Kornimate/medical-research-clean huggingface dataset:
acupuncture for cipn in breast cancer patients

Conditions: Sensation Disorders; Neuropathy

Summary: the aim of this study is to collect preliminary data on the effectiveness of acupuncture for the treatment of cipn in breast cancer patients.

ideally 10 patients experiencing peripheral neuropathy due to chemotherapy from breast cancer treatment will be included in this study.they will receive 16 total acupuncture treatments over 10 weeks including various points based off of research and classical text and scalp acupuncture.

Eligibility criteria:
inclusion criteria: 1. minimum of 18 years of age 2. currently receiving neurotoxic chemotherapy 3. experiencing symptoms of chemotherapy induced neuropathy for at least 1 month 4. have a minimum score of 3 on the vas should have a grade ii cipn on ncictc 5. willing to sign an informed consent 6. stable treatment for more than two months before screening * stable treatment is defined as no change in the type and dose of medications 2 months prior to enrollment. * once enrolled, the patients will be asked to remain on the same type and dose of the medications for neuropathy exclusion criteria: 1. receiving any treatment to prevent neuropathy 2 weeks prior to the screening 2. pre-existing peripheral neuropathy due to any other cause than chemotherapy 3. pre-existing conditions like pregnancy, uncontrolled diabetes, hypertension, cardiovascular disorders, bleeding disorders, depression (bdi \> 21) 4. unwilling to follow the protocol 5. individuals who are receiving government disability assistance

Keywords: neuropathy peripheral chemotherapy breast cancer
real and sham diathermy vs hand massage in lower limbs delayed onset muscle soreness (doms)effect on knee proprioception

Conditions: Musculoskeletal Pain

Summary: delayed onset muscle soreness (doms) can have an impact on the proprioception of knee joint . the study aim is to assess the effect of manual massage, diathermy and sham diathermy the proprioception of the knee joint in patients affected by doms.

delayed onset muscle soreness (doms) can have an impact on the proprioception of knee joint. the study aim is to assess the effect of manual massage, diathermy and sham diathermy on the proprioception of the knee joint in patients affected by doms. proprioception will be measured with "technique" an app available on appstore , on the basis of the work on knee proprioception by s m mir 2008 , and data about pain with numbering pain rating scale (nprs) and pre-post treatment and global impression of change (pgic) will be acquired.

Eligibility criteria:
inclusion criteria: * patients with doms after a skimountaineering race exclusion criteria: * comorbidities, trauma

Keywords: proprioception doms pain massage diathermy
prevention of head impacts in football: the hutt technique

Conditions: Head Trauma; Cognitive Manifestations

Summary: the purpose of the study is to determine the effectiveness of the helmet-less tackling training (the hutt technique) intervention to reduce head impacts in high school football players and to gain an understanding of the neurocognitive effects of repetitive head impacts in football. the investigators hypothesis is that the hutt technique will result in a reduced frequency and magnitude of helmet impacts than the control group measured by a head impact measurement system. also, the investigators hypothesize the hutt technique group will demonstrate less changes in neurocognitive scores in the mid and post season evaluations compared to the control group. head impacts will be measured using the sim-g impact monitor made by triax technology. the sim-g impact monitor measures the location, magnitude, and direction of every head impact in real time and is stored on a protected cloud-based system. the sensor is worn by each athlete in a headband or skullcap. neurocognitive function will be measured using the immediate post-concussion assessment and cognitive testing (impact) test. the test is used as a tool to determine baseline neurocognitive function and is used in comparison if an athlete was to be injured to ensure he/she returns to baseline. impact measures memory (verbal, visual, working), processing speed and reaction time using a variety of tests. subjects will be recruited from local high school football teams and will include freshman, sophomores and juniors. since the study is expected to run for 2 years, seniors will not be eligible for participation. the target is to recruit at least 150 total subjects. all subjects will be equipped with a new helmet that is fitted to their head and a headband that will be used to hold the head impact telemetry sensor. in addition, all subjects will take an impact test preseason, midseason and postseason. at the conclusion of each season, all of the impacts from the sim-g impact monitor system and impact test scores will be analyzed. the relevant outcome measures to be analyzed include head impact frequency, location, magnitude, symptom scores, memory, visual motor speed and reaction time composite scores. statistical analysis will be used to determine if the hutt intervention minimized head impacts and neurocognitive decline compared to the control group.


