Kornimate/medical-research-clean huggingface dataset:
the effect of calcium on fecal fat and energy excretion

Conditions: Obesity

Summary: the overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

several reports have found inverse associations between calcium intake and body weight. few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. the mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles. the aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.

Eligibility criteria:
inclusion criteria: * healthy meals * bmi 24-31 kg/m2 * age between 18-50 years exclusion criteria: * donation of blood 6 months before and under the study * milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease * use of dietary supplements 3 months before and under the study * smoking * elite athletes * use of medication

Keywords: dairy products, calcium, fat excretion, energy excretion
nurse-initiated conversations for early integration of palliative care in pediatric oncology

Conditions: Solid Tumor; Hematological Malignancies

Summary: this study aims to develop and implement a pediatric palliative care (ppc) program. it is an open-label, randomized trial (2:1 randomization) in pediatric oncology department of children's hospital of fudan university. the intervention group will receive nurse-initiated conversations for early integration of palliative care in pediatric oncology (nice). the control group will receive routine ppc (will be scheduled to meet with the ppc team only when participants themselves, their families, or the attending oncologist requested an appointment). the intervention will take 6 months.

early integration of ppc, endorsed by a number of international societies, is well supported by evidence on providing multi-layer relief in children and their families over the course of any life-threatening illness. this study will leverage oncology nurses' role, culturally adapt the well-recognized st. jude children's individualized care planning and coordination (icpc) model to develop and evaluate a nurse-initiated conversation program to facilitate early integration of palliative care in pediatric oncology care.

Eligibility criteria:
inclusion criteria: * children within eight weeks of initial oncologic diagnosis or within eight weeks of relapse/recurrent disease diagnosis * children speaking chinese * children's family caregivers accompanying the child in the hospital (only one family member is eligible to take this role under current hospital policy) * children's family caregivers speaking chinese * health care providers who are taking care of the eligible children, including but not limited to physicians, nurses, and social workers exclusion criteria: - children who, in the opinion of their physician, are not capable mentally or verbally of participating in the survey or interview
safety and efficacy of pimecrolimus cream 1% in atopic disease modification

Conditions: Atopic Dermatitis

Summary: this study consists of a 3-year double-blind phase during which patients will receive atopic dermatitis (ad) treatment either with pimecrolimus cream 1% long-term management (ltm) or with a conventional corticosteroid-based treatment (1:1 ratio), followed by a 2 to 3-year open-label (ol) phase (all patients receiving pimecrolimus cream 1% ltm). at the end of the double-blind phase, the two treatment groups will be compared with respect to their efficacy in controlling ad; at the end of the ol phase, the incidence of asthma at the age of 6 years will be compared.


Eligibility criteria:
inclusion criteria: * diagnosis of atopic dermatitis * family history of atopy * 3 to 18 months of age at baseline * at least mild atopic dermatitis at baseline (investigator global assessment \[iga\] greater or equal to 2) * clinical evidence of atopic dermatitis for no longer than 3 months exclusion criteria: * diagnosis of or substantial clinical evidence for food or other allergies at baseline other protocol related criteria may apply

Keywords: atopic, dermatitis, asthma, children, modification atopic dermatitis/atopy
pc miroir : effects of mirror therapy in children with hemiplegic cerebral palsy

Conditions: Hemiplegic Cerebral Palsy

Summary: this is a randomized and comparative prospective test, monocentric and controlled (mirror therapy versus bimanual rehabilitation exercises), in single-blind (investigator and occupational therapist " 1 " do not know the type of rehabilitation performed).


Eligibility criteria:
inclusion criteria: * unilateral spastic cerebral palsy as defined by scpe (surveillance of cerebral palsy in europe) * aged 7 to 17 years * macs (manual ability classification system) 1 to 3 * extension of the wrist more than 10° * free, informed and written consent of the parents * free, informed and written consent of the child * affiliated, via his/her parents, to the social security regime exclusion criteria: * other neuromuscular disorders known * cognitive impairment hampering the understanding of instructions * upper-limb pain (eva score \>3) * restriction of passive range of motion * visual impairment not allowing the visualization of the upper limb in the mirror * upper-limb botulinum toxin injection in upper limb 6 months prior to inclusion

