Kornimate/medical-research-clean huggingface dataset:
biomarkers and functional imaging in predicting response of esophageal cancer

Conditions: Esophageal Cancer

Summary: the purpose of this study is to determine whether combination of molecular and biomarkers with functional imaging can predict pathologic response and clinical outcomes in squamous esophageal cancer patients who undergo trimodality therapy which includes neoadjuvant chemoradiotherapy and surgery

the recommended care for the management of locally advanced esophageal cancers is neoadjuvant chemoradiotherapy (ncrt) followed by esophagectomy based on the nccn guideline. the rate of pathologic complete response (pcr) after ncrt was around 25-30%, reflecting potential cure of unresectable esophageal cancer receiving crt. since esophagectomy might have substantial morbidity and mortality rate, establishing the model for predicting ncrt response and survival will guide neoadjuvant treatment decisions and personalized treatment. thus surgery might be spared in some patients with complete responses after ncrt, and surgery could be selectively reserved for those with only partial or no response to crt. however, reported models yield unsatisfactory results due to small sample size and low accuracy, and most cases were adenocarcinoma and few models were used to predict survival. this study will prospectively collect the tissue and blood samples of locally advanced esophageal cancer patients, detect crt resistance biomarkers, assess the suv value and texture parameters of 18f-fdg pet-ct as well as adc values dwi-mri. the investigators will use advanced statistical tools to establish the model and further validate the model in another group of patients.the investigators will also establish a model for survival prediction. this model might possibly guide the personalized treatment for esophageal squamous cell carcinoma patients in china.

Eligibility criteria:
inclusion criteria: 1. patient must have histologic documentation of squamous carcinoma of the esophagus at xijing hospital. 2. newly diagnosed patients with localized carcinoma of the esophagus who have undergone standard testing and been evaluated by the multidisciplinary team at xijing hospital and are considered appropriate candidates for and are willing to undergo chemoradiotherapy followed by surgery at xijing hospital. 3. patient must have undergone a baseline esophageal-gastroduodenoscopy (egd) with biopsy and endoscopic ultrasonography at xijing, with tissue available for biomarker analysis. 4. patient must be willing to undergo this research and must provide written informed consent. exclusion criteria: 1. patient is unable or unwilling to comply with the requirements of the protocol. 2. history of prior malignancy within the past 3 years. 3. patients with second primary tumors. 4. patients who received endoscopical therapy or induction chemotherapy prior to chemoradiation therapy are excluded. 5. patient is not a candidate for chemoradiation followed by surgery.

Keywords: esophageal cancer prediction biomarker mri-dwi pet-ct
micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with knee osteoarthritis

Conditions: Symptomatic Knee Osteoarthritis

Summary: the study aims to evaluate the effects of a single intra-articular injection of micro-fragmented adipose tissue obtained with the lipogems® system in patients affected by knee chondropathy. end-points were determined by evaluating the patients in terms of improvement in symptoms, functional recovery and radiographic appearance compared to baseline.

background: the social impact of degenerative diseases is steadily increasing, because of the continued rise in the mean age of the active population. articular cartilage lesions are generally associated with disability and symptoms such as joint pain and reduced function, and remain a challenge for the orthopaedic surgeon. several non-invasive solution have been proposed, but the results achieved to date are far from being completely satisfactory. recently, new therapeutic approaches, such as the use of mesenchymal stem cells, have been developed. among the many sources, the adipose tissue is nowadays considered one of the smartest, due to its abundance and easy access. the aim of this retrospective study is to explore whether patients affected by symptomatic knee osteoarthritis treated with micro-fragmented adipose tissue associated with a chondral shaving procedure experience an improvement in symptoms and function. methods: thirty-eight consecutive patients affected by symptomatic knee osteoarthritis were treated in 2015 with an arthroscopic procedure associated with an injection of autologous and micro-fragmented adipose tissue. micro-fragmented adipose tissue was obtained using a minimal manipulation technique in a closed system. clinical outcomes were determined at 1, 3, 6, and 12 months follow-up using knee injury and osteoarthritis outcome score questionnaire and direct physical examination. safety of the procedure, recording type and incidence of any adverse event, was also assessed.

