Kornimate/medical-research-clean huggingface dataset:
an efficacy and safety study of miconazole and hydrocortisone cream in the treatment of vulvar candidiasis

Conditions: Vulva; Candidiasis

Summary: the purpose of this study is to evaluate the efficacy and safety of miconazole plus hydrocortisone cream in the treatment of participants with vulvar candidiasis (yeast infection of the vulva).

this is an open label (all people know the identity of the intervention), single-arm, prospective (study following participants forward in time) study to evaluate the efficacy and safety of miconazole plus hydrocortisone cream in participants with vulvar candidiasis. participants will be evaluated and assessed on the degree of pruritus (itchiness) and screened for candidiasis on the baseline. participants will apply the cream once enrolled and will be assessed for 1-hour to get the time to relief. each participant will apply the study medication topically (applied to skin) to the lesion twice daily up to day 14 by rubbing gently until it has been completely penetrated into the vulvar area affected and the treatment should be continued without interruption. participants will be followed-up after 14 days and will be assessed clinically for signs and symptoms of vulvar candidiasis; if not cured, participants will continue the medication up to day 28. primary efficacy endpoint will be the time needed to achieve pruritus relief. participants' safety will be monitored throughout the study.

Eligibility criteria:
inclusion criteria: - positive potassium hydroxide (koh) mount / gram stain (a method used to diagnose bacterial infection) of vulvar (the tissues around the opening to the vagina) scrapings - vulvar candidiasis with at least mild pruritus exclusion criteria: - participants with vaginal candidiasis (yeast infection of the vagina) - history of allergy to miconazone (an antifungal agent, is used for skin infections such as vaginal yeast infections) and/or other components of the study drug - pruritus caused by etiologic (the cause) agents aside from fungi - tuberculous (bacterial infection that usually results in a serious lung disorder) skin infection - herpes simplex (viral infection), vaccinia (vaccine used to eradicate smallpox), all forms of varicella (infection caused by the varicella-zoster virus), and vulvar malignancy (cancer)

Keywords: vulvar candidiasis miconazole hydrocortisone daktacort feminine care cream
efficacy of viscosupplementation associated with intra-articular corticosteroid injection versus intra-articular injection of corticosteroids alone in osteoarthritis of hip

Conditions: Hip Osteoarthritis

Summary: the current management of osteoarthritis is based on non-pharmacological and pharmacological means which include intra-articular injections. the recommendations on the management of hip osteoarthritis stipulate that intra-articular injections of corticosteroid may be considered in patients with an exacerbation not responding to oral treatments. several recent studies show the effectiveness of intra-articular corticosteroids compared with anesthetics. the intra-articular injection of viscosupplementation alone has never been validated in this indication since controlled studies did not show efficacy over placebo. at present, viscosupplementation is considered an anti-osteoarthritic symptomatic slow-acting and its interest is not yet established in hip osteoarthritis.

show the superiority of intra-articular injection of viscosupplementation in combination with corticosteroid compared to intra-articular injection of corticosteroid alone in the treatment of hip osteoarthritis.

Eligibility criteria:
inclusion criteria: * patients with hip osteoarthrosis (stage ii et iii according kellgren et lawrence) * walking alone patients * patient consenting to participate to the study * patient enrolled in the national healthcare insurance program * patient older than 18 years exclusion criteria: * patients with hip osteoarthrosis (stage i et iv according kellgren et lawrence) * patients with rapidly destructive hip osteoarthritis * patients with inflammatory rheumatism * patients with microcrystalline arthritis * patients with hip osteonecrosis * patients who received corticosteroids during the previous three months * patients who received a intra articular injection of viscosupplementation during the previous six months * patient with haemostatic disorder * patient with consumption of painkillers tier 3
shared oral care - improving oral care in institutionalized elderly in aalborg municipality

