Kornimate/medical-research-clean huggingface dataset:
neuroendocrine tumors of old patients in the west of france

Conditions: Neuroendocrine Tumors

Summary: neuroendocrine cancer remains a poorly known entity. comprehensive treatment is multidisciplinary involving surgery, radiological and nuclear medicine, and medical. a national network for the management of sporadic and hereditary malignant neuro-endocrine tumor (renaten) is in charged of coordinating this specific care. this is part of the french national cancer institute (inca) rare cancer plan. the project is in the form of an analysis of elderly population (75 years or over) with a diagnosis of neuroendocrine cancer in the western part of the france (brittany, pays de loire, normandy, center and a part of new aquitaine areas) representing a population of more than 12 millions of inhabitants. oncogeriatric evaluations, specialized meetings, ...would be analysed in order to improve the care of rare cancer patients.


Eligibility criteria:
inclusion criteria: * 75 years old or over at the time of diagnosis * patient with g1/g2/g3 neuroendocrine tumor diagnosed by pathological analysis * patient whose medical file was examined by renaten (national network for the treatment of neuro-endocrine sporadic and hereditary disease tumor) meetings or other multidisciplinary consultation meeting between 01/01/2014 and 31/12/2017 * patient with care in private and public centers in the west of france exclusion criteria: * patient with cancer other than a neuroendocrine tumor * patient with a g4 neuroendocrine tumor * patient who has objected to the study and collection of his medical data * refusal of participation

Keywords: neuroendocrine tumors 75 y and over patients oncogeriatric follow-up oncologic care
bacterial properties with lofric® catheters during clean intermittent catheterization

Conditions: Neurogenic Bladder; Urinary Retention

Summary: the primary objective of our study is to examine characteristics of bacteria that are discovered in urine from pediatric patients that utilize either lofric® or non-lofric® catheters for self intermittent catheterization. the investigators hypothesize that the hydrophilic nature of the lofric® catheter will alter the microbial environment and reduce clinically significant urinary tract infections in patients with neurogenic bladder compared to a similar population using standard catheters. secondary outcomes will be comparing the incidence of clinical urinary tract infections between patients that use standard catheters and those that use lofric catheters. lastly, patient satisfaction using lofric catheters compared to standard catheters will be assessed.

the investigators will randomize patients with neurogenic bladder into 2 groups after the have been matched for age, gender and mobility. the first group will continue with their current intermittent catheterization system (a non-lofric® catheter) while the second group will receive sufficient lofric® catheters to complete the study. the investigators will collect the urine at the start of the study, and then at 3, 6, 12, and 18 months and sent for culture. if a child develops a urinary tract infection, the investigators will have the patient collect the urine and the urine will be cultured and the organism will be identified. using an existing bladder cell line, the investigators will inoculate the bladder cells with any bacteria that grows from any sample and then determine the interleukin-6 response of the bladder cell line following inoculation with the bacteria. this will determine if the initiate a high or low cytokine response which the investigators have correlated to clinical risk of symptomatic urinary tract infection the investigators will provide a patient satisfaction survey at the start of the study, prior to randomization and at the completion of the study to determine satisfaction with lofric® catheters.

Eligibility criteria:
inclusion criteria: * patients who perform clean intermittent catheterization on a regular basis exclusion criteria: * patients on daily continuous antibiotic therapy
analysis of therapy sequence in women with hr+, her2 - mbc in moscow: a multicenter retrospective observational study.

