Kornimate/medical-research-clean huggingface dataset:
safety and feasibility of the use of the dual robotic arm accessory with the levita magnetic surgical system in laparoscopic procedures

Conditions: Bariatric Surgery Candidate; Cholelithiases; Other Disease

Summary: the purpose of this study is to evaluate the safety and feasibility of the levita dual robotic arm accessory (draa) used with the levita magnetic surgical system (mss)

prospective, multi-center, single-arm, open label study designed to assess the safety and feasibility of the use of the dual robotic arm accessory with the levita magnetic surgical system in laparoscopic procedures

Eligibility criteria:
inclusion criteria: * • subject is at least 18 years of age * subject is scheduled to undergo elective laparoscopic procedure * subject signs a written informed consent form (icf) to participate in the study prior to any study required procedures exclusion criteria: * • subjects with pacemakers, defibrillators, or other electromedical implants * subjects with ferromagnetic implants * subjects with significant comorbidities: cardiovascular, neuromuscular, chronic obstructive pulmonary disease, and urological disease (renal failure) * subjects with a clinical history of impaired coagulation confirmed by abnormal blood tests * subject has an anatomical abnormality or disease of intended target tissue noted after initiation of index procedure that would prevent device use * subject is pregnant or wishes to become pregnant during the length of study participation * subject is not likely to comply with the follow-up evaluation schedule * subject is participating in a clinical trial of another investigational drug or device prisoner or under incarceration
reimagining interventions for support and education in hypersensitivity pneumonitis

Conditions: Hypersensitivity Pneumonitis

Summary: the central hypothesis is that a peer coach-delivered intervention that includes cognitive behavioral principles combined with theory-driven patient education will improve health-related quality of life (hrqol) of patients with hypersensitivity pneumonitis (hp). the goal of this behavioral and educational intervention, rise-hp, is to improve health-related quality of life in people who have hypersensitivity pneumonitis and assess feasibility and accessibility of this intervention. patients with hypersensitivity pneumonitis (hp) experience uncertainty, feelings of anxiety and depression, and marked disruption to their lifestyle and home environment. poor health-related quality of life (hrqol) in hp is also driven in part by patients' profound lack of knowledge about the disease. existing interventions for patients with hp do not target improvement in quality of life. participants will complete either rise-hp, a 10-session peer coach delivered behavioral and educational intervention to improve hrqol in hp, or staying well, a 10-session general health education program.


Eligibility criteria:
inclusion criteria: * have documented diagnosis of hypersensitivity pneumonitis by treating clinician. * age 18 or older. * english speaking. * willing to work with a peer coach. * have a working smart phone or tablet. * have access to the internet. * reside or live in the united states. * endorse verbal approval from treating physician to participate in patients' goal movement/physical activity. * meet one or more of the following criteria: * baseline score on the phq8 of \<20 exclusion criteria: * does not have hypersensitivity pneumonitis * younger than age 18 * severe cognitive impairment as determined by their treating physician. * participants with severe depression (phq-8 score ≥20) will be ineligible for the study and will be referred to alternative sources of care. * anyone with documentation in their medical chart of an eating disorder, active substance use disorder, suicidality, homicidality, acute posttraumatic stress disorder, or episodes of mania or psychosis. * anyone who is determined to be severely ill or moribund by the treating clinician.
a study to evaluate the safety and efficacy of ruxolitinib cream with phototherapy in participants with vitiligo

Conditions: Vitiligo

Summary: the purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream with or without phototherapy in adolescent and adult participants with non-segmental vitiligo for whom vitiligo area (facial and nonfacial) does not exceed 10% body surface area (bsa).


