Kornimate/medical-research-clean huggingface dataset:
impact of malnutrition on the healing of foot lesions in diabetic patients

Conditions: Patients With Type 1 or 2 Diabetes; Lesion Situated on a Toe or on the Plantar or Dorsal Side of the Foot

Summary: the investigators set out to determine whether malnutrition delayed healing of foot lesions in diabetic patients.


Eligibility criteria:
inclusion criteria: * patients who have provided oral consent * patients older than 18 * patients with type 1 or 2 diabetes * patients who can be followed-up in the context of consultations for diabetic foot at the endocrinology, diabetology and metabolic diseases unit of dijon chu. * lesion situated on a toe or on the plantar or dorsal side of the foot * lesion that has evolved for 1 to 24 months exclusion criteria: * adult under guardianship * patient without national health insurance * pregnant or breast-feeding women * patients with progressive cancer * patients with terminal renal insufficiency on dialysis * patient with severe respiratory insufficiency * patients with terminal heart failure * patients with severe liver failure * patients with immunodepriession (treatement with immunosuppressants, long-term corticotherapy, diseases leading to immunodepression) * patients with nephrotic syndrome (hypoalbuminemia) * patientswith a chronic inflammatory syndrome * alcohol consumption greater than 4 glasses per day * systemic infection uncontrolled by antibiotics * infected lesion with systemic repercussions * charcot foot * patients taking part or who have planned to take part in another clinical trial * severe disease affecting survival in the short term * lesion on an amputation * lesion of the ankle or leg
treatment of intimate partner violence and substance abuse in a forensic setting

Conditions: Domestic Violence; Substance Abuse

Summary: intimate partner violence is a significant societal problem. however, treatment of ipv perpetrators is far from effective, which may be partly due to the fact that the role of substance abuse is not taken into account. there is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists. besides, a few studies indicate that reducing substance use may have a positive impact on ipv. therefore, in this study, perpetrators of intimate partner violence with substance use disorders enrolled in domestic violence treatment will be randomly assigned to either standard treatment for offenders of domestic violence or a combination of the latter treatment with cognitive-behavioral therapy addressing substance abuse (combined treatment).


Eligibility criteria:
inclusion criteria: * a history of perpetration of intimate partner violence * current alcohol, cannabis and/or cocaine abuse or dependence * still in an intimate relationship with the victim exclusion criteria: * not sufficient fluency in dutch to complete treatment and measures * (ab)use of crack cocaine and/or heroin * in need of clinical detoxification * severe mental disorders, such as psychosis * severe cognitive disorders, such as korsakoff's syndrome * in treatment for other mental health problems * abuse of children

Keywords: intimate partner violence domestic violence substance abuse alcohol abuse drug abuse addiction
measurement of core temperatures during therapeutic hypothermia

Conditions: Cardiac Arrest

Summary: the purpose of this study is to determine that the measurements of rectal and bladder temperature are correctly consistent with core temperature by using the pulmonary artery catheter during therapeutic hypothermia; rapid cooling, maintenance, and slow rewarming phase.

the guidelines of therapeutic hypothermia(th)are rapid cooling, from normothermia to mild hypothermia(32\~34 degree), maintenance, and slow rewarming phase. if core temperature maintained below 32 degree during th, som complications will be developed, such as arrythmia, hypotension, cold diuresis, coagulopathy, and so on. therefore correct measurement of core temperature during th is very important process for successful post cardiac arrest care. we will know that rectal or bladder temperature are really reflect the core temperature during th for post cardiac arrest care, especially rapid cooling phase, maintenance phase, and slow rewarming phase, respectively.

Eligibility criteria:
inclusion criteria: * out of cardiac arrest patient who is 18 years old. * mean arterial pressure must be over 65 mmhg after return of spontaneous circulation. * family consent to this study. exclusion criteria: * in hospital arrest. * arrest due to trauma * arrest due to intracranial hemorrhage. * below 30 degree at initial core temperature. * pregnancy. * family do not agree with our study. * active bleeding patient.

Keywords: resuscitation, hypothermia
the efficacy and safety of dabigatran etexilate for the treatment of cerebral venous thrombosis

