Kornimate/medical-research-clean huggingface dataset:
validation of a nutrition screening tool

Conditions: Adenocarcinoma of the Gastroesophageal Junction; Cervical Cancer; Endometrial Cancer; Esophageal Cancer; Fallopian Tube Cancer; Gastric Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer

Summary: the objective of this study is to evaluate the sensitivity and specificity of two nutrition screening tools to identify inpatients with malnutrition or at risk of malnutrition. the two tools are the royal marsden abridged adult nutrition screening tool (aanst) and the malnutrition screening tool (mst)\[10\] the tools will be compared with the currently accepted gold standard, patient generated subjective global assessment (pg-sga). both screening tools are in the form of scored questionnaires and are suitable for electronic input. the ultimate objective is to select an adult inpatient nutrition screening tool with the highest sensitivity for future use in the oncology inpatient setting in order to allow prompt commencement of an appropriate nutrition care plan.


Eligibility criteria:
inclusion criteria: * all adult inpatients, over the age of 18, admitted to rmh for whom a measured weight and height can be obtained exclusion criteria * patients for whom it is not possible to obtain a measured height and weight * people with a definitive diagnosis of dementia * people who lack capacity to understand the purpose of the study and to consent * patients who are unable to understand and speak english
alpha lipoic acid on clinical and electrophysiological recovery in carpal tunnel syndrome undergoing surgical release

Conditions: Carpal Tunnel Syndrome

Summary: the main purpose of this study is to determine the effectiveness of use alpha lipoic acid before and after surgical release of carpal tunnel syndrome. controlled clinical trial.

the main purpose of this study is to determine the effectiveness of using an oral supplementation of alpha lipoid acid to improve clinical and electrophysiological recovery after carpal tunnel release surgery. this research is designed as a double blinded clinical trial, with a calculated sample size of 40 patients, divided in two groups of 20 (a placebo, b alpha lipoid acid). all patients will undergo open carpal tunnel release surgery, the procedure will be performed by an expert surgeon. a total of four visits will be performed as follows: t0. baseline 4 weeks before surgery, t1 immediately before surgery, t2: 4 weeks after surgery, t3: 8 weeks after surgery, t4: 12 weeks after surgery. the assessment to be perform on each visit includes: physical examination, boston questionary for carpal tunnel syndrome. nerve conduction study and ecographic evaluation will be performed on visits t0, t1 and t4. statistical analysis: categorical variables will be assessed as counts and percent frequency and compared using the chi-squared test. all statistical analyses will be performed using the spss 21.0 package (spss inc., chicago, il, usa). a two-tailed p value \< 0.05 was considered statistically significant.

Eligibility criteria:
inclusion criteria: * clinical and electrophysiological diagnosis of carpal tunnel syndrome exclusion criteria: * rheumatic diseases * distal radio or carpal fractures. * pregnant women * alpha lipoid acid allergy * local injections (ej. steroid carpal injections) * peripheral nervous system diseases (which may cause nerve conduction study abnormalities).
safety study in outpatient japanese children with adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: evaluate the safety and efficacy of atomoxetine in japanese pediatric patients with adhd.


Eligibility criteria:
inclusion criteria: * patients must be 6 - 18 years of age * patients must meet dsm-iv diagnostic criteria for adhd * patient must be able to swallow capsules * patients must be of normal intelligence * laboratory results must show no significant abnormalities exclusion criteria: * patients who weigh less than 15 kg or more than 75 kg at study entry * patients who have a documented history of bipolar disorder or any history of psychosis * patients taking any antipsychotic medication within 26 weeks of visit 1 * patients with a severe history of allergies * patients taking methylphenidate
tunneled peripherally inserted central catheter (picc) in adult patients and associated outcomes

Conditions: CLABSI - Central Line Associated Bloodstream Infection; Deep Vein Thrombosis; Dislodged Catheter; Occlusion; Catheter Rupture; Catheter (Other); Complications