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of nonsegmental vitiligo with depigmented area including all of the following: 1. ≥ 0.5 f-vasi on the face 2. ≥ 3.0 t-vasi (body areas not including the face) 3. total body vitiligo area (facial and nonfacial) not exceeding 10% bsa. * agree to discontinue all agents used to treat vitiligo from screening through the final safety follow-up visit. over-the-counter preparations deemed acceptable by the investigator and camouflage makeups are permitted. exclusion criteria: * no pigmented hair within any of the vitiligo areas on the face. * other forms of vitiligo (eg, segmental) or other differential diagnosis of vitiligo or other skin depigmentation disorders. * used depigmentation treatments (eg, monobenzone) for past treatment of vitiligo or other pigmented areas. * previous adverse reaction to nb-uvb phototherapy that caused discontinuation of therapy. * lack of response (little or no repigmentation) to prior nb-uvb phototherapy. * history of thromboembolic events (eg, deep vein thrombosis, pulmonary embolism, ischemic stroke, myocardial infarction). * any other skin disease that, in the opinion of the investigator, would interfere with the study cream application or study assessments. * active acute bacterial, fungal, or viral skin infection (eg, herpes simplex, herpes zoster, chicken pox) within 1 week before baseline. * any serious illness or medical, physical, or psychiatric condition(s) that pose a significant risk to the participant; or interfere with interpretation of study data. * recent use of topical or systemic medications (including biologics or jak inhibitors), or laser or phototherapy to treat vitiligo. note: recent may be defined differently for different treatments. * specific protocol-defined chemistry, hematology, and serological lab values. * those who are pregnant, lactating or considering pregnancy during the period of study participation.

Keywords: non-segmental vitiligo hypopigmentation pigment disorders skin diseases jak inhibitor
analysis of treatment outcomes in patients affected by molar-incisor hypomineralization (mih)

Conditions: Hypomineralization of Enamel; Dental Fear; Quality of Life

Summary: the aim is to long-term evaluate extraction or restoration therapy, of first permanent molars with extensive treatment needs as a result of severe mih in a national multicenter study concerning dental fear and anxiety, oral health-related quality of life, jaw development, and health economics.

first permanent molars often show areas of porous and hypomineralized enamel. this manifests itself clinically as whitish-yellow to brownish well-defined spots and, in severe disorders, disintegration of enamel. one to all molars are affected and at the same time, the permanent incisors may show opacities. the condition is called molar-incisor hypomineralization (mih) and occurs in 14% of children globally. affected teeth create problems for the individual. the teeth are often painful, e.g. when brushing teeth, cold food/drink, or even when inhaling cold air. dental treatment can be painful because it is difficult to get adequate anesthesia, probably due to subclinical pulp inflammation caused by the porosity of the enamel. molars with severely demineralized enamel need dental care shortly after they have erupted due to decay and subsequent caries. 9-year-old children with severe mih had their pfm treated almost ten times as often as a healthy control group. in case of widespread decay and hypersensitivity, extraction may be a treatment option. two retrospective studies dealing with the extraction of first permanent molars due to mih have been published: one study found that 87% showed acceptable gap closure and another study showed that 3 of 27 extraction cases had an objective need and only one case had a subjective need for orthodontic gap closure after the extraction. a review article discusses the scientific basis for treating severe first permanent molar due to severe mih, and the author claims that both the profession and the public today believe in a more conservative restorative treatment. however, he states that there is a need for well-controlled long-term studies. the aim is to long-term evaluate extraction or restoration therapy, of first permanent molars with extensive treatment needs as a result of severe mih in a national multicenter study concerning dental fear and anxiety, oral health-related quality of life, jaw development, and health economics.

Eligibility criteria:
inclusion criteria: * age 6-9 years * diagnosed with at least one first permanent molar with mih defree 4-6 exclusion criteria: * dental agenesis * general disorders, including chronic diseases and functional limitations
how to get started: identifying the critical ingredients to improve gait initiation in parkinson disease

Conditions: Parkinson Disease

Summary: the purpose of this study is to understand the treatment approach (i.e., targeting gait or targeting the postural adjustment prior to gait) that is most effective at improving gait initiation dynamics in people with parkinson disease. ten adults with idiopathic parkinson disease who self-report difficulty initiating gait will complete the study. the investigators will be using a randomized crossover design, where the participants will participate in two series of training (i.e., postural training and steady-state gait training) with a one-week washout between trainings. investigators will evaluate the changes induced in gait initiation postural adjustment size, first step length, and first step speed from each intervention. due to the anticipated limitation of steady-state walking to directly address postural adjustment amplitude, it is hypothesized that training for larger amplitude weight shift during gait initiation will yield improved gait initiation dynamics compared to training with large amplitude movements during steady-state walking.


Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic parkinson disease characterized by asymmetrical onset of at least 2 of 3 cardinal signs (resting tremor, bradykinesia, or rigidity) with no atypical signs or exposure to dopamine-blocking drugs * the presence of mild to moderate gait or balance impairment (a rating of 1-2 on mds unified parkinson disease rating scale (mds-updrs) item 10 \[gait\] or rating 1-3 on item 12 \[postural stability\] * hoehn \& yahr stages 1-3 ("on" for those who fluctuate) * self-report of difficulty with freezing of gait (i.e., a rating of 1-4 on question 3 of the freezing of gait questionnaire) * all participants must be able to walk \> 5 minutes at greater than or equal to 80% of comfortable gait speed (cgs) on the treadmill and \> 5 minutes over ground without assistance or an assistive device. exclusion criteria: * uncontrolled cardiorespiratory/metabolic disease, vestibular dysfunction that may affect gait or balance * parkinson's related or unrelated dementia (i.e. montreal cognitive assessment score \<21) * comfortable over ground walking speed of less than 0.5m/s * history of traumatic brain injury * self-reported deafness or blindness as this would impair the patient's ability to hear cues or ambulate safely within the lab environment * other neurological disorders or orthopedic injury that may affect gait * recent orthopedic surgery (in the last 6 months) * participants will also be excluded if they have severe communication impairments, which could impede understanding of the purpose or procedures of the study or an inability to comply with experimental procedures * participants who are currently receiving supervised physical therapy services

Keywords: freezing of gait gait initiation
the added value of intraoperative ct scanner and screw navigation in operative treatment of displaced acetabular fracture with dome impaction

Conditions: Acetabular Fracture; Acetabular Surgery

Summary: the acetabulum fracture result from a trauma with high energy at the young adult or from a trauma of low energy at the old osteoporotic patient. anatomic reduction is known to be necessary to give functional result to patient.however, it's technically difficult because of the pelvic bone conformation. the presence of dome impaction makes the surgery more difficult. per operatory scanner associated to 3d navigation is proved his value-added in spinal surgery.the aim of the study is show that this association permit a technical improvement for the surgeon in the precision of fracture reduction.and restore the articular congruence.


Eligibility criteria:
inclusion criteria: * age\> 18 * surgery for acetabular fracture within 30 days * with dome impaction exclusion criteria: * disability of inferior limb
establish the referenc range of antiphospholipid antibody in healthy preganany women

Conditions: Focus Health Pregancy Women

Summary: the study is aim to establish 95th and 99th percentile for healthy pregancy women for antiphospholipid antibodies(apls), such as acl igg/m/a, b2gp1 igg/m/a, aps/pt igg/m. the outcome of the study is expected to aid antiphospholipid syndrome patients diagnosis and managment. we also include some obstetirc antiphospholipid syndrome(aps) patients to analysis the correlation between antiphospholipid antibodies and pregancy outcome, also want to know the prevalenc of apls, which can be guide for clinical application for aps diagnosis and treatment.


