Kornimate/medical-research-clean huggingface dataset:
serum calcium to phosphorous (ca/p) ratio in the diagnosis of ca-p metabolism disorders: a multicentre study

Conditions: Phosphorus and Calcium Disorders; Parathyroid Diseases; Hyperparathyroidism; Hypoparathyroidism

Summary: primary hyperparathyroidism (phpt) and hypoparathyroidism (hp) are two of the most frequent disorder of calcium-phosphorus (ca-p) metabolism. the ca/p ratio is an accurate tool to differentiate patients with phpt from healthy subjects, according to a previous single-centre study. the reliability of this index is based on the fact that serum ca and p are inversely related together either in healthy subjects or in patients with phpt and hp.

the aim of this study is to investigate the accuracy and diagnostic value of ca/p ratio in the diagnosis of primary hyperparathyroidism and hypoparathyroidism. the definition of a valid cut-off of serum ca/p ratio for patients with these disorders will be of help especially in those patients with apparently normal biochemical profile, but suggestive for primary hyperparathyroidism and hypoparathyroidism.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of primary hyperparathyroidism * patients with diagnosis of hypoparathyroidism * subjects with normal calcium-phosphorus metabolism exclusion criteria for both cases and controls will be: * age younger than 18 or older than 90 years * severe renal and liver diseases (i.e. glomerular filtration rate (gfr) \<30 ml/min) * hyperparathyroidism secondary to vitamin d deficiency * active metabolic bone disease (e.g. paget's disease of the bone, osteomalacia, rickets, etc) * any type of cancer * malnutrition * severe obesity (bmi \> 40 kg/m2) * a history of gastrointestinal malabsorption * sarcoidosis * hypercortisolism * diabetes insipidus * hyperthyroidism * pseudohypoparathyroidism * familial hypocalciuric hypercalcemia (fhh) * treatment with steroids, active forms of vitamin d (calcitriol, ergocalciferol, etc), thiazides, phosphate binders, lithium, cinacalcet, bisphosphonates, and denosumab.
vr homework exercises for selective mutism treatment

Conditions: Selective Mutism; Anxiety Disorder of Childhood

Summary: selective mustism (sm) is an anxiety disorder that manifests in childhood. children with children with sm do not speak in certain social situations where this is expected of them. for example, a child may talk at home, but is afraid to speak at school. the goal of this clinical trial is to determine the efficacy of behavioral therapy for children with selective mutism (sm) combined with virtual reality (vr) homework exercises. virtual reality exposure is an effective treatment for adults with anxiety disorders. the main questions to answer are: * is behavioral therapy combined with vr homework exercises effective in the treatment of sm? * which familial factors contribute to a positive treatment outcome and homework adherence? a single-case experimental design (sced) will be used to evaluate the efficacy of the treatment. the child's speaking behavior at baseline will be compared to the child's speaking behavior in the different phases of the intervention. participants will: * follow individual therapy sessions at school. * practice with the vr homework exercises at least once a week. * parents and teachers will evaluate the child's speaking behavior.

the treatment in this study consists of behavioral therapy for sm (with the protocol 'talking at school, a matter of doing') with the addition of the vr homework exercises. the protocol consists of 10 steps that help the child to gain confidence while speaking at school. the individual therapy sessions are provided at school. for every step of the protocol there are vr homework exercises available. families receive a vr headset for the duration of the study. parents are instructed to work on the vr homework exercises at least once a week and encouraged to work on the vr homework exercises several times a week. on average, treatment is approximately 25 weeks.

Eligibility criteria:
inclusion criteria: * the child meets the dsm-5 criteria for sm (as a primary classification). * the child is attending primary school. * referred to an academic center for child and adolescent psychiatry (levvel) for diagnosis and treatment of sm * psychiatric comorbidity is permitted, given that sm is the primary treatment target. * medication use is permitted, if stable for at least 4 weeks prior to the start of treatment. exclusion criteria: * no participating parents. * parents do not have sufficient mastery of the dutch language. * parents or child have an estimated iq below 75. * the child needs inpatient treatment. * children with a (medical) condition that is a contraindication for using a vr headset (epilepsy, claustrophobia, facial condition, sensitive vestibular system, panic attacks) * parents receiving parental guidance which is not part of the standard treatment program. * children that have received protocolled behavior therapy for sm in the past 12 months.

