Kornimate/medical-research-clean huggingface dataset:
perceptions of the annual review of competence progression (arcp) in surgical training in the uk and ireland

Conditions: Education, Medical

Summary: a prospective cross sectional questionnaire study was conducted to evaluate surgical trainees' experiences of the arcp process in order to identify areas for improvement.

background: surgical trainees in the uk and ireland undergo rigorous formative and summative assessments throughout each placement and appraisal at an annual review of competence progression (arcp). the arcp evaluates performance during each training year and determines progression to the next year of training. it is critical that the arcp is a robust and fair process. the association of surgeons in training (asit) sought to evaluate surgical trainees' experiences of the arcp process in order to identify areas for improvement. methods: a prospective cross-sectional questionnaire study was conducted an electronic survey was developed and distributed electronically to the trainee membership of asit in the uk and republic of ireland. a 57 point survey examined the specifics of one arcp cycle as well as attitudes to the process in general. quantitative analysis was performed, along with thematic analysis on the free-text comments.

Eligibility criteria:
inclusion criteria: * must be a trainee member of asit * all grades, deaneries, including less than full-time/academic trainees are eligible for inclusion exclusion criteria: • student members are excluded

Keywords: arcp surgical training assessment qualitative
the effects of the hopeful outdoor parkinson exercise (hope) program on improving balance performance in parkinsonian non-fallers and single fallers

Conditions: Parkinson's Disease

Summary: to determine whether the 8-week hopeful outdoor parkinson's exercise (hope) program would be effective in improving balance performance, physical functions, gait parameter, balance confidence, health-related quality-of-life, disease-specific motor performance and fall-related outcomes in parkinson's disease (pd) non-fallers and single fallers.

previous studies demonstrated that multi-modal balance training program was effective in improving balance performance in people with pd. however they did not include all the balance domains and outdoor fall-prone activities have been overlooked. we designed a task- and context-specific balance training program based on the framework of the balance evaluation systems test (bestest) to target all six balance domains including biomechanical constraints, stability limits and verticality, anticipatory postural adjustments, reactive postural responses, sensori-motor integration and dynamic gait control.

Eligibility criteria:
inclusion criteria: * diagnosed with pd by a neurologist (fahn and elton, 1987); * aged 30 to 85 years; * at modified hoehn and yahr (h\&y) stage 1.5 to 3 (hoehn and yahr ,1967; goetz et al., 2004); * able and willing to give written consent for participation in the study; * living at home in the community; * able to walk independently for 30 metres with or without an assistive device. exclusion criteria: * any neurological conditions other than pd; * significant musculoskeletal or cardiopulmonary diseases; * other disorders that may affect balance or locomotion; * taken any structured behavioral or exercise programs in the past 3 months * or they are receiving regular physical rehabilitation at present; * unstable condition on anti-parkinsonian medications; * surgical interventions for pd; * communication or cognitive deficits with mini-mental state examination, (mmse) \<24/30 (folstein et al., 1975); * a history of more than two falls in the previous 12 months.

Keywords: randomised controlled trial, postural balance, rehabilitation, exercise therapy, accidental falls
different types of manual therapy techniques in patients with chronic neck pain

Conditions: Neck Pain

Summary: the purpose of this study was to investigate the comparative effectiveness of high velocity and low amplitude (hvla)vs mobilization (mob) vs mobilization with movement technique (mwmt) in sample of patients with chronic neck pain (cnp). secondly to evaluate the immediate effects in range of motion and pain thresholds, and the interaction between psychological factors and the outcomes of these three types of manual therapy. the hypothesis is that all manual therapies techniques will produce similar effects.

the randomized controlled trial included patients with mechanically reproducible cnp, ≥ age 18-years who are randomized into three groups of treatment. the main outcome measures were the visual analogue scale (vas), and, with secondary measures of neck disability index (ndi), global rating of change (groc), cervical range of motion (crom), pressure pain threshold (ppt), state trait anxiety inventory (stai-t), beck depression inventory (bdi-ii), tampa scale for kinesiophobia, pain catastrophizing scale (pcs).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic neck pain exclusion criteria: * neck pain is associated with whiplash injuries. * resting blood pressure greater than 140/90 mmhg. * cervical radiculopathy. * cervical disc herniation. * fibromyalgia syndrome. * previous neck surgery.

