Kornimate/medical-research-clean huggingface dataset:
drug treatment for alcoholics with bipolar disorder

Conditions: Alcoholism; Bipolar Disorder

Summary: the purpose of this study is to test the effectiveness of sodium valproate (depacon) in treating individuals with alcohol dependence and comorbid bipolar disorder.

the aim of this study is to test the mood stabilizer, anticonvulsant, sodium valproate in individuals with alcohol dependence and bipolar disorder, in a double-blind, placebo-controlled, and randomized trial of 6 months duration. all subjects are treated with treatment as usual, which include lithium carbonate and individual dual recovery counseling and are randomized to either sodium valproate or placebo.

Eligibility criteria:
inclusion criteria: * meets the criteria for alcohol dependence with comorbid bipolar disorder. * agreement to participate in outpatient treatment. * ability to tolerate lithium carbonate and be randomized to receive sodium valproate or placebo. * stable living situation. * ability to provide informed consent. exclusion criteria: * psychiatric conditions including schizophrenia, schizoaffective disorder, any non-bipolar psychotic disorder, unipolar major depression, mental retardation, or signs of impaired cognitive functioning. * neurological conditions including epilepsy, history of brain injury, encephalitis, or any organic brain syndrome or focally abnormal electroencephalographic examination. * medical conditions including severe cardiac, liver, kidney, endocrine, hematologic, other impairing or unstable medical condition or impending surgery. * persistent elevation of liver function enzymes indicating active liver disease. * pregnancy or not using an acceptable contraceptive method. * inability to read or understand study forms; agree to informed consent. * impending incarceration or a mandate to attend treatment by the legal system for an alcohol use disorder. * the presence of either/or cocaine dependence, opioid dependence, and intravenous drug use.
endovascular repair of aaa

Conditions: On Abdominal Aortic Aneurysms

Summary: we study differen t endovascular techniques as an alternative to surgical reconstruction to repair aaas regarding ; success rates, 30-day mortality, endoleak events secondary intervention rates


Eligibility criteria:
inclusion criteria: * older than 18 exclusion criteria: * inflammatory or mycotic aaa
a study of rta 402 in obese adults

Conditions: Obese Adult Male

Summary: to investigate changes in body weight and body composition in obese adults after repeated oral administration of rta 402 once daily for 16 weeks, using placebo as a control.


Eligibility criteria:
inclusion criteria: * written voluntary informed consent to participate in the study * male aged ≥ 20 and \< 50 years at the time of consent * bmi ≥ 25.0 kg/m2 measured at screening * waist circumference (umbilical position) ≥ 85 cm measured at screening. * mri-measured visceral fat area ≥ 100 cm2 measured at screening exclusion criteria: * subjects who have undergone weight control procedures (weight loss medicine, surgical therapy, exercise therapy, bariatric diet, etc.) at a medical institution within 3 months before the screening * subjects with conditions requiring treatment other than obesity * history of cardiac failure (e.g., a prior diagnosis of congestive cardiac failure defined as nyha class iii or iv or a history of hospitalization for cardiac failure)

Keywords: bardoxolone methyl obese adult body weight body composition
to assess the efficiency and satisfaction of pharmacist giving patient-centred advice on telephone consultation in tb patients: experience of the covid-19 pandemic

Conditions: TB - Tuberculosis; Patient Satisfaction

Summary: the covid-19 pandemic might be an opportunity to review and refine our practices in anti tb treatment. for the follow-up of selected patients, telephone consultations may be efficient and cost-effective. the aim of the study is to assess the efficiency and the satisfaction with telephone consultation for the pharmacist and the tb patient. the study was conducted in tertiary care hospital tb control centres patients.

tuberculosis (tb) is the world's biggest killer among infectious diseases, claiming more than 4000 lives each day. the unprecedented coronavirus pandemic seriously impacts people with pre-existing health conditions. people who have tb are usually more vulnerable to other infections, including the novel coronavirus, due to pre-existing lung damage. they are at a higher risk of developing complications from covid-19. certain populations are at greater risk of tb, because of where they live, where they work or because of other socio-economic factors which result in them experiencing barriers to accessing health services.

