Kornimate/medical-research-clean huggingface dataset:
global congestive heart failure registry

Conditions: Heart Failure

Summary: heart failure (hf) is a major health problem worldwide but there is no global hf study that documents demographics, socioeconomic and clinical factors, diagnostic and management patterns, etiology, biomarkers, co-morbidities, treatments, quality of life, barriers to care and outcomes in all parts of the world. such knowledge is essential in the prevention and treatment of this global disease. the global congestive heart failure registry (g-chf) is a global registry of approximately 20,000-25,000 hf patients enrolled over approximately 5 years to study these risks and causes of hf.

the g-chf registry is a prospective global cohort study of approximately 20,000-25,000 hf patients enrolled over approximately 5 years. baseline data will be obtained on demographic and socioeconomic data, clinical and laboratory variables, co-morbidities, biomarkers, echocardiography, hf causes, medication use, management patterns, quality of life, and health systems. six-month, 12-month, 18-month and 24-month follow-up data will be obtained to document patient outcomes and factors associated with outcomes. a sub-study of approximately 4000 patients (a subset of the main study population) will be performed to measure frailty, cognitive and lung function, mental health, medication adherence, patient-reported barriers to care, dietary assessment, and collection of blood and urine samples for central storage and analysis.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age with a clinical diagnosis of hf seen in outpatient clinics or inpatient hospital wards of the participating centres. * written informed consent exclusion criteria: * patients considered unreliable by the investigator concerning the requirements for follow-up visits.

Keywords: cardiac failure congestive heart failure heart decompensation heart failure, congestive heart failure, left-sided heart failure, right-sided left-sided heart failure myocardial failure right-sided heart failure outcomes co-morbidities biomarkers
modulation of vascular calcification in chronic dialysis patients

Conditions: Vascular Calcification

Summary: 50 patients will be randomized and treated with mco or highflux dialysis for six months (24 weeks) after a run-in phase of 4 weeks highflux treatment. serum samples will be drawn at baseline, after 4, 8 and 24 weeks. later, calcifiying vascular smooth muscle cells will be incubated with these serum samples and calcification will be assessed with alkaline phosphatase and alizarin staining. primary endpoint: in vitro calcification of coronary vascular smooth muscle cells (alkaline phosphatase/ wst8) after six months calcifiying vascular smooth muscle cells will be incubated with serum samples obtained after six months of mco/hf dialysis and calcification will be assessed with alkaline phosphatase and wst8. secondary endpoints: aortic pulse wave velocity after 6 months calcification propensity after 6 months physical activity level after 6 months cell culture: incubation of vsmc with serum samples obtained after 6 months * alizarin staining/wst-8 * measurement of calcification inhibitors osteopontin and matrix gla protein in supernatants * apoptosis the treatment regimen of the patients will not be altered, hence blood flow, dialysate flow as well as dialysis time will remain constant.


Eligibility criteria:
inclusion criteria: * age 18 years an older * chronic dialysis patients for at least 3 months exclusion criteria: * serum albumin \<32g/l at the last routine albumin measurement * pregnancy
hidradenitis suppurativa prospective observational registry and biospecimen repository

Conditions: Hidradenitis Suppurativa

Summary: hidradenitis suppurativa (hs) is a common and debilitating skin disease that is poorly understood and understudied. as a result, little is known about disease prognosis and few effective treatments exist for this condition. this prospective observational cohort study aims to comprehensively characterize the clinical and biological features of hs. the results of this research will provide a basis for the development of an hs clinical classification system and identification of potential treatments for hs.


Eligibility criteria:
inclusion criteria: 1. male or female ≥ 10 years of age 2. diagnosis of hs by a dermatologist or practitioner experienced in making a diagnosis of hs 3. written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study. exclusion criteria: 1. inability to give informed consent or unavailability of a parent/guardian who is able and willing to give informed consent.
patterns and outcomes of neurosurgery in england over a five-year period

Conditions: Surgery; Surgery--Complications; Neurological Morbidity; Neurological Diseases or Conditions; Neurological Disorder; Neurological Complication; Neurological Procedural Complication; Outcome, Fatal; Comorbidities and Coexisting Conditions; Morality

Summary: neurosurgical practice has seen many important changes over several decades with advances in treatments and the types of patients treated. neurosurgical procedures have evolved, and as outcomes have improved the number of patients being treated has increased. there are no recent evaluations of national neurosurgical practice in the united kingdom (uk), with the last prospective cohort studies being safe neurosurgery 1993 and safe neurosurgery 2000. more recent studies of neurosurgical services have been based on data from single institutions or surgeons and these may not give a representative picture of practice nationally. recent national quality improvement programmes for neurosurgery in england (such as the national neurosurgical audit programme (nnap) and cranial neurosurgery and spinal surgery getting it right first time (girft) programmes) have focused on using national hospital administrative datasets. to be effective, quality improvement initiatives require robust outcome measures and quality (process) indicators. currently, there is a lack of validated quality indicators for neurosurgery, with practice often being described using generic measures such as readmission and reoperation rates and length of stay. many studies have been able to derive these common outcome measures, but it may also be possible to produce indicators specific to neurosurgery. the aim of this observational study was firstly to describe the current pattern of neurosurgical admissions and procedures in england, and thereby given an overview of the epidemiology of neurosurgical patients. secondly, it aims to investigate the range of outcome measures that might be produced from hospital administrative data and use these to assess the quality of care in neurosurgery.