Keywords: posterior neck pain cervical spine pain manual therapy
trial of covid-19 outpatient treatment in individuals with risk factors for aggravation

Conditions: Corona Virus Infection; Sars-CoV2

Summary: in adults with covid-19 without criteria for hospitalization or oxygen therapy but with risk factors for aggravation, early treatment may avoid hospitalization, indication for oxygen therapy or death. no treatment is currently validated for this indication.

coverage france is multicenter, randomized, controlled clinical trial with for each drug : * a safety study pilot phase. * an efficacy study phase. the data collected during the pilot phase, combined with new external data that emerged during the period, will be used to position treatments for the efficacy phase. * pilot phase will evaluate the tolerance of experimental treatments for drugs given for the first time ("first in home-based care") in ambulatory individuals with covid-19 with aggravating risk factors. * efficacy phase: to estimate the effectiveness of experimental ambulatory treatments, compared to vitamin supplementation, in reducing the risk of hospitalization, oxygen therapy indication or death in ambulatory individuals with covid-19 with aggravating risk factors. the trial is a national platform with the vocation to open as many centers as possible, subject to criteria set by the scientific advisory board.

Eligibility criteria:
inclusion criteria: * clinical picture suggestive of covid-19 dated 7 days or less. * positivity of a test proving an acute sars-cov-2 infection, according to current recommendations. * absence of criteria for hospitalization or oxygen therapy according to current recommendations. * age : * greater than or equal to 60 years of age without any risk factor * or between 50 and 59 years of age and the presence of at least one of the following risk factors : * arterial hypertension under treatment (all stages) * obesity (bmi ≥30 kg/m2) * diabetes under treatment (all types) * ischemic heart disease (all stages) * heart failure (all stages) * stroke history * chronic obstructive pulmonary disease (all stages) * stage 3 chronic renal failure (30 ≤ estimated gfr \< 60 ml/min/1.73 m²) * malignancies (solid tumours or blood malignancies) that are progressive or were diagnosed less than 5 years ago. * immunodeficiency * of therapeutic origin (solid organ transplant or hematopoietic stem cell transplant, cancer chemotherapy, immunosuppressive therapy, corticosteroids \> 15 mg/d of prednisone equivalent taken for at least 2 months); * hiv infection with cd4\<200/mm3. * valid, ambulatory person, fully able to understand the issues of the trial * beneficiary of a social security scheme * signed informed consent exclusion criteria: * asymptomatic person * inability to make a decision to participate (dementia, person under legal protection, curatorship or guardianship) * ongoing illness or chronic treatment contraindicated by taking one of the trial drugs.

Keywords: corona virus sars-cov2 telmisartan ciclesonide interferon β-1b
telephone-based support programs for people with epilepsy

Conditions: Epilepsy

Summary: this is a two-arm randomized controlled trial to compare telephone-based depression self-management (uplift) to telephone-based support groups (boost). a sample of 120 english- and spanish-speaking people with epilepsy (pwe) with elevated depressive symptoms will be enrolled. both interventions are 8-week programs delivered in one-hour weekly sessions to groups of about 6 participants. changes in depressive symptoms, quality of life and seizures will be assessed over 12 months. the trial will also examine mediators and moderators of treatment effects.

the objectives of the trial are: 1. to test effects of uplift versus boost on changes in depressive symptoms (primary outcome) in pwe over 12 months. 2. to test effects of uplift versus boost on changes in quality of life and seizures (secondary outcomes) in pwe over 12 months. 3. to test whether intervention effects are mediated by increases in mindfulness and decreases in rumination. 4. to test whether intervention effects are moderated by participant characteristics and facilitator characteristics.

