Kornimate/medical-research-clean huggingface dataset:
personality-targeted interventions for adolescent alcohol misuse

Conditions: Alcohol Abuse; Drug Abuse; Depression; Panic Disorder; Conduct Disorder

Summary: personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (conrod et al., 2000) and adolescent drinkers (conrod et al, in press). as these interventions target personality traits linked to risk for addictive and non-addictive mental disorders, the aim of this study is to examine the extent to which this approach can prevent and/or reduce alcohol and drug misuse as well as have an impact on the onset or severity of emotional and behavioural problems in young people.

personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (conrod et al., 2000) and adolescent drinkers (conrod et al, in press). as these interventions target personality traits linked to risk for addictive and non-addictive psychopathology, the aim of this study is to examine the extent to which this approach is effective in preventing and/or reduce alcohol and drug misuse and concurrent psychiatric symptoms in young people. method: 875 participants aged 13-16 years will be screened for personality risk in school-wide self-report assessments. participants will be randomly assigned to a personality matched cognitive-behavioural intervention or a no-intervention control. the personality matched interventions will target four personality risk factors: negative thinking (nt), anxiety sensitivity (as), impulsivity (imp) and sensation seeking (ss). outcome evaluation will occur 6, 12, 18 and 24 months post intervention. primary outcomes will be time to onset and severity of alcohol and illicit substance use and misuse. secondary outcome variables will include depressive symptoms, panic attack rates, reckless and antisocial behaviour. secondary analyses involving genetic, cognitive and coping skills measures will examine moderators of treatment effects. hypotheses: it is expected that personality-targeted interventions will have personality-specific effects on aspects of addictive and non-addictive psychopathology to which each personality risk group is most susceptible.

Eligibility criteria:
inclusion criteria: * secondary school student * scoring one standard deviation above the school mean on one of 4 personality dimensions. * able to provide consent from parent/guardian for participation in the study exclusion criteria: * none

Keywords: prevention addiction personality adolescents binge drinking alcohol abuse comorbidity depression anxiety antisocial behaviour
prognostic significance of the baroreflex sensitivity changes after acute ischemic stroke

Conditions: Cerebrovascular Accident; Baroreflexes; Autonomic Nervous System Diseases

Summary: after acute stroke, baroreflex sensitivity (brs) is impaired. this impaired acute stage brs has been reported to be predictive of worsen outcome years after stroke in general. however, it is not very clear if the impaired acute stroke brs would actually persist months after the acute stage. it is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke. the trial is to investigate the longitudinal time course of brs after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in brs with the functional outcome parameters using nihss and mrs scores throughout this period.


Eligibility criteria:
inclusion criteria: * baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke * 50-80 years old * must have either brain ct or brain mri done exclusion criteria: * nihss score \> 10 * patient could not cooperate * unstable vital sign * atrial fibrillation * transient ischemic attack patient * diabetic patient * impaired renal function (cr \> 2.26 mg/dl) * unstable angina, acute myocardiac infarction, cardiomyopathy patients * patient who has known autonomic dysfunction

Keywords: ischemic stroke baroreflex sensitivity prognosis cardiovascular autonomic regulation
a phase 3 study of pembrolizumab + epacadostat or placebo in subjects with unresectable or metastatic melanoma (keynote-252 / echo-301)

Conditions: Melanoma

Summary: the purpose of the study is to assess the efficacy, safety, and tolerability when combining pembrolizumab with epacadostat or placebo in participants with unresectable or metastatic melanoma


Eligibility criteria:
inclusion criteria: * have histologically or cytologically confirmed melanoma * have unresectable stage iii or stage iv melanoma, as per ajcc staging system not amenable to local therapy * a minimum of 1 measurable lesion by ct or mri * provide a baseline tumor biopsy * eastern cooperative oncology group (ecog) performance status of 0 to 1 exclusion criteria: * has received prior systemic treatment for unresectable or metastatic melanoma (except braf directed therapy) * has received prior therapy with an anti-pd-1, anti-pd-l1, anti-pd-l2, anti-cd137, or ido1 inhibitor or any other antibody or drug specifically targeting checkpoint pathways other than anti-ctla-4 which is permitted in the adjuvant setting * has received prior adjuvant therapy, monoclonal antibody or an investigational agent or device within 4 weeks or 5 half-lives (whichever is longer) * has an active infection requiring systemic therapy * has known history of human immunodeficiency virus (hiv) (hiv 1/2 antibodies) * has known history of or is positive for hepatitis b or hepatitis c * is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study treatment