Conditions: Breast Cancer Stage IV

Summary: a assessment of the efficacy of first-/second-line endocrine therapies ± target therapies and chemotherapy in real-life of in patients with hormone receptor-positive (hr+)/her2-negative metastatic breast cancer has not yet been conducted in moscow. methods: observational, retrospective study carried out in oncology hospitals in moscow, in patients with hormone receptor-positive (hr+)/her2-negative metastatic breast cancer. the descriptive analysis will be conducted for patient characteristics, responses to treatment and treatment outcomes. this study will provide retrospective chart review of evidence on the use of therapy in routine clinical practice, with a focus in population of moscow

the combination cdk4/6 inhibitors (cdk4/6i) (palbociclib, ribociclib and abemaciclib) with endocrine therapy (et, i.e. aro- matase inhibitors (ai) or fulvestrant) has significantly increased objective response rate (orr) and progression-free survival (pfs) of first- and second-line treatments in patients with hormone receptor positive, her2 negative (luminal) mbc. now this combination is the standard treatment for luminal mbc. recommendation for endocrine therapy versus chemotherapy as first-line treatment of luminal mbc is endorsed by the main international guidelines such as asco and eso-esmo guidelines. endocrine therapy should be used as initial treatment except in cases of immediately life-threatening disease, tumors refractory to endocrine therapy, visceral crisis, or rapid progressive disease that mandate a high response rate treatment. the aim of this study is to provide real-life treatment patterns data for luminal mbc with a focus in population of moscow

Eligibility criteria:
inclusion criteria: * patient has a histologically and/or cytologically confirmed diagnosis of estrogen-receptor positive and/or progesterone receptor positive breast cancer based on the most recently analyzed tissue sample and all tested by local laboratory. er should be more than 10% er positive or allred ≥5 by local laboratory testing. * patient has her2-negative breast cancer defined as a negative in situ hybridization test or an ihc status of 0, 1+ or 2+. if ihc is 2+, a negative in situ hybridization (fish, cish, or sish) test is required by local laboratory testing and based on the most recently analyzed tissue sample. * patient has inoperable locally advanced or metastatic breast cancer * patient has adequate bone marrow and organ function * patient must be physically well enough that they are capable of treatment exclusion criteria: * patient has severe acute or chronic medical or psychiatric condition, including recent or active suicidal ideation or behavior, or laboratory abnormality that may interfere with the interpretation of study results * no clinical and anamnestic information or information about safety or information about effectiveness treatment

Keywords: hr +, her2-negative metastatic breast cancer
imaging studies with ge c-hawk gamma camera compared to routine clinical exam

Conditions: Coronary Artery Disease; Chest Pain

Summary: comparison study of myocardial perfusion spect imaging with current clinical use camera and new camera.

comparison study of myocardial perfusion spect imaging with current clinical use camera and new camera.

Eligibility criteria:
inclusion criteria: * referral for cardiac stress testing with spect myocardial perfusion imaging exclusion criteria: * refusal to provide written informed consent or lack capacity to provide informed consent

Keywords: myocardial perfusion imaging
analysis of emergency department (ed) volumes during natural disasters

Conditions: Dialysis; Trauma Related Injuries; Carbon Monoxide Poisoning

Summary: the 'analysis of emergency department volumes during natural disasters' retrospective study focuses on three specified populations including dialysis patients, trauma patients, and patients poisoned by carbon monoxide. these three populations have one commonality - hurricanes, ie. natural disasters, which is the exposure. causal associations and significant correlations will be explored in all three subgroups.


Eligibility criteria:
inclusion criteria: * patients with carbon monoxide poisoning in addition to trauma and dialysis patients admitted to the memorial hermann health system's (mhhs) emergency department (ed) 1 week pre- and post-hurricane ike's landfall to the city of houston, which was september 12, 2008. exclusion criteria: * patients with the specified conditions that were not admitted during the time interval allotted.
pharmacologic interaction between ifosfamide and aprepitant in treated patients with soft tissue sarcoma

