Kornimate/medical-research-clean huggingface dataset:
minimally invasive surgery vs. endoscopy randomized (miser) trial for necrotizing pancreatitis

Conditions: Necrosis of Pancreas; Infected Pancreatic Necrosis

Summary: prospective, randomized controlled trial comparing endoscopic ultrasound (eus) guided cystogastrostomy or cystoduodenostomy and endoscopic necrosectomy to minimally invasive surgical necrosectomy, in patients with necrotizing pancreatitis.

patients will be randomly allocated to either treatment arm in a 1:1 ratio. following intervention, patients will be assessed at regular intervals until study completion at 6 months post-discharge. primary outcome is a composite of major complications and/or mortality, measured to 6 months post-discharge.

Eligibility criteria:
inclusion criteria: * necrotic collection * infected (suspected and confirmed): clinical signs of infection (septic, positive cultures, febrile), systemic inflammatory response syndrome, gas within the collection on imaging (not iatrogenic), or positive culture of collection contents * necrotic collection is within 15mm of the lumen of the gastrointestinal tract. * 18 years and older * informed consent obtained from the patient or their medical representative. * medically fit for general anesthetic * collection amenable to either endoscopic or minimally invasive surgical necrosectomy and drainage. exclusion criteria: * \<18 years old * unable to obtain informed consent from the patient or their medical representative. * medically unfit for general anesthesia * pregnant * necrotic collection not accessible by either or both techniques * the collection is \>15mm from the lumen of the gastrointestinal tract. * irreversible coagulopathy: international normalized ratio (inr) \>1.5 * irreversible thrombocytopenia: platelet count \<50 x10\^9/l * dual antiplatelet therapy or therapeutic anticoagulation that cannot be withheld for the procedure * surgical or endoscopic necrosectomy or pseudocyst drainage has been performed within the preceding 12 months * necrotic collection secondary to trauma or other surgical event that requires additional interventions such as management of liver lacerations or vascular injury. * pre-existing percutaneous drain

Keywords: symptomatic infected necrotic collection
airway macrophages and sputum milieu in adult subjects with airflow obstruction

Conditions: Pulmonary Disease, Chronic Obstructive; Bronchitis, Chronic; Occupational Diseases; Tobacco Use Disorder

Summary: airway macrophage impairment is a central feature in the immunopathogenesis of chronic obstructive pulmonary disease, regardless of smoking status.

in the united states, a variety of farming operations can generate significant amounts of dust. chronic organic dust exposure to workers in this industry can result in several respiratory health conditions including chronic bronchitis, chronic obstructive pulmonary disease (copd), and exacerbations of asthma. organic dust is a complex mixture containing particulate matter and microbial-associated components from gram positive and gram negative bacteria. airway macrophages are key innate immune cells that are rapidly activated by exposure to inhaled toxins and organic dust. the literature indicates that subjects with tobacco-induced chronic bronchitis/copd have alveolar macrophages that have impaired function. it has been hypothesized that the impaired lung macrophage function may contribute to the increased susceptibility to infections and chronic bacterial colonization that is a central feature in subjects with chronic bronchitis/copd. it is unknown at this time if impaired macrophage function is secondary to tobacco-induced effects, or is a central pathologic feature of chronic bronchitis/copd. we will explore the expression of innate immune cell surface molecule expression involved in antigen presentation, phagocytic ability, and ex vivo cytokine responses in airway macrophages obtained by induced sputum. we will also collect blood to determine if ex vivo stimulation of blood mimics the inflammatory responses observed with airway macrophages. comparisons to our past findings in vitro studies, which demonstrated that repetitive organic dust exposure impairs monocyte derived macrophage immune cell surface markers and function, could then be made. this information could lead to future investigations centered on therapeutic interventions to prevent or reverse the underlying lung disease experienced by farmers in this industry.