Keywords: melanoma metastatic melanoma
prediction model of vitamin d deficiency

Conditions: Critical Illness

Summary: many studies have pointed out that patients with vitamin d deficiency have a longer stay in the intensive care unit and a poor prognosis. previous multi- center prospective observational study in taiwan reveals that the prevalence of vitamin d deficiency in critically ill patients in northern taiwan is 59%, and the prevalence of severe vitamin d deficiency is 18%. several prediction models of vitamin d deficiency had been built for the general population but not patients admitted in intensive care units. this multi-center retrospective study aims to develop and validate a score-based prediction model for severe vitamin d deficiency in critically ill patients. investigators will review the data of previous multicenter, prospective, observational study. for temporal validation, the data will be divided into a derivation cohort (first 80% of the data set based on chronology) and a validation cohort (the remaining data set). the development and validation of the models will be carried out following the recommendations established in the transparency reporting of a multivariable prediction model for individual prognosis or diagnosis (tripod) initiative.


Eligibility criteria:
inclusion criteria: * patients admitted to intensive care units exclusion criteria: * aged \< 20 years * admitted to intensive care unit longer than 28 days * body max index \< 18 kg/m2 * receive vitamin d supplement \> 3000 iu/day * previously admitted to intensive care unit within 3 months * have parathyroid disease, rickets, or severe liver cirrhosis \[child c\]

Keywords: critical care vitamin d
epidural stimulation in chronic spinal cord injury patients

Conditions: Spinal Cord Injuries

Summary: investigators propose to demonstrate that epidural stimulation (es) can be used to recover significant levels of autonomic control of cardiovascular, urinary and sexual function as well as the ability to voluntarily control leg movements below the injury level. this intervention would provide an immediate therapeutic alternative to individuals who now have no recourse for treatment. in addition investigators suggest to prove on functional magnetic resonance imaging if there are some significant changes before and after the stimulation.


Eligibility criteria:
inclusion criteria: * non-progressive sci with complete motor paralysis below t1; american spinal injury association impairment scale (ais) a or b * 18 - 60 years of age; * longer than 2 years post injury; * stable medical condition * unable to voluntarily move all single joints of the legs; * spinal cort lesion between c7 and th10 exclusion criteria: * ventilator dependent; * painful musculoskeletal dysfunction, unhealed fracture, contracture, or pressure sore that might interfere with training; * clinically significant depression or ongoing drug abuse; * cardiovascular, respiratory, bladder, or renal disease unrelated to sci; * severe anemia (hgb\<8 g/dl) or hypovolemia; and hiv or aids related illness.

Keywords: spinal cord injury spinal cord stimulation volitional movement functional magnetic resonance imaging autonomic nervous system
brief mood enhancement intervention

Conditions: Stress, Psychological; Burnout, Professional

Summary: the purpose of the current study is to test the efficacy of two brief, behavioral interventions intended to improve burnout among doctoral-level graduate students (n = 102). specifically, individuals will be randomly assigned to one of three intervention conditions: 1) reward: a brief intervention to help participants increase engagement in healthy and rewarding values-driven behaviors, 2) approach: a brief intervention to help participants identify and decrease emotion-driven avoidance of important goals, or 3) control: a control condition that involves monitoring only. multilevel modeling will be used to assess changes in burnout, mood, and stress, following the interventions, controlling for participants' individual baseline levels of these variables.


Eligibility criteria:
inclusion criteria: * currently enrolled in any in-person (not online) ph.d. program in the state of north carolina * demonstrating above average levels of burnout * has regular access to the internet * has a social security number * is able to read and understand english exclusion criteria: * current mania or psychosis * current suicidal ideation * are currently in psychotherapy, have been in psychotherapy in the past 8 weeks, or are planning to start psychotherapy during the course of the 10-day study * have had any changes in psychiatric medications in the past 8 weeks, are not taking medications as prescribed or are planning to change medications during the course of the 10-day study * are currently taking benzodiazepines pro re nata (prn) * are under 18 years old