Conditions: Soft Tissue Sarcoma

Summary: this trial is a multicentric study aiming to assess the evolution of the serum ifosfamide concentrations and its serum metabolites in patients treated for an soft tissue sarcoma and co-exposed to aprepitant. the study will be conducted on a population of patients treated with doxorubicin and ifosfamide. the aprepitant can be prescribed to patients from cycle 2, according to the current recommendations. doxorubicin, ifosfamide and aprepitant will be administered in the context of routine care. the follow-up during the treatment period and the clinical, biological and radiological assessments will be performed according to the standard of each centre. patients will be followed during the two first cycles of treatment. for the pharmacokinetic study, blood samples will be collected at different time points during the 2 treatment cycles.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. anatomopathologic diagnosis of soft tissue sarcoma (localized, local recidive or metastatic). 3. patient receiving doxorubicin and ifosfamide chemotherapy (treatment decided during multidisciplinary consultation meetings) (neoadjuvant, adjuvant or palliative treatment). 4. screening laboratory values must meet the following criteria: 1. hemoglobin \> 9.0 g/dl, neutrophils \> 1500/mm3, platelets \> 100000/mm3 2. creatinine clearance (mdrd formula) \> 60ml/min. 3. ast/alt \< 2.5 x uln (5 x uln in patients with hepatic metastasis). 5. evaluable disease (measurable per recist or not), if applicable. 6. patient must provide written informed consent prior to any study specific procedures. 7. patient affiliated to a social health insurance in france. exclusion criteria: 1. previous treatment with ifosfamide. 2. patient who has already started doxorubicin and ifosfamide treatment. 3. any medical condition that can increase the patient's risk 1. active infection 2. active hepatitis or cirrhosis 3. recipients of organ transplants or immunocompromised patients, including human immunodeficiency virus (hiv) infection 4. pregnant or breastfeeding women 5. any psychological, familial, geographical or sociological condition which does not allow to respect the medical follow-up and/or compliance to study procedure 6. patient protected by law

Keywords: soft tissue sarcoma ifosfamide aprepitant doxorubicin
effect of breathing exercises before coronary angiography

Conditions: Anxiety; Breathing Exercises

Summary: this research was designed as a pre-test-post-test controlled group randomized controlled interventional study to determine the effect of breathing exercises applied to patients undergoing coronary angiography for the first time on anxiety. patients were provided with an informed consent form, a personal information form and the beck anxiety scale. the beck anxiety scale was administered to the control group before and after the procedure. in the experimental group, the beck anxiety scale was administered before the procedure, and after providing breathing exercise education and application, the beck anxiety scale was completed after the procedure.

this research was designed as a pre-test-post-test controlled group randomized controlled interventional study to determine the effect of breathing exercises applied to patients undergoing coronary angiography for the first time on anxiety. the study population consisted of sbü kartal koşuyolu training and research hospital.when statistical power analysis was performed according to the g-power program in the sample group, a minimum of 34 experimental and a minimum of 34 control groups were used, considering data loss, 76 volunteer patients who met the inclusion criteria were studied. patients were provided with an informed consent form, a personal information form and the beck anxiety scale. the beck anxiety scale was administered to the control group before and after the procedure. in the experimental group, the beck anxiety scale was administered before the procedure, and after providing breathing exercise education and application, the beck anxiety scale was completed after the procedure. the 'dependent group t-test' technique was used for the analysis of data obtained from the scales used in the study, comparing pre-test and post-test scores of the intervention and control groups. also, the 'independent group t-test' was used for separate comparisons of pre-test and post-test scores of the experimental and control groups.

Eligibility criteria:
inclusion criteria: * were between 18-80 years old, * had never undergone coronary angiography before, * correctly and completely filled out the beck anxiety scale, * voluntarily agreed to participate in the study. exclusion criteria: * having a psychiatric illness * communication problems

Keywords: coronary angiography breathing exercises anxiety
induce (intellin diabetic foot) feasibility study

Conditions: Healed Ulcer

Summary: this is a novel feasibility study to test the participant acceptance and usability of a specifically designed smart phone app. it will also explore the effects of smart phone technology in improving self-referrals into the diabetic foot ulcer (dfu) service. furthermore, it will be explored if this increase in self-referrals will influence the outcome of people with diabetes who have recently had a healed foot ulceration.

