Kornimate/medical-research-clean huggingface dataset:
inferior submucosal turbinectomy versus blunt turbinectomy for inferior turbinate hypertrophy

Conditions: Bilateral Inferior Turbinates Hypertrophy

Summary: the aim of the study is to compare endoscopic submucosal inferior turbinectomy to blunt turbinectomy in terms of subjective and objective parameters.

the two methods of nasal inferior turbinectomy are well popularized and in use for long periods of time. endoscopic submucosal inferior turbinectomy is performed in our hospital and blunt turbinectomy is performed usually in privat clinics outside the hospital where there is no endoscopic equipment. we will examine both subjective (qol questionaire) and objective parameters(rhinomanometry- a non invasive method to evaluate nasal airflow, saccharine test, nasal endoscopy) in our comparison of the outcome of these two methods.

Eligibility criteria:
inclusion criteria: * all patients above 18 years exclusion criteria: * can not answer a written questionaire

Keywords: turbinectomy
goal-directed mobilization of medical inpatients

Conditions: Immobility Syndrome; Fall; Delirium; Sarcopenia; Mobility Limitation; Hospital Acquired Condition

Summary: immobilization in general internal medicine inpatients is a major contributor to morbidity and mortality. goal-directed mobilization (gdm) may improve mobility. the aim of this study is to assess, if gdm increases physical activity (demmi score) during hospitalization and improves quality of care until 3 months after hospitalization.


Eligibility criteria:
inclusion criteria: * all consenting patients aged ≥ 18 years admitted to the department of general internal medicine, inselspital, bern university hospital, bern, switzerland, who have an indication for physiotherapy (prescription by the resident in charge or the care coordinator). * participants must be randomized at latest on the second day after hospital admission. * written informed consent. exclusion criteria: * inability to follow study procedures, i.e., due to language problems (unable to read, speak or understand german), psychological disorders, severe dementia (defined as to levels 5 - 7 in the global deterioration scale), blindness, patients unable to provide informed consent themselves * expected hospital stay for \< 5 days * medically indicated bedrest for more than 24 h, e.g. after surgery * injuries or neurologic deficits of one or both lower extremities directly impairing walking capacity (e.g. fractures, hemiplegia, previous use of a wheelchair or bedriddenness) * terminal illness * pregnancy or breast feeding * previous enrolment in this study * enrolment of the investigator, his/her family members, employees and other dependent persons
a smartphone application of "family connections" to relatives of people with borderline personality disorder.

Conditions: Relatives

Summary: the aims of our study are the following: (a) testing the effectiveness of a combined intervention: "family connections" program with a smartphone app versus the same intervention supported by a paper-based manual, (b) studying the feasibility and acceptance of both conditions and (c) evaluating the perceptions and opinions of families about both interventions.

family members of patients with borderline personality disorder (bpd) often experience high levels of suffering, anxiety, stress, burden and helplessness. the treatment program with the most empirical support is "family connections". it is one of the first programs specifically designed to help relatives of patients with bpd. the program is an adaptation of multiple strategies of dialectical behavioral therapy. the results of these studies and their subsequent replications showed an improvement in family attitudes and perceived burden. two of the technologies with very promising developments are ecological momentary assessment and ecological momentary intervention, that can act on each other. a large number of smartphone apps for people with psychological problems focus on the provision of instructions, adaptive self-help strategies, alarms, electronic diaries or emotional state ratings. the family connections app proposed in this article consists of a smartphone app built using ema and emi technologies.the aims of our study are the following: (a) testing the effectiveness of a combined intervention: "family connections" program with a smartphone app versus the same intervention supported by a paper-based manual, (b) studying the feasibility and acceptance of both conditions and (c) evaluating the perceptions and opinions of families about both interventions.

Eligibility criteria:
inclusion criteria: * having a family member diagnosed with borderline personality disorder. * being 18 years of age or older. * knowing and understanding the spanish language. * having a smartphone with internet connection. * completing the informed consent.

Keywords: borderline personality disorder family connections relatives dbt smartphone app technology
retrospective follow-up of synvisc® in active patients with knee osteoarthritis

Conditions: Osteoarthritis

Summary: retrospective collection of data, aimed at a better knowledge of the context of use of synvisc® among the patients practising a regular activity (professional/leisure), and at evaluating the different practices and their results.


Eligibility criteria:
inclusion criteria: * use of synvisc® * patients practising a regular activity (professional/leisure) exclusion criteria: * none
igg-4 levels in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: this is an observational - non interventional study. the investigators will compare igg4 levels of 80 healthy donors (from israel blood bank - mda) and 80 systemic sclerosis patients from meir medical center.

igg4 levels will be obtained from medical records of 80 ssc patients between the years 2000-2019. these will be compared to igg4 levels from sera of 80 healthy donors (from israel blood-bank - mda). correlations between igg4 levels and the following will be made: age, sex, disease type (limited or diffused ssc), disease duration, medications.

