Kornimate/medical-research-clean huggingface dataset:
from genetics to transcriptomics to unravel the mechanisms behind a poor outcome in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: ms is a heterogeneous disease either in its response to treatment or clinical manifestation. indeed, the natural history of ms is varying from a benign condition to a devastating and rapidly incapacitating disease. clinical heterogeneity could also be cellular and / or molecular. the aim is to identify from omic analyses, at the early stage of the disease, differentially expressed molecules and / or cell subpopulations derived from cd8 + t lymphocytes and / or cd4 + t lymphocytes and / or b lymphocytes and monocytes from patients with aggressive versus non-aggressive, compared to a cohort of healthy controls


Eligibility criteria:
inclusion criteria : common criteria for retrospective ms patients: * patients aged 18 years or older * clinical isolated syndrome (cis) with or without dissemination in space * patients affiliated to an appropriate health insurance criteria for aggressive ms group • start of a 2nd line therapy within the two years following the cis criteria for non aggressive ms group * no conversion according to mcdonald criteria from clinical isolated syndrome to multiple sclerosis within 2 years or * conversion based to mcdonald criteria treated or not with first line disease modifying therapy within 2 years. * have a minimum of least 2 years of follow-up. healthy volunteers * aged 18 years or older * no history of clinically isolated syndrome or ms pairing criteria : * age +/- 5 years * sex prospective ms patients * patients aged 18 years or older * clinical isolated syndrome (cis) with or without dissemination in space * patients affiliated to an appropriate health insurance exclusion criteria : * ongoing participation to a another study * refusal to genetic analyses * immunosuppressive drug at the time of blood collection * adults under a legal protection regime (guardianship, trusteeship, judicial safeguard) * pregnancy
value of renal vascular doppler sonography in management of decompensated heart failure

Conditions: Cardiorenal Syndrome

Summary: although the traditional determinant of renal dysfunction in heart failure was suggested as decreased cardiac output and renal hypo perfusion, recent studies have demonstrated the association of persistent systemic venous congestion and kidney dysfunction. relief of the congestion has demonstrated to improve renal functions in decompensated heart failure. the current trial was set up to investigate the changes of renal venous impedance and renal arteriolar resistivity indices with diuretic therapy, in patients with congestive renal failure. the investigators asked whether measurement of renal venous impedance index or renal arteriolar resistivity index can guide the practice of diuretic therapy.


Eligibility criteria:
inclusion criteria: * decompensated heart failure * elevated serum creatinine levels on admission exclusion criteria: * atrial fibrillation * obstructive uropathy * patients with ascites * patients who exposed the potential nephrotoxic drugs in the previous week (metformin, antibiotics, chemotherapeutics, iodinated contrast agents and non-steroidal anti-inflammatory agents) * patients who needed positive inotropic agents

Keywords: cardiorenal syndrome, decompensated heart failure, renal resistivity index, venous impedance index, kidney failure
a cost-effective handheld breast scanner for use in low resource environments: a validation study

Conditions: Breast Cancer

Summary: validation of the pefs to detect breast tumors will be performed by means of a prospective trial. subjects will participate for 1 clinic visit. readings from the pefs will be studied for reproducibility and predictive ability. data analysis will be iterative, moving on with each modification of the device until the final prototype is created.

