Kornimate/medical-research-clean huggingface dataset:
engaging homeless youth in vocational training to meet their mental health needs

Conditions: Mental Disorder; Mental Health; Employment; Housing Problems; Social Support

Summary: this randomized controlled trial (rct) compared the efficacy between the social enterprise intervention (sei) and individual placement and support (ips) with homeless youth with mental illness. methods: non-probability quota sampling sampling was used to recruit 72 homeless youth from one agency, who were randomized to the sei (n=36) or ips (n=36) conditions.

in response to the limited use of rcts with homeless youth to test research-supported interventions, this study compares the efficacy and short-term outcomes of two interventions that combine employment and clinical services with homeless youth experiencing mental illness. the social enterprise intervention (sei) is a research-supported intervention using a group approach that engages homeless youth in paid employment as well as case-management and mental health services through involvement in an agency-run social enterprise. the individual placement and support (ips) model of supported employment is an individually focused, evidence-based intervention , which provides individuals with severe mental illness with customized, long-term, and integrated vocational, case-management, and clinical services to help them gain and maintain competitive employment. a randomized comparative efficacy trial of the short-term, nonvocational outcomes (depression, self-esteem, social support, housing stability) of the sei and ips was conducted over 20 months with 72 homeless youth at a homeless youth drop-in center in los angeles. this study answered two research questions: 1) do homeless youth with mental illness participating in an employment intervention integrated with clinical services (sei or ips) experience improvements in their a) mental health status (self-esteem and depression); b) housing stability, and c) social support; and 2) what are the differences between the sei and ips groups on mental health, housing stability, and social support outcomes between baseline and follow-up?

Eligibility criteria:
inclusion criteria: * age 16-24 * english speaking * primary clinical diagnosis in the past year (with at least one symptom in the past 4 weeks) using the disc-y interview for one of six mental illnesses (i.e., major depressive episode, mania/ hypomania, generalized anxiety, post-traumatic stress disorder, conduct disorder, and alcohol/substance use disorders * desire to work. exclusion criteria: * none
assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers

Conditions: Radiation-induced Mucositis of Oral Mucous Membranes

Summary: the purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.

patients with head and neck malignancy with inclusion criteria randomly divide in 2 groups and take the intervention.

Eligibility criteria:
inclusion criteria: - age \>15 * need of radiotherapy * at least half of the mouth in the field of radiation * dose 50 -70 gy * head \& neck malignancy exclusion criteria: * systemic disease * fbs \> 150 wbc \> 3000 * history of radiotherapy * need of chemotherapy * systemic disease

Keywords: propolis mucositis radiotherapy cancer
interaction of apelin and angiotensin in the human forearm circulation

Conditions: Heart Disease; Vasodilation

Summary: the apelin-apj system is a relatively new discovery. it has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. angiotensin has a powerful ability to cause blood vessels constrict and reduces their diameter. one of the actions of apelin is to cause blood vessels to relax and the investigators specifically wish test the hypothesis that apelin will cause blood vessels constricted by angiotensin ii to relax.


Eligibility criteria:
inclusion criteria: * \> 18 years old exclusion criteria: * lack of informed consent * age \< 18 years, * current involvement in other research studies, * systolic blood pressure \>190 mmhg or \<100 mmhg * malignant arrhythmias * renal or hepatic failure * haemodynamically significant aortic stenosis * severe or significant co morbidity * women of childbearing potential. * any regular medication * previous history of any cardiovascular disease

Keywords: renin angiotensin system
erector spina plane block vs serratus anterior plane block for postoperative mastectomy pain

Conditions: Mastectomy; Pain, Postoperative; Recovery Period, Anesthesia

Summary: the aim of this study is to compare the efficiency of serratus anterior plane block and erector spina plane block on analgesic consumption, postoperative pain and patient's satisfaction and recovery quality in patients undergoing mastectomy.

mastectomy may cause severe postoperative pain. there are several analgesic methods for postoperative pain management. serratus anterior plane (sap) block is an interfascial plane block which is performed into the fascial plane of serratus anterior muscle. it provides effective analgesia in anterior, posterior and lateral dermatomes of thorax. there are several studies about its analgesic efficacy for mastectomy pain. the erector spina plane (esp) block is another novel plan block which provides analgesia at multi-dermatomal area of the anterior, posterior, and lateral thoracic and abdominal walls. there are some studies about its effectiveness for postoperative mastectomy pain management. however, according to our best knowledge, there is no literature comparing the efficacy of esp block and sap block patients undergoing mastectomy.

