Kornimate/medical-research-clean huggingface dataset:
lifestyle intervention for cardiovascular disease risk factors among female residents at the national guard residential city, jeddah, saudi arabia

Conditions: Cardiovascular Diseases

Summary: cardiovascular disease (cvd) remains the major cause of mortality globally. applying a comprehensive interventional program based on the individual's risk may reduce the incidence and complications of cvd; thus, helping to decrease the burden on the healthcare system. this study compared the effects of a 3-month intervention involving lifestyle modification and physical activity with standard care in women ≥30 years having a moderate-to-high risk of cvd, with respect to improving physical activity and cardiovascular disease risk factors at the national guard residential city in jeddah, saudi arabia, in 2015. the effects of this community-based lifestyle program were assessed through a randomized controlled trial. women in the intervention group (n=31) received health education, exercise training, and diet counselling as individuals and in groups according to the participant's risk. women in the control group (n=28) received one health education session at the screening site. the framingham risk score (frs) was calculated at baseline and at 3 months for both groups. the mean participant age was 42±8 years.


Eligibility criteria:
inclusion criteria: 1. women aged ≥ 30 years. 2. the participants must be at moderate to high-risk of cvd according to frs. exclusion criteria: 1. women aged \< 30 years. 2. women aged ≥ 30 years with low risk of cvd according to frs. 3. pregnant women. 4. female patients diagnosed with cvd.

Keywords: cardiovascular diseases, framingham risk score, life style modification, randomized controlled trial
two bed spect/ct versus planar bone scintigraphy in detection of osseous metastases in patients with genitourinary malignancies

Conditions: Bone Metastases; Urogenital Cancer

Summary: the study aims to compare the diagnostic performance of planar bone scan and two bed spect/ct in detection of bone metastases in patients with urogenital cancer.

genitourinary malignancies represent a heterogeneous group of diseases linked by anatomical and physiological function. renal cell carcinoma (rcc); urothelial carcinoma of the bladder, ureter, and renal pelvis, and prostate adenocarcinoma (pc) are the most commonly encountered histological subtypes within this group. planar bone scintigraphy (pbs) with di-phosphonate compounds is widely used, cost-effective and sensitive imaging modality for detecting osseous metastases especially in prostate cancer. however, it suffers from low specificity as well as low sensitivity in purely osteolytic lesions. single-photon emission computed tomography (spect) is a three-dimensional acquisition method that has demonstrated greater sensitivity and specificity compared to planar images, especially for detecting vertebral metastases. the introduction of spect/ct images improves the lesion-to-background ratio, allows anatomic lesion localization, removes the superimposition of anatomical structures, such as urinary bladder activity, and provides anatomical data, thereby increasing the sensitivity, specificity and positive predictive value of bone scan. as the technology advances, current spect/ct machines have become capable of sequentially covering, and accurately merging, more than one field of view (fov) in a reasonable time. in this study, we aim to compare the diagnostic performance of two-bed spect/ct images and planar bone scintigraphy in detection of bone metastases in genitourinary malignancies.

Eligibility criteria:
inclusion criteria: * adult patients with urogenital cancer referred for bone scan. exclusion criteria: * patients with claustrophobia. * patients refuse to do the scan. * patients with relative or absolute contraindications to do the scan (eg. pregnancy).

Keywords: bone scintigraphy
study to evaluate the safety, pharmacokinetics and tolerability of bms-708163

Conditions: Alzheimer's Disease

Summary: the primary objective is to assess the safety and tolerability of a single oral dose of bms-708163 in healthy young male subjects and in elderly male and female subjects.


Eligibility criteria:
inclusion criteria: * panels 1- 8 and panels 14-15: healthy male subjects between the ages of 18 to 45 * panels 9 and 10: healthy elderly males and females ages 60 and greater * panel 11: healthy males between the ages of 46-59 * panel 12: males and/or females either healthy or with mild cognitive impairment (mci) between the ages of 60 and 74 * panel 13: males and/or females, healthy or with alzheimer's disease (ad) or mci that were 75 years of age or greater * acceptable medical history, physical examinations, vital signs, electrocardiograms, hemoccult stool tests, and clinical laboratory evaluations
breakfast for female adolescent - newstart

Conditions: Overweight Adolescents; Metabolic Disease

Summary: investigators will test the long-term health effects of eating a dairy-based protein-rich breakfast and/or performing regular physical training for 12 weeks in 100 previous 'breakfast skipping' young overweight women (2 x 2 factorial design). measurements of body composition, physical fitness, metabolic health parameters, faeces (microbiota activity and composition), satiety and daily energy intake will be collected.

the study is a 2×2-factorial randomized controlled trial with 4 study arms. the subjects will be randomly allocated to skip breakfast or eat high-protein yoghurt products (300g/day) and to either exercise 3x per week or maintain habitual physical activity for 12 weeks. measurements and biological sampling will be performed at baseline and at the end of the intervention period. the primary outcome will be fat mass and fat free mass. the investigators will also measure effects on weigth, waiste, health-related blood paramenters, muscle function, metabolites in urine and blood, and gut microflora and ph.

