Kornimate/medical-research-clean huggingface dataset:
text messaging adherence to stimulant medication

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to determine if an individualized text messaging intervention for the parents of children with attention deficit/hyperactivity disorder is effective in improving medication adherence and disease management.


Eligibility criteria:
inclusion criteria: * male or female children ages 6-17 years * a diagnosis of adhd (inattentive, hyperactive/impulsive, or combined type) according to the diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) based on clinical assessment and supported by a clinical global impression- adhd (cgi-adhd) severity score of at least 4 (moderately ill) * has a parent in possession of a cellular phone with text messaging capabilities and is interested in and willing to receive planned text messages * has never been treated with stimulant medication, or has begun treatment with stimulant medication within three months of study enrollment. exclusion criteria: * any serious, unstable, chronic medical condition, per clinician assessment * cardiovascular disease * current or past history of seizures * treatment with stimulant medication beyond three months prior to enrollment * pregnant or nursing females * investigator and his/her immediate family; defined as the investigator's spouse, parent, child, grandparent, or grandchild * unstable psychiatric illness other than adhd, including, but not limited to: autism, bipolar disorder, psychosis, major depressive disorder, anorexia, bulimia, post-traumatic stress disorder and anxiety disorders * history of multiple adverse drug reactions * presence of suicidal risk, or homicidality * unwilling/unable to comply with study procedures * poor command of the english language

Keywords: attention deficit hyperactivity disorder medication adherence disease management text message adhd children reminder systems text messaging telemedicine
yellow pea protein and fibre and short term food intake

Conditions: Obesity; Type II Diabetes Mellitus; Metabolic Syndrome

Summary: it is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.

a within-subject, randomized study was conducted. each subject returned 5 times, 1 week apart, and received 1 of the 5 treatments per week. the 5 treatments were tomato soup with 10 or 20 g of isolated yellow pea fibre or protein, or a control soup with no added pea fractions. food intake was measured at an ad libitum pizza meal served 30 minutes after treatment. satiety and blood glucose (via finger prick) were measured throughout the treatment period.

Eligibility criteria:
inclusion criteria: * male 20-30 years old healthy weight exclusion criteria: * smoking restrictive eating metabolic diseases breakfast skippers dieters

Keywords: obesity food intake regulation blood glucose regulation protein fiber pulses yellow peas
immunological measurement of aspartate/alanine aminotransferase

Conditions: Chronic Liver Disease and Cirrhosis

Summary: previous reports have suggested that alt-immunoglobulin complex was increased according to the severity of the liver disease, and high concentration of mast and this might indicate a severely damaged liver. immunoassay might be useful as a screening method in the differ-ential diagnosis of liver fibrosis according to patients. in this study, the efficacy of immunoas-say in the prediction of liver fibrosis in patients with chronic hepatitis b (chb) was evaluated.

enzymatic analysis of aspartate/alanine aminotransferase (ast/alt) does not exactly represent the progression of liver fibrosis. immunoassay for the ast (cytoplasmic \[c\] ast/mitochondrial \[m\] ast) and alt (alt1/alt2) have been suggested as one of the alternatives for the enzy-matic analysis. we evaluated the efficacy of immunoassay in predicting liver fibrosis and in-flammation. a total of 219 patients with chronic hepatitis b (chb) who underwent hepatic ve-nous pressure gradient (hvpg) and liver biopsy before antiviral therapy were recruited. serum samples were prepared from blood during hvpg. the liver function test including enzymatic ast/alt and immunological cast, mast, alt1 and alt2 were checked with sandwich eli-sa immunoassay with fluorescence labeled monoclonal antibodies, and were compared with the metavir stage of live fibrosis and the knodell grade of inflammation.

