Kornimate/medical-research-clean huggingface dataset:
assessment of the gore® excluder® conformable aaa endoprosthesis in the treatment of abdominal aortic aneurysms

Conditions: Aortic Aneurysm, Abdominal

Summary: the purpose of the study is to assess the safety and effectiveness of the gore® excluder® conformable aaa endoprosthesis to treat an infrarenal aneurysm located in the abdominal aorta. performance of the gore® excluder® conformable aaa endoprosthesis will be judged by separate performance goals.

the study design is a prospective, nonrandomized, international, multicenter study comprised of two parallel substudies. the total subject population is 175 subjects with 80 subjects assigned to the short neck substudy and 95 subjects to the high neck angulation substudy. this clinical study will include up to fifty-six sites in the us. each enrolled subject will undergo periodic follow-up evaluations involving physical exams and contrast-enhanced computed tomography (ct) scans at specific, protocol-defined intervals for a period of five years following the gore® excluder® conformable aaa endoprosthesis implant. each substudy will be evaluated and reported independently from each other according to the safety and effectiveness endpoints. no comparative analyses between these substudies are planned.

Eligibility criteria:
inclusion criteria: 1. aaa meeting any of the following criteria: * maximum diameter ≥50 mm * rapid growth (\>5 mm in a 6 month period) * non-ruptured aaa presenting with clinical symptoms 2. adequate anatomy to receive the gore® excluder® conformable aaa endoprosthesis, including: * adequate iliac / femoral access * infrarenal aortic neck diameter 16-32 mm * infrarenal aortic neck length ≥10 mm * aortic neck angle ≤ 90˚ * distal iliac artery seal zone ≥10 mm * iliac artery diameter 8-25 mm 3. an informed consent form (icf) signed by subject 4. male or infertile female 5. able to comply with protocol requirements including following-up 6. life expectancy \> 2 years 7. age ≥ 21 years exclusion criteria: 1. mycotic or ruptured aneurysm 2. known concomitant thoracic aortic aneurysm which requires surgical intervention 3. renal insufficiency defined as creatinine \> 2.5 mg/dl or patient undergoing dialysis 4. new york heart association (nyha) class iv 5. aneurysmal, dissected, heavily calcified, or heavily thrombosed landing zone(s) 6. severely tortuous or stenotic iliac and / or femoral arteries 7. patient has body habitus or other medical condition which prevents adequate delineation of the aorta 8. participating in another investigational device or drug study within 1 year of treatment 9. systemic infection which may increase the risk of endovascular graft infection 10. known degenerative connective tissue disease, e.g., marfan or ehler-danlos syndrome 11. planned concomitant surgical procedure or major surgery within 30 days of treatment date 12. known history of drug abuse 13. known sensitivities or allergies to the device materials

Keywords: aortic aneurysm abdominal aorta stent graft aneurysm vascular diseases cardiovascular diseases
detection of monocytes/macrophages function and tim-3 expression in septic patients

Conditions: Sepsis; SIRS(Systemic Inflammatory Response Syndrome)

Summary: the imbalance between anti- and pro-inflammation often occurs in patients with sepsis. and continuous such imbalance could lead to immunoparalysis, which is characterized by loss of delayed type hypersensitivity, failure of primary infections eradication, and a predisposition of secondary nosocomial infections development. however, in which phase of sepsis does immunoparalysis occur is still unknown. so this study aims to tentatively understand this problem by checking monocytes/macrophages' antigen presentation and cytokine secretion，and by checking monocytes/macrophages' expression of tim-3 (the t cell transmembrane, immunoglobulin, and mucin-3), which is an inhibitory regulatory molecule, in sepsis patients' peripheral blood mononuclear cells.


