Kornimate/medical-research-clean huggingface dataset:
effects of home-based inspiratory muscle training in patients with ipf

Conditions: Idiopathic Pulmonary Fibrosis; IPF

Summary: the aim of this study is to investigate the effects of the home-based inspiratory muscle training program on lung functions, dyspnea, inspiratory muscle strength, functional capacity and quality of life in patients with idiopathic pulmonary fibrosis. patients are evaluated before the inspiratory muscle training and after 8 weeks of training.

the imt protocol consisted of home-based high-intensity daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an imt threshold device (threshold imt philips® respironics, inc). the intensity of the training was set to 50% of each patient's maximal inspiratory pressure measured every week and was adjusted weekly based on the modified borg scale from 4 to 6 regarding respiratory effort performed during the session. patients are evaluated before the inspiratory muscle training and after 8 weeks of training.

Eligibility criteria:
inclusion criteria: * diagnosing idiopathic pulmonary fibrosis by a pulmonologist; * aged between 40 and 75 years; * volunteering to research; * stable clinical condition (same medication routine and/or no acute exacerbation in the last for the last 4 weeks). exclusion criteria: * inability of the participant to understand or perform the procedures proposed during the evaluations or training program. * participating in any pulmonary rehabilitation programs; * a previous pneumonectomy or lobectomy operation; * pneumonia in the last 4 weeks; * any pulmonary infection during the study; * requirement for supplemental oxygen therapy while resting. * having covid-19 disease (during the study or in the past) * orthopaedic or neurological conditions affecting the ability to independent walking

Keywords: idiopathic pulmonary fibrosis inspiratory muscle training home-based rehabilitation
comparison of conventional and custom photorefractive keratectomy (prk)

Conditions: Myopia

Summary: the study objective is to compare the clinical outcomes using wavefront guided prk with iris registration and conventional laser prk using fda-approved laser technology on the same patient.

patients undergoing bilateral prk on the same day will have one eye randomly assigned to custom wavefront guided prk and the fellow eye treated with conventional prk.

Eligibility criteria:
inclusion criteria: * patients deemed to be suitable candidates for bilateral prk exclusion criteria: * patients desiring monovision correction rather than bilateral distance correction
pre-oxygenation methods in bariatric patients

Conditions: Obesity; Anesthesia; Bariatric Surgery Candidate

Summary: the purpose of the study is to compare effectiveness of different methods of achieving pre-oxygenation in bariatric patients. the investigators intend to compare facemask pre-oxygenation with a high-flow humidified nasal oxygen. the primary outcome measure of interest is time to desaturation to 92% or 18 minutes of apnoea.

general anaesthesia involves giving patients anaesthetic and muscle relaxant medications to allow transition to sleep and airway relaxation to permit laryngoscopy, respectively. during laryngoscopy, a breathing tube is placed to 'secure' the airway. there is therefore a length of time from administration of these medications to when the breathing tube is placed, when the patient is not breathing and the airway is not secured. this time is known as apnoea time. in a patient who is not breathing, blood oxygen levels fall to dangerously-low levels, within 1-2 minutes. in order to prevent this, patients breathe 100% oxygen before induction of anaesthesia as part of a process known as pre-oxygenation. there are different ways of delivering pre-oxygenation, but the common aim is to increase the oxygen reservoir within the lungs to give the anaesthetist more time to place the breathing tube. with good pre-oxygenation, apnoea times of up to 7 minutes are possible. apnoea time is a potentially hazardous period during induction of anaesthesia and it is particularly so in patients with severe obesity. on the one hand, obesity makes the upper airway anatomy difficult, and on the other hand, lung collapse (atelectasis) caused by abdominal contents compressing the base of the lungs reduces the amount of oxygen available within the lungs. apnoea time can be as short of 30 seconds. identifying the most effective method of pre-oxygenating bariatric patients can therefore significantly improve the safety of delivering general anaesthesia to these patients.