Eligibility criteria:
inclusion criteria: * ssc patients exclusion criteria: * other chronic co-morbidities

Keywords: ssc igg4
exploring the application of 3d bioprinting for personalized treatment in pancreatic ductal adenocarcinoma

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: the goal of this observational study is to test the application value of 3d bioprinting technology in personalized treatment of pancreatic cancer. the main questions it aims to answer are: * can 3d bioprinting technology be successfully applied to establish preclinical models of pancreatic cancer? * can 3d bioprinted preclinical models of pancreatic cancer be applied to personalized treatment of pancreatic cancer? participants will have tumor tissue collected to extract primary tumor cells for the establishment of in vitro preclinical models, which will be used for drug sensitivity testing.


Eligibility criteria:
inclusion criteria: * more than 18 years old * diagnosed as colorectal cancer with or without liver metastases before * pathologically proven colorectal cancer after surgery exclusion criteria: * history of other malignancies or serious medical conditions * inability to provide independent informed consent
a study of der 45-ev gel to treat rosacea

Conditions: Rosacea

Summary: to identify lowest efficacious dose of der 45 ev gel, 1% and 5% verses vehicle in patients with rosacea.


Eligibility criteria:
inclusion criteria: * males and females, 18 years of age or older * facial rosacea, with 12 or more inflammatory lesions (with no more than 2 nodules) * mild, moderate or severe (2, 3 or 4) rating of rosacea on the iga * females of child-bearing potential must have negative urine pregnancy test result at baseline and must be willing to use an effective form of contraception throughout the study exclusion criteria: * subjects who are pregnant, breast feeding, or planning a pregnancy during the study * allergy or sensitivity to ingredients in test product * any dermatological conditions of the face that may interfere with study evaluations * subjects unable to avoid or minimize exposure to factors that may exacerbate or trigger rosacea
a phase ii study to assess the efficacy and safety of sc10914 in the metastatic breast cancer patients

Conditions: Breast Cancer Metastatic; BRCA 1 Gene Mutation; BRCA 2 Gene Mutation

Summary: this open label, multi-centre phase ii study will assess the efficacy and safety of single agent sc10914 in metastatic breast cancer patients with gbrca 1/2 mutations.


Eligibility criteria:
inclusion criteria: 1. germline mutation in brca1 or brca2 2. histologically or cytologically confirmed breast cancer with evidence of metastatic disease. 3. prior therapy with an anthracycline and/or a taxane in either an adjuvant or metastatic setting 4. patients who have received platinum (cisplatin or carboplatin, either as monotherapy or in combination) for advanced breast cancer are eligible to enter the study provided platinum-free interval at least 6 months (time from last dose of platinum chemotherapy to disease progression 5. patients who have received platinum as potentially curative treatment for a prior cancer (e.g. ovarian cancer) or as adjuvant/neoadjuvant treatment for breast cancer are eligible provided at least 12 months have elapsed between the last dose of platinum-based treatment and eligible . 6. patients with estrogen and/or progesterone receptor-positive disease must have received and progressed on at least one endocrine therapy (adjuvant or metastatic), or have disease that the treating physician believes to be inappropriate for endocrine therapy . 7. at least one lesion (measurable and/or non-measurable) that can be accurately assessed at baseline by ct (mri where ct is contraindicated) and is suitable for repeated assessment as per recist 1.1. 8. ecog performance status 0-1. 9. adequate bone marrow, kidney and liver function exclusion criteria: 1. prior treatment with parp inhibitor. 2. patients with her2 positive disease 3. untreated and/or uncontrolled brain metastases 4. known hiv (human immunodeficiency virus) infection. 5. persistent toxicities (≥ctcae grade 2) caused by previous cancer therapy, excluding alopecia 6. pregnant or breast feeding women
a double-blind randomized clinical trial on the efficacy of magnetic sacral roots stimulation for the treatment of ne

Conditions: Nocturnal Enuresis

Summary: the purpose of this study is to assess the efficacy of daily sacral root magnetic stimulation for 10 sessions in patients with nocturnal enuresis.eligible patients were randomized to receive either real or sham repetitive sacral root magnetic stimulation (rsms; 15 hz with a total of 1500 pulses/session) for 10 sessions. evaluation was performed before starting treatment, immediately after the 5th and 10th treatment session, and 1 month later, using frequency of enuresis/week, visual analogue scale (vas) and quality of life. cortical excitability of upper and lower limbs were done before and after the end of sessions.

the purpose of this study is to assess the efficacy of daily sacral root magnetic stimulation for 10 sessions in patients with nocturnal enuresis. eligible patients were randomized to receive either real or sham repetitive sacral root magnetic stimulation (rsms; 15 hz with a total of 1500 pulses/session) for 10 sessions. evaluation was performed before starting treatment, immediately after the 5th and 10th treatment session, and 1 month later, using frequency of enuresis/week, visual analogue scale (vas) and quality of life. cortical excitability of upper and lower limbs were done before and after the end of sessions.