Keywords: unilateral cerebral palsy children upper-limb mirror therapy bimanual coordination kinematics analysis
orbitofrontal cortex (ofc) influence on addictive medication overuse headache (moh) deriving from migraine

Conditions: Medication Overuse Headache

Summary: medication overuse headache (moh) is an illness affecting about 1,5 % of the general population. it is characterized by chronic headache occurring for at least 15 days a month, by a use of antimigraine drugs during at least 3 months for more than 10 days a month (for ergots, triptans, opiate derivates and combined analgesics) or for more than 15 days a month (for simple analgesics). the chronic headache must have occurred during the period of antimigraine drug abuse and the headache must have returned to its episodical pattern after withdrawal of antimigraine drugs. but, about 50% of the moh patients will relapse during the first year following the antimigraine drugs withdrawal. the pathophysiology of moh is still largely unknown, and the role of antimigraine drug abuse in the transformation from migraine through moh is not fully understood.

we recently explored cerebral metabolism in these moh patients using (18f)fdg-pet (fluoro dexoxy glucose positon emission tomography) comparing them with controls. results showed a hypometabolism in the ofc, which persist immediately after the antimigraine drugs withdrawal. a similar pattern is observed in varied substance related disorders and should be a marker of addictive behaviour. it can be linked with difficulties in the decision-making process, which can be explored by the iowa gambling task (igt) test. several questions are still unanswered. what will this abnormality become in the long term ? is it predictive of susceptibility for relapse? can it be linked to a specific psychological profile (addictive behaviour)?

Eligibility criteria:
inclusion criteria for patients : * older than eighteen years * suffering from moh (ichd-ii criteria) * french speaking * who wish to go on a withdrawal procedure exclusion criteria : * pregnant women or women of child bearing age who are not using contraception * post traumatic headaches * illnesses interfering with the central nervous system functionning * psychotic disorder or current major depressive episode * contraindication for pet or mri (magnetic resonnance imaging) * contraindication for all prophylactic treatment for migraine

Keywords: orbitofrontal cortex medication overuse headache chronic headache withdrawal
short vs. long antibiotic treatment of implant-free osteoarticular infections

Conditions: Implant Infection

Summary: the investigators tested the working hypothesis if 4 weeks of systemic antibiotic treatment in implant-related orthopaedic infections is non-inferior to 6 weeks after complete removal of the infected implant. randomization 1:1. the study is completed. it halted prematurely and will not resume; participants are no longer being examined or receiving intervention.

former description of the study (now completed) osteoarticular infections related to orthopaedic implants are associated with substantial morbidity, prolongation of hospital stay, and additional costs. due to the increasing number of patients with orthopaedic implants in switzerland, similar to the rest of europe and elsewhere, the number of infections is expected to increase. while the surgical treatment of these infections has been well studied, the ideal duration of antibiotic therapy after removal (explantation) of the infected implant remains unknown. for almost 40 years, the recommended total duration of post-explantation antibiotic therapy has been 6 weeks. this recommendation is based on expert's personal experience rather than on prospective randomized studies. shorter treatment would decrease antibiotic-related adverse events and costs hospital stay for patients awaiting an eventual reinsertion of a new implant. if physicians and surgeon prescribe antibiotics for 6 weeks, this duration should be at least supported by evidence.

Eligibility criteria:
inclusion criteria: * adult patients (≥17 years old) * total removal of the implant exclusion criteria: * primary native joint septic arthritis; * co-trimoxazole prophylaxis because of immunosuppression; * left-side endocarditis; * persistent implant material in the infected area. * infections with tuberculosis; mycobacteria; fungi; brucellosis; borreliosis; nocardiosis; and mycoplasmal osteosynthesis infections

Keywords: implant-related infections orthopaedics implant removal antibiotic duration outcome
optical coherence tomography imaging of post coil aneurysm healing.

