Kornimate/medical-research-clean huggingface dataset:
healthy lifestyles: a home based physical activity intervention in persons living with hiv

Conditions: HIV-1-infection; Metabolic Syndrome

Summary: this study is being done to understand how a physical activity walking intervention affects metabolic parameters (i.e., blood sugar, cholesterol, certain body measurements) in people with and without hiv. this study involves a physical activity intervention where participants will progressively increase activity as tolerated over a six month period.

this study is being done to understand how a physical activity walking intervention affects metabolic parameters (i.e., blood sugar, cholesterol, certain body measurements) in people with and without hiv. this study involves a physical activity intervention where participants will progressively increase the total number of daily steps to approximately 10,000 steps/day as tolerated. we will monitor participant steps and physical activity using a physical activity monitor. the study will consist of 5 in-person study visits where participants will complete body measurements, laboratory testing (for metabolic parameters e.g. blood sugar and cholesterol), and a questionnaire.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * persons living with or without hiv * metabolic syndrome or risk factors for metabolic syndrome with bmi \>=30 * able to provide informed consent * no physical limitations that prevent walking for more than 10 minutes * can provide evidence of medical clearance by healthcare provider, if required before or during the study exclusion criteria: * currently exercising regularly (at least 2x weekly of at least 20minutes of moderate or vigorous activity) * current enrollment in another physician activity and/or dietary clinical trial or on diet/weight-loss program * active plans for bariatric surgery * inability to commit to the intervention schedule * not eligible as per screening form * currently pregnant or planning to become pregnant
clinical pilates in hip osteoarthritis: a randomised controlled trial

Conditions: Hip Osteoarthritis

Summary: the aim of this study is to investigate the effect of a clinical pilates exercise program on reducing symptoms in individuals with hip osteoarthritis. the main questions it aims to answer are: * does a clinical pilates exercise program have an effect on pain, range of motion, physical function, performance, spinal mobility, postural control, disability, self-efficacy, and quality of life in individuals with hip osteoarthritis? * does a conventional therapeutic exercise program have an effect on pain, range of motion, physical function, performance, spinal mobility, postural control, disability, self-efficacy, and quality of life in individuals with hip osteoarthritis? researchers will compare clinical pilates program to conventional therapeutic exercise program to see if exercise works to reducing hip osteoarthritis symptoms. participants will: * take clinical pilates or conventional therapeutic exercise twice a week for 12 weeks * the patients will be assessed by a blind evaluator both before and after the treatment.

the clinical pilates group will perform 45-minute exercise sessions under the supervision of a physiotherapist twice a week for 12 weeks, focusing on fundamental spinal alignments and pilates principles. the program will include exercises that engage all body segments and combine movement with breathing. participants will progress to more advanced levels as long as they can maintain proper alignment. clinical pilates exercises are structured into three levels of difficulty, and participants who complete the current level without compromising alignment will advance to the next level. the conventional therapeutic exercise group will participate in an exercise program under the supervision of a physiotherapist twice a week for 12 weeks. the program, consisting of stretching and strengthening exercises, will last approximately 45 minutes. resistance bands will be used to facilitate progression. based on the individual's perceived difficulty level, resistance bands will be introduced or adjusted by changing their color to increase or decrease resistance.

Eligibility criteria:
inclusion criteria: * age above 18 years * diagnosis of hip osteoarthritis (oa) according to the american college of rheumatology * not on the waiting list for hip replacement surgery * willingness to participate in the exercise program exclusion criteria: * symptomatic oa in the knee or big toe * presence of other types of arthritis * history of hip and/or knee prosthesis or fracture * use of walking aids * regular exercise habit of two or more sessions per week * corticosteroid injection into the hip within the past 12 months * participation in a physical therapy program for hip pain within the past 3 months * severe cardiovascular disorders or other comorbidities that significantly limit daily physical capacity or contraindicate physical exertion

Keywords: pilates exercise pain osteoarthritis
prognosis of very low dose spect

Conditions: Chest Pain

Summary: nuclear stress testing evaluates whether the heart receives enough blood, by injection of a nuclear isotope during a stress on the heart that permits taking pictures of the heart muscle. a low-radiation-dose protocol for nuclear stress testing involves injecting less of the nuclear isotope than standard protocols, by utilizing a new, more efficient camera (called an alcyone camera) which could decrease radiation dose to patients while still providing excellent clinical information. subjects will undergo imaging under the alcyone camera after undergoing stress testing with exercise or a standard medication simulating exercise, and then at rest if needed. subjects will have follow-up to measure events occurring after the test, such as death, heart attack, unstable angina, repeat emergency department visit for chest pain evaluation, or repeat imaging needed to evaluation for coronary artery disease. radiation doses and quality of the images from the imaging with the new protocol will be recorded to compare to those used in standard nuclear imaging protocols. the primary study hypothesis is that greater than 90% of patients who have a normal very low dose stress first myocardial perfusion scintigraphy (mps) will be free at 3 months after study of death, nonfatal myocardial infarction, unstable angina, and repeat emergency department visit for chest pain evaluation or repeat anatomical or functional cardiac imaging.

see brief summary above.

