Kornimate/medical-research-clean huggingface dataset:
a safety study of synt001 in participants with warm autoimmune hemolytic anemia (waiha)

Conditions: Warm Autoimmune Hemolytic Anemia

Summary: this main study objective was to evaluate the safety and tolerability of intravenous (iv) synt001 (alxn1830) in participants with waiha.

this study planned to evaluate 2 cohorts: cohort 1, up to 8 participants to receive iv doses of alxn1830 (synt001 dose 1); cohort 2, up to 12 participants to receive iv doses of alxn1830 (synt001 dose 2). this study was terminated after the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy were characterized in participants with waiha in cohort 1 (synt001 dose 1), before any participants were enrolled in cohort 2.

Eligibility criteria:
inclusion criteria: participants had to meet the following criteria to be included: * willing and able to read, understand, and sign an informed consent form * confirmed diagnosis of waiha by enrolling physician * must have used medically acceptable contraception exclusion criteria: participants who met any of the following criteria were excluded: * participant unable or unwilling to comply with the protocol * active non-hematologic malignancy or history of non-hematologic malignancy in the 3 years prior to screening (exclusive of non-melanoma skin cancer and cervical cancer in situ) * positive for human immunodeficiency virus or hepatitis c antibody * positive for hepatitis b surface antigen * any exposure to an investigational drug or device within the 30 days prior to screening * intravenous immunoglobulin treatment within 30 days of screening * plasmapheresis or immunoadsorption within 30 days of screening * participant had any current medical condition that, in the opinion of the investigator, may have compromised their safety or compliance, precluded successful conduct of the study, or interfered with interpretation of the results
manual therapy as a form of sensory discrimination in chronic low back pain

Conditions: Low Back Pain

Summary: this study evaluates whether different explanations given to patients with long lasting back pain influence a physical therapy treatment technique. half of the patients will receive an explanation of the proposed treatment technique focusing on how their joints are moving and not moving. the second half of the group will receive the same treatment technique as the first group, but their explanation of the technique's purpose will focus on how their brain interprets the information. the study aims to determine if patients have a different response to the treatment based on the words chosen to explain the technique.

traditional treatment provided by physical therapists to patients with chronic low back pain focuses on the biomechanical or anatomical impact to local tissues. recent research has shown that treatment effects may be more related to the understanding of the structural and functional changes in the brain of someone suffering from chronic low back pain. this research implicates that the patients understanding and interpretation of input to the brain may change the patient's perceived representation and interpretation of output of pain within the brain.

Eligibility criteria:
inclusion criteria: * adults over the age of 18 * presenting at physical therapy with a primary complaint of low back pain * low back pain being present for 6 months or more * fluent in english and willing to participate in the study. exclusion criteria: * medical precautions to the use of manual therapy (metal, skin lesions, etc.) * prior spine surgery * unable to lay prone for the treatment.

Keywords: pain brain plasticity education manual therapy straight leg raise remapping
immunemodulation in patients with minor head injury

Conditions: Head Trauma

Summary: the purpose of this study is to try to prove the worth of the two (2) serum proteins s-100 beta and nse in combination with a diagnostic algorithm to help to establish diagnosis in patients with minor head injury.


Eligibility criteria:
inclusion criteria: * minor head injury exclusion criteria: * severe head injury

Keywords: intracranial bleeding computed tomography scan
home management of malaria and pneumonia

Conditions: Malaria; Pneumonia

Summary: a well-implemented community-based program of early and appropriate treatment of fevers/malaria episodes and pneumonia,will improve child survival as measured by a reduction of the less than five mortality rate.

an integrated approach of home and community management of malaria and pneumonia may increase the proportion of children receiving prompt treatment; improve child survival as measured by a reduction of the under five mortality rate. to test this hypothesis, a cluster randomised controlled trial will be performed, involving children less than 5 years of age, in burkina faso using a community-based supplying community health workers (chws), a core group of mothers (kols) with coartem and cotrimoxazole specially packed in age-specific blisters containing a full course of treatment. the study will be carried out in 111 clusters of a rural district in burkina faso where malaria and pneumonia are two major mortality causes in under five mortality.

Eligibility criteria:
inclusion criteria: * living in one of the study cluster (villages) * no story of allergy to any of the study drugs * history of fever or body temperature \>= 38.5°c exclusion criteria: * signs of severity/complications like impaired consciousness, convulsions, fast breathing etc

Keywords: impact of home management of malaria and pneumonia on child mortality home management of malaria and pneumonia
the effect of motivational support program applied to adolescents on sleep quality and academic achievement

Conditions: High School 11th Grade Students; Absence of Any Language, Hearing, Mental or Psychological Disability; Turkish Speaking and Understanding; Having a PUKI Index Above 5ı; Absence of Any Chronic Disease; Obtaining Permission From Parents and Students

Summary: it was planned as a randomized controlled experimental study with a single-blind technique, pretest-posttest control group and repetitive measurements, in order to determine the effect of motivational support program applied to adolescents and education on sleep quality.


