Kornimate/medical-research-clean huggingface dataset:
fecal calprotectin levels in patients with fibromyalgia

Conditions: Fibromyalgia; Irritable Bowel Syndrome; Abdominal Pain

Summary: this study was designed to evaluate fecal calprotectin levels in patients with fibromyalgia syndrome. fecal calprotectin levels from fibromyalgia patients with and without gastrointestinal symptoms as well as healthy controls will be measured and compared.

fecal calprotectin (fc) is a calcium and zinc binding protein that is present in neutrophil granulocytes and is detected in the stool samples from subjects with inflammatory bowel disease and similar organic gastrointestinal pathologies. fibromyalgia is often accompanied by irritable bowel syndrome, which is a non-inflammatory, functional disorder of the gastrointestinal tract. due to the chronic nature of the disease, fibromyalgia patients' new symptoms related to underlying gastrointestinal organic disease may be overlooked. in this study we aimed to assess the fc levels in fibromyalgia patients and healthy controls in order to detect a possible difference in fc levels between patients with and without gastrointestinal symptoms.

Eligibility criteria:
inclusion criteria: * groups 1 and 2: patients diagnosed as having fibromyalgia syndrome according to american college of rheumatology 2016 classification criteria (8). group 3 will consist of healthy controls * older than 18 years of age exclusion criteria: * presence of gastrointestinal symptoms starting after the age of 50. * presence of inflammatory rheumatological disorder * presence of organic gastrointestinal disorder * history of fever, infective gastroenteritis, endoscopy or colonoscopy in the previous month * family history of inflammatory bowel disease * patients with alarm symptoms that required further investigation such as weight loss, nocturnal diarrhea, rectal bleeding * illiteracy

Keywords: fecal calprotectin fibromyalgia irritable bowel syndrome abdominal pain
behavioural therapy with checklist for overactive bladder

Conditions: Overactive Bladder

Summary: the aim of this study is to investigate the efficiency of this newly-established checklist for overactive bladder (oab) and whether determinate to adherence and persistence rate of combination of behavioural therapy and anticholinergic medications in patients with oab.

overactive bladder (oab) can worsen quality of life but it is not life-threatening condition. although oab medications effectively decrease disturbing symptoms of oab, there are a lot of adverse side effects such as dry mouth, cognitive changes, constipation, urinary retention, blurred vision and dyspepsia. therefore, guidelines have firstly recommended behavioural therapy which are noninvasive and not linked with adverse side effects. these behavioural recommendations include an advice on fluid balance, bladder retraining, urgency suppression or normal voiding techniques, pelvic floor muscle training, caffeine reduction, dietary changes, weight loss and other life style changes to improve lower urinary tract symptoms of oab. educational leaflets, verbal or audio-visual instructions and trainings for behavioural therapy have been recommended for patients with oab, however, to date these beneficial instructions have not been documented as a written checklist. therefore, they were collected and developed as a written checklist to instruct the patients. the aim of this study was to investigate the efficiency of this newly-established checklist for oab and whether determinate to adherence and persistence rate of combination of behavioural therapy and anticholinergic medications in patients with oab.

Eligibility criteria:
inclusion criteria: patients with * \>8 micturitions, * \>1 nocturia, * \>6 urgency or * \>3 urgency urinary incontinence episodes per 24 h according to 3-day bladder diary. exclusion criteria: * active urinary tract infection, * a maximum flow rate of 15 ml. per second or less at least 2 uroflow studies, * residual volume of 100 cc or more, * any medications for oab, benign prostatic obstruction, * polyuria (\>3 l per 24 hour), * endocrinological disease such as diabetes mellitus or diabetes insipidus which can cause polyuria, * neurological or psychological disease disease, * prostate or bladder cancer, renal disease, hypertension, genitourinary or congenital abnormality, * history of transobturator or transvaginal tape or pelvic organ prolapse surgery * pelvic radiation or surgery

Keywords: overactive bladder behavioural therapy adherence drug persistence
hemoglobin measured by "orsense nbm-200mp" device and laboratory measurement

Conditions: Emergency

Summary: the purpose of this study is to compare the hemoglobin results obtained with the "orsense nbm-200mp" device and the clinical laboratory.