Eligibility criteria:
inclusion criteria: * patients presenting with chest pain but normal or nondiagnostic electrocardiograms and at least 3 negative troponin levels taken 4 or more hours apart. * age greater than 18 years. * written informed consent is obtained by a study investigator. exclusion criteria: * previous myocardial perfusion scintigraphy (mps) with evidence of scar * previous mps with evidence of ischemia and no subsequent revascularization * known dilated left ventricle * known cardiomyopathy * high pre-test probability of a perfusion defect on mps * body mass index greater than 35 * prisoner status

Keywords: chest pain myocardial perfusion scintigraphy nuclear stress testing low radiation dose
study to evaluate the effects of food ingestion on the pharmacokinetics of chf 5074 in healthy young male subjects

Conditions: Alzheimer's Disease

Summary: to evaluate the effects of a high-calorie high-fat meal on the extent and rate of absorption of chf 5074 after single oral administration in young healthy male volunteers.


Eligibility criteria:
inclusion criteria: * subject is judged to be in good health on the basis of medical history, complete physical examination including vital signs, 12-lead electrocardiogram (ecg) and standard laboratory tests. * subject has a body mass index between 18 and 30 kg/m\^2, inclusive. exclusion criteria: * medical history (within the last 10 years) of major cardiovascular, hepatic or renal disease. * abnormal result of liver function tests, renal function tests or thyroid tests performed at screening. * significant allergic conditions that require medical treatment * use of any psychoactive, recreational or prescription drug within the 4 weeks prior to study drug administration. * use of ibuprofen, sulindac sulfide, indomethacin, flurbiprofen within 2 weeks prior to study drug administration.
the effect of meal replacement on the time to reach the blood glucose target in patients with type 2 diabetes mellitus

Conditions: Diabetes; Blood Sugar; High

Summary: this study was designed as a randomized controlled study. it was planned to include 100 patients with type 2 diabetes who received short-term intensive insulin therapy and randomly divided them into a meal replacement intervention group and a conventional diabetes diet group according to 1:1. both groups were treated with short-term intensive insulin therapy to control blood sugar. .


Eligibility criteria:
inclusion criteria: 1. type 2 diabetic patients who meet the diagnosis of type 2 diabetes (cds2020) and are willing to receive intensive insulin hypoglycemic therapy; 2. glycated hemoglobin a1c≥7.5%; 3. age between 18-70 years old, body mass index (bmi) 20-35kg/m2; 4. be able and willing to cooperate with diet and exercise and monitor blood sugar in accordance with the project regulations, and agree to sign the informed consent. exclusion criteria: 1. diagnosed as type 1 diabetes or special type of diabetes; 2. allergic or intolerable to the meal replacement food used in the study; 3. acute complications of diabetes (including dka, hhs, lactic acidosis) 4. severe microvascular complications: proliferative retinopathy; urine aer\>300mg/g or urine protein positive, quantitative\>0.5g/d; uncontrolled painful diabetic neuropathy and significant diabetic autonomic neuropathy; 5. significant macrovascular complications: patients with acute cerebrovascular accident, acute coronary syndrome, peripheral arterial disease requiring vascular intervention or amputation within 12 months before enrollment; 6. serum creatinine clearance rate is less than 50ml/min/1.73m2 (calculated according to ckdepi formula), alanine aminotransferase ≥ 3 times the upper limit of normal, and total bilirubin ≥ 2 times the upper limit of normal; 7. the cumulative time of using drugs that may affect blood sugar for more than 1 week within 12 weeks, such as oral/intravenous glucocorticoids, gh, estrogen/progestin, high-dose diuretics, antipsychotics, etc.; 8. systemic infection or serious concomitant diseases; patients with malignant tumors or chronic diarrhea; 9. uncontrolled endocrine gland dysfunction; 10. mental or communication disorders; 11. pregnant and lactating women; 12. the subject is not cooperative, or the investigator judges that it may be difficult to complete the investigator; 13. other circumstances judged by the investigator to be unsuitable for inclusion.

Keywords: type 2 diabetes meal replacement
remote ischaemic preconditioning combined with exercise training on vascular function.

