Kornimate/medical-research-clean huggingface dataset:
dynamic monitor of portacaval pressure gradient

Conditions: Liver Cirrhosis

Summary: portacaval pressure gradient (ppg) plays an important role in prediction the outcomes of cirrhotic patients undergoing tips. an ppg over 20 mmhg indicates a high risk of failure to control bleeding or preventing rebleeding, while patients with ppg \<12 mmhg are free from the risk of variceal bleeding. transjugular intrahepatic portosystemic shunt (tips) markedly reduces ppg and is a very effective treatment for portal hypertension. a recent study showed that timing affects measurement of portacaval pressure gradient (ppg) after tips placement in patients with portal hypertension. the immediate ppg after tips placement cannot predict the long-term prognosis, while ppg measured with the patient on stable clinical conditions correlates with long term ppg and clinical outcomes. however, this finding remain to be validated. previous studies have demonstrated that the achievement of a hepatic vein pressure gradient \<12 mmhg eliminated the risk of recurrent variceal hemorrhage. therefore, a post- tips ppg \<12 mmhg was initially proposed as a hemodynamic target of tips, independent of the indication. it is important to note that most studies on hemodynamic targets were done before the introduction of covered stents and have not been adequately updated since then.therefore, whether a post-tips ppg target \<12 mmhg is the best cutoff for patients receiving a covered stent for the treatment of portal hypertension complications needs confirmation in well-designed studies.this study aims to dynamically monitor the change of ppg after tips procedure in patients with portal hypertension, and investigate its prognostic value in predicting patient outcome.


Eligibility criteria:
inclusion criteria: * patients with portal hypertensive complications * receiving tips due to variceal bleeding or refractory ascites * successful covered tips procedure * written informed consent exclusion criteria: * lactating or pregnant * malignancies * uncontrolled infection (\> grade 2) * severe cardiac, pulmonary or renal dysfunction * previously treated with tips * previous liver transplantation * history of spontaneous overt he or recurrent he

Keywords: liver cirrhosis transjugular intrahepatic portosystemic shunt pressure gradient outcome prediction
prone breath hold technique to decrease cardiac and pulmonary doses in women receiving left breast radiotherapy

Conditions: Breast Cancer

Summary: this is a pilot study to determine whether the addition of inspiratory hold (breath holding) can decrease the radiation dose that the heart and lung receive for patients being treated for left sided breast cancer.

subjects have a standard of care ct simulation, which includes an additional breath hold ct. inspiratory gated breath-hold will be used. two radiation plans will be generated: one for the ct scan performed free breathing, and one for the ct scan performed with inspiratory gated breath hold. the cardiac and lung doses will be determined. at the discretion of the treating physician, the plan with the lower cardiac and lung dose may be used to treat the patient.

Eligibility criteria:
inclusion criteria: * patients of dr. gonzalez * ≥18 years of age * node-negative left breast cancer * invasive or dcis breast cancer * prior lumpectomy * deemed appropriate for treatment in the prone position by the treating physician * able to tolerate prone position and breath hold during ct simulation exclusion criteria: * \<18 years of age * patients requiring treatment in supine position
cultural adaptation of group cbt psychosis manual and establishing its efficacy in pakistan

Conditions: Psychotic Disorders; Psychosis; Schizophrenia and Related Disorders

Summary: a study aimed to culturally adapt group cognitive behavioral therapy for psychosis (cbtp) for pakistani patients with schizophrenia. fifty inpatients from pimh were randomly assigned to experimental (n=25) and control (n=25) groups. both groups showed significant improvement in symptoms post-intervention (p\&lt;0.05). this suggests that culturally adapted group cbtp is effective for schizophrenia patients in hospital settings, addressing the scarcity of cbt-trained therapists in government hospitals in pakistan.