Eligibility criteria:
inclusion criteria: * emergency unit patients requiring an hemoglobin determination exclusion criteria: * none
pediatric boot camp program

Conditions: Type 1 Diabetes; Children, Only

Summary: an intensive 13 weeks program that aims to improve glucose control in children with type 1 diabetes.

our new pedi-boca program aims to help children with type 1 diabetes achieve better diabetes control by interacting weekly with their doctor/nurse practitioner (np) and also by using a "smart pen" that can facilitate the burden of daily calculations with the use of an app on the phone. your child's doctor/np will be able to remotely monitor your child's glucose every week (dexcom) and make recommendations for changes, discuss solutions to possible obstacles and offer intensive diabetes education.

Eligibility criteria:
inclusion criteria: 1. age 11-18 years old 2. hba1c \> 8.5% 3. duration of type 1 diabetes \>1 year 4. child uses dexcom and has a phone that is compatible with the inpen app and dexcom clarity app. exclusion criteria: not able to attend telehealth visits
functional and neurochemical brain changes in first-episode bipolar mania

Conditions: Bipolar Disorder

Summary: the purpose of this study is to use magnetic resonance imaging (mri) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium. both of these medicines are fda-approved to treat mania in adults and lithium is also fda approved in children; quetiapine is commonly used in children with mania, but is not fda approved for this indication in this age group.


Eligibility criteria:
inclusion criteria - first-episode manic bipolar patients (n=100; 15-20 patients/year): 1. patients meet dsm-iv criteria for type i bipolar disorder, manic or mixed. 2. patients have an index young mania rating scale (ymrs)70 total score \>20. 3. patients have \<3 months of lifetime anti-manic or anti-depressant medication exposure, including no active psychotropic medication in the one weeks prior to the index admission. importantly, patients will not be taken off medications for this study; this criterion is to exclude subjects receiving active treatment at the time of admission to support the 'first-episode' criterion. 4. patients have no more than two prior episodes of major depression. 5. patients are between 12 and 35 years old; subjects \< 18 yrs old have a tanner greater than or equal to 4 exclusion criteria: all subjects will be excluded from participation for the following reasons. 1. any chemical use disorder within 3 months. 2. any medical or neurological disorder that could influence fmri and mrs results. 3. a history of mental retardation or an estimated iq total score \<85. 4. an mri scan is contraindicated in the subject. 5. the patient cannot attend follow-up visits. 6. a positive urine pregnancy test (in women).
vitamin d supplementarion in pregnant women at risk and covid-19

Conditions: Pregnancy Complications; Covid19

Summary: vitamin d defiency during pregnancy is a major public health problem worldwide; in spain, the average intake of vitamin d is lower than recommendations in an elevated percentage of the population, ranging from 50 to 95%, according to the spanish society of community nutrition (senc). recent research suggests that adverse pregnancy outcomes are associated to vitain d deficiency. associated comorbidities are further complicated by the sars-cov-2 pandemic. few studies have assessed the transmission of sars-cov-2 antibodies from mothers who have had the disease or have been vaccinated to their newborns, either at birth or during breastfeeding, or how vitamin d concentration influences the generation of such an immune response. the covid-19 pandemic is a dynamic situation. peer-reviewed studies in large study cohorts point to a clear relationship between prevalence and severity of covid-19 and vitamin d deficiency.

