Kornimate/medical-research-clean huggingface dataset:
feasibility study of neurofeedback training for older adults with mild cognitive impairment

Conditions: Mild Cognitive Impairment, So Stated

Summary: this is a non-pharmacological study evaluating the feasibility of a neurofeedback training program in elderly with mild cognitive impairment (mci) according to recruitment, retention, attendance, acceptability data.

neurofeedback (nf) can be counted amongst promising techniques to improve cognitive functioning if the principles of application are seriously respected, whilst recognizing the necessary adaptation to the conditions of patients with mild cognitive impairment (mci). this study examined the feasibility and acceptability of an electroencephalography neurofeedback training protocol in a sample group of older adults with mci in order to identify the necessary conditions for an improved neurofeedback application. participants performed an electroencephalography recording, a battery of neuropsychological tests before the neurofeedback training program (t0), following the neurofeedback training program (t2) and 1-month follow-up (t3). a questionnaire about motivation, opinions of technical aspects of nf and feeling of cognitive improvement was administered at t0 and t2.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment * absence of history of alcohol or other substance consumption exclusion criteria: * psychiatric and neurological disorders * sensory and/or motor deficit. * involving in another cognitive intervention

Keywords: neurofeedback acceptance technology electroencephalography mci
mri study of blood-brain barrier function in cadasil

Conditions: Cadasil; Blood Brain Barrier Defect

Summary: diffusion prepared pseudo-continuous asl (dp-pcasl) is a newly proposed mri method to noninvasively measure the function of blood-brain barrier (bbb). the investigators aim to investigate whether the water exchange rate across the bbb, estimated with dp-pcasl, is changed in patients with cadasil, and to analyze the association between bbb water exchange rate and mri/clinical features in these patients.

cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil), caused by notch3 gene mutations, is the most frequent monogenic type of hereditary cerebral small vessel disease (csvd). the unique pathophysiological mechanisms that small vessel disorders in cadasil are caused by genetic mutations and that the majority of patients do not combine cerebrovascular disease risk factors make cadasil an ideal model for studying csvd, and the imaging findings on cadasil can be used to diagnose and investigate the etiology of csvd. while abnormalities in the cerebrovascular structure and hemodynamics have been well demonstrated in cadasil, the abnormality of the bbb remains controversial. one dce-mri study suggested an increase in bbb permeability to gadolinium contrast in cadasil, whereas no abnormality of bbb was found in subsequent studies in mouse models and patients. the aim of this study was to assess whether bbb function is abnormal in patients with cadasil using dp-pcasl, which is more sensitive to subtle changes in the bbb compared to dce-mri. the investigators hypothesized that the bbb water exchange rate (kw) is reduced in patients with cadasil compared to controls as assessed by dp-pcasl and that the degree of reduction in bbb water exchange rate correlates with the severity of disease in patients with cadasil.

Eligibility criteria:
inclusion criteria: 1. patients with cadasil confirmed by gene or/and skin biopsy. 2. the age range is 20-70 years old. 3. there is no contraindication to mri examination, and the informed consent is signed. exclusion criteria: 1. combined with definite cerebrovascular disease, or combined with brain tumor, brain trauma and other causes of brain diseases. 2. cadasil is not confirmed. 3. there are contraindications to examination or refusal to sign the informed consent.
feasibility study of a percutaneous mitral valve repair system.

Conditions: Mitral Valve Insufficiency; Mitral Valve Regurgitation; Mitral Valve Incompetence; Mitral Regurgitation; Mitral Insufficiency

Summary: prospective, multi-center, phase i study of the evalve cardiovascular valve repair system (cvrs) in the treatment of mitral valve regurgitation. patients will undergo 30-day, 6 month, 12 month, and 5 year clinical follow-up.

phase i evaluation of the safety and effectiveness of an endovascular approach to the repair of mitral valve regurgitation using the evalve cardiovascular valve repair system. the study is a prospective, multi-center, phase i study of the evalve cardiovascular valve repair system (cvrs) in the treatment of mitral valve regurgitation. a minimum of 20 patients will be enrolled (an additional maximum of 12 roll in-patients, a maximum of 2 per site, may be enrolled and analyzed separately). patients will undergo 30-day, 6 month and 12 month clinical follow-up. up to 12 clinical sites throughout the us may participate. the primary endpoint is acute safety at thirty days, with a secondary efficacy endpoint of reduction of mr.