Eligibility criteria:
inclusion criteria: * patients with chb, who simultaneously underwent hvpg and liver biopsy for the routine check-up prior to antiviral treatment, were prospectively recruited. exclusion criteria: * patients were selected according to inclusion criteria with chb and then excluded according to exclusion criteria: i. they had other cause with liver disease: ii. decompensated cirrhosis and re-ceived antiviral treatment within the previous 6 months. iii. malignancy

Keywords: chronic hepatitis b alanine aminotransferase aspartate aminotransferase
evaluation of the omnipod dash in children and adolescents with type 1 diabetes mellitus

Conditions: Diabetes Mellitus, Type 1; Children; Metabolic Control; Patient Satisfaction

Summary: in this study the usability of the omnipod dash insulin administration system is evaluated prospectively by two questionnaires. the effect on the metabolic control is evaluated retrospectively by analysis of data from the medical records of the patients.

in the study the usability of the omnipod dash (= insulin patch pump) is evaluated prospectively by two questionnaires. the first questionnaire concerns practical items on the application of the pump (e.g. is it easy to fill to pod?), the wearing of the pump (e.g. is it comfortable to wear the pump?) and the comparison with insulin administration with insulin pens or other insulin pumps (e.g. is it less painful to administrate insulin by the omnipod dash pump). the second questionnaire asks for possible problems that the patients experienced during the wearing of the pump (e.g. did you experience an allergic skin reaction). the questions are formulated to be answered by a 5-point likert scale. the metabolic control is studied retrospectively from data extracted from the medical records, i.e. the results of the determination of hba1c and the results from continuous glucose monitoring (cgm) at the start, and after 2, 4 and 6 months of the wearing of the omnipod dash insulin pump.

Eligibility criteria:
inclusion criteria: * children and adolescents with type 1 diabetes mellitus * patients who started in 2021 with the omnipod dash insulin administration system in the jessa hospital exclusion criteria: * children and adolescents without type 1 diabetes mellitus * children and adolescents with type 1 diabetes treated with insulin pens or other insulin pumps

Keywords: type 1 diabetes mellitus child insulin administration omnipod dash usability metabolic control
long-term safety of gevokizumab in the treatment of patients with chronic non-infectious uveitis (eyeguard-x)

Conditions: Chronic Uveitis

Summary: the objective of this study is to evaluate long-term safety of gevokizumab in patient with chronic non-infectious uveitis who previously well tolerated the study drug and may benefit from longterm treatment with gevokizumab.


Eligibility criteria:
inclusion criteria: * either completed participation to one of the following: cl3-78989-002 open-label extension, or x052130/cl3-78989-005 double-masked period or open-label period, or x052131/cl3-78989-006 double-masked period or open-label period, or currently benefiting from gevokizumab compassionate use after participation in gevokizumab uveitis studies * male or female, age ≥18 (or legal age of majority in the country) at selection. * for subject with reproductive potential, a willingness to use highly effective contraceptive measures exclusion criteria: * meeting criteria for discontinuation of any of gevokizumab uveitis previous study. * infectious uveitis and masquerade syndrome * history of severe allergic or anaphylactic reaction to study drug administration during previous study or to gevokizumab or any of its excipient. * currently active infectious disease. other protocol-defined inclusion/exclusion criteria may apply

Keywords: uveitis non-infectious uveitis intermediate uveitis posterior uveitis behçet's disease uveitis
study about treatment of newly diagnosed non cutaneous peripheral t cell lymphoma

Conditions: Peripheral T Cell Lymphoma

Summary: this is a multicenter randomized trial evaluating induction treatment with vip-reinforced-abvd (vip-rabvd) versus chop/21 in patients with newly diagnosed peripheral t cell lymphoma.

induction therapy: arm 1: 6 chemotherapy courses = 3 vip alternated with 3 abvd arm 2: 8 chemotherapy courses = chop every 21 days consolidation therapy: for all patients if cr = radiotherapy 40gy / 5x1,8 gy per week

Eligibility criteria:
inclusion criteria: * newly diagnosed untreated ptcl * age 18 and 70 years * performance status ≤ 2 * ann arbor stage i to iv * normal cardiac ventricular ejection fraction over 50% * normal hepatic function (asat, alat, pal \< 2.5 uln) exclusion criteria: * cutaneous form of ptcl * previous treatment * age \ 70 * performance status \> 2 * abnormal cardiac or hepatic functions * hiv-, hcv- or hbv- positivity
office hysteroscopy in infertility work-out: the role of endometrial hyperplasia in southern italian women