Eligibility criteria:
inclusion criteria: * all subjects diagnosed as patients with primary monosymptomatic nocturnal enuresis according to the diagnostic and statistical manual of mental disorders, 4th revised edn (dsm-iv) exclusion criteria: * we exclude any patient with pacemakers or any metallic devices * patients with evidence of urinary tract infection.
vf mapping in brugada and early repolarization syndromes

Conditions: Brugada Syndrome; Early Repolarization Syndrome

Summary: to determine the values and limitations of ecgi in guiding ablation and risk stratification in patients with brs and early repolarization.

the investigators will study symptomatic brs and ers syndrome (n=25) and asymptomatic patients (n=25) age between 16-70 years old to determine values and limitations of non-invasive mapping using electrocardiographic imaging (ecgi) in identifying vf substrates as target sites for catheter ablations in patients with brugada (brs) and early repolarization syndromes (ers) and also determine the mechanisms of vf in brs and ers syndromes.

Eligibility criteria:
inclusion criteria: patients presenting with the type1 brs ecg or er ecg signature pattern, with/without a sodium channel blocker. patients with the following one of these symptoms or arrhythmias will be considered as symptomatic patients: 1) aborted cardiac arrest cases, 2) documented vf episodes, 3) agonal respiration during sleep with difficulty to arouse, 4) syncope of unknown origin, or 5) seizure suspected of arrhythmic origin.• exclusion criteria: patients who refuse informed consent and to participate to the best ability in the study. patients who have structural heart disease or concomitant medical illness.
evaluation of lum001 in the reduction of pruritus in alagille syndrome

Conditions: Alagille Syndrome

Summary: the study is a randomized, double-blind, placebo-controlled study in children with alagille syndrome (algs). the study will investigate the effects of lum001, compared to placebo, on pruritus, serum bile acids, liver enzymes, and other biochemical markers in patients with algs.


Eligibility criteria:
inclusion criteria: 1. diagnosis of alagille syndrome 2. evidence of cholestasis 3. moderate to severe pruritus 4. ability to understand and willingness to sign informed consent/assent prior to initiation of any study procedures exclusion criteria: 1. surgical disruption of the enterohepatic circulation 2. liver transplant 3. history or presence of other concomitant liver disease 4. females who are pregnant or lactating 5. known hiv infection
fastforwardtm bunion correction system in treating hallux valgus patients

Conditions: Hallux Valgus and Bunion (Disorder)

Summary: the fastforwardtm bunion correction system has been cleared by the united states food and drug administration for sale. this study is to investigate the clinical outcome of medshape fastforwardtm bunion correction system in treating hallux valgus patients at cmuh. criteria-there will be 12 subjects with a painful bunion and hallux valgus between 20 and 65 years of age and an adequate range of movement. patients with rheumatoid arthritis, failed previous hallux valgus surgery and symptomatic and/or radiological arthritis of the mtp joint will be excluded. protocol-the pi and sc explain the detail and purpose of the project to the patient to the language to the patient is comfortable with. the explanation has to be at least 1 hour. be sure the patients understand the full detail before the surgery. computer tomography scan, gait analysis and blood biochemical analysis will be taken in 1-2 weeks after patient is enrolled in the subject. before surgery, the titration bone tether plate designed to match patent's second metatarsal contour will be manufactured using 3d printing technology. printed titanium plate and peek screws used to secure tethering suture tape in the first metatarsal will be sterilized prior implantation. the surgery time, recovery period and effectiveness after implantation will be recorded. to observing the recovery situation, patients will back to out-patient clinic at 1st, 2nd, 3rd, 4th, 6th, 12th, 24th weeks. during these period, physical examination, wound dressing, vas, x-ray scan will be arranged. the detail arrangements below: 1.1st week: physical examination, wound dressing, vas 2.2nd week: physical examination, wound dressing, vas 3.3rd week: physical examination, wound dressing, vas, x-ray scan, remove stiches 4.4th week: physical examination, vas 5.6th week: physical examination, vas, x-ray scan 6.12th week: physical examination, vas, x-ray scan 7.24th week: physical examination, vas, x-ray scan, ct scan, gait analysis