Summary: the aim of this multicenter randomized clinical trial is to compare the tunneling technique of picc insertion with the non-tunneled insertion technique in the incidence of the combined or isolated outcome of catheter-related bloodstream primary infection, thrombosis, obstruction, and accidental dislodgement in the adult population within a period of up to 30 days.

the data published this year from a multicenter study in brazil presenting the patterns of use and clinical outcomes of picc indicated that centers with vascular access teams, adoption of best practices, and current technologies result in low rates of complications, such as primary bloodstream infections related to the catheter, deep vein thrombosis, and reversible occlusion. despite these more recent data showing that complications related to picc can be mitigated by the use of technology, vascular access teams, adoption of best practices, and infection control measures, there is still room to incorporate new techniques in picc insertion with the aim of further reducing avoidable complications. for example, recent studies with robust methodology have demonstrated the benefit of the tunneling technique compared to the conventional insertion technique. a randomized clinical trial showed that the dwell time of the device inserted using the tunneling technique was longer compared to the conventional technique without tunneling in adult patients, along with a lower incidence of thrombosis and infection. at the hospital de clínicas de porto alegre, recently, nurses from the picc team were trained in the tunneling technique at a reference center in brazil. the initial results of tunneling in adult, pediatric, and neonatal patients are encouraging. the observed results of implementing the technique indicate that there is potential to reduce avoidable complications and prompt us to propose a multicenter randomized controlled trial involving two additional institutions with similar profiles regarding the composition of vascular access teams, adoption of best practices related to catheter care, and active ongoing education. to our knowledge, robust studies of this nature are not currently being conducted in brazil.

Eligibility criteria:
inclusion criteria: * adult patients (\>= 18 years old) admitted to medical clinics, surgical clinics, or icu, who have an indication for picc insertion; exclusion criteria: * patients with chronic kidney disease, whether dialytic or not; * patients in critical or unstable condition characterized by the need for intubation, respiratory rate \ 35 breaths per minute, oxygen saturation \ 140 beats per minute, systolic blood pressure \ 2 points, or prolonged (\>5 minutes) or repeated seizures; * patients with cognitive deficits that impair their understanding of the study and do not have a responsible party to assist in this stage.
topical ruxolitinib evaluation in chronic hand eczema

Conditions: Hand Eczema

Summary: the purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in adult participants with diagnosis of chronic hand eczema (che) and moderate to severe disease activity (investigator's global assessement (iga) of che score 3 or 4).


Eligibility criteria:
inclusion criteria: * diagnosis of che for at least 6 months prior to screening. diagnosis of chromic hand eczema (che) as defined by hand eczema (he) lasting \> 3 months or ≥ 2 flares within the previous 12 months. * screening and baseline iga-che 3 or 4. * baseline che-related itch nrs ≥ 4. * have been treated with at least 1 prescription che therapy or if such therapy was not advisable or contraindicated. * willingness to avoid pregnancy or fathering children based on the criteria defined in the protocol. exclusion criteria: * known triggers for che (allergic or irritant, such as those identified by previous patch tests) cannot be avoided during the course of this study. * any serious illness or medical, physical, or psychiatric condition(s). * laboratory values outside of the protocol-defined criteria. * use of protocol-defined treatments within the indicated washout period before baseline. * psoralen ultraviolet a (puva) or ultraviolet b (uvb) therapy on the hands within 4 weeks before baseline. * pregnant or lactating participants, or those considering pregnancy during the period of their study participation. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: eczema chronic hand eczema (che) dermatitis skin disease jak inhibitor
gastric ph in critically ill patients

Conditions: Critically Ill Patients; Indication for Stress Ulcer Prophylaxis

Summary: h2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. various studies demonstrated superiority of proton pump inhibitors over h2-receptor antagonists in increasing gastric ph and in healing gastric acid-dependent diseases. it is unknown, whether proton pump inhibitors are more effective in increasing gastric ph than h2-receptor antagonists in critically ill patients requiring stress ulcer prophylaxis.

gastric ph is measured continuously for 72 hours with a pipolar microelectrode placed between 7 and 15cm below the lower esophageal sphincter.