phase 2a of this study is directed primarily at prototype development, creating, testing, and modifying a 4x4 finger array device with a small footprint that is battery powered and reliable. the testing in this phase is aimed at proving that modifications did not degrade the screening sensitivity of the original lab prototype. target enrollment is up to 100 patients to verify that the investigators have reproducible values in the same patient. each breast will be evaluated and compared against each other whether it is considered normal or abnormal tissue. data from patients both normal and abnormal regions will be compared and used to determine predictive value and accuracy in this prototype. the patient population will be women and men 18 years of age or older with symptomatic breast lump either by palpation or imaging. symptomatic individuals scheduled to undergo diagnostic exam will be recruited from all patients presenting for breast evaluations at dr. brooks clinical practices who meet all the inclusion and exclusion criteria. consent will be obtained prior to any study related activities. the pefs evaluation will be performed by a trained individual. subjects will be scanned in supine position without breast immobilization - similar to ultrasound testing. the pefs data is recorded and processed by an automated software algorithm and the results are displayed topographically on a breast-map with red areas showing positive findings and black areas showing negative findings. quantitative data will be documented and analyzed for accuracy metrics. results will not be given to subjects nor recorded in their medical records. because this study is not a clinical utility study, results will have no effect on clinical care decisions. the pefs evaluation may add between 10 and 30 minutes to the clinic visit. no imaging or pathology tests are being done for research purposes.

Eligibility criteria:
inclusion criteria: 18 years or older * women or men with symptomatic breast lump by palpation or imaging exclusion criteria: * under 18 years of age
impact of donor and recipient st2 / il-33 pathway after heart transplantation

Conditions: Heart Transplant Failure and Rejection

Summary: evaluate the association between donor soluble protein st2 (sst2) serum levels and 30-day recipient mortality in order to improve graft screening.

soluble protein sst2 has recently become a prognostic biomarker in the context of acute myocardial infarction and chronic heart failure, and recent studies also show that sst2 is involved in acute rejection of the cardiac graft in recipients. experimental studies confirm that the st2 / il-33 pathway is involved in the process leading to cardiac transplant rejection in animals. in particular, administration of il-33 would have a positive effect on pre-clinical cardiac graft survival. no study have looked at the level of st2 / il-33 of the donor, with the purpose that it might reflect the condition of the transplanted heart and its initial level of immune tolerance and maybe predict the risk of subsequent dysfunction. in this non-interventional study, several blood samples will be taken on donors before organ procurement and on recipients prior to grafting, on day 7 and at the time of each myocardial biopsy (approximately 16 myocardial biopsies the first year). serum level of sst2 and il-33 will then be determined according to the elisa method on each blood sample. fifty consecutive couple donors/ recipients will be included in the study. this number of subjects is calculated to detect a doubling of the donor sst2 level between the two recipient groups with 30-day mortality and without mortality (potency: 90%, alpha risk: 0.05, bilateral).

Eligibility criteria:
inclusion criteria: * consenting recipients * consenting donors to organ/tissue donation for the purpose of scientific research exclusion criteria: * non consenting recipients * non consenting donors to organ/tissue donation for the purpose of scientific research * multi-organ transplantation
mindfulness-based intervention versus cbt for social anxiety disorder

Conditions: Social Anxiety Disorder

Summary: to conduct a prospective, randomized trial to compare the efficacy of a group mindfulness-based intervention adapted for social anxiety disorder (mbi-sad) versus cognitive behavior group therapy (cbgt).

the main aim of this comparative trial is to determine if the mbi-sad will be noninferior to cbgt in improving core symptoms of social anxiety disorder, depressive symptoms, self, esteem, disability and quality of life. a secondary aim is to examine whether treatment gains are maintained over a 6-month period. exploratory aims of the study are to: 1) determine if the mbi-sad enhances self-compassion and mindfulness relative to cbgt; 2) determine if changes in self-compassion and mindfulness mediate the clinical response to the mbi-sad; and 3) explore moderators of treatment response.