Eligibility criteria:
inclusion criteria: new, smear-positive drug-susceptible tb who have been on treatment for less than two weeks access to a mobile phone (self-reported) exclusion criteria: patients who do not have regular access to a mobile phone patients who have previously received tb treatment patients who have another member in their household who is already a part of the study
determination of a questionnaire after treatment with pantoprazole at full dose and half dose in adult patients with symptoms of acid reflux (gastroesophageal reflux disease) (by1023/uk-506)

Conditions: Gastroesophageal Reflux; GERD; GORD

Summary: gastroesophageal reflux disease (gerd) is a medical condition affecting the stomach and esophagus. gerd occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the esophagus. gerd is one of the most common medical disorders, with estimates of up to 50% of adults reporting reflux symptoms. proton pump inhibitors such as pantoprazole, can relieve symptoms of gerd in a large proportion of patients. of particular interest in gerd is the assessment of symptom severity and quality of life, and the response to treatment. therefore, a questionnaire was developed to assess gerd symptoms ('request trademark in practice'). an important point to consider when using such a questionnaire is to follow the patients´ medical response to treatment and note whether a patient needs to change dosing, such as changing from full dose to half dose, or vice versa. the aim of the study is to determine the value of the questionnaire ('request trademark in practice') according to treating physicians' clinical judgment when using pantoprazole at full and half dose. the study duration consists of a pre-treatment periods (0-2 weeks) and two treatment period (8 weeks each). during the first treatment period, pantoprazole will be administered once daily at full dose (40 mg). during the second treatment period, pantoprazole will be administered once daily at half dose (20 mg). the study will provide further data on safety and tolerability of pantoprazole.


Eligibility criteria:
main inclusion criteria: * written informed consent * outpatients of at least 18 years of age * gerd * patients with symptoms of gerd main exclusion criteria: * signs, indicating other gastrointestinal diseases * other concomitant diseases * special restrictions for female patients * previous medication * concomitant medication

Keywords: gastroesophageal reflux gastroesophageal reflux disease pantoprazole
hfno combined with npa reduces hypoxia during sedated gastrointestinal endoscopy in obese patients

Conditions: Gastric Cancer; Gastric Ulcer; Intestinal Cancer; Intestinal Polyps

Summary: obesity is associated with adverse airway events including desaturation during deep sedation. previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of hypoxia during sedated gastrointestinal endoscopy in non-obesity patients. the prerequisite of high-flow nasal oxygenation is keeping airway patency. our pervious study demonstrated that nasopharyngeal airway has the similar efficacy of jaw-lift. in present study we aimed to determine whether high-flow nasal oxygenation combined with nasopharyngeal airway could reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in obese patients.


Eligibility criteria:
inclusion criteria: 1. patients receiving selective combined upper intestinal and lower intestinal endoscopy procedure under deep sedation. 2. age ranging from 19 to 80, both male and female 3. obese patients，bmi ≥ 28kg/m\^2 4. asa i\~iii 5. patients should clearly understand and voluntarily participate in the study, with signed informed consent. exclusion criteria: 1. patients with acute respiratory infection in the last 2 weeks 2. patients with nasal congestion, epistaxis, recent nasal trauma, recent nasal surgery 3. hypoxia, defined as oxygen saturation measured by pulse oximetry (spo2) ≤ 95% before preoxygenation. 4. common advanced gastrointestinal endoscopy procedures meeting eligibility criteria included cholangiopancreatography, endoscopic ultrasound procedures, endoscopic mucosal resection and endoscopic retrograde cholangiopancreatography (ercp) procedures. 5. coagulation disorders or platelets \< 100\*10\^9/l 6. have serious heart diseases such as severe arrhythmia, heart failure, adams stokes disease, unstable angina pectoris, myocardial infarction in the last 6 months, history of tachycardia / bradycardia requiring medical treatment, third degree atrioventricular block or qtc interval ≥ 450ms (corrected according to fridericia's formula), or exercise tolerance \< 4mets 7. allergy to eggs, soy products, opioids and other drugs, propofol, etc. 8. participated in other clinical trials as a subject within 3 months 9. patients with brain injury, possible convulsion, myoclonus, intracranial hypertension, cerebral aneurysm, cerebrovascular accident history, schizophrenia, intellectual disability, mania, psychosis, long-term use of psychotropic drugs, drug addiction, cognitive dysfunction history, etc. 10. emergency procedure 11. pregnant or breast-feeding women 12. patients having procedures with planned tracheal intubation or laryngeal mask 13. investigator considers the patients are inappropriate to participate in this trial