Eligibility criteria:
inclusion criteria: * medically stable to participate in induced sputums * group one: smoked less than 100 cigarettes in their lifetime quit smoking greater than 10 years ago pre-bronchodilator fev1/fvc \> 70% pre-bronchodilator fev1 % predicted \> 80% * group two: greater than a 20-pack year tobacco history smoked in the last two years post-bronchodilator fev1/fvc \< 70% * group three:have less than a 20-pack year tobacco history quit smoking greater than 20 years ago post-bronchodilator fev1/fvc \< 70% exclusion criteria: * personal history of lung cancer * pregnancy * personal history of autoimmune disease * currently taking oral/parental corticosteroids * personal history of upper or lower respiratory tract infection in the prior four weeks

Keywords: pulmonary disease, chronic obstructive airway macrophages sputum milieu airway inflammation occupational diseases
safety of inhaled insulin with type 1 and type 2 diabetes

Conditions: Diabetes, Type 1; Diabetes, Type 2

Summary: pulmonary safety in diabetics with t/i


Eligibility criteria:
inclusion criteria: * for all subjects: * nonsmoking * body mass index \<42 kg/m2 * fev1 greater than or equal to 70% of predicted , dlco and tlc greater than or equal to 80% of predicted at screening, * no abnormalities in screening pulmonary radiology * for subjects with diabetes mellitus: * type 1 or type 2 diabetes for at least 2 years * hba1c greater than or equal to 6.6 % and less than or equal to 12.0 % * for subjects without abnormalities in glucose control: * no history of diabetes * normal results from a formal glucose tolerance test exclusion criteria: * history of chronic obstructive pulmonary disease, asthma, or other significant pulmonary disease * significant renal, hepatic, or cardiac disease * women who are pregnant, lactating, or planning on becoming pregnant * subjects who have participated in studies of other investigational drugs within the previous 3 months * evidence of severe complications of diabetes
circular rna and chemerin in breast cancer patient

Conditions: Breast Cancer

Summary: this study aimed to evaluate the role of serum chemerin as a biomarker of breast cancer. and to investigate the diagnostic value of hsa_circ_0001785 (circ-elp3) and hsa_circ_100219 (circ-faf1) in serum samples of breast cancer patients to find out whether these circrnas can utilize as a diagnostic and prognostic biomarker for human breast cancer assessment and make correlation between serum chemerin levels , serum circ-faf1 , serum circelp3 and classical tumor markers (cea + ca15-3). andto elucidate if there is a difference between metastatic and non-metastatic cases as regard serum chemerin levels, serum circ-faf1 or circ-elp3.

breast cancer is the most common cancer among women and despite advances in therapy over the past few decades, drug resistance, recurrence, metastasis and the heterogeneity of the cancer continue to be a problem in successful management of the diseases(hong et al ,2019) . circular rnas (circrnas) are single-stranded, covalently closed rna molecules that are ubiquitous across species ranging from viruses to mammals(zhou et al 3 .,2020). circrnas can be divided into two categories including coding and noncoding circrnas(li et al., 2019) a new subtype of rnas is circular rnas, single-strand rna molecules with less than 100 to more than 4,000 nucleotides (lu et al., 2016) and a covalently closedloop structure. these molecules are produced through a backsplicing mechanism, in which the downstream 5'-end of the splice donor joins the upstream 3'-end splice acceptor and forms a product with a circular structure (wang et al., 2017). chemerin is a leukocyte chemoattractant widely expressed in many tissues and is known to recruit innate leukocytes. recently, more and more studies focus on the relationship between chemerin and cancers and found that chemerin acts an essential role in cancers.(shin et al,2018) chemerin expression is different depending on the tumor type (zhang y et al, 2013) the clinical significance of chemerin in breast cancer has been only reported by a very limited number of studies (el sagheer et al,2018).

