Kornimate/medical-research-clean huggingface dataset:
the prediction of anastomotic insufficiency risk after colorectal surgery (panic) study

Conditions: Anastomotic Leak; Colorectal Cancer; Diverticulosis; Crohn Disease; Ulcerative Colitis; Mesenteric Ischemia

Summary: the prediction of anastomotic insufficiency risk after colorectal surgery (panic) study aims to establish a machine-learning-based application that allows for accurate preoperative prediction of patients at risk for anastomotic insufficiency after colon and colorectal surgery.

anastomotic insufficiency leads to clinical strains for patients, and significantly increases morbidity and mortality. on average, hospital stay is extended by 12 days while healthcare-related expenses are increased by 30,000 usd when patients suffer from an anastomotic leak. in experienced centers, the approximated incidence of anastomotic insufficiency is 3,3% for colon and 8.6% for colorectal procedures. multiple subgroups of patients with increased risk for anastomotic leaks have been described in previous publications. meticulous preoperative recognition of patients with increased risk for anastomotic insufficiency is clinically beneficial, as it would permit improved ressource preparation, enhanced patient education and superior surgical decision-making. however, it is often difficult for clinicians to balance the plethora of crucial risk factors for anastomotic leaks for a single patient. machine learning methods have been exceptionally effective at incorporating various clinical variables into one unified risk prediction model. to the authors' best knowledge, there does not yet exist a credible prediction model or a conclusive prediction score for anastomotic insufficiency after colon and colorectal anastomosis. the aim of the prediction of anastomotic insufficiency risk after colorectal surgery (panic) study is to establish and externally validate an efficient machine-learning-based prediction tool based on multicenter data from a range of international centers.

Eligibility criteria:
inclusion criteria: * patients who underwent colon or colorectal anastomosis for neoplasia, diverticulitis, mesenterial ischemia, iatrogenic or traumatic perforation, or inflammatory bowel disease exclusion criteria: * age \< 18 * recurrent colorectal cancer * peritoneal carcinomatosis or unresectable metastatic disease at time of bowel resection * informed consent not obtainable * follow-up \< 6 weeks after surgery * no reversal of and ostomy

Keywords: anastomotic leak
he4 as a relapse biomarker in ovarian cancers

Conditions: Ovarian Carcinoma

Summary: he4 is a more sensitive marker than ca-125 in patients with ovarian cancers. the interest of serum he4 before surgery has been demonstrated to predict overall survival and its interest has also been shown in combination with ca-125 (roma algorithm) to identify high risk patients. to date, no study shows clearly the predictive potential of serum he4 as an early relapse biomarker in ovarian cancers.


Eligibility criteria:
inclusion criteria: * ovarian adenocarcinoma stage iiia, iiib or iv pleural, cytologically or histologically proven * patient scheduled to undergo neoadjuvant chemotherapy based on platinum followed by surgery and adjuvant chemotherapy * age ≥ 18 years . * performance status ecog \> or = 2 * adequate haemoglobin rate ≥ 10 g/dl * ability to provide written informed consent * patient's legal capacity to consent to study participation exclusion criteria: * any previous treatment with platinum for ovarian carcinoma * patient with visceral metastases * contraindication for blood test * contraindication for surgery * contraindication for bevacizumab treatment

Keywords: ovarian carcinoma neoadjuvant roma ca125 he4 biomarker
group cognitive behavioural therapy (cbt) for perinatal anxiety

