Kornimate/medical-research-clean huggingface dataset:
particulate vs. nonparticulate epidural steroid injections for lumbar foraminal stenosis

Conditions: Lumbar Spinal Stenosis

Summary: chronic lumbosacral radiculopathy secondary to lumbar spinal stenosis affects a large number of individuals, and there is a general lack of consensus in the medical community in terms of effective treatments for this problem. by assessing the relative efficacy of transforaminal epidural injections of particulate and nonparticulate steroids, this study attempts to further define the appropriate conservative management of painful unilateral radiculopathies due to unilateral lumbar foraminal stenosis. patients will be randomized to receive a transforaminal epidural injection of either a particulate (kenalog) or nonparticulate (decadron) steroid. outcomes will be assessed at 2 weeks, 6 weeks, 3 months, and 6 months following the injection.


Eligibility criteria:
inclusion criteria: * english speaking/reading adults age 18-90 years * patients with complaints of unilateral radicular lower extremity symptoms * nrs pain score \>= 5 * pain symptoms for at least 1 month's duration * patients deemed appropriate for lumbar transforaminal epidural steroid injections by treating spine specialist * targeted injection level for l4 or l5 * mri of lumbosacral spine that demonstrates and confirms single-level neural compression secondary to unilateral lumbosacral foraminal or subarticular stenosis consistent with clinical history and findings * lumbar foraminal stenosis severity of grades 1, 2, and 3 exclusion criteria: * patients with multiple symptomatic levels * patients who are deemed not appropriate to undergo lumbar transforaminal epidural steroid injections (e.g., allergy to local anesthetics, radiographic dye contrast, patients with high bleeding tendency, pregnancy) * patients involved with litigation or worker's compensation cases * patients who are unable to answer the questionnaires and perform follow-up visits * patients who have active, concurrent painful diagnoses (e.g., hip osteoarthritis, greater trochanteric pain syndrome, knee pain, peripheral vascular disease, or peripheral neuropathy) that may confuse clinical picture and impact patients' rating and perception of their low back and radicular symptoms * patients with other spinal pathologies confirmed on imaging that may explain patient's pain * patients who have additional severe foraminal stenosis inferior to the symptomatic level (e.g., symptomatic l4 foraminal stenosis with severe l5 foraminal stenosis) will not have those levels injected * non-english speakers
behavioral economic treatment to enhance rural (better) living

Conditions: Alcohol Use, Unspecified

Summary: the purpose of this trial is to get feedback to help develop programs delivered by phone and text messages to improve wellness and health behaviors. this study will enroll adult participants that have been seen in primary care settings and live in rurally designated areas.

this study will evaluate acceptability and feasibility of two remotely-delivered behavioral economic intervention components, alone and in combination, using remote text message delivery. the two intervention components are an episodic future thinking component and a volitional choice component. the goal of this work is to develop and determine acceptability and feasibility of a well-specified, accessible, and theory-driven mobile health intervention to reduce harmful alcohol use in people living in rural regions.

Eligibility criteria:
screening inclusion criteria: * adults presenting in michigan medicine primary care * home address in a rurally designated area (e.g., zip code, county), * documented alcohol use in the electronic health record (ehr) (e.g., alcohol use disorder diagnosis, alcohol misuse or heavy alcohol consumption). baseline inclusion criteria: * an alcohol use disorders identification test (audit-c) score of ≥3 in females or ≥4 in males * regular access to an internet-enabled device (e.g., smart phone, computer, tablet). exclusion criteria: * does not understand english * currently pregnant * unable to provide informed consent due to medical/psychiatric reasons * currently in treatment for a substance use disorder.

