Kornimate/medical-research-clean huggingface dataset:
pronation during veno-venous extra corporeal membrane oxygenation

Conditions: Acute Respiratory Distress Syndrome; Acute Respiratory Failure

Summary: the acute respiratory distress syndrome (ards) is defined by a recent (within 1 week) respiratory failure, not fully explained by cardiac failure or fluid overload. ards is also characterized by bilateral opacities at the chest imaging, with an alteration of the oxygenation while positive end-expiratory pressure equal or greater than 5 cmh2o is applied. severe ards is characterized by a high mortality. in the most severe ards patients, venovenous extracorporeal membrane oxygenation (vv-ecmo) is increasingly accepted as a mean to support vital function, although not free from complications. in patients with severe ards, prone position has been used for many years to improve oxygenation. in these patients, early application of prolonged (16 hours) prone-positioning sessions significantly decreased 28-day and 90-day mortality. more recently, prone position and ecmo have been coupled as concurrent treatment. indeed, the addition of prone positioning therapy concurrently with ecmo can aid in optimizing alveolar recruitment, and reducing ventilator-induced lung injury. nowadays, few data exist on respiratory mechanics modifications before and after the application of prone position in patients with severe ards receiving vv-ecmo. the investigators have therefore designed this observational study to assess the modifications of mechanical properties of the respiratory system, ventilation and aeration distribution, and hemodynamics occurring during ecmo before and after prone position in patients with severe ards.


Eligibility criteria:
inclusion criteria: * all adult patients with a diagnosis of severe acute respiratory distress syndrome receiving veno-venous ecmo exclusion criteria: * mechanical ventilation for 7 days or longer * pregnancy * body mass index (bmi) \> 45 kg/m2 * chronic respiratory failure with long-term oxygen therapy or domiciliary non-invasive ventilation * cardiac failure resulting in veno-arterial ecmo * history of heparin- induced thrombocytopenia * cancer with a life expectancy of less than 5 years * moribund condition or a simplified acute physiology score (saps-ii) value of more than 90; * current non drug- induced coma after cardiac arrest or presence of an irreversible neurologic injury * decision to withhold or withdraw life--sustaining therapies * presence of pneumothorax and/or pulmonary emphysema * recent (1 week) thoracic surgery * presence of chest burns * inclusion in other research protocols * refusal of consent.

Keywords: extra corporeal membrane oxygenation prone position
videolaryngoscopy during cpr for trauma patients

Conditions: Cardiopulmonary Arrest; Neck Injury Multiple

Summary: this is a clinical study based on collected video-clip data of cardiopulmonary resuscitation for patients with suspected neck injury in multiple trauma between 2011 and 2015. the study aimed to compare all possible factors relating to eti performance during cpr for truma patients between experienced video-laryngoscopy and direct- laryngoscopy users.

endotracheal intubation (eti) is considered to be the best method of airway management during cardiopulmonary resuscitation (cpr). however eti during cpr is a highly skill-dependent procedure, then it should be attempted only highly trained physicians. especially, cervical immobilization by neck collar in truamatic patients is a great obstacle to successful eti during cpr. because of technical difficulty in using direct laryngoscopy (dl), various types of videolaryngoscopy (vl) devices have been developed to overcome the problems of dl. vl may be more useful to perform eti during cpr for trauma patients with cervical immobilization. this study tried to compare the success rate of endotracheal intubation (eti), speed of eti, incidence of complications, and chest compression interruptions during cardiopulmonary resuscitation for trauma patients with suspected neck injury between intubators using the dl and the vl in a real clinical setting.

Eligibility criteria:
inclusion criteria: * multiple trauma patients with suspected neck injuries * arrest patients exclusion criteria: * case of requesting the do-not attempt resuscitation before eti * already intubated case before arrival to hospital * cardiac arrest from non-traumatic causes

Keywords: intubation cardiopulmonary resuscitation neck injury
clear aligner versus removable inclined plane in treatment of anterior crossbite

Conditions: Anterior Crossbite

Summary: the study is carried in faculty of dentistry mansoura university to compare the efficiency and health quality life improvement between clear aligner and inclined plane in treatment of anterior crossbite

the study \*include 24 patient each group include 12 patient where randomly allocated and intra-oral scanning is done for them followed by software designing ,printing using petg sheets of 0.75 in aligner group while in inclined plane the appliance is formed in conventional way.

Eligibility criteria:
inclusion criteria:1. patients age (7-12) years. 2. anterior crossbite 3. more than one tooth in a crossbite. 4. favorable oral hygiene 5. no oral habits 6. anb within the normal range i.e. (the crossbite will be diagnosed as functional or dental) - exclusion criteria: 1. systemic conditions that may interfere with the treatment. 2. bad habits that might jeopardize the appliance. 3. transverse discrepancy. 4. previous orthodontic treatment

Keywords: clear aligner , anterior crossbite , inclined plane
inhibitory control adult weight management

Conditions: Overweight and Obesity

Summary: the purpose of this pilot study is to explore the benefits of supplementing the ww (formerly weight watchers) online program with a cognitive training game (polyrules!) among adults with overweight or obesity.

this two-arm pilot study will be used to estimate the effect size in weight loss of supplementing the ww (formerly weight watchers) online program with gamified inhibitory control training (polyrules!) among adults with overweight or obesity. participants ages 18 and older (n=30) will be randomly assigned to one of two study arms: (1) ww (formerly weight watchers) only or (2) ww + gamified inhibitory control training (polyrules!). all participants will complete demographic, medical history questionnaires and cognitive assessment battery at baseline/enrollment and after completing the 3-month intervention protocol. all interactions with polyrules! and ww will be passively recorded to monitor the frequency of interaction with ww and polyrules!.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * read, write and speak english with acceptable visual acuity * bmi between 25-40 kg/m\^2 exclusion criteria: * currently enrolled in weight loss interventions or undergoing bariatric surgery * pregnant women * individuals with severe cognitive delays or visual/hearing impairment
effects of dhea and exercise in the elderly

Conditions: Healthy Volunteers

Summary: dhea or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal galnds. the secretion of hdea declines with aging. dhea is considered a food supplement and it is not regulated by the fda. the purpose of this research is to evaluate ceratin of the biological effects of a reaplcement dose of dhea. as you get older, dhea levels are lower than you were younger. the replamcent dose is the dose of dhea that will raise dhea levesl to the levels found in young people. anotehr purpose is to determine whether dhea enhances the adaptations to an exercise training program.

dhea declines dramatically with age. low dhea levels have been found to correlate with sarcopenia and osteopenia. it is, therefore, postulated that many physiologic changes of aging are secondary to the decline in dhea. thus, the objective of the proposed research is to evaluate the effect of dhea replacement on age-related changes in body composition, muscle function and metabolism, and bone mass in healthy older adults. the specific aims are to evaluate the effects of dhea replacement (50 mg/d) alone, or in combination with resistance exercise training on: a) lean body mass, intraabdominal fat and thigh muscle volume, and muscle protein synthesis rate b) bone mineral density (bmd) of the total body, lumbar spine, and hip and biochemical markers of bone turnover and c) insulin sensitivity. it is hypothesized that dhea administration will have additive or synergistic effects with exercise. healthy but sedentary subjects , aged 65-78 years old, will be randomized to receive either dhea, 50 mg/d, or placebo and to participate in either supervised or home exercise training programs. the supervised exercise program will consist of resistance training designed to increase muscle mass, strength, and bone mass, and decrease fat mass. the goal of this research is to provide information on the potential role of dhea replacement therapy in maintaining the physical health and functional capacity of older people

Eligibility criteria:
inclusion criteria: * 65 to 78 years old men and women exclusion criteria: * hormone therapy, history of hormone-dependent neoplasia, psa above 2.6 ng/ml, or active serious illness, contraindications to exercise, dementia

Keywords: aging, dhea, bone density, muscle mass, insulin action
implementing an integrated rmnch intervention by community health workers in achham and dolakha: national pilot

Conditions: Reproductive, Maternal, Newborn, and Child Health; Integrated, Community-Health Systems

Summary: the investigators will conduct a cluster-controlled, stepped wedge implementation science trial of a bundled reproductive, maternal, neonatal, and child healthcare (rmnch) delivery intervention within an approximate population of 300,000 people in rural nepal. this intervention integrates five evidence-based approaches for reproductive, maternal, newborn, and child health focused on the "golden 1000 days" from conception through age two: 1) community health worker model of home-based care to monitor and increase utilization of services, maternal and neonatal health knowledge, self-efficacy, social support, and emergency planning among mothers; 2) continuous surveillance of all pregnancies and children via an integrated electronic medical record; 3) delivering community-based integrated management of newborn and childhood illness (cb-imnci) via chws; 4) group antenatal and postnatal care to improve care delivery and reduce mortality during the "golden 1000 days" from conception to age two; and 5) balanced counseling to increase post-partum contraception.


Eligibility criteria:
inclusion criteria: 1. reproductive aged women 15-49; 2. reproductive aged women 15-49; recently delivered in past two years; 3. reproductive aged women 15-49; active pregnancy during study period and identified by a chw serving their village 4. children aged 0-2; children of recently-delivered mothers (population #2 or #3 above); 5. healthcare staff; chws serving village clusters, chw leaders serving one of the village clusters, nyaya health nepal and government of nepal employees involved in study design, program implementation, data collection, or data analysis processes; and 6. must reside in either achham or dolakha district, nepal. exclusion criteria: patients meeting inclusion criteria and consenting to study enrollment, as stated above, will be included in the study unless 1) patients migrate from the study are before completion of any of the bundled interventions; 2) patients request exclusion from the study at any point during the bundled intervention.

Keywords: implementation research maternal mortality and morbidity neonatal mortality and morbidity infant mortality and morbidity child mortality and morbidity community health workers health systems strengthening
rosiglitazone and insulin in t1dm adolescents

Conditions: Type 1 Diabetes; Puberty: >Tanner 2 Breast Development or Testis >4ml

Summary: type 1 diabetes is the most common life-long disorder with onset in childhood. patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet. adequate control of blood glucose is essential to prevent long term kidney and eye complications that result in kidney failure and blindness. adolescence is a time when diabetes is difficult to control, due in part to high growth hormone levels causing insulin resistance ( a state where the body does not respond as strongly to insulin). this study will test whether treatment with rosiglitazone (an oral medication used frequently in type 2 diabetes) will reduce the insulin resistance of adolescence and improve the control of type 1 diabetes during puberty.


Eligibility criteria:
inclusion criteria: * t1dm duration \> 1year * age 10-18years * hba1c \> 8% * puberty \> tanner stage 2 breast or testis \>4ml exclusion criteria: * known non-compliance * hypo unaware
temsirolimus versus sorafenib as second-line therapy in patients with advanced rcc who have failed first-line sunitinib

Conditions: Renal Cell Carcinoma

Summary: this is an international, randomized, open-label, outpatient, multicenter study. subjects will be assigned in a 1:1 ratio to 1 of 2 treatment arms: temsirolimus 25 mg once weekly by intravenous (iv) infusion or sorafenib 400 mg by mouth (po) twice daily (bid). these investigational drugs will be administered in 6-week cycles for the duration of the study, up to 24 months. subjects will be stratified by nephrectomy status, duration of response to sunitinib therapy, memorial sloan kettering cancer center (mskcc) prognostic group, and rcc tumor histology.


Eligibility criteria:
inclusion criteria: * histologically confirmed diagnosis of mrcc (regardless of histology or nephrectomy status) with well-documented radiological pd by recist criteria or clinical pd as judged by the investigator while receiving first-line sunitinib therapy. subjects must have at least 1 cycle of sunitinib therapy (minimum of four weeks continuously). * at time of randomization, at least 2 weeks since prior treatment with sunitinib, palliative radiation therapy, and/or surgery. * at time of randomization, there must be at least 1 measurable lesion per recist. lesions that have been previously irradiated or embolized cannot be selected as target lesions. * more criteria apply exclusion criteria: * metastatic cns from rcc. * subjects who discontinued sutent therapy due specifically to intolerance. * prior systemic therapy for mrcc other than sunitinib. * active ketonuria, secondary to poorly controlled diabetes mellitus * more criteria apply

Keywords: metastatic or advanced renal cell carcinoma
screening for early detection and prevention of pompe disease in israel using tandem mass spectrometry

Conditions: Pompe Disease

Summary: the aim of the study is: to develop a comprehensive biochemical assay for detection of pompe disease (glycogen storage disease type ii), to be implemented in the newborn screening program among the israeli population.


Eligibility criteria:
inclusion criteria: * new born babies born during the study period exclusion criteria: * premature babies

Keywords: pompe disease alpha glucosidase newborn screening tandem mass spectrometry (lc-ms-ms) the study aims: to establish the control mean values of alpha glucosidase activity in dry blood spots of newborn babies from israel. to include the alpha glucosidase assay in the newborn screening program in israel
the role of non-alcoholic fatty liver disease in gestational diabetes

Conditions: Gestational Diabetes Mellitus in Pregnancy

Summary: the thought is that non-alcoholic fatty liver disease (nafld) plays a key role in the progression to prediabetes/t2dm in those with a history of gestational diabetes (gdm). the investigators want to know if having a fatty liver will be connected with more glucose abnormalities (higher fasting/oral glucose tolerance test glucose, more insulin resistance) and that a history of gdm will be common in those with nafld.

a liver ultrasound will be completed during the last trimester of pregnancy along with a questionnaire. the questionnaire includes baseline maternal characteristics, age, race, ethnicity, parity, blood pressure, pulse, medications, activity level, sociodemographic and behavioral risk factors, pregravid bmi, previous obstetric history, medical and family history. the subject will come in person to clinic two times after the subject has had her baby (at 6 weeks postpartum, and at 6 months postpartum). the subject will give blood samples during the 6 weeks postpartum visit and 6 months postpartum visit, and an oral glucose tolerance test will be done at these visits. blood samples will be drawn by putting a small needle or iv catheter (a small plastic tube) into a vein in the subject's arm. blood samples will be obtained at timed intervals both before and after the subject is given a glucose beverage to drink, to see how well the subject's body deals with sugar in the blood over time. the total amount of blood to be drawn for each oral glucose tolerance test and research blood work will be approximately 90 ml (about 6 tablespoons). the total volume of blood taken over the course of the study for each subject will be approximately 180 ml (about 12 tablespoons). the subject will have their blood pressure measured with a blood pressure cuff during each clinic visit. the height, weight and pulse rate will also be measured. this will take about five minutes. the subject will have an ultrasound of her liver at the 6 week postpartum visit and 6 month postpartum visit. this will take about 30 to 60 minutes each time. the investigator's study coordinator will call the subject to do a questionnaire over the phone at 3 months after the subject has had the baby. during the phone call, the study coordinator will ask the subject how the baby is being fed. the study coordinator will also update information about development of any new medical problems and medications the subject's doctor might have started, activity levels, and health habits. subjects will be asked questionnaires to update this information during their 6 week postpartum and 6 month postpartum clinic visits as well. the subject's understanding and approval of these procedures is required if she is to participate in this study.

Eligibility criteria:
inclusion criteria: * a pregnant female * age between 18-50 years. exclusion criteria: * pregravid diabetes mellitus * inability to understand and speak english * inability to provide consent * plans to relocate out of the area within 12 months postpartum
platelets for acute wound healing

Conditions: Wounds

Summary: this study will examine whether platelet gel positively affects wound healing. platelet gel will be used to treat punch biopsy wounds and the results will be compared to results from wounds treated with a control treatment.

platelets contribute to the healing process in soft tissue by providing the initial hemostasis that occurs following injury, a framework for fibrin matrix formation and contribution of growth factors. according to the us national institutes of health, surgical procedures are considered a form of controlled injury, so many of the complications faced by surgery patients are very similar to those faced by trauma patients. scientists are currently investigating ways to treat wounds caused by trauma, burns or surgical inventions with biological agents (i.e. growth factors) or new drugs. growth factor priming of acute wound sites pre-activates the cellular and molecular components of tissue repair, prior to tissue injury. objectives are aimed at gathering information to establish evidence that autologous platelet gel positively effects the healing of acute wounds.

Eligibility criteria:
inclusion criteria: * normal volunteers * 18 years old or older exclusion criteria: * pregnant or lactating * diabetic, keloid former, collagen vascular disease * smoker * body mass index \>30kg/m2 * known history of hiv/aids; hepatitis a, b, or c * bleeding disorder * aspirin, non-steroidal anti-inflammatory drug (nsaid) or anticoagulant user * cancer, or treatment for cancer, in past 5 years

Keywords: wounds healing acute wounds healing by secondary intention
study to evaluate the effect of obicetrapib in combination with ezetimibe as an adjunct to his therapy

Conditions: Dyslipidemias; High Cholesterol; Hypercholesterolemia

Summary: this study will be a placebo-controlled, double-blind, randomized, phase 2 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both in combination with ezetimibe 10 mg and as monotherapy, as an adjunct to high-intensity statin therapy.

this study will be a placebo-controlled, double-blind, randomized, phase 2 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both in combination with ezetimibe 10 mg and as monotherapy, as an adjunct to high-intensity statin therapy. the screening period for this study will take up to 2-weeks. afterwards patients will be randomized to placebo, 10 mg obicetrapib monotherapy, or 10 mg obicetrapib + 10 mg ezetimibe combination therapy for a 12-week treatment period. after the treatment period, patients will continue for a 4-week safety follow-up.

Eligibility criteria:
inclusion criteria: * ldl-c \> 70 mg/dl and triglycerides \< 400 mg/dl, * treated with a high-intensity statin therapy exclusion criteria: * bmi \>= 40 kg/m2 * significant cardiovascular disease * hba1c \>= 10% * uncontrolled hypertension * active muscle disease * estimated glomerular filtration rate \< 60 ml/min * hepatic dysfunction * history of participation in any clinical trial evaluating obicetrapib * anemia * history of malignancy * alcohol abuse * treatment with investigational product * treatment with pcsk9 * clinically significant condition * known cetp inhibitor allergy

Keywords: obicetrapib statin ldl-c cholesterol atherosclerosis
laser lithotripsy during urs - holmium vs thulium

Conditions: Urolithiasis

Summary: the aim of the study is to compare urs lithotripsy performed with holmium:yag laser and thulium fiber laser. the study is designed as a prospective clinical randomised trial, where the study participants are randomised to either urs with holmium:yag laser or urs with thulium fiber laser. the outcomes of the urs procedures are compared for the two treatment arms.

the primary aim of the study is to compare the stone free rate (sfr) following urs lithotripsy with holmium and thulium lasers. sfrs will be compared both for ureteral stones, renal stones and ureteral and renal stones in total. secondary aims are to compare the results of the two lasers in terms of operating times, intraoperative complications, postoperative complications and the rate of post endoscopic jj-stenting. the study is designed as a prospective clinical randomised trial, where the study participants are randomised to either urs with holmium:yag laser or urs with thulium fiber laser. the outcomes of the urs procedures are compared for the two treatment arms.

Eligibility criteria:
inclusion criteria: * patients planned for ureteroscopic treatment of ureteral and renal stones at the day surgery unit at haukeland university hospital, bergen, norway exclusion criteria: * known pathology of the upper urinary tract * untreated infection