Conditions: Oral Health; Quality of Life

Summary: background: nationally and internationally, more people over the age of 65 and especially an increase of people over the age of 80 enter nursing homes with natural dentition and complex prostheses and bridges than previous generations. furthermore, there is an increased incidence of dental diseases in the elderly. this is leading to increased and different oral care needs. there is a large discrepancy between the elderly who need help with oral hygiene and the elderly who actually receive help. in order to improve the oral hygiene competencies of healthcare professionals at nursing homes, it is necessary to increase their education and improve organizational strategies. hypothesis: the intervention shared oral care improves the elderlys bleeding and plaque index after 6 months. study type: an intervention study. a cluster randomization of 14 nursing homes in aalborg municipality is carried out. outcome measures: change in mucosal-plaque score (mps) index change in oral related quality of life outcome measure time frame: change in mucosal-plaque score index measured at 0, 3 and 6 months. change in oral related quality of life measured at 0 and 6 months.


Eligibility criteria:
inclusion criteria: * elderly living in nursing homes in aalborg municipality having one or more natural dentition exclusion criteria: * no natural dentition
nephrologist follow-up versus usual care after an acute kidney injury hospitalization

Conditions: Acute Kidney Injury; Chronic Kidney Disease

Summary: the primary objective is to evaluate the impact of an aki follow-up clinic on major adverse kidney events (make) in comparison to hospitalized patients surviving an episode of aki who are not exposed to the aki follow-up clinic intervention.

survivors of acute kidney injury (aki) are at increased risk of chronic kidney disease (ckd) and death, but have inconsistent follow-up care. our team has developed and tested a model to deliver structured follow-up kidney care (the aki follow-up clinic) that is feasible and sustainable, with standardized assessments based upon clinical practice guidelines that are transferable to any setting. this study will randomize patients with kidney disease improving global outcomes (kdigo) stage 2-3 aki to the aki follow-up clinic or usual care (control group). the usual care group will have a letter outlining their aki diagnosis mailed to their family physician; the usual care group may still be referred to a nephrologist by their healthcare provider if desired, but these participants will not have access to the aki follow-up clinic pathways. the primary outcome is development of a major adverse kidney event (make), a composite of death, chronic dialysis, and estimated glomerular filtration rate (egfr) decline. outcomes will be ascertained after one year of follow-up, which is when aki follow-up clinic patients are transitioned back to their family doctor or general nephrologist based upon pre-specified graduation criteria. participants will also be followed using local hospital electronic resources and the institute for clinical evaluative sciences (ices) administrative databases in order to assess the long-term impact of early nephrologist follow-up on aki outcomes.

Eligibility criteria:
inclusion criteria: * age ≥ 18 yrs * kidney disease improving global outcomes (kdigo) stage 2 aki and above (including need for dialysis) exclusion criteria: * kidney transplant recipients * outpatient baseline egfr under 30ml/min/1.73m2 (by ckd-epi equation); ignore if baseline serum creatinine is unavailable * patients discharged from hospital with a persistent requirement for renal replacement therapy * clinical diagnosis or suspicion of: glomerulonephritis, vasculitis with kidney involvement, hemolytic-uremic syndrome, polycystic kidney disease, myeloma cast nephropathy * pregnancy * residence at a nursing home facility (rehabilitation and retirement home patients should not be excluded) * palliation as primary goal of care (defined as life expectancy ≤ six months or followed by a palliative care physician) * patients with previously established and ongoing nephrology follow-up (defined as ≥ one outpatient appointment with a nephrologist in the previous 12 months)

Keywords: acute kidney injury chronic kidney disease quality improvement
recurrence of arrhythmias after pulmonary veins isolation detected by icm

Conditions: Atrial Fibrillation

Summary: post marketing study, interventional, prospective, non randomised describe how the md is using the information of the icm in addition of standard fu(clinical exam and holter 24h)post af ablation(1 year fu).


Eligibility criteria:
inclusion criteria: * af thermoablation indication * informed consent signed, * age between 18 \& 75 exclusion criteria: * participation to other clinical trial * non compliant patient * pregnant women * left atrial thrombus * endocarditis, infection
association between dental implants properties and malodor production

Conditions: Halitosis

Summary: malodor production is bacterial in origin. the bacterial activity of anaerobic bacteria results in the breakdown of proteins and the production of foul smelling compounds. the aim of the study is to test the hypothesis that bacterial growth on dental implants contributes to malodor production and to see whether this contribution is associated with various properties of the dental implant such as: maker, type, depth ext.