Conditions: Cardiovascular Disease Risk

Summary: remote ischaemic preconditioning' (ripc) is defined as short controlled sequences of repeated inflation of a blood pressure cuff on the upper arm (to reduce blood flow) for 5 mins followed by recovery (cuff deflation so blood flows normally again). an intervention consisting of 4 cycles of 5 min of arm cuff inflation followed by deflation performed 3 times per week, spread over 8 weeks has been shown to improve blood vessel function in young individuals without any medical conditions. this is a simple and easily applicable intervention that could help the blood vessels capacity to deliver blood to an organ (e.g. heart or the muscle).it is currently unknown if ripc combined with exercise training, provides stronger benefits to our blood vessels than ripc alone. therefore, the aim of this study is to investigate if combining ripc with an 8 week exercise training programme improves blood vessel health more than 8 weeks of ripc alone.

a bout of ischaemia using a blood pressure cuff on the upper arm inflated to a pressure of 220 mm hg for 5 mins followed by reperfusion (deflation of the cuff) is commonly known as remote ischaemic preconditioning (ripc). traditionally, ripc refers to 5 minutes of inflation-5 minutes deflation repeated 4 times. recent research has investigated the impact of repeated ripc interventions on cardiovascular health. one previous repeated ripc intervention, whereby ripc was performed 3 times per week for eight weeks, identified that ripc significantly enhanced conduit artery endothelial function and microvascular function. exercise training is crucial for a healthy lifestyle, with the world health organization recommending that adults aged 18-64 should do at least 150 minutes of moderate aerobic physical activity per week, or at least 75 minutes of vigorous intensity activity. interestingly, the impact of exercise training on the vasculature is similar to that of repeated ripc interventions, with reductions in arterial blood pressure, increased in blood flow and improvements in systemic vascular endothelial function. no study has examined if combining exercise and ripc provides enhanced effects on the vasculature compared to exercise alone. the aim of this study is to investigate whether combining 8 weeks of exercise and ripc is more beneficial to systemic vascular function that exercise alone.

Eligibility criteria:
inclusion criteria: * able to provide written consent. * males and females 18 to 65 years. * body mass index \>30g/m2 or waist circumference of ≥94cm (male), ≥80cm (female). * raised blood pressure systolic \>130 or diastolic \>85 mmhg or normal * diagnosed with high cholesterol by gp or normal exclusion criteria: * type 1 or 2 diabetes mellitus * previous myocardial infarction, stroke (including tia) or thrombosis * diagnosed with congestive heart failure * unable to enroll for the duration of the study * pregnancy or lactation period * smoking * any arm injury that will prevent application of the ripc-intervention
thrombo embolic events in critical care patients with covid-19 serious acute pneumopathy

Conditions: COVID-19; Pneumonia; ARDS; Hemostasis; Coagulation

Summary: the understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis. complex and delicately balanced interaction between coagulation and inflammation involve all cellular and humoral components. elements of the coagulation system such as activated thrombin, fibrinogen or factor xa may increase inflammation by promoting the production of pro-inflammatory cytokines, chemokines, growth factors and adhesion molecules that lead to a procoagulant state amplifying the pathological process. recent evidence supports inflammation as a common pathogenic contributor to both arterial and venous thrombosis, giving rise to the concept of inflammation-induced thrombosis. patients with infection of covid-19 and severe pneumoniae seem to have higher risk of thromboembolism. very few data are available regarding the biological disorders of coagulation in these patients. th purpose of this project is to analyze hemostasis and coagulation of patients with infection of covid-19 and severe pneumonia.


Eligibility criteria:
inclusion criteria: * patients hospitalized in medical icu with pneumonia due to covid-19 infection exclusion criteria: * patients\< 18 years

Keywords: covid-19 pneumonia ards venous ultrasound hemostasis coagulation
icd shock detection by a wearable

Conditions: Cardiac Arrest; Heart Arrest; Cardiopulmonary Arrest

Summary: trial to assess the ability of a wearable to detect defibrillation from an implantable icd

non-invasive, pain-free clinical evaluation of a wearable/proximity sensor designed to detect a high voltage therapeutic shock received by a patient from their implantable cardioverter defibrillator (icd) during defibrillation threshold testing (dft), which is a routine part of the clinical procedure.

Eligibility criteria:
inclusion criteria: * capable of understanding procedure and making informed consent * listed for elective icd implant * having routine dft as part of elective icd implantation exclusion criteria: * not indicated for icd implant * incapable of making informed consent * pregnant * not on stabilised anti-coagulation

Keywords: icd defibrillator
validity and reliability of the gpcog -tr

Conditions: Dementia

Summary: the general practitioner assessment of cognition (gpcog) was specifically developed as a brief cognitive screening tool to be used by general practitioners (gps). it consists of a patient section testing cognition and an informant section asking historical questions. the aim of this study was to test the validity and reliability of the turkish version of gpcog-tr on turkish older adults.


