Kornimate/medical-research-clean huggingface dataset:
pipeline embolization for intracranial aneurysms

Conditions: Efficacy, Self; Hemodynamic Instability; Stenosis; Aneurysm, Intracranial

Summary: this study collected the clinical, laboratory, and imaging data from patients with intracranial aneurysms, who underwent pipeline implantation. the purpose of this study is to observe the safety, effcacy, and haemodynamics after pipeline embolization.

this study collected the clinical, laboratory, and imaging data from patients with intracranial aneurysms, who underwent pipeline implantation. the purpose of this study is to observe the safety, effcacy, and haemodynamics after pipeline embolization. the primary outcomes were aneurysmal occlusion status, incidence of in-stent stenosis, and functional prognosis. the secondary outcomes were hemodynamic changes before and after stent implantation.

Eligibility criteria:
inclusion criteria: 1. aged 22 to 75 years old, male or non-pregnant female; 2. uia was diagnosed by cta, mra, or dsa; 3. the size of aneurysms is between 3 to 25mm; 4. understands the nature of the procedure and provision of written informed consent; 5. indications for fd implantation with or without adjunctive coiling; 6. is willing to return to the investigational site for follow-up according to our protocol. exclusion criteria: 1. with contraindications to flow-diversion treatment or known allergy to cobalt-chromium alloy or contrast medium; 2. pregnancy or lactation; 3. coexist with other vascular lesions (coronary artery disease, abdominal aortic aneurysm, severe intracranial artery stenosis, arteriovenous malformation, dural arteriovenous fistula, moyamoya disease, etc.); 4. parent vessel with a diameter \<2.0 mm or ≥5.0 mm.; 5. unwilling to be followed up or likely to have poor treatment compliance; 6. life expectancy less than 3 years; 7. inability to receive anti-platelet or anticoagulant medication; 8. severe neurological deficit that renders the patient unable to live independently (modified rankin score ≥4); 9. enrollment in another trial or other situations that the researcher deems unsuitable for inclusion in the study.

Keywords: intracranial aneurysms flow-diverter device pipeline embolization device in-stent stenosis
evaluation of professional practices in the treatment of refractory idiopathic overactive bladder at the dose of 50 units (tox50iuu)

Conditions: Bladder, Overactive

Summary: considering that the 2013 hermieu's guidelines differs from the product marketing authorization delivered in november 2014, the primary endpoints is to evaluate life quality by questionnaires at the baseline time, and after two, six and twelve weeks of treatment in patients suffer from urinary incontinence by refractory idiopathic overactive bladder and treated by botox® at the dose of 50ui (international units)

currently, botox injection is one of the second-line treatments for urinary incontinence by idiopathic overactive bladder. multiple studies have shown that botox at the dose of 50ui is effective but not for a long time. maximum efficiency is about two weeks and until about twelve weeks compared to the dose between 100ui and 300ui that shown an efficiency until twenty-four at thirty-six weeks. but it's not without consequence since the side effects are more numerous increasing the dose. the most frequent are urinary retention with necessary to perform clean intermittent catheterization and urinary infection. this dose at 50ui is therefore more a test to assess the patient's tolerance to the product, as recommended by the product marketing authorization. so, through this evaluation of professional practices, investigators would like to evaluate the patient satisfaction treated in hospital, with a first dose at 50ui.

Eligibility criteria:
inclusion criteria: * female * age ≥ 18 yo * refractory idiopathic overactive bladder * eligibility to an injection treatment * capacity to perform clean intermittent catheterization exclusion criteria: * protected adults (under trusteeship, guardianship or judicial protection) * patients under anticholinergics for an other desease (psychiatric, neurologic for example) * known hypersensitivity or at risk of hypersensitivity to botulinum toxin type a like myasthenic syndrom * patients who suffer from an overactive bladder with a known cause (neurological, urological condition) * urinary infection under treatment \< 48 hours before botox® injections * suspicious looking bladder requiring biopsies during the cystoscopy * pregnant or breastfeeding women * language barriers