Keywords: heavy alcohol consumption alcohol misuse
determination of the incidence of endometriosis and or adenomyosis in patients diagnosed with polycystic ovary syndrome, or the incidence of polycystic ovary syndrome in patients diagnosed with endometriosis and or adenomyosis

Conditions: Endometriosis; Polycystic Ovary Syndrome; Adenomyosis

Summary: the study was designed as a multicenter, prospective cross-sectional cohort study. the research population will consist of patients under the age of 40, diagnosed with endometriosis and/or adenomyosis and polycystic ovary syndrome, who applied to the obstetrics and gynecology outpatient clinics in 13 centers. according to the results of the sample size analysis, it was planned to terminate the study when 1225 patients with polycystic ovary syndrome and 1225 patients with endometriosis and/or adenomyosis were recruited.

for the diagnosis of polycystic ovary syndrome, rotterdam criteria will be used. hyperandrogenism will be determined clinically by ferriman-gallwey scoring, and biochemically by serum total testosterone and sex hormone initiating globulin (shbg). 21-24 and 28-31 of menstruation in patients with ovulatory dysfunction, oligomenorrhea (cycles lasting longer than 38 days). it will be determined by measuring the serum progesterone level between days polycystic ovarian morphology will be determined by transvaginal ultrasonography (8 mhz probe) by calculating the number of antral follicles and ovarian volume. serum anti mullerian hormone (amh) will be requested from patients being investigated for polycystic ovary syndrome. in order to exclude other conditions during the investigation in patients with suspected polycystic ovary syndrome, serum thyroid stimulating hormone (tsh), prolactin (prl) and 17-hydroxyprogesterone (17-ohp) levels will be checked in the first 7 days of menstruation. the diagnosis of endometriosis will be made by the presence of ovarian endometrioma and/or a deep infiltrating endometriosis nodule determined by transvaginal ultrasonography or by palpation of the endometriotic nodule on pelvic examination or surgical confirmation. the diagnosis of adenomyosis will be made by transvaginal ultrasonography or surgical confirmation. for polycystic ovary syndrome in patients diagnosed with endometriosis and/or adenomyosis; for endometriosis and/or adenomyosis in patients diagnosed with polycystic ovary syndrome, the above-described diagnostic investigations will be performed.

Eligibility criteria:
inclusion criteria: * having been diagnosed with endometriosis by ultrasound or surgery(after diagnosed) * being a newly diagnosed endometriosis patient * not using any hormones or additional drugs * not having undergone ovarian surgery * patients diagnosed with pcos according to the rotterdam diagnostic criteria exclusion criteria: * previously diagnosed with endometriosis, medically or surgically patients receiving treatment * patients who have undergone ovarian surgery
immediate load in dental implants using conventional drilling and piezoelectric osteotomy on aesthetic zone.

Conditions: Dental Implants; Tooth Loss

Summary: compare the survival rate of the implants placed using the ultrasonic technique and placed using conventional drilling, with an immediate load on the aesthetic zone.

main goals. compare the survival rate of the implants placed using the ultrasonic technique and placed using conventional drilling, with an immediate load on the aesthetic zone. specific goals. * evaluate the marginal peri-implant bone loss after the healing period through radiographs, from the day of surgery, to a month, to 3 and 6 months after and a year after the implants insertion. * evaluate the primary stability of each individual implant the day of their insertion to verify their load on the moment of surgery and also compare the values of each preparation techniques of implant bone preparation. * evaluate the secondary stability of each individual implant and compare the values of each preparation techniques. * evaluate the peri-implant clinic parameters within 3 and 6 months and a year after the insertion of the implants through these variables: probing depth and bleeding of probing.

Eligibility criteria:
inclusion criteria: * absence of teeth on the aesthetic zone, whether its an incisor, canine or premolar. * 3 months after the dental extraction without alveolar scar tissue remains. * bone availability of at least 5mm of width and 13mm of length. * at least 2 to 3 mm of soft tissue for the establishment of an adequate peri-implant biological width. * oclusal pattern that ensures prosthetic success. * implants need to have at least a 35 n and 70 isq index to be loaded. * index of plaque \< 20% and/or inactive periodontal disease. exclusion criteria: * acute myocardial infarction in the last 2 months. * uncontrolled coagulation disorders * uncontrolled diabetes (hba1c\> 7.5%). * radiotherapy on head/neck in the last 24 months. * immunocompromised patient. * history of medication related to osteonecrosis of the jaws. * psychiatric disorders, alcohol, drugs and large smokers (\>10 cigarrillos). * plaque index \> 20%. * need for simultaneous or previous peri-implant guided bone regeneration procedures.