Eligibility criteria:
inclusion criteria: * no language disorders * no hearing disorders * no mental disorders * bad sleep quality * no chronic disease exclusion criteria: * sleeping pill * psychiatric illness
a multi-center acute efficacy trial of gfx for reduction of glabellar furrowing

Conditions: Glabellar Furrowing; Forehead Wrinkles

Summary: the purpose of this research study is to evaluate the immediate effectiveness of the gfx™ device in reducing the furrows (deep frown lines) between eyebrows (glabellar region).

the purpose of this research study is to evaluate the acute ability of gfx to reduce glabellar furrowing. patients who have presented to the investigator for correction of glabellar furrows, as classified per the rated numeric kinetic line scale score for facial wrinkles secondary to hyperkinetic function (note: class 1 or higher)7 (appendix n) are candidates for this study. all patients must consent to the procedure and agree to complete their post treatment evaluation visit.

Eligibility criteria:
inclusion criteria: * has no medical contraindication * presenting for correction of glabellar furrows, as classified per the rated numeric kinetic line scale score for facial wrinkles secondary to hyperkinetic function (class 1 or higher) are candidates for this study * is at least 18 years of age * signs a written informed consent * understands and accepts the obligation to present for the scheduled follow-up visit * understands that the gfx procedure may not be successful. exclusion criteria: * has had an injection of botulinum toxin to the target area within the previous 3 months and still exhibits a positive cosmetic effect to the glabellar furrow * has had silicone, fat, collagen or a synthetic material placed in the glabellar region or surgical correction or excision of the glabellar furrows * has a known bleeding disorder * has received or is anticipated to receive anti-platelets, anti-coagulants thrombolytics or cancer therapy * is receiving systemic corticosteroids or anabolic steroids (standard doses of inhaled or nasal corticosteroids are acceptable) * has a history of chronic or recurrent infection or compromised immune system * has severe allergies manifested by a history of anaphylaxis * has known lidocaine hypersensitivity * is enrolled in another study * is pregnant * has history of keloid formation * the investigator believes the patient is not a suitable candidate for the gfx procedure, or is not likely to receive cosmetic benefit.

Keywords: glabellar furrowing
internet-administered interpersonal psychotherapy for depressive symptoms

Conditions: Major Depressive Disorder

Summary: the aim of the study is to test the efficacy of a treatment for depression based on interpersonal psychotherapy (ipt). the treatment will be accessed via an internet platform built for this study. a therapist will provide support weekly, as well as on-demand when needed. the treatment lasts for 10 weeks.


Eligibility criteria:
inclusion criteria: * a diagnosis of major depressive disorder (as indicated by the mini 7.0 neuropsychiatric interview) and/or depressive symptoms equal to or more severe than mild depression on the madrs-s (equal to or above 13 points) and/or bdi (equal to or above 14 points). * age of at least 18 years old. * adequate ability to speak, write, and read swedish. * internet access for the duration of the study. exclusion criteria: * ongoing substance abuse. * suicidal plans. * a diagnosed personality syndrome (as diagnosed before the study by a licensed psychiatric healthcare professional). * other ongoing psychological treatment. * other severe psychiatric comorbidity that requires specialized care (e.g. anorexia nervosa, psychosis). * recent changes in psychotropic medication or planned changes during the initial treatment period.

Keywords: interpersonal psychotherapy major depressive disorder internet intervention internet-based psychotherapy
frameless stereotactic radiosurgery for brain metastases

Conditions: Brain Metastases

Summary: the investigators plan to study high dose, single treatment radiation, using a plastic mask instead of a head frame that pins into a patient's skull. the investigators need to (1) quantify set-up accuracy and patient motion during radiation treatment and (2) ensure that without the head frame the tumour control rate and risk of complications are similar to our previous experience using the head frame.


Eligibility criteria:
inclusion criteria: * patients with brain metastases from a biopsy-proven primary extra-cranial tumor site, excluding lymphoma, germ cell, and small cell lung carcinoma histologies. * one to four metastases, and all lesions \< 3.5 cm in maximal diameter. extracranial metastases is of minimal volume or stable with treatment. - karnofsky performance status ≥ 70 exclusion criteria: * none of the lesions is abutting or within critical neurological structures: \*brainstem * optic chiasm * eye, and optic nerve. * the clearance between metastatic lesions and all critical structures must be at least 2 mm. * patients must not have leptomeningeal disease. * contraindications to imaging or radiation (e.g. pregnancy, elevated serum creatinine, allergy to contrast agents, severe claustrophobia, metal particles in the eye).

