Kornimate/medical-research-clean huggingface dataset:
the impact of eswt on healing of fractured mandible

Conditions: Fractured Mandible Due to Trauma

Summary: studying if using extracorporeal radial shockwave therapy as an adjuvant therapy help in accelerating the bone healing and regeneration in mandibular fractures by comparing it with the standard protocol for fractures fixation by plates and screws.

firstly the patient heads to the operating room being placed in a supine position, generally anesthetized by the anesthesiologist. sterilization of intraoral and extraoral sites and draping has been installed. intermaxillary fixation (imf) screws has been inserted in case of there is no arch bar is used. if the arch bar has been used it was inserted before the operation and being cut at the fracture line between the two segments. the transoral or extra-oral approach is utilized to expose the fracture line separating the two segments. fixation of the bony segments with two plates one compression 2.3 plate at the inferior border and tension 2.0 plate five millimeter superiorly to the compression plate. or even one 2.0 plate(champy) then suturing the incision layers with vicryl 3/0. postoperative evaluation with cone beam computed tomography (cbct). these procedures will be done for both groups. the control group with no adjuvant intervention will stop at this point. the other intervention group will be subjected to shockwave by the usage of extracorporeal shockwave device at the third day postoperative. then follow up at the first and fourth month with another cbct to compare the bone healing at the fracture site.

Eligibility criteria:
inclusion criteria: 1 - patients with age ranges from 18-75 years old. 2- patients with fresh mandibular fractures (from zero hour till four or five days). 3- patients free of systemic conditions that might affect or interfere with the healing process of bone segments or rather interfere with carrying out the surgical procedure (thyroid condition, rheumatoid arthritis, uncontrolled diabetes and osteoporosis). exclusion criteria: 1 - patients out of the specified range group 2- patients who went previous operations with infection or malunion. 3- patients with thyroid condition which affects the serum calcium level. 4- patients with systemic conditions that might affect the bone health (osteoarthritis, rheumatoid arthritis, uncontrolled diabetes). 5- patients with heart peacemakers.
changes of gcf levels of rankl and osteoprotegerin in postmenopausal osteoporosis

Conditions: Chronic Periodontitis

Summary: the investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of nuclear factor-kappa b ligand (rankl) and osteoprotegerin (opg) in gingival crevicular fluid (gcf) of patients with osteoporosis under bisphosphonate therapy within 12 months' follow-up. clinical recordings and gcf were obtained from postmenopausal women; with chronic periodontitis and osteoporosis (group a, n=13), with chronic periodontitis and no osteoporosis (group b, n=12), without chronic periodontitis and osteoporosis (group c, n=12), systemically and periodontally healthy controls (group d, n=10) at the baseline. recordings were repeated at the 1st, 6th and 12th months in group a, b and c. rankl and opg values were measured by enzyme-linked immunosorbent assays.

the study groups were selected from postmenopausal patients those referred to department of endocrinology, school of medicine, ondokuz mayis university. bone mineral density (bmd) measurements were performed by dual energy-x-ray absorptiometry from l1-l4 site of lumbar vertebra and/or femur (g/cm2). osteoporosis was defined as t scores less than -2.5 at l1-l4, femur neck or total femur. women with t scores less than -2.5 (groups a and c) were started on bisphosphonate treatment after their initial periodontal examination.

Eligibility criteria:
inclusion criteria: * women with t scores less than -2.5 (groups a and c) * the periodontitis patients were selected based on the radiographical evidence of bone loss, presence of four or more sites with bleeding on probing (bop), ≥5 mm pocket depth (pd) and ≥6 mm clinical attachment loss (cal). * the clinically healthy control groups were selected on the basis of no radiographic bone loss or cal and pd≤3 mm. exclusion criteria: * any known systemic disease rather than osteoporosis * smoking * antibiotic therapy within the last 3 months * periodontal treatment within the last 6 months.

