Kornimate/medical-research-clean huggingface dataset:
radiotherapy assessments during intervention and treatment (radiant)

Conditions: Radiation Therapy; Cancer; Cancer of Anus; Cancer of Bladder; Cancer of Cervix; Cancer of Colon; Cancer of Rectum; Cancer of Esophagus; Cancer of Gallbladder; Cancer of Liver; Cancer of Ovary; Cancer of Pancreas; Cancer of Prostate; Cancer of Kidney and Renal Pelvis; Cancer of Stomach; Cancer of Testis; Cancer of Uterus; Cancer of Uterus and Cervix; Cancer of Kidney

Summary: collect blood samples and associated clinical data prior to, during, and post radiation treatment.

in order to further refine and independently validate the performance of dxterity's test developed during the previous pilot study, the study will collect pre-, during, and post-irradiation blood samples and associated clinical and self-reported information from up to five hundred (500) subjects for analysis. patients with a diagnosis of primary gastrointestinal (gi), genitourinary (gu), or gynecological (gyn) cancer requiring radiation treatment to the primary disease site will be included in the study. combining chemotherapy is allowed. blood samples for this study will be collected from cancer patients scheduled to undergo radiation therapy prior to and either during or after treatment. approximately 150μl of blood per time point will be obtained via fingerstick remotely, from the participant's home or doctor's office; participation in this study will not affect any aspect of patient treatment. samples will be collected using dxterity's proprietary dxcollect® mcd fingerstick kit (mcd).

Eligibility criteria:
inclusion criteria: 1. male and female patients age 18 or older 2. have a permanent address in the united states for the duration of the study 3. diagnosed with a primary gastrointestinal (gi), genitourinary (gu), or gynecological (gyn) cancer 4. planned radiation therapy to the abdominal/pelvic area as part of clinical care 5. able to provide informed consent exclusion criteria: 1. receipt of radiation within three (3) months to abdominal/pelvic area prior to scheduled start of radiation treatment

Keywords: anal cancer bladder cervical colorectal esophageal gallbladder liver ovarian pancreas pancreatic prostate rectal renal kidney stomach testicular uterine cancer radiation therapy radiation treatment
rescue treatment pattern, drug resistance recurrence, and direct medical costs associated with chinese patients with chronic hepatitis b and drug resistance to nucleot(s)ide analogue therapy

Conditions: Hepatitis B

Summary: the purpose of this study is to describe current rescue treatment pattern for nucleot(s)ide analogue (na) resistance and assess the real-world treatment outcomes and health resources utilization of rescue treatments for drug resistance in a clinical cohort of chinese patients with chronic hepatitis b (chb).


Eligibility criteria:
inclusion criteria: * chb patient with drug resistance confirmed by hepatitis b virus (hbv) gene mutation and virological breakthrough * patient receiving rescue treatments for drug resistance to previous na therapy for chb * patient who was regularly followed at least every 6 months for drug resistance at the tertiary liver clinic of sxh exclusion criteria: * patient with a diagnosis of hepatocellular carcinoma, decompensated cirrhosis, and/or liver transplantation prior to the development of drug resistance to na therapy for chb * patient with co-infection with hepatitis c virus, hepatitis d virus, and/or human immunodeficiency virus * patient with life expectancy less than 6 months after the date of the first laboratory test indicating drug resistance other protocol defined inclusion/exclusion criteria could apply
finger hardness measure in scleroderma

Conditions: Scleroderma

Summary: thirty subjects with systemic sclerosis and 30 age and sex matched controls without any known condition that should cause increased skin hardness in the fingers with undergo examination by manual palpation and durometer measured hardness of their digital tuft skin by 2 observers on 2 separate occasions. there will be 1 hour between individual observer's scorings. observers will be blinded from the observer's scores and from their previous scores. results will be tabulated and compared for manual scores versus durometer measurements, intra-observer scores by both methods and inter-observer scores by both methods.

it is pretty straightforward. we will measure and record the hardness of the digital tufts on ten digits by palpation and the hardness in the same area by using a durometer. we will repeat this one hour later. scores will be compared as a measure of how consistent and precise they are.

Eligibility criteria:
inclusion criteria: * scleroderm * rheumatologic condition not effecting the skin tightness

Keywords: scleroderma skin tightness durometer
does cesarean section scar defect (niche) affect implantation rate?

Conditions: Infertility; Complications; Cesarean Section

Summary: cesarean scar defects (csds), i.e. deficient uterine scars following a cesarean section, involve discontinuity at the site of a previous cesarean section scar. these anatomical defects have been reported to be associated with postmenstrual spotting, chronic pelvic pain and infertility. few case series have suggested improved fertility (most probably by improving implantation of embryos) the aim of this study is to prospectively record embryonal implantation rate during ivf in patients with csds, and to evaluate the effect of hysteroscopic repair of csds on fetal implantation during ivf.