Eligibility criteria:
inclusion criteria: * high school football participant * two years eligibility exclusion criteria: * one year eligibility (high school senior) * use of a riddell speed "flex" helmet

Keywords: football training techniques education athletic injuries brain concussion
the postprandial calcium absorption of a milk derived calcium permeate - renew acute study

Conditions: Osteoporosis

Summary: this is a randomized controlled cross-over meal study with the overall aim to investigate the postprandial calcium absorption from calcium permeate compared with calcium carbonate. the hypothesis is that the bioavailability of calcium permeate is equal to or higher than calcium carbonate. this will be investigated in a cross-over design with 10 postmenopausal women age 50-65 as subjects.


Eligibility criteria:
inclusion criteria: * subject is \>50 years and \<65 years of age by the time of inclusion. * subject has been menopausal for 2-5 years. * subject willing and able to meet at university hospital, køge for three whole days in one month. * subject is non-smoking or able not to smoke during clinic visits. * subject with no history of osteoporotic fractures. * subject is willing and able to provide written informed consent prior to participation. exclusion criteria: * subject taking supplements or medicine that affects calcium and bone metabolism e.g. diuretics or hormone replacement therapy. * subject with vitamin d insufficiency defined as ≤50nmol/l. * subject with an osteoporosis diagnosis. * presence of renal, gastrointestinal, hepatic or endocrinological diseases. * subject with any serious illness e.g. cancer. * subject with lactose intolerance. * subject with celiac disease. * known or suspected abuse of alcohol or recreational drugs. * known or suspected hypersensitivity to trial products or related products. * subject where it is not possible to obtain sufficient data.
trial of epinephrine and albuterol in bronchiolitis

Conditions: Bronchiolitis

Summary: the purpose of this study is to see which of the two most common drugs used to treat bronchiolitis works better. a child's participation in this study is expected to last less than 4 hours. approximately 600 patients will be recruited to participate in this study at kern medical center (kmc). bronchiolitis is a very common lung infection in babies. there are many drugs used to treat this disease but nobody knows which one, if any, works the best. two of the most commonly used drugs are albuterol and epinephrine. these are both drugs given during breathing treatments with oxygen and a mask. we are doing this study to see which of these drugs works better or if they are both equally good. the study works as follows: after the consent process the baby gets three treatments. * nebulizer 1 (treatment) * treatment + 30 minutes (approximately) nebulizer 2 * treatment + 60 minutes (approximately) nebulizer 3 * treatment + 120 minutes (approximately) the baby will be reevaluated and either discharged home or revert to standard therapy. if the baby is discharged directly from the emergency department (e.d.), we will call you in three days time to see how he/she is doing.

double blind rct. primary outcome measure is admission defined as actual admission or discharge with unscheduled return leading to admission within 72 hours. secondary endpoints include change in severity of illness and response of respiratory parameters to treatment.

Eligibility criteria:
inclusion criteria: * a clinical diagnosis of bronchiolitis exclusion criteria: * age greater than 18 months * disease too mild to warrant any treatment * emergent intubation on arrival at the ed * participation within another study within 30 days * refusal of informed parental consent

Keywords: bronchiolitis disposition pediatric epinephrine albuterol
understanding engagement trends in chondrosarcoma clinical trials

Conditions: Chondrosarcoma

Summary: taking part in medical research usually favors a particular demographic group. but there is limited research available to explain what trial attributes affect the completion of these specific demographic groups. this study will admit a wide range of data on the clinical trial experience of chondrosarcoma patients to determine which factors prevail in limiting a patient's ability to join or finish a trial. it will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future chondrosarcoma patients.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years old * able to comprehend the investigational nature of the protocol and provide informed consent * diagnosis of chondrosarcoma exclusion criteria: * no diagnosis of chondrosarcoma confirmed * inability to perform regular electronic reporting * patient does not understand, sign, and return consent form

Keywords: chondrosarcoma
effect of prehabilitation during the conversion therapy on postoperative outcomes in unresectable hepatocellular carcinoma

Conditions: Advanced Hepatocellular Carcinoma (HCC); Prehabilitation

Summary: this is a prospective, randomised controlled clinical trial to study the impact of prehabilitation on postoperative complications, physical function, quality of life, and short-term survival outcomes in patients with unresectable liver cancer undergoing conversion therapy.