Keywords: virtual reality virtual reality exposure therapy intervention treatment children anxiety
effect of stretching exercises applied to diabetes patients physiological parameters

Conditions: Diabetes

Summary: this research will be carried out as a pretest-posttest randomized controlled study to determine the effect of stretching exercises performed 2 days a week for 12 weeks for one hour each session on physiological parameters and treatment compliance in individuals with diabetes.

this research will be carried out as a pretest-posttest randomized controlled study to determine the effect of stretching exercises performed 2 days a week for 12 weeks for one hour each session on physiological parameters and treatment compliance in individuals with diabetes.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. those who have been diagnosed with diabetes and have been on the same diabetes treatment for at least three months 3. non-pregnant 4. those who agreed to participate in the research 5. those without any physical exercise disability exclusion criteria: 1. illiterate 2. persons with severe mental disorders 3. those who do not wish to answer the survey questions 4. those who do not agree to participate in the research

Keywords: diabetes exercise blood sugar
gore tag® thoracic endoprosthesis - 45 mm for the treatment of aneurysms of the descending thoracic aorta

Conditions: Aortic Aneurysm, Thoracic

Summary: the objective of this study is to assess the safety and efficacy of the 45 mm tag device in subjects with aneurysms of the descending thoracic aorta.


Eligibility criteria:
inclusion criteria: 1. presence of descending thoracic aortic aneurysm deemed to warrant surgical repair * fusiform (≥50 mm), or * saccular (no diameter criteria) 2. all proximal and/or all distal landing zone inner diameters between 37-42 mm * diameter taper between proximal and distal landing zones and the ability to use devices of different diameters to compensate for the taper must be within device sizing guide specifications 3. proximal and distal landing zone length greater than 2.0 cm * landing zone must not be aneurysmal, dissected, heavily calcified, or heavily thrombosed 4. life expectancy \> 2 years 5. subject is open surgical candidate defined as: * able to tolerate thoracotomy * american society of anesthesiologists class i-iv (class v excluded) * new york heart association class i-iii or not applicable (class iv excluded) 6. male or infertile female 7. age greater than 21 years 8. able to comply with study protocol requirements, including follow-up exclusion criteria: 1. mycotic aneurysm 2. hemodynamically unstable aneurysm rupture 3. aortic dissection 4. planned occlusion of left carotid or celiac arteries 5. planned concomitant surgical procedure (other than left subclavian transposition), or major surgery within 30 days of treatment date 6. myocardial infarction or stroke within 6 weeks of treatment 7. pre-treatment creatinine \> 2.0 mg/dl 8. degenerative connective tissue disease, e.g. marfan's or ehler-danlos syndrome 9. participation in another drug or device study within 1 year of treatment 10. history of drug abuse within 6 months of treatment
effectiveness of perineorrhaphy in pelvic organ prolapse surgery

Conditions: Pelvic Organ Prolapse Vaginal Surgery; Pelvic Organ Prolapse (POP)

Summary: this is an observational registry-based study of long-term outcome after vaginal native tissue repair for pelvic organ prolapse designed to emulate a pragmatic open-label two-arm trial for which patients, in whom perineorrhaphy is not strictly indicated but clinically tenable, perioperatively are randomized to concomitant perineorrhaphy or not.