Eligibility criteria:
inclusion criteria: * adult (≥18 years of age); * diagnosed with epilepsy for at least one year; * fluent in english or spanish; * elevated depressive symptoms (phq-9 score ≥10); * willing to participate in audiotaped group telephone sessions exclusion criteria: * severe depressive symptoms (phq-9 ≥20); * active suicidal ideation (phq-9 item #9 ≥1 or otherwise reported during screening); * active psychotic disorder (psychiatric diagnosis or antipsychotic medications in the ehr); * significant cognitive impairment (indicated in ehr or evident during screening)

Keywords: epilepsy depression seizures quality of life mindfulness telehealth
post-operative dental pain study comparing analgesic efficacy

Conditions: Post-surgical Dental Pain

Summary: glaxosmithkline will be conducting this trial to compare analgesics efficacy of paracetamol 1000mg vs 500mg . the post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol. each subject will be enrolled in the study for up to six weeks. the duration of the entire study will be approximately 16 weeks. each subject will have to come to the clinic for three visits (screening, treatment and follow up visits).


Eligibility criteria:
inclusion criteria: * subjects aged 18-45 years with moderate-to-severe dental pain assessed by verbal rating scale (vrs) and confirmed by a score of at least 50 mm out of 100 mm using a visual analogue scale (vas) following surgical removal of third molars, of which at least one has to be a mandibular partially bony or full bony impaction.

Keywords: paracetamol dental pain post-surgical dental pain
effectiveness of the universal prevention program super skills for life in schools

Conditions: Social Skills; Perfectionism; Self Esteem; Positive Affect; Negative Affect; Emotion Regulation; Depressive Symptoms; Anxiety Symptoms; Mood Disorders; Emotional Intelligence

Summary: this study aims to evaluate the effectiveness of a 12-session cognitive-behavioral transdiagnostic protocol for spanish children aged 8 to 12 within an educational context, super skills for life. the program, designed to enhance emotional management and social interaction skills, will be delivered in a group format and supplemented with multimedia materials. the study will compare outcomes between an intervention group and a wait-list control group.

a 2 x 4 factorial design will be employed, with the intervention condition (intervention or waiting list) as the intergroup factor and the evaluation phase (pretest, posttest, 6-month follow-up, and 12-month follow-up) as the intragroup factor. both parents and children will complete the same assessments at baseline, post-treatment, and follow-up stages. the researchers will analyze the changes in emotional and social variables from pre- to post-assessment in children who participate in the program.

Eligibility criteria:
inclusion criteria: * children aged 8 to 12 years. * be spanish-speaking. * accepting informed consent to participate in the study. exclusion criteria: * intellectual disability, behavioral symptoms or autistic spectrum symptoms whose severity prevented the continuation of treatment. * current psychological or pharmacological treatment for anxiety and/or depression. * not accepting or revoking informed consent to participate in the study.

Keywords: social skills emotional skills prevention universal program program evaluation transdiagnostic protocol cognitive-behavioral protocol childhood children school educational context group format
the effects of an intensive lifestyle modification program on carotid artery intima-media thickness

Conditions: a Myocardial Infarction; Coronary Artery Bypass Graft Surgery Percutaneous Transluminal Coronary Angioplasty Stent Placement

Summary: the objective of this study is to evaluate the effect of the ornish program on cardiovascular disease as measured by the imt of the common carotid artery, and to compare this effect to outcomes from patients participating in traditional cardiac rehabilitation.