Conditions: Perinatal Anxiety

Summary: our previous pilot study (n = 40) suggested that group cognitive behaviour therapy for perinatal anxiety (cbt-pa) significantly reduces symptoms of anxiety and depression from pre- to post- intervention. cbt-pa is based on the general principles of cbt but specific themes and examples are geared towards pregnancy and postpartum periods. the 6-week treatment protocol addresses: (1) understanding anxiety during pregnancy and postpartum, (2) self-care, (3) setting goals and facing fears, (4) nurturing the developing relationship with baby, (5) coping with negative thoughts and worries, and (6) relapse prevention. this intervention and all assessment interviews will be conducted via a hospital-approved video-conferencing platform. all assessment questionnaires will be completed on surveygizmo. the objectives of the present study are: (1) to replicate these findings of the pilot study in a larger sample (n = 58) in a randomized controlled trial (rct), (2) compare the effectiveness of cbt-pa to a control treatment (waitlist control), (3) evaluate the durability of treatment gains at 1-month and 3-months after the conclusion of treatment, (4) evaluate patient preferences in terms of the relevance and the acceptability of the cbt-pa protocol, (5) examine whether the degree of childbirth stress impacts patient response to cbt-pa to inform future refinements to the treatment, and (6) determine whether cbt-pa improves maternal efficacy and attachment with baby. this research is being conducted because many women suffer from perinatal anxiety and have difficulty accessing services in a timely manner. it is the hope that the findings of this study will have clinical significance in terms of providing additional support for cbt as an effective treatment for perinatal anxiety. it is the hope that this treatment will have mental and physical health benefits for the mothers directly, as well as mental and physical health benefits to their fetuses and infants.


Eligibility criteria:
inclusion criteria: * adult over the age of 18 years living in the province of manitoba, canada. * must be pregnant or within 12 months postpartum. * women must also meet criteria for at least one anxiety disorder or related disorder (i.e., generalized anxiety disorder, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder). exclusion criteria: * primary perinatal depression * active suicidality and/or homicidality * active psychosis, manic, or a substance use disorder that would interfere with participation in treatment. * women also must not be receiving concurrent psychotherapy * if on medication, must not have made any medication changes in the 6 weeks prior to beginning participation in our study.
effectiveness of myofascial release versus manual lymphatic drainage after breast cancer surgery

Conditions: Fibromyalgia

Summary: objective. to compare the effectiveness of myofascial therapy against manual lymphatic drainage in the reduction of sequelae secondary to conservative surgery and radiotherapy in women who survived breast cancer. design. randomized clinical trial. site. faculty of physiotherapy of the university of valencia. participants. twenty-four patients were included in the study. interventions. 13 patients were randomly assigned to treatment with myofascial therapy and 11 to receive manual lymphatic drainage. main measurements. pain measured using the visual analogue scale, shoulder joint range, shoulder functionality using the dash questionnaire, quality of life assessed using the fact-b questionnaire, and the depressed status of the patients using the phq-9 . all of this was assessed before and after treatment, and one month later as follow-up.


Eligibility criteria:
inclusion criteria: * women between the ages of 30 and 60 diagnosed with breast cancer undergoing conservative / partial surgery. * without lymphedema or mild lymphedema. * they must have finished the coadjuvant treatment. exclusion criteria: * women with muscle or tendon lesions in the arm. * kin disorders or circulatory pathology. * chemotherapy or radiotherapy. * surgical history in the area are excluded from the study.

Keywords: myofascial-reléase fibromyalgia lymphatic drainage breast cancer
clinical trial of the boosting effect of transcranial random noise stimulation (trns) in cognitive rehabilitation of patients with traumatic brain injury

Conditions: Traumatic Brain Injury; Cognitive Impairment

Summary: the main objective of this study is to evaluate the effects of trns while undergoing computerized cognitive rehabilitation therapy to conclude if this combination of therapies would be effective for the cognitive rehabilitation of patients with acquired brain damage, such as traumatic brain injury. we want to study the therapeutic potential of trns to enhance the therapeutic outcome of cognitive training, studying its global effect over the rehabilitation of attention, memory and executive functions, compared to sham trns.


