Kornimate/medical-research-clean huggingface dataset:
effectiveness of a telerehabilitation program based on specific neck exercises in patients with forward head posture.

Conditions: Forward Head Posture; Neck Pain

Summary: the aim of this study is to compare the effects of a 12-session telerehabilitation program based on specific neck exercises (sne) with spinertial to a control group on range of motion, cervical proprioception, and posture in subjects with forward head posture, post-intervention, after one month of follow-up, and after two months of follow-up.

epidemiological evidence suggests that a sedentary lifestyle is associated with various musculoskeletal conditions, including neck pain. sedentary behavior during work hours is closely linked to the craniovertebral angle (cva). forward head posture, associated with increased vertebral load, predisposes individuals to early onset of degenerative changes, cervical pain, and disability, as well as decreased endurance and strength of the cervical musculature. patients with cervical pain may exhibit various clinical manifestations, including weakness of the deep cervical musculature, reduced cervical range of motion (rom), and cervical disability. numerous pathologies are described to manifest with localized pain in the cervical region, as well as weakness of the deep cervical musculature and reduced craniovertebral angle (cva). examples include cervicogenic dizziness, cervicogenic headache, tension headache, cervical radiculopathy, cervical instability, or chronic mechanical cervicalgia. the sensorimotor control system is a crucial component of the cervical spine. the deep musculature of the cervical region contains a large number of neuromuscular spindles and mechanoreceptors, providing information about the movement of the head and enhancing dynamic stability during neck movements. the density of neuromuscular spindles in the deep musculature is particularly high, suggesting a significant role in the fine motor control of the cervical spine. impairment of cervical posture, decreased craniovertebral angle (cva), proprioception, and alterations in the sensorimotor control system associated with neck pain contribute to recurrence and chronicity.

Eligibility criteria:
inclusion criteria: * forward head posture (craniovertebral angle less than 50º). * deep flexor strength deficit in craniocervical flexion test. * deep extensor strength deficit in neck extensor muscle endurance. * ≤ 14 score in neck disability index. exclusion criteria: * have received cervical treatment during the last six months. * presence of any red flag, neurological, or cognitive impairment (inability to - - understand the questionnaires or examination). * have received cervical manual therapy treatment during the last six months. * history of cervical trauma or surgery during the last year. * chronic neck pain occurring during the last six months (intensity: visual analogue scale \>3/10, frequency \>2 days/week, duration \>3 hours/day).

Keywords: telerrehabilitation deep cervical muscles neck muscles exercise therapy specific neck exercises
evaluation of a health promotion intervention for persons with mental illness

Conditions: Mental Illness

Summary: this pilot study evaluates an individualized health promotion program for people with mental illness receiving services at a mental health center in keene, nh. the study will test the following hypotheses: hypothesis 1: compared to baseline (pre-study) levels, participants in the in shape program will demonstrate increased physical activity as indicated by self-report and observed measures. hypothesis 2: compared to baseline (pre-study) levels, participants in the in shape program will demonstrate improved fitness and health status as indicated by greater capacity on the 6-minute walk test, one mile walk test, weight and body composition, and flexibility indexes. the following secondary (exploratory) hypotheses will be considered: compared to baseline (pre-study) levels, participants in the in shape program will demonstrate improved subjective health status, quality of life, mood, and self-efficacy. in addition, participants will demonstrate improved cardiovascular fitness as indicated by lower pulse rate and blood pressure.

the in shape program aims to improve the physical fitness and health of persons with mental illness. participants in the program are assigned a health mentor who assesses individual lifestyle habits and health status, identifies goals for lifestyle change, and serves as a motivator and physical trainer. the individualized components of the in shape program are supplemented with group-level positive reinforcement and motivational incentives. this evaluation project systematically evaluates the in shape health promotion intervention.