Eligibility criteria:
inclusion criteria: * able to provide informed consent. * undergoing general anaesthesia . * between the ages of 18 and 80 years. * body mass index (bmi) greater than 40 kgm-2. exclusion criteria: * unable to give informed consent. * significant cardiac history which is defined as current angina, myocardial infarction \<12 months before the date of the procedure. * significant peripheral vascular disease defined as claudication on minimal exertion or ankle-brachial index of \<0.7, a stroke or a transient ischaemic attack \<12 months before the procedure. * presence of significant heart-valve disease or congestive heart failure. * significant lower respiratory disease including brittle asthma; chronic obstructive pulmonary disease (gold stages 3 or 4). * strong predictors of both difficult intubation and difficult facemask ventilation on anaesthetic airway assessment. * patient with american society of anesthesiologists (asa) grade of 4 for any reason.

Keywords: obesity bariatric surgery
use modular medical equipment vehicle in mobilization of patient with chest tube

Conditions: Mobility Limitation; Sleep Quality; Pain; Comfort; Time of the Removal Chest Tube

Summary: in this study, it was aimed to examine the effect of the modular carrying system on the outcomes of care in the mobilization of patients with a chest tube. the population of the study consisted of patients followed in yedikule chest diseases, and thoracic surgery training and research hospital between october 2019 and january 2021, and the sample consisted of 83 patients who met the inclusion criteria. the study was performed with the intervention group (n=37) mobilized with the modular medical equipment carrying vehicle and the control group (n=46) mobilized with the routine application.

within the scope of the study, a modular medical equipment carrying vehicle was developed by the researchers to ensure the safe and comfortable mobilization of patients with chest tube and additional medical equipment. this vehicle has been designed to maintain the level of the chest tube during mobilization and to prevent it from tipping over.patients in the intervention group were mobilized with the help of this modular medical equipment carrying vehicle for 20 minutes at least 6 times a day. patients in the control group were mobilized at least 6 times a day for 20 minutes with clinical routine practice.

Eligibility criteria:
inclusion criteria: * chest tube inserted due to open surgery, hemodynamically stable, followed up in the clinic for at least 5 days, first mobilized after chest tube inserted exclusion criteria: * have a mental or psychological illness, hemodynamically unstable

Keywords: care outcomes mobilization chest tube
long term study of amlodipine 10mg with hypertension for whom amlodipine 5mg is insufficient

Conditions: Hypertension

Summary: to investigate the safety and efficacy of the long-term use of amlodipine 10 mg in subjects who will be able to enter a long-term study after completing the parent study "a double-blind comparative study between amlodipine 5 mg and 10 mg in patients with essential hypertension for whom amlodipine 5 mg is insufficiently effective" (protocol no.: a0531085).

nct00415623 (protocol a0531085)

Eligibility criteria:
inclusion criteria: * patients who had completed the preceding study a0531085, phase iii study, who the investigator judged to be able to further treatment of long term administration in terms of efficacy and safety * patients who had a treatment compliance rate of at least 80% exclusion criteria: * the patient who met the discontinuation criteria in the preceding study a0531085
molecular mechanisms of disease relapse after allogenic stem cell transplantation in mds patients

Conditions: Myelodysplastic Syndromes

Summary: this is a biological study for adult mds patients who undergo hsct procedure. viable bone marrow samples will be collected and cryopreserved from mds patients before transplantation and at clinical disease recurrence. cd34+ blast cells at disease relapse after hsct will be compared with cd34+ cells collected before transplant to study genomic and transcriptomic changes.

this is a biological study for adult mds patients who undergo hsct procedure.the research is focused on the study of biological mechanisms of disease relapse after hsct in mds to provide the rationale to develop pre-emptive strategies in patients with high risk of transplant failure. viable bone marrow samples will be collected and cryopreserved from mds patients before transplantation and at clinical disease recurrence. cd34+ blast cells at disease relapse after hsct will be compared with cd34+ cells collected before transplant by using single-cell sequencing. to study genomic and transcriptomic changes in cd34+ blast cells at disease relapse after hsct will be used target-seq in parallel with unbiased whole-transcriptome analysis.