Eligibility criteria:
inclusion criteria:dental patients that need dental implants - exclusion criteria:smokers -

Keywords: oral malodor dental implants
lower limb sclerotherapy of reticular veins and telangiectasias

Conditions: Telangiectasis

Summary: a long-term follow-up cohort study of patients that were assigned in two previous studies to compare the clinical results of sclerotherapy of telangiectasias and reticular veins of lower limbs using 0.2% polidocanol diluted in 70% hypertonic glucose (pdhg) vs 75% hypertonic glucose (hg) alone. all women, previously treated as aforementioned, were invited to be reevaluated regarding late maintenance and pigmentation over two years of follow-up. no new treatments were applied to the cohort.


Eligibility criteria:
inclusion criteria: * all patients that concluded the participation of 60 days in both primary studies were invited to reevaluate the actual status of treatment (maintenance of treated vessels) and late complications (pigmentation and matting). exclusion criteria: * patients who did not agree to be reassessed; * patients who were not found after all available forms of contact had been tried; * patients who went through any kind of intervention on the area of interest in lower limbs between the end of the intervention and the reevaluation for long-term follow-up.

Keywords: sclerotherapy veins telangiectasias hyperpigmentation
clinical trial on the use of autologous bone marrow stem cells in amyotrophic lateral sclerosis (extension cmn/ela)

Conditions: Amyotrophic Lateral Sclerosis

Summary: the purpose of this clinical trial is to assess the feasibility and the security of the intraspinal and intrathecal infusion of autologous bone marrow stem cells for the treatment of amyotrophic lateral sclerosis patients.

patients with amyotrophic lateral sclerosis (als) typically endure a progressive paralysis due to the continued loss of motoneurons that leads them to death in less than 5 years. no treatment has changed its natural history. intraspinal injections of bone marrow mononuclear cells (mnc) have been able to ameliorate the course of als in murine models, acting as pumps of trophic factors that keep the motoneurons functional. moreover, the clinical trial (study nct00855400 on www.clinicaltrials.gov) conducted by our research group to determine the safety and efficacy of autologous stem cell transplantation in amyotrophic lateral sclerosis in humans, found that this procedure is feasible and safe. continuing with that study, we have designed a phase i/ii clinical trial to check the feasibility of the intraspinal and intrathecal infusion of autologous bone marrow stem cells.

Eligibility criteria:
inclusion criteria: * diagnose established following the world federation of neurology criteria * more than 6 and less than 36 months of evolution of the disease * medullar onset of the disease * more than 18 and less than 70 years old * forced vital capacity ≥ 50% * total time of oxygen saturation \<90% inferior to 5% of the sleeping time * signed informed consent exclusion criteria: * neurological or psychiatric concomitant disease * need of parenteral or enteral nutrition through percutaneous endoscopic gastrostomy or nasogastric tube * concomitant systemic disease * treatment with corticosteroids, immunoglobulins or immunosuppressors during the last 12 months * inclusion in other clinical trials * unability to understand the informed consent

Keywords: amyotrophic lateral sclerosis bone marrow stem cells autologous safety
spect/ct in endocrine and neuroendocrine tumors

Conditions: Endocrine and Neuroendocrine Tumors

Summary: the value of fusion of functional and anatomical data has been described using several fusion techniques for various nuclear medicine procedures and morphologic imaging modalities (spect-ct, spect-mri, coincidence-ct). we hypothesize that nm -ct data has advantages over the data obtained using separately performed nm study and conventional anatomic imaging as ct. we hypothesize that more accurate localization of the radio-isotope activity on nm images will improve diagnostic accuracy and will have an impact on patient management: improved accuracy of nm study will improve tumor localization, the evaluation of the extent of disease and the post therapy follow up. it will direct other diagnostic procedures to lesions otherwise undetected, or exclude the need for more invasive procedures. it can also guide invasive procedures and radiation-therapy planning, thus improving therapy results and avoiding unnecessary treatment-related side effects.

the value of fusion of functional and anatomical data has been described using several fusion techniques for various nuclear medicine procedures and morphologic imaging modalities (spect-ct, spect-mri, coincidence-ct). we hypothesize that nm -ct data has advantages over the data obtained using separately performed nm study and conventional anatomic imaging as ct. we hypothesize that more accurate localization of the radio-isotope activity on nm images will improve diagnostic accuracy and will have an impact on patient management: improved accuracy of nm study will improve tumor localization, the evaluation of the extent of disease and the post therapy follow up. it will direct other diagnostic procedures to lesions otherwise undetected, or exclude the need for more invasive procedures. it can also guide invasive procedures and radiation-therapy planning, thus improving therapy results and avoiding unnecessary treatment-related side effects.

Eligibility criteria:
inclusion criteria: * patient referred for nm scintigraphy to assess the presence of endocrine or neuroendocrine tumors. * patient signed informed consent exclusion criteria: * the study will not be performed in pregnant or lactating women. * patient will not be able or willing to tolerate the scan until its completion.
shear wave elastography in adhesive capsulitis

Conditions: Adhesive Capsulitis

Summary: this study aimed to evaluate the contribution of sonoelastography in the diagnosis of adhesive capsulitis in patients with a clinical prediagnosis of adhesive capsulitis (ac) and inferior glenohumeral capsuloligamentous complex (ighcc) involvement demonstrated by magnetic resonance imaging (mri).

the study will include a total of 30 patients who will be diagnosed with ac based on clinical evaluation by physicians from various clinical departments, including physical medicine and rehabilitation, and orthopedics. the diagnosis will be confirmed by two experienced radiologists specializing in musculoskeletal imaging. based on clinical evaluation and mri findings, a control group of 34 individuals without suspected ac will be included. mri imaging will be performed using a 3 tesla mri scanner. sonoelastography will be performed using a siemens acuson-s2000 ultrasound device with a 9l4 (4-9 mhz) linear probe and the virtual touch quantification (vtq/arfi) method. shear wave elastography will be applied to the ighcc to obtain the mean shear wave velocity (swv) values. the contribution of sonoelastography in the diagnosis of adhesive capsulitis in patients with a clinical prediagnosis of adhesive capsulitis (ac) and inferior glenohumeral capsuloligamentous complex (ighcc) involvement will be investigated.

Eligibility criteria:
inclusion criteria: * having a preliminary diagnosis of adhesive capsulitis in physical medicine and rehabilitation or orthopedics clinic and the diagnosis confirmed by mri * giving consent to participate exclusion criteria: * presence of tumor, arthritis, surgical history, or trauma history in the relevant shoulder joint * cervical radiculopathy, a central or peripheral neurological deficit in the upper extremity * incomplete sequences or inability to evaluate images due to artifacts in mri imaging * presence of pain and/or limited movement to the extent that it hinders positioning or manipulation for ultrasound examination * unwillingness to participate in the study voluntarily

Keywords: magnetic resonance imaging shear wave elastography
delivery room practice change following the initiation of the nichd support trial

Conditions: Preterm Birth

Summary: this study was designed to analyze whether initiation of the nichd neonatal research network support trial was followed by a change in frequency of endotracheal intubation the delivery room in non-participants and whether these changes were associated with changes in management and outcomes. the investigators hypothesized that the investigators would observe following the initiation of the support trial a 33% reduction in the rate of intubation in the delivery room among non-participants preterm infants at parkland memorial hospital.


Eligibility criteria:
inclusion criteria: * all babies born at parkland memorial hospital with gestational age at least 24 weeks and less than 35 weeks between 01/2003 and 06/2010 exclusion criteria: * infants receiving comfort care * those with major congenital anomalies * those enrolled in the support trial

Keywords: intubation, intratracheal continuous positive airway pressure historical cohort studies clinical trial
a study of muse device for midlife women

Conditions: Women's Health; Insomnia; Sleep Disturbance

Summary: the purpose of this study is to see if it is feasible for midlife women to wear a brain activity sensing headband (muse-s) for management of sleep disturbances such as insomnia and sleep disruption


Eligibility criteria:
inclusion criteria: * women in the menopause transition or in menopause, based on clinical assessment * psqi score \> 5, with overall sleep quality rating of "fairly bad" or "very bad". * motivation vas score equal to or greater than 5 with overall motivation rating of on a scale of 0-10 with 0 being not motivated at all and 10 being extremely motivated. * access to an ipad, iphone, or android device. * have ability to provide informed consent. exclusion criteria: * suspected or confirmed obstructive sleep apnea. * moderate to severe vasomotor symptoms warranting prescription medication use. the fda categories for hot flash severity are classified as mild (sensation of heat without sweating), moderate (sensation of heat with sweating, able to continue activity), or severe (sensation of heat with sweating cause cessation of activity). * use of hormone therapy or hypnotic agents. * use of supplements known to affect sleep. * a known, active, untreated clinically significant psychiatric condition. * use of an investigational drug within 30 days of study enrollment or presence of a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder adherence. * currently (within the past 3 weeks) been practicing mindfulness training on a weekly/regular basis.
safety of thoracoscopy in patients with high risk

Conditions: Pleural Diseases

Summary: medical thoracoscopy can be performed for diagnostic as well as therapeutic purposes. thoracoscopy in the diagnosis of pleural diseases is highly sensitive for detecting pleural neoplasia with negative pleural fluid cytology and in the diagnosis of tuberculosis. the indication of thoracoscopy in patients with pleural effusion has been optimized. in some studies medical thoracoscopy has been claimed a useful diagnostic tool with a very low rate of complications. however the investigators do not know its safety on high risk patients. because many patients having suspected malignancy have bed conditions due to other health problems such as coronary heart diseases, copd, arrythmia, hypoxemia. in this study the investigators aimed to test the safety of medical thoracoscopy in the patients with high risk for complications.


Eligibility criteria:
inclusion criteria: * patients with exudative pleural effusion exclusion criteria: * patients without pleural effusion

Keywords: thoracoscopy pleural diseases complications safety
preconceptional thromboprophylaxis in recurrent pregnancy losses caused by antiphospholipid syndrome

Conditions: Recurrent Pregnancy Losses; Positive Anti Phospholipid Syndrome

Summary: preconceptional use of low molecular weight heparin (enoxaparin) and aspirin in patient with recurrent miscarriages with positive anti phospholipid antibodies increase the implantation rate and the duration of pregnancy with low complications to the mother and the baby.

preconceptional heparin during follicular or luteal phase,improves the implantation rate by increasing the blood flow and increasing the implantation factors,also decreasing the pregnancy complication resulting from antiphospholipid syndrome (aps).

Eligibility criteria:
inclusion criteria: 1. all women with recurrent first-trimester miscarriage and all women with one or more second-trimester miscarriage who screened before pregnancy for antiphospholipid antibodies. 2. to diagnose antiphospholipid syndrome it is mandatory that the woman has two positive tests at least 12 weeks apart for either lupus anticoagulant or anticardiolipin antibodies of immunoglobulin g and/or immunoglobulin m class present in a medium or high titre over 40 g/l or ml/l,or above the 99th percentile). in the detection of lupus anticoagulant, the dilute russell's viper venom time test together with a platelet neutralisation procedure is more sensitive and specific than either the activated partial thromboplastin time test or the kaolin clotting time test. anticardiolipin antibodies are detected using a standardised enzyme linked immunosorbent assay. exclusion criteria: 1. age above forty years old . 2. intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy). 3. fibroids distorting uterine cavity . 4. abnormal parental karyotype . 5. other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (sle).

Keywords: recurrent miscarriages recurrent pregnancy loss aps anti coagulants in pregnancy