Eligibility criteria:
inclusion criteria: * age over 18 years old * documented history of severe or moderate tbi (severe tbi: glasgow coma scale 3-8; moderate tbi: glasgow coma scale 9-13) * out of post-traumatic amnesia * less than 6 months after tbi * cognitive impairment objectified by neuropsychological exploration. exclusion criteria: * impairment of language, affecting the production and/or comprehension of speech and the ability to read and/or write * severe alteration of the visual field or visual perception problems that limits the use of technological devices * sever motor impairment of both upper extremities that prevent the use of technological devices * previous or current history of psychiatric, neurological or systemic alterations that affect the central nervous system * history of substance abuse * dermatological diseases in the skull * presence of metal implants or holes in the skull * epilepsy.

Keywords: computerized cognitive rehabilitation trns traumatic brain injury tbi cognitive impairment
autologous hematopoietic stem cell transplantation for refractory multiple sclerosis

Conditions: Multiple Sclerosis

Summary: autologous hematopoietic stem cell transplantation (ahsct) is the only treatment for refractory autoimmune diseases capable of inducing long-term, drug-free and asymptomatic remission. over the past two decades, ahsct has been used to treat inflammatory autoimmune disease of the cns. patients with relapsing-remitting multiple sclerosis benefit from ahsct treatment. however, a certain percentage of patients still experience recurrence 3 or 5 years after transplantation. therefore, exploration of conditioning regimens will drive therapeutic advances in ahsct in autoimmune diseases of the cns.


Eligibility criteria:
inclusion criteria: 1. age 18-60 years; 2. diagnosed multiple sclerosis with relapses or progression and sustained accumulated impairment by a neurologist expert in the field; 3. edss score of 3-6 (including 3 and 6); 4. edss cerebellar functional score ≥ 3 or edss pyramidal functional score ≥3； 5. evidence of current disease activity; 6. if a patient has previously received a cytotoxic agent (mitoxantrone, cyclophosphamide etc.) they must have normal bone marrow morphology and cytogenetics before being considered eligible for this study ; 7. no evidence of hepatic inflammation or fibrosis; exclusion criteria: 1. patients with evidence of myelodysplasia or other non-autoimmune cytopenia; 2. patients having received a cytotoxic agent within one month of enrolling in this study; 3. patient with any active or chronic infection (herpes simplex virus, varicella-zoster virus, cytomegalovirus, eb virus, human immunodeficiency virus, hepatitis virus, syphilis, etc.); 4. patients having received a cytotoxic agent within one month of enrolling in this study; 5. patients with a malignant tumor currently or within the last 5 years; 6. patients with cardiac, renal, pulmonary, hepatic or other organ impairment; 7. patients whose life expectancy is severely limited by another conditions; 8. pregnancy or risk of pregnancy; 9. patients unable to give written informed consent in accordance with research ethics board guidelines.
dry eye symptom mitigation by oral intake of probiotics

Conditions: Dry Eye

Summary: this study investigates whether the oral intake of a probiotics capsule product may relieve dry eye symptoms. participants will be aged between 20 - 65 years of age, with confirmed diagnosis of dry eye status. the participants will be assessed for several parameters and asked to take 1 probiotics capsule per day for 35 days. the parameters will include ocular surface health, tear volume, tear quality, intraocular pressure, tear osmolarity and serum biochemical test. after the 35 days are completed, the participants will be assessed again for the same parameters.

this investigation is a randomized, double-blind study. subjects with confirmed diagnosis of dry eye are randomly assigned to control group or treatment group, and asked to orally intake 1 capsule of either placebo or probiotics per day. all participants will be assessed for parameters, including intraocular pressure, ocular surface health, tear film breakup time (tbut), tear volume (schirmer's test), tear osmolarity, ocular surface impression cytology, ocular surface disease index (osdi) and serum biochemical tests for quantification of hyaluronic acid, sialic acid, glutathione contents.the assessments are conducted at day1 for baseline and after the 35-day oral intake. the parameters are used to compare and evaluate whether the probiotics can relieve dry eye symptoms.

