Kornimate/medical-research-clean huggingface dataset:
saccharomyces boulardii in diarrhea dominant irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: probiotics are friendly bacteria normally present in food products like yogurt whereas irritable bowel syndrome is a longstanding functional disorder characterized by abdominal pain and altered bowel habits either diarrhea or constipation dominant without a definitive etiology. study hypothesis:does probiotics(saccharomyces boulardii improves daily bowel symptoms and quality of life in patients with diarrhea dominant irritable bowel syndrome?

irritable bowel syndrome (ibs) is a common functional disorder and may lead to impaired social and personal function and can diminish quality of life.while the precise pathophysiology of ibs remains to be elucidated, dysmotility and altered visceral sensory perception are currently the most popular hypothesis. there has been a suggestion that some patients with ibs may harbor bacterial overgrowth leading to low grade inflammation, immune activation, and their symptoms may be ameliorated by its eradication.probiotics, defined as live or attenuated bacteria or micro organism that confer a significant health benefit to the host. * i. firstly, probiotic organism exert antibacterial and antiviral effects. * ii. probiotics could alter the composition of the gut flora, either directly through augmentation of commensal or indirectly through a reduction in pathogen related inflammation or bacterial fermentation. trial protocol: phase 1: placebo bid (1 week),both arms phase 2: randomization by pharmacy, placebo vs. active drug (6 weeks) phase 3: placebo bid (1 week), both arms -iii. probiotics have been demonstrated to exert anti-inflammatory effects at mucosal surfaces by reducing mucosal inflammation, decreasing immune mediated activation of enteric motor and sensory neurons and modifying neural traffic between the gut and central nervous system. saccharomyces boulardii is a probiotic yeast and its role for the treatment of ibs has not been extensively investigated.

Eligibility criteria:
inclusion criteria: * patients will be recruited from gastroenterology clinic at aga khan university hospital with diagnosis of diarrhea dominant irritable syndrome. * age between 18- 60 years. * male and female both. * organic gastrointestinal diseases excluded by baseline laboratory and sigmoidoscopy/colonoscopy and biopsy within last 2 years. * all patients need to satisfy rome iii criteria exclusion criteria: * age \ 60 years * pregnant and lactating females * patients on laxatives or antidiarrheal drugs that could influence the motility of gut * patient on antibiotics or within 2 weeks of starting protocol. * not willing to participate * non-compliant in run in period. * patients taking husk. * diabetic patients

Keywords: irritable bowel syndrome diarrhea probiotics
implementing and sustaining a transdiagnostic sleep and circadian treatment

Conditions: Sleep Disorders, Circadian Rhythm; Sleep Disorder; Acceptability; Feasibility; Adaptation; Implementation Research

Summary: the goal is to collect pilot data on an adapted version of the transdiagnostic sleep and circadian intervention (trans-c), referred to as 'fitted trans-c'.

mental illness is often severe, chronic and difficult to treat. the sleep disturbance commonly experienced by individuals with a severe mental illness reduces capacity to function and contributes to key symptoms. this study seeks to collect pilot data on an adapted version of the transdiagnostic sleep and circadian intervention (trans-c). the adapted version will be referred to as 'fitted trans-c' as it is designed to improve the fit to delivery within community mental health centers. 'fitted' treatments are needed because the context for implementation (community setting) typically differs from the original testing context (university setting) causing a lack of 'fit' between the setting and evidence based treatments.

Eligibility criteria:
inclusion criteria: * can understand treatment in english * is not currently at risk for suicide or homicide * has not worked the night shift more than 2 nights per week in the past 3 months * is not pregnant or nursing * has a guaranteed bed to sleep in for the next month, which is not a shelter. exclusion criteria: * at risk for suicide or homicide * has worked the night shift more than 2 nights per week in the past 3 months * is pregnant or nursing * does not have a guaranteed bed to sleep in for the next month

Keywords: circadian rhythm disorders sleep disorders acceptability adaptation feasibility
value-based emotion-focused educational programme to reduce diabetes-related distress

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of the clinical trial is to evaluate the effectiveness of a relatively simple and short value-based emotion-focused educational programme in adults with type 2 diabetes (vemofit) on diabetes-related distress, depressive symptoms, illness perception, medication adherence, quality of life, diabetes self-efficacy, self-care and clinical outcomes.

type 2 diabetes (t2d) patients experience many psychosocial problems related to their diabetes, as well as social- and work-related relationships. these often lead to emotional disorders such as distress, stress, anxiety and depression. without proper care, these patients use more often negative coping strategies and more frequently expect that their diabetes will negatively affect their future. a cluster randomised controlled trial will be conducted in 10 public health clinics (hc) in malaysia. these clusters are eligible if they are providing standard diabetes care according to national clinical practice guidelines, not involved in similar trial and having nurses to be trained to deliver the vemofit educational programmes. pre-stratification by cluster size and geographic areas of the hcs will get randomised five hcs to the vemofit group (vg) and attention-meetings group (ag), respectively.

