Kornimate/medical-research-clean huggingface dataset:
brain plasticity of autism in response to early behavioral intervention: a multimodal mri study

Conditions: Autism

Summary: autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. while the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for treatment is behavioral intervention. however, the pathophysiological mechanisms underlying the intervention therapy remains incompletely understood. the current project aims to explore the impacts of different early behavioral intervention methods on brain plasticity of autism using multimodal mri technique and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods.

autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. while the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for treatment is behavioral intervention. however, the pathophysiological mechanisms underlying the intervention therapy remains incompletely understood. the current project aims to explore the impacts of different early behavioral intervention methods on brain plasticity of autism using multimodal mri technique and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods. investigators collect participants' brain imaging data, eye movement data, stool samples and clinical scale score before and after intervention. investigators first investigate longitudinal effect of behavioral intervention on brain structure and function in children with autism. in addition, investigators provide new biological indexes upon multimodal large-scale brain connectomes to evaluate the curative effect of intervention. finally, investigators propose a prediction model of intervention effect based on multimodal multivariate pattern analysis methods. furthermore, investigators expect to map the state-of-the-art biomarkers on multi-modal networks to provide a new interpretation of pathophysiological mechanisms of autism.

Eligibility criteria:
inclusion criteria: * age range from 2 to 8 years old. * clinical dsm-iv diagnosis of autism. exclusion criteria: * subjects with other neurodevelopmental diseases. * subjects with contraindications to mri.

Keywords: autism brain plasticity behavioral intervention magnetic resonance imaging
human salivary gland disposition of alda-341 in patients undergoing salivary gland surgery

Conditions: Submandibular Gland Tumor; Parotid Gland Tumor

Summary: the purpose of this study is determine salivary gland disposition of d-limonene, the primary component in citrus peel and a common dietary supplement. salivary gland tissue and saliva will be collected to determine concentration of d-limonene and its metabolites in these tissues.

primary objective: to determine the bioavailability of alda-341 in salivary gland tissue. secondary objective: to determine the bioavailability of alda-341 in saliva and blood

Eligibility criteria:
inclusion criteria: * elected to undergo surgery for recent diagnosis of parotid or submandibular gland tumor * ability to adhere to study visit schedule and other protocol requirements * operable candidate base on the surgeon's note * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * nursing or pregnant * diagnosis of kidney disease, history of renal disease with creatinine \> 1.5 mg/dl, or currently on dialysis * diagnosis of end stage liver disease * any unstable medical condition * use of chemotherapy or radiotherapy within 4 weeks before first dose of study dietary supplement * unwilling to stop dietary supplements 3 weeks before first dose of study dietary supplement
upper extremity post-op splints: do they improve post-operative pain?

Conditions: Extremity Injury

Summary: the goal of this study is to determine if applying a rigid splint helps to reduce pain following operative fixation of upper extremity fractures. orthopedic trauma surgeons currently vary in their application of rigid post-operative splints versus soft dressings after certain surgical procedures based on personal preference. in this study, 100 patients undergoing operative fixation of isolated both bone forearm, radial head, olecranon, distal humerus, or humeral shaft fractures will either receive a splint or soft dressing post-operatively. their pain, medication usage and function will be tracked over the 2- week postoperative period to see if splinting has any impact on outcomes.


Eligibility criteria:
inclusion criteria: * willing and able to participate in study and complete consent * will undergo operative fixation of an isolated both bone forearm, radial head, olecranon, distal humerus fracture, or humeral shaft fracture. exclusion criteria: * pregnant women * patients with concomitant tbi or mr * polytrauma patients * pathologic fractures * patients undergoing treatment for malignancy * nyu som students, residents, faculty * prisoners * iv drug users or patients on chronic narcotics * gun shot wound victims

Keywords: upper extremity fracture
a study of dasatinib vs. high-dose imatinib (600 mg) in patients with chronic phase chronic myeloid leukemia (cml) who failed to achieve complete cytogenetic response after 3-18 months of imatinib therapy

Conditions: Leukemia

Summary: the purpose of this clinical research study is to compare the rate of complete cytogenetic response of dasatinib to imatinib therapy at 6 months after randomization in chronic phase cml patients. the safety of this treatment will also be studied.


