Kornimate/medical-research-clean huggingface dataset:
etrasimod versus placebo for the treatment of moderately active ulcerative colitis

Conditions: Ulcerative Colitis

Summary: the purpose of this study is to determine whether oral etrasimod is a safe and effective treatment for moderately active ulcerative colitis in adult participants.


Eligibility criteria:
inclusion criteria: * diagnosed with ulcerative colitis (uc) ≥ 3 months prior to screening * active uc confirmed by endoscopy * moderately active uc defined as a modified mayo score of 4 to 6 and an endoscopic score ≥ 2 and rectal bleeding score ≥ 1 * received a surveillance colonoscopy within 12 months before baseline exclusion criteria: * severe extensive colitis * diagnosis of crohn's disease or indeterminate colitis or the presence or history of a fistula consistent with crohn's disease * diagnosis of microscopic colitis, ischemic colitis, or infectious colitis * hospitalization for exacerbation of uc requiring intravenous steroids within 12 weeks prior to or after screening

Keywords: ulcerative colitis etrasimod apd334 uc
effect of a sciatic block (snb) combined with a continuous femoral block (cfnb) on pain scores after knee arthroplasty

Conditions: Postoperative Pain

Summary: the purpose of this study is to determine if the addition of a sciatic nerve block (snb) to a continuous femoral nerve block (cfnb) improves post-operative analgesia after knee arthroplasty.

background: postoperative pain after total knee replacement /arthroplasty (tka) is a major concern. it is severe pain in 60% of patients and moderate in 30%. continuous femoral nerve blocks (cfnb) are considered an excellent choice for regional anesthesia for major knee repair but there are some controversies about the need of supplemental obturator or sciatic nerve blocks for achieving better postoperative analgesia. a recent meta-analysis states there is no sufficient evidence to recommend or discharge these associations. objectives: we aim to assess the efficacy of the association of a sciatic nerve block (snb) and a continuous femoral nerve block (cfnb) for reducing postoperative pain in patients submitted to tka. methods: a randomized controlled study on 50 patients submitted to tka. control group receives a femoral nerve block with a catheter before general anesthesia is induced and the intervention group gets a similar block plus a single shot snb before general anesthesia. both groups start a continuous local anesthetic infusion through femoral catheter after the end of surgery and supplemental oral diclofenac and paracetamol. pain scores are measured until 24h postoperatively, side effects and patient satisfaction are monitored.

Eligibility criteria:
inclusion criteria: * unilateral total knee replacement exclusion criteria: * contra-indication for general anesthesia * infection on puncture site * coagulation disorders * pre-existent neuropathies * allergies to local anesthetics, paracetamol, diclofenac and tramadol * severe dyspepsia * less than 50kg weigh * body mass index (bmi) greater than 40 * american society of anesthesiologists (asa) physical status 4 or 5 * absence of capacity to use the visual analog score (vas) scale * refusal to give informed consent

Keywords: postoperative pain knee arthroplasty peripheral nerve blocks sciatic nerve block femoral nerve block
helpfulness of the vibration test performed in room light on clients with inner ear problems

Conditions: Vestibular Disease

Summary: the purpose of this study is to explore the diagnostic values associated with both a positive and negative skull vibration induced nystagmus test (svint) performed in room light (with fixation). the hypotheses include: 1. a positive room light svint will be identified in individuals with moderate to severe vestibular asymmetries. 2. a positive room light svint will be present when 10 beats or more (counted over 10 seconds) of nystagmus are found with fixation blocked.

dizziness and vertigo account for about four million visits to the emergency department per year and costs for management in the emergency department are estimated to be about four billion dollars per year. vestibular problems are a major cause of dizziness. simple to perform and inexpensive bedside vestibular tests are needed. the skull vibration-induced nystagmus test (svint) with fixation blocked has been considered a vestibular gold standard test with strong psychometric values. no studies on the diagnostic accuracy of the svint in room light have been performed.

Eligibility criteria:
inclusion criteria: * clients 18 years and older with complaint of dizziness, vertigo, and/or imbalance who are willing to proceed with procedures of study. * inclusion for control group: no history of dizziness, vertigo, and/or imbalance. exclusion criteria: * conditions that warrant immediate referral to the emergency department or primary care physician (undiagnosed and unstable disorders relating to cardiac, neurologic, metabolic, etc, dysfunction); no history of dizziness, vertigo, and/or balance problems. * clients with conditions that therapists believe may be aggravated by testing including, but not limited to: variants of head injuries, migraines, seizure disorders, panic/anxiety, claustrophobia, severe headache and/or nausea, and hypersensitivity to sensory stimuli

Keywords: skull vibration induced nystagmus test mastoid vibration test
efficacy of contingency management in the treatment of adolescents with cannabis use disorders