researchers propose a randomized, non-blinded clinical trial in pregnant women recruited at the obstetrics and gynecology service of the virgen de las nieves university hospital granada during the appointment of the first gynecological control visit (weeks 10-16 of pregnancy). the woman participating in the study will be assigned to two randomized follow-up groups, intervention group that will be supplied with 1.000 iu of vitamin d and control group with 400 iu of vitamin d.all pregnant women who want to participate in the study but do not wish to supplement, will be part of another group, the unsupplemented control group. participants will take the supplementation from 10-16 weeks of gestation to delivery. the frequency of gybecological visits will coincide with their routine prenatal visits: weeks 10-16, weeks 20-24 and weeks 34-36 of gestation. during the entire duration of the study, pregnant women will be in touch with the health professionals through routine hospital controls. the present study was approved by the ethics commitee ceim/cei of granada, spain.

Eligibility criteria:
* inclusion criteria: * pregnant women * over 18 years of age. * attendance at the hospital complex and intending to give birth in public centres in the province of granada. * with the capacity to understand and sign the informed consent form. * exclusion criteria: * consumers of vitamin complexes. * co-infection with other infectious viruses or bacteria (hcv, hbv, hiv, among others). * severe respiratory symptoms that prevent participation in the study.

Keywords: pregnancy outcomes offspring supplementation vitamin d covid19 sars-cov-2
chronic disease mobile educational experience

Conditions: Chronic Disease; Heart Failure

Summary: this study evaluates the effectiveness of a mobile health education module, in increasing hospitalized patients' understanding of their chronic illness, and in reducing 30-day hospital readmission rates. half of the participants will receive the educational module intervention in addition to standard education, the other half will receive hospital standard practice education only.

chronic disease is the leading cause of death and disability, costing the us healthcare system 1 trillion dollars annually. successful management of these conditions critically requires patient understanding and engagement. patients are advised to adhere to medications, redesign lifestyles, and navigate the health care system. most of these care plan items require careful instruction and confirmation of shared understanding. mobile health technology has the potential to assist greatly with patient education, especially for hospitalized patients. this prospective study evaluates a specific mobile technology intervention, an educational and emotionally-engaging video patients watch while admitted for a complication related to one of these chronic diseases: heart failure, diabetes, copd, asthma, cirrhosis, atrial fibrillation, hypertension.

Eligibility criteria:
inclusion criteria: * admission to medical service primary team for decompensation or complication of chronic disease.(e.g. heart failure) exclusion criteria: * cognitive disability or visual/auditory limitation that prevents self-interaction with educational module
evaluation protocol of the installation of knee unicompartmental prosthesis (journey (smith & nephew)) with mechanical ancillary versus robotic assisted (navio system).

Conditions: Osteoarthritis Of Knee

Summary: unicompartmental knee arthroplasty by unicompartmental prosthesis (puc) is a treatment for isolated internal femoro-tibial osteoarthritis. this intervention is justified in cases of significant discomfort, failure of medical treatment and the absence of osteoarthritis in femoro tibial external and patellofemoral femoro compartments. it aims to replace the native internal femoral tibial articulation by a joint between two implants, without intervening on the other compartments. the functional results of puc are superior and faster than those obtained with total knee arthroplasty (tka). its indications and its realization are on the other hand very demanding to allow an optimal functional result. robotic-assisted surgery provides an excellent level of precision, which could allow better positioning of implants, compared to the use of a mechanical ancillary, according to the first published studies. the functional results and survival of these implants could also be improved. the internal puc with mechanical ancillary is carried out for many years in the orthopedic surgery department of croix rousse. for 3 years this surgery is sometimes performed with robotic assistance. the investigators would like to prospectively evaluate the clinical and radiological impact of robotic-assisted surgery when performing a journey unicompartmental prosthesis (smith \& nephew). the assessment of alignment during walking seems to be a paramount parameter in the results of the puc and has not so far been evaluated in this type of robotic-assisted surgery.