Eligibility criteria:
inclusion criteria: * histopathological diagnosis of breast cancer exclusion criteria: * history of other types of cancers * history of hiv * history of any therapeutic interventions in form of chemo or hormonal therapy before specimen collection
kinesio taping for finger injuries

Conditions: Finger Fracture; Finger Sprain; Ligament Injury of the Finger; Proximal Interphalangeal (PIP) Joint Injury

Summary: this study is a prospective, randomized controlled trial evaluating the effectiveness of three conservative treatment approaches-kinesio taping (kt), buddy taping (bt), and static splinting-for managing finger ligament injuries and non-displaced fractures. a total of 175 patients between the ages of 5 and 60 were randomly assigned to one of the treatment groups and monitored over a 3-month period. the study aims to assess outcomes including range of motion (rom), grip strength, pain levels, and functional recovery using the quickdash questionnaire.

finger ligament injuries and non-displaced fractures are common conditions encountered in both pediatric and adult orthopedic populations. conservative treatment options such as buddy taping and splinting are commonly employed in clinical practice, although each method may affect mobility and patient comfort differently. this randomized controlled trial was conducted to evaluate three conservative treatment modalities-kinesio taping (kt), buddy taping (bt), and static volar splinting-in patients aged 5 to 60 years. participants were randomly assigned to one of the three treatment groups and evaluated at three time points: day 3, week 3, and month 3. the primary outcome measure was the range of motion of the injured finger. secondary outcomes included grip strength, pain scores, quickdash assessments, and incidence of skin-related complications. outcome evaluations were performed by an independent orthopedic surgeon who was blinded to group assignment. patients were stratified into pediatric and adult subgroups to assess age-related differences in treatment response. the study followed a parallel assignment design and employed single-blind outcome assessment.

Eligibility criteria:
inclusion criteria: * age between 5 and 60 years * presentation within 5 days of injury * acute finger ligament sprain or non-displaced finger fracture (pip or phalangeal) * ability to provide informed consent (or parental consent for minors) * availability for 3-month follow-up exclusion criteria: * open fractures * polytrauma or systemic injury * delayed presentation (\>5 days post-injury) * need for surgical fixation * previous injury or deformity in the same finger * neurological or rheumatologic disorders affecting hand function

Keywords: kinesio taping buddy taping conservative treatment quickdash grip strength range of motion non-operative hand fracture randomized controlled trial
high intensity physiotherapy for hip fractures

Conditions: Hip Fractures

Summary: every day, more than 40 australian break their hip, most are over the age of sixty five. hip fractures are a significant problem for the older people, the hospital system and community as a whole because of the increasing numbers of fractures and the cost of hospitalisation and ongoing care. after one year, less than half of all people with a hip fracture can walk as well as they did before the fracture. physiotherapy in the acute hospital setting is an integral part of patient care, although the intensity of physiotherapy a patient receives is variable and the optimal number of treatment sessions per day remains unknown. studies in other patient groups have shown that increased physiotherapy can improve patient outcomes by increasing muscle strength and mobility. it can also reduce the negative effects of bed rest such as muscle wasting, blood clots in the lungs or leg veins and chest infections such as pneumonia. this study aims to investigate the effectiveness of an intensive physiotherapy program in hip fracture patients to further understand this and the effect it has on patient function. in this research the investigators will randomly allocate patients into 2 groups; usual care and intensive physiotherapy. the usual care group will have physiotherapy treatment daily whereas the intensive physiotherapy group will have an additional daily treatment by a physiotherapist as well as a daily treatment by an allied health assistant. the objectives are to achieve better functional outcomes in the patient's hospital stay (ie improved mobility), reduce the time for patients to be physically ready to go home, increase the number of patients able to go directly home or to fast stream rehabilitation (rather than a slow stream option). if increased intensity of physiotherapy is found to improve patient's mobility outcomes, this research will provide the confidence to endorse a change to current clinical practice.