Eligibility criteria:
inclusion criteria: * have moderate to severe mitral regurgitation, symptomatic or asymptomatic with evidence of left ventricular dysfunction; * experience regurgitation origination from the central two-thirds of the valve; * qualify as a candidate for mitral valve surgery including cardiopulmonary bypass. exclusion criteria: * ejection fraction \< 30% * endocarditis * rheumatic heart disease * renal insufficiency

Keywords: mitral valve insufficiency mitral valve regurgitation mitral valve incompetence mitral regurgitation mitral insufficiency mitral valve mr mitral valve prolapse e2e - edge to edge alfieri technique mitraclip functional mr degenerative mr echocardiogram cad - coronary artery disease heart failure heart attack everest everest i everest ii
periodontal infection and systemic inflammation in renal patients

Conditions: Periodontitis; Chronic Kidney Disease

Summary: the purpose of this study is to examine the role of gum disease in affecting the long term prognosis of renal patients. this disease if untreated causes inflammatory response throughout the body. if the subject has gum disease, he/she will be randomly assigned to one of the two treatment groups. the study investigates what happens to inflammatory markers in blood and saliva after you are treated for gum disease.

the main goal of this project was to explore the contribution of chronic periodontitis to systemic inflammation in chronic kidney disease (ckd). to achieve this goal, the project had two specific objectives: 1. a) to compare the prevalence of periodontal infection between ckd and non-ckd populations and b) to explore the association between the presence of periodontal infection and the uremic status of ckd patients. 2. a) to assess the levels of systemic inflammatory markers, il-6 and crp in the presence or absence of periodontal infection in ckd and b) to compare the serum il-6 and crp levels in response to periodontal intervention.

Eligibility criteria:
inclusion criteria: * dental subjects with periodontitis, * at least 10 teeth * no periodontal (gum) treatment for the last year, * no antibiotic for the last 4 months, * no vascular access infection. exclusion criteria: * smokers
effect of partial sleep deprivation on cognition and cytokines in individuals with major depression

Conditions: Major Depression

Summary: 40 patients with the diagnosis of major depression are included. there are two interventions: partial sleep deprivation (psd) and normal night sleep (ctrl). patients are randomly assigned to psd-(2 undisturbed nights)-ctrl or ctrl-(2 undisturbed nights)-psd. cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.


Eligibility criteria:
inclusion criteria: * major depression * informed consent exclusion criteria: * known epilepsy or previous unexplained loss of consciousness after sleep deprivation * bipolar disorder * acute or chronic inflammatory diseases * psychosis * suicidal tendency * pregnancy or nursing
the microbiome variability and antibiotic resistance of chronic suppurative otitis

Conditions: Suppurative Otitis Media

Summary: ear swabs will be collected from 120 patients with established csom at the ear-nose-throat (ent) outpatient clinic at the ziv medical center, and 120 swabs will be taken from children with otitis media with effusion (ome) undergoing elective tympanostomy tube insertion, serving as a control group. ear swabs will be frozen at -80c until analysis.dna will be purified from ear swabs, and amplified by pcr so that a barcoded 16s rrna library from each subject will be generated. using correlation analysis, we will compare between microbial compositions in chronic otorrhea patients vs. control groups.an additional ear swab will be collected from patients and cultured to test antibiotic resistance.