Eligibility criteria:
inclusion criteria: * american society of score anesthesiologist i-ii-iii * elective modified radical mastectomy * 18-65 years old exclusion criteria: * neurological disease * coagulopathy disease or using anticoagulants * non-cooperative * allergic to one of the drugs used in the study * recurrent breast cancer * body mass index is above 35

Keywords: pain management quality of healthcare
effects of isometric versus isotonic exercise in female patients with osteoarthritis

Conditions: Osteoarthritis

Summary: to find out the effects of isometric versus isotonic exercise in female patients with osteoarthritis


Eligibility criteria:
inclusion criteria: * female patients with osteoarthritis age group of 35 to 60 exclusion criteria: * patients admitted in icu or hdu patients with any mental illness
dipeptide alanyl glutamine and postoperative insulin resistance in colon carcinoma patients

Conditions: Colon Carcinoma

Summary: rationale: it is well known that insulin resistance occurs after mediocre and intensive surgery, such as colon cancer surgery. disturbances in insulin action negatively affect the postoperative recovery, either by prolonging the capacity of the body to regain normal function, or by increasing the metabolic stress and the risk for complications. several studies have shown that focusing therapies on improving insulin resistance is successful. experimental studies have shown that antioxidant agents, like glutamine (a precursor of glutathione), improve insulin sensitivity. the hypothesis of this study is that perioperative parenteral or enteral administration of glutamine, given as the dipeptide alanyl-glutamine, will reduce or prevent postoperative insulin resistance in colon cancer patients. the study will also be focused on the different routes of administration, because of the expected differential metabolic effects. objective: the investigators' primary objective is to study whether intravenous or enteral administration of the dipeptide alanyl-glutamine will reduce or prevent postoperative insulin resistance in colon cancer patients. study design: a double-blinded, placebo controlled randomised, pilot study at the surgery department of the medical center alkmaar. study population: thirty patients of male gender and any ethnicity, who will undergo elective open abdominal colon surgery for colon cancer, aged 18-75 years. intervention: patients will receive dipeptide alanyl-glutamine intravenously or enterally, starting 24 hours prior to surgery, until 24 hours after surgery in the dosage of 0.5 g/kg/day, or saline (control group), for the same period of time. main study parameters/endpoints: the main study parameter is postoperative insulin resistance. secondary study parameters are lipolysis, oxidative stress and glucoregulatory hormones. muscle, liver and fat biopsies will be taken to study insulin sensitive as well as inflammatory pathways.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years * colon cancer patients scheduled for elective open abdominal surgery * capable of giving informed consent exclusion criteria: * patients who are participating in another clinical trial * unable to receive oral intake * major malabsorption disorder of the gut * patients with diabetes mellitus * bmi above 30 kg/m2 * use of certain medication: thyroid medication, corticosteroids, diuretic medication * known bleeding disorders or increased ptt and or aptt * any medical condition except for colon cancer

Keywords: dipeptide alanyl-glutamine insulin sensitivity intracellular signaling antioxidant/oxidant parameters lipolysis inflammatory response in the liver
near fatal asthma in children and young people

Conditions: Near Fatal Asthma

Summary: this study will report the frequency, risks factors, clinical care and estimate the future asthma risk of children and young people (aged 5-15 years) experiencing a delphi defined near fatal asthma (nfa) attacks in the united kingdom (uk) and republic of ireland (roi). a greater understanding of the frequency and risk factors associated with nfa could help support children and young people (cyp), parents and clinicians to identify and modify risk, both independently and through a resulting clinical care pathway and also develop future research to improve effectiveness of interventions. the study will explore both commonly identified clinical factors, but also for the first time describe in detail the variance in medical management (acute and intensive care) that could lead to future clinical trials and guideline development to standardise care. the study will also describe, through data-linkage, socio-demographic factors associated with nfa, to include pollution, pollen, weather, viral prevalence that could lead to better care for higher risk cyp. to encourage more consistent, less fragmented care following a near fatal asthma attack, the study will consider how care is provided subsequent to an nfa attack using british paediatric surveillance unit (bpsu) surveillance at 12 and 24 month follow up.


Eligibility criteria:
inclusion criteria: * a child/young person is considered to have experienced an episode of near fatal asthma if they meeting any one of the following: 1. any child aged 5-15 years surviving\* an acute episode of asthma, who when presenting self-ventilating with severe dyspnoea (e.g. inability to speak) and all the following features: 1. pulse oxygen saturation below 92% despite maximal oxygen therapy (i.e. 10-15l/min oxygen flow via non-rebreather mask) during acute presentation 2. ph \ =60mmhg or 8kpa 3. escalation to use of intravenous bronchodilator infusion 2. any child aged 5-15 years surviving\* an acute episode of asthma, who had a respiratory arrest and/or required cardiopulmonary resuscitation as part of their presentation. 3. any child age 5-15 years surviving\* an acute episode of asthma for which he/she was invasively ventilated. * surviving to hospital discharge exclusion criteria: * cyp not meeting the case definition will be excluded. an expert panel (consisting of three clinicians) will adjudicate borderline cases.
effectiveness of laser in treatment of ureteric stones.