Conditions: Marijuana Abuse

Summary: cannabis use among spanish adolescents has been increasing in the last decade. it has been related to poor school achievement, delinquency, substance use and psychiatric disorders. furthermore, psychoactive substance use in adolescents presenting psychiatric disorders can result in the development of substance use disorders or the worsening of psychopathology. thus, there's an urge to develop efficient interventions in the treatment of these disorders. therapeutic approaches based on cognitive-behavioural therapy and motivational interviewing have demonstrated a limited efficacy in this population. programs based on contingency management have been reported to be useful both in adult and adolescents, too. but it still remains unclear whether a combination of these therapeutic approaches is feasible and brings a better cost-benefit relation. the investigators' project aims to evaluate the added benefits of supplementing a standard intervention on cannabis use, based on combined approach that includes motivational and cognitive-behavioural elements, with a contingency management program. therefore, pre and post-treatment evaluation will be carried forward in a sample of 30 adolescents (aged 12-18) that initiate treatment for cannabis use related disorder at the child and adolescent psychiatry department of the hospital clinic in barcelona. participants will be randomly assigned to a standard treatment group or an experimental group in which standard treatment will be supplemented with a contingency management protocol. as a secondary objective, a prospective assessment of neuropsychological performance related to cannabis use or abstinence will be carried forward.


Eligibility criteria:
inclusion criteria: * presence of dsm-iv-tr criteria of cannabis abuse and/or dependence * signed informed consent exclusion criteria: * mental retardation * presence of a substance use disorder other than nicotine or cannabis * severe or unstable medical * presence at the moment of inclusion of severe acute psychopathology (acute psychotic symptoms, severe depressive symptoms, suicidal ideation)
assessment of automatic relays by intensive basis advantage compared with manual relays, on the hypotension risks, during noradrenalin administration

Conditions: Hypotension

Summary: circulatory failures are the main cause of admissions in the intensive care unit. it is recommended to prescribe to these patients an intravenous injection of catecholamine to correct this dysfunction and to keep an hemodynamic stability. electric pumps are used to administrate a continuous flow of drugs to patient. when a syringe of drugs ends, it is replaced by a full syringe, it is named "relay". this change may cause a flow interruption and hypotension. in the intensive care unit at departmental hospital (chd) vendee, the manual relays used in common practice will cause hemodynamic instabilities : hypotensions in 20% cases. since 4 years, new devices are also used to make the relays. it is "smart pumps" allowing to manage automated the drug delays. this new method allows to not interrupt the drug flow. it could reduce the occurence of hypotension. a 50% decrease of relative number of hypotension will show that the use of automatic method is the most sure medical strategy. our study want to compare manual and automatic method watching the variations of medium arterial pressure (map) during the fifteen minutes after the relay compared to baseline (map before the relay). noradrenalin is the catecholamine most administrated so we choose to study only the relay for this drug.


Eligibility criteria:
inclusion criteria: * patient \> 18 years, * patient receiving only noradrenalin as catecholamine, * collection of patient's non-objection or his trustworthy person, if appropriate. exclusion criteria: * pregnant or breast feeding patient, * patient receiving an other treatment on the catecholamine way, * no affiliation at a social security, * refusal of patient's trustworthy person or parent, if the patient is unable to give his non-objection. * refusal of patient's participation when he is conscious, * subjects deprived of liberty, under guardianship, hospitalized in a health facility or social or hospitalized without their consent, * patients with secreting tumor, kind pheochromocytoma ou carcinoid tumor.

Keywords: noradrenalin relays automatic relays manual relays hypotension intensive care unit
prandial orientated biphasic insulin aspart 30 therapy - the physiological premix insulin therapy for type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this study is conducted in europe. the aim of this observational study is to document the glycaemic parameters, adverse events, including drug reactions, as well as hypoglycaemic episodes, in patients that switched from insulin glargine combined with oral antidiabetic drugs (oads) to biphasic insulin aspart 30 (novomix® 30) combined with oads, when applicable.


Eligibility criteria:
inclusion criteria: * subjects with diabetes mellitus type 2
effects of inferior mesenteric artery preservation in laparoscopic colorectal resection for diverticular disease.

Conditions: Colonic Diverticuar Disease; Defecatory Functions; Fecal Incontinence; Constipation

Summary: this is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease

this study wants to demonstrate that the preservation of the inferior mesenteric artery allow to improve postoperative defecatory function and improve patient\&#39;s quality of life.

