Kornimate/medical-research-clean huggingface dataset:
effects of community-based caring contact on post-discharge young adults with self-harm

Conditions: Self Inflicted Injury; Suicide and Self Inflicted Injury

Summary: the study will determine whether community-based caring contact via a mobile app connection with or without volunteer support in addition to treatment as usual (psychiatric and psychosocial treatments) has an effect on suicidal ideation and treatment compliance among post-discharge self-harm young adults.

the proposed study will determine whether community-based caring contact via a mobile app connection with or without volunteer support in addition to treatment as usual (tau; psychiatric and psychosocial treatments) is effective in reducing suicidal ideation, enhancing treatment compliance, reducing thwarted belongingness and perceived burdensomeness and hopelessness among post-discharge self-harm young adults, and if personalized contact by volunteers has additional effects reducing suicidal ideation among post-discharge self-harm individuals. 108 participants aged 18-45 with an index self-harm episode will be recruited from the accident \& emergency department (aed) of 4 local public hospitals, and randomized into the tau, mobile app group with, and without volunteer support. each participant will complete a questionnaire at the 4 measurement time points at baseline (t0), one-month (t1) and the end of the 2-month intervention period (t2), and post-intervention at the three-month point (t3) from the baseline. the primary outcomes include suicidal ideation, hopelessness, thwarted belongingness \& perceived burdensomeness, treatment (tau) compliance, and suicidality.

Eligibility criteria:
inclusion criteria: * individuals with an index episode of self-poisoning or self-injury with or without suicide intent, based on the icd-10 codes for self-harm with and without suicide intent (i.e., x60 to x84 and r45.8) * admission to the aeds at the 4 collaborating public hospitals in hong kong (united christian hospital, north district hospital, queen mary hospital, and pamela youde nethersole eastern hospital) * mentally well assessed by a psychiatrist or consultation liaison nurses (clns) * capable of providing written informed consent form exclusion criteria: * individuals with dsm-iv-tr axis ii disorder; or * individuals with severe psychotic mental illness or bipolar disorder
standard vs. reduced-intensity conditioning in patients with acute myeloid leukemia in first remission

Conditions: Acute Myeloid Leukemia

Summary: the primary goal of the study is to show that the treatment-related mortality of allogeneic hematopoietic stem cell transplantation an be significantly reduced by using a combination of 8 gy total-body-irradiation and fludarabine in comparison to the conventional combination of 12 gy tbi and 120 mg/kg cyclophosphamide.

transplant-related deaths because of extramedullary toxicity and graft-versus host disease remain the major causes for treatment-failure in patients with aml receiving allogeneic hematopoietic stem cell transplantation. in phase ii study, m . stelljes and coworkers could show, that a reduced dose of total-body- irradiation and fludarabine can be safely used in patients with aml at various disease stages. the best results could be achieved in patients who had been in complete remission by the time of inclusion. therefore this prospective trial was initiated to compare the new conditioning regimen with the standard regimen of 12 gy tbi/cyclophosphamide 120 mg/kg in patients ith aml in first remission. after having achieved complete remission, and giving informed consent, patients are stratified according to marrow cytogenetics, age and type of induction therapy and subsequently randomized to receive on of the mentioned conditioning therapies. the primary end-point will be non-relapse mortality. the hypothesis would be, that the one-year mortality can be reduced from 25 to 15%. given a power of 0.8 and a first-error of 5%, 252 patients will have to be randomized. secondary endpoints include: 3 year overall-and disease-free survival rate of grade ii-iv acute gvhd rate of grade 3-4 extramedullary toxicity

Eligibility criteria:
inclusion criteria: * diagnosis of acute myeloid leukemia in first remission * standard-or high-risk marrow cytogenetics * hla-matched related or unrelated donor available (in case of high-risk disease) * age 18 to 60 * informed consent * consent of donor to donate peripheral blood stem cells * sufficient liver function (elevation of transferases \< 2.5 x upper limit) exclusion criteria: * aml with t(5;17) * aml with t((8;21) * clinically relevant heart failure (nyha ii-iv) * renal failure (creatinine \> 200 µg/ml) * liver function failure (bilirubin \> 3 mg/dl) * concomitant neurological or psychiatric disease * contraindications to receive prescribed study medication * hiv infection * pregnancy

Keywords: reduced-intensity conditioning fludarabine acute myeloid leukemia treatment-related mortality
a study to test bioequivalence between one test formulation of ibuprofen and two reference treatments

Conditions: Pain

Summary: this study is designed to assess bioequivalence between one test and two reference formulations used for treatment of headaches and temporary relief of pain.

the study is a single dose, randomized, three-way crossover study in 30 healthy subjects, with equal numbers of males and females (minimum of 13 of either gender). drop-outs will not be replaced. the three doses of medication given in the study (a single dose in each of the three study periods) will each be separated by a washout period of at least 7 calendar days. in each study period, eighteen (18) blood samples for pharmacokinetic analysis will be taken over 12 hours. blood samples will be centrifuged and concentrations of ibuprofen (r-enantiomer and s-enantiomer) in plasma will be measured using a validated chromatographic assay. pharmacokinetic parameters will be calculated from plasma concentration data \[r-enantiomer, s-enantiomer and total (sum of both enantiomers)\]. the rate and extent of absorption of the formulations will be compared.

