Kornimate/medical-research-clean huggingface dataset:
evaluation and implementation of the "paediatric anesthesia emergence delirium scale" (paed) in the pacu in children under 14 years of age

Conditions: Paediatric Anesthesia Emergence Delirium

Summary: the goal of this study is to determine the incidence and characteristics of emergence delirium (ed) in children aged 0 - 13 undergoing general anesthesia and being taken care of at the paediatric pacu of the charité campus virchow-clinic. therefore the "paediatric anesthesia emergence delirium scale" (paed) is used. in order to measure the patient's pain level, age-appropriate pain scales (chipps or fps-r) are applied. risk factors for the occurrence of ed are to be determined and therapeutic approaches in case of an occurring ed are to be evaluated. finally the future implementation of ed-monitoring in the pacu is to be prepared.

emergence delirium is a widely known phenomenon during the recovery phase after general anesthesia in children. in spite of the existence of a vast number of studies dealing with this topic and even after the development of a validated measurement tool for ed (paed-scale, sikich et al. 2004), data regarding incidence, risk factors and treatment of ed vary considerably. this study seeks to determine the actual incidence and characteristics of emergence delirium (ed) in children at the paediatric pacu of the charité campus virchow-clinic. therefore the paed-scale is applied in a large population of children aged 0 - 13 years undergoing general anesthesia. in addition a clinical evaluation regarding the presence of ed is conducted by the pacu nurses on the basis of their clinical experience. in order to preserve the possibility of minimizing the influence of postoperative pain, which has been identified as a confounding variable in the measurement of ed, an age-appropriate pain score is measured simultaneously with each paed-score. the children's and infants postoperative pain scale (chipps) (büttner, 1998) is used for children aged 0 - 4 years. the faces pain scale-revised (fps-r) (hicks et al. 2001) is used for older children. besides the study aims to identify possible factors that are associated with a higher incidence of ed. therefore perioperative data (anesthetic and analgetic agents, duration of anesthesia, premedication, volume therapy etc.) is obtained. in case of the occurrence of ed additional data (duration of ed, treatment of ed) is collected. all data is collected by using a questionnaire that is completed by the anesthesists and the pacu staff.

Eligibility criteria:
inclusion criteria: * children undergoing anesthesia and being taken care of at the paediatric pacu * aged 0 - 13 years exclusion criteria: • none
a study of comparing effects of thulium laser en bloc resection and electrical transurethral resection of the non-muscle invasive bladder cancer

Conditions: Bladder Cancer

Summary: this study is to verify the short-term efficacy and long-term prognosis of thulium laser resection compared with conventional transurethral resection of non-muscular invasive bladder cancer. half of participants will receive thulium laser resection of bladder cancer, while the other half will receive electrical transurethral resection of bladder cancer.


Eligibility criteria:
inclusion criteria: 1. pathological or histological diagnosis of primary non-muscle invasive bladder urothelial carcinoma (tatist1); 2. imaging examinations showed the bladder muscle has not been affected, no lymph node metastasis or distant metastasis; 3. patients who agree to turbt surgery, and will be effected to the postoperative follow-up treatment such as conventional infusion after the operation; 4. function of main organs (heart, liver, lung, kidney) should be normal, ps score 0-2; 5. bladder capacity≥ 200ml. exclusion criteria: 1. find distant metastasis ,infiltration of the surrounding organs or relapse before operation.metastatic bladder cancer or other cancers involve the bladder; 2. received chemotherapy or bcg perfusion therapy in the nearly 3 months; 3. patients who can not tolerate the serious side effects during the bladder perfusion treatment process (bladder irritation and other symptoms); 4. patients during pregnancy ,critical care patients and patients who have other cases of surgical contraindications.such as serious cardiovascular disease,coagulation abnormalities,non-transitional epithelial tumors( such as adenocarcinoma and squamous cell carcinoma),acute cystitis,can not be supine because of spinal deformity,untreated urethral stricture.
hemodynamic and electrocardiographic effects of hyaluronidase associated with local anaesthetics

