Kornimate/medical-research-clean huggingface dataset:
prospective cohort study on the determinants of venous thromboembolic recurrence

Conditions: Thromboembolic Venous Disease

Summary: the main objective of the breizh-cohorte study is to determine the incidence of recurrent short, medium and long-term thromboembolic venous disease as well as risk factors for recurrence in two specific populations: patients under 50 years of age, men and women (5 year recurrence), as well as cancer patients (all ages) (1 year recurrence).

deep vein thrombosis (dvt) and pulmonary embolism (pe) are two clinical manifestations of the same entity, thromboembolic venous disease. this disease is frequent: the annual incidence of thromboembolic venous disease estimated between 1 and 2 cases per 1000 inhabitants per year in france, comparable to that observed in north america. this disease is potentially serious: the mortality from pe, the most severe manifestation of thromboembolic venous disease (one third of pe for two thirds of dvt) is 10% at 3 months, twice as high as that of myocardial infarction. however, the risk of pe in isolated dvt is major (more than 50% of cases). thus, whether it is a pe or a dvt, anticoagulant treatment, a cornerstone of therapeutic management, must therefore be initiated urgently, without waiting for the results of diagnostic confirmatory examinations. the major complications occurring after a thromboembolic venous disease are venous thromboembolic recurrence (vte) and the long-term consequences: post-thrombotic syndrome and the development of post-embolic pulmonary hypertension. vte recurrence has significant mortality, particularly in the form of pe (15%, compared to 2% in the form of dvt). as for long-term complications of vte, about 20-30% of patients with dvt develop post-thrombotic syndrome at 5 years (27), while 0.15% to 5% of patients with pe develop post-embolic pulmonary hypertension at 1 year. while major progress has been made over the past 20 years in terms of diagnosis, primary and secondary prevention, identification of risk factors for vte and prognostic factors, however, two particular subgroups deserve to be specifically investigated: young subjects, whether women (hormonal exposure) or men (often idiopathic thromboembolic venous disease), and cancer patients. in the latter, the progress made on anti-cancer treatments is helping to modify the data on the risk of vte as well as the duration of treatment of vte in these patients. thus, this prospective cohort covers two subgroups of patients with thromboembolic venous disease: young subjects (≤50 years) or those who have cancer.

Eligibility criteria:
inclusion criteria: * subject aged 18 or over, or a minor with the consent of the parents and the minor, presenting with a thromboembolic venous disease * 50 and under or any age if active cancer * affiliated to social security * accepting to participate in the study. exclusion criteria: * foreign nationality. * inability to communicate (comprehension disorder). * refusal to participate.
adaptive goal-directed adherence tracking and enhancement

Conditions: Alcohol Abuse

Summary: talaria, inc., has designed an adherence tracking and enhancement system, called agate, which uses the text messaging and internet capabilities of modern cellular phones to address the problem of medication adherence in clinical care and clinical trial contexts. this trial will evaluate whether agate improves medication adherence in the context of a pharmacotherapy trial of naltrexone to treat problem drinking. all participants will be treatment-seeking problem drinkers who will receive naltrexone and medication monitoring over 8 weeks.

the purpose of the naltrexone trial is to evaluate whether agate effectively measures and enhances medication adherence in the context of naltrexone treatment for problem drinking. participants will be heavy/problem drinkers, recruited from the greater albuquerque area, who are interested in either reducing or stopping their drinking and deemed to be candidates for naltrexone pharmacotherapy by the study psychiatrist, dr. arenella. all participants will be prescribed naltrexone, 50 mg, once daily, for eight weeks, and receive smartphones. participants will be randomly assigned to receive either agate or sased, a web-based alcohol and side-effects diary via smartphone. the primary outcome will be percent of scheduled doses that were taken during the eight week trial, as measured by the medication event monitoring system (mems, aardex group, union city, ca), pill counts, and using the timeline follow-back (tlfb) method.

Eligibility criteria:
inclusion criteria: * problem or heavy drinkers * age 21-55 years old * located in the greater albuquerque nm area * interested in either reducing or stopping their drinking * candidates for naltrexone pharmacotherapy exclusion criteria: * participation in other naltrexone study * unable to operate a smartphone * significant psychiatric or physical illness * current drug dependence * current regular opioid use * any recent nonmedical opioid use * any lifetime opioid dependence

Keywords: naltrexone problem drinking medication adherence adherence smartphone
a study of people with type 2 diabetes who have diseases that affect the heart and blood vessels. the study will also look at the treatment of a group of these people in hospitals in portugal

Conditions: Diabetes Mellitus, Type 2

Summary: this study aims to estimate the number of patients with cardiovascular disease and risk factors in patients who had been diagnosed with type 2 diabetes mellitus. simultaneously, this study also intends to obtain more information about the management of type 2 diabetes mellitus patients with established cardiovascular disease. this study is non-interventional, which means that will not require participant's further related visits or procedures. the study will collect the participant's clinical data from the current visit and, when applicable, within the last 3 years.