Eligibility criteria:
inclusion criteria: * bmi \>25 * exercising \< 1 h per week. exclusion criteria: * smoking * illness and use of medication affecting the study outcomes * allergy towards milk and yoghurt * weightloss/gain \>5kg the last 6 months * dieting * eating disorder * pregnancy * breast feeding * unable to speak and understand danish
trial of erlotinib with or without pf-3512676 in advanced non small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to assess the efficacy and safety of pf-3512676 administered in combination with erlotinib in patients with advanced egfr-positive non-small cell lung cancer after failure of at least one prior chemotherapy regimen.


Eligibility criteria:
inclusion criteria: * advanced, egfr-positive nsclc * ecog performance status 0, 1 or 2 * measurable disease exclusion criteria: * known cns metastasis * pre-existing autoimmune or antibody mediated disease

Keywords: advanced carcinoma non-small cell lung egfr positive erlotinib tarceva pf-3512676 phase ii immunotherapy immune modulator
erector spinae plane block for postoperative pain management

Conditions: Pain; Post Operative Pain

Summary: erector spinae plane (esp) block is an interfacial plane block with visceral and somatic analgesic activity at paraspinal muscles. this study aims to examine the postoperative analgesic efficacy of esp block after cesarean section (cs) with pfannenstiel incision under spinal anesthesia.

the study included 54 patients with mild systemic disease (asa ii patients) who would undergo elective cs under spinal anesthesia. they were randomly divided into an esp block group (group e) and a control group (group c). after the surgery, group e patients underwent ultrasound-guided bilateral esp block with 20 ml of 0.25% bupivacaine at the lateral decubitus position, while group c received no intervention. patients in both groups received parenteral patient-controlled analgesia. the patients' post-operative 24-hour opioid consumption, regular visual analogue scale (vas) measurements, and need for rescue analgesics were evaluated. statistical analysis was performed using spss 21 program. demographic and other data were assessed using independent samples t-test, mann-whitney u test, and chi-square analysis.

Eligibility criteria:
inclusion criteria: * asa ii patients * 18-45 years who underwent cs with pfannenstiel incision under spinal anesthesia * agreed to participate in the study exclusion criteria: * patients with infection at the injection site * coagulopathy allergy to amide-type local anesthetics * history of peripheral neuropathy * hepatic and/or renal failure * refusing the procedure * patients with heart disease

Keywords: pain postoperative analgesia erector spinae plane block cesarean section
preventing childhood antibiotic-associated diarrhea by prebiotics

Conditions: Antibiotic-Associated Diarrhea

Summary: prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.

group will get either the product or placebo blindly throughout antibiotic treatment with additional 14 days.

Eligibility criteria:
inclusion criteria: * healthy children with acute infection. exclusion criteria: * hypersensitivity to antibiotics, chronic illness.

Keywords: prebiotics antibiotic-associated diarrhea
contingency management for alcohol use disorders

Conditions: Alcohol Use Disorder; Contingency Management

Summary: contingency management (cm) treatments are highly efficacious in improving outcomes of substance abusing patients. however, cm has rarely been applied to individuals with alcohol use disorders, primarily because of technological limitations in monitoring drinking. the secure continuous remote alcohol monitor (scramx®) is a new technology designed to continuously monitor alcohol consumption 24 hours a day for 7 days per week. the purpose of this study is to evaluate the efficacy of cm in reducing alcohol use using scramx. in total, 120 alcohol abusing or dependent patients initiating outpatient treatment at community-based clinics will be randomly assigned to one of two conditions: standard care, or standard care plus cm with reinforcement based on results of scramx readings. compared with standard care, it is expected that cm will result in fewer drinking days and longer durations of continuous non-drinking days.