Eligibility criteria:
inclusion criteria: age 18 or older, and enrolled in the in shape program. mental illness receiving mental health services for 3 months or longer voluntary informed consent or guardian consent signed letter of permission to participate by a physician for individuals with a history of a medical illness or indications of health problems during the evaluation - exclusion criteria: inability to give informed, voluntary consent. primary diagnosis of dementia or a diagnosis of a psychiatric disorder secondary to a medical condition. co-morbid dementia as indicated by an mmse score \<20. exclusion for eligibility as determined by the participant's physician due to medical contraindications (e.g., recent myocardial infarction, stroke (thrombotic or embolic), uncontrolled insulin-dependent diabetes). -

Keywords: health mental illness fitness
vaginal transluminal endoscopic sacrocolpopexy

Conditions: Pelvic Organ Prolapse

Summary: this study aims to evaluate the outcomes of v-notes sacrocolpopexy following vaginal hysterectomy, focusing on perioperative and early postoperative results. the impact of v-notes sacrocolpopexy on patients' quality of life is investigated using validated assessment tools. additionally, operative time, complications, pain scores were assessed.

patients who presented to the obstetrics and gynecology outpatient clinic with complaints related to pelvic organ prolapse, had stage iii or iv prolapse according to pop-q classification, were between 45 and 79 years old, had no contraindications for pneumoperitoneum and trendelenburg position, and were eligible to perform transvaginal notes and gave written informed consent were included in the study. demographic data, age, medical and surgical history, body mass index (bmi), operation time, preoperative and postoperative haemoglobin levels, perioperative complications and length of hospital stay were collected. pelvic organ prolapse quantification (pop-q) scores were evaluated before and 1 month after surgery. quality of life was evaluated before and 1 month after surgery with the turkish-validated pelvic floor impact questionnaire (pfiq-7) and pelvic floor distress inventory (pfdi-20).

Eligibility criteria:
inclusion criteria: * patients who presented to the obstetrics and gynecology outpatient clinic with complaints related to pelvic organ prolapse, had stage iii or iv prolapse according to pop-q classification, were between 45 and 79 years old, had no contraindications for pneumoperitoneum and trendelenburg position, and were eligible to perform transvaginal notes were included in the study. exclusion criteria: * patients with previous pelvic inflammatory disease, deep endometriosis, severe pelvic adhesions, and patients who are at risk of gynecological malignancy and are not suitable for transvaginal surgery were not included in the study.
financial health educational program for increasing financial literacy among underserved communities in western new york

Conditions: Hematopoietic and Lymphoid System Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial evaluates a financial health educational program to educate and increase knowledge for financial health and well-being, and to ensure access to financial knowledge and resources among underserved community members in western new york. financial well-being consists of a person's ability to meet financial obligations, feelings of financial security, ability to make choices related to financial matters. information gathered from this study may help researchers learn how a financial health educational program may increase financial literacy for financial health and well-being among underserved community members in western new york.

primary objectives: i. collaborate with community organizations and leaders to leverage community-based assets to disseminate education about financial literacy. ii. reach medically underserved, high risk community members. iii. enhance financial literacy knowledge among medically underserved, high risk community members. outline: participants attend financial health educational program over 60 minutes. patients also receive educational materials on study. after completion of study intervention, patients are followed up to 30 days.

Eligibility criteria:
inclusion criteria: * being over 18 years old exclusion criteria: * adults unable to consent
trial of the families moving forward (fmf) connect mobile health intervention

Conditions: Fetal Alcohol Spectrum Disorders

Summary: the purpose of this study is to test a new smartphone "app" for parents/caregivers of children with fetal alcohol spectrum disorder (fasd). the app is called families moving forward (fmf) connect. the goal of the app is to provide parents/caregivers with useful information to help manage their children's condition and obtain peer support.


