Kornimate/medical-research-clean huggingface dataset:
longitudinal study on the evolution trend and influencing factors of postoperative reflux of esophageal cancer based on peptest technique

Conditions: GASTROINTESTINAL NEOPLASMS

Summary: the goal of this observational study intends to explore the evolution trend and related factors of postoperative reflux of esophageal cancer based on peptest detection, in order to identify postoperative reflux the main question it aims to answer are: to provide evidence for high-risk groups, improvement of surgical methods for esophageal cancer, and development of health education programs to prevent postoperative reflux. using convenient sampling method, patients undergoing esophagectomy in thoracic surgery department of cancer hospital of chinese academy of medical sciences from january 1, 2023 were continuously enrolled. peptest was performed once before surgery, before discharge, 1 month, 3 months, and 6 months after surgery. the incidence of pathological reflux at 5 time points before and after surgery was observed and compared (that is, both t-line and c-line were shown). the trend of pepsin content in saliva before and after operation; the relationship between pathological reflux and surgical factors; the relationship between pathological reflux and life habits after operation; relationship between pathological regurgitation and demographic characteristics.

the subjects of this study were selected from the patients who underwent esophagectomy in the department of thoracic surgery of cancer hospital of chinese academy of medical sciences from january 1, 2023 to december 1, 2023, and the patients who underwent esophagectomy in the department of thoracic surgery of cancer hospital of chinese academy of medical sciences from january 1, 2023. peptest was performed once before surgery, before discharge, 1 month, 3 months, and 6 months after surgery. to describe the evolution trend of postoperative reflux in patients with esophageal cancer can be used for anticipatory sexual health education. to explore the relevant factors of reflux: to identify the inherent factors, such as gender, bmi, etc., to give preventive intervention to high-risk groups; the variable factors such as the length and width of the tube stomach can be improved.

Eligibility criteria:
inclusion criteria: 1. patients who were pathologically diagnosed with esophageal cancer and underwent esophagectomy for esophageal cancer. 2. the patient can communicate in mandarin. 3. those who can come to the hospital for review on time. exclusion criteria: 1. people with cognitive impairment or mental illness. 2. complicating other serious life-threatening diseases (such as leukemia or autoimmune diseases). 3. unwilling to participate in the study.
pivotal response treatment package for young children with autism

Conditions: Autism Spectrum Disorder (ASD); Autism

Summary: this is a research study examining the effectiveness of a pivotal response treatment package (prt-p) in targeting language skills in young children with autism.

researchers at the stanford university school of medicine are seeking participants for a research study examining the effectiveness of a pivotal response treatment package (prt-p) in targeting language skills in young children with autism. research has demonstrated that behavioral interventions, such as pivotal response training (prt), lead to improvements in the core symptoms of autism. researchers have begun to develop strategies to investigate the effectiveness of combining a parent training program teaching parents how to implement prt with in-home, therapist-implemented treatment. to determine the effectiveness of a prt-p, it will be compared to a delayed treatment group (dtg) by conducting a randomized controlled 24-week trial. this research will allow us to help in the development of therapeutic approaches that can meet the increasing service demands for families. we hope that investigating interventions that aim to improve core deficits will aid clinicians in providing better care for children with autism.

Eligibility criteria:
inclusion criteria: * diagnosis of autism spectrum disorder (asd) based on autism diagnostic interview- revised (adi-r), autism diagnostic observation schedule (ados-2), and expert clinical opinion * males and females in good medical health between 2.0 and 5.11 years * ability to participate in the testing procedures to the extent that valid standard scores can be obtained * language delay as measured by the preschool language scale: standard score at least 1 standard deviation below average for expressive language ability * stable treatment, speech therapy, school placement, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation * no more than 60 minutes of individual 1:1 speech therapy per week * availability of at least one parent who can consistently participate in parent training and research measures * parents intend on continuing pivotal response treatment package (prt-p) for a minimum of 12 weeks * parents must be 18 years of age or older exclusion criteria: * current or lifetime diagnosis of severe psychiatric disorder, such as bipolar disorder * receiving in-home applied behavior analysis (aba) of 10 hours or more * a genetic abnormality, such as fragile x * presence of active medical problem, such as unstable seizure disorder or heart disease * previous adequate prt trial * participants living more than 50 miles from stanford university * at least one room of the house must be available to be dedicated to treatment during session times * there must be no serious health and safety risks present in the home environment * the research team has the right to refuse to perform sessions in-home even if the criteria above are met

Keywords: autism spectrum disorder (asd) autism
computer-based treatment for social anxiety disorder

Conditions: Social Anxiety Disorder

Summary: the present study is an open trial that seeks to examine the feasibility, acceptability, mechanism, and efficacy of a recently developed computer-based therapy in individuals with social anxiety disorder (sad)

this randomized clinical trial examines the feasibility, acceptability, mechanism, and relative efficacy of two "doses" (standard 4-week/8 session vs. extended 8-week/12-session) of a recently developed computer-based therapy in individuals with social anxiety disorder (sad). the purpose of this study is to assess whether a brief computer-based research treatment, provided in 30 minutes sessions, helps improve social anxiety symptoms, and by what mechanism. the study will also assess the effect of research treatments on brain activity using magnetic resonance imaging (mri).

