Kornimate/medical-research-clean huggingface dataset:
a trial of doxorubicin/cyclophosphamide (ac), docetaxel (d), and alternating ac and d for metastatic breast cancer

Conditions: Breast Cancer; Neoplasm Metastasis

Summary: to investigate the clinical benefits of docetaxel or alternating ac-docetaxel in comparison with standard ac for metastatic breast cancer

power to detect a 50% increase in median ttf at 0.025 one-sided alpha in ac vs. d and ac vs. ac-d. results: 441pts (146 in ac, 147 in d, 148 in ac-d) were randomized between 01/99 and 05/03. major grade 3-4 toxicities were neutropenia (26/45/46% for ac/d/ac-d), febrile neutropenia (3/4/6%), nausea/vomiting (3/3/4%). there was no toxic death. one grade 4 diarrhea in ac-d and 1 secondary leukemia (apl) in d were reported. response (cr/pr) rates were 30, 41, and 35% for ac, d, and ac-d respectively. median ttf (ac, d, and ac-d) are 6.4, 6.4, and 6.7 months (p =.255 for ac vs. d, p =.275 for ac vs. ac-d), and median overall survival are 22.4, 25.7, and 25.0 months (p=.092 for ac vs. d, p=.076 for ac vs. ac-d). the same difference was shown by the adjusted cox model. conclusions: no benefit was demonstrated in d and ac-d over ac in ttf, however, d and ac-d tended to be superior to ac in response rate and overall survival. survival benefit of front-line docetaxel should be re-evaluated by further long follow-up.

Eligibility criteria:
inclusion criteria: 1. hormonal therapy-resistant mbc 2. er (-), failure of hormonal therapy for mbc, or relapse within 6 months after adjuvant hormonal therapy 3. no anthracyclines for mbc and no prior taxanes 4. at least 6 months from the completion of adjuvant chemotherapy 5. measurable or evaluable lesions 6. age: 20 to 75 years 7. ps: 0-3 8. wbc \>= 4,000 /mm3 or anc \>=1,000 /mm3, platelet \>= 100,000 /mm3, sgot/sgpt \<= 1.5 x uln, t-bil \<= 1.5 mg/dl, cr \<= 1.5 mg/dl 9. normal ecg 10. written informed consent exclusion criteria: 1. pregnant 2. malignant pleural effusion, ascites, or pericardial effusion that requires emergent treatment 3. active infection 4. other cancer present within the last 5 years 5. previous stem cell transplantation 6. brain metastasis that requires emergent treatment 7. relapse within 6 months after completion anthracycline or during anthracycline 8. more than 250mg/m2 of anthracyclines 9. hypersensitivity of drug 10. interstitial pneumonitis or pulmonary fibrosis 11. positive hbs 12. antipsychotic medication 13. doctor's judgement

Keywords: metastatic breast cancer drug therapy doxorubicin docetaxel
spect-based prediction and evaluation of crt efficacy in chf

Conditions: Chronic Heart Failure

Summary: this study evaluates the state of the cardiac sympathetic activity and the severity of ventricular dyssynchrony in chronic heart failure patients and assesses the capabilities of radionuclide indication methods in determining the prognosis and evaluating the results of cardiac resynchronization therapy in chronic heart failure patients.

in heart failure, abnormal activation of cardiac sympathetic system has been shown to be of pathophysiological significance. however, the left ventricular (lv) dyssynchrony has a detrimental effect on lv systolic and diastolic functions in heart failure patients. the effects of lv dyssynchrony on cardiac sympathetic activity are not yet fully understood. dilated cardiomyopathy is a common cause of severe chronic heart failure. cardiac resynchronization therapy (crt) is a disease modifying device-driven treatment that can reduce morbidity and mortality in patients with heart failure. however, this type of treatment does not lead to the expected results in 25% to 30% of patients despite the successful implantation of a crt device. in addition, crt is associated with high cost and potential morbidity. therefore, the search for new highly informative criteria for selecting patients for this type of treatment remains a relevant task of modern medicine. it is expected that the results obtained will complement and expand current state of knowledge regarding the relationships between cardiac remodeling processes and the state of cardiac sympathetic activity. in addition, obtained data will allow to predict lv remodeling dynamics after the correction of contractile dysfunction of the heart.