this is an emulated pragmatic open-label two-arm trial in patients undergoing native tissue repair surgery for pelvic organ prolapse, in which patients are randomized perioperatively to either concomitant perineorrhaphy or not. the target population is the large group of patients for whom, at the discretion of the surgeon, this intervention is currently an option while not being strictly indicated. the investigators assumed that women were randomly assigned perioperatively to either strategy within levels of baseline co-variables: age, bmi, parity, lung disease, asa-classification, constipation, hypermobility, prolapse in which vaginal compartment and if surgery is performed on it, year of primary surgery and region. data was obtained from the swedish national quality register of gynaecological surgery (gynop), the swedish national patient register, the swedish medical birth register, and the swedish cause of death register. in order to emulate a target trial, multiple imputation of missing data is followed by controlling for confounding through inverse probability weighting (ipw) in order to estimate the average treatment effect (ate) in the primary analysis. in the secondary analysis, the primary analysis will be repeated but with overlap weights. additional analyses: the sample will be re-weighted using ipw to estimate the average treatment effect on the treated (att). restricted mean survival time (rmst) will be calculated at five years of follow-up for the primary outcome. bias analysis: mortality during follow up for the primary outcome will be used as a negative control.

Eligibility criteria:
inclusion criteria: * pelvic organ prolapse surgery with vaginal native tissue repair without concomitant hysterectomy. exclusion criteria: * primary surgery with colpocleisis, use of mesh, laparoscopic or abdominal surgery, concomitant incontinence surgery (eg transvaginal tape). * previous hysterectomy * previous pelvic organ prolapse surgery

Keywords: target trial emulation pelvic organ prolapse perineorrhaphy vaginal surgery cystocele rectocele apical prolapse
risk factors and impact of anesthesia techniques on myocardial infarction following transurethral resection of the prostate

Conditions: Anesthesia; Transurethral Resection of Prostate Syndrome; Myocardial Infarction

Summary: this study examined the risk factors and the influence of the type of anesthetic used during transurethral resection of the prostate (turp) on subsequent incidence of myocardial infarction (mi).

this study utilized a population-based, nationwide dataset to evaluate the risk factors of mi for patients with benign prostate hypertrophy (bph) who received turp. besides, the study also compared the different effects of general anesthesia (ga) and neuraxial anesthesia (na) on the incidence of mi within 6 and 12 months after turp.

Eligibility criteria:
inclusion criteria: * patients receiving turp surgery (1998-2012) exclusion criteria: * patients without anesthesia records * patients receiving both general and neuraxial anesthesia * mortality within 12 months of turp
dementia caregivers and contemplative practice: a pilot study

Conditions: Loneliness

Summary: the goal of this study is to test the contemplative practice is feasible and acceptable among informal dementia caregivers population at all stages.

it will also examine the benefits of this intervention and compare the outcomes between two groups (intervention and wait-list control).

Eligibility criteria:
inclusion criteria: * dementia family caregivers * at least cared for dementia care receipient more than 6 months exclusion criteria: * if they have meditated less than 2 months ago * cognitive or language barrier that would make it difficult to understand and sign the informed consent
efficacy of t2259 in ded

Conditions: Dry Eye Syndromes

Summary: the purpose of this study is to compare the performance and safety of t2259 versus vismed multi in dry eye patients with superficial keratitis.


Eligibility criteria:
main inclusion criteria: * signed and dated informed consent * male or female aged from ≥ 18 years old * known dry eye syndrome requiring artificial tears within the last 3 months prior to study selection main exclusion criteria: * far best-corrected visual acuity≤2/10 * severe blepharitis
respiratory muscle strength, exercise capacity and physical activity levels in children primary ciliary dyskinesia