150 patients undergoing ivf after cesarean section will be recruited. demographic, clinical and treatment data will be collected. ultrasound and hysteroscopic evaluation of the csd will be performed. ivf treatment will be provided. in case of failure of ivf treatment, patients will be randomized to hysteroscopic repair of csd versus second ivf treatment

Eligibility criteria:
inclusion criteria: * patients undergoing ivf after cesarean section exclusion criteria: * patients who underwent csd repair * patients with low ovarian reserve * patients with hydrosalpinges, endometriosis, adenomyosis, submucous fibroids or polyps

Keywords: cesarean section defect implantation ivf
engagement in physical activities and sports in adolescents with diaphragmatic hernia

Conditions: Congenital Diaphragmatic Hernia

Summary: the objective is to understand how a population of adolescents - who have undergone diaphragm surgery within their first month of life (i.e. subjects who have been carriers of a rare impacting disease such as congenital diaphragmatic hernia (cdh)) - engages in physical and sports activities and what can be the hindering factors as well as the factors facilitating these practices. based on self-questionnaires and semi-structured interviews, this research is a qualitative research in the field of human and social sciences. the qualitative survey will make it possible to report on the experience of the disease of children and parents; in parallel, a complete medical evaluation of the subjects (clinical and para-clinical) will be carried out. the analysis of the verbatim of the self-questionnaires and interviews with regard to the real physical capacities of the subjects, will be discussed.


Eligibility criteria:
inclusion criteria: * child/adolescent having undergone surgery for cdh in the first month of life, aged 12 to 18 years; absence of polypathology (i.e. diaphragmatic hernia not associated with another pathology); follow-up at the cdh reference centre, lille site * written consent from both parents allowing the collection of data from the child/adolescent * written consent from the parent(s) agreeing to participate in the study by answering the questionnaires and the individual interview, for themselves and for their child * possibility of accessing equipment to conduct a video-conference interview if necessary. exclusion criteria: * parents or child/adolescent not understanding french * parents under guardianship or child under legal protection

Keywords: cdh physical activity and sports childhood and adolescence environment sociological psychological clinical
turning performance in stroke

Conditions: Stroke

Summary: turning is a challenging task for stroke patient. previous studies showed that turning is one of the activities which resulting in falling frequently in stroke. however, the assessment tool of turning performance is still lack of reliability and validity. furthermore, the main factors which affected turning ability in stroke are not approved yet.


Eligibility criteria:
inclusion criteria: * 6 months after first stroke. * able to independently walk 7 meter at least without any device * mmse score ≧ 24 exclusion criteria: * unstable medical conditions (such as deep vein thrombosis) * any disease which has known affecting walk(heart failure, diabetes)
extraction space consumption and overjet reduction after maxillary anterior enmasse retraction in orthodontics

Conditions: Extraction Space Consumption and Overjet Reduction

Summary: extraction space consumption and overjet reduction after maxillary anterior enmasse retraction in orthodontics

the relation between extraction space consumption and overjet reduction during maxillary anterior en-masse retraction by two levels of force application

Eligibility criteria:
inclusion criteria: * 1. young adult male and female patients (age range from 18 to 25 years) with maxillary dental protrusion. 2. patients with angle class i or class ii division i malocclusion with maxillary anterior teeth protrusion and proclination. 3. skeletal class i. 4. healthy compliant and motivated patient. 5. no missing of any tooth except wisdom teeth. 6. good oral hygiene. exclusion criteria: * 1. previous orthodontic treatments. 2. any systemic or bone diseases. 3. pregnant and lactating patient. 4. smoking history. 5. presence of periodontal diseases. 6. previous maxillary anterior surgery. 7. gingival overgrowth.
clinimetric properties of performance-based measures of physical function in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: a copd (chronic obstructive pulmonary disease), is a group of progressive lung diseases. copd is a preventable and treatable respiratory disorder largely caused by smoking and long term exposure to chemical irritants. this study aims to provide essential insights into the reliability, validity, responsiveness and interpretability of such tests, enabling healthcare professionals to make informed decisions about patient recovery progress and the optimization of rehabilitation protocols.

a copd (chronic obstructive pulmonary disease), is a group of progressive lung diseases, a preventable and treatable respiratory disorder largely caused by smoking and long term exposure to chemical irritants. copd affects the respiratory system and is progressive, which can result in a number of difficulties or impairments. ) effect on daily activities, work limitations, fatigue muscle weakness, breathlessness and reduced exercise capacity, and impaired quality of life. pulmonary rehabilitation is a comprehensive course that helps people with chronic respiratory illnesses, such as copd, improve their overall health and quality of life. clinimetric properties of four distinct tools designed for assessing performance-based physical functional outcomes following copd patients surgery. 6 minute walk test (6mwt), 2 minute walk test (2mwt), and timed up and go (tug), 30sec sit to stand test (30sec sts) will be assessed to determine any changes in their functionality test.