Keywords: radiosurgery frameless radiosurgery accuracy
accuracy of aobp in a chinese population

Conditions: Hypertension

Summary: background: traditional office blood pressure (bp) measurement is often inaccurate and is inferior to out-of-office measurements, such as ambulatory blood pressure monitoring (abpm), in predicting cardiovascular outcomes. a relatively new bp measurement method, called automatic office blood pressure measurement (aobp), may provide similar bp readings to abpm (latest clinical gold standard for bp measurements) and can easily be conducted in clinics. aobp machines measure bp repeatedly 3-5 times with 1-min intervals and automatically provide the mean bp value. while aobp was used in landmark trials (e.g. sprint trial) and was shown to eliminate white-coat effect, aobp is rarely used in hong kong partly because there is no data concerning the accuracy of aobp in chinese. almost all previous aobp research used bptru (aobp model), but bptru manufacturer was shut down permanently. aim: to assess if watchbp office (another aobp model) has superior diagnostic accuracy than traditional office bp measurements, when compared to abpm readings. method: 150 chinese adult patients with a diagnosis of essential hypertension will be recruited consecutively from a government-funded primary care clinic. all patients will have their bp measured by a 48-hour abpm, a watchbp office, and two traditional office blood pressure measurements. abpm will be considered the gold standard; sensitivity, specificity, positive and negative predictive values of aobp and traditional bp to diagnose elevated bp level, masked hypertension and white-coat hypertension will be calculated and compared implication: if watchbp provides closer bp readings to abpm, this can lead to its implementation in routine clinical practice


Eligibility criteria:
inclusion criteria: * diagnosis of essential hypertension exclusion criteria: * (i) severe hypertension as defined by clinical systolic bp ≥180 mmhg and/or diastolic bp ≥110 mmhg (because they may need emergency treatment and it is unethical to delay such treatment due to the proposed project), (ii) inability to provide consent, (iii) pregnancy, (iv) night-time occupations (we need to compare aobp and clinic bp readings to daytime abpm average when the patient should be awake), (v) are occupational drivers (because potential dangers in driving could occur when patients are asked to remain still), (vi) receiving anti-coagulants (to prevent bruises when using abpm), (vii) with known atrial fibrillation (as abpms and aobp use have not been validated in this group)

Keywords: aobp abpm
identification of new genes implicated in rare neurosensory diseases by whole exome sequencing

Conditions: Neurosensory Diseases; Retinopathy; Hearing Loss

Summary: next generation sequencing (ngs) strategy is a powerful tool to identify genes implicated in very rare diseases for which the previous genetic explorations remain negative to date. the aim of this project is based on groups of patients with original clinical phenotypes including neurosensory impairment without genetic cause identified to date. the investigators will study these families using whole exome sequencing to potentially identify new genes and new underlying biological pathways involved in neurosensory diseases.


Eligibility criteria:
inclusion criteria: * original phenotype with neurosensory diseases * written, informed consent obtained exclusion criteria: * refusal to participate at the study * prior inclusion in a similar study (ngs)

Keywords: whole exome sequencing
genetic polymorphism and parkinson's disease in taiwanese

Conditions: Parkinson's Disease

Summary: to observe and analyze the correlation between single nucleotide polymorphisms (snps) and the incidence of parkinson's disease in taiwanese.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson's disease (case subjects are diagnosed by the presence of at least three of the five following primary signs: rest tremor, bradykinesia, rigidity, impaired postural refluxes, and the presence of a sustained l-dopa response.) * healthy volunteers without parkinson's disease exclusion criteria: * cases showing atypical features, including multiple system atrophy and progressive supranuclear gaze palsy, or secondary causes of parkinsonism, such as neuroleptic drugs, infection, tumor, previous cerebrovascular accident and known toxins

Keywords: parkinson's disease genetic polymorphism
qui gong programme vs short form sun style tai chi in copd patients

Conditions: COPD

Summary: this was a randomized control trial. purposive sampling was done to obtained sample (n=78) which were randomly allocated to group a (n=39) and group b (n=39). study was conducted from august 2019 to december 2019 in hbs hospital islamabad.to determine the effects of qigong vs. shot form sun style tai chi (sstc) on lung function, six min walk distance, dyspnea and quality of life in copd patients.