Keywords: graduate student burnout stress mood
ckd cachexia and gut microbiome

Conditions: Chronic Kidney Diseases; Cachexia

Summary: cachexia is common in patients with chronic kidney disease (ckd) and is associated with increased morbidity and mortality. cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main contributing factors. in this context, the role of the gut microbiome in ckd cachexia and the potential benefit of increasing the dialysis dose have been poorly explored. here the investigators propose to study the links between cachexia and the gut microbiome, in association with inflammation and uremic toxins, in dialysis. the specific objectives are the followings: 1. set up a prospective cohort of deeply characterized kidney failure patients treated with hemodialysis (in-center, self-care dialysis in a satellite unit and at home) and peritoneal dialysis, including evaluation of cachexia, body composition, collection of feces and blood to characterize the gut microbiota, measure serum levels of uremic toxins and inflammatory markers, with a longitudinal follow-up. 2. to compare cachectic versus non-cachectic dialysis patients in terms of gut microbiota, inflammatory markers, level of uremic toxins, muscle transcriptome, dialysis dose and modality. in a subgroup analysis, the investigators plan to compare the different techniques of dialysis (in-center vs home-hemodialysis vs peritoneal dialysis).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of kidney failure (stage v) * maintenance dialysis for at least 3 months * understanding of the trial procedures and ability to adhere to the trial protocol exclusion criteria: * severe nonadherence to the dialysis procedure * life expectancy below 1 year * chronic inflammatory disease of the digestive tract (crohn's disease, ulcerative colitis) * bariatric surgery * active cancer * pregnancy * antibiotics consumption in the month preceding the inclusion * gastro-intestinal surgery, colonoscopy, or probiotics consumption in the 3 months preceding the inclusion * drugs influencing body composition initiated ≤ 1 month : systemic corticosteroids, anabolic drugs as insulin or testosterone, post-menopausal hormone therapy, injectable contraceptives. * known endocrinological disorders potentially leading to hypo- or hypermetabolism, untreated or treated for ≤ 1 month : disorders of thyroid gland, adrenal glands... * patients under weight loss drugs : glp1 agonists, orlistat

Keywords: cachexia protein energy wasting microbiota chronic kidney disease dialysis
healthcare-associated infections in severe covid-19 during 2020

Conditions: Respiration, Artificial; COVID-19; Health Care Associated Infection

Summary: in patients who develop ards due to sars-cov-2 (cards), a longer duration of invasive mechanical ventilation (imv) and icu stay has been reported compared to ards not associated with sars-cov-2. consequently, the days of stay in icu increase identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

the rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent icus. some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to latin america. the objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed covid-19 diagnosis and negative covid-19 admitted to the intensive care unit of the anchorena san martín clinic, san martín, buenos aires.

Eligibility criteria:
inclusion criteria: * all patients older than 18 years admitted to the intensive care unit of the anchorena san martín clinic who required invasive mechanical ventilation for more than 24 hours in a period between march 2020 and december 2020 were included in the analysis. exclusion criteria: * all patients who presented incomplete data in the follow-up sheets were excluded.
adenovirus initiative study in epidemiology in italy

Conditions: Viral Conjunctivitis

Summary: the objectives of this study is to assess the characteristics and frequency of adenovirus conjunctivitis in a population of male and female patients from one year of age who present signs and symptoms of acute conjunctivitis.

epidemiological, prospective, open, multicentric trial in patients suffering from acute conjunctivitis who will undergo a rapid diagnostic test for adenoviral conjunctivitis at the time of their visit to the ophthalmologist office, at the emergency room or during hospitalization. this epidemiological study will include approximately 500 patients in italy. the planned duration of the study is one year from the first patient visit to the last patient visit.

Eligibility criteria:
inclusion criteria: * male or female patients of at least one year of age presenting acute (for less than 7 days) conjunctivitis signs and symptoms. * patient or / and legal representative (if patient below 18 years of age) must be able to provide oral consent for the collection and treatment of the questionnaire data. * no history of hypersensitivity to corn starch, talcum powder or dacron (sampling fleece components). exclusion criteria: * current use or having received (within the last 7 days) local antiviral therapies such as povidone iodine or ganciclovir, or topical steroids or immunomodulators such as cyclosporine which may interfere with the test result. * previous enrolment in the present study. * any direct involvement with the study conduct at site or any family link with study site staff.

Keywords: adenoviral conjunctivitis diagnosed with adenoplus™ test
effects of muscle energy technique in knee osteoarthritis patients

Conditions: Knee Osteoarthritis

Summary: to determine the effectiveness of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee osteoarthritis patients regarding pain, range of motion, functional disability and quality of life.

mesenchymal stem cells (mscs) replacement is a regenerative therapeutic procedures for the early treatment of cartilaginous defects in knee osteoarthritis. mscs may improve symptoms and function in osteoarthritic joints but also decrease inflammation and induce cartilage healing by differentiating into chondrocytes, osteoblasts and indicating appropriate extracellular matrix proteins (i.e. collagen i and ii) through the secretion of cytokines, chemokines, and growth factors from mscs.