Keywords: bisphosphonate osteoporosis rankl opg periodontitis
study on the diagnosis of ground-glass lung cancer by microwave ablation combined with puncture biopsy

Conditions: Lung Cancer

Summary: this study is a multicenter study. it plans to screen 200 patients with pulmonary nodule lesions with ground glass as the main body, take ct thin-layer scanning 3d reconstruction, apply ai and fragment omics technology to evaluate the risk of malignant transformation of pulmonary nodules, and use microwave ablation to treat pulmonary nodules and combine intraoperative rapid pathology technology to determine the nature of puncture tissue and the degree of ablation, and then explore the optimal ablation time and ablation power.

combining ai and fragmentomics technology, this study enrolled 200 patients with ground-glass lung cancer for comprehensive evaluation. by collecting detailed characteristic data of ground-glass lung cancer, including nodule diameter, average ct value, solid component ratio (ctr), nodule morphology and other related signs, ct imaging and ai technology, and fragmentomics technology were used for comprehensive analysis to form a set of joint strategies to efficiently screen and diagnose patients with early lung cancer. microwave ablation is used to treat lung nodules, and intraoperative rapid pathology technology is used to determine the nature of the punctured tissue and the degree of ablation (observing pathological changes in the lesion area, including cancer cell death and fibrosis of the lesion tissue), determine whether the lesion has been completely ablated, or whether there are residual active cancer cells, and then explore the optimal ablation time and ablation power. finally, long-term follow-up of patients after microwave ablation, including collection of intraoperative/postoperative complication data, regular ct review, evaluation of treatment effect, monitoring for recurrence, and improving individualized treatment plans for patients.

Eligibility criteria:
inclusion criteria: 1. age ≤ 75 years; 2. ggn patients with the maximum axial diameter of the lesion in the lung window ≤ 3 cm; 3. refusing radical surgery or being unable to tolerate surgical treatment; 4. normal coagulation function, platelet count ≥ 60 × 109 /l; 5. ecog score ≤ 2 points; exclusion criteria: 1. patients with the maximum axial diameter of the lesion in the lung window greater than 3 cm 2. platelets \<50×109 /l 3. patients with severe bleeding tendency and coagulation dysfunction that cannot be corrected in the short term 4. severe chronic obstructive pulmonary disease, emphysema, pulmonary fibrosis and pulmonary hypertension 5. patients whose anticoagulant therapy or antiplatelet drugs have been discontinued for less than 5 days before ablation 6. patients with severe heart, liver, kidney and brain dysfunction 7. patients with severe anemia, dehydration and cachexia that cannot be corrected or improved in the short term 8. patients with an estimated survival period of less than 6 months
testing the efficacy and mechanisms of an adapted resilience building intervention in people aging with hiv

Conditions: Resilience; HIV-1-infection; Stress, Psychological

Summary: this study will examine the mechanisms and efficacy of a resilience building intervention in older people living with hiv.

a two-group rct will enroll 100 older (aged 50+) people living with hiv (plhiv), who will be recruited from the uab hiv outpatient clinic. eligible participants will complete a baseline assessment including a 14-day experience sampling method (esm) protocol, and then be randomized to either the intervention group (n=50) or an attention-matched control group (n=50). we will block randomize groups based on race, sex, and self-reported resilience (connor davidson resilience scale). if differences are found between groups on influential variables (e.g., ses), such factors will be controlled in analyses and exploratory aim analyses will examine treatment moderators (e.g., sex, race). both groups will return for four weekly two-hour group visits, followed by a one-month post intervention assessment (including qualitative and quantitative feedback) and a second esm protocol. a three-month follow-up (comparable to baseline) will assess health outcomes. a blinded research assistant will conduct follow-ups. our primary aims will use esm via text messaging, and focus on intervention effects on the use of resilience resources following times when stressors are reported and whether such increases drive improved affective stress reactivity and recovery (aim 1). our secondary aim will examine effects on health outcomes at three months. our exploratory aim will examine moderators of treatment response.