Eligibility criteria:
inclusion criteria: * chronic heart failure nyha iii and iv class * lvef ≤ 35 % * qrs ≥ 150 ms on ecg * the presence of lbbb on ecg * sinus rhythm * optimal pharmacological treatment of heart failure exclusion criteria: * contraindications to spect due to hypersensitivity to radiopharmacuticals such as 2-methoxy-isobutyl-isonitrile-(99mtc) and (123)i-meta-iodobenzylguanidine or any of the excipients * pregnancy * breastfeeding * refusal to participate

Keywords: spect 123i-mibg chronic heart failure cardiac resynchronization therapy czt
effect of multi strain probiotic on ferritin levels in children with iron deficiency

Conditions: Iron Deficiency (ID)

Summary: the goal of this clinical trial is to learn about the effect of multi-strain probiotic (bacteria and yeast) on ferritin levels in children age 1 - 18 years old who had iron deficiency in 15 orphanages of makassar city. the main questions it aims to answer are: • are ferritin levels in iron deficiency children given iron standard therapy with multi-strain probiotics (bacteria and yeast) higher than those given iron standard therapy with placebo? researchers will compare iron standard therapy with multi-strain probiotics (bacteria and yeast) to a placebo to see if muti-strain probiotics works to treat iron deficiency in children. participant will : * take iron standard therapy with multi-strain probiotics (bacteria and yeast) or iron standard therapy with placebo every day for 30 days * ferritin levels were evaluated on day 31

the aim of this study was to assess the effect of multi-strain probiotic (bacteria and yeast) on ferritin levels in children with iron deficiency treatment. it is a randomized controlled trial (rct) conducted in 15 orphanages of makassar city in children aged 1 - 18 years. the study population was children aged 1 - 18 years who had iron deficiency. eligible children are randomized into two groups - an intervention group receiving standard iron therapy with multi-strain probiotics (bacteria and yeast) and a control group receiving standard therapy with placebo. the primary outcome is serum ferritin levels, measured at baseline and after 30 days of intervention. blood samples are collected to measure ferritin levels. the study aims to enroll 80 infants (40 per group) to detect a clinically meaningful difference in ferritin levels between groups. this trial will provide evidence on whether multi strain probiotic can increasing ferritin levels in children with iron deficiency treatment. the results may inform clinical practice regarding the use of probiotics multi strain as an adjunctive therapy for iron deficiency in children.

Eligibility criteria:
inclusion criteria: * children with iron deficiency * age 1 year - 18 years * the parent or person in charge of the foundation signed the informed consent that the child was willing to be included in the study. exclusion criteria: * iron deficiency children with infection, renal impairment and hepatic impairment were identified through interviews with caregivers and physical examination of the children. * children with immunocompromise (malignancy, malnutrition, hiv). * iron deficiency children who have received iron therapy and last consumed 3 months prior to the study. * iron deficiency children who were temporarily receiving iron therapy or iron supplementation.
effect of muscle stiffness on vertebral fractures in women over 60

Conditions: Osteoporosis in Post-menopausal Women; Vertebral Body Fractures; Balance, Postural

Summary: this study aims to assess the quality of lumbar and abdominal core muscles through elastography and evaluate its impact on vertebral fracture risk. this tudy's secondary objective is to investigate the relationship between muscle quality, as measured by elastography, and balance and quality of life. the fundamental questions that this study aims to answer are as follows: does the quality of lumbar and abdominal core muscles, as assessed by elastography, affect the risk of vertebral fractures? is there a relationship between muscle quality (as measured by elastography) and balance and quality of life in older adults?