Eligibility criteria:
inclusion criteria: * both male and female * age \> 40 years * knee osteoarthritis patients undergone mesenchymal stem cell transplantation. exclusion criteria: * history of recent or past septic arthritis * patients with neurological deficit * uncontrolled diabetes * malignancy * vascular insufficiency

Keywords: mesenchymal stem cells (mscs), muscle energy technique (met), rehabilitation protocol
disulfiram in treating patients with glioblastoma multiforme after radiation therapy with temozolomide

Conditions: Glioblastoma

Summary: this clinical trial studies disulfiram in treating patients with glioblastoma multiforme (gbm) who have completed radiation therapy with temozolomide. disulfiram may block some of the enzymes needed for tumor cell growth and improve clinical outcome in gbm patients.


Eligibility criteria:
inclusion criteria: * diagnosis of histologically confirmed gbm (who grade iv). * at least 18 years of age. * ecog performance status of at least 2. * has received or is in the process of completing a course of definitive radiotherapy of at least 45 gy with concurrent temozolomide (patient may be registered before completing radiotherapy as long as it is anticipated that s/he will complete at least 45 gy). * eligible for and planning to receive maintenance temozolomide after completion of definitive radiotherapy plus temozolomide. * willing to remain abstinent from consuming alcohol while on disulfiram. * meets the following laboratory criteria: * absolute neutrophil count ≥ 1,500/mcl * platelets ≥ 100,000/mcl * hemoglobin \> 9.0 g/dl (transfusion and/or esa allowed) * total bilirubin ≤ 2x institutional upper limit of normal (uln) * ast and alt \< 3 x uln * calculated creatinine clearance must be \> 60 ml/min (by cockcroft-gault) * females of childbearing potential (defined as a female who is non-menopausal or surgically sterilized) must be willing to use an acceptable method of birth control (i.e., hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study. should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately. * able to take oral medication. * able to understand and willing to sign an irb-approved written informed consent document (legally authorized representative permitted). exclusion criteria: * receipt of any other investigational agents within 14 days prior to study enrollment. * enrolled on another clinical trial testing a novel therapy or drug. * history of allergic reaction to disulfiram. * treatment with clinically significant cytochromes p450 enzyme inducers, such as phenytoin, phenobarbital, chlordiazepoxide, diazepam, isoniazid, metronidazole, warfarin, amitriptyline within 14 days prior to the first dose of disulfiram. of note, lorazepam and oxazepam are not affected by the p450 system and are not contraindicated with disulfiram. * active or severe hepatic, cardiovascular, or cerebrovascular disease, including myocardial infarction within 6 months prior to enrollment, have new york heart association (nyha) class iii or iv heart failure (appendix b), uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. * history of idiopathic seizure disorder, psychosis or schizophrenia. * pregnant and/or breastfeeding. women of childbearing potential must have a negative pregnancy test within 14 days of initiation of treatment.
does nerve block + oral dexamethasone reduce recurrence of headache within 72 hrs?

Conditions: Migraine

Summary: for some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (phnb) have proven to be an efficient and effective treatment for headache relief. previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.

previous studies have provided evidence that administering steroids in addition to standard migraine headache treatment in the emergency department may reduce the recurrence of the headache within 24-72 hours. the standard migraine treatments in previous studies have been varied and include 5-ht receptor agonists, dopamine antagonists, dihydroergotamine, nsaids, and opioid analgesics. the steroids added to the standard treatment have been prednisone and dexamethasone (both iv and oral). this is the first study to examine the combination of peripheral nerve block as the primary treatment of migraine followed by oral dexamethasone to prevent recurrence.

Eligibility criteria:
inclusion criteria: * meet ichd-3 migraine headache criteria * had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2 * nerve block performed with bupivacaine 0.5% exclusion criteria: * head trauma * suspicion of secondary headache (i.e. stroke, known tumor, glaucoma) * headache in the setting of viral syndrome * chronically on steroids * known allergy to dexamethasone * unable to reach the patient by phone or text for follow-up * gestational diabetes or other uncontrolled diabetes * known to be immunocompromised

Keywords: migraine headache peripheral nerve block dexamethasone steroid treatment
efficacy and safety of sericin and chitosan cream for preventing and limiting the progressive of pressure sore

Conditions: Pressure Ulcer

Summary: to evaluate efficacy and safety of sericin and chitosan cream for preventing and limiting the progressive of pressure sore in 20 patients


Eligibility criteria:
inclusion criteria: * age more than 18 years old * 2-digit stirling pressure sore severity scale less than or equal to 2.4 * no chitosan, sericin, and dimethicone allergy * without skin diseases * without autoimmune diseases * willingness to participate exclusion criteria: * have uncontrolled diseases * have complication or adverse effects during the time of participation * cannot follow protocol * pregnancy or lactation * participate in other study