Keywords: high-flow nasal oxygenation gastrointestinal endoscopy hypoxia
cognitive control of negative stimuli in bpd

Conditions: Borderline Personality Disorder

Summary: borderline personality disorder (bpd) is characterized by impairments in the cognitive control of negative information. these impairments in cognitive control are presumably due to blunted activity of the dorsolateral prefrontal cortex (dlpfc) along with enhanced activations of the limbic system. however, the impact of an excitatory stimulation of the dlpfc still needs to be elucidated. in the present study, we therefore assigned 50 patients with bpd and 50 healthy controls to receive either anodal or sham stimulation of the right dlpfc in a double-blind, randomized, between-subjects design.


Eligibility criteria:
inclusion criteria borderline personality disorder: * diagnosis of borderline personality disorder exclusion criteria borderline personality disorder: * diagnosis of current or previous bipolar disorder * diagnosis of current substance dependency * diagnosis of current major depression * diagnosis of current or previous neurological disorders (e.g., epilepsy) * tattoos or scarred skin on the left shoulder or scalp (i.e. f4) inclusion criteria control participants: * no current or previous diagnosis of a mental disorder exclusion criteria control participants: * more than 2 criteria of borderline personality disorder are met * diagnosis of current or previous neurological disorders (e.g., epilepsy) * intake of psychotropic medication * tattoos or scarred skin on the left shoulder or scalp (i.e. f4)
does lung impedance correlate with changes in bnp in stable and acutely decompensated heart failure patients?

Conditions: Congestive Heart Failure

Summary: the purpose of this study is to determine whether there is a relationship between serial b-natriuretic peptide (bnp) and implantable device measured intrathoracic impedance in symptomatic and asymptomatic heart failure patients over a 1-year period. furthermore, this study will establish whether implantable device measured intrathoracic impedance trends with the distance walked on a six-minute hall walk (6mhw), an exercise-based acute measure that has also been associated with heart failure clinical status.

this is a prospective non-randomized longitudinal study. one hundred subjects will participate in 6 monthly and 3 bi-monthly serial assessments of plasma-based bnp, implantable device measured intrathoracic impedance, and clinical evaluation of heart failure status. each patient will be enrolled in the study for a period of 12 months.

Eligibility criteria:
inclusion criteria: * baseline bnp \> 80 pg/ml * meets current guidelines for icd implantation with or without crt * receiving a medtronic insync sentry, concerto, virtuoso, or subsequently approved medtronic icd with the optivol feature. * walk \< 450 meters during 6 minute hall walk test exclusion criteria: * less than 18 years of age * life expectancy \< 6 months * history of non-compliance with clinic visits or study-related tasks which may decrease chance of completing of the study * physical disability which limits exercise

Keywords: congestive heart failure implantable defibrillators intrathoracic impedance
amyotrophic lateral sclerosis: a new paradigm

Conditions: Amyotrophic Lateral Sclerosis

Summary: amyotrophic lateral sclerosis (als) is a degenerative neuromuscular disease, progressing inexorably to respiratory failure, the by involvement of respiratory muscles, the commitment with most impact on the prognosis of als. according to current knowledge, the clinical presentation of the disease is characterized by spinal or bulbar involvement, the latter being associated with a worse prognosis. there are multiple factors described in the aetiology of als, as the successive damage the motor neuron, which can happen in high-impact athletes, or exposure to heavy metals. genetic mutations are also described, being associated to a higher prevalence of als. data from retrospective studies with als populations reveal a prevalence of 4-8 cases per 100,000 persons. research carried out in trás-os-montes e alto douro region (northeast of portugal) shows a high prevalence of als, with near 10 cases per 100,000 persons, with a recent increase in the bulbar involvement. the reasons for the high prevalence of als in this region are unknown.

the objective of this research is to pursue potentially involved genetic mutations in this disease (new or previously described), in addition to carry out a epidemiological questionnaire including data on personal history, environmental and occupational exposure that might be underlying this high prevalence.

