Kornimate/medical-research-clean huggingface dataset:
orthodontic extrusion of high risk impacted mandibular third molar

Conditions: Inferior Alveolar Nerve Injuries

Summary: the goal of this clinical trial is to investigate the usage of maxillary miniscrew and cross-arch elastics for the orthodontic traction of the impacted mandibular third molar in close proximity to the inferior alveolar nerve to decrease the chance of nerve injury

to investigate the traction of the impacted mandibular third molar away from the inferior alveolar nerve by using the orthodontic miniscrew in the maxillary bone and cross-arch elastic power chain as a temporary anchorage device before extraction to avoid injury of the nerve and neurosensory complications.

Eligibility criteria:
inclusion criteria: * patients with impacted mandibular third molar in close proximity to the inferior alveolar nerve. * cooperative patients free of chronic diseases which interfere with needed results (e.g.diseases affect the bone regeneration ). * patients with good oral hygiene. exclusion criteria: * patients with limitation in mouth opening. * patients with mental or physical disabilities. * allergy to anaesthetic components or antibiotics.

Keywords: orthodontic extraction impacted third molar tad
pet imaging of natriuretic peptide receptor c (npr-c) in carotid atherosclerosis

Conditions: Carotid Atherosclerosis

Summary: to demonstrate feasibility of imaging cu\[64\]-25%-canf-comb uptake in the atherosclerosis of the carotid artery of patients for whom carotid artery endarterectomy surgery is planned in comparison to the carotid artery for which intervention is not planned.

this study is a single center, open-label baseline controlled imaging study designed to demonstrate feasibility of pet imaging of radiopharmaceutical nanoparticle cu\[64\]-25%canf-comb uptake by pet-mr. patients will undergo cu\[64\]-25%canf-comb pet-mr imaging of both carotid arteries. both carotid arteries will be imaged at the same time. we hope to demonstrate differences in pet suv (standardized uptake value) in the significantly atherosclerotic artery in patients who will be going to carotid endarterectomy surgery in comparison to the pet suv in the artery that is not significantly diseased (ie; the artery that will not undergo surgery) . we also will determine whether pet suv of the cu\[64\]-25%canf-comb by the plaque correlates to the american heart association classifications of atherosclerosis and tissue presence of npr-c in the ex vivo carotid endarterectomy specimen post surgery as measured by rt-pcr.

Eligibility criteria:
inclusion criteria: * patients with carotid atherosclerosis * patients must be scheduled for carotid intervention (endarterectomy surgery) * signed informed consent. exclusion criteria: * unstable clinical conditions * pregnancy and lactation * inability to lie still for up to 60 min with arms down at sides for pet-mr imaging * unwilling to comply with study procedures and unavailable for the duration of the study. * pacemakers, brain aneurysm clip, shrapnel and other typical contraindications for mri imaging. * inability to provide written informed consent.

Keywords: carotid atherosclerosis, pet imaging agent
determination of the optimum cut-off value of type 2 diabetes diagnosis among chinese population(sensible study ii)

Conditions: Type II Diabetes

Summary: study of the correlation between agesp and hba1c and diabetic retinopathy prevalence: determination of cut-off value of agesp and hba1c in type 2 diabetes diagnosis in china

to find the cut-off point of agesp and hba1c for diagnosis of diabetes by drawing the logistic regression model between prevalence of retinopathy and agesp level and hba1c level,and find the point where the prevalence of retinopathy changes most rapidly.

Eligibility criteria:
inclusion criteria: * 20\~70 years old; * volunteer to participate in this study and signed informed consent. exclusion criteria: -

Keywords: glycosylated haemoglobin advanced glycation end products
a remote physical activity program in the population suffering from type 1 myotonic dystrophy

Conditions: Myotonic Dystrophy Type 1 (DM1)

Summary: the covid-19 pandemic exacerbates health problems by reducing access to adapted and advanced physical rehabilitation for several people who need rehabilitation services, including the population with myotonic dystrophy type 1 (dm1). the pace tool, an innovative web tool integrating pragmatic physical activity programs, seems to be an interesting and innovative intervention to counter physical deficiencies of people with dm1, which are unfortunately accentuated by the pandemic, while reducing the risk of covid-19 exposure. objectives: 1) evaluate the feasibility, usability and acceptability of the pace tool in the dm1 population; 2) evaluate the effects of the intervention on their physical and cognitive health; and 3) estimate the cost-effectiveness ratio of this intervention. method: sixty people (experimental group = 40 and control group = 20) will participate in this randomized intervention study. participants in the experimental group will be assigned to one of the 35 physical activity programs adapted to their condition of the pace tool. the program must be performed on a daily basis for a period of 12 weeks. physical and cognitive health will be assessed before and after the remote intervention via zoom, for all participants.