Eligibility criteria:
inclusion criteria: * male or female adult (age ≥ 18 years) * diagnosis of unicompartmental knee osteoarthritis ( osteoarthritis internal femoral tibial (afti)) * indication of unicompartmental knee arthroplasty of first intention posed exclusion criteria: * history of femoral or tibial osteotomy of valgization or varisation * reconstruction of the associated cruciate ligament * refusal to participate in the study * pregnant women, parturient or nursing mothers * persons deprived of their liberty by a judicial decision or administrative staff, persons under psychiatric care, persons admitted to a health or social institution to other purposes. * major persons subject to a legal protection measure or unable to express their consent * patient not affiliated to a social security scheme * patient participating in another interventional research excluding routine care research (former regulation) and category 2 searches not interfering with criterion analysis main

Keywords: knee unicompartmental prosthesis kneekg system robotic-assisted alignment implants positioning international knee society forgotten joint score
the impact of scn9a gene polymorphism on individual pain perception in the general population

Conditions: Pain; Surgery

Summary: this study was conducted to explore whether the non-synonymous single-nucleotide polymorphisms in scn9a gene can predict individual basal pain perception and postoperative pain intensity in the general population undergoing upper abdominal surgery. methods: patients receiving elective upper abdominal surgery under general anesthesia were recruited into this study. genotyping of scn9a was carried out by direct sequencing. the investigators measured their preoperative pressure pain threshold (ppt) and pressure pain tolerance (pto). the visual analog scale (vas) was used for pain evaluation at rest during patient-controlled analgesia (pca) treatment 0 h, 12 h ,24 h and 48h after operation. and the pca press frequency and drug consumption were recorded.

patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.

Eligibility criteria:
inclusion criteria: * aged 20-70 years * receiving elective upper abdominal surgery * anesthesiologists (asa) physical status i or ii * received pca administration * agreed to participate the research exclusion criteria: * history of chronic pain * psychiatric diseases * diabetes mellitus * severe cardiovascular diseases * kidney or liver diseases * alcohol or drug abuse * heavy smoker * pregnancy or at lactation period * refused pca administration * disagree to participate to the research

Keywords: gene polymorphism scn9a pain perception postoperative pain
oral cell dna adducts in smokers

Conditions: Lung Cancer

Summary: dna adducts in the oral mucosa cells of 100 smokers from 3 ethnic groups - native hawaiians, whites, and japanese americans with differing risks for lung cancer upon cigarette smoking will be quantified. dna adducts of tobacco smoke carcinogens will be quantified using both targeted and untargeted approaches.

using high resolution mass spectrometry, quantify known dna adducts in oral mucosa cells of 100 smokers from each ethnic group - native hawaiians, whites, and japanese americans. dna adducts of tobacco-specific compounds, formaldehyde, and acrolein will be quantified. 2. analyze the urine of 100 smokers and 100 non-smokers from each of these groups for mercapturic acids of acrolein and crotonaldehyde, as well as total nicotine equivalents and total nnal (smokers only). these data will provide critical information relevant to the high risk of native hawaiians for lung cancer, and in relationship to the dna adduct measurements of specific aim 1.

Eligibility criteria:
inclusion criteria: * currently smoke at least 5 cigarettes per day, self-identified japanese americans, european americans, or native hawaiians. exclusion criteria: * no current use of other nicotine containing products, no acute or uncontrolled medical or psychiatric conditions, no greater than 14 alcoholic drinks per week, not pregnant, not breastfeeding, not currently taking any medications that affect relevant metabolic enzymes, no active infection.
delivery method and risk for urogenital prolapse 15-20 years later

