Kornimate/medical-research-clean huggingface dataset:
before-after comparison of pharmacist drug therapy management in pediatric hypertension

Conditions: Hypertension; Blood Pressure

Summary: this study will measure the effect of a novel pharmacy practice model on pediatric patients with hypertension. in north louisiana, many patients have to travel to see subspecialists for treatment for hypertension and elevated blood pressure, which has many costs including direct medical costs, direct nonmedical costs, and indirect costs like missed time from work, school, or social obligations. also, many patients who have to travel to get to their appointments have a high rate of missed appointments, which can be bad for overall health. this study will use a pharmacist to perform collaborative drug therapy management with pediatric cardiologists to manage therapy for patients with hypertension or elevated blood pressure. patients will monitor blood pressure at home and follow up with the pharmacist by telecommunications. pharmacist drug therapy management and telemedicine have been studied separately, but this is the first study with pharmacist drug therapy management by telemedicine for pediatric patients. if this model is successful, it could be replicated in other rural areas to improve patient care and reduce healthcare costs.


Eligibility criteria:
inclusion criteria: * diagnosis of elevated blood pressure or hypertension. * physician decision to treat with drug therapy or lifestyle modifications and physician referral to pharmacist. * consent both to therapy with pharmacist and participation in study (note: in the state of louisiana, patients must provide consent to be treated in a collaborative drug therapy management program). * for patients younger than 18, informed assent and parental permission to participate in the study. for patients who turn 18 during the study, informed consent will be obtained on the first visit after they turn 18. * males and females; age 4-20 at enrollment * willingness to adhere to study regimen the same inclusion criteria will apply to control patients except that: * they will have been treated at the clinic for hypertension or elevated blood pressure during the control period. * a waiver of consent has been obtained for historical data. exclusion criteria: * physical preclusion to taking blood pressure, such as lack of limbs or any congenital or acquired anatomical defect preventing routine measurement of blood pressure * participation in another treatment or intervention study for hypertension during the study period * inability to speak english * for patients under 18 years old, not having at least one parent or guardian able to speak english * patients who are pregnant

Keywords: children adolescents young adults pediatric hypertension pharmacoeconomics pharmacist
study of serum levels of oxidative stress markers in ovarian hyperstimulation patients

Conditions: Ovarian Hyperstimulation Syndrome

Summary: the aim of the study is to determine serum oxidative stress status by ischemia modified albumin (ima), total antioxidant capacity (tac), total oxidative capacity (tos), oxidative stress capacity (osi), and serum malondialdehyde (mda) in patients with ohhs and control group. we also aim to reveal the association between serum levels of these factors and oocyte quality.

* patients included in this study were assisted reproductive technique (art) patients with moderate and severe ohss who were hospitalized for management * control patients are selected from patients without signs of ohss * all patients are administered luteal long protocol for controlled ovarian stimulation. pituitary down-regulation with sc injection of gnrh agonist (gnrh-a) (1 mg/day; lucrin, abbott laboratories, north chicago, il) that was started on day 21 of the previous menstrual cycle. subcutaneous administration of recombinant hfsh (gonal-f, laboratories serono s.a., aubonne, switzerland) at dosages from 150-225 iu/day is initiated on the second or third day of menstruation. * when there are at least two or three follicles \>17 mm in diameter, recombinant human chorionic gonadotropin (0.25 µgr ; ovitrelle im, serono, istanbul, turkey) is applied subcutaneously 34-36 hours before oocyte retrieval. * serum samples are collected on day of hcg for study and control group patients. * serum levels of ischemia modified albumin (ima), malondialdehyde (mda), total oxidative capacity (tos), total antioxidative capacity (tas) and oxidative stress capacity (osi) levels. * this is a case control study * statistical analyses will be performed using student t-test and fisher chi-square test. the correlations between the serums ima, tac, toc, osi, and mda levels will be examined in all study groups using spearman correlation analysis.

Eligibility criteria:
inclusion criteria: • patients in both groups are normoresponders or hyperresponders who will undergo assisted reproductive technology for male factor exclusion criteria: * known inherited or acquired thrombophilia * previous thromboembolism * previous, current or planned anti-thrombotic treatment * first degree relatives with known genetic thrombophilia * systemic diseases * smoking.

