Kornimate/medical-research-clean huggingface dataset:
individual nurse-led counselling programme for patients early discharged after myocardial infarction.

Conditions: Cardiovascular Diseases; Coronary Disease; Myocardial Infarction

Summary: the european guidelines of cardiovascular disease prevention recommend treatment modalities, such as lifestyle changes in order to minimize the risk of further cardiac event after a myocardial infarction (mi). however, a considerable gap exists between guidelines and their implementation in clinical practise. further, less is known about the impact of different interventions on patient's knowledge, skills and confidence necessary for self-management after mi. aim: to evaluate and compare the short- and long-term effects of an individual nurse-led counselling programme together with usual care for patients early discharged after mi on self-management behaviour.


Eligibility criteria:
inclusion criteria:patients with documented evidence of myocardial infarction during hospitalisation will be considered for inclusion. * patients over 18 years old * living at home in the local hospital area after hospital discharge * able to receive telephone calls, fill in questionnaire and communicate in norwegian. exclusion criteria: * cognitive impaired/dementia * planning for coronary artery bypass graft surgery

Keywords: practise patterns, nurses' directive counseling self care
effects of inhaled corticosteroids in the systemic inflammation induced by exercise in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is characterized by pulmonary and systemic inflammation. the effect of inhaled corticosteroids (ic) on inflammation in copd is controversial.

physical exercise produces a systemic inflammatory response, both in the healthy individual and in the copd patient (rabinovitch et al erj 2003; van helvoort et al respir med 2005; davidson wj et al. j appl physiol). nevertheless, although it has been described that some of the systemic biomarkers related with copd (protein c-reactive (pcr), interleukin \[il\]-8) are associated with a lower tolerance to exercise in copd patients (garcía-río et al. respir res 2010), the role of ic on systemic inflammation triggered by exercise in copd patients remains unknown. this study explores the hypothesis that the inflammatory response induced by exercise in copd patients could be with ic treatment.

Eligibility criteria:
inclusion criteria: * ex-smokers (\> 10 packets-year) with moderate-severe copd patients

Keywords: emphysema crp interleukin-8 dynamic hyperinflation
study evaluating severe surgical site infections (ssis) following contaminated or dirty-infected abdominal surgery

Conditions: Surgical Wound Infection; Postoperative Wound Infection

Summary: this is an observational study to evaluate the relative importance of the known risk factors for severe surgical site infections (ssis) on the development of the more severe ssi cases, and to describe the demographic, clinical features, etiology and the management and outcome of patients suffering from severe ssis in spain.

case and control study.

Eligibility criteria:
inclusion criteria: * age of or above 18 years. * admitted to a general surgery ward for elective or emergency abdominal surgery. * contaminated or dirty-infected surgical procedures. * only for cases, they will have to present symptoms and signs of a surgical site infection (ssi) (within 0-30 days) after abdominal surgery. * only for controls, patients must be free of ssi after 30 days from surgery, regardless of whether they are still in the hospital or being observed as an outpatient in the external clinic. exclusion criteria: * age under 18 years. * american society of anesthesiologist (asa) score of 5 or above. * surgical implant in place. * clean or clean-contaminated surgical procedures.

Keywords: surgical wound infection surgical site infection abdominal surgery
inflammasome activation and cortisol metabolism in obese women with recurrent miscarriage

Conditions: Obesity; Inflammation

Summary: the prevalence of obesity among women of reproductive age is increasing. obesity represents a chronic low-grade inflammatory state and nlrp3 inflammasome plays a pivotal role in obesity-induced inflammation. obesity is associated with an increased risk of recurrent miscarriage (rm), but the underlying mechanisms are unclear. abnormal inflammasome activation was also identified in the endometrium of women who experienced rm. given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and rm, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

pending

Eligibility criteria:
inclusion criteria: all women have conceived naturally without the aid of assisted reproductive technologies exclusion criteria: n/a
efficacy of a coaching program to promote physical activity and reduce sedentary behavior after a copd hospitalization

Conditions: Chronic Obstructive Pulmonary Disease; Physical Activity; Sedentary Lifestyle

Summary: patients with copd are more inactive and more sedentary than subjects of the same age and patients with other chronic diseases. this inactivity and sedentary behavior is accentuated after hospitalizations due to a copd exacerbation, and it increases the risk for future hospitalizations and mortality. therefore, there is a need for intervention to promote physical activity and to reduce sedentary behavior after these events. the present study aims to evaluate the efficacy of a coaching program to promote physical activity and reduce sedentary behavior in patients with copd who have suffered a hospitalization due to a copd exacerbation. sixty-six copd patients admitted to the hospital will be recruited during 18 months. physical activity, sedentary behaviors, as well as other clinical and functional parameters will be evaluated after hospital discharge. patients will be then randomized to an intervention and control group (1:1). the intervention group will receive an individualized coaching program. during a motivational interview an experienced physiotherapist will asses participant's usual exercise habits, possible barriers and facilitators, self-efficacy and motivation to increase physical activity and reduce sedentary time. based on these data (and baseline physical activity/sedentary information) an individualized, progressive program with specific goals setting and self-monitoring will be established (patients will be active participants and decision makers in this process). the control group will receive the usual care during follow-up. physical activity, sedentary behaviors, as well as the clinical and functional variables will be evaluated again at 12 weeks in both patients' groups.


