Kornimate/medical-research-clean huggingface dataset:
endosseous oroantral port for minimal intervention in treating chronic sinusitis

Conditions: Maxillary Sinusitis

Summary: this study is intended to evaluate the efficiency of utilizing "dynamic implant valve approach" (diva) system in treating chronic maxillary sinusitis.

a prospective study aimed to test the efficiency of a minimal interventional approach in treating chronic maxillary sinusitis. the "dynamic implant valve approach" (diva), a minimally invasive approach utilizes a dental implant, designed with an internal sealing screw that might serve as drug delivery system via its channel. the implant is inserted to a posterior maxillary edentulous area, creating a connection between the sinus cavity and the oral cavity (oro-antral connection), hence, provides a controlled working channel for diagnosis and treatment of the disease (e.g; allowing drainage, lavage and sinus endoscopy). the implant is a medical device approved for use at the anatomical area of interest. the treatment method proposed in this study is based on the principle of a conventional treatment of washing the maxillary sinus cavity called "antral puncture and lavage". the changes that are proposed in this study could make the operation more convenient and effective in the therapeutic level, both for the patient and the clinician for the following reasons: * diva (dynamic implant valve approach) implant with a multi- useful working channel: the mere presence of the canal in the center of the implant with a screw seal, ensures controlled oro-antral connection, and enables multiple endoscopy and lavage procedures until resolution of the pathological condition is achieved. * the anatomical location of the puncture / penetration to the sinus - is performed in the maxillary edentulous region. this is the lowest area of the sinus cavity (standing or sitting posture), which utilizes gravity for drainage and extraction of the contaminated contents of the sinus. by appropriate advance planning, the implant, after eradication of the disease, can later be used for prosthetic purposes.

Eligibility criteria:
inclusion criteria: * no medical history of diseases involving bone metabolism * unilateral or bilateral maxillary sinusitis, as evident by radiographic and endoscopic modaleties, which have not responded to optimal conservative treatment * patient who is edentulous in the maxillary region and is interested in dental implant * the patient does not participate in another clinical study * the patient can read and understand the informed consent exclusion criteria: * medical history of increased risk of developing bone necrosis (mronj - medically related osteonecrosis of the jaw , or orn - osteoradionecrosis) * patients who are not interested or need dental implants * patients with maxillary sinus neoplastic pathology * chronic maxillary sinusitis with polyps * pregnant women

Keywords: diva sinusitis maxillary
palifermin for patients receiving hematopoietic stem cell transplantation

Conditions: Mucositis

Summary: the purpose of this study is to compare the efficacy and safety of palifermin on reducing mucositis for patients receiving autologous or allogeneic stem cell transplantation with supportive care.


Eligibility criteria:
inclusion criteria: * adequate organ function * patients who will receive autologous stem cell transplantation * patients who will receive allogeneic stem cell transplantation using myeloablative conditioning regimen exclusion criteria: * presence of concomitant malignancy * presence of active infection or oral mucositis prior to stem cell transplantation * any conditions where the severity of oral mucositis cannot be evaluated

Keywords: hematopoietic stem cell transplantation palifermin
assessment of polyethylene wear, migration and clinical outcome in total hip replacement

Conditions: Osteoarthritis, Hip; Osteoarthritis

Summary: the objective of the study is to investigate head penetration, cup migration, and clinical outcome in total hip replacements using a factorial design. treatment groups are e-poly versus arcomxl liners, and 36 mm versus 32 mm head size.


Eligibility criteria:
inclusion criteria: * primary idiopathic arthritis, * eligible for uncemented total hip arthroplasty * 40 to70 years of age, * cup size of 54mm and above exclusion criteria: * anteversion where non-standard stem can be used, * dysplasia (center-edge angle of wiberg \< 20°), * malignant condition * prior radiotherapy * physical or psychological condition that renders it impossible for the patient to take part in our usual rehabilitation programme (as stated in the department's standard operation procedure), * complications during surgery (requiring screws in shell or femoral cerclage)

Keywords: joint diseases musculoskeletal diseases radiostereometric analysis total hip arthroplasty
neurotensin - an important regulator of appetite in humans?

Conditions: Physiology - Regulation of Appetite and Food Intake

Summary: neurotensin (nt) is a gut peptide released postprandially from the small intestine. it is known to exert a range of enterogastrone effects and in animal models it reduces food intake when administered by parenteral routes. this study investigates whether the anorexic effects of nt suggested by animal studies can be translated.


