Kornimate/medical-research-clean huggingface dataset:
prediction of development of scapular notching following reverse total shoulder arthroplasty

Conditions: Osteoarthritis; Rotator Cuff Tear Arthropathy; Reverse Total Shoulder Arthroplasty; Scapular Notching

Summary: the hypothesis is that computer simulated bony impingement of the bone surrounding the spherical glenoid implant (the glenosphere) along the scapular neck on three-dimensional (3-d) computed tomography (ct) imaging analysis is predictive of the location of clinical scapular notching that develops following reverse total shoulder arthroplasty (tsa).

the specific aims are: * determine the relationship between lateral glenoid offset and the development of scapular notching following reverse tsa * determine the ability of 3-d preoperative planning tools to define areas of scapular bony impingement on kinematic simulated shoulder range of motion that predict the development of scapular notching * compare the precision and accuracy of plain radiographs (2-d) versus ct (3-d) for measurement of scapular notching and postoperative implant position following reverse tsa (2-d versus 3-d) * determine the implant and anatomic factors that best correlate with clinical outcome following reverse tsa by retrospective analysis

Eligibility criteria:
inclusion criteria: * all patients having undergone reverse tsa at the cleveland clinic with a high quality preoperative ct of the operative shoulder and a minimum of two years out from surgery exclusion criteria: * all patients having undergone reverse tsa at the cleveland clinic with no preoperative ct or a low quality preoperative ct of the operative shoulder and/or less than two years from surgery

Keywords: shoulder joint computed tomography
a novel online calculator to predict long-term survival and recurrence risk of patients with gastric adenocarcinoma

Conditions: Gastric Cancer

Summary: this study aimed to develop a novel prognostic oxidative stress-immune-inflammatory score (posii score) and introduce an innovative online calculator designed to predict long-term survival and assess the recurrence risk of gastric cancer (gc).

from 2009 to 2020, this study analyzed gc patients underwent radical gastrectomy at three hospitals, dividing them into training, internal, and external validation cohorts. twelve blood indicators were analyzed. the posii score was developed in the training cohort using the least absolute shrinkage and selection operator (lasso) technique. additionally, two online nomogram calculators were created based on multivariate cox regression within the training cohort and subsequently validated in internal and external validation cohorts.

Eligibility criteria:
inclusion criteria:1) histopathologically diagnosed gastric adenocarcinoma, 2) undergoing radical gastrectomy for gc, 3) absence of tumor invasion into adjacent organs or distant metastasis, and 4) availability of complete laboratory data. exclusion criteria: 1) non-adenocarcinoma gastric cancers, 2) gastric stump cancer, 3) receipt of neoadjuvant therapy, 4) a history of other malignancies, and 5) insufficient clinical data or follow-up information.

Keywords: oxidative stress inflammation gastric adenocarcinoma nomogram recurrence risk
the prevelance of pulmonary manifestation in patients with inflammatory bowel disease

Conditions: The Prevelance and Complications of Pulmonary Manifestations in Patients With Inflammatory Bowel Disease

Summary: bronchopulmonary manifestations signs and symptoms are variable extraintestinal manifestations of ibd.

several cases like bronchiactsis, bronchitis, tracheobronchitis and broncholitis. none of this complications are specific for either crohns or ulcerative , however the majority of cases are related to ulcerative colitis.

Eligibility criteria:
inclusion criteria:all patients diagnosed ulcerative colitis and crohns disaese on conventional treatment and biological treatment - exclusion criteria:no exclusion criteria -
design of the efects trial

Conditions: Esophageal Cancer

Summary: it is well known that there is a considerable postoperative weight loss in patients undergoing esophageal resection for cancer. we believe that this weigh loss can be limited by administering postoperative enteral feeding (target: 1000 kcal/ day) via feeding jejunostomy for at least 6 weeks postoperatively. we hypothesize that patients undergoing esophageal resection for cancer will have a better overall survival with postoperative additional enteral feeding than when on regular oral diet alone.