Eligibility criteria:
inclusion criteria: 1. previous diagnosis of copd according to spirometric criteria (post-bronchodilator fev1 / fvc less than 70%) 2. smoking exposure\> 10 paq/year. 3. age greater than 40 years. 4. hospitalization due to a copd exacerbation 5. written informed consent. exclusion criteria: 1. patients needing the care of an intensive care unit. 2. patients who have been hospitalized more than once for a copd exacerbation in the previous 12 months (at least 3 months from last discharge). 3. patients with continuous oxygen therapy who do not have a portable source before admission. 4. patients with severe hypoxemia at rest (spo2 \<85% at rest) at discharge 5. mental incapacity, severe comorbidity, general fragility or advanced age that could substantially difficult patient's participation in the study. 6. patients who need mechanical aids for walking. 7. patients participating in a pulmonary rehabilitation program. 8. difficulty understanding spanish / catalan.

Keywords: copd physical activity sedentary behaviour hospitalization
an open label slv308 safety extension to study s308.3.003 in early pd patients

Conditions: Early Stage Parkinson's Disease

Summary: this is a multicenter, 6 months open label safety extension study for all patients who are willing and eligible to continue from the pivotal, double-blind s308.3.003 trial


Eligibility criteria:
inclusion criteria: * patients who have completed s308.3.003 trial exclusion criteria: * patients with medically relevant abnormal findings (ecg, physical examination, aes) at end of the maintenance phase (visit m6, week 24) of study s308.3.003

Keywords: parkinson's disease
impact of tadalafil 5 mg on post-micturition dribble in young-age men with no/mild lower urinary tract symptoms

Conditions: Lower Urinary Tract Symptoms

Summary: the primary objective of this prospective, single-centre randomized controlled trial is to assess the efficacy of tadalafil 5 mg on post-micturition dribble (pmd) in young age men (18-50 years) with no/mild lower urinary tract symptoms (luts).

post-micturition dribble (pmd), a post-voiding symptom, is defined as involuntary loss of urine immediately after urination. it is more common in males. many population/practice-based studies have shown that pmd is one of the most common bothersome urinary symptoms in adult males ranging from 5.5 % to 29 %. (1, 2) in young age men (less than 50 years) with absence of prostate-associated lower urinary tract symptoms (luts), pmd is considered the most devastating urinary complaint with worsened physical and mental health-related quality of life (hrqol). (3) pathophysiology of pmd is usually attributed to residual urine in the bulbar urethra whatever the cause. many theories, including weakness or failure of the pelvic floor muscles, incompetency of the external urethral sphincter or bladder neck obstruction, were suggested for this urine residue. (4) however, in patients with pmd with no/mild luts, pelvic floor muscle weakness especially the bulbocavernosus and ischiocavernosus muscles is usually the main putative mechanism. (5) bulbar urethral massage and pelvic floor muscle exercise have been proposed as useful options for patients with pmd (6); yet, pharmacological treatment has not been standardized for those patients. in this perspective, recent studies have shown that corpus cavernosum structural changes may be related to pmd. (7) it is well known that phosphodiesterase-5 (pde-5) isoenzymes are highly expressed in the urethra as well as the corpus cavernosum, bladder and prostate. (8) in addition, once-daily 5 mg tadalafil, a pde-5 inhibitor, has previously been used to treat voiding and storage luts. in addition, tadalafil once daily showed reduced pmd symptom severity and pmd volume in men with pmd and other luts. (9) notably, this study included old age men (mean age 62 years) with moderate or severe luts. the aim of the present study was to compare the effects of taking tadalafil 5 mg once daily on pmd in young men (18-50 years) with minimal/mild luts.