Eligibility criteria:
inclusion criteria: * dm1 diagnosis must be confirmed by genetic analysis (juvenile, adults or late-onset phenotypes); * aged between 18 and 60 years old; * be able to do exercise; * subjects must be able to give their consent freely and voluntarily. exclusion criteria: * patients who already train (\>3 times per week or \>150min/week); * don't speak french or english; * are not able to do exercise (even in sitting position);

Keywords: myotonic dystrophy type 1 physical activity function balance mobility
enhancing dialysis adequacy: effects of intradialytic exercise

Conditions: Chronic Kidney Disease

Summary: the purpose of this study is to investigate whether intradialytic exercise increases removal of waste products from blood, in comparison to the traditional prescription of increasing dialysis duration.

for patients with severe chronic kidney disease, regular dialysis to remove toxins and waste products from the blood is essential to maintain life. the adequacy of dialysis is quantified by the removal of these toxic solutes and is an important parameter in the assessment of the therapy. previous efforts to enhance urea clearance have centered around factors such as increasing dialysis dose by increasing dialysis time or carrying out more frequent dialysis sessions. however this concept is confronted with the barriers of patient compliance and cost implications. many patients are resilient to increasing their dialysis time, presenting a major challenge for enhancing the efficacy of dialysis therapy. therefore, alternative methods of improving dialysis adequacy, with interventions aimed at enhancing solute clearance, are highly warranted. one such intervention could be exercising during haemodialysis (hd). 85% of the body is comprised of lean tissue, of which 73% is water. as many toxic solutes are water based, large amounts will be stored in the muscle. when sitting at rest during hd the blood flow to the muscles is four times less compared to the major organs. additionally, the hd process causes blood vessels to constrict, further restricting blood flow to the muscle. consequently there is insufficient blood flow to remove the toxins stored in the muscle. by exercising during dialysis, blood flow to the muscle is increased to sustain the demand for oxygen and energy, thereby allowing toxic solutes to be removed and cleared through the dialysis machine. therefore the aim of this study is to implement an efficient exercise intervention during dialysis and determine its effects on dialysis adequacy in comparison to the traditional prescription of increased dialysis time. in particular, the study aims to explore the acute effects of exercise during dialysis on the removal of several established uremic toxins.

Eligibility criteria:
inclusion criteria: * stage 5 chronic kidney disease * receiving maintenance haemodialysis for \> 3 months exclusion criteria: * unable to give consent * present with contraindications to take part in exercise * haemoglobin \<11 g/dl * access recirculation * chronic persistent hypotension with pre dialysis systolic blood pressures \<100mghg. * episodic treatment induced hypotension with frequent drops in intradialytic systolic blood pressure \>30mmghg * unstable medical condition * currently taking medication affecting urea or creatinine generation

Keywords: dialysis adequacy urea clearance phosphate clearance beta 2 microglobulin clearance intradialytic exercise haemodialysis patients
serum free light change in multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of this study is to evaluate the predictive role of free kappa/lambda ration in multiple myeloma post-transplant.


Eligibility criteria:
inclusion criteria: * patients affected with multiple myeloma who underwent autologous or auto/allogenic stem cell transplantation.

Keywords: total kappa and lambda ratio stem cell transplantation serum immunofixation
quality of life after routine nasogastric decompression after distal gastrectomy for gastric cancer patients

Conditions: Gastric Cancer

Summary: the aim of the study is to evaluate whether distal gastrectomy without post-operative nasogastric decompression tube is better in terms of quality of life.

nasogastric decompression tube is an intra-operative routine in most of the time to facilitate exposure of operative field during elective distal gastrectomy, however, whether it should be retained post-operatively is controversial. nasogastric decompression tube helps to drain the gastric remnant in case there is edema around the gastrojejunostomy, ileus and delayed gastric emptying, which can theoretically relieve nausea and abdominal distension. however, nasogastric intubation could cause patients discomfort; also it has been shown that it would cause gastroesophageal reflux which may be associated with pulmonary complication.

Eligibility criteria:
inclusion criteria: * on the basis of whether distal gastrectomy was anticipated at wmuh for gastric cancer. exclusion criteria: * patients who were diagnosed inadequacy for this study by a physician. * patients without an informed consent.

Keywords: distal gastrectomy quality of life
glucose and insulin responses to test foods

Conditions: Glucose Response; Insulin Response

Summary: in this study, postprandial glucose and insulin responses of different foods will be measured in individuals with varying body weight.