Conditions: Cardiac Arrhythmias

Summary: among the adjuvants to local anaesthetics (la), the enzyme hyaluronidase is most often used as a diffuser agent of the la in ophthalmic anaesthesia. it serves to improve clinical efficacy and prolong anaesthesia as an alternative to long-lasting and potentially more dangerous la, especially in patients with increased cardiovascular risk. there is scarce clinical data about the safety of the use of hyaluronidase in dental procedures. this study aimed to compare hemodynamic and electrocardiographic variables during a dental surgical procedure using a local anaesthetic associated with hyaluronidase or placebo in healthy subjects.

this double-blind crossover "split-mouth" trial evaluated the cardiovascular effects induced by 3.6 ml of the la 2% hcl mepivacaine with 1:100,000 epinephrine, concomitantly with 75 tru/ml hyaluronidase or placebo in inferior alveolar nerve block, for the performance of bilateral and symmetrical third molar surgery in 20 outpatients. cardiovascular parameters, including systolic blood pressure (sbp), diastolic blood pressure (dbp), and heart rate (hr), were monitored using oscillometric and photoplethysmographic methods in 10 clinical stages. electrocardiographic records (ecg) of 12 leads were obtained in four steps. hyaluronidase injected concomitantly with la did not induce changes in sbp, dbp and hr compared to placebo. there were no instances of st segment depression, st segment elevation, wide qrs complex extrasystoles, or narrow qrs complex extrasystoles. to date, few studies in dentistry have investigated the effects of local anaesthetic efficacy in hyaluronidase, and even fewer have studied the relation to systemic effects induced by this interaction. the use of la injected concomitantly with 75 tru/ml of hyaluronidase is safe when using this dose and route of administration. clinical relevance: in dentistry, few studies have investigated the effects of hyaluronidase on local anaesthetic efficacy, and even fewer have examined the possible systemic effects induced by this interaction.

Eligibility criteria:
inclusion criteria: * patients should present bilateral lower third molars (teeth 38 and 48) for extraction and identical anatomical arrangement; * absence of significant clinical morbidities, asa i (american society of anesthesiologists, 1963); * aged over 18 years. exclusion criteria: * women during pregnancy or lactation; * smokers; * history of sensitivity to any drug used in the research; * presence or history of cancer or an infectious lesion; * individuals who used any medication in the last 15 days (except oral contraceptives); * presence of abscess or pericoronitis in the region to be operated; * patients who required supplemental anaesthesia upon anaesthetic block of the inferior alveolar nerve (post-randomisation exclusion).

Keywords: local anaesthetics mepivacaine hyaluronoglucosaminidase hemodynamic electrocardiography and dentistry.
bipolar research study using mr imaging

Conditions: Bipolar Affective Disorder

Summary: in this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

there are relatively few studies evaluating brain structure in bipolar disorder (bd), the results of which have been largely inconsistent, both in terms of what abnormalities are present in bd and whether they show any similar abnormalities to those found in schizophrenia. one possibility that might explain the varying degree of reported similarity in structural findings in schizophrenia and bd is that there might be effects of bpd diagnostic subtype associated with brain structure. one viewpoint that contrasts schizophrenia and bd considers psychotic (pbd) to differ from non-psychotic (npbd) subtypes in terms of shared pathophysiology with schizophrenia. pbd has been reported as being of special interest, as it shares symptomatic overlap with schizophrenia, "runs in families", shares a chromosomal linkage to the 13q13-32 and 22q12 with schizophrenia, shows similar increases in dopamine receptor bmax induced by \[c-11\] n-methylspiperone positron emission tomography and similar working memory impairments as in schizophrenia. if pbp and npbp are associated with different forms of brain pathology, then merging the two entities into a single "bipolar group" might obscure relevant anatomic differences if these occur primarily in only one group. in this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

