Kornimate/medical-research-clean huggingface dataset:
online cognitive behavioral therapy for bulimia nervosa

Conditions: Bulimia Nervosa

Summary: cognitive behavioral therapy for bulimia nervosa (cbt4bn) is a research program funded by the national institute of mental health and conducted by the unc eating disorders program and the university of pittsburgh medical center. cognitive behavioral therapy (cbt) is an evidence-based treatment and the gold-standard for treating bulimia nervosa. the current study aims to compare two forms of cbt: face-to-face group therapy and online group therapy via cbt4bn.org.

all treatment is conducted by trained professionals from either the unc eating disorders program (in chapel hill) or western psychiatric institute (in pittsburgh) who are experienced in the treatment of eating disorders. participants will participate in 16 1.5 hour long group sessions of group cbt over 20 weeks. groups will include 5-8 participants, one or two co-therapists, and two sessions by a registered dietitian. participants will be expected to complete self-monitoring forms which assess their mood and behavior. groups will either take place face-to-face or online in a therapist-moderated chat group.

Eligibility criteria:
inclusion criteria: * dsm-iv criteria for bn * internet access at home * either off psychotropic medication for at least one month or on a stable dose of psychotropic medication exclusion criteria: * any major medical condition that would interfere with treatment or require alternative treatment * alcohol or drug dependence in the last three months * current significant suicidal ideation * developmental disability that would impair the ability to use the internet program effectively * psychosis, including schizophrenia, or bipolar i disorder
fallstalk falls prevention program for caregivers and persons with memory loss or dementia

Conditions: Falls (Accidents) in Old Age

Summary: this randomized-control trial involves dyads consisting of a family caregiver (cg) and a person with memory loss or dementia (pwd). the fallstalk caregiver resource system (ft-c) intervention is administered by the cg, whose role is to modify their interactions with the pwd. ft-c will create a 3-way partnership between an interventionist and the dyad, capitalizing on cg-pwd interactions. the pwd will be observed by the cg and both will be evaluated by the study team. brief daily ft-c intervention by the cg will stimulate the pwd's awareness and individualized weekly cg- check-ins with the interventionist will increase the cg's skills. our hypothesis is that ft-c will increase pwd's awareness of personal fall threats and encourage new falls prevention behaviors, resulting in reduced fall rates.

this is a single-site preliminary trial enrolling dyads in western washington state only.

Eligibility criteria:
caregiver (cg) inclusion criteria: * residence in western washington state * minimum age= 18 * family cg * primary cg * some daily personal contact with person with dementia (pwd) for 1 month * basic computer skills and telephone access * able to commit to 6 month study. persons with dementia (pwd) inclusion criteria: * living at home with residence in western washington state * minimum age= 55 * at least one fall in last 6 months or regular loss of balance * can ambulate at least 6 feet * ability to communicate thoughts * willingness to participate. cg exclusion criteria: * professional cg (unless primary cg for family member) * distance cg unable to be physically present with pwd daily for 1 month * terminal illness with less than 6 months to live * cg has significant memory loss. pwd exclusion criteria: * residence outside of western washington state * living in residential care setting * non-communicative * terminal illness with less than 6 months to live * wheel chair or bed bound.

Keywords: prevention
the effect of different education methods before invasive urodynamics

Conditions: Urologic Diseases; Urodynamics

Summary: aim: this study was carried out to compare the effects of different education methods utilized before a urodynamic testing procedure on patients' pain, anxiety, readiness for the procedure, and satisfaction. background: urodynamic testing is an invasive procedure that causes pain and anxiety. patient education is an evidence-based nursing intervention that relieves pain and anxiety and increases patient satisfaction. design: the study is a single-center, randomized controlled clinical trial. method: participants (n=80) were randomly assigned to four groups. while patients in the control group were provided with routine clinical information, patients in the intervention group were given education with brochures, videos, and brochure-supported videos. the research data were collected by using a data collection form with items about participants' descriptive characteristics, the state anxiety inventory, and the visual analog scale.