Eligibility criteria:
inclusion criteria: * malay patients * diagnosed with t2d for at least two years * on regular follow-up with at least three visits in the past one year * have diabetes-related distress (mean dds-17 score ≥ 3) * showing poor disease control (not reaching targets for one of the three biomarkers, namely hba1c ≥ 8%, blood pressure ≥ 140/90 mmhg and ldl-c \> 2.6 mmol/l) exclusion criteria: * patients who are enrolled in other clinical studies * pregnant or lactating * having psychiatric/ psychological disorders that could impair judgments and memory * patients who cannot read or understand english or malay * patients who scored ≥ 20 on the patient health questionnaire-9 (phq-9) that suggest a severe depression

Keywords: mood disorders self care primary care
comparisons of urodynamic, bladder diary, quality of life parameters between oab-wet and oab-dry female patients

Conditions: Urinary Bladder, Overactive

Summary: a small bladder capacity and more frequent urgency episodes were predictors of oab-wet, and the above findings might indicate that oab-wet and oab-dry are a continuum of oab. older age, high maximum flow rate, high detrusor pressure at maximum flow rate and the presence of urodynamic stress incontinence were also independent predictors for oab-wet, and the above might indicate that oab-wet and oab-dry have at least partly different underlying pathophysiologies.

aims: to identify factors predicting the presence of oab-wet and to further derive the underlying pathophysiology in oab-wet vs. oab-dry. methods: between september 2007 and september 2013, the medical records of women with oab who completed a 3-day bladder diary and underwent urodynamic studies in a tertiary referral center will be reviewed. oab-wet will be diagnosed in patients who complained of at least one episode of urgency incontinence in the previous month; otherwise, oab-dry is diagnosed. multivariate logistic regression analysis will be used to predict the presence of oab-wet.

Eligibility criteria:
inclusion criteria: 1. the diagnosis of overactive bladder disease 2. female patient of more than 20 year-old exclusion criteria: 1. dominant symptoms with stress urinary incontinence (sui) 2. regular urethral catheterization or intermittent self-catheterization 3. urinary tract infection or chronic inflammation in the previous 2 weeks 4. bladder calculus 5. a history of pelvic radiotherapy 6. a preexisting malignant pelvic tumor.

Keywords: urinary bladder, overactive urinary incontinence, urge urodynamics
attitudes of general practitioners in lorraine towards prediabetes

Conditions: PreDiabetes

Summary: screening for the risk factors of type 2 diabetes is a part of the primary prevention approach. pre-diabetes is one of the modifiable risk factors; however, it remains under-diagnosed. our aim was to analyse the attitudes of general practitioners in lorraine towards prediabetes


Eligibility criteria:
inclusion criteria: * general practitioner * practice in lorraine * installed or substitute * exclusively private practice or mixed activity exclusion criteria: * retired physicians * general practitioners working exclusively in hospital
botulinum toxin a for emotional stabilization in borderline personality disorder (bpd)

Conditions: Borderline Personality Disorder

Summary: the main objective of the trial is to test whether a single application of botulinum toxin a into the glabellar region will lead to emotional stabilization in borderline personality disorder through paralysis of facial muscles/attenuation of negative emotions.

afferent feedback from facial muscles is believed to enhance emotional states (facial feedback theory). the facial expression of negative emotions involves facial muscles of the glabellar region. it has been shown that paralysis of facial muscles in the forehead using botulinum toxin a leads to the improvement of depressive symptoms. it is believed that the limited ability to express these emotions alleviates depressive symptoms. as borderline personality disorder is characterized by negative emotions expressed via facial muscles in the forehead, it is hypothesized that bpd patients could profit from botulinum toxin treatment.

Eligibility criteria:
inclusion criteria: 1. female 2. 18-40 years 3. diagnosed bpd according to icd-10 (f60.31) and skid ii 4. stable treatment 5. mastery of the german language 6. effective contraception 7. willingness to and acceptance of treatment with either botulinum toxin a or acupuncture exclusion criteria: 1. comorbid disorders of all icd-10 groups o f0, * f1 (with exception of f1x.1), * f2, * f3 (with exception of 32.0 and f33.0), * f7 and disorders essentially defining the clinical picture from sections * f4, * f5, * f6. 2. contraindication for treatment with botulinum toxin a according to the imp's smpc (e.g. myasthenia gravis, lambert eaton-syndrome or other impairments in neuromuscular function)
wearable pulsed electromagnetic fields device in knee osteoarthritis: double blinded, randomized clinical trial

Conditions: Knee Osteoarthritis

Summary: the aim of the study is to evaluate the efficacy of a wearable device using pulse electromagnetic fields on pain intensity reduction, measured by visual analogue score (vas) and western ontario and mcmaster universities osteoarthritis index (womac), in patients affected by osteoarthritis secondary aim is the evaluate the effect on knee effusion reduction, when present and to evaluate pain intensity changes corrected by pain threshold measured by pressure algometry.