Keywords: idiopathic overactive bladder botox onabotulinum toxina 50 units
effects of vasopressor on the graft blood flow in tram

Conditions: Blood Flow; Anastomotic Failure of Flap; Flap Necrosis; Flap Ischemia

Summary: the purpose of this pilot study is to investigate whether two major vasopressors (norepinephrine vs. phenylephrine) used for treatment of hypotension during breast reconstruction with free flap transfer surgery have different effects on blood flow of the flap vessel measured by transit time flowmetry. since there are few prior studies that compared the effects of these two vasopressors on the blood flow of the flap, this study will be conducted in the form of a pilot study in order to establish the evidence for the future randomized controlled trial.


Eligibility criteria:
inclusion criteria: * asa physical status classification grade 1-3 * patients with an ecog score of 0 or 1 when selecting a subject for the study * patients who can provide written consent to participate in clinical trials * patients requiring the use of vasopressor because the mean arterial pressure is not maintained more than 65 mmhg during surgery exclusion criteria: * patients with peripheral arterial diseases * patients with allergic history to study drugs * if surgery on other areas is scheduled at the same time or is an emergency operation * patients with history of previous abdominal surgery involving the flap donor site * pregnant * if there are other major medical or psychiatric disorders that may affect treatment response * left ventricular ejection fraction \< 30% or with a history of arrhythmia that is not controlled by medication * refuse to participate

Keywords: blood flow failure of flap vasopressor phenylephrine norepinephrine
the rubber hand illusion (rhi) in patients with crps

Conditions: CRPS; Unilateral Limb Pain of Origin Other Than CRPS

Summary: the present study investigates by means of the rubber hand illusion body image stability and sense of body ownership in patients with crps of the upper limb compared to patients with unilateral pain of origin other than crps and age and sex-matched healthy subjects.

in patients with crps of the upper limb distortions of body representation and impairments of sense of body ownership are well-known. to investigate the body schema and body image stability of these patients in comparison to patients with upper limb pain of origin other than crps and healthy subjects, we conducted a series of rubber hand illusions. this well - established paradigm is elicited by visuo-tactile stimulation of one´s own real hand and a visible hand and forearm prosthesis. the present study investigates 1) if and how far patients with crps are susceptible to experience the illusion 2) how far the illusion strength differs between crps and patients with unilateral pain of the upper limb of other origin and healthy subjects 3) how far parameters, e.g. neglect-like severity symptoms, body plasticity, empathy, duration of disease and pain intensity influence the illusion strength.

Eligibility criteria:
inclusion criteria: every participant: * aged \> 18 years * written informed consent * free to withdraw participation at any time * adequate understanding of the german language patients with crps: * patients with crps type 1 of the upper limb * clinical symptoms were diagnosed on the basis of the recently modified diagnostic research criteria (harden, bruehl et al., 2007) * proved by typical enhancement in the late phase of the 99m-technetium-triple-phase bone skeleton scintigraphy (wüppenhorst, maier et al., 2010) patients with unilateral pain of the upper limb: * unilateral pain * pain of origin other than crps healthy subjects: * age and sex matched to patients with crps * checked by the dfns imi questionnaire exclusion criteria: every participant: * inadequate understanding of the german language * missing informed consent * diabetes mellitus patients with crps: -crps type 2

Keywords: rubber hand illusion crps body image body ownership
the fibregum study - changing the course of obesity in children

Conditions: Nutritional and Metabolic Diseases; Child Obesity; Adolescent Obesity

Summary: the aim of this study is thus to assess the effect of a chewing gum containing fibres on body weight, metabolism and the oral and intestinal microbiomes in a population of obese children.