osteoporosis, a systemic bone disease marked by reduced bone mass and deteriorating bone structure, increases fracture risk, especially in the spine. vertebral fractures, most common in the lower thoracic and upper lumbar regions, can impair motor function, limit daily activities, and raise disability and mortality risks. with aging, decreasing bone mineral density (bmd) and muscle quality contribute to structural changes like kyphosis and lordosis, further reducing balance and increasing fracture risk. while dexa remains the standard for bmd assessment, ultrasound (usg) and shear wave elastography (swe) offer non-invasive imaging for muscle quality without radiation exposure. despite muscle degeneration's impact on spinal stability, most osteoporosis studies focus on bones, with few examining muscles. recognizing this gap, our study uses elastography to assess lumbar and abdominal muscle quality and its impact on vertebral fracture risk, while also exploring the relationship between muscle quality, balance, and quality of life in older adults.

Eligibility criteria:
inclusion criteria: * female, aged ≥ 60 years exclusion criteria: * history of lumbar spine surgery * cancer * spinal infection * severe degenerative scoliosis * chronic kidney failure * liver cirrhosis * bilateral hip arthroplasty

Keywords: vertebral fractures osteoporosis abdominal muscles
a study of the activity of eculizumab for prevention of delayed graft function in deceased donor kidney transplant

Conditions: Delayed Function of Renal Transplant

Summary: the purpose of this study is to determine if eculizumab is safe and effective in the prevention of delayed graft function following deceased donor kidney transplantation.

based on experimental data and supportive observations in humans associating complement gene upregulation with ischemic reperfusion injury, it is hypothesized that c5 cleavage is a key step in the pathogenesis of ischemic reperfusion injury following transplantation. it is further hypothesized that eculizumab, an antibody that blocks c5 cleavage in humans will be an effective prophylactic agent to prevent ischemic reperfusion injury in high risk recipients. to test this hypothesis, this study is a pilot prospective, randomized study to test the efficacy of eculizumab vs. placebo given once at the time of transplantation in preventing delayed graft function in first adult recipients of deceased donor kidneys.

Eligibility criteria:
inclusion criteria: * age 18 or older * weight \> 40 kg * male or female * recipients of first deceased donor kidneys * able to provide written informed consent * transplant candidate as per site specific guidelines * dialysis dependent renal failure (initiated more than 2 months prior to transplant) * novartis delayed graft function score 3-8 * extended criteria donor with brain death, or standard criteria donor with cold ischemic time \< 24 hours exclusion criteria: * planned to receive multi-organ transplant * kidneys from donors \< 6 years of age * dual kidney transplant (from same donor, including en bloc) * living donor kidney * highly sensitized recipients (pra \> 50%) * previous transplant * participation in another investigational trial * recipient bmi \> 40 * abo incompatible * dcd donor * preemptive kidney transplant * recipients with dgf scores \ 8 * women who are pregnant or breast feeding * women of child bearing potential who are unable or unwilling to use a medically acceptable form of contraception * patients infected with hiv, hcv or hbv * active bacterial or other infection which is clinically significant in the opinion of the investigator * patients with history of splenectomy * patients with history of meningococcal disease * patients with known or suspected hereditary complement deficiency * patients with history of cancer (other than non-melanoma skin cancers) within the last 5 years

Keywords: kidney transplant delayed graft function
use of biofeedback training to correct abnormal neuromechanical pattern in chronic low back pain patients

Conditions: Chronic Low Back Pain; Mechanical Low Back Pain

Summary: the purpose of the present study is to evaluate the benefit of biofeedback training on the capacity of chronic low back pain patients to decrease their lumbar paraspinal muscles activity during trunk full flexion and its relationship with changes in clinical outcomes. to do so, twenty patients with nonspecific mechanical low back pain will be recruited and all participants will take part in four sessions of supervised biofeedback training, consisting of 5 blocks with at least 12 trunk flexion-extension tasks. it is hypothesized that participants will have improved neuromechanical parameters with the biofeedback training and that this improvement will be positively associated to changes in clinical outcomes. this study will also allow for generation of preliminary data, in order to plan for a larger randomized control trial.