a clinical trial was conducted aiming to culturally adapt and pilot test a group cognitive behavioral therapy for psychosis (cbtp) protocol for pakistani patients diagnosed with schizophrenia spectrum disorder. this research was particularly significant given the prevalence of psychosis in pakistan and the scarcity of trained therapists, especially in government hospitals. methodology: participant selection: purposive sampling was utilized to select participants from the psychiatric institute of mental health (pimh) who were diagnosed with schizophrenia spectrum disorder and were inpatients receiving medication. sample size: a total sample of n=50 was obtained, with participants randomly assigned to either the experimental (n=25) or control group (n=25). assessment measures: various assessment measures were employed to evaluate the efficacy of the intervention, including the positive and negative syndrome scale of schizophrenia (panss), rosenberg's self esteem scale, insight scale, brief cope, perceived stress scale, and the psychotic symptom rating scales (psyrats). intervention: the experimental group received manualized group cbt intervention consisting of 24 sessions over a duration of 3 months. the intervention was culturally adapted to suit the needs and context of pakistani patients. importantly, there were no dropouts from either group during the intervention period. statistical analysis: an analysis of covariance (ancova) was conducted to compare pre- and post-intervention ratings between the experimental and control groups.

Eligibility criteria:
inclusion criteria: a clinical diagnosis of schizophrenia or psychotic disorder for at least 5 years. aged between 18 and 65. the exclusion criteria : a severe learning disability, an organic brain disorder , a high level of disturbed behavior, or a significant risk of suicide or homicide.

Keywords: group cbt cbt schizophrenia
assessment of small intestinal bowel epithelial gaps in irritable bowel syndrome

Conditions: Irritable Bowel Syndrome; Inflammatory Bowel Disease

Summary: the study aims to: 1. determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (ibs) is different from that in inflammatory bowel disease (ibd) patients and normal controls by confocal laser endomicroscopy (cle). 2. evaluate the relationship between the density of epithelial gaps and ibs subtypes, and visceral hypersensitivity.

epithelial cells lining the gastrointestinal tract serve as a barrier between the gut lumen and the body. previous study has shown that epithelium is punctuated by discontinuities named "gaps". confocal laser endomicroscopy could be used as a useful tool for detecting epithelial gaps in vivo, and epithelial gap density in terminal ileum of ibd patients was elevated compared with normal control using cle. so this study aims to determine whether the density of epithelial gaps in terminal ileum of patients with ibs is different from that in ibd patients and normal controls by cle, and to evaluate the relationship between the density of epithelial gaps and ibs subtypes, and visceral hypersensitivity.

Eligibility criteria:
inclusion criteria: * bowel habits alterations meeting ibs rome iii criteria and indications for colonoscopy investigation * patients with history of inflammatory bowel disease * asymptomatic individuals for health surveillance or patients for follow up after polypectomy * patients complained of hemafecia but colonoscopy revealed only haemorrhoid exclusion criteria: * patients with known cancers or abdominal surgery * alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass * patients who are unwilling to sign or give the informed consent form * patients who are allergic to fluorescein sodium * patients with impaired cardiac, liver or renal function * patients with coagulopathy * patients with pregnancy or breastfeeding

Keywords: irritable bowel syndrome inflammatory bowel disease confocal laser endomicroscopy
ultrasound features of trigger finger

Conditions: Trigger Finger

Summary: our aim in this study; to compare the ultrasound findings seen in trigger finger patients with healthy volunteers. thus, ultrasound findings associated with trigger finger development will be documented

a1 pulley thickness, flexor tendon thickness, and presence of nodules at the mcp joint level of the trigger finger patients will be recorded. the same measurements will be made in age- and sex-matched healthy volunteers, followed by comparison and analysis.

Eligibility criteria:
inclusion criteria: * aged over 18 years * to have trigger finger (for patient group) * not to have trigger finger (for healthy group) exclusion criteria: * aged under 18 * wound or infection in the imaging area
clinical study of qingremoshen granule to treat idiopathic membranous nephropathy

Conditions: Idiopathic Membranous Nephropathy

Summary: the purpose of this study is to evaluate the clinical safety and efficacy of qingremoshen granule to treat idiopathic membranous nephropathy.