Eligibility criteria:
inclusion criteria: * 120 non-pregnant healthy women, age 18-45, with at least 1 successful pregnancy , no history of adverse pregnancy outcome, no abortion, still birth, premature delivery, preeclampsia * 120 pregnant women, age 18-45, follow through the pregnancy and successful delivery without any adverse pregnancy outcome during the pregnancy process, no abortion, still birth, premature delivery, preeclampsia, no drug treatment * 60 aps pregnant patients diagnosed by clinical department exclusion criteria: 1. thrombosis history 2. rheumatic immune disease 3. use oral contraception or biological inhibitors 4. history of abortion, adverse pregnancy outcome, common high blood pressure, diabetes
power over pain portal: a stepped-care virtual solution to deliver early intervention to canadian youth with chronic pain

Conditions: Chronic Pain

Summary: the covid-19 pandemic is presenting one of the greatest threats to youth mental health seen in generations. pain is one of the most common symptoms of extreme stress in youth. in 2020, the investigators created an online "stepped-care" program called the power over pain portal. stepped care is a promising way to improve access to cp care. stepped care tailors care based on a person's symptom severity. like a ladder, a person must start with one type of care then "step up" or "step down" to more or less intense care depending on need. the investigators also summarized all online pain management programs for youth to find the best resources to embed into the portal. the investigators will pilot-test the portal with youth to ensure it can be implemented effectively and will be clinically beneficial. the investigators will recruit 100 youth with cp to use the portal for 2 months and see how they interact with the features and if it helps to improve their pain and mental health. the investigators will include a mixture of youth who represent different ages, sexes, genders, sexual orientations, races, dwellings, and school/employment status.


Eligibility criteria:
inclusion criteria: * experience chronic pain * speak and read english * access to internet / smartphone (or will be loaned study phone with data plan) * intend to use the portal for 2 months exclusion criteria: * youth self-reports: * receiving tertiary care or are on waitlists for tertiary care paediatric chronic pain programs * have moderate to severe cognitive impairment that may impact their ability to understand and use the power over pain portal or complete self-reported outcomes * have untreated major psychiatric illness (e.g., anorexia, psychosis) and/or active suicidality at the time of screening
nurse led transitional care model in cardiac surgery

Conditions: Nursing Care; Quality of Life; Transitional Care

Summary: to evaluate the effectiveness of nurse led transitional care model (tcm) on the functional autonomy, quality of life and rehospitalization rates of elderly patients undergoing open heart surgery.

rate and number of successful cases in open heart surgery has been increasing due to the advances in medical technology and surgery. to improve patient convalescence results and reduce rate of post-discharge readmission to hospital and unplanned post-discharge rehospitalization, home-care and follow-up process of patients should be managed successfully. a total of 66 elderly patients who agreed to participate in the study between november 2017 and december 2018 were randomly assigned to the intervention (n: 33) and control (n: 33) groups. patients in intervention group were given care based on the tcm until the post discharge 9th week starting from date of hospitalization. patients in control group were given standard care services. functional autonomy and quality of life levels of patients were evaluated at admission to the clinic and at the post-discharge 9th week whereas their repeated admission rates to the clinic and re-hospitalization rates were evaluated at post discharge 2nd, 6th and 9th weeks and finally 6 months. the consort checklist was used to check the procedure.

Eligibility criteria:
inclusion criteria: * be hospitalized for the first time and for elective open heart surgery; * have no other surgical intervention other than an open heart surgery, * have no psychological and mental disorders, * have no major chronic problems such as kidney problems, neurological problems or cancer, * be able to speak turkish, * be available to be communicated by phone, * provide consent to participate in the study, * live at a maximum distance of 50 km from the hospital (for easy access during post-discharge follow-up visits). exclusion criteria: * ask to leave the study, * be exposed to a disease or trauma that may affect his/her functional autonomy during the study, * die throughout the study

Keywords: transitional care model heart surgery nursing care autonomy quality of life elderly
inst 1204: pik3ca mutations as biomarkers for metastasis in colon cancer

Conditions: Colon Cancer

Summary: this proposal seeks to further understand the contribution of the pik3ca mutations in colon cancer, by correlating the type of hotspot mutation with the development of metastases in stage ii and stage ill patients. in order to do this, dna will be extracted from either frozen or paraffin embedded colon cancer tissues to sequence pik3ca, kras and braf. clinical outcome data will be gathered to include metastases and survival to correlate with pik3ca, kras and braf mutational status. patients with stage ii and stage ill colon cancers will be identified in the university of new mexico human tissue repository and the nih plco prevention trial biorepository. existing banked tissues of stage ii and ill colon cancers will be collected. there will be no direct contact with living individuals. epidemiological factors such as age, race, gender and outcome data of metastases and survival will be collected.