Eligibility criteria:
inclusion criteria: * males and females between the ages of 18 and 60 * current primary diagnosis of sad * score of at least 50 on the liebowitz social anxiety scale (self-rated version) * fluent in english and willing and able to give informed written consent and participate responsibly in the protocol * normal or corrected-to-normal vision exclusion criteria: * present or past psychotic episode, psychotic disorder, schizophrenia, schizoaffective disorder, or bipolar disorder * current severe depression * suicidal ideation or behavior * current diagnosis of posttraumatic stress disorder, obsessive-compulsive disorder, bipolar disorder, manic episode or tic disorder * current or past organic mental disorder, seizure disorder, epilepsy or brain injury * current unstable or untreated medical illness * severe alcohol use disorder, severe cannabis use disorder, and any severity of other substance use disorder (except nicotine use disorders allowed) * use of psychiatric medication in the past month other than a stable dose of selective serotonin reuptake inhibitors (ssris) for a least 3 months * any concurrent cognitive behavioral therapy; other psychotherapy that was initiated in the past 3 months * pregnancy, or plans to become pregnant during the period of the study - will be assessed by urine * contraindication to mri scanning: * paramagnetic metallic implants or devices contraindicating magnetic resonance imaging or any other non-removable paramagnetic metal in the body (e.g. pacemaker, paramagnetic metallic prosthesis, surgical clips, shrapnel, necessity for constant medicinal patch, some tattoos) * being unable to tolerate the scanning procedures (i.e., severe obesity, claustrophobia)

Keywords: sad social anxiety social phobia
computed tomography screening for early lung cancer, copd and cardiovascular disease in shanghai, china

Conditions: Lung Neoplasms; Mass Screening; Chronic Obstructive Pulmonary Disease; Cardiovascular Disease

Summary: low-dose chest computed tomography (ct) is considered as a screening method for early detection of lung cancer in the population at risk, and it also allows to detect chronic obstructive pulmonary disease (copd) and cardiovascular disease (cvd). studies in european population showed the benefit of volumetric assessment of ct screening-detected lung nodules compared to diameter-based assessment. screening for copd and cvd, in addition to lung cancer, may significantly increase the benefits of low-dose ct lung cancer screening. the objective is to assess the screening performance of volume-based management of ct-detected lung nodule in comparison to diameter-based management, and to improve the effectiveness of ct screening for copd and cvd, in addition to lung cancer, based on quantitative measurement of ct imaging biomarkers in a chinese screening setting. thus, a population-based comparative study will be performed in shanghai, china.

the study will recruit 10,000 asymptomatic participants between 40 and 74 years old from shanghai urban population. the 5000 participants in the intervention group will undergo a low-dose ct scan at baseline and one year later, and will be managed according to european volume-based protocol. the 5000 participants in the control group will undergo a low-dose ct scan according to the routine ct protocol and will be managed according to the clinical practice. epidemiological data will be collected through questionnaires. in the fourth year from baseline, the diagnosis of the three diseases will be collected. the screening performance will be compared between volume-based and standard protocol for managing early-detected lung nodules. the effectiveness of quantitative measurement of ct imaging biomarkers for early detection of lung cancer, copd and cvd will be evaluated. the detected lung nodules in the intervention group will be classified into three groups depending on nodule volume: \ 300 mm3 (positive result). in case of a negative result, a ct scan after one year is recommended. in case of an indeterminate result, a 3-month follow up ct is recommended at which vdt will be assessed. for short vdt (\ 400 days) is considered a negative screening result. in case of a positive result, referral to a multidisciplinary team is recommended for further investigation. the detected nodules in the control group will be managed according to the recommended cut-off values of diameter from nccn clinical practice guideline in oncology for lung cancer screening.

Eligibility criteria:
inclusion criteria: 1. asymptomatic (without complaints of chest discomfort) residents registered in shanghai city. 2. age between 40-74 years old 3. no history of lung cancer (self-reported). exclusion criteria: * pregnant women will be excluded.
hyperoxia and hypertonic saline in septic shock

Conditions: Septic Shock; Adult Respiratory Distress Syndrome

Summary: assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure occurences. to date, only scarce data are available. side effects are not well described. therefore we designed a randomized clinical trial in order to assess the early administration of hypertonic saline and oxygen in the very early beginning of septic shock.

the study is designed as factorial 2x2. patients will be stratified at the randomisation according the presence or absence of acute respiratory distress syndrome in order to perform a sub group analysis for all outcome criteria.

Eligibility criteria:
inclusion criteria: * patients with less than 6 hours septic shock according criteria of bone * minimal dose of catecholamines at least 0.1 µg/kg/min * patient with mechanical ventilation * written informed consent exclusion criteria: * age \< 18 years * pregnancy * participation in other trial with the same endpoint * moribund * absence of registration in french health care system * patient protected by law * hypernatremia \ 145 mmol/l * patient with p/f \ 5 cms of water * intracranial hypertension * patient admitted for cardiac arrest * overt cardiac failure

Keywords: sepsis shock hyperoxia hypertonic saline
early administration of l-carnitine in hemodialysis patients

Conditions: Complication of Hemodialysis; Hyperthyroidism Treated or Under Control

Summary: hemodialysis is a cause of carnitine deficiency. the deficiency of carnitine induces an anemia by an increase fragility of the red blood cells, a muscular fatigue and a cardiac dysfunction. we proposed to evaluate the benefit of an early administration of l-carnitine in hemodialysis patients. the patients should be included in the first month after the start of chronic hemodialysis, randomized to receive l-carnitine or placebo and should be followed-up during one year.

the first aim of the study is to compare the resistance index to erythropoietin (hemoglobin level / rhuerythropoietin dose) with l-carnitine versus placebo double blind randomized study evaluating the supplementation with l-carnitine versus placebo in patients beginning chronic hemodialysis for less than 1 month. primary outcome to compare rhuerythropoietin resistance index defined as hemoglobin level / rhuepo dose ratio with l-carnitine and with placebo. secondary endpoints to compare acylcarnitine / carnitine ratio, number of red blood cells transfusion, physical status, quality of life, hypotensive episodes, lipid profile, diabetes profile, albuminemia, c reactive protein. several variables that influenced primary and secondary endpoints will be included in a multivariate analysis; albuminemia, c reactive protein, iron status, dialysis efficiency, protein intake, lipid intake, treatment with additional vitamins (c, b9, b6), treatment with statins, treatment of predialysis hypotension by midodrine, antihypertensive treatments. statistical analysis: * description of the cohort * comparisons of each evaluated variables between the 2 treatments * anova study for repeated measurements from inclusion to month-12 for hb / rhuepo dose to compare the course of the ratio between each group in intention to treat analysis * analysis of the ratio hb / rhuepo month by month and taking into account tempera withdrawal following analysis in both intention to treat and per protocol analysis: * acylcarnitine / carnitine ratio by anova for repeated data * number of predialysis hypotension by chi2 test * number of red blood cells transfusion by chi2 test * sf-36 physical status by comparison of mean * sf-36 total score by comparison of mean * lipid profile by anova for repeated data * hba1c by anova for repeated data * variables that influenced primary and secondary variables will be analyzed by multivariate analysis * statistical study of clinical events per month

Eligibility criteria:
inclusion criteria: * patient with less than 1 month on hemodialysis. * treated with rhuepo. * male or female aged of more than 18 years old. * with contraception treatment for women of procreation age. * having received and understand information. exclusion criteria: * patients with no need of rhuepo * patients with cancer disease * patients with life expectancy under 6 months * patients having a proved carnitine deficiency before the start of hemodialysis

Keywords: l-carnitine supplementation hemodialysis anaemia erythropoietin responsiveness
single session pain education

Conditions: Chronic Pain

Summary: to pilot single session pain education classes aimed at improving outcomes and behaviors in patients with chronic pain.


Eligibility criteria:
inclusion criteria: * chronic pain patients, pain longer than 3 months * ability to adhere to and complete study protocols exclusion criteria: * not fluent in english * recent injury at the discretion of the researcher * previous completion of pain education class at the discretion of the researcher * current cancer diagnosis or other medical condition at the discretion of the researcher
titan® one touch release inflatable penile prosthesis

Conditions: Erectile Dysfunction

Summary: the purpose of this study is to assess the ease of deflation of the titan® otr pump.