Eligibility criteria:
inclusion criteria: * male or female subjects (equal numbers of males and females) * volunteers aged of at least 18 years but not older than 55 years * subjects will have a body mass index (bmi) greater than or equal to 18.5 and below 30 kg/m2; and a total body weight \>50 kg * non- or ex-smokers; an ex-smoker being defined as someone who completely stopped smoking for at least 12 months before day 1 of this study. * clinical laboratory values within the laboratory's stated normal range; if not within this range, they must be without any clinical significance * have no clinically significant diseases captured in the medical history or evidence of clinically significant findings on physical examination and/or clinical laboratory evaluations (hematology, biochemistry, ecg and urinalysis) * has signed and dated the informed consent document, indicating that the subject has been informed of all pertinent aspects of the study * willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures exclusion criteria: * seated pulse rate below 45 bpm or higher than 90 bpm at screening * seated blood pressure below 90/60 mmhg or higher than 140/90 mmhg at screening * relationship to persons involved directly with the conduct of the study (i.e., principal investigator; sub-investigators; study coordinators; other study personnel; employees or contractors of the sponsor or johnson \& johnson subsidiaries; and the families of each) * presence of any tongue piercings * presence of braces * females who are pregnant or are lactating * females of childbearing potential or males with a female partner of childbearing potential who refuse to use an acceptable contraceptive regimen throughout the entire duration of the study * females who are pregnant according to a positive serum pregnancy test * any medical history or condition, or use of any drug or medication, that the investigator determines could compromise subject safety or the evaluation of results.
transconjunctival vs transcutaneous anaesthesia in oculoplastics

Conditions: Anesthesia, Local; Eyelid Diseases

Summary: eyelid surgery is commonly performed under local anaesthesia. for many such procedures, the local anaesthetic injection may be given either transcutaneously (through the skin) or transconjunctivally (through the conjunctiva, i.e. from the inner surface of the eyelid after administration of topical anaesthetic drops). both methods are commonly used, sometimes in combination. currently, the choice of route is largely determined by surgeon preference, but it is not known whether one method is better or more comfortable than the other. our study will compare the two methods of local anaesthetic administration, in terms of patient comfort during anaesthetic administration, efficacy (i.e. whether any additional anaesthetic is needed during surgery), and adverse effects (e.g. bruising, postoperative double vision). we will recruit adult patients who are due to undergo eyelid surgery on both sides under local anaesthesia, on miss siah's lists at southampton general hospital or lymington hospital. patients will receive topical anaesthetic eye drops to both eyes, followed by an injection of local anaesthetic to each eyelid. one side will be administered transcutaneously, and the other side transconjunctivally. the order be randomised. after the injections, participants will be asked to rate their pain levels during each injection on a standardised numerical scale (1-10). a photograph will also be taken, so that an independent assessor can subsequently rate the extent of any bruising. the eyelid surgery will then be performed as normal, with any need for further anaesthetic during the surgery being recorded. patients will attend for their normal follow-up appointment afterwards and any postoperative complications will be recorded, but the study will not require any extra hospital visits. the study is sponsored by university hospitals nhs foundation trust, but does not have any external funding.


Eligibility criteria:
inclusion criteria: * patients undergoing bilateral oculoplastic procedures under local anaesthesia on selected lists at southampton general hospital or lymington new forest hospital, uk * able to give informed consent and adhere to the study protocol exclusion criteria: * patients undergoing substantially different procedures on each eye * patients undergoing procedures not amenable to the administration of anaesthetic via the transconjunctival route (e.g. brow lift) * patients undergoing a first procedure on one eye and a 'redo' procedure on the fellow eye (as the presence of scar tissue on the previously operated eye is likely to affect results) * patients having their procedure under general anaesthesia, or receiving intravenous sedation prior to the administration of local anaesthetic

Keywords: oculoplastic surgery
rapid detection of airway pathogens for lung transplantation

Conditions: Lung Transplantation; Respiratory Tract Infections; Pulmonary Infection

Summary: pneumonias and lower respiratory tract infections can have important long-term consequences, particularly in the context of lung transplantation, where pneumonia is a major cause of death. candidate organs and lung transplant recipients undergo bronchoscopic inspection to assess for lower respiratory tract infection, but traditional culture methods take time, leading to increased risk from inappropriate therapy. the investigators hypothesize that the rapid detection of lower respiratory tract infection, using a semi-quantitative multiplex molecular assay, can decrease the time to appropriate clinical decision making.

