Kornimate/medical-research-clean huggingface dataset:
evaluation on the availability of tongue diagnosis system

Conditions: Tongue Coating Thickness

Summary: the aim of the proposed study is to investigate the agreement between the measurement of the tongue diagnosis system (tds) and the conventional way of tongue diagnosis about the tongue coating thickness (tct) in the tongue diagnosis of the traditional korean medicine (tkm).

tongue diagnosis is one of the important diagnostic techniques to examine the physiologic functions and pathologic changes of the internal organs in tkm. however, traditional tongue diagnosis has inevitable limitations because of the clinician's subjectivity and environmental factors influencing on the diagnostic results. therefore, it is necessary to investigate the availability of the tongue diagnosis system (tds). the aim of the this study is to investigate the agreement between the measurement of tds and the conventional way of tongue diagnosis about tct in the tongue diagnosis of tkm. so, we will assess the agreement between the measurement of tds and the final diagnosis of 5 clinicians with five or more years of clinical experience about tct. additionally, we will evaluate the reproducibility of tds. in the 2nd visit, taking tongue images of each patient with tds will be performed again at 30 minute-intervals in the same way. and then, we will compare the two tds measurements of each patient about tct. after twice examination of tds, the weight of tongue coating (mg) will be measured quantitatively by tongue scraping to analyze the correlation between the weight of tongue coating and the measurements of tds. in addition, after the collection of 60 patients' tongue images is completed, we will ascertain the validity of the five clinicians for diagnosing the tct by assessing the inter-and intra-rater reliability of the five clinicians.

Eligibility criteria:
inclusion criteria: * age 20 years or older * one who meet the rome iii criteria for functional dyspepsia * one who is able to read, write, hear, see something * one who agree on consent form exclusion criteria: * mental disorders * pregnancy * severe systemic organ diseases such as cancer * infectious or other serious consumptive diseases * geographic tongue * one who cannot open his/her mouth or protrude his/her tongue

Keywords: tongue coating thickness tongue diagnosis system tongue coating percentage availability diagnostic device
role of ultrasound imaging in diagnosis of juvenile idiopathic arthritis

Conditions: Juvenile Idiopathic Arthritis

Summary: juvenile idiopathic arthritis (jia) is the most common chronic rheumatic disease of childhood and an important cause of acquired disability in children . despite the heterogeneity, all forms of jia are characterized by prolonged synovial inflammation that can cause cartilage and bone damage, with severe impairment of physical function and impact on the quality of life. the presence of joint involvement in jia may be expressed by ultrasonography findings such as synovial proliferation, effusion, cartilage thinning and bone erosions. us has demonstrated higher sensitivity in detecting synovitis compared to clinical examination msus is commonly regarded as a very useful tool in children, as outlined by the results of recent national and international surveys among pediatric rheumatologists .for most of the respondents, msus owned particular relevance for the ability to detect subclinical synovitis and to improve the classification of patients in jia subtypes, as guidance to intraarticular corticosteroid injections and for capturing early articular damage. in addition, some specific joints were considered as most suited to be studied by msus, specifically the midfoot, the ankle, the hip, the wrist, the small joints of hands and feet. .

juvenile idiopathic arthritis (jia) is the most common chronic rheumatic disease of childhood and an important cause of acquired disability in children . despite the heterogeneity, all forms of jia are characterized by prolonged synovial inflammation that can cause cartilage and bone damage, with severe impairment of physical function and impact on the quality of life. the presence of joint involvement in jia may be expressed by ultrasonography findings such as synovial proliferation, effusion, cartilage thinning and bone erosions. us has demonstrated higher sensitivity in detecting synovitis compared to clinical examination msus is commonly regarded as a very useful tool in children, as outlined by the results of recent national and international surveys among pediatric rheumatologists .for most of the respondents, msus owned particular relevance for the ability to detect subclinical synovitis and to improve the classification of patients in jia subtypes, as guidance to intraarticular corticosteroid injections and for capturing early articular damage. in addition, some specific joints were considered as most suited to be studied by msus, specifically the midfoot, the ankle, the hip, the wrist, the small joints of hands and feet. .

Eligibility criteria:
inclusion criteria: * age between 1-17 years only. * both sexes. * children with any type of juvenile idiopathic arthritis -exclusion criteria * age above 17years. * children with arthritis of known cause.
electroanatomical mapping of patients undergoing catheter ablation procedures using rhythmia mapping system and catheter

Conditions: Cardiac Arrhythmias

Summary: the purpose of this study is a feasibility study for the rhythmia medical mapping system and mapping catheter on patients undergoing catheter ablation procedures for the treatment of cardiac tachyarrhythmias.