Eligibility criteria:
inclusion criteria: * between the ages of 18-30 * diagnosed with bipolar disorder exclusion criteria: * history of head injury * unstable medical condition

Keywords: bipolar disorder magnetic resonance imaging (mri) scanning
real-world dosing patterns of rivaroxaban in the united states

Conditions: Atrial Fibrillation

Summary: the primary objective is to assess the proportion of non-valvular atrial fibrillation (nvaf) patients receiving the standard dose of 20 mg of rivaroxaban or the reduced dose of 15 mg of rivaroxaban. the secondary objective is to determine if dosing patterns for rivaroxaban may be influenced by baseline chronic kidney disease (ckd) status (as a proxy for measured baseline renal function).


Eligibility criteria:
inclusion criteria: * nvaf (non-valvular atrial fibrillation) will be defined as the occurrence of 2 or more inpatient or outpatient claims with international classification of disease icd-9 427.31 as the diagnosis code at any time in the patient's data history prior to inclusion * patients will be required to have 180 days of enrollment for the assessment of baseline characteristics * cha2ds2-vasc score ≥2 during the 180 days prior to index rivaroxaban use baseline period * evidence of continuous enrollment in marketscan during 180 days before the date of the first prescription of rivaroxaban exclusion criteria: * patients \<18 years of age * patients with valvular af (atrial fibrillation) * pregnancy * malignant cancers * transient cause of af * patients with vte (venous thromboembolism), pulmonary embolism or dvt (deep vein thrombosis) * patients with major surgery defined as hip or knee replacement * prescriptions of oacs (oral anticoagulants) (apixaban,warfarin, dabigatran, rivaroxaban) before index date * prescription of more than one oac on the index date

Keywords: non-valvular atrial fibrillation (nvaf) prevention stroke
the effect of blood tests performed within the routine protocol in the surgical intensive care unit on hemoglobin levels

Conditions: Anemia

Summary: examination of blood samples is inevitable in intensive care units. routine blood samples can be an important cause for anemia. in this study, we aimed to examine how our blood collection routine affects hemoglobin values.

blood tests for follow-up and treatment are widely used in intensive care units (icu). although its etiology is very diverse, phlebotomy performed due to frequent laboratory tests is among the preventable causes of anemia. in this observational study, blood tests performed on patients treated in intensive care units followed up in our clinic between 01.april.2023 - 31.may.2023 (2 months) will be examined. patients' age, presence of additional disease, indication for admission to the unit, acute physiology and chronic health assessment ii (apache ii), sequential organ failure assessment (sofa) and glasgow coma scale (gcs), hemoglobin values will be recorded. the daily blood test will record the amount of blood drawn for analysis (in milliliters), where it was taken from (peripheral, central venous or arterial catheter), and the amount of excess blood. statistical analysis will be performed in terms of patient characteristics, routine blood volumes and development of anemia.

Eligibility criteria:
inclusion criteria: * patients followed in the intensive care unit for more than 48 hours, ≥18-year-old exclusion criteria: * patients not followed up by our clinic,≤18-year-old

Keywords: intensive care unit routine blood sample overdrawn
diaphragmatic movement before and after stellate ganglion block : a ultrasonographic study

Conditions: Head Pain; Neck Pain; Shoulder Pain; Arm Pain; Neural Sensory Hearing Loss

Summary: the temporary diaphrgmatic dysfunction will occur after stellate ganglion block(sgb) and will be easily detected by m-mode ultrasonography


Eligibility criteria:
inclusion criteria: * asa class i-ii patients who have head and neck pain or shoulder pain or sudden sensory neural hearing loss exclusion criteria: * coagulopathy, pulmonary disease, neuropathy
effects of intraoperative normal saline vs lactated ringer on outcomes in pediatric liver transplantation

Conditions: Biliary Atresia Intrahepatic Syndromic Form

Summary: lactated ringer(lr) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. however, the utility of lr in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. in addition,large amounts of normal saline(ns) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative ns or lr on outcomes in pediatric receiving liver transplantation.


