Kornimate/medical-research-clean huggingface dataset:
conjunctival flora before cataract surgery: a microbiological evaluation

Conditions: Endophthalmitis Following Cataract Surgery

Summary: the purpose of the present study is to elucidate the qualitative and quantitative variation of ocular flora after treatment with eyedrops containing 0.6% povidone-iodine in the eye of patients undergoing routine cataract surgery.

two conjunctival swabs will be executed at 3 days before and at the day of routine cataract surgery in each eye of patients undergoing routine cataract surgery. after the collection of the first conjunctival swab a three-days treatment with eyedrops containing 0.6% povidone-iodine in the eye undergoing routine cataract surgery will be performed. bacterial isolates will be identified by using standard microbiological protocols and total bacterial load will be determined at the two different time points. in vitro susceptibility testing to determine methicillin resistance in isolated staphylococcus species will be performed. controlateral eye of each patient will be used as control. descriptive statistics will be calculated.

Eligibility criteria:
inclusion criteria: * informed consent * males and females aged between 40 and 80 years * patients who are candidates for cataract extraction exclusion criteria: * males and females under 40 years and over 80 years * previous diseases of the eye, ocular surface and thyroid disease * known hypersensitivity to the product * presence of autoimmune diseases * pregnancy or breast-feeding * participation in other clinical studies

Keywords: cataract endophthalmitis microbiological evaluation
postoperative care of sutured wounds

Conditions: Wound Healing

Summary: the primary objective of this study is to compare the efficacy of hydrogen peroxide versus normal saline in postoperative care of sutured wounds. subjects will be randomly assigned to standard of care hydrogen peroxide or standard of care normal saline in postoperative care of sutured wounds followed by applying petroleum jelly and sterile gauze bandage. data will be collected at day 0 and between days 7 to14. subjects will provide irritation scale rating (0-4) with 0 being none/absent and 4 being severe/extreme.


Eligibility criteria:
inclusion criteria: 1. patients who are undergoing sutured wound after dermatologic procedure. 2. males and females ages 18-65 years old. 3. patients who are in good health. 4. willingness and the ability to understand and provide informed consent and communicate with the investigator/study staff. exclusion criteria: 1. history of keloids or hypertrophic scars. 2. history of bleeding tendency or coagulopathy. 3. pregnant or lactating or intends to become pregnant in the next 3 months. 4. active skin disease or skin infection in the treatment area. 5. unable to understand the protocol or to give informed consent. 6. any other condition that would, in the professional opinion of the investigator, potentially affect response or participation in the clinical clinical study, or would pose as an unacceptable risk to the subject.
fluid kinetics in patients with diabetic ketoacidosis

Conditions: Diabetes

Summary: the purpose with the study is to follow the fluid shifts that occur during fluid resuscitation of patients with diabetic ketoacidosis. in the study measurements of changes in blood and urine concentrations of sodium and chloride as well as blood hemoglobin are used to mathematically calculate changes in distribution volumes of these different endogenous markers.

patients treated for diabetic ketoacidosis receive 1000 ml of sodium chloride during the first 30 minutes of treatment. before, during and after this infusion regular blood samples(and urine) are collected (0, 10, 20, 30, 35, 40, 45, 50, 60, 120, 180 and 300 minutes after infusion start). b-hemoglobin, p-albumine, b-glucose, p-sodium, p-potassium. p-chlorides, u-sodium, u-chloride and u-glucose. hourly volume of urine is measured. the 30 minute infusion can be used to calculate the urine extracellular volume. thereafter during infusion of ringers acetate changes in electrolytes in blood as well as urine volume and in the urine excreted electrolytes can be used to calculate the fluid shifts between the different fluid compartments. eventually 8 to 12 hours later a second infusion of sodiumchloride is as a control performed.