Eligibility criteria:
inclusion criteria: * advanced ct2 n+ or ct3 nx * all histology * gej or distal esophageal acc * proximal or mid scc * curative intent with intention to treat * no m+ * at least two-field lymphadenectomy * all access: mie, left thoraco freno or r thoraco + laparotomy with intrathoracic or cervical anastomosis * all anastomosis (intrathoracic, cervical) exclusion criteria: * t4 * r2 * transhiatal * pt in definitive crt or rescue resection following definitive crt * palliative treatment * tumours in cervical esophagus * pharyngeal cancer with gastric pull-up

Keywords: surgery malnutrition nutrition, enteral
evaluation of a virtual home dialysis mentoring program (home)

Conditions: End Stage Renal Disease on Dialysis; Home Dialysis

Summary: the investigator plans to establish a virtual platform for home dialysis physician mentoring with the intent to: 1. formulate a practical, interactive, virtual curriculum in home dialysis 2. provide dedicated video conferences in home dialysis mentorship 3. measure knowledge awareness and attitudes towards home dialysis

home-based kidney replacement therapy offers enhanced quality of life and clinical advantages compared to conventional in-center hemodialysis. globally, there is an increased awareness of home dialysis. however, there is a lack of mentoring centers to support new programs and/or nephrologists to initiate and grow home dialysis.1, 2 critical prerequisites for a successful mentoring relationship include: * established excellence in home dialysis in the mentor center * willingness from both mentors and mentees to participate in the program * engaging, high quality clinical content, including sharing of best practices * lack of system barriers to establish home dialysis * dedicated metrics to measure success of the program the investigator plans to establish a virtual platform with the intent to: 1. formulate a practical, interactive, virtual curriculum in home dialysis 2. provide dedicated video conferences in home dialysis mentorship 3. measure knowledge awareness and attitudes towards home dialysis the investigator hypothesizes that an effective, sustained mentorship program will increase knowledge and awareness of home dialysis and will ultimately enhance overall home dialysis adoption.

Eligibility criteria:
inclusion criteria: * credentialed physicians at satellite healthcare * nephrology fellows at nephrology training program affiliated with satellite healthcare credentialed physician exclusion criteria: * any person who does not meet the inclusion criteria
transcranial direct current stimulation in patients with disorders of consciousness

Conditions: Vegetative State; Minimally Conscious State; Disorders of Consciousness

Summary: previous studies showed that anodal transcranial direct current stimulation (tdcs) applied to the left dorsolateral prefrontal (dlpf) cortex transiently improves performance of memory and attention. investigator assessed the effects of left dlpf-tdcs on coma recovery scale-revised (crs-r) scores in severely brain damaged patients with disorders of consciousness in a double-blind sham-controlled experimental design.

following severe brain damage and coma, some patients may remain in a vegetative state (vs) or minimally conscious state (mcs). at present, there are no evidence-based guidelines regarding the treatment of patients with disorders of consciousness (doc). investigator aim to assess the effect of single session anodal (i.e., excitatory) transcranial direct current stimulation (tdcs) of the left dorsolateral prefrontal cortex (dlpf) on the level of consciousness in doc patients in a double blind randomized sham controlled study. tdcs is a form of safe non-invasive cortical stimulation, modulating cortical excitability at stimulation sites via weak polarizing currents, previously reported to transiently improve working memory and attention by stimulating the left dlpf in healthy subjects and patients with stroke, parkinson's or alzheimer's disease.