Eligibility criteria:
inclusion criteria: 1. patient understands the implications of participating in the study and provides informed consent 2. patient is willing to comply with specified follow-up evaluation and can be contacted by telephone 3. patients referred for a catheter ablation procedure to treat an atrial or ventricular arrhythmia 4. patient can be heparinized during the procedure exclusion criteria: 1. patients requiring an emergency ablation procedure 2. patients hemodynamically unstable 3. patients with nyha class iii or iv heart failure 4. women who are pregnant or lactating 5. patients having cardiac surgery within the past two months 6. patients with long qt syndrome, brugada syndrome, or torsade de pointes 7. patients with intracardiac thrombus, tumor, or other abnormality which precludes catheter introduction 8. patients with acute myocardial infarction within 3 months 9. patients awaiting cardiac transplantation 10. patients enrolled in any other clinical study 11. patients with an age \ 75 years 12. patients with stable/unstable angina or ongoing myocardial ischemia 13. patients with congenital heart disease (not including atrial septal defect (asd) or patent foramen ovale (pfo) without a right to left shunt) where the underlying abnormality increases the risk of an ablative procedure 14. patients with pulmonary hypertension (mean or systolic pulmonary artery (pa) pressure \> 50mm hg on doppler echo) 15. patients with a left atrial diameter \> 55 mm 16. patients with any arrhythmia currently being treated where the arrhythmia or the management may interfere with this study 17. patients with active infection or sepsis 18. patients with untreatable allergy to contrast media 19. patients with a history of blood clotting (bleeding or thrombotic) abnormalities 20. patients with any known sensitivities to heparin or warfarin 21. patients with severe chronic obstructive pulmonary disease (copd) (identified by a forced expiratory volume \[fev1\] \<1) 22. patients with severe co morbidity or poor general physical/mental health that, in the opinion of the investigator, will not allow the patient to be a good study candidate (i.e. other disease processes, mental capacity, substance abuse, shortened life expectance, etc.)
early cardioprotective effect of sevoflurane

Conditions: Coronary Artery Disease; Off Pump Coronary Artery Bypass Surgery

Summary: in vitro studies and in vivo animal experiments have shown that halogenated volatile anesthetics have a protective effect on the ischemic myocardium. in clinical settings however, anesthetic preconditioning may be of more interest. the aim of our study was to evaluate the cardioprotective effect of sevoflurane in patients undergoing off-pump coronary artery bypass surgery. we proposed that a cardioprotective effect of sevoflurane would save myocardial function, which we measured acceleration by esophageal doppler and cardiac index with bolus thermodilution methods, both during brief ischemia and reperfusion.

studies have been performed on human patients undergoing cabg surgery with cardiopulmonary bypass (cpb). only a few studies however have evaluated the effects of volatile anesthetics during coronary artery bypass grafting on a beating heart (opcabg) with conflicting results as far as cardiac biomarker release is concerned. because cpb is known to have a profound impact on cardiac function, studies performed on patients scheduled for opcabg could evaluate more specifically the effects of the anesthetic agents themselves. patients undergoing opcabg have a predictable and predefined ischemic zone during surgery and represent an extremely interesting and safe model for the study of ischemia and cardiac damage in humans. presently, there is still no consensus on the method of administration of volatile anesthetics, including the time to begin administration, its duration, the dosage and selection of volatile anesthetics.

Eligibility criteria:
inclusion criteria: * the degree i or ii of cardiac anesthesia risk evaluation score * angiographically verified coronary artery disease * left ventricular ejection fraction higher than 40% exclusion criteria: * atrioventricular conduction disturbances * previously ventricular arrhythmias requiring antiarrhythmic treatment * atrial fibrillation with rapid ventricular response * myocardial infarction or stroke within 6 months * diabetes mellitus * end-stage of obstructive or restrictive pulmonary disease

Keywords: cardioprotection sevoflurane esophageal doppler thermodilution coronary artery bypass
feasibility study of rapidpulsetm aspiration system as frontline approach for stroke patients

Conditions: Acute Ischemic Stroke

Summary: a feasibility study to evaluate the initial safety and performance of the rapidpulsetm aspiration system in the treatment of patients with acute ischemic stroke (ais) due to large vessel occlusion (lvo).

the purpose of this study is to evaluate the initial safety and performance of the rapidpulse inc. rapidpulsetm aspiration system as frontline approach for use in the treatment of patients with acute ischemic stroke (ais) due to large vessel occlusion (lvo). this is a prospective, multi-center, open label study comparing the safety and performance of the rapidpulsetm aspiration system with non-randomized retrospective controls who otherwise meet the same study inclusion/exclusion criteria. the study will enroll a maximum of 100 participants in the treatment arm and a maximum of 200 participants in the control arm at in up to 10 centers in europe and/or latin america. subjects data will be collected through hospitalization with a 3 months post-procedure study visit.