Eligibility criteria:
inclusion criteria: * all admissions to neurosurgical units in the national health service (nhs) in england. exclusion criteria: * records with poor quality data (e.g. no data for clinical diagnoses). * patients under 18 years that were admitted to an adult neurosurgical unit.
generalized hypersensitivity in patients with fibromyalgia syndrome

Conditions: Fibromyalgia

Summary: fibromyalgia (fm) is a chronic musculoskeletal pain disorder with unknown causes. our previous studies showed abnormal sensations of second pain (wind-up), indicating central hypersensitivity as an important mechanism of fm. triggering events have been implicated as the cause of central hypersensitivity.

increasing evidence has shown that the hypersensitivity of fm is not limited to painful stimuli but seems to extend to non-painful stimuli as well. these stimuli include smell, taste, touch, light, and sound. this study will provide detailed qst examinations of fm subjects and controls' responses to light using visually evoked potentials (vep). in addition, careful characterization of experimental pain responding across multiple sensory modalities will be examined.

Eligibility criteria:
inclusion criteria: * individuals diagnosed with fm will have pain of \> 3 months and meet the 1990 and 2011 diagnostic criteria for fm (acr) * healthy, pain-free age and sex matched controls without chronic pain exclusion criteria: * presence of chronic disease (e.g. cancer, cardiovascular disease, liver disease, kidney disease, diabetes, etc.). * fm patients must be willing to discontinue or hold their fm related medications for a minimum of one day prior to the visit. * significant vision loss not corrected by eye wear * family history of photosensitive epilepsy

Keywords: central sensitization peripheral sensitization visual evoke potentials (vep) quantitative sensory testing
improving hypertension control in east and central harlem

Conditions: Hypertension

Summary: this hypertension project is evaluating strategies developed to target problems underlying lack of blood pressure control among treated but uncontrolled hypertensive patients in east and central harlem.

the hypertension project will tailor improvement strategies to the problems identified as underlying underuse among treated but uncontrolled hypertensive patients in east and central harlem, new york city. along with the communities' 6 major health providers, we will first combine qualitative and quantitative methods to identify specific patient, provider, and system problems, and customize interventions to address them. in a randomized controlled trial, we will then randomly assign 480 patients among 4 arms: nurse management, blood pressure monitors alone, usual care, and peer led chronic disease self-management course. during the 18-month trial, patients self-monitor their blood pressure or attend a self-management course, or nurse managers will assess patients' needs, counsel them, address any access barriers, and follow up with regular telephone contacts; convey information, including blood pressures from patients' self-monitoring, between patients and physicians to inform possible medication changes; and ameliorate any systems problems. we will assess differences in blood pressure reductions among the 4 arms as the primary outcome, and in quality of life, patient satisfaction, costs, and cost-effectiveness as secondary outcomes. the findings will provide new knowledge about the relationship between these changes and patient and clinician knowledge, attitudes, and behaviors. the educational course is designed to teach patients tools for managing their chronic illness which will empower them to improve their overall health and is specifically tailored for patients living with asymptomatic chronic illnesses and will emphasize communication with health care providers. in partnership with community organizations and the policymakers, we will disseminate successful findings within these communities and throughout the state and the nation.

Eligibility criteria:
inclusion criteria: male and female, english or spanish speaking african american and/or hispanic patients with uncontrolled hypertension who have been seen in either the cardiology clinic, internal medicine associates (ima) or geriatric clinic at least twice in a given year at least 18 years of age. exclusion criteria: this study is about hypertension control among african americans and hispanics, these are the ethnic groups with disparities in cvd that we want to improve so other races are excluded. the study is for adults with hypertension; therefore, we are excluding anyone who is under 18 years of age.

Keywords: hypertension blood pressure self management nurse management racial disparities cardiovascular disease
effect of neoadjuvant chemoradiation on pathologic complete response rates in locally advanced breast cancer patients

Conditions: Breast Cancer Female

Summary: this is a phase ii randomized trial comparing pathologic complete response rates in locally advanced patients recieving either neoadjuvant chemotherapy or neoadjuvant chemoradiation.

a prospective randomized phase ii trial, that enrolled locally advanced breast cancer patients who were randomized to recieve either neoadjuvant systemic treatment or neoadjuvant systemic treatment concurrently with radiotherapy. surgery is done for all patients later on as indicated. the pathological response rates between both groups will be compared, as well as surgical complications and acute radiation toxicity.