Eligibility criteria:
inclusion criteria: * biological parent or other primary caregiver (e.g., foster or adoptive parent, relative, legal guardian) of a child with fasd or prenatal alcohol exposure (pae) * the parent/caregiver must be at least 18 years old * the child must between the ages of 3 and 12 years old * the child has a diagnosis of fasd or has confirmed pae * the child has lived with the parent/caregiver for at least 4 months and is expected to remain in the home for at least 1 year * the parent/caregiver lives in the united states * the parent/caregiver has a smartphone with ios or android operating system exclusion criteria: * the parent/caregiver is not fluent in english (the fmf connect app and pre-post measures are currently only available in english) * there is another parent/caregiver of the same child or living in the home that is already enrolled in the study (couples are excluded to prevent dependence in the data) * the family has previously received or is currently receiving the therapist-led families moving forward (fmf) program
novel rapid poc diagnostics for covid-19

Conditions: COVID-19 Respiratory Infection

Summary: this is a prospective, multicentre study in which the diagnostic accuracy of multiple covid-19 antigen rapid diagnostic tests will be assessed for covid-19 case detection using prospectively collected nasal swabs and saliva samples from participants suspected to have covid-19 infection (with or without symptoms). the study will last approximately 9 months.

adult individuals with presumptive covid-19, either symptomatic or asymptomatic, will be screened for inclusion at 4 different study sites located in georgia and south africa. enrolled participants will be asked to provide 2 samples: one nasopharyngeal swab that will be utilized for covid-19 diagnosis by standard pcr and one sample (either nasal swab or saliva) to be used for the new antigen rapid diagnostic test under evaluation. at least 2 different antigen tests will be evaluated to determine sensitivity and specificity: novel corona virus (sars-cov-2) ag rapid test kit (jiangsu bioperfectus technologies) and genefinder covid-19 ag rapid test (osang healthcare). the data gathered from this study, could be used as part of the dossier to be submitted to who (world health organization) for review.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * presenting to testing locations linked to the clinical sites * suspected to have covid-19 (as per who or national guidelines). these include the following groups: * individuals with acute onset of any of the following signs or symptoms: fever, cough, general weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnoea, anorexia/nausea/vomiting, diarrhoea, altered mental status (for symptomatic group); * contacts of confirmed cases of covid-19 * individuals residing or working in an area with high risk of transmission of virus * individuals residing or travelling to an area with community transmission * individuals working in any health care setting, including within health facilities or within the community * provided voluntary written consent to participate in this study * provided a specimen suitable for testing exclusion criteria: * individuals unable to cooperate with respiratory sample collection * individuals on oxygen therapy * recent history of excessive nose bleeds * individuals unable to give informed consent * hemodynamic instability as determined by the treating physician
micro-randomized trial to optimize digital oral health behavior change interventions

Conditions: Dental Diseases

Summary: the study will involve a 10-week micro-randomized trial (mrt) to inform the delivery of prompts (via mobile app push notifications) designed to facilitate adherence to an ideal tooth brushing protocol (2x2x4; 2 sessions daily, 2 minutes per session, all 4 quadrants).

the goal of the mrt is to investigate whether delivering (vs. not delivering) a prompt that contains engagement strategies grounded in decision science is beneficial in terms of promoting proximal oral health behavior (ohb) score, which reflects adherence to the 2x2x4 brushing protocol (primary aim) and also mobile health engagement (mhealth; secondary aim). additionally, exploratory aims will concern (a) comparing different types of prompts in terms of proximal ohb score and mhealth engagement, (b) investigating the conditions in which prompts should be delivered to most effectively promote proximal ohb and mhealth engagement; and (c) investigating whether the effect of the engagement prompts (vs. no prompt) on ohb score varies across components of the 2x2x4 brushing regimen (i.e., frequency, duration, or coverage). participants will receive an electronic toothbrush (ebrush) and a mobile app (oralytics) that contains well-established behavior change strategies (e.g., goal setting, monitoring adherence, and feedback). participants will be randomized twice per day - in the morning and the evening - to receive either (a) a push notification containing one of three (randomly selected) engagement strategies or (b) no notification. during the 10 weeks of the study, a bayesian algorithm will iteratively adjust the probability of receiving a prompt or no prompt in any given randomization window, using prior behavioral data collected through the ebrush and mobile app. data patterns suggesting positive effects of the prompts on adherence to brushing protocol, especially duration, will result in higher subsequent probabilities of receiving the prompts, whereas patterns suggesting null or negative effects will result in lower probabilities of receiving the prompts. study results will inform the implementation of a smartphone-delivered behavior change intervention that further adapts the delivery of engagement prompts based on passively collected information from an ebrush and the mobile app.

Eligibility criteria:
inclusion criteria: * adults, age 18 or older. * fluent in english * dentulous/partially edentulous (18+ teeth; at least 2 teeth in each quadrant) * possess a smartphone (ios or android) with a data plan. * willing to allow the passive collection of data on tooth-brushing activities in the home setting for 10 weeks. exclusion criteria: * not fluent in english * edentulous * unable to use a mobile device due to cognitive or physical impairments

Keywords: dental disease health behavior change oral self care behaviors
clinical and basic research of etv plus gm-csf in chronic hepatitis b patients

Conditions: Hepatitis B, Chronic

Summary: previous studies indicated that granulocyte macrophage-colony stimulating factor (gm-csf) could improve survival rate in patients with acute liver failure and obtain higher hbsag seroconversion rate when in combination with peg-interferon for chronic hepatitis b (chb) patients. in this study, investigators will study the clinical effect of entecavir (etv) plus gm-csf in patients with chb compared to etv monotherapy.

antiviral treatment plays critical role in treatment of chronic hbv infection. entecavir, an nucleos(t)ide analogs (na) targeting the viral polymerase, is widely used in china as the first line drug in antiviral treatment for chb patients. the sustained suppression of serum hbv dna to undetectable level has been proven to be associated with the prevention of progression of liver disease and inhibition of the development of hepatocellular carcinoma. according to data published, a rate about 70% hbvdna undetectable could be reached after 1 year therapy. however, the rate of hbsag loss is very low about 0% to 1%. granulocyte-macrophage colony-stimulating factor(gm-csf) is an important cytokine for the generation and propagation of antigen-presenting cells and for priming a cellular immune response. it increases the production of macrophage precursors and, in turn,enhances the t-helper cell (th cell)-mediated cytotoxicity and regulates the tumoricidal cytokines. previous studies indicated that when combined with ifn in patients with chronic hbv infection, it increased the therapeutic efficacy of the latter. recent studies showed that gm-csf benefit patients with acute liver failure. in this study, entecavir (etv) plus gm-csf would be used in patients with chb compared to etv monotherapy. primary objective of the study is to see if there is significant improvement in hbsag loss, rates of hbeag loss and hbv undetectable are also to be observed. function of nk cell from the patients enrolled will be measured during the therapy.

Eligibility criteria:
inclusion criteria: * hbsag positive for more than 6 months * hbeag positive * alt≥80u/l or inflammation score ≥2 of histological examination exclusion criteria: * history of drug allergy to gm-csf * coinfection with hcv, hiv, hav, hev * liver cirrhosis or child score \>7 * diagnosis of hepatocellular carcinoma or afp\>100ng/ml * allergic thrombocytopenic purpura

Keywords: chronic hepatitis b, antiviral treatment
effects of contraceptive ring on vaginal microbiota, hiv shedding and local immunity

Conditions: Bacterial Vaginosis; HIV

Summary: the investigators propose to explore the hypothesis-supported by limited data-that a contraceptive vaginal ring (cvr) that is commonly used in the united states, the nuvaring, will enhance women's genital and reproductive health. the investigators propose that this cvr will increase the bacteria that help the vaginal environment protect against infection by hiv and other stis, and that in women who already have hiv, use of the cvr will lower the quantity of hiv that is shed in the female genital tract.

the investigators objective is to study effects of a contraceptive vaginal ring (cvr) containing estrogen and progesterone (nuvaring) on vaginal bacteria, hiv shedding, and local immunity in women. the investigators will build on data that support a favorable effect of cvr on vaginal bacteria. bacterial vaginosis (bv) is found in \>50% of women in sub-saharan africa. bv significantly increases risk of hiv acquisition in, and hiv transmission to male partners from, hiv-infected women, genital hiv shedding, and viral set point in infected male partners. pregnancy is also an independent risk for hiv acquisition and transmission. contraception comprises critical biomedical prevention for women with or at risk for hiv. systemic depot progesterone-commonly used throughout africa-may independently increase risk of hiv acquisition and transmission. hormonal interventions preventing unintended pregnancy and promoting a protective vaginal microenvironment could synergistically reduce hiv risk especially combined with topical antiretrovirals (arv). the investigators propose nuvaring use may contribute to reduction in bv, pregnancy prevention, and decreased rates of hiv shedding in hiv-infected women. sustained vaginal delivery of contraceptive and arv prep as "multicomponent prevention" is a major focus for scientists but effects on the vaginal environment need careful definition before broad implementation. total duration of follow up is no more than 8 months, with 5 months of cvr usage.

Eligibility criteria:
inclusion criteria: * bv+ by amsel criteria * not intending to become pregnant over the course of the study * if hiv infected, not taking art * capable of providing written informed consent exclusion criteria: * current pregnancy * desire/intent to become pregnant over the course of the study * contraindications to hormonal contraceptive use * current cigarette smoking if age is older than 35 years * unable to comprehend consent material because of language barrier or psychological difficulty

Keywords: hiv contraceptive vaginal ring bacterial vaginosis
erector spinae plane block versus general anesthesia in breast cancer surgeries

Conditions: Analgesia

Summary: this study aims at comparing the analgesic efficacy and safety of bilevel erector spinae versus single level versus general anesthesia for breast cancer surgeries


Eligibility criteria:
inclusion criteria: * female * diagnosed with breast cancer exclusion criteria: * patient refusal * coagulation defects * bone metastases * abnormal kidney and/or liver function tests
positioning in wheelchair bound patients

Conditions: Neurological Disease

Summary: the choice of the most suitable chair as well as the improvement of the patient's positioning on this wheelchair is important to limit the discomfort, to prevent the risks of bedsores, the pains related to prolonged sitting and finally to support the interaction of the patient with its environment. the goal of this prospective, longitudinale, monocentric study is to evaluate the impact of standardized positioning in wheelchair-bound patients at risk of slipping. the main questions on the positioning actions are: * their actions impact of positioning actions on shear forces * their impact on sliding in the chair * their impact on the feeling of discomfort in the chair * their impact on the caregivers' feelings about the patient's difficulties (eating, transfers, sliding) participation in this study will involve an increase in the number of transfers required for shear sheet placement and removal, as well as the time required for ischial measurement and the time to complete the (tool for assessing wheelchair discomfort) tawc questionnaire.


Eligibility criteria:
inclusion criteria: * patient hospitalized for a minimum of 9 days (minimum 48-hour reflection period after information) * patient aged between 18 and 80 years, * patient with a sitting time in a wheelchair \> or equal to 1 hour, * patient with a neurological condition : multiple sclerosis, stroke, spinal cord injury, parkinson disease, neurodegenerative diseases... * patient informed of the study and having given his written consent, non inclusion criteria: * cognitive disorders that do not allow the understanding of instructions * patient with a pressure sore * pregnant or breastfeeding woman * patient under legal protection

Keywords: wheelchair seating discomfort
is there a relationship between previous exposure to general anesthesia and the development of alzheimer´s disease?

Conditions: Alzheimer´s Disease; General Anesthesia

Summary: the purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of alzheimer´s disease and controls without diagnosis, through studies of medical records. the investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of alzheimer´s disease.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of alzheimer´s disease * previous exposure to anesthesia exclusion criteria: * inability to retrieve medical records