Conditions: Primary Ciliary Dyskinesia

Summary: primary ciliary dyskinesia is an autosomal recessive disorder characterized by abnormal ciliary movement and disrupted mucociliary clearance. in uncleaned airways, microorganisms and respiratory irritants cause inflammation and infection. permanent rhinitis and chronic sputum cough are typical features in primary ciliary dyskinesia patients. primary ciliary dyskinesia is a disease that threatens lung function from pre-school age. one of the main causes of respiratory muscle weakness in chronic lung diseases diseases is worsening of lung function. such a weakness causes alveolar hypoventilation, microatelectasis, reduction of the cough strength .the cough strength is important for airway cleaning. exercise capacity is affected in chronic lung diseases. assessment of exercise capacity in chronic lung diseases is prognostically important. reduced exercise capacity and pulmonary function in pcd cause decrease in physical activity level. pcd patients have low quality of life and early recognition has been found to affect the quality of life positively. children with chronic illness have higher level of depression than healthy children. in literature, no study investigated respiratory muscle strength, exercise capacity and physical activity pcd patients. therefore, the investigators aimed to compare aforementioned outcomes in pcd patients and healthy controls.

according to sample size calculation 26 diagnosed primary ciliary dyskinesia patients and 26 healthy individuals will be included. respiratory muscle strength, anaerobic and aerobic exercise capacity, physical activity, pulmonary functions, peripheral muscle strength, cough strength, respiratory muscle endurance, activity dyspnea perception, quality of life and depression will be evaluated. primary outcome measurements are respiratory muscle strength, exercise capacity, physical activity; secondary outcomes are pulmonary functions, peripheral muscle strength, cough strength, respiratory muscle endurance, activity dyspnea perception, quality of life and depression.

Eligibility criteria:
inclusion criteria: * diagnosed primary ciliary dyskinesia patients, * 6-18 years of age, * under standard medications, * stable patients without exacerbation or infection exclusion criteria: * having cognitive disorder, * orthopedic or neurological disease with a potential to affect functional capacity, * acute infections or pneumonia, * problems which may prevent evaluating such as visual problems

Keywords: exercise capacity respiratory muscle strength physical inactivity quality of life
a study evaluating oxybutynin in patients with neurogenic overactive bladder associated with a neurological condition

Conditions: Detrusor Hyperreflexia

Summary: this study will evaluate the efficacy and safety of an anticholinergic drug treatment administered by transdermal patch to treat overactive bladder in adults who have spinal cord injury.

the dose titration period began with a 3.9 mg/day or 7.8 mg/day as a starting dose after the completion of a 3-day diary for baseline evaluations, including urodynamic testing. the clean intermittent catheterization (cic) frequency remained constant throughout the dose titration period. the dose was adjusted every two weeks during the dose titration period by increasing one dose level, at the investigator's discretion, based on the patient's symptoms. if a patient achieved complete continence and reported tolerable or absence of side effects, the patient was continued at that dose for the duration of the 8-week titration period. if a patient reported unacceptable side effects, the dose was reduced by one level. this reduced dose was considered the maximum tolerable dose for the patient and the patient continued at that dose for the duration of the 8-week titration period. the dose levels evaluated were 3.9 mg/day, 7.8 mg/day, 9.1 mg/day, and 11.7 mg/day. of the 22 subjects in the modified intent-to-treat population evaluated for efficacy, 0 were in the 3.9 mg/day dose group, 3 were in the 7.8 mg/day dose group, 8 were in the 9.1 mg/day dose group, and 11 were in the 11.7 mg/day dose group.

Eligibility criteria:
inclusion criteria: * at least 18 years of age at day of consent; * is a male, or is a non-pregnant non-lactating female who is either of non-child-bearing potential, or is using adequate means of birth control; * has a h/o of urinary incontinence from neurogenic bladder of spinal cord injury etiology; * has impairment based on the american spinal injury association (asia); * use clean intermittent catheterization; * has urinary incontinence between scheduled catheterization; * capable of understanding and complying with the protocol. exclusion criteria: * have one or more treatable conditions, other than neurogenic bladder dysfunction, that may cause urinary incontinence or urgency; * have any medical condition that precludes their participation in the study, or may confound the outcome of the study; * history of major lower urinary tract surgery, procedures; * has an active skin disorder, affecting tds application site areas; * hypersensitivity to the investigational drug; * has participated in any study involving administration of an investigational compound within 30 days before this study.
effect of dianatal obstetric gel (cross-linked polyacrylic acid) on outcomes in vaginal delivery