Eligibility criteria:
inclusion criteria: * admission to the alfred with an isolated hip fracture and treated with internal fixation, aged 65 or above exclusion criteria: * fracture is in the sub-trochanteric region of the femur, * if it is pathological, * if post operative orders are for non-weight bearing on the operated hip, * if they were unable to mobilise independently (or with gait aid) prior to admission, * or if they were admitted from a nursing home.
monitor-ckd5 - multi-level evaluation of anaemia treatment, outcomes, and determinants in chronic kidney disease stage 5

Conditions: Chronic Kidney Disease; End-stage Renal Disease; Anaemia

Summary: monitor-ckd5 is an observational, pharmaco-epidemiological study to evaluate the multi-level factors and outcomes associated with the treatment of renal anaemia with biosimilar epoetin alfa in stage 5 ckd patients requiring haemodialysis.

see the following publication: gesualdo, l., london, g., turner, m., lee, c., macdonald, k., covic, a., zaoui, p., combe, c., dellana, f., muenzberg, m., \& abraham, i. (in press). a pharmacoepidemiological study of the multi-level determinants, predictors, and clinical outcomes of biosimilar epoetin alfa for renal anemia in hemodialysis patients: background and methodology of the monitor-ckd5 study. internal and emergency medicine. (doi 10.1007/511739-011-0622-7)

Eligibility criteria:
inclusion criteria: * male or female adults (age \> 18 years). * on chronic haemodialysis due to end-stage renal disease (ckd5) of original or grafted kidneys for any duration. * diagnosed with renal anaemia; i.e., anaemia due to impaired production of endogenous erythropoietin secondary to kidney failure. * treated with commercially available intravenous epoetin alfa hexal® per physician's best clinical judgment and under consideration of available guidance and evidence. * female patients must be either post-menopausal for one year or surgically sterile or using effective contraceptive methods such as barrier method with spermicide or an intra-uterine device. oral contraceptive use is allowed. * informed written consent to participate in the study by patients or their legal guardian. exclusion criteria: * known sensitivity to epoetin alfa hexal® or any other esa. * solid or hematological neoplasia being treated with chemotherapy. * treatment with any myelosuppressant medications. * blood transfusion dependency. * history of pure red cell aplasia. * bleeding episode in 30 days prior to enrollment. * orthopaedic surgery in 30 days prior to enrollment. * patients with several medical condition(s) that in view of the investigator prohibits participation in the study. * patients with willfully negligent nonadherence to their haemodialysis, medication, nutrition, and/or other recommended treatment regimens. * use of any investigational agent in the 30 days prior to enrollment. * women of childbearing potential not using the contraception method(s) described above. * women who are breastfeeding.

Keywords: chronic kidney disease end-stage renal disease renal anaemia epoetin alfa
single-center study measuring osdi dry eye score in patients undergoing an anti-vegf induction protocol

Conditions: Macular Degeneration; Diabetic Macular Edema; Retinal Vein Occlusion

Summary: the purpose of this study is to assess the sensation of ocular dry eye symptom after an intravitreal injection of anti-vegf.

the recrutement of the patient is done during the inclusion of the patient by the nurses of the ophtalmological service of clermont-ferrand and confirm by an ophtalmologist of the service. a mesure of the osdi is done before the injection, then at 1 day, on week by a phone call. each of this mesures are done for the 2 other injections. before each of this injection, a clinical mesure is done by a lacrydiag: the atrophy of the meibomian glands, the non-invasive break-up time, interferometry, the heigh of the tear meniscum.

Eligibility criteria:
inclusion criteria: * patient with exsudative age-related macular degeneration, diabetic macular edema or retinal vein occlusion * patient with 3 ocular intravitreal injections of anti-vegf in one eye exclusion criteria: * pregnant or breastfeeding woman * intravitreal injection before the study * intravitreal injection in both eyes * allergy of betadine * guardianship patient
effectiveness of physiotherapy to treat the urinary incontinence and erectile dysfunction post retropubic prostatectomy

Conditions: Urinary Incontinence; Erectile Dysfunction

Summary: the prostate cancer is the most common parenchymal neoplasia in men over 45 years old. radical prostatectomy is curative treatment is most used today. urinary incontinence and erectile dysfunction are the main complications of radical prostatectomy. physical therapy has been used as a form of conservative treatment of these complications. however, the role of physiotherapy in the treatment of these complications is not well defined in the literature. we will do a randomized controlled study with patients undergoing radical prostatectomy. after removal of the foley catheter, patients will be randomized into 3 groups: control group, group of pelvic floor exercises and anal electrostimulation group. these patients will be evaluated preoperatively in an attempt to meet prognostic factors for urinary incontinence and erectile dysfunction. they will be followed by 2 years after surgery, to assess whether the therapy will alter the course of urinary continence and erectile function in these patients.