Eligibility criteria:
inclusion criteria: 1. female patients. 2. age: 21 years or older. 3. ecog performance status (ps) score 0 to 2. 4. locally advanced tumors (stage iiia or above) of any subtype. 5. early breast cancer of the her2+ or tnbc subtype when: 1. node-negative, t2 or t3. 2. node-positive, any t stage. exclusion criteria: 1. patients initially presenting with metastatic breast cancer. 2. patients unfit to receive planned regimen of treatment that had a poor ps (i.e.: ps 3 and 4). 3. inflammatory breast cancer (t4d) patients. 4. patients having contraindications to radiotherapy (e.g.: pregnancy, history of previous chest wall, breast, or axillary irradiation) 5. history of previous ipsilateral breast surgery. 6. comorbidities that would affect skin healing or integrity, like uncontrolled diabetes mellitus or active autoimmune collagen or vascular diseases

Keywords: preoperative radiotherapy locally advanced breast cancer pathologic response
aerosolized vancomycin in methicillin-resistant staphylococcus aureus pneumonia under mechanical ventilation

Conditions: Pneumonia, Staphylococcal; Methicillin-Resistant Staphylococcus Aureus

Summary: the purpose of this study is to determine whether aerosolized vancomycin is effective in the treatment of methicillin-resistant staphylococcus aureus pneumonia under mechanical ventilation.


Eligibility criteria:
inclusion criteria: * nosocomial or severe community-acquired pneumonia due to methicillin-resistant staphylococcus aureus * must be mechanically ventilated in intensive care unit exclusion criteria: * non-bacterial pneumonia, such as viral, fungal, tuberculosis infections * underlying respiratory condition: bronchiectasis, post-tuberculosis, chronic obstructive pulmonary disease or asthma * complicated pneumonia, such as empyema, parapneumonic effusion requiring chest tube or drainage * already or previous treated with intravenous vancomycin (not pneumonia) * adverse reaction due to inhaled ventolin before treatment of aerosolized vancomycin * hypersensitivity of vancomycin or glycopeptide antibiotics * positive culture of enterococcus in respiratory specimen * pregnant or breast-feeding patient * immunocompromised hosts: more than 1mg/kg of corticosteroid users for more than 3 months, transplantation recipients, aids patients * another aerosolized antibiotics within 48 hours of study enrollment * not adherent to mechanical ventilation protocol of this study * not arterial line monitoring * vancomycin minimum inhibitory concentration \>= 2㎍/㎖ of cultured staphylococcus aureus
multi-centre study to compare efficacy and safety of afolia and gonal-f in women for assisted reproductive treatment

Conditions: Infertility

Summary: ther purpose of this study is to show equivalence between afolia and gonal-f® with regard to the number of oocytes retrieved in women for assisted reproductive treatment.


Eligibility criteria:
inclusion criteria: * age between 20 and 38 years with regular menstrual cycles of 25-35 days * first or second cycle in the present series of art * bmi ≥ 18 ≤ 30 kg/m2 * basal fsh \< 10 iu/l (cycle day 2-5) * e2 levels \< 50pg/ml (\< 0.18 nmol/l) at the day of fsh administration * antral follicle count (afc) ≥ 10 to ≤ 25 follicles (sum of both ovaries) * infertility due to any of the following factors: tubal factor, mild endometriosis (asrm stage 1-2), male factor, unexplained infertility * presence of both ovaries and normal uterine cavity (confirmed by transvaginal ultrasound within 6 months before randomisation) * willingness to participate in the study and to comply with the study protocol * informed consent exclusion criteria: * presence of pregnancy * history of ≥2 succeeding art cycles (ivf and/or icsi) before the study cycle without clinical pregnancy * presence of clinically significant systemic disease * presence of chronic cardiovascular, hepatic, renal or pulmonary disease * presence of uncontrolled endocrine disorder * previous history or presence of severe ovarian hyperstimulation syndrome * presence of polycystic ovaries (pco) * presence of severe endometriosis (asrm stage 3 or stage 4) and hydrosalpinx * neoplasia, including tumors of the hypothalamus and pituitary gland * abnormal bleeding of undetermined origin * history of poor response to gonadotropin treatment (defined as fewer than 5 oocytes retrieved in a previous attempt) * male infertility without mobile spermatozoa in the ejaculate, that need testicular of epididymal sperm retrieval (mesa/tese/tesa) * endocrine abnormality such as tsh or prolactin level elevations outside the reference range if clinically relevant at screening * any hormonal treatment within 1 month before the start of the fsh treatment (with the exception of levothyroxin) * history of drug, nicotine or alcohol abuse within the last 12 months (\> 10 cigarettes/day) * administration of other investigational products within the last month * clinically abnormal findings at visit 1 * planned pgs/pgd/pbb or assisted hatching * concomitant participation in an other study protocol * history of extrauterine pregnancy in the previous 3 months * known allergy or hypersensitivity to progesterone or to any of the excipients (including peanut oil) of the additional study medication (gnrh agonist, vitrelle®, and utrogestan®) * presence or history of thrombophlebitis or thromboembolic disorders * presence or history of cerebral haemorrhage * presence or history of porphyria