Eligibility criteria:
inclusion criteria: * critically ill patients * indication for stress ulcer prophylaxis * gastric ph \< 4 exclusion criteria: * gastrointestinal bleeding * gastric ph \> 4
comparison of the effects of abdominal massage and kinesio taping in women with chronic constipation

Conditions: Constipation

Summary: the aim of this study is to compare the effects of abdominal massage and kinesio taping on constipation severity, quality of life, bowel habits and perception of recovery in women with chronic constipation.

constipation is not a disease but a subjective symptom characterized by inadequate defecation, the definition of which varies from person to person. it is known that abdominal massage, which is one of the physiotherapy approaches, reduces the severity of gastrointestinal symptoms and increases bowel movements. kinesio taping applied for constipation can also increase bowel movement, increase the frequency of defecation and decrease the duration of defecation. however, there is a need for studies comparing the effects of these two different applications.

Eligibility criteria:
inclusion criteria: * 18 to 65 years of age * having been diagnosed with chronic constipation according to the rome 4 diagnostic criteria by a gastroenterologist * being volunteer exclusion criteria: * concomitant colon or gastrointestinal problems * body mass index \>35 kg/m2 * those who have difficulty defecating, those with anorectal dyssynergia * being pregnant * having neurological, metabolic and/or malignant disease * having an open wound, mass, infection and/or hernia in the area to be massaged * having abdominal surgery or abdominal radiotherapy in the last 1 year * having a mental problem that prevents cooperation * taking laxative therapy at least 4 weeks before participating in the study * to have received physiotherapy and rehabilitation applications related to constipation in the last 1 year
a phase i/ii study of bi-505 in conjunction with autologous stem cell transplant in multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of this study is to investigate the safety and efficacy of administering bi-505 in conjunction with high dose melphalan and stem cell transplantation in multiple myeloma patients.

n/a study is closed

Eligibility criteria:
inclusion criteria: * a diagnosis of multiple myeloma by 2014 imwg criteria and have been recommended to undergo hdm + asct as a standard-of-care therapy for their multiple myeloma. * subjects must have adequate vital organ function and functional status for hdm + asct * subjects must have collected and cryopreserved ≥4x106 hematopoietic stem cells per kg of actual body weight that are suitable for use in autologous stem cell transplantation in the judgment of the investigator. * at the time of enrollment, subjects must have had at least a partial response, as defined by imwg criteria and in comparison to baseline/pre-treatment parameters, to an induction regimen containing lenalidomide and/or bortezomib. * subjects must have measurable disease according to one of the following criteria: 1. serum m-spike ≥0.1 g/dl 2. urine m-spike \>200 mg in a 24-hour urine collection 3. involved serum free light chain above the upper limit of normal and a serum free light chain ratio outside the normal range. * at the time of enrollment, subjects must be within 12 months of the first dose of initial/induction therapy, and the anticipated day of asct must be within 12 months of the first dose of initial/induction therapy exclusion criteria: * prior allogeneic or autologous hematopoietic stem cell transplant * current active infections, including hiv and hepatitis c and b * autoimmune disease requiring ongoing immunosuppressive therapy. * history of atrial fibrillation or flutter, including paroxysmal atrial fibrillation or flutter. * history of transient ischemic attack or stroke. * at the time of enrollment, subjects must not have required multi-agent continuous-infusion cytotoxic chemotherapy (e.g., regimens such as d-pace) as part of their initial/induction therapy.
cerebral prophylactic irradiation with saving hippocampus and amygdala

Conditions: Non Small Cell Lung Cancer

Summary: hippocampus and amygdala are parts of the brain involved in the recognition of emotions, memories, memory, language ... it is therefore very important to protect them during irradiation of the brain. the aim of this study is to evaluate cerebral irradiation with saving hippocampus and amygdala protects these brain functions in patients with small cell lung cancer (sclc) radiotherapy of the brain