Eligibility criteria:
inclusion criteria: * diagnosis of mds according to 2016 who criteria * aged 18y or older * patients who will receive allogeneic stem cell transplantation (hsct) * signed written informed consent according to ich/eu/gcp and national local laws exclusion criteria: * second hsct procedure.
my smart age with hiv: smartphone self-assessment of frailty

Conditions: HIV Infection; Aging

Summary: understanding the complexity of aging and frailty in chronic hiv infection motivated italian team members to begin to build a frailty index (fi) including 37 health variables at the modena hiv metabolic clinic (mhmc). the validation of fi in hiv patients have been recently published, and more data comparing fi in hiv infected vs un-infected people, have been presented at international meeting and are at present submitted for publication. the research consortium (mhmc, hcc and hhmp) of this study was motivated to begin preliminary work in consideration of the similar multidisciplinary approach in ageing care and capacity to address health status in ageing hiv patients using shared definitions of co-morbidities, multi-morbidity and measures of physical function and cognition impairment, disability and quality of life. the investigators wanted to overcome the major criticism intrinsic in the fi, that is the needs to collects many variables not easily available in most hiv centres. the the investigators approach is to make patient living with hiv (plwh), be the source of health variables taking advantage of information and communication technologies available with smart phones and fitness tracking device, collecting physiological parameters and patient related outcomes.

in this study the investigators plan to empower elderly hiv patients via health promotion, assessing reduction in health deficit and improvement in quality of life using my smart age (mysawh) application. mysawh is an interactive mobile application designed to empower elderly hiv patients in health promotion through self assessment of ageing transition using a fi. fi is generated from health variables which include physical function data routinely collected by fitness tracking devices, ecological momentary assessment data collected with smart phones and physician health data collected during patient visits. the change in frailty index over time describes health transition. although health generally worsens with age, the relationship between aging and health is dynamic and periodic improvement and stability in frailty index may be the result of the patients engagement in health promotion and improved life style.

Eligibility criteria:
inclusion criteria: * hiv infection on art * hiv1-rna\<40 c/ml for at least 6 months * age stratification: * 50 pts (per centre) aged 50-64 years * 50 pts (per centre) aged ≥ 65 years * routine access to a smart phone and willingness to use the fitness tracking device * willingness to be trained to use an interactive mobile application exclusion criteria: -
weighted blankets with infants with nas

Conditions: Neonatal Abstinence Syndrome

Summary: infants with neonatal abstinence syndrome (nas) who are cared for in a neonatal intensive care unit (nicu) often display symptoms including hyperactivity, irritability, jitteriness, poor feeding, and poor sleep patterns. the recommended first line of treatment to relieve these symptoms involves nonpharmacological interventions. the purpose of the current pilot study is to provide preliminary data to assist in the design of a larger scale study to examine one nonpharmacological intervention, weighted blankets. the pilot study will assess the feasibility of a cross-over randomized controlled design to study the impact of a weighted blanket on infants' symptoms of nas. the aims of the study are: aim1: to determine the feasibility of recruiting patients for a study evaluating the use of weighted blankets in the care of infants with nas aim 2: to determine the feasibility and safety of the study procedures aim 3: to examine whether there is clinical benefit to using weighted blankets for the treatment of symptoms in infants with nas. after informed consent is obtained, infants will be randomized to have either a weighted blanket or a non-weighted blanket placed on them first. a cross-over design will be used so all infants will experience both the non-weighted and weighted blankets. thirty minutes before each feeding, baseline vital signs and finnegan score will be obtained. then, a blanket (weighted or non-weighted) will be placed on the infant for 30 minutes. infants will be directly monitored and on heart rate/respiratory rate monitors while the blanket is applied. vital signs and finnegan scores will be obtained at the end of 30 minutes of blanket placement, infants will be fed, and vital signs and finnegan scores will be obtained again 30 minutes after the blanket was removed. descriptive statistics will be used to determine the enrollment rate and feasibility of the protocol. nonparametric statistics will be used to compare total finnegan scores for infants with the weighted blanket applied compared to infants with a non-weighted blanket applied. changes in finnegan scores will be examined to estimate an effect size to use in a power analysis for a future larger effectiveness study.