Eligibility criteria:
inclusion criteria: * diagnosed cases of copd (fev1/fvc \< 0.70). * both genders * clinically stable * age 40-65 years exclusion criteria: * disease exacerbation in last 4 weeks * co-existing respiratory or any other condition * inability to perform tests due to cognitive or any physical limitations

Keywords: clinimetric properties, copd, performance-based measures
clinical evaluation of the safety and efficacy of yung sheng 55 % color contact lens

Conditions: Myopia

Summary: this was a single group, open-label clinical study to assess the safety and efficacy of yung sheng 55% color contact lens for vision correction.


Eligibility criteria:
inclusion criteria: 1. the subject must sign the informed consent form. 2. the subject must be at least 20 years of age as of the date of evaluation for the study. 3. the subject must have a spherical prescription range between 0 to -12.00 diopters in each eye. 4. the subject must have manifest refraction snellen visual acuities (va) less than 0.8 in each naked eye. 5. the subject must have normal eyes, except ametropia. 6. the subject must appear able and willing to adhere to the instructions set forth in this clinical protocol. 7. the subject must appear able and willing to fill the daily card. exclusion criteria: 1. the subjects who need to use ophthalmic medicine for therapy. 2. the subjects who have ocular or systemic allergies or disease that may interfere with contact lens wear. 3. the subjects who have any history of ocular surgery/injury within 8 weeks prior to enrollment. 4. the subjects who have clinically significant tear secretion abnormal. 5. the subjects who enrolled in another contact lens clinical trial within 30 days prior to enrolment.
foxbionet pilot project: save (synuclein assay validation effort)

Conditions: Parkinson Disease

Summary: the overall objective of this study is to compare the performance of available oligomeric and phosphorylated a-synuclein assay in cerebrospinal fluid and blood.

specific aims to accomplish this objective are: 1. assess the reliability of oligomeric and phosphorylated a-synuclein concentration between two different oligomeric and three phosphorylated asynuclein assays. 2. assess the reliability of the oligomeric and phosphorylated a-synuclein concentrations between laboratories 3. assess the correlation of oligomeric and phosphorylated a-synuclein concentrations between cerebrospinal fluid and blood. 1.2. secondary objectives 1. to assess the ability of the network of pilot sites to efficiently conduct a study involving biosample collection for pd research. efficiency will be assessed using measures of the time taken to meet specific milestones within the study. 2. to assess the ability of the network to collect high quality biospecimens adhering to agreed-upon protocols. 3. to gauge the willingness of participants to participate in subsequent fox bionet studies

Eligibility criteria:
inclusion criteria: parkinson's disease subjects * patients must meet the mds criteria for parkinson's disease. * disease duration: any * male or female age 30 years or older at time of pd diagnosis. control subjects * male or female age 30 years or older at screening. exclusion criteria: parkinson's disease subjects * inability to provide informed consent * current treatment with anticoagulants (e.g., coumadin, heparin) that might preclude safe completion of the lumbar puncture. * condition that precludes the safe performance of routine lumbar puncture, such as prohibitive lumbar spinal disease, bleeding diathesis, or clinically significant coagulopathy or thrombocytopenia. * participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans. control subjects * inability to provide informed consent * current treatment with anticoagulants (e.g. coumadin, heparin) that might preclude safe completion of the lumbar puncture. * condition that precludes the safe performance of routine lumbar puncture, such as prohibitive lumbar spinal disease, bleeding diathesis, or clinically significant coagulopathy or thrombocytopenia. * participation in a blinded clinical trial of any kind or an unblinded trial of an investigational product that is not currently approved for use in humans. * the presence of rest tremor, bradykinesia or rigidity. * the presence of any other neurological sign that in the opinion of the site investigator raises suspicion for an atypical parkinsonian syndrome (e.g. supranuclear gaze palsy)

Keywords: parkinson's disease alpha-synuclein biomarker
control of major bleeding after trauma study