Eligibility criteria:
inclusion criteria: * diabetic ketoacidosis needing icu care, conscious patient, signed informed consent. exclusion criteria: * unconscious patient

Keywords: diabetes ketoacidosis fluid shift
iplasma il6, procalcitonin and vegf and dialysate level in capd patients

Conditions: Chronic Kidney Disease

Summary: the aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of vegf, inflammatory cytokines (il- 6, procalcitonin) and pstr, dialysis adequacy in capd patients.

this cross -sectional study measured il-6, procalcitonin and vegf level in plasma and overnight effluent. pstr of small solutes was evaluated by standard peritoneal equilibration test (standard pet). weekly kt/v and creatinine clearance (ccr ) were evaluated in all patients.

Eligibility criteria:
inclusion criteria: * stable capd patients without previous history of peritonitis exclusion criteria: * hiv * other infections, tuberculosis or on immunosuppressive drugs, * autoimmune disease, * cancer * diagnosis of permanent ultrafiltration failure .

Keywords: capd peritoneal solute transport rate dialysis adequacy
exploring the efficacy and safety of rivaroxaban to support elective percutaneous coronary intervention

Conditions: Cardiovascular Disease; Coronary Artery Disease

Summary: balloon angioplasty (percutaneous coronary intervention (pci)) is commonly used to treat patients with obstructive coronary artery disease (cad). although pci is highly effective for the management of cad, it can potentiate an existing prothrombotic state around lesion areas. a certain level of anticoagulation is required to perform planned pci safely and to minimize the periprocedural risk of thrombosis and its attendant complications, including myocardial ischemia and infarction (heart attack). many different anti-thrombotic regimens have been investigated and are currently in use. the aim of this study is to explore whether rivaroxaban, as compared to unfractionated heparin, on the background of standard dual antiplatelet therapy, can effectively suppress thrombosis and related adverse ischemic events, upon balloon inflation and stent expansion, during elective pci, without increasing bleeding. the treatment assignment will be done in a semi-blinded design, eg, no blinding for randomization either to rivaroxaban (one of the three arms) or the control (ufh) group. however, all will be blinded for the treatment dose of rivaroxaban (either 10mg or 20 mg).the 10 mg rivaroxaban plus 50 iu ufh arm will not be blinded.


Eligibility criteria:
inclusion criteria: * male or female subject aged 18 years or more with no upper age limit and willing to comply with the protocol * symptomatic coronary artery disease due to undergo an elective (non-emergent) percutaneous coronary intervention (pci) on one or two lesions in the native coronary vessel(s). cardiac standard troponin at baseline is within the normal limits exclusion criteria: * conditions that may increase the risk of the pci procedure * conditions that may increase the risk of bleeding * significant valvular heart disease * calculated creatinine clearance ≤30 ml/min * current use of anticoagulant drugs including vitamin k antagonist (vka), factor iia or factor xa inhibitors * chronic treatment with non-steroidal anti-inflammatory drugs (nsaids) * chronic treatment with aspirin \> 100mg

Keywords: angioplasty, balloon, coronary
video-assisted surgery in treating patients with non-small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: video-assisted surgery may be an effective treatment and have fewer side effects than conventional surgery in patients with non-small cell lung cancer. purpose: phase ii trial to study the effectiveness of video-assisted surgery in treating patients who have non-small cell lung cancer.

objectives: i. determine the feasibility of performing video-assisted thoracic surgery (vats) lobectomy, without significant morbidity or perioperative mortality, in patients with small (no greater than 3.0 cm), peripheral, non-small cell lung cancer. ii. determine the rate at which a thoracotomy must be carried out to complete a vats lobectomy in these patients. iii. describe the complications associated with this procedure. iv. describe the length of the operative procedure, duration of chest tube stay, and length of hospitalization in this patient population. v. describe the survival and failure-free survival, over a 5-year period, in this patient population following this procedure. outline: patients undergo video-assisted thoracic surgery (vats) lobectomy, which requires 3 small incisions on the side of the chest. the entire anatomic pulmonary lobe is removed, as well as all peribronchial lymph nodes and anterior hilar lymph nodes. if it is not possible to remove the lobe using the vats approach, then 1 of the incisions is converted to a standard thoracotomy. patients are followed every 4 months for the first 2 years, and then every 6 months for the next 3 years. projected accrual: a total of 135 patients will be accrued for this study within 3 years.