Eligibility criteria:
inclusion criteria: * current uab hiv clinic patient * age 50+ * have a recent history (within the past 12 months) of suboptimal hiv management, defined as having either ≥one record of detectable viral load or ≥one missed clinic visit without prior cancellation/reschedule exclusion criteria: * neurological or severe psychiatric (e.g., schizophrenia, bipolar disorder, major depression) disorders
analgesic efficacy of saphenous nerve block in total knee replacement

Conditions: Post Operative Pain

Summary: we hypothesize that preoperative saphenous nerve block (snb) in combination with periarticular local infiltration provides better post operative pain relief (popr) profile as compared to local infiltration alone

introduction: local infiltration analgesia (lia) is considered acceptable after total knee replacements (tkr) in terms of analgesia, ease of performance, early mobilization and early hospital discharge . continuous femoral nerve block has been used to enhance post op pain relief (popr) for tkr but at the expense of motor blockade . a sub sartorial approach to saphenous nerve block (snb) spares the motor block . to date the role of saphenous nerve block for popr in tkr has not been evaluated. methodology: in order to test this hypothesis, we proposed to carry out a prospective randomized controlled double blinded (surgeon and assessor) trial study. with institutional ethics approval and having obtained written informed consent from each patient, 20 asa 1 - 3 patients scheduled to undergo tkr under spinal anesthesia +/- sedation were allocated to one of two groups i.e. group (snb): patients receiving snb sub sartorial approach and group (nsnb): patients not receiving snb. group allocation was determined using computer generated random number tables. sealed envelopes were opened on the day of the surgery by the attending anesthetist responsible for the care of the recruited patient. postoperative period: patients were then assessed for pain at rest and on movement on arrival in recovery and then at 6 , 12 and 24 hrs. visual analogue scale on a 10 cm straight line was used to assess postoperative pain scores as predictive value of post operative analgesia on rest and movement i.e passive flexion of knee to 30 degree . patients were assessed for any motor block by using maximum tolerable range of active knee flexion (mkf) and maximum range of straight leg raise(mslr) on arrival in recovery and at 6, 12 and 24 hrs. all patients received regular paracetamol 1g 6 hourly, diclofenac 75 mg 12 hourly, oxycontin 10-20 mg ( depending on age) 12 hourly and oxynorm 10 mg as rescue analgesia.

Eligibility criteria:
inclusion criteria: american society of anaesthesia (asa) grade i-lll patients undergoing elective total knee arthroplasty patients able to consent and understand all the components of the study. exclusion criteria: demented patients patients having bilateral knee replacements patients unable to comprehend the use of pain scales allergy to any of the medications used in the study renal dysfunction coagulation disorders peptic ulcer disease precluding use of non-steroidal anti-inflammatory drugs (nsaids) patients unable to use regular opioid medication any chronic pain condition other than osteoarthritis of the knee.

Keywords: total knee replacement bupivacaine levobupivacaine saphenous nerve block local infiltration analgesia
effects of anesthetic methods on hepatic cancer cell malignancy

Conditions: Hepatocellular Carcinoma

Summary: numerous studies found that anesthetic methods can influence the recurrence of tumor and the overall survival of patients after primary cancer surgery. radiofrequency (rf) ablation is now widely used in clinic for treatment of hepatocellular carcinoma (hcc). currently, diverse anesthetic methods, including general anesthesia (ga), epidural anesthesia and local anesthesia (la), are used for rf ablation surgery. using serum from hcc surgery patients randomized to receive either ga or la during surgery, we investigated the effects of anesthetic methods on proliferation, migration and metastasis in hepg2 hepatic cancer cells in vitro.