Eligibility criteria:
inclusion otitis media with effusion,parental informed consent, age between 1 - 9 years, no known immune deficient disorder - exclusion criteria:no parental consent, known immune disorder, current acute otitis media. -
transcranial magnetic stimulation for bipolar depression

Conditions: Bipolar Depression

Summary: this is a study to assess the effectiveness of repetitive transcranial magnetic stimulation (rtms) as a treatment for depressed adults with bipolar disorder. in rtms high-intensity, fluctuating magnetic fields non-invasively stimulate the cortex of the brain depolarising neurons. no anaesthetic is required and the treatment in subconvulsive. recent studies suggest that rtms can be an effective treatment for depressive illness in adults (loo and mitchell et al, 2005) and appears to be quite safe. most of the published studies to date have focused on unipolar depression. there is limited data of tms use in bipolar depression. eg. pilot study by nahas z, kozel fa, li x, anderson b, george ms.in 2003, which was negative. the investigators wish to assess this in a sham-controlled study of adults. the investigators hypothesise that both left and right sided rtms will have an antidepressant effect superior to sham in this population.

inpatients and outpatients with major depressive episodes as part of either bipolar i or ii illness will be eligible. in the event that patients (in any arm) have no significant response after a defined period, they will shift to an open phase where they will receive left prefrontal 10hz stimulation. thus all participants will have the opportunity to receive active treatment.

Eligibility criteria:
inclusion criteria: * dsm-iv major depressive episode of no more than 3 years. * diagnosis of bipolar i or ii disorder * montgomery-asberg depression rating scale score of 20 or more. * aged over 18 * may or may not be taking antidepressant medication. exclusion criteria: * patient not able to give informed consent. * failure to respond to ect in current episode of depression. * significant other axis i psychiatric disorders e.g. schizophrenia. * in imminent physical or psychological danger, or needs rapid clinical response due to inanition, psychosis or high suicide risk. * comorbid substance abuse or dependence * history of neurological illness e.g. epilepsy; neurosurgical procedure * metal in the cranium, a pacemaker, cochlear implant, medication pump or other electronic device. * women of child-bearing age in whom pregnancy cannot be ruled out. * patients with a history of mood 'switching' in response to other treatments.

Keywords: tms treatment bipolar efficacy
gum chewing and postoperative intestinal function after gynecolgic operations

Conditions: Gastrointestinal Disorder Postoperative

Summary: the investigators aimed to assess whether postoperative gum chewing improve intestinal functions.

we will randomize patients into two groups after gynecologic operations. one group will chew gum, the other group not and we will assess the gastrointestinal function functions.

Eligibility criteria:
inclusion criteria: * women underwent gynecologic operation * women who are eligible for gum chewing exclusion criteria: * women with previous gastrointestinal intervantion * women with previous abdominal surgery

Keywords: intestinal function chewing gum
effect of the use of anticoagulant therapy during hospitalization and discharge in patients with covid-19 infection

Conditions: Covid19; Pneumonia; Coagulation Disorder; Pulmonary Embolism

Summary: viral infections provoke the systemic inflammatory response and cause an imbalance between the procoagulant and anticoagulant homeostatic mechanisms. multiple pathogenic mechanisms are involved, including endothelial dysfunction, increased von willebrand factor, toll receptor activation, and tissue factor pathway activation. d-dimer levels greater than 1000 ng / ml are associated with an 18-fold increased risk of mortality. in this context, many patients may require prophylaxis or antithrombotic treatment with low molecular weight heparins. currently, there is no validated scheme on the dose and timing of the use of antithrombotic drugs. the study aims to identify the effect of two anticoagulant strategies (prophylactic and therapeutic) on the progression to ventilatory support or death in patients with covid-19 infection who require hospital care.