Eligibility criteria:
inclusion criteria: patients will be accepted into the study if they demonstrate one or more of the following within the previous 12 months: a myocardial infarction, coronary artery bypass graft surgery, or percutaneous transluminal coronary angioplasty, stent placement, or rotoblator procedures. patients will also accepted if they have stable angina as determined by the rose questionnaire or pacemaker associated with one or more of the previously mentioned diagnoses. for the purposes of this study, myocardial infarction is defined as the presence of at least two of the following three criteria: continuous chest pain lasting at least 30 minutes; electrocardiogram changes expressing an evolving myocardial infarction (st segment elevation or depression, evolving q waves, or symmetric inversion of t waves); or elevated cardiac enzyme levels (at least twice the i levels). exclusion criteria: -
study to determine a preference for fluzone vaccine given intradermally (id) and intramuscularly (im) in healthy adults

Conditions: Influenza

Summary: to describe any degree of preference for the route of administration of fluzone influenza vaccine, id versus im, in healthy adult subjects 18-49 years of age. to collect safety data, injection site reactions, and systemic reactions, through day 7 post-vaccination; saes through day 28 post-vaccination

the purpose of this clinical trial is to determine, in a relatively small sample of persons 18-49 years of age, if there is a preference trend for a particular route of administration, id vs im, when receiving a seasonal influenza vaccine. uptake of influenza vaccine is disappointingly low in this age group, and there is the perception that aversion to im injection plays a role in vaccination avoidance. the bd micro-injection system to be used in this study may offer a more acceptable alternative to the standard im injection for influenza immunization and thereby promote wider acceptance of influenza vaccination.

Eligibility criteria:
inclusion criteria: * healthy male or female subject (can have underlying medical condition, as long as they are stable), greater than or equal to 18 to \< 50 years of age on the day of inclusion. * informed consent form signed. * able to attend both scheduled visits and to comply with all trial procedures. * for a woman of child-bearing potential, avoid becoming pregnant (use of an effective method of contraception or abstinence) for at least 4 weeks prior to vaccination, until at least 4 weeks after vaccination. exclusion criteria: * subject currently breast-feeding. * participation in another investigational clinical trial in the 4 weeks preceding and during the trial period. * hypersensitivity to egg proteins, chicken proteins, or to any of the vaccine components, or history of a life-threatening reaction to the trial vaccine or a vaccine containing any of the same substances. * thrombocytopenia or bleeding disorder contraindicating im vaccination. * any other condition which in the opinion of the investigator would pose a health risk to the subject or interfere with the evaluation of the vaccine. * personal history of guillain-barre syndrome. * current use of alcohol or recreational drugs that in the opinion of the investigator might interfere with the subject's ability to comply with trial procedures. * febrile illness (oral temperature greater than or equal to 99.5 degrees f) on day of inclusion (temporary deferral). * influenza vaccination received this season (2007-2008).

Keywords: influenza influenza virus
investigation of the clinical safety and efficacy of long-term treatment with fycompa tablets in adolescence epilepsy patients with partial-onset seizures (with or without secondary generalized seizures) or primary generalized tonic-clonic seizures

Conditions: Partial Seizures (With or Without Secondary Generalized Seizures); Primary Generalized Tonic-clonic Seizures

Summary: the objective of this study is to identify the following in adolescent epilepsy participants with partial-onset seizures (with or without secondary generalized seizures) or primary generalized tonic-clonic seizures who receive long-term treatment with fycompa: 1. unknown adverse drug reactions (adrs); 2. occurrence of adrs; 3. factors that are likely to affect safety and efficacy; 4. occurrence of dizziness, balance disorders, ataxia, muscle relaxation-related adverse events, and falls as priority investigation items; 5. occurrence of psychiatric adverse events as priority investigation items (eg, aggression).


Eligibility criteria:
inclusion criteria: * epilepsy participants from 12 to 17 years of age with: * partial seizures (with or without secondary generalized seizures) * primary generalized tonic-clonic seizures exclusion criteria: * participants previously treated with fycompa

Keywords: adolescent epilepsy participants partial seizures primary generalized tonic-clonic seizures
proportional assist ventilation (pav) in early stage of critically ill patients

Conditions: Respiratory Failure; Mechanical Ventilation

Summary: to evaluate the effectiveness of high assistance proportional assist ventilation (pav+) (objective 80% gain) as main ventilatory support in early stage of critically ill patients in comparison with standard volume-assist control ventilation (acv).