Keywords: ovarian hyperstimulation oxidative stress ima ohss icsi long agonist protocol tac tos osi mda
change in the ratio of mean platelet volume (mpv) to platellet(plt) in covid-19 pneumonia patients

Conditions: Coronavirus Infection

Summary: morbidity, mortality and progress depends on systemic inflammation especially in ards patients. previous studies claims that the proportion of mean platellet volume to platellet which can simply be determined with simple blood tests that are performed at admission, might predict the mortality in ards patients. covid-19 pneumonia has a very similar clinical outlook with ards. therefore we decided to research whether that proportion is legitimate for detecting the progress of covid-19 pneumonia or not.

covid-19 pneumonia is a spesific disease dispate its similarity to ards. there are nomorous of studies that mpv/plt ratio can predict the mortality, morbidity and the progress of ards. depending on the similarity of ards, mpv/plt ratio might predict the clinical progress of covid-19 pneumonia. we retrospectively recruited150 patients admitted to our institute -a tertiary center- with covid-19 pneumonia to our study. clinical based defining research, by march-may 2020, the patients over 18 years old who were in either intensive care or ward scanned retrospectively. the laboratory tests, chronic diseases , age and gender has been collected from the written resources and electronic data retrospectively. the patients who are diagnosed with covid\*19 pneumonia will be divided into two groups. the ones in the ward will be considered as mild clinical course, and the ones in the intensive care unit will be considered as severe clinical course. there will be an additional non covid individuals as a control group, which will consist 52 patients each. the ratio of mpv to plt will be calculated using admission hemogrames of these groups, and the significance of the statistical differences on determining the prognosis of the disease will be discussed. gpower 3 for mac os (faul, f., erdfelder, e., buchner, a., \& lang, a.-g. (2009). statistical power analyses using g\*power 3.1: tests for correlation and regression analyses. behavior research methods, 41, 11491160.) was used for istatistical power analysis.it was done using anova test between at least two independent groups. in order to provide enoughsample magnitude power, which is 0.8, it was calculated that each group should have 52 patients which makes at total of 156. the normal distribution of data will be evaluated using kolmogorov-smirnov test. parametric ones will be used in normal distrubitions, non-parametric ones will be uused in abnormal distrubitions. between the independent groups, mpv/plt ratio will be calculated using anova test. categoric data will be compared by pearson ki square test and the p values less than 0.05 will be considered as significant. we aim to have an opinion about covid 19-pneomonia prognosis at the admission of hospital.

Eligibility criteria:
inclusion criteria: * patients over 18 years old who hospitalized with diagnosis of covid-19 pneumonia between march and may 2020 exclusion criteria: * under 18 years old patients * patients with heamolytic diaseses

Keywords: covid-19, mpv/plt, pneumonia
disengagement in csc: identifying those at risk and addressing their needs

Conditions: First Episode Psychosis

Summary: maintaining treatment engagement is critical for first episode psychosis patients to experience gains possible with coordinated specialty care (csc). this study is designed to identify csc participants still receiving care but at high risk for disengagement and to intervene to prevent/delay disengagement.

in phase 1 of the project, we will confirm a model predicting factors associated with later disengagement from csc treatment. in phase 2, we will compare disengagement among high-risk individuals with a csc step-down intervention to that with standard csc care. the step-down intervention will use web-based telemedicine and a smartphone app, to decrease disengagement likelihood. high-risk participants identified by predictors found in phase 1 will be offered the intervention.

Eligibility criteria:
inclusion criteria: * enrolled into a csc program exclusion criteria: * none
epbonf : evaluation of the safety and effectiveness of a medical device aimed at guiding orbito-naso-frontal band surgery, for the treatment of craniostenoses

Conditions: Craniosynostoses

Summary: craniostenosis is a congenital disorder caused by early fusion of the cranial sutures between the skull bones, resulting in orbito-naso-frontal deformities. the damage is primarily aesthetic, but intracranial hypertension may also be observed. the treatment of craniostenosis involves surgery, to restore harmonious growth between the skull bones and the brain, and proper development of the latter. there are various surgical techniques for correction, based on remodeling of the upper forehead and the orbito-naso-frontal band (bonf). however, bonf reshaping is difficult to tailor to each individual child. in most cases, the surgeon performs the reshaping "freehand", without a template. the result is therefore subject to the surgeon's experience and judgment. a surgical instrument (template) has been developed to guide the surgeon in the ideal reshaping of the bonf in patients with anterior craniostenosis (anterior plagiocephaly and trigonocephaly), according to each child's specific morphology. the aim of epbonf research is to evaluate the benefits of using this template on the symmetry and angle of the bonf.