Eligibility criteria:
inclusion criteria: * age over 18 years old; * fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 ℃ or lower than 36 ℃ (b)respiratory rate above 20/min, or carbon dioxide partial pressure below 32 mmhg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. * clinically suspected infection; exclusion criteria: * were under 18 years of age; * were refused by the patients or his/her familiality; * were suffering from acquired immunodeficiency syndrome,viral hepatitis,autoimmune diseases and hematology; * use medicine which can affect immune system,such as glucocorticoid and immunosuppressant * died within 24h after being taken into the icu, or refused to get involved in the study, or gave up treatment during the period of observation
daring birth - digital coaching solution to improve childbirth experience

Conditions: Childbirth Problems; Perinatal Depression; Anxiety in Pregnancy; Pregnancy Related; Postpartum Depression; Postpartum Anxiety; Fear of Childbirth

Summary: the aim of the study is to investigate the effectiveness of the daring birth digital coaching solution (the natal mind app) in enhancing the experience of childbirth. natal mind is designed for mobile phones and features a unique blend of emotion tracking, avatar-based interaction, and mass-customized psychoeducation and exercises. these features collectively work to improve the childbirth experience, alleviate pain experience during labor, and mitigate perinatal mental health (pmh) issues namely fear of childbirth (foc), anxiety, and postpartum depression. the primary outcome of this study is the improvement of the childbirth experience, as it has been recognized to be a fundamental step in preventing postpartum problems. the study uses a randomized controlled trial (rct) with two arms: an intervention arm, where participants will have access to the natal mind app with its full functionalities, and a control arm, where participants use the app only for answering the study questionnaires while receiving standard care.


Eligibility criteria:
inclusion criteria: * nulliparous status estimated time of delivery (etd) between 15.5. and 15.9.2024 between 20 and 28 weeks gestational age at the time of recruitment fluency in finnish intended maternity care and birth hospital located in finland aged 18 or above exclusion criteria: * referral to a fetal medicine unit diagnosed psychotic or bipolar disorders active substance abuse participation in another clinical study focusing on perinatal mental health
self-management of cancer-related fatigue by adolescents

Conditions: Neoplasms; Fatigue

Summary: this study will investigate self-management of cancer-related fatigue by adolescents through pilot study of an evidence based educational resource.

cancer-related fatigue is a prevalent and distressing symptom which has a significant impact on quality of life for children and adolescents with cancer and their families. evidence based guidelines issued by the oncology nursing society and national comprehensive cancer network recommend educational interventions for preventing and treating cancer-related fatigue.the primary study aim is to examine the relationships among: intensity of cancer-related fatigue; frequency of use of an evidence based educational resource for self-management of cancer-related fatigue; and perceived helpfulness of resource use. the secondary aim is to examine the relationship between the fatigue scale-adolescent (fs-a) and the symptom distress scale (sds) 'tired' item as measures of intensity of cancer-related fatigue. the tertiary aim is to examine the feasibility of recruiting and retaining adolescents with cancer for longitudinal study of cancer-related fatigue.

Eligibility criteria:
inclusion criteria: * adolescents 13-18 years inclusive * leukemia, lymphoma, or malignant solid tumor; newly diagnosed and within 2 weeks of initiating therapy * patient and consenting parent able to speak, read, and write english. exclusion criteria: * failure to meet all of inclusion criteria

Keywords: neoplasms fatigue self care
an evaluation of a psychoeducation program in individuals diagnosed with schizophrenia

Conditions: Schizophrenia

Summary: this study was conducted to explore the effect on social functionality of the psychoeducation program organized to guide individuals diagnosed with schizophrenia to identifying and recognize emotions in facial expressions. half of participants were assessed the psychoeducation program. other half of participants were used only measurement tests.

the difficulties those diagnosed with schizophrenia have with facial identification and identifying emotions are closely associated with the adverse symptoms of the illness. those diagnosed with schizophrenia need to be helped in forming interpersonal relations so that they can gain the skills needed to live in society. ın this study the investigators prepared a psychoeducation program for individuals diagnosed with schizophrenia. the program titled, "psychoeducation program for emotion identification and expression in those diagnosed with schizophrenia" was conducted with the patients in the intervention groups once a week for ten weeks. on the other hand there were a control group which weren't be applied any intervention. the investigators applied some tests to intervention and control group three times ( before intervention, after intervention and three months after intervention). this study was conducted at three community mental health centers (cmhc's). the patients who met the study inclusion criterias were determined in these centers. randomized psychoeducation and control groups were formed from these patients.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia according to dsm-iv * over the age of 18 exclusion criteria: * having cominication problems * having another psychiatric disease

Keywords: cognition facial expression facial recognition psychiatric nursing psychoeducation schizophrenia
a study of stereotactic radiosurgery (srs) to treat pain in the chest and/or stomach wall

Conditions: Thoracoabdominal Wall Pain; Secondary to Parietal Pleura or Parietal Peritoneum Disease

Summary: the researchers are doing this study to find out whether stereotactic radiosurgery (srs) is a safe, practical (feasible), and effective treatment for people with chronic tawp. the researchers will test different doses of srs to find the highest dose that causes few or mild side effects.


Eligibility criteria:
inclusion criteria: * patients must have a documented history of chronic (≥ 3 months) thoracoabdominal wall pain (tawp) attributable to ≤ 3 unilateral spinal levels as confirmed by diagnostic paravertebral nerve block or tens (if results of the paravertebral nerve block are inconclusive) performed by an attending anesthesiologist specializing in pain management prior to study enrollment. * patients must have tawp that is inadequately relieved by a trial of conventional pharmacologic therapy (defined as nrs pain score ≥ 4/10 while on treatment with conventional pharmacologic therapy for analgesia) as determined by an attending physician specializing in pain management. * kps ≥ 60% * age ≥ 18 years old exclusion criteria: * patients with a life expectancy of \< 6 months as predicted by the adult comorbidity index (ace-27, see appendix 1) * patients with active autoimmune connective tissue disease * patients with bilateral tawp * patients with preexisting pneumothorax * patients with preexisting excessive pleural effusion (extending \> 3 vertebral levels) * systemic chemotherapy delivered or planned to be delivered within +/- 5 days of srs * unable to undergo a diagnostic paravertebral nerve block * unable to undergo at least one of either a myelogram or spine mri * patients for whom external beam treatment plans to deliver the prescription srs dose to the lesion of interest cannot be safely designed as specified by the dose constraint guidelines in appendix 2 * evaluation of any radiation doses previously delivered to spinal cord/cauda equina and other critical structures (bowel, esophagus, lungs, kidneys, rectum) will be taken into consideration * if radiation dose from srs would exceed any normal tissue constraint as noted in appendix 2, the patient will be ineligible * abnormal complete blood count. any of the following: * platelet count \< 75 k/µl * hgb level \< 9 g/dl * wbc \< 3.5 k/µl * abnormal coagulation profile: inr \> 2.5 inr and/or aptt \> 80 seconds. patients who are on anticoagulation medication that may not be safely held for the myelogram procedure (≥ 5 days for antiplatelet agents and warfarin; ≥ 24 hours for low-molecular weight heparin formulations) will be excluded. * allergy to local anesthestics * local infection at the site of injection of anesthetic * severe spinal deformities with anatomic distortion (severe scoliosis/kyphoscoliosis) * severe respiratory disease (i.e. oxygen dependent)

Keywords: stereotactic radiosurgery (srs) ablation of the dorsal spinal nerve 22-176
analgesics in the pre-hospital setting: implications on hemorrhage tolerance - fentanyl

Conditions: Healthy

Summary: the purpose of this project is to test how fentanyl, an analgesic currently employed in the pre-hospital setting by the us army, alters the capacity to tolerate a hemorrhagic insult in humans.

pain management on the battlefield is critical for the wellbeing of the soldier. given that a hemorrhagic injury on the battlefield is virtually always associated with pain, it is paramount that the selected pain medication does not disrupt appropriate physiological mechanisms that are beneficial towards the maintenance of blood pressure and vital organ blood flow during that hemorrhagic insult. current guidelines for the selection of pain medications of a hemorrhaging soldier are based upon limited scientific evidence, with the vast majority of supporting studies being conducted on anesthetized animals. thus, the interaction between hemorrhagic shock and pain medications commonly employed on the battlefield is yet to be determined in the conscious humans. with this background, we will test the hypothesis that fentanyl will impair the capacity for a conscious human to tolerate a hemorrhagic insult. the obtained data will provide the necessary scientific evidence in humans to support the committee on tactical combat casualty care (cotccc) guidelines on the analgesic of choice for moderate to severe injuries where the casualty is in hemorrhagic shock. notably, such data will identify the analgesic that least compromises a human's ability to tolerate a hemorrhagic insult, ultimately providing critical information to the combat medic on which analgesic should be employed for such an injury.

Eligibility criteria:
inclusion criteria: * healthy * non-obese (body mass index less than 30 kg/m2) * body mass greater than or equal to 65 kg exclusion criteria: * subjects who have cardiac, respiratory, neurological and/or metabolic illnesses * any known history of renal or hepatic insufficiency/disease * pregnancy or breast feeding * current smokers, as well as individuals who regularly smoked within the past 3 years * positive urine drug screen * currently taking pain modifying medication(s)
management of combined fracture neck of femur and femoral deformity in osteogenesis imperfecta patient

Conditions: Osteogenesis Imperfecta

Summary: o.i with nof fixed by wagner technique and telescoping nail

osteogenesis imperfecta (sillence type iv) sustained neck of femur fracture after fall on ground. he had proximal femoral anterolateral bowing on top of inserted rod 4 years ago. he was treated with corrective osteotomy and intramedullary telescoping nail for deformed femur and wagner technique to fix nof fracture. one year after operation the patient gained satisfactory functional outcome with union of nof fracture and correction of femoral deformity. this rare case illustrates the anticipated difficulties in managing neck of femur fracture in osteogenesis imperfect patients. the method of fixation with wagner technique can achieve stable fixation for solid healing in fragility fractures like this and the least interference with telescoping nail insertion.

Eligibility criteria:
inclusion criteria: * oi exclusion criteria: * not receiving bisphosphonate

Keywords: osteogenesis imperfecta fracture neck of femur telescoping nail
effect of dietary fiber on non-dialysis patients with chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: the main objective of this study was to investigate the effect of dietary fiber on anemia and glomerular filtration rate in non-dialysis patients with chronic kidney disease. participants will be randomly divided into a dietary fiber intervention group and a blank control group. the patients in the dietary fiber intervention group will have dietary fiber intake survey conducted by dietitians on the basis of basic treatment. supplemented dietary fiber was given on the basis of daily diet, once a day, 1 piece each time, before meals, and the intervention lasted for 3 months. the blank control group was followed up without intervention. clinical data, blood, urine and stool samples were collected at the initial diagnosis and at each follow-up site.


Eligibility criteria:
inclusion criteria: * above 18 years old; * clinically confirmed (history, blood creatinine, kidney b-ultrasound, laboratory examination, etc.) as stage 3-5 chronic kidney disease, endogenous creatinine clearance was \< 60ml/min according to cockcroft-gault formula; * generally in good condition, have a good understanding of their own illness and physical condition, have self-awareness, and can communicate well with others; * hemoglobin 100-130g/l; * in a non-dialysis state. * dietary fiber intake \<25g/d; * voluntarily join the study, understand the significance of the test and the indicators to be measured, and sign the informed consent. exclusion criteria: * unwilling to join the study; severe infection: fever, cough and sputum, pharyngeal pain, abdominal pain, diarrhea, carbuncle and other skin and soft tissue infection and other clinical manifestations, blood routine white blood cell count beyond the normal range (10×109/l); * severe cardiovascular diseases: including chronic cardiac insufficiency grade 3 or above and various arrhythmias; * obvious hypoproteinemia: albumin less than 30g/l; * corrective measures for anemia (blood transfusion, erythropoietin, hif-phi, iron supplement) have been applied in the past 3 months; * tumor evidence: certain tumors have been detected or clinical manifestations and tumor markers suggest the possibility of tumor; * pregnant women; * recent history of heavy blood loss.