Eligibility criteria:
inclusion criteria: * aged between 20 and 65 years * with schirmer's test results less than 10 mm or ocular surface disease index more than 25 exclusion criteria: * evident ocular diseases such as cornea disease, cataract, vitreous degeneration, glaucoma, and retinopathy. * diabetes * hypertension * or other chronic diseases or belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)

Keywords: probiotics dry eye eye sore eye strain
prepl in health and disease

Conditions: Hypotonia-Cystinuria Syndrome; Muscle Hypotonia; Healthy Volunteers; Dwarfism, Growth Hormone Deficiency; Obesity; Prader-Willi Syndrome

Summary: evaluation of prepl activity in healthy controls and known or possible prepl deficient patients

prepl is defective in hypotonia cystinuria syndrome and in isolated prepl deficiency. the investigators have constructed a blood test to evaluate prepl activity in patients with possible prepl deficiency. the study will determine normal values for age (0-18) for prepl activity in blood. also, patients with a clinical phenotype that overlaps with prepl deficiency (including patients with known primary prepl deficiency and prader-willi syndrome) will be evaluated for prepl activity in blood. a last part of the study will involve muscle biopsies during elective anesthesia/surgery for other reasons. there will be 2 groups: patients without signs of prepl deficiency undergoing surgery (controls) and patients with prader-willi syndrome undergoing anesthesia or surgery (patients). the control group will be age-matched to the hypotonia group. in the muscle biopsies, prepl activity and expression will be evaluated.

Eligibility criteria:
inclusion criteria: * according to group * control group: children seen at a postinfectious consultation exclusion criteria: * control group: symptoms overlapping with prepl deficiency, genetic or syndromic disease, atypically developing children * other groups: contraindication for blood draw * group with muscle biopsy: contra-indication for muscle biopsy
fertility after uterine artery embolization

Conditions: Fertility Disorders; Fertility Issues; Myoma;Uterus; Uterine Artery Embolisation

Summary: uterine leiomyomas (or fibroids) are a common disease (30% of women over 35 years of age) in women of childbearing age and can cause various symptoms such as menometrorrhagia, dysmenorrhoea, pelvic pain and heaviness, and infertility. uterine artery embolisation, first used in france in 1990, is a safe, effective and less invasive therapeutic technique than surgical treatment (myomectomy or hysterectomy), particularly in the case of numerous and large fibroids. this technique is validated by the french national college of gynaecologists-obstetricians (cngof) as an alternative treatment for women who do not wish to become pregnant (grade a recommendation), but at present there is little reliable data concerning fertility, the occurrence of pregnancy and the obstetrical prognosis after uterine artery embolisation for fibroids. a recent systematic review of the literature with meta-analysis published very recently showed that 40.5% of patients with a desire for pregnancy were able to become pregnant after embolisation (ci: 33.3%-48.2%) but that the rates of miscarriage, obstetric complications and low birth weight were not negligible (respectively 33.5% (95% ci: 26.3-41%), 25.4% (95% ci = 13-40.2%) and 10% (95% ci = 6.2-14.6%) (ghanaati et al. 2020). in france, uterine artery embolisation is performed in more than thirty centres in women who have completed their parental project. on the other hand, in the absence of consistent literature, it is performed in patients of childbearing age, when it represents the only acceptable alternative or in the event of contraindication or refusal of surgery by the patient. to our knowledge, there is no large-scale french study to date on the impact of embolisation on fertility and pregnancy outcomes. the aim of this study is to compile a retrospective database of all cases of uterine artery embolisation for uterine pathology performed at the georges-pompidou european hospital (hegp) since 2007 and to assess the impact of embolisation on fertility in patients of childbearing age.


