Kornimate/medical-research-clean huggingface dataset:
utility of crocsrx clog as a diabetic house shoe: a pilot study

Conditions: Diabetes

Summary: foot complications are a common and costly problem for subjects with diabetes. although medicare provides a pair of diabetic shoes yearly for subjects with diabetes, many do not wear their diabetic shoes in and around their house. instead, subjects may wear shoes, such as flip flops or slippers, that provide little to no protection against injuries. while proper house shoe is important in the prevention of diabetic foot complications, this area has not received much attention. the purpose of this pilot study is to assess if crocsrx medical silver cloud clogs - a lightweight clog with protective toe box, cushioning soles, and easy to don and doff - offer reduced dynamic plantar pressure magnitude, as compared to conventional house shoes, for subjects with diabetes. a repeated measures anova study design will be used to assess dynamic plantar pressure in 2 shod conditions for each subject with the order of shoes randomized.


Eligibility criteria:
inclusion criteria: * male or female between the ages of 21 and 75 (inclusive) * documented type 1 or type 2 diabetes mellitus * demonstrated abnormal foot biomechanics by the presence of intractable plantar keratoma (ipk) beneath metatarsal heads or hallux * participants with and without signs of peripheral neuropathy (unable to perceive a 10 gram monofilament or vibration perception threshold (vpt \> 25 volts) * able to walk independently without the use of walking aids (cane, crutches, or walker) * able to speak and understand english * able to understand the information in the consent form and willing and able to sign the consent form exclusion criteria: * history of lower limb amputations (excluding toe amputations) * presence of cutaneous ulceration in the lower extremity * history of or active charcot neuroarthropathy of either foot * severe peripheral vascular disease (i.e. ischemic rest pain, 2-block claudication, or gangrene) * end stage kidney disease requiring hemodialysis, stroke, or widespread malignant disease * pregnant or nursing * not willing or able to make the required follow-up visits * insufficient (corrected) vision to complete the questionnaire * unable to fit into available shoe sizes

Keywords: diabetes foot complications plantar keratoma plantar pressure
frailty walking patterns (frap) study

Conditions: Heart Failure

Summary: the aim of this study is to evaluate sit-stand phases and gait speed detection using an externally worn reveal linq (tm) compared to an external reference (3d accelerometer, and/or the computer assisted rehabilitation environment (caren) system) in one center in the netherlands

frailty is a geriatric syndrome characterized by reduced homeostatic reserves, exposing the organism to extreme vulnerability to endogenous and exogenous stressors. frailty is prevalent in older people and involves a progressive physiological decline of multiple body systems, typical signs and symptoms include weight loss, fatigue, muscle weakness, slow or unsteady gait declines in activity. frailty is increasingly recognized as an important prognostic indicator in heart failure (hf) and is more prevalent in hf than the general population. the identification of frailty in its early stage is important because interventions may potentially prevent, or delay the clinical consequences of frailty. of particular focus in this study will be walking speed as prior research has demonstrated that slow gait speed has the strongest prognostic ability of the traditional components used to assess frailty, and has been reported as one of the strongest to predict adverse outcomes, such as mobility disability, falls, or hospitalization. also of interest is the detection of posture changes as this may have implications for detecting changes in sleeping habits and could also provide context for other biomarker signals collected by the linq device. the literature has been reviewed and the scientific soundness of the proposed analytical techniques evaluated. the rationale for this study design is to evaluate the feasibility of using the reveal linq™ to monitoring walking patterns. hf patients (the target population for the study in discussion) would make it possible to test the sensitivity of the accelerometer embedded in the linq device in a small cohort of subjects with reduced mobility and for which frailty is more prevalent than the general population, as well as recognized as an important prognostic indicator. no risk to the subjects is expected with this study.

Eligibility criteria:
inclusion criteria: * chronic heart failure in new york heart association (nhya) class ii and class iii * willing to sign the informed consent form. * at least 18 years of age. exclusion criteria: * • not able to walk continuously for a period of 6 minutes and perform the walking exercises as necessary for the study protocol. * any known allergy to titanium * any concomitant conditions which in the opinion of the investigator would not allow accurate measurement of gait and frailty parameters with an externally worn device. * any concomitant condition which in the opinion of the investigator would not allow a safe participation in the study. * enrolled in another study that could confound the results of this study, without documented pre-approval from a medtronic study manager.
massed and spaced hmp app dosage study

Conditions: Depression, Anxiety; Psychological Distress; Loneliness

Summary: this study is a randomized controlled trial (rct) of 2 weeks of the healthy minds program (hmp) app connection module in undergraduate students of a large, midwestern state university in the united states during the spring of 2021. participants will be recruited via email and/or flyers and will first complete an online screen. eligible participants will complete baseline measures prior to attending an introductory session via web conferencing. during this session, participants will be randomly assigned to condition. participants in both conditions will be asked to use the hmp app for 20 minutes per either, either split over two 10-minute session (spaced condition) or in one 20-minute session (massed condition). participants will complete daily survey measures during the study and post-test measures after 2 weeks of intervention. this study is primarily designed to assess feasibility and acceptability of 2 weeks of connection training and assignment to dosage condition. study team will investigate self-reported informal practice on the daily diary measure, measures of psychological distress (composite of depression, anxiety) and loneliness.