Eligibility criteria:
inclusion criteria: * women and men who had a clinic and biopsy-proven idiopathic membranous nephropathy; * 6.0g≥24 hour urinary protein≥1.0g; * serum albumin concentration≥26g/l; * chronic kidney disease (ckd)≤3 stage (egfr\>30ml/min/1.73m2 mdrd); * willing to participate in the trial and signed an informed consent. exclusion criteria: * secondary membranous nephropathy; * patients with one of the following circumstances- malignant tumors or malignancy, hiv infection, a history of mental illness, any serious systemic infection, serious gastrointestinal diseases, circulating hepatitis b surface antigens positive or persistent abnormal serum transaminase, abnormal glucose metabolism or diabetes mellitus; * pregnant and lactating women; * undergoing other clinical trials.

Keywords: idiopathic membranous nephropathy traditional chinese medicine randomized control trial
short term effects and risks of physical exercise in subjects with hypohidrotic ectodermal dysplasia

Conditions: X-Linked Hypohidrotic Ectodermal Dysplasia; Exercise-induced Rise of Body Temperature

Summary: because of their lack of sweat glands individuals with hypohidrotic ectodermal dysplasia (hed) are at particular risk of life-threatening hyperthermia during exercise in a warm environment. in this study, the effects of physical exercise are investigated in boys and male adolescents with x-chromosomally inherited hed as well as age-matched controls, who undergo standardized exertion on a bicycle ergometer at ambient temperatures of 25°c and 30°c. body core temperature during and after ergometry, heart rate, performance, and serum lactate as a marker of metabolic stress are measured. subjects with hed are expected to show an endangering rise of body temperature in connection with physical exercise. to clarify, whether novel cooling devices may reduce the likelihood of overheating, the effects of such devices are evaluated at 30°c.


Eligibility criteria:
inclusion criteria: * for patients: hypohidrotic ectodermal dysplasia caused by eda gene mutations * regular fluid intake prior to the investigation * written informed consent exclusion criteria: * acute febrile illness * acute or chronic heart disease * arterial hypertension * gastrointestinal disorders * implantable electronic devices * mri investigation scheduled for the 5 days subsequent to the study * clinical signs or diagnostic findings of dehydration

Keywords: hypohidrotic ectodermal dysplasia exertional hyperthermia cooling device
the long term outcomes of rehabilitation and drug treatment for in urgency urinary incontinence

Conditions: Urge Urinary Incontinence

Summary: * urinary urge incontinence (uui) is the involuntary urine loss associated with a strong sensation to void. * uui usually associated with reduced bladder capacity. * the pathophysiology is unclear. * pelvic floor muscle dysfunction and detrusor instability have been suggested as possible mechanisms. * standard treatment includes anticholinergic medication and behavior modification. * the study aims to compare the long term effectiveness of 4 different approaches to the treatment of women with urge urinary incontinence (uui): 1. pelvic floor rehabilitation (includes muscle training+behavioral intervention+bladder training) 2. pelvic floor muscle training alone 3. bladder training alone 4. drug treatment with tolterodine. * study variables will include: impairment ratings, quality of life, and cost-effectiveness. * this study addresses three issues: 1. the long term efficacy and cost-effectiveness of the various treatment options. 2. to identify the factors involved in determining the effectiveness of drug or behavioral therapy. 3. the pathophysiology of uui. by subdividing the rehabilitation group into 3 arms, we hope to shed light on the mechanism of dysfunction. a better response in one group will help localize the problem to pelvic floor muscles or to detrusor instability.

the study has 3 phases: before treatment (phase i), immediately after 3 months of treatment (phase ii), and 1 year post-entry (phase iii) women with uui will be divided randomly into one of the four treatment groups. every subject will participate in 4 visits. the drug group treatment consists of administration of tolterodine sr 4 mg daily for 3 months. subjects who assigned to the pelvic floor rehabilitation, pelvic floor muscle training, and bladder training groups will be treated via 4 visits to a physical therapist, who is trained in the procedures. the chief researcher (rk) will be blinded to the treatment groups and will perform the outcome measures in all phases. study variables will include impairment ratings, quality of life, and cost-effectiveness

Eligibility criteria:
inclusion criteria: * complaints of urinary leakage \> 3 in last month (not stress incontinence) * functionally independent subjects exclusion criteria: * urinary tract infection * urogenital prolapse * unstable diabetes * neurological or psychiatric disease * narrow angle glaucoma * after colposuspension or sling surgery * mini mental state examination \<24