Eligibility criteria:
disease characteristics: suspected or histologically documented non-small cell lung cancer solitary, peripheral lung lesion that is no greater than 3.0 cm no metastatic disease no positive lymph nodes at mediastinoscopy at least 5 years since diagnosis of non-small cell or small cell lung cancer patient characteristics: age: not specified performance status: ecog 0-2 life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified pulmonary: fev1 at least 1.0 l or at least 50% of predicted other: no significant comorbid medical or psychiatric condition no other active malignancy other than nonmelanomatous skin cancer prior concurrent therapy: not specified

Keywords: occult non-small cell lung cancer stage i non-small cell lung cancer stage 0 non-small cell lung cancer
hydrotherapy cp and lying down to sitting position

Conditions: Cerebral Palsy

Summary: the purpose of this study is to investigate the effect of a very specific hydrotherapy programm on the movement from lying down to sitting position for children with cp

40 children aged 5-11 years with cerebral palsy and difficulty in the transfer activity from lying down to sitting position were randomly divided into 2 groups of 20 children, a land group and a water group. the children of the land attended a neurodevelopmental treatment program and the water group a very specific program in hydrotherapy on combined rotation at all levels. the water program was implemented by specialized physiotherapists in hydrotherapy. the duration of the program for both groups was 3 months. on the first and last day of the intervention, an evaluation of all children was performed using the gmfm and pbs evaluation tests of the evaluation parameters of the transfer from the lying position to the sitting position.

Eligibility criteria:
inclusion criteria: * cerebral palsy * difficulties from lying down to sitting posistion exclusion criteria: * surgery or injection of botilium toxin in the last year. * scheduled surgery or injection of botilium toxin. * uncontrolled seizures. * do not run elementary commands or play a test representation. * autism. * syndromes without op. * serious vision problem. * absence from the treatment program for more than a week.

Keywords: cerebral palsy hydrotherapy neurodevelopmental treatment lying down sitting
the purpose of this study is to evaluate the effects of ruxolitinib cream on adults with atopic dermatitis experiencing sleep disturbance.

Conditions: Atopic Dermatitis

Summary: the purpose of the study is to evaluate the effect of ruxolitinib cream on sleep disturbances with participants with atopic dermatitis.


Eligibility criteria:
inclusion criteria: * has clinically confirmed diagnosis of active ad according to hanifin and rajka (1980) criteria. * has at least a 2-year history of ad (information obtained from medical chart, participant's physician, or directly from the participant). * has an overall bsa affected by ad of 3%-20% (excluding scalp) at the screening and baseline visits. * has an iga score ≥ 2 at the screening and baseline visits. * has an itch nrs score ≥ 4 at the screening and baseline visits. * willing to complete the once-daily itch nrs (24-hour recall period) entries at approximately the same time each day during the study. * agrees to maintain a regular sleep schedule during the study period. * willing and able to follow required study procedures for measuring sleep for the duration of the study. exclusion criteria: * currently using a wearable or other device for monitoring sleep patterns and unwilling to discontinue its use during the study. * currently has a schedule that includes nighttime work shifts. * has had significant flares or unstable course in ad (ie, condition worsened significantly or required significant change in medications, as per medical judgment) in the previous 4 weeks before screening (information obtained from medical chart, participant's physician, or directly from the participant). * has received any ultraviolet b phototherapy (including tanning beds) or excimer laser within 4 weeks prior to the screening period. * has had psoralen plus ultraviolet a treatment within 4 weeks prior to the screening period. * has received a nonbiological investigational product or device within 4 weeks prior to the screening period, or is currently enrolled in another investigational drug study. * has received treatment with jak inhibitors (systemic or topical) within 4 weeks prior to the screening period. * has had prior treatment with a jak inhibitor that was discontinued for safety reasons or tolerance problems. * has a known or suspected allergy to ruxolitinib or any component of the study drug.