Conditions: Labor, First Stage; Labor, Second Stage

Summary: perineal massage at the end of labor stage 2 has been investigated in 2 randomized controlled trials using a water soluble lubricant. in one trial a significant reduction of labor stage 2 has been found, both trials did not show a significant increase of perineum integrity. in the hcb swiss study both a significant reduction of labor stage 2 by 30 % as well as a significant increase of perineal integrity have been shown. no adverse events have been reported. (see also obstetric gel shortens second stage of labor and prevents perineal trauma in nulliparous women: a randomized controlled trial on labor facilitation. schaub af, litschgi m, hoesli i, holzgreve w, bleul u, geissbuhler v. j perinat med 2008; 36 (2): 129-135). today's practice- lubricants are widely used to enable manual vaginal examination during labor. in israel midwifes are using almond oil for perineal massage at the end of labor stage 2 to protect the perineum. it has been shown for the first time that the use of the dianatal obstetric gel facilitates vaginal childbirth in humans. dianatal has been introduced to the eu markets in 2008.


Eligibility criteria:
inclusion criteria: * maternal age between 18 and 40 years * signed written informed consent, * intention for vaginal delivery, * nulliparous state or multiparous state * singleton baby in vertex presentation * estimated birth weight between 1500 g and 4500 g * low risk pregnancies at term and late preterm (34 to 42weeks of gestational age) exclusion criteria: * contraindications for vaginal delivery * indications for an amnion infection syndrome * suspect for fetal malformations * indications for cephalopelvic disproportion * severe concomitant diseases of the mother
lus in acute heart failure therapeutic adaptation

Conditions: Acute Heart Failure; Pulmonary Congestion

Summary: evaluate lung ultrasound aspect according to diuretics dosage evolution in patients hospitalized for acute heart failure.

eppica is an observational and prospective cohort study. the study goal is to evaluate lus aspect evolution according to diuretics dosage in patients hospitalized for acute heart failure.

Eligibility criteria:
inclusion criteria: * acute heart failure diagnosed by a senior physician in the medical department, with a confirmation of a second senior physician. * hospitalised in the medical department. * no objection from the patient of his trusted person. exclusion criteria: * administrative supervision or deprived of their liberty * pulmonary conditions distracting lung ultrasound (pneumonectomy, pulmonary fibrosis) * chronically dialysed

Keywords: lung ultrasound diuretics medical department
better sleep in psychiatric care - bipolar

Conditions: Sleep Problem; Bipolar Disorder

Summary: cognitive behavioral therapy (cbt) is treatment of choice for insomnia. many patients in psychiatric care have sleep problems including insomnia, but are rarely given the choice to participate in cbt to improve their sleep. patients with bipolar disorder is a patient group with high levels of sleep difficulties. sleep problems in this patient group can be both more general such as insomnia, but can also be related to the bipolar disorder. other research groups have studied the use of behaviorally sleep treatments in patients with bipolar disorder, but more studies are needed. in a previous pilot study, the investigators of the current study developed a cbt protocol that would target sleep problems in this population. the basis was cbt for insomnia (cbt-i), but with more emphasis on achieving sleep promoting behaviors specific to bipolar patients, for instance techniques that would also alleviate sleep phase problems, (e.g. the systematic use of light and darkness), and techniques to target more general sleep related problems (e.g. difficulties waking up in the morning), that are also common in patients with bipolar disorder. this treatment was well tolerated and gave moderate effects on insomnia severity in the pilot study. in a naturalistic randomized controlled trial, the investigators now evaluate the effects of this psychological treatment on sleep and bipolar symptoms in patients at the departments of affective disorders, northern stockholm psychiatry and southwest psychiatry, stockholm, sweden.


Eligibility criteria:
inclusion criteria: * being a patient at the clinics involved in the project * experiencing sleep problems (subjective report) * being able to participate in a psychological intervention in group format exclusion criteria: * night shift work

Keywords: cognitive behaviour therapy psychological intervention