Eligibility criteria:
inclusion criteria: * participants will be non-smoking males or non-pregnant females aged 20-45y, with normal glycemia and in good health. a total of 12 participants will be included, where approximately half will be male \& half female, and half normal weight (bmi \> 19.0 and \ 25.0 and \< 30). thus, no fewer than 5 male, 5 female, 5 normal weight and 5 overweight but not obese subjects will be included. additional inclusion criteria will include: * absence of diabetes, impaired glucose tolerance and impaired fasting glucose, defined as having a fasting plasma glucose \< 5.6 mmol/l (100 mg/dl) and plasma glucose levels \< 7.8 mmol/l (140 mg/dl) 2h after consumption of a 50 g glucose drink (ogtt will be administered during the screening visit) * systolic blood pressure 100-150 mmhg inclusive * diastolic blood pressure 60-90 mmhg inclusive * resting heart rate 50-90 beats/min inclusive after 3 minute rest * able to refrain from eating legumes and drinking alcohol the day before each test session * fasting triglycerides \< 2.0 mmol/l (178 mg/dl) * fasting hdl cholesterol \> 0.9 mmol/l (35 mg/dl) for males and \> 1.1mmol/l (42 mg/dl) for females * fasting ldl cholesterol \< 5.0 mmol/l (193 mg/dl) * ast and alt \< 120% of upper limit of normal (uln) * hscrp \< 10 mg/l * urea and creatinine \< 150% uln exclusion criteria: * failure to meet any one of the inclusion criteria * age less than 18 or over 45 years * known history or aids, hepatitis, diabetes or a heart condition * participants using medications or with any condition which might, in the opinion of dr. wolever, the president of gi testing, either: 1) make participation dangerous to the subject or to others, or 2) affect the results * participants who cannot or will not comply with the experimental procedures or do not follow gi labs safety guidelines. * food allergies of any kind * general anaesthesia in the month prior to inclusion. * smokers
long-term outcome following laparoscopic supracervical hysterectomy performed with and without excision of the endocervix in a reverse cone pattern

Conditions: Vaginal Bleeding

Summary: the occurrence of persistent vaginal bleeding following laparoscopic supracervical hysterectomy (lsh) is reported in the wide range of 0 % - 25 %. experienced gynaecologists have claimed that removal of any remaining endometrium in a reverse cone pattern at the time of the hysterectomy reduces the occurrence of persistent vaginal bleeding to a minimum. the effect of this particular technique has not been reported. ullevaal university hospital have developed an unipolar electrode for this study (lapcone electrode, mod. uus, l: 25cm, 6x10, art. no. rem-270, ross electro medical ltd, unit k1\&k2, quarry fields estate, mere, wiltshire ba12 6la, london, uk). the electrode is ce approved. outcome: 1.occurrence of vaginal bleeding 12 months after the procedure. 2. patient satisfaction 12 months after the procedure (10-point analogue scale). design: prospective randomised trial. methods; the study participants are randomised to laparoscopic supracervical hysterectomy performed by perioperative electrocoagulation from the upper cervical canal (n=70) or performed by excision of the endocervix in a reverse cone pattern followed by electrocoagulation of the upper cervical canal (n =70).


Eligibility criteria:
inclusion criteria: * all premenopausal women who are referred to the departement due to a benign condition requiring hysterectomy and who have given informed consent are eligible for study recruitment exclusion criteria: * women who are unable to communicate in written norwegian or oral english language. * woman with a previous history of cervical dysplasia, with cellular changes suggestive of dysplasia in preoperative smear or wtih atypical hyperplasia og malignancy in preoperative endometrial biopsy * women who after a thorough clinical evaluation are found to be more suited for vaginal, abdominal or total hysterectomy * women with a coexisting condition requiring no remaining ovaries after the procedure * postmenopausal women * women using hormone therapy (ht)

Keywords: laparoscopic supracervical hysterectomy vaginal bleeding patient satisfaction vaginal bleeding after laparoscopic hysterectomy
food as medicine: a quasi-randomized control trial of healthy foods for chronic disease management

Conditions: Obesity; Hypertension; Pre-diabetes; Type 2 Diabetes

Summary: the purpose of this study is to investigate the effect of providing healthy foods and nutrition education on participants' body weight, blood pressure, and average blood sugar level. the healthy food offerings tested in this study will help determine which option is best to improve health outcomes among cleveland clinic akron general patients with chronic conditions. findings from this study could guide doctors in deciding on appropriate nutrition and dietitian services for cleveland clinic patients.

participants will receive healthy food items for 15 weeks and nutrition counseling and education to support chronic disease management at no cost. the healthy food items will consist of either medically-tailored pre-prepared meals, or a weekly produce box with recipes depending on the study arm. participants must complete a baseline study visit, one nutritional counseling session via phone, 2 to 4 nutrition education videos, and a 16-week post-intervention study visit.