Conditions: Cerebral Aneurysm

Summary: the purpose of this study is to identify the healing of aneurysms in three month use optical coherence tomography image to measure outcomes in post coiled aneurysms. endovascular therapeutic coiling is a widely used procedure in the management of aneurysms, which is an angiogram .

subarachnoid hemorrhage secondary to ruptured cerebral aneurysms, unruptured aneurysms that are being treated using endovascular coiling. the researcher can use optical coherence tomography image at the rime of initial angiography with unruptured aneurysms, and at the three month follow up catheter angiogram. optical coherence tomography image can follow the therapeutic coiling of the aneurysm, the 6f endocatheter and the microcatheter used for the coiling procedure place in the internal carotid artery and parent artery lumen follow with optical coherence tomography fiber insert through the lumen of the tube on which the image can obtain.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years of age * subject diagnosis of aneurysm and undergoing endovascular coiling exclusion criteria: * pregnant women * age ≤ 18 years of age * patient presenting emergently with acutely ruptured aneurysms
a study to evaluate efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (rrmm)

Conditions: Multiple Myeloma

Summary: the purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (rrmm).


Eligibility criteria:
inclusion criteria * participant is willing and able to adhere to the study visit schedule and other protocol requirements including bone marrow aspirations and/or biopsies and hospitalization during the first cycle. * documented diagnosis of multiple myeloma (mm), and must:. i) received at least 1 but not more than 3 prior lines of anti-myeloma therapy. ii) received prior treatment with lenalidomide and an anti-cd38 monoclonal antibody (for at least 2 consecutive cycles). iii) achieved minimal response (mr) or better to at least 1 prior anti-myeloma therapy. iv) documented pd during or after their last anti-myeloma therapy or failure to achieve response. * must have measurable disease (as determined by central laboratory). * eastern cooperative oncology group (ecog) performance status (ps) of 0, 1, or 2 at the time of the screening. exclusion criteria * active, uncontrolled, or suspected infection. * known current, or history of, central nervous system involvement of multiple myeloma. * history or presence of clinically relevant cns pathology. * received prior bcma-targeted tce or bcma-targeted car-t therapy. * previously received allogeneic stem cell transplantation at any time or received autologous stem cell transplantation within 3 months of initiating study intervention. * other protocol-defined inclusion/exclusion criteria apply.

Keywords: relapsed or refractory multiple myeloma bms-986349 cc-93269 rrmm alnuctamab ca058-1019 alumminate rrmm
kinesiotaping on hand function in computer users

Conditions: Computer-user Training

Summary: this study aims to investigate whether kinesio taping contributes to improved hand function in individuals who frequently use computers. the effectiveness of kinesio taping will be compared to sham taping in order to determine its impact. participants will be randomly assigned to one of two groups: a kinesio taping group or a sham taping group. taping will be applied to the forearm. functional assessments will be conducted at three time points: prior to taping, immediately after taping, and 30 minutes post-taping. the following evaluations will be performed: * two-point discrimination test to assess touch sensitivity * purdue pegboard test to evaluate fine motor skills * grip strength test using a hand dynamometer * visual reaction time test utilizing a light-based device all procedures will be completed in a single study session.


Eligibility criteria:
inclusion criteria: * participants must use a computer ≥ 2 hours per day. * participants must be between the ages of 18 and 50. * if the participants are employed, they must not have changed professions in the last 6 months. * if the participants are students, their student status must have been ongoing for at least 6 months. exclusion criteria: * a diagnosed history of neuropathy or common diseases associated with peripheral neuropathy. * diagnosed musculoskeletal disorders related to the neck and upper extremities. * presence of symptoms suggestive of nerve entrapment. * having a condition that prevents the application of physical tests (e.g., limited range of joint motion, deformities, fractures, arthritis, etc.). * allergic reaction to kinesiology tape.

Keywords: kinesiotaping sensation dexterity reaction time athletic tape
a retrospective review of rib fracture pain management at a london major trauma centre

Conditions: Rib Fractures; Pain, Acute

Summary: thoracic epidural analgesia (tea) is widely considered to be the current gold standard treatment for rib fracture pain and is used in the imperial invasive treatment pathway for rib fractures. however, tea are often contraindicated due to other injuries or the use of anticoagulant medications, which also contraindicates other invasive nerve block techniques e.g. paravertebral catheters. a number of case reports have reported the safe use of alternative techniques such as serratus anterior blocks (sapb) and erector spinae blocks (espb) and the anaesthesia community has taken them up widely based on this relatively limited evidence. in view of this, womack et al recently published a large retrospective review examining the safety and efficacy of ultrasound guided paravertebral catheter analgesia techniques in rib fracture management along with small numbers of espbs. however, this data did not report the analgesic efficacy, patient reported pain relief or respiratory complications.the goal is to advance this body of evidence by reviewing our larger data set concerning the use of tea and alternative regional techniques such as espb and sapb. this comprehensive review will benefit patients by documenting the efficacy and safety of these techniques for clinicians managing rib fracture patients.