Conditions: Cerebral Venous Thrombosis

Summary: this is a single-center, prospective, randomized (1:1), open-label study with two parallel groups. this study is planned to investigate the efficacy and safety of dabigatran etexilate comparing with warfarin for the treatment of cerebral venous thrombosis.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cerebral venous thrombosis (cvt), with or without intracranial haemorrhage. * patients in the acute or sub-acute phase of cvt. * completion of anticoagulation therapy for 5-15 days which has been administered until randomization; anticoagulation must include full-dose low molecular weight heparin or unfractionated heparin. * eligibility for treatment with an oral anticoagulant. * written informed consent. exclusion criteria: * cerebral venous thrombosis (cvt) associated with central nervous system infection or due to head trauma. * thrombosed venous sinuses showed completely recanalized by mrv before randomisation. * planned endovascular treatment for cvt or surgical treatment for other diseases. * conditions associated with increased risk of bleeding. * history of symptomatic non-traumatic intracranial haemorrhage with increased risk of recurrence according to investigator's judgment. * treatment with an antithrombotic regimen for an indication other than cvt and requiring continuation of that treatment for the original diagnosis. * severe renal impairment(crcl\<30ml/min). * active liver disease (alt≥ twice the upper limit of normal). * preganancy, nursing or planning to become pregnant during the trial.
efficacy of low dose promethazine for postoperative nausea and vomiting

Conditions: Ambulatory Gynecological Laparoscopic Procedures

Summary: there has been an increase in ambulatory surgical procedures performed across canada; ambulatory procedures account for almost 70% of all surgeries. postoperative nausea and vomiting (ponv) and pain are the most frequently reported adverse events by patients prior to discharge after ambulatory surgery. the incidence can be as high as 70 to 80% in high-risk patients. ponv is a cause of morbidity particularly in gynecological procedures and the incidence of patients experiencing ponv is as high as 58-75%. apart from delayed recovery, the occurrence of ponv has been linked to gastric aspiration, psychological distress and wound dehiscence. the occurrence of ponv delays patient discharge and further more is a leading cause of unexpected admission after ambulatory anesthesia promethazine, is an antiemetic medication that has been widely used over the last 50 years, and although effective at reducing ponv, it tends to cause sedation. in this study, we are trying to determine if a smaller dose of promethazine, in addition to the standard treatment for post-surgical nausea and vomiting, will be more beneficial than the standard treatment on its own. it is hypothesized that the use of low dose promethazine (3 mg) as part of a multimodal antiemetic regimen will be efficacious in preventing ponv without the sedative effects of promethazine.


Eligibility criteria:
inclusion criteria: 1. patient is between 18 - 60 yrs of age 2 patient's health is graded as class i-iii according to the american society of anesthesiologists physical status classification. 3. the patient has 2 or more of the following risk factors: * female * non-smoker * history of ponv/motion sickness * use of post-operative opioids (current surgery) 4. undergoing ambulatory gynecological laparoscopic procedures of at least 30 minutes duration exclusion criteria: * preexisting nausea, vomiting or retching, gastric outlet or intestinal obstruction * clinical evidence of a difficult airway * obesity (body mass index \> 40 kg m-2) * scheduled to receive propofol for anesthesia maintenance * current pregnancy * psychiatric illness * clinically significant major organic disease * preoperative qtc interval \> 440 ms on electrocardiogram * known hypersensitivity to promethazine, granisetron, ondansetron or other 5 ht3-receptor antagonists
mastery, social support and depression of patients with major depression

Conditions: Depression

Summary: the purpose of this study was to discuss the relation of mastery, social support and depression in patients with depressive disorder. cross-sectional quantitive study and purposive sampling method were designed. data collection and analysis was conducted through structural questionnaires (including demographics, social support scale, mastery scale, cesd scale) at a medical center in taipei. results showed that patients with depression whose degree of depression was negative correlated with mastery and social support, and mastery was positive correlated with social support. regression statistics results showed that mastery, social support, age, loss of jobs can predict degree of depression up to 60 percent. the mastery was strongest independent predictable factor to degree of depression, and had partial or total mediate effects to age, loss of jobs, financial condition, and social support. the result of this study suggested that clinically the care of patients with depression should focus on their confidence in mastery and provide strategies to promote their confidence in mastery, which can effectively reduce the degree of depression of those patients.


Eligibility criteria:
inclusion criteria: * patients with depression exclusion criteria: -
effects of tai chi for early pulmonary rehabilitation in elderly patients with aecopd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the goal of this clinical trial is to learn about the therapeutic effect of chinese traditional exercise tai chi in elderly acute exacerbation of chronic obstructive pulmonary disease (aecopd) with malnutrition. the main questions it aims to answer are: 1. improvement of pulmonary function in patients with tai chi exercise; 2. improvement of pulmonary function in patients with tai chi exercise. the patients in control group were given routine nursing care model, including: 1. providing basic nursing care and protection for patients according to their needs, paying attention to the care of patients' airways, and providing relevant protection and auxiliary interventions according to the needs of patients when carrying out nebulized inhalation interventions; 2. customized nutritional supplementation recipes by specialists in clinical nutrition, giving high-protein and low-carbohydrate diets, and giving enteral or parenteral nutritional support to those who have insufficient food intake through the mouth; 3. carrying out health education and psychological care to alleviate the patients' psychological burdens. on the basis of the routine care model of the control group, a tai chi training program was developed in tai chi group. tai chi training lasted for a total of 6 months, with 4 training sessions scheduled per week, each session lasting about 40 minutes. experts from anqing tai chi association were invited to guide the training. the training program consists of a 5-minute pre-training warm-up, a 30-minute tai chi exercise, and a 5-minute post-training stretching session. the tai chi training was done at a moderate intensity, with the heart rate limited to 60%\~80% of the maximal heart rate, where: maximal heart rate=220-age. accelerometers were worn for each member to record heart rate changes during training, and when the heart rate exceeded the standard range, the exercise intensity could be adjusted to keep the heart rate within a reasonable range.