Eligibility criteria:
key inclusion criteria: * age 18 years or older * clinical diagnosis of acute ischemic stroke with nih stroke scale (nihss) score ≥ 6 with symptom onset (or last seen normal) up to 24 hours * large vessel occlusion in the intracranial internal carotid artery (ica), middle cerebral artery (mca) m1 or m2 segments, basilar or vertebral artery key exclusion criteria: * evidence of hemorrhage * significant mass effect and/or midline shift * vessel tortuosity too difficult to allow endovascular access per investigator judgment * severe or fatal co-morbidities

Keywords: large vessel occlusion mechanical thrombectomy neurovascular intervention
comparison of the effect of a non-immersive vre and ct in patients with tennis elbow

Conditions: Tennis Elbow

Summary: this study investigates the comparative effectiveness of non-immersive virtual reality (vr) therapy and conventional physiotherapy in managing tennis elbow (lateral epicondylitis). tennis elbow is a painful condition often characterized by chronic pain, reduced grip strength, and limited functionality.

conventional treatment approaches, including manual therapy and strengthening exercises, have been widely used but may not fully address the long-term rehabilitation needs of every patient. virtual reality, an emerging tool in rehabilitation, has the potential to enhance patient engagement and adherence by providing an interactive therapeutic environment. participants will be divided into two groups: one receiving vr therapy and the other conventional therapy, with each intervention lasting six weeks. outcome measures include pain intensity (vas), functional disability (dash), patient satisfaction (prtee), grip strength, range of motion (rom), and adherence rates. this study aims to determine if vr therapy can offer superior benefits over conventional

Eligibility criteria:
inclusion criteria: * adults aged 25 to 50 years. * patient diagnosis with lateral epicondylitis. * patients that a medical doctor will be formally diagnosed to have tennis elbow, that is, lateral epicondylitis. * patients who have specific pain and function impairment associated with tennis elbow. * patients giving written consent to participate in the study. willing to participate and provide informed consent. exclusion criteria: * patients with neurological conditions whereby they have abnormal functioning of their arms. * any previous surgical intervention for tennis elbow the presence of other significant musculoskeletal diseases in the upper extremity severe cardiovascular or neurological disorders.
subarachnoid block versus ultrasound guided transversalis fascia plane block for postoperative analgesia of inguinal hernia repair in adults

Conditions: Postoperative Analgesia of Inguinal Hernia Repair in Adults

Summary: the aim of our study is to investigate the effect of the ultrasound guided transversalis fascia plane block on the postoperative opioid consumption as a part of multimodal analgesia in patients undergoing inguinal herniorrhaphy under spinal anesthesia.

the aim of our study is to investigate the efficacy of the ultrasound-guided transversalis fascia plane block as a postoperative analgesia as a part of multimodal analgesia in patients undergoing inguinal herniorrhaphy under spinal anesthesia. the ultrasound (us)-guided transversalis fascia plane (tfp) block was first described by hebbard in 2009. a local anesthetic (la) injected between the transversus abdominis muscle, and its deep investing fascia will block the anterior and the lateral branches of the t12 and l1 nerves (4). the efficacy of this block has been demonstrated in iliac crest bone graft harvesting, caesarean section and inguinal herniorrhaphy

Eligibility criteria:
inclusion criteria: * patients undergoing inguinal herniorrhaphy. * patients 18-60 years. * asa i and ii. * both sexes. * having no contraindication for spinal anesthesia or tfp block. exclusion criteria: * refusal of regional anesthesia. * infection in the back or at the site of injection for tfp block. * inr \> 1.5. * platelet count \< 80000 per microliter of blood. * patients known to be allergic to amide local anesthetics. * bmi greater than 35 kgm_2. * opioid addiction. * have communication problems that may hinder the assessement of pain postoperative.
biological changes in the adipose tissue among pregnant women with diabetes

Conditions: Pregnancy; Diabetes

Summary: the aim of the research is to study the effect of mirna, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. during the study fat tissue, umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a c-section. healthy pregnant women will serve as a control group.

the aim of the research is to study the effect of mirna, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. during the study: 1. fat tissue, umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a c-section. 2. bloods will be analyzed for insulin, c-peptide, glucose and fat profile 3. placenta and fat tissue will be analyzed for mirna and total rna 4. clinical and anthropometric measurements will be taken from the mother 5. placenta status will be taken

Eligibility criteria:
inclusion criteria: * age 18-45 * pregnant * signed consent form * going through an elective c-section * diabetic * reference group: healthy women with no background illness exclusion criteria: * \ 45 * chronic illness that may effect the outcome * polypharmacy
a simple clinical tool to help diagnose pulmonary embolism: phase 1