Eligibility criteria:
inclusion criteria: * age: least 55 years old * provide informed consent * diagnosed with dementia ( patient group) exclusion criteria: * living in a nursing home * presence of psychiatric disorders requiring treatment * presence of other comorbidity interfering with cognitive performance such as severe chronic heart failure, chronic obstructive pulmonary disease, diabetes, anemia impairment of auditory or visual perception * low education * known cognitive impairment (for control group only) * lack of a reliable informant.

Keywords: general practitioners early diagnosis
evaluation of behavioural psycho & physiological responses in people with asd during a blood test in routine care practice

Conditions: Autism Spectrum Disorder

Summary: the project is a prospective study designed to characterize behaviour and its psycho-physiological correlates of participants with asd (children and adults) in comparison with subjects without asd matched in age during blood test in common practice.

the project is a prospective study designed to characterize behaviour and its psycho-physiological correlates of participants with asd (children and adults) in comparison with subjects without asd matched in age during blood test in common practice. the aim is to analyse in an automated and standardised way video recording during a blood test performed as part of routine follow-up care for people presenting asd (children and adults), qualitative data (type of emotion) and quantitative (intensity) 1. emotional facial reactions 2. behavioural reactions (video recording of participants' movements) 3. physiological reactions (wireless smart watch worn on the wrist) 4. psychological reactions (self and hetero questionaires) to characterize the signs of pain and anxiety associated with this situation)

Eligibility criteria:
inclusion criteria: all participants : * person over 6 years of age * person who consent to participate in the study * membership of the social security scheme * person who not received analgesic treatment that may interfere with pain perception * person with medical prescription for blood sample participants with asd : * person with asd diagnosis * if applicable, legal authority consent to participate in the study exclusion criteria: all participants : * person with unstabilized drug therapy * person with acute or chronic pain * person with pathology or receiving a treatment which can have an impact in modification of the pain * person with oculomotor and/or neuro-motor disorders * pregnant or breastfeeding woman * person with deprivation of liberty * person who no consent to participate in the study or no consent to realised video recording participants without asd : * protected adult * person with asd diagnosis

Keywords: autism spectrum disorders behaviour emotions physiological reactions psychological reactions
phase ii study evaluating a combination of pegylated liposomal doxorubicin and dexamethasone for the treatment of immunocompetent patients with cerebral lymphoma relapsed or refractory to first-line chemotherapy with high dose methotrexate (mtxhd) and / or high-dose cytarabine.

Conditions: Cerebral Lymphoma B Cell Refractory

Summary: the protocol is to assess the overall response rate (complete response and partial response) of treatment with non-pegylated liposomal doxorubicin at a dose of 50 mg / m² in combination with dexamethasone in immunocompetent adult patients with primary brain lymphoma large b-cell refractory or relapsed after first-line treatment mtxhd and high-dose cytarabine, excluding strict eye lymphomas. this is a phase ii, open, prospective, multicenter, non-comparative with direct individual benefit.


Eligibility criteria:
inclusion criteria: * patient with cerebral lymphoma b cell refractory or relapsed within 12 months after first-line chemotherapy with high-dose methotrexate (1.5 g / m²) and high dose cytarabine (2g / m²) and / or radiotherapy or autologous, or patient with an indication against these treatments. refractory disease is defined by the absence of objective response to treatment or relapse within 3 months of it. a relapse is defined as disease progression after obtaining a complete or partial response. * age greater than or equal to 18 years * performance index less than 4 * illness measured by ct or mri * hematologic adequate: neutrophils\> 1.5 x 106 / l, platelets\> 100x106 / l * adequate hepatic function: alt / ast and bilirubin less than the upper limit of the normal laboratory * adequate renal function: creatinine clearance greater than 60 ml / min * adequate cardiac function measured by ejection fraction of the left ventricle\> 50% by echocardiography * informed consent signed * negative pregnancy test for women of childbearing age * able to understand the arrangements for monitoring the study and to comply * corticosteroids are only accepted during the first cycle exclusion criteria: * patients with immunosuppression from any cause (hiv, history of transplantation, immunosuppressive treatments ...) * prior treatment myocet ® or other anthracycline * active infection * surgery large (more than 3 days hospitalization) within 28 days before enrollment in the study, except for a diagnostic neurosurgical * hypersensitivity to any component of the treatment * contraindications to the administration of myocet ® and / or dexamethasone participation in a clinical trial within 4 weeks prior to study entry

Keywords: cerebral lymphoma b cell refractory myocet efficacy safety