Eligibility criteria:
inclusion criteria: * age = or above 18 years * normal haemoglobin levels * male * informed consent exclusion criteria: * diabetes mellitus (fasting plasma glucose or hba1c) * familiy history of diabetes mellitus * intestinal disease (incl e.g. inflammatory bowel disease and malabsorbtion) * family history of inflammatory bowel disease * previous intestinal resection * body mass index (bmi) over 25 kg/m2 * smoker * nephropathy (s-creatinine\> 130 μm) * liver disease (alat and/or asat \> 2 × upper normal limit)

Keywords: food intake appetite obesity treatment neurotensin gastrointestinal peptide
online memory intervention for individuals with traumatic brain injury

Conditions: Brain Injuries, Traumatic; Brain Injury Traumatic Severe; Brain Injury Traumatic Moderate; Brain Injury, Chronic

Summary: this study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe traumatic brain injury.

the memory impairments associated with moderate to severe traumatic brain injury can be debilitating to younger and older adults, and can prevent a person's return to work, school and social life. the "hippocampus" is a ubiquitously compromised memory brain structure in moderate-severe tbi. unfortunately, not only does the hippocampus sustain the damage at the time of injury, but researchers have identified that it shows continued atrophy in the months and years following injury. the investigators has developed a promising behavioural intervention for arresting this shrinkage, enhancing the integrity of the hippocampus - and improving memory function. it entails engagement in novel, continuous and challenging allocentric spatial navigation, that is, learning new routes of cities, and making a map in one's head of those routes for 1 hour/day, 5 days per week for a period of 16 weeks. n=87 participants will be randomized to either the intervention group or an active control group that will watch 3 tedtalk videos per day, 5 days a week for the same duration. an mri scan and cognitive measures focusing on memory and spatial navigation will be conducted before and after participation.

Eligibility criteria:
inclusion criteria: * acute care diagnosis of m-stbi * pta of 24 hours or more and/or lowest gcs \<13 * positive ct or mri; (4) between 18 to 55 years of age * fluency in english; (6) competency to provide informed consent or availability of a legal decision maker * basic computer skills (use of internet/email, mouse and arrow keys) * functional use of at least one upper extremity for computer use * resident of greater toronto area (to facilitate access to the mri). exclusion criteria: * neurological disorder other than tbi (e.g., dementia, stroke) * diagnosis of a neurodevelopmental disorder * tbi sustained before age 18 * systemic comorbidities (e.g., lupus, diabetes) * current diagnosis of aphasia * presence of metal inside the body (e.g., surgical clips, pacemaker) leading to ineligibility for an mri.

Keywords: environmental enrichment spatial navigation traumatic brain injury neurorehabilitation telerehabilitation hippocampus
prevalence of anxiety symptoms among french general practitioners

Conditions: Anxiety

Summary: mental health is a major public health issue in the general population, but few studies seem to focus on the mental health of self-employed healthcare professionals, and gps in particular. as front-line workers who are often called upon to manage complex situations, they are quite likely to suffer from anxiety-depressive symptoms or burnout. nevertheless, general practice is vast, and there are many different ways of practising and organising it.

the primary objective is to describe the prevalence of clinically significant anxiety symptoms in french self-employed gps. the secondary objective is to investigate the factors associated with the presence of clinically significant anxiety symptoms in french self-employed gps.

Eligibility criteria:
inclusion criteria: * general practitioners * qualified and established * practicing in france * with at least some self-employed practice * agreeing to participate in the study exclusion criteria: * salaried general practitioners

Keywords: anxiety self-employed gps prevalence
impact of oral versatile antioxidants on glaucoma progression

Conditions: Glaucoma

Summary: background: the significance of retinal ganglion cell protection in the glaucoma led the view that, glaucomatous optical neuropathy can also be considered as a pathology of central nervous system. it is known that α-tocopherol and gingko biloba have specific neuroprotective and vasoregulatory activities, in addition to antioxidant effects. in this study, the investigators compared early neuroprotective effects of α-tocopherol and gb with each other as well as control and a strong antioxidant formulation in patients with glaucoma. methods: in this non-randomized control trial, 120 eyes of 60 patients with glaucoma were enrolled into the study and divided into 4 groups, each consisting of 30 eyes. unlike the controls, patients in the 3 antioxidant groups received α-tocopherol, gingko biloba and a strong antioxidant formula for 3 months. central vision field and md, psd and oct as well as thickness of retinal nerve fiber layer, ganglion cell counts and c/d ratios were recorded. the data were compared statistically.

a significant difference was observed between md, psd, s-rnfl and m-rnfl levels of groups (p\ 0.05). while the difference between c/d levels of groups were highly significant (p\ 0.05). no statistically significant difference was present between s-gcc and i-gcc levels of groups (p\>0.05). a high statistically significant difference was found between m-gcc levels of groups (p\ 0.05).

Eligibility criteria:
inclusion criteria: * patients who received follow-up in our glaucoma polyclinics exclusion criteria: * known ocular or systemic concomitant disorders * previous glaucoma surgeries * antioxidant usage

Keywords: antioxidant α-tocopherol vitamin e gingko biloba glaucoma neuroprotection retina
light therapy for chronic insomnia in general practice

Conditions: Insomnia Chronic; Sleep Disorder; Circadian Rhythm Disorders

Summary: * sleep disorders, especially insomnia * attention deficits (or disorders), daytime somnolence and drug dependence * the goal is to evaluate whether light therapy could be used as an efficient alternative treatment with direct application in general practice

insomnia affects 15 to 20% of the general french adult population and increases with age. general practitioners (gps) are the first confronted to sleep disorders, especially insomnia. cognitive-behavioral therapies (cbt) have proven effective, but their implementation in everyday practice is limited, and alternative treatments are still needed. light not only has a great influence on the sleep-wake cycle and alertness, but also on mood and cognitive functions. the administration time of light condition will be calculated for each individual in a modality that has no impact on the circadian phase. study will be conduct on an outpatient basis in general practice

Eligibility criteria:
inclusion criteria: * complaining of chronic insomnia according to icsd-3 (international classification of sleep disorders) criteria and/or taking hypnotics at least 3 nights per week for more than 3 months. * non-hypnotic medication: stable medication during one month preceding the inclusion and for the 8 weeks of the study. * compliance with the treatment: the patient is able to have light therapy during the required time and at the agreed schedule. exclusion criteria: * severe psychiatric disorder (severe major depression, schizophrenia, bipolar disorder), obvious acute psychiatric comorbidity. * untreated intrinsic sleep pathology: sleep apnea syndrome based on clinical criteria: stop-bang questionnaire score, restless legs syndrome manifesting more than 2 times a week and/or requiring treatment. * mild to severe dementia. * neurodegenerative sleep troubles * severe intercurrent pathology. * ophthalmic troubles presenting a contraindication to light therapy: retinopathy, age-related macular degeneration, diabetic retinopathy, macular hole, epiretinal membrane); lens opacifications (cataract) justifying surgery (correction of poor visual acuity, visual discomfort); glaucomatous and non-glaucomatous optic neuropathy resulting in visual impairement. * toxicomania, chronic alcoholism. * secondary insomnia linked to somatic non-stabilized pathology. * elements influencing circadian rhythm * pregnancy, breastfeeding. * participation in another interventional clinical trial which includes an exclusion period * no information could be given to the patient (subject faces emergency situation, comprehension difficulties, etc.) * patient under guardianship * non hypnotic treatment potentially inducing a level 3 sleepiness one week before
self-sampling in women who do not undergo routine cervical screening

Conditions: Health Status Unknown; Precancerous Condition

Summary: rationale: women who do not undergo routine cervical screening may be more likely to collect a self-sample for human papillomavirus testing. purpose: this randomized clinical trial is studying self-sampling in women who do not undergo routine cervical screening.

objectives: * to ascertain whether women who do not attend for cervical screening are more likely to respond to the opportunity to collect a self-sample for human papillomavirus (hpv) testing, or to respond to a further invitation to undergo a cervical smear. * to ascertain whether such women will attend for further investigation if they have a positive screening test (hpv test or cervical smear). outline: patients are randomized to 1 of 2 arms. * control: patients receive an invitation for a routine cervical smear and a cervical screening survey. information regarding attendance for smear or colposcopy is collected at the primary care trust. * study (self-sampling kit): patients receive an explanatory letter, an information sheet about the study, a consent form, information about human papillomavirus (hpv) and hpv testing, a self-sampling test kit, and an invitation to take their own hpv sample and return it to the research group for processing. patients also receive a cervical screening survey. patients who attend for further investigation following a positive hpv result go to st. mary's hospital colposcopy unit, paddington. during this visit cervical smear tests are performed and women are offered immediate colposcopy so that they would not need to return for colposcopic examination if their smear test is abnormal. this study is peer reviewed and funded or endorsed by cancer research uk.