Conditions: Trauma; Hemorrhagic Shock

Summary: bleeding is the most avoidable cause of death in trauma patients. up to one-third of severely injured trauma patients are found to be coagulopathic and forty percent of the mortality following severe injury is due to uncontrollable hemorrhage in the setting of coagulopathy. it has been established that early administration of fresh frozen plasma decreases mortality following severe injury, replacing lost coagulation factors, improving the coagulopathy and restoring blood volume. this study will determine if giving plasma to severely injured trauma patients during ambulance transport versus after arrival to the hospital will help reduce hemorrhage, thus decreasing both total blood product administration and mortality.

study design: severely injured trauma patients with a systolic blood pressure (sbp) ≤ 70 or sbp ≤ 90 with a heart rate ≥ 108 bpm at the scene will be enrolled and randomized to receive either 2 units of frozen plasma thawed in the field or normal saline (the current standard of care), as the initial resuscitation fluid. after this initial resuscitation fluid, both groups will receive the same standard of care, including packed red blood cells, additional normal saline, or plasma as needed based on laboratory and clinical evidence of coagulopathy. blood samples and clinical information will be collected throughout the hospital stay up to 28 days after injury.

Eligibility criteria:
inclusion criteria: * age\>=18 years * acutely injured * sbp\ 108 beats per minute. exclusion criteria: * visibly or verbally reported pregnant women * known prisoners * unsalvageable injuries (defined as asystolic or cardiopulmonary resuscitation prior to randomization) * known objection to blood products * the patient has an opt-out bracelet or, necklace or wallet card * a family member present at the scene objects to the patient's enrollment in research.

Keywords: coagulopathy hemorrhagic shock plasma blood product transfusion
gentian violet treatment for hidradenitis suppurativa

Conditions: Hidradenitis Suppurativa

Summary: this is a survey study being conducted to describe how subjects with hidradenitis suppurativa (hs) respond to treatment with gentian violet. the study will rely primarily on qualitative survey responses and quantitative changes in skin appearance.

hidradenitis suppurativa (hs) is a chronic disease of the folliculopilosebaceous unit, often found in intertriginous areas of the body. the pain and impairment of hs leads patients to report a decreased quality of life, even in comparison to other debilitating cutaneous disease states. pharmalogic management of hs can vary from topical antibiotics or intralesional corticosteroids for mild cases to immunosuppressants and biologic agents in refractory cases. gentian violet is a topical antiseptic used to treat many cutaneous yeast infections. it also has a role in improving wound healing in sites of active ulceration. it is our hypothesis that gentian violet will help minimize skin trauma in sites of active hs to promote improved wound healing and quality of life.

Eligibility criteria:
inclusion criteria: * patients must have active hs, be willing to undergo one application of hs, and agree to follow-up in one month. exclusion criteria: * exclusion criteria include children, absent hs lesions at the time of clinic, and cognitive/physical impairments that would make them unable to assess quality of life factors of the survey.

Keywords: hs gentian violet nonsurgical treatment
the feasibility of the painreportit guided relaxation intervention-outpatient

Conditions: Sickle Cell Disease; Stress; Pain

Summary: our goal is to improve the self-management of pain and stress in adult outpatients with sickle cell disease (scd) by determining the feasibility of a self-managed guided relaxation (gr) stress reduction intervention using a tablet-based mobile device. currently, opioid analgesics are primarily used to treat scd pain while self-managed behavioral modalities such as gr, are rarely used. little is known about the effects or mechanisms of gr on pain and stress, in adults with scd. emerging evidence from the hypothalamic pituitary adrenal (hpa) axis theory offer insights for understanding the mechanisms. adding gr as a supplement to analgesic therapies will address the paucity of self-management strategies for controlling pain in scd. gr is a simple and cost-effective non-drug intervention that could reduce pain and stress in outpatients with scd. gr is an intervention where outpatients with scd are directed to listen to and view audio-visual recordings while they visualize themselves being immersed in that scene.

the investigator will recruit adult outpatients with sickle cell disease (scd) from the university of florida health hematology clinics and conduct study visits in a research room located at the college of nursing. the investigator will stratify participants on worst pain intensity (\ 5) and randomly assign 15 adults to attention control (stress/pain tracking; 12-min scd experience discussion) and 15 adults to experimental (stress/pain tracking; 12-min gr video clip) groups. the immediate intervention effects will be examined for pain (primary) and stress (secondary) outcomes. vital signs for determining relaxation responses (mediators) will be collected immediately before and after the 12-min interventions.

Eligibility criteria:
inclusion criteria: * has scd diagnosis; * reports pain 3 or greater in the previous 24 hours (0-10 scale) * receives care at the university of florida (uf) health/shands * speaks and reads english * 18 years of age or older * self-identifies as being of african or hispanic descent exclusion criteria: * legally blind * physically or cognitively unable to complete study measures