Conditions: Infertility, Female; Endometrial Hyperplasia; PCOS

Summary: to assess the prevalence of endometrial hyperplasia (eh), endometrial intraepithelial neoplasia (ein) and endometrial carcinoma between obese and not obese women undergoing ivf techniques for primary or secondary infertility.

endometrial cancer and pre-neoplastic diseases represent the most incident gynecologic malignant pathologies found in women.1 although diagnosed in postmenopausal patients, it can be also found in younger patients, especially when associated with some risk factors. those include weight gain and lifestyle habits, such as consumption of fatty foods that increase estrogen levels. the positive association be- tween infertility and ec is well established. infertile women with irregular menstrual periods, oligomenorrhea, or chronic anovulation have a risk of developing a prospective cohort study conducted at "fertility center, ob/gyn unit, department of woman, child and general and specialized surgery, university of campania "luigi vanvitelli", naples, italy".

Eligibility criteria:
inclusion criteria: * women undergoing office hysteroscopy prior to ivf techniques exclusion criteria: * severe comorbidities (i.e. cardiac, metabolic, neurologic diseases)
effectiveness of cultural sensitive collaborative treatment of depressed chinese

Conditions: Depression

Summary: this study is a randomized controlled trial to test whether culturally sensitive collaborative treatment (csct) would improve the outcome of depressed patients visiting non-psychiatric settings in taiwan.


Eligibility criteria:
inclusion criteria: * patients who attend non-psychiatric clinics at the above site. * patients with major depressive disorder (mdd), defined as a positive screen using the phq-9, confirmed with the scan interview. * men or women aged 18 or older. * able to participate in a clinical diagnostic interview in either mandarin or fukienese dialects. * individuals who are willing to be followed up concerning their depression symptoms. * individuals who have completed a written consent form. exclusion criteria: * women who are pregnant, breast-feeding, or planning pregnancy within the next year. * patients with serious suicidal risk. * patients with unstable medical illnesses. * clinical or laboratory evidence of hypothyroidism. * patients with comorbid severe mental disorders * patients with history of treatment by a psychiatrist in the past 4 months.

Keywords: non-psychiatric clinics
a study to evaluate the efficacy and safety of oxabact in patients with primary hyperoxaluria

Conditions: Primary Hyperoxaluria

Summary: this study will evaluate the efficacy and safety of oc5 in patients with ph.

to evaluate the efficacy of oxabact following 52 weeks treatment in subjects with maintained kidney function, but below the lower limit of the normal range (estimated glomerular filtration rate \[egfr\] \< 90 ml/min/1.73 m2) and a total plasma oxalate (pox) concentration ≥ 10 μmol/l. parameters to be evaluated include the ability to stabilise/reduce pox concentration, to stabilise/improve kidney function and to reduce oxalate deposits in primary hyperoxaluria (ph) subjects.

Eligibility criteria:
inclusion criteria: 1. signed informed consent (as applicable for the age of the subject) 2. a diagnosis of ph (as determined by standard diagnostic methods). 3. egfr \< 90 ml/min/1.73 m2. the schwartz formula will be used to estimate gfr for children (age below 18), and ckd-epi formula will be used for adults (age 18 or above). 4. plasma oxalate concentration ≥10 μmol/l in total plasma oxalate. 5. male or female patients ≥ 2 years of age. 6. patients receiving vitamin b6 must be receiving a stable dose for at least 3 months prior to screening and must not change the dose during the study. patients not receiving vitamin b6 at study entry must be willing to refrain from initiating pyridoxine during study participation. exclusion criteria: 1. inability to swallow size 4 capsules. 2. subjects that have undergone transplantation (solid organ or bone marrow). 3. patients requiring dialysis or at immediate risk for kidney failure or expected to be in need of dialysis during the study period. 4. the existence of secondary hyperoxaluria, e.g. hyperoxaluria due to bariatric surgery or chronic gastrointestinal diseases such as cystic fibrosis, chronic inflammatory bowel disease and short-bowel syndrome. 5. use of antibiotics to which o. formigenes is sensitive. (this includes current antibiotic use, or antibiotics use within 14 days of initiating study medication). 6. current treatment with a separate ascorbic acid preparation. 7. pregnant women (or women who are planning to become pregnant) or lactating women. 8. women of childbearing potential who are not using adequate contraceptive precautions. please see section 7.3 regarding requirements for contraception. 9. presence of a medical condition that the investigator considers likely to make the subject susceptible to adverse effect of study treatment or unable to follow study procedures or any condition that is likely to interfere with the study drug mechanism of action (such as abnormal gi function). 10. participation in any interventional study of another investigational product, biologic, device, or other agent within 60 days prior to the first dose of oc5 or not willing to forego other forms of investigational treatment during this study.
effect of a social script ipad application for children with autism spectrum disorder