Eligibility criteria:
inclusion criteria: * age 18 years or older * current diagnosis of alcohol use disorder and self report of recent alcohol use * pass an informed consent quiz * agree to wear a scramx monitor for 12 weeks * have a standard scramx compatible phone line in their home or agree to attend the clinic weekly for brief research visits/downloads * agree to sign an off-campus property transfer form and return scramx equipment exclusion criteria: * serious, uncontrolled psychiatric illness * in recovery from pathological gambling * have an unstable address * intend to participate in activities incompatible with scramx over the next 3 months * are wearing scramx for legal purposes
an observational study to assess the quality of life of the patients with multiple sclerosis and their caregivers

Conditions: Multiple Sclerosis

Summary: this is an observational, non controlled, non-interventional, multicentric, prospective study planned to be conducted in 450 subjects diagnosed with ms and their caregivers in 20 centres of argentina. the observations from this study will contribute to the awareness of the impact on the quality of life (qol) of the caregivers and, eventually will also provide measures for helping the subjects with multiple sclerosis (ms) without leaving aside the care of the physical and psychic health of those who work as caregivers.

caregivers of subjects diagnosed with ms have to take care of many activities of ms subjects that they cannot perform themselves, because of their lack of autonomy. the fact of aiding a person with some degree of disability due to a chronic disease in an intense way and for a long time could generate a high level of satisfaction in the caregiver; but at the same time the emotional and physical exhaustion of the caregiver increases as the disease progresses. the qol of the person who is emotionally bonded to the ms subject as a caregiver has a great chance to be affected; and this is for sure more likely than in the case when the caregiver is a hired professional. objectives primary objective: * to identify the impact of ms on the qol of the ms subjects and their caregivers secondary objectives: * to establish the correlation between the qol of the subjects with ms and their caregivers * to identify the predictors of the qol in the caregiver group this is an observational, prospective and non-interventional study planned to be conducted in 20 centers in argentina. the subjects with diagnosed ms will be managed with the clinical and therapeutic elements that their treating doctors considered appropriate, without modifying their decisions due to the subjects' inclusion into the study. the caregivers will be asked to complete the qol questionnaire as a part of the normal interview on each and every visit. the total duration of the study is 24 months. a descriptive analysis will be performed for the demographic and clinical characteristics of the investigation subjects, as well as for the characteristics of the treatments they receive when they start their participation in this study. for the qualitative variables, treatment modifications, frequency tables and the percentages will be performed.

Eligibility criteria:
inclusion criteria: * ms subjects and their caregivers, \>21 years of age of both sexes * subjects who have signed informed consent * subjects with established ms diagnosis according to the revised mc donald criteria - 2005 with at least 1 year of evolution * subjects with ms that have an identified caregiver exclusion criteria: * subjects with other(s) associated neurological, psychiatric or systemic disease(s)

Keywords: multiple sclerosis sclerosis quality of life
transcranial direct current stimulation to reduce chronic pain in patients with chronic inflammatory bowel diseases

Conditions: Inflammatory Bowel Disease

Summary: in the study we test whether transcranial direct current stimulation can reduce the perception of pain in patients with chronic inflammatory bowel diseases. hypothesis: transcranial direct current stimulation can reduce the perception of pain in patients with chronic inflammatory bowel diseases.


Eligibility criteria:
inclusion criteria: * inflammatory bowel disease * chronic pain (more than 3 months) * pain (vas \> 3/10) exclusion criteria: * contraindication to transcranial direct current stimulation * pregnancy * sever internal or psychiatric condition
women's lifestyle balance study

Conditions: PreDiabetes; Metabolic Syndrome; Overweight

Summary: this pilot study aims to determine whether adding a sleep extension and sleep hygiene intervention to an existing lifestyle improvement program improves its efficacy for weight loss in those at risk for diabetes and cardiovascular disease. half of the participants will receive the centers for disease control's standard preventt2 program and half of the participants will receive the same program with an additional sleep intervention.

the goal of this pilot study is to determine whether the efficacy of an existing lifestyle improvement program can be increased by adding a sleep extension and sleep hygiene intervention. improved sleep can improve weight loss through two possible routes: lessening fatigue may potentiate physical activity (pa), and decreasing appetite may potentiate diet improvements. a sample of 24-30 women will be assigned to either the centers for disease control's (cdc's) standard preventt2 program or the same program with an additional integrated sleep intervention. both programs will involve 8 group sessions administered over 3 months, and all women will be followed for a total of 6 months. the primary outcome is weight loss, and secondary outcomes include sleep quality and duration, physical activity, caloric intake, and physiological indicators of cardiovascular and diabetes risk (hba1c, homa-ir, lipids, blood pressure). the combined program has the potential to significantly improve weight loss in those at risk for diabetes and cardiovascular disease (cvd).