Eligibility criteria:
inclusion criteria: * knee chondropathy grade \> ii (icrs classification), * constant pain and failure of conservative treatments (physiokinesitherapy, corticosteroids, ha and/or prp) for at least 12 months. exclusion criteria: * immune-mediated (non-infectious) synovitis * oa kellgren-lawrence grade \>3 * axial defects \>10° * metabolic disorders * bmi \> 40

Keywords: knee chondropathy, osteoarthritis, micro-fragmented fat.
the effect of soft orthoses on balance and gait performance in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: most of the available studies that are relevant to motor rehabilitation for children with dyskinetic type of cerebral palsy are few and are comprised of small numbers of children. further researches are necessary to explore new conservative therapeutic protocols and techniques that should contribute to control disorganized movement, handle postural asymmetry, maintain postural stability, and improve gait performance. therefore, the objective of this study was to examine the effectiveness of soft orthosis and strapping system on balance, and gait performance in children with dyskinetic cerebral palsy.

dyskinetic type of cerebral palsy typically results from extrapyramidal and basal ganglia damage. the most common dyskinetic movement disorders are choreoathetosis and dystonia. their clinical features include fluctuation of muscle tone, involuntary and in-coordinated movement, and posture instability. these features have significant negative impacts on the children's quality of life and performance of daily activities. management strategy for children with dyskinesia requires both medical and rehabilitative treatment. most of the available studies that are relevant to their motor rehabilitation are few and comprised of small numbers of children. the therapeutic modalities currently used for their rehabilitation require more evidence to certain their efficacy. moreover, further researches are necessary to explore new conservative therapeutic protocols and techniques that should correct postural instability and improve the poor mobility of these children the objective of this study was to examine the effectiveness of an orthotic undergarment which is (theratog orthosis), and its strapping system on balance and gait performance in children with dyskinetic cerebral palsy.

Eligibility criteria:
inclusion criteria: * children of a confirmed diagnosis of dyskinetic cerebral palsy of choreoathetosis type were selected to participate in this study. * children (of both sexes) were between 12 and 16 years old were included . * their height and weight were more than 100 cm and 20 kg respectively to be eligible for the evaluation process on the biodex stability system. * children were able to comprehend and follow orders. * their gross motor development levels, as measured by gross motor function classification system, were between levels i and ii. * throughout the study period, participating children were not subjected to any other physical therapy programs except the assigned treatment protocol. exclusion criteria: * children were excluded from this study if they had inflexible spinal deformities interfering with spinal and limbs functional mobility. * children were also excluded if their skin were sensitive or inflamed to any materials used. * children who had seizures, perceptual disorders, visual problems, and auditory deficits did not participate as well.

Keywords: balance gait strapping orthoses
study to analyze the effects of ebi osteogen™ on the surgical reconstruction of tibia non-unions

Conditions: Tibia Fracture Non Union Bone

Summary: the purpose of this clinical outcomes collection study is to analyze the effect of the ebi osteogen™ direct current stimulator upon surgical reconstruction of tibia nonunion (no visible progressive signs of healing) fracture in a prospective database.

this clinical outcomes collection study is to analyze the effect of the ebi osteogen™ direct current stimulator upon surgical reconstruction of tibia nonunion (no visible progressive signs of healing) fracture in a prospective database.