Eligibility criteria:
inclusion criteria: * women ≥ 18 years, ≤ 45 years at the time of their embolisation * uterine pathology responsible for disabling symptoms: uterine leiomyomas with no limitations in size, number or location, adenomyosis * having had a uterine artery embolisation between 2007 and september 2020 * minimum delay of one year after embolisation * information and no opposition from patients exclusion criteria: * women \ 45 years at the time of embolisation * uterine artery embolisation for delivery haemorrhage * patients under court protection, guardianship or curatorship * refusal to participate in this research

Keywords: uterine artery embolisation fertility issues fertility disorders uterine myoma
value of tomosynthesis for the detection of sacro-iliitis (tomos si)

Conditions: Sacroiliitis

Summary: spondyloarthropathies (spas) are chronic inflammatory diseases encompassing ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthropathy, and undifferentiated spa. in 2001, the estimated prevalence of spa was 1.5% worldwide. sacroiliitis is a condition caused by inflammation within the sacroiliac joint. it is the most frequent damage of spa depicted at imaging evaluation. conventional radiography (x-ray) is usually used to depict the structural changes associated with sacroiliitis. however further evaluation often requires additionnal computed tomography (ct). tomosynthesis is an xray-based imaging technology which allows reconstruction of multiple section images from a set of projection images acquired as the x-ray tube moves along a prescribed path. the advantagee of tomosynthesis is the significant reduction of radiation dose exposure compared to ct tomosynthesis is currently used in the field of breast imaging and pneumology. very few studies have examined the value of tomosynthesis for osteoarticular imaging. the study aims at evaluating the diagnostic performances of tomosynthesis as compared to standard x-ray and ct, in patients with a clinical suspicion of sacroiliitis. the investigators hypothesize that tomosynthesis is superior to conventional radiography for detection of sacroiliitis and is at least equal to ct with lower irradiation.

consecutive patients referred to ct for exploration of sacrollitis will be included and investigated with standard radiography, ct and tomosynthesis of si joints. imaging examinations will be performed at day of enrollment as follow : x-ray and ct as standard management and tomosynthesis as additional evaluation. ct will be considered as the reference standard sacroiliitis will be assessed in a centralized, blind and randomized retrospective reading of all imaging modalities by two independent radiologists. diagnostic performances and radiation doses of tomosynthesis will be compared to those of standard ct and x-ray examinations.

Eligibility criteria:
inclusion criteria: * patients aged 18 and over referred for suspected sacroiliitis. * patients who have entered into their participation agreement by signing the informed consent form. * patient affiliated to a social security scheme or beneficiary. exclusion criteria: * pregnant or lactating women. * vulnerable people according. * major people placed under guardianship or curatorship.

Keywords: sacroiliitis si joint tomosynthesis ct xray
single dose study to study the absorption, metabolism and excretion of pf-04991532

Conditions: Healthy

Summary: the purpose of this study is to evaluate the excretion balance, metabolic profile and the routes of excretion of \[14c\]pf-04991532 in healthy adult male subjects.


Eligibility criteria:
inclusion criteria: * healthy male subjects between the ages of 18 and 55 years, inclusive (healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ecg and clinical laboratory tests). * body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg(110 lbs). * an informed consent document signed and dated by the subject. exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing) or clinical findings at screening. * history of irregular bowel movements (eg, irritable bowel syndrome or frequent episodes of diarrhea or constipation). * any condition possibly affecting drug absorption (eg, appendectomy, gastrectomy).

Keywords: diabetes mellitus adme
evaluation of plasma catecholamine concentration during surgery

Conditions: Stress

Summary: stress during surgery leads to significant increase in plasma catecholamine concentrations in surgeons, anesthesiologists, and patients.

hypothesis: resection of pheochromocytomas can lead to more than normal stress in surgeons and because of abrupt hemodynamic changes in patients as well in anesthesiologists. measurements of catecholamine concentrations at baseline, prior to surgery during and after surgery, are to be performed to test this hypothesis.

Eligibility criteria:
inclusion criteria: patients with pheochromocytoma (older than 18 years) - exclusion criteria: patients younger than 18 years. conservative treatment. -

Keywords: epinephrine, norepinephrine, normetanephrine catecholamine concentrations during surgery