Eligibility criteria:
inclusion criteria: main study population (data collection - prevalence): * signed informed consent form (icf) obtained before any study-related activities (study-related activities are any procedures related to recording of data according to protocol) * male or female patient, age greater or equal to 18 years at the time of signing icf * patients diagnosed with type 2 diabetes subgroup (data collection - patient management): * patients followed at the hospital setting by the endocrinologist or internal medicine specialist (ambulatory diabetes management) and with available medical records, retrospectively within the last three years * patients with type 2 diabetes mellitus and established cardiovascular disease diagnosed at least three years ago exclusion criteria: * previous participation in this study. participation is defined as signed icf * female patient who is pregnant or breast-feeding * patients with type 1 diabetes * participation in a clinical trial within the last 3 years
covid-19: herd immunity study in the czech republic

Conditions: COVID; SARS-CoV 2

Summary: the aim of the sars-cov-2-cz-preval study is to quantify the prevalence of individuals with a history of sars-cov-2 coronavirus infection in the czech population, except for those diagnosed with covid-19 by methods based on direct detection of sars-cov- 2, including individuals with a subclinical course of the disease.

covid-19 is caused by a new type of coronavirus called sars-cov-2. it is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. however, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in covid-19. one of such key pieces of information is the prevalence of asymptomatic individuals with sars-cov-2 infection, which has a significant effect on the dynamics of the spread of covid-19 in the czech republic and within individual regions and localities. the sars-cov-2-cz-preval study is aiming at quantification of the prevalence of individuals with a history of sars-cov-2 coronavirus infection in the czech population, except for those diagnosed with covid-19 by methods based on direct detection of sars-cov- 2, including individuals with a subclinical course of the disease.

Eligibility criteria:
inclusion criteria: * signed informed consent * residing in the czech republic * demographic criteria: (i) persons aged 8-17 (specific children's cohort), (ii) persons aged 18-89 * clinical criteria: (i) without acute health problems (ii) without a confirmed diagnosis of covid-19 * geographic criteria: according to a particular cohort definition

Keywords: sars-cov-2 prevalence asymptomatic infection spread dynamics
treating heel pain in adults: a randomized clinical trial of hard versus soft orthotics

Conditions: Heel Pain Syndrome

Summary: objectives: this study compared the effectiveness of soft versus hard orthotics in treating heel pain and plantar fasciitis in adults. it also compared the level of function after orthotic use, cost and number of visits for orthotics and explored if age was a factor in orthotic effectiveness.

design: this randomized clinical trial included 44 adults (18+) with heel pain and plantar fasciitis. participants received hard or soft customized orthotics and rated their pain intensity, pain interference and function, pre and post orthotic use. scores were analyzed with repeated measures anova. analysis of age used repeated measures anova. costs were compared using t-test and number of visits was compared using wilcoxon rank sum.

Eligibility criteria:
inclusion criteria: * sample of convenience from the hospital and private clinic. the participants had heel pain associated with plantar fasciitis. participants could describe and report changes in their pain exclusion criteria: * those excluded were non-ambulatory (unable to walk greater than 25 meters) orchid spasticity due to a neurological disorder. others excluded were non-communicative, had cognitive impairment or were unable to complete a questionnaire.

Keywords: foot heel pain plantar fasciitis orthotic devices
improvement of the etiological diagnosis of the pericarditis

Conditions: Infective Pericarditis

Summary: pericardial syndrome includes pericardites acute pericardial effusion and cardiac tamponade, recurrent pericarditis squeezing chronic pericarditis. the etiologies are very numerous and can be classified as infectious, neoplastic, metabolic or systemic, toxic causes. diagnosis is difficult, and 80% of etiologies remain classified idiopathic. in their laboratory to improve the diagnosis of this syndrome investigators have developed a strategy of systematic prescription of biological tests by kit. this prescription by 'kit' strategy proved its interest by comparison with an intuitive requirement of biological. in this study investigators want to improve the diagnostic causative of pericarditis by implementing a new diagnostic strategy. this new strategy includes (i) samples additional less invasive for the patient, the swab pharyngeal and nasal, (ii) the addition of at the outset of more effective diagnostic techniques: specific polymerase chain reaction (pcr)