Keywords: dietary fiber ckd anemia glomerular filtration rate
a study on nutrition support therapy of patients with liver failure

Conditions: Nutrition

Summary: this study is a clinical trial to assess the efficacy of nutrition support therapy of patients with liver failure. patients were randomized to one of 2 groups to receive different nutrition and energy support treatment.

patients with liver failure (defined by apasl) induced by any precipitating factors were randomized to two groups; a treatment group and a control group. participants in treatment group were provided with a standard hospital diet that provided 25-30 kcal/kg/day . patients in control group receive diet guide

Eligibility criteria:
inclusion criteria: 1. male and female patients from 18 to 65 years of age; 2. patient inclusion criteria: jaundice (serum total bilirubin ≥5 mg/dl) and coagulopathy (inr ≥ 1.5 or prothrombin activity ≥ 40 %), accompanied by ascites and/or encephalopathy within 4 weeks. exclusion criteria: 1. surgery with in 4 weeks 2. three degree hepatoencephalopathy 3. malignant tumors 4. cardiac failure or respiratory failure 5. liver transplantation within observing period -
randomised trial comparing iron supplementation versus placebo in the treatment of anaemia after hip fracture

Conditions: Hip Fracture

Summary: at present our current practice is to provide a course of oral iron therapy for those patients with a post-operative haemoglobin which is below normal, but not severe enough to require a blood transfusion. such a practice is not without side effects from the iron tablets, namely ingestion, nausea, diarrhoea, constipation. there is little evidence in the literature to support the current practice of using iron, with only one small randomised trial suggesting such therapy is unnecessary. we propose to recruit 300 patients recovering from a hip fracture with a post-operative haemoglobin below 11g/l. for those patients willing to enter the study, half will be given oral iron therapy (ferrous sulphate 200mg twice daily) for one month. the haemoglobin will be checked when the patients attends the hip fracture clinic at 6 weeks after discharge.


Eligibility criteria:
inclusion criteria: * patients with anaemia after surgery for a hip fracture exclusion criteria: * absence of anaemia, inability to provide consent

Keywords: hip fracture iron therapy anaemia
dose responsive study of ringer's lactate solution in prevention of post-induction hypotension

Conditions: Post Induction Hypotension

Summary: to assess the dose responsiveness of ringer lactate solution in prevention of post-induction hypotension predicted by ultrasound guided inferior vena cava diameter in patients receiving general anesthesia. objectives primary - to find the optimum preloading dosage of ringer lactate to prevent post induction hypotension. secondary - to find the predictive incidence of post-induction hypotension according to age, gender, type of surgery and comorbidities.

all patients, after ultrasonographic inferior vena cava collapsibility index calculation, will receive lactated ringer's solution as per body weight and as per their allocated group in the receiving area. after induction inside the operating room, all patients will be monitored continuously using electrocardiography, pulse oximetry, noninvasive blood pressure measurement and capnography . heart rate, systolic - diastolic - mean blood pressure, oxygen saturation will be monitored as follows : 1. baseline parameters - prior to administration of intravenous ringer's lactate solution 2. t0 (after administration of intravenous ringer's lactate solution but prior to induction of anaesthesia), 3. t1-t10 (every minute for first 10 mins after induction of anaesthesia) our institutional standard practice of induction of anaesthesia with fentanyl (2 μg/kg), propofol (2 mg/kg) and vecuronium (0.1mg/kg ) will be followed and intubation will be done only after first 10 mins post induction. amount of mephentermine needed to correct hypotension despite rl infusion will also be calculated.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years american society of anesthesiologists (asa) physical status classification system group i and ii elective surgery under general anesthesia exclusion criteria: * age \ 65 american society of anesthesiologists (asa) physical status classification system group iii and iv systolic blood pressure ≥ 180 mmhg systolic blood pressure \< 90 mmhg pregnant women patients with abdominal mass or ascites emergency surgery