ct or mri) demonstrating renal mass or masses that is amenable to open partial nephrectomy. 2. patient is scheduled for intraoperative ultrasound guided open partial nephrectomy. 3. patient must sign informed consent, with risks and benefits of ceus explained (see risks outlined on the following pages) exclusion criteria: 1. patients with known renal mass scheduled for total or laparoscopic partial nephrectomy. 2. patients who are hypersensitive to definity (perflutren lipid microsphere) 3. patients with known history of right-to-left, bidirectional or transient right-to-left cardiac shunts. 4. pediatric patients less than 18 years of age. 5. pregnant or nursing mothers.

Keywords: kidney cancer renal mass open partial nephrectomy ultrasound-guided surgery definity contrast agent phone call
sanomechanics® rehabilitative technology

Conditions: Knee Osteoarthritis

Summary: rehabilitative sanomechanics method (rsm) of exercise designed to restore normal subperiosteal transmission of in-joint pressures and normalizing contact pressures on cartilages, will reduce pain in the affected joints and improve locomotor function.

specific aim 1: in a clinical trial with subjects reporting arthritic knee pain, demonstrate that the sanomechanics method of exercise, focused on restoring normal subperiosteal transmission of in-joint pressures, will reduce pain. using the validated womac questionnaire as a patient- reported outcome (pro) tool, the associated primary endpoint is that 80% of patients will report a reduction in pain at the end of the 3-month study based on the 5-point categorical womac pain scale. specific aim 2: to demonstrate that sanomechanics will improve normal synergy in gait by mitigating compensatory gait strategy, which one develops to avoid unbearable pain in the joint. the associated co-primary endpoint is that 80% of patients will experience an increase in stance knee flexion angle. the secondary endpoint is that the 80% of patients will report a lowered womac function score based on 5-point categorical womac scale (lower score corresponds to better self-reported function) after the three-month study.

Eligibility criteria:
inclusion criteria: * unilateral knee pain with womac score 6-9. * knee pain, aching or stiffness on most days in the past month and definite radiographic osteoarthritis in the index knee. * morning stiffness \>30 min. * age: 40-75 years of age. * more pain in the morning compared to evening. * english speakers. * have daily access to an email address and a computer with internet * allowed to be on prescription or non-prescription medicine for pain during the course of the study. exclusion criteria: * inability to communicate in english * lower limb injury, surgery, or intra-articular injection in the past 6-months * current pregnancy * have a pacemaker or other internal medical device * cancer not in remission * gout * history of stroke affecting lower limb * major trauma * gross knee instability on exam * lumbar radiculopathy affecting symptomatic limb * kl radiographic score 4 * morphological indications (bone-on-bone contact) for joint replacement
a study based on medical records that looks at the duration of use of two types of inhalers with different medicines in patients with chronic obstructive pulmonary disease (copd)

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: to compare the persistence in using two different medications from the same drug class (lama/laba fdc) which are delivered through different devices, a dry-powder inhalers (dpi) and soft mist inhalers (smi).


Eligibility criteria:
inclusion criteria: - exclusion criteria: * aged \<40 years * enrolment with medical and pharmacy coverage prior to the cohort entry \< 180 days * never had copd diagnosis on the cohort entry date or prior to cohort entry * a record for dispensed olodaterol/tiotropium bromide delivered with respimat inhalator or umeclidinium/vilanterol delivered with the ellipta inhaler during the 180-day baseline prior to cohort entry * diagnosis of asthma any time prior to cohort entry * diagnosis of lung cancer any time prior to cohort entry * diagnosis of lung transplant any time prior to cohort entry
comparison between magnetic field and laser therapy in management of trigeminal neuralgia

Conditions: Trigeminal Neuralgia

Summary: trigeminal neuralgia (tn) was defined by the international association for the study of pain (iasp) as severe, sudden, usually unilateral, stabbing, brief, recurrent attacks of pain in one or more distributional branches of the trigeminal nerve. the purpose of the current study will to investigate the effect of low level laser therapy versus electromagnetic therapy on diabetic trigeminal neuralgia pain intensity and amplitude of the compound muscle action potential of the masseter and temporalis muscles in diabetic tn patients.


Eligibility criteria:
inclusion criteria: * all participants will between the ages of 25 and 45, will of both sexes (male and female), diabetic type two patients with chronic trigeminal neuralgia, (from three to six months). * patients will awake, cooperative, and free of psychiatric issues (as determined by a psychologist) as well as difficulties resulting from orthopaedic or special sensory deficits. exclusion criteria: * patients will ruled out if they developed tn due to a tumour, herpes zoster, or any other reason other than diabetes, such as significant coagulation dysfunction, cardiopulmonary dysfunction or previous invasive treatment (ethanol, radiofrequency, gama-knife microvascular decompression, glycerinum injection). * they will not have a previous disability in the face.
supporting carers of children and adolescents with eating disorders in austria (succeat)

Conditions: Mental Health

Summary: the purpose of the "supporting carers of children and adolescents with eating disorders in austria" (succeat) - study is to compare workshop, internet-based and conventional parental support groups for carers of chilren and adolescents between 10 and 18 years in a randomized controlled trial for the first time in austria.

according to nice guidelines, eating disordered patients should be managed on an outpatient basis. this challenge seems to put a heavy burden on most caregivers. schmidt and treasure (2006) argued that obsessive compulsive personality traits, emotional avoidance, pro-anorectic beliefs and responses of close others like dysfunctional communication styles impair the outcome. the construct of expressed emotions reflects on the amount of criticism, hostility and emotional over-involvement expressed by relatives of psychiatric patients towards them. a special program for parents is developed to equip caregivers with knowledge and skills to change maintaining factors and therefore improve the patient's outcome. furthermore coping strategies are provided to help carers to reduce their burden. we start a randomized controlled trial comparing two interventions with a conventional group. we compare workshops (intervention group 1), internet-based (intervention group 2) and conventional (control group) carers´ support groups. before starting the intervention (t0, baseline), at the end of the intervention (t1) and 1 year after the intervention (t2, follow up) assessments will be conducted via questionnaires and interviews. parents of 48 children and adolescents within the age group of 10-17 years suffering from anorexia or bulimia nervosa will be involved in each group, resulting in an overall sample size of 144. the investigators aim is to equip parents with knowledge and skills in order to support their children's recovery, prevent relapse and improve their own wellbeing. the long term goal is to provide low-threshold, cost-effective, time-efficient and superregional support for parents in the future.

Eligibility criteria:
inclusion criteria: * children and adolescents aged 10-18, who suffer from anorexia or bulimia nervosa and their primary caregivers exclusion criteria: * no written informed consent possible due to intelligence or no willingness by parents to include minor

Keywords: eating disorders caregivers parents skills training workshops support internet online family
aphtostomatitis and mucositis treatment by natural herbal formula (sorend®)

Conditions: Aphtostomatitis; Mucositis

Summary: sorend is a water-based formula, which contains carob, melissa and sage. elder inhabitants of israel are known to use carob extract to ease sores in the mouth, due to the tannins which create a complex with various proteins and polysaccharides, thus creating an impenetrable layer covering the sores, allowing spontaneous healing.


Eligibility criteria:
inclusion criteria: * herpetic aphtomatitis * bacterial aphtostomatitis * viral aphtostomatitis * fungal aphtostomatitis exclusion criteria: * oncology patients * systematic diseases (colitis, crohn, diabetes, behcet) * pregnancy * arthritis

Keywords: aphtostomatitis mucositis mouth sores natural herbal