Kornimate/medical-research-clean huggingface dataset:
barrier measures to limit covid-19.nosocomial transmission: a cross-sectional evaluation

Conditions: Caregivers; COVID-19

Summary: use lay language. the covid-19 pandemic hit france in march 2020 and stage 3 of the epidemic justified the introduction of national and unprecedented containment measures from march 17, 2020. the montpellier chu experienced peak hospitalizations of covid-19 infections in late march. the estimate of the proportion of infected people in occitania, south of france, for the 11th of may 2020 is 3.1% (95% ci: 1.9-5.9) for the occitania region, to which montpellier belongs. in the context of the covid-19 epidemic, notably due to the absence of pharmacological or vaccine prophylaxis, barrier measures were of crucial importance, especially for exposed caregivers. these measures include an adaptation of individual behavior, the creation of a so-called "covid" hospital, the wearing of specific equipment in all departments, the use in the rooms of covid-19 patients of a gown, an apron, gloves, and a ffp2 type mask in the event of contact and sampling, protocolized and standardized bio-cleaning measures, a reorganization of the premises and the definition of specific circuits. in view of the second wave of the epidemic, estimating the effectiveness of the barrier measures is of major importance. the investigators therefore propose an evaluation of the effectiveness of these measures, by comparing the serological prevalence of infection among caregivers working directly in covid units compared to caregivers working in services excluding the management of covid-19 patients. systematic evaluation in covid-19 units of sarc-co-v2 infection will also be assessed, with naso-pharyngeal swabs.


Eligibility criteria:
inclusion criteria: * exposed group: exposed caregivers and agents who worked in covid units (medicine, resuscitation, screening) until their date of collection. an exposed agent or caregiver is defined by the entrance of rooms with a covid-19 infection during their professional activity. * low or unexposed group: caregivers or agents who have worked in non-covid units in a non-covid hospital exclusion criteria: - refusal to participate

Keywords: barrier measures
valtrex once daily for viral shedding in herpes simplex virus 2 (hsv-2) seropositive subjects. valtrex® tablet is a trademark of glaxosmithkline group of companies.

Conditions: Infections, Herpesviridae

Summary: eligible subjects will be randomized to receive valtrex® tablet 1g or placebo once daily for 60 days in a two-way crossover study with a washout period of 7 days between treatment periods.


Eligibility criteria:
inclusion criteria: * in overall general good health. * hsv-2 (herpes simplex virus-2) seropositive at screening. exclusion criteria: * have active lesions consistent with genital herpes. * previous history of symptomatic genital herpes. * history of recurrent, undiagnosed symptoms consistent with genital herpes.

Keywords: viral shedding recurrent herpes genital herpes
synthetic human secretin in children with autism

Conditions: Autism

Summary: the purpose of the study is to determine whether multiple doses of secretin are safe and effective in the treatment of children with autism.


Eligibility criteria:
autism
metabolite levels in ovarian cancer patients receiving maintenance parp inhibitors

Conditions: Ovarian Carcinoma

Summary: this study evaluates blood samples and compares levels of metabolites (levels of vitamins, carbohydrates, proteins, etc., that are in the blood), before and after the plasma exchange in patients scheduled to receive immunotherapy for their ovarian cancer. the information gained from this study may help researchers better understand the side effects from each treatment and possibly lessen those side effects for future treatments.

primary objective: i. to determine the extent to which parp inhibitor (parpi) treatment reduces systemic levels of mesenchymal stem cell (msc)-derived cancer support factors in patients with cancer. outline: patients undergo collection of blood samples prior to drug initiation, weekly thereafter for the first month of therapy, monthly for the first month, and at disease progression or after cessation of treatment to monitor for toxicity. blood samples are analyzed. patients' medical charts are also reviewed to determine outcomes after parp inhibition.