Keywords: dental implants piezoelectric osteotomy piezoelectric surgery immediate load
evalutation of insulin sensitivity through hyperinsulinemic clamp in children with gh deficiency

Conditions: Growth Hormone Deficiency

Summary: data about the impact of growth hormone treatment on insulin sensitivity in children are quite controversial, due to the different surrogate indexes that have been used, like homa-ir, quicki, isi-matsuda or adipokine levels. the investigators aimed to evaluate insulin sensitivity through the euglycemic hyperinsulinemic clamp, considered the gold standard technique, in children affected by growth hormone deficiency and to compare the m-value with the most commonly used surrogate indexes of insulin sensitivity.

the investigators aimed of this study was to use the hyperinsulinemic clamp to evaluate the impact of gh treatment on insulin-stimulated glucose utilization (m-value) in a group of children affected by gh deficiency and to compare the clamp-derived index with the most commonly used surrogate indexes of insulin sensitivity. in all patients the auxological and metabolic evaluation was performed at baseline and after 12 months of gh treatment, while in controls these evaluations were only performed at baseline. in all children the investigators measured body height, body mass index (bmi) and waist circumference (wc). a blood sample was drawn after an overnight fast for the measurement of glucose, insulin, hemoglobin a1c (hba1c) and igf-i. this sample served as the baseline for the oral glucose tolerance test (ogtt). blood samples were collected every 30 min for 120 min for glucose and insulin measurements. as surrogate estimates of insulin sensitivity the investigators used the insulin sensitivity index, a composite index derived from the ogtt and validated by matsuda and defronzo (isi-matsuda). on a different day, as a gold standard measurement of insulin sensitivity the investigators performed the euglycemic hyperinsulinemic clamp. as other insulin sensitivity markers, the serum levels of adiponectin and resistin after an overnight fast were also measured.

Eligibility criteria:
inclusion criteria: * isolated idiopathic gh deficiency diagnosed by the auxological and biochemical criteria of the gh research society in prepubertal children * prepubertal children exclusion criteria: * children with multiple hormone deficiency * children receiving other hormonal replacement treatment * pubertal children
engagement in childhood-onset systemic lupus

Conditions: Lupus Erythematosus, Systemic; Depression

Summary: the goal of this observational (aim 1) and pilot study (aim 2) is to better understand how depression symptoms may contribute to how well adolescent and young adults with lupus follow-up with their lupus clinical care. the main questions the overall study attempts to answer are: 1. whether anhedonia (a core symptom of depression) predicts disengagement in care 2. whether a patient-tailored mobile health application built to improve both engagement in care and depression symptoms will be feasible and acceptable to adolescents and young adults with lupus. participants with systemic lupus, ages 15-24 from the bronx, new york will be asked to complete questionnaires; some will be asked to participate in focus groups to help adapt the mobile health app; participants will also be invited to join a pilot study to try the mobile health app for 6 months and answer questionnaires to document the experience.

this registration is exclusive to the pilot study (protocol aim 2). the primary objective of aim 2 is to assess the feasibility and acceptability of an adapted valera application (app) in adolescents and young adults (aya) with childhood-onset systemic lupus erythematosus (csle). as a part of aim 1 (not a component of this registration), using a recognized patient-engaged methodology, "adapt-itt"22, the study team will iteratively adapt and test the content and utilities of the app for csle aya. during the 6-month pilot study which constitutes aim 2, the investigator team will examine feasibility and acceptability through mixed-methods. feasibility and acceptability will be assessed via app use and validated feasibility and acceptability of intervention measures.

Eligibility criteria:
inclusion criteria: * participants 15-24 years old meeting american college of rheumatology (acr) revised sle classification criteria and/or european league against rheumatism/acr classification criteria and/or 2012 sle international collaborating clinic criteria and followed at the children's hospital at montefiore. * must be diagnosed with sle before 19 years of age (based on childhood-onset systemic lupus erythematosus (csle) definition) exclusion criteria: * non-spanish or non-english speaking * participants anticipating transitioning to an outside rheumatologist for lupus care within the period of study follow-up * current psychotic disorders. however, attention-deficit/hyperactivity disorder, anxiety disorders, obsessive-compulsive disorder, posttraumatic stress disorder, eating disorders, and substance abuse disorders are not uncommon among adolescents and young adults (aya) and will be allowed. suicidal ideations (si) and self-injurious acts (cutting) are common in depression and will be allowed (defined as passive si).

Keywords: engagement in care mobile health
identifying the effect and working mechanisms of myplan 2.0 in adults with type 2 diabetes

Conditions: Chronic Disease

Summary: the aim of this study is to investigate whether and how 'myplan 2.0' helps adults with type 2 diabetes to be more physically active or less sedentary. two groups will be created, an intervention group and a waiting-list control group.

the aim of this study is to investigate whether and how 'myplan 2.0' helps adults with type 2 diabetes to be more physically active or less sedentary. two groups will be created, an intervention group and a waiting-list control group. both groups will be tested during three testing waves: pretest, posttest and follow-up test. only the intervention group will be given acces to 'myplan 2.0'. 'myplan 2.0' consists of a website and mobile application targeting physical activity and sedentary behaviour. the intervention has a duration of five weeks.

Eligibility criteria:
inclusion criteria: * 18 years or older * type 2 diabetes * have access to internet * being computer literate exclusion criteria: * not dutch speaking

Keywords: physical activity sedentary behaviour type 2 diabetes ehealth mhealth self-regulation behaviour change techniques
the study for evaluate of satety and dfficacy of hemostatic device

Conditions: Coronary Artery Disease

Summary: the goal of this clinical trial is to compare the new pneumatic compression device tracelet with conventional compression method in patients undergone transradial coronary angiography. the main question it aims to answer is the achievement of successful hemostasis at 3 hours. researchers will compare conventional compression to see if new pneumatic device can provide better hemostasis.

although there are several devices available for radial artery hemostasis, conventional compression with a gauze pad is thought to be the easiest method. one of the devices with a pneumatic compression balloon is the tracelet™, and there is not much research comparing the device and conventional compression method. therefore, the investigators aimed to compare the pneumatic compression device tracelet with the conventional compression method in patients who underwent transradial coronary angiography/intervention. the primary endpoint was the achievement of successful hemostasis at 3 hours. successful hemostasis was defined as the absence of oozing and the absence of hematoma formation after the device was released. if incomplete hemostasis was observed after 3 hours, the achievement of hemostasis after an additional hour of compression was also considered successful. conversely, if hemostasis could not be established, it was defined as unsuccessful hemostasis. the secondary endpoints included the total banding time, local vascular complications classified according to the easy (early discharge after transradial stenting of coronary arteries) scale, pain or discomfort related to the transradial approach, which was assessed by the participants using the wong-baker faces pain rating scale and numeric pain rating scale, and the rao at one month.

Eligibility criteria:
inclusion criteria: * aged over 20 years * underwent coronary angiography under suspicion of coronary artery disease * agreed to participate in the trial before the coronary angiography procedure exclusion criteria: * bleeding tendency due to congenital or acquired disorders such as severe liver disease, thrombocytopenia (platelet count below 50,000 cells/μl) * those who were on anticoagulants. * patients who could not provide voluntary consent.

Keywords: coronary artery disease percutaneous coronary intervention hemostasis
study of treatment effects of combination therapy of lucentis plus reduced fluence pdt with visudyne in patients with exudative amd

Conditions: Age-Related Macular Degeneration

Summary: the purpose of this study is to determine the benefits, if any, of combination therapy with lucentis plus reduced fluence photodynamic therapy with visudyne.

the study will have two treatment groups. each group will receive intravitreal injections (injection of medication in the jelly-like part of the back of the eye). one group (group1) of approximately 15 patients will receive 0.5 mg of lucentis™ followed by reduced fluence photodynamic therapy (pdt) with visudyne ® 1-2 weeks later. the other group (group 2) of approximately 15 patients will receive 0.5 mg of lucentis™ followed by photodynamic therapy with visudyne on the same day. patients will be assigned at random to receive one of the two treatments arms in the study. the dose received at the first injection will be the same dose received throughout the study.

Eligibility criteria:
inclusion criteria: * ability to give informed consent * treatment- naïve patients with active, subfoveal, exudative amd * patients with visual acuity of 20/40-20/320 in the study eye * subfoveal choroidal neovascularization (cnv) must be at least 50% of the total lesion size total area of lesion components other that cnv must be less than 50% of the total lesion size * the lesion must be \< 5400microns in greatest linear dimension (gld) * lesion size \< 10 da * occult with no classic cnv lesions must have presumed recent disease progression: 1. blood associated with the lesion at baseline 2. loss of visual acuity in the previous 3 months: a: \> 5 letter loss (etdrs equivalent) or b: 2 or more lines using a snellen or equivalent chart 3. \> 10% increase in gld as assessed by fluorescein angiography in the previous 3 months * previous treatment for cnv with anti-vegf agents, intraocular steroids and/or photodynamic therapy with visudyne® in the study eye * geographic atrophy or fibrosis in the study eye * intraocular surgery within 6 weeks of enrollment * subretinal hemorrhage \> 50% of the total lesion * patients with intraocular pressure greater than 30 mm/hg on 2 pressure-lowering medications * patients with severe disciform scarring. * inability to make study visits * advanced glaucoma * allergies to porfins or a known hypersensitivity to any component of visudyne® * patients with porphyria * pregnancy or lactation

Keywords: macular degeneration
impact of methylxanthine intake and blue light exposure on adhesive shoulder capsulitis.

Conditions: Adhesive Capsulitis of Shoulder

Summary: adhesive shoulder capsulitis is a condition characterised by stiffness or lack of mobility of the shoulder. this results in a negative impact on quality of life and increased health care costs. inflammation is a key factor in the pathogenesis of these patients. in addition, poor sleep quality and/or sleep deprivation can increase the production of pro-inflammatory cytokines, which contributes to the development of chronic inflammatory and metabolic diseases. the most important function of sleep is recovery. good sleep promotes healing, aids in the recovery of the immune, neurological, musculoskeletal systems and is necessary for pain sufferers to improve. the quantity and quality of sleep has an impact on the subject's inflammatory and metabolic markers. in relation to the quantity and quality of sleep, it has been shown that foods and/or beverages rich in methylxanthine such as coffee, tea and chocolate can alter these parameters. as is the case with exposure to blue light emitted by electronic devices. the population are faced with deep-rooted habits in their daily lives that do not help to control pain in these patients. hypothesis: due to the above, the following hypothesis is established: lack of consumption of food or beverages rich in methylxanthine and limiting the use of mobile devices two hours before going to sleep favours recovery from adhesive shoulder capsulitis.


Eligibility criteria:
inclusion criteria: * subjects diagnosed with adhesive shoulder capsulitis aged between 18 and 60 years. exclusion criteria: * locked shoulder dislocations, shoulder arthritis, shoulder fractures, avascular necrosis, previous surgery in the hypochondrium region within the last year, having a medical or skin condition that prevents them from receiving tactile stimuli in the shoulder area, presence of a neurological or motor disorder, having diagnosed psychopathology, visual impairment, or subjects with other diseases that may affect sleep quality or inflammatory parameters.

Keywords: adhesive shoulder capsulitis metabolic profile inflammation mediators insomnia disorders biological rhythms