Eligibility criteria:
inclusion criteria: * post-comatose patients * patients in vegetative/unresponsive or minimally conscious state * patients with stable cardiorespiratory parameters * patients free of sedative drugs and na+ or ca++ channel blockers (e.g., carbamazepine) or nmda receptor antagonists (e.g., dextromethorphan) exclusion criteria: * premorbit neurology antecedent * patients in coma or \<1week after the acute brain insult * patients with a metallic cerebral implant or a pacemaker (in line with the safety criteria for tdcs in humans)

Keywords: vegetative state minimally conscious state disorders of consciousness transcranial direct current stimulation
cardiac strains for optimization of crt in non-responders

Conditions: Chronic Heart Failure

Summary: the aim of this study is to investigate the possibility of optimizing the performance of crt-d in non-responding patients through utilization of cardiac strain speckle tracking

in approximately 30% of patients, cardiac resynchronization therapy (crt) fails to lead to any improvement of the patients' status. in this study, an investigation of a possible method of optimization through speckle tracking of cardiac strains is attempted. patients not responding to cardiac resynchronization therapy-defibrillators (crt-d) after 3 months are randomly divided into control and intervention groups. atrioventricular interval is adjusted so that e and a waves do not overlap and the interventricular interval subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. the left ventricular ejection fraction (lvef) and nyha (new york heart association classification improvement 3 months after optimization are evaluated and use of other strain combinations assessed.

Eligibility criteria:
inclusion criteria: * patients with symptomatic heart failure with nyha iii/iv, pharmacological treatment options exhausted, lvef below 30%, and qrs duration over 130ms who did not respond to the implantation of crt-d exclusion criteria: * age below 18 * response to the original crt implantation

Keywords: cardiac resynchronization therapy non-responders
a single arm study of traditional chinese medicine for plasma cell mastitis

Conditions: Plasma Cell Mastitis

Summary: this is a single-center, single-arm, open-label trial evaluating the efficacy and safety of traditional chinese medicine for plasma cell mastitis.

this is a single-center, single-arm, open-label trial evaluating the efficacy and safety of traditional chinese medicine for plasma cell mastitis. this study will include 50 patients with plasma cell mastitis. after providing written informed consent, the participants will receive traditional herbal medicine twice daily. efficacy will be assessed every 15 days. if the disease progresses, the participant will withdraw from the trial.

Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria for plasma cell mastitis. 2. women aged \> 20 years and ≤ 60 years. 3. karnofsky performance status (kps) scale score ≥ 70. 4. volunteers to participate in the study, provision of signed informed consent, good compliance and willingness to cooperate with follow-ups. exclusion criteria: 1. pregnant and lactating women; fertile women who provide positive results of baseline pregnancy test; women of childbearing age who are unwilling to take effective contraceptive measures during the whole study period. 2. patients with serious underlying diseases, such as diabetes, cardiovascular and cerebrovascular diseases, liver, kidney and hematopoietic system diseases. 3. allergic constitution, such as a history of allergies to two or more drugs or foods; or those who are known to be allergic to the ingredients of the drugs used in this trial. 4. recent use of antidepressants and other psychotropic drugs. 5. hormone and immunosuppressive therapy were used one month before enrollment.
rehabilitation for patients with pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: patients suffering from pulmonary arterial hypertension (pah) frequently remain symptomatic despite medical therapy. symptoms include breathlessness, poor exercise capacity and reduced quality of life. in many other serious heart or lung diseases it has been shown that physical rehabilitation improves patient's fitness and quality of life. in pah there are no clear guidelines and in general physical activity has traditionally been discouraged, although evidence for this advice is lacking. interesting research project in germany showed significant benefit for in-patient rehabilitation in pah patients. in this study we will perform a controlled clinical study of out-patient rehabilitation of patients with pah. we hypothesize that physical training of patients will result in increased exercise capacity and improved quality of life.