chronic obstructive pulmonary disease (copd) is characterized by persistent respiratory symptoms and air-ﬂow limitation. dyspnea is related with daily life activity. copd patients often suffer from dyspnea and exacerbation, which leads to inactivity, deconditioning, and poor functional capacity and quality of life. several interventions have been investigated with the aim of improving lung function, decreasing dyspnea symptoms and improving quality of life in this patient. tai chi, an exercise involving both upper and lower extremities, originated from china. tai chi is characterized by posture alignment, weight shifting and circular movements that incorporate elements of muscle endurance and strengthening, balance, relaxation and breathing control. among previous studies tai chi in pulmonary rehabilitation showed a modest complementary benefit in exercise capacity. the tai chi program is a safe, effective and feasible method to improve exercise capacity and health-related quality of life in people with copd. short form sun style tai chi is one of the most common styles of t'ai chi. each form can be broken down into several movements which make it easy to learn and teach. compared to some other styles of t'ai chi, sstc involves less difficult movements, such as less deep-knee bending and single leg standing, which may make it more suitable for older people. qi gong is defined as a mind-body exercise that involves whole body movements, breathing techniques, postural control, and internal awareness. effects of qi gong on functional capacity and lung functions in copd patients , and concluded that functional capacity, dyspnea scores and quality of life was significantly improved in mild to moderate copd patients.

Eligibility criteria:
inclusion criteria: * clinically diagnosed patient: mild to moderate stage copd according to gold criteria {i-e global initiative for chronic obstructive lung disease (gold) } * patients who can walk without any dependency were included in study. exclusion criteria: * patients with acute exacerbation within 4 weeks before starting the study * patient having significant, cognitive impairment * patient having tuberculosis, asthma * patient having musculoskeletal * patient having psychological, cardiovascular and benign conditions (that prohibit exercise were excluded from the study)

Keywords: pulmonary disease qigong tai chi
a randomized controlled evaluation of a compassion-course for healthcare professionals

Conditions: Psychological Stress; Compassion; Occupational Health; Cognitive Behavioral Therapy

Summary: the aim is to investigate whether an internet-based compassion course of five modules contributes to reducing stress of conscience and work-related stress, increase the experience of professional quality of life and self-compassion in healthcare professionals.

reactions to severe stress is one of the most common causes of sick leave in sweden. previous research has shown that compassion interventions for staff can affect work-related stress by increased self-care, better self-awareness and an increased healthy attitude, however, swedish studies on the subject are scarce. compassion is a motivation to reduce suffering in oneself and others characterized by a warm, understanding, and respectful attitude. in addition to beneficial effects for the staff, a compassion-oriented approach, has shown to improve the relationship between patient and staff, increase patient satisfaction with care and reduce patient anxiety and stress. as a result of the covid-19 pandemic, healthcare professionals have been exposed to difficult physical and mental work conditions that cause feelings of stress and inadequacy. in the long run, increased stress can cause fatigue and increased number of sick leaves. this can in turn contribute to increased stress for the staff who remain working and difficulties to recruit new staff, which make the situation worse. there is a lack of interventions for staff aimed at preventing stress-related health issues, enabling recovery and reduce mental suffering linked to a stressful work situations. the aim of this study is to find a method that help healthcare providers cope with stress of conscience in relation to stressful work situations, particularly during the current covid-19 pandemic. a five week internet-based compassion course of five modules will be conducted and evaluated with the aim of exploring whether the course contributes to reduce stress of conscience and work-related stress, and increases the levels of professional quality of life and self-compassion among healthcare professionals. the internet-based compassion course will be compared with: one group that is on a waiting list for ten weeks and then receives an internet-based general stress management course and one group that participate in the general stress management course.

Eligibility criteria:
inclusion criteria: the inclusion criteria will be as follows: the participants work directly with patients full-time or part-time, score 45 points or higher on the primary outcome measure stress of conscience questionnaire (scq), are proficient in swedish, have the requisite time to attend a digital course, and accept the course's format. the exclusion criteria include being partially or fully on sick leave due to stress. all criteria are assessed on the basis of self-assessment forms of the participants, but in case of uncertainty, follow-up questions can be done by phone.
correction of breech presentation with laser acupuncture

Conditions: Breech Presentation

Summary: acupuncture-type interventions (such as moxibustion and acupuncture) at bladder 67 (bl67, zhiyin point) have been proposed to have positive effects on breech presentation. however, the role of laser acupuncture for breech presentation remains unknown. the aim of this study is to evaluate the effectiveness and safety of laser acupuncture in correcting breech presentation.


Eligibility criteria:
inclusion criteria: * breech presentation or non-cephalic presentation * gestation age 28\~34 weeks * singleton exclusion criteria: * uterus anomaly * uterus tumors * risk of preterm labor