Eligibility criteria:
inclusion criteria: * bmi \&lt; 35 * asa i-iii * hinchey i-iii exclusion criteria: * bmi \&gt; 35 * asa iv * hinchey iv * previous procedures that could have been modified the nervous mesenteric pattern (surgery, radiotherapy or chemotherapy)

Keywords: defecatory function anterior resection syndrome constipation diverticular disease fecal incontinence fragmented evacuation
johns hopkins breast cancer program hormone therapy longitudinal database

Conditions: Breast Cancer

Summary: the purpose of this project is to establish a repository of information and samples from breast cancer patients or those at high risk of developing breast cancer, who are initiating hormone therapy as part of standard clinical care or prevention. this repository will include patient reported outcomes and other questionnaires, information on medication use, data about adherence to the hormone therapy and tumor characteristics, including prospectively collected samples.

this research is being done to learn more about the side effects of breast cancer hormone therapy and if a person's genetic information may help us to develop a way to predict the side effects a patient may have and how best to treat them. in addition, the investigators hope to look at how the side effects from hormone therapy influence a patient's willingness to continue hormonal treatment. men and women being prescribed hormone therapies including tamoxifen, raloxifene (evista), anastrozole (arimidex), letrozole (femara), or exemestane (aromasin), by their oncologist for either prevention of breast cancer or treatment of breast cancer may join. the decision of which hormone therapy to receive is the decision of the patient and physician, this study will collect samples and patient-reported outcomes during this routine, standard of care and will not direct any treatment decisions or interventions in any way.

Eligibility criteria:
inclusion criteria: * male or female * 18 years of age or older * physically and cognitively able to complete the questionnaires * meet one of the following categories: 1) initiating hormonal therapy for breast cancer prevention. all patients planned to initiate hormonal therapy with either tamoxifen, raloxifene (evista®), anastrozole (arimidex®), letrozole (femara®) or exemestane (aromasin®) are eligible; concomitant use of zoladex or lupron is permitted; 2) patients with histologically proven ductal carcinoma in situ (dcis/stage 0) or stage i-iii invasive carcinoma of the breast that is estrogen (er) and/or progesterone (pr) positive by immunohistochemical staining, who are considering one of the above listed serms or ais. these patients must have completed any planned chemotherapy and local therapy (e.g., lumpectomy or mastectomy); however, enrollment/initiation of hormonal therapy on study may be done prior to completion of radiation and/or biologic therapy (e.g., trastuzumab) at the discretion of the treating team; or, 3) the patient is aware of the nature of her diagnosis, understands the study regimen, its requirements, risks, and discomforts, and is able and willing to sign an informed consent form. * patients transitioning from one hormonal agent listed above to another may be enrolled prior to initiation of the new medication. exclusion criteria: * n/a
microbicides acceptability among sexually active young women

Conditions: HIV Infections

Summary: atn 062 is designed to gain scientific knowledge of microbicide-use adherence, acceptability, and attitudes among sexually active young women

atn 062 will take place in parallel to another study, mtn 004, "phase i study of the safety and acceptability of 3% w/w spl7013 gel (vivagel™) applied vaginally in sexually active young women." atn 062 will use quantitative and qualitative research methods. the quantitative method will consist of a computerized diary used by participants during the 14 days of the gel trial of mtn 004. the qualitative methods will include email messages sent by participants to a research assistant as a supplement to the diaries, as well as in-depth interviews through teleconferences to contextualize the recorded events. all study activities will be timed to coincide with those of mtn 004

Eligibility criteria:
inclusion criteria: * currently enrolled in mtn 004. * willing and able to provide written informed consent for atn 062. * willing to participate as required by protocol, including completion of all assessments and follow-ups. exclusion criteria: * refuses to have teleconferences audio recorded. * any social or medical condition that, in the investigator's opinion, would preclude informed consent, make study participation unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives

Keywords: hiv microbicide gel hiv seronegativity
repair of ischemic mitral regurgitation: comparison between flexible and rigid annuloplasty rings

Conditions: Mitral Regurgitation

Summary: mitral valve repair for ischemic mitral regurgitation is performed primarily by annuloplasty. there is some degree of late failure, which may be due in part to the type of ring employed. we want to compare late results with mitral valve annuloplasty using flexible vs rigid annuloplasty rings.


Eligibility criteria:
inclusion criteria: * all patients undergoing cabg with mitral valve repair for ischemic mr exclusion criteria: * other valve procedures

Keywords: ischemic mr annuloplasty
pet scan and ct scan in evaluating response in patients undergoing radiofrequency ablation for lung metastases

Conditions: Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific

Summary: rationale: radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. diagnostic procedures, such as pet scan and ct scan, may help doctors measure the patient's response to treatment. purpose: this clinical trial is studying pet scan and ct scan to see how well they work in evaluating response to treatment in patients undergoing radiofrequency ablation for lung metastases.