Eligibility criteria:
inclusion criteria: * 18 years or older * undergraduate at uw-madison * access to a smartphone or device capable of downloading hmp app * promis depression or promis anxiety ≥55 exclusion criteria: * meditation retreat experience * regular meditation practice (i.e., weekly practice for \>1 year or daily practice within previous 6 months) * previous practice under the instruction of a meditation teacher, other than in the context of an introductory course * promis depression ≥70
antimicrobial photodynamic therapy associated with the conventional endodontic treatment: a clinical and microbiological study

Conditions: Photochemotherapy Reaction; Dental Pulp Necrosis; Polymerase Chain Reaction; Infection; Enterococcal Infections; Candida

Summary: microorganisms play a critical role in the etiology and pathogenesis of apical periodontitis. enterococcus faecalis and candida sp. are frequently associated with persistent infections. the aim of this study was evaluated the antimicrobial photodynamic therapy (apdt) as an adjunct of the endodontic treatment. ten uniradicular teeth \[control group (cg)=4 and test group (tg)=6\] with primary endodontic infections were analyzed. microbiological samples were collected before and after the chemical-mechanical instrumentation (cmi), after the apdt (for the tg) and after the temporary restorations removal (second session).


Eligibility criteria:
inclusion criteria: * patients with teeth with: single canal with endodontic infection, intact pulp chamber walls, necrotic pulp confirmed by sensitivity pulp tests, and clinical and radiographic evidence of asymptomatic apical periodontitis exclusion criteria: * patients with teeth with: gross carious lesions, root or crown fracture, previous endodontic treatment, gingival recession and periodontal pockets deeper than 4 mm. * patients pregnant, lactating, with systemic diseases that could compromise the immune system, individuals who received antibiotic therapy within the previous 3 months or in immunosuppressive treatment.
comparing the effect of focused and radial extracorporeal shock waves on post-stroke hypertonia

Conditions: Spasticity

Summary: the main purpose of this study is to compare treatment efficacy of focused and radial extracorporeal shock waves on spasticity in chronic stroke patient

this study is a prospective and double-blinded randomized control trial. thirty-two stroke patients with spastic equinus were randomly assigned to receive three sessions of either focused shockwave therapy or radial shockwave therapy at 1-week intervals. the intensities that were used during fswt (0.1 mj/mm2) and rswt (2 bar) were comparable. patients were evaluated at baseline and at 1, 4, 8 weeks after the final shockwave treatment. the primary outcome measure was modified ashworth scale (mas) score. secondary outcome measures were tardieu scale, ankle passive range of motion, plantar contact area during gait, and gait speed. a linear mixed model with repeated measures was used to compare each outcome measure between the two groups.

Eligibility criteria:
inclusion criteria: * aged greater than 18 years old; * at least 6 months since onset of last stroke; * triceps surae muscle tone graded at least 1+ on the modified ashworth scale (mas) score; * ability to walk alone with/without orthosis. exclusion criteria: * exclusion criteria included fixed ankle joint contracture, previous treatment of the affected leg with neurolytic or surgical procedures, concomitant progressive central nervous system diseases, and skin breakdown, vascular disease in the affected leg
unnecessary mastectomy due to false size prediction by preoperative imaging studies in breast cancer

Conditions: Breast Cancer; Surgery; IMAGE; Chemotherapy Effect

Summary: * the surgical method for breast cancer is determined according to the size and location of the remaining lesions after prior chemotherapy. * there are many patients who were able to undergo partial resection when confirming the final results of patients who underwent total resection after prior chemotherapy. * therefore, we would like to investigate whether it is effective to make decisions based on the results of pre-operative tests after prior chemotherapy.

in a study published by jennifer f. et al., sensitivity to lesions remaining after prior chemotherapy of breast magnetic resonance imaging was measured as 83%, specificity 47%, ppv 47%, npv 83%, and accuracy 74%. have. most of the preoperative examinations after prior chemotherapy have the most confidence in the results of breast magnetic resonance imaging, but there will be other factors to predict this result as there will be differences in the actual postoperative pathology results. . after prior chemotherapy, total resection was performed, and cases where partial resection is possible in the postoperative pathologic results are prospectively identified and compared and analyzed.