Conditions: Uterine Prolapse; Urinary Incontinence; Fecal Incontinence

Summary: the lifetime risk for a woman to undergo surgery for either vaginal prolapse or urinary incontinence is high. previous studies have shown that pregnancy and childbirth are risk factors for developing prolapse. there is a lack of studies that follow women several years after delivery aiming to find whether symptoms of prolapse are linked to delivery method, ie vacuum, forceps, normal vaginal delivery and cesarean section. the investigators plan this study is to get more knowledge about pathology of prolapse and incontinence, to enable development of preventive strategies for these conditions. aim of the study is to determine whether the prevalence of symptoms and performed surgery for urogenital prolapse differs among women delivered by vacuum, forceps, normal vaginal delivery and cesarean section 15-20 years after their first delivery. the investigators identify women that delivered their first child at st. olavs hospital, trondheim, norway between 1990-1997. questionnaires will be sent to 2500 women (pfiq-7, pfdi-20, pisq-12), 600 of whom will get a clinical examination, where pelvic floor musculature is examined by palpation and 4d ultrasound, and a pop-q quantification of prolapse performed.


Eligibility criteria:
inclusion criteria: * first delivery in time period 1990-1997 * vaginal birth, spontaneous, forceps or vacuum extraction, or cesarean section * residency in klæbu, malvik, melhus, midtre gauldal, rissa, selbu, trondheim, tydal, åfjord at the time of first delivery exclusion criteria: * stillbirth * breech birth * congenital abnormalities * residency outside the 9 selected communities * forceps delivery following previous vacuum extraction delivery or spontaneous vaginal birth * vacuum extraction delivery following previous forceps delivery or spontaneous vaginal birth * vaginal birth following previous cesarean section

Keywords: delivery, obstetric obstetric surgical procedures vacuum extraction, obstetrical cesarean section obstetrical forceps epidemiology norway
covid-19 testing in patients with vascular disorders

Conditions: Covid19

Summary: background: to investigate the prevalence of sars-cov-2 infection in hospitalized patients with vascular disorders after implementing institutional and governmental safety measures. materials and methods: vascular patients (vps) admitted to our tertiary care hospital were routinely tested for sars-cov-2 infection on a two days basis between march and december, 2020. the prevalence of sars-cov-2 was compared between vps and two independent austrian populations (april and november 2020) tested by the austrian ministry of science. the results were also compared to a cohort of health care personnel (hcp) working in close proximity to the study patients, tested weekly, between march and december, 2020. rt-pcr and antigen test were used to detect sars-cov-2.


Eligibility criteria:
inclusion criteria: all inpatient admissions exclusion criteria: outpatient admissions
evaluation of elx/tez/iva in cystic fibrosis (cf) subjects 2 through 5 years

Conditions: Cystic Fibrosis

Summary: this study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of elexacaftor (elx)/tezacaftor (tez)/ivacaftor (iva) triple combination therapy in cf subjects 2 through 5 years of age.


Eligibility criteria:
key inclusion criteria: * homozygous for the f508del mutation or heterozygous for f508del and a minimal function (mf) mutation (f/f or f/mf genotypes) key exclusion criteria: * clinically significant cirrhosis with or without portal hypertension * lung infection with organisms associated with a more rapid decline in pulmonary status * solid organ or hematological transplantation other protocol defined inclusion/exclusion criteria may apply
listen to a audio book

Conditions: Respiratory Failure With Hypercapnia

Summary: this study investigates how listening to audiobooks affects agitation scores and respiratory parameters (like breathing rate, depth, and oxygen saturation) in patients receiving non-invasive mechanical ventilation (nimv) for hypercapnic respiratory failure in an intensive care unit. participants will listen to an audiobook of their choice during their 2-hour nimv treatment. their agitation levels and respiratory parameters will be measured before, during, and after nimv application. the goal is to evaluate whether audiobooks can reduce patient agitation and improve respiratory outcomes, offering a low-cost, easy-to-use, and effective approach for better patient care.


Eligibility criteria:
inclusion criteria: patients aged 18 years or older patients hospitalized in the chest diseases intensive care unit diagnosed with hypercapnic respiratory failure undergoing non-invasive mechanical ventilation (nimv) no hearing impairment conscious and alert patients exclusion criteria: patients unwilling to participate or wishing to withdraw from the study