Eligibility criteria:
inclusion criteria: * older than 18 years of age, * had urodynamics for the first time, * had no communication problems, * volunteered to participate in the study exclusion criteria: * had major hearing, vision, and speech impairments, * used antidepressants, or anxiolytic drugs, * had an indwelling urinary catheter, * used any analgesic in the 24 hours before coming to the urodynamic laboratory

Keywords: pain anxiety satisfaction readiness patient education nursing urodynamics
bifurcation stenting using 2 link stent nobori versus 3 link stent xience

Conditions: Coronary Stenosis

Summary: the primary objective of this study is to make a comparison of safety and efficacy of dess with different link number (2-link nobori and 3-link xience) in patients with de novo true bifurcation lesions. the minimum lumen diameter of the side branch ostium in bifurcation at 8 months and the mace rate until one year after pci will be assessed in both groups.


Eligibility criteria:
inclusion criteria: 1. patient eligible for percutaneous coronary intervention 2. patient or substitute decision-maker willing to provide written informed consent, which is approved by the institutional review board or its equivalence 3. de novo stenosis at coronary bifurcation with up to two vessels (visually estimated diameter stenosis ≥50%) 4. second vessel at coronary bifurcation treatable with trial device during the procedure 5. true coronary bifurcation, ≥50% diameter stenosis in both the main and side branches, belonging to the medina classes 1.1.1, 1.0.1, and 0.1.1, 6. visually estimated target lesion reference vessel diameter, 2.5-5.0 mm in the main branch, ≥2.25 mm in the side branch 7. target lesion treatable with one or two stents in both the main and side branches 8. consensus of pci after discussion between cardiologists and cardiac surgeons for the lesion in the left main coronary artery 9. thrombolysis in myocardial infarction grade ≥1 flow in both the main and side branches exclusion criteria: a. general restrictions 1. unable to be followed by the implementing medial institution 2. life expectancy \<1 year 3. acute myocardial infarction (\<1 week) 4. left ventricular ejection fraction \<30% 5. scheduled for elective treatment requiring antiplatelet drug withdrawal 6. deemed as unsuitable by the investigator or subinvestigator 7. serum creatinine level ≥2.0 mg/dl b. vascular morphological restrictions 1. lesion proximal to coronary artery bypass graft anastomotic site (visual estimation ≤5.0 mm) or including a part of coronary artery bypass grafting 2. in-stent restenosis 3. severe calcification

Keywords: true bifurcation stenosis
influence of yogic breathwork on sleep

Conditions: Sleep

Summary: the purpose of this research study is to determine the influence of a regular yogic breathing practice on sleep, and to find out primarily if a regular practice of 8-week yogic breathing would enhance sleep quality as well as if it would improve participant's quality of life, and reduce existing stress. study participants will be randomized into two arms for different breathing practices.

the purpose of this study is to determine the effects of two remotely-delivered 8-week breathing interventions on long term sleep patterns. the study protocol consists of healthy participants (randomized in two breathing groups) undergoing a remotely delivered 8-week intervention and a 12-week sleep tracking period (including 2 week before the intervention, 8 week during the intervention, and 2 week after the intervention). several sleep metrics will be extracted to characterize long-term sleep patterns and degree of sleep improvement. participants will also be asked to complete pre- and post-intervention questionnaires. the two remotely delivered interventions will be guided by two separate certified experienced yoga teachers. both interventions will include 60-minute weekly group virtual sessions (1day/week) with a 20-minute daily home sessions (in between weekly sessions; 6 days/week) using home-aid practice materials.