Eligibility criteria:
inclusion criteria: * patient prescribed with a pericarditis kit for etiological diagnosis of a pericardial syndrome. * adult patient (= or \> 18 years old) * patient who freely signed the informed consent form. * patient affiliated to a health insurance regime exclusion criteria: * minor patient ( age \<18 years) * pregnant, parturient or breastfeeding woman * adult patient incapable or unable to consent * patient deprived of liberty under judgment * person living in a health or social specialised structure * person in vital emergency situation
fluid restriction in respiratory distress of the newborn

Conditions: Respiratory Distress Syndrome, Newborn

Summary: the object of this study is to determine the best way to care for infants with respiratory distress. the investigators are testing a method of feeding fluids to infants with respiratory distress in amounts similar to what healthy breastfed babies eat when they are feeding on demand, and comparing this method to the current standard of care for feeding fluids to infants with respiratory distress. these methods of feeding fluids to the study infants will continue until the infants are able to feed normally by mouth. the study will include about 400 infants across five sites in the united states, chile and argentina.

infants with respiratory distress syndrome will be enrolled within the first twelve hours of life, and randomly assigned to one of two groups: the first group will receive the interventional fluid management method, and the second (the control group) will receive the current standard of care for fluid management. to standardize respiratory care across all five study sites, a computer-based algorithm for respiratory support management based on objective markers of respiratory distress will guide clinician management decisions. however, each infant's medical team will make all final decisions on respiratory treatment and iv fluid management. any study infant who experiences dehydration and/or low blood sugar during the course of the study will be removed from the study and be treated for the condition.

Eligibility criteria:
inclusion criteria: * neonates born between 34-0/7 and 41-6/7 weeks gestational age (ga) at birth with primary pulmonary disease of the newborn including transient tachypnea of the newborn (ttn), respiratory distress syndrome (rds), air leak syndrome, pneumonia, or meconium aspiration syndrome in the first 12 hours of life will be eligible for inclusion in this study. * those neonates who are intubated for administration of exogenous surfactant but who are immediately extubated to non-invasive respiratory support after surfactant administration will remain eligible for study inclusion. exclusion criteria: * neonates with a genetic abnormality or congenital anatomic anomaly subsequent study exclusion resulting in removal from study: * neonates who subsequently undergo endotracheal intubation and mechanical ventilation for refractory respiratory distress * neonates with hypoglycemia or clinical evidence of dehydration or volume depletion requiring fluid bolus * infants that are transported out of the participating site prior to study endpoint.

Keywords: respiratory distress syndrome, newborn fluid restriction
titrated versus high and low dose nebulized morphine to reduce pain in emergency settings

Conditions: Post-Traumatic Headache; Acute Pain

Summary: the investigators test a different technique using morphine to improve pain relief in patient visiting the emergency department with acute trauma pain, for this we are comparing three different methods of morphine administration: * intravenous titrated morphine * low dose nebulized morphine and * high dose nebulized morphine

trauma patients are frequent in emergency department settings, and often require urgent care. taking care of this patients consists on taking care of their pain and then the specific treatment of their traumatic lesions. actually, the most used medicine and most efficient one in treating pain is morphine, it's mechanism of action is by acting on receptors located on neuronal cell membranes and inhibit neurotransmitter release. the most applied administration root of morphine is by intravenous (iv) titration or iv continuous perfusion, but until now, there is no clear recommendation concerning the superiority of this root over other administration techniques such as nebulization. in this study we aimed to investigate the efficiency, the feasibility and the tolerance of three morphine administration roots in patients with acute traumatic pain and to clarify the most adequate one to apply in emergency department settings.

Eligibility criteria:
inclusion criteria: * patients older than 8 years and less than 50 years * patients who consult emergency department for sever pain after an immediately trauma exclusion criteria: * glasgow coma scale \<14 * inability to cooperate * hypotension with systolic blood pressure\< 90mmhg * bradypnea\<12cpm * sao2\<90% * polytrauma * nasal trauma * rhinitis * nasal obstruction * allergy to opioids

Keywords: post traumatic pain titrated morphine nebulised morphine
compliance and safety study in children with upper and lower respiratory tract infections

Conditions: Respiratory Tract Infections

Summary: the objective of this study was to obtain data on the safety, tolerability and compliance with zithromax in children with bacterial infections of the upper and lower respiratory tract.

patients were recruited from the outpatient departments of the participating sites/hospitals/clinics.