Eligibility criteria:
inclusion criteria: * breast cancer patients over 20 years of age undergoing surgery at seoul national university hospital * patients to undergo total mastectomy * patients who received neoadjuvant chemotherapy and undergoing total mastectomy were the main subjects, but as a control group, patients who did not receive neoadjuvant chemotherapy but undergoing total mastectomy were included as subjects. exclusion criteria: * in case of total mastectomy at the request of the patient * except for cases where total resection is performed regardless of size because it is a lesion under the areola and is close to the nipple.
onlay vs. inlay patellofemoral arthroplasty

Conditions: Patellofemoral Joint; Osteoarthritis

Summary: there is currently no sufficient evidence if there is superiority of one of the two available types (onlay type, inlay type) of patellofemoral arthroplasty. therefore, it is the aim of this study to compare the two types in a prospective comparative setting. patients on the waiting list for patellofemoral arthroplasty are randomized to either onlay or inlay type patellofemoral arthroplasty. the koos - knee score serves as the primary outcome parameter. secondary outcome parameters are the marx activity scale, the hss patella score, the kujala score, radiographic loosening, progression of tibiofemoral degeneration, revision surgery and parameters of patellofemoral tracking. inferential statistics will be performed at 1-year follow up data-sets.


Eligibility criteria:
inclusion criteria: * patellofemoral osteoarthritis, waiting list for patellofemoral arthroplasty exclusion criteria: * systemic inflammatory arthropathy * tibiofemoral joint degeneration ikdc grade c or worse * severe degeneration of also the trochlea margins (inlay pfa not adequate) * patellectomy * previous implantation of tibiofemoral metal implants * extension loss \>5 degree * knee flexion of less than 100° * planned concomitant tibiofemoral procedures (eg. coronal plane osteotomies, tibiofemoral cartilage procedures, tibiofemoral ligament procedures)
device feasibility and acceptability to improve insomnia in cancer

Conditions: Cancer; Insomnia Chronic

Summary: sleep disruption is common among young adult cancer survivors for a variety of reasons. cognitive behavioral therapy for insomnia (cbt-i) has been shown to improve chronic sleep disorders. this project will test the feasibility and acceptability of a new voice-activated virtual assistant (vava) device to deliver cbt-i to improve sleep among young adult cancer survivors with chronic sleep disorders.

sleep is a complex biobehavioral event, impacted by interactions between the individual's physiology as well as their environment. young adult cancer survivors (yacs; those between 18- 29 years of age) are a growing group of survivors, numbering close to 400,000 in the us. they are among those at highest risk for chronically insufficient sleep due to developmentally normative biological and social factors, compounded by their extensive medical treatment history. cognitive-behavioral therapy for insomnia (cbt-i) is recommended by the american college of physicians as gold standard treatment for insomnia disorder and has been successfully adapted for yacs. fundamental cbt-i strategies can be implemented to change the problematic sleep behaviors that result in insufficient sleep among young adults. however, it is essential that these evidence-based strategies be deployed to be responsive to the specific barriers to sleep for yacs. this feasibility/acceptability study will test the use of an integrated vava that offers the opportunity to implement intervention strategies in a way that repeatedly gives yacs the chance to make the right decision with respect to their sleep health in real time.

Eligibility criteria:
inclusion criteria: * age between 18 and 29 years old * history of cancer (any type, any stage) * chronic sleep loss as evidence by self-report of receiving less sleep than recommended for their age by the national sleep foundation for \>/= 3 months * must have an internet router in their primary home that they have access to (can add a second router to for the system to work) exclusion criteria: * acute medical/psychiatric disorder requiring treatment * developmental or congenital disorder * life expectancy \<12 months.
prognostic value of lactate levels in patients with stemi undergoing primary pci

Conditions: STEMI

Summary: to assess the prognostic value of systemic arterial lactate levels in patients with st segment elevation myocardial infarction undergoing primary pci and correlate with the results of primary pci and 30 days mace follow up.

* study population: stemi patients treated with primary pci. * study period: over 6 months. * sample size: 300 patients. all patients received the standard care for acute stemi patients which is the primary percutaneous intervention in addition to medications. hyperlactemia is defined as elevated lactic acid level in the blood. the normal blood lactate level is (0.5-1 mmol/l). all subjects were subjected to 1. careful history taking 2. full cardiac examination 3. investigations include: 1. 12 lead surface ecg. 2. lactate level and full labs 3. pre-discharge echocardiography 4. peri-procedural details of primary pci the investigators assessed the relation between hyperlactemia and coronary flow, peak cardiac enzymes, hemodynamic parameters and mace in 30 days follow up

Eligibility criteria:
inclusion criteria: * patient with st-segment elevation myocardial infarction for the first time. * patients undergoing primary pci. * adult patients ≥ 18 years old. exclusion criteria: * hemodynamically unstable patients. * patients with renal impairment (creatinine clearance \< 30 ml/min). * patients who developed flow limiting coronary dissection or mechanical complication during the procedure. * patients presenting \> 24 hours after symptoms onset.
reliability of the facial wrinkle scale in japanese subjects

Conditions: Facial Rhytides

Summary: this study will evaluate the inter-rater and intra-rater reliability of the facial wrinkle scale with asian photonumeric guide (fws-a) in japanese subjects.