Eligibility criteria:
inclusion criteria: * a diagnosis of primary oa of the knee according to the acr criteria, including radiologic evidence of oa * age \>40 years * symptomatic disease for at least 6 months prior to enrollment * persistent pain despite receiving the maximum tolerated doses of conventional medical therapy, including acetaminophen (4 gm/day) and/or a nonsteroidal antiinflammatory drug (nsaid), with persistent pain defined as a minimum mean score of 25 mm on the visual analog scales (vas) for global pain (0-100-mm range for each) daily pain during the month prior to study enrollment * ability to attend followup appointments exclusion criteria: * secondary causes of oa * local or systemic infection * diabetes mellitus * systemic arthritis * allergy to anesthetic agent or contrast material * coagulopathy * anticoagulant therapy * had previous ia steroid injection * avascular necrosis of bone * patients who are on specific oa pharmacological therapy (nsaids, opioids) for more than 2 weeks prior enrollment

Keywords: osteoarthritis pulsed electromagnetic fields device pain pressure algometry
dissociative disorders in obesity (dissobe)

Conditions: Obesity; Dissociative Disorder

Summary: the aim of this study is to determine the frequency of dissociative tendencies in the obese population treated at the celiobe (liberal center for obesity support) at hôpital privé la louvière among patients consulting for the first time and looking for a medical or surgical course. the des scale of carlson and putman will be used.


Eligibility criteria:
inclusion criteria: * age over 18 * obesity defined by a body mass index (bmi) ≥ 30 kg / m2 * patient seen in consultation at celiobe for the first time for the management of an overweight problem, wishing for surgical or medical care * patient having been informed and not opposing to this research * patient affiliated or beneficiary of a social security scheme exclusion criteria: * psychotic antecedents: schizophrenia, schizoaffective disorders, hallucinatory psychoses, brief psychotic attacks * addictive behaviors (alcohol, drug addiction) * drug use * taking antipsychotics and mood stabilizers * dissociative identity disorders proven * bipolar disorders or severe mental illness * understanding troubles * protected patient: major under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision; hospitalized without consent * pregnant, breastfeeding or parturient woman
comparison of efficacy of little lovely dentist, dental song and tell-show-do techniques in alleviating dental anxiety in paediatric patients

Conditions: Anxiety; Paediatric; Dental Anxiety; Behaviour

Summary: to evaluate the efficacy of different techniques for the reduction of dental anxiety in pediatric patients. generally, anxiety amongst paediatric patients is higher as compared to adult patients. so different modalities are used by the dentists in order to reduce the anxiety of such patient to help to make treatment procedures easier and optimal.

children who suffer from dental anxiety avoid any sort of dental treatment provided to them, which leads to poor oral hygiene, and if unaddressed, problems like missing teeth and decayed teeth further in life develop, and ultimately leading to problems making treatment planning intricate. children normally follow the footsteps of their parents so it is of importance to consider how to avoid creating dental anxiety among them. if dental anxiety is left untreated, it might persist during adulthood, which eventually will deteriorate the oral health of such patients. due to the substantial effect of dental anxiety in paediatric patients, many methods have been devised to alleviate or eliminate such anxieties of the patients. this study aimed to employ different strategies and measure heart rate and facial image scale scores to determine their efficacy in reducing paediatric patient's dental anxiety by using these techniques before and after the procedure to compare the effectiveness of each of these techniques.

Eligibility criteria:
inclusion criteria: * only the children age ranged from 4 to 11 years with no positive medical history. exclusion criteria: * rest were excluded.

Keywords: anxiety dental application dental song tell-show-do behaviour
clinical results of arthroscopic-assisted lower trapezius tendon transfer for massive, irreparable rotator cuff tears

Conditions: Massive Irreparable Rotator Cuff Tears

Summary: this study aimed to describe a modified technique for arthroscopic-assisted transfer of the lower trapezius tendon in a selected group of patients with irreparable rotator cuff tears and to evaluate its short-term results.

patients scheduled for surgery will undergo evaluation one day before the surgical procedure and again at the six-month postoperative mark. pain intensity will be assessed using the visual analog scale (vas), while shoulder function will be evaluated using both the university of california, los angeles (ucla) shoulder score and the constant-murley shoulder score.