Eligibility criteria:
inclusion criteria: * patients with a painful bunion and hallux valgus between 20 and 65 years of age and an adequate range of movement exclusion criteria: * patients with rheumatoid arthritis, failed previous hallux valgus surgery and symptomatic and/or radio-logical arthritis of the mtp joint

Keywords: hallux valgus and bunion
stereotactic ablative radiotherapy for refractory ventricular tachycardia

Conditions: Refractory Ventricular Tachycardia

Summary: single arm, phase ib/2a dose escalation study with an expansion cohort to determine the maximal tolerated dose (mtd) for stereotactic ablative radiotherapy of targets in the cardiac myocardium and to make a preliminary assessment of the efficacy of the treatment. the dose escalation will be guided by time-to-event continual reassessment method (tite-crm) to ensure more patients will be spared dose limiting toxicities and more patients will be entered on the dose level that will be chosen as minimal dose of maximal effect. this design also allows for continual accrual of patients when delayed adverse events may be observed.


Eligibility criteria:
inclusion criteria: documented sustained ventricular arrhythmias refractory to or not a suitable candidate for catheter based rfa ablative therapy * documented sustained ventricular arrhythmias refractory to or not a suitable candidate for cardiac sympathetic denervation therapy * documented ventricular arrhythmias refractory to or not a suitable candidate for cardiac transplantation * documented sustained ventricular arrhythmias refractory to or not a suitable candidate for additional medical management * icd in place with documented episodes recurrent vt despite best clinical management previous refusal of icd with recurrent sustained ventricular arrhythmias * if ischemic cardiomyopathy, myocardial infarction occurred more than one month prior to enrollment * no history of prior radiotherapy to the chest * prescribed dose must be deliverable using sabr technique * age ≥ 18 years * karnofsky performance status (kps) \> 70 * if a woman is of childbearing potential, a negative serum pregnancy test must be documented. women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) for at least 4 weeks after study treatment. * ability to understand and willingness to sign a written informed consent
pilot 3d mammography reader study to assess breast cancer detection in 3d versus 2d digital mammography

Conditions: Breast Cancer

Summary: the purpose of this pilot study is to provide credible performance estimate information in order to properly plan, design, and power a larger clinical study.


Eligibility criteria:
inclusion criteria: * female subjects participating in prior fmsu protocol with known clinical status exclusion criteria: * subjects with unkown clinical status * subjects not truthed in prior fmsu study

Keywords: mammography 3d breast cancer detection
modifying young adult skin cancer risk and protective behaviors

Conditions: Melanoma and Other Malignant Neoplasms of Skin

Summary: skin cancer is the most common cancer and can be deadly, debilitating, damaging, and disfiguring, yet is highly preventable. in 2014, the us surgeon general made a call to action about the "major public health problem" of skin cancer, noting potential contributions of behavioral science and education, and a need for investments in such efforts. almost five million americans are treated for skin cancer annually, and incidence is rising. risk factors for melanoma and non-melanoma skin cancers include personal or family history of skin cancer, certain physical characteristics (e.g., fair skin, numerous moles), as well as excessive ultraviolet (uv) radiation exposure. our work shows that skin cancer risk behaviors, including sunburns, indoor tanning, and lack of protection peak at age 25. thus, young adulthood is an important window for skin cancer risk reduction interventions. however, young adults tend to be resistant to public health recommendations because, as a group, they perceive themselves as having more immediate priorities than disease prevention, that the consequences of their current health behaviors are in the distant future, and they also tend to be experimenters and risk-takers highly influenced by peers. the principal investigator developed a web-based intervention (uv4.me) that was found to significantly decrease uv exposure and increase skin protection behaviors among young adults in a randomized controlled trial of nearly 1000 participants. the objective of this project is to investigate the reach, effectiveness, implementation, maintenance, and cost of an enhanced version of that web intervention (uv4.me2) in a large national randomized controlled trial. the ultimate goal is to improve the skin cancer protection behaviors (and potentially decrease skin cancer incidence) among a national sample of young adults at moderate to high risk of developing skin cancer. primary aim 1. to enhance and determine intervention reach (i.e., enrollment, representativeness). primary aim 2. to determine the effectiveness of the enhanced intervention. secondary aim 1. to determine maintenance of the uv4.m4 and uv4.me2 interventions through evaluation at 6 and 12-month follow-up. secondary aim 2. to determine intervention implementation by young adults. secondary aim 3. to determine the costs of the uv4.me and uv4.me2 interventions.


Eligibility criteria:
inclusion criteria: * moderate to high risk for skin cancer exclusion criteria: * not able to speak english * past history of skin cancer