Eligibility criteria:
inclusion criteria: * informed consent according to international conference on harmonisation of technical requirements for registration of pharmaceuticals for human use/good clinical practice (ich/gcp) regulations prior to any study specific procedures * obesity as determined by a bmi ≥97th percentile using the swiss paediatric, age- and sex-matched growth charts * newly referred within the last month to a tertiary weight management clinic * participant willing to use the study specific monitoring app on his/her own or legal representatives' smartphone exclusion criteria: * antibiotic administration in the last 6 months * pre- or probiotic treatment in the last 6 weeks * any professionally supervised treatment for weight management within the last year * consumption of more than one nicotine product per month (e.g. cigarette, gum) * adolescent females: any stages of known pregnancy or lactation period * congenital disorder affecting the cardiovascular, hepatic or respiratory system in a relevant way (as per pi's or specialist's evaluation) * malignant disease on treatment or previous tumour affecting the appetite system (e.g., suprasellar, hypothalamic tumours) * systemic antibiotic or anti-inflammatory medication (e.g. systemic intake of glucocorticoids) over the last 7 days * known eating disorder (medically diagnosed) * participation in another investigation with an investigational drug within the 30 days preceding and during the present investigation * dependency from the sponsor or the clinical investigator * inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, etc. of the participant and/or legal representative

Keywords: obesity chewing gum galactooligosaccharides gos (galactooligosaccharides)
transcranial direct current stimulation on cortical plasticity in patients with anti-nmda receptor encephalitis

Conditions: Anti-NMDA Receptor Encephalitis

Summary: patients suffering from anti-nmda receptor encephalitis show impaired nmda-receptor dependent neuronal transmission. furthermore, they often have cognitive deficits of different magnitude. impaired neuronal signaling of nmda-receptors very likely result in decreased cortical synaptic plasticity. thus, this represents one major reason of cognitive deficits. synaptic plasticity can be assessed in humans via the non-invasive technique of transcranial magnetic stimulation (tms). the current study aims to investigate whether learning ability and also cortical plasticity can be changed by applying sessions of transcranial direct current stimulation (tdcs). therefore, we are recruiting 10 to 15 patients suffering from anti-nmda receptor encephalitis as well as healthy controls in order to compare tdcs effects. learning ability is assessed by motor sequence tasks, whereas cortical plasticity is measured via tms. tdcs is a novel non-invasive technique allowing induction of changes in cerebral excitability level and also cortical plasticity. previous studies showed positive outcome of anodal stimulation on learning tasks. especially motor learning seems to be an important target for tdcs treatment since it showed best results for both post-stroke patients and healthy subjects. multiple sessions of tdcs are inducing long-term effects and improved learning function, which were present three months after stimulation. in this study we hope to reveals new insights into the pathomechanisms of impaired cognitive and learning abilities in patients having anti-nmda receptor encephalitis. moreover, we evaluate whether tdcs is an effective treatment for patients with cognitive and learning deficits.


Eligibility criteria:
inclusion criteria: * patients suffering from anti-nmda receptor encephalitis * healthy (control) subjects exclusion criteria: * any metal inside the body/head, e.g. clips, pace maker, medical pumps, cochlear implant etc. * traumatic brain injury * stroke * cerebral tumor * pregnancy * untreated severe internal or psychiatric diseases
harmonic vs hf knife in patients requiring abdominal surgery

Conditions: ABDOMINAL SUBCUTANEOUS FAT

Summary: prospective, non-randomized, controlled study to investigate the clinical outcome of surgery using the harmonic knife vs the hf knife in patients requiring abdominoplastic surgery or body lift (lockwood)

aim of the study is to measure amount of seroma in each interventional arm.

Eligibility criteria:
inclusion criteria: * 18 years * willing to give consent * indication for abdominoplastic surgery * no contraindication for general anaesthesia exclusion criteria: * smoking more than 10 p/day * diabetes mellitus i or ii * known neoplasms * not willing or able to conform with study requirements
a survey of recombinant adamts13 in participants with congenital thrombotic thrombocytopenic purpura

Conditions: Thrombotic Thrombocytopenic Purpura (TTP)

Summary: this study is a survey in japan of recombinant adamts13 used to treat or to prevent participants with congenital thrombotic thrombocytopenic purpura (cttp). the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. the main aim of the study is to check for side effects related from recombinant adamts13 and to check if recombinant adamts13 improves or prevents cttp. during the study, participants with cttp will take recombinant adamts13 intravenous injection according to their clinic's standard practice. the study doctors will check for side effects from recombinant adamts13 for 18 months.