Eligibility criteria:
inclusion criteria: * adults * patients with ovarian cancer starting parp inhibitor treatment exclusion criteria: * patients unwilling to return for blood draws, patients unwilling to continue parp inhibitor treatment for at least one month
the effect of platelet rich plasma on lateral epicondylitis

Conditions: Lateral Epicondylitis; Elbow Pain

Summary: the purpose of this study is to compare the effects of platelet rich plasma, whole blood and saline vehicle on the natural course of lateral epicondylitis.

lateral epicondylitis, also known as "tennis elbow", is the most common work-related disease of the upper extremity. usually it has favorable natural healing-tendency, but sometimes it is responsible for long-lasting disability. the pathogenesis of this disease has remained unclear, however it has been speculated that the role of inflammation is smaller than previously believed. instead, anatomical and vascular factors may play a much greater role. the evidence for the operative treatment is lacking, and the conservative treatment is therefore preferred. the conservative treatment used to rely largely on corticosteroid injections to the extensor muscle insertions. however, it has been shown that corticosteroids, in fact, tend to increase the subjective pain in the long run. several studies -- most of them unfortunately underpowered -- have been carried out to find an efficient conservative treatment to this disease, but none of them has turned out to be significantly better than others. during the last couple of years, platelet rich plasma (prp) has been used as a treatment in several musculoskeletal diseases (e.g. fracture healing, cartilage regeneration, wound healing). prp is a substance centrifuged from patient own blood. there are a couple of studies regarding the use of prp in lateral epicondylitis. the results are mostly positive; however it has not been thoroughly shown that it would be more effective than patient's whole blood. the hypothesis of this study is that prp is more effective in the treatment of lateral epicondylitis than whole blood or saline vehicle injection. the primary outcome measures are pain (vas) and the disabilities of the arm, shoulder and hand -score (dash).

Eligibility criteria:
inclusion criteria: * the duration of symptoms over 3 months * primary conservative treatment (physiotherapy, nsaid, ...) has been tried exclusion criteria: * significant systemic diseases * any surgical operation of the particular elbow

Keywords: platelet rich plasma whole blood injection lateral epicondylitis tennis elbow
endovascular neuromodulation treatment for heart failure patients (endo-hf)

Conditions: Heart Failure

Summary: the purpose of the endo-hf study is to determine the safety \& performance of the harmony system for the treatment of heart failure


Eligibility criteria:
inclusion criteria: * subject is diagnosed as chronic heart failure nyha class ii-iii * subject should be receiving optimal medical treatment * subject signed and dated informed consent exclusion criteria: * subject has severe aortic sclerosis or calcification * subject diagnosed with severe aortic valve disease * subject has severe mitral stenosis * subject involved in any concurrent clinical investigation * subject with cerebral vascular accident or transient ischemic attack prior to enrollment * subject diagnosed with marfan syndrome * subject with moderate or severe chronic obstructive lung disease * subject is allergic to iodine or contrast media * subject with prior cardiac transplant or heart transplant candidate * subject with a life expectancy of less than 12 months

Keywords: heart failure cardiovascular diseases heart diseases
effects of bracing on knee osteoarthritis (oa)

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis (oa) is characterized by complaints of knee pain, aching and stiffness that commonly alter the way one will climb stairs and walk reducing an individual's function and the activities they may perform on a day-to-day basis. providing a person with a knee brace designed for oa can help unload the arthritic part of the knee, thereby reducing pain and lead to improved function. the purpose of this study is to determine if use of the rebel reliever knee brace manufactured by townsend design can reduce pain and stiffness, improve strength and balance, and enhance functional activities such as stair and level gait, and ultimately lead to increased participation in the community.


Eligibility criteria:
inclusion criteria: * male or female * aged between 35 and 70 * present with diagnosed unicompartment osteoarthritis of the knee exclusion criteria: * severe cardiac or pulmonary disease that limits ability to walk. * presence of hip, ankle or foot oa or other lower limb pathology that limits ability to walk. * bilateral knee oa * previous use of an oa knee brace * surgical procedure in either leg within the past 6-months * anthropometrics that are incongruent with manufacturer's specifications for the rebel reliever

Keywords: oa arthritis knee oa
evaluation of efficacy and safety of milsaperidone as adjunctive therapy in patients with major depressive disorder

Conditions: Major Depressive Disorder (MDD)