Eligibility criteria:
inclusion criteria: * patients with respiratory tract infections that received azithromycin according to the approved spc as this was a non-interventional study. exclusion criteria: * according to the approved summary of product characteristics (spc) for azithromycin as this was a non interventional study.

Keywords: compliance and safety study in children with upper and lower respiratory tract infections
evaluation of three continuation therapies after ect concerning efficacy and cognition in severly depressed patients

Conditions: Depression; Major Depression

Summary: the purpose of this study is to evaluate three different continuation treatments after acute ect concerning efficacy and impact on cognition in severly depressed patients.

background while electroconvulsive therapy (ect) in major depression is effective, high relapse rates and cognitive effects limit its long-term use. continuation treatment after ect with combinations of c-ect or psychotherapy and medication may decrease relapse rates and cognitive side effects while changing cognitive psychological variables like dysfunctional attitudes in the long-term. central research questions * evaluation of the efficacy of three continuation treatments aimed at preventing relapses after acute ect * examination of the cognitive side effects and the changes of cognitive psychological variables during acute and continuation treatment methods in a prospective, randomized, controlled, long-term study we assign 60 depressed ect responder either to antidepressant treatment alone, or c-ect plus medication, or cognitive behavioral group therapy plus medication. depressive symptoms and cognition were assessed before, during, immediately after acute ect and two, four, six, and 12 months during continuation therapy. hypotheses it is hypothesized that the use of combination continuation therapies after effective ect leads to lower hamd scores and lower relapse rates than the standard treatment with antidepressants alone after 6 months. in addition, we assume that the cbt group will establish more functional macro-patterns than the somatic treatments in the long term and will have the lowest hamd scores and relapse rates after 1 year. with regard to the cognitive side effects, the autobiographical memory is expected to be the only specific part of memory being affected negatively by ect in the short and long term.

Eligibility criteria:
inclusion criteria: * major depressive episode (unipolar) * response to acute ect (at least 50% reduction in hamd) * capacity to consent * sufficient comprehension of the german language exclusion criteria: * schizophrenia, schizoaffective disorder, or other psychosis * amnestic disorder, dementia, or delirium * pregnancy * epilepsy * current alcohol or substance abuse or dependence * cns disease or brain injury not associated with psychotropic drug exposure * ect in the past 3 months * acute suicidality * judiciary hospitalization

Keywords: therapy resistant depression, severe depression
study on the postoperative complications and changes in posterior cervical muscle volume after cervical single open-door expansive laminoplasty with preservation of muscular ligament complex

Conditions: Cervical Myelopathy

Summary: in 2006, our hospital improved and began to use cervical expansive open-door laminoplasty preserving the unilateral ligament with muscle complex.the effect of recent follow-up, postoperative complications and their effects on posterior cervical muscle volume were also studied.however, there are few reports about medium and long-term follow-up.

expansive laminoplasty of posterior cervical canal has been widely used for the treatment of cervical spondylotic myelopathy with cervical spinal stenosis and ossification of the posterior longitudinal ligament since hirabayashi et al. described it in the 1970s. traditional single-door surgery requires extensive dissection of both paravertebral muscles and ligaments, and resect part of the spinous process. postoperative complications (axial neck pain, stiffness, cervical kyphosis, reduced range of motion, etc.) are also related to that in degree. in order to reduce the damage to the posterior cervical structure and reduce the associated complications, in the 1990s, yoshihiko oshima et al. introduced the expansive laminoplasty of the spinal canal with one side of the posterior ligamentwith muscle complex attached to the spinous process. in 2006, our hospital improved and began to use cervical expansive open-door laminoplasty preserving the unilateral ligament with muscle complex.the effect of recent follow-up, postoperative complications and their effects on posterior cervical muscle volume were also studied.however, there are few reports about medium and long-term follow-up.

Eligibility criteria:
inclusion criteria: * from 2006 to 2018, the patients admitted to the orthopedic department of our hospital for posterior cervical open-door expansive spinal canal laminoplasty with one side muscle-ligament complex reserved.complete preoperative and postoperative diagnosis and treatment data of our hospital were available, and the follow-up time was ≥2 years. exclusion criteria: * patients with incomplete preoperative and postoperative diagnosis and treatment data or less than 2 years of follow-up

Keywords: single open-door expansive laminoplasty preserving the unilateral ligament with muscle complex postoperative complications effects on posterior cervical muscle volume