Eligibility criteria:
inclusion criteria: 1. patients must be aged between 18 and 75 years, inclusive, with no gender restrictions. 2. patients must have an initial diagnosis of unresectable hepatocellular carcinoma (hcc) confirmed by easl/aasld diagnostic criteria, pathological histology, or cytology, and must be planned for conversion therapy. 3. patients must have an american society of anesthesiologists (asa) physical status classification of ≤iii. 4. patients must be physically capable of participating in exercise training, defined as the ability to walk continuously on flat ground for more than 200 meters without rest and to climb two flights of stairs consecutively without requiring a break. 5. patients must not have any psychiatric disorders, speech impediments, or consciousness disturbances, and must possess adequate comprehension, communication, and literacy skills. 6. patients must voluntarily enroll in the study, be able to provide written informed consent, and be capable of understanding and adhering to the trial protocol and follow-up procedures. - exclusion criteria: 1. a known diagnosis of cholangiocarcinoma, sarcomatoid hepatocellular carcinoma (hcc), combined hepatocellular carcinoma, or fibrolamellar carcinoma. 2. presence of extrahepatic metastases or concurrent other malignant tumors. 3. presence of psychiatric disorders or cognitive impairments that would impede compliance with study requirements. 4. unsuitability for participation in exercise training due to skeletal muscle diseases or a history of fracture within the past 6 months. 5. pregnant or breastfeeding women. 6. individuals with severe and irreversible cardiac, pulmonary, or renal organic diseases, or severe anemia, which would make them unsuitable for preoperative rehabilitation programs. -

Keywords: unresectable hepatocellular carcinoma prehabilitation conversion therapy
risk factors of complications after ileocolic resection for crohn disease according to the comprehensive complication index

Conditions: Crohn Disease; Ileocolic Resection

Summary: aim: the aim of this study was to investigate the risks factors of complications after ileocolic resection for crohn disease according to the comprenhensive complication index. methods: data collected between january 2010 and march 2020 will be analyzed. informations about preoperative, peroperative and post operative will be collected. the outcome after surgery will be analysed according to the comprehensive complication index.

there are several risk factors reported for postoperative complication after ileocolic resection for crohn disease. with recent new therapeutics (anti tnf, monoclonal antibodies), these criteria are questioned. according to the ecco 2010 consensus conference, five post-operative risk factors for recurrence of crohn disease were described: smoking, extensive small bowel resection (\> 50cm), repeat bowel resection, presence of ano-perineal lesions, and penetrating disease (type b3). however, postoperative complication risk factors after ileocolic resection remain debated. currently the place of a pre-operative treatment with anti-tnf seems to be a post-operative complication risk factor according to the last ecco 2017 consensus conference, as well as preoperative parenteral nutrition and emergency versus planned surgery. in addition, a recent getaid study seems to challenge the penetrating phenotype as a risk factor of postoperative complication. a current study could provide new data on the various known or suspected complication risk factors in the anti-tnf/monoclonal antibodies era. the classification of clavien dindo does not necessarily take into account the respective severities of each complication in a patients. the new classification (comprehensive complication index (cci)) could be usefull to take into account all the complications and their importance, without focusing only on the most important. to our knowledge, there is no study specifically evaluating cci after ileocolic resection for crohn disease. we believe that the cci can provide a more refined analysis of risk factors for postoperative complications after this procedure. the aim of this study is to analyze the different complication risk factors after ileocecal resection according to the recent comprehensive complication index, tools potentially more sensitive than clavien dindo classification to highlight differences in postoperative morbidity.

Eligibility criteria:
inclusion criteria: * patients who underwent an ileocolic resection for crohn disease * patient ≥18 years old exclusion criteria: - patient who reject the study protocol

Keywords: postoperative outcomes laparoscopy comprehensive complication index postoperative complications
virtual human delivered nutrition module for colorectal cancer prevention

Conditions: Colorectal Cancer

Summary: this study uses the opinions of adults between the ages of 45 and 73 years old to develop and test an interactive nutrition module for use in an existing colorectal cancer screening intervention using virtual human technology. the main questions answered include: * what content do adults want to receive from a web-based interaction about colorectal cancer screening and nutritional risks for colorectal cancer? * does a brief interaction with a virtual human delivering tailored cancer prevention information impact cancer prevention intentions and attitudes among a national sample of geographically rural u.s. adults? this study will contribute to knowledge of what messages and graphics promote understanding of cancer risk and promote screening with the potential to promote behaviors that reduce cancer risk.

the study occurred in two phases. phase one was a qualitative aim that collected feedback from participants in iterative cycles of focus groups and individual think-aloud interviews. phase one feedback was analyzed and applied to develop a tailored, web-based prototype that addressed participant desires for an intervention to address colorectal cancer prevention and nutrition risk education. the prototype was a brief conversation delivered by an interactive virtual health assistant (virtual character with audio and visual elements that mimic a conversation with a human).

Eligibility criteria:
inclusion criteria: * eligible adults will be between 45 -73 years old, * proficient in english and * geographically residing in rural areas (based on zip code) * identify as black or white racial identity exclusion: * completed a colonoscopy in the past 10 years * completed a sigmoidoscopy in the past 5 years * completed a home stool test in the past 12 months

Keywords: nutrition
safety and efficacy study of sunitinib malate in chinese patients with imatinib resistant or intolerant malignant gastrointestinal stromal tumor

Conditions: Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors

Summary: to investigate safety and efficacy of single agent sunitinib malate in chinese patients with imatinib resistant or intolerant malignant gastrointestinal stromal tumor.