Eligibility criteria:
inclusion criteria: * all patients with amyotrophic lateral sclerosis sent to a medical consultation exclusion criteria: * amyotrophic lateral sclerosis not confirmed * ages less than 18 years old

Keywords: amyotrophic lateral sclerosis bulbar disfunction rik factors als
cognitive behavioral vs. interpersonal therapy (ipt) prevention of depression in adolescents

Conditions: Depressive Symptoms

Summary: the purpose of this study is to evaluate the efficacy of a cognitive-behavioral vs. an interpersonal therapy program for preventing depressive symptoms in adolescents.

hypothesis -- the cognitive-behavioral and interpersonal therapy prevention programs will be significantly better than the no-intervention control group in preventing depressive symptoms measured at post-intervention and at the 6-month follow-up. gender differences also will be explored.

Eligibility criteria:
inclusion criteria: * all students in 9th grade wellness classes who have parental consent exclusion criteria: * students without parental consent

Keywords: depression adolescents prevention schools
the effect of cinacalcet on gastric acid output in healthy subjects

Conditions: Healthy

Summary: the purpose of this study is to determine whether cinacalcet will increase gastric acid secretion in healthy volunteers.

the calcium sensing receptor (casr) was originally found on parathyroid and renal cells and more recently it has been identified on cells that regulate gastric acid secretion (g cells and parietal cells). however, its role in regulating acid secretion in humans is completely unknown and is of potential importance because an acid environment in the stomach enhances intestinal calcium absorption. in this pilot project, we will stimulate the casr with a casr-agonist called cinacalcet. our hypothesis is that activation of the casr will in turn increase gastric acid production in healthy volunteers.

Eligibility criteria:
inclusion criteria: * healthy ambulatory men and postmenopausal women * age 45 to 70 * avoid alcohol, antacids, h2 blockers, proton pump inhibitors, or antihistamines during the study. exclusion criteria: * ionized ca++ level \ 5.02 mg/dl (normal reference range 4.18- 5.02). * 24-hour uca++ excretion \>350 mg. * cr \>1.3. * ast/alt values \>10% beyond reference range. * hgb level \<11.7 g/dl in women and \<13.2 g/dl in men. * mcv level \>102 um3. * basal acid output \>5 meq/h in men and \>3.8 meq/h in women. * basal acid output \<1 meq/h in men and \<0.2 meq/h in women. * age \ 70. * premenopausal or \<1 year post-menopause. * individuals following vegan diets. * current etoh abuse. * lidocaine allergy. medications * antacids * h2 blockers * proton pump inhibitors * carafate * anticholinergic agents (i.e. tca) * cholinergic agents * antihistamines in the last 3 weeks * cogentin * adrenergic blockers * thiazide diuretics * antiplatelet drugs * oral and inhaled glucocorticoids * bisphosphonates * raloxifene, tamoxifen * tobacco * etoh during study * rpth * calcitonin * ketoconazole/itraconazole * calcitriol * paricalcitol * drisdol, ergocalciferol * phosphate binders * anticoagulant * erythromycin * hormone replacement therapy except vaginal estrogen creams exclusion diseases * achlorhydria * pernicious anemia * zollinger ellison syndrome * congestive heart failure * esophageal strictures or motility problems * history of a gi bleed * prior upper gi surgery * malabsorption * history of gi malignancy * gerd, gastritis, duodenitis * active peptic ulcer disease * gallbladder disease * liver disease * pancreatitis * current kidney stone * renal disease * current hypoparathyroidism or hyperparathyroidism * moderate to severe coronary artery disease * aortic aneurysm * seizure disorder * current arrhythmia

Keywords: gastric acidity determination calcium sensing receptor
the effects of caffeine on physical performance of ice hockey players

Conditions: Caffeine; Athletic Performance

Summary: to date, only one study has evaluated the effect of caffeine supplementation on athletic performance in ice hockey players finding a lack of ergogenic effect. this lack of effect is surprising as caffeine has been suggested to be an effective and safe nutritional supplement to improve physical performance in both trained and untrained individuals. therefore, the aim of the present study is to evaluate the effect of acute caffeine ingestion (3mg/kg body mass). thirteen elite adult ice-hockey male players will perform specific ice hockey performance tests in two separate days. on both occasions players will ingest 330 ml of water with lemon powertabs isostar® (86 kcal / 19g of carbohydrates) tablets, which will include in one of these days 3 mg/kg body mass of anhydrous caffeine. players will perform a 35-m sprint, an agility test (weave agility - slalom with puck), and a reaction test.