Summary: the purpose of this study is to determine the efficacy and safety of milsaperidone compared to placebo as adjunctive therapy in patients with major depressive disorder


Eligibility criteria:
inclusion criteria: * male or female patient 18 to 65 years of age, inclusive; * meets dsm-5-tr criteria for mdd * currently having an inadequate response to antidepressant therapy as confirmed by the investigator using the antidepressant treatment response questionnaire (atrq) exclusion criteria: * within the patients lifetime, has a confirmed dsm-5-tr psychiatric diagnosis other than mdd * within 6 months of screening, has a confirmed dsm-5-tr psychiatric diagnosis other than mdd that is a primary diagnosis * within 12 months of screening, has had any other psychiatric condition (other than mdd) that has been the main focus of treatment
the shield study-silicosis

Conditions: Silicosis

Summary: an observational cohort study to derive biomarkers which are able to more accurately diagnose silicosis, as well as predict disease progression, assess response to treatment, and hasten therapeutic discovery.

background: silicosis is a fatal lung disease caused by inhaling silica particles. australia is currently facing an epidemic with hundreds of young workers having contracted silicosis from machining engineered stone. aims: to establish the shield cohort and associated shield biobank to drive further discovery including assessing the efficacy of whole lung lavage for accelerated silicosis, uncovering disease biomarkers, and druggable targets. participants: 75 participants who are respirable crystalline silica exposed workers, (this includes n=30 with silicosis, n=15 with progressive massive fibrosis and n=30 with no pneumoconiosis). methods: advanced microscopy, 'omic platforms and single cell rna sequencing. outcome: the shield study builds on the knowledge gap to accurately diagnose silicosis, as well as predict disease progression, assess response to treatment, and hasten therapeutic discovery

Eligibility criteria:
inclusion criteria: * all workers with a history of significant engineered stone exposure will be potentially eligible. exclusion criteria: -

Keywords: silicosis pneumoconiosis lung diseases
efficacy of erector spinae plane block versus infraclavicular subomohyoid block in shoulder surgery

Conditions: Postoperative Pain; Shoulder Pain

Summary: the study aimed to compare erector spinae plane (esp) block versus infraclavicular subomohyoid (iso) block in the provision of efficacy of either technique in postoperative analgesia in shoulder surgery, aiming to testing the safety of each block in terms of incidence of complications. patients will be randomly divided into two groups, group e will receive erector spinae block and group i will receive infraclavicular subomohyioid block. the local anesthetic solution that will be used in both blocks will be a total volume of 30 mls 0.25%bupivacaine plus 3mg preservative free dexamethasone. the time between recovery from anesthesia and first pain experienced, as verified by nrs ≥ 3 and first need of a rescue analgesic, will be defined as the duration of analgesia. the total dose of intravenous morphine (the rescue analgesic) used over 24 h postoperatively will be recorded.


Eligibility criteria:
inclusion criteria: * adult patients, above 18 years old. * asa physical status i * scheduled for shoulder surgery exclusion criteria: * morbid obese. * previous surgery in the same shoulder. * history of psychiatric disorder. * pulmonary disease. * contraindication to regional nerve block (e.g. skin infection at the puncture site, coagulopathy). * allergy to any of medications that will be used

Keywords: erector spinae plane block infraclavicular subomohyoid block shoulder surgery
telecommunications system in sleep apnea

Conditions: Sleep Apnea, Obstructive

Summary: this study is investigating the effects of a telecommunications system designed to improve patient adherence with prescribed positive airway pressure (cpap).