this proposal aims to identify pik3ca mutations as a biomarker for metastasis. in order to do this, dna will be extracted from either frozen or paraffin embedded colon cancer tissues to sequence pik3ca, kras and braf. clinical outcome data will be gathered to include metastases and survival to correlate with pik3ca, kras and braf mutational status. patients with stage ii and stage ill colon cancers will be identified in the university of new mexico human tissue repository and the nih plco prevention trial biorepository. existing banked tissues of stage ii and ill colon cancers will be collected. there will be no direct contact with living individuals. epidemiological factors such as age, race, gender and outcome data of metastases and survival will be collected. specific aims: 1. to develop and standardize methods for high throughput dna extraction and analysis from colon tumors of patients with stage ii and stage iii disease harboring pik3ca exon 9 and exon 20 mutations. 2. to determine the correlation between wild type and pik3ca, pik3ca exon 9 and pik3ca exon 20 mutations and development of metastatic disease and overall survival in stage ii and stage iii patients with colorectal cancer.

Eligibility criteria:
inclusion criteria: * specimen from patients with stage ii and stage iii colon cancer. exclusion criteria: * any other stage or type of disease outside of stage ii and stage iii colon cancer.
assessment of oxidative stress markers in the upper and lower airways of atopic children treated with nebulized beclomethasone

Conditions: Asthma; Allergic Rhinitis

Summary: although it is well known that the presence of uncontrolled inflammation in upper airways may compromise the control of asthma and may favor the progression of asthma toward more severe grades of disease, few studies addressed whether therapies aimed to control both upper and lower airway inflammation may be more effective in controlling asthma. markers of oxidative stress and of inflammation such as nitrotyrosine and il-5 are increased in the airways of children with atopic asthma and correlated with the levels of oral and nasal feno, and with the grade of atopy. we hypothesize that the treatment with beclometasone nebulized with a facial mask (for treating both upper and lower airways) will be able to reduce the production of oxidants as well as of il5 in both districts thus promoting clinical and functional improvements in mild intermittent asthmatic children. the results provided by this study will contribute to further clarify the relationship between nasal and bronchial inflammation.


Eligibility criteria:
inclusion criteria: * children with intermittent asthma and allergic rhinitis exclusion criteria: * children with acute respiratory symptoms in the last 4 weeks * children with nasal polyposis or bronchial or respiratory tract infections * children with a severe exacerbation of asthma resulting in hospitalization during the last month
corona virus disease 2019 patients whose nucleic acids changed from negative to positive

Conditions: COVID-19

Summary: to investigate the mechanism, clinical outcome and therapeutic efficacy with favipiravir of corona virus disease 2019 patients whose nucleic acids changed from negative to positive.

in clinical institutions that enroll corona virus disease 2019 patients whose nucleic acids changed from negative to positive, two arms, multi-center, randomized and controlled methods are adopted. patients are divided into two groups, favipiravir group and regular treatment group. 210 patients are expected to be enrolled and the cases are allocated according to the ratio of 2( favipiravir group): 1(regular treatment group).

Eligibility criteria:
inclusion criteria: 1. covid-19 has been diagnosed, and the nucleic acid test of respiratory specimens such as sputum or nasopharyngeal swabs has been negative for two consecutive times after treatment (sampling time interval of at least 24 hours); 2. the nucleic acid test of specimens such as sputum, throat swabs, blood, feces and other specimens was positive for covid-19 during screening visits; 3. voluntarily participate in research and sign informed consent. exclusion criteria: 1. those allergic to fapilavir; 2. pregnant or lactating women; 3. unstable liver, kidney, and heart diseases; 4. history of mental disorders, substance abuse or dependence; 5. researchers consider it inappropriate to participate in research; 6. participating in other clinical research.

Keywords: favipiravir