Eligibility criteria:
inclusion criteria: - all participants with congenital thrombotic thrombocytopenic purpura (cttp), treated with recombinant adamts13 exclusion criteria: - none
effect of donepezil on the reorganization of cognitive neural network in patients with post-stroke cognitive impairment

Conditions: Stroke

Summary: the purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.


Eligibility criteria:
inclusion criteria: * ischemic stroke in the territory of right or left middle cerebral artery * post-onset duration of the recent-onset stroke is over 3 months * cognitive deficit ranged from 10 to 26 by minimal mental status examination (mmse) score * disturbance in activities of daily living (adl) ranged 0.5 \~ 2.0 by clinical dementia rating (cdr) scale exclusion criteria: * severe internal carotid artery stenosis on the lesion side * cardiac pacemaker or intracranial metal insertion * post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (eeg)

Keywords: donepezil stroke cognitive function cognitive neural network
igrow readers nutrition and physical activity curriculum efficacy

Conditions: Pediatric Obesity; Knowledge, Attitudes, Practice; Physical Activity; Diet Modification

Summary: the objective of this study was to determine the efficacy of the igrow readers curriculum in changing diet and physical activity knowledge among preschool-aged children. the secondary objective of this study was to better understand the relationship between diet and physical activity related outcome variables in preschool aged children and their primary caregivers.

the objective of this study was to determine the efficacy of the igrow readers curriculum in changing diet and physical activity knowledge among preschool-aged children. the secondary objective of this study was to better understand the relationship between diet and physical activity related outcome variables in preschool aged children and their primary caregivers. igrow readers was created to support literacy development among preschoolers, while promoting nutrition and physical activity messages. this program utilizes the social cognitive theory because it focuses on different environments influencing individual's behaviors and knowledge acquisitions, primarily through observing others within the context of social interactions and experiences. developmentally appropriate preschool-aged children books, including relevant native american books, facilitate the themes of healthy physical activity and nutrition practices. the program, a 6-8-week educational curriculum, helps young children understand the benefits of making healthy decisions involving nutrition and physical activity.

Eligibility criteria:
inclusion criteria: 3-5 year old children attending a participating early childhood care facility. all early childhood care facilities had at least two classrooms available. all children provided assent and their participating guardian provided consent. exclusion criteria:

Keywords: obesity physical activity nutrition curriculum preschool literacy
pooled red blood cells prepared from pooling 5 leukoreduced, irradiated rbc units

Conditions: Transfusion Reaction; Anemia

Summary: the purpose of the study is to determine the safety of pooled red blood cells (rbcs) compared to standard leukoreduced rbc products stored in additive solution. the primary objective is to determine if there is no significant difference in transfusion associated adverse events in pooled-rbcs compared to standard rbc product groups. secondarily to determine if there are no significant differences in new antibody and new positive direct antiglobulin test (dat) formation in the pooled-rbcs compared to standard rbc product groups.

this research study is enrolling subjects who are receiving rbc (red blood cell) blood transfusions as part of their treatment. in this study, we are testing a new way of preparing rbc units (pooled rbc units) for transfusion compared to the standard rbc units. we are testing this because blood transfusions may be associated with side effects that may be harmful. we have developed a new way to process rbc for transfusion to try and reduce some of those side effects. the pooled rbc units will be made by sterilely pooling five (5) single rbc units into one container where the blood will be mixed together, and then separated into five individual rbc units, ready to be used for transfusion. the purpose of the study is to determine the safety of the blood prepared in this new way compared to standard rbc products. the primary objective is to determine if there is no significant difference in transfusion associated adverse events in pooled-rbcs compared to standard rbc product groups. secondarily to determine if there are no significant differences in new antibody and new positive direct antiglobulin test (dat) formation in the pooled-rbcs compared to standard rbc product groups.