Eligibility criteria:
inclusion criteria: 1. diagnosis of a tibia nonunion. 2. male or female between ages of 18 and 75 years old, inclusive exclusion criteria: 1. subject has open wounds or underlying osteomyelitis. 2. subject has associated multiple traumas, and/or fractures that are not anatomically reduced or lose reduction at later time points. 3. if female, subject is pregnant, plans on becoming pregnant during the duration of this clinical outcomes collection study or lactating. 4. subject has an implanted unipolar pacemaker. 5. subject has active cancer. 6. subject has severe peripheral vascular disease (abi \<0.4)
the turkish feeding/swallowing impact survey

Conditions: Deglutition Disorder; Dysphagia; Outcome Assessment; Quality of Life

Summary: the purpose of this study is to test the reliability and validity of the turkish feeding/swallowing impact survey among caregivers of pediatric patients with swallowing disorders.

the purpose of this study is to test the reliability and validity of the turkish feeding/swallowing impact survey among caregivers of pediatric patients with swallowing disorders.the internal consistency, test-retest reliability, and criterion validity of t-eat-10 will be investigated. the internal consistency will be assessed using cronbach's alpha. intraclass correlation coefficient (icc) value with 95 % confidence intervals will be calculated for test-retest reliability. the criterion validity of the scale will be determined by assessing the correlation between the turkish feeding/swallowing impact survey and karaduman chewing performance scale, tongue thrust rating scale, pediatric version of the eating assessment tool. the validity will also be determined by completion of the turkish feeding/swallowing impact survey before and after swallowing rehabilitation of pediatric patients.

Eligibility criteria:
inclusion criteria: * having a child with swallowing disorders aged between 6 months-18 years exclusion criteria: * having a child without swallowing disorders * having a child with swallowing disorders aged below 6 months
increasing hpv immunization rates: the rural adolescent vaccine enterprise

Conditions: Human Papilloma Virus

Summary: the goal of this study is to engage rural primary care clinics and community organizations to test interventions designed to increase hpv vaccinations in both male and female patients aged 9-26 years.

the overarching goal of this study is to engage rural primary care clinics and community organizations to test interventions designed to increase hpv vaccinations in both male and female patients aged 9-26 years. using a step-wedge randomized controlled trial, we will design and test the effectiveness of multi-component primary care practice-based interventions on the completion of the hpv vaccine series and will explore implementation timing in high and low functioning practices to determine how specific characteristics affect the delivery of the full series. additionally, we will design and test the impact of a community organization-based intervention intended to educate the public about hpv and cancer risk and risk reduction via vaccination.

Eligibility criteria:
inclusion criteria: * oregon family medicine and pediatric clinics located in rural communities that see adequate numbers of patients in the age range we are studying (age 11-17 years). exclusion criteria: * we will not include neonates, decisionally impaired adults, and prisoners in this study.

Keywords: immunization
a prospective study to monitor liver diseases dynamically by ultrasound viscoelasticity

Conditions: Cirrhosis; Liver Diseases

Summary: the accuracy of ultrasound elastography for assessing liver fibrosis by measuring liver stiffness (elastic modulus) is better than traditional method. elastography has certain advantage such as non-invasive, simple, real-time and it has been recommended by clinical guidelines. however, some chanllenging scientific problems showed up with further research and clinical practice. firstly, present elastography machines can only calculate liver stiffness from shear wave speed or elastic modulus but ignore other physical characteristics such as tissue viscosity. so far, present technique simply assume liver as an idealized model with isotropic elasticity to assess liver fibrosis while liver is actually anisotropic and viscoelastic. what's more, theoretically, there are not only different solid state structures such as cell organization and vessel but also flowing liquid such as blood and bile. thus, ignoring viscosity and evaluating elasticity only is unreasonable. in the other hand, a number of confounding factors have been found to influence liver stiffness measurement by elastography. different pathological chang of liver including inflammation, necrosis, cholestasis and inhomogeneity among the individuals such as obesity, ascites, et,al. will decrease the accuracy of liver stiffness measurement and liver fibrosis staging by elastography. in fact, liver fibrosis is a dynamic process. liver fibrosis is a reaction of compensation and repair for inflammation and necrosis as well as a contributing factor for liver damage. this dynamic process constitutes the common characteristic of chronic liver disease and result in the complicated biological mechanical characteristics of liver. in consequence, how to measure liver viscosity and elasticity respectively, and to evaluate liver fibrosis stage and inflammation degree accurately during the complicated and dynamic pathological process is the key scientific problem demanding solution, which is also the urgent requirement of related fundamental research and clinical practice. therefore, this project plan to apply logiq e viscoelastography machine as research tool, rat liver fibrosis model and rat liver failure model as research object to investigate the correlation between liver viscoelastography measurement and liver fibrosis stage and inflammation degree. the investigators also aim to assess the feasibility of using ulstrasound viscoelastography to evaluate liver fibrosis stage and inflammation degree dynamically.