Eligibility criteria:
inclusion criteria: * dsm-5 diagnosis of social anxiety disorder (sad) of at least moderate severity * montgomery asberg depression rating scale score ≤ 25 * comorbid depressive disorders, panic disorder, agoraphobia, generalized anxiety disorder, specific phobias, eating disorders are allowed as long as the sad is primary and predominates the clinical picture. exclusion criteria: * coexisting axis i disorders excluding those listed in the inclusion criteria * coexisting medical conditions that can alter the clinical presentation of sad (e.g. parkinson's disease) * lifetime history of bipolar disorder or psychotic symptoms * substance-related disorders in the last 12 months * acutely suicidal or history of suicide attempt in the past five years * history of non-suicidal self-injurious behavior in the last 12 months * currently receiving psychotherapy * currently engaged in a regular meditation or yoga practice * unable to attend weekly group sessions
nasolabial soft tissue esthetics and maxillary changes in unilateral cleft lip and palate using presurgical infant orthopedics with different approaches

Conditions: Unilateral Cleft Lip; Nasoalveolar Molding

Summary: the nasal deformity is an abnormality in the appearance and structure of the nose in cleft patients having unilateral cleft lip and palate (uclp). it involves the displacement of the lower lateral nasal cartilage, oblique and short columella, depressed dome, overhanging nostril apex, and deviated septum. difficulty in breathing and smelling are the main problems of this deformity. rhinoplasty for clp patients is very complicated due to the complex nature of this type of deformity, especially in wide and bilateral cleft patients it is quite challenging.

the nasal deformity is an abnormality in the appearance and structure of the nose in cleft patients having unilateral cleft lip and palate (uclp). it involves the displacement of the lower lateral nasal cartilage, oblique and short columella, depressed dome, overhanging nostril apex, and deviated septum. difficulty in breathing and smelling are the main problems of this deformity. rhinoplasty for clp patients is very complicated due to the complex nature of this type of deformity, especially in wide and bilateral cleft patients it is quite challenging. the cleft width along with the nasal deformity and collapse in the nasal cartilage could affect the outcome of the surgical lip closure with the cleft width as a major factor affecting the tension produced in the closure and future collapse of the nose. there is a striking diversity in the literature regarding treatment protocols for uclp, with no standardized management protocols . clinical decision-making based on evidence is lacking due to the few randomized clinical trials comparing the effectiveness of different approaches. a recent systematic review conducted a comprehensive search aiming at identifying the different treatment protocols and effectiveness of using pre-surgical infant orthopedics (psio) and recommended the need for further well-designed and high-quality randomized clinical trials (rcts) in this area due to the unstandardized protocols with high diversity. various studies supported the positive effect of naso-alveolar molding (nam) appliance therapy on nasal symmetry in uclp treatment. the nam therapy decreases the severity of the initial cleft deformity and repositions deformed nasal cartilage and alveolar process, which has many beneficial results in the surgery outcome. taping has been assessed in infants with uclp and was deemed successful as well by a few studies. to our knowledge, no rcts are comparing the use of nam therapy to taping with the use of nasal elevators on uclp patients.

Eligibility criteria:
inclusion criteria: * infants with 0 (after birth) to 1 month of age * non-syndromic with no other medical conditions * unilateral complete cleft lip and palate * cleft width \> 5 mm exclusion criteria: * syndromic uclp or bilateral cleft lip and palate * incomplete uclp * cleft width ≤ 5 mm

Keywords: nam uclp pre-surgical orthopedics dynacleft
exploring clinical trial experiences of patients with migraine

Conditions: Migraine; Migraine Disorders

Summary: clinical study participation has historically been heavily biased toward specific demographics. this study will invite several participants to gather a wide range of information on clinical trial experiences for migraine patients. the aim of the study is to identify the factors that limit the ability of a person to enroll in, as well as complete a clinical trial for treatment of migraine. people with migraine who are invited to take part in medical research will benefit from the analysis of the data.


Eligibility criteria:
inclusion criteria: * patient is a minimum of 18 years of age * patient has been diagnosed with a type of migraine * patient plans to participate in an interventional clinical trial for the condition of migraine * patient has access to a home internet connection in order to provide regular updates through the course of the study exclusion criteria: * patient has an ecog score of 4 or higher * patient is not able to provide consistent digital updates as per study requirements * patient does not complete or agree to terms outlined in the informed consent form

Keywords: migraine
bedside therapeutic monitoring of β-lactam levels in newborns, children and adolescents admitted to intensive care.