Eligibility criteria:
inclusion criteria: * all patients must satisfy current diagnostic criteria for pulmonary artery hypertension based on their historical right heart catheter data (within 4 years of study enrollment): mean pap \>25mmhg at rest or \>30mmhg with exercise, by a pcwp \ 3 wood units. * willing and able to participate in 24 bi-weekly rehabilitation sessions, and medical follow-up. * stable dose of current pah-specific medication for 3 months prior to enrollment. * new york heart association (nyha) class ii-iii. * women of child-bearing age must demonstrate adequate contraception or undergo a pregnancy test. exclusion criteria: * functional class nyha class i or iv. * pah due to congenital heart disease, left heart disease, chronic lung diseases (vc or fev1 \< 60% of predicted) or chronic hypoxia. * acute intercurrent illness requiring hospital admission in the month proceeding screening. * any non-pah medical condition likely to interfere with participation in rehabilitation, e.g. musculoskeletal disorders. * any uncontrolled or terminal non-pah medical condition likely to interfere with completion of the study, according to the judgment of the study physician. * participation in another rehabilitation scheme within 6 months of enrollment in the study. * current participation in another clinical trial. * pregnancy or planned pregnancy during the study period.

Keywords: rehabilitation
paxil cr bioequivalence study brazil

Conditions: Depressive Disorder

Summary: the study is prospective, open, randomized, crossover in steady state and the volunteers received multiple doses of the drug test and reference (two periods of drug administration).

full title: relative bioavailability study between the formulations: paroxetine hydrochloride 25 mg tablet with controlled release (paxil cr) manufactured by glaxosmithkline inc. - mississauga - canada (test formulation) and paroxetine hydrochloride 25 mg tablets with controlled release (paxil cr) manufactured by smithkline beecham (cork) limited - cidra - puerto rico (reference formulation), fasted administration in healthy volunteers for both genders. the study is open, randomized, crossover in steady state and the volunteers received multiple doses of the drug test and reference (two periods of drug administration). the population is composed of 60 healthy volunteers, adult of both gender, with age between 18 and 40 years, with a body mass index (bmi) between 18.5 and 27. volunteers have weight above than 50 kg. 50% of the volunteers recruited are female and 50% male. there are not restrictions regarding the ethnic group.the relative bioavailability of the formulations after oral administration in steady state will be evaluated based on statistical comparisons of relevant pharmacokinetic parameters obtained from data of concentration of drug in blood. the concentration of paroxetine hydrochloride (controlled release) will be measured by an appropriate analytical method and valid after the drug administration.the pharmacokinetic samples will be collected at steady state in each fasting period. the safety assessment will include evaluation and clinical monitoring, vital signs monitoring, ecg, and laboratory tests. adverse events will be monitored throughout the study.

Eligibility criteria:
exclusion criteria: * hypersensitivity to the study drug or to compounds chemically related; * history of serious adverse events; * concurrent or recent use of other antidepressives, schizophrenia, anticonvulsant; * history of liver, heart, gastrointestinal or renal illness; * ecg findings not recommended according to the investigator judgement; * the volunteer ingests more than 5 cups of coffee or tea a day. inclusion criteria: * man and woman (since they are not pregnant or breastfeeding); * age between 18 and 40 years; * non-smoker and not addict; * mass index between 18,5 and 27; * good health conditions or without significant illness, by judgement of a legally qualified professional; * sign the informed consent.

Keywords: fast condition paroxetine reference/test healthy volunteers bioequivalence
effectiveness and safety of ingn 201 in combination with chemotherapy versus chemotherapy alone

Conditions: Carcinoma, Squamous Cell

Summary: there is a need for more treatment options for patients with recurrent squamous cell cancer of the head and neck (scchn). these tumors usually have a variety of genetic defects that include disruption of the p53 pathway, a pathway that would ordinarily work to prevent the development of tumors. in this study the transfer of the p53 gene to tumor cells using a modified adenovirus (ingn 201) in combination with chemotherapy (cisplatin and fluorouracil) will be compared to chemotherapy with cisplatin and fluorouracil in patients who have failed surgery and radiotherapy.