Eligibility criteria:
inclusion criteria: 1. ≥60 and ≤85 years of age; 2. clinical diagnosis of copd according to the global initiative for chronic obstructive lung disease (gold) criteria; 3. patients admitted to the hospital for treatment of chronic, repetitive coughing and severe dyspnea; 4. nrs-2002 nutritional risk screening scale score ≧3, suggesting malnutrition; 5. conscious, able to perform normal verbal communication and without motor dysfunction exclusion criteria: 1. people with impaired consciousness or invasive mechanical ventilation who were unable to fully understand and cooperate with the experiment; 2. people with active tuberculosis, lung cancer, asthma and other diseases limiting ventilation; 3. people with impaired motor function; 4. people with serious life-threatening diseases of other systems and malignant tumors; 5. people with heart failure (nyha stage iv).
the mom to be study

Conditions: Infertility, Female

Summary: this research study is about the effects of diet and exercise in women undergoing fertility treatment.

this study will randomize women who are undergoing fertility treatment and put them either in an intervention group or standard care. this study should help us learn if diet and exercise changes oocytes gene expression and follicular fluid content.

Eligibility criteria:
inclusion criteria: * bmi 25 - 45 kg/m2 * ≥ 21 years of age exclusion criteria: * pre-existing conditions (e.g. sexual transmitted diseases) that will affect the outcomes of the study as determined by the principal investigator * current use of recreational drugs, tobacco, or alcohol * food allergies, intolerances or preferences which would interfere with compliance to the meal plan * contraindications to exercise * already meeting the physical activity guidelines (150 min moderate activity/week or 75 minutes of vigorous activity/week with resistance exercise on 2 or more days/week).
cancer survivors acute exercise response 1

Conditions: Neoplasms Malignant

Summary: the aims of this study examine the immune system, muscle metabolism, and autonomic nervous system response to an acute bout of exercise. cancer survivors will participate in an acute bout of exercise. blood samples will be collected before the exercise bout and at two time points after the exercise bout to assess the proposed variables.


Eligibility criteria:
inclusion criteria: * between the ages of 40-70 years * at least two years past detectible cancer (two years disease-free survival) * have received chemotherapy and/or radiation as part of their cancer treatment * all cancers were of the organs/non-blood producing tissues (not blood/hematologic cancers) and while they were an adult (no history of pediatric cancer) * meeting acsm-aha guidelines for exercise (150 minutes per week of cardiorespiratory fitness type exercises and \~two days per week of resistance training), as confirmed by a combination of a physical activity questionnaire and a cardiorespiratory fitness classification of "good" or higher (age and sex matched) * a bmi between 20-33 kg·m-2 * able to speak and read english exclusion criteria: participants may not: * have any contraindications to moderate to vigorous exercise * have any recent illness or have been instructed not to exercise by a healthcare provider * participants may not have range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory) * be taking medications (prescription or over the counter) known to influence immune function (including daily nsaid's and beta blockers), cholesterol-lowering medications (statins), drugs that increase bone mass (bisphosphonates), or steroids. * have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting bp below 140/90) and/or controlled asthma (self-reported). * be pregnant * be unable to complete all visits (i.e. must not be planning to leave the houston area long-term before concluding their participation in the study) * fall outside of a bmi range of (20 - 33) * consume alcohol or recreational drugs for 24h prior to visits * participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 2-3 times over the course of the study
feasibility study of the vedera kxs for treatment of keratoconus

Conditions: Keratoconus

Summary: the objective of this investigation is to evaluate the feasibility, safety and efficacy of the vedera kxs for the reduction or elimination of myopia and astigmatism in patients with keratoconus, who are no longer able to achieve adequate vision with their contact lenses or glasses.