background/rationale: obstructive sleep apnea syndrome (osas) is an important chronic disease of adults, affecting an estimated 4% of men and 2% of women in the united states. nasal continuous positive airway pressure (cpap) has been demonstrated to ameliorate the symptoms and neurobehavioral consequences of osas. unfortunately, patient adherence with prescribed cpap is low, diminishing the benefits obtained from this expensive therapy. nurse-administered patient education and monitoring of cpap use through home visits has been shown to be effective in significantly improving cpap adherence. given the logistic complexity of delivering this service and its costs, it is unlikely to be disseminated widely into clinical practice. an alternative, using advanced telecommunications technology to deliver similar adherence improvement services, is proposed for study. objective(s): use of telecommunications systems with other important health-related behaviors such as medication-taking, diet, and exercise have demonstrated significant improvements in therapy adherence. methods: this research project represents a randomized controlled trial of a telephone-linked communications (tlc) system designed to improve cpap adherence (tlc-cpap). the study will enroll adults with osas who are being started on nasal cpap therapy. subjects will be randomized to tlc-cpap or an attention placebo control group. the effect of tlc on cpap use and on disease-specific quality of life (qol), osas-related symptoms, depression, and vigilance over a 12-month interval will be assessed. the intervention and control groups will be compared to assess differences in potential confounders including age, sex, osas severity, cpap pressure level, comorbid illness, physician specialty status, bmi, socioeconomic status, and marital status. each of the outcome variables (all of which are continuous variables) will be compared between intervention and control groups using multivariate analyses to adjust for any potential confounders that differ between groups. multivariate models will include appropriate tests of interactions. all analyses will be performed using an intent-to-treat approach. status: completed impact: this telephone-linked communications (tlc) technology offers an effective, low-cost, and easy-to-use means of providing disease-specific education, monitoring, and counseling to improve adherence with therapy.

Eligibility criteria:
inclusion criteria: * physician diagnosis of obstructive sleep apnea syndrome plus polysomnography demonstrating greater than 10 apneas plus hypopneas per hour of sleep * age 18-80 years * ability to use a telephone without assistance exclusion criteria: n/a

Keywords: sleep apnea, obstructive quality of life depression patient compliance
growth hormone treatment of children diagnosed of intrauterine growth retardation

Conditions: Foetal Growth Problem; Small for Gestational Age

Summary: this trial is conducted in europe. the aim of this trial is to assess and compare the efficacy and safety of two dose levels of somatropin over a long period (till final height is reached). this trial is an extension to trials ghretard/bdp/14/nl (a 2-year initial trial) and ghretard/bpd/20/nl (a 2-year extension trial).


Eligibility criteria:
inclusion criteria: * completion of the ghretard/bpd/20/nl trial * written informed consent from child and/or parents/guardians before continuation in the extension trial
feasibility of a music therapy intervention to decrease stress during pediatric critical care

Conditions: Critical Illness; Hypoxia, Brain

Summary: admission into a pediatric intensive care unit (picu) is a highly stressful experience for child and family. high levels of stress can negatively impact outcomes, yet non-pharmacological interventions to decrease stress in the picu are severely lacking. this is a prospective, single-arm feasibility trial that will explore the feasibility and acceptability of a music therapy intervention to decrease stress in the picu among families of children receiving invasive or noninvasive mechanical ventilation. objectives: the aims of this study are to: 1) assess the feasibility of implementing a music therapy intervention in the picu among children receiving invasive or non-invasive mechanical ventilation; 2) determine the acceptability of the music therapy intervention in the icu among caregivers, patients, and pediatric and cardiac icu staff; 3) explore the variability in child and caregiver stress outcomes throughout icu admission. hypothesis: the music therapy intervention will be feasible, as determined by recruitment, retention, protocol adherence, and data collection rates, and will be acceptable to participants and to picu staff. sample: this study will recruit 20 families that include children aged 2 months - 17 years old admitted with an expected length of icu stay greater than 72 hours. of these 20 families, the investigators will specifically recruit 10 families whose child is admitted for a hypoxic brain injury. eligible children are receiving either noninvasive mechanical ventilation (i.e., continuous or bilevel positive airway pressure), invasive mechanical ventilation, or have an established tracheostomy tube and with escalated support settings. one primary caregiver will be enrolled along with the child admitted into the icu.