Conditions: Ureteric Stone

Summary: ureteroscopic laser lithotripsy is becoming the most commonly utilized treatment for patients with ureteral stone. the holmium: yag laser is integral to the operation and is the preferred flexible intracorporeal lithotripsy. it is considered cost-effective and efficient choice in ureteroscopic lithotripsy on all types of stones. as in recent years, there has been increasing interest in examining the effect of varying the laser settings on the effectiveness of stone treatment. the objective of the study is to compare the fragmentation and dusting modalities utilizing holmium yag laser in ureteroscopy for ureteral stone treatment. it will be a randomized control trial (rct) in which 160 patients visiting sahiwal teaching hospital, sahiwal will be included. the patients will be divided into two groups. group-a patients will be treated with fragmentation modality utilizing holmium yag laser while group-b patients will be treated with dusting modality utilizing holmium yag laser. simple random sampling technique will be carried out. the patients' age, gender, stone number, stone laterality, stone location, ureteral condition, reteropulsion, stricture formation, stone clearance, operative time, hospital stay, presence of retropulsion and complications will be recorded. data will be collected through proforma, which will be entered and analyzed using spss version 26.0. for quantitative variables such as: age, operation time, hospital stay, stone number ,mean and standard deviation will be calculated and for qualitative variables such as: gender, and laterality, stone location, ureter condition, prevalence of pyuria, stone clearance, presence of retropulsion, ureter injury, frequency and percentages will be calculated. data will be presented in tables and graphs for both quantitative and qualitative variables. chi-square test will be used to estimate the association between study variables. p-value \<0.05 will be considered significant. it is anticipated that the results of this study will be helpful for health care planners and surgeons to provide better treatment option to the patients with ureteral stone.


Eligibility criteria:
inclusion criteria: 1. stone size 1cm to 1.5cm at proximal ureter. 2. patients aged between 15 to 70 years. 3. both genders. exclusion criteria: 1. patients with active urinary tract infection 2. pregnancy 3. immunocompromised patients

Keywords: laser urs dj stent lithotripsy eswl ursl
diagnostic role of renal biopsy in patients with fabry disease

Conditions: Fabry Disease

Summary: this is a retrospective, single-centre, non-pharmacological observational study carried out for scientific and health protection purposes. it provides for the systematic collection of information from the medical records of patients with a genetic diagnosis of fabry disease referred to the single centre of renal genetic diseases of the irccs azienda ospedaliero-universitaria di bologna. these patients were considered eligible for the biopsy procedure if: * presence of a clinical picture compatible with a classical phenotype * presence of laboratory (microalbuminuria, proteinuria, gfr reduction by various methods) or instrumental (renal ecostructural features) pathological alterations suggestive of fabry disease * presence of vus * presence of an abnormal course of nephropathy or doubtful overlapping pathology. patients with esrd were excluded.

the main objective of the study is to evaluate the diagnostic capacity, currently undocumented in the literature, of renal biopsy in patients with anderson-fabry disease, afferent to the sant'orsola-malpighi general hospital's single centre for renal genetic diseases. as secondary objectives we intend to assess whether the renal damage associated with fabry disease, evidenced by histological features obtained by biopsy, manifests differently in subgroups of patients defined by: * gender * ckd stage * genetic mutations individual pathological lesions are assessed using the scoring system devised by the international study group of fabry nephropathy (isgfn). all patients with a definite diagnosis of fabry's disease who have been admitted to the irccs azienda ospedaliero-universitaria di bologna's single centre for renal genetic diseases from 01/01/2012 to 31/12/2020 are eligible. based on the number of patients afferent to the genetic kidney disease outpatient clinic, approximately 80 patients will be enrolled. the comparison will be performed on the basis of variables that are associated with fabry disease in the literature, such as enzyme activity assessment, lyso-gb3 assay, renal function parameters, enzyme therapy, genetic mutations and cardiac markers.

Eligibility criteria:
inclusion criteria: * subjects over 18 years of age with a diagnosis of fabry disease defined based on the 2017 guidelines. * obtaining written informed consent exclusion criteria: * none
evaluation of pku sphere liquid

Conditions: Phenylketonurias

Summary: pku sphere liquid is a prospective, open-label, acceptability study to evaluate pku sphere liquid in up to 15 participants aged 3 and above for the dietary management of pku over 31 days.

pku sphere liquid is a newly-developed food for special medical purposes (fsmp) designed for the dietary management of patients with phenylketonuria (pku). pku sphere liquid is a vanilla flavoured, ready-to-drink, low phenylalanine protein substitute containing a blend of casein glycomacropeptide (gmp) isolate, essential and non-essential amino acids, carbohydrate, fat, vitamins, minerals, and docosachexaenoic acid (dha). this is a feasibility study designed to evaluate the acceptability, tolerance and adherence of children and adults consuming pku sphere liquid. participants will be given a four-week supply of pku sphere liquid and they will be asked to complete a daily diary and short questionnaire for four weeks to record information on: adherence, gastrointestinal tolerance, palatability and how the product is used. each participant will be on the trial for 31 days. this includes a 3-day baseline period and 28 days taking the study product. if deemed appropriate in each individual circumstance, the sponsor of the trial, vitaflo international ltd, will continue to supply the product free of charge at the end of the trial until available on prescription.