Eligibility criteria:
disease characteristics: * women in westminster primary care trust (pct) area eligible for routine cervical screening who have not responded to two invitations to attend for smears * no women who have written to the pct to document their refusal to take part in the national health service cervical screening program (nhscsp) * no women who are not due for routine screening as part of the nhscsp patient characteristics: * not pregnant * have been sexually active prior concurrent therapy: * no prior total abdominal hysterectomy

Keywords: human papilloma virus infection health status unknown
viral excretion in contact subjects at high/moderate risk of coronavirus 2019-ncov infection. covid-19.

Conditions: Coronavirus

Summary: in december 2019, a pneumonia due to a novel coronavirus (sars-cov-2) emerged in the city of wuhan, in china. in a few weeks, the number of confirmed cases of sars-cov-2 infection has dramatically increased, with almost 150'000 cases and more than 6'000 reported deaths on march, 16th 2020. little is known on the rate of human-to-human transmission of this new coronavirus sars-cov-2 in the community and within the hospital. depending on the country, contact subjects considered to be at high or moderate risk of sars-cov-2 are, either isolated at home for a period of time defined by the health authorities or, on the contrary, continue their professional activity on the condition that they adopt measures to prevent transmission to those around them. in most european countries, healthcare workers adopt this second option. in all cases, it is most often recommended that contact persons monitor their state of health and communicate it to the persons dedicated to this action. whether such subjects become spreaders of the virus is not known, nor is the proportion of viral spreader who will develop a symptomatic infection.

procedures added by the research: phone calls for collection of reported symptoms. nasopharyngeal swabs for determination of the presence of sars-cov-2 detected by pcr. blood sampling for determination of the presence of sars-cov-2 igm or igg. saliva or blood sampling for whole exome sequencing of the subject.

Eligibility criteria:
inclusion criteria: 1. high/moderate risk contact with a laboratory-confirmed sars-cov-2 case; 2. within the 14 days following the last contact with a laboratory-confirmed sars-cov-2 case; 3. obtaining informed consent. exclusion criteria: * subject deprived of freedom * subject under a legal protective measure

Keywords: contact subject high/moderate risk of transmission
chamas for change: impact of the covid-19 pandemic

Conditions: Gender Equity

Summary: in kenya, the chamas strategy (a peer support approach aimed at improving mnch and reducing gender and social inequalities) has been shown to significantly improve maternal and child health outcomes while also providing social and financial support to participating women. however, the covid-19 pandemic caused significant disruptions in women's work and mnch services around the world due to reallocation of health care resources, covid-19 fears, transportation restrictions, and lockdowns. these consequences appeared to disproportionately affect the poor, particularly poor women. the purpose of this participatory action design study is to determine how chamas participation intersected with other factors to mitigate the effects of the covid-19 pandemic on the health and economic well-being of women and children.

the study objectives are: to evaluate the effect of chama participation on mitigating the effects of the pandemic on social and gender equity. * impact on economic status (assessed using the changes in the poverty probability index scores) * impact on health service utilization and behaviours (assessed using enrollment in the national health insurance scheme, number of anc visits attended, facility delivery, maternal death, newborn death, infant death, exclusive breastfeeding, number of children fully immunized at age 1) * social attitudes and well-being (assessed using, attitude towards harsh punishment of children, level of parental stress) * covid-19 related information (assessed using covid-19 infection, covid-19 vaccination, and effects of covid restrictions) to use an equity-centered design process and narrative approach to share research findings. the research team intends to evaluate women's experiences during the pandemic using a mixed method approach and a participatory action design method. the focus will be on 3 study cohorts: (1) women who participated in chamas throughout the pandemic, (2) women who left chamas during the pandemic, (3) women whose communities were randomized to not receive the chamas intervention. to better understand the effects of chama participation on study outcomes, we will conduct an interviewer-administered survey among the described cohorts of women. this will be followed by qualitative studies to contextualize the study findings and investigate gender dynamics as social processes. focus group discussions (fgds) and key informant interviews (kiis) will be conducted to further investigate our study cohort's experiences during the pandemic and identify strategies used by participants to mitigate the negative effects of the pandemic and its associated restrictions.

Eligibility criteria:
inclusion criteria: * women who participated in the 2021 chamas study in western kenya exclusion criteria: * women who did not participate in the 2021 study.

Keywords: participatory research gender equity maternal and child well-being kenya mixed-methods