randomization was performed by a team of external statistics to the research team, using the method of randomization in blocks of three, who were randomly selected. the group to which the patient was allocated to researchers only be informed at the time of randomization, if patients satisfied the criteria for inclusion and exclusion. will be evaluated preoperatively: urodynamic studies and clinical evaluation. the following clinical data were evaluated: body mass index (bmi), comorbidities, disease staging and sociodemographic information. the following parameters will be evaluated in the pre-operative and after one, three, six and twelve months after surgery: evaluating the strength of the pelvic floor through perineometry, the 1 hour pad test, electromyographic evaluation of pelvic floor, and the application of instruments validated for the portuguese language. the follow instruments will be applied: international index of erectile function - 5 questions (iief-5), international consultation on incontinence questionnaire - short form (iciq-sf), international prostate symptom score (ipss).

Eligibility criteria:
inclusion criteria: * patients over 18 years * diagnosed with localized or locally advanced prostate cancer * that are undergoing radical prostatectomy as treatment of the condition * they are coming from barretos or a nearby region or has logistics facilities to come to the barretos cancer hospital to perform the followup exclusion criteria: * those with mental or physical problems that make it impossible to collect data or that may influence the recovery of continence postoperatively * patients with metastatic prostate cancer * patients not undergoing retropubic prostatectomy as treatment for prostate cancer

Keywords: urinary incontinence erectile dysfunction retropubic prostatectomy physiotherapy
nasal high-frequency jet ventilation (nhfjv) following extubation in preterm infants

Conditions: Infant,Premature; Respiratory Failure; Respiratory Insufficiency; Respiratory Distress Syndrome in Premature Infant

Summary: very low birth weight infants are at increased risk of requiring prolonged duration of mechanical ventilation and multiple intubations, both of which are risk factors for ventilator-induced lung injury and bpd. thus, it is important to investigate respiratory support methods that are able to effectively oxygenate and ventilate these high risk preterm infants while reducing their risk of lung injury. nasal high-frequency ventilation is one potential intervention that may decrease the risk of respiratory failure in very low birth weight infants. small studies have shown effective respiratory support over short time periods in infants, however these studies use nasal high-frequency oscillatory ventilation. to the investigators' knowledge there is no published studies looking at the use of nasal high-frequency jet ventilation in this high risk population. use of non-invasive high frequency ventilation (hfv) has been described as a rescue method following failure of other non-invasive ventilator modes or as a means to increase the success post-extubation. when used as invasive high frequency ventilation, high frequency oscillatory ventilation (hfov) or high frequency jet ventilation (hfjv) utilize supraphysiologic respiratory rates and small tidal volumes which has been shown to inflict less lung injury than conventional modes of ventilation. using a mechanical newborn lung model, nasal hfv has improved co2 removal when compared to conventional nippv. animal studies in the lab of kurt albertine have shown improved ventilation and oxygenation in the high frequency nasal ventilation group versus the mechanical ventilation group in a preterm lamb model leading towards better alveolar formation noted histologically. the investigators hypothesize that extubation of very preterm infants to nhfjv will significantly decrease the rates of reintubation compared to those infants extubated to nippv.


Eligibility criteria:
inclusion criteria: * 24 0/7 to 28 6/7 weeks ga * intubated within 24 hours of life to synchronized intermittent mandatory ventilation (simv) or high frequency ventilation (hfv, includes hfov or hfjv) * plan for extubation within 72 hours of life * infants intubated for surfactant replacement therapy via insure method (intubation-surfactant-extubation) are eligible * consent obtained from parent/legal guardian exclusion criteria: * major congenital and/or chromosomal anomalies * upper oropharyngeal anomalies

Keywords: non-invasive high frequency ventilation (nhfjv) nasal intermittent positive pressure ventilation (nippv)