Eligibility criteria:
inclusion criteria: * agree to have liver biopsy in later therapy * agree to participate in our study exclusion criteria: * hepatic malignant mass lesion * after liver transplantation * pregnant patients * liver biopsy specimens do not meet the requirements: speciments length \<15mm, or numbers of the portal ducts \<6.
study of azd5863 in adult participants with advanced or metastatic solid tumors

Conditions: Gastric Cancer; Gastro-esophageal Junction Cancer; Pancreatic Ductal Adenocarcinoma; Esophageal Adenocarcinoma

Summary: this research is designed to determine if experimental treatment with azd5863, a t cell-engaging bispecific antibody that targets claudin 18.2 (cldn18.2) and cd3, is safe, tolerable and has anti-cancer activity in patients with advanced solid tumors.

this is a first-time in human, modular phase i/ii, open-label multicentre study of azd5863 monotherapy administered intravenously (module 1), or azd5863 monotherapy administered subcutaneously (module 2) in patients with advanced or metastatic solid tumors. each module contains dose-escalation (part a) and dose-expansion (part b).

Eligibility criteria:
key inclusion criteria: * age ≥ 18 at the time of signing the informed consent * histologically confirmed diagnosis of adenocarcinoma of the stomach, gastro-esophageal junction, esophagus, or pancreas * must have at least one measurable lesion according to response evaluation criteria in solid tumors (recist) v1.1 * must show positive cldn18.2 expression in tumor cells as determined by central immunohistochemistry (ihc) * eastern cooperative oncology group performance status (ecog ps): 0-1 at screening * predicted life expectancy of ≥ 12 weeks * adequate organ and bone marrow function measured within 28 days prior to first dose as defined by the protocol * contraceptive use by men or women should be consistent with local regulations, as defined by the protocol * must have received at least one prior line of systemic therapy in the advanced/metastatic setting key exclusion criteria: * unresolved toxicity from prior anticancer therapy of common terminology criteria for adverse events (ctcae) grade ≥ 2 except for those defined by the protocol * participant experienced unacceptable cytokine release syndrome (crs) or immune effector cell associated neurotoxicity (icans) following prior t cell engagers (tce) or chimeric antigen receptor t (car-t) cell therapy * previous history of hemophagocytic lymphohistiocytosis (hlh) / macrophage activation syndrome (mas) * active or prior documented autoimmune or inflammatory disorders within 3 years of start of treatment * central nervous system (cns) metastases or cns pathology, as defined by the protocol, within 3 months prior to consent * infectious disease including active human immunodeficiency virus (hiv), active hepatitis b/c, uncontrolled infection with ebv, uncontrolled active systemic fungal, bacterial or other infection * cardiac conditions as defined by the protocol * history of thromboembolic event within the past 3 months prior to the scheduled first dose of study intervention * participant requires chronic immunosuppressive therapy * participants on anticoagulation therapy

Keywords: cldn18.2 / claudin 18.2 cd3 t cell-engaging bi-specific antibody gastric cancer gastro-esophageal junction cancer pancreatic ductal adenocarcinoma solid tumors azd5863
using combination of synthetic bone substitutes during extractions

Conditions: Periodontitis; Dental Caries; Alveolar Bone Losses

Summary: the study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate mixed with phosphate.