Eligibility criteria:
inclusion criteria: * ability to assess facial lines in a mirror * removal of facial jewelry and makeup for study visit exclusion criteria: * infection or skin disorder affecting the face * planned use of botulinum toxin of any serotype between screening and day 1 * planned facial cosmetic procedure between screening and day 1 * planned excessive/prolonged sun exposure between screening and day 1
flexible ureteroscopy with and without ureteral access sheath in treatment of large renal stones

Conditions: Flexible Ureteroscopy; Ureteral Access Sheath; Large Renal Stones

Summary: the aim of this study is to evaluate the flexible ureteroscope (furs) technique with and without ureteral access sheath (uas).

treating a large renal stone, more than 2 cm, is changing during the last decades. technological innovations have led to a significant improvement in flexible ureteroscopes over recent years. many authors have used flexible ureteroscope (furs) with laser fragmentation as proved treating modality with high efficacy. although percutaneous extraction of large renal stones is still the first option, it has higher and more severer complications than flexible ureteroscopy. furs has developed into a standard diagnostic and treatment modality for upper urinary stone disease, transitional cell carcinoma and ureteral strictures. indeed, more recently furs is becoming a minimally invasive competitor to percutaneous nephrolithotomy for larger kidney stones as well as an accepted modality for localized treatment of small upper urinary tract transitional cell carcinoma. the use of ureteral access sheath (uas) is widely recognized as a technique utilized to keep the intrarenal pressure low when performing furs for larger and more complex stones, although some authors advocate its use for most renal stones. uass are now produced with varying characteristics including various lengths, diameters, materials, dilator tip designs, radiopaque markers, and stiffness. however, it also rises surgical costs and may injure the ureteral wall. most common reasons cited by urologists for using a uas are to facilitate repeated entrance into the ureter and collecting system (as a time-saver), lower intrarenal pressure and protection of ureteroscope and ureter when extracting stone fragments. uas has encouraged urologists in the fragmentation of large stones; it facilitates multiple entries and stone extraction during furs.

Eligibility criteria:
inclusion criteria: * age \> 18 years old. * both sexes. * patients with upper ureter and renal stones scheduled for flexible ureteroscope. exclusion criteria: * patients with associated distal ureteral stone, kidney transplant or any kind of urinary diversion. * larger stones (11 cm) where the routine use of an access sheath will be felt appropriate to aid multiple passes of the scope. * known ureteric strictures. * concomitant ureteric stones. * patients with narrow ureter where ureteral access sheath was anticipated to be difficult.
usefulness of sodium mri in the presurgical assessment of drug-resistant partial epilepsy

Conditions: Epileptic Seizures

Summary: epilepsy is a common disease affecting 0.5 to 1% of the general population. epilepsies refractory to drug treatment lead to increased morbidity, mortality and high costs for public health (representing 75% of the costs associated with epilepsy is among the most costly diseases in neurology). the only curative therapy is surgical removal or disconnection of the epileptogenic network. to do this, a comprehensive presurgical evaluation is essential to accurately define the location of the epileptogenic zone (ez) and its relationship with the functional areas that must be preserved. this approach requires in some cases intracerebral eeg recordings. this latter technique, expensive and invasive, remains at present, the standard method in the location of the ze. in this context, the development of non-invasive and inexpensive methods is a priority in the field. moreover, many fundamental studies have shown changes in ion homeostasis including sodium associated with hyperexcitability related to epilepsy. the investigators team at cemerem, chu timone, specialized in the development and validation of innovative methods in mri, has developed an in vivo sodium mri acquisition and processing of data unique in france, capable of quantifying the intracerebral sodium concentration in three dimensions in a completely non-invasive and non-irradiating manner


Eligibility criteria:
inclusion criteria: * patient presenting a drug-resistant partial epilepsy for which an indication is indicated after préchirugical balance assessment. * patient not presenting a psychiatric disease chronicles, an demential syndrome, * patient not presenting contraindication to the realization of an examination by mri exclusion criteria: * patient suffering a not operable shape of partial epilepsy or a generalized epilepsy * patient suffering an evolutionary associated serious illness (cancer, autoimmune disease, hepatic insufficiency)

Keywords: epilepsy seizures