Eligibility criteria:
inclusion criteria: * patients with massive, chronic (\>6 months), irreparable rotator cuff tears; * patients with no concomitant irreparable subscapularis tears; * patients who underwent a trial of at least 6-month period of conservative treatment with no benefit; * patients with a stage 3 or greater degree of supraspinatus muscle fatty infiltration; exclusion criteria: * patients with glenohumeral arthritis; * patients with adhesive capsulitis or passive joint motion restriction * patients with neurologic deficits

Keywords: irreparable rotator cuff tears tendon transfer massive rotator cuff tears
intradialytic pedalling exercise and vascular hemodynamic parameters among prevalent hemodialysis population

Conditions: Chronic Kidney Disease Requiring Chronic Dialysis

Summary: the purpose of this pilot study is to evaluate 1) the effect of intradialytic pedaling exercise on arterial stiffness and other arterial hemodynamic parameters over 4 months, and 2) the longer-term effect of pedaling on arterial stiffness and other arterial hemodynamic parameters 4 months after finishing the exercise intervention (8 months after study initiation). the investigators also aim to examine the impact of intradialytic pedaling exercise on general health, anthropometric measures, physical function, and routine laboratory blood markers as secondary outcome measures, as well as to assess feasibility, safety and adverse events associated with the intradialytic pedalling exercise. recruitment of more participants in the future will be considered if warranted.


Eligibility criteria:
inclusion criteria: * adults with end-stage renal disease (stage 5 ckd), who were on a stable in-center hemodialysis regimen (approximately 4 hours 3 times per week) for ≥ 12 weeks prior to recruitment * a cardiac evaluation was required within the last year to ensure adequate cardiac function exclusion criteria: * any physical or psychological disability that would impact study participation, such as severe cerebrovascular disease (e.g., hemiparesis, cerebellar ataxia, etc.) or dementia * serum intact parathyroid hormone(ipth)\>250 pmol/l within 30 days prior to screening visit * dysrhythmia or severe cardiac disease, such as congestive heart failure (chf) class iii-iv, or unstable cardiovascular disease within 90 days prior to recruitment * severe peripheral arterial disease * severe hyperkalemia (\>6.5 milliequivalent/l) consistently the last 2 weeks * current active cancer (excluding basal cell carcinoma of the skin) * poorly controlled hypertension (post-dialytic systolic blood pressure ≥ 160mmhg or diastolic blood pressure≥ 100 mmhg) within 4 weeks prior to recruitment * anticipated living donor kidney transplant or any other planned major surgery over the study duration * history of poor treatment adherence

Keywords: arterial stiffness hemodialysis intradialytic pedalling exercise carotid-femoral pulse wave velocity chronic kidney disease hemodynamics augmentation index
taste test between desloratadine and cetirizine syrup in children (study p03829)(completed)

Conditions: Allergic Rhinitis

Summary: this study was conducted to compare the taste acceptability of zyrtec syrup with desloratadine syrup in children. children between 6 and 11 years of age received 5 ml of each syrup, separated by 15 to 20 minutes on a single day.

this study is a cross-over study design.

Eligibility criteria:
inclusion criteria: subjects must be: * between 6 and 11 years of age in good general health * premenarcheal if female exclusion criteria: subjects who: * have known allergies or sensitivities to either of the drug formulations * have a medical condition that may interfere with the subject's ability to discriminate between tastes * have used any antihistamines within 24 hours prior to dosing * were taking sedatives, tranquilizers, or monoamine oxidase inhibitor drugs * were involved in another clinical or market research study within the past 30 days
the effect of reiki application on stress and anxiety levels

Conditions: Stress

Summary: the aim of this study is to determine the effect of reiki practice on stress and anxiety levels in nurses.

it was a randomized controlled trial. reiki was applied to the participants in the experimental group twice a week for two weeks. no intervention was applied to the participants in the control group.

Eligibility criteria:
inclusion criteria: * volunteer nurses were included in the research exclusion criteria: * nurses, who had previous reiki experience and did not agree to participate in the study, were excluded

Keywords: anxiety nursing reiki perceived stress
st. john's wort extract li 160 for the treatment of atypical depression

Conditions: Atypical Depression

Summary: the aim of tis study is to assess the efficacy and safety of jarsin® 300 mg as an acute treatment in mild to moderate depression with atypical features.

the general picture of depression is still that of the traditionally called endogenous type, which is also the form that was characterized extensively in clinical trials. atypical depression with reversed vegetative signs, such as hyperphagia or hypersomnia, is traditionalla neglected, demonstrated by the fact that in the most widely used depression scales, such as the hamilton depression scale, melancholic symptoms have a specific weight, while, by contrast, reversed vegetative signs are not included. this etablishes a tendency to underestimate the severity of atypical depression.

Eligibility criteria:
main inclusion criteria: * mild to moderate depression (icd-10 f32.0, f32.1) with atypical features according to dsm-iv, lasting at least 3 months * female and male caucasians aged 18 to 70 years * at least one of hamd-28 scale items 22-26 scores \>1

Keywords: mild to moderate depression with atypical features according to dsm-iv