Eligibility criteria:
inclusion criteria: * being between 18 and 60 years of age. * presence of non-specific chronic low back pain. exclusion criteria: * prior surgery or major spine trauma. * lumbar scoliosis greater than 20°. * neuromuscular disease. * malignant tumor. * uncontrolled hypertension. * infection. * neurological deficit. * symptomatic lumbar disc herniation. * pregnancy. * recent lumbar cortisone injection. * active lower body injury and/or disabling pain limiting the capacity to complete the experimentation. * being under medications known to impair physical effort and pain perception.

Keywords: low back pain rehabilitation biofeedback electromyography kinematic
studying gene expression and location in samples from patients with brain tumors

Conditions: Brain and Central Nervous System Tumors

Summary: rationale: studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors. purpose: this research studies gene expression and location in samples from patients with brain tumors.

objectives: * to determine the expression and subcellular localization of nei endonuclease viii-like 3 (neil3) in brain tumors. outline: tissue microarray samples are analyzed for neil3 expression and subcellular localization by immunohistochemical methods.

Eligibility criteria:
disease characteristics: * tissue microarrays (tma) samples from the biopathology core * samples from patients diagnosed with brain tumors * progenitor, or blast, cell origin patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: adult brain tumor childhood brain tumor
pdr and skyd of dyslipidemia's characteristics from the oxidative stress enhancement caused by inhibition of serine metabolic pathway

Conditions: Traditional Chinese Medicine; Dyslipidemias; Syndrome

Summary: clinical epidemiological investigation and modern statistics will be used. syndrome was quantified by tcm syndrome score scale. metabonomics, proteomics, transcriptomics, enzyme-linked immunosorbent assay, xanthine oxidation method and thiobarbital method will be used to detect the relevant indicators in serum, urine and tongue coating, and "disease syndrome cell model" will be constructed to detect the relevant indicators. objective to clarify the epigenetic basis, molecular biological regulation mechanism and core function characteristics of phgdh expression decline caused by pdr and skyd of dyslipidemia, analyze the correlation between phgdh, serine metabolic pathway product concentration and oxidative stress level, and reveal the scientific connotation of the disease syndrome.

clinical epidemiological investigation and modern statistics will be used. syndrome was quantified by tcm syndrome score scale. metabonomics, proteomics, transcriptomics, enzyme-linked immunosorbent assay, xanthine oxidation method and thiobarbital method will be used to detect the relevant indicators in serum, urine and tongue coating, and "disease syndrome cell model" will be constructed to detect the relevant indicators. objective to clarify the epigenetic basis, molecular biological regulation mechanism and core function characteristics of phgdh expression decline caused by pdr and skyd of dyslipidemia, analyze the correlation between phgdh, serine metabolic pathway product concentration and oxidative stress level, and reveal the scientific connotation of the disease syndrome.

Eligibility criteria:
inclusion criteria: 1. inclusion criteria of dyslipidemia with skyd and pdr. (1) subjects with dyslipidemia in accordance with the diagnostic standards and tcm syndrome diagnostic standards, (2) ranged in age from 20 to 80, (3) who signed the informed consent, and (4) without lipid-lowering medications. 2. inclusion criteria of nc. (1) healthy subjects, (2) ranged in age from 20 to 80, (3) who signed the informed consent. exclusion criteria: exclusion criteria of dyslipidemia with skyd and pdr. the exclusion criteria were composed of four criteria and a patient was excluded if they fails on any of the criteria. mentioned criteria were: (1) secondary dyslipidemia (causes of dyslipidemia include but not limited to hypothyroidism, nephrotic syndrome, chronic renal failure, liver diseases, diseases of the hematopoietic system, adrenal-corticosteroid or contraceptive-drug induced dyslipidemia); (2) aphasias, and patients had difficulties to speak or unable to extend tongue for tongue observation; (3) patients with psychosis or unable to answer questions properly; (4) patients with acute infectious diseases or in the acute disease states (such as acute myocardial infarction, acute cerebrovascular disease, etc.), as well as pregnant women.