Eligibility criteria:
criteria inclusion criteria: 1. pediatric patients between the age of 3 month and 6 years 2. scheduled for living donor liver transplantation exclusion criteria: 1. re-transplantation 2. combined liver and kidney transplantation 3. congenital heart disease 4. refused to participate the study
endometriosis self-care behaviors scale

Conditions: Endometriosis; Self Care; Behavior; Nursing Role

Summary: in this study, it was aimed to develop a reliable and valid scale to measure the self-care behaviors of women with endometriosis.

in this study, it was aimed to develop a reliable and valid scale to measure the self-care behaviors of women with endometriosis.this research is of methodological type.data will be collected by using "participant description questionnaire" and "self-care behaviors scale in endometriosis".

Eligibility criteria:
inclusion criteria: * reproductive age, * diagnosed with endometriosis, * having no medical or gynecological problems other than endometriosis, * able to read and write, * not pregnant, * no barriers to communication, * not diagnosed with a psychiatric illness, * volunteer to participate in the study, * women who can speak and understand turkish will be included. * followed for at least 6 months, * having symptoms related to endometriosis, exclusion criteria: • women who incomplete in the data collection forms incompletely will be excluded from the study.
subconjunctival humira for boston keratoprosthesis

Conditions: Penetrating Keratoplasty; Multiple Graft Failure; Ocular Cicatricial Pemphigoid; Stevens-Johnson Syndrome

Summary: this trial is studying the safety and tolerability of receiving an injection of adalimumab (humira) during the boston keratoprosthesis (kpro) surgery.

this is a phase i, open-label, ind trial for participants undergoing a boston keratoprosthesis (kpro) procedure, to receive an injection of adalimumab (humira), to study the safety and tolerability as well, to study whether there is a decrease to post surgical complications, and symptoms that participants would experience, if they did not receive the injection. the study will recruit eight (8) participants, who will be monitored for thirty (30) days after the surgery, through eye examination and eye photos.

Eligibility criteria:
inclusion criteria: * age 18 years or older * individuals eligible for keratoprosthesis surgery, as determined by standard-of-care eligibility criteria * patients with poor prognosis for corneal transplantation, severe corneal opacity and/or vascularization * patients with vision worse than 20/200 in the eligible eye, and contralateral eye with vision less than 20/40 * patients with intact nasal light projection * willing and able to comply with study plan for the full duration of the study * willing and able to sign a written informed consent exclusion criteria: * active tuberculosis or untreated latent tuberculosis (e.g., positive interferon-# release assay \[igra\] test, such as quantiferon-gold) * untreated active hepatitis b or c infection. * ocular or periocular malignancy and/or infection * inability to wear contact lens * pregnancy (positive pregnancy test) or lactating * participation in another interventional study at the time of screening * any of the following baseline lab values 1. white blood count \<3500 cells per microliter 2. platelets \<100,000 per microliter 3. hematocrit \<30% 4. ast or alt \>1.5x upper limit normal value * multiple sclerosis or other demyelinating disease * severe uncontrolled infection * moderate to severe heart failure (nyha class iii/iv) * active malignancy * history of adalimumab intolerance * pregnancy or lactation * medical problems or drug or alcohol dependence problems sufficient to prevent adherence to treatment and study procedures. * as judged by the investigator any patients that are questionable for their suitability in the study

Keywords: kpro boston kpro keratoprosthesis type-1 boston kpro
comparison of pulmonary function and efficacy of different nerve block catheters for shoulder surgery

Conditions: Post-Operative Pain

Summary: this study is designed to evaluate lung function and pain control of continuous supraclavicular versus suprascapular versus interscalene nerve catheters in subjects undergoing total shoulder replacement. the investigators hypothesize that all three groups would have similar pain control; the supraclavicular and suprascapular groups may have better lung function.