Eligibility criteria:
inclusion criteria: * adults 18 years of age or older who are patients at akron general center for family medicine * have body mass index (bmi) equal to or greater that 30kg/m2 and * have at least one of the following diagnoses determined based on patients' problem list in the electronic medical record (emr) and the international classification of diseases, 10th revision (icd-10) codes: 1. pre-type 2 diabetes mellitus 2. type 2 diabetes mellitus 3. hypertension * have not participated in nutrition counseling at the university of akron nutrition center within the past 6 months exclusion criteria: * food allergies * pregnant * no access to internet * need english language interpretation * currently participating in a structured weight loss program or using weight loss medications * any condition that, in the investigator's judgement, interferes with the ability to adhere to study requirements.
bioimpedance spectroscopy in humans during acute fluid volume expansion with different crystalloid solutions

Conditions: HEALTHY

Summary: the objective of the study is to identify a pattern of bioimpedance in humans during acute food changes. as a part of this study the investigators will be administering sodium bromide in oder to measure extracellular water via the bromide dilution technique.

the resistance of the human body to the flow of alternating current is thought to be related to the volume of fluid within the body. the acute change in fluid status of the human body alters the body resistance. this change can be measured accurately with bioelectrical impedance and previous experiments confirmed this observation. however, previous experiments using a piglet model and subsequently humans, suggested that the changes observed is a result of changes in salt instead of body water. an experiment has shown that bioimpedance analysis (bia) was able to detect changes in total body resistance when different electrolyte solutions were infused. the changes in resistance were related to changes in osmolarity and electro-ionic state, not to volume of water infused. therefore, bia measures principally the electro-ionic state. thus a measurement of fluid volume can be indirectly obtained from bia. however, in the non-steady state such as acute fluid volume expansion, the measurement of water volume cannot be performed accurately. in this study, we will be administering sodium bromide in oder to measure extracellular water via the bromide solution technique. despite the interesting observations, the human study described above was underpowered. therefore, we aim to validate the observations that have been previously made through carrying out an appropriately powered study with an adequate sample size to validate the observations noted.

Eligibility criteria:
inclusion criteria: * age \> 18 years * otherwise healthy with no medical history of: cardiac disease, renal disease, chronic liver disease, diabetes, or lymphedema exclusion criteria: * allergy to bromide * breast feeding mothers * pregnancy * heart failure * presence of a pace maker * renal failure * any contraindication to fluid bolus * recent or continued exposure to bromide containing drugs

Keywords: bioimpedance analysis spectroscopy electrolyte sodium bromide extracellular water
application of standardized green channel treatment system for ischemic stroke in xi 'an

Conditions: Acute Ischemic Stroke; Thrombolysis; Endovascular Treatment

Summary: objective: to observe the practical application of the standardized green channel treatment system for stroke in xi 'an in the real world. methods: clinical data and information of patients with acute ischemic stroke who received standardized green channel treatment for stroke were collected, and a multicenter observational clinical study was carried out in the real world to evaluate the prognosis, mortality, incidence of asymptomatic and symptomatic cerebral hemorrhage, incidence of pneumonia, and recurrence rate of stroke after 90 days.

the standardized green channel treatment system for acute ischemic stroke includes: triage nurse triage timely, rapid assessment emergency doctor, suspected stroke the green channel, immediately start in the green channel of stroke accompanied by doctors and nurses stroke patients improve ct examination, intravenous thrombolysis or ct room, emergency room if considering large vascular lesions and the onset time in 6 hours, and rapidly to international for endovascular treatment, if the onset time of more than 6 hours, rapid evaluation of ischemic penumbra and vascular occlusion by multi-mode imaging. if there are indications for endovascular treatment, go to the cath room for endovascular treatment as soon as possible.

Eligibility criteria:
inclusion criteria: * 18 years old; * consistent with the diagnosis of acute ischemic stroke; * 24 hours from onset to enrollment; * informed consent exclusion criteria: * patients who refuse to receive intravenous thrombolysis or intravascular intervention (including intravascular mechanical thrombolysis and arterial thrombolysis); * stroke patients caused by brain tumor, brain trauma and blood diseases; * those with a history of stroke and sequelae affecting the outcome assessment, namely, mrs 2 points before the onset of this stroke; * combined with claudication osteoarthritis rheumatoid arthritis gout arthritis and other limb dysfunction and affect the neurological function examination; * patients with severe hepatic and renal insufficiency (note: hepatic insufficiency refers to alt or ast values greater than 2 times the upper normal limit; renal insufficiency refers to blood creatinine value greater than 2 times the normal upper limit); * suffering from other serious life-threatening diseases with an expected survival time of less than 3 months; * other diseases that limit neurological function evaluation or affect patient follow-up; * a woman planning to be pregnant or breastfeeding; * currently participating in other clinical trials; * refuse to participate in the registration of investigators