Kornimate/medical-research-clean huggingface dataset:
diagnostic of human immunodeficiency virus (hiv) and other sexual transmission diseases (std) in high risk populations: men who have sex with men (msm) users of chemsex

Conditions: HIV

Summary: the main objective is to offer diagnostic tests for hiv, hcv and other std in the risk group of men having sex with men (msm) users of chemsex

the main objective is to offer diagnostic tests for hiv, hcv and other std in the risk group (msm users of chemsex) with the purpose of conduct diagnosis, early treatment and monitoring of this infections and reduce the incidence rate of the same ones

Eligibility criteria:
inclusion criteria: * adults (≥ 18 years) * men msm/transgender referred from pep office * men msm/transgender referred from urgency service attended for acute intoxication or an std * men msm/transgender referred from std office * men msm/transgender referred from a local ong attended for chemsex use * specifically drug use for having sexual relations, at least once in a month in the lasts 6 months or more than 10 times the last year * reading and understanding ability * patients should be given written informed consent * negative hiv and hcv men * hiv positive men but hic negative referred from hiv daily hospital * disposal of sanitary card from catsalut exclusion criteria: * men that not accomplish inclusion criteria * drug use for another purposes not sexual * drug use for having occasional sexual relations, least than once in the past 6 months
comparison of supraclavicular and costoclavicular brachial plexus blocks in adult patients

Conditions: Diaphragm Injury

Summary: hemidiaphragmatic paresis is a common side effect of brachial plexus blocks such as supraclavicular or infraclavicular block techniques. it has been shown that diaphragma thickness is affected at some extent in supraclavicular block and also in costoclavicular block which is accepted as an infraclavicular approach. however, these two approaches have not been extensively investigated before in terms of the diaphragmatic paresis. here, it is aimed to compare these two methods considering their effects on diaphragma thickness in inspirium and in expirium. moreover, the performance properties such as motor and sensory block onset, needle visualization time, needle visualization difficulty, postoperative pain scores, and lastly the perfusion index which is known to be reflecting vasodilation will be investigated.


Eligibility criteria:
inclusion criteria: * adult patients who will undergone upper extremity peripheral block exclusion criteria: * coagulation disorders * paediatric patients * patients who do not accept regional anaesthesia * known local anaesthetic allergy * patients who are under anticoagulant therapy * pregnancy

Keywords: regional anaesthesia acute pain peripheral block
neuroprotection impact of cyclosporin a in cerebral infarction

Conditions: Stroke

Summary: the main objective of this study is to determine whether a single injection of csa after intravenous thrombolysis can significantly decreased the volume of cerebral infarction at day 30 ± 15 assessed with flair mri. secondary objectives are to determine whether a single injection of csa after intravenous thrombolysis is safe and effective regarding to death and disability.


Eligibility criteria:
inclusion criteria: * patients age ≥ 18 years and \<85 years * male or female, * patients with cerebral infarction of less than 4:30h, * nihss score between 6 and 18 * identification of a carotid artery occlusion in the territory in mri * consent of participation signed by the patient or, if it is unable to give the family or someone you trust if it is present. * patient beneficiary of a social security system. exclusion criteria: * known hypersensitivity to cyclosporin a or castor oil, polyoxyethylene * patient in st. john's wort, stiripentol, bosentan or rosuvastatin * history of immunosuppression recent (\<6 months): cancer, lymphoma, positive serology for hiv, hepatitis, ... * known hepatic (prothrombin time \<50%) * patients treated with sulfonylureas or nicorandil * patients treated with dopamine, adrenaline, noradrenaline or isoprenalin * uncontrolled hypertension defined as systolic blood pressure greater than 185mm hg and a diastolic pressure above 110 mmhg, * cardiogenic shock defined by systolic blood pressure below 80 mm hg * contraindication to thrombolysis: history of aic in the three months history of intracranial hemorrhage, neoplasm, subarachnoid hemorrhage, arteriovenous malformation * presumption of septic embolism or aortic dissection or pericardial effusion. * recent biopsy or surgery within 3 months * head injury less than 3 months * known bleeding diathesis, taking anticoagulants with inr\> 1.2 * hypoglycemia (blood glucose below 0.5 mmol / l) * known renal, creatinine greater than 130 mu / l * recent lumbar puncture \<7days * conditions prior psychiatric or neurological deficit does not allow objective analysis of disability * history of ischemic stroke or hemorrhagic * history of epilepsy and taking antiepileptic * exclusion criteria imaging * structured hypodensity scanner compatible with recent ischemic stroke * hematoma * other lesions (tumor or inflammatory cerebral venous thrombosis) * the scanner contraindications: allergy to iodine or major renal creatinine\> 130μl or mri referred to above * women of childbearing age, pregnant or not recognized effective contraception * patients in the measure of legal protection.