Eligibility criteria:
inclusion criteria: * children with anterior craniostenosis (organic trigonocephaly or anterior plagiocephaly), aged 4 to 24 months * procedure performed at besançon university hospital * written consent from both parents, or from one parent if there is only one, indicating that they have understood the purpose and procedures of the study, and that they agree to their child's participation in the study and to the study's requirements and restrictions. * affiliation with a french social security scheme or beneficiary of such a scheme. * pre-operative computed tomography scan and cone beam to measure the fronto zygomatic distance and naso-frontal angle in trigonocephaly, and to calculate the frontal process of the zygoma symmetry defect in organic anterior plagiocephaly. exclusion criteria: * legal incapacity or limited legal capacity of parent(s) * subject is in the exclusion period of another study or is on the "national volunteer list".
juice preference in the emergency department

Conditions: All Eligible ED Patients (Not Limited to a Particular Condition)

Summary: ed patients who are able to drink juice will be approached and asked their beverage preference.

once per week for 26 weeks, patients will be enrolled during a randomly selected 1-hour block. the random blocks will be assigned using stata. during these enrollment periods, all current ed patients will be screened by the treating physicians and research associates, excluding patients in the "special care" unit, where most patients are intoxicated with alcohol. eligibility for oral consumption of water and juice will be determined by treating physicians. patients who are deemed eligible to drink water or juice will be approached and asked their beverage preferences. their response will be recorded, and the beverage will be procured for them.

Eligibility criteria:
inclusion criteria: * all emergency department patients, of any age, who are cleared by their treating physician to drink juice, and are able to communicate a juice preference. patients are only enrolled during randomly selected 1-hour blocks once per week for 26 weeks. exclusion criteria: * previously enrolled in the study * patients who are placed in the "special care" unit of the emergency department, which generally cares for intoxicated patients.
tailored egoscue exercises in patients with lumbar radiculopathy

Conditions: Lumbar Radiculopathy

Summary: lumbar radiculopathy (lr), commonly sciatica, is characterized by inflammation of the lower back's nerve roots. it is typically caused by sensory disruptions that arise from the lumbar spine and extend downward below the knee. lr is marked by alterations in motor and sensory functions, such as radicular discomfort,functional performance paresthesia, or tingling in the lower limb. this research aims to explore the effects of tailored egoscue exercises on pain, functional performance and sleep quality in patients with lumbar radiculopathy

the study was a randomized controlled trial, total 54 patients were recruited from rayan medical center, gujrat by using probability convenience sampling technique and assigned into two equal groups .27 patients in group a (experimental group) did egoscue exercises while group b (control group) was provided with routine rehabilitation. in this study, age group between 45 to 65 pre-diagnosed with lumbar radiculopathy by a neurophysician was included. lasègue's test , bragard's test and slump test was performed as a screening tool in the study. exercises was performed for 40 minutes per day on 3 alternate days per week for 6 weeks.group a (experimental group) included 10 minutes of heat therapy and 30 minutes of egoscue training while at group b (control group) 10 minutes of heat therapy, gentle stretches \& core stabilization exercises for 30 minutes was performed. patients was assessed at three levels pre (at baseline), mid (after 3 weeks) and post level(after 6 weeks) . assessment tool was a numerical pain rating scale, rolland-morris disability questionnaire \& insomnia severity index (isi) to assess the outcome variable

Eligibility criteria:
inclusion criteria: * age 45-65 years * both male and female * lumbar disc herniation /lumbar radiculopathy secondary to l4/l5 and l5/s1 * patients diagnosed with lumbar radiculopathy by neuro physician * positive lasègue's test(slrt): positive if pain occurs when the hip is flexed at 30 and 60 or 70 degrees from horizontal. * positive bragrd's sign: applying ankle dorsiflexion after the straight leg raise (slr) with the knee extended causes pain. * positive slump test: positive if symptoms are increased in the slumped position and decreased as the patient moves out of neck flexion exclusion criteria: * received treatment for lbp in the past 6 months * practiced any kind of exercise or sports activity during the last 6 months * spinal tumors * infections * pregnancy * neoplasm

Keywords: egoscue excercises lumbar radiculopathy
tabcat brain health assessment in primary care

Conditions: Mild Cognitive Impairment; Dementia

Summary: efficient and user-friendly paradigms to detect cognitive impairment, including dementia are needed in primary care. the tabcat brain health assessment accurately detects cognitive impairment via an appealing tablet interface with automated scoring and emr integration. this study will evaluate the effectiveness of the paradigm on detection rates and other brain health outcomes via a pragmatic cluster randomized trial in 26 kaiser southern california primary care clinics.

twenty-six kaiser permanente southern california (kpsc) primary care clinics will be randomized in two waves to receive either the tabcat-bha paradigm or usual care. clinics have been matched in pairs by number of providers, median panel size, the racial/ethnic makeup of the patient panel, baseline rates of cognitive impairment diagnosis, rates of telehealth encounters, and percentage of members who are 65+ in the practice. the trial will be conducted over two 18-month waves, with six intervention practices in the first wave and seven intervention practices starting in the second wave. all patients seen at least once across these 26 practices will be included in the trial and the primary analyses will use data extracted from the emr. patients in the intervention practices will receive care in accordance with the tabcat-bha paradigm whereas patients in the control practices will continue with usual care workflows. the intervention will include a 6-month startup period during which the research team will partner with the physician leads to adapt the paradigm workflows to each practice and onboard the pcps, and then a 12-month steady state period when effectiveness on the primary and secondary outcomes will be measured. during the tabcat-bha paradigm intervention, pragmatically, primary care providers concerned that their patients are exhibiting signs of cognitive decline will refer them to clinical research associates located in the primary care clinics who will then perform the tabcat-bha tablet-based test either on the spot or as a scheduled procedure visit. the tablet-based test provides an automated scoring report that includes guidance for providers to identify reversible causes of cognitive impairment, involving a care partner, diagnostic disclosure, community and educational resources, and specialty referral including the option to refer the patient for a "brain health consultation" telephone call with a study nurse or social worker.