Keywords: ruoltitinib atopic dermatitis sleep distubance itch opzelura
the illness of uncertainty, personality and coping strategies in patients with hepatocellular carcinoma

Conditions: Liver Carcinoma

Summary: the aims of this study are to (1) understand the uncertainty , personality and coping strategies in patients with hcc, and identify the significant factors for coping.

a cross-sectional correlated design will be used and (2) patients will be recruited by purposive sampling from wards and outpatient departments at a medical center in taipei.

Eligibility criteria:
inclusion criteria: * adult * has hcc and knows condition * con's clear * agree join the study exclusion criteria:e * bclc stage c or d * accepted c/t, r/t,target therapy or supportive care * patient who receive liver transplantation

Keywords: liver cancer uncertainty personality coping strategies
complex spine enhanced recovery after surgery (eras)

Conditions: Scoliosis Idiopathic

Summary: in the field of adult spinal deformity (asd), there are currently no standardized protocols for preoperative, intraoperative or post-operative care. new standards are being created for minimally invasive spine surgery within orthopedics and some neurosurgical centers. this study will evaluate the efficacy of an enhanced recovery after surgery protocol for complex spine surgery performed for the treatment of asd.

purpose : in the field of adult spinal deformity (asd), there are currently no standardized protocols for preoperative, intraoperative or post-operative care. new standards are being created for minimally invasive spine surgery within orthopedics and some neurosurgical centers. this study will evaluate the efficacy of an enhanced recovery after surgery protocol for complex spine surgery performed for the treatment of asd. participants : patients undergoing surgery aimed at treating adult spinal deformity are the subject of this research. this population was chosen as these procedures are often associated with prolonged length of stay (los), high post-operative narcotic use, and often require complex post-operative discharge planning. procedures : patients undergoing surgery to address the complications of asd present a unique challenge in that this patient population is diverse, and there are multiple operative procedures available to treat the same condition. given that there are currently no accepted or recommended enhanced recovery after surgery protocols for complex spine procedures, the investigators have developed an eras protocol at the university of north carolina (unc) in collaboration with the anesthesia department for the support of complex surgical patients. hypothesis: implementing a multi-modal enhanced recovery after complex spine surgery protocol will improve patient measured outcomes and patient functional outcomes leading to a statistically significant reduction in los, post-operative pain, complication rate, cost.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of the international statistical classification of diseases and related health problems (icd-10) scoliosis (m41.9) category. * patients undergoing a \> 5 level arthrodesis using one of the following current procedural terminology (cpt) coded procedures 22534, 22585, 22614, 22632, 22634 with either 22842, 22853 * cobb angle \> 10 degrees * failure of 3 months of conservative management exclusion criteria: * prior scoliosis surgery not performed at unc chapel hill hospital facilities * deformity correction due to trauma * history of neoplastic spine disease * patients with active osteomyelitis * patients with prior cement augmentation.
investigating the pharmacokinetic properties of nn1250 in healthy chinese subjects

Conditions: Diabetes; Healthy

Summary: this trial was conducted in asia. the aim of this trial was to investigate the pharmacokinetic properties (the effect of the investigated drug on the body) of nn1250 (insulin degludec) in healthy chinese subjects.


Eligibility criteria:
inclusion criteria: * male or female chinese subject aged 18-45 years (both inclusive) * considered generally healthy upon completion of medical history, physical examination, vital signs and electrocardiogram (ecg), as judged by the investigator * body mass index 19.0-24.0 kg/m\^2 (both inclusive) exclusion criteria: * a history of any illness that, in the opinion of the investigator, might confound the results of the trial or pose risk in administering the trial product to the subject * subject who has donated any blood or plasma in the past month or more than 400 ml within 3 months prior to screening * not able or willing to refrain from smoking during the inpatient period
video emergency calls of bystanders

Conditions: Audio-Emergency Call; Video-Emergency Call

Summary: emergency center dispatchers often face the challenge that emergency calls typically provide only verbal information. however, many first responders use smartphones, which could enable the option for video calls during emergencies. leveraging this technology could offer control center staff additional insights, potentially transforming the way they manage emergency situations. despite this, the impact of video emergency calls on call duration and user experience remains largely unexplored. in this project, 20 control center employees will undergo a one-hour training session on a video emergency call system. after the training, each dispatcher will handle four simulated emergency calls-two via audio and two via video. to facilitate this, 80 first responders will be recruited from public spaces, such as shopping centers. these responders will face simulated emergencies, including epileptic seizures, shortness of breath, forehead lacerations, or injuries to the upper extremities with minor bleeding. professional medical actors will simulate the emergencies, and the responders will be tasked with making either an audio or video emergency call.


Eligibility criteria:
inclusion criteria: * 18-70 years * user of a smartphone * german language exclusion criteria: * ems personnel
out of plane approach for interscalene

Conditions: Acute Pain; Brachial Plexus Block

Summary: study aims to examine the influence of out of plane interscalene approach to a brachial plexus block on the effect of phrenic nerve blockade.

studies have proven that there is 100% blockade of the phrenic nerve with the in-plane approach to the interscalene brachial plexus block. the patient population with pulmonary comorbidities with poor reserve cannot afford to have a further deterioration of their pulmonary status due to phrenic nerve blockade. these patients are not ideal candidates for increased opiate therapy for intraoperative and post-surgical pain as well due to further depression of their respiratory function. to optimize their pain control as well as avoid any respiratory-related morbidity and mortality, it is ideal to develop a technique which can provide appropriate brachial plexus block at the interscalene level while completely avoiding any local anesthetic spread to the phrenic nerve. the study aims to examine the influence of out of plane interscalene approach to a brachial plexus block on the effect of phrenic nerve blockade. practitioner preference and institutional norms often influence the in plane approach for the above-mentioned block. the most common practice at our institution is the in plane approach to the brachial plexus block.

Eligibility criteria:
inclusion criteria: * adult patients(18-85 years old) * scheduled for elective shoulder surgery who would benefit from a preoperative interscalene approach to the brachial plexus block for intraoperative and postoperative pain relief. exclusion criteria: * patients with any distorted anatomy for whom the block cannot be performed accurately, such as scars, surgical fixtures at the site, active infection, any open wound or drains at the site. * patients who request benzodiazepine anxiolytics such as midazolam for premedication before the procedure. also patients who request narcotic medications as premedication before the procedure * non-english and non-spanish speaking patients * inadequate or failed blocks and inadvertently intrathecal or intravascular injection will be dropped from the study * incarcerated patients * expected heavy bleeding on multiple anticoagulants with markedly elevated pt ( prothrombin time ), inr (international normalized ratio ), ptt ( partial thromboplastin time ) levels and markedly reduced platelet counts
study for which treatment, tadalafil or sildenafil, is preferred for problems getting or maintaining an erection

Conditions: Impotence

Summary: to determine if men prefer tadalafil or sildenafil for getting and keeping an erection after treatment with both drugs.


Eligibility criteria:
inclusion criteria: * history of erection problems * never taken treatments known as pde5 inhibitors for erection issues * abstain from using any other erection treatments during the study * anticipate a monogamous female sexual relationship * must be able to make required sexual intercourse attempts exclusion criteria: * history of other primary sexual disorder * treatment with nitrates * have a penile implant or clinically significant penile deformity * history of certain heart problems * do not meet certain lab value reference ranges