Keywords: volume of cerebral infarction stroke csa nihss
role of mri breast in detection of ductal carcinoma in situ

Conditions: Carcinoma in Situ

Summary: "this study investigates the role of magnetic resonance imaging (mri) in detecting ductal carcinoma in situ (dcis) in high-risk breast cancer patients.

improved detection rates of dcis in high-risk patients. enhanced diagnostic accuracy, reducing false positives and negatives. ductal carcinoma in situ (dcis) is a non-invasive breast cancer where abnormal cells are confined to the milk ducts. the breast imaging reporting and data system (bi-rads) is a standardized scoring system used to classify breast imaging findings. scores range from 0 (incomplete) to 6 (known biopsy-proven malignancy)."

Eligibility criteria:
inclusion criteria: * high-risk breast cancer patients with a family history of breast cancer or genetic predispositions (e.g., brca mutations). * patients aged 30-65 years. * patients willing to undergo breast mri screening for dcis detection. exclusion criteria: * patients with contraindications to mri imaging (e.g., pacemakers, claustrophobia). * patients with a history of prior breast surgery or interventions that may interfere with imaging interpretation.
prevention of recurrent caries with lactobacilli precal

Conditions: Dental Caries in Children

Summary: the aim of this study was to compare the effect of drops containing probiotic bacteria (lactobacillus reuteri 17938, lactobacillus reuteri pta 5289, biogaia ab, sweden) on the incidence of dental caries with placebo drops in preschool children undergoing comprehensive restorative treatment under general anesthesia or conscious sedation. the project will be conducted at three specialist centers (umeå university, umeå, sweden, maxillo-facial unit, halmstad hospital, sweden; eastman institute, stockholm, sweden) and employ a randomized placebo-controlled design with two parallel arms. the study will be performed double-blind and neither the parents nor the clinicians will be aware of the content of the drops. the follow-up period is one year.


Eligibility criteria:
inclusion criteria: * preschool children, 2-5 year of age * with early childhood caries (ecc) or * severe early childhood caries (s-ecc) * scheduled for restorations and extractions under general anesthesia or any form of sedation * the obligate requirement is that the child should be fully treated and managed with aspect to caries within a period of not more than two months. exclusion criteria: * medically comprised children * children with severe cognitive problems or dysfunctional families * families planning to relocate within the next year

Keywords: early childhood caries probiotic bacteria
exploring the influence of trptophan on the treatment of pouchitis

Conditions: Pouchitis

Summary: patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. the try pro pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.

participants with chronic pouchitis receive either a weight adapted supplement containing etiher trypotophan or a placebo after completing the standard treatment with antibiotics or probiotics for their pouchitis. endoskopy will be performed, stool and blood will be sampled, symptoms will be monitored.

Eligibility criteria:
inclusion criteria: * pouchitis (pdai \>= 7) * indication for the application of antibiotics and probiotics * age \>=18 years * informed consent exclusion criteria: * major surgery planned druing the intervention * high risk for malnutrition (nrs 2002 \>=3/ bmi \<18,5 kg/m\^2)

Keywords: pouchitis antibiotics probiotics tryptophan metabolites
combined effect of continuous and interval in addition to tadalafil drug on erectile dysfunction

Conditions: Erectile Dysfunction

Summary: erectile dysfunction (ed) is the persistent inability to attain and maintain a sufficient erection to permit satisfactory sexual performance. ed, a condition closely related to cardiovascular morbidity and mortality, is frequently associated with obesity. the importance of reducing cardiovascular risk factors remains fundamental to the overall vascular good health of the man, and that includes sexual vascular health. ed shares similar modifiable risks factors with coronary artery disease (cad). lifestyle modification that targets cad risk factors may also lead to improvement in ed.

sixty obese men with ed complaints will be divided to two groups, exercised and non-exercised groups; n= 30 patients in every group. both groups will receive five milligrams of tadalafil one time per day for 8 weeks but the exercised group only will receive - in addition to tadalafil - combined continuous and interval aerobic training, 3 session weekly for 8 weeks after detecting their target heart rate via the cardiopulmonary exercise test.

Eligibility criteria:
inclusion criteria: 1. sixty sedentary obese married men with bmi \> 30 kg/m2. 2. the age of participants will range from 40-50 years old. 3. blood pressure will be \< 140/90 mm hg. 4. the patients who will have ed at least from 6 months with iief-5 score \< 22. exclusion criteria: 1. alcoholic, smoker, hypertensive, diabetic, and addicted patients. 2. patients with pulmonary, renal, hepatic, and cardiac disorders. 3. lower limb arthritis or orthopaedic disorders that will hinder the training program. 4. prostatic inflammation, hyperplasia, and tumors. 5. participation in a structured sport program in the previous 6 months. 6. previous pelvic and genital surgeries.
influence of synacthen infusion on the results of adrenal venous sampling in patient with primary aldosteronism

Conditions: Primary Aldosteronism

Summary: the project is aimed to determine the value of synacthen infusion on the results of adrenal venous sampling in patients examined for primary aldosteronism

we aim to compare the results of adrenal venous sampling performed without and during synacthen infusion.

Eligibility criteria:
inclusion criteria: confirmed primary aldosteronism exclusion criteria: inability to undergo unilateral adrenalectomy

Keywords: primary aldosteronism adrenal adenoma arterial hypertension
pilot study of financial navigation program for improving financial toxicity among breast cancer in china

Conditions: Breast Neoplasm Female; Financial Toxicity; Financial Navigation

Summary: the goal of this pilot study is to access the feasibility and impact of a financial navigation program on improving financial toxicity among patients with breast cancer in china. the main questions it aims to answer are: * is the intervention feasible and acceptable among participants? * does the intervention enhance participants' cost-related health literacy? * does the intervention reduce participants' financial toxicity? researchers will compare the financial navigation program with usual oncology care to preliminarily evaluate its effectiveness. participants will receive comprehensive information support, including: * strategies on patient-physician costs discussion * skills for inquiring and tracking treatment-related costs * basic knowledge about health insurance * guidance on accessing and applying for financial assistance * suggestions for returning to normal life and work * strategies for holding a financial-related family meeting


Eligibility criteria:
inclusion criteria: * (1) newly diagnosed with breast cancer and undergoing surgery during this admission; * (2) female, age 18 years or older; * (3) receiving or expected to receive one or more of the following therapies: chemotherapy, radiotherapy, endocrine therapy, targeted therapy, and immunotherapy; * (4) eastern cooperative oncology group performance status 0-2; * (5) provided informed consent to participate in this study. exclusion criteria: * (1) diagnosed with ductal carcinoma in situ (dcis) * (2) presence of any serious psychiatric disorders; * (3) cognitive impairments; * (4) difficulty in reading, writing, or communicating in chinese.
eye rubbing and transient change in corneal parameters

Conditions: Ectasia

Summary: this study addresses the research question: how does eye rubbing affect corneal (clear part of eye) parameters in healthy volunteers the study objectives are: 1. to determine the corneal changes following eye rubbing 2. to assess tear film changes following eye rubbing 3. to investigate if there is an association between eye rubbing and axial length of the eye.

background a human eye has a front clear window called cornea. this cornea should ideally be spherical but in some subjects, this cornea gets deformed to a cone shape. this cone shaped cornea is called keratoconus. this keratoconus will cause blurring of vision which may require the use of a rigid contact lens or surgical intervention to improve vision. one of the etiological factors for keratoconus is eye rubbing. eye rubbing is very common in subjects with eczema and other chronic allergic conditions. it is believed that constant eye rubbing every few minutes over years may lead to permanent changes to corneal curvature leading to formation of keratoconus. it is known from previous studies that eye rubbing causes transient changes in the shape of the clear window of the eye, these changes are returned to baseline at 5 minutes following 1 minute of eye rubbing. although clinicians routinely advise such subject to refrain from eye rubbing and prescribe them long term anti allergic medication, there is paucity of scientific evidence on this. with the knowledge of rubbing induced changes to the clear part of the eye in relation to the axial length we will have a further understanding of those subjects who are more susceptible to moulding and mechanical injury of the clear part of the eye. if we can identify a relationship between eye rubbing and eye length then those subjects with a chronic stimulus to eye-rubbing, such as allergy etc, efforts can be made to protect the eye from rubbing induced changes to prevent disease progression (keratoconus). the aim of this study is to assess transient changes (if any) in corneal and surface tear film parameters in healthy volunteers after rubbing of the right eye for 2 minutes. the volunteers will undergo a tear film assessment and a corneal scan before and after eye rubbing on both eyes. in addition to these, the volunteers will also undergo a simple scan (iolmaster scan) to assess the overall dimension of their eyeballs before eye rubbing. the data from both eyes will be analysed.

Eligibility criteria:
inclusion criteria: * aged 18 years or above healthy exclusion criteria: * aged less than 18 years * subjects with: terminal illness, poor english language skills or a confused state history of previous ocular problems or surgeries history of contact lens wear not will to undergo simple \& quick scans and eye examinations

Keywords: corneal eye rubbing
is primiparity a risk factor for neonatal hyperbilirubinemia?

Conditions: Hyperbilirubinemia, Neonatal

Summary: neonatal hyperbilirubinemia elongates hospital stay and may require treatment. the investigators noticed that bilirubin levels were higher among infants of primipara mothers than among multipara mothers. as this data is dichotomic and easy to produce, and may influence the maintenance, the investigators decided to find out if primiparity is a risk factor for neonatal hyperbilirubinemia. the investigators intend to collect data from patient files during one year, and compare the bilirubin levels and length of stay between newborns to primipara mothers and multipara mothers.

neonatal hyperbilirubinemia elongates hospital stay and may require treatment. the investigators noticed that bilirubin levels were higher among infants of primipara mothers than among multipara mothers. as this data is dichotomic and easy to produce, and may influence the maintenance, the investigators decided to find out if primiparity is a risk factor for neonatal hyperbilirubinemia. the investigators intend to collect data from patient files during one year, and compare the bilirubin levels and length of stay between newborns to primipara mothers and multipara mothers.

Eligibility criteria:
inclusion criteria: * all infants that were born during one year in a single medical center and were transferred to well baby nursery, and were discharged from the well baby nursery. exclusion criteria: * infants who were transferred to neonatal intensive care unit due to any reason. * infants whose mother could not take care of them (due to admission to intensive care unit, or due to adoption)

Keywords: hyperbilirubinemia primiparity multiparity
application of a perineal protection device in vacuum-assisted births

Conditions: Vaginal Tear; Perineal Tear

Summary: visible birth tears are common in vaginal births, especially in vacuum-assisted births. one aim of obstetrical work is to minimize such injuries by an adequate birth management , for example with a proper perineal support. the medical device "babyslide®" was developed as an auxilliary device for perineal support and already evaluated in a multicenter randomized controlled trial in schweden in pregnant women during vaginal birth. it could be seen, that the application of the device significantly reduced the rate of vagibal tears and low-grade perineal tearsin the intervention group (with application of the babyslide®) in contrast to the controlo group (without application of the babyslide®) by about 10%. in this study, solely 10% of births were ended by vacuum assistance. however, birth tears appear much more often in vacuum-assisted births than in normal spontaneous births. therefore, the aim of this study is to evaluate the application of the device explicitly in vacuum-assisted births and to investigate if the application should be recommende in vacuum extractions in general in the future.


Eligibility criteria:
inclusion criteria: * schwangere frauen ab 18 jahren * schwangerschaftsalter ab 36+0 ssw bei geburt * einlingsschwangerschaft * schädellage des kindes bei geburt * anstreben einer vaginalgeburt am usz * geburtsbeendigung per vakuumextraktion (saugglocke) * schriftliche einwilligung der teilnehmenden person nach erfolgter aufklärung (ausreichende deutsch- bzw. englischkenntnisse) exclusion criteria: * - geburtsbeendigung per spontangeburt, forcepsextraktion (zange) oder sectio caesarea (kaiserschnitt) * maternale erkrankung des bindegewebes (z.b. kollagenosen) * äusserliche fetale fehlbildungen, die den geburtsablauf und die grössenverhältnisse von kind zu geburtskanal verändern * intrauteriner fruchttod des kindes * vaginale, perineale und/oder vulväre voroperationen (ausser naht von geburtsverletzungen) * st.n. beckenboden-operation oder inkontinenz-operation * st.n. infibulation * anwendung des epi-no® dammtrainers während der schwangerschaft * bekannte allergien gegenüber einem der inhaltsstoffe des babyslide®
cue exposure training for overweight children

Conditions: Overweight; Obesity

Summary: the primary objective of the study is to investigate the effectiveness of two intensive two-session trainings, the conventional psycho-education and food cue exposure, on eating in the absence of hunger, binge eating and body mass index (bmi) change in overweight/ obese children.


Eligibility criteria:
inclusion criteria: * being a patient in the maastricht university medical center coach unit for obese children and adolescents. * overweight, according to the sex and age specific cut-off point for overweight in children, as defined by cole and colleagues (2000). * age: 12 - 18 years exclusion criteria: * not being overweight (anymore, due to weight loss) * not able to speak and/or write dutch

Keywords: cue exposure childhood overeating overweight obese treatment
safety and tolerability of ain457 in adults (18-65 years) with moderate to severe ankylosing spondylitis

Conditions: Ankylosing Spondylitis

Summary: this study is designed as an extension study to the proof-of-concept trial cain457a2209 in patients with moderate to severe ankylosing spondylitis and aims to provide continuous treatment with ain457 for patients in the core trial, to obtain safety and tolerability information. the study will address the evaluation of efficacy following doses of intravenous infusion (iv) of 3 mg/kg ain457 given every 4 weeks over a period initially up to 6 months (part 1) and based on the risk/benefit balance of ain457 in ankylosing spondylitis a decision was taken to continue dosing for another 6 month period (part 2).


Eligibility criteria:
inclusion criteria: * patients who took part and completed in the core cain457a2209 study * patients who discontinued the core study due to unsatisfactory therapeutic effect at their visit 14 (week 16) or later could enter the extension study within 3 weeks of completing the study discontinuation visit of the core study, provided that at their discontinuation visit they fulfilled either one of the criteria below. patients who did not enter the extension study within 3 weeks of completing the study discontinuation visit of the core study, were required to come for an additional baseline visit (visit 17) and were required to fulfill either one of the criteria below: * no improvement (compared with the core study baseline) in two out of the following four domains: patient global assessment, pain, basfi and the mean of the two morning stiffness questions from the basdai. or * deterioration (compared with the core study baseline) in one of the four domains (deterioration defined as \>=20% worsening and an absolute worsening of \>=1 unit) exclusion criteria: * patients for whom continued treatment with ain457 is not considered appropriate by the treating physician. * patients who were non-compliant or who demonstrated a major protocol deviation in the core cain457a2209 study. * patients who discontinued from the core cain457a2209 study before visit 14 (week 16), and patients who completed the core study * pregnant or lactating women * presence of active infection * positive ppd or hiv test in patients where repeated testing was deemed appropriate due to their risk profile other protocol-defined inclusion/exclusion criteria may apply

Keywords: ankylosing spondylitis igg1k monoclonal antibody interleukin -17a neutralizing