Eligibility criteria:
inclusion criteria: * 1- adult patients (aged 19-50 years) 2- complaining from pmd with no or mild luts (ipss\<8). exclusion criteria: * 1- patients with penile or urethral malformations 2- patients recently received pde5is in the last 4 weeks prior to study start. 3- systemic illness 4- contraindications to pde5is. 5- history of pelvic surgery or irradiation 6- history of bladder or prostate surgery 7- other acute medical conditions as acute gastroenteritis, osetoarthritis that might influence the patient qol

Keywords: post-micturition dribble lower urinary tract symptoms tadalafil quality of life
posterior capsule opacification and optical quality of different hydrophobic acrylic intraocular lenses

Conditions: Posterior Capsule Opacification

Summary: the most frequent long-term complication of cataract surgery remains to be posterior capsule opacification (pco). during the past decades many new intraocular lenses (iol) with optimized lens material and design were introduced. we propose a study comparing three acrylic single-piece iols with different design and hydrophobic material. all iols (hoya ny-60, hoya surgical optics gmbh; eyecee one, nidek co., aichi, japan) are commercially available and are used for routine cataract surgery. in this study a comparison of pco score of all two iols, a comparison of optic quality with wavefront analyses, visual acuity, contrast sensitivity, iol decentration and tilt, slitlamp examination, fibrosis, glistening intensity (subjectively scored), yag capsulotomy rate, and safety parameters (iol related adverse reactions) of the investigated iols will be performed. since pco develops slowly within years, a long-term follow-up of three years will be necessary. as those iols are currently often implanted iols, their performance on pco development and their optical quality is of high interest for the ophthalmologic community.


Eligibility criteria:
inclusion criteria: * bilateral age-related cataract for which phacoemulsification extraction and posterior iol implantation has planned * age 40 and older * visual potential in both eyes of 20/30 or better as determined by investigators estimation * normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant exclusion criteria: * preceding ocular surgery or trauma * relevant other ophthalmic diseases (such as pseudoexfoliation, retinal degenerations, etc.) * uncontrolled systemic or ocular disease
improving diabetes care:effectiveness of physician profiling and care coordination by a diabetes resource nurse

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to test the effectiveness of physician profiling and care coordination by a diabetes resource nurse in improving the quality of diabetes care.

healthtexas provider network primary care practices with at least 10 medicare diabetes patients over the age of 65 were randomized to one of 3 intervention arms: physician feedback of process measures using medicare claims data ("claims"); feedback of medicare claims data plus clinical measures from medical record abstraction ("claims+mr"); or both types of feedback plus a practice-based drn ("drn"). for the 12 months prior to the intervention and 12 months post-intervention, performance data on diabetes related processes of care (annual hba1c testing, annual ldl cholesterol screening, annual hypertension screening, annual eye, foot, and renal assessment) and patient outcomes (hba1c level, ldl cholesterol level, blood pressure) were collected from medical record abstraction and medicare claims data. pre-post change scores will be compared between intervention arms to examine effectiveness of physician profiling and care coordination by a diabetes resource nurse.

Eligibility criteria:
inclusion criteria: * age ≥ 65 years on january 1, 2000 * diagnosis of diabetes mellitus * diabetes related visit to htpn physician within the past year * resident of texas * medicare insurance coverage exclusion criteria: * patient chart not available for abstraction

Keywords: diabetes care coordination case management physician profiling
pancreaticogastrostomy for high-risk pancreas

Conditions: Anastomosis; Complications; Pancreatic Fistula

Summary: in 2013, a double purse-string telescoped pancreaticogastrostomy (pg) technique appeared to significantly reduce the risk of postoperative pancreatic fistula (popf). this study compared the incidence of clinically relevant popf in patients with high-risk anastomosis after undergoing pg or pancreaticojejunostomy (pj) techniques.

from 2013 to 2019, consecutive patients with high-risk anastomosis (i.e., updated alternative-fistula risk score (ua-frs) \>20%) underwent pancreatoduodenectomy with either the pj or pg technique. optimal mitigation strategy (external stenting and octreotide omission) was applied for all patients. the primary endpoint of the study was the incidence of clinically relevant popf. data were entered prospectively into an institutional clinical database (nct02871336).

Eligibility criteria:
inclusion criteria: * pancreatoduodenectomy * high updated alternative -fistula risk score which was defined \> 20%, as the higher-risk category of the alternative-fistula risk score exclusion criteria: * explorative laparotomy * hard pancreatic parenchyma

Keywords: high risk pancreatic anastomosis clinically relevant pancreatic fistula pancreaticogastrostomy
long-term survival after single-ventricle palliation

Conditions: Heart Defects, Congenital

Summary: a nationwide observational study. children operated with single-ventricle palliation between january 1994 and december 2017 operated in sweden will be included retrospectively. patients born with a functionally single ventricle but not undergoing surgery will not be included. data regarding preoperative clinical characteristics and operative details will be obtained by medical records review and from the swedish registry of congenital heart disease (swedcon). using unique personal identity numbers assigned to all residents of sweden, data from swedcon will be linked with dates of death.