Eligibility criteria:
inclusion criteria: * admitted to the nicu * gestational age \> 37 weeks * positive maternal drug screen at delivery exclusion criteria: * clinical staff does not give permission to enroll the patient * had intrauterine growth restriction (iugr) * has any medical diagnosis in addition to nas diagnosis * has a weight below the 10th percentile
virtual reality for the improvement of patients understanding of disease and treatment (mrgrt)

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial explores if using virtual reality (vr) headsets will help to improve patient understanding of their disease and decrease anxiety about treatment. three-dimensional (3d) images may help the patient visualize their tumor and location better and therefore understand potential side effects. visualizing a virtual representation of the magnetic resonance imaging (mri) linear accelerator (linac) may decrease treatment related anxiety.

primary objective: i. examine patient reported comprehension of their tumor characteristics and treatment plan following 3d virtual reality review of their imaging. secondary objective: i. examine patient reported treatment related anxiety prior to and following virtual reality (vr) simulation of the mri linac treatment process. outline: patients are assigned to 1 of 2 cohorts. cohort i: patients receive two-dimensional (2d) image review using standard computer screen on study. patients undergo mri and computed tomography (ct) imaging at screening and on study. cohort ii: patients receive image review using virtual reality stimulation on study. patients also view mri treatment room using virtual reality stimulation. patients undergo mri and ct imaging at screening and on study.

Eligibility criteria:
inclusion criteria: * age: above 18 years * participants must be histologically proven neoplasm * planned to undergo radiation treatment using the mr linac exclusion criteria: * inability to tolerate virtual reality headset * non-english speaking patients * pediatric patients are ineligible
study of knee replacements for patellofemoral osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: this is a randomized comparison of pfa and tkr in treatment of isolated patellofemoral osteoarthritis.

isolated patellofemoral osteoarthritis can be a disabling condition of the knee necessitating knee arthroplasty. it is debated whether total knee replacement or isolated patellofemoral replacement is the better treatment option. this randomized trial attempts to give a qualified answer to the debate by comparing clinical outcome (range of movement, stability, effusion, patellofemoral tracking, tenderness, stair climbing), patient self assessment scores (eq-5d, oxford knee score, koos, sf-36, aks), complications (infections, revisions), longevity (survival analysis) and cost (direct and indirect) for the two implant types. the avon patellofemoral implant has been chosen, as this is the patellofemoral implant with the best documentation. the pfc sigma cr total knee implant has been chosen as it a current standard implant and market leader.

Eligibility criteria:
inclusion criteria: * isolated pf-oa exclusion criteria: * medial or lateral oa

Keywords: osteoarthritis knee knee cap patella patellofemoral
real world study of four pd-1 agents in china

Conditions: Thoracic Cancer; Gynecologic Cancer; Abdomen Tumors; Malignant Melanoma

Summary: consecutive patients treated with pd-1 therapy in qingdao city were included in our study. the effecy and safety of the four pd-1 agents according to clinical outcomes in real world will be studied.

consecutive patients treated with pd-1 therapy in qingdao city were included in our study. the effecy and safety of the four pd-1 agents according to clinical outcomes in real world will be studied. orr will be studied of the four pd-1 agents（nivolumab, pembrolizumab, toripalimab, sintilimab）

Eligibility criteria:
inclusion criteria: * patients with lung cancer, liver cancer and other solid cancers * histologically or cytologically confirmed diagnosis cancer treated with pd-1 agents * at least one measurable lesion * eastern cooperative oncology group (ecog) performance scale 0 or 1 adequate organ function exclusion criteria: * patients treated with pd-1 agents less than 2 terms
endodontic treatment of primary teeth using mineral trioxide aggregate paste

Conditions: Teeth, Endodontically-Treated

Summary: the maintenance of primary teeth until their exfoliation has been one of the main purposes of pediatric dentistry, are they representing the fundamental basis for proper occlusion of the permanent dentition. often, injuries or extensive dental caries reach the pulp of deciduous teeth making maintenance on these dependent endodontic treatment arc. thus, this study was to conduct a randomized clinical trial is to evaluate the performance of endodontic treatment in primary teeth using mta paste, comparing to vitapex.