Eligibility criteria:
inclusion criteria: * patient with at least one encounter at an intervention clinic during the intervention period * age 18+ (limited to 65+ for primary analyses) exclusion criteria: * patients under the age of 18.

Keywords: primary care cognitive assessment
effect of fas and fas ligand polymorphisms on patients with platinum-based -treated malignant pleural mesothelioma

Conditions: Malignant Pleural Mesothelioma

Summary: to study the effect of polymorphisms in fas ligand gene promoter region (rs 763110) and fas gene (rs1800682) on platinum-based regimens used in treatment of malignant pleural mesothelioma (mpm)

this study tries to find a correlation between single nucleotide polymorphisms (snp) found in promoter region of fas ligand gene (rs 763110) and fas (rs1800682) and clinical outcome on patients with mpm treated with platinum-based agents as first line. the patients will have one of three following genotypes : thymine/thymine, thymine/cytosine or cytosine/cytosine (for fas ligand polymorphism) and adenine/adenine, adenine/guanine or guanine/guanine ( for fas polymorphism).

Eligibility criteria:
inclusion criteria: * patients with histologically confirmed malignant pleural mesothelioma * age of 18 years or more. * first-line chemotherapy with platinum-based agents exclusion criteria: * history of prior malignancy. * pregnancy or lactation or any other reason preventing him from taking platinum-based chemotherapy (ast more than 2.5\* upper limit of normal or serum bilirubin more than 1.5\* upper limit of normal)
new adjuvant chemotherapy of asymptomatic resectable primary lesion with unresectable liver-limited metastases

Conditions: Colorectal Neoplasms; Neoplasm Metastasis; Liver Neoplasms; Chemotherapy; Maternal, Affecting Fetus

Summary: to evaluate the survival benefit of pre-operation chemotherapy of primary tumor tesection (ptr) compared upfront ptr for colorectal cancer (crc) patients with an asymptomatic resectable primary tumor and synchronous unresectable liver-limited metastases with conversion therapy intent.

fast recovery with fewer postoperative complications, prevention of potential tumor-related complications during chemotherapy, life quality improvement, and also can alleviate the tumor load of patients, are some advantages of ptr that may play a role in improving cancer-specific survival. however, it should be pointed out that nearly all the retrospective and prospective studies for the beneficial of ptr enrolled more multi-organ metastases mcrc patients, and with palliative treatment purpose. as for unresectable colorectal liver-limited metastases (crlms) with good eastern cooperative oncology group performance status (ecog ps), the primary objective is to make metastases resectable by high-intensity conversion therapy and achieved a state of no-evidence of disease. ptr were preferred performed before enrollment in some related rct studies, including the celim study, cairo and cairo2 studies. pooled-analysis of our two rct studies, ptr pre or post chemotherapy for these unresectable liver-limited metastases patients had less morbidities and no mortalities, but no rcts have focused on survival benefit of pre-operation chemotherapy of ptr for unresectable crlms.

Eligibility criteria:
inclusion criteria: * age between 18 - 75 years old * colorectal adenocarcinoma pathologically * without any chemotherapy or radiotherapy * unresectable liver metastasis and without other metastasis * resectable colorectal cancer * suitable for chemotherapy * agreed by patients exclusion criteria: * age below 18 years old or greater than 75 years old * haven't pathological diagnosis of colorectal adenocarcinoma * with any chemotherapy or radiotherapy * resectable liver metastasis or without other metastasis * unresectable colorectal cancer * unsuitable for chemotherapy * not agreed by patients

Keywords: unresectable colorectal liver metastases pre-operation chemotherapy primary tumor resection survival
effect of neck extension on intraocular pressure in patients undergoing palatoplasty

Conditions: Cleft Palate

Summary: the purpose of this study is to investigate the change in intraocular pressure according to the neck extension during palatoplasty in pediatric patients.


Eligibility criteria:
inclusion criteria: * patients who have undergone a palatoplasty with cleft palate and who are 6 months or older and under 24 months * patients with asa class 1-2 * patients who agree to voluntarily participate in this study exclusion criteria: * patients who refused to participate in clinical studies * history of diagnosis of neurologic or ophthalmic disease * history of neurosurgery or ophthalmic surgery