Kornimate/medical-research-clean huggingface dataset:
medical chart review of patients on long-term treatment with long-acting injectable risperidone

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: the purpose of the study is to evaluate the characteristics, clinical responses, and safety issues of patients receiving long-term treatment of risperidone long-acting injectable. the goal is to evaluate patient outcomes based on pre-existing risk or disease factors and past medication use.

this is an observational, retrospective study on the use of risperidone long-acting injectable. the purpose of the study is to evaluate the characteristics, clinical responses, and safety issues of patients receiving long-term treatment of risperidone. patient outcomes will be evaluated based on pre-existing risk or disease factors and past medication use. data will be collected from medical charts and other available medical records from one year prior to risperidone treatment until discontinuation of risperidone long acting injectable. the study will compare the number of days hospitalized for reasons relating to psychosis before and after treatment with risperidone long-acting injectable. information about past use of anti-psychotic medications will be collected. the occurrence and frequency of adverse events \[extra-pyramidal symptoms (eps) - the abnormal body movements sometimes associated with antipsychotic medications, body weight changes, drowsiness, sexual problems\] and the dose or change in dose of risperidone long-acting injectable will also be collected. the study will also investigate the relapse rate and the hospitalization rate before and after treatment. it is a chart review type of study. no study drug has been used in the study.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or schizoaffective disorder by dsm-iv-tr criteria * patients who used to be treated with risperidone long-acting injectable regularly for at least 3 months * patients whose medical charts or other medical records are available exclusion criteria: * none

Keywords: schizophrenia schizoaffective disorder risperidone long-acting injectable, long-term evaluation
complications related carboxyhemoglobin levels in second hand smoking pediatric tonsillectomy patients

Conditions: Secondhand Smoking

Summary: the purpose of this study was to determine whether high carboxyhemoglobin level is a risk factor for postoperative adverse events in children exposured to carbon monoxide, especially enviromental tobacco smoke.

also we want to measure bleeding volume and compare it with the carboxyhemoglobin levels.

Eligibility criteria:
inclusion criteria: -patients 1-12 years old scheduled for adenotonsillectomy; written informed consent. exclusion criteria: * active smokers, history of prematurity, bleeding disorders, hemolysis, severe pulmonary disease, home oxygen use, and inpatient hospitalisation≥24 h.

Keywords: secondhand smoking, pain, postoperative complications
oral steroids before pulmonary vein isolation to improve outcomes

Conditions: Atrial Fibrillation

Summary: the primary purpose of this study is to assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation.

the purpose of this study is: 1. to assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation. 2. to measure the inflammatory cytokine (tnf-α, il-1, il-6, il-8) response to radiofrequency ablation for atrial fibrillation with or without prior prednisone treatment.

Eligibility criteria:
inclusion criteria: 1. able to provide written informed consent; 2. scheduled for radiofrequency ablation procedure for treatment of atrial fibrillation exclusion criteria: 1. history of heart failure (right or left or biventricular) or cardiomyopathy. 2. immunosuppressive disorders and systemic fungal infection 3. concurrent use of corticosteroids in one week prior recruitment. 4. allergy or prednisone or its components. 5. other medical conditions were use of corticosteroids is not recommended or contraindicated. 6. patients with chronic and permanent atrial fibrillation. 7. patients with established diagnosis of rheumatological and immunological disorders.

Keywords: atrial fibrillation; ablation
assessment of the prevalence of sarcopenia by ct scan in patients diagnosed with head & neck cancer