Eligibility criteria:
inclusion criteria: * 18-65 years of age * able to provide their consent to be in the study * available and able to participate in study activities * who can lie in supine * who have little to no prior/current regular practice of breath awareness and training * compatible devices for physiological data trackers exclusion criteria: * inability to provide informed consent * history of neurological disorders, craniospinal disorders, spinal injury * diagnosed/treated sleep disorders such as sleep apnea with the use of cpap * allergic or respiratory disorders * major or uncontrolled psychiatric illness or trauma or major depression * lung and heart problems * any condition requiring the use of medication that acts on the brain like stimulants/sedatives * current substance abuse issues * pregnancy or nursing

Keywords: sleep yogic breathwork digital health technology yoga yogic breathing slow breathing sleep tracking remote research studies wearable devices
relapse prevention in alcohol dependency by transcranial direct current stimulation supported cue exposure therapy

Conditions: Alcohol Dependency

Summary: relapse is a major risk in substance abuse disorders, which is closely related to craving for a substance, describing a strong urge for consumption. cue-exposure therapy is an intervention aiming at the reduction of perceived craving by repeated confrontation. it is based on the assumption that craving drops after repeated exposure without the reinforcing experience elicited by consumption. in the present study, patients with alcohol dependency take part in nine cue-exposure training sessions. each session consists of mood induction reflecting a high risk situation with subsequent in vivo confrontation with one's preferred alcoholic beverage followed by the training of coping strategies. during the cue-exposure, patients focus on perceiving automatic responses to alcohol-related cues. we hypothesize that especially patients exhibiting initially high reactions to such cues should profit from this intervention the most. the reactions are measured on a subjective (craving) and physiological level (hemodynamics of the prefrontal cortex, heart rate variability, electrodermal activity). furthermore, we want to strengthen the expected training effects during the cue-exposure by an activating transcranial direct current stimulation of the dorsolateral prefrontal cortex, which has been shown to be hypoactive in substance abuse disorders. we investigate how the cue-exposure training affects the processing of alcoholic cues (cue-reactivity) and its relation to clinical symptoms of alcohol dependency.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of an alcohol dependence (f10.2) * abstinence motivation exclusion criteria: * epileptic seizures * acute psychotic episode * another substance use disorder besides nicotine dependency (f17.2) * acute withdrawal symptoms
safety and efficacy of multiple doses of intranasal ketorolac in postoperative pain following major abdominal surgery

Conditions: Postoperative Pain

Summary: ketorolac has been marketed for several years in other forms (tablet and injectable) for the short-term relief of pain. this study will test whether a new dosage form (nasal spray) containing ketorolac is effective at relieving the pain of major abdominal surgery, and will also assess product safety. previous studies with the nasal spray have suggested that it is similar to the previously approved injectable form in effectiveness for pain relief and in its safety profile. patients will be randomized in a 2:1 ratio to receive intranasal ketorolac or placebo when the pain reaches a moderate level (40 on a scale of 100) following surgery. after the first dose, subjects will receive study drug every 6 hours for 48 hours, and then as needed (up to 4 times a day) for a total of 5 days. if pain is not adequately relieved by the study drug, subjects will be given morphine sulfate or other standard analgesics. follow-up safety evaluations will occur about 1 and 2 weeks after the start of dosing. subjects will be asked to answer questions about their pain relief and any possible side effects of the drug during the study, and will be given physical examinations, including nasal evaluations, before and during the clinical trial. a small amount of blood will be drawn for routine clinical laboratory testing.


Eligibility criteria:
inclusion criteria: * men or women age 18 through 64 years * major abdominal surgery * body weight ≥ 100 and ≤ 300 pounds * negative serum pregnancy test * pain intensity score at least 40 (moderate pain) on 100 mm visual analog scale * minimum 48 hour hospital stay and 5 day maximum stay * able to provide written informed consent * willing and able to comply with all testing requirements of the protocol exclusion criteria: * allergy or sensitivity to ketorolac or ethylene diamine tetraacetic acid (edta) * allergy or significant reaction to opioids * allergic reaction to aspirin or other nonsteroidal anti-inflammatory drug (nsaids) * current upper respiratory tract infection or other respiratory tract condition that could interfere with absorption of the nasal spray or adverse event assessment * use of any intranasal product in past 24 hours * clinically significant abnormality on screening lab tests * history of cocaine use * active peptic ulcer disease or significant history of peptic ulcer disease or gastrointestinal bleeding * advanced renal impairment or risk for renal failure * history of other medical problems that could interfere with the study participation * pregnancy or breastfeeding * participation in another investigational study within past 30 days
the effect of nice support program on frailty and quality of life in patients with heart failure