Eligibility criteria:
inclusion criteria: * participant has an estimated life expectancy of more than 5 years * participant has been diagnosed with erectile dysfunction (impotence) * participant is willing to have the titan otr ipp implanted * participant is able and willing to complete all follow-up visits and procedures indicated in the protocol exclusion criteria: * participant is unable or unwilling to sign the informed consent form and /or comply with all follow-up requirements according to the study protocol * participant had a previous penile prosthesis or prior penile enlargement surgeries * participant has a compromised immune system, such as systemic lupus erythematosus, discoid lupus, or scleroderma * participant has had a myocardial infarction or coronary artery stent placement within 2 months prior to treatment * participant currently has uncontrolled or severe diabetes or other disease significantly reducing wound healing ability * participant does not have the manual dexterity or mental ability to operate the pump * participant has chordee or priapism * participant has penile sensory neuropathy * participant has serious bleeding disorder

Keywords: erectile dysfunction penile implant titan
intensive statin therapy in pci patient with acute coronary syndrome

Conditions: Myocardial Infarction; Unstable Angina

Summary: compare with regular regimen, the aim of this study is to testify whether having more statin during pci will benefit in chinese population, and to find out optimal dose of the drug for patient after pci.

this study is designed to find out whether patients undergoing pci can benefit from intensive atorvastatin treatment compared with routine treatment on chinese population.

Eligibility criteria:
inclusion criteria: * 18-85 years old * patients with clinical diagnosis of acs * evidence of a personally signed and dated informed consent document exclusion criteria: * taking or, needing to take atorvastatin over than 20mg/d or any other equivalent statin in the next 6 months, or needing to take fibrates simultaneously according to investigators' judgment. * ldl-c \< 1.8mmol/l in patients without statin therapy in 1 months * endstage congestive heart failure, or lvef \< 30% * active hepatic disease or hepatic dysfunction, or ast/alt \> 1.5unl * myopathy or increased creatine kinase (ck\>2 unl) * severe renal dysfunction(scr \> 3 mg/dl or 264μmol/l) * allergic or experienced serious adverse reaction to hmg-coa reductase, or ineligible to take statin as investigator's judgment * severe aortic valve stenosis or severe mitral stenosis, obstructive hypertrophic cardiomyopathy, pericardial diseases * pregnancy, lactation, or child bearing potential women without any effective contraception * accompanied with malignant disease or other disease, which cause life expectancy \< 6 months * participating in other interventional clinical trails using drugs or devices * patients with any condition which, in the investigator's judgment, might increase the risk to the subject for any adverse event or abnormal laboratory finding

Keywords: myocardial infarction unstable angina
premedication simethione improves visibility during bowel cleansing for colonoscopy

Conditions: Bowel Preparation Scale; the Amount of Air Bubble; Adenoma Detection Rate

Summary: to evaluate the efficacy, visibility of low volume polyethyleneglycol-simeticone (2-lpeg-s) for colonoscopy.

in this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. group a patients (n = 300) used only 2 l peg before colonoscopy. patients in group b (n = 300) were additionally advised to simeticone plus 2 l peg, the overall quality of colonoscopy cleaning was evaluated using the boston bowel preparation scale by a single endoscopist who was blinded to the intervention. visibility was blindly assessed for the amount of air bubbles and adenoma detection rate (adr). difficulty of procedure, and adverse events were also evaluated.

Eligibility criteria:
inclusion criteria: * patients are between 18-65 years old * undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up exclusion criteria: * suspected gastrointestinal obstruction or perforation * severe acute inflammatory bowel disease * toxic megacolon * ileus or gastric retention, ileostomy, * hypersensitivity to any of the ingredients * pregnancy and lactation and/or at a risk of becoming pregnant
dysphagia in oculopharyngeal muscular dystrophy (opmd)- evaluation, endoscopic examination of swallowing, treatment and long term follow up

Conditions: Dysphagia

Summary: the investigators aimed to review the natural history of dysphagia and dysphonia in opmd in order to identify the best candidates and the proper timing to perform dysphagia alleviating procedures in both heterozygote and homozygote patients from the large pool of cases with this disease in israel.

clinical evaluation of patients suspected of having opmd. genetic confirmatory tests (diagnostic dna test) at the genetic unit in afula hospital. clinical follow-up with endoscopic fiber optic evaluation of swallowing. pre-operative assessment. crycopharyngeal myotomy intervention in selected patients. nutrition follow-up.

Eligibility criteria:
inclusion criteria: * heterozygote and homozygote opmd patients exclusion criteria: -

Keywords: opmd, dysphagia dysphagia severity nutritional state speech quality upper esophageal sphincter myotomy