Conditions: Sarcopenia; Cancer of Head and Neck; CT Scan

Summary: sarcopenia is defined by the reduction in skeletal muscle mass and physical performance. it results in a decrease in muscle strength, overall physical activity, walking and the development of balance disorders and falls. it is one of the natural consequences of aging and contributes to frailty and the appearance of geriatric syndrome (s) (chandapasirt et al, 2015; cruz-jentoft et al, 2010). its prevalence in patients with head \& neck cancer is 39% (hua et al, 2020) and is associated with an increase in postoperative complications (achim et al, 2017; bril et al, 2019), with greater toxicity of chemotherapy. (wendrich et al, 2017) and reduced overall survival (hua et al, 2020). it is measured by ct scan (assessment of muscle volume with respect to l3 using image j software) (teigen et al, 2018) and by clinical tests (performance tests) (swartz et al, 2016, cruz-jentoft et al, 2010). several studies have shown a possible assessment of sarcopenia by measuring skeletal muscle mass with regard to c3 (ufuk et al, 2019; swartz et al, 2016). this trial aims to evaluate the prevalence of sarcopenia in head and neck cancer evaluated by ct at c3.


Eligibility criteria:
inclusion criteria: * patient over 18 years old, * affiliated to the social security scheme, * suffering from locally advanced head \& neck cancer (stages i to ivb) at diagnosis, * not operable, * justifying treatment by radiotherapy, whether or not associated with chemotherapy or targeted therapy (eg: monoclonal antibodies, immunotherapy) whatever the proposed modalities. exclusion criteria: * patient treated by non-conservative surgery and cervical lymph node dissection making it impossible to assess muscle mass with regard to c3, * metastatic disease, * minor patient, * adult patient under guardianship, * pregnancy or breastfeeding in progress.
helicobacter pylori treatment in immune thrombocytopenic purpura (itp) patients

Conditions: Immune Thrombocytopenic Purpura; Helicobacter Pylori Infection

Summary: the purpose of this study is to determine whether eradication of helicobacter pylori infection is effective in the improvement of platelet counts in children and adolescents with chronic itp.

helicobacter pylori infection has been associated with immune thrombocytopenic purpura (itp), and there is scientific evidence for the investigation and treatment of this bacterium for adult patients with itp. however, in children this causal association is not clear, with few published studies.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic immune thrombocytopenic purpura * children and adolescents up to 20 years exclusion criteria: * known hypersensitivity to any of the drugs * recent treatment for h. pylori eradication

Keywords: immune thrombocytopenic purpura chronic immune thrombocytopenic purpura secondary immune thrombocytopenic purpura helicobacter pylori infection helicobacter pylori gastritis children adolescents
maternal physical activity and pregnancy outcome

Conditions: Pregnancy Complications

Summary: the aim of this study is to investigate the impact of maternal physical activity during pregnancy on pregnancy outcome. primary, fetal growth during pregnancy abd birth weight will be examined.

during this study, the information on maternal physical activity will be collected and the impact on delivery and pregnancy complications as well as on neonatal complications will be evaluated. from the first visit at maternal care center, the information on socioeconomical and maternal characteristics will be collected. during pregnancy, fetal growth will be estimated by ultrasound. physical activity will be measured using free app for measuring steps that mothers make during pregnancy. using logistic regression, the impact of physical activity on pregnancy outcomes will be evaluated.

Eligibility criteria:
inclusion criteria: healthy women with singleton pregnancies - exclusion criteria: * twins pregnancies. mothers with preexisting conditions. malformations.

Keywords: pregnancy, physical activity, fetal growth
zip incision approximation vs. suture for c-section

Conditions: C.Surgical Procedure; Dehiscence, Cesarean Section

Summary: the study will evaluate the zipline medical surgical skin closure device (zip)versus sutures when utilized for skin layer closure during wound closure of cesarean section procedure.

cesarean-section birth is a very invasive surgical procedure. while the desired outcome focuses primarily on the successful delivery of a healthy baby and maintenance of the mother's health, the surgery involves a complex surgical closure process, starting with the uterus, and progressing through several layers of traditionally suture closure in several tissue planes. a successful closure results in no surgical site complications, with good patient comfort and a minimal scar being a desired outcome. conventional skin closure methods such as sutures are effective but have drawbacks. it has been suggested that the ideal method of wound / incision closure should be: * fast * non-traumatic * minimally or non-invasive * associated with a low incidence of adverse events such as dehiscence and infection * yielding acceptable cosmetic results zipline medical, inc. is a campbell, california-based company that has developed a novel, non-invasive skin closure device called zip surgical skin closure to replace sutures, staples and glue for closure of the skin layer for surgical incisions or laceration repair. in the usa, the device has been classified by the fda as a class i, 510(k) exempt device and began commercial use in the usa in april 2013. the zipline device has been clinically demonstrated benefits include (references included later in this document): * closure speed faster/superior to (and less variable compared to) sutures * suture-like cosmetic outcome * reduction in post-surgical care costs * fewer closure-related wound issues * greater patient satisfaction

Eligibility criteria:
inclusion criteria: 1. patients 18 years of age and older 2. primary c-section 3. patients willing and able to complete study protocol exclusion criteria: 1. known bleeding disorder not caused by medication 2. known personal or family history of keloid formation or scar hypertrophy 3. known allergy or hypersensitivity to non-latex skin adhesives 4. atrophic skin deemed clinically prone to blistering 5. any skin disorder affecting wound healing 6. any other condition that in the opinion of the investigator would make a particular subject unsuitable for this study 7. emergent c-section 8. non-primary c-section
comparison of myocardial infarction patients who were prescribed a novel antiplatelet agent or clopidogrel

Conditions: Myocardial Infarction

Summary: myocardial infarction is defined according to icd-10 using the data base of south korea national health insurance corporation, where personal identification information has already been removed, and detailed results are derived for each drug category.

the purpose of this study is to compare the prognosis of patients with clopidogrel after early discontinuation of ticagrelor/prasugrel with patients who maintained aspirin and ticagrelor/prasugrel as standard therapy in patients with acute myocardial infarction who underwent percutaneous coronary intervention.

Eligibility criteria:
inclusion criteria: * patients who have a diagnosis code for acute myocardial infarction indicated in the national health insurance data and data for drugs that have used ticagrelor/prasugrel for 30-90 days when hospitalized for the relevant disease. * patients who switched to clopidogrel after 30-90 days. * patients with a diagnosis code for venus myocardial infarction and a prescription code for percutaneous cardiovascular intervention in the national health insurance data. * adults 18 years of age or older exclusion criteria: * a person who has data for requesting blood transfusion during the period of hospitalization in the national health insurance data * those who have data for oral anticoagulants (warfarin, coumadin, apixaban, edoxaban, dabigatran, rivaroxaban) in the national health insurance data * those who have a diagnosis code for malignant tumor in the national health insurance data * those who have end-stage renal failure code in the national health insurance data or those who have data for hemo/peritoneal dialysis * a person who has a request for blood transfusion during the period of using ticagrelor/prasugrel

Keywords: clopidogrel novel antiplatelet agent
antiarrhythmic and symptomatic effect of isis crp rx targeting crp in paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: the purpose of this study is to evaluate whether treatment with isis crp rx can reduce af (atrial fibrillation) burden (percentage of time spent in af) in subjects with paroxysmal af


Eligibility criteria:
inclusion criteria: * male of female; age over 18 years * dual chamber permanent pacemaker implanted * confirmed diagnosis of paroxysmal atrial fibrillation with an af burden of 1 to 50%, as derived from pacemaker diagnostic algorithms * able to have pacemaker antiarrhythmic algorithms turned off for the duration of the study * able to discontinue all class i and iii antiarrhythmic medication for the duration of the study * therapeutically anticoagulated with warfarin or dabigatran, and anticipated to be for duration of the study * high sensitivity c-reactive protein (hscrp) between 2 and 10 mg/l (inclusive) exclusion criteria: * clinically significant abnormalities in medical history, physical examination, or screening laboratory results that would render a subject unsuitable for inclusion * nyha class iii/iv heart failure * impaired left ventricular function of less than 45% determined by echocardiography within 3 months of screening * moderate or greater mitral regurgitation assessed by echocardiography within 3 months of screening * permanent af * continuous amiodarone therapy within 90 days prior to study day 1 * treatment with another study drug, biological agent, or device within one-month of screening, or five half-lives of study agent, whichever is longer * use of systemic corticosteroids or other anti-inflammatory medications including non-steroidal anti-inflammatory drugs (nsaids) * use of statins, ace inhibitors or at-receptor antagonists unless on a stable regimen for at least 3 months prior to dosing and will remain on a stable regimen for the duration of the study * uncontrolled hypertension (bp \>160/100) * current or expected use of any anticoagulant apart from warfarin or dabigatran

Keywords: atrial fibrillation paroxysmal atrial fibrillation af
cpr quality and use of feedback for ohca

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: the purpose of this study is to investigate the quality of cardio-pulmonary resuscitation(cpr) delivered by ems professionals and whether this quality can be improved by implementing real-time feedback during the event and an oral post-event debriefing procedure based on the actual event performance data.

the aim of this study is to investigate whether cpr quality can be improved by implementing real-time feedback and immediate oral structured post-event debriefing in out-of-hospital cardiac arrest (ohca). the objectives of this study is to assess the current quality of cpr delivered by emergency medical services (ems) during ohca events in the capital region of denmark. furthermore, to investigate if cpr quality can be improved by applying real-time feedback during ohca resuscitation attempts and to investigate if structured oral post-event debriefing delivered immediately after a resuscitation attempt and based on data from the defibrillator can further improve cpr quality the hypothesis of this study is that adding real-time and post event feedback can improve the compression rate, compression depth, overall cpr hands-on time (cpr fraction), and recoil with at least 15% in total for both interventions. using a prospective study design data is retrieved from the standard defibrillator (zoll x series) through zoll rescuenet® case review (software for post-event review, analysis, and debriefing) from zoll medical corporation, massachusetts, united states of america. the study consists of three consecutive phases. phase one with no feedback / debriefing available for ems. phase two with real-time feedback during the event and phase three which adds post-event debriefing to real-time feedback. we expect to be able to include at least 500 cases in each phase.

Eligibility criteria:
inclusion criteria: ohca exclusion criteria: no use of ems defibrillator attached to patient during resuscitation attempt patients \< 18 years of age ohca without involvement of the physician manned vehicle patients who are subject to mechanical cpr from the time of device attachment traumatic ohca

Keywords: ohca feedback cpr quality
increasing covid-19 testing in chicago's african american testing desserts

Conditions: COVID-19 Pandemic

Summary: this study uses a population-based approach to increase uptake of covid-19 testing within a highly segregated and underserved african american community in chicago.

the epidemic of novel coronavirus disease 2019 (covid-19) has caused an unprecedented public health crisis in the united states. african americans (aa) have been disproportionately impacted, as systemic inequities have contributed to increased exposure and vulnerability to covid-19. evidence suggests that aas are delaying testing and care for covid-19, which increases risk of transmission and poor outcomes. in chicago, segregated aa neighborhoods have experienced some of the highest covid-19 mortality rates in the city, yet large portions of these neighborhoods remain testing deserts. providing trusted, accessible, community-based testing in underserved aa communities is critical to ensuring that aas receive an early diagnosis, thereby reducing the risk of further transmission and improving clinical outcomes. this study leverages the alive church network (acn), a long-standing, community-driven coalition of african american pastors and public health researchers that was developed as a sustainable infrastructure to address health inequities in chronic disease in segregated aa neighborhoods in chicago. the acn was designed to address lack of access to health care, cultural insensitivity, and lack of trust, which are the root cause of disparities in chronic disease as well as infectious disease, including covid-19. this project utilizes the acn infrastructure to create a network of church-based testing sites in a segregated and underserved aa neighborhood in chicago that will provide covid-19 testing and education as well as linkage to healthcare and social resources. pastors who serve predominantly aa congregations on the south side of chicago will form a coalition to promote community-wide covid-19 testing in local churches and church-based events where residents are congregating, such as sunday church services, food pantries, and other gatherings. residents of all ages will receive covid-19 education and free severe acute respiratory syndrome coronavirus 2 (sars-cov-2) polymerase chain reaction (pcr) testing with rapid turn-around of results from an on-site clinical team, as well as connection to local resources to address social needs, including food, housing, and medical care. at-home covid-19 tests will also be provided to residents for their personal use and to distribute to others in their social network. the primary aim of the study is to evaluate the impact of the acn covid-19 testing intervention on uptake of testing among residents of target high poverty aa neighborhoods in chicago.