using the combination of these two bone substitute is taken in order to diminish the alveolar ridge alternations after tooth extraction. the investigator will measure the horizontal and vertical changes (primary outcome) and the adverse effects (secondary outcome)in 4 months period

Eligibility criteria:
inclusion criteria: 1. patients over age 18. 2. patients who require extraction of teeth for periodontal or other dental reasons (up one tooth in each quarter when there are existing adjacent teeth). exclusion criteria: 1. inability to pass informed consent procedure 2. pregnant women 3. breastfeeding women 4. patient taking medications that affect bone metabolism such as bisphosphonates 5. extractions sites contaminated 6. smoking over 10 cigarettes a day 7. patients with removable prostheses
quetiapine treatment for post-traumatic stress disorder (ptsd)

Conditions: PTSD

Summary: the purpose of the study is to determine if quetiapine is effective in the treatment of ptsd.

objective: to assess the impact of quetiapine on core ptsd symptoms and associated psychiatric comorbidity including depressive and positive and negative psychotic symptoms. research design: 12-week, double-blind, placebo-controlled, randomized, fixed-flexible dose trial of quetiapine monotherapy. intervention: eligible patients will be randomized to receive quetiapine starting at 25 mg daily or matching placebo. dose adjustments (to a minimum of 50 mg or a maximum of 800 mg), will be made at the investigator's discretion and according to patient's clinical response.

Eligibility criteria:
inclusion criteria: * male or female patients 18 years of age or older of any ethnic background meeting diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) criteria for ptsd. * score of at least 50 on the caps-sx at baseline. * competent to give informed consent. * if female, patient should be using a medically approved contraceptive, or not otherwise be of childbearing potential. * patients who have not taken medications or herbal remedies for a psychiatric indication within one week prior to the randomized phase. * other medications, if any, must have been kept stable for at least one month prior to randomization. exclusion criteria: * history of sensitivity to quetiapine * use of antipsychotics, antidepressants, or benzodiazepines (except for short-term use during study as specified in concomitant medications section) within one week prior to randomization and throughout the study period. * medical conditions that may prevent safe administration of quetiapine including clinically significant hepatic, cardiac, or pulmonary disease. * medical disorders that may cause or exacerbate anxiety symptoms. * alcohol or drug abuse or dependence within one month of study entry as defined by dsm-iv criteria. * schizophrenia, schizoaffective disorder, or bipolar disorder. * suicidal or homicidal ideation or other clinically significant dangerousness * currently seeking compensation or increase in compensation for the effects of the trauma. * initiation or change in psychotherapy within 3 months of randomization.

Keywords: ptsd posttraumatic stress disorder treatment quetiapine
effectiveness of sarpe with 3 and 2-segment technique: a randomized clinical trial

Conditions: Maxillary Hypoplasia

Summary: a few studies state that 3-segment sarpe has the following advantages: a) higher level of expansion symmetry; b) higher level of stability of the expansion achieved; and c) faster bone healing. the investigators hypothesize that 2-segment sarpe is as effective as 3-segment sarpe concerning treatment and/or quality of life in daily practice.

32 healthy, literate adult patients (male and female) with 7-millimeter transverse maxilla deficiency bilaterally distributed will participate in this study. the participants will be assigned randomizable in equal number to undergo either 3-segment or 2-segment sarpe. individuals that a) have undergone maxilla surgery previously; b) have craniofacial anomaly;and c) have dental crowding will not be enrolled. all participants will be assessed before and after surgery for sensitivity to pressure and temperature in the innervated structures linked to the maxilla, as well as for quality of life using ohip-49 and b-oqlq assessment tools. the expansion of maxilla will be assessed by superimposing tomographic images before and after surgery.

Eligibility criteria:
inclusion criteria: * being healthy and literate * having 7-millimeter transverse maxilla deficiency bilaterally distributed. exclusion criteria: * having undergone maxilla surgery previously * having craniofacial anomaly * having excessive dental crowding.

Keywords: maxillary expansion orthognathic surgery symmetry palatal expansion technique maxilla abnormality