Eligibility criteria:
inclusion criteria: * diagnosis of pku requiring a low protein diet and protein substitute. * aged three (3) years and over * already taking a minimum of one gmp based protein substitute per day or have previously taken one * able to comply with the study protocol and take the study product, according to the opinion of the pi. * willingly given, written, informed consent from patient or parent/guardian. * willingly given, written assent (if appropriate). exclusion criteria: * inability to comply with the study protocol, in the opinion of the investigator. * any co-morbidity, which, in the opinion of the investigator, would preclude participation in the study. * diagnosis of persistent hyperphenylalaninaemia, or mild pku not requiring dietary intervention with a low protein diet and protein supplement. * unwilling/unable to take a gmp based protein substitute. * women who are pregnant / breastfeeding at the start of the study or planning to become pregnant during the study period. n.b.: women who become pregnant unexpectedly during this study will be immediately withdrawn from the study.

Keywords: pku sphere liquid
a feasibility trial of avastin (bevacizumab) in combination with concomitant chemoradiation (cisplatin and vinorelbine) in patients with locally advanced non-squamous non-small cell lung cancer.

Conditions: Non-Squamous Non-Small Cell Lung Cancer

Summary: this single arm study will assess the feasibility of use, safety and tolerability of avastin(bevacizumab) in combination with chemoradiation therapy in patients with locally advanced unresectable non-squamous non-small cell lung cancer.an initial cohort of patients will receive avastin 7.5mg/kg iv every 3 weeks, in combination with concurrent thoracic radiation for 6.6 weeks and chemotherapy (cisplatin 75 mg/m2 iv and vinorelbine 15mg/m2 iv administered according to a standard treatment protocol). if no dose-limiting toxicities are observed, a second cohort of patients will receive avastin at a dose of 15mg/kg iv every 3 weeks, in combination with a similar treatment regimen to that of the first cohort. after 5 cycles of combination treatment, avastin monotherapy will be administered for a further 4 cycles. the anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * patients \>=18 years with locoregional advanced unresectable non-squamous nsclc; * ecog performance status of 0 or 1; * no prior thoracic head and neck irradiation or surgical resection for current lung cancer. exclusion criteria: * mixed, non-small cell and small cell tumors; * mixed adeno-squamous carcinomas with a predominant squamous component; * evidence of tumor invasion or encasement of major vessels; * history of grade \>=2 hemoptysis; * presence of cavitations in lung lesions at baseline.
clinical factors associated floppy iris

Conditions: Pupil Constriction; Iris Floppiness; Iris Prolapsus From the Wound

Summary: this study is planned to investigate the incidence of intraoperative floppy iris and its relationship with pseudoexfoliation, diabetes, hypertension as well as systemic alpha-1 adrenergic blocker use.

our aim is to investigate the incidence of intraoperative floppy iris syndrome (ifis) signs and evaluate the relationship of ifis signs as well as complete ifis with pseudoexfoliation, diabetes, hypertension, and alpha-1 adrenergic blocker (a1ab) use. five-hundred patients will be included in this prospective study. preoperatively, pupil diameter before and after dilation, presence of pseudoexfoliation, history of diabetes, hypertension, and use of any a1ab will be recorded. intraoperative adverse events such as pupillary constriction, iris billowing, and iris prolapse from the wound will be noted. multinomial regression analysis will be used to evaluate the relationship of ifis signs with pseudoexfoliation, diabetes, hypertension, and a1ab usage. according to the results we will determine the incidence of ifis in our patient population and evaluate its relationship with alpha-1 adrenergic blocker use. we will also investigate the relationship of floppy iris problems with pseudoexfoliation, diabetes, high blood pressure.

Eligibility criteria:
inclusion criteria: * subjects with the diagnosis of cataract who were decided to have phacoemulsification exclusion criteria: * previous history of trauma or surgery of the eye, congenital ocular disease including cataract, infection, inflammation, angle closure glaucoma, or medication (topical) that might affect the size and shape of the pupil only the first operated eye of each patient was included.

Keywords: alpha-adrenergic blockers cataract surgery pseudoexfoliation syndrome diabetes mellitus hypertension pupil