Eligibility criteria:
inclusion criteria: * patients over 18 years of age * patients with a limited sclc demonstrated histologically responsive or stable to radiochemotherapy or patients with a histologically proven extended sclc responding to chemotherapy. * who performance index 0-1 and / or karnovsky index\> 70 * possibility of long-term monitoring exclusion criteria: * concomitant chemotherapy * impossibility of performing an mri or ct without injection * presence of cerebral metastases * history of cerebral irradiation at any time * patient suffering from severe collagenosis * patient with cognitive disorders with mmse score \<24
co2 inhalation as a new treatment modality for apnea of prematurity

Conditions: Apnea of Prematurity

Summary: the objective of the present proposed study is to discover whether, in the nursery setting, administration of low concentration inhaled co2 (0.8%) for a prolonged period (3 days) can make breathing more regular with less apneic time than that observed with administration of theophylline. the hypothesis to be tested is that inhalation of low concentration co2 (0.8%) will reduce apnea more effectively and will have fewer adverse side effects than theophylline.

1. to discover whether, in the nursery setting, continuous administration of a low concentration of inhaled co2 (0.8%) for a prolonged period (3 days) can make breathing in preterm infants more regular with less apneic time than that observed with theophylline. 2. to discover whether inhalation of low co2 decreases apneas, particularly prolonged apneas (\>20 seconds), more effectively than theophylline. 3. to discover whether short term (during hospitalization) and long term (2 years) adverse side effects are less pronounced with co2 than with theophylline.

Eligibility criteria:
inclusion criteria: * infants between 27 and 32 weeks gestational age hospitalized in the neonatal intensive or intermediate care units * significant apnea, defined as 5 or more self-resolved apneas, or 2 or more apneas requiring intervention over a 12 hr period exclusion criteria: * already on methylxanthine treatment * on supplemental oxygen, nasal continuous positive airway pressure (cpap) * had major congenital anomalies, sepsis, or other known causes of apnea

Keywords: apnea premature infant prematurity
cognitive processing therapy for syrian patients with ptsd

Conditions: Posttraumatic Stress Disorder (PTSD)

Summary: background: studies among syrian refugees showed high prevalence rates of ptsd. the objective of the present study was to investigate the effectiveness of cognitive processing therapy (cpt) in treating patients with posttraumatic stress disorder (ptsd) using a clinical trial. methods: data will be obtained through interviewing patients seeking for ptsd treatment. patients will be interviewed by a clinician and asked to complete the clinician-administered ptsd scale (caps-5), beck depression inventory (bdi-ii), beck anxiety inventory (bai). assessments will be conducted at baseline, 3-, and 12-months posttreatment. the primary outcomes will be the scores of caps, bdi-ii, and bai. results: we predict that cpt will result in greater reductions in caps scores.

although individuals with ptsd experience significant suffering, disability, and a challenging clinical course, there are still significant gaps in the evidence addressing effective treatment options. therefore, in the current study cpt will determine the effectiveness in treating syrian patients with ptsd. current study significantly adds to the existing literature. it is a novel study in egypt and adds to the literature.

Eligibility criteria:
inclusion criteria their nationalities are syrians * age older than 18 years and younger than 65, * patients meeting current diagnostic criteria for ptsd as defined in dsm-5 * have a good knowledge of english-language (reading, writing, and comprehension) because all assessments and therapy materials were in english exclusion criteria * having mental retardation * having schizophrenia (or any other psychotic disorders).

Keywords: cognitive processing therapy (cpt) posttraumatic stress disorder (ptsd) syrians
lipid lowering agents to limit lipid oxidation and activation of clotting system in nephrotic syndrome

Conditions: Nephrotic Syndrome; Hyperlipidemia

Summary: the purpose of this research study is to learn if using statin in patients with nephrotic syndrome could lower the risk of blood clots. nephrotic syndrome is a collection of signs and symptoms that occur when the glomeruli -the tiny filters that work in the kidney- leak protein in the urine. one of the symptoms associated with nephrotic syndrome is hyperlipidemia: too much bad cholesterol (ldl). this bad cholesterol could be linked to the increased risk of blood clots in patients with nephrotic syndrome. the study doctors would like to see if taking a statin drug to reduce the amount of bad cholesterol could reduce the risk of blood clots.