the rationale behind this study is if the investigators can introduce a new technology (a smart phone app) which is acceptable to patients, engages them and prompts people to take preventative health behaviours then the investigators may be able to influence the low rates of appropriate self-referral. there is evidence that links poor glycaemic control and hypertension to dfus, so engagement in these areas of wider diabetes management needs to be reviewed, the latest national diabetes audit (nda) shows only 20% of people with type 1 and 42% of people with type 2 diabetes achieve the 3 nice standards for hba1c, bp and cholesterol. in addition, healthcare providers are being asked to investigate new systems that may increase patient engagement with and the uptake of the nice 8 annual care processes. the latest nda shows only 40% of patients with type 1 and 60% of patients with type 2 diabetes currently have all 8 .

Eligibility criteria:
inclusion criteria: * • 18 years of age will be screened to meet the eligibility criteria: * consultant or gp diagnosis of diabetes mellitus (type i or ii) , documented on the electronic patient record with hba1c greater than 48mmol/mol * history of a recent diabetes foot ulcer defined as being eligible for the national diabetes foot audit and classified as healed for at least 4 weeks and no more than 12 weeks * able to provide informed consent * has no reasons that they could not be part of the study for 12 months such as moving out the area for attending appointments or short life expectancy from a diagnosed illness * owns a smart phone exclusion criteria: * no smart phone * comorbidity such as poor eyesight which limits the use of smart phone * participation in an interventional study within the last 30 days * critical illness that prevents participating for a period of time

Keywords: diabetic foot
study of tai chi exercise and balance in persons with parkinson's disease

Conditions: Parkinson's Disease

Summary: patients practicing tai chi will exhibit significant improvements in primary outcome measures of balance, and secondary outcomes of gait, physical performance, unified parkinson's disease rating scale, falls, muscle strength.

the study is designed to determine the effects of tai chi training on balance and other functional outcomes in persons with parkinson's disease.

Eligibility criteria:
inclusion criteria: patients who have: * a diagnosis of idiopathic pd, with a disease severity rating of stage i to iv on the hoehn and yahr scale (hoehn \& yahr, 1967) * at least 1 score of 2 or more for at least 1 limb for either the tremor, rigidity, or bradykinesia item of the unified parkinson's disease rating scale (updrs) * stable medication usage * not participated in a structured exercise program (i.e., not involved in any routine, organized physical activity program lasting 30 minutes or more per day, such as a gym program or regularly scheduled instructor-led exercise class) in the previous 2 months * ability to stand unaided or walk independently; had a personal physician's or neurologist's clearance for participation; and had a willingness to be assigned to intervention conditions. exclusion criteria: patients who: * participate in any other behavioral or pharmacological research study * have cognitive decline (mini-mental state examination score, ≤ 24) (folstein et al., 1975) * have self-reported diagnosis of alzheimer disease or other severe neurological (stage iii and iv pd) * have evidence of progressive or debilitating conditions (metastatic cancer, severe heart or lung disease, crippling arthritis) or severe losses in vision and hearing that would limit their tolerance to testing and training procedures, that would interfere with study participation * are unavailable during the study period.
pain and anxiety during extracorporeal shock wave lithotripsy

Conditions: Urinary Tract Stones; Pain; Anxiety

Summary: investigators observed that during the extracorporeal shock wave lithotripsy (eswl) non-pharmacological methods used for reducing the level of the pain and anxiety among the patients with the urinary stones are not sufficient and the effectiveness of these methods is controversial. there are very few studies, which investigated the effects of music on the pain and anxiety during eswl. in addition, any randomized clinical trial related to the use of stress ball for relaxation and distraction on the reduction of pain and anxiety during lithotripsy has not been found in the relevant literature. investigators also evaluated that further evidence-based studies are necessary. thus, investigators aimed to investigate the effectiveness of stress ball and music for reducing the pain and anxiety of the patients during eswl in this study.