Keywords: metabonomics syndrome dislipidemia serine metabolic pathway chinese medicine phgdh
examination of manual skills in individuals with and without chronic neck pain

Conditions: Neck Pain

Summary: this study will determine whether manual dexterity is affected in individuals with neck pain compared to individuals without neck pain. it is thought that determining the changes in dexterity in individuals with neck pain compared to healthy individuals will shed light on future more detailed studies on the current subject.


Eligibility criteria:
inclusion criteria: - experiencing neck pain for at least 3 months exclusion criteria: - having another medical condition that may affect dexterity
mindfulness and intercare based intervention for physicians burnout reduction

Conditions: Burnout; Mental Health Wellness 1

Summary: during the coronavirus disease 2019 (covid19) pandemic, many physicians have presented burnout. a range of associated factors need to be considered for effective prevention and intervention. objective 1: to assess the association of burnout in medical doctors with individual factors, self-reported medical errors, medical leave, and demands of the work environment demand. objective 2: to assess the effectiveness of a online mindfulness, compassion and intercare based intervention to reduce burnout.


Eligibility criteria:
inclusion criteria: * physicians enrolled in the database of the medical college of chile exclusion criteria: * recent grief * severe acute depression disorder * active suicidal ideation * active psychosis * active addiction * post traumatic stres disorder
musculoskeletal symptoms in post acute covid-19 patients

Conditions: Covid19; Musculoskeletal Abnormalities

Summary: the patients whose musculoskeletal symptoms initiated or aggravated with covid-19, were compared with the patients whose musculoskeletal symptoms did not change with covid-19. the variables; the demographic and treatment datas, admission symptoms, post acute-covid-19 symptoms, laboratory, chest computed tomography findings.

there is a lack of an overview of the factors associated with post acute-covid-19 musculoskeletal symptoms. the aims are;1-to evaluate the most frequent admission symptoms and the frequency of musculoskeletal symptoms in post acute-covid-19 patients,2-to determine the related factors with the post acute-covid-19 musculoskeletal symptoms. in this retrospective study; the patients whose musculoskeletal symptoms initiated or aggravated with covid-19, were compared wthe patients whose musculoskeletal symptoms did not change with covid-19. the variables; the demographic and treatment datas, admission symptoms, post acute-covid-19 symptoms, laboratory (complete blood count, c-reactive protein, ferritin, d-dimer), chest computed tomography findings.

Eligibility criteria:
inclusion criteria: * being 18 years or older * having covid-19 treatment (home quarantine / hospital / intensive care unit) according to a positive polymerase chain reaction (pcr) test in a nasopharyngeal + oropharyngeal swab or chest ct. exclusion criteria: * patients who did not have musculoskeletal symptom records (admission symptoms and musculoskeletal symptoms such as; fatigue, spine / joint /muscle pain/ numbness) in patients files * acute covid-19 patients whose symptoms started less than 1 month
drug interaction study to assess the effect of co-administered miravirsen and telaprevir in healthy subjects

Conditions: Hepatitis C; Chronic Hepatitis C

Summary: the purpose of this study is to assess the safety, tolerability, and affect on blood levels of miravirsen and telaprevir when administered together.


Eligibility criteria:
inclusion criteria: * healthy volunteers * weight ≤ 85 kg * females of non-childbearing potential (postmenopausal or surgically sterile) or males who are surgically sterile or using an acceptable form of birth control exclusion criteria: * current, clinically significant illness or medical condition

Keywords: antisense mir-122 antagonist safety in healthy volunteers hepatitis c
the effect of dates on plasma lipids, oxidative stress and the atherogenicity of serum in healthy adults

Conditions: Atherosclerosis

Summary: it has been proven in in-vitro studies that dates decrease the oxidative stress in serum. there have been no in-vivo studies to this date. the current study aims to test whether dates consumption by healthy adults decreases serum oxidative stress and improves serum pon1 activity and serum lipid profile.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: