Kornimate/medical-research-clean huggingface dataset:
follow-up strategy of chronic hepatitis b for early detection and diagnosis of hepatocellular carcinoma: a randomized control trial

Conditions: Chronic Hepatitis B

Summary: this study is a randomized control prospective study. the aim of this study is to establish an all-round and convenient follow-up strategy of chronic hepatitis b for early detection and diagnosis of hepatocellular carcinoma (hcc), by investigating whether different surveillance time intervals and surveillance methods are beneficial for chronic hepatitis b and cirrhotic patients with different risk of hcc.

surveillance of chronic hepatitis b and cirrhotic patients had been demonstrated to increase chances of curative treatment for hepatocellular carcinoma. however, the optimal surveillance interval for different risk patients is still controversial. the aasld and easl-eortc guidelines recommend chronic hepatitis b patients undergoing ultrasound surveillance at a time interval of 6 months, but the japanese hcc guideline recommend the very-high risk patients undergoing ultrasound surveillance at a time interval of 3 or 4 months. the incidence of hcc is 0.3%-0.8% in the chronic hepatitis b patients and 2%-8% in cirrhotic patients, thus recalling a different follow-up strategy for different stage of chronic hepatitis b patients. besides, ultrasound is the admitted surveillance tool for hcc for its convenience and cost-effectiveness. however, the sensitivity of ultrasound detecting hcc will remarkably decrease because of the influence of ribs, pulmonary and gastrointestinal gas, cirrhosis and fatty liver. so it is necessary to incorporate computed tomography (ct) or magnetic resonance imaging (mri) into the follow-up strategy of very high risk patient such as patients with cirrhosis or history of hcc. the aim of this study is to investigate whether different surveillance time intervals and surveillance methods are beneficial for chronic hepatitis b and cirrhotic patients with different risk of hcc, ultimately establish an all-round and convenient follow-up strategy of chronic hepatitis b for early detection and diagnosis of hcc.

Eligibility criteria:
inclusion criteria: 1. hbv-ag positive( \>6 months) 2. age among 18 and 80 years exclusion criteria: 1. patients with hepatocellular carcinoma 2. patients were diagnosis hepatocellular carcinoma within 3 months of inclusion; 3. patients with alcoholic hepatitis or autoimmune hepatitis 4. patients with severe uncontrolled disease resulting in estimated life expectance less than 1 year 5. coinfection with human immunodeficiency virus(hiv) 6. cannot undergo contrast-enhanced imaging 7. refuse attending the study

Keywords: surveillance hepatocellular carcinoma ultrasound cirrhosis chronic hepatitis b
southampton women's survey covid-19 study

Conditions: Mental Health Wellness 1

Summary: the current covid-19 pandemic has brought many challenges with implications for wellbeing and mental health. the southampton women's survey provides the opportunity to understand influences on these important outcomes amongst women and their offspring in the context of an established longitudinal cohort study.

between 1998 and 2002 the southampton women's survey (sws) team interviewed 12,583 southampton women aged 20 to 34 years. the baseline survey collected data on women's diets, lifestyles, body and blood measures, reproductive health, education, mental health and social circumstances. of these participants, 3,158 women subsequently became pregnant within the study period and delivered a liveborn singleton infant. the survey has followed up the offspring and mothers with home visits at six months, one, two and three years. a sample of over 1,000 offspring was seen at 4 years of age, more than 2,000 offspring were seen at ages 6-7 years, and more than 1,000 at 8-9 years. follow-up of offspring aged 11-13 years is being completed and at 17-19 years is being piloted. the women are currently aged 37 to 57 years and the offspring are currently aged 12 to 21 years. the covid-19 pandemic has brought unique challenges across the population. the effects include those of the threat of the virus itself as well as the impact of the government-imposed lockdown on health and wellbeing. research in many contexts will allow greater understanding of the repercussions of this unprecedented event. the southampton women's survey provides an opportunity to understand the effects of the lockdown on a well-characterised cohort of women and their adolescent/young adult offspring. the longitudinal data available in the cohort will provide a unique opportunity to understand how circumstances earlier in life (including pre-pregnancy) influence people's health and wellbeing during the pandemic. objectives: 1. to collect individual level data relating to health and wellbeing during the covid-19 pandemic amongst sws women and their offspring. 2. to assess whether lockdown-specific pressures such as working from home, home schooling and lack of social contact are associated with health and wellbeing during the pandemic. 3. to use longitudinal data to understand how health and lifestyle in earlier life (including pre-pregnancy) are associated with health and wellbeing during the pandemic.

Eligibility criteria:
inclusion criteria: * women with offspring born in the southampton women's survey (original project) * offspring born in the southampton women's survey (original project) exclusion criteria: * anyone who was not a part of the original project
an effect of an individualized physical activity intervention for gastric cancer patient undergoing minimally invasive gastrectomy: a phase iii, prospective randomized controlled trial

Conditions: Gastric Cancer

Summary: gastric cancer is a major health issue and one of the most common malignance in korea. with the popularization of cancer screenings and increasing the average lifespan, the number of gastric cancer patients is increased. in the past, most of the research were concerned with survival and recovery after cancer surgery. however, as the medical technology had been developed and recovery rate and survival rate of cancer patients had risen, the patients wanted to return to a daily life and desire for participation for leisure. in other words, the patients who underwent surgery wants to maintain a high quality of life(qol) level as like prior to cancer surgery.

there are many reports on the effect of the exercise program after cancer surgery. in addition, exercise program was associated with improving the qol and functional recovery, decreasing a mood of depression, maintaining a muscle mass and improving the survival rate. however, the subject patients of previous studies were western people. therefore, the results were not disclosed whether the exercise program suited to the body characteristics of korean people. furthermore there was no exercise program studies for the gastric cancer patients. medical service for cancer patients care should include not only diagnosis, treatment as like surgery but efforts on enhancing the quality of life. in other words, post-management education and management program as like exercise program are necessary for the cancer patients after surgery. thus, the investigators have done the pilot study about how to practice the exercise program and how to evaluate the effect on the recovery. based on the result of pilot study which could identify the safety and the feasibility , the investigators would like to do a prospective randomized controlled study to prove the effect of exercise program after surgery

Eligibility criteria:
inclusion criteria: 1. early gastric cancer patients 2. undergoing minimally invasive surgery 3. age: 20-70 4. ecog: 0-1 5. a patient who did not exercise regularly for the last 6 months 6. a patient who signed the informed consent exclusion criteria: 1. pregnancy or plans to become pregnant 2. cognitive disabilities 3. other primary cancer history 4. history of major abdominal surgery except current surgery 5. cardiopulmonary medical comorbidity 6. living \> 60 km from the hospital

Keywords: gastric cancer minimally invasive gastrectomy physical activity intervention
a clinical study to assess the effects of a stannous fluoride dentifrice on plaque and gingivitis

Conditions: Gingivitis

Summary: the objective of this clinical study is to assess the effects of a 0.454% stannous fluoride dentifrice on gingivitis and plaque after 3 months when compared to a negative control.


Eligibility criteria:
inclusion criteria: * be at least 18 years of age; * provide written informed consent prior to participation and be given a signed copy of the informed consent form; * be in general good health as determined by the investigator based on a review of the health history/update for participation in the trial; * have at least 16 gradable teeth; * agree to return for scheduled visits and follow the study procedures; * agree to refrain from use of any non-study oral hygiene products for the duration of the study; * agree to delay any elective dentistry, including dental prophylaxis, until the completion of the study; exclusion criteria: * having taken antibiotic, anti-inflammatory, or anti-coagulant medications within 4 weeks of the baseline visit; * have any oral conditions that could interfere with study compliance and/or examination procedures, such as widespread caries, soft or hard tissue tumor of the oral cavity, or advanced periodontal disease; * removable oral appliances; * fixed facial or lingual orthodontic appliances; * self-reported pregnancy or lactation; * any diseases or condition that might interfere with the safe participation in the study; and * inability to undergo study procedures.
urine cytology and utility in bladder recurrence

Conditions: Bladder Cancer

Summary: review bladder cancer patients and form a database in regards to urine cytology.

in 2008 there was an estimated 68,810 new cases of bladder cancer, and 14,100 deaths. on the list of morbidity due to cancer, bladder cancer ranks number nine, yet is number one in dollars spent per cancer diagnosis and treatment. guidelines include cystoscopy and cytology/urine study every three months for the first 2 years and then every 6 months for the next 2 years, with the cycle being reset with every recurrence. urine cytology currently considered the gold standard for urine tests has many pros and cons. the points that keep it in use include: its high specificity, the ability to detect upper tract occurrence, and the ability to monitor the small population of those with bladder cancer whose disease becomes more aggressive. opponents to cytology refer to the fact that is has low sensitivity that it is fairly subjective and that newer markers in comparison are improved. there are multiple journal article which document the performance of cytology and the newer markers, the new markers versus cytology and then the performance of cytology in tandem with these new markers. the bottom line that is often overlooked is that cytology is expensive and each of the newer markers are at least as expensive as cytology. with the fact that a person who is diagnosed with non invasive bladder cancer can have up to 13 urine cytology's in 5 years without any recurrence we believe newer rational recommendations need to be made in regards to urine studies and bladder cancer follow up.

Eligibility criteria:
inclusion criteria: * bladder cancer patients from dr. jay hollander's private practice. exclusion criteria: * patients with diagnosis of bladder cancer without initial cytology available. * patients who received outside nephrectomy or cystectomy without pathology available. * those who had recurrence without cytology results available. * those who were followed by dr hollander and another urologist in which records are missing for a significant number of follow ups.

Keywords: bladder cancer cytology
safety surveillance of vaxigriptetra® and efluelda® influenza vaccines in europe during the influenza season 2023/24

Conditions: Influenza Immunization (Healthy Volunteers)

Summary: this epss will determine the vaccinee reporting rates (rrs) of suspected adrs following routine vaccination with vaxigriptetra® and efluelda® respectively, during the nh influenza season 2023/24. the primary objective of this surveillance is to estimate the vaccinee reporting rate (rr) of suspected adverse drug reactions (adrs) occurring within 7 days following routine vaccination with vaxigriptetra® and efluelda® respectively, during the northern hemisphere (nh) influenza season 2023/24. study duration per participant 2 months (including 6 weeks for vc distribution 2 weeks for vaccinee reporting) following the first vaccination


Eligibility criteria:
inclusion criteria: there are no formal inclusion criteria. individuals who approach the site for vaccination and agree to receive a vaccination card will be included and vaccinated with the respective vaccine brand according to the country of their location, recommendations for the individual vaccines as well as national recommendations exclusion criteria: -
subthreshold laser treatment for reticular pseudodrusen and geographic atrophy secondary to amd

Conditions: Age-Related Macular Degeneration; Geographic Atrophy; Reticular Pseudodrusen

Summary: to evaluate the effectiveness of subthreshold laser treatment on retinal sensitivity in patients with reticular pseudodrusen and incipient geographic atrophy (ga) secondary to age-related macular degeneration (amd). secondary objective is to investigate changes in best-corrected visual acuity, atrophy progression and safety.


Eligibility criteria:
inclusion criteria: * ga \< 0.5 disk areas secondary to amd and/or reticular pseudodrusen * 50 years or older * the periphery of the atrophic lesions must demonstrate increased autofluorescence * best corrected visual acuity between 20/20 and 20/400 inclusive * clear ocular media * ability to provide informed consent and attend all study visits exclusion criteria: * ga secondary to other causes aside from amd * evidence of choroidal neovascularization in either eye * any prior treatment for amd, aside from antioxidants * any other ocular condition that would progress in the study period and confound visual acuity assessment * any ocular or systemic medication known to be toxic to the lens, retina or optic nerve * presence of idiopathic or autoimmune-associated uveitis * any intraocular surgery 3 months of entry * any prior thermal laser in the macula * history of vitrectomy, filtering surgery, corneal transplant or retinal detachment surgery * previous therapeutic radiation in the ocular region in either eye * any treatment with an investigational agent in the previous 60 days before study entry * women of child-bearing potential, defined as all women less than 1 year postmenopausal or less than 6 weeks since sterilization at baseline, unless they are using highly effective methods of contraception during dosing of study treatment * participation in an investigational drug, biologic, or device study within 6 months prior to baseline \[note: observational clinical studies solely involving over-the-counter vitamins, supplements, or diets are not exclusionary

Keywords: age-related macular degeneration geographic atrophy reticular pseudodrusen lasers pascal 577
nitrx total knee arthroplasty rsa

Conditions: Total Knee Arthroplasty; Knee Osteoarthritis; Radiostereometric Analysis

Summary: metal hypersensitivity is a recognized complication in some patients following total joint arthroplasty. this can result in a reaction to metal particles from the implants placed in the joint and cause tissue injury. the evolution® nitrx™ (microport orthopaedics, memphis, tn) knee implant was designed with the addition of a coating meant to create a barrier against the release of metal ions. the primary purpose of this study is to compare the evolution and evolution nitrx implant (implants your surgeon uses in total knee arthroplasty surgery). this study will compare the stability of these knee implants (any movement the implant makes after surgery) through the use of specialized xrays, called "radiostereometric analysis" (rsa for short). the investigators will also compare levels of circulating metal particles with blood draws and the effects of any circulating metal with mr imaging. the investigators will also be looking at the participants clinical outcomes using joint function and patient satisfaction questionnaires. a total of 50 patients will be enrolled into the study.


Eligibility criteria:
inclusion criteria: * symptomatic osteoarthritis of the knee indicating primary total knee arthroplasty * varus knee deformity of 0 to 10 degrees * sufficient ligamentous function to warrant retention of the posterior cruciate ligament * between ages of 21 and 80 inclusive * patients willing and able to comply with follow-up requirements and self-evaluations * ability to give informed consent * no contraindications to magnetic resonance imaging (mri) exclusion criteria: * active or previous infection * medical condition precluding major surgery * inflammatory arthropathy * prior patellectomy * pcl deficiency * major coronal plane deformity * valgus deformity * bone defects requiring augments, cones and/or stemmed implants
ioct for patients with diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: patients will be examined before and after surgery with a stand-alone oct and intraoperative microscope integrated oct

48 patients with and 48 patients without diabetic macular edema will be recruited for the study. macular thickness measured with a stand-alone oct and an intraoperative oct will be assessed before and after phakoemulsification with intraocular lens implantation.

Eligibility criteria:
inclusion criteria: * cataract with the indication for surgery (visual symptoms) for both groups (study and control group) * diabetic macula edema - for the study group * age 21 and older * written informed consent prior to surgery exclusion criteria: * any relevant corneal disease * in case of pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)
treatment of sarcopenia in post-hip fracture patients (0677-032)

Conditions: Hip Fracture

Summary: the purpose of this study is to demonstrate an improvement in physical functional recovery, following administration of drug for 24 weeks, in patients who have recently experienced a hip fracture. this study will also evaluate the safety and tolerability of drug. this is an early phase trial and some specific protocol information is proprietary and not publicly available at this time. (full information is available to trial participants).


Eligibility criteria:
inclusion criteria: * patient has had surgery for a unilateral hip fracture, and is considered to be partially or fully weight bearing after the surgery * surgical repair of the fracture has occurred no more than 4 days post hip fracture * prior to starting the study medication, the patient is enrolled in a rehabilitation program (as an in-patient or as an out-patient) * patient is judged to have been able to ambulate independently at home prior to their hip fracture (able to walk indoors in a familiar setting with little or no aid from another person) exclusion criteria: * patient has an unstable medical condition * patient has a hip fracture that is due to bone pathology other than osteoporosis (e.g., malignancy, or paget's disease), or major trauma (e.g. motor vehicle accident). * patient has type i diabetes * patient has type ii diabetes with any of conditions; 1. patient is currently taking more than one anti-hyperglycemic agent, or is taking a single combination anti-hyperglycemic drug containing more than one anti-hyperglycemic medication 2. patient is currently receiving insulin. note: a short-term course of insulin required for glycemic control post hip fracture surgery is not exclusionary 3. patient has diabetic retinopathy 4. patient is unwilling or unable to monitor glucose at home * patient has been diagnosed with any neuromuscular or neurological disease causing muscle weakness * patient has cancer, or had a diagnosis of any malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or adequately treated in situ cervical cancer * patient has active carpal tunnel syndrome * patient was living in a nursing home prior to the hip fracture (note: - patients who were living in an assisted-living facility prior to the hip fracture are eligible for enrollment) * patient was permanently wheelchair bound prior to the hip fracture
ultrasound, peds body composition, and neurodevelopmental outcomes

Conditions: Prematurity

Summary: the overall objective of the proposal is to evaluate the ability of ultrasound to predict the body composition of toddlers in the outpatient clinical setting and to evaluate the relationship between body composition and neurodevelopment.

the investigators will address the hypothesis in the following specific aims: specific aim 1: validate ultrasound as a method to measure whole body fat mass and fat-free mass in toddlers. body composition will be assessed using ultrasound measurements and the validated method of air displacement plethysmography (adp). specific aim 2: determine the effect of a handheld force-measuring ultrasound probe on intra- and inter-observer variability in ultrasound measurements. a device which measures the force applied to the ultrasound probe will be used to obtain measurements of muscle and adipose tissue thickness (biceps, abdomen, and quadriceps) in toddlers.

Eligibility criteria:
inclusion criteria: * toddlers who were ≤ 36 weeks gestational age (ga) at birth who attend the university of minnesota masonic children's hospital nicu follow up clinic * written consent obtained from a parent before or at time of visit exclusion criteria: * toddlers who require medical support that prevents them from having adp measurements taken * those with an inability to sit in a supported seat for 5 minutes * those weighing less than 10 kg
effect of site on pain in preterm neonates

Conditions: Great Premature Newborn

Summary: numerous experimental and clinical studies have shown that preterm neonates are particularly sensitive to stress. preterm neonates routinely undergo painful invasive procedures. each situation causing pain or discomfort can alter their development and cause short term cardiovascular consequences but also have long-term neurocognitive influences. repetitive procedural pain can also lead to changes in the pain sensitivity threshold therefore. the most common painful procedures are lancing for blood glucose testing. in adults, infants and term newborns, forearm blood glucose testing has been demonstrated to be less painful than conventional sites (heel, fingers). but data is lacking in preterm neonates. the primary purpose of this study is to demonstrate a significant reduction in pain response during forearm blood lancing vs conventional sites (fingers, heel) in preterm neonates born up to 32 weeks gestation. this study is an interventional multicenter (3 centers), randomized, double bind trial with a cross over assignment. 60 premature neonates born between 23 to 32 weeks. gestation with a postnatal age less than 72 hours that will undergo at least 3 blood glucose pricks will be included. the different sites will be randomly successively tested.


Eligibility criteria:
inclusion criteria: * premature neonates 23 to 32 weeks gestation * infant born with a postnatal age greater than or equal to 3 hours and less or equal to 72 hours * infant born with at least 3 blood glucose testing in less than 72 hours exclusion criteria: * severe congenital anomalies that could alter pain perception or expression * extremities congenital anomaly impeding blood glucose testing on different sites * infants born to mothers known to be receiving opiates * severe haemodynamic disturb * severe neurologic injury * neonate with opioids or sedatives medications * no parental consent