Eligibility criteria:
inclusion criteria: * age\>= 18 years * hematology/ oncology or other chronic transfusion dependent patients * patients who are in need of transfusion due to low hemoglobin level (\<8 gm/dl) * patients who only require one or two transfusion episode of 1-2 rbc units each during 60 day period * currently not planning to be pregnant during the study period exclusion criteria: * previously identified alloantibodies (other than to d, c, e and k) * positive direct antiglobulin test, currently or within the last year * emergency transfusion * patients \< 18 years old * need for specialized products, such as washed * patients involved in other rbc transfusion clinical trial * currently or planning to be pregnant within the proposed study period
role of comorbidities in chronic heart failure study

Conditions: Heart Failure; Comorbidity; Osteoporosis; Pulse Wave Analysis; Blood Pressure Monitoring, Ambulatory; Osteoporotic Fractures

Summary: this study aims to create a database of patients with stable and chronic heart failure with comprehensive assessment of bone, skeletal and vascular status. roc-hf will facilitate cross-sectional and, eventually, longitudinal mechanistic epidemiological analyses to disentangle the role of the bone- vascular axis in chronic heart failure. blood and urine samples will be stored to facilitate future biomarker analyses.


Eligibility criteria:
inclusion criteria: 1. age \>= 18 2. nyha (new york heart association) class ii-iv symptoms 3. left ventricular ejection fraction \< 50% at visit 1. 4. treatment according to current heart failure guidelines of the european society of cardiology 5. willingness and ability to provide signed informed consent form (icf) prior to participation in any study-related procedures 6. previous diagnosis of heart failure with reduced ejection fraction defined as symptomatic left ventricular ejection \< 40% requiring optimization of heart failure therapy exclusion criteria: 1. unplanned hospitalization within 1 month prior to the baseline visit. 2. discontinuation or initiation of a pharmacologic or device treatment for hfref within 1 month prior to the baseline visit. 3. coronary or peripheral revascularization procedures, valvular procedures, or any major surgical procedure within 3 months prior to the screening visit. 4. acute coronary syndrome (acs), stroke or transient ischemic attack (tia) within 3 months prior to the screening visit. 5. any acute illness 6. disease reducing life expectancy to \< 1 year, except hfref 7. recipient of any organ transplant 8. primary significant valve disease (at least moderate to severe valve disease)
hyoscine butylbromide for prevention of bradycardia during cesarean section

Conditions: Bradycardia; Spinal Anesthetics Causing Adverse Effects in Therapeutic Use; Cesarean Section Complications

Summary: the aim of this study is to assess the efficacy of iv hyoscine butylbromide in preventing bradycardia during cesarean section under spinal anaesthesia with local anaesthetic and morphine.


Eligibility criteria:
inclusion criteria: * asa physical status class i-ii. * age: 18 years to 40 years. * women scheduled for elective cesarean section under spinal anesthesia. * indications for cs other than fetal or maternal pathology. exclusion criteria: * height \ 180 cm * body mass index (bmi) \>35 kg/m2 * contraindication for central neuraxial block * refusal to undergo regional anesthesia * known allergy to any of the study drugs, * infection at the site of injection, * coagulopathy, * indication to general anesthesia * baseline bradycardia (heart rate \< 60/min), or any cardiovascular disease * patients taking β-adrenergic blockers or any drugs that may alter normal response to study drugs. * arrhythmia such as atrial fibrillation, supraventricular tachycardia, heart block greater than first degree, left bundle branch block, * hypertension (systolic blood pressure more than 140 mm hg or diastolic blood pressure more than 90 mm hg), unstable angina or cardiomyopathy, * associated medical problem with pregnancy (as hypertension, diabetes mellitus, hepatic impairment or renal impairment)