Kornimate/medical-research-clean huggingface dataset:
impact of front-of-package labels on weight bias among latines

Conditions: Weight Prejudice

Summary: the goal of this experiment is to examine the effects on explicit weight bias of a selection task using 4 different types of front-of-package food labels to select healthy or unhealthy foods among a sample of latine and low english proficiency adults. the main questions this experiment aims to answer are: * does the use of different front-of-package label designs in a selection task lead to different effects on explicit weight bias among latine and low english proficiency consumers? * does the use of different front-of-package label designs in a selection task lead to different effects on attribution of personal responsibility for body weight among latine and low english proficiency consumers? participants will be randomly assigned to 1 of 4 types of front-of-package label designs. they will view 3 sets of products (frozen meals, frozen pizzas, and frozen desserts), shown in random order. for each product set, participants will view 3 products shown in random arrangement, each with participants' randomly assigned label shown on the front of package. after viewing all 3 product types, participants will answer questions about explicit weight bias and attribution of responsibility for body weight. researchers will compare results across label designs.

this study aims to determine if the use of different front-of-package label types in a selection task leads to different effects on explicit weight bias and attribution of responsibility for body weight among latine and low english proficiency (lep) consumers. a latine-focused panel company will recruit 4,000 us latine adults of parental age (18-55 years), approximately 50% of whom will have low english proficiency (lep). in a between-subjects experiment, researchers will randomize participants to 1 of 4 types of front-of-package labels: a numerical label, an interpretive text-only label, an interpretive label with a magnifying glass icon, or separated interpretive labels with a magnifying glass icon. participants will first perform a selection task for a parent study in which they will view their assigned label on 3 sets of products (with 3 products per set) and select the product they believe is most and least healthy and the product they most want to purchase. after this selection task, participants will answer questions measuring this study's outcomes: explicit weight bias (primary outcome) and attribution of personal responsibility of body weight (secondary outcome).

Eligibility criteria:
inclusion criteria: * identifying as latine or hispanic * ages 18-55 years old * residing in the united states exclusion criteria: * not identifying as latine or hispanic * less than 18 or greater than 55 years old * not residing in the united states
the impact of a musical starry sky projector on fatigue, sleep, and quality of life in pediatric oncology patients

Conditions: Pediatric Oncology; Sleep Problems; Fatigue Intensity; Quality of Life

Summary: this study evaluated the effect of an ocean wave and led starry sky projector on fatigue, sleep, and quality of life in pediatric oncology patients.

sleep disturbances and fatigue were common issues among pediatric oncology patients, significantly impacting their overall quality of life. this study aimed to evaluate the effect of an ocean wave and led starry sky projector on fatigue, sleep patterns, and quality of life in this patient population. the research was structured as a parallel-group, randomized controlled trial. pediatric oncology patients, aged 8-18 years, were recruited for participation. the study intervention group used the ocean wave and led starry sky projector each night for one month, along with receiving the standard care typically provided in the oncology unit. the projector created a soothing visual and auditory environment designed to help induce relaxation, potentially improving sleep and reducing fatigue. meanwhile, the control group received only the standard care offered to pediatric oncology patients, without the addition of the projector intervention. this study offered valuable insights into the use of non-pharmacological interventions for improving sleep quality and reducing fatigue among pediatric oncology patients.

Eligibility criteria:
inclusion criteria: * pediatric oncology patients aged 8-18 years. * recently diagnosed (\&lt; 1 month). * active receiving chemotherapy treatment * able to read and write in turkish. * willing to participate voluntarily. exclusion criteria: * being at the end of life * diagnosed with mental problems. * haemoglobin levels below 7 mg/dl). * having visual or hearing impairments. * unable to understand or communicate in turkish.

Keywords: fatigue, pediatric oncology, sleep, quality of life
factors and prognosis of obstructive pyelonephritis patients

Conditions: Pyelonephritis; Prognostic

Summary: acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit. most of the available data on this condition comes from small, retrospective, single-centre series. to date, no large-scale study has examined the factors associated with the prognosis of patients admitted to intensive care for acute obstructive pyelonephritis. the aim of this study is to describe the population and prognosis of patients admitted to the intensive care unit for the management of acute obstructive pyelonephritis, and to identify factors associated with a poor prognosis in these patients.

the retrospective and multicenter study consists of a retrospective and pseudonymous collection of data from medical reports of patients treated, over the period 2015-2022, in each intensive care unit agreeing to participate, . investigators from each participating center will be responsible for screening on all hospitalized patients over the period 2015-2022. patients who have been hospitalized for the management of acute obstructive pyelonephritis will be included, in the absence of non-inclusion criteria.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * hospitalized in intensive care for management of acute obstructive pyelonephritis * patients affiliated to a social security system exclusion criteria: * pregnancy * opposition to data use * persons under legal protection (curatorship, guardianship), legal safeguards

Keywords: acute kidney injury renal remplacement therapy hemodialysis acute respiratory distress hemodynamic failure
safety and efficacy of thn102 on sleepiness in narcoleptic patients

Conditions: Narcolepsy

Summary: this phase 2 study is a 8-site, double-blind, randomised, placebo-controlled, 3-way cross-over trial, involving 3 treatments with modafinil 300 mg or the combination drug thn102 (modafinil/flecainide 300 /3 mg, modafinil/flecainide 300 /27 mg).

the 3 double blind periods (2-week) follow a stabilisation period for modafinil at 300 mg/day (open, 2-week) and are followed by a one-week washout period with the same modafinil dose.

Eligibility criteria:
main inclusion criteria: * patients with a diagnosis of narcolepsy type 1 (i.e. with cataplexy) or type 2 (without cataplexy) according to the international classification of sleep disorders (icsd-3) criteria. * body mass index \>18 kg/m2 and \<35 kg/m2. * patients treated with modafinil at stable dosage for at least 2 months and still complaining of excessive daily somnolence (eds) despite the treatment * epworth sleepiness scale (ess) score should be ≥ 14/24 during the baseline period. main exclusion criteria: * patients with an untreated sleep apnea syndrome (respiratory disorder index \> 30/h) or who have any other cause of daytime sleepiness as assessed on patient history. * psychiatric and neurological disorders, other than narcolepsy/cataplexy, such as parkinson's disease, alzheimer's disease, huntington's chorea, multiple sclerosis, moderate or severe psychosis or dementia, bipolar illness, epilepsy, severe clinical anxiety or depression, beck depression inventory ≥ 21 or with suicidal risk (if item \> 0), or other problem that in the investigator's opinion would preclude the patient's participation and completion of this trial or comprise reliable representation of subjective symptoms. * contraindication to flecainide
phase 2b study of gc4711 in combination with sbrt for nonmetastatic pancreatic cancer

Conditions: SBRT; Borderline Resectable Pancreatic Cancer; Unresectable Pancreatic Cancer

Summary: gti-4711-201 is designed as a phase 2b, multicenter, randomized, double-blind, placebo-controlled study to determine the effect to os by adding gc4711 to sbrt following chemotherapy in patients with unresectable or borderline resectable nonmetastatic


Eligibility criteria:
inclusion criteria: 1. histological or biopsy proven adenocarcinoma of the pancreas. cytology is acceptable if histology cannot be obtained. 2. newly diagnosed non-metastatic pc judged by tumor board to be feasible for sbrt 3. completed at least 6 weeks of chemotherapy consisting of folfirinox, mfolfirinox, or a gemcitabine-based doublet regimen prior to start of sbrt 4. remain non-metastatic as confirmed by a ct scan at screening. 5. female or male subjects ≥ 18 years of age 6. ecog performance status of 0-2 7. adequate end-organ function exclusion criteria: 1. subjects with documented metastatic disease 2. first-line chemotherapy other than folfirinox, mfolfirinox, and/or a gemcitabine-based doublet regimen 3. prior abdominal rt with substantial overlap in radiation fields 4. subjects not recovered/controlled from treatment-related toxicities 5. uncontrolled malignancy other than pc 6. uncontrolled gastric or duodenal ulcer disease within 30 days of dosing 7. visible invasion of bulky tumor into the lumen of the bowel or stomach on endoscopy
can brief exposure to hyperoxia improve function after chronic spinal cord injury?

Conditions: Spinal Cord Injuries

Summary: this proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic, severe spinal cord injury (sci).

this proof-of-principle study will include a small number of participants with subacute or chronic (\>3 months post-injury), severe spinal cord injury (i.e., ais a, b or c). after screening for potential contraindications, participants will attend 4 experimental sessions. in each session, their sensory or reflex function will be tested at regular intervals. once baseline recordings are established, participants will be given either room air or 99% oxygen to breathe through a face mask for 2 minutes. it will be determined if breathing 99% oxygen results in a change in the sensory and motor functions recorded before and shortly after breathing oxygen. administration of a high concentration of oxygen at atmospheric pressure for a short duration has been completed without adverse effects in healthy individuals, and individuals with various forms of injury including chronic obstructive lung disease, traumatic brain injury, stroke, and spinal cord injury. duration of administration has ranged from 3 min to 4 hours without adverse effects. if this initial trial indicates that improvements in sensory and motor function are induced by this short exposure, exploration of therapeutic ways to increase blood flow to the spinal cord will be undertaken

Eligibility criteria:
inclusion criteria: 1. individuals with traumatic sci with onset ≥3 months prior, 2. between 18 - 65 yr old, 3. asia impairment scale at discharge classified as a, b or c, 4. injury level between c5 and t10, 5. able to give informed, written consent. exclusion criteria: 1. frequent uncontrolled autonomic dysreflexia, 2. uncontrolled high blood pressure, 3. cardiac or cardiovascular disease, 4. cancer, 5. active urinary tract infection, 6. active pressure sores, 7. signs of deep vein thrombosis in the legs, 8. severe swelling of the feet and/or legs, 9. severe cognitive impairment, 10. pulmonary dysfunction such as chronic obstructive pulmonary disease or acute respiratory infection, 11. any condition which would be exacerbated by sitting or lying in one position for 2 hours, such as low back pain 12. pregnancy.

Keywords: hypoxia hyperoxia reflex sensation
a large randomized trial of vitamin d, omega-3 fatty acids and cognitive decline

Conditions: Cognitive Decline

Summary: the vitamin d and omega-3 trial (vital; nct 01169259) is an ongoing randomized clinical trial in 25,875 u.s. men and women investigating whether taking daily dietary supplements of vitamin d3 (2000 iu) or omega-3 fatty acids (omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. this ancillary study is being conducted among participants in vital and will examine whether vitamin d or fish oil is associated with cognitive decline in 3000 older participants of vital.

primary aim of annual rate of cognitive decline. secondary aims will be addressed in sub-set of participants: 1) among participants, african-american race (african-americans have high risk of vitamin d deficiency) modifies effects of vitamin d3 supplementation on cognitive decline; 2) among a subset of participants, baseline plasma levels of vitamin d and omega-3 fatty acids modify agent effects.

Eligibility criteria:
participants in vital (nct 01169259) who meet the following criteria are eligible to participate in this ancillary study: 1. are aged 60 or more 2. have no hearing impairment 3. indicate a willingness on the run-in phase to participate in a cognitive sub-study.
an ankle-foot orthosis improves gait performance and satisfaction in stroke patients

Conditions: Gait Analysis

Summary: all participants were at least 6-month post-stroke and had unilateral limb involvement (8 right/4 left). the main inclusion criteria in selection of the participants in this study were as follows :(1) first stroke (2) at least 6 months post stroke (3) able to stand for at least one minute without any assistive devices (4) able to walk for at least 10 meters. all participants were instructed to walk with bare foot or with ankle-foot orthoses(afos) separately under gait detection of the motion capture system. participants were further instructed to complete the 10 meter walk test at a comfortable speed with bf or with afos separately. all participants were provided with sufficient rest between each trial. patient demographics such as lower limb brunnstrom stage and modified ashworth scale (mas) score were examined and recorded by experienced therapist. the satisfaction and outcome were measured by the quebec user evaluation of satisfaction with assistive technology (quest) and sf-36. the kinematic and kinetic data were collected by motion analysis system.


Eligibility criteria:
inclusion criteria: * first stroke * at least 6 months post-stroke * able to stand for at least one minute without any assistive devices * able to walk for at least 10 meters. exclusion criteria: * unable to walk for at least 10 meters.

Keywords: 3d printed technology ankle-foot orthosis (afo) stroke gait parameters gait analysis kinetics kinematics
hiv prevention among at-risk latinos in the heartland

Conditions: HIV Infections

Summary: this study is a randomized controlled trial that evaluates the efficacy of a network intervention to promote regular hiv testing and prevention (risk reduction and prep awareness and referrals) among friendship networks of latino men who have sex with men and transwomen (lmsmt) in three mid sized midwestern cities.

to benefit from early hiv diagnosis, the cdc suggests that groups at higher hiv risk get tested regularly. the study will evaluate the efficacy of an intervention to promote regular hiv testing and prevention (risk reduction and prep awareness and referrals) among friendship networks of latino men who have sex with men and transwomen (lmsmt) in three midsized midwestern cities. the intervention uses the relationships that permeate networks of lmsmt by training well-positioned members to encourage a collective response to the epidemic and to disseminate hiv testing and prevention messages and resources within the network. thus, we will (a) recruit 36 friendship networks of lmsmt in milwaukee, cleveland, and indianapolis (n ≈ 432); (b) test them for hiv and recommend that they test regularly; (c) invite key members of 18 randomly selected networks to a 4-session training to promote regular hiv testing and prevention in their networks; (d) conduct chart reviews to verify regular testing and prep visits and assess regular testing, prep visits, and risk behavior and mediators at 6, 12 and 18-month follow up.

Eligibility criteria:
inclusion criteria: * latinx men who have sex with men or transgender women 18 or more years of age. * lives in the milwaukee, cleveland or indianapolis area. * can provide informed consent. * additional inclusion criteria for networks: 80% or more of the network is of latinx descent. exclusion criteria: * cis-gender female. * did not have sex with men or identify as homosexual or bisexual. * cannot provide consent.

Keywords: hiv latinos networks men who have sex with men transgender usa midwest
effect of an educational intervention on cpr knowledge and skills in schoolchildren

Conditions: CPR; Cardiac Arrest (CA)

Summary: this study aims to evaluate the effectiveness of a cpr intervention for children aged 7 and 8. given the high prevalence of out-of-hospital cardiac arrests (ohca) and the proven benefits of early cpr training, the study seeks to determine whether a structured intervention can improve young children's knowledge and skills in basic life support. what is the effect of a cpr training intervention on the knowledge and skills of 7- and 8-year-old schoolchildren? cardiac arrest is a leading cause of mortality worldwide. research shows that survival rates increase significantly when cpr is performed promptly by a trained bystander. countries with early cpr training programs in schools, such as norway and denmark, report better survival outcomes. however, in latin america, cpr education in schools is still in its early stages. evidence suggests that children can effectively learn and retain cpr knowledge, and they can serve as multipliers by passing their knowledge to family and peers. study design: this is a non-randomized, double-blind controlled trial with four phases:

intervention design - developing an age-appropriate cpr training intervention based on educational and cognitive development theories. content validation - experts in child education and health professionals will assess the content and delivery methods. validation of assessment tools - ensuring reliability in measuring children's cpr knowledge and skills. intervention implementation and evaluation - the intervention will be conducted in schools, with pre- and post-tests assessing knowledge and skills retention after 3 months. expected outcomes: improved knowledge and skill levels in cpr among children who receive the intervention. validation of a structured educational approach for teaching cpr to young children. contribution to global evidence on cpr education and its potential impact in bogotá schools.

Eligibility criteria:
inclusion criteria: * schoolchildren aged between 7 and 8 years. * students enrolled in an educational institution that has authorized their participation in the study. * not participating in any other intervention or educational program related to cpr during the study period. exclusion criteria: * students whose parents, legal guardians, teachers, or the students themselves report any health condition that prevents them from participating in the study. * students who indicate having received prior training in cpr or related skills. * students whose parents, legal guardians, or teachers report any cognitive condition that limits their ability to understand and follow the instructions necessary to learn and practice cpr in simulated scenarios.

Keywords: schoolchildren learning intervention knowledge skills
trial of fresh start weight loss intervention in wic participants

Conditions: Obesity

Summary: the fresh start postpartum weight loss program will test the effectiveness of a group-based weight loss intervention that includes videos featuring peers who have successfully achieved postpartum weight loss. the group-based condition will be compared to a control condition involving print materials related to weight loss.

the goal is to study the effectiveness and implementation of a postpartum weight loss intervention for wic clients that has potential for sustainability. the investigators will compare outcomes among participants in a group-based weight loss intervention condition (fresh start) to outcomes among participants in a self-directed, print materials only, comparison group. the fresh start intervention, informed by formative research studies, consists of an 8-session group-based weight loss intervention delivered by wic nutritionists and peer leaders. the intervention integrates key educational and skill building strategies from the lifestyle arm of the diabetes prevention program with delivery strategies and messages specific for the wic program and postpartum women. the intervention will be evaluated in a randomized clinical trial that will contribute to generalizable knowledge.

Eligibility criteria:
inclusion criteria: * 6 months or less postpartum * speaks english * bmi 25 or greater * client of wic program, worcester ma exclusion criteria: * not able to give informed consent