Eligibility criteria:
inclusion criteria: * men and women ≥18 years diagnosed with chronic phase philadelphia chromosome positive (cp ph+) cml who have failed to achieve ccyr after 3-18 months of therapy with imatinib 400 mg * treatment initiation with imatinib 400 mg within 6 months of initial cml diagnosis * able to tolerate chronic administration of imatinib at the highest dose (400-600 mg) the subject has received in the past * eastern cooperative oncology group performance status (ecog ps) 0-2 * adequate hepatic and renal function exclusion criteria: * eligible and willing to undergo immediate autologous/allogeneic stem cell transplant * previous diagnosis of accelerated/blast crisis cml * subjects with clonal evolution in ph+ cells observed in ≥2 metaphases * previous documentation of t315i mutation * uncontrolled or significant cardiovascular disease * serious uncontrolled medical disorder/active infection * history of significant bleeding disorder unrelated to cml * intolerance to imatinib ≥400 mg * concurrent malignancies other than cml

Keywords: leukemia (chronic myeloid leukemia - chronic phase)
personalized atrial septostomy for heart failure

Conditions: Heart Failure; Heart Failure, Diastolic

Summary: this study aims to investigate the safety and efficacy of personalized atrial septostomy (pas) with combined use of radiofrequency-ablation and balloon-dilation (curb) in heart failure with reduced ejection fraction (hfref) and heart failure with preserved ejection fraction (hfpef).

atrial septostomy is an important palliative therapy in heart failure with reduced ejection fraction (hfref) and heart failure with preserved ejection fraction (hfpef) . though the safety of balloon atrial septostomy (bas) is satisfactory, the incidence of spontaneous closure is higher, which limits the clinical utilization of this procedure. the device-implantation improves the long-term patency. however, the created fenestration is limited with fixed size and it is further complicated with the potential device-related complications. radiofrequency catheter ablation (rfa) has the potential to cause irreversible damage around the rim of fenestration created with bas, which might prevent the re-adhesion of the septal remnants. in addition, rfa on fossae ovalis might reduce the elastic recoil of local tissue and contribute to create larger inter-atrial fenestration with same bas procedure. therefore, the combined use of radiofrequency-ablation and balloon-dilation (curb) might become a novel procedure to create a stable inter-atrial fenestration. in this study, the adult patients who have hfref and hfpef refractory to medical therapy may be eligible for this study.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years; 2. symptomatic heart failure in nyha class iii or iv ambulatory; 3. optimal medical therapy of heart failure according to european society of cardiology (esc) guidelines for last 6 months; 4. lvef ≥ 45%; 5. elevated left heart filling pressures: left ventricular end-diastolic pressure (lvedp) or pulmonary capillary wedge pressure (pcwp) ≥ 18 mmhg at rest; 6. lvedp or pcwp-mean right atrial pressure (mrap) ≥ 5 mmhg; 7. systolic blood pressure ≥ 90 mmhg. exclusion criteria: 1. acute infection or sepsis; 2. intra-cardiac mass, thrombus or vegetation; 3. evidence of right heart failure (tapse \< 14 mm); 4. pulmonary hypertension (pasp \> 60 mmhg); 5. associated atrial septal defect or large patent foramen ovale with significant left to right shunt in rest; 6. tia or stroke within the last 6 months; 7. thromboembolic events within the last 6 months; 8. hypertrophic obstructive cardiomyopathy or infiltrative cardiomyopathy as cause of heart failure; 9. valvular diseases requiring therapy according to current esc guidelines; 10. life expectancy \< 1 year for non-cardiovascular reasons.

Keywords: heart failure; atrial septostomy
radiation therapy to the head in preventing brain metastases in women receiving trastuzumab and chemotherapy for metastatic or locally advanced breast cancer

Conditions: Breast Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to kill tumor cells. it is not yet known whether radiation therapy directed at the head is effective in preventing brain metastases in patients with advanced cancer. purpose: this randomized phase iii trial is studying radiation therapy to the head to see how well it works in preventing brain metastases in women receiving trastuzumab and chemotherapy for metastatic or locally advanced breast cancer.

objectives: * to test if prophylactic cranial radiotherapy delivering 30 gy in 10 fractions will significantly reduce (from 35% to 21% at 2 years) the incidence of symptomatic brain metastases in patients treated with trastuzumab (herceptin®) for metastatic breast cancer. outline: this is a multicenter study. patients are stratified by center, type of systemic therapy (trastuzumab \[herceptin®\] monotherapy vs combination with chemotherapy), hormone receptor status, and presence of lung metastases (yes vs no). patients are randomized to 1 of 2 treatment arms. * arm i: patients receive taxane/trastuzumab therapy for 6 weeks. while continuing taxane/trastuzumab therapy, patients then undergo 10 fractions of concurrent prophylactic cranial radiotherapy in the absence of disease progression or unacceptable toxicity. * arm ii: patients receive taxane/trastuzumab therapy without concurrent prophylactic cranial radiotherapy. all patients undergo quality of life assessments every 8 weeks for 9 months. after completion of study treatment, patients are followed periodically for at least 1 year.