Conditions: Anxiety

Summary: the purpose of the research is to test the effectiveness of the social story intervention delivered using the ipad application "going to imaging" on the anxiety, challenging child behaviors, child injuries and completion rates among children with asd undergoing medical imaging procedures. a secondary purpose is to test the effect of this intervention on the anxiety levels of the parents of asd children undergoing medical imaging procedures. hypotheses: h1: children with asd who are exposed to a story book "here the investigators go to medical imaging (x-ray)" to prepare for medical imaging compared with children with asd exposed to treatment as usual (tau) will have: 1. lower anxiety as measured by heart rate respiratory rate, and blood pressure (baseline compared to up to two hours later). 2. exhibit fewer challenging behaviors as measured by a behavior observation scale (developed for the study (up to 2 hours after baseline) 3. higher procedure completion rate. 4. shorter time to complete a procedure. 5. less child injuries. h2: compared to parents of asd children exposed to treatment as usual (tau), parents of children with asd who are exposed to a story book "here the investigators go to medical imaging (x-ray)" to prepare for medical imaging will have: 6. lower state anxiety as measured by the state anxiety inventory ( baseline ).

parent state anxiety is measured at baseline with the 20-item state anxiety measure from www.mindgarden.com. child anxiety is measured at baseline with vital signs (heart rate, blood pressure, respiratory rate). behaviors will be observed and recorded on the behavior observation tool up to 2 hours after the baseline measure (during the imaging).

Eligibility criteria:
inclusion criteria: * children with autism spectrum disorder * english speaking parent or guardian. exclusion criteria: * non-english speaking parent or guardian * severe autism as defined by caregiver or health care provider.

Keywords: child anxiety challenging behaviors time parent anxiety
bronchial inflammation in patients with bronchiolithis obliterans

Conditions: Bronchiolitis Obliterans

Summary: the investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control group. the investigators will perform a pulmonary function test (body plethysmography with tlco), and measure the fraction of exhaled nitric oxide (eno). further a blood sample is drawn to determine the systemic inflammation. finally induced sputum is collected and a cell count is performed, and cells and supernatants are analyzed for inflammatory markers. this investigation will be repeated after 4-6 weeks. the aim of this study is to define baseline values and the variability of possible outcome parameters for future interventional studies.

the purpose of this study is to characterize the variability of lung function values and bronchial inflammation of 20 patients with bronchiolitis obliterans aged between 6 up to 25 years. the patients' data will be compared with the results of a reference group with similar age conditions to determine possible outcome-parameters for following interventional studies. the sputum samples will be processed and quantitatively analyzed to get a profile of the cytological composition. (sputum and serum samples are analyzed by quantitative real-time polymerase chain reaction (pcr) (qrt-pcr) and by cytometric bead assay (cba).) methods and work programme: this study consists of two study visits (v1 and v2) v1: * measurement of nitric oxide in expired air (eno) * lung function testing with spirometry and body plethysmography * bronchodilation * lung function testing with spirometry and body plethysmography * blood test: blood count, crp, rast, serum inflammatory mediators, (genetic markers of the non-specific pulmonary defense system) * induced sputum for inflammatory mediators and microbiological investigations v2: * measurement of nitric oxide in expired air (eno) * lung function testing with spirometry and body plethysmography * bronchodilation * lung function testing with spirometry and body plethysmography * induced sputum for inflammatory mediators and microbiological investigations