Conditions: Frailty; Quality of Life

Summary: this rct study aims to examine effects of a nice support program in heart failure patients. the following hypotheses were tested: patients who received the nice program will report significant improvement in frailty , social support, anxiety, and depression, quality of life, and nutritional assessment at baseline,4 weeks, 12 weeks and 24 weeks.

this study aims to develop nice support program, and examine the effects of an nice program in heart failure patients. an experimental design is used. subjects are selected using a purposeful sampling and are randomly assigned to the intervention or control group by using block size randomization method. patients in the intervention group will receive a 12 week nice support program including: individual consultation, nutritional consultation, teaching exercise which contain walking and resistance exercise by using elastic bands and elastic balls. data are collected by physical indicators and a structural questionnaire to measure frailty, quality of life, social support, anxiety and depression, symptom distress at baseline, 4 weeks, 12 weeks and 24 weeks . data analysis includes descriptive statistics, pearson correlation coefficient, independent t test, chi square, one way anova and generalized estimating equation.

Eligibility criteria:
inclusion criteria: 1. aged above 20 and stable condition and had received physical activity. 2. clear consciousness, can communicate with chinese and taiwanese. 3. consent to join in this study. 4. have a smartphone and be able to join social media(line: heart together-go go go ) exclusion criteria: 1. bed-ridden or unable to perform activities of daily living independently. 2. unstable illness condition. 3. emergency condition. 4. contraindications of performing exercise such as uncontrolled hypertension, uncontrolled arrhythmia. 5. patients with increased nerve, muscle, bone or rheumatoid diseases due to exercise

Keywords: frailty quality of life heart failure exercise program nutrition
effects of etomidate on postoperative circadian rhythm changes of salivary cortisol in children

Conditions: Congenital Hydronephrosis; Congenital Choledochal Cyst; Fracture

Summary: etomidate is an unique drug used for induction of general anesthesia and sedation. adrenal cortical inhibition by etomidate has received much attention. however wether the circadian rhythm and pulse secretion pattern of cortisol in children are the same as that in adults is not known. moreover, the effect of etomidate on circadian rhythm changes and clinical outcomes has never been carefully studied in children undergoing surgery. our hypothesis is that etomidate can relieve the changes of circadian rhythm of salivary cortisol in children for 24-48 hours，and this does not make clinical outcomes worse postoperatively.

* sample size assessment: using formula to calculate the total number is 30. * statistical analysis: anova * reporting for adverse events: during the period of study, if there is any severe adverse event happening, such as severe infection, severe low cortisol concentration threatening the patient's life we will stop the trial.

Eligibility criteria:
inclusion criteria: * 3-12 years old who are plan to undergo surgery exclusion criteria: * endocrine disease, blood infusion, having fever, ulcer or bleeding in the oral cavity

Keywords: salivary cortisol circadian rhythm children etomidate
investigation of the efficacy of different treatment approaches on sexual health in healthy women

Conditions: Pelvic Floor Disorders

Summary: sexual health is one of the important factors affecting the quality of life and general health of individuals. sexual life, with its personal and social aspects, is an inseparable part of the human being in general. it is one of the most important factors in human life and happiness, especially in family life. sexuality positively integrates and enriches the somatic, emotional, intellectual and social aspects of individuals, and develops a personality, communication and love. the concepts of sexuality and sexual health have long been considered taboo. this situation negatively affects rehabilitation strategies. studies are known to have sexual problems in women more than men.