Eligibility criteria:
disease characteristics: * histologically proven breast carcinoma * metastatic or locally advanced disease * must demonstrate her2 3+ positivity on ihc or 2+ over-expression and fish test demonstrating c-erb2 gene amplification * no known or suspected brain metastases or cns disease, as defined by the presence of any of the following key symptoms: * headache * nausea and/or vomiting * clinical signs of raised intracranial pressure * seizures * focal symptoms * cognitive dysfunction * affective disorder * hormone receptor status not specified patient characteristics: * female * postmenopausal status not specified * ecog performance status 0 or 1 * patients must a-priori be suitable for trastuzumab (herceptin®) +/- chemotherapy in terms of bone marrow, hepatic, and renal function * no prior history of cerebrovascular disease or neurological disorder including seizures prior concurrent therapy: * no prior cranial radiotherapy * no prior neurosurgery

Keywords: recurrent breast cancer stage iiia breast cancer stage iiib breast cancer stage iiic breast cancer stage iv breast cancer
inspiratory muscle strength training and incentive spirometer on postmenopausal asthmatic women

Conditions: Asthmatic; Postmenopausal Symptoms

Summary: objective: to compare the effectiveness of inspiratory muscle training (imt) and incentive spirometer on ventilatory functions in post-menopausal asthmatic women. participants and methods: a total of forty postmenopausal women suffering from asthma, their ages ranged from 50 to 60 years old, and their body mass index of the patient don't exceed 30kg/m2. they were recruited from patient chest clinic in kasr -el- ainy teaching hospital, cairo university, egypt.

they signed a consent form, confidentiality was assured. they assigned into two groups (a) who received inspiratory muscle training in the form of: inspiratory threshold muscle trainer in addition to traditional chest physical therapy intervention (deep breath, cough training) while patients in group (b): received traditional chest physical therapy intervention and incentive spirometer, three sessions per week for six weeks. patients in both groups were assessed before treatment (pre-training) then after treatment (post-training) (after 6 weeks) to measure lung functions using electronic spirometer. the training program was carried in the duration from january 2019 to july 2019.

Eligibility criteria:
inclusion criteria: * forty postmenopausal women suffering from asthma * their ages were ranged from 50 to 60 years, * their body mass index (bmi) don't exceed 30kg/m2. * all participants were asthmatic patient * clinically and medically stable cases exclusion criteria: * participant who had chest infection, * malignant diseases, * patients with chest trauma.

Keywords: inspiratory spirometer postmenopausal asthma
evaluation of a serious game for patients with bipolar disorder involved in a psychoeducation group

Conditions: Bipolar Disorders; Euthymic Status

Summary: bipolar disorder is a condition characterized by succession of episodes- manic, hypomanic, and depressive episodes. major risks factors of relapses are poor compliance, sleep disorder, and toxics consumption. the aims of psychoeducation programs are to increase compliance and knowledge about bipolar disorder. serious game are supposed, in bipolar disorder, to strengthen the efficacy of psychoeducation programs. bipolife® is a serious game which purpose is to help bipolar patients to deal with their conditions, through 3 mains messages : to pursue the treatment, to have daily routine and to request the psychiatrist in case of relapse. this is a multicentric randomized controlled study with two harms parallels. after a classic psychoeducation group program, patients are randomized in two groups : interventional group and control group with treatment as usual. the main objective is to evaluate the observance in the two groups. the other objectives are to evaluate daily routine, global functioning, and access to health care. evaluations are realized at one and four months after inclusion visit. acceptability and satisfaction about the serious game bipolife® will be assessed in the interventional group.

bipolife® is a serious game for bipolar patients, developed by astra zeneca laboratory in collaboration with a french company named ubisoft. the aim of this interactive tool is to help patient to have a better understanding of their condition and to identify their daily routine which can impact on it. three visits : at the inclusion visit (v0), on the 15days following the end of the psychoeducation group, the investigator evaluate mood, habits, daily routine, and verify inclusion criteria of the participants, in particular euthymic status. the participants are randomized by bloc in each center, in two groups : interventional group (bipolife®) and control group. instructions on interventional group are to periodically connect to bipolife until next visit. on the first visit, one month later (v1) and on the second visit, four months later (v2), the investigator evaluate compliance, routine habits and mood.

Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder according to the diagnostic and statistical manual (dsm) iv * euthymic status at least since 3 months * participation to a psychoeducation group ending on the 15 last days * realized at less 50% of the sessions of psychoeducation group * free access to a computer with internet connection * signed informed consent exclusion criteria: * decline of participation * patient on protective measures (guardianship or trusteeship)

Keywords: psychiatry randomized controlled trial bipolar disorder serious game compliance psychoeducation
the association between chlorhexidine bathing and central line-associated infections in medical intensive care units

Conditions: Central Line-associated Bloodstream Infection (CLABSI)

Summary: we conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% chg wipes every other day and the occurrence of central line-associated infections (clabsi) in patients within the medical intensive care unit (micu).

this study defined the post-intervention period as july 1, 2017, to june 30, 2022. during this period, one of the three medical intensive care units (micus) in ntuh implemented chlorhexidine gluconate (chg) bathing as part of their daily care routine (chg group). this decision was made in response to a higher incidence rate of vancomycin-resistant enterococcus (vre) bacteremia observed in that particular micu during the preceding six months (pre-intervention period: january 1, 2017, to june 30, 2017), compared to the other two micus. the remaining two micus continued to provide usual care, which involved bathing patients with towels soaked in water and soap on a daily basis.

Eligibility criteria:
inclusion criteria: * all patients who were admitted to the micu between january 2017 and june 2022 exclusion criteria: * patients aged under 18 years old
elazop switching study in korea

Conditions: Open Angle Glaucoma

Summary: the purpose of this study is to assess the safety and efficacy of switching to elazop from prior pharmacotherapy in patients with open-angled glaucoma.


Eligibility criteria:
inclusion criteria: * 18 years of age or older. * clinical diagnosis of ocular hypertension, primary open-angle or pigment dispersion glaucoma in both eyes. * must be on a stable regimen of intraocular pressure (iop) lowering medication (i.e., either a single therapeutic agent or two separate ocular hypotensive agents) for at least one month prior to the screening visit. * must have iop considered to be safe (in the opinion of the investigator), in both eyes, in such a way that should assure clinical stability of vision and the optic nerve throughout the study period. * must be willing to discontinue the use of all other ocular hypotensive medications prior to receiving the study medication for the entire course of the study. * other protocol-defined inclusion criteria may apply. exclusion criteria: * known medical history of allergy, hypersensitivity, or poor tolerance to any component of the preparations to be used in the study that is deemed clinically significant in the opinion of the principal investigator. * intraocular conventional surgery or laser surgery in either eye less than three months prior to the screening visit. * history of ocular herpes simplex. * pregnant or lactating. * participation in any other investigational study within 30 days of screening visit. * other protocol-defined exclusion criteria may apply.

Keywords: open angle glaucoma oag elazop azarga brinzolamide/timolol combination
safety of preoperative carbohydrate loading in diabetic patients

Conditions: Carbohydrate Intolerance; Diabetes Mellitus Type 2

Summary: the purpose of this study is to investigate the safety of preoperative carbohydrate loading in diabetic patients undergoing general anesthesia


Eligibility criteria:
inclusion criteria: * elective surgery * type 2 diabetes mellitus on oral hypoglycemic agents * american society of anesthesiologists physical status 2 or 3 * ages 18 or more * approve to participate exclusion criteria: * ambulatory surgery * bmi \>35 * history of gastric or esophagus surgery * history of gerd, dyspepesia or * anticipated difficult intubation (previous iii or more cormack and lehane's grade, mallamgrade, mallampati scpati scoreore iii or moreiii or more, propro/retro/retrognathism, gnathism, thyromental distance\<6.5cm, thyromental distance\<6.5cm, limited mouth openinglimited mouth opening)

Keywords: carbohydrate intolerance diabetes mellitus diabetes mellitus, type 2 carbohydrate loading
virtual reality to reduce intra-procedural anxiety and sedation needs during procedures

Conditions: Arrhythmia

Summary: researchers are assessing whether use of a virtual reality experience, used during the procedure, can reduce anxiety and improve satisfaction related to the procedure, especially when no or little sedation is being used.


Eligibility criteria:
inclusion criteria: * patients undergoing invasive ep procedures with plan for no or minimal conscious sedation exclusion criteria: * patients unable to consent
parallel versus perpendicular technique for genicular radiofrequency

Conditions: Knee Osteoarthritis

Summary: although there are different ways of performing genicular nerve radiofrequency on knee pain, to our knowledge, there is no stuies comparing the clinical outcomes of a parallel technique vs. a perpendicular technique. we aimed to compare the effectiveness of these both techniques.


Eligibility criteria:
inclusion criteria: - exclusion criteria: * intra-articular injections in the knee during the 3 months prior to procedure * chronic pain syndrome * lumbar radicular pain * patients who are unwilling or mentally incapable to complete the study questionnaires.