Conditions: Intensive Care Unit Syndrome

Summary: this study evaluate the capacity of the mon4strat device for drug monitoring of β- lactam antibiotic concentrations in newborns, children, and adolescents admitted in intensive care units with a health care-associated infection.


Eligibility criteria:
inclusion criteria: * age younger than 18 years * newborns (preterm or not) in neonatal intensive care * infants, children, and adolescents in pediatric intensive care * clinically suspected or microbiologically proven sepsis that might be associated with ventilator-associated pneumonia or otherwise associated with health care * need for antibiotic treatment by piperacillin-tazobactam, ceftazidime, or meropenem of intermittent administration * informed consent form signed by parents/guardian * informed consent form signed by patients old enough to understand. exclusion criteria: * process for active limitation of treatment underway * suspected or known hypersensitivity to studied beta-lactams * renal failure, defined as serum creatinine \> 1.5 mg/dl or urine production \< 0.3 ml/kg for 24 h or anuria for 12 h. * co-administration of two β-lactam antibiotics * cystic fibrosis * no national health insurance coverage in french center * family unable to understand study-related information due to language or other communication issues * no consent obtained

Keywords: device drug monitoring β-lactam antibiotic health care-associated infection mon4strat
thermocool sf catheter versus thermocool catheter in isthmus-dependent atrial flutter ablation

Conditions: Atrial Flutter

Summary: porous tip catheter use reduces procedure time and rf time in atrial flutter ablation with the same safety.

new porous tip catheters appear more effective in atrial fibrillation ablation than conventional irrigated catheter, with the same safety. we could hypothesize porous tip irrigated catheters are more effective than conventional irrigated catheter, reducing procedure time and rf ablation time.we realize a randomized comparison study. for that, 70 patients with an indication for isthmus-dependent atrial flutter ablation will be randomized to conventional irrigated catheter ablation or porous tip irrigated catheter ablation. a ecg-holter examination will be done at 1 month follow up after catheter ablation, 6 and 12 months.

Eligibility criteria:
inclusion criteria: * all patients undergone to cti-dependent atrial flutter ablation. exclusion criteria: * left atrial flutter or atrial fibrillation * femoral venous access not available. * anticoagulation not therapeutic in patients at high thrombo-embolic risk * other contraindications to radiofrequency ablations: pregnancy, malignancy

Keywords: atrial flutter thermocool catheter thermocool sf catheter
radifocus (terumo) versus silverway (asahi) to deliver catheters during cardiac catheterization

Conditions: Anomalies Vascular

Summary: in some cases the standard j-tip guidewire cannot deliver the catheter into the aortic root, because of arterial loops or spasm. in these cases a hydrophilic guidewire (terumo) gives the right lubricity and good shape retention to guide the catheter through the artery. however, the terumo wire does not give much torque and could therefore easily penetrate side branches and cause dissection or perforation. the latest silverway guidewire has some new advantages which is easier to guide and could cause less complications while faster delivery of catheters to the aortic valve. the investigators aim to compare both guide wires.

during cardiac catheterization a catheter is threaded through the radial arteries to the aortic root with the support of a guide wire. the standard workhorse to deliver the catheter is a j-tip guidewire (spring coil wire). however, in patients with arterial tortuosity or spasm, this guidewire has low lubricity and no torque to direct the catheter because the outer coil and core are not connected together. if this problem is encountered, interventional cardiologists will use a hydrophilic polymer-coated guide wire. up to date there are several hydrophilic coated guide wires available. one of these is the radifocus guide wire m (terumo, japan). although it has better torque transmission than the spring wire, it still has low torque transmission due to a nitinol core structure, is less supportive and can easily enter side branches because of the high lubricity and therefore might cause dissections or perforations. in some cases, coronary angioplasty guide wires are needed to negotiate a highly tortuous artery, but they lack the support to advance the catheter. recently, the silverway guide wire has been created (asahi intecc co, ltd., japan) to overcome the problems that a spring- and polymer wire have. features that this new guide wire provide is hybrid coating and act one technology that connects the wire core and coil to ensure one to one torque transmission the investigators aim to compare both guide wires in deliverability, workability and complication rate.