Eligibility criteria:
inclusion criteria: * patients with a single primary liver tumor of 3cm or smaller, who are scheduled for rf ablation surgery exclusion criteria: * less than 18 or more than 65 years old; * asa physical status 4 or greater; * previous surgery in liver (including radiofrequency ablation); * severe systemic disease (heart, lung, kidney, or immune system); * inr\>1.5 or platelet count \<45,000 cells/mm3; * a history of addiction to opioids; * with known extension beyond the liver; * child-pugh class c.
comparison of efficacy of tranexamic acid mesotherapy versus 0.9% normal saline for melasma

Conditions: Effect of Drugs; Adverse Effects of Medical Drugs

Summary: it is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (ta) by mesotherapy in comparison to normal saline on participants having melasma.

in this prospective single blind split face controlled trial.total 30 patients referred to dermatology ward were selected. at first, patients were examined under wood lamp for determination of melasma type (epidermal, dermal). then, patients underwent tranexamic acid microinjections with a concentration of ta 4 mg/ml with 0.9 % normal saline on their left half of the face and only 0.9%normal saline on their right half of the face, with mesotherapy technique. this procedure was done total of six times with 2-week intervals. participants were assessed by hemi modified melasma area and severity scoring (mmasi) at start and end of the study for each half of face. statistical package for social sciences (spss) , version 23 was used for analysis. p value \< 0.01 was taken significant.

Eligibility criteria:
inclusion criteria: * informed consent * age between 18 to 55 years * bilateral symmetrical mild to severe melasma exclusion criteria: * pregnancy and lactation * history of taken any topical treatment for melasma in previous 1 month * history of bleeding disorders * concomitant use of anticoagulants, * any known drug allergy especially to the study drug, * having associated medical illnesses.

Keywords: melasma tranexamic acid mesotherapy
nebivolol versus carvedilol in patients with heart failure

Conditions: Chronic Heart Failure; Hypertension

Summary: background beta-blockers improve left ventricular (lv) systolic function and prognosis in patients with chronic heart failure. both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (chf), but it is unknown whether their pleiotropic properties may play a role in different subgroups of patients with chf. objective: to compare the effects of nebivolol and carvedilol on lv function and clinical outcome in patients with chronic heart failure and reduced lv systolic function. methods: 160 hypertensive chf patients, lv ejection fraction (ef) 40% and in new york heart association (nyha) functional class ii or iii were randomly assigned to receive carvedilol or nebivolol therapy for 24 months. at baseline and after 24 months of treatment, all patients underwent clinical evaluation: echocardiogram and 6-minute walking test.


Eligibility criteria:
inclusion criteria: * left ventricular ejection fraction (lvef) \< 40%; * symptomatic heart failure with functional new york heart association (nyha) class ii or iii; * arterial hypertension with systolic blood pressure \>140 mmhg and diastolic blood pressure \>85 mmhg; * clinical stability without hospital admission for heart failure in the previous 3 months. exclusion criteria: * history of asthma or severe chronic obstructive pulmonary disease; * severe liver or kidney diseases; * second-degree or third degree heart block without a permanent pacemaker, * sick sinus syndrome, heart rate \<60 beat/min, systolic blood pressure \<90 mmhg.

Keywords: chronic heart failure hypertension beta blockers
treatment of patients with acute sinusitis

Conditions: Acute Bacterial Sinusitis

Summary: for each patient, an initial visit and at least one follow-up visit at the end of treatment should be documented by the treating physician in the case report form.


Eligibility criteria:
inclusion criteria: * any patient with a diagnosis of acute bacterial sinusitis treated with avelox® - in accordance with the local production information. exclusion criteria: * those specified in the local product information - contraindications and precautions must be considered.

Keywords: moxifloxacin mxf avelox sinusitis acute bacterial sinusitis, abs
safety and compliance of taking mesalamine once a day in pediatric patients

Conditions: Ulcerative Colitis

Summary: to determine whether once a day administration of mesalamine is at least as safe and efficacious and administration of multiple doses a day in preventing clinical relapse of ulcerative colitis in children and adolescence.

is taking total dose in mg/kg once a day, as safe as taking total dose divided in mg/kg spreadout during the day in preventing clinical relapse of ulcerative colitis in children and adolescence.