Eligibility criteria:
inclusion criteria: * histologically-proven diagnosis of malignant gist (gastrointestinal stromal tumors). * evidence of unidimensionally measurable disease * failure of prior treatment with imatinib or intolerant to imatinib * male or female, 18 years of age or older. * ecog (eastern cooperative oncology group) performance status 0 or 1. * resolution of all acute toxic effects * adequate organ function. exclusion criteria: * anticancer treatment after last dose of imatinib * major surgery within 4 weeks or radiation therapy within 2 weeks. * grade 3 hemorrhage within 4 weeks prior to starting the study treatment. * diagnosis of second malignancy within the last 5 years. * history of brain disease. * cardiac disease within 12 months. * thyroid function abnormality. * ongoing cardiac dysrhythmias. * uncontrolled hypertension. * ongoing treatment with anticoagulant and cyp3a4 inhibitors and inducers. * hiv or aids related illness. * pregnancy or breastfeeding.

Keywords: sunitinib phase iv gastrointestinal stomal tumor imatinib resistant or intolerant chinese
comparison of analgesic effects of tap block and rsb in ralps

Conditions: Postoperative Pain

Summary: in this research, we aim to compare the postoperative analgesic efficacy of these two peripheral blocks in patients undergoing ralp who have received preoperative tap block and rsb block.

"robotic-assisted laparoscopic prostatectomy (ralp) is a minimally invasive and superior technique that provides better visualization and maneuverability compared to open and laparoscopic surgical techniques. previous studies have shown that ralp offers better postoperative oncological and physiological outcomes compared to open and laparoscopic techniques. however, ralp patients still experience pain lasting for several days postoperatively, which requires the use of analgesics such as opioids. this pain is associated with port site incisions, dissection of the prostate and surrounding tissues, bladder spasms, and transurethral catheter irritation. for this purpose, previous studies have utilized central and peripheral methods to reduce postoperative pain. previous studies have demonstrated the analgesic benefits of tap block and rectus sheath block in robotic-assisted radical prostatectomies. however, the number of studies in this area is limited. in this research, we aim to compare the postoperative analgesic efficacy of these two peripheral blocks in patients undergoing ralp who have received preoperative tap block and rsb block.

Eligibility criteria:
inclusion criteria: * patients aged 18-79 who underwent robotic radical prostatectomy * patients have asa (american society of anesthesiologists) physical status score of 1-3. exclusion criteria: * patients with an allergy to local anesthetic agents * a platelet count below 100,000 * inr value above 2

Keywords: transversus abdominis plane block rectus sheath block robot-assisted laparoscopic prostatectomy
bladder flap versus omission of flap during cesarean section of primiparous women

Conditions: Cesarean Section

Summary: cesarean section is the most common surgical procedure performed on women. over the years minor variations of each surgical step have been introduced, and cesarean sections are not standardized and many different techniques are employed during surgery. creation of a bladder flap has been an integral surgical step of the cesarean section for many years. the role of the bladder flap and its usefulness in cesarean section is not known well. further, in some cases the bladder flap is omitted during cesarean section. the aim of the current study is to compare operating time and postoperative urinary symptoms in cesarean sections using either bladder flap or omission of flap.

cesarean section is the most common surgical procedure performed on women. the main aspects of the surgical approach to low-transverse cesarean delivery have not changed much since1926. over the years minor variations of each surgical step have been introduced, and cesarean sections are not standardized and many different techniques are employed during surgery. creation of a bladder flap has been an integral surgical step of the cesarean section for many years. the evidence on the role of the bladder flap and its usefulness in cesarean section is very limited. in emergent cesarean sections where rapid delivery is the main goal, the bladder flap is usually omitted. literature about the usefulness of a bladder flap is limited and more randomized studies are needed. most of the study outcomes were focusing operating time however, the investigator in the current study additional focused on postoperative urinary symptoms and dynamics. the aim of the current study is to compare operating time and postoperative urinary symptoms in cesarean sections using either bladder flap or omission of flap.

Eligibility criteria:
inclusion criteria: * primiparous women \>37 weeks without high-risk pregnancy exclusion criteria: * presence of microbiologically confirmed urinary tract infection before delivery, twin pregnancies, cervical dilatation at admission ≥4 cm, estimated fetal weight\>4000 gr, history of previous abdominal surgery

Keywords: cesarean section operating time bladder urinary retention