there are many factors that affect sexual function. in the etiology of female sexual dysfunction; neurogenic, vascular, hormonal, musculogenic and psychogenic factors are included. if female sexual dysfunction causes distress, it negatively affects women's quality of life. the repetition of problems related to sexual response, pain, orgasm and desire, which cause interpersonal problems and discomfort, creates a complex problem. pelvic floor muscles are known to play an important role in sexual function as they are responsible for involuntary rhythmic contractions during orgasm and vaginal sensation during intercourse. studies have reported that pelvic floor disorders affect one-third of adult women and significantly reduce their quality of life. different treatment methods applied to the pelvic floor muscles increase the level of muscle strength and muscle activation. increasing pelvic floor muscle strength affects individuals' sexual life positively and reduces the problems encountered. conservative treatment modalities include exercises for the pelvic floor muscles, functional electrical stimulation, and surface electromyography. exercise practices are one of the important approaches that strengthen the pelvic floor muscles. these exercise approaches can be given in the form of home exercise applications, as well as device-assisted applications.

Eligibility criteria:
inclusion criteria: * healthy adults aged 18 and over * having an active sex life exclusion criteria: * latex allergy * other allergies in the pelvic area * vaginal or urinary tract infection * gynecological cancer

Keywords: woman's health exercise
role of systemic inflammation in increase of cardio-vascular risk in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose is to study the correlation between systemic inflammation (serum levels of crp, il-1beta, il-6 and tnf-alpha) or hyperhomocysteinemia and the increase of mortality, in a representative cohort of patients with chronic obstructive pulmonary disease (copd). secondary purposes are: 1. to confirm the increase of cardiovascular mortality and the importance of cardiovascular morbidity in patients with copd, 2. to establish the role of various genetic polymorphisms in the correlation between systemic inflammation and cardiovascular disorders observed in copd, 3. to search for acceleration of aging of cardiovascular system evaluated with carotid intima-media thickness when systemic inflammation markers are increased, 4. to study the correlation between copd risk factors (tobacco and other food factors), change of respiratory functional data and cardiovascular morbi-mortality. in this study cardiovascular morbi-mortality is defined by following disorders: ischemic cardiopathy, left-sided heart failure, cardiac arrhythmia and cerebrovascular accident. diagnosis is confirmed with standard techniques and independently of this study. results of clinical examination, ecg, echocardiography and /or brain scanner will be collected.


Eligibility criteria:
inclusion criteria: * actual or past active smoking of at least 20 packets/year * fev1/fvc \< 70% exclusion criteria: * co-morbidity except essential arterial hypertension controlled by treatment, stable coronary disease, type 2 diabetes and/or degenerative arthropathy (non-inflammatory rheumatic disorder) * acute disorder during 8 weeks before inclusion, especially copd worsening * long-term corticosteroid or non-steroid anti-inflammatory treatment

Keywords: systemic inflammation
salivary catecholamines in aphthous stomatitis (canker sores)

Conditions: Canker Sore

Summary: the purpose of this study is to examine how compounds produced in patients with canker sores affect wound healing.

the purpose of this study is to determine if salivary catecholamines are elevated in patients with the disease aphthous stomatitis. the results of this study will be combined with those performed in collaboration with a co-investigator to understand the effects of catecholamines on mucosal wound healing and oral epithelial cell migration.

Eligibility criteria:
inclusion criteria: * age 18 or older, both genders * history of recurrent aphthous ulcers with 4 or more episodes per year exclusion criteria: * history of salivary gland disease including sjogren's disease, parotitis, and sialolithiasis * history of benign or malignant salivary gland tumor * history of celiac disease, ulcerative colitis or crohn's disease * patients on medications that affect salivary flow such as anti-depressants and anti-cholinergic medications