Keywords: urge urinary incontinence rehabilitation anticholinergic
modification of cognitive processing therapy (cpt-c) for ptsd and alcohol dependence

Conditions: Alcohol Dependence; PTSD

Summary: objective: to develop a detailed treatment manual that modifies the existing cpt-c treatment protocol to allow for concurrent treatment of ptsd and ad, and to obtain some pilot data regarding its efficacy. hypothesis: we predict that cpt-c will significantly reduce the number of drinking days (measured by the timeline follow back method \[tlfb\]) and reduce the symptoms of ptsd (measured by the \[caps and pcl\] scores). design: this is a non-randomized, prospective study in which all participants will receive the modified cpt-c for 12 weeks by trained cpt-c clinicians, with each session lasting approximately 1-1.5 hours). modifications to cpt-c include psychoeducation about alcohol use as an avoidance of ptsd symptoms integrated throughout treatment, integration of coping skills training for ad, weekly breathalyzer tests to measure blood alcohol level, and use and collection of daily dairies of alcohol use.


Eligibility criteria:
inclusion criteria: 1. males and females between the ages of 21-65 years old. 2. current alcohol dependence as determined by the structured clinical interview for dsm-iv axis i disorder (scid; first et al. 1996). abstinence no more than past 29 days. primary substance dependence diagnosis of alcohol dependence. 3. current ptsd as determined by the clinician administered ptsd scale for dsm-iv(caps; blake et al. 1995). 4. participants on psychiatric medication must be on a stable regimen for at least 2 weeks before treatment begins. 5. ability to participate psychologically and physically, able to give informed consent and complete assessments, and participate in study procedures. exclusion criteria: 1. current psychotic disorders 2. current suicidal or homicidal ideations 3. current substance dependence other than alcohol or nicotine dependence 4. legal charges pending with potential of incarceration 5. unstable serious medical conditions or one requiring acute medical treatments or anticipation of hospitalization for extended care

Keywords: alcohol dependence ptsd cpt-c
study to evaluate the safety, immunogenicity, and efficacy of nanocovax vaccine against covid-19

Conditions: SARS-CoV-2 Infection; COVID-19

Summary: the purpose of this study is to evaluate the safety, immunogenicity, and efficacy of nanocovax vaccine in volunteer subjects 18 years of age and older.

this is a phase 3, adaptive, multicenter, randomized, double-blind, placebo control study to evaluate the safety, immunogenicity, and efficacy of the nanocovax vaccine against covid-19 in volunteer subjects 18 years of age and older. age stratified as 18-45, 45-60, and \> 60 years of age. the assessment of immunogenicity will be further expanded in a subset of phase 3 (1000 participants). randomly assigned to vaccine or placebo group with a ratio of 2:1 (2 subjects injected with nanocovax 25 mcg : 1 subject injected with placebo).

Eligibility criteria:
inclusion criteria: * be a male or female 18 years of age or older. * for females: be of non-childbearing potential or willing to use appropriate contraceptive measures for 30 days prior to vaccination through 6 months after completion of the vaccine series. * willingness to provide a signed, printed, and dated informed consent form. * able and willing to participate in all activities in the clinical trial. * participants with hiv, hbv, hcv should have a health record, determined to be stable for 6 months prior to the screening. exclusion criteria: * participants with unstable pre-existing medical conditions over the three months before enrollment (condition that has worsened to require hospitalization or significant changes in therapy). * planned administration/administration of a vaccine not foreseen by the study protocol from within 45 days before the first dose of study vaccine. * previous vaccination with any covid-19 vaccine. * history of covid-19 disease. * history of allergic reactions or anaphylaxis to previous immunizations or allergies to any components of the vaccine. * planning to become pregnant or planning to discontinue contraceptive precautions during the vaccination phase through 6 months after the second immunization. * history of bleeding disorders/hemostasis or use of anticoagulants. * currently having cancer or undergoing cancer treatment. * chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within 3 months prior to the first vaccine dose (inhaled and topical steroids are allowed). * women who are pregnant or breastfeeding.
functional pathologies of the musculoskeletal system in physiotherapy students

Conditions: Low Back Pain, Postural

Summary: this study map the occurrence of functional pathologies of the musculoskeletal system in students of the bachelor's program of physiotherapy of the third faculty of medicine, charles university, and aim on improvement of them.

the aim of this study is to map the occurrence of functional pathologies of the musculoskeletal system in students of the bachelor's program of physiotherapy of the third faculty of medicine, charles university, and to examine their postural functions. another goal is to teach the students of the experimental group how to remove functional pathologies of the musculoskeletal system and how to change their motor behaviour and postural functions so that the development of functional disorders no longer occurs.