Eligibility criteria:
inclusion criteria: • all individuals who request a covid-19 test, including pregnant women and children of all ages exclusion criteria: • individuals who have tested positive for covid-19 in the prior 3 months
vitamin d status in relation to insulin sensitivity among saudi women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the study tests the hypothesis that correction of vitamin d deficiency among women with pcos will improve insulin sensitivity and resistance and inflammatory response to pcos.

polycystic ovary syndrome (pcos) is a common complex and heterogenous endocrine disorder. it affects ≤10% of women of reproductive age, with approximately 16%-80% of the affected women being obese. polycystic ovary syndrome frequently is associated with insulin resistance (ir) accompanied by compensatory hyperinsulinemia, and ir is aggravated by the interaction between obesity and the syndrome. moreover, the contribution of body mass and/or body fat distribution to ir of pcos remains controversial. in addition, women with pcos with ir are at an increased risk of developing diabetes, hypertension, dyslipidemia and atherosclerosis. preliminary data on the local women with pcos showed high prevalence of vitamin d deficiency (serum 25(oh)d \< 50 nmol/l). recent studies showed that vitamin d deficiency is linked to ir, type 2 diabetes mellitus, obesity, inflammation and cardio vascular disease. several studies have demonstrated that serum 25(oh)d levels were negatively correlated with body mass index (bmi), body fat, and ir. these conditions are common among women with pcos. accordingly, it is anticipated that vitamin d deficiency and/or insufficiency may contribute to the endocrine and metabolic disarrangements among women with pcos. such adverse effects may further contribute to the risk of further long term complications among women with pcos.

Eligibility criteria:
inclusion criteria: pcos diagnosis to include three of the rotterdam criteria exclusion criteria: pregnancy lactation taking vitamin d or calcium supplement in excess of a regular multivitamins diabetes mellitus uncontrolled hypertension liver disease renal disease secondary causes of hyperandrogenism metabolic bone disease thyroid dysfunction taking oral contraceptives taking hypoglycemic agents (metformin or thiazolidinediones) medication to affect plasma sex steroids for \>/3 months before the study smokers

Keywords: pcos vitamin d insulin resistance glycemic control
dry needling of scalene muscle trigger points in mechanical neck pain

Conditions: Neck Pain

Summary: there is preliminary evidence suggesting that referred pain from active trigger points can play a relevant role in individuals with mechanical neck pain. some studies have investigated the effectiveness of dry needling over the upper trapezius muscle in this population. however, other muscles, such as the scalene muscles, can be also relevant for neck pain symptoms. no study has investigated the effects of the application of dry needling over active trigger points in the scalenes muscles in a sample of patients with mechanical neck pain.


Eligibility criteria:
inclusion criteria: generalized neck-shoulder pain with symptoms provoked by neck postures, neck movement, or palpation of the cervical musculature exclusion criteria: * whiplash injury; * previous cervical or thoracic surgery; * cervical radiculopathy or myelopathy; * diagnosis of fibromyalgia syndrome; * having undergone physical therapy in the previous 6 months; * less than 18 or greater than 45 years of age * fear to needles * any respiratory disease, e.g., chronic brochitis
vitamin d treatment in patients with chronic hepatitis c

Conditions: Chronic Hepatitis C

Summary: we hypothesize that patients with ch.hcv have a low level of vitamin d, and that by raising their vitamin d levels by adding it to their standard treament of pegylated interferon and ribavirin, there will be an increase in their sustained virological response.


Eligibility criteria:
inclusion criteria: * chronic hepatitis c genotype 1 exclusion criteria: * vitamin d intoxication renal failure liver failure malignancy

Keywords: patients with chronic hepatitis c