before and after lung transplantation, clinical decision-making for infection diagnosis can be delayed by the time requirements of traditional culture techniques. this study will enroll lung transplant donor candidates and recipients undergoing assessment for lower respiratory tract infection by bronchoscopic alveolar lavage (or washing). the investigators will record bronchoscopy time and time to test result and clinical management decision based on traditional culture methods. the investigators will perform a semi-quantitative multiplex molecular assay for lower respiratory tract infection using the biofire pneumonia panel and these results will be evaluated by clinicians not directly involved in patient care. timing and outcome of clinical decision making will be recorded. the investigators will compare the time to result using a paired student's t-test between traditional and molecular methods. secondary endpoints include time to clinical decision, postulated changes in clinical decisions, and agreement between methods.

Eligibility criteria:
inclusion criteria: * subjects will be included if subjects are able and willing to provide informed consent for this study as part of an ongoing prospective biorepository and clinical data repository cohort study. * donors can be included as subjects if families provide informed consent. exclusion criteria: * samples from donor organs will be excluded if the organs are unlikely likely to be used based on review of preliminary data. * post-transplant samples will be excluded if the suspicion for infection is sufficiently low that lavage samples are not sent for microbiologic workup or there is insufficient sample for research.
functioning in individuals with cervical radiculopathy after posterior cervical decompression

Conditions: Cervical Radiculopathy

Summary: compression on structures, as spinal nerves, in the cervical spine can cause cervical radiculopathy which leads to pain, disability, and reduced quality of life for the affected individual. cervical foraminotomy with our without laminectomy are common posterior decompression surgical techniques for treating cervical radiculopathy. there is a lack of knowledge regarding function in patients with cervical radiculopathy after posterior cervical decompression. the aim with this study is to study pain, function, psychosocial factors, and health related quality of life after posterior cervical decompression in patients with cervical radiculopathy. this is a prospective multicenter longitudinal observational cohort study with follow-up at three, 12- and 24 months postoperative. a total of 154 individuals scheduled to undergo foraminotomy with our without laminectomy due to cervical radiculopathy will be included. primary outcome is neck-specific function measured with the neck disability index. data will be collected preoperatively and at three, 12 and 24 months with electronic questionnaire.


Eligibility criteria:
inclusion criteria: * cervical radiculopathy, confirmed by mri images (or alternative neuroradiological imaging if mri contraindicated) compatible with clinical findings of nerve root compression (neurological examination performed by a neurosurgeon/orthopedic surgeon) * posterior cervical decompression as foraminotomy with our without laminectomy * at least 3 months of persistent arm pain * age 18-75 years exclusion criteria: * nurick score 2 or more (to exclude individuals with moderate to high myelopathy) * previous surgery of cervical spine * previous fracture or dislocation of the cervical spine * malignancy or benign spinal tumor (eg, neuromas) * spinal infection * previous spondylodiscitis * servere mental disorder * known alcohol or drug abuse * lack of ability to write/comprehend/express oneself in swedish
environmental pollutants and the risk of soft tissue sarcoma: a pilot study

Conditions: Soft Tissue Sarcoma

Summary: the purpose of this study is to assess the feasibility of conducting a large hospital based case control study of the role of dioxins and dioxinlike polychlorinated dibenzofurans (pcdfs) and polychlorinated biphenyls (pcbs).


Eligibility criteria:
inclusion criteria: * patients with soft tissue sarcoma at mskcc are eligible for this study if they meet the following criteria: * between 18 and 79 years of age * were diagnosed within the previous 6 months with primary soft tissue sarcoma of one of the following histologic subtypes: liposarcoma, leiomyoscaroma, mfh, or synovial sarcoma * are enrolled in protocol 02-060 ("novel biochemical and molecularr determinants for soft tissue sarcoma"; pi, dr. samuel singer) * controls will be eligibile for this study if they meet the following criteria * are b/w 18-79 years of age * have no prior history of cancer (other than non melanoma skin cancer) exclusion criteria: * individuals will be excluded if they * are unable to sign informed consent for medical or other reasons * do not speak english

Keywords: soft tissue sarcoma environment pollutants 04-088
donor breast milk and serum ferritin levels in very preterm infants

Conditions: Ferritin Levels in Very Preterm Infants

Summary: this study compares the iron levels in very preterm infants receiving donor breast (dbm) milk to very preterm infants receiving maternal breast milk (mbm).


Eligibility criteria:
inclusion criteria: 1. all preterm infants born between 29 weeks and 0 days -32 weeks and 6 days of gestational age and admitted to the nicu at advent health for children 2. received either mbm or dbm starting between 5 to10 days of life a. infants receiving \>50% feeding volume by dbm for the first 14 days of life will be considered to have received predominantly dbm. the comparison group will be infants who received \> 50% of mbm for the first 14 days of life. 3. parent able to read and write in the english language. exclusion criteria: 1. death prior to completion of participation 2. extremis with likelihood of death prior to completion of participation in the study 3. blood transfusion as determined by clinical team during the study 4. major congenital anomaly or genetic syndrome and 5. major surgical gi conditions that preclude feeding

Keywords: breast milk donor breast milk ferritin level very preterm infants
general anesthesia versus sedation by dexmedetomidine and ketamine with local infiltration for percutaneous transcatheter closure of atrial septal defect in pediatric patients

Conditions: General Anesthesia; Dexmedetomidine; Ketamine; Local Infiltration; Atrial Septal Defect

Summary: the aim of the present study is to compare between general anesthesia versus sedation with dexmedetomidine and ketamine with local infilteration at the catheter insertion site in pediatric patients undergoing transcutaneous closure of atrial septal defect on hemodynamic changes.

atrial septal defect (asd) is one of the most common types of congenital heart defects, occurring in about 25% of children general anaesthesia is usually obtained with tracheal intubation and mechanical ventilation or spontaneous breathing, the depth of anesthesia required to tolerate the presence of a tracheal tube will invariably lead to some reduction in myocardial contractility and alteration of respiratory mechanics. the goal of anesthetic technique is to provide sedation and analgesia during cardiac catheterization to ensure immobility and hemodynamic stability. ketamine is an n-methyl-d-aspartate receptor (nmda) antagonist with sedative, analgesic, and sympathomimetic effects. among its benefits ,it has the ability to protect airway reflexes with minimal effect on ventilatory drive. dexmedetomidine is a highly selective alpha-2 adrenoreceptor agonist with sedative, anxiolytic, and analgesic effect, it also blunts the sympathetic nervous system response to surgical stimulation.

Eligibility criteria:
inclusion criteria: * aged 3-8 years old. * both genders. * american society of anesthesiologists (asa) physical status ii-iii * pediatric patients scheduled for elective transcatheter atrial septal defect closure. exclusion criteria: * patients with multiple congenital anomalies. * patients with congestive heart failure * patients with organ dysfunction liver or renal disease or pulmonary disease. * recent chest infection. * airway abnormalities.
evaluation of bone changes around implants in patients treated with all on four

Conditions: Edentulous Alveolar Ridge In Mandible; Complete Edentulism; All on Four Technique; Dental Implant; Edentulous Jaws; Edentulous Mouth

Summary: the goal of the clinical trail is to evaluate the bone height changes around two axially placed anterior implants and two distally inclined 30-degree angle posterior implants in comparison to two axially placed anterior implants and two distally inclined 45-degree angle posterior implants using cone beam ct (cbct). patients will visit the clinic after the surgery and after the framework and denture insertion for check ups and during the follow up periods ( at denture insertion, 6 months and 12 months)

all patients will receive upper complete dentures and mandibular all on-4 screw-retained prosthesis. the upper complete denture will be mucosa supported and the lower will be all on-4 screw-retained prosthesis. patients will be divided into two equal groups; group i will receive two axially placed anterior implants and two distally inclined 30-degree angle posterior implants, while group ii will receive two axially placed anterior implants and two distally inclined 45-degree angle posterior implants. both groups will be functionally loaded after three months of insertion. bone height changes around axial and distally inclined implants will be evaluated using cone beam ct (cbct), all records will be taken at time of denture insertion, 6 and 12 months later.

Eligibility criteria:
inclusion criteria: * all patients' ages must range from 50-65 years old. * all patients' ridges should be covered with firm mucosa free from any signs of inflammation or ulceration and exhibit adequate height and width of the residual alveolar ridge. * patients should be free from any metabolic or bone disorders that contraindicate implant installation. * all patients must have sufficient inter arch space exclusion criteria: * patients with oral or systemic diseases. * patients with xerostomia or excessive salivation. * patients with parafunctional habits (bruxism or clenching). * heavy smoker or alcoholic patients. * patients with history of temporo-mandibular dysfunction. * patients with brain disorders or psychiatric disorders

Keywords: completely edentulous patients dental implants all on four technique fixed detachable prosthesis screw retained prosthesis
infection after free fibula flap reconstruction of the mandible: a retrospective cohort study

Conditions: Bone and Joint Infection

Summary: mandibular osteitis after flap reconstruction is rare but is a serious infection with significant sequelae. the aim of this study is to describe this type of infection


Eligibility criteria:
inclusion criteria: * patients having had infection after a free bony flap reconstruction of the mandibule treated as an osteomyelitis at the crioac between 2014 and 2020 exclusion criteria: * non-bony flap

Keywords: mandibular flap