Eligibility criteria:
inclusion criteria: * indication for radial artery access for diagnostic cardiac catheterization * being able to receive the per standard protocol verapamil and nitroglycerin administration via radial artery * not able to deliver a diagnostic or guiding catheter to the aortic root by means of the standard j tip wire * no signs of early complication after initial attempt with the j tip wire such as dissection, perforation or hematoma * age ≥ 18 years exclusion criteria: * femoral or brachial artery access * patients with known crest syndrome or other forms of scleroderma * emergent indication for cardiac catheterization such as an acute coronary syndrome

Keywords: cardiac catheterization radifocus guide wire silverway guide wire
pai-1 expression in non-scarring hair loss

Conditions: Androgenetic Alopecia; Telogen Effluvium; Alopecia Areata

Summary: this study will investigate whether subjects who suffer from hair loss have increased levels of pai-1 compared to age-matched control subjects. the level of pai-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.

this study will compare the levels of pai-1 expression in subjects with different forms of non-scarring hair loss and in these subjects vs normal age-matched controls. hair loss subjects will have their northwestern memorial hospital and northwestern medical faculty foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. all subjects will have a 4 mm punch biopsy on the scalp. tissue pai-1 levels from scalp skin biopsies will be determined by immunohistochemical staining. samples will be kept for approximately 15 years, after which time unused samples will be destroyed.

Eligibility criteria:
inclusion criteria: * age-matched control subjects who do not have a history of hair loss * a clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin * all subjects must have given signed, informed consent prior to registration in study exclusion criteria: * history of previous hair transplantation * current and past use of medications topically on the scalp * clinical or pathologic diagnosis of a scarring alopecia * history of inflammatory conditions of the scalp such as psoriasis

Keywords: alopecia hair loss
compare effects of the mirror therapy and robotic mirror therapy in electroencephalography of healthy adults and stroke patients.

Conditions: Healthy Adults; Stroke Patients

Summary: mirror therapy has recently attracted increasing attention; however, most patients have the difficulties to perform mirror therapy due to limited imaginary ability. a mirror robotic hand system was developed, which consisted with a wearable exoskeletal hand, sensor glove, and a control box. the patient's unaffected hand wears the sensor glove, the affected hand wears the wearable exoskeleton hand, and the unaffected hand does the certain transitive and intransitive tasks as the mirror group, and then makes the affected hand do the same movements driven by the exoskeleton robotic hand. the investigators hypothesize that combining both approaches might facilitate the sensorimotor cortex that controls movement and might augment somatosensory input and further treatment efficacy. this study is aimed at investigating the effects of mirror therapy and robotic mirror therapy on motor cortical activations in healthy adults and stroke patients using electroencephalography. all participants will perform the conditions of resting, moving right hand with or without robotic hand as the baseline data, then they will do mirror therapy using the right hand as active hand, or wearing robotic hand doing mirror therapy in random sequence. electroencephalography (eeg) assessment will be done to assess the neurophysiologic effects of the different interventions. the investigators will use a questionnaire to assess the subjective opinion about the different interventions. combined with execution (video aoe). the investigators will use the pair-t test to assess the within subjects differences in eeg and the questionnaire results. this study will be done during 2020/02/01 - 2021/03/31.


Eligibility criteria:
inclusion criteria: * healthy adults: right handed, with normal upper extremity and cognition functions * stroke patients:one side upper limb spasticity exclusion criteria: * 1. wrist weakness or deformity 2. skin problem 3. musculoskeletal injury of upper extremities

Keywords: mirror therapy robotic mirror therapy electroencephalography stroke