Eligibility criteria:
inclusion criteria: * informed consent * between 6 and 25 years of age * known bronchiolitis obliterans * no bronchiolitis obliterans(depending on the study group) * ability to perform lung function tests and inhalation exclusion criteria: * acute illness with systemic or bronchial inflammation * every chronic condition or infection (eg hiv, tuberculosis, malignancy) * pregnancy * known alcohol and/ or drug abuse * inability to understand the extent and scope of the study * participation in another study

Keywords: bronchial inflammation bronchiolitis obliterans sputum blood inflammation adaptive immune system innate immune system
aromatherapy with lavender essential oil as a complementary treatment for the control of dental anxiety

Conditions: Dental Anxiety

Summary: dental anxiety is a common problem in dental care, the aim of this protocol is to evaluate the effect of lavender for the control of anxiety during a surgical dental extraction.


Eligibility criteria:
inclusion criteria: * volunteer to take part in the study * healthy patients * patients signing the informed consent * patients who need surgical removal of third molars exclusion criteria: * hypertensive patients * patients with nasal congestion problems * patients allergic to lavender. * patients under treatment with anti depressants

Keywords: aromatherapy lavender anxiety
bypassing anesthesiologist assessment before cataract surgery: a non inferiority study

Conditions: Cataract

Summary: this study aims to demonstrate that presurgical assessement of patients' risk factors and surveillance during surgery, both performed by nurses, are not inferior to anesthetic team's care, concerning the rate of complications in cataract surgery with topical anesthesia. the nurse performs the triage of patients based on a chart of risk factors assessment. the triage, according to the presence or not of risk factors, leads to patients' care by an anesthetic team (medical anesthesist for pre-surgical assessement and anesthetic nurse for surveillance during surgery) or to patients' pre-surgical assessement and surveillance during surgery both performed only by nurses. in the control group, all patients are taken care of by an aesthetic team, with medical pre surgical assessement and surveillance during surgery both performed by anesthetic nurses.


Eligibility criteria:
inclusion criteria: * age \> 18 years old * cataract surgery scheduled with topical anesthetics * outpatient surgery exclusion criteria: * presurgical nurse assessment leading to the need for the anesthetic staff presence during surgery * general, peribulbar or other locoregional anesthesia required by patient's condition * concomitant surgery planified (glaucoma, vitrectomy...) * patient's refusal to participate in the study * no health insurance coverage
pupil dilation for treatment of ifis

Conditions: Intraoperative Floppy Iris Syndrome

Summary: a novel intervention for targeting the treatment of intraoperative floppy iris syndrome.

this study explores the effects that medication can have on increasing pupil dilation. pupil dilation size is important for operative eye procedures. decreased pupil size is related to increased complication risks in eye surgery. by exploring novel pupil dilation techniques, there is a potential to counteract the effects of poor pupil dilation that is caused by medications such as alpha-blockers. intraoperative floppy iris syndrome is a syndrome characterized by a floppy iris (ifis) and poor pupil dilation during surgery that is caused by bph medications. this study evaluates treatment methods targeting ifis.

Eligibility criteria:
inclusion criteria: 1. adults (18 years old or greater) 3. history of having taken, or currently taking any systemic alpha blocker 2. ability to consent themselves 3. ability to apply eye drops themselves tid for 7 days exclusion criteria: 1. subjects with untreated hypertension or baseline bp \>160 2. subjects with thyrotoxicosis 3. pregnant women or women trying to conceive 4. prisoners 5. inability consent 6. subjects with anatomical narrow angles or who have never had a dilated eye exam 7. subjects currently prescribed brimonidine tartrate for glaucoma 8. subjects who take topical or systemic alpha agonists 9. patients who take monoamine oxidase (mao) inhibitors 10. patients with known severe cardiovascular disease