Eligibility criteria:
* 18 years or older * must have had radiation treatment * eligible for chemotherapy * not eligible for surgery

Keywords: recurrent squamous cell carcinoma of the head and neck
heparin-induced thrombocytopenia registry

Conditions: Heparin-Induced Thrombocytopenia

Summary: the purpose of the heparin induced thrombocytopenia registry is to explore the frequency of heparin-induced thrombocytopenia (hit) at brigham and women's hospital and to assess its mortality rate. retrospective 3 years, looking forward prospectively.

heparin-induced thrombocytopenia (hit) is an immune-mediated adverse drug reaction with potentially fatal complications of venous and arterial thrombosis. hit with thrombosis causes prolonged hospital length of stay and is associated with catastrophic outcomes such as extremity amputation as well as death. the fear of hit has led to some proposals to minimize hospital use of unfractionated heparin (ufh) and low molecular weight heparin (lmwh) and to substitute other anticoagulants that have not been reported to cause hit. therefore, the frequency of confirmed hit and the frequency of determining whether ufh or lmwh is the causative agent urgently require further investigation. at bwh, we have placed patient safety at a premium. we have a patient safety committee and a patient safety officer. hit has been identified as one of the primary problems requiring urgent policy decisions. consequently, we have formed a multi-disciplinary team of physicians, pharmacists, nurses and physician's assistants to improve safe medication practices for patients receiving anticoagulation. our primary objectives are to establish an hit registry which will provide information on: 1. incidence of hit associated with ufh and lmwh 2. outcomes of patients with hit 3. adverse events associated with alternative anticoagulants used to treat hit we will obtain data with respect to: drug, dose, route of administration, duration of therapy, platelet count, platelet nadir, co-morbidities (coronary artery disease, diabetes mellitus, myocardial infarction, hypertension, pulmonary disease, chronic renal failure, malignancy, liver disease, surgery, sepsis), baseline characteristics (age, sex, weight), pregnancy status, serum creatinine, ast, alt, hematocrit, hemoglobin, venous and arterial thrombotic events (dvt, pe, cvc), 30-day mortality rate, alternative anticoagulant therapy, and duration of therapy. time and method of data collection: chart review for the duration of hospitalization: hemorrhagic event, thrombotic events, and 30-day mortality rate.

Eligibility criteria:
all patients hospitalized at bwh who have a pf4-positive antibody test

Keywords: heparin unfractionated heparin low molecular weight heparin anticoagulation thrombocytopenia thrombosis venous thrombosis pulmonary embolism
the quality of life of cerebral palsy child carers

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is characterized by a sensory-motor deficiency, involving disturbance of muscle tone, posture and voluntary movement. children who are afflicted need special intense care for their carers

introduction: cerebral palsy (cp) is characterized by a sensory-motor deficiency, involving disturbance of muscle tone, posture and voluntary movement. children who are afflicted need special intense care for their carers. objective: the objective of this study was to analyze the quality of life of cp child carers attended in the physiotherapy sector of a philanthropic institution on maceió - al. methods: 62 carers were assessed in the period from the 18th to the 29th of february 2008, in which 96.7% were female carers and 3.7% male. the form for the collection of data from the carers, elaborated by the researchers and the whoqol-26 quality of life questionnaire were utilized as as instruments.

Eligibility criteria:
inclusion criteria: * children who were attended by associação dos pais e amigos dos excepcionais (apae), maceió, alagoas * they had cerebral palsy exclusion criteria: * child who had not cerebral palsy * child under 2 years old

Keywords: cerebral palsy caregivers quality of life
different crystalloids on aki in shock

Conditions: Shock

Summary: the goal is to observe that the incidence of acute kidney injury in patients who need fluid resuscitation when resuscitated with saline or acetated ringer's sodium.

fluid resuscitation is important to shock patients. saline is the classical fluids for resuscitation. however, studies showed that resuscitation with saline could increase the incidence of hyperchloremia and acute kidney injury. thus, the goal is to observe that the incidence of acute kidney injury in patients who need fluid resuscitation when resuscitated with saline or acetated ringer's sodium.

Eligibility criteria:
inclusion criteria: * shock patients who need fluid resuscitation with risk factors of acute kidney injury exclusion criteria: * patients with a history of chronic kidney injury and hemodialysis therapy

Keywords: shock acute kidney injury crystalloid