objectives: primary * determine the accuracy of positron emission tomography (pet) and ct scan in measuring response at 3 months after radiofrequency ablation (rfa) in patients with lung metastases. secondary * determine the agreement between observers analyzing pet/ct scan results. * determine the outcome of these patients. * determine the false-positive rate and false-negative rate of pet/ct scan at 1 and 3 months in these patients. * determine the optimal time for obtaining a negative pet scan. * determine the sensitivity, specificity, positive predictive value, and negative predictive value of pet/ct scan at 1 and 3 months. * determine the morbidity associated with rfa. * determine the disease-free survival after rfa and the factors predicting recurrent disease in these patients. outline: this is a multicenter study. patients undergo positron emission tomography (pet) and ct scan at baseline. patients then undergo radiofrequency ablation (rfa) for lung metastases. pet/ct scan is repeated at 1 week, 1 month, and 3 months after rfa. after completion of rfa, patients are followed by clinical examination and conventional scanning at 6, 9, and 12 months. projected accrual: a total of 80 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed cancer * radiologically suspected pulmonary metastases * may be confirmed histologically or by specific markers * less than 6 lesions * lesions \< 40 mm * prior positron emission tomography shows 1 hyperfixation (standard uptake variable \> 3) at the level of lesions to be treated * lesions must not be attached to or next to major mediastinal structures * radiofrequency ablation planned as treatment patient characteristics: * life expectancy \> 6 months * no uncontrolled medical condition, including any of the following: * psychiatric condition * infection * coronary insufficiency * new york heart association class iii-iv heart disease * no other serious condition * no contraindication to general anesthesia * not pregnant or nursing prior concurrent therapy: * at least 30 days since prior participation in an investigational study * at least 30 days since prior chemotherapy * no other concurrent investigational agents

Keywords: unspecified adult solid tumor, protocol specific lung metastases
prospective studies of the pathogenesis of schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to use structural and functional magnetic resonance imaging (mri) to study children at high risk for schizophrenia. it is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. the study will also describe normal brain development in children from birth to age 6 years

we are currently following enrolled children at 4 and 6 years of age. we are obtaining structural mris and rsfmris. in addition, we are assessing cognitive function and behavior with stanford-binet, brief and basc.

Eligibility criteria:
inclusion criteria: * control, offspring of mother with schizophrenia or bipolar illness; child with mvm exclusion criteria: * major neurological or medical illness

Keywords: schizophrenia brain development mri
effects of a novel physical exercise program in patients with cirrhosis (the lfn-exercise protocol)

Conditions: Cirrhosis; Portal Hypertension; Exercise

Summary: this study evaluates the effects of a structured exercise (the lfn-exercise protocol) program plus diet, on cerebral hemodynamics (cerebral blood flow) and hepatic hemodynamics (portal pressure), as well as on nutritional status (body composition and nutritional markers) in order to facilitate the prescription of exercise in patients with cirrhosis.


Eligibility criteria:
inclusion criteria: * liver cirrhosis of any aetiology (liver biopsy or a combination of clinical and biochemical variables plus evidence of portal hypertension); without decompensation during the past month; serum creatinine \<1.5 mg/dl; able to attend the appointed visits and willing to participate in the study. exclusion criteria: * presence of high-risk varices in upper endoscopy (red marks, large varices or gastric varices); concomitant cardiopulmonary diseases; decompensated type 2 diabetes mellitus, insulin use or proliferative diabetic retinopathy; orthopaedic or osteomuscular limitations; any type of cancer, primary sclerosing cholangitis and inflammatory bowel disease.
aerobic capacity muscle strength and health related quality of life in children with chronic liver disease

Conditions: Chronic Liver Failure

Summary: physical therapy program for children with chronic liver disease consist of gait training, strengthening ex for ul\&ll, stretching exercise to improve physical fitness and quality of life

intervention study for one group of children diagnosed with chronic liver disease ages more than 6ys, study include assessment and intervention, assessment of 6mwt, grip strength by hand held dynamometer, quadriceps strength by lafayette, al children subjected to laboratory investigation pre and post of study completion, anthropometric measure, quality of life and fatigue assessment then all children will perform physical therapy program of gait training muscle strengthening for 8 week

Eligibility criteria:
inclusion criteria: * their age ranged from7 to14 years old. * residence in cairo to be able to attend the rehabilitation program. * diagnosis of cld as (wilson disease, autoimmune hepatitis, chronic cholestasis , ....etc). * all children were medically stabled * all children had the same socioeconomic status exclusion criteria: * complication that prevent children from performing maximal exercise test as fracture of both upper and lower limbs, cardiovascular instability and muscle disease in patient with glycogen storage disease(gsd) or abnormal creatine phosphokinase(cpk). * patients with cognitive and motor disorders as in case of hepatic encephalopathy and or ascites. * patients who underwent liver transplantation. * patient with end stage liver disease. * history of variceal bleeding from one month ago or less. * no other system disease (chest, cardiac and nervous system). * medical examination no hernia.

Keywords: aerobic capacity chronic liver disease muscle strength