Kornimate/medical-research-clean huggingface dataset:
fear of recurrence and stopping immunotherapy

Conditions: Cognitive Behavioral Therapy

Summary: the study includes participants experiencing distress with regard to stopping immunotherapy and will utilize cognitive-behavioral therapy to reduce fear of recurrence, depression, and anxiety and improve quality of life.

the intervention will be delivered through telemedicine to reduce the patient-related barriers to treatment including cost, transportation, and being able to maintain appointments while managing the side effects of treatment. the intervention will provide the patient with skills to reduce distress associated with ceasing treatment of a checkpoint inhibitor through the development evidence-based psychological and behavioral strategies that are tailored to the patients' preferences.

Eligibility criteria:
inclusion criteria: * age 21 years and older * fluent in english * diagnosis of cancer and history of treatment with immunotherapy exclusion criteria: * active suicidal ideation, delusions or hallucinations

Keywords: fear of recurrence quality of life depression anxiety
patients reactions towards their diagnosis as having covid-19

Conditions: Covid19

Summary: patients reactions towards their diagnosis as having covid-19. the effect of patients' reaction toward their prospect management. how this can make many hazards. also, obstacle and barrier to better management.

patients reactions towards their diagnosis as having covid-19. the effect of patients' reaction toward their prospect management. how this can make many hazards. also, obstacle and barrier to better management. different factors affecting the response of people toward their diagnosis as covid-19

Eligibility criteria:
inclusion criteria: * covid-19 * age 18 years of less exclusion criteria: * mental diseases making the communication with them difficult
modulation of lung injury complicating lung resection

Conditions: Acute Lung Injury

Summary: the purpose of this study is to determine whether n-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.

acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. management of these patients is largely supportive. even in patients who do not develop clinical evidence of acute lung injury, markers of inflammation and oxidative stress are present in blood and exhaled breath condensate after lung resection. the purpose of this randomised double-blind placebo-controlled study is to determine whether lung injury can be prevented by pre-administration of n-acetylcysteine.

Eligibility criteria:
inclusion criteria: * elective lung resection for cancer exclusion criteria: * age less than 18 years * women of child-bearing age or potential * known allergy to n-acetylcysteine * oral steroid in the preceding 1 month * n-acetylcysteine in the preceding 1 month * unable to receive standardised anaesthetic approach

Keywords: acute lung injury lung resection
effectiveness of a nurse facilitated face care group in patients with schizophrenia

Conditions: Body Image

Summary: this study aims to explore the effectiveness of nurse-facilitated face care group on body image and self-esteem in female patients with schizophrenia.

many studies have shown that patients with schizophrenia have poor cleanliness and negligible appearance, which leads to negative body image and low self-esteem. however, there are few researches in taiwan that nurse facilitated face care group in patients with schizophrenia to improve their body image and self-esteem.this study was to explore the effectiveness of a nurse facilitated face care group in patients with schizophrenia in improving their body image and self-esteem.a total of 96 patients with schizophrenia in a mental hospital in southern taiwan were recruited in this study. the participants were divided into experimental and control groups through block randomization. in addition to participating in routine functional treatment activities, the experimental group is required to receive an additional 50 minutes of face care grou every two weeks led by the nurse. the patients in control group received routine functional treatment activities, a facial cleansing instruction and five facial cleansing videos. the research tools include demographic data, the subscale in mbsrq - appearance evaluation and appearance orientation, face-q - appearance-related psychosocial distress. face-q - satisfaction with outcome. face-q - psychological function. face-q - satisfaction with skin. face-q - social function. rosenberg self-esteem scale (rses). a questionnaire survey of body image and self-esteem was conducted before the intervention, 12 weeks after the intervention and one month after the end of the intervention.the collected data were analyzed by ibm spss 24.0 statistical software. the descriptive statistics include mean, minimum, maximum, standard deviation, frequency distribution, and percentages; the generalized estimating equation (gee) were employed to explore the effectiveness of a nurse facilitated face care group in patients with schizophrenia after controlling demographic data.

Eligibility criteria:
inclusion criteria: * people with schizophrenia and schizoaffective disorder for more than two years. * the age is above 20 year. * can communicate with mandarin or taiwanese. * the score of the positive and negative syndrome scale(panss) is below 60(included). * people are willing to participate in this study, can read and know the consent and can sign on the consent by their own. exclusion criteria: * exclude people with a personality disorder, brain injury, cognitive impairment, intellectual developmental disorder or substance use disorder. * people who are not willing to sign the consent. * people can not read. * people can not communicate with mandarin or taiwanese.
pancreatic quantitative sensory testing (p-qst) to predict treatment response for pain in chronic pancreatitis

Conditions: Chronic Pancreatitis; Chronic Pain

Summary: abdominal pain in chronic pancreatitis (cp) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. the proposed clinical trial will evaluate the predictive capability of pancreatic quantitative sensory testing (p-qst) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with cp who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

p-qst has been shown to be able to phenotype patients with cp into nociceptive patterns according to degree of central sensitization. as a tool to identify baseline nociceptive pattern in patients with painful cp, p-qst will be performed at baseline prior to planned invasive treatment with endoscopic therapy or decompressive surgery. we will evaluate the ability of p-qst to predict response to invasive treatment for painful cp, and to develop a predictive model for individualized prediction of treatment response. patients will undergo pre-procedure p-qst testing before undergoing scheduled invasive treatment as directed by their treating gastroenterologist. the date of first endoscopic therapy or surgery will be used to calculate follow-up timepoints, which will be scheduled at 3, 6, and 12 months after the first endotherapy session or surgery. at each follow-up time point, patients will answer questions about their pain. in addition, patients will complete patient reported outcome tools (hads, pcs instruments) and the patient global impression of change. serum and urine samples will be obtained at baseline and at 6-month follow-up timepoints.

Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years of age with definite cp undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain. * endoscopic therapy: endoscopic retrograde cholangiopancreatography (ercp) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or extracorporeal shock wave lithotripsy (eswl). * surgery: drainage procedures (frey and puestow operations) exclusion criteria: * patients with chronic pain from conditions other than cp * patients \< 18 years of age * patients who have had endoscopic therapy within the past 12 months * patients who have undergone prior pancreatic surgery * patients who have resective surgical procedure planned (eg. whipple procedure, total pancreatectomy) * patients with peripheral sensory deficits * patients with known pregnancy at the time of study screening\*\* * note: women who become pregnant during the course of the study can no longer participate in p-qst testing.

Keywords: chronic pain chronic pancreatitis recurrent acute pancreatitis chronic abdominal pain ercp pancreatic surgery
effects of exercise on cervical pain through educational videos

Conditions: Neck Pain

Summary: due to the increased prevalence of neck pain in studied adolescents and young adults, this intervention is carried out, which mainly seeks to compare and verify the effectiveness of therapeutic exercise with education, compared to education alone. it is also necessary to mention the high levels of stress levels reported in students, which can affect the increase in pain and the perception of these at times when stress increases. the intervention has been decreed in the weeks before and during the exam period at the university of valencia, to see if the neck pain experienced by students at similar stages of their academic life is prevented or reduced. it is decided to use education above all to give the participants a tool that allows the participants to find out what happens and why it happens when the participants suffer from neck pain, as well as an explanation of the pathology and the risk factors and how to avoid -the bear. in addition, knowledge about the condition in question can lead to a reconceptualization of pain, changing the approach and exposing a different approach, when treating the pathology. it must be said that in the structure and layout of the informative document, the investigators think of an instrument that can serve the participants for the future. another reason for carrying out the study is the few tests on neck pain carried out with new technologies. the use of videos, therefore, seeks to facilitate access to the information provided, being a useful and practical tool for students, familiar with the use of new technologies. in addition, the training is intended to be as didactic as possible, the chosen exercises are carefully explained and the fact that they are found in videos and not in a practical class, favors access to the content in these, for that the participants use the videos at their disposal. finally, treating neck pain with training and education and taking into account the stress of students, brings to conventional treatment an interesting perspective of coping, focused on the biopsychosocial field.


Eligibility criteria:
inclusion criteria: * students of first curse of physiotherapy. * that they have had an episode of neck pain at exam time. exclusion criteria: * they do not want to sign the informed consent. * that they present some pathology that causes chronic cervical pain.

Keywords: video pills exercise neck pain
breaking the bad news to the bereaved family and their reactions

Conditions: The Effective Factors on the Grief Reactions to the Death Information

Summary: the demographic characteristics, satisfaction survey evaluations and emotional reactions of the relatives of the patients who are admitted to the intensive care unit and who have an expected mortality rate higher than 50% according to the apache-2 scoring system will be investigated.

patients with an apache-2 score\> 25 (expected mortality rate\> 50%) during the first 24 hours of hospitalization in the intensive care unit will be included in the study. a person who comes to the most frequent visit from relatives of patients will be included in the study. demographic data of the relative of the patient after the informed volunteer consent form has been approved (age, proximity, educational background, patient co-existence, ethnicity, marital status, number of children, history of psychological treatment and the presence of an intensive care treatment history of any family member before) will be registered. after the 3rd, 10th, and 30th days of patient admission, and once a month, the patient satisfaction survey will be filled face to face during informing the patient's relative. in this patient group with an expected mortality of\> 50%, if death occurs, the information will be made to the visitor of the patient who frequently visits the patient and agrees to participate in the study. the emotional reaction of the relative of the patient participating in the study during the declaration of death will be recorded in the case report form. grief reaction is unique, and it will differ from one individual to another. possible reactions of relatives of patients during the death notification (emotional reactions) 1. regular response; in this case, the relatives of the patients often describe the event as expected or my patient is now free from suffering. 2. initial shock reaction; it may be complete desperation and a state of closure, 3. denial- this is an initial defense mechanism after the unexpected, devastating news, and it should be recognized and tolerated. acceptance may be possible by encouraging the relatives to view the body of the deceased, especially to those relatives who were not present at the time of death 4. anger- this is a common reaction after the sudden death of a beloved relative. the expression of this anger can vary from mild irritation to violent behavior. this can be expressed on self, hospital staff, or any other person. anger will gradually diminish once expressed 5. guilt- this is nothing but the inward expression of anger and self-blame. consoling words of the health care team will help to do away with this emotion.

Eligibility criteria:
inclusion criteria: * apache 2 score\> 25 or expected death rate\> 50%, * hospitalization period\> 72 hours in intensive care unit - exclusion criteria: * apache 2 score \<25 or expected death rate \<50%, * those who have a stay in icu \<72 hours * currently receiving psychological medication * those who do not accept one of the legal heirs to participate in the study

Keywords: patient death , grief reactions
comparing radiological tubal blockage versus laparoscopic salpingectomy in infertile women with hydrosalpinx during in vitro fertilization treatment

Conditions: IVF-ET; Hydrosalpinx

Summary: hydrosalpinx (hx) has a detrimental effect on the rates of implantation, pregnancy, live delivery, and early pregnancy loss during in vitro fertilization (ivf). the effectiveness of radiological tubal blockage has not been compared with the standard treatment of laparoscopic salpingectomy in randomized trials. the investigators aim in this randomized trial to compare the live birth rate of radiological tubal blockage versus laparoscopic salpingectomy in infertility women with hx prior to frozen-thawed embryo transfer (fet). eligible women will be recruited and randomized into one of the following two groups: (1) the radiological tubal blockage group and (2) the laparoscopic salpingectomy group. the primary outcome is the live birth rate.


Eligibility criteria:
inclusion criteria: * women aged 20-43 years at the time of ivf/icsi treatment * unilateral or bilateral hx visible on pelvic ultrasound or hysterosalpingogram * at least one frozen embryo or blastocyst available for transfer exclusion criteria: * a history of pelvic inflammatory disease within 6 months * hx that were already blocked proximally on hysterosalpingogram * frozen pelvis from previous laparoscopy * women with fibroids interfering with radiological tubal blockage * undergoing preimplantation genetic testing
vascular endothelial growth factor (vegf) & loc387715/htra1 polymorphism in polypoidal choroidal vasculopathy

Conditions: Age-Related Macular Degeneration

Summary: this study is to investigate whether there is an association of the loc387715/htra1 and vascular endothelial growth factor polymorphism with response to treatment with intravitreal ranibizumab injections for patients with polypoidal choroidal vasculopathy.

this is a retrospective comparative case series comprised of 70 patients being treated for polypoidal choroidal vasculopathy with intravitreal ranibizumab injections and 112 control subjects. patients were genotyped for the loc387715 (rs10490924), htra1 gene (rs11200638), and vegf (rs3025039 and rs833069)polymorphism using real-time polymerase chain reaction.

Eligibility criteria:
inclusion criteria: * patients older than 60 years of age at onset * polyp-like terminal aneurysmal dilations with or without branching vascular networks in icga and subretinal reddish-orange protrusions corresponding to polyp-like lesions * patients who had intravitreal injections of 0.5 mg of ranibizumab monthly for 3 months exclusion criteria: * patients with retinal or choroidal diseases including pathologic myopia, angioid streaks, idiopathic choroidal neovascularization (cnv), presumed ocular histoplasmosis, and other secondary cnv * patients who refused genotypic analyses
diagnostic rentability of screening for associated conditions in calcium pyrophosphate deposition disease patients

Conditions: Chondrocalcinosis

Summary: the purpose of this study is to determine whether thorough analytical evaluation is useful to diagnose metabolic conditions associated to calcium pyrophosphate deposition disease.

the diagnostic usefulness of screening for hyperparathyroidism, hemochromatosis, hypothyroidism and hypophosphatasia in patients diagnosed with calcium pyrophosphate dihydrate (cppd) deposition disease is uncertain. patients diagnosed with cppd deposition disease were compared to patients with rheumatoid arthritis and psoriatic arthritis over a 9-year period. all patients were prospectively followed for at least 12 months. serum calcium, phosphorus, alkaline phosphatase, thyroid-stimulating hormone, ferritin, iron, and total iron binding capacity were determined in all patients.

Eligibility criteria:
inclusion criteria: * patients diagnosed as having calcium pyrophosphate dihydrate deposition disease. exclusion criteria: * patients mimicking a rheumatoid arthritis disease, with positive rheumatoid factor or with psoriasis.

Keywords: calcium pyrophosphate associated conditions
covadial - immunogenicity of covid-19 vaccine in hemodialysis patients

Conditions: Covid19

Summary: covid-19 is a severe disease with poor prognosis in patients receiving in-center haemodialysis (hd). a population-based registry of \>4,000 patients with a diagnosis of covid-19 receiving kidney replacement therapy (either haemodialysis or kidney transplant recipient) highlighted a 21.1 fold higher 28-day mortality risk among patients on dialysis (n = 3,285), than the expected 1.2% mortality of propensity-score matched historical controls. vulnerability in uraemic patients is a combination of intrinsic frailty, increased risk of infection and a high burden of comorbidities. in patients on hd, abnormalities in the immune response may contribute to relative hyporesponsiveness to vaccines. however, patients on hd appear to seroconvert at a similar rate compared to the general population after sars-cov-2 infection, suggesting a likelihood of vaccine efficacy but this population has been excluded from vaccine trials. the primary aim of this study is to evaluate antibody synthesis induced after covid-19 vaccination in a french adult multicentric cohort of in-center haemodialysis patients. the second aim of this study is to identify vaccine non-responders among hd patients and to assess the clinical and biological risk factors associated with non-response.

hemodialysis patients were excluded from covid19 vaccine response studies: seroprotection rate? long-term protection? different regimens to offer to hemodialysis patients?

Eligibility criteria:
inclusion criteria: * all in-center haemodialysis individuals eligible and voluntary to receive one of the approved covid-19 vaccines. exclusion criteria: * individuals under 18 years of age

Keywords: covid19 vaccine response serology haemodialysis
3d echocardiography and cardiovascular prognosis in mitral regurgitation

Conditions: Mitral Regurgitation

Summary: the 3d-prime study will analyse whether use of 3d echocardiography can improve risk stratification and cardiovascular outcome in patients with mitral regurgitation of different etiologies.


Eligibility criteria:
inclusion criteria: * adult patients with primary or secondary mitral regurgitation (mr) * mr of moderate or severe degree * 3d echocardiographic examinations of \>= good spatial and temporal resolution exclusion criteria: * co-existence of another valve disease of severe degree * inability to give informed consent
coping skills treatment for smoking cessation

Conditions: Nicotine Dependence

Summary: the primary purpose of this study is to evaluate the efficacy of a new type of exposure- and acceptance-based smoking cessation treatment vs. standard behavioral smoking cessation treatment, in conjunction with the use of the transdermal nicotine patch. in both treatments, participants will receive one 60-minute individual session, seven 2-hour group sessions and two individual brief telephone contacts over an eight-week period. both treatments include 8 weeks of transdermal nicotine patch, which will begin at the time of quitting smoking and will continue after the treatment sessions have ended. participants will provide follow-up data with regard to their smoking status through a one-year follow-up period.

1. 18-65 years of age, 2. a regular smoker for at least one year, 3. currently smoking 10 or more cigarettes per day, 4. report motivation to quit smoking in the next month.

Eligibility criteria:
inclusion criteria: * 18-65 years old * regular smoker for at least one year * currently smoking 10 or more cigarettes per day exclusion criteria: * current axis i disorder * psychoactive substance abuse or dependence (excluding nicotine dependence) within past year * current suicidal risk * pregnancy or breast feeding * use of nicotine replacement products or bupropion

Keywords: cigarette smoking smoking cessation nicotine dependence