randomized clinical trial in patients with a confirmed infection by covid-19 who require hospital treatment and subsequent ambulatory surveillance. study population. patients with a diagnosis by pcr of covid 19, over 18 years of age from the high specialty hospital of ixtapaluca, who meet the inclusion criteria. statistic analysis. the student's t-test was carried out to identify the difference in the means of the quantitative variables between the groups. a value of p ≤ 0.05, 95% ci will be considered significant. for the hypothesis test, the chi-square test will be performed, considering a p≤ 0.05, 95% ci value to be significant.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of covid-19 infection confirmed by polymerase chain reaction test (rq-pcr) requiring hospital care for the administration of supplemental oxygen exclusion criteria: * patients with life expectancy less than 48hrs * patients who require ventilatory support upon admission * age over 75 years or with a history of atrial fibrillation * history of venous or arterial thrombosis * severe neurological impairment * absence of a primary caregiver to supervise the administration of medication * history of cerebral hemorrhage * history of previous use of oral anticoagulants * history of major surgery 30 days prior to admission * uncontrolled systemic arterial hypertension * kdigo stage iii chronic kidney disease or less * hemodialysis or peritoneal dialysis treatment * history of active or inactive cancer * pregnant or postpartum patients

Keywords: covid-19 mortality anticoagulants deep venous thrombosis pulmonary embolism
perturbation based training and bobath-based trunk exercises on gait , postural control and mobility

Conditions: Stroke

Summary: this study compares two approaches for rehabilitating stroke patients: perturbation-based training and bobath-based trunk exercises. the perturbation based training focuses on challenging patients with unexpected movements to improve their balance and stability. while the bobath method, concentrating on facilitating normal movement patterns. the study aims to determine which approach yields better outcomes in terms of trunk control, balance, and functional recovery for stroke patients. this study will also enable the individual to be more independent and minimize their falls.

cerebrovascular is a leading cause of physical impairment and long-term disability in the globe. the complication of stroke is mobility impairment like balance, gait, and posture disorders. this impairment leads to a higher risk of falls, reduced ability in daily activities, and difficulty restoring the overall health and quality of life. cerebrovascular accident is the second cause of fatality. hence, one of the primary objectives in stroke rehabilitation is to restore postural stability and functional balance, which is a combination of dynamic, static and reactive balance. for improving postural stability and balance one such technique is the utilization of a rocker board, where a platform positioned on an unstable surface is used to challenge balance. whilst rocker boards have been used effectively for, postural stability, injury prevention, rehabilitation and balance enhancement. improvements in rocker board performance may be attributable to one or more of the following: muscle strengthening, enhanced intersegmental coordination, increase in brain activity in the supplementary motor area and/or enhanced feed-forward and feed-backward postural control mechanisms.

Eligibility criteria:
inclusion criteria: * able to walk with or without ambulatory aids * able to follow commands. * patients in the subacute and chronic stages associated with stroke hemiparesis (time since * stroke onset 6 months- 1 year) * scoring \> 21 on mmse exclusion criteria: * patients who have severe limitations in passive range of motion at lower extremities * visual and sensory deficits * patient who has contracture * orthopedic or any other neurological disorder which impair balance. * patients undergoing any other balance training protocol. * patients with recurrent strokes * participants who are currently participating in another clinical trial or research study
early identification and predictive parsing for high risk group of schizophrenia

Conditions: High Risk Group of Schizophrenia

Summary: an accurate identification of individuals at ultra-high risk (uhr) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. the diagnostic comparability of several psychometric tools is unknown. to address the psychometric comparability of the caarms, sips and bsabs for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. to verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. all the subjects were assessed for a uhr state by three psychometric tools including caarms, sips and bsabs. the psychometric diagnosis results including at risk of psychosis (uhr+), not at risk of psychosis (uhr-), and psychosis. demographic and clinical characteristics interviewed by these three instruments were also measured. the inter-rater agreement was assessed for evaluation of the coherence of the three scales. transition rates of caarms, sips and bsabs for uch+ subjects within 2 years were also recorded.there is good diagnostic agreement between the caarms, sips and bsabs towards identification of uhr subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.


Eligibility criteria:
inclusion criteria: * all are immediate family and three-generation blood kinship of patients with schizophrenia exclusion criteria: -

Keywords: psychosis; uhr; caarms;sips; bsabs
evaluate safety and biological activity of atyr1940 in participants with limb girdle muscular dystrophy 2b (lgmd2b) and facioscapulohumeral muscular dystrophy (fshd)

Conditions: Limb-Girdle Muscular Dystrophies; Facioscapulohumeral Muscular Dystrophy

Summary: the purpose of this study is to assess the safety and biological activity of atyr1940 in participants with lgmd2b and fshd.