Eligibility criteria:
inclusion criteria: * parent/caregiver aged 18 years or older. * children aged 2 months - 17 years admitted to the picu with an expected length of stay greater than 72 hours * child is receiving either noninvasive mechanical ventilation (i.e., continuous or bilevel positive airway pressure), invasive mechanical ventilation, or have an established tracheostomy tube and with escalated support setting exclusion criteria: * the legal guardian is unclear, * caregiver does not read, write, and speak english * child is not expected to survive that picu stay or has care limitations in place * child has deafness in both ears, in foster care or justice system, or experiences musicogenic epilepsy.
a phase ⅱ study of xelox chemotherapy with or without surgery of primary lesion for colon cancer patients

Conditions: Metastatic Colon Cancer

Summary: the primary endpoint is to evaluate the tfs (time to failure of strategy).

the primary endpoint is to evaluate the time to failure of strategy, that is the second progression time after induction therapy by the use of xelox regimen, comparing xelox regimen chemotherapy combined with or without surgical resection of the primary lesion from the time of randomization to maintenance therapy and reapplication of induction therapy, or time to the use of second line strategy (if no reapplication of induction therapy) or time to no further treatment.

Eligibility criteria:
inclusion criteria: 1. 18\~75 ears old 2. pathological diagnosis of colon cancer adenocarcinoma 3. no systemic chemotherapy for metastatic tumors 4. ecog (eastern cooperative oncology group) 0-1 and expected survival period for 6 months or more 5. at least one measurable objective tumor lesions 6. anc≥1.5\*109/l；plt≥90\*109/l；hb≥90g/l；tbi≤1.5(unl); alt、ast≤2.5uln；cr≤1.0(uln) screening within 7 days 7. primary and metastatic tumors exist at the same time, and distant metastases are not resectable 8. patients with voluntary participation, and sign the informed consent exclusion criteria: 1. operation intervention required for perforation, bleeding and obstruction of intestinal cavity 2. with uncontrollable large pleural or peritoneal effusion 3. alcohol or drug addictions 4. malignant tumour of the past five years with other organizations to source, but the full treatment of cervical carcinoma in situ and except skin basal cell carcinoma and squamous cell carcinomas 5. with brain metastasis 6. multiple primary colorectal carcinoma 7. pregnancy or breast-feeding women 8. there is an important organ failure or other serious diseases, including coronary artery disease, symptomatic cardiovascular disease or myocardial infarction within 12 months; serious neurological or psychiatric history; severe infection; actively disseminated vascula blood coagulation.

Keywords: tfs (time to failure of strategy)
increasing primary care physician colorectal cancer screening rates

Conditions: Colorectal Cancer Screening

Summary: the purpose of the study is to determine if a web-based intervention increases physician rates of colorectal cancer recommendation rates in a group of physicians participating in the american board of internal medicine's maintenance of certification program. this study will also compare the content of practice improvement plans submitted by the diplomats in each study arm to determine the components of the plans that are associated with colorectal cancer rates.

colorectal cancer is the 2nd leading cause of cancer deaths in the u.s. although colorectal cancer screening (crcs) is effective, cost-effective and consistently recommended by clinical practice guidelines, only 57.3% of the adults over 50 years have been screened within the recommended interval. preliminary research conducted by this pi demonstrates that approximately 90% of patients who have not had crcs report that a doctors recommendation would motivate them to undergo screening. however, research also shows that physicians do not consistently recommend crcs to each eligible patient. in this study the barriers of and facilitators to physician recommendation of crcs are tested in the to proposed randomized controlled trial. the trial will pilot test an interactive, multifaceted, web-based intervention (etoolbox) to increase primary care physician rates of crcs. this application innovatively proposes to pilot test the etoolbox in the setting of the american board of internal medicine (abim) maintenance of certification process within the preventive services practice improvement module, a physician-directed measurement of their performance and quality improvement requirement for board re-certification.

Eligibility criteria:
inclusion criteria: * abim certification and have or plan to enroll in the maintenance of certification program * primary care physicians exclusion criteria: * diplomats are not able to participate in this study if they are retired physicians, do not practice a primary care practice or who have already taken part in the study

Keywords: colorectal cancer screening american board of internal medicine maintenance of certification program currently enrolled in or plan to enroll in the american board of internal medicine maintenance of certification program