Eligibility criteria:
inclusion criteria: * bachelor's study of physiotherapy at the third faculty of medicine, charles university * the presence of functional pathologies of the musculoskeletal system (verification by means of trigger points) exclusion criteria: * serious cardiovascular or orthopedic dysfunction * neurological disease * reduced cognitive functions complicating examination and subsequent therapy

Keywords: trigger point pain, myofascial motor activity physiotherapy
preoperative immunonutrition in laparoscopic total d2 gastrectomy

Conditions: Gastric Cancer; Surgery; Laparoscopic; Gastric Neoplasm; Digestive Cancer

Summary: immunonutrition (in) appears to reduce infective complications and in-hospital length of stay (los) after gastrointestinal surgery. more specifically, it seems to be beneficial also in gastric cancer surgery. potential benefits of combining preoperative in (pin) with protocols of enhanced recovery after surgery (eras) in reducing los in laparoscopic total gastrectomy are yet to be determined.


Eligibility criteria:
inclusion criteria: * age \>18 years * primary gastric cancer * preoperative staging i-iii * eligible for laparoscopic d2 total gastrectomy exclusion criteria: * acquired or congenital immunodeficiency * malnutrition (mna-sf score \< 12) * preoperative infection * previous gastric surgery * asa iv * emergency setting * para-aortic node involvement * intraoperative evidence of distant metastasis or peritoneal carcinosis * conversion to open surgery
evaluation of gore® viabahn® endoprosthesis for popliteal artery aneurysm

Conditions: Popliteal Artery Aneurysm

Summary: this is a multicenter, non-randomized, single arm, retrospective study of gore® viabahn® endoprosthesis for the treatment of a popliteal artery aneurysm (paa).

the primary objective is to evaluate the safety and efficacy of the gore® viabahn® endoprosthesis for the treatment of subjects with popliteal artery aneurysms. the study population includes subjects with an asymptomatic aneurysm (≥ 2 cm diameter) of the popliteal artery, symptomatic aneurysm (no diameter requirement) of the popliteal artery, or presence of mural thrombus (no diameter requirement) of the popliteal artery treated with the gore® viabahn® endoprosthesis between january 1, 2002 and december 31, 2010. starting with most recently treated within the above date range, patients meeting inclusion/exclusion will be enrolled, until a minimum of 50 subjects with adequate follow up to determine primary endpoints through 12 months will be provided.

Eligibility criteria:
inclusion criteria: * received a gore® viabahn® endoprosthesis between january 1, 2002 and december 31, 2010 to treat a popliteal artery aneurysm; * had an asymptomatic aneurysm (≥ 2 cm diameter) of the popliteal artery, or symptomatic aneurysm (no diameter requirement) of the popliteal artery, or the presence of mural thrombus (no diameter requirement) of the popliteal artery; * was 18 years of age or older; and * had an elective popliteal artery aneurysm procedure. exclusion criteria: * bilateral popliteal artery aneurysms with initial treatment on the same day * had previous surgery for the popliteal artery aneurysm in the study limb

Keywords: popliteal artery aneurysm popliteal artery aneurysm asymptomatic aneurysm mural thrombus viabahn gore endoprosthesis
assessment of physical activity among juvenile idiopathic arthritis children performed with actigraphy

Conditions: Juvenile Idiopathic Arthritis

Summary: this study aims to describe physical activity among juvenile idiopathic arthritis children, according to the disease's and patient's characteristics.


Eligibility criteria:
inclusion criteria: * juvenile idiopathic arthritis evolving for more than a year exclusion criteria: * intra-articular infiltration performed less than a month ago