Conditions: Pulmonary Embolism

Summary: the goal of this project is to determine if the change in oxygen saturation during deep inspiration ("augmented pulse oximetry") can be used as a method to rule out pulmonary embolism (pe). the investigators propose to evaluate a simple, non-invasive clinical tool to help rule out pe. the investigators plan to measure the oxygen saturation of 40 consecutive patients with newly-diagnosed pe (within 60 minutes of diagnosis) and 80 matched controls who do not have a pe. trained, blinded respiratory therapists or study coordinators will record each patient's oxygen saturation before, during, and after a 2-minute period of deep inspirations (vital capacity \[the maximal amount of air that can be inhaled, measured in milliliters\]) using an incentive spirometer. the investigators' central hypothesis is that persons with a pe will not respond to augmented pulse oximetry and will not significantly improve or normalize their oxygen saturation.

patients will be identified and enrolled by the mayo clinic st. marys emergency department staff as they are undergoing medical care in the emergency department. the investigators will calculate the difference in oxygen saturation pre- and post-deep inspiration (δspo2 at 1 minute, 2 minutes and 4 minutes), and then correlate these values with the ct result. in cases of pe, the investigators expect the spo2 to remain unchanged, or to change less than 3-5%. the investigators expect alternate hypoxemic conditions to have a significantly greater increase in spo2.

Eligibility criteria:
inclusion criteria: * 18 years of age or greater. * agrees and able to participate in the study. * room air spo2 (oxygen saturation) less than 92% and newly-diagnosed pe (or controls with no pe) based on ct angiogram result. exclusion criteria: * clinical concern for instability. * systolic blood pressure less than 100 mm hg. * heart rate ≥140 beats per minute. * oxygen saturation less than 85% with more than 4 l supplemental oxygen. * unable to participate/comply with instructions for using the incentive spirometer. * patients from the federal medical center in rochester, minnesota. * patients who do not speak english (due to the need for expediency). patients will be under the care of the emergency department team who have the skills and resources to monitor and treat patients if they were to become unstable.

Keywords: pulmonary embolism pulse oximetry change in oxygen saturation hypoxemia emergency department deep inspiration vital capacity clinical diagnosis
gapp 2 survey: global attitudes of patients and physicians in insulin therapy for type 2 diabetes mellitus

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this study is conducted asia, europe and north america. the aim of this study is to describe insulin therapy adherence and the burden of non-adherence on patient functioning, well-being and diabetes management.


Eligibility criteria:
inclusion criteria: * patients with t2dm: * diagnosed with type 2 diabetes by a healthcare professional * currently being treated with insulin medication, excluding premix insulin treatment * age at least 40 years * diagnosed as having type 2 diabetes over the age of 40 * hcps: * primary care physician, diabetes specialist (diabetologist/endocrinologist) or diabetes specialist nurse/diabetes nurse educator * have a minimum of 2 years experience within current speciality * see a minimum of 20 type 2 diabetes patients per month (40 for diabetes specialists), of which at least 10 per month must be on modern (analogue) inulins
presurgical planning with functional mri (fmri) mapping of motor cortex in patients with cerebral tumors

Conditions: Brain Tumors

Summary: the purpose of this study is to determine if functional mri is precise enough to provide information about the location of brain functions in patients who have brain tumors. this might allow physicians to use a non-invasive procedure to assist with brain mapping prior to surgery

the purpose of this study is to determine if fmri is precise enough to be used in preoperative decision making for patients who have brain tumors. before a patient has brain surgery to have the tumor removed, functional mapping of the brain takes place either intra-operatively or post operatively after a subdural grid implant has been placed. mapping helps the surgeon determine which areas of the brain are responsible for different important body functions. during this mapping procedure the surgeon determines if they can safely remove all or part of a brain tumor. the investigators are hoping to show that fmri is just as accurate in mapping out different areas of the brain, without having to utilize an invasive form of brain mapping.

Eligibility criteria:
inclusion criteria: * all patients with brain tumors and healthy volunteers exclusion criteria: * if patients are pregnant. * if patients suffer from a significant degree of claustrophobia. * if patients are claustrophobic and requires general anesthesia to complete the diagnostic mri. * contraindications for an mri due to surgeries and/or implantation of pacemakers or pacemaker wires, open heart surgery for placement of an artificial heart valve, brain aneurysm surgery, middle ear implants, hearing aids, braces or extensive dental work, cataract surgery or lens implant, any implanted mechanical or electrical device, implanted neurological stimulators or artificial limbs or joints. * contraindications from an mri due to foreign metallic objects in the body such as: bullets, bbs, pellets, surgical magnetic metal clips, joint or bone pins, metal plates, shrapnel or any one who has a history of working near metal who could have metal shavings in their eyes.