extracorporeal shock wave lithotripsy (eswl), used commonly in urinary stone treatment, can cause pain and anxiety for patients. the aim of this study was to investigate the efficacy of use of music and stress ball to reduce pain and anxiety during lithotripsy. this was a single center parallel-randomized controlled trial. the study sample consisted of a total of 120 patients who applied to lithotripsy unit of urology clinic in a training and research hospital in turkey between april and september 2014. the patients were randomly divided into three groups. the patients in group-i (control group) were not interfered, while group-ii was given stress ball into their palms in order to squeeze and group-iii was listened to the music chosen by themselves with a headset during the lithotripsy procedure. data were collected using the patient information form, visual analogue scale (vas), and state trait anxiety inventory (stai-sa).

Eligibility criteria:
inclusion criteria: * the inclusion criteria of this study were to have kidney or ureter stones eligible for the eswl procedure based on the european association of urology guideline, * to be the first lithotripsy treatment, * to be older than 18 years old, * to have the body mass index of 30kg/m2 or less, * not to be given analgesic before the procedure, * not to have renal colic just before eswl, * not to have any contraindication in terms of lithotripsy, * not to have ureteral stent. exclusion criteria: * to refuse to participate in this study, * not to meet the inclusion criteria.
pilot study for speculum free cervical cancer screening

Conditions: Cervical Cancer

Summary: the objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.

this project is to assess if the introducer, "calla", can be used in place of a speculum during a routine pap smear. for the patient arm, the introducer will be used in conjunction with standard of care procedures. the healthy volunteer arm will include taking the introducer home for a week to determine if each person can find their cervix without the help of a physician. as well as completing surveys on ease of use and demographics related to their medial history.

Eligibility criteria:
inclusion criteria: healthy female * aged 21-65 years * have had a pelvic exam * have conversational proficiency in english * highest level of education attained exclusion criteria: - pregnant women

Keywords: pap smear
a study using the lmc diabetes registry to learn more about chronic kidney disease (ckd) in canadian patients with type 2 diabetes (t2d)

Conditions: Chronic Kidney Disease in Type 2 Diabetes

Summary: in people with type 2 diabetes (t2d), the body does not make enough of a hormone called insulin or does not use insulin well. this results in high blood sugar levels. people with t2d are at a higher risk of having a condition called chronic kidney disease (ckd). in people with ckd, the kidneys become damaged and do not work as they should. people with ckd can have trouble breathing and often have swelling in their arms and legs, and high blood pressure. people who have ckd and t2d are more likely to have other medical problems, such as heart disease. there are many treatments available to patients who have ckd and t2d. but, researchers need more information about how doctors in canada are deciding which treatment to give these patients. in this study, the researchers will review health information from men and women with t2d who visited a doctor in 2019 and had check-ups for at least 6 months. the health information will be taken from a canadian registry (or database) owned by lmc diabetes \& endocrinology. the registry contains information from people that went to an lmc clinic. in this study, the researchers will learn how many of these people had t2d and ckd. they will learn the treatments these people received, and if they had other related medical problems. the researchers will also use surveys to ask the doctors about why they chose certain treatments.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of t2d as captured in the lmc emr system * assessed by an lmc endocrinologist between january 1, 2019 and december 31, 2019 * followed by an lmc endocrinologist for ≥ 6 months prior to inclusion in the cohort * informed consent to use patient medical record data for research purposes was provided among patients who meet the inclusion criteria, estimated glomerular filtration rate (egfr) ≤ 60 ml/min/1.73 m\^2 and/or urine albumin-to-creatinine ratio (uacr) ≥ 2 mg/mmol will be used to identify the cohort of patients with t2d and ckd exclusion criteria: - any patients with documented non-diabetic etiology for renal disease will be excluded from the numerator (number of patients with ckd and t2d) when determining the primary endpoint