primary objective the primary objective is to examine whether novel fascial plane blocks, e.g. sapb and espb, are effective pain relief modalities in patients with rib fractures - the proportion of patients with a reduction in pain. secondary objectives the investigators review the safety profile and complications of tea and alternative analgesic techniques such as espb and sapb used for rib fracture management in our trauma centre. in particular the effects of regional anaesthesia techniques on: 1. opioid use 2. nausea \& vomiting 3. respiratory complications 4. intubation \& non-invasive ventilation (niv) 5. icu admission for respiratory complications the investigators will assess the duration of use and complication profile of regional anaesthetic techniques, including infection, analgesic failure and damage to other structures during insertion e.g. the lung.

Eligibility criteria:
inclusion criteria: * patients aged \> 18 years of age presenting with traumatic rib fractures in a major trauma centre over the past 5 years * meet the criteria for the imperial college healthcare nhs trust 'invasive rib fracture management pathway' exclusion criteria: * under 18 years old * prisoners * pregnant * private patients * meet the criteria for the imperial college healthcare nhs trust 'non-invasive rib fracture management pathway'

Keywords: epidural erector spinae block serratus anterior block
the alberta diet: effectiveness study

Conditions: Type 2 Diabetes

Summary: the study hypothesis is that individuals with type 2 diabetes (t2d), who adhere to the panda intervention, will have improved compliance with the nutritional therapy recommendations of the canadian diabetes association. specific objectives of this proposal: the objectives of the investigators panda (physical activity and nutrition for diabetes in alberta) are to (a) to devise and evaluate the efficacy of a multi-level, practical, nutrition intervention program that promotes the individual factors required for effective self-management practices and that explicitly incorporate strategies to improve food availability, accessibility and acceptability and (b) to use these interventions as a means to examine the relationships between food availability, accessibility, acceptability, adherence to nutrition therapy guidelines, and metabolic indicators of diabetes control in people with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes, and speak/write english. * have attended a diabetes education session delivered by their healthcare provider. exclusion criteria: * participants with type 1 diabetes, and those who are unable to speak english. * people with end-stage renal disease or gastrointestinal diseases that require specialized diets will also be excluded.
neurodynamic sequencing in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome is a compressive neuropathy of median nerve in the fascial tunnel at wrist which causes pain, numbness ,and tingling in the extremities. common treatment options used in the treatment of carpal tunnel syndrome are conservative and surgical treatment option is better, this question is still a topic requiring more and more clinical trials. neuromobilisation described by butler is one of the treatment options which are used in the treatment of carpal tunnel syndrome in conjunction with other conservative measures. this proposed study will find out the effectiveness of neuromobilisation in treatment of carpal tunnel syndrome. as there is very little evidence available which neuromobilisation technique is effective and what are the types of patients which can get benefit from this technique. this study will find out the effect of neuromobilisation in patients suffering from carpal tunnel syndrome of non traumatic origin. this is a randomized clinical trial. target population is patients suffering from carpal tunnel syndrome of non-traumatic origin. data will be collected from district headquarter hospital faisalabad. this study will include 56 participants according to the selection criteria. the participants will be randomly divided into two groups through sealed opaque envelop method. group a will recruit 28 patients which fulfill the inclusion criteria. these patients will be treated by nerve sequencing proximal to distal in 3 sets of 15 repetitions in one session on alternate days for 4 weeks. group b will recruit 28 patients which fulfill the inclusion criteria. these patients will be treated by nerve sequencing distal to proximal in 3 sets of 10 repetitions in one session for 4 weeks. the statistical analysis will be performed through spss software 21.


Eligibility criteria:
inclusion criteria: * patients positive for provocative test ( phalen's test, wrist decompression test and tinnel test). exclusion criteria: * inflammation around the wrist * tumor around the wrist * rheumatoid arthritis * osteoporosis * joint hypermobility