Eligibility criteria:
inclusion criteria: * ages 6 to 18 years, * must be able to swallow tablets, and * biopsy proven ulcerative colitis exclusion criteria: * allergy or hypersensitivity to mesalamine or other salicylates * use of rectal medications

Keywords: mesalamine ulcerative colitis
testosterone and lipolysis, insulin sensitivity and protein metabolism

Conditions: Hypogonadism

Summary: testosterone(t) has known effects on many organ systems, although many of its metabolic actions are unrevealed. t is an anabolic hormone stimulating protein synthesis but this effect has barely been investigated in controlled studies. it also has lipolytic actions influencing body composition, but little is known of its regional impact on fat tissue. t affects insulin sensitivity. there is an increased incidence of hypogonadism in type 2 diabetes, and among patients with hypogonadism there is an increased incidence of type 2 diabetes. the actions of testosterone on glucose metabolism are unknown. the purpose of this study is therefore to: investigate the lipolytic effect of testosterone on muscle and fat tissue. to gain insight in the intracellular mechanisms of testosterone on lipolysis and investigate possible regional differences in lipolysis and changes in body composition. finally to investigate the effect of short term experimental hypogonadism and acute testosterone substitution on cytokines, insulin sensitivity and protein metabolism. the trial is a randomised double blinded cross-over study of 4 x 2 days with an interval of 1 month in between. 12 healthy young men will receive gnrh treatment over a 3 month period and examined on 4 occasions with various degrees of t substitution and placebo . the examinations take place at the research lab within the medical department m. the investigations are deemed relevant to the understanding of the interrelationship between male hypogonadism and type 2 diabetes. the hypothesis is that t has beneficial effects on carbohydrate, fat and protein metabolism. the generated knowledge would therefore hopefully improve prophylaxis, screening and early treatment of both group of patients.


Eligibility criteria:
inclusion criteria: * male, age 20-35 * normal biochemical screen and ecg exclusion criteria: * heart disease * bmi\>25 * diabetes * antecedent or present cancer * vascular disease * antecedent or present hormone treatment * medical treatment with known effects on fat metabolism * big x-ray examinations equivalent to, or more than a chest x-ray and all kinds of ct scans until 6 month before the start of the study and during the study.

Keywords: acute testosterone experimental hypogonadism lipolysis insulin sensitivity protein metabolism experimental hypogonadism testosterone substitution
establishing efficacy of an inpatient intervention and phone app to reduce suicidal risk

Conditions: Suicidal Ideation; Suicide, Attempted

Summary: in this 2-site study, university of texas southwestern medical center (utsw) and western psychiatric institute and clinic (wpic), the investigators will conduct a randomized clinical trial (rct) in 240 psychiatrically hospitalized suicidal adolescents, examining the single and additive effects of two components of an inpatient unit intervention for suicidal adolescents, as safe as possible (asap), which focuses on emotion regulation and safety planning, and an emotion regulation/safety plan phone app (brite).

the investigators aim to randomize 240 adolescents psychiatrically hospitalized for suicidal ideation with a plan or a suicide attempt to one of four treatment arms: (1) asap + brite + tau (treatment as usual); (2) brite + tau (treatment as usual); (3) asap + tau (treatment as usual); and (4) tau (treatment as usual) alone. the investigators will assess suicidal ideation and behavior at 4, 12, and 24 weeks post-intake, in order to: 1. assess the relative efficacy of asap, brite and the combination on suicidal ideation, non-suicidal self-injury (nssi), and suicide attempts, and re-hospitalizations. 2. examine mediators and moderators of treatment outcome. 3. examine the costs and cost efficacy of asap and brite and the combination.

Eligibility criteria:
inclusion criteria: * youth admitted to the inpatient unit at either site for a recent suicide attempt or significant suicidal ideation with a plan or intent. * the youth and parent are able to complete assessments in english, and the youth is able to complete therapy. exclusion criteria: * the youth currently exhibits psychosis. * the youth currently exhibits mania. * the youth is currently \<85% of their ideal body weight. * the youth is intellectually incapable of completing the study, e.g. has an intelligence quotient (iq) \< 70.