after approval by the ethics committee of the patients faculty of dentistry, university of são paulo that having root canal filling of primary teeth will be invited to participate in the study. a clinical examination and prior radiographic diagnosis will be-held. the patient will be randomized to one of two groups and will be made the endodontics by a dentist. the patient will be accompanied with periods of one week, one month and three months by a blinded evaluator. the outcome will be the success or failure of endodontic treatments evaluated through permanent tooth in the arch on clinical and radiographic conditions of normality. the longevity of the treatments will be evaluated by estimating survival rates by kaplan-meier. the differences between the survival rates according to the type of proposed endodontic treatment will be analyzed using the log-rank test with a minimum significance level of 5%.

Eligibility criteria:
inclusion criteria: * primary teeth with pulp diagnosis and need endodontic treatment * patients whose guardians consent to their participation in the survey * fistula or abscess * bone rarefaction or visual diagnosis * teeth in the remaining tooth structure and location of the injury rehabilitation permit do not have internal or external resorption involving more than one third of the root length * have no bone loss in lateral root and disruption crypt and the presence of at least half of root exclusion criteria: * health problems systemic * congenital facial deformities * facial tumors * syndromes
quadratus lumborum block versus erector spinae plane block in extracorporeal shock wave lithotripsy(eswl)

Conditions: Pain; Lithiasis

Summary: this study is designed to compare analgesic effect of both the ultrasound (us)-guided qlb and espb blocks during eswl and their effect on stone fragmentation.

urinary tract calculi, one of the most common benign urological diseases, is seen in 12% of patients and has a recurrence rate of approximately 50%. management of renal calculi is known to be affected by many factors, specially tolerance of pain during eswl and how it is controlled. pain experienced during eswl is thought to occur when shock waves from the lithotripter reach superficial structures such as skin and also deeper structures such as the ribs, nerves and the kidney capsule. there are three main factors that contribute to the propagation of pain at these structures: shock wave (sw) pressure, distribution, and focal area size . conventionally, pain during eswl is managed by basic analgesics such as nsaids, which can also aid in stone clearance. other methods of analgesia also have been studied and tested. quadratus lumborum block (qlb) was first described by blanco in 2007, it blocks t7-l1 nerve fibres in most of the cases. studies have reported its use in the management of postoperative pain after hip surgeries. "erector spinae plane block" (espb) is another such block, that is increasingly tried for the management of postoperative pain for breast surgery, thoracic surgery, and also upper abdominal surgeries. espb when given at the lumbar region gives blockade from c7-t2 to l2-l3.

Eligibility criteria:
inclusion criteria: * informed written consent obtained * age 18-60 * both sex * american society of anesthesiologists(asa) physical status: i, ii * stone pelvis less than 2.5 cm * indicated for eswl exclusion criteria: * refusal of participation by parents or caregivers. * asa physical status: \> ii * stone pelvis \>2.5 cm * chronic pain * on chronic nsaid or opioid * substance addict * known local anesthetic drug sensitivity. * preexisting infection at block site * coagulopathy or anticoagulation.
evaluation of treatment with coenzyme q10 and l-carnitine on semen parameters in infertile men with idiopathic oligoasthenoteratospermia

Conditions: Infertility Unexplained; Oligospermia

Summary: evaluation of treatment with coenzyme q10 and l-carnitine on semen parameters in infertile men with idiopathic oligoasthenoteratospermia

evaluation of treatment with coenzyme q10 and l-carnitine on semen parameters in infertile men with idiopathic oligoasthenoteratospermia a placebo controlled clinical trial

Eligibility criteria:
inclusion criteria: * of in¬fertility of 1 year or more without the use of contraception exclusion criteria: * o active genital infections. * patients with ejaculatory dysfunction * azoospermia

Keywords: infertility oligospermia coenzyme q1o