Keywords: assisted reproductive treatment superovulation follitropin alfa r-hfsh afolia
understanding the impact of death conditions linked to the covid-19 crisis on the grieving process in bereaved families

Conditions: Psychological Disorder

Summary: this study aims to analyze the grieving process of people who have lost a close first degree relative, understand the impact of death conditions and model a "theory of mourning" in the context of the covid-19 crisis .

the covid-19 pandemic has confronted us with an unprecedented health crisis, this had major consequences on mental health . international literature has already shown an increase in psychological and psychiatric distress in patients followed in psychiatry, and in the general population. for bereaved relatives, certain factors contribute to complicate the mourning process, such as: the absence of communication with the healthcare team, the prohibition of visits, the absence of funeral rites... in the proposed research, we will analyze the grieving process of people who have lost a close first degree relative in children and adolescents population, understand the repercussions conditions of death in bereaved families and model a "theory of mourning" in the context of the current epidemic health crisis.

Eligibility criteria:
inclusion criteria: * bereaved person who lost a close relative (child, adolescent, adult) since march 2020 * age over 15 years old * first degree relative (husband-wife or equivalent, father-mother, son-daughter, brother-sister) * a bereaved person who is in at least one of the following conditions: * unable to visit the hospital if hospitalized or * unable to travel to the home/ephad/hospital or * wish not to travel for personal reasons or * failure to perform funeral rites or * failure to respect the wishes of the deceased and his or her own wishes or * inability to see the deceased or * opportunity to participate in the funeral or * unable to say goodbye or * inability to communicate via telephone and/or smartphone or * unable to repatriate the body to the country or region of origin * relative who died (child, adolescent, adult) between march 2020 and march 2021 with covid-19 or other life-threatening conditions * relative who died in an inpatient or outpatient setting (ephad, home or other structure) * french or non-french speaking bereaved person exclusion criteria: * presence of a pathology preventing good elocution during the interview: * presence of a neurological pathology (e.g. dementia, alzheimer's, aphasia, dysphasia) * presence of an unstabilised psychiatric disorder * person under guardianship or curatorship

Keywords: covid19 related psychological disorders
digital care chains in health care - a study of care consumption, care quality, work environment and well-being

Conditions: Depression; Depressive Disorder; Depressive Disorder, Major; Depression, Bipolar; Depression Recurrent

Summary: digital healthcare has developed rapidly to meet demands for accessible healthcare, streamline care and meet future challenges with increasing healthcare needs and reduced labour force in sweden. developers and stakeholders in sweden want to exchange the praxis of phone triage to digital or semi-digital triaging tools, to relieve staff's workload and utilize better resource use that would benefit all patient groups. however, previous studies have showed demographic differences in utilization rate and an increase of simpler care matters when digital healthcare options are offered. also, little is known of medical accuracy of digital triage tools and of the work environment in digital healthcare. more research is needed on this, as well as on care consumption, care quality and of patients' experiences of digital healthcare. the overall aim of the research project is to study a new digital healthcare platform being introduced in 2021/2022 in the county of gävleborg, sweden. the studies will focus on care consumption, healthcare outcomes, care quality and patient safety as well as explore the digital work environment in the digital healthcare platform. data will be collected before and after the introduction of the digital healthcare platform, using register data and questionnaires. the data from the two time periods will be analyzed with descriptive and inference statistics, to explore if the digital healthcare platform has brought differences on group levels in care consumption, healthcare outcomes, care quality and patient safety as well as in work environment aspects such as the staffs' well-being.


Eligibility criteria:
inclusion criteria in the patient study: * severe depression * has received inpatient care in the county of gavleborg during two given time-periods exclusion criteria in the patient study: * stress-related exhaustion disorder * substance use disorder * neuropsychiatric disorder * psychosis * postpartum depression. inclusion criteria in the staff study: * healthcare staff from all clinical areas in the county of gavleborg * staff with permanent employment exclusion criteria in the staff study: * administrative staff * managers * staff on long term leave * staff on long term sick leave * staff on parent leave * staff expected to retire or resign within a year

Keywords: telemedicine ehealth telecare telehealth hit