the goal of this proposal is to apply pav+ as routine ventilatory mode in the early stage of critically ill patients, taking advantages of spontaneous breathing and better patient-ventilator interaction. the standard treatment in patients with acute respiratory failure is mechanical ventilation in control-mode for the first days of acute illness. this procedure is usually associated with patient-ventilator dyssynchrony, higher needs of sedation and/or relaxation, muscle atrophy, etc. pav + is a new ventilatory mode that applies pressure in proportion to spontaneous patient inspiratory effort allowing better adaptation to changes in internal homeostasis. up to now, several reports compare pav with assisted modes as a feasible alternative only in the weaning phase. however, pav is able to unload patient effort in different levels, suggesting that high-assistance pav (about 80%) could be comparable with assist-control modes in terms of respiratory muscles unload. whether pav is as effective as traditional acv in terms of ventilation muscle unload in the acute phase of illness has not been established and we aim to address this question. we plan to prospectively enroll patients on mechanical ventilation early at icu admission, and to ventilate them randomly under acv (volume-assist control ventilation) or pav+ (beginning with 80% if possible). we will evaluate length of mechanical ventilation, sedation requirements and respiratory-hemodynamic variables from the very beginning and until attending clinicians decide that patients are ready to be weaned.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * anticipated mv \> 24 hours * availability of informed consent from patient or next of kin * ventilation parameters measured under pav+ 80% gain: pao2/fio2 \>100 rpav \ 30 ml/cm h2o wobtot \<1.5 j/l ve \<18 l/min exclusion criteria: * patients on moribund state or with life-sustaining therapy withholding decision. * patients with unstable respiratory/hemodynamic state, pao2/fio2 \ 15 microg/kg/min or epinephrine \>0.1 microg/kg/min. * pregnancy. * air leak. * patients needing deep sedation or muscle paralysis * patients needing hyperventilation (brain trauma). * patients with severe muscle weakness. * recruitment maneuvers or prone position.

Keywords: proportional assist ventilation plus acute respiratory failure mechanical ventilation
adapting the hope online support intervention to increase uptake of medications for opioid use disorder

Conditions: Opioid-use Disorder

Summary: in a randomized controlled trial, with 3, 6-month and 1-year follow-up, this application aims to explore whether and how the hope intervention can be adapted to increase moud uptake among oud patients, assess the effectiveness of using hope to increase moud requests, and analyze online community data to improve future intervention implementation and sustainability.

the proposed study is a low-risk, randomized control trial to assess the efficacy of the hope (harnessing online peer education) intervention, an evidenced-based peer-led social media/online community intervention (e.g., facebook groups), to increase self-reported requests for medications for opioid use disorder (moud) among patients with moderate to severe opioid use disorder (oud). participants will be recruited using a variety of recruitment methods including social media sites (e.g., facebook), referral by physicians, medical records, research study websites (e.g., ucimc clinical trials website), and study flyers disseminated at various venues, including clinics, group meetings, and shelters. once enrolled, participants will be randomly assigned to an intervention or control group. intervention group participants will be invited to join a private and hidden (unable to be viewed or searched for by others) group on facebook, with approximately 6 peer leaders included in the group. those in the control group will be invited into a facebook group, but without peer leaders. the intervention will last 12 weeks. study measures will be collected at the beginning of the study (baseline), after the completion of the intervention (3 months), with follow up surveys at 6 and 12 months after the study.

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years of age; 2. resident of ca, nv, az, or, wa; 3. english speakers only; 4. has moderate to severe oud; 5. is not currently prescribed moud; 6. reports using social media at least 2x per week; 7. has, or is willing to create a facebook/social media account and accept a friend request and group invite from our study social media page exclusion criteria 1. anyone who does not fit inclusion criteria above 2. was a participant in phase i of the study 3. participants with active, unstable opioid, alcohol, sedative, or other substance use and/or unstable medical or psychiatric conditions as assessed by the study questionnaires will be reviewed by the study physician consultants and will be excluded and referred for acute care including detoxification, if needed.

Keywords: online community