venous thromboembolic (vte) events are common in the nephrotic syndrome (ns) occurring in up to 30% of patients when systematically screened. the investigator proposes to explore a novel mechanism for the increased clot formation in ns. to date, the only consistently identified underlying risk factor for vtes is severe hypoalbuminemia related to the ns. the underlying pathophysiology related to vte in ns remains poorly understood and has previously been ascribed to dysregulation of pro- and anticoagulant clotting factors due to urinary protein losses and reflected by the low serum albumin. however, the direct evidence for this mechanism is inconsistent and relatively poor. another feature of ns is that of severe hyperlipidemia which also correlates with hypoalbuminemia. in other severely hyperlipidemic states (e.g. familial hypercholesterolemia), the level of oxidized low-density lipoprotein (oxldl) is markedly elevated. forms of oxidized ldl interact with monocytes and macrophages leading to expression of tissue factor (tf), a procoagulant molecule. furthermore, monocytes and macrophages activated in this fashion also release microparticles, small cell-membrane derived vesicles, that also express tf and participate in initiating intravascular clot formation. the investigator hypothesizes that the hyperlipidemia of the nephrotic syndrome leads to elevations in oxidized ldl and in turn, elevations in microparticle tissue factor (mp-tf) and its activity. the investigator also hypothesizes that serum albumin levels will inversely correlate with hyperlipidemia as well as oxldl levels and mp-tf activity. here, the investigator will study the effect of treatment with hmgcoa reductase inhibitors (statins) on ox ldl and mp-tf activity patients with ns.

Eligibility criteria:
inclusion criteria:• prevalent or incident patients of either sex, ages 18-70, with membranous nephropathy (mn) , focal segmental glomerulosclerosis (fsgs), or minimal change disease (mcd). * proteinuria ≥ 3.0 g/day by 24hr urine collection or urine protein/creatinine ratio ≥ 2. * hyperlipidemia as defined by fasting or direct ldl ≥ 150 mg/dl. - exclusion criteria:inability or unwillingness to comply with the study protocol and follow-up visits. patients unable to provide written consent will be excluded. -

Keywords: nephrotic hyperlipidemia oxldl kidney
the effect of foot reflexology after cesarean section

Conditions: Postoperative Pain; Gastrointestinal Motility Disorder

Summary: standardized, quality and evidence-based nursing care after cesarean section is important to prevent or minimize complications that may occur after cesarean section. this evidence-based care will contribute to the shortening of the recovery period of the mother, the early start of postpartum bowel movements, the decrease in the perceived pain level, and the increase in postpartum comfort, thus facilitating the adaptation to new life and roles. on the other hand, although a limited number of studies reported the effects of reflexology, no study investigating the effect of reflexology on pain, comfort level and gis motility developed after sd was found. in this study, it was aimed to determine the effect of foot reflexology on pain, intestinal motility and comfort after cesarean section. hypothesis(s): h1: foot reflexology after cesarean section reduces the level of pain perception. h2: foot reflexology after cesarean section increases intestinal motility. h3: foot reflexology after cesarean section increases postpartum comfort.


Eligibility criteria:
inclusion criteria * 18 and over, * performing sd under general anesthesia, * cesarean section at 37-42 weeks of gestation, * the only live sd made, * written / verbal communication can be established, * at least primary school graduate, * not having any problems during her pregnancy, * women who agree to participate in the study will be taken into the sample. exclusion criteria * being under 18 years old, * those who gave birth by cesarean section before 37-42 weeks of gestation, * having chronic constipation, diarrhea and using any laxative type medication, * having problems such as fractures, dislocations, arthritis, phlebitis, wounds, burns, fungus, eczema, inflammation in the foot tissue, * having cardiovascular system disease,

Keywords: cesarean section foot reflexology postpartum pain postpartum comfort nursing bowel problems