Eligibility criteria:
inclusion criteria: * operated with single-ventricle palliation between january 1994 and may 2017 in sweden. exclusion criteria: * none.
evaluation and comparison of 2 cosmetic investigational products in adults with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the study consists in the application of 2 investigational products (one group per investigational product) under normal conditions of use, in adult participants with atopic dermatitis. it is carried out on cosmetic products, with the aim to further confirm safety of these products

probiotics are live micro-organisms which when administered in adequate amounts can exert a health benefit on the host. this health-promoting effects of lactobacillus reuteri have been extensively studied in the gastrointestinal tract but it is clear that other areas are also interesting for the use of probiotics. atopic dermatitis is a relapsing inflammatory skin disease appearing on persons with a genetic predisposition of allergic pathology. ad generally starts in childhood, however in some cases can continue into adult hood, in at least 10% of cases. ad can effect a persons quality of life and in the chronic stage it can present with dry skin and lichenification. research has shown that probiotics have an antimicrobial, anti-inflammatory and barrier function effect, and could therefore be used on subjects with atopic dermatitis to relieve and protect.

Eligibility criteria:
inclusion criteria: * participant has not been on a course of long term treatment in particular with aspirin, products containing aspirin, anti-inflammatories, antibiotics, antihistamines, corticoids * participant presenting with mild to moderate atopic dermatitis according to the definition of the uk working party's diagnostic criteria for atopic dermatitis (scorad index \>25) * participant presenting with a current lesion of atopic dermatitis on defined area exclusion criteria: * participant is pregnant, breast feeding or not willing to take the necessary precautions to avoid pregnancy during the study * participant having background of intolerance or allergy * participant not respecting the washout period during which a person may not be involved in any other biomedical research projects * participant having skin exposed to sunlight within 2 weeks preceding the inclusion * participant having modified his/her cosmetic habits during the last two weeks

Keywords: probiotic atopic dermatitis lactobacillus reuteri
impact of the implementation of dance therapy workshops on the quality of life of dependent elderly people institutionalized within the establishments of the univi group

Conditions: Dance Therapy Workshop

Summary: dance is a multimodal activity involving motor, cognitive, sensory and sensory-motor skills as well as emotional and social skills. a growing body of research shows that the creative arts and physical exercise are able to alleviate disability, improve social interactions, and slow the progression of alzheimer's disease and related disorders. the associative group univi wants to evaluate through this study the effects of the practice of dance on the quality of life of the people accommodated in its usld and ehpad

this research is an interventional study involving the human person of category 2 involving only minimal risks and constraints, it is multicentric and longitudinal prospective. this is a before/after study to measure the effects of the implementation of a dance therapy activity on the quality of life of the elderly population housed in the 30 establishments of the univi group. the dance therapy will be deployed in all the medico-social establishments participating in the study over a period of 12 weeks. to do this, dance therapists will be recruited to provide these classes. the dance-therapy will be carried out: * in groups of 10 to 12 people who have given their informed consent, * at least twice a week per group, * over a period of 30 to 45 minutes maximum twice a week for 3 months. several groups per establishment can be planned depending on the number of people who can and want to be included in the dance workshop. 940 participant in the study will be inclued and followed at 1 month, 3 months and 6 months after the end of the dance therapy workshops.

Eligibility criteria:
inclusion criteria: * people aged over 60 * dependent elderly people residing in ehpad or usld including people under guardianship and curatorship * people having signed an informated and weitten consent * people with a minimum of language skills to understand instructions and simple questions exclusion criteria: * participants in palliative care * contraindication to the practice of dance * severe cognitive and/or behavioral disorders that do not allow you to follow a dance workshop * permanent bed rest * non-affiliation to a social security scheme
comparability of hemodynamic parameters measured by non-invasive echocardiography and by right heart catheterization

Conditions: Heart Failure

Summary: this study is to compare transthoracic echocardiography tte to the gold standard right heart catheterization in terms of accuracy to measure hemodynamic parameters.

chronic heart failure is a progressive disease in western population. echocardiography and right heart catheterization are important tools in the diagnosis and progress monitoring of heart failure. gold standard in diagnosis of hemodynamic parameters in patients with heart failure is right heart catheterization. however, this diagnostic device represents an invasive method that is additionally associated with high risks such as infections, vessel and nerve injuries. echocardiography is probably in a position to determine hemodynamic parameters as reliably as right heart catheterization without additional health risk due to its non-invasive character. all procedures performed are part of clinical routine. patients do not undergo any study-specific procedure at all.

Eligibility criteria:
inclusion criteria: * chronic heart failure nyha i - iv exclusion criteria: -

Keywords: echocardiography right heart catheterization