Eligibility criteria:
inclusion criteria: * over 18 years, * male * play in the spanish ice hockey first division. exclusion criteria: * participants taking drugs containing ephedrine or antibiotics. * having suffered a musculoskeletal injury in the 3 months prior to the tests.
improving walking quality and quantity in osteoarthritis (iwalqq-oa)

Conditions: Knee Osteoarthritis

Summary: this study evaluates the feasibility of a mindful walking intervention for management of knee osteoarthritis. participants will be randomly assigned to receive one of two interventions i.e. mindful walking intervention or a self-care intervention.

people with knee osteoarthritis have low levels of physical activity, especially walking activity. they also walk with abnormal walking biomechanics that are associated with greater knee loading. therefore, it is important to increase the levels of walking activity in people with knee osteoarthritis, but also change their walking patterns to reduce knee loading. this study will last 12 months and participants will be randomized into 2 groups. for the first 6-months, half of the participants will attend sessions at a community location that include training in mindful walking technique. the other half will meet for the same frequency and duration at a community location for education on osteoarthritis and its management (focusing on symptom management, importance of physical activity, weight management, etc.). both groups will also receive a wrist-worn activity monitor and a smartphone application that they will use throughout the study. after 6-months all participants will be allowed to practice on their own. all participants will complete gait analysis, knee mri, questionnaires, physical function assessment at baseline and at 6-months. all participants will also complete questionnaires at 3,9, and 12 months. weekly physical activity and knee pain data will be collected using the mobile health technology for 12- months.

Eligibility criteria:
inclusion criteria: * age 50-80 years * bmi ≤40 kg/m2 * meet american college of rheumatology clinical and/or clinical+radiographic criteria for knee osteoarthritis * knee pain score ≥ 4 during last week * predominantly medial knee pain * predominantly medial knee radiographic osteoarthritis with or without radiographic patellofemoral osteoarthritis * ability to ambulate for a minimum of 20 minutes, without any assistive device * available for the study duration * own a smartphone * can speak and understand english exclusion criteria: * contraindications to exercise * using orthotics for knee pain such as knee braces, wedge insoles * knee injection in previous 3-months * currently receiving physical therapy for knee pain * planning major treatment for knee pain (e.g., physical therapy, surgery) in next 6 months * self-reported joint diseases like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, gout, etc. * self-reported total joint replacement in any lower extremity joint * self-reported neurological conditions like stroke, parkinson's disease, etc. * self-reported muscular disease like muscle dystrophy * self-reported musculoskeletal or neurologic conditions that affect gait.

Keywords: physical activity gait biomechanics mindfulness
preoperative s-1/ohp with radiation therapy for low-lying rectal carcinoma in neo-adjuvant setting

Conditions: Rectal Carcinoma

Summary: the purpose of this study is to assess the safety and efficacy of s-1 and oxaliplatin combined with radiation by phase i/ii study. the purpose of this study is as follows, * in phase i, to determine the dose limiting toxicities (dlts) and the maximum tolerated dose (mtd). * in phase ii, to evaluate the antitumor effect (pcr rate) and the safety .


Eligibility criteria:
inclusion criteria: 1. patients with confirmed locally advanced and non-metastatic rectal adenocarcinoma (clinical stage t3, anyn or t4, anyn) 2. possible to r0 resection 3. received no prior therapy 4. performance status (ecog) 0-1 5. normal organ and marrow function. 6. sufficient oral intake exclusion criteria: 1. history of serious allergic reaction 2. patients without serious complications such as sensory neurotoxicity or serious diarrhea (with watery stool). 3. female with pregnancy or lactation 4. have another malignancy in the past 5 years except early stage other cancer that cure by local treatment