Eligibility criteria:
inclusion criteria: * female (or self-identify as female) * age 30-70 years * bmi 25-38 (or 23-38 if asian or other pacific islander) * time in bed \<= 7 hours on a typical weeknight * meets diagnostic criteria for prediabetes and/or metabolic syndrome exclusion criteria: * no regular access to telephone or email (for maintaining contact); * no access to smartphone, tablet, or laptop computer (for using fitbit); * having a condition that limits physical activity, such as brisk walking; * having a diagnosis of type 1 or type 2 diabetes or been previously treated with diabetes medications; * having a cardiac event or cardiac surgery in the past year; * having a metabolic condition that prevents weight loss; * working night shift (midnight - 4 am) * inability to complete the baseline assessment (redcap survey and fitbit tracking of activity, diet, and sleep for 7 days)

Keywords: weight loss women sleep intervention diet physical activity fitbit
transtheoretical model of behavior change and anxiety

Conditions: Psychological; Physical Activity

Summary: examine the utility of the transtheoretical model in influencing anxiety among college students. employ a randomized controlled intervention including a static and dynamic facebook intervention. the static group accessed a facebook page featuring 96 statuses. statuses were intended to engage cognitive processes, followed by behavioral processes of change per the transtheoretical model of behavior change. content posted on the static facebook page was identical to the dynamic page. however, the static group viewed all 96 statuses on the first day of the study, while the dynamic group received only 1-2 of these status updates per day throughout the intervention. anxiety was measured using the overall anxiety severity and impairment scale (oasis). time spent engaging in physical activity was assessed using the international physical activity questionnaire (ipaq).


Eligibility criteria:
inclusion criteria: * having an active facebook account * daily access to a smart phone * current university of mississippi email account exclusion criteria: * outside the age range of 18-35
effects of paroxetine on cardiovascular function in septic patients

Conditions: Septic Shock; Sepsis

Summary: it is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with no being an important mediator of this organ dysfunction. data in the literature have shown that hyporeactivity to catecholamines is associated with a decrease in the density of α and ß receptors in the aorta and heart, respectively, as well as an increase in grk2 levels and that no contributes to the increase of this kinase in sepsis . based on this, it is hypothesized that cardiac dysfunction and decreased peripheral vascular resistance observed in sepsis may result from an increase in grk2 activity and/or expression and its inhibition may be a relevant therapeutic target in septic shock patients. based on this line, a measurable clinical benefit of paroxetine through the regulation of grk2 expression in patients with septic shock is postulated.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age; * patient diagnosed with septic shock for less than 48 hours and using a minimum dose of noradrenaline (0.01 mcg/kg/min); * patients and/or legal guardians who consented to participate in the study through the free and informed consent term before randomization. exclusion criteria: * pregnant women; * patients with inability to use the gastrointestinal tract; * patients with known intolerance to paroxetine and/or fluoxetine; * patients on concomitant use of medications that may potentiate the occurrence of serotonin syndrome (tramadol, citalopram, escitalopram, sertraline, desvenlafaxine, venlafaxine, duloxetine, sibutramine, bupropion, amitriptyline, nortriptyline, lithium); * patients in end-of-life care or with an expected survival of less than 24 hours at the time of eligibility
multi-parametric breast ultrasound imaging as a potential biomarker for breast cancer

Conditions: Breast Cancer

Summary: it is studied whether multi-parametric biomarkers such as speed-of-sound imaging or others, applied during breast ultrasound (bus) imaging allows to classify lesions according to its malignancy. the standard reference intervention is bus guided biopsy or the consensus of the board of experts judging the bus imaging results if no biopsy is done.

patients with a palpable lump in the breast or suspicious findings in x-ray mammography typically undergo breast ultrasound examination as a supplemental imaging modality. findings are then used for tumour classification according the american collage of radiology (acr) breast imaging reporting and database system (bi-rads) lexicon. suspicious findings then undergo ultrasound-guided biopsy, which causes discomfort for the patient and introduces high emotional stress, and may involve - albeit very-small - risk of complications (such as bleeding and infections). today conventional breast ultrasound b-mode images do not have the specificity to reliably differentiate malignant and benign tissues in all cases and hence a biopsy intervention or close follow-up is necessitated. multiparametric imaging bio-markers such as the novel method of speed-of-sound imaging may provide additional indicators to help to better classify lesions prior to biopsy and avoid any further work-up. the study collects data with an ultrasound device during normal bus examination which is then retrospectively processed to extract the desired multi-parametric bus (mp-bus) information of imaged tissue.

Eligibility criteria:
inclusion criteria: * women who are suspected or suspected of having breast cancer and who are advised to perform a detailed breast ultrasound or tissue sampling (biopsy) * classification into groups: * group 1: foreseen for bus guided biopsy * group 2: bi-rads classification i, ii and iii and foreseen for bus only based diagnosis exclusion criteria: * lactating women * women with mastitis * vulnerable persons