Eligibility criteria:
inclusion criteria: 1. 14 years of age or older 2. presence of central or inferior steepening on the pentacam map 3. axial topography consistent with keratoconus 4. i-s ratio \> 1.5 on the pentacam map or topography map 5. bscva worse than 20/20 (\<53 letters on etdrs chart) 6. contact lens wearers only: removal of contact lenses for the required period of time prior to the screening refraction 7. signed written informed consent 8. willingness and ability to comply with schedule for follow-up visits exclusion criteria: 1. eyes classified as either normal or atypical normal on the keratoconus severity grading scheme. 2. a history of previous corneal surgery or the insertion of intacs in the eye(s) to be treated. 3. corneal pachymetry \<400 microns at diameter to be treated. 4. previous ocular condition (other than refractive error) in the eye(s) to be treated that may predispose the eye for future complications, for example: 1. history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, corneal melt, corneal dystrophy, etc.) 2. clinically significant corneal scarring in the treatment zone that is not related to keratoconus or, in the investigator's opinion, will interfere with the treatment. 5. a history of chemical injury or delayed epithelial healing in the eye(s) to be treated. 6. diagnosed with autoimmune disease, systemic connective tissue diseases or atopic syndrome, diabetes mellitus, or taking systemic medications likely to affect wound healing. 7. women who are pregnant or nursing or who plan to become pregnant over the course of their participation in this investigation.
breathing-maneuver-induced myocardial oxygenation reserve validated by ffr (b-more)

Conditions: Coronary Artery Stenosis

Summary: the study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.

this observational applied research international study aims to assess the validity of breathing maneuvers as a vasoactive maneuver and oxygenation-sensitive cardiac magnetic resonance imaging (os-cmr) in a patient population. os-cmr results will be compared to the clinical gold standard of fractional flow reserve (ffr) and instant wave-free ratio (ifr) as a secondary objective, to determine if this non-invasive, no pharmaceutical agent imaging technique can identify areas of oxygenation deficit in myocardium perfused by a stenosed coronary artery.

Eligibility criteria:
inclusion criteria: healthy participants * age: \> 40y * no known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system. cad patients * age \> 18 y * indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography. exclusion criteria: all participants: * general mri contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. * consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam. * regular nicotine consumption during the last 6 months. patients only * vasoactive medication (e.g. nitro) during the 12 hours prior to the exam contraindications to adenosine (2nd or 3rd a-v block, sinus node disease, asthma, bronchoconstrictive diseases). * acute coronary syndrome (acs), or previous coronary artery bypass surgery * previous myocardial infarction within 1 month * clinically unstable condition * significant or uncontrolled arrhythmia
vancomycin for c difficile naat+/eia- hematology oncology patients

Conditions: Clostridium Difficile Infection; Hematologic Diseases; Bone Marrow Transplant; Oncologic Disorders

Summary: this study will randomized hematology oncology patients with active diarrhea and a naat positive/toxin eia negative to either 14 days of oral vancomycin capsules or placebo. the study is designed to include 30 patients (15 per arm). outcomes will include c. difficile load using qpcr, vre loads, structural and functional microbiome changes and frequency of bowel movements. all endpoints will be measured at several time points including days 0, 14, 21 and 90.

the adverse health consequences resulting from antibiotic overtreatment of naat(+), toxin(-) patients may be particularly important in transplant recipients. the usual treatment prescribed for cdi at the froedtert memorial lutheran hospital is oral vancomycin. while this drug has excellent activity against c. difficile and commonly suppresses its growth to non-detection, it does not eradicate carriage and its use results in marked and prolonged disruption of the lower intestinal microbiota. meanwhile, the degree of lower intestinal microbiota disruption at the time of hsct engraftment has been demonstrated to be an independent predictor (controlling for other markers of underlying disease) of overall and transplant-related 3-year mortality.14 in addition, recent findings suggest that bone marrow suppressive effects of antibiotics, in this case potentially unnecessary oral vancomycin (which is not appreciably absorbed), may be solely mediated via microbiota disruption. all these data supports the notion that antibiotic treatment of naat(+), toxin(-) c. difficile patients might have significant negative repercussions without a clear clinical benefit.

Eligibility criteria:
inclusion criteria: * patients admitted to the hematology oncology inpatient units at froedtert memorial lutheran hospital * new onset of diarrhea during hospitalization * c. difficile clinical testing showing naat positive eia negative results exclusion criteria: * being unable to consent for self * inability to take enteral medications * unwillingness to enroll in study * patient has a documented allergy to vancomycin * patient has a documented life expectancy shorter than treatment course (14 days) * patient is unwilling or unable to provide stool samples in the outpatient setting after discharge * diagnosis of c. difficile colitis \[naat (+) and toxin eia (+) within 3 months of enrollment). * new onset of abdominal distention within 24 hours prior to the onset of diarrhea during index admission * presence of toxic megacolon * presence of clinical sepsis. sepsis will be defined as a sequential \[sepsis-related\] organ failure assessment (sofa) score of 2 points or more as per 2016 definitions * pregnancy or lactating

Keywords: microbiome bone marrow transplantation clostridium difficile metabolomics vancomycin