Eligibility criteria:
inclusion criteria: * provided informed consent. * investigator's opinion, participant is willing and able to complete all study procedures and comply with the study visit schedule. participant with lgmd2b: * established, genetically confirmed diagnosis of lgmd2b. * either the presence of a short tau inversion recovery (stir) positive muscle on lower extremity skeletal muscle magnetic resonance imaging (mri), or, if no stir positive muscles, meets muscle biomarker criteria. participant with fshd: * established, genetically confirmed diagnosis of fshd. * the presence of a stir positive muscle on lower extremity skeletal muscle mri. exclusion criteria: * currently receiving treatment with an immunomodulatory agent, including targeted biological therapies within the 3 months before baseline; corticosteroids within 3 months before baseline; or high-dose non-steroidal anti-inflammatory agents within 2 weeks before baseline. * currently receiving curcumin or albuterol; use of a product that putatively enhances muscle growth on a chronic basis within 30 days before baseline; statin treatment initiation or significant adjustment to statin regimen within 3 months before baseline (stable, chronic statin use is permissible). * use of an investigational product or device within 30 days before baseline. * evidence of an alternative diagnosis other than lgmd2b or fshd or a coexisting myopathy or dystrophy, based on prior muscle biopsy or other available investigations. * history of severe restrictive or obstructive lung disease or evidence for interstitial lung disease on screening chest radiograph. * history of anti-synthetase syndrome, prior jo-1 ab-positivity, or a positive or equivocally positive jo-1 ab test result during screening. * chronic infection, such as hepatitis b, hepatitis c, or human immunodeficiency virus or a history of tuberculosis. * vaccination within 8 weeks before baseline or vaccination is planned during study participation. * symptomatic cardiomyopathy or severe cardiac arrhythmia that may in the investigator's opinion, limit the participant's ability to complete the study protocol. * muscle biopsy within 30 days before baseline.

Keywords: lgmd2b fshd
sleep, diabetic retinopathy and melatonin

Conditions: Diabetes Mellitus; Diabetic Retinopathy

Summary: this study explores the use of melatonin in patients with diabetic retinopathy

this is a randomized controlled study using melatonin for 8 weeks in patients with diabetic retinopathy on outcomes of sleep and circadian regulation

Eligibility criteria:
inclusion criteria: * type 2 diabetes (clinically diagnosed, taking anti-diabetes medications or history of elevated a1c≥6.5%) * 40-65 years of age * diabetic retinopathy of at least moderate degree exclusion criteria: * use of melatonin * antidepressants or antipsychotics * illicit drug use * night shift work or travel beyond 2 time zones in the month before enrollment * end stage renal disease requiring renal replacement therapy * history of stroke or transient ischemic attacks * history of dementia or memory impairment * uncontrolled congestive heart failure or recent hospitalization for cardiac condition (6 months) * chronic obstructive pulmonary disease requiring oxygen * severe chronic liver disease such as cirrhosis * ongoing treatment for major medical problems such as cancer * history of severe hypoglycemia defined as hypoglycemic episodes requiring assistance from others within the past six months. * significant depressive symptoms * untreated severe osa (ahi≥ 30 events/hour), * uncontrolled hypertension (blood pressure ≥ 160/100 mmhg), * uncontrolled diabetes (a1c ≥ 11%), * abnormal tsh * abnormal liver function (ast or alt\>3x upper limits of normal * use of sedatives and hypnotics. * clinically significant epiretinal membranes, clinically significant lens opacities, or cystoid macular edema, iris neovascularization, iris atrophy, or an asymmetrically shaped pupil, nuclear sclerotic, posterior subcapsular, or cortical lens opacities greater than 2+, a history of pan-retinal photocoagulation. * hemoglobin \<11.5 g/dl in women and \<13.5 g/dl in men.