Eligibility criteria:
inclusion criteria: * unilateral total shoulder arthroplasty * asa physical status i-iii * \>18 years old * non-pregnant (or lactating) * consent to participate in the study exclusion criteria: * refusal to participate * \< 18 years old * chronic opioid use * localized infection * pregnancy or lactating * pre-existing coagulopathy * allergy to ultrasound gel or local anesthetics * diaphragmatic dysfunction
phase i single dose-escalation safety study of human glucocerebrosidase (prgcd)

Conditions: Gaucher Disease

Summary: gaucher disease, the most prevalent lysosomal storage disorder, is caused by mutations in the human glucocerebrosidase gene (gcd)leading to reduced activity of the lysosomal enzyme glucocerebrosidase and thereby to the accumulation of substrate glucocerebroside (glccer)in the cells of the monocyte-macrophage system. this is the first trial to utilize a recombinant active form of lysosomal enzyme, glucocerebrosidase, (human prgcd)which is expressed and purified in a bioreactor system from transformed carrot plant root cell line.


Eligibility criteria:
inclusion criteria: 1. healthy male or female between 18 and 45 years of age. 2. female subjects must agree to use a medically acceptable method of contraception at all times during the study and must have a negative serum pregnancy test at baseline and during the study period. 3. females of child-bearing potential must be non-pregnant and not lactating and using adequate birth control such as oral contraceptives. 4. negative laboratory tests for hiv, hbsag or hcv. 5. naive to any previous recombinant protein therapy. 6. provide written informed consent. 7. have the ability to understand the requirements of the study and to comply with the study protocol and dosing regimen. exclusion criteria: 1. have clinical evidence of any active significant disease that could potentially compromise the ability of the investigator to evaluate or interpret the effects of the study treatment on safety assessment and thus increase the risk to the subject to unacceptable levels. 2. are pregnant or nursing. 3. presence of any acute or chronic diseases. 4. have a history of any allergies. 5. have been exposed to long-term steroid treatment. 6. had a minor operation in the last 6 months. 7. have ever been exposed to any previous recombinant protein therapy. 8. have received immuno-suppressive treatment. 9. have a positive hiv, hbsag and hcv laboratory result. 10. use any medication other than vitamins or oral contraceptives (for female). 11. have participated in another clinical trial during the previous 3 months 12. have history of alcohol or drug abuse. 13. are considered by the investigator to be unsuitable candidate for this study.
impact on family or care-givers of very old icu-survivors, trajectories and 6 months' outcome in the very old.

Conditions: Functionally-Impaired Elderly; Caregivers; PTSD; Depression, Anxiety; Intensive Care Unit Syndrome

Summary: it is known from extensive documentation that second victims in critical illness often are the care givers of the patients: family, friends or other persons. although this has not been specifically studied in the very old patients, there is no reason to believe that this group will be different from other icu patients. even more so, in this very old age patient group there are seldom any older relatives. partners, like wife/husband or other cohabitants, may be dead or themselves incapacitated. many will be in institutional care. the closest care-givers will be middle-aged people such as children or others, if no partners are available. the hypothesis is that critical illness can be a large stressor to care-givers of survivors in the vip measured as the occurrence and severity of the usual problems like ptsd and depression. the investigators hypothesize that a low-threshold on-line support program decreases the magnitude of anxiety, depression and ptsd for care-givers of very old intensive care patients (vip) after discharge.

aims of the study * results from family/care givers experience: degree of involvement with post-icu care, impact on their own health (depression, ptsd, burden questionnaire) * effect of a simple intervention: on-line support and/or telephone advice on return to pre-icu frailty score (patients) and occurrence of ptsd and depression in care-givers * information on 6 months' outcome (frailty and mortality) in very old survivors after icu in different european countries * information on trajectories in the time after discharge: dead/alive, home, nursing home, new hospital admissions, living with family/other care-givers, etc.

Eligibility criteria:
inclusion criteria: * hospital survivors after any icu admission exclusion criteria: * imminent terminal care