Kornimate/medical-research-clean huggingface dataset:
role of senescence in the development of endometrial cancer

Conditions: Endometrial Hyperplasia and Endometrial Cancers

Summary: several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q. several genes of interest have been identified (p53, pten, pik3ca, ß-catenin, k-ras ...). a study has already been carried out at the reims university hospital with inclusion of patients with endometrial cancer and patients with endometrial hyperplasia. it identified specific alterations of nosologic continuum of pathology and characterize areas of interest on the genome.

make a pangenomic investigation of genetic abnormalities in atypical endometrial hyperplasia and endometrial cancers.

Eligibility criteria:
inclusion criteria: * patient with endometrial hyperplasia or endometrial cancer * patient consenting to participate to the study * patient enrolled in the national healthcare insurance program * patient older than 18 years exclusion criteria: - patient with neoadjuvant chemotherapy or radiotherapy prior to surgery
bunionectomy trial with grt6005

Conditions: Post Operative Pain

Summary: the purpose of the trial is to determine whether the new centrally acting analgesic is effective in comparison to placebo and an active comparator (morphine).


Eligibility criteria:
inclusion criteria: * subjects scheduled to undergo primary unilateral first metatarsal bunionectomy exclusion criteria: * contraindications to, or history of allergy or hypersensitivity to morphine, fentanyl, hydrocodone, acetaminophen, heparin, polyethylene glycol 400 usp-nf or any compound planned to be used during the anesthesia, or their excipients. * concomitant inflammatory disease. * life-long history of seizure disorder or epilepsy. * subjects with impaired renal function * subjects with impaired hepatic function * female subjects who are pregnant or breastfeeding. * resting pulse rate is \ 100 bpm after 5 minutes rest in supine position * resting blood pressure after 5 minutes rest in supine position: systolic blood pressure is \ 140 mmhg diastolic blood pressure is \ 90 mmhg

Keywords: analgesic bunionectomy surgery post operative pain single hallux valgus repair
mindful meditation for epidural catheter placement

Conditions: Anxiety; Pain

Summary: given the high prevalence of neuraxial analgesia use during labor and the anxiety associated with these procedures, a method to decrease this anxiety could benefit millions of laboring women each year. mindfulness practice has been used by many groups to decrease anxiety during pregnancy with optimistic results. however, there has been no major study evaluating the role of mindfulness interventions on anxiety associated with neuraxial placement. the purpose of our study is to address this gap in knowledge.

the primary objective of this study is to evaluate the effects of a brief mindful meditation intervention on anxiety and satisfaction regarding epidural catheter placement for laboring parturients.the investigators hypothesize that a brief mindful meditation intervention, consisting of a 10 minute auditory instructional practice, implemented before epidural catheter placement will: 1. decrease anxiety 2. increase satisfaction compared to a neutral 10 minute auditory recording control, in participants undergoing labor epidural catheter placement. the secondary objective of this study is to evaluate whether anesthesia providers experience a difference in satisfaction with labor epidural catheter placement in participants who listen to a brief mindful meditation intervention prior to epidural catheter placement. the investigators hypothesize that anesthesia providers placing labor epidural catheters in patients who listen to a brief mindful meditation intervention prior to labor epidural catheter placement will: 1. experience an increase in satisfaction with labor epidural catheter placement.

Eligibility criteria:
inclusion criteria: * patients are eligible for enrollment if they are greater than 18 years of age, admitted for vaginal delivery, anticipating epidural analgesia, and report a numerical pain scale rating of 3 or less at the time of enrollment. exclusion criteria: * do not speak english or admitted for cesarean delivery will be excluded from the study
herombopag added to cyclosporine in non severe aplastic anemia

Conditions: Non Severe Aplastic Anemia; Untreated

Summary: this is a prospective, multicenter, single-arm, phase 2 trial. the aim of this study is to evaluate the efficacy and safety of herombopag combined with cyclosporine for patients with non severe aplastic anemia (nsaa).

this study aims to improve the 24 weeks response rate. the sample size is calculated based on simon's two-stage design. the first stage of the study enrolled a cohort of 15 patients. if after 24 weeks at least 9 patients achieved a response, then enrollment was expanded to a total of 43 patients. the null hypothesis was unaccepted if more than 26 of 43 patients achieved the response. accounting for a 20% dropout rate, the estimated final sample size was 54 patients.

Eligibility criteria:
inclusion criteria: * willing and able to comply with the requirements for this study and written informed consent. * male or female age ≥ 18 years * diagnosis of untreated non severe aplastic anemia. * platelet counts \< 50 x 10\^9/l at least 2 times consecutively (time interval ≥ 1 week) exclusion criteria: * receive immunosuppressive therapy more than 4 weeks before enrollment * treatment with tpo-ra within 1 week before enrollment * inherited bone marrow failure syndromes * bone marrow fibrosis grade ≥ 2 * the presence of hemolytic pnh clone * the presence of clonal karyotypic abnormalities (del(20q), +8 and -y are not included in this category) * previously treated with tpo-ra ≥ 4 weeks * previously received immunosuppressive therapy ≥ 12 weeks * ferritin \> 1000 ng/ml (the increased level of ferritin led by infection is not included in this category) * have an allergy to eltrombopag or any other part of this medicine. * history of radiotherapy and chemotherapy for malignant solid tumors * cytopenia caused by other non-hematologic diseases, including liver cirrhosis, active rheumatic connective tissue disease, and persistence of infectious diseases, etc * abnormal liver function: alt or ast \> 3 uln, or tbil \> 1.5 uln after treatment. * abnormal kidney function: creatinine clearance \ 1.5 uln * patients with diabetic nephropathy, neuropathy, or eye disease * patients with poorly controlled hypertension or cardiac arrhythmia * patients with congestive heart failure and the nyha grade ≥ 3 historically or currently, and lvef \< 45% within 4 weeks before enrollment * history of arteriovenous thrombosis within 1 year before enrollment * participation in another clinical trial within 4 months before the start of this trial * pregnant or breast-feeding patients * patients considered to be ineligible for the study by the investigator for reasons other than the above
efficacy of vit e in pcos resistant to clomiphene citrate

Conditions: Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Summary: this study evaluate the addition of vit e to clomiphene citrate in the treatment of poly cystic ovary.half the patients will receive both vit e and clomiphene citrate the other half will receive clomiphene citrate only.

clomiphene and vit e each used in treatment of pco but they do so by different mechanisms. clomifene is in the selective estrogen receptor modulator (serm) family of medication. it works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary. vit e is used in treatment of pco due its anti-oxidant effect.

Eligibility criteria:
inclusion criteria: 1. patients will be diagnosed as having pcos according to the rotterdam criteria for diagnosis of pcos 2. age between 18 and 39 years. 3. period of infertility \>1 years. 4. no treatment taken during the last 2 months. 5. patients who have previously received clomiphene citrate (cc) and being diagnosed as having cc resistance exclusion criteria: 1. history of pelvic surgery or infertility factor other than anovulation 2. endocrine disorders in the form of hypothyroidism or hyperthyroidism, hyperprolactinemia, and cushing syndrome, as detected by history, examination, or investigations. 3. known cases of endometriosis (approved histologically), uterine anomaly or hydrosalpinx, retinitis pigmentosa and vitamin k deficiency. 4. consumption of vitamin and antioxidant supplementations in the last three-months before the trial start date. 5. male factor infertility (sperm count \< 5 million per milliliter, normal morphology \<4%). 6. elevated serum prolactin, t.s.h and f.s.h. 7. patients diagnosed with diabetes mellitus

Keywords: vitamin e polycystic ovary
a comparative pilot study of high-order aberrations with aspheric iol models sn60wf and zcb00

Conditions: Cataracts

Summary: the purpose of this study was to prospectively compare high-order aberrations between eyes implanted with the acrysof® natural iq (sn60wf) intraocular lens (iol) versus those implanted with the tecnis zcb00 iol.


Eligibility criteria:
inclusion criteria: * requires bilateral extraction of cataracts by phacoemulsification followed by implantation of a posterior chamber intraocular lens; * confirmed absence of pre-existing conditions that could skew the results or present contraindications for the iq intraocular lens (iol) or the tecnis zcb00 iol; * \<1 diopter corneal astigmatism preoperatively; * able to achieve 6.5 mm dilated pupil; * other protocol-defined inclusion criteria may apply. exclusion criteria: * chronic disease or illness; * irregular optical aberration; * amblyopia; * history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, etc.); * diabetic retinopathy; * macular degeneration; * history of retinal detachment; * other surgeries planned at time of cataract removal; * severe dry eye; * other protocol-defined exclusion criteria may apply.

Keywords: cataracts aspheric iol ocular aberrations
cervical epidural pressure measurement

Conditions: Head Pain; Neck Pain; Upper Extremity Pain

Summary: cervical epidural steroid injections * the hanging drop (hd) technique is commonly used for identifying the cervical epidural space. * the hanging drop (hd) technique is using the negative pressure in the epidural space. * the subject of debate whether the epidural space exhibits negative pressure. * in a previous study, ep might be influenced by body position * no report or peer-reviewed literature to demonstrate the cervical epidural pressure (cep) now. the hypothesis of this study * there is a difference in the cervical epidural pressure between in the prone and sitting positions * to evaluate this hypothesis, ceps in the prone and sitting groups were measured and compared in the two groups. * using a closed pressure measurement system * under fluoroscopic guidance.

cervical epidural steroid injections (cesis) * for the conservative management of head, neck, and upper extremity pain * important to identify the epidural space for minimizing the chance of a dural puncture injection * dural puncture injection makes cesis prone to rare but catastrophic complication like permanent spinal cord injury the hanging drop (hd) technique * commonly used for identifying the cervical epidural space * using the negative pressure in the epidural space * the subject of debate whether the epidural space exhibits negative pressure in previous studies using a closed pressure measurement systems * the epidural pressure (ep) was commonly positive at the thoracic level in the lateral decubitus position. * ep was consistently negative only in the sitting position. * ep might be influenced by body position. * the patient should be sitting for using the hd technique. no report or peer-reviewed literature to demonstrate the cervical epidural pressure (cep) now. the hypothesis of this study * there is a difference in the cervical epidural pressure between in the prone and sitting positions * to evaluate this hypothesis, ceps in the prone and sitting groups were measured and compared in the two groups. * using a closed pressure measurement system * under fluoroscopic guidance.

Eligibility criteria:
inclusion criteria: * cervical radicular pain caused by herniated nucleus pulpous and spinal stenosis * other conditions including herpes zoster-associated pain and sprain. exclusion criteria: * contraindications for cesis, such as coagulopathy, patient refusal or infection at the proposed insertion site * previous cervical spinal surgery * pregnancy.

Keywords: cervical epidural epidural pressure monitoring
implications of pacifier use in israeli children

Conditions: Crossbite; Openbite; Drooling

Summary: the purpose of this study is to examine pacifier sucking habits among children, and to assess implications of the oral habit - for example malocclusions and drooling. the effect of pacifier sucking will be recorded and compared to pacifier type and frequency of use.

pacifier study protocol * the study will take place in children day care centers in jerusalem and "hasharon" area. * first step = receiving an approval from the children's parents and the day care management for the research. * next step = examine a total of 400 children who use a pacifier, with a dental mirror in regular lighting condition. * the procedure is short, no need of repetition or tracing and without any side effects or discomfort. part 1- a short questionnaire of demographic background- will be answered by the parents: 1. personal details- parents names and ages, child's name and id number, relation to the child (mother, father...) 2. social economic status - mother's education, place of residence, number of children in the family. 3. child's personal details -gender, age, number of siblings 4. pacifier use habits- period of use, type of pacifier, frequency of use, reason of using a pacifier. 5. child's dental condition- drooling, cross bite, open bite. 6. parents' awareness of pacifier's effect on mouth development. 7. parents' approval for child examination. part 2- clinical- visual examination for identification of relevant findings 1. child's pacifier type. 2. dental clinical examination performed in a lightened room: * diagnosis of caries- data will be written in a chart. * diagnosis of malocclusion- open bite or cross bite 3. diagnosis of drooling from mouth corners which indicates malocclusion. redness or dryness around lips and chin can imply drooling.

Eligibility criteria:
inclusion criteria: * healthy children aged 3-4 years that use a pacifier exclusion criteria: children suffering from a chronic or developmental disease that can affect the orofacial region * finger sucking children children suffering from low muscle tonus, abnormal drooling

Keywords: pacifier sucking children occlusion drooling
study comparing total extraperitoneal patch "tep" versus lichtenstein according chronic pain

Conditions: Chronic Pain; Sexual Dysfunction

Summary: the purpose of this study is to se if there is a difference regarding chronic pain and sexual dysfunction one and tree years after laparoscopic un fixated preperitoneal mesh versus gold standard open fixated on lay mesh in inguinal hernia surgery. long term cross-sectional follow-up comparing different instruments for measurement of chronic pain.

prospective randomized study comparing total extraperitoneal patch tep versus open onlay mesh according to lichtenstein in primary unilateral inguinal hernias in men between 30 to 75 years of age. non fixated polypropylene mesh is used in the tep operation and fixated light weight polypropylene mesh is used in the lichtenstein procedure. the aim is to study chronical pain and sexual dysfunction. clinical examination according nerve function, hernia status and genital findings are performed together with a questionnaire including sf36, inguinal pain questionnaire(ipq), sexual function are registered preoperatively, one and tree years postoperatively. cross-sectional follow-up in median 7.5 years using enquiries for comparison of different pain instruments to evaluate the effect of chronic pain on physical activity.

Eligibility criteria:
inclusion criteria: * men between 30-75 years of age * asa class i-ii * primary unilateral inguinal hernia exclusion criteria: * lower midline incision below linea arcuate * large scrotal hernia * previously or current abuse,mental disease * obesity bmi \> 35 * another simultaneous operation * nonreducible hernia * severe pain in the groin without nonrelated to hernia * contraindications to general anesthesia * need of language translator * liver cirrhosis or ascites * spread cancer disease * previously irradiation in the area * lack of operations indication

Keywords: inguinal hernia tep lichtenstein mesh randomized chronic pain sexual dysfunction
comparison of the rate of preoperative haemoglobin after administration of epoetin alpha associated with an oral medical supplementation versus intravenous before surgery of craniosynostosis at the child

Conditions: Craniosynostosis

Summary: oral iron is commonly used in conjunction with epo preoperatively for hemorrhagic surgeries in children and especially in the surgery of craniosynostosis. the bioavailability of oral iron is low and compliance with treatment is inconsistent. the aim of this study is to evaluate whether the use of ferric carboxymaltose by injection, which has a much better bioavailability, would make it possible to increase the preoperative hemoglobin level more effectively and thus reduce the risk of perioperative blood transfusion .

prospective study, randomized in two parallel groups (martial treatment versus venous injection) and stratified by center (montpellier, nice, angers). the number of subjects required is 100 patients, or 50 per group.

Eligibility criteria:
inclusion criteria: * craniosynostosis surgery * age: between 4 and 24 months inclusive * weight: less than 12kg * hemoglobin: 10 g / dl ≤ hb 14 ≤ g / dl * affiliated patients or beneficiaries of a social security scheme * signature of the consent of the patient's parents exclusion criteria: * generalized infection * time for consultation of anesthesia with respect to the date of surgery greater than 5 weeks or less than 22 days. * initial biological assessment dating more than 3 months before the consultation of anesthesia * parents do not understand french * bmi greater than 20 kg.m-2 * contraindications to epo * contraindications to ferric carboxymaltose and to ferrous fumarate

Keywords: craniosynostosis hemoglobin iron peros iron intravenous
the effect of probiotics on obesity. metabolic endotoxemia and inflammation

Conditions: Metabolic Syndrome

Summary: in spite of the growing evidence for the beneficial effects of probiotics, their anti-obesity effects are not well examined. no previous studies were conducted in this research area in the uae. hence, the aims of this study are to 1) investigate the link between metabolic derangements associated with obesity and levels of lps and lbp; 2) study the relatedness of low grade inflammation with the me; 3) investigate the food intake assessment; and 4) investigate the effectiveness of probiotics supplement on the obesity, me and inflammation. this project will have two phases: 1) a cross-sectional, in which 250 adults will be recruited for the collection of anthropometric measures, food intake, and fasting blood samples to measure serum lps, lbp, lipid profile, ir, insulin-like growth factor, hs-crp, il-6, and glucose. 2) intervention phase, in which 50 overweight subjects will be randomly assigned to either receive a daily probiotic (25 subjects) or a placebo capsule (25 subjects) during the intervention period.

general objective: to study the relatedness of obesity, with the associated metabolic endotoxemia and low-grade inflammation, and the effectiveness of probiotics intervention in adults, in uae. specific aims: * investigate the link between metabolic derangements associated with obesity and levels of lps and lbp among the population in sharjah, uae. * to examine the associated factors of obesity among the same population, including socio-demographic data, anthropometric measures, body composition analysis, and food frequency assessment. * to investigate the correlation of the inflammatory marker il-6 and hs-crp to the levels of endotoxemia in lean, overweight and obese subjects. * to evaluate the change in endotoxemia, body mass index (bmi) and inflammatory markers, after consumption of probiotics capsules of blended strains of lactobacillus for 8 consecutive weeks among overweight and obese individuals.

Eligibility criteria:
inclusion criteria: * accepts healthy volunteers * 250 male and female * age (18 - 55 yrs.) * living in dubai or sharjah. exclusion criteria: * pregnant breastfeeding or post menopause female * individuals with thyroid * individuals with liver, kidney or internal organs disorders * individuals with signs of hypersensitivity * individuals with have known allergy to probiotics, immune-disorder, malignant tumor. * individuals with any major surgery during the last 6 months * current smokers individuals with, acute illness within 2 weeks before collecting blood samples
a single-dose open-label study of xoma 358 in subjects with congenital hyperinsulinism

Conditions: Congenital Hyperinsulinism

Summary: the purpose of this study is to evaluate the safety and clinical pharmacology of a single dose pharmacokinetics and pharmacodynamics of xoma 358 in subjects with hypoglycemia associated with congenital hyperinsulinism.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of congenital hyperinsulinism * duration of glucose levels less than 70mg/dl, by cgm, for an average of at least 120 minutes a day across baseline days -3, -2, and -1 with no single duration less than 60 minutes on any of the baseline days -3, -2, or -1, unless the subject received rescue treatment. * can safely washout of background medications used to treat hyperinsulinism. exclusion criteria: * use of any agent, such as diazoxide, octreotide, chronic systemic glucocorticoids, or β agonists that may affect glucose metabolism * body mass index ≥ 35 kg/m2 * pregnant females, females planning to become pregnant during the course of the study, females who have delivered 3 months before screening, or breastfeeding * male subjects who are planning a pregnancy